Antitumor activity of hydrazones and adducts between aromatic aldehydes and p-(3,3-dimethyl-1-triazeno)benzoic acid hydrazide.
Hydrazones and adducts between aromatic aldehydes and p-(3,3-dimethyl-1-triazeno)benzoic acid hydrazide were synthesized and tested for antitumor activity. Two adducts derived from 2,6-dinitro- and 4-cyanobenzaldehyde were active against TLX5 lymphoma in mice. The hydrazone of the latter aldehyde was significantly more active than the adducts.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D006835:Hydrazones / Q000627:therapeutic use*; D008223:Lymphoma / Q000188:drug therapy; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy
D000970:Antineoplastic Agents; D006835:Hydrazones