Simultaneous 99mTc-P-butyl-IDA and 131I-rose bengal scintigraphy in neonatal jaundice.
Eight neonates with jaundice were studied simultaneously with 99mTc-p-butyl-IDA and 131I-rose bengal. Due to physical decay, 99mTc-p-butyl-IDA failed to demonstrate delayed excretion through the patent extrahepatic biliary tract in 3 of 5 patients with concomitant hepatitis; 131I-rose bengal showed small-bowel activity in all 5. Neither agent demonstrated small-bowel activity in 3 neonates with extrahepatic biliary atresia. Based on this clinical trial, 131I-rose bengal remains the radiopharmaceutical of choice for distinguishing between hepatitis and biliary atresia in these patients.
D000818:Animals; D001652:Bile Ducts / Q000002:abnormalities / Q000000981:diagnostic imaging; D003937:Diagnosis, Differential; D006505:Hepatitis / Q000150:complications / Q000000981:diagnostic imaging; D006801:Humans; D007098:Imino Acids / Q000378:metabolism; D007231:Infant, Newborn; D007421:Intestine, Small / Q000000981:diagnostic imaging; D007457:Iodine Radioisotopes / Q000378:metabolism; D007567:Jaundice, Neonatal / Q000000981:diagnostic imaging* / Q000209:etiology; D011877:Radionuclide Imaging; D012395:Rose Bengal / Q000378:metabolism; D013667:Technetium / Q000378:metabolism; D013997:Time Factors; D014018:Tissue Distribution
D007098:Imino Acids; D007457:Iodine Radioisotopes; D012395:Rose Bengal; D013667:Technetium