Spontaneous cytotoxicity of murine cells treated with the interferon inducers BRL 5907 and BRL 10739.
The effects of the polyribonucleotide interferon inducers, BRL 5907 and BRL 10739, on the spontaneous cytotoxicity of CBA mouse cells towards the allogeneic lymphoma EL-4, were investigated. Intravenous administration of BRL 5907 and BRL 10739 increased the cytotoxic activity of a non-adherent, theta-negative, surface immunoglobulin-negative cell present in the spleen, but had no effect on cells in the lymph nodes. Spleen cell cytotoxicity was established within 24 h of injection of the polyribonucleotides, but had disappeared by 4 days. In addition, injection of mice with BRL 10739 increased the spontaneous cytotoxicity of a nylon-wool-adherent, theta-positive spleen cell. Intraperitoneal injection of mice with BRL 5907 and BRL 10739 also enhanced the cytotoxic activity of a non-adherent peritoneal exudate cell.
D000818:Animals; D001202:Ascitic Fluid / Q000276:immunology; D003602:Cytotoxicity, Immunologic / Q000187:drug effects*; D007369:Interferon Inducers / Q000494:pharmacology*; D008198:Lymph Nodes / Q000276:immunology; D008223:Lymphoma / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000276:immunology; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D012330:RNA, Double-Stranded / Q000494:pharmacology*; D012367:RNA, Viral / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology
D007369:Interferon Inducers; D000644:Quaternary Ammonium Compounds; D012330:RNA, Double-Stranded; D012367:RNA, Viral; C006192:BRL 5907; C006243:BRL 10739