H-2d-like specificities on Gardner (H-2k) tumour detected in a restricted anti-tumour reaction.
Cytostatis of the H-2d tumour LSTRA by H-2-restricted effector lymphocytes was inhibited by antisera against H-2.4 and H-2.31 but not by antisera against public specificities or non-H-2 antigens. The unexpected reaction of the same effector cells against Gardner tumour (H-2k) was also shown to be inhibited by a combination of antisera against H-2.4 and H-2.31 but not by each antiserum used separately. The inhibitory capacity of these antisera was removed by absorption with B10.D2 but not with B10 lymphocytes. This indicated the presence of H-2d-like specificities on gardner tumour which could function as self-recognition structures in an H-2Kd and H-2Dd restricted system.
D000042:Absorption; D000818:Animals; D000912:Antibodies, Neoplasm; D002471:Cell Transformation, Neoplastic; D006183:H-2 Antigens; D007106:Immune Sera / Q000494:pharmacology; D008214:Lymphocytes / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D009374:Neoplasms, Experimental / Q000276:immunology*
D000912:Antibodies, Neoplasm; D006183:H-2 Antigens; D007106:Immune Sera