Cyproterone acetate and seminal vesicles in the regulation of male fertility.
The effect of continuous release of microquantities of cyproterone acetate from subcutaneously implanted silastic capsules on the fertility of surgically manipulated seminal vesicles of rat has been studied. The experimental animals showed infertility for 3 weeks, as a consequence of removal of seminal plasma, following which normal fertility returns as efficiently as that operated control. However, a significant decrease in weight of the testes and epididymides, were recorded. It appears that seminal vesicles can synthesize seminal plasma even at very low levels of androgen in the presence of cyproterone acetate.
D000818:Animals; D003534:Cyproterone / Q000008:administration & dosage / Q000494:pharmacology*; D004343:Drug Implants; D005260:Female; D005298:Fertility / Q000187:drug effects*; D005837:Genitalia, Male / Q000187:drug effects / Q000502:physiology; D007248:Infertility, Male / Q000139:chemically induced; D008297:Male; D009929:Organ Size; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects* / Q000378:metabolism
D004343:Drug Implants; D003534:Cyproterone