Lactogenesis induced by prostaglandin F2 alpha in pregnant rabbits.
PGF2 alpha may have a primarily luteolytic action and hence diminish Pg secretion. This triggers the release of PRL and other hormones of the lactogenic complex with the consequent production of milk substances in the mammary gland. Later, when the uterine tissue is depleted of Pg, pregnancy is terminated.
D000818:Animals; D002364:Caseins / Q000096:biosynthesis; D005260:Female; D007774:Lactation / Q000187:drug effects*; D007785:Lactose / Q000096:biosynthesis; D008186:Luteolytic Agents; D008321:Mammary Glands, Animal / Q000378:metabolism; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011388:Prolactin / Q000097:blood; D011460:Prostaglandins F / Q000494:pharmacology*; D011817:Rabbits
D002364:Caseins; D008186:Luteolytic Agents; D011460:Prostaglandins F; D011374:Progesterone; D011388:Prolactin; D007785:Lactose