[Bioavailability of monofluoride preparations for dental caries prophylaxis (author's transl)].
Three different preparations containing 1 mg fluoride were given to 12 volunteers: preparation A, 1 hydrous solution, = 1 mg F-/100 ml, preparation B = 2 tablets at 0.5 mg F- and preparation C = 1NaF tablet with 1 mg F-. Representactive kinetic data could be obtained by means of restricted fluoride in the diet, a reproducible method yielding minimum detectable fluoride concentration and selection of suitable volunteers.. The enteral absorption of fluoride from solution A was more rapid (half-life of invasion = 20.2 min and 16.9 min, respectively). The delayed release is a consequence of the galenic mixture. In addition, the maximum concentration in plasma was greater and was reached sooner in preparation A when compared to the other preparations. In contrast, there was no difference in the areas under the curves, indicating that the relative bioavailability of fluoride is the same in all preparations.
D000328:Adult; D001682:Biological Availability; D003731:Dental Caries / Q000517:prevention & control*; D005459:Fluorides / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D008297:Male; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D013997:Time Factors
D012969:Sodium Fluoride; D005459:Fluorides
Untersuchungen zur relativen Bioverfügbarkeit von Monofluorpräparationen zur Zahnkariesprophylaxe.