title: Chromosomal abnormality in the newborns of hepatitis B surface antigen (HBsAg) carrier mothers.
abstract: The association of maternal hepatitis B surface antigen carriers (HBsAg) and chromosomal abnormalities in their newborns has been previously suggested. This is a report on two female infants with abnormalities of chromosome 18 and trisomy 3q syndrome who were born to HBsAg carriers. These cases indicate that a possible relationship exists between the HBsAg carrier state in the mother and chromosome abnormalities in her offspring. It is suggested that the parents of all newborns with a structural chromosomal abnormality be tested for HBsAg.
mesh_terms: D002353:Carrier State / Q000276:immunology*; D002869:Chromosome Aberrations / Q000209:etiology*; D025063:Chromosome Disorders; D002902:Chromosomes, Human, 16-18; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006510:Hepatitis B Antibodies / Q000032:analysis; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007621:Karyotyping; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology*; D014314:Trisomy
chemical_list: D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens