Hereditary spinal arachnoid cysts, distichiasis, and lymphedema.
Familial congenital spinal arachnoid cysts causing progressive paraplegia are reported in two adolescent siblings as part of a hereditary syndrome. The other features of this unusual dominantly inherited disorder include double rows of eyelashes, partial ectropion of the lower eyelids, and acquired late-onset lymphedema of the lower extremities. The siblings' mother, who had roentgenographic evidence of a similar intraspinal lesion, was free of neurological symptoms but had the other characteristic features. Surgical treatment of the arachnoid cysts improves the progressive paraplegia.
D000293:Adolescent; D000328:Adult; D001099:Arachnoid; D002648:Child; D003560:Cysts / Q000150:complications / Q000235:genetics*; D004483:Ectropion / Q000235:genetics; D005140:Eyelashes / Q000002:abnormalities; D005143:Eyelids / Q000002:abnormalities*; D005260:Female; D006801:Humans; D008209:Lymphedema / Q000235:genetics*; D008297:Male; D010264:Paraplegia / Q000209:etiology*; D013117:Spinal Cord Compression / Q000209:etiology; D013577:Syndrome