Transient pure red-cell aplasia: cell-mediated suppression of erythropoiesis associated with hepatitis.
Transient pure red-cell aplasia is a rare complication of persistent acute hepatitis. We have investigated possible mechanisms for marrow suppression in one such patient who developed erythroid aplasia in the course of transfusion-related hepatitis. The patient's lymphocytes, obtained during the acute illness, markedly inhibited erythroid colony formation by donor marrow. After the patient recovered, remission lymphocytes in co-culture did not inhibit colony formation. No reversible suppression was demonstrable by addition of patient serum. These observations suggest that hematocytopenias associated with hepatitis may result from cell-mediated suppression induced by hepatic injury.
D000368:Aged; D000741:Anemia, Aplastic / Q000150:complications* / Q000276:immunology; D001853:Bone Marrow / Q000276:immunology; D004920:Erythropoiesis; D006509:Hepatitis B / Q000097:blood / Q000150:complications* / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular; D008214:Lymphocytes / Q000276:immunology; D008297:Male