Effect of K and Mg salts of aspartic acid on haemopoiesis and recovery from radiation damage in mice.
Male mice of a non-inbred strain "H" were used to verify the effect of a 10-day peroral administration of K and Mg aspartates on haemopoietic functions. The salts were proved to stimulate the proliferation and differentiation processes in the thymus, bone marrow and spleen tissues. Mice exposed to a single whole-body X-irradiation after pretreatment with K, Mg aspartate exhibited a more conspicuous postirradiation regeneration of haemopoietic organs and an increased postirradiation survival. The results suggest the possibility of using K, Mg aspartate for radioprotective purposes.
D000818:Animals; D001224:Aspartic Acid / Q000031:analogs & derivatives*; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism; D003114:Colony-Forming Units Assay; D004920:Erythropoiesis / Q000187:drug effects; D006410:Hematopoiesis / Q000187:drug effects*; D008297:Male; D051379:Mice; D009929:Organ Size; D011195:Potassium Magnesium Aspartate / Q000494:pharmacology* / Q000627:therapeutic use; D011833:Radiation Injuries, Experimental / Q000188:drug therapy*; D011837:Radiation-Protective Agents / Q000627:therapeutic use; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism
D011837:Radiation-Protective Agents; D001224:Aspartic Acid; D011195:Potassium Magnesium Aspartate