Interactions between vasopressin and glucagon on ketogenesis and oleate metabolism in isolated hepatocytes from fed rats.
Vasopressin (10nM) inhibited ketogenesis (56%) in hepatocytes from fed rats when oleate (1 mM) was the substrate, but had no effect with butyrate (10mM). The hormone increased the accumulation of lactate and stimulated the esterification of [1(-14)C]oleate (70%). These effects of vasopressin were reversed by glucagon (10 nM). The physiological implications of these findings are discussed.
D000818:Animals; D002087:Butyrates / Q000378:metabolism; D004347:Drug Interactions; D005260:Female; D005934:Glucagon / Q000494:pharmacology*; D005947:Glucose / Q000096:biosynthesis; D066298:In Vitro Techniques; D007657:Ketone Bodies / Q000096:biosynthesis*; D007773:Lactates / Q000096:biosynthesis; D008099:Liver / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009829:Oleic Acids / Q000378:metabolism*; D051381:Rats; D014667:Vasopressins / Q000494:pharmacology*
D002087:Butyrates; D007657:Ketone Bodies; D007773:Lactates; D009829:Oleic Acids; D014667:Vasopressins; D005934:Glucagon; D005947:Glucose