[Teratogenicity of anticonvulsant drugs (author's transl)].
Investigations were done on 111 children of epileptic mothers who used anticonvulsants in 93 pregnancies and none in 18 pregnancies. Hydantoinbarbiturate embryopathy was found in 7.1% after hydantoin monotherapy, in 17.6% after combination of hydantoin and barbiturates or primidone. No embryopathy was seen in children of untreated epileptic mothers. Children of untreated and treated epileptic mothers had an approximately equal frequency of marked single malformations and cerebral damage without dysmorphia. However, malformation and cerebral damage without dysmorphia was found significantly more frequently in children of mothers on anticonvulsant drugs with convulsions during pregnancy as compared to children of mothers without convulsions. Single manifestations and cerebral damage without dysmorphia are probably not caused by anticonvulsants but by convulsions during pregnancy.
D000014:Abnormalities, Drug-Induced / Q000209:etiology*; D000927:Anticonvulsants / Q000009:adverse effects*; D001463:Barbiturates / Q000009:adverse effects; D001925:Brain Damage, Chronic / Q000139:chemically induced; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011324:Primidone / Q000009:adverse effects
D000927:Anticonvulsants; D001463:Barbiturates; D006827:Hydantoins; D011324:Primidone
Zur Teratogenität von Antikonvulsiva.