Bone remodeling in centrifuged rats: histomorphometric study after an 18-day run.
A histomorphometric and histodynamic study of bone tissue was conducted in rats exposed to 2 G centrifugation for a period of 18 d. Shortening of the femurs was observed, associated with alterations of the growth cartilage in centrifuged animals. The morphometric analysis demonstrates a reduction in bone volume without increase in the activity of osteoclasts. The fluorescent fixation during the dynamic study shows a reduced appositional rate. This result seems to reflect the numerous factors which contribute to the experimental centrifugation test: the osteoporosis is cortisone induced; it is a response to the aggression and probably conceals the remodeling due to higher stress loads.
D000818:Animals; D000886:Anthropometry; D001835:Body Weight; D001862:Bone Resorption; D001842:Bone and Bones / Q000033:anatomy & histology*; D005260:Female; D006112:Gravitation; D010012:Osteogenesis; D051381:Rats; D012399:Rotation; D013314:Stress, Mechanical