Therapeutic efficacy of oral oxamniquine in the toxemic form of schistosomiasis mansoni: treatment of eleven individuals from two families, and experimental study.
Two families, comprising 11 individuals in the toxemic form of schistosomiasis mansoni, infected in Belo Horizonte, Brazil were treated. Parasitological cure was obtained in 5 (45%) of the patients after a single oral dose of oxamniquine (Mansil), 20 mg/kg body weight. No significant side effects were observed. To evaluate the possibility of resistance to the drug, cercariae collected from Biomphalaria glabrata infected with micracidia from eggs obtained from three of the individuals not cured were studied. Mice infected with these three strains were cured after a single dose of examniquine. It is suggested that research be continued with other therapeutic schedules and perhaps other, more potent, drugs.
D000293:Adolescent; D000818:Animals; D001938:Brazil; D002648:Child; D005243:Feces / Q000469:parasitology; D005260:Female; D006801:Humans; D008099:Liver / Q000469:parasitology; D008297:Male; D009600:Nitroquinolines / Q000627:therapeutic use*; D010073:Oxamniquine / Q000627:therapeutic use*; D010270:Parasite Egg Count; D012550:Schistosoma mansoni; D012552:Schistosomiasis / Q000188:drug therapy* / Q000235:genetics; D014115:Toxemia / Q000188:drug therapy*
D009600:Nitroquinolines; D010073:Oxamniquine