Nuclear activation of carbon tetrachloride and chloroform.
Highly purified rat liver nuclear preparations are able to activate anaerobically CCl4 and aerobically CHCl3 to reactive metabolites that bind to lipids and proteins. Activity in nuclear preparations is smaller than in microsomes but of the same order of magnitude.
D000332:Aerobiosis; D000693:Anaerobiosis; D000818:Animals; D001711:Biotransformation; D002251:Carbon Tetrachloride / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D002725:Chloroform / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008297:Male; D009249:NADP / Q000378:metabolism; D051381:Rats
D009249:NADP; D002725:Chloroform; D002251:Carbon Tetrachloride