Changes in the properties of human fibroblasts in culture after treatment with vitamin A palmitate.
The behaviour of subcultures of vitamin A-treated human embryo fibroblasts was studied from the point of view of morphology, growth characteristics, karyology and agglutinability at subsequent passages after treatment. Evidence was obtained that vitamin A-induced rupture of lysosomes may lead to transient alterations in the pattern of growth, structure of the membranes and morphology in cell generations deriving from the cells injured by the action of the vitamin.
D000135:Acid Phosphatase / Q000378:metabolism; D002449:Cell Aggregation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002877:Chromosomes, Human; D003208:Concanavalin A / Q000494:pharmacology; D004224:Diterpenes; D005347:Fibroblasts / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D008247:Lysosomes / Q000187:drug effects*; D010168:Palmitates / Q000494:pharmacology; D000084562:Retinyl Esters; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology; D014807:Vitamin D / Q000494:pharmacology
D004224:Diterpenes; D010168:Palmitates; D000084562:Retinyl Esters; D003208:Concanavalin A; D014801:Vitamin A; D014807:Vitamin D; C014794:retinol palmitate; D000135:Acid Phosphatase