The relationship between plasma biotin concentration and circulating leucocyte beta-methylcrotonyl-CoA carboxylase and propionyl-CoA carboxylase.
1. A newly developed biotin assay was used to monitor plasma and urinary biotin concentration after the oral administration of biotin. 2. In two normal subjects, leucocyte propionyl-CoA carboxylase and beta-methylcrotonyl-CoA carboxylase were markedly stimulated after the administration of biotin.
D000328:Adult; D001710:Biotin / Q000097:blood* / Q000494:pharmacology / Q000652:urine; D019735:Carbon-Carbon Ligases; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D008025:Ligases / Q000097:blood*; D008297:Male
D001710:Biotin; D008025:Ligases; D019735:Carbon-Carbon Ligases; C022458:propionyl CoA carboxylase (ATP-hydrolyzing); C021573:methylcrotonoyl-CoA carboxylase