Effect of selenium on the contractile force of isolated and perfused guinea-pig heart.
Sodium selenite showed a negative inotropic effect on isolated and perfused guinea-pig heart. The effect was dose-dependent and was not reversed by a higher calcium concentration or by washing. Electronic microscopy revealed mitochondrial alterations. Pyruvate and lactate 2 X 10(-3)M seemed able to reverse the negative inotropic effect and mitochondrial alterations induced by sodium selenite.
D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D007773:Lactates / Q000494:pharmacology; D008297:Male; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000187:drug effects / Q000648:ultrastructure; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000648:ultrastructure; D010477:Perfusion; D011773:Pyruvates / Q000494:pharmacology; D012643:Selenium / Q000494:pharmacology*
D007773:Lactates; D011773:Pyruvates; D012643:Selenium