Studies on the effects of in vitro ageing on saturable and nonsaturable sugar uptake in cultured human skin fibroblasts.
The Vmax for saturable (i.e. 2-deoxy-D-glucose) sugar transport in cultured human fibroblasts was found to increase with in vitro ageing when the results were expressed per 10(6) cells. No age-related changes were observed in the Km for 2-deoxy-D-glucose transport or in nonsaturable (i.e. L-glucose) sugar uptake.
D000328:Adult; D001692:Biological Transport; D002455:Cell Division; D002462:Cell Membrane / Q000378:metabolism; D002470:Cell Survival; D002478:Cells, Cultured / Q000378:metabolism; D003837:Deoxy Sugars / Q000378:metabolism*; D003847:Deoxyglucose / Q000378:metabolism*; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000378:metabolism
D003837:Deoxy Sugars; D003847:Deoxyglucose; D005947:Glucose