Effect of kainate on ATP levels and glutamate metabolism in cerebellar slices.
The levels of ATP and amino acids were measured in rat cerebellar slices incubated in the presence of the neurotoxin, kainic acid (KA). 0.1--1 mM KA caused a significant decrease in tissue content of ATP, glutamate, aspartate and glutamine. The levels of glutamate and aspartate, but not glutamine, rose concomitantly in the incubation medium. The results are consistent with a multiaction mechanism for the neurotoxicity of KA.
D000255:Adenosine Triphosphate / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D002531:Cerebellum / Q000187:drug effects / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D005973:Glutamine / Q000378:metabolism; D066298:In Vitro Techniques; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D011759:Pyrrolidines / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000596:Amino Acids; D005971:Glutamates; D011759:Pyrrolidines; D005973:Glutamine; D001224:Aspartic Acid; D000255:Adenosine Triphosphate; D007608:Kainic Acid