Immunization by irradiated whole cells or cell extracts against an experimental bladder tumor.
A tissue culture cell line has been developed from the MBT-2, a carcinogen induced bladder tumor of C3H/HeN mice. The culture-adapted cells retained the capacity to induce progressive tumors in syngeneic mice. Amputation-challenge experiments with live cells showed that MBT-2 induces transplantation immunity. Immunization with irradiated MBT-2 cells or hypotonic membrane preparations from this tumor protected the animals against challenge with viable MBT-2 cells. Intraperitoneal administration of bacille Calmette Guérin failed to protect against tumor development and may have adversely affected the immunoprotection yielded by tumor extracts.
D000818:Animals; D000951:Antigens, Neoplasm; D002457:Cell Extracts / Q000276:immunology; D002460:Cell Line; D002478:Cells, Cultured / Q000528:radiation effects; D005200:FANFT; D005260:Female; D006649:Histocompatibility Antigens; D007114:Immunization; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000276:immunology / Q000517:prevention & control; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000276:immunology* / Q000517:prevention & control
D000951:Antigens, Neoplasm; D002457:Cell Extracts; D006649:Histocompatibility Antigens; D005200:FANFT