[Energy metabolism and myocardial contractile activity in cardiocytotoxic injury].
It was established in experiments on anesthetized dogs with a closed thorax that injection of anticardiac cytotoxix serum into one of the main branches of the left coronary artery is accompanied by regional disturbances of energy metabolism, manifested by a decrease in ATP, ADP, AMP and glycogen content, and in the contractility of a injured area of the left ventricle. Undamaged myocardium of the left and right ventricles showed a compensatory hyperfunction and an increased level of noradrenaline. The energy metabolism parameters of undamaged cardiac area do not undergo any material changes.
D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D004285:Dogs; D004734:Energy Metabolism / Q000187:drug effects*; D006352:Heart Ventricles / Q000187:drug effects; D007106:Immune Sera / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000276:immunology*
D007106:Immune Sera
Energeticheskoe obmen i sokratitel'naia aktivnost' miokarda pri kardiotsitotoksicheskom povrezhdenii.