Effects of vitamin D on the absorption and retention of lead.
A relationship between lead retention and vitamin D has been recognized for many years, but the reasons for this association remained unknown. In rats, the manipulation of dietary vitamin D content had no significant effect on the absorption of lead from isolated gut loops and parenteral vitamin D stimulation did not affect lead absorption in rachitic animals. In contrast, dietary vitamin D deficiency and repletion resulted in increased absorption in intact animals due to prolonged gastrointestinal transit time. Both dietary vitamin D deficiency and repletion were associated with decreased body retention of radiolead given intravenously. Further, single doses of parenteral vitamin D administered to animals previously given tracer radiolead resulted in a dose-related enhancement of lead excretion and changes in tissue lead content.
D000818:Animals; D001842:Bone and Bones / Q000378:metabolism; D004032:Diet; D005769:Gastrointestinal Motility / Q000187:drug effects; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D007854:Lead / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D014018:Tissue Distribution; D014807:Vitamin D / Q000494:pharmacology*; D014808:Vitamin D Deficiency / Q000378:metabolism
D014807:Vitamin D; D007854:Lead