Effect of aspirin on the complement system in vitro.
Aspirin (acetylsalicylic acid), ASA and sodium salicylate (NaSA) activate the complement system in vitro. The activation involves the components of the classical pathway. It is, however, antibody independent. Evidence for activation are (1) consumption of C and C component activities; (2) activation of C1 evidenced by release of C1s from the macromolecular complex, and (3) C3 and C5 conversion.
D001241:Aspirin / Q000494:pharmacology*; D003167:Complement Activation / Q000187:drug effects*; D003172:Complement C1 / Q000378:metabolism; D003174:Complement C1 Inactivator Proteins / Q000378:metabolism; D003175:Complement C2 / Q000378:metabolism; D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism; D003182:Complement C5 / Q000378:metabolism; D003171:Complement Pathway, Classical / Q000187:drug effects; D003165:Complement System Proteins / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D012980:Sodium Salicylate / Q000494:pharmacology
D003172:Complement C1; D003174:Complement C1 Inactivator Proteins; D003175:Complement C2; D003176:Complement C3; D003181:Complement C4; D003182:Complement C5; D003165:Complement System Proteins; D001241:Aspirin; D012980:Sodium Salicylate