The significance of multiple detoxification pathways for reactive metabolites in the toxicity of 1,1-dichloroethylene.
D000818:Animals; D001711:Biotransformation; D004000:Dichloroethylenes / Q000378:metabolism* / Q000633:toxicity; D004852:Epoxy Compounds / Q000494:pharmacology* / Q000633:toxicity; D004988:Ethers, Cyclic / Q000494:pharmacology*; D005978:Glutathione / Q000032:analysis / Q000378:metabolism; D006843:Hydrocarbons, Chlorinated / Q000378:metabolism*; D008658:Inactivation, Metabolic; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D008297:Male; D008298:Maleates / Q000494:pharmacology / Q000633:toxicity; D008433:Mathematics; D011409:Propylene Glycols / Q000494:pharmacology; D051381:Rats; D013438:Sulfhydryl Compounds / Q000032:analysis; D013439:Sulfhydryl Reagents / Q000494:pharmacology*; D013997:Time Factors; D000637:Transaminases / Q000097:blood
D004000:Dichloroethylenes; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D006843:Hydrocarbons, Chlorinated; D008298:Maleates; D011409:Propylene Glycols; D013438:Sulfhydryl Compounds; D013439:Sulfhydryl Reagents; D000637:Transaminases; D005978:Glutathione