Serum histidine in rheumatoid arthritis: changes induced by antirheumatic drug therapy.
Serum free histidine levels were studied in 15 patients with rheumatoid arthritis treated with D-penicillamine and 15 patients treated with hydroxychloroquine for 6 months. Both drugs produced improvement in the majority of patients, measured in terms of changes in 5 clinical parameters and plasma viscosity. A significant increase in serum histidine was observed only with D-penicillamine. This action, not seen with other specific antirheumatoid drugs may reflect a specific action of the drug.
D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000097:blood* / Q000188:drug therapy / Q000378:metabolism; D005260:Female; D006639:Histidine / Q000097:blood*; D006801:Humans; D006886:Hydroxychloroquine / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000008:administration & dosage / Q000627:therapeutic use*
D006639:Histidine; D006886:Hydroxychloroquine; D010396:Penicillamine