Supersensitivity after intraventricular 6-hydroxydopamine: relation to dopamine depletion.
6-Hydroxydopamine increased behavioral response to L-DOPA in proportion to the decrease of dopamine (DA) and DA utake in rat striatum. The increase response to apomorphine, however, only occurred after greater than 80% DA loss. Thus, 6-hydroxydopamine may induce postsynaptic changes only following large lesions.
D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D001522:Behavior, Animal / Q000187:drug effects*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D003891:Desipramine / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D005247:Feeding Behavior / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology*; D007700:Kinetics; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D010293:Pargyline / Q000494:pharmacology; D051381:Rats
D006892:Hydroxydopamines; D007980:Levodopa; D010293:Pargyline; D000262:Adenylyl Cyclases; D001058:Apomorphine; D003891:Desipramine; D004298:Dopamine