Upper genital tract changes and pregnancy outcome in offspring exposed in utero to diethylstilbestrol.
Hysterosalpingography (HSG) was performed on 267 diethylstilbestrol (DES)-exposed women. One hundred eighty-five (69%) of these women demonstrated an abnormality and 82 women had normal findings. A relationship between abnormal x-ray findings and structural abnormalities of the cervix and vaginal epithelial changes was noted. Ninety-three women on whom roentgenography was performed had a total of 144 pregnancies. The pregnancy outcome in this group of women was significantly worse than that found in a control population of 87 women who had 147 pregnancies. In addition, women with abnormal x-ray films were found to have a poorer pregnancy outcome than the group of women with normal findings. The women with abnormal x-ray films had more ectopic pregnancies, spontaneous abortions, and premature deliveries than women with normal x-ray films although these differences were not statistically significant. Significantly fewer women with abnormal findings than women with normal x-rays were delivered of term infants.
D000022:Abortion, Spontaneous / Q000139:chemically induced; D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects*; D004054:Diethylstilbestrol / Q000009:adverse effects*; D004848:Epithelium / Q000187:drug effects; D005260:Female; D005328:Fetal Viability; D005333:Fetus / Q000187:drug effects; D006801:Humans; D007047:Hysterosalpingography; D007231:Infant, Newborn; D007234:Infant, Premature; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced*; D011271:Pregnancy, Ectopic / Q000139:chemically induced; D014599:Uterus / Q000187:drug effects*; D014621:Vagina / Q000187:drug effects*
D004054:Diethylstilbestrol