title: Induction and inhibition of bone matrix resorption.
abstract: A method is described by which the action of hormones on cartilage and bone matrix in mice is ascertained by measuring 35S release from bone explants. Parathyroid extract was found to increase the rate of 35S release in vitro as well as in samples from pretreated animals, whereas calcitonin and 25-hydroxycholecalciferol were effective only in vitro.
mesh_terms: D000818:Animals; D001857:Bone Matrix / Q000378:metabolism*; D001862:Bone Resorption / Q000187:drug effects*; D002116:Calcitonin / Q000494:pharmacology; D002356:Cartilage / Q000378:metabolism; D006887:Hydroxycholecalciferols / Q000494:pharmacology; D066298:In Vitro Techniques; D051379:Mice; D010281:Parathyroid Hormone / Q000494:pharmacology; D011239:Prednisolone / Q000494:pharmacology; D013462:Sulfur Radioisotopes
chemical_list: D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D013462:Sulfur Radioisotopes; D002116:Calcitonin; D011239:Prednisolone