Inhibition by idrocilamide of the disposition of caffeine.
The pharmacokinetics of caffeine are greatly altered by concomitant administration of idrocilamide. In four healthy volunteers id rocilamide inhibited the biotransformation of caffeine and increased its half-life nine times. The untoward neuropsychiatric effects of idrocilamide are the consequence of abnormal accumulation of caffeine in regular consumers of caffeine-containing foods and beverages.
D000328:Adult; D001711:Biotransformation; D002110:Caffeine / Q000378:metabolism*; D004347:Drug Interactions; D004983:Ethanolamines / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D013997:Time Factors; D014970:Xanthines / Q000652:urine
D004983:Ethanolamines; D009125:Muscle Relaxants, Central; D014970:Xanthines; D002110:Caffeine; C004560:idrocilamide