24-hour rhythm of human plasma noradrenaline and the effect of fusaric acid, a dopamine-beta-hydroxylase inhibitor.
A 24-hour of basal noradrenaline (NA) levels in normal human plasma in the supine position was observed; higher NA levels during daytime and lower NA levels at night, especially early in the morning. This pattern of the 24-hour rhythm of plasma NA levels was similar to that of serum dopamine-beta-hydroxylase (DBH) levels. After oral administration of fusaric acid, a DBH inhibitor, the rhythm changed, and plasma NA levels increased at 3 h and returned to the initial level at 23 h. In contrast, plasma DBH activity was markedly inhibited during 23 h after fusaric acid administration.
D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects*; D004299:Dopamine beta-Hydroxylase / Q000037:antagonists & inhibitors / Q000097:blood*; D005260:Female; D005669:Fusaric Acid / Q000494:pharmacology*; D006801:Humans; D009638:Norepinephrine / Q000097:blood*; D010848:Picolinic Acids / Q000494:pharmacology*; D013997:Time Factors
D010848:Picolinic Acids; D004299:Dopamine beta-Hydroxylase; D005669:Fusaric Acid; D009638:Norepinephrine