I.V. practolol during microlaryngoscopy. Effect on arterial pressure, heart rate, blood glucose and lipolysis.
Twenty-five patients undergoing microlaryngoscopy were anaesthetized with thiopentone and nitrous oxide with suxamethonium as a muscle relaxant. Thirteen received practolol 0.4 mg kg-1 and atropine 1.5 mg i.v. shortly before anaesthesia. During anaesthesia practolol 0.2 mg kg-1 was given. Twelve (control) received atropine 0.5 mg before anaesthesia. Practolol reduced the frequency of tachycardia and arrhythmia. The treatment group had a greater reduction in systolic arterial pressure during induction. The hypertensive response to laryngoscopy was not significantly attenuated by practolol. A weak hyperglycaemic response to microlaryngoscopy was not affected, nor was the plasma concentration of glycerol.
D000368:Aged; D000768:Anesthesia, General; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D005990:Glycerol / Q000097:blood; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D007432:Intraoperative Period; D007828:Laryngoscopy; D008297:Male; D008866:Microsurgery; D008875:Middle Aged; D011217:Practolol / Q000008:administration & dosage / Q000494:pharmacology*
D001786:Blood Glucose; D005990:Glycerol; D011217:Practolol