Possible lack of anticholinergic effects with mianserin: a pilot study.
Anticholinergic effects of mianserin, a new tetracyclic antidepressant, were studied in 5 depressed patients. Prior to and after 1 and 2 hours of the administration of 30 mg of mianserin salivary flow, pupilary response to light and palpebral fissure were measured. Analysis of data revealed a statistically significant increase in salivary flow and a statistically significant decrease in pupil diameter. There was no change in palpebral fissure size. Possible clinical implications of these findings will be discussed.
D000328:Adult; D003863:Depression / Q000188:drug therapy; D003984:Dibenzazepines / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008803:Mianserin / Q000627:therapeutic use*; D008875:Middle Aged; D011950:Receptors, Cholinergic / Q000187:drug effects*; D012025:Reflex, Pupillary / Q000187:drug effects; D012472:Salivation / Q000187:drug effects
D003984:Dibenzazepines; D011950:Receptors, Cholinergic; D008803:Mianserin