Mucin-producing adenocarcinomas and nonbacterial thrombotic endocarditis: pathogenetic role of tumor mucin.
The clinicopathologic data of 5 patients who died of nonbacterial thrombotic endocarditis (NBTE) and disseminated thrombosis and multiple infarcts associated with mucin-producing adenocarcinomas were presented. Histochemical studies on the valvular vegetations and thrombi revealed that histochemically stainable mucinous substance was an integral part. In 1 patient, circulating mucinous substance was found prior to the development of NBTE and disseminated thrombosis, and the identical mucinous substance was found in the tumor tissue, indicating a possible pathogenetic role of tumor mucin in NBTE-associated mucin-producing adenocarcinomas. Our observations and reports of others suggest that intravascular mucin may be responsible for the clinical syndromes of mucinous malignancies, venous thrombosis, and NBTE with emboli.
D000230:Adenocarcinoma / Q000150:complications* / Q000378:metabolism; D001021:Aortic Valve / Q000473:pathology; D001853:Bone Marrow / Q000378:metabolism; D004696:Endocarditis / Q000150:complications / Q000209:etiology* / Q000473:pathology; D006651:Histocytochemistry; D006801:Humans; D008113:Liver Neoplasms / Q000150:complications* / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000378:metabolism*; D012189:Retrospective Studies; D013924:Thrombophlebitis / Q000150:complications / Q000209:etiology*
D009077:Mucins