title: Blood plasma binding of acebutolol and diacetolol in man.
abstract: 1 Acebutolol or diacetolol were added to fresh human plasma in varying concentrations and their extent of binding at 25 degrees C measureed by an equilibrium dialysis technique. 2 The extent of binding for both compounds was shown to be very low, being 11-19% for acebutolol and 6-9% for diacetolol. 3 Partition coefficients were measured in an n- octanol/phosphate buffer (0.05M, pH 7.4) solvent system. For a cebutolol, P = 0.62 and for diacetol, P = 0.08. 4 The very low plasma binding is in accord with the hydrophilic partition coefficients of these compounds.
mesh_terms: D000070:Acebutolol / Q000031:analogs & derivatives* / Q000097:blood*; D001798:Blood Proteins / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D011485:Protein Binding; D012995:Solubility
chemical_list: D001798:Blood Proteins; C025527:diacetolol; D000070:Acebutolol