Rapid leucine-enkephalin synthesis.
Leucine-enkephalin, a naturally occurring pentapeptide with morphine-like activity, has been synthesized by a fragment condensation liquid phase method using 1,3,4-trimethyl-delta 3-phospholene-1,1-dichloride as a coupling agent. The advantages of this method are discussed.
D000595:Amino Acid Sequence; D004743:Enkephalin, Leucine; D004745:Enkephalins / Q000138:chemical synthesis; D007202:Indicators and Reagents; D008722:Methods; D009943:Organophosphorus Compounds
D004745:Enkephalins; D007202:Indicators and Reagents; D009943:Organophosphorus Compounds; C023574:1,3,4-trimethyl-delta(3)-phospholene-1,1-dichloride; D004743:Enkephalin, Leucine