Overadditive chemotherapeutic synergism of prospidine and inosine when given sequentially to the Sarcoma 180 implanted intramuscularly.
The chemotherapeutic effectiveness of prospidine monotherapy on the Sarcoma 180 implanted i.m. was compared with several prospidine/inosine combinations. The chemotherapeutic action of the combination was enhanced overadditively when inosine was given 6 h after prospidine. This particular combination caused not only a significant curative action and tumor inhibition as compared with prospidine monotherapy, but also decreased the toxic effects.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004334:Drug Administration Schedule; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D007288:Inosine / Q000008:administration & dosage* / Q000009:adverse effects; D051379:Mice; D010879:Piperazines / Q000008:administration & dosage*; D011447:Prospidium / Q000008:administration & dosage* / Q000009:adverse effects; D012510:Sarcoma 180 / Q000188:drug therapy*
D010879:Piperazines; D007288:Inosine; D011447:Prospidium