The pharmacokinetics of dihydroergotamine in the beagle dog after a single intravenous injection and after a continuous intravenous infusion.
The pharmacokinetics of dihydroergotamine (DHE) was studied in 6 beagles after a single 2.0 mg intravenous dose and after a continuous intravenous infusion (dose 2.0 mg, infusion time 51 min.=2.8-3.5 micrograms/min./kg). The concentrations of DHE in the plasma during 6 hours were determined by a radioimmunoassay. The mean alpha-phase T1/2 was 0.92 min. and 5.93 min., the mean beta-phase T1/2 was 104.42 min. and 115.79 min., and the mean plasma clearance value 202.88 ml/min. and 234.79 ml/min. after a single intravenous injection a continuous infusion administration, respectively. Similarly, the Vdc - values were 0.121/kg and significantly from each other. The simulated concentrations of DHE in the peripheral compartment increased rapidly explaining its fast effect on the vasculature in clinical use.
D000818:Animals; D004087:Dihydroergotamine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D005260:Female; D006207:Half-Life; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male
D004087:Dihydroergotamine