A trial of intraarticular orgotein, a superoxide dismutase, in experimentally-induced osteoarthritis.
Intraarticular injections of orgotein, a metalloprotein with superoxide dismutase activity, did not ameliorate experimentally-induced osteoarthritis in the rabbit. Reduction of sulfate incorporation by cartilage of operated osteoarthritic knees with injection of saline-sucrose placebo and orgotein in saline-sucrose vehicle was observed. Repeated intraarticular injections of both orgotein in a sucrose-saline vehicle, and sucrose-saline placebo administered separately induced a severe synovitis in both osteoarthritic and normal knees.
D000818:Animals; D002356:Cartilage / Q000473:pathology; D002417:Cattle; D004195:Disease Models, Animal; D004341:Drug Evaluation; D005260:Female; D007270:Injections, Intra-Articular; D008667:Metalloproteins / Q000008:administration & dosage / Q000627:therapeutic use*; D010003:Osteoarthritis / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D011817:Rabbits; D013431:Sulfates / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism*
D008667:Metalloproteins; D013431:Sulfates; D013482:Superoxide Dismutase; C005180:orgotein