The late positive component of the evoked response in acute schizophrenics during a test of sustained attention.
To investigate the relationship between behavioral and cortical measures of impaired attention in schizophrenia, 17 hospitalized acute schizophrenics and 16 hospitalized nonpsychotic patients were studied. Event-related potentials (ERP) were obtained while subjects performed the Continuous Performance Test (CPT) under three conditions: First base line, Auditory-Visual Distraction, and Second base line. Schizophrenics made more errors of omission and commission and had longer reaction times. Analysis of the Late Positive Component (LPC) of the ERP revealed that both groups had an attenuated LPC during distraction and a larger LPC to the critical compared to the noncritical stimulus throughout all conditions. Schizophrenics had a smaller LPC and a smaller amplitude difference between the critical and noncritical stimulus than the nonpsychotics throughout all conditions.
D000293:Adolescent; D000328:Adult; D001288:Attention / Q000187:drug effects / Q000502:physiology*; D001307:Auditory Perception / Q000502:physiology; D002540:Cerebral Cortex / Q000503:physiopathology*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D011619:Psychotropic Drugs / Q000627:therapeutic use; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D012559:Schizophrenia / Q000188:drug therapy / Q000503:physiopathology*; D014796:Visual Perception / Q000502:physiology
D011619:Psychotropic Drugs