Induction of nucleolar segregation in adrenal fasciculata cells by actinomycin D.
Actinomycin D administration to young rats provokes segregation of the nucleoli of adrenal fasciculata cells into 5 distinct zones (granular, fibrillar and vacuolar zones, a fibrillar center, and a dense fibrillar or "contrasted" zone); in the cytoplasm, there were dilations of Golgi cisternae. In spite of the nucleolar segregation, the cytoplasmic alterations suggest the maintenance of protein synthesis.
D000302:Adrenal Cortex / Q000187:drug effects / Q000473:pathology*; D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects*; D003593:Cytoplasm / Q000187:drug effects*; D003609:Dactinomycin / Q000494:pharmacology*; D051381:Rats
D003609:Dactinomycin