title: Correlation of serum theophylline levels with inhibition of allergen and histamine-induced skin tests.
abstract: The purpose of this study was to determine if clinically effective serum levels of theophylline have an inhibitory effect on intradermal tests for allergic hypersensitivity. Intradermal testing using the threshold-dilution technique was performed in 9 patients, 7 of whom were sensitive to 2 antigens. Testing was performed over a 6-hour period after theophylline administration and compared with the control results. Inhibition of the end-point was demonstrated with 12 of 16 antigens tested associated with serum theophylline levels ranging from 7 to 20 microgram/ml. Marked inhibition of the intradermal tests, that might have clinical significance, only occurred with 4 antigens.
mesh_terms: D000485:Allergens / Q000008:administration & dosage; D006632:Histamine; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis*; D007428:Intradermal Tests; D012882:Skin Tests; D013806:Theophylline / Q000097:blood*; D013997:Time Factors
chemical_list: D000485:Allergens; D006632:Histamine; D013806:Theophylline