[The use of allopurinol in long-term treatments for optimal effect].
The importance of allopurinol drug formulation is discussed regarding the relationship between allopurinol-oxipurinol pharmacokinetics and the mechanism of action. The oxipurinol plasma levels were simulated basing on a single dose regimen and an oxipurinol plasma half life of 14 hours. From these data it is evident, that during long term treatment of hyperuricemia and gout a sustained release allopurinol-formulation fulfills the requirement of adequately maintained oxipurinol plasma levels.
D000493:Allopurinol / Q000627:therapeutic use*; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D006073:Gout / Q000188:drug therapy*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D010117:Oxypurinol / Q000097:blood / Q000627:therapeutic use; D014527:Uric Acid / Q000097:blood
D014527:Uric Acid; D000493:Allopurinol; D010117:Oxypurinol
Die wirkungsgerechte Anwendung von Allopurinol in der Langzeitbehandlung.