Development of angiotensin-induced drinking in the rat.
The suckling rat responds from birth to intraventricular angiotensin, and the drinking behavior elicited by the hormone achieves adult characteristics of reliability and sensitivity at 4--5 days of age. Additional testing of 5-day-old rats injected with a range of doses showed that the threshold dose lies between 0.1--1.0 ng, which is comparable to the adult sensitivity to intraventricular injections. The hormone also increases milk intake in neonates, but the animals choose water over milk as early as 17 days.
D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D004305:Dose-Response Relationship, Drug; D004326:Drinking / Q000187:drug effects*; D007276:Injections, Intraventricular; D051381:Rats
D000804:Angiotensin II