title: Synthesis of 8-methoxy-15,16-dinor-6,8,10-trichothecatriene 12,13 alpha-epoxide and 12,13 beta-epoxide as potential antineoplastic agents.
abstract: 8-Methoxy-15,16-dinor-6,8,10-trichothecatriene 12,13 alpha-epoxide (5) and 12,13 beta-epoxide (3) were prepared; the stereochemistry of the epoxides was assigned on the basis of 13C NMR. The epoxide 5 was active against 9KB in vitro and P388 in vivo, while the isomeric epoxide 3 was inactive in both test systems.
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D002478:Cells, Cultured; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D009303:Nasopharyngeal Neoplasms; D012717:Sesquiterpenes; D014255:Trichothecenes
chemical_list: D000970:Antineoplastic Agents; D012717:Sesquiterpenes; D014255:Trichothecenes