Mice tolerant to nitrous oxide are also tolerant to alcohol.
Mice exposed to 50% nitrous oxide for 3 weeks become tolerant to nitrous oxide. The nitrous oxide-tolerant animals are also tolerant to ethanol, as measured by a 40% decrease in ethanol-induced sleep times and 15% higher blood alcohol levels upon awakening compared to control mice raised in air. These results suggest a common mechanism for the development of tolerance to both alcohol and nitrous oxide.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004361:Drug Tolerance; D000431:Ethanol / Q000097:blood / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009609:Nitrous Oxide / Q000494:pharmacology*; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D000431:Ethanol; D009609:Nitrous Oxide