title: Treatment of premature labor with the calcium antagonist nifedipine.
abstract: The effect of the calcium antagonist nifedipine on premature labor was investigated in ten carefully selected patients. The main aim of treatment was to inhibit uterine activity and delivery for 3 days during which time fetal lung maturation was accelerated by glucocorticoid treatment. In all 10 patients, uterine activity was abolished during the 3 days of treatment and delivery was also postponed. No serious maternal side effects were observed. All children were delivered in good condition. All survived and were alive and well at 1 year.
mesh_terms: D000328:Adult; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008168:Lung; D009543:Nifedipine / Q000009:adverse effects / Q000627:therapeutic use*; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011725:Pyridines / Q000627:therapeutic use*; D012127:Respiratory Distress Syndrome, Newborn / Q000517:prevention & control; D013997:Time Factors
chemical_list: D005938:Glucocorticoids; D011725:Pyridines; D009543:Nifedipine