[Dependence of the peripheral blood lymphocyte reaction of schizophrenia patients to concanavalin A stimulation on the clinical parameters of the pathological process].
Studies were performed on an equivalent age group of schizophrenic patients and normal donors to detect the lymphocyte reaction of the peripheral blood to concanavalin A stimulation. It was demonstrated, that in the blood of schizophrenic patients, the part of lymphocytes capable of reacting to stimulation, is 2,3 times less than in the group of normals. The studies showed that the capability of cells to react to stimulation does not depend upon the duration of the disease, the duration of the postmanifest or initial periods, but differs in patients with different forms of schizophrenia. A significant negative correlation was demonstrated between the severity of positive disorders and the lymphocyte response to stimulation.
D000293:Adolescent; D000328:Adult; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D004247:DNA / Q000032:analysis; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D012559:Schizophrenia / Q000097:blood*
D003208:Concanavalin A; D004247:DNA
Zavisimost' reaktsii limfotsitov perifericheskoĭ krovi bol'nykh shizofrenieĭ na stimuliatsiiu konkanavalinom A ot nekotorykh klinicheskikh parametrov patologicheskogo protsessa.