title: Differential effects of benztropine and desipramine on the high affinity uptake of paratyramine in slices of the caudate nucleus and hypothalamus.
abstract: The effect of benzotropine and desipramine on the uptake of dopamine and p-tyramine was studied in slices of caudate and hypothalamus. In the hypothalamus, of the various combinations of drugs and amines, desipramine inhibited p-tyramine uptake most effectively. In the caudate, benzotropine inhibited dopamine uptake most effectively. It is suggested that in the caudate, p-tyramine may possess its own unique transport system distinct from that utilized by dopamine which is inhibited by benzotropine.
mesh_terms: D000818:Animals; D001590:Benztropine / Q000494:pharmacology*; D001692:Biological Transport; D002421:Caudate Nucleus / Q000187:drug effects* / Q000378:metabolism; D003891:Desipramine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D014326:Tropanes / Q000494:pharmacology*; D014439:Tyramine / Q000378:metabolism*
chemical_list: D014326:Tropanes; D001590:Benztropine; D003891:Desipramine; D004298:Dopamine; D014439:Tyramine