The role of T-agglutinin in the disappearance of erythrocytes artificially aged by desialylation.
The chance discovery of two mouse strains, one with and one without a high presence of serum T-agglutinin, permitted the investigation of the role of this antibody in the disappearance of desialylated erythrocytes, which may be regarded as a model for ageing. The proportional relationship between the quantity of sialic acid removed and the diminution of half-life is not affected by the presence or absence of T-agglutinin. Opsonization by T-agglutinin would therefore appear to be an improbable mechanism. Other possible theories are discussed.
D000373:Agglutinins / Q000502:physiology*; D000818:Animals; D002457:Cell Extracts; D004905:Erythrocyte Aging; D005260:Female; D006207:Half-Life; D006388:Hemagglutinins / Q000502:physiology*; D007075:Immunoglobulin M / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D012794:Sialic Acids / Q000097:blood / Q000502:physiology*
D000373:Agglutinins; D002457:Cell Extracts; D006388:Hemagglutinins; D007075:Immunoglobulin M; D012794:Sialic Acids; C023994:T-agglutinin