[Haemolytic anaemia with acanthocytosis and erythrocytic glutathione peroxidase deficiency in severe hepatic diseases. 5 cases (author's transl)].
In 5 patients, haemolysis was intrasplenic. Red cell deformity could be acquired by foreign red cells transfused into the patient. Association of the two abnormalities (acanthocytosis and glutathion peroxydase deficiency) was necessary for the onset of haemolysis. They progressed in parallel and varied in relation with the severity of the hepatic disease. The relationship between these two abnormalities is unknown but would appear to be dependent upon a factor of hepatic origin.
D000050:Acanthocytes / Q000473:pathology*; D000328:Adult; D000743:Anemia, Hemolytic / Q000201:enzymology / Q000209:etiology*; D004912:Erythrocytes / Q000201:enzymology; D004913:Erythrocytes, Abnormal / Q000473:pathology*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood / Q000172:deficiency*; D006461:Hemolysis; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications* / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010544:Peroxidases / Q000172:deficiency*
D010544:Peroxidases; D005979:Glutathione Peroxidase
Anémie hémolytique avec acanthocytose et déficit en glutathion peroxydase érythrocytaire au cours des hépatopathies alcooliques sévères. 5 observations.