title: Nosiheptide, a sulfur-containing peptide antibiotic isolated from Streptomyces actuosus 40037.
abstract: Nosiheptide (9671 R.P.) isolated from Streptomyces actuosus 40037 (NRRL 2954) is a sulfur-containing polypeptidic antibiotic, quite different from all the other members of this family. Very active in vitro against gram-positive bacteria, it is inactive in vivo in experimentally infected mice. Not toxic, even at high dose, it may be used as a feed additive for chickens and pigs and it shows a favourable effect on the growth and conversion index.
mesh_terms: D000821:Animal Feed; D000818:Animals; D000900:Anti-Bacterial Agents; D001419:Bacteria / Q000187:drug effects; D002645:Chickens; D004353:Drug Evaluation, Preclinical; D005503:Food Additives; D013050:Spectrometry, Fluorescence; D013055:Spectrophotometry, Infrared; D013302:Streptomyces / Q000032:analysis*; D013552:Swine; D013844:Thiazoles / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D005503:Food Additives; D013844:Thiazoles; C014134:nosiheptide