[Immunological disorders in mice born after the induction of the graft versus host reaction in their mothers].
Immunological status was studied in mice born after induction of the graft-versus-host reaction in mothers. The young mice (under 1 month of age) exhibited lymphopenia, prolonged allogeneic skin graft survival, increased susceptibility to infection with typhoid bacteria, decreased number of plaque-forming cells in the spleen after immunization of mice with sheep red blood cells and Vi-antigen. In 2- to 3-month-old mice the analogous changes in immunity and reduced number of T lymphocytes in the spleen and lymph nodes were seen only in those which developed signs of runt-disease. In old mice immunity to sheep erythrocytes and number of T lymphocytes were reduced; however, responses to Vi-antigen were elevated significantly. Most of old-aged mice had high levels of the serum immunoglobulins and transferrins. In some cases positive antiglobulin tests were revealed.
D000818:Animals; D005260:Female; D006087:Graft vs Host Reaction; D007154:Immune System Diseases / Q000151:congenital* / Q000276:immunology; D007111:Immunity, Cellular; D007114:Immunization; D008198:Lymph Nodes / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011247:Pregnancy; D013154:Spleen / Q000276:immunology
Immunologicheskie narusheniia u mysheĭ, rodivshikhsia posle induktsii reaktsii transplantat protiv khoziaina u matereĭ.