title: Abnormalities in water homeostasis in small cell anaplastic lung cancer.
abstract: Forty-one patients with newly diagnosed small cell anaplastic lung cancer were evaluated for abnormalities in water homeostasis. Each patient underwent a standard water load (SWL) test. Overall, 68% had abnormalities in the SWL test. Abnormalities were found in 47% of the patients with carcinoma clinically limited to one hemithorax and in 86% of the patients with more extensive carcinoma. The determination of urinary antidiuretic hormone levels was available for 27 patients. Abnormally elevated levels were found in 44% of those patients. Forty-six patients had clinically detectable syndrome of the inappropriate secretion of antidiuretic hormone (SIADH); in 12% of patients water restriction was necessary. The incidence of detectable abnormalities in water homeostasis in this study was higher than has been previously recognized. The SWL test is a sensitive and useful means of determining the presence of impaired water handling in patients with small cell carcinoma of the lung.
mesh_terms: D001806:Blood Urea Nitrogen; D002277:Carcinoma / Q000150:complications / Q000378:metabolism* / Q000652:urine; D002283:Carcinoma, Bronchogenic / Q000378:metabolism; D004359:Drug Therapy, Combination; D005260:Female; D006706:Homeostasis; D006801:Humans; D007177:Inappropriate ADH Syndrome / Q000150:complications / Q000652:urine; D008175:Lung Neoplasms / Q000150:complications / Q000378:metabolism* / Q000652:urine; D008297:Male; D008722:Methods; D014667:Vasopressins / Q000652:urine; D014867:Water / Q000378:metabolism*; D014882:Water-Electrolyte Balance
chemical_list: D014867:Water; D014667:Vasopressins