Bioequivalence of subcutaneous calcium and sodium heparins.
The bioequivalence of subcutaneous porcine calcium and sodium heparins was studied in 48 normal male subjects randomly assigned to 1 of 4 study groups. Each subject received a single subcutaneous injection of 15,000 U of calcium heparin or 1 of 3 sodium heparins. Serial coagulation studies (Lee-White clotting time, activated partial thromboplastin time, thrombin calcium clotting time, and heparin level) were performed over 10 hr. There were no significant differences in anticoagulant effect between groups.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001780:Blood Coagulation Tests; D002118:Calcium; D006493:Heparin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D007279:Injections, Subcutaneous; D008297:Male; D008875:Middle Aged; D012964:Sodium; D013810:Therapeutic Equivalency
D006493:Heparin; D012964:Sodium; D002118:Calcium