title: Hyperthermic peritoneal perfusion system in canines.
abstract: The thermal infusion filtration system was designed to manage malignant effusions and treat metastatic cancers of the intracavitary serosa. Hyperthermia, chemotherapy, and cell and debris filtration were administered by a dynamic fluid flow. Preclinical evaluations of surgical procedure, temperature studies, fluid dynamics, and physiology were carried out in 15 dogs (17.2 to 25.4 kg) with peritoneal perfusion at 41 degrees C and 10 liters/hr flow. Results suggest that the dynamics of flow achieves total intracavitary equilibrium in 7 min. The time essential to elevate animal body mass temperature from ambient to 41 degrees varied as a function of mass. The hyperthermia induced expected nonlethal responses in physiology. The system was determined to be safe for clinical procedure.
mesh_terms: D000818:Animals; D001833:Body Temperature Regulation; D001835:Body Weight; D004285:Dogs; D005260:Female; D006358:Hot Temperature / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000628:therapy; D010477:Perfusion / Q000009:adverse effects / Q000379:methods*; D010529:Peritoneal Cavity; D013997:Time Factors