title: Variable activity of disophenol against hookworms and lice of northern fur seal pups on St. Paul Island, Alaska.
abstract: Six critical tests with disophenol were conducted in July, 1978, in fur seal pups (Callorhinus ursinus) naturally-infected with adult hookworms, Uncinaria lucasi, and infested with various stages of two species of sucking lice, Proechinopthirus fluctus (Ferris) and Antarctophthirus callorhini (Osborn). Disophenol at a dose rate of 12.5 mg/kg was administered subcutaneously to each of six pups. Each pup was contained in an individual cage for 60 h posttreatment at which time pups were exmained at necropsy. Efficacy against hookworms ranged from 2% to 88% and of both species of lice ranged from 26% to 90% for the six pups. Disophenol removed approximately 90% of all adult lice but only slightly more than 60% of all nymphs. The only sign of toxicosis was a probable drug related fluid-like feces for four pups from 12 to 60 h posttreatment.
mesh_terms: D000413:Alaska; D000818:Animals; D010872:Caniformia / Q000469:parasitology; D046069:Fur Seals / Q000469:parasitology; D006725:Hookworm Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D010373:Lice Infestations / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D009596:Nitrophenols / Q000627:therapeutic use*
chemical_list: D009596:Nitrophenols; C004862:disophenol