title: Comparison of two dosage schedules of sustained release theophylline in pediatric patients.
abstract: A sustained release theophylline preparation, administered on a q8h or q12h schedule, was evaluated in 12 severly asthmatic children. Total 24-hour theophylline dosage and peak theophylline levels were significantly higher during the q12h dosage schedule. Trough theophylline levels were similar with the two schedules. Four subjects on the q12h schedule had peak theophylline levels greater than 20 mcg/ml. Pulmonary functions, including FEV1 and MMEF, and the clinical stability of the patients were similar with the two regiments. Other than the higher peak theophylline levels that occurred with the q12h dosing schedule, there were no apparent differences noted between the dosage schedules.
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D001249:Asthma / Q000188:drug therapy*; D002648:Child; D005541:Forced Expiratory Volume; D006801:Humans; D008450:Maximal Midexpiratory Flow Rate; D010349:Patient Compliance; D010366:Peak Expiratory Flow Rate; D013806:Theophylline / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D013806:Theophylline