title: H-Y evolution.
abstract: The female:male sex ratio in litters born to C57 black mice immunized with male spleen preparations is 2:1 and males were stillborn. In addition Drosophila busckii males are H-Y antigen positive. It is argued that H-Y is the primary testicular determinant and that this role is evolutionarily ancient.
mesh_terms: D000818:Animals; D005260:Female; D006182:H-Y Antigen / Q000235:genetics*; D006801:Humans; D008297:Male; D051379:Mice; D012732:Sex Determination Analysis; D013737:Testis / Q000196:embryology
chemical_list: D006182:H-Y Antigen