title: Single-dose parenteral antibiotics as prophylaxis against wound infections in colonic operations.
abstract: A study of 77 patients undergoing elective operations on the colon and rectum, where wounds were subject to contamination by fecal flora, did not demonstrate that the addition of a preoperative oral regime to parenteral antibiotics alone further decreased the incidence of wound infection. The authors feel that the use of single-dose clindamycin and cephazolin intravenously preoperatively has been shown to be a very effective method of preventing wound infection in elective colonic resections.
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D002437:Cefazolin / Q000008:administration & dosage; D002981:Clindamycin / Q000008:administration & dosage; D003106:Colon / Q000601:surgery*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage; D008875:Middle Aged; D009355:Neomycin / Q000008:administration & dosage; D012007:Rectum / Q000601:surgery; D013530:Surgical Wound Infection / Q000517:prevention & control*
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D002981:Clindamycin; D009355:Neomycin; D002437:Cefazolin