[Myocardial metabolism after one hour of anoxia and deep generalised hypothermia. Experimental study in the dog (author's transl)].
Fifteen young dogs weighing less than six kilograms underwent circulatory arrest for one hour and profound hypothermia with extra-corporeal circulation. During reperfusion, myocardial metabolism was studied by comparing the oxygen arterio-venus (02 A-V) difference and lactate consumption at different temperatures. As the myocardial temperature rose, 02 A-V difference increased from 4 vl/100 cc at 25 degrees C to 10 vol/100 cc and K1 lactate balance rose from -19,3% to + 8% which indicates a large increase in lactate consumption. This study shows that profound and generalized hypothermia ensures good myocardial protection during at least one hour of ischemia. This experimental study confirms results obtained with other forms of cardiac hypothermia.
D000818:Animals; D004285:Dogs; D005112:Extracorporeal Circulation; D007036:Hypothermia, Induced; D007773:Lactates / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism*; D010100:Oxygen / Q000097:blood / Q000494:pharmacology*; D010101:Oxygen Consumption; D011773:Pyruvates / Q000378:metabolism; D013997:Time Factors
D007773:Lactates; D011773:Pyruvates; D010100:Oxygen
Métabolisme du myocarde après une heure d'anoxie et hypothermie profonde généralisée. Etude expérimentale chez le chiot.