Intravenous azlocillin kinetics in patients on long-term hemodialysis.
The kinetics of the antipseudomonas penicillin, azlocillin, was studied after intravenous injection in 9 patients with creatinine clearance under 7 ml/min. All were on long-term hemodialysis; 3 were also studied during a dialysis-free period. Kinetic parameters were derived using a 2-compartment open model. The mean serum azlocillin half-life (t 1/2) was 1.93 hr in patients on dialysis and approximately 5 hr off dialysis. Thirty percent of the dose was recovered in the dialysate during a 4-hr period. An approach to the use of azlocillin in patients undergoing dialysis is presented.
D000328:Adult; D001390:Azlocillin; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D007700:Kinetics; D008954:Models, Biological; D010406:Penicillins / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D006435:Renal Dialysis
D010406:Penicillins; D001390:Azlocillin