Inhibition of candidacidal activity of human neutrophil leukocytes by aminoglycoside antibiotics.
We have tested the effect of five aminoglycoside antibiotics (gentamicin, sisomicin, tobramycin, ribostamycin, and amikacin) on the candidacidal activity of human neutrophils in vitro; all of them are inhibitory and can be grouped into three significantly different levels of toxicity. Gentamicin in the most toxic and sisomicin is the least toxic.
D000583:Amikacin / Q000494:pharmacology; D000617:Aminoglycosides / Q000009:adverse effects / Q000494:pharmacology*; D002175:Candida / Q000276:immunology*; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D012271:Ribostamycin / Q000494:pharmacology; D012853:Sisomicin / Q000494:pharmacology; D014031:Tobramycin / Q000494:pharmacology
D000617:Aminoglycosides; D005839:Gentamicins; D012271:Ribostamycin; D000583:Amikacin; D014031:Tobramycin; D012853:Sisomicin