Suppression of prolactin and gonadotropin secretion in post-menopausal women by 2-hydroxyestrone.
An infusion of 2-hydroxyestrone given to estrogen primed post-menopausal women resulted in a rapid and total suppression of serum prolactin. Serum LH responded with an initial rise followed by a 30% decrease below baseline values. Serum FSH exhibited a significant suppression below preinfusion levels. The catechol estrogen had no effect on serum LH, FSH and PRL in post-menopausal women who were not pretreated with estrogens. This impact of 2-hydroxyestrone on pituitary hormone secretion provides for the physiological role of this non-uterotropic estrogen in the neuroendocrine mechanisms of the human.
D004970:Estrone / Q000031:analogs & derivatives*; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D006894:Hydroxyestrones; D007700:Kinetics; D007986:Luteinizing Hormone / Q000097:blood*; D008593:Menopause; D008875:Middle Aged; D011388:Prolactin / Q000097:blood*
D006894:Hydroxyestrones; D004970:Estrone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone