Progressive retinal atrophy in the Samoyed.
In Samoyeds 2-5 years old, progressive retinal atrophy was evidenced ophthalmoscopically by peripheral tapetal hyperreflectivity and vascular attenuation, with marked generalized retinal thinning and vascular attenuation at 5-8 years. Pupil response remained active until late in the disease. Histologically, early retinal development was normal, with lesion onset paralleling that of ERG abnormalities. Pedigree examination and test-breeding results were compatible with simple autosomal recessive inheritance.
D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000235:genetics; D004285:Dogs; D005260:Female; D008297:Male; D012162:Retinal Degeneration / Q000175:diagnosis / Q000235:genetics / Q000662:veterinary*