Evidence for a vesicular transport mechanism in hepatocytes for biliary secretion of immunoglobulin A.
Quantitative electron microscopic autoradiography and diaminobenzidine cytochemistry provide evidence for an uptake and vesicular transport mechanism for iodine-125-labeled immunoglobulin A from plasma to bile by hepatocytes in vivo. The data confirm the existence of a hepatobiliary pathway for secretion of immunoglobulin A into the intestine and are consistent with a vesicular transport mechanism for biliary proteins within liver parenchymal cells.
D000818:Animals; D001345:Autoradiography; D001646:Bile / Q000276:immunology*; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D007070:Immunoglobulin A / Q000378:metabolism*; D007071:Immunoglobulin A, Secretory / Q000378:metabolism*; D008099:Liver / Q000276:immunology / Q000378:metabolism*; D008297:Male; D009940:Organoids / Q000378:metabolism; D051381:Rats; D012635:Secretory Component / Q000378:metabolism
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D012635:Secretory Component