title: Orotic acid prevents changes in cardiac sarcolemmal glycoproteins and contractility associated with muscular dystrophy in hamsters.
abstract: Orotic acid included in the diet of cardiomyopathic hamsters during the myolytic phase of the disease (30-60 days of age) prevented the reduction in cardiac sarcolemmal sialic acid, calcium binding, sialyltransferase activity and contractile activity associated with the cardiomyopathy.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism; D006224:Cricetinae; D006023:Glycoproteins / Q000032:analysis*; D066298:In Vitro Techniques; D009137:Muscular Dystrophy, Animal / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000032:analysis*; D009963:Orotic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D012508:Sarcolemma / Q000032:analysis; D012794:Sialic Acids / Q000032:analysis; D012799:Sialyltransferases / Q000032:analysis
chemical_list: D006023:Glycoproteins; D012794:Sialic Acids; D009963:Orotic Acid; D012799:Sialyltransferases; D002118:Calcium