Effect of some nitrotoluenes on the biotransformation of xenobiotics in rats.
Male rats were treated with phenobarbital, a dinitrotoluene (2,4-DNT or 2,6-DNT), or 2,4,6-trinitrotoluene (2,4,6-TNT); and the biotransformation of model xenobiotics was determined. Phenobarbital produced a stimulation, and 2,6-DNT produced a biphasic effect in biotransformation.
D000818:Animals; D001711:Biotransformation / Q000187:drug effects*; D004136:Dinitrobenzenes / Q000494:pharmacology*; D008297:Male; D009578:Nitrobenzenes / Q000494:pharmacology*; D010243:Paralysis / Q000139:chemically induced; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D014303:Trinitrotoluene / Q000494:pharmacology*
D004136:Dinitrobenzenes; D009578:Nitrobenzenes; D014303:Trinitrotoluene; C016403:2,4-dinitrotoluene; C023514:2,6-dinitrotoluene; D010634:Phenobarbital