Induction of xenobiotic metabolism in rats by short-term administration of brominated diphenyl ethers.
Commercial preparations of fire retardant brominated diphenyl ethers were tested along with bis (p-bromophenyl) ether and diphenyl ether for their ability to alter xenobiotic metabolism. The materials, 0.1 mmol/kg/day, were administered p.o. to male rats for 14 days. Pentabromodiphenyl and octabromodiphenyl ether preparations increased O-ethyl O-p-nitrophenyl phenylphosphonothioate (EPN) detoxification, p-nitroanisole demethylation, NADPH-cytochrome c reductase, cytochrome P-450, liver weight, UDP-glucuronyltransferase and benzo[a]pyrene hydroxylase. Diphenyl ether increased only EPN detoxification and decabromodiphenyl ether only liver weight. Bis(p-bromophenyl) ether increased liver weight, cytochrome c reductase and cytochrome P-450. The data indicate that these materials are inducers of xenobiotic metabolism with activity dependent upon degree of bromination.
D000818:Animals; D001966:Bromine / Q000633:toxicity; D004790:Enzyme Induction / Q000187:drug effects; D005411:Flame Retardants / Q000633:toxicity*; D008658:Inactivation, Metabolic; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010647:Phenyl Ethers / Q000633:toxicity*; D051381:Rats; D013329:Structure-Activity Relationship
D005411:Flame Retardants; D010647:Phenyl Ethers; D001966:Bromine