[Infantile portal hypertension. Experimental studies on the hemodynamics of various shunt models and clinical study of prehepatic infantile portal hypertension].
The experiments are based on an analysis of the literature on more than 2000 cases of portal hypertension in childhood. The purpose of the experimental model was to test and compare the hemodynamic effects of shunt operations performed in the clinic. In 24 dogs (29 +/- 5,7 kg) general and intestinal hemodynamics were measured during acute prehepatic portal hypertension before and after mesentericocaval, splenorenal, and splenocaval shunt. From the hemodynamic point of view the splenocaval shunt is superior because of its complete venous decompression of the region of spleen and cardia and greater blood flow to the liver. Furthermore shunt flow, and consequently volume load imposed on the general circulation, are significantly smaller in splenocaval shunt.
D000818:Animals; D001166:Arteriovenous Shunt, Surgical; D001201:Ascites / Q000209:etiology; D001810:Blood Volume; D002302:Cardiac Output; D002648:Child; D003097:Collateral Circulation; D004285:Dogs; D006801:Humans; D006975:Hypertension, Portal / Q000473:pathology*; D008103:Liver Cirrhosis / Q000150:complications; D013163:Splenomegaly / Q000209:etiology
Portale Hypertension im Kindesalter. Experimentelle Untersuchungen zur Hämodynamik verschiedener Shunt-Modelle und klinische Beobachtungen der prähepatisch bedingten portalen Hypertension im Kindesalter.