Studies on Cob (Colton) antigen and anti-Cob.
Using a reliable and strong reacting antiserum of the rare anti-Cob specificity, it was shown that the Cob antigen was fully developed at birth. Gene dosage effect could not be demonstrated. The frequency of Co(b+) persons in the Danish population (7.8%) was found not to differ from other Caucasian populations. The antibody belonged to immunoglobulin class IgG without ability of fixing complement in vitro.
D001782:Blood Donors; D001789:Blood Group Antigens / Q000235:genetics / Q000276:immunology; D003168:Complement Fixation Tests; D003718:Denmark; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D007231:Infant, Newborn; D007518:Isoantibodies / Q000276:immunology*
D001789:Blood Group Antigens; D007074:Immunoglobulin G; D007518:Isoantibodies