Influence of the amount of platelet-bound IgG on platelet survival and site of sequestration in autoimmune thrombocytopenia.
Seventeen patients with idiopathic autoimmune thrombocytopenic purpura were studied in order to establish whether the amount of platelet-bound antibody influenced the rate and site at which these platelets were destroyed. Platelet-bound antibody was measured by a quantitative antiglobulin consumption technique, and platelet survival and sites of sequestration were determined by the use of 51Cr-labeled platelets and surface radioactivity measurements. A correlation significant at the 5% level was observed between the amount of platelet-bound antibody and the rate of platelet destruction. A highly significant correlation (p less than 0.001) existed between antiplatelet antibody and spleen: liver surface radioactivity ratios, demonstrating that greater amounts of antibody bound to platelets result increasingly in their destruction within the liver.
D000328:Adult; D001327:Autoimmune Diseases / Q000276:immunology*; D001665:Binding Sites; D001792:Blood Platelets / Q000276:immunology*; D002470:Cell Survival; D002860:Chromium Radioisotopes; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D008099:Liver / Q000276:immunology; D008297:Male; D013921:Thrombocytopenia / Q000276:immunology*
D002860:Chromium Radioisotopes; D007074:Immunoglobulin G