Inhibition of Ca2+-induced noradrenaline release from central noradrenergic neurons by morphine.
Morphine inhibited the noradrenaline release from slices of rat brain cortex induced by introduction of Ca2+ ions after superfusion with Ca2+-free K+-rich solution. The degree of inhibition was inversely related to the Ca2+ concentration used for stimulation.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D003042:Cocaine / Q000494:pharmacology; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D009474:Neurons / Q000187:drug effects / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D010646:Phentolamine / Q000494:pharmacology; D051381:Rats
D009270:Naloxone; D009020:Morphine; D003042:Cocaine; D002118:Calcium; D009638:Norepinephrine; D010646:Phentolamine