Nicotine and amphetamine: differential tolerance and no cross-tolerance for ingestive effects.
Rats chronically treated twice daily with nicotine (0.4 mg/kg, SC) or d,1-amphetamine (1.5 mg/kg, SC) exhibited different patterns of anorexia, hypodipsia, and body weight loss. Amphetamine-treated rats developed tolerance to these ingestive effects and to weight loss, whereas nicotine-injected rats did not. There was little, if any, evidence for cross-tolerance when the drugs were switched between the two groups. These results indicate that different mechanisms underlie the ingestive effects of nicotine and amphetamine.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D000855:Anorexia / Q000139:chemically induced; D001835:Body Weight / Q000187:drug effects*; D004361:Drug Tolerance; D004435:Eating / Q000187:drug effects*; D008297:Male; D009538:Nicotine / Q000494:pharmacology*; D051381:Rats
D009538:Nicotine; D000661:Amphetamine