title: Importance of the lactonic ring in the activity of steroidal antialdosterones.
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D002191:Canrenoic Acid / Q000494:pharmacology; D002192:Canrenone / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D000451:Mineralocorticoid Receptor Antagonists; D011188:Potassium / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013148:Spironolactone / Q000494:pharmacology; D013256:Steroids / Q000494:pharmacology*
chemical_list: D007783:Lactones; D000451:Mineralocorticoid Receptor Antagonists; D013256:Steroids; D013148:Spironolactone; D002192:Canrenone; D002191:Canrenoic Acid; D012964:Sodium; D011188:Potassium