G-cell population and serum gastrin response to cimetidine-OXO test meal in relation to histopathological alterations in resected stomachs from patients with peptic ulcer disease.
The relationship between histopathological alterations and G-cell population in the stomach was studied in l4 resected stomachs from patients with chronic peptic ulcer disease (6 with duodenal ulcer and 8 with gastric ulcer). G-cells were identified by indirect immunoperoxidase method. When atrophy was graded three steps (0, 1, 2), the average grade of DU and GU was 0.23 and 0.89, respectively. There was a significant correlation (r=0.871, p less than 0.005) between atropic grade and G-cell population in each stomach. The mean occupation rate with intestinal metaplasia was 0.9% in DU and 35.8% in GU. There was no correlation between total pyloric area and G-cell population, however residual pyloric area excluding intestinal metaplasia correlated significantly with G-cell population (r=0.557, p less than 0.05). There was a significant difference in the mean G-cell population which were 26.5 millions in DU and 8.9 millions in GU. The mean integrated gastrin response to Cimetidine-OXO test meal were 559+/-236 pg/ml in DU and 216+/-124 pg/ml in GU, and there was significant correlation (r=0.889, p less than 0.005) between G-cell population and integrated gastrin response. The average age of both groups, however, was 27.7 in DU and 52.8 in GU, so that these differences of G-cell population and functional G-cell mass in both groups might originate in the histopathological alterations accompanying with the aging.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002838:Chromaffin System / Q000473:pathology*; D002927:Cimetidine; D004381:Duodenal Ulcer / Q000473:pathology; D004759:Enterochromaffin Cells / Q000473:pathology*; D005753:Gastric Mucosa / Q000473:pathology; D005755:Gastrins / Q000378:metabolism*; D006146:Guanidines; D006801:Humans; D008875:Middle Aged; D010437:Peptic Ulcer / Q000097:blood / Q000473:pathology*; D011708:Pylorus / Q000473:pathology; D013270:Stomach / Q000473:pathology*; D013276:Stomach Ulcer / Q000473:pathology
D005755:Gastrins; D006146:Guanidines; D002927:Cimetidine