Action of surfactants on egg lecithin liposomes.
The lytic action of several homologous series of surfactants including N-acyl derivatives of the Na-salt of amino acids on the egg lecithin multilamellar liposomes was examined. The affinity for the lipid membrane and the solubilising capacity of the agents were estimated. The contribution of a CH2 group and that of the polar head group of surfactants to the free energy of the agent's binding to the membrane were evaluated. The results obtained indicate that the contribution of a CH2 group to the free binding energy depends on the nature of the surfactants' head group. This dependence is attributed to either various localisation of the agent's molecules in the lipid bilayer or to different properties of the agent's hydrocarbon tails. The contributions of the head groups of the surfactants are assumed to reflect the affinity of these head groups for the lecithin polar head group at the membrane interface. The results obtained indicate some degree of specificity involved in the interactions of the head groups.
D008051:Lipid Bilayers; D008081:Liposomes; D008968:Molecular Conformation; D010713:Phosphatidylcholines; D013329:Structure-Activity Relationship; D013501:Surface-Active Agents
D008051:Lipid Bilayers; D008081:Liposomes; D010713:Phosphatidylcholines; D013501:Surface-Active Agents