Differential susceptibility of 3 sublines of C57BL/6 mice to the induction of colorectal tumors by 1,2-dimethylhydrazine.
Eight-week-old mice of 3 sublines of strain C57BL/6 were given s.c. injections of 1,2-dimethylhydrazine (DMH), once weekly for 10 weeks. The highest incidence (85%) of colorectal tumors occurred in C57BL/6N mice. Colorectal tumors occurred in 43% of C57BL/6J mice, while only 3 (10%) C57BL/6Ha mice developed these tumors. Possible factors responsible for the differential susceptibility of 3 sublines of C57BL/6 mice to the induction of colorectal tumors by DMH are discussed.
D000230:Adenocarcinoma / Q000139:chemically induced*; D000236:Adenoma / Q000139:chemically induced*; D000818:Animals; D003110:Colonic Neoplasms / Q000139:chemically induced*; D004127:Dimethylhydrazines / Q000008:administration & dosage / Q000633:toxicity*; D004198:Disease Susceptibility; D007279:Injections, Subcutaneous; D008763:Methylhydrazines / Q000633:toxicity*; D051379:Mice; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000139:chemically induced; D012004:Rectal Neoplasms / Q000139:chemically induced*
D004127:Dimethylhydrazines; D008763:Methylhydrazines