Comparison of the natural humoral antitumor reactivity of different strains of mice.
Normal serum from C3Hf mice showed a complement-dependent cytotoxic reactivity against EL4 lymphoma cells, starting from 2 to 3 months of age, whereas normal serum from BALB/c and C57BL/6J mice became reactive only at a later age. The cytotoxins of normal sera of the 3 strains, as well as of a C57BL antiembryo antiserum studied in parallel, belong to the IgM class. When absorption were performed, using a variety of absorbing cells, marked differences were found among the sera, which according to their behavior could be divided in two groups: one group comprises the BALB/c and the C57BL sera, the other group the C3Hf serum from both young and old mice and the antiembryo antiserum. The reactivity of the 3 latter sera seems to be directed against specifities related to an ecotropic N-tropic virus, which on the contrary did not seem to be involved in the reactivity of BALB/c and C57BL sera. The C57BL antiembryo antiserum obtained by immunization with C3Hf embryos behaved differently from the C57BL normal serum and similarly to the C3Hf normal serum.
D000818:Animals; D000917:Antibody Formation; D000918:Antibody Specificity; D000951:Antigens, Neoplasm / Q000276:immunology; D000956:Antigens, Viral / Q000276:immunology; D003165:Complement System Proteins / Q000276:immunology; D003603:Cytotoxins / Q000276:immunology; D004622:Embryo, Mammalian / Q000276:immunology; D007106:Immune Sera; D007113:Immunity, Innate; D007075:Immunoglobulin M / Q000276:immunology; D007942:Leukemia, Experimental / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008809:Mice, Inbred C3H / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000276:immunology; D008815:Mice, Inbred Strains / Q000276:immunology*; D009374:Neoplasms, Experimental / Q000276:immunology*; D011817:Rabbits
D000951:Antigens, Neoplasm; D000956:Antigens, Viral; D003603:Cytotoxins; D007106:Immune Sera; D007075:Immunoglobulin M; D003165:Complement System Proteins