title: [Pharmacokinetic problems in surgery].
abstract: The article deals with the shortcomings of pharmacokinetic models in predicting tissue-concentrations of drugs. Several examples are shown from our group that cooperation of surgeons and pharmacokinetic researchers is necessary to overcome these shortcomings.
mesh_terms: D001682:Biological Availability; D002315:Cardiopulmonary Bypass; D002512:Cephalothin / Q000378:metabolism; D004077:Digoxin / Q000378:metabolism; D005665:Furosemide / Q000378:metabolism; D006801:Humans; D006852:Hydrochlorothiazide / Q000378:metabolism; D007408:Intestinal Absorption; D007583:Jejunum / Q000601:surgery; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013514:Surgical Procedures, Operative; D014018:Tissue Distribution
chemical_list: D004364:Pharmaceutical Preparations; D006852:Hydrochlorothiazide; D004077:Digoxin; D005665:Furosemide; D002512:Cephalothin
vernacular_title: Chirurgie und Pharmakokinetik.