Repeated staphylococcal pyoderma in two siblings with defective neutrophil bacterial killing.
2 children with undue susceptibility to skin infections and isolated defective neutrophil bacterial killing are described. Since the NBT-reducing capabilities of granulocytes were normal, a mild form of chronic granulomatous disease was excluded. Ascorbic acid was effective in delaying and eventually suppressing infectious episodes.
D001205:Ascorbic Acid / Q000627:therapeutic use; D001770:Blood Bactericidal Activity; D002634:Chemotaxis, Leukocyte; D002648:Child; D005260:Female; D006105:Granulomatous Disease, Chronic / Q000151:congenital; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009504:Neutrophils / Q000276:immunology* / Q000502:physiology; D011711:Pyoderma / Q000188:drug therapy / Q000235:genetics*; D012008:Recurrence; D013203:Staphylococcal Infections / Q000235:genetics*
D001205:Ascorbic Acid