title: Investigation of a valuable biochemical indicator in radiotherapy. III. Serum lactate dehydrogenase enzyme level on irradiation of cancer patients.
abstract: In search of a valuable indicator of the effects of radiotherapy, the immune answer, leucocyte number, plasma free hemoglobin and serum haptoglobins were studied [3, 7]. Among the enzymes of interest, lactate dehydrogenase (LDH) was chosen for measurements, as it gave significantly elevated values on irradiation of blood, in vitro [6]. In the present study LDH values are shown on irradiation of cancer patients by differing types of radiation sources during treatment for several weeks. In 63% of the cases increase in respect of the untreated control was observed, and this was manifested during 4 or 5 weeks' treatment. "Modern beams", as high-energy X-ray and electron-ray increased LDH enzyme values less than conventional 200-kV X-rays and 60Co-gamma-rays. In the study of LDH isoenzymes, components 4 and 5 gave elevated values, others remained unchanged. Correlation between LDH enzyme and plasma free hemoglobin was estimated.
mesh_terms: D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D004583:Electrons; D006454:Hemoglobins; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D009369:Neoplasms / Q000201:enzymology / Q000532:radiotherapy*; D011867:Radioisotope Teletherapy; D011878:Radiotherapy / Q000379:methods; D011879:Radiotherapy Dosage; D013997:Time Factors
chemical_list: D003037:Cobalt Radioisotopes; D006454:Hemoglobins; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase