title: Deficit of cell-mediated immunity, chromosomal alterations and defective DNA repair in a case of dyskeratosis congenita.
abstract: A case of dyskeratosis congenita with depressed responsiveness to policlonal mitogens (PHA, Con-A, PKM) and negative skin tests (PPD, SK-SD, Candidin, Trichophytin) is reported. Chromatid breaks and reduction of the capacity of DNA repair were also present. The findings are discussed in relationship to the prognosis of dyskeratosis congenita.
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000150:complications*; D025063:Chromosome Disorders; D004260:DNA Repair; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000209:etiology; D007111:Immunity, Cellular; D007136:Immunoglobulins / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D012871:Skin Diseases / Q000276:immunology*; D014466:Ultraviolet Rays
chemical_list: D007136:Immunoglobulins