title: A highly topically active corticosteroid. Preliminary report.
abstract: The local anti-inflammatory effects of a synthetic corticosteroid, 17 alpha, 21-diacetory-2-bromo-6 beta, 9 alpha-difluoro-11 beta-hydroxy-1,4,-pregnadiene-3,20-dione (F-2), were evaluated by granuloma and granuloma pouch method. F-2 had an intensive and probably persistent topical anti-inflammatory activity. The systemic effects of F-2 were evaluated by measuring the thymus and adrenal gland weight. F-2 did not induce significant systemic effects at as high a dose as 125 times the effective dose.
mesh_terms: D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D005477:Fluprednisolone / Q000031:analogs & derivatives* / Q000494:pharmacology; D006099:Granuloma / Q000503:physiopathology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010209:Paper; D051381:Rats; D013950:Thymus Gland / Q000187:drug effects
chemical_list: C015912:halopredone acetate; D005477:Fluprednisolone