title: A definition of human fetal apnea and the distribution of fetal apneic intervals during the last ten weeks of pregnancy.
abstract: Fetal breathing movements were studied over 24-hour observation periods for a total of 744 hours in 31 healthy pregnant women at 30 to 39 weeks' gestational age. An analysis of 165,786 breath-to-breath intervals in eight fetuses demonstrated that 97% of breath-to-breath intervals were less than 6 seconds in duration. It was concluded that a breath-to-breath interval of 6 seconds or more is a rational definition of fetal apnea during the last 10 weeks of pregnancy. An analysis of intervals during which time no fetal breathing activity occurred in the 31 fetuses demonstrated that prolonged episodes of apnea were distributed in a similar fashion at different gestational ages. The longest periods of apnea were 65 minutes at 30 to 31 weeks, 105 minutes at 34 to 35 weeks, and 120 minutes at 38 to 39 weeks. No periods of apnea of more than 45 minutes were measured during the second and third hours following maternal meals. A useful strategy for recognition of significant fetal apnea would be to make observations during the second and third hours following maternal meals when apneic lengths greater than 45 minutes were not observed in this highly selected group of normal fetuses.
mesh_terms: D001049:Apnea / Q000503:physiopathology; D005260:Female; D005333:Fetus / Q000502:physiology*; D005865:Gestational Age; D006801:Humans; D011247:Pregnancy; D012119:Respiration; D013997:Time Factors; D014463:Ultrasonography