title: [Effect of aprindine in patients with normal and pre-damaged impulse forming and excitation conducting system/First communication; Sinus node function (author's transl)].
abstract: In 18 patients the influence of aprindine on sinus node function has been evaluated. The criteria were heart rate in spontaneous rhythm, sinus node recovery time (SRT), and the warm-up period after atrial stimulation with frequencies between 90 and 140/min. After aprindine the spontaneous rate increased significantly, whereas SRT and the warm-up period were not affected significantly. The patients with sinu-atrial disease showed a shortening of the spontaneous cycle-length and a decrease in SRT after aprindine. The results are discussed regarding the electrophysiological characteristics of the sinus node (slow current, automaticity) and their changes produced by stimulation and aprindine.
mesh_terms: D001073:Aprindine / Q000494:pharmacology*; D004562:Electrocardiography; D005260:Female; D006331:Heart Diseases / Q000503:physiopathology; D006801:Humans; D007192:Indenes / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D012849:Sinoatrial Node / Q000187:drug effects*
chemical_list: D007192:Indenes; D001073:Aprindine
vernacular_title: Die Wirkung von Aprindin bei Patienten mit normalem und vorgeschädigtem Reizbildungs- und Erregungsleitungssystem. 1. Mitteilung: Sinusknotenfunktion.