Effect of perphenazine on secretory patterns of growth hormone in the rat.
A nonstressfull frequent sampling technique was employed to determine the effect of perphenazine, 5 mg/kg on spontaneous secretion of rat growth hormone (rGH). The drug blocked secretion almost entirely for at least 3, but no more than 22 h. These results suggest a role for dopamine and/or norepinephrine as stimulatory neurotransmitters for spontaneous rGH secretory episodes. The further suggest that experimental or therapeutic use of phenothiazines might produce functional GH deficiency.
D000818:Animals; D002940:Circadian Rhythm; D013006:Growth Hormone / Q000378:metabolism*; D008297:Male; D010546:Perphenazine / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D013006:Growth Hormone; D010546:Perphenazine