The fibrinolytic response in injured animal tissues normally low in fibrinolytic activity.
Rabbit skin, normally of low fibrinolytic activity, and guinea-pig skin, of medium activity, after crush injury or after the intradermal or subcutaneous injection of aluminum hydroxide, show a remarkable increase in fibrinolytic activity. The activity is caused by a plasminogen activator and is related to blood vessels. Occasionally, intense fibrinolytic activity was also observed in some specimens collected from various other organs normally low in activity. Thus two specimens of rabbit aorta, one specimen of rabbit trachea and one specimen of rabbit stomach showed increased activity related to pathological processes. One specimen of guinea-pig rectum showed intense fibrinolytic activity along the serosa.
D000818:Animals; D005342:Fibrinolysis; D006168:Guinea Pigs; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000166:cytology / Q000293:injuries; D012879:Skin Physiological Phenomena