The significance of the Na+/K+ pump for somatostatin release.
The influence of the Na+/K+ pump on somatostatin secretion from the isolated perfused canine pancreas was investigated. The somatostatin secretion was reversibly increased in response to addition of ouabain (10(-5) mol/l) and to omission of extracellular K+, procedures which are known to cause a blockade of the Na+/K+ pump. The stimulatory effect on somatostatin release was abolished during calcium depletion. The results suggest that the operation of the Na+/K+ pump plays an important role for the somatostatin secretion. The action of the Na+/K+ pump on the secretory function of the D-cells is dependent on the presence of extracellular calcium.
D000818:Animals; D002118:Calcium / Q000502:physiology; D004285:Dogs; D066298:In Vitro Techniques; D010042:Ouabain / Q000494:pharmacology; D010179:Pancreas / Q000378:metabolism; D010477:Perfusion; D011188:Potassium / Q000494:pharmacology*; D012964:Sodium / Q000494:pharmacology*; D013004:Somatostatin / Q000378:metabolism*
D013004:Somatostatin; D010042:Ouabain; D012964:Sodium; D011188:Potassium; D002118:Calcium