Potent bile salt and organic anion inhibition of methotrexate uptake and accumulation in the freshly isolated rat hepatocyte.
D000227:Adenine Nucleotides / Q000494:pharmacology; D000818:Animals; D000838:Anions / Q000494:pharmacology*; D001647:Bile Acids and Salts / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D002478:Cells, Cultured; D003864:Depression, Chemical; D007700:Kinetics; D008099:Liver / Q000378:metabolism*; D008297:Male; D008727:Methotrexate / Q000378:metabolism*; D051381:Rats; D012395:Rose Bengal / Q000494:pharmacology; D013448:Sulfobromophthalein / Q000494:pharmacology
D000227:Adenine Nucleotides; D000838:Anions; D001647:Bile Acids and Salts; D013448:Sulfobromophthalein; D012395:Rose Bengal; D008727:Methotrexate