Detection of a fibroblast proliferation inhibitory factor from Capnocytophaga sputigena.
The addition of a sonic extract of Capnocytophaga sputigena to the culture fluid to human fibroblasts resulted in an inhibition of cell proliferation. The inhibition was dose-related (200 micrograms/ml caused a 90% inhibition, and 1,000 micrograms/ml caused a complete cessation of growth). The growth inhibition was not due to alterations in culture medium, pH or ionic strength, or to the effects of the C. sputigena lipopolysaccharide.
D002455:Cell Division; D002478:Cells, Cultured; D041964:Cytophagaceae / Q000276:immunology*; D005347:Fibroblasts / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D008297:Male; D010413:Penis; D010510:Periodontal Diseases / Q000382:microbiology