Non-competitive inhibition of bradykinin, acetylcholine and histamine on guinea-pig ileum with streptomycin and vitamin K3.
Streptomycin and vitamin K3 were studied on the guinea-pig ileum for their effects on the cumulative dose-response curves of bradykinin, acetylcholine and histamine. Streptomycin and vitamin K3 antagonized each of these agonists non-competitively. The comparison of the non-competitive affinities of the antagonists indicate that all of these agonists antagonized by a common mechanism.
D000109:Acetylcholine / Q000037:antagonists & inhibitors*; D000818:Animals; D001920:Bradykinin / Q000037:antagonists & inhibitors*; D005260:Female; D006168:Guinea Pigs; D006633:Histamine Antagonists; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects*; D013307:Streptomycin / Q000494:pharmacology*; D014812:Vitamin K / Q000494:pharmacology*
D006633:Histamine Antagonists; D014812:Vitamin K; D000109:Acetylcholine; D001920:Bradykinin; D013307:Streptomycin