Gene affecting superoxide dismutase activity linked to the histocompatibility complex in H-2 congenic mice.
The activity of cyanide-sensitive, Cu-Zn superoxide dismutase (SOD) was studied in liver sytosols from H-2 congenic strains of mice. Higher SOD activity was found in livers of mice having H-2b/A.BY, B10, and C3H.SW/haplotypes than in those of H-2a, H-2k and H-2d haplotypes. Segregation studies supported these correlations. In H-2 recombinant strains of mice, the genes influencing the liver SOD activity occur, as ascertained by mapping techniques, at or near the H-2d region of the major histocompatibility complex.
D000818:Animals; D005075:Biological Evolution; D005796:Genes; D005809:Genes, Regulator; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics*; D008099:Liver / Q000201:enzymology; D008285:Major Histocompatibility Complex; D051379:Mice; D013482:Superoxide Dismutase / Q000235:genetics*
D006183:H-2 Antigens; D013482:Superoxide Dismutase