Bronchial adenoma resection with relief of hypoxic pulmonary vasoconstriction.
Experimental airway obstruction is known to cause reflex pulmonary artery constriction, but clinical documentation of reversible bronchial obstruction and vasoconstriction is rare. A soft bronchial adenoma obstructed the left main bronchus, and scans showed minimal ventilation and perfusion on the left. Gas aspirated from beyond the tumor was hypoxic. The adenoma was removed and the lung left intact by means of a skin graft in the bronchial wall. Four months later, pulmonary function was normal, and both ventilation and perfusion of the left lung were normal. Reflex pulmonary vasoconstriction resulting from alveolar hypoxia minimizes systemic hypoxemia and also minimizes alveolar tissue hypoxia in the lung itself. The reflex is seen most frequently in perfusion scans in patients with chronic airways disease. This case in important in that it documents reversal of vasoconstriction after ventilation was restored.
D000236:Adenoma / Q000000981:diagnostic imaging / Q000601:surgery*; D000328:Adult; D000402:Airway Obstruction / Q000000981:diagnostic imaging / Q000601:surgery; D001984:Bronchial Neoplasms / Q000000981:diagnostic imaging / Q000601:surgery*; D006801:Humans; D000860:Hypoxia / Q000000981:diagnostic imaging / Q000601:surgery*; D008297:Male; D011652:Pulmonary Circulation; D011877:Radionuclide Imaging; D012018:Reflex / Q000502:physiology; D014661:Vasoconstriction; D014692:Ventilation-Perfusion Ratio