[Comparative study of rifampicin distribution in the body of pregnant and nonpregnant white rats exposed to the antibiotic by inhalation].
When rifampicin was administered to albino rats in the form of inhalations, it was absorbed by the blood and penetrated into various organs, the levels of the antibiotic in the biosubstrates being dependent on its concentration in the inhalation air. Rifampicin distribution in the gravid animals was mainly of the same character as that in the nongravid rats. However, when the animals were exposed to the antibiotic effect during the whole period of the gravidity, a significant increase in the antibiotic levels in the blood and internal organs was observed.
D000042:Absorption; D000818:Animals; D004781:Environmental Exposure; D005260:Female; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D051381:Rats; D012293:Rifampin / Q000378:metabolism*; D013997:Time Factors; D014018:Tissue Distribution
D012293:Rifampin
Sravnitel'noe izuchenie raspredeleniia rifampitsina v organizme beremennykh i neberemennykh belykh krys pri ingaliatsionnom vvedenii antibiotika.