Burn wound sepsis: effect of delayed treatment with topical chemotherapy on survival.
Using a standardized laboratory rat model of burn wound sepsis, a regimen of once a day application of Silvadene has been found to be more effective treatment than Sulfamylon or cerium-Silvadene. Delaying treatment following infection resulted in decreased survival. Possible reasons for difference in mortality are once-daily application, or perhaps a change in sensitivity between drugs and the infective organism (Ps. aeruginosa) over time.
D000287:Administration, Topical; D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000401:mortality; D002563:Cerium / Q000008:administration & dosage / Q000627:therapeutic use; D004195:Disease Models, Animal; D008272:Mafenide / Q000627:therapeutic use; D011552:Pseudomonas Infections / Q000188:drug therapy / Q000401:mortality; D051381:Rats; D012837:Silver Sulfadiazine / Q000008:administration & dosage / Q000627:therapeutic use*; D013411:Sulfadiazine / Q000627:therapeutic use*; D013997:Time Factors; D014946:Wound Infection / Q000188:drug therapy* / Q000401:mortality
D013411:Sulfadiazine; D002563:Cerium; D008272:Mafenide; D012837:Silver Sulfadiazine