Plasma phase viremia in canine distemper virus infection.
Plasma samples from gnotobiotic pups infected with R252 canine distemper virus at 7 days of age contained free infective virus when titrated on canine pulmonary macrophage cultures. Virus was detected 7 days after infection and increased thereafter. Platelets may be involved in leukocyte-free viremia. The present study indicated that the method of dissemination of the virus in vivo involves plasma and canine distemper virus-infected leukocytes.
D000818:Animals; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral; D004216:Distemper / Q000382:microbiology*; D004217:Distemper Virus, Canine / Q000254:growth & development / Q000302:isolation & purification; D004285:Dogs; D014766:Viremia / Q000382:microbiology / Q000662:veterinary*