Evaluation of the humoral response of meningioma patients to possible common tumour-associated antigens.
The humoral response of 39 meningioma patients to possible tumourassociated antigens was studied by means of an antibody dependent cell mediated cytotoxicity test (ADCC). Five patients were found to have cytotoxic antibodies against 1 to 10 meningioma cell lines. However, three of these were also cytotoxic against malignant glioma cell lines but not against other unrelated tumours. These results suggest the existence of surface antigens common to meningiomas and gliomas.
D000328:Adult; D000368:Aged; D000912:Antibodies, Neoplasm / Q000032:analysis*; D000917:Antibody Formation; D000920:Antibody-Dependent Cell Cytotoxicity; D000951:Antigens, Neoplasm / Q000276:immunology*; D001932:Brain Neoplasms / Q000276:immunology*; D002460:Cell Line; D003429:Cross Reactions; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000276:immunology*; D008579:Meningioma / Q000276:immunology*; D008875:Middle Aged
D000912:Antibodies, Neoplasm; D000951:Antigens, Neoplasm