[Mechanism of the effect of thyroid hormones on renal function].
Chronic experiments were conducted on 32 dogs; it was shown that thyroxin (T4) administered in a dose of 50 micrograms/kg into the renal artery through the implanted catheter produced a primary action on the tubular apparatus of the kidney inducing natriuresis from the first minutes in the experimental kidney. High T4 doses (200 micrograms/kg) activated renal hemodynamics as well. Natriuretic effect of T4 was not eliminated by alpha- and beta-adrenoblocker. Triiodthyronine (T3) manifested a direct action on the vascular apparatus of the kidney from the first minutes. Its activating effect on hemodynamics (in the same way as that of T4) is eliminated or diminished by beta-adrenoblockers.
D000818:Animals; D001775:Blood Circulation / Q000187:drug effects; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006728:Hormones / Q000494:pharmacology; D007668:Kidney / Q000098:blood supply / Q000502:physiology*; D013974:Thyroxine / Q000494:pharmacology*; D014284:Triiodothyronine / Q000494:pharmacology*
D006728:Hormones; D014284:Triiodothyronine; D013974:Thyroxine
O mekhanizme deĭstviia tireoidnykh gormonov na funktsiiu pochki.