High-pressure liquid chromatographic analysis of pramoxine hydrochloride in high lipoid aerosol foam dosage form.
A rapid and quantitative method for the determination of pramoxine hydrochloride by high-pressure liquid chromatography is presented. The drug is extracted as the salt from a preparation with a high lipoid composition by partitioning it to the aqueous phase of an ether-methanol-water-acetic acid system. The extract is chromatographed on an octadecylsilane bonded packing with a methanol-water-acetic acid-methanesulfonic acid mobile phase. The time required for each separation is approximately 6 min. Analytical recoveries of 100.4 +/- 1.5% were obtained.
D000336:Aerosols; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D008055:Lipids; D009025:Morpholines / Q000032:analysis*
D000336:Aerosols; D008055:Lipids; D009025:Morpholines; C005548:pramoxine