Potentiation of warfarin anticoagulation by sulfisoxazole.
The prothrombin time (PT) of a patient undergoing warfarin sodium anticoagulation became elevated when sulfisoxazole was given concurrently. The warfarin dose index is used to demonstrate that this PT prolongation was the result of a warfarin-sulfisoxazole interaction. The mechanism of this interaction may involve displacement of warfarin from serum albumin. Sulfisoxazole should be used cautiously, if at all, in patients taking warfarin.
D000368:Aged; D001777:Blood Coagulation / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D006801:Humans; D011655:Pulmonary Embolism / Q000188:drug therapy; D013444:Sulfisoxazole / Q000009:adverse effects*; D014552:Urinary Tract Infections / Q000188:drug therapy; D014859:Warfarin / Q000037:antagonists & inhibitors*
D014859:Warfarin; D013444:Sulfisoxazole