Heavy incorporation of 3H-prostaglandin F2 alpha in the neoplastic cells as revealed by autoradiographic studies.
A marked uptake (9-fold) of the 3H-PGF2 alpha was found specifically over heterochromatin in the nuclei of neoplastic cells. Lower but significant uptakes of 3H-PGF2 alpha were also found in the nuclei of control epidermal cells, which indicate the presence of nuclear receptors in the epidermal neoplastic cells.
D000818:Animals; D001345:Autoradiography; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000378:metabolism* / Q000648:ultrastructure; D002467:Cell Nucleus / Q000378:metabolism*; D006570:Heterochromatin / Q000378:metabolism*; D008297:Male; D008748:Methylcholanthrene; D051379:Mice; D009374:Neoplasms, Experimental / Q000378:metabolism / Q000648:ultrastructure; D011460:Prostaglandins F / Q000378:metabolism*; D012867:Skin / Q000378:metabolism; D014316:Tritium
D006570:Heterochromatin; D011460:Prostaglandins F; D014316:Tritium; D008748:Methylcholanthrene