[Corticosteroids and the adrenaline activation of glycogen phosphorylase in heart tissue].
Study of changes in the glycogen phosphorylase activity under the effect of adrenaline in the hearts of intact, adrenalectomized and sham-adrenalectomized rats demonstrated that stress increased the phosphorylase A level considerably. Against the background of these changes perfusion of the heart with 0.5.10(-7)M adrenaline produced no further elevation of the enzyme activity. Following restoration of the basal phosphorylase A to the normal level adrenaline again acquired the capacity to Phosphorylase activation. Stable absence of response of the heart tissue to adrenaline by increase of phosphorylase A activity was noted on the 5th postadrenalectomy day; this apparently followed disturbances in the potassium ions accumulation in the cells.
D000305:Adrenal Cortex Hormones / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D006005:Phosphorylases / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D000305:Adrenal Cortex Hormones; D006005:Phosphorylases; D002118:Calcium; D004837:Epinephrine
Kortikosteroidy i aktivatsiia adrenalinom glikogenfosforilazy v serdechnoĭ tkani.