The association between urinary sodium excretion and blood pressure in children.
This study explored the association between sodium excretion and blood pressure (BP). A new method was used to minimize the measurement error introduced by the large intrinsic variability of 24-hour sodium excretion. The ratio of intra- to interindividual variation was used to estimate the number of measurements needed to characterize the individual. When seven consecutive 24-hour samples were collected from 73 children, ages 11-14 years, a significant correlation between mean individual sodium excretion and BP was demonstrated. The independent relationship persisted when controlling for height, weight, pulse, age, sex and race (p = 0.045), but was eliminated by simultaneously considering mean creatinine excretion. Although the cross-sectional association described is quantitatively weak, a linear relationship between BP and sodium over the range consumed in this society could be important for prevention.
D000293:Adolescent; D001794:Blood Pressure; D001827:Body Height; D001835:Body Weight; D002648:Child; D003404:Creatinine / Q000652:urine; D003431:Cross-Cultural Comparison; D004032:Diet; D005260:Female; D006339:Heart Rate; D006801:Humans; D008297:Male; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000652:urine*; D013997:Time Factors
D012964:Sodium; D003404:Creatinine; D011188:Potassium