title: Correlations between adenohypophyseal weight, serum polyphenol oxidase activity (ceruloplasmin) and hypothalamic ascorbic acid after estrogen treatment in rats.
abstract: Serum polyphenol oxidase activity (ceruloplasmin) and the hypothalamic ascorbic acid concentration were determined in control rats and rats given estradiol for 2-6 months. A significant positive correlation (r = 0.5948, p less than 0.001) was found between adenohypophyseal weight and the ceruloplasmin level and a negative correlation between adenohypophyseal weight and the ascorbic acid concentration in the hypothalamus (r = -0.5728, p less than 0.01) and between the hypothalamus ascorbic acid concentration and the ceruloplasmin level (r = -0.7059, p less than 0.01). The ways in which an increase in serum polyphenol oxidase activity might modulate the adenohypophyseal reaction to estradiol are discussed.
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D002570:Ceruloplasmin / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009929:Organ Size; D010904:Pituitary Gland, Posterior / Q000033:anatomy & histology / Q000187:drug effects / Q000201:enzymology*; D051381:Rats
chemical_list: D004958:Estradiol; D002570:Ceruloplasmin; D001205:Ascorbic Acid