The synthesis of cholesteryl alkyl ethers.
Seventeen cholesteryl alkyl ethers were synthesized through alcoholysis of cholesterol p-toluenesulfonate. This method was found superior to the etherification of sodium or potassium cholesterylate with alkyl halides or methanesulfonates, especially for the preparation of long-chain unsaturated aklyl ethers of [7(m)-3H]cholesterol of high specific activity.
D002784:Cholesterol / Q000031:analogs & derivatives*; D007202:Indicators and Reagents; D007553:Isotope Labeling / Q000379:methods; D009682:Magnetic Resonance Spectroscopy; D008722:Methods; D009904:Optical Rotation; D013053:Spectrophotometry; D013329:Structure-Activity Relationship; D014316:Tritium
D007202:Indicators and Reagents; D014316:Tritium; D002784:Cholesterol