title: Aryl hydrocarbon hydroxylase is inhibited by antibody to rat liver cytochrome P-450.
abstract: Antibody to the major purified cytochrome P-450 induced by 3-methylcholanthrene in rat liver strongly inhibits aryl hydrocarbon hydroxylase activity of uninduced and benz[a]anthracene-induced human monocytes and lymphocytes. Antibody to the cytochrome P-450 induced by phenobarbital has relatively little or no effect on the aryl hydrocarbon hydroxylase activity of the same human cells.
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions; D001189:Aryl Hydrocarbon Hydroxylases / Q000037:antagonists & inhibitors* / Q000276:immunology; D001551:Benz(a)Anthracenes / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000276:immunology*; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology*; D008748:Methylcholanthrene / Q000494:pharmacology; D009000:Monocytes / Q000201:enzymology*; D010424:Pentobarbital / Q000494:pharmacology; D051381:Rats
chemical_list: D001551:Benz(a)Anthracenes; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; D010424:Pentobarbital