Endocrine manipulation of the Dunning prostatic adenocarcinoma.
The Dunning animal model was used to evaluate endocrine management of prostatic adenocarcinoma. Hypophysectomy, alone or in combination, and orchiectomy plus stilbestrol were the most effective means of suppressing tumor growth. Medical adrenalectomy by aminoglutethimide administration was as effective as surgical ablation. Accessary organ weights bore no direct relationship to the inhibition of tumor growth.
D000230:Adenocarcinoma / Q000628:therapy*; D000315:Adrenalectomy; D000616:Aminoglutethimide / Q000627:therapeutic use; D000818:Animals; D002369:Castration; D004054:Diethylstilbestrol / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004702:Endocrine Glands / Q000601:surgery*; D005260:Female; D006824:Hybridization, Genetic; D007016:Hypophysectomy; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000628:therapy; D009929:Organ Size; D011471:Prostatic Neoplasms / Q000628:therapy*; D051381:Rats
D000616:Aminoglutethimide; D004054:Diethylstilbestrol