[Influence of phospholipids and their combination with prothrombin complex and calcium ions on coagulation in mice and rabbits both normal and affected by acetylsalicylic acid (author's transl)].
The influence of phospholipids and their combination with prothrombin and calcium on coagulation both normal and affected by acetylsalicylic acid (ASA) was investigated by determination of the bleeding time of mice, thrombelastographic (TEG) measurements and counting of thrombocytes of rabbits. Bleeding times and times of the TEG were prolonged after oral application of ASA, while thrombus stability was not altered. The number of thrombocytes decreased. Bleeding- and TEG-times normalized after injection of phospholipids. This effect was increased and of longer duration when phospholipids were combined with calcium and prothrombin. Decrease of the number of thrombocytes caused by pretreatment with ASA normalized only after injection of phospholipids together with prothrombin and calcium. The number of thrombocytes was not negatively influenced by the therapy in animals with normal coagulation.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D002118:Calcium / Q000494:pharmacology*; D004347:Drug Interactions; D051379:Mice; D010743:Phospholipids / Q000494:pharmacology*; D011516:Prothrombin / Q000502:physiology*; D011817:Rabbits
D010743:Phospholipids; D011516:Prothrombin; D001241:Aspirin; D002118:Calcium
Der Einfluss der kombinierten Applikation von Phospholipiden, Prothrombin-Komplex und Kalziumionen auf die normale und die durch Acetylsalicylsäure gestörte Blutgerinnung bei Mäusen und Kaninchen.