Trimethoprim enhances the antibacterial activity of nalidixic and oxolinic acids and delays the emergence of resistance.
Trimethoprim enhances the in vitro activity of nalidixic and oxolinic acids against some representative pathogenic microorganisms, including those which are most frequently responsible for urinary tract infections, and delays the emergence of resistance in many of them.
D001419:Bacteria / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D004357:Drug Synergism; D009268:Nalidixic Acid / Q000494:pharmacology*; D010093:Oxolinic Acid / Q000494:pharmacology*; D013045:Species Specificity; D014295:Trimethoprim / Q000494:pharmacology*
D009268:Nalidixic Acid; D014295:Trimethoprim; D010093:Oxolinic Acid