Effect of serotonin on Y-maze retention and hippocampal protein synthesis in rats.
The effect of serotonin (5-HT) on consolidation of a brightness discrimination reaction was investigated in rats. Five microgram 5-HT, injected intrahippocampally immediately after training, impaired retention of the brightness discrimination tested 24 hr later. In biochemical experiments, leucine incorporation into hippocampal proteins in vivo was 32% inhibited by 5 microgram 5-HT. Leucine incorporation into proteins of hippocampal slices in vitro was decreased by 5 x 10(-5)M 5-HT. The results seem to support Essman's assumption that inhibition of brain protein synthesis by 5-HT may be responsible for the memory impairment. But also some other possibilities for a mechanism of 5-HT amnesia must be discussed.
D000818:Animals; D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism*; D007858:Learning / Q000187:drug effects*; D007930:Leucine / Q000378:metabolism; D008297:Male; D008568:Memory / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D011287:Prejudice / Q000187:drug effects; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*
D009419:Nerve Tissue Proteins; D012701:Serotonin; D007930:Leucine