A possible activation of cholesterol 7-hydroxylation by S-methylmethionine (vitamin U).
The conversion rate from 14 C-cholesterol to its 7 alpha-hydroxylated metabolites was studied in the microsome system prepared from mice liver with the pretreatment of S-methylmethionine (MMSC). In results, the increased amounts of 7 alpha-hydroxylated metabolites by MMSC show a possible activation of cholesterol 7 alpha-hydroxylase.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D006900:Hydroxylation; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D014814:Vitamin U / Q000494:pharmacology*; D014815:Vitamins / Q000494:pharmacology*
D014815:Vitamins; D014814:Vitamin U; D002784:Cholesterol