title: Spontaneous cytotoxicity of murine cells treated with the interferon inducers BRL 5907 and BRL 10739.
abstract: The effects of the polyribonucleotide interferon inducers, BRL 5907 and BRL 10739, on the spontaneous cytotoxicity of CBA mouse cells towards the allogeneic lymphoma EL-4, were investigated. Intravenous administration of BRL 5907 and BRL 10739 increased the cytotoxic activity of a non-adherent, theta-negative, surface immunoglobulin-negative cell present in the spleen, but had no effect on cells in the lymph nodes. Spleen cell cytotoxicity was established within 24 h of injection of the polyribonucleotides, but had disappeared by 4 days. In addition, injection of mice with BRL 10739 increased the spontaneous cytotoxicity of a nylon-wool-adherent, theta-positive spleen cell. Intraperitoneal injection of mice with BRL 5907 and BRL 10739 also enhanced the cytotoxic activity of a non-adherent peritoneal exudate cell.
mesh_terms: D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D007369:Interferon Inducers / Q000494:pharmacology*; D008198:Lymph Nodes / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000276:immunology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D012330:RNA, Double-Stranded / Q000494:pharmacology*; D012367:RNA, Viral / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology
chemical_list: D007369:Interferon Inducers; D000644:Quaternary Ammonium Compounds; D012330:RNA, Double-Stranded; D012367:RNA, Viral; C006192:BRL 5907; C006243:BRL 10739