title: Identification of degradation products in a phenylbutazone tablet formulation.
abstract: Two previously reported but unidentified phenylburazone degradation products were isolated from a tablet that was stored at 60 degrees for 203 days. The compounds, alpha-(N-phenylcarbamoyl)-N-caproylhydrazobenzene and alpha-hydroxy-alpha-(N-phenylcarbamoyl)-N-caproylhydrazobenzene, were isolated by chromatography, identified by mass and NMR spectrometry, and synthesized by the reaction of aniline with phenylbutazone or its hydroxy analog, respectively.
mesh_terms: D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010653:Phenylbutazone / Q000032:analysis* / Q000592:standards; D013607:Tablets / Q000592:standards
chemical_list: D013607:Tablets; D010653:Phenylbutazone