title: Synthesis and biological activity of some 15-oxaestranes.
abstract: The estrogenic activity of orally administered 15-oxaestrone was evaluated by the uterotropic assay in rats and was found to be 12 times greater than that of estrone. In addition, several analogues of 15-oxaestrone were prepared and their estrogenic potency was determined.
mesh_terms: D000818:Animals; D045166:Estradiol Congeners / Q000138:chemical synthesis*; D004962:Estranes / Q000138:chemical synthesis* / Q000494:pharmacology; D005260:Female; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013329:Structure-Activity Relationship; D014599:Uterus / Q000187:drug effects
chemical_list: D045166:Estradiol Congeners; D004962:Estranes