[Sensitivity of different lines of mice to the carcinogenic action of 1,2-dimethylhydrazine].
Female mice of lines TBA, C57BL/6, BALB/c, and hydrids F1 (CBAxC57BL/6) were given 1,2-dimethylhydrazine (DMH) in a dose of 16 mg/kg 20 times weekly. Mice of line BALB/c proved to be mostly sensitive to a carcinogenic effect of DMH (the most low survival rate, the appearance of tumors in the anal region 5 weeks earlier, and much greater probability of their occurrence compared with other lines, extensive tumor invasion of the large intestine). The most low sensitivity to a carcinogenic action of DMH was noted in mice of line C57BL/6. It was found possible to induce uterine sarcomas by DMH in hybrids F1 (CBAxC57BI/6) in a comparatively high per cent of cases (15.4%). Morphological changes in the liver were noted in DMH exposed mice of all lines (dystrophy, cystic cavities, the outgrowth of bile ducts and the connective tissue), which were mostly pronounced in mice of line C57BL/6 (in one case it was adenocarcinoma). The genetic factor is suggested to be of certain importance in the sensitivity to DMH carcinogenic effect.
D000818:Animals; D001653:Bile Ducts, Intrahepatic / Q000187:drug effects; D004127:Dimethylhydrazines / Q000633:toxicity*; D005260:Female; D006824:Hybridization, Genetic / Q000187:drug effects; D008763:Methylhydrazines / Q000633:toxicity*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains / Q000235:genetics; D009374:Neoplasms, Experimental / Q000139:chemically induced*
D004127:Dimethylhydrazines; D008763:Methylhydrazines
O chuvstvitel'nosti mysheĭ razlichnykh liniĭ k kantserogennomu deĭstviiu 1,2-dimetilgidrazina.