Effect of megadoses of ascorbic acid on serum and urinary oxalate.
Serum and urinary oxalate was determined in 9 normal subjects, ingesting 8 g of ascorbic acid daily. Serum oxalate levels increased to 310% of control values during supplementation. Plasma ascrobate levels reached a mean value of 3.6 mg% far exceeding the previously reported plateau level of 1.8 mg%. Urinary oxalate gradually increased during ascorbate intake and 7 days post cessation of ascorbate, rose unexpectedly for all subjects into the hyperoxaluric range.
D000284:Administration, Oral; D000328:Adult; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000378:metabolism*; D002940:Circadian Rhythm; D005260:Female; D006801:Humans; D008297:Male; D010070:Oxalates / Q000097:blood / Q000378:metabolism* / Q000652:urine
D010070:Oxalates; D001205:Ascorbic Acid