Preliminary results on the action of dihydroxydibutylether on the lithogenic index of patients with calculosis of the gall-bladder.
Oral administration of 900 mg daily of dihydroxydibutylether to patients with cholesterol stones in the gall-bladder, reduced the lithogenic index of the bile, whose mean value shifted from 1.64 to 1.03 (p less than 0.01) after 20 days of treatment. Reduction of lithogenic index must be ascribed exclusively to the reduced biliary concentration of cholesterol.
D000328:Adult; D000368:Aged; D001646:Bile / Q000032:analysis; D001647:Bile Acids and Salts / Q000032:analysis; D000440:Butanols / Q000627:therapeutic use*; D002756:Cholagogues and Choleretics / Q000627:therapeutic use*; D002769:Cholelithiasis / Q000188:drug therapy* / Q000378:metabolism; D002784:Cholesterol / Q000032:analysis; D004987:Ethers / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008875:Middle Aged; D010743:Phospholipids / Q000032:analysis
D001647:Bile Acids and Salts; D000440:Butanols; D002756:Cholagogues and Choleretics; D004987:Ethers; D010743:Phospholipids; D002784:Cholesterol; C000987:4,4'-oxydi-2-butanol