title: [Convulsive syndrome activation in mice after administration of ADPT vaccine].
abstract: The experimental model of chemical convulsions allowed to establish the fact that the death of mice immunized with adsorbed DPT vaccine was accelerated, in comparison with the control group, as a result of convulsive fits caused by the injection of thiosemicarbazide. Immunization with adsorbed DPT vaccine was also found to induce a qualitative change in convulsive fits. The fact that an increase in convulsive activity occurs in the animals immunized with absorbed DPT vaccine may be related to the appearance of some forms of convulsive states in children during the postvaccination period.
mesh_terms: D000818:Animals; D002648:Child; D004168:Diphtheria Toxoid / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D051379:Mice; D010567:Pertussis Vaccine / Q000008:administration & dosage / Q000009:adverse effects*; D012640:Seizures / Q000139:chemically induced / Q000209:etiology*; D012663:Semicarbazides; D013577:Syndrome; D013745:Tetanus Toxoid / Q000008:administration & dosage / Q000009:adverse effects*; D014611:Vaccination
chemical_list: D004168:Diphtheria Toxoid; D010567:Pertussis Vaccine; D012663:Semicarbazides; D013745:Tetanus Toxoid; C005151:thiosemicarbazide
vernacular_title: Aktivatsiia sudorozhnogo sindroma u mysheĭ pri vvedenii AKDS-vaktsiny.