Effects of rat adrenal homogenate on induction of atherosclerosis in cholesterol-fed rabbits.
Virgin male Sprague-Dawley rats are resistant to atheroma formation. An adrenal homogenate from such rats delayed the increase in serum cholesterol concentrations in cholesterol-fed New Zealand white rabbits. More importantly, aortic atherosclerosis was markedly reduced when compared to a similar population fed cholesterol without adrenal homogenate for 14 weeks. The nature of the active constituent in this homogenate and its mode of action are unknown.
D000302:Adrenal Cortex / Q000502:physiology*; D000818:Animals; D001011:Aorta / Q000473:pathology*; D001161:Arteriosclerosis / Q000139:chemically induced* / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004036:Diet, Atherogenic; D008297:Male; D011817:Rabbits; D051381:Rats
D002791:Cholesterol, Dietary; D002784:Cholesterol