title: Coumarin necrosis.
abstract: Necrosis of the skin developed soon after the initiation of coumarin therapy in an elderly woman. Inadvertent rechallenge resulted in similar lesions. Coumarin necrosis is a poorly understood phenomenon unlikely to respond to therapy. Fortunately, its incidence is quite rare, considering the widespread use of this anticoagulant.
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D009336:Necrosis; D012867:Skin / Q000473:pathology*; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D014859:Warfarin