[Data on the disorder in calcium accumulation and binding by fatty tissue cellular membranes in rats with spontaneous hypertension].
The Ca-binding and Ca-accumulating capacity of the adipocyte membranes was studied in rats with spontaneous genetic hypertension (SHR) by the method of isotope exchange. It is shown that ATP-dependent calcium absorption is increased in the mitochondria and reduced in the endoplasmic reticulum of adipocytes of SHR rats as compared to that in normotensive animals. The ATP-independent hinding of calcium by the plasmic membranes of SHR rat adipocytes is reduced. The disclosed disorders of the membrane function may cause an increase in the content of free intracellular calcium in the adipocytes and explain the increased sensitivity of fat tissue to the effect of lipolytic hormones which was revealed earlier.
D000273:Adipose Tissue / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004721:Endoplasmic Reticulum / Q000378:metabolism; D004789:Enzyme Activation; D005609:Free Radicals; D006973:Hypertension / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D005609:Free Radicals; D002118:Calcium
Dannye o narushenii akkumuliatsii i sviazyvaniia kal'tsiia membranami kletok zhirovoĭ tkani u krys so spontannoĭ gipertenzieĭ.