title: Effects of centrifugation stress on pituitary-gonadal function in male rats.
abstract: The effects of centrifugation for various lengths of time were investigated on circulating levels of luteinizing hormone (LH) and testosterone in male rats. In a chronic 52-day experiment, centrifugation at 4.1 G significantly reduced LH and testosterone levels for the entire period. Centrifugation at 2.3 G had less effect inasmuch as LH levels were not significantly decreased and testosterone levels were significantly reduced only during the first few days of centrifugation. In more acute experiments, centrifugation at 4.1 G for 4 h resulted in reduced testosterone levels, whereas centrifugation for 15 min did not significantly alter the hormone levels. These results indicate that centrifugation can decrease circulating LH and testosterone levels if the gravitational force is of sufficient magnitude and is maintained for a period of hours. Chronic centrifugation may also inhibit the acute excitatory response of LH to handling and ether stress.
mesh_terms: D000818:Animals; D006112:Gravitation; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D010903:Pituitary Gland, Anterior / Q000503:physiopathology; D051381:Rats; D012399:Rotation / Q000009:adverse effects; D013312:Stress, Physiological / Q000097:blood* / Q000209:etiology / Q000503:physiopathology; D013737:Testis / Q000503:physiopathology; D013739:Testosterone / Q000097:blood*; D013997:Time Factors
chemical_list: D013739:Testosterone; D007986:Luteinizing Hormone