[Autoradiographic distribution of 14C after administering tracer-marked nitroprusside, cyanide and thiocyanate to pregnant mice and rats (author's transl)].
Doses of ca. 2--3 mg/kg of nitroprusside, cyanide and thiocyanate, tracer-marked with 14C, were applied i.v. to pregnant mice and rats. Autoradiograms of the whole animal were taken 1 min, 10 min and 60 min after administration. After administering nitroprusside two phases of the tracer pattern could be distinguished: the phase of removal of the cyanide poisoning with tracer-markings predominant in the liver and the lungs, followed by the phase of thiocyanate excretion, with tracer-markings predominantly in the stomach and urinary system. Tracer-markings in the foetuses were observed during the thiocyanate phase, but not during the cyanide phase. The therapeutic consequences are discussed.
D000818:Animals; D001345:Autoradiography; D003486:Cyanides / Q000378:metabolism*; D005260:Female; D005292:Ferricyanides / Q000378:metabolism*; D051379:Mice; D009599:Nitroprusside / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D013861:Thiocyanates / Q000378:metabolism*; D014018:Tissue Distribution
D003486:Cyanides; D005292:Ferricyanides; D013861:Thiocyanates; D009599:Nitroprusside
Autoradiographische Verteilung von 14C nach intravenöser Gabe von 14C-markiertem Nitroprussidnatrium, Cyanid und Thiocyanat bei trächtigen Mäusen und Ratten.