title: Lymphocyte density distribution profile and spontaneous transformation related to the stage of Hodgkin's disease.
abstract: Density distribution profiles of peripheral lymphocytes were made in 41 untreated patients with Hodgkin's disease and in 14 normal controls. The fraction of lymphocytes with a low specific gravity in patients was significantly increased in comparison to normal controls (P=0.0007). These low density lymphocytes in Hodgkin's disease patients showed an elevated spontaneous 3H-thymidine incorporation compared to normal controls (P less than 0.0001). In 78% of the patients the spontaneous DNA synthesis of the low density lymphocytes was above the normal range. A positive correlation (P=0.002) was found between the spontaneous 3H-thymidine uptake and the stage of the disease.
mesh_terms: D000328:Adult; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D005260:Female; D006689:Hodgkin Disease / Q000097:blood / Q000473:pathology*; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D013046:Specific Gravity; D013936:Thymidine / Q000378:metabolism
chemical_list: D004247:DNA; D013936:Thymidine