Food and protein intake, glucagon, and distribution of alpha-aminoisobutyrate in the rat.
Distribution of alpha-aminoisobutyric acid (AIB) in the rat was modified by food, dietary protein, and glucagon. In rats last fed 24 h before AIB injection, AIB clearance from plasma and uptake into liver were greater in rats fed a high-protein diet (60% casein) than in rats fed the control diet (18% casein); AIB clearance from plasma and uptake into muscle were lowered by a low-protein diet (6% casein). Feeding rats lowered clearance of AIB from plasma in low- and high-protein groups. Distribution ratios (AIB concentration in tissue water/AIB in plasma) were low in all tissues but liver during the first 7 h after feeding high protein when compared to the control values; ratios were low in muscle, heart, and kidney after feeding low protein. Maximum ratios occurred at different times for different tissues; the time was delayed by the high-protein diet in all tissues but liver. Glucagon increased all ratios in rats fed the control or low-protein diets, with the smallest changes occurring in liver and muscle from low-protein rats.
D000621:Aminoisobutyric Acids / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000378:metabolism; D004044:Dietary Proteins / Q000494:pharmacology*; D005247:Feeding Behavior / Q000502:physiology*; D005934:Glucagon / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D000621:Aminoisobutyric Acids; D004044:Dietary Proteins; D005934:Glucagon