Anatomical distribution of exogenous 14C-oxalate in the rat by macroautoradiography.
A single dose of 14C-oxalate was given to a group of laboratory rats using a gastric tube. The animals were then killed at intervals of 1/2, 2, 5, 24 and 72 h following oxalate administration and the oxalate distribution was determined using the technique of macroautoradiography. The results showed that a large proportion of the absorbed oxalate was already excreted in the bladder 30 min after administration. The non-absorbed oxalate was found eliminated with the faeces after 24 h. At the same time, 14C-oxalate was demonstrated in the bones; whereas 72 h later no radioactivity could be found anymore. It is conceivable, therefore, that the rapid renal excretion of exogenous oxalate may lead to a short-term oxalate peak in the urine. More importantly, the occurrence of such a urinary oxalate peak could in turn be responsible for crystalluria and stone formation.
D000818:Animals; D001345:Autoradiography; D001842:Bone and Bones / Q000378:metabolism; D002250:Carbon Radioisotopes; D005753:Gastric Mucosa / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010070:Oxalates / Q000378:metabolism* / Q000652:urine; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution; D001743:Urinary Bladder / Q000378:metabolism
D002250:Carbon Radioisotopes; D010070:Oxalates