Renal compensatory hypertrophy in children with unilateral renal disease.
Kidney parenchymal size was estimated on urograms from 22 children with unilateral vesico-ureteral reflux (VUR), 14 children with bilateral VUR and seven children with unilateral heminephrectomy. In the bilateral VUR group, one kidney was roentgenologically normal and the other was growth-retarded. The GFR was estimated in 19 of the children. The age of the children was 3-17 years and all had a history of urinary tract infection. The size of the smaller kidney varied between 33-97% of normal. Children in the unilateral VUR group with a small kidney due to scarring and/or growth retardation showed a varying degree of compensatory hypertrophy in the contralateral kidney, which was proportional to the parenchymal reduction. This compensation was inhibited in the bilateral VUR group. There was a positive correlation between the GFR and kidney size.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005919:Glomerular Filtration Rate; D006801:Humans; D006984:Hypertrophy; D007668:Kidney / Q000473:pathology*; D007674:Kidney Diseases / Q000473:pathology* / Q000503:physiopathology; D009392:Nephrectomy; D011704:Pyelonephritis / Q000473:pathology; D014718:Vesico-Ureteral Reflux / Q000473:pathology / Q000503:physiopathology