Nomographic estimation of time to reach steady-state serum concentration during phenytoin therapy.
The time to reach steady-state on phenytoin therapy depends on the dose and the pharmacokinetic parameter of the individual patient. A nomogram is presented to help the physician to decide whether a measured serum concentration of phenytoin can be regarded as being within 20% of the steady-state level. The nomogram is based on the pharmacokinetic parameters of phenytoin reported for adult patients.
D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood*; D013997:Time Factors
D010672:Phenytoin