Platelet-release reaction in myocardial infarction.
A study was made of the platelet-release reaction in heparinised platelet-rich plasma taken from 26 patients, of whom 22 had sustained a definite and four a possible myocardial infarction, and from 54 age-matched controls. No significant differences in reaction were observed between the two groups. Signficant differences were seen, however, between eight patients who died within a year after infarction and the controls (P less than 0.01) and the remaining 18 patients who survived (P = 0.02). These differences were abolished when sodium citrate was included in the experimental procedure. Poor prognosis was thus related to an increased platelet-release reaction after infarction.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000367:Age Factors; D000368:Aged; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D002951:Citrates / Q000494:pharmacology; D005260:Female; D006801:Humans; D006884:Hydroxybutyrate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000401:mortality; D011379:Prognosis; D012701:Serotonin / Q000097:blood; D012737:Sex Factors
D002951:Citrates; D012701:Serotonin; D000244:Adenosine Diphosphate; D006884:Hydroxybutyrate Dehydrogenase