Transient deficiency of antihemophilic factor (AHF) procoagulant and AHF-like antigen during administration of tetracycline.
A 35-year old woman showed a transient reduction in level of both moieties of antihemophilic factor (AHF; factor VIII, AHG), following the accidental administration of oral tetracycline. This effect could be reproduced under controlled conditions. No anti-AHF antibodies nor antibodies against tetracycline could be demonstrated. It is suspected that the antibiotic temporarily suppressed the biosynthesis of the AHF procoagulant and AHF-like antigen.
D000328:Adult; D000917:Antibody Formation / Q000187:drug effects; D005169:Factor VIII / Q000096:biosynthesis / Q000276:immunology; D005260:Female; D006467:Hemophilia A / Q000139:chemically induced*; D006801:Humans; D013754:Tetracyclines / Q000009:adverse effects* / Q000494:pharmacology; D013918:Thrombin Time
D013754:Tetracyclines; D005169:Factor VIII