Hydrocortisone-induced inhibitor of prostaglandin biosynthesis in rat leucocytes.
Rat peritoneal luecocytes incubated with hydrocortisone (10 micrograms/ml) release a factor which inhibits prostaglandin generation. The steroid-induced inhibitor, which mediates the anti-phospholipase effect of antiinflammatory steroids, may be a protein or a polypeptide since its formation is blocked by cycloheximide, a known inhibitor of protein synthesis.
D000818:Animals; D001095:Arachidonic Acids / Q000378:metabolism; D003513:Cycloheximide / Q000494:pharmacology; D004347:Drug Interactions; D006854:Hydrocortisone / Q000494:pharmacology*; D066298:In Vitro Techniques; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D011448:Prostaglandin Antagonists / Q000097:blood*; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats
D001095:Arachidonic Acids; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D003513:Cycloheximide; D006854:Hydrocortisone