Prostaglandin synthetase inhibitor in an infant with congenital chloride diarrhoea.
Hyper-reninaemia, hypokaluria, and hypokalaemia in an infant with congenital chloride diarrhoea improved during treatment with a prostaglandin synthetase inhibitor, ketoprofen. There was evidence of increased activity of therenin-aldosterone system when ketoprofen was stopped. It is suggested that prostaglandins may be involved in stimulating the renin-aldosterone system in congenital chloride diarrhoea.
D002712:Chlorides / Q000032:analysis; D003968:Diarrhea, Infantile / Q000151:congenital* / Q000188:drug therapy; D005243:Feces / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007660:Ketoprofen / Q000627:therapeutic use*; D008297:Male; D010666:Phenylpropionates / Q000627:therapeutic use*
D002712:Chlorides; D010666:Phenylpropionates; D007660:Ketoprofen