title: On the fidelity of DNA synthesis:effects of steroids and intercalating agents.
abstract: Studies on the fidelity of DNA synthesis in vitro were extended to pharmacological agents that interact non-covalently to DNA. Several steroids, intercalators and cancer chemotherapeutic agents increased the relative frequency of incorrect deoxynucleotide incorporation in the fidelity assay. The relationship between non-covalent interactions with DNA and the decreased fidelity of DNA synthesis in vitro is considered.
mesh_terms: D000596:Amino Acids / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000494:pharmacology; D002241:Carbohydrates / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D004261:DNA Replication / Q000187:drug effects; D007364:Intercalating Agents / Q000494:pharmacology*; D013256:Steroids / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D000970:Antineoplastic Agents; D002241:Carbohydrates; D007364:Intercalating Agents; D013256:Steroids; D004247:DNA