[A fortultousness association: Bartter's syndrome and chondrocalcinosis (author's transl)].
Two adults patients presenting Bartter's syndrome have been studied for 9 years in one case, 7 years in the other. Both were affected with chondrocalcinosis. This association does not seem to be coincididental but suggests a pathogenic link between Bartter's syndrome and chondrocalcinosis; the two patients presented hypomagnesemia which, inhibiting intrasynovial pyrophosphatase, induces calcium pyrophosphate crystals deposits on fibrocartilages. Otherwise, excessive daily urinary excretion of PG E2 and PG F2 alpha was found in both patients. Indomethacin (150 mg daily) decreased urinary excretion of PG to normal values in the two cases, Kalaemia was completely normalized in one case, partially in the other.
D000328:Adult; D001477:Bartter Syndrome / Q000150:complications* / Q000188:drug therapy / Q000378:metabolism; D002131:Calcium Pyrophosphate / Q000378:metabolism; D002356:Cartilage / Q000378:metabolism; D002805:Chondrocalcinosis / Q000150:complications* / Q000378:metabolism; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications*; D007213:Indomethacin / Q000627:therapeutic use; D008274:Magnesium / Q000097:blood; D008297:Male; D008875:Middle Aged; D011458:Prostaglandins E / Q000652:urine; D011460:Prostaglandins F / Q000652:urine
D011458:Prostaglandins E; D011460:Prostaglandins F; D008274:Magnesium; D002131:Calcium Pyrophosphate; D007213:Indomethacin
Syndrome de Bartter et chondrocalcinose. Une association non fortuite.