Angiotoxicity of oxygenated sterols and possible precursors.
Cell death, inflammation, and repair in rabbits' aortas and pulmonary arteries were observed at 3-, 7-, and 10-day periods after the intravenous injection of oxygenated sterols. Thus, oxygenated sterols, not cholesterol, may play the primary role in arterial wall injury and lesion development.
D000818:Animals; D001011:Aorta / Q000187:drug effects; D001808:Blood Vessels / Q000187:drug effects* / Q000473:pathology; D002784:Cholesterol / Q000031:analogs & derivatives* / Q000633:toxicity; D004852:Epoxy Compounds / Q000633:toxicity*; D004988:Ethers, Cyclic / Q000633:toxicity*; D005260:Female; D006888:Hydroxycholesterols / Q000633:toxicity; D007810:Lanosterol / Q000031:analogs & derivatives / Q000633:toxicity; D008297:Male; D009336:Necrosis; D010084:Oxidation-Reduction; D011651:Pulmonary Artery / Q000187:drug effects; D011817:Rabbits; D013329:Structure-Activity Relationship
D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D006888:Hydroxycholesterols; D007810:Lanosterol; D002784:Cholesterol