Sialic acid-depleted red cells following acute myocardial infarction.
A reduction of red cell SA in patients following acute myocardial infarction is reported and the effects of SA-depleted red cells on cardiac index and alveolar capillary blood flow in the dog are described. The mean red cell SA in 26 patients following acute myocardial infarction was 0.021 +/- 0.001 compared with a mean of 0.031 +/- 0.002 mumol./0.1 ml RBC in 12 normal subjects (p less than 0.01). In five dogs injected with neuraminidase, an enzyme which removes SA from the red cell membrane, a 43% decrease in mean cardiac index from 2.3 +/- 0.22 to 1.3 +/- 0.16 (p less than 0.01) occurred. In films of the pulmonary microcircuation the mean widths of typical alveolar capillary beds decreased 42.6% +/- 5% (p less than 0.01). In three other dogs, autotransfusion with SA-depleted stored blood resulted in a 25% decrease in mean cardiac index from 2.0 +/- 0.21 to 1.5 +/- 0.21 (p less than 0.2), and a 21.7% +/- 0.9% (p less than 0.01) decrease in mean widths of typical alveolar capillary beds. We conclude that a reduction of red cell SA follows acute myocardial infarction and that SA-depleted red cells decrease cardiac index and alveolar capillary blood flow in the dogs.
D000328:Adult; D000818:Animals; D001804:Blood Transfusion, Autologous; D002196:Capillaries / Q000503:physiopathology; D002302:Cardiac Output; D004285:Dogs; D004586:Electrophoresis; D004912:Erythrocytes / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D008168:Lung / Q000098:blood supply; D008875:Middle Aged; D009203:Myocardial Infarction / Q000503:physiopathology*; D009439:Neuraminidase / Q000494:pharmacology; D012794:Sialic Acids / Q000172:deficiency*
D012794:Sialic Acids; D009439:Neuraminidase