title: Bone mineral status in growth hormone deficiency.
abstract: Bone mineral status was monitored by photon absorptiometry in 18 children with growth hormone deficiency. Before exogenous growth hormone therapy, bone mineral content, bone width, and BMC/BW were below predicted values. Delayed maturation, as assessed by skeletal age, accounted for approximately 35% of the deficit for these values. Height velocity doubled during therapy, and BMC, BW, and BMC/BW increased commensurate with height and weight increases so that the relative deficit was unchanged. The pathogenesis of relative osteopenia in growth hormone deficiency was not determined.
mesh_terms: D000293:Adolescent; D000365:Age Determination by Skeleton; D001842:Bone and Bones / Q000032:analysis* / Q000033:anatomy & histology / Q000187:drug effects; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000172:deficiency* / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000627:therapeutic use; D008297:Male; D008722:Methods; D008903:Minerals / Q000032:analysis*
chemical_list: D008903:Minerals; D013006:Growth Hormone; D006854:Hydrocortisone