Participation of granulocytes and humoral factors in resolution of platelet aggregates during endotoxemia.
Hydrogen peroxide generated by phagocytizing granulocytes can prevent platelet aggregation induced by ADP or collagen but not by endotoxin. Endotoxin tolerance enhances granulocyte mobilization in response to endotoxin and reduces aggregation induced by endotoxin but not ADP or collagen.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D003094:Collagen / Q000494:pharmacology; D004731:Endotoxins / Q000494:pharmacology*; D006098:Granulocytes / Q000502:physiology*; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007108:Immune Tolerance; D007962:Leukocytes / Q000502:physiology; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits
D004731:Endotoxins; D000244:Adenosine Diphosphate; D003094:Collagen; D006861:Hydrogen Peroxide