Neomycin and the combination of neomycin and bacitracin in the prevention of bacterial infection in surgery of the colon and/or rectum.
In two groups of patients submitted to surgery of the colon and/or rectum, treatment to prevent bacterial infections using a combination of 100 mg neomycin and 10,000 U bacitracin every 6 h for 48 h gave the same results as neomycin employed alone at a dosage of 500 mg every 6 h for 48 h. Results confirm the synergism of action between neomycin and bacitracin.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001414:Bacitracin / Q000008:administration & dosage*; D001419:Bacteria / Q000302:isolation & purification; D003106:Colon / Q000601:surgery*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D012007:Rectum / Q000601:surgery*; D012737:Sex Factors; D013530:Surgical Wound Infection / Q000517:prevention & control*; D013997:Time Factors
D001414:Bacitracin; D009355:Neomycin