The effect of cancer chemotherapeutic agents on the liver-spleen scan.
The effects of short-term cancer chemotherapy on the liver-spleen scintiscans of 15 patients were assessed. Half of these exhibited minimal and transient changes in the pattern of radiocolloid distribution and/or chemical liver-function tests. No examples of new focal defects were seen. The data suggest that cytotoxic drugs are capable of inducing minor scan changes that might be attributed erroneously to intrinsic hepatic disease.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001853:Bone Marrow / Q000000981:diagnostic imaging / Q000187:drug effects; D003937:Diagnosis, Differential; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000187:drug effects; D008107:Liver Diseases / Q000000981:diagnostic imaging; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary; D009369:Neoplasms / Q000188:drug therapy / Q000473:pathology; D011877:Radionuclide Imaging; D051381:Rats; D013154:Spleen / Q000000981:diagnostic imaging* / Q000187:drug effects; D013997:Time Factors
D000970:Antineoplastic Agents