The structural relatedness of the virus core proteins of Rauscher and Moloney murine leukaemia virus.
The virus core proteins p30, p15, pp12 and p10 of Rauscher (R-MuLV) and Moloney murine leukaemia virus (Mo-MuLV) were purified. Two-dimensional peptide maps of 3H-leucine-containing tryptic peptides as well as elution profiles from ion-exchange chromatography of tryptic peptides derived from 3H-tyrosine-labelled R-MuLV core proteins and 14C-tyrosine-labelled Mo-MuLV core proteins were compared. The results show that the p30 and p10 proteins are very similar but that p15 and pp12 exhibit significant differences.
D000818:Animals; D002478:Cells, Cultured; D005591:Chemical Fractionation; D055598:Chemical Phenomena; D002621:Chemistry; D002852:Chromatography, Ion Exchange; D004591:Electrophoresis, Polyacrylamide Gel; D007930:Leucine / Q000302:isolation & purification; D051379:Mice; D008979:Moloney murine leukemia virus / Q000032:analysis* / Q000378:metabolism; D010455:Peptides / Q000032:analysis; D011925:Rauscher Virus / Q000032:analysis* / Q000378:metabolism; D014443:Tyrosine / Q000302:isolation & purification; D014764:Viral Proteins
D010455:Peptides; D014764:Viral Proteins; D014443:Tyrosine; D007930:Leucine