title: Antipyrene clearance in Indian villagers.
abstract: 1 Antipyrine clearance has been measured using saliva samples in 50 Maharashtrans from a village to the north of Bombay. 2 All subjects were very lean and were also anaemic probably as a result of hookworm infestation. 3 Antipyrine clearance was 36% faster than in White Londoners studied previously and more than twice as fast as in Asian immigrants living in London. 4 Clearance was 25% faster in men than in women but volume of distribution was also greater in men and mean half-lives did not differ significantly between the sexes. 5 There was a negative correlation between antipyrine clearance and haemoglobin concentration. 6 The study has identified geographic differences in antipyrine metabolism which could be clinically important. The role of anaemia merits further study.
mesh_terms: D000328:Adult; D000983:Antipyrine / Q000378:metabolism*; D004032:Diet; D005260:Female; D006207:Half-Life; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D007194:India; D008297:Male; D008875:Middle Aged; D012463:Saliva / Q000378:metabolism; D012737:Sex Factors
chemical_list: D006454:Hemoglobins; D000983:Antipyrine