Phenytoin-misonidazole: possible metabolic interaction.
Following iv administration of misonidazole, evidence of decreased plasma half-life (3.8 hours versus 9.1 hours +/- 0.8 [SD] in eight other patients studied) and increased metabolism was observed in a patient receiving continuous phenytoin therapy.
D004341:Drug Evaluation; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D007263:Infusions, Parenteral; D008099:Liver / Q000378:metabolism; D008920:Misonidazole / Q000008:administration & dosage / Q000378:metabolism*; D009593:Nitroimidazoles / Q000378:metabolism*; D010672:Phenytoin / Q000008:administration & dosage / Q000378:metabolism*
D009593:Nitroimidazoles; D010672:Phenytoin; D008920:Misonidazole