Differential effects of benztropine and desipramine on the high affinity uptake of paratyramine in slices of the caudate nucleus and hypothalamus.
The effect of benzotropine and desipramine on the uptake of dopamine and p-tyramine was studied in slices of caudate and hypothalamus. In the hypothalamus, of the various combinations of drugs and amines, desipramine inhibited p-tyramine uptake most effectively. In the caudate, benzotropine inhibited dopamine uptake most effectively. It is suggested that in the caudate, p-tyramine may possess its own unique transport system distinct from that utilized by dopamine which is inhibited by benzotropine.
D000818:Animals; D001590:Benztropine / Q000494:pharmacology*; D001692:Biological Transport; D002421:Caudate Nucleus / Q000187:drug effects* / Q000378:metabolism; D003891:Desipramine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D051381:Rats; D014326:Tropanes / Q000494:pharmacology*; D014439:Tyramine / Q000378:metabolism*
D014326:Tropanes; D001590:Benztropine; D003891:Desipramine; D004298:Dopamine; D014439:Tyramine