title: [State of the monooxygenase enzymatic system during chronic diethylnitrosamine administration].
abstract: Content of components and functional activity of monooxygenase enzyme system were studied in rat liver tissue during hepatocarcinogenesis produced by diethyl nitrosamine treatment. Content of cytochromes P-450 and b5, NADPH- NADH-cytochrome c reductase and demethylase activities as well as capacity to induce the monooxygenase enzyme system after administration of its inductors were not altered in chronic treatment with carcinogenic doses of diethyl nitrosamine. The higher doses of the amine were shown to reduce the content of the cytochromes in liver tissue.
mesh_terms: D000818:Animals; D003641:Deamination; D004052:Diethylnitrosamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology; D009602:Nitrosamines / Q000494:pharmacology*; D010105:Oxygenases / Q000096:biosynthesis*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D013997:Time Factors
chemical_list: D009602:Nitrosamines; D004052:Diethylnitrosamine; D008748:Methylcholanthrene; D010105:Oxygenases; D010634:Phenobarbital
vernacular_title: Sostoianie monooksigenaznoĭ fermentnoi sistemy pri khronicheskom vvedenii diétilnitrozamina.