Plasma prostaglandin F levels and malignant tumours of the female genital tract.
Plasma prostaglandin F (PGF) was measured by a radioimmunoassay method in 24 subjects with tumours of the female genital tract. Levels in the tumour group ranged from 25 pg/ml to 134 pg/ml and were almost all greater than the values observed in a control group of 41 healthy women who had a mean (+/-SD) level of 21 (+/-3.4)pg/ml. There was a relationship between plasma PGF levels and the stage of the disease. Patients with resectable tumours showed a fall in PGF levels postoperatively and those with disseminated malignancy demonstrated increasing levels as the disease progressed. Plasma PGF may provide a clinical prognostic marker in the management of patients with malignant tumours.
D000328:Adult; D005260:Female; D005833:Genital Neoplasms, Female / Q000097:blood* / Q000473:pathology / Q000628:therapy; D006801:Humans; D009367:Neoplasm Staging; D011460:Prostaglandins F / Q000097:blood*
D011460:Prostaglandins F