title: Half-life of angiotensin II in the conscious and barbiturate-anaesthetized rat.
abstract: The half-life (T 1/2) of angiotensin II was measured in rats with chronic indwelling catheters. In conscious animals T 1/2 was 14.8 +/- 2.5 s; during anaesthesia T 1/2 increased by 60%. Anaesthesia decreased the control arterial pressure, but did not alter the sensitivity to injected angiotensin II. The causes and consequences of this change in angiotensin catabolism are discussed.
mesh_terms: D000768:Anesthesia, General; D000804:Angiotensin II / Q000097:blood*; D000818:Animals; D001794:Blood Pressure; D005260:Female; D006207:Half-Life; D007700:Kinetics; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats
chemical_list: D000804:Angiotensin II; D010424:Pentobarbital