title: Hypergravity and estrogen effects on avian anterior pituitary growth hormone and prolactin levels.
abstract: Developing female chicks with fractured right radii were maintained for 14 d at either earth gravity (1 G) or a hypergravity state (2 G). The birds at 1 G were divided into groups which received daily injections of 1) saline, 2) 200 micrograms estrone, and 3) 400 micrograms estrone for 14 d. The 2-G birds were divided into three similarly treated groups. All 2-G birds showed significantly lower body weights than did 1-G birds. Anterior pituitary (AP) glands were excise; and analyzed for growth hormone and prolactin content by analytical electrophoresis. The 1-G chicks receiving either dose of daily estrogen showed increased AP growth hormone levels, whereas hypergravity alone did not affect growth hormone content. Chicks exposed to daily estrogen and hypergravity displayed reduced growth hormone levels. AP prolactin levels were slightly increased by the lower daily estrogen dose in 1-G birds, but markedly reduced in birds exposed only to hypergravity. Doubly-treated chicks displayed normal prolactin levels. Reduced growth in 2-G birds might be due, in part, to reduced AP levels of prolactin and/or growth hormone.
mesh_terms: D000818:Animals; D001835:Body Weight; D002645:Chickens / Q000254:growth & development; D004970:Estrone / Q000494:pharmacology*; D005260:Female; D006112:Gravitation; D013006:Growth Hormone / Q000032:analysis*; D010903:Pituitary Gland, Anterior / Q000032:analysis* / Q000187:drug effects; D011388:Prolactin / Q000032:analysis*
chemical_list: D004970:Estrone; D011388:Prolactin; D013006:Growth Hormone