Susceptibility and resistance of Sprague--Dawley and spontaneously hypertensive rats to aortic calcification induced by a diet high in CaPO4.
Male and female, Sprague--Dawley (S--D) and spontaneously hypertensive rats (SHR) with arteriosclerosis (breeders) and without arteriosclerosis (virgins) were fed a regular control diet or a diet high in CaPO4. After 45 days on the high Ca : P diet, there were no obvious adverse effects on the health, body, or organ weights of any animals. Although the high Ca : P diet did not cause any exacerbation of the spontaneous high blood pressure of SHR, it did cause hyperlipidemia and abnormally elevated corticosterone levels, but paradoxically, low normal levels of circulating Ca and P. Despite the fact that the high Ca : P diet produces kidney stones, there was no increase in the incidence of kidney stones which appear spontaneously in breeder rats. The high Ca : P diet did not alter the intimal hyalin lesions of the gonadal arterioles which appear spontaneously and exclusively in SHR breeders but it did produce severe exacarbation of the aortic calcification which appears spontaneously in repeatedly bred, S--D rats.
D000818:Animals; D001012:Aorta, Abdominal / Q000473:pathology; D001013:Aorta, Thoracic / Q000473:pathology*; D001161:Arteriosclerosis / Q000235:genetics; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects; D001806:Blood Urea Nitrogen; D001835:Body Weight; D002130:Calcium Phosphates / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000494:pharmacology*; D003345:Corticosterone / Q000097:blood; D005260:Female; D006943:Hyperglycemia / Q000235:genetics; D006973:Hypertension / Q000235:genetics; D007668:Kidney / Q000378:metabolism / Q000473:pathology*; D008055:Lipids / Q000097:blood; D008297:Male; D009929:Organ Size; D051381:Rats / Q000235:genetics*
D001786:Blood Glucose; D002130:Calcium Phosphates; D002136:Calcium, Dietary; D008055:Lipids; D003345:Corticosterone