title: A virilizing hilus-cell tumour in an African patient with Turner's syndrome.
abstract: A 26-year-old African female presented with primary amenorrhoea and genital abnormalities. She had the physical stigmata of Turner's syndrome and a 45, X karyotype. Severe masculinization of the external genitalia, apparently present from birth, was present and a laparotomy revealed a hilus-cell tumour of the right streak gonad. Clitoridectomy and vaginoplasty were performed but subsequent oestrogen therapy failed to produce breast development.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D007984:Leydig Cell Tumor / Q000150:complications* / Q000601:surgery; D010051:Ovarian Neoplasms / Q000150:complications* / Q000601:surgery; D014424:Turner Syndrome / Q000150:complications* / Q000628:therapy; D014770:Virilism / Q000209:etiology* / Q000628:therapy