The effects of betamethasone on fetal development in the rabbit.
Pregnant rabbits were injected with either 0.8 mg of betamethasone or with a comparable volume of saline on days 24 and 25 of gestation and delivered by cesarean section on day 26. There was a significant reduction in the weight of fetuses and in the weights of fetal brain, lungs, liver, and placenta in betamethasone-treated animals. With respect to the fetal brain, the concentration of DNA, the average of cell number, cell size, cell weight, and cell phospholipids were unaffected whereas the concentrations of phospholipids and protein were elevated in the treatment group.
D000818:Animals; D001623:Betamethasone / Q000633:toxicity*; D001835:Body Weight; D001921:Brain / Q000196:embryology / Q000378:metabolism; D004247:DNA / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000187:drug effects* / Q000502:physiology; D008099:Liver / Q000196:embryology; D008168:Lung / Q000196:embryology / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010743:Phospholipids / Q000378:metabolism; D010920:Placenta / Q000473:pathology; D011247:Pregnancy; D011817:Rabbits; D012965:Sodium Chloride / Q000494:pharmacology; D013723:Teratogens
D009419:Nerve Tissue Proteins; D010743:Phospholipids; D013723:Teratogens; D012965:Sodium Chloride; D004247:DNA; D001623:Betamethasone