Comparison of the carcinogenic effects of five nitrosamines in guinea pigs.
Five nitrosamines which were potent carcinogens in rats or hamsters were administered by gavage in olive oil solution twice a week to 20 male strain 2 guinea pigs. Nitroso-2,6-dimethylmorpholine given at 80 mg/kg/week for 12 weeks or at 32 mg/kg/week for 35 weeks gave rise to hemangioendothelial sarcomas of the liver in 6 and 19 animals, respectively. The same tumors were induced in 18 animals by dinitroso-2,6,dimethylpiperazine, together with hepatocellular carcinomas in six animals. Nitrosomethyldodecylamine also induced mainly hemangioendothelial sarcomas of the liver (12 animals). A few bile duct carcinomas were also observed. Neither nitrosoheptamethyleneimine nor nitrosomethyldiethylurea seemed to induce tumors in guinea pigs under our conditions.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004727:Endothelium / Q000187:drug effects; D006168:Guinea Pigs / Q000502:physiology*; D008099:Liver / Q000187:drug effects; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D009602:Nitrosamines / Q000633:toxicity*; D014652:Vascular Diseases / Q000139:chemically induced
D009602:Nitrosamines