Differences in proliferation of primary cultures of vascular smooth muscle cells taken from male and female rats.
Vascular smooth muscle cells from thoracic aortas of 10-week-old rats were cultured on different substrates. Cells taken from male animals proliferated more quickly than those taken from females; this was true for all substrates, but the difference was accentuated by growth on collagen membranes. The relationship between these results and the sex-linked incidence of hypertension and atherosclerosis is discussed and a model for future studies proposed.
D000818:Animals; D001013:Aorta, Thoracic / Q000166:cytology; D001808:Blood Vessels / Q000166:cytology*; D002455:Cell Division; D005260:Female; D008297:Male; D009130:Muscle, Smooth / Q000166:cytology* / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D012737:Sex Factors; D014661:Vasoconstriction / Q000187:drug effects
D009638:Norepinephrine