Intravascular haemolysis and renal failure caused by intermittent rifampicin treatment.
Rifampicin is a widely used anti-tuberculous drug. Administered daily, only minimal side-effects occur. With intermittent therapy and, as happened in the present case, when the drug is administered after an interruption of treatment, severe adverse reactions [5] (thrombocytopenia, renal failure, and haemolysis) may occur.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000368:Aged; D000743:Anemia, Hemolytic / Q000139:chemically induced*; D000906:Antibodies; D004334:Drug Administration Schedule; D006801:Humans; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008297:Male; D012293:Rifampin / Q000008:administration & dosage / Q000009:adverse effects*; D013997:Time Factors
D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D012293:Rifampin