Failure of chlorothiazide to improve urinary concentrating capacity in lithium-treated patients.
Seven patients on long-term lithium treatment were given chlorothiazide for three days. The urinary concentrating capacity did not change during the study, but serum potassium decreased significantly. Thus, chlorothiazide does not seem to produce an effect on a moderately decreased concentrating capacity during long-term lithium treatment.
D002740:Chlorothiazide / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D007671:Kidney Concentrating Ability / Q000187:drug effects*; D008094:Lithium / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D008875:Middle Aged; D011188:Potassium / Q000097:blood
D002740:Chlorothiazide; D008094:Lithium; D011188:Potassium