Structure and toxicity of the alkaloids of Russian comfrey (symphytum x uplandicum Nyman), a medicinal herb and item of human diet.
Eight pyrrolizidine alkaloids of hepatotoxic type have been indentified in leaves of Symphytum X uplandicum. The combined alkaloids exhibit chronic hepatotoxicity in rats.
D000470:Alkaloids / Q000633:toxicity; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D008940:Mitotic Index / Q000187:drug effects; D010945:Plants, Edible / Q000032:analysis*; D010946:Plants, Medicinal / Q000032:analysis*; D051381:Rats; D013329:Structure-Activity Relationship
D000470:Alkaloids; D001798:Blood Proteins