Early cutback in chemical energy production if the Crocker sarcoma (S180) undergoing haemorrhagic necrosis as a result of endotoxin administration.
Alterations in the tumor adenine nucleotide pattern (TANP) have been measured at various times in a solid murine tumor undergoing haemorrhagic necrosis in vivo as a consequence of endotoxin administration. The ATP level fell rapidly in the first few hours; the AMP content initially rose, but began to fall back at 4 h. Overall adenine nucleotide losses occurred promptly, with only 4% of the original amount remaining at 24 h. Levels of glucose, glucose 6-phosphate, pyruvate, and lactate were also measured, and, with the exception of lactate, were for the most part lower in tumors from endotoxin-treated animals. Only minor alterations in the adenine nucleotide pattern were seen after either 4 or 24 h in the livers of normal or tumor-bearing mice in response to endotoxon injection, even when the creatures were moribund. The changes reported in the tumor are believed to have arisen not as a result of capillary stasis, but from prompt and selective disturbances to mitochondrial function in the tumor which have been described previously (Jones, 1977b, 1979).
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D004731:Endotoxins / Q000494:pharmacology*; D005260:Female; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis; D006470:Hemorrhage / Q000139:chemically induced; D007773:Lactates / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D051379:Mice; D008928:Mitochondria / Q000187:drug effects / Q000378:metabolism; D009336:Necrosis / Q000139:chemically induced; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D012510:Sarcoma 180 / Q000378:metabolism*
D000227:Adenine Nucleotides; D004731:Endotoxins; D007773:Lactates; D005947:Glucose