The metabolic effects of abdominal irradiation in man with and without dietary therapy with an elemental diet.
The metabolic effects of abdominal radiotherapy were assessed in patients with pelvic neoplasms, and the effects of supplementation of the diet with an 'elemental' diet assessed. Therapeutic irradiation led to significant mean weight losses of 1.4 kg in control patients and 1.0 kg in patients receiving 'elemental' diet supplements. Irradiation was associated with small falls in plasma potassium and calcium concentrations in both groups. In the 'elemental' group there was a small increase in circulating alanine and insulin concentrations and a fall in glycerol and ketone body concentrations, but all variables remained within or close to normal basal reference ranges. Plasma albumin fell slightly but significantly in the 'elemental' diet group from 44 +/- 1 to 42 +/- 1 g/litre during treatment. Is is concluded that modern radiotherapy is no more than a modest catabolic stimulus. Long-term dietary supplementation with 'elemental' diets in ill subjects did not produce adverse effects.
D000368:Aged; D001835:Body Weight / Q000528:radiation effects; D005260:Female; D005526:Food, Formulated; D006801:Humans; D008297:Male; D008875:Middle Aged; D010386:Pelvic Neoplasms / Q000097:blood / Q000532:radiotherapy*; D011832:Radiation Injuries / Q000097:blood / Q000178:diet therapy*; D011897:Random Allocation; D013997:Time Factors