2-Halogeno-ethanols as an uncoupler of phosphorylation in rat liver mitochondria.
2-Chloroethanol, 2-bromoethanol and 2,2,2-trifluoroethanol at a concentration of 0.79 vol.% stimulated state 4 respiration and released oligomycin inhibition of state 3 respiration. 2-Fluoroethanol and 1-propanol at the same concentration did not affect the respiration.
D000433:1-Propanol / Q000494:pharmacology; D000818:Animals; D002728:Chlorohydrins / Q000494:pharmacology*; D004140:Dinitrophenols / Q000494:pharmacology; D000431:Ethanol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005023:Ethylene Chlorohydrin / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D051381:Rats; D013385:Succinate Dehydrogenase / Q000378:metabolism; D014270:Trifluoroethanol / Q000494:pharmacology*; D014475:Uncoupling Agents
D002728:Chlorohydrins; D004140:Dinitrophenols; D014475:Uncoupling Agents; D000431:Ethanol; C001236:2-fluoroethanol; D014270:Trifluoroethanol; D005023:Ethylene Chlorohydrin; D000433:1-Propanol; D013385:Succinate Dehydrogenase; C025475:ethylene bromohydrin