Endothelial cells of bovine pulmonary artery lack receptors for C3b and for the Fc portion of immunoglobulin G.
Bovine pulmonary endothelial cells do not possess receptors for the 3b component of complement (C3b) or for the Fc portion of immunoglobulin G. The lack of these receptors may help explain the nonthrombogenic function of endothelial cells. Our findings rule out the possibility that endothelial cells participate in pulmonary immune complex disease through the binding of C3b or Fc fragments.
D000818:Animals; D002417:Cattle; D002478:Cells, Cultured; D003179:Complement C3b / Q000378:metabolism; D004727:Endothelium / Q000276:immunology; D011651:Pulmonary Artery / Q000276:immunology* / Q000378:metabolism; D011951:Receptors, Complement / Q000378:metabolism*; D011961:Receptors, Fc / Q000378:metabolism*; D012397:Rosette Formation
D011951:Receptors, Complement; D011961:Receptors, Fc; D003179:Complement C3b