Seed extracts inhibiting protein synthesis in vitro.
Of 33 seed extracts examined, 12 inhibited protein synthesis in a rabbit reticulocyte lysate. This activity seems to be due to a protein, since (i) it was recovered with the (NH4)2SO4 precipitate, (ii) it was retained by dialysis membranes, and (iii) in all cases but one was destroyed by boiling. Only the extracts from the seeds of Adenia digitata and, to a lower extent, of Euonymus europaeus inhibited protein synthesis in intact cells.
D000818:Animals; D000963:Antimetabolites / Q000494:pharmacology*; D003864:Depression, Chemical; D010940:Plant Proteins / Q000032:analysis / Q000494:pharmacology*; D014176:Protein Biosynthesis; D011506:Proteins / Q000037:antagonists & inhibitors*; D011817:Rabbits; D012156:Reticulocytes / Q000187:drug effects / Q000378:metabolism; D012639:Seeds / Q000032:analysis*
D000963:Antimetabolites; D010940:Plant Proteins; D011506:Proteins