Multicore disease.
Two additional cases of multicore disease are presented, the main reason being the rarity of presentation in adults. It would appear that when this disease occurs in adults the prognosis is not as benign as when it occurs in infancy. We were able to confirm that the serum enzyme levels are normal in this disease and that the condition is best shown up with oxidative enzyme staining. There is a gradual disappearance of the type 1 motor neurons so that, by adulthood, the number of type 2 fibres is extremely few. In this respect the disease bears a similarity to central core disease and nemaline rod disease.
D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009132:Muscles / Q000473:pathology* / Q000648:ultrastructure; D009468:Neuromuscular Diseases / Q000473:pathology* / Q000503:physiopathology