Rose bengal clearance during hepatic regeneration in rats.
Intravenous I131 Rose bengal clearance was conducted in partially hepatectomized rats with a dose of 1 muCi/100 gm body weight. Blood samples were taken at regular intervals up to 25 minutes which were suitable diluted to count the remaining radioactivity. From these values t1/2 and the clearance constants were worked out upto a period of 120 hr after partial hepatectomy. An analysis of the results show that there is a linear correlation between the rose bengal clearance and the regenerating hepatic mass which may be used for quantitative assessment of functional hepatic mass.
D000818:Animals; D006207:Half-Life; D006498:Hepatectomy; D007457:Iodine Radioisotopes; D008099:Liver / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D051381:Rats; D012395:Rose Bengal; D013997:Time Factors
D007457:Iodine Radioisotopes; D012395:Rose Bengal