title: [Risk factor changes in four years in the Rome Project of Coronary Heart Disease Prevention (PPCC) (AUTHOR'S TRANSL)].
abstract: The Rome Project of Coronary Heart Disease Prevention (PPCC) is a primary multifactorial preventive trial of CHD representing the Italian section of the WHO European Multifactor Preventive Trial of CHD. It operates on 6,000 men aged 40--59 at entry enrolled in occupational groups and randomly divided into treated and controls. The intervention, directed to modify the levels of some risk factors is individually-oriented in subjects belonging to the upper 30% of a risk score computed in the treatment groups, is based on mass health education in the remaining 70% of treatment groups, while no treatment is provided by the Research Group to the controls. Four years after the start of the trial, the levels out of certain risk factors considered in this analysis (body weight, systolic and diastolic blood pressure, serum cholesterol) showed, in the treatment groups, a significant decreasing trend as compared to those observed in control groups, both considering the subgroup at relatively high risk and the random one representing the whole populations. Daily cigarette consumption significantly decreased in high risk subgroups but none in random ones, while serum triglycerides did not decrease in either subgroups. The estimated theoretical risk of CHD in five years computed by multiple logistic function showed a 39% net reduction in treatment high risk subgroups and a 31% net reduction in the whole treatment populations.
mesh_terms: D000328:Adult; D000367:Age Factors; D001794:Blood Pressure; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D003327:Coronary Disease / Q000453:epidemiology / Q000517:prevention & control*; D006801:Humans; D007558:Italy; D008297:Male; D008875:Middle Aged; D009790:Occupations; D012306:Risk; D012907:Smoking / Q000150:complications; D014280:Triglycerides / Q000097:blood
chemical_list: D014280:Triglycerides; D002784:Cholesterol
vernacular_title: Variazioni dei fattori di rischio in quattro anni nel Progetto Romano di Prevenzione della Cardiopatia Coronarica (PPCC).