Cooperativity of albumin and aggrexons A and B for ADP-induced-aggregation of platelets.
Using extensively washed bovine platelets and a chemically defined medium instead of whole plasma, it was demonstrated that aggregation to a near normal extent was induced by ADP only in the presence of at least the following three components from plasma; albumin, Aggrexon A and Aggrexon B. These three proteins apparently acted cooperatively; the elimination of any one of the above mentioned plasma components from the system resulted in marked reduction of the aggregation.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D001798:Blood Proteins / Q000302:isolation & purification / Q000494:pharmacology*; D002417:Cattle; D011232:Chemical Precipitation; D005340:Fibrinogen; D010974:Platelet Aggregation; D012710:Serum Albumin, Bovine
D001798:Blood Proteins; C023590:aggrexon A; C023591:aggrexon B; D012710:Serum Albumin, Bovine; D000244:Adenosine Diphosphate; D005340:Fibrinogen