Osmotic fragility and lipid peroxidation of irradiated erythrocytes in the presence of radioprotectors.
Gamma radiation causes a decrease in the osmotic fragility of porcine erythrocytes and induces peroxidation of membrane lipids, as reflected by an increase in malondialdehyde content. With respect to osmotic fragility all the protectors used have the radioprotective effect. Malondialdehyde content was reduced in the presence of catalase, cysteine and glutathione, whereas SOD had no protective effect.
D000818:Animals; D002374:Catalase / Q000494:pharmacology; D003545:Cysteine / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000528:radiation effects*; D004912:Erythrocytes / Q000528:radiation effects*; D005978:Glutathione / Q000494:pharmacology; D008054:Lipid Peroxides / Q000097:blood*; D008315:Malondialdehyde / Q000097:blood; D008563:Membrane Lipids / Q000097:blood*; D009996:Osmotic Fragility / Q000187:drug effects / Q000528:radiation effects*; D011837:Radiation-Protective Agents; D013482:Superoxide Dismutase / Q000494:pharmacology; D013552:Swine
D008054:Lipid Peroxides; D008563:Membrane Lipids; D011837:Radiation-Protective Agents; D008315:Malondialdehyde; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D003545:Cysteine