Immunotherapy of autochthomous rat methylcholanthrene-induced sarcomas with a mixture of allogeneic tumor cells and BCG-CWS.
Experimental immunotherapy with a mixture of allogeneic tumor cells and BCG cell-wall skeleton (BCG-CWS) was carried out against established autochthonous fibrosarcomas induced by 3-methylcholanthrene (MCA) in the subcutaneous tissue of rats. The inhibitory effect on growth in the early stage, tumor-size up to 2 cm in diameter, was significantly observed. No significant difference, however, was shown as compared with the effect of treatment with allogeneic tumor cells alone. That is to say, a more effective inhibition of growth due to the addition of BCG-CWS was not demonstrated.
D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use*; D002473:Cell Wall / Q000276:immunology; D005354:Fibrosarcoma / Q000628:therapy; D007114:Immunization; D007167:Immunotherapy / Q000379:methods*; D008297:Male; D008748:Methylcholanthrene; D009368:Neoplasm Transplantation; D051381:Rats; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000628:therapy*; D013997:Time Factors; D014184:Transplantation, Homologous
D001500:BCG Vaccine; D008748:Methylcholanthrene