title: Potentiation of pentobarbitone sleeping time by chloroquine in the rat.
abstract: The effects of chronic administration of chloroquine on pentobarbitone sleeping time was studied in albino rats. Administration of chloroquine (20 mg/kg s.c.) for 21 days significantly increased pentobarbitone sleeping time by 16--105% within that period. A combination of chloroquine (20 mg/kg s.c.) and pentobarbitone (20 mg/kg s.c.) not only antagonised the usual decreased pentobarbitone sleeping time when pentobarbitone is given alone but also increased it by 34--56% within 7--14 days. In chloroquine chronic pretreated rats injection of sub-anaesthetic doses of pentobarbitone (20 mg/kg i.p.) produced anaesthesia for 42.15 +/- 4.6 min while untreated rats became only ataxic. It has been suggested that these effects of chloroquine may be due to a decrease in the metabolism of pentobarbitone in the liver.
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors
chemical_list: D002738:Chloroquine; D010424:Pentobarbital