title: [Change in RNase activity in rat liver cells in cycloheximide protein synthesis inhibition].
abstract: Administration of cycloheximide to rats does not change the activity of acid and alkaline RNAases in the cytoplasm of hepatocytes. At the same time cycloheximide-induced inhibition of protein synthesis leads to a fall in the activity of RNAase of microsomes and membrane-bound polyribosomes. The activity of RNAase of free polyribosomes of hepatocytes rises considerably under the action of cycloheximide.
mesh_terms: D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology*; D003593:Cytoplasm / Q000201:enzymology; D003609:Dactinomycin / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005609:Free Radicals; D008099:Liver / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology; D011506:Proteins / Q000037:antagonists & inhibitors*; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism*; D012270:Ribosomes / Q000201:enzymology
chemical_list: D005609:Free Radicals; D011506:Proteins; D003609:Dactinomycin; D003513:Cycloheximide; D012260:Ribonucleases
vernacular_title: Izmenenie aktivnosti RNK-az v kletkakh pechenie krys pri ingibirovanii belkovogo sinteza tsiklogeksimidom.