[The interaction of cellular immunity and of viral factors in the pathogenesis and the resolution of HB virus infections in hemodialysis (author's transl)].
A study of delayed cutaneous hypersensitivity (DC) was carried out in 50 chronic hemodialysis patients divided into 3 groups according to their serological response to the HB virus (HBV): 31 chronic carriers of Ag HBs (13 HBe positive and 18 HBe negative and 19 having eliminated Ag HBs, antiHbs positive). The results of DCH testing were compared in relation to the 3 patient groups. The number and sum of indurations were reduced, this being more marked in the women, in all the uraemic patients tested. Male hemodialysis patients who were carriers of Ag HBe had the weakest responses, significantly more depressed than those of the HBe positive HBe negative or anti-HBs carrier patients. The presence of Ag HBe was correlated with persistently raised transaminases. In chronic carriers of Ag HBe, hepatic cytolysis was always absent when DCH reactions were negative, and was seen only in the presence of a cellular immune reaction. These results suggest the interaction, in the hemodialysis patient, of virological factors related to Ag HBe and cell mediated immunological factors in the pathogenesis of hepatic lesions related to HBV.
D000328:Adult; D002462:Cell Membrane / Q000276:immunology; D004231:Diuresis; D005260:Female; D006509:Hepatitis B / Q000209:etiology / Q000276:immunology*; D006511:Hepatitis B Antigens / Q000032:analysis; D006515:Hepatitis B virus / Q000276:immunology*; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis; D007111:Immunity, Cellular; D008099:Liver / Q000473:pathology; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D012737:Sex Factors; D012882:Skin Tests
D006511:Hepatitis B Antigens
Pathogénie et résolution des infections à virus HB de l'hémodialysé. Interaction de l'immunité cellulaire et des facteurs viraux.