title: Complement-mediated reactions to diazepam with Cremophor as solvent (Stesolid MR).
abstract: Changes in complement reactions are described in two patients exhibiting adverse reactions to Stesolid MR (diazepam with Cremophor as solvent). The recorded frequency of adverse reactions to Althesin, propandid and Stesolid MR suggests that the common solvent Cremophor is responsible for the adverse reactions.
mesh_terms: D000328:Adult; D003167:Complement Activation / Q000187:drug effects*; D003176:Complement C3 / Q000032:analysis; D003975:Diazepam / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology*; D005260:Female; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced*; D008297:Male; D011092:Polyethylene Glycols / Q000009:adverse effects*; D012997:Solvents / Q000009:adverse effects*
chemical_list: D003176:Complement C3; D012997:Solvents; C022131:cremophor; D011092:Polyethylene Glycols; D003975:Diazepam