The presence of androgen-binding receptors in genital and nongenital skin fibroblasts.
The specific, receptor-dependent 5 alpha-dihydrotestosterone-binding capacity of cultured fibroblasts derived from genital and nongenital skin has been compared. With the methods employed, the detectable amount of the DHT receptor in nongenital skin-derived fibroblasts is variable, often approaching the limit of detectability. Therefore it is concluded that for differential diagnosis of disorders of sexual development, DHT-binding studies should be performed with genital skin fibroblasts only.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D002675:Child, Preschool; D013196:Dihydrotestosterone / Q000378:metabolism; D012734:Disorders of Sex Development / Q000175:diagnosis; D005260:Female; D005347:Fibroblasts / Q000378:metabolism*; D005835:Genitalia / Q000378:metabolism*; D006801:Humans; D007223:Infant; D008297:Male; D011944:Receptors, Androgen / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D012867:Skin / Q000166:cytology* / Q000378:metabolism
D011944:Receptors, Androgen; D011987:Receptors, Steroid; D013196:Dihydrotestosterone