The complement system in hemolytic-uremic syndrome in childhood.
A dynamic estimation of the complement system was obtained by immunochemical estimation of C3, C4, C5, C1q, C3b + C3c, C3d, Ba in children with hemolytic-uremic syndrome. The presence of increased breakdown products of C3 (C3b + C3c, C3d) and of factor B (Ba) suggests an activation of the complement system possibly by the alternative pathway. No definite explanation for these complement abnormalities can be given.
D002648:Child; D003172:Complement C1 / Q000276:immunology; D003176:Complement C3 / Q000276:immunology; D003179:Complement C3b / Q000276:immunology; D003181:Complement C4 / Q000276:immunology; D003182:Complement C5 / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology*; D006463:Hemolytic-Uremic Syndrome / Q000276:immunology*; D006801:Humans
D003172:Complement C1; D003176:Complement C3; D003181:Complement C4; D003182:Complement C5; D003179:Complement C3b; D003165:Complement System Proteins