Cadmium-induced reduction of bone alkaline phosphatase and its prevention by zinc.
The dietary exposure of rats to cadmium (75 ppm) for periods of up to 48 weeks caused an accumulation of cadmium in the femur, and an inhibition of the accumulation of zinc in the bone. After 48 weeks of cadmium treatment, there was a decreased activity of alkaline phosphatase in the femur. This effect was prevented by a simultaneous dietary supplement of zinc (300 ppm).
D000469:Alkaline Phosphatase / Q000378:metabolism*; D000963:Antimetabolites; D001842:Bone and Bones / Q000201:enzymology / Q000378:metabolism*; D002104:Cadmium / Q000378:metabolism / Q000494:pharmacology*; D005269:Femur / Q000378:metabolism; D013997:Time Factors; D015032:Zinc / Q000378:metabolism / Q000494:pharmacology*
D000963:Antimetabolites; D002104:Cadmium; D000469:Alkaline Phosphatase; D015032:Zinc