Pulmonary fibrosis caused by delayed-type hypersensitivity reaction in guinea pigs.
Guinea pigs were immunized with complete Freund adjuvant and PPD was inhaled seven times at three-week intervals. Histological examination revealed a tendency to fibrotic changes in comparison with control animals.
D000818:Animals; D003094:Collagen; D006168:Guinea Pigs; D006965:Hyperplasia / Q000473:pathology; D006968:Hypersensitivity, Delayed / Q000150:complications*; D008168:Lung / Q000473:pathology; D008297:Male; D009504:Neutrophils / Q000473:pathology; D010586:Phagocytes / Q000473:pathology; D011658:Pulmonary Fibrosis / Q000209:etiology*; D013997:Time Factors; D014373:Tuberculin / Q000276:immunology
D014373:Tuberculin; D003094:Collagen