Inhibition of Leishmania donovani amastigote-to-promastigote transformation by infected hamster spleen lymphocyte lysates.
Leishmania donovani amastigote-to-promastigote transformation is inhibited by homogenates of infected hamster liver and spleen. This inhibitory activity is localized in the 100,000 g pellet fraction. Tests with lysates of adherent (macrophages) and nonadherent (lymphocytes) spleen cells indicated that the inhibitory activity resided in the lymphocytes, specifically in the 100,000 g pellet fraction.
D000818:Animals; D002498:Centrifugation; D006224:Cricetinae; D007891:Leishmania / Q000254:growth & development*; D007898:Leishmaniasis, Visceral / Q000097:blood* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008214:Lymphocytes / Q000502:physiology*; D008264:Macrophages / Q000502:physiology; D008297:Male; D008647:Mesocricetus; D013154:Spleen / Q000473:pathology