Permanent inhibition of capping of spleen lymphocytes from neonatally oestrogen-treated female mice.
Female mice of the NMRI strain were injected with 5 microgram diethylstilboestrol (DES) or oestradiol-17 beta for the first 5 days after birth. Controls were given olive oil only. At the age of 4-6 months, the spleen lymphocyte population from the DES females had about half the percentage of cells undergoing capping after exposure to concanavalin A (Con A) as controls. The results from the oestradiol-injected females varied. After treatment of lymphocytes from DES females with colchicine, the percentage cells capping was as in control females. Binding studies did not reveal any difference in Con A receptor affinity or receptor number between DES females and controls.
D000818:Animals; D003078:Colchicine / Q000494:pharmacology; D004054:Diethylstilbestrol / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007152:Immunologic Capping / Q000187:drug effects*; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D011952:Receptors, Concanavalin A / Q000187:drug effects; D013154:Spleen / Q000166:cytology
D011952:Receptors, Concanavalin A; D004958:Estradiol; D004054:Diethylstilbestrol; D003078:Colchicine