Effects of ethyl hydrazinoacetate on gluconeogenesis and on ethanol oxidation in rat hepatocytes.
Both ethyl hydrazinoacetate and aminooxyacetate strongly inhibit gluconeogenesis from L-lactate, but not from pyruvate or fructose, in rat hepatocytes. Ethyl hydrazinoacetate partially inhibits gluconeogenesis from polyols, and also partially inhibits ethanol oxidation. In contrast to results obtained with aminooxyacetate, increasing the ethyl hydrazinoacetate concentration from 0.2 to 2 mM does not tend to diminish the inhibitory effect of this transaminase inhibitor on ethanol or polyol utilization.
D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000378:metabolism*; D005943:Gluconeogenesis / Q000187:drug effects*; D006834:Hydrazines / Q000494:pharmacology*; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats
D006834:Hydrazines; D000625:Aminooxyacetic Acid; D000431:Ethanol; C023496:ethylhydrazinoacetate