Lichen sclerosus et atrophicus, multiple dysplastic keratoses, and squamous-cell carcinoma of the glans penis.
A man who had been circumcised in adulthood developed, in sequence, balanitis xerotica obliterans (lichen sclerosus et atrophicus), multiple dysplastic keratoses, and a superficial, well-differentiated squamous-cell carcinoma on the glans penis. Squamous-cell carcinoma that develops after circumcision in adulthood tends to be more aggressive in biologic behavior and more malignant-looking in histology. Cancer developing within lesions of lichen sclerosus et atrophicus has been reported rarely.
D001446:Balanitis / Q000150:complications* / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000473:pathology; D002944:Circumcision, Male; D006801:Humans; D007642:Keratosis / Q000150:complications* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010412:Penile Neoplasms / Q000150:complications* / Q000473:pathology; D012871:Skin Diseases / Q000150:complications* / Q000473:pathology