title: Differential mitosis and degeneration patterns in relation to the alterations in the shape of the embryonic ectoderm of early post-implantation mouse embryos.
abstract: The shape of the embryonic ectoderm of early post-implantation mouse embryos changes greatly in the period of 6.2-7.3 days post coitum. The subcellular morphology of the embryonic ectoderm remains unchanged, except in the primitive-streak region. Cell kinetics differ between ectodermal regions. These differences may be related to the changes in the shape of the ectoderm. The increase in cell number in the lateral ectoderm (the prospective surface ectoderm) exceeds that in the frontal ectoderm (the future neurectoderm). This is not due to differences in the duration of the cell cycle. It can be explained, however, by the occurence of different relative numbers of dividing and non-dividing cells. These numbers vary between the two regions. The percentage of non-dividing cells in the frontal ectoderm may reach 45, whereas in the lateral ectoderm this percentage is not higher than 15. Autoradiography in tritiated thymidine-treated embryos combined with the mitotic indices gave us all of the parameters necessary to present a model capable of clarifying the growth of the ectoderm during gastrulation, as well as the changes in the shape of the ectoderm.
mesh_terms: D000818:Animals; D001345:Autoradiography; D002452:Cell Count; D002453:Cell Cycle; D002454:Cell Differentiation; D002470:Cell Survival; D004475:Ectoderm / Q000648:ultrastructure*; D005865:Gestational Age; D051379:Mice; D008938:Mitosis