title: Influence of cancer chemotherapy treatment on the reticuloendothelial system in the rat.
abstract: The phagocytic function of the reticuloendothelial system (RES) in the rat has been studied after the administration of cyclophosphamide, 5-fluorouracil or a combination of these drugs and vincristine. No impairment in the elimination of 125I-labelled microaggregated human serum albumin was found. A significant reduction in relative and total spleen weight was not paralleled by a decreased splenic uptake of the RES test substance per gram tissue. A significant increase in the relative weight of the lungs was paralleled by a significant increase in the uptake of test substance on a per gram basis. No correr. A general reduction in the cell population of the haematopoietic system has to be assumed. If this reduction is more pronounced in subpopulations of T lymphocytes (suppressor T cells) has to be further tested.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D008297:Male; D012157:Mononuclear Phagocyte System / Q000187:drug effects*; D009929:Organ Size / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D000970:Antineoplastic Agents