title: Serum somatomedin activity measured as sulphation factor in peripheral, hepatic and renal veins of mongrel dogs: basal levels.
abstract: Serum somatomedin (SM) activity measured as sulphation factor on chick embryo cartilage was determined in peripheral (PV), hepatic (HV) and renal (RV) veins or 36 mongrel dogs. Mean SM activity +/- SEM was 0.53 +/- 0.03 U/ml in peripheral and hepatic veins, and 0.61 +/- 0.04 U/ml in renal vein (P less than 0.005). When the gradient of SM activity in hepatic or renal vein to that in peripheral vein, [HV]-[PV] or [HV]-[PV], was plotted versus SM activity in peripheral blood [PV], a negative correlation was found in the case of hepatic but not of renal blood. These data indicate that the kidney may be a production site of SM activity, whereas the liver is differently implicated in the overall regulation of SM activity.
mesh_terms: D000818:Animals; D001681:Biological Assay; D001769:Blood; D002642:Chick Embryo; D004285:Dogs; D006503:Hepatic Veins; D007668:Kidney / Q000502:physiology; D008099:Liver / Q000502:physiology; D008297:Male; D012082:Renal Veins; D013002:Somatomedins / Q000096:biosynthesis / Q000097:blood*
chemical_list: D013002:Somatomedins