Leishmaniasis: in search of new chemotherapeutic agents.
Members of a class of compounds designated lepidines (8-amino-6-methoxy-4-methylquinoline derivatives) were tested in a hamster-Leishmania donovani model and found to have activity many-fold that of a reference drug meglumine antimoniate. One of them, 8-(7-isopropylaminoheptylamino)-6-methoxy-4-methylquinoline, was found to be 138 times as effective as the standard antimonial drug used.
D000634:Aminoquinolines / Q000627:therapeutic use*; D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D006224:Cricetinae; D007896:Leishmaniasis / Q000188:drug therapy / Q000662:veterinary*; D008297:Male; D008647:Mesocricetus; D012376:Rodent Diseases / Q000188:drug therapy*
D000634:Aminoquinolines; D000981:Antiprotozoal Agents