Detection of autoimmune response to rabbit epididymal and seminal spermatozoa.
Conventional and anaphylactic autoantibodies to rabbit epididymal and seminal spermatozoa were detected in sera of rabbits autoimmunized by several procedures. Antibodies against epididymal spermatozoa were found in 85% of rabbits showing lesions of varying degrees in testes. When the comparison was made with antibodies to antigens of spermatozoa from semen, the correlation was markedly lower. The data prove the importance of a proper selection of the antigenic material when looking for antibodies to spermatozoa in studies of autoimmunity and fertility.
D000818:Animals; D000941:Antigens; D001323:Autoantibodies / Q000096:biosynthesis*; D003168:Complement Fixation Tests; D004822:Epididymis / Q000276:immunology*; D004823:Epididymitis / Q000209:etiology; D007116:Immunization, Passive; D008297:Male; D011817:Rabbits; D012661:Semen / Q000276:immunology*; D013081:Sperm Motility; D013094:Spermatozoa / Q000276:immunology*; D013737:Testis / Q000473:pathology
D000941:Antigens; D001323:Autoantibodies