Effects of combined procetofene--nicotinic acid therapy in treatment of hypertriglyceridaemia.
Eight males with hypertriglyceridaemia were treated with a combination of procetofene (400 mg/day) and nicotinic acid (4 g/day) for 6 weeks. Previous therapy with only procetofene (400 mg/day) had given a certain, but not complete degree of normalisation. The combined treatment lowered the VLDL TG concentration values from 3.21 to 1.11 mmol/l and increased the HDL cholesterol concentration from 1.04 to 1.43 mmol/l (P less than 0.05 for both). The significant LDL cholesterol increase from 4.45 to 5.27 mmol/l, observed during treatment with procetofene only, reverted to 4.05 mmol/l when combined therapy was given. This drug combination may be a valuable tool to obtain maximum reduction of elevated TG in the therapy of hypertriglyceridaemia.
D000368:Aged; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D011345:Fenofibrate / Q000627:therapeutic use*; D006801:Humans; D006949:Hyperlipidemias / Q000188:drug therapy*; D008075:Lipoproteins, HDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009539:Nicotinic Acids / Q000627:therapeutic use*; D011422:Propionates / Q000627:therapeutic use*; D014280:Triglycerides / Q000097:blood*
D008075:Lipoproteins, HDL; D008079:Lipoproteins, VLDL; D009539:Nicotinic Acids; D011422:Propionates; D014280:Triglycerides; D002784:Cholesterol; D002994:Clofibrate; D011345:Fenofibrate