[Intensification of the cytostatic action of adriamycin and carminomycin by amphotericin B].
Amphotericin B has a significant cytostatic effect on lymphadenosis cells of mice NK/LY. In a concentration of 6 units/ml it inhibits an increase in total nucleic acids by 50 per cent. Such cytostatic effect of amphotericin B combines with the effect of carminomycin and adriamycin. In concentrations having no cytostatic effect amphotericin B does not enhance the action of adriamycin and carminomycin on tumor cells.
D000666:Amphotericin B / Q000627:therapeutic use*; D000818:Animals; D002360:Carubicin / Q000627:therapeutic use*; D002478:Cells, Cultured; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004317:Doxorubicin / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004357:Drug Synergism; D066298:In Vitro Techniques; D008223:Lymphoma / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy
D000666:Amphotericin B; D004317:Doxorubicin; D002360:Carubicin; D003630:Daunorubicin
Ob usilenii tsistostaticheskogo deĭstviia adriamitsina i karminomitsina amfoteritsinom B.