Calcitonin secretion in congenital nongoitrous cretinism.
Plasma calcitonin (CT) was measured in the basal state and/or during provocative tests of hormone secretion in 11 children with congenital non-goitrous cretinism (CNC), in 1 girl with a lingual thyroid, and in 11 normal children. Basal and stimulated CT concentrations were significantly lower in the patients with CNC than in the normal subjects. Mean basal CT (+/- SE) was 41 +/- 4 pg/ml in the normal children, 24 +/- 3 pg/ml in the children with CNC, and 20 +/- 2 pg/ml in the patient with the lingual thyroid. The mean incremental CT responses to calcium infusion were 7.0 +/- 2 pg/ml in the children with CNC, 6.0 pg/ml in the patient with the lingual thyroid, and 146 +/- 47 pg/ml in the normal children. The children with CNC also demonstrated a significant delay in the return of the total serum calcium to basal level after the calcium infusion. The mean incremental CT response after infusion of pentagastrin was 7.6 +/- 2 pg/ml in the children with CNC, 10.0 pg/ml in the child with the lingual thyroid, and 34.4 +/- 11 pg/ml in the normal children. These data indicate that CT deficiency is present in children with CNC and suggest that the deficiency is a consequence of the defective embryologic development of the thyroid gland.
D000293:Adolescent; D002116:Calcitonin / Q000097:blood / Q000378:metabolism*; D002118:Calcium / Q000097:blood / Q000494:pharmacology; D002648:Child; D002675:Child, Preschool; D003409:Congenital Hypothyroidism / Q000151:congenital / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D010418:Pentagastrin / Q000494:pharmacology; D013961:Thyroid Gland / Q000166:cytology / Q000378:metabolism*
D002116:Calcitonin; D010418:Pentagastrin; D002118:Calcium