Effect of 1 alpha-hydroxy-cholecalciferol and varying phosphorous content in the diet on calcium phosphorous metabolism in hypokinetic rats.
Hypokinesia induces mineral changes, including changes in calcium and phosphorus metabolism, which involve their increased renal excretion, deposition in soft tissues, and development of osteoporosis. These experiments were designed in order to ascertain the role of active metabolites (hydroxy-cholecalciferol) and changes in phosphorus in the diet on calcium accumulation in bone, soft tissue, and renal calcinosis, and changes in calcium-phosphorus metabolism in rats during prolonged and severe hypokinesia.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D002114:Calcinosis / Q000209:etiology; D002118:Calcium / Q000378:metabolism*; D004032:Diet / Q000009:adverse effects; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D008297:Male; D009043:Motor Activity; D010758:Phosphorus / Q000378:metabolism*; D051381:Rats
D006887:Hydroxycholecalciferols; D010758:Phosphorus; D002118:Calcium