title: The role of prostaglandins in the maintenance of the tone of the rabbit urinary bladder.
abstract: The effects of bladder distension on the production of prostaglandins (PGs) were studied in an isolated rabbit bladder preparation. Increasing bladder distensions induced a proportional release of PGs together with a parallel increase in endovesical pressure; pretreatment with indomethacin prevented both. Infusion of exogenous PGs into the arteries of bladders previously filled and treated with indomethacin produced a rise in endovesical pressure similar to that observed subsequent to distension of the untreated bladder. Our results suggest that PGs and particularly PGE2 play a role in the maintenance of vesical tone during distension.
mesh_terms: D000818:Animals; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D011312:Pressure; D011453:Prostaglandins / Q000096:biosynthesis* / Q000502:physiology; D011458:Prostaglandins E / Q000378:metabolism / Q000502:physiology; D011460:Prostaglandins F / Q000502:physiology; D011817:Rabbits; D001743:Urinary Bladder / Q000187:drug effects / Q000502:physiology*
chemical_list: D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D007213:Indomethacin