High-resolution particle analysis--its application to platelet counting and suggestions for further application in blood cell analysis.
The characteristics of an instrument for high-resolution particle analysis in flow are discussed. It employs a combination of hydrodynamic focusing, fluid resistors, and electronic techniques to achieve precision and ease of use heretofore unobtainable in a moderate-cost clinical instrument. Its application to whole blood platelet counting is discussed, and suggestions are made for its possible application to a wide variety of blood cell measurements.
D000818:Animals; D004553:Electric Conductivity; D004909:Erythrocyte Indices; D004910:Erythrocyte Membrane / Q000502:physiology; D006384:Hemagglutination; D006400:Hematocrit; D006403:Hematologic Tests / Q000295:instrumentation*; D006801:Humans; D007958:Leukocyte Count; D051379:Mice; D009996:Osmotic Fragility; D010974:Platelet Aggregation; D010976:Platelet Count / Q000295:instrumentation*; D010979:Platelet Function Tests / Q000295:instrumentation