title: Effect of butylated hydroxytoluene on Newcastle disease virus.
abstract: A study was done to examine the effects of butylated hydroxytoluene (BHT) on purified Newcastle disease virus (NDV). Treatment of the virus with 50 microgram of BHT/ml caused 92% inactivation of the virion infectivity. Virion adsorption to chicken-embryonated cells was inhibited 32% and synthesis of intracellular hemagglutinin was inhibited 29%. Electron microscopy of the BHT-treated virions revealed virion envelope damage. Chicken-embryonated cells treated with 25 microgram of BHT/ml before NDV infection demonstrated 65% inhibition of NDV progeny production.
mesh_terms: D002084:Butylated Hydroxytoluene / Q000494:pharmacology*; D002478:Cells, Cultured; D009522:Newcastle disease virus / Q000187:drug effects* / Q000254:growth & development / Q000648:ultrastructure
chemical_list: D002084:Butylated Hydroxytoluene