Cellular events in denervated limb stumps of Ambystoma larvae during re-innervation and subsequent regeneration.
Amputated, denervated Ambystoma forelimbs undergo cellular dedifferentiation and slight resorption through 12 days post-amputation. Subsequently, as limb stumps become re-innervated, there occur mitosis, blastema formation, and regeneration. The initial increase in the mitotic index in once-denervated limb stumps is closely correlated with the presence of ingrowing nerve fibres.
D000557:Ambystoma; D000671:Amputation, Surgical; D000818:Animals; D003714:Denervation; D005121:Extremities / Q000294:innervation / Q000502:physiology*; D007814:Larva / Q000502:physiology; D009416:Nerve Regeneration; D012038:Regeneration