Iotroxamide--a new cholangiographic agent. Relation between plasma concentration and biliary excretion in man.
The relationship between infusion rates, plasma concentration and biliary excretion of iotroxamide were studied in 24 patients with a T-tube in situ. Plasma iotroxamide concentration was linearly related to the rate of infusion over a dose range of 0.525 to 6.3 mg/kg/min. Peak biliary concentrations and excretory rates of iotroxamide were seen when the plasma concentration was of the order of 1500 microgram/ml. The results suggest that when using a one hour infusion of iotroxamide near optimal concentrations of iodine in the bile duct can be achieved with an infusion rate of around 4 mg/kg/minute. No toxic effects were noticed from the use of this new cholangiographic agent.
D001646:Bile / Q000032:analysis*; D002758:Cholangiography / Q000379:methods*; D003287:Contrast Media / Q000008:administration & dosage / Q000009:adverse effects / Q000378:metabolism*; D004334:Drug Administration Schedule; D006801:Humans; D007458:Iodipamide / Q000031:analogs & derivatives* / Q000378:metabolism; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D013997:Time Factors
D003287:Contrast Media; C012386:meglumine iotroxinate; D007458:Iodipamide