title: Influence of diet on the acyl composition of phospholipids in endothelial cells and mitochondria of rat brain.
abstract: The effect of diet on phospholipid acyl groups of rat brain endothelial cells and mitochondria and of liver was determined. Rats were fed high-protein diets with a 4:1 linoleate/linolenate ratio but with 4.4%, 1.9%, or 0.8% of the caloric content provided by these essential fatty acids (cal % EFA) or were fed a fat-free diet. In capillary endothelial cells the greatest change occurred in the plasmalogen ethanolamine fraction, there being a significant reduction in the n-3 series of acyl groups and increase in the n-9 series as the cal % EFA was reduced. Other phospholipid fractions changed little. More pronounced changes occurred in brain mitochondria and liver phospholipids. The small changes in capillary endothelia with cal % EFA are in contrast to the great changes produced by a change in the linoleate/linolenate ratio. As the ratio is reduced, there is a progressive increase in the n-3 series in all phospholipid fractions.
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D004041:Dietary Fats / Q000008:administration & dosage / Q000494:pharmacology*; D004727:Endothelium / Q000032:analysis; D004983:Ethanolamines / Q000032:analysis; D005228:Fatty Acids, Essential / Q000172:deficiency; D005260:Female; D008041:Linoleic Acids / Q000008:administration & dosage; D008042:Linolenic Acids / Q000008:administration & dosage; D051379:Mice; D008928:Mitochondria / Q000032:analysis; D008930:Mitochondria, Liver / Q000032:analysis / Q000187:drug effects; D010743:Phospholipids / Q000032:analysis*; D010955:Plasmalogens / Q000032:analysis; D011247:Pregnancy; D051381:Rats
chemical_list: D004041:Dietary Fats; D004983:Ethanolamines; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D008042:Linolenic Acids; D010743:Phospholipids; D010955:Plasmalogens