title: Radiation effects on the parotid gland of mammals. Part 4: Biochemical and morphological changes after local irradiation.
abstract: A morphological and biochemical study was done on rat parotids to evaluate the modifications after 2400 rad in the parotid area only. As previously observed, whole-body irradiation with lower doses produced only slight effects on the gland. The enzymes peculiar to glandular function decreased significantly 3 days after irradiation, later they fluctuated on control values. Increase in alkaline  phosphatase, LAP, and decrease in protein content was a constant result. Beta-glucuronidase only among lysosomal enzymes increased significantly at some intervals. Morphological alterations in the glandular sections of the sacrificed animals appeared modest and mostly  consisted of progressive fibrosis.
mesh_terms: D000469:Alkaline Phosphatase / Q000032:analysis; D000818:Animals; D005260:Female; D005966:Glucuronidase / Q000032:analysis; D007931:Leucyl Aminopeptidase / Q000032:analysis; D010306:Parotid Gland / Q000201:enzymology / Q000473:pathology / Q000528:radiation effects*; D011829:Radiation Dosage; D051381:Rats; D013997:Time Factors
chemical_list: D000469:Alkaline Phosphatase; D005966:Glucuronidase; D007931:Leucyl Aminopeptidase