Activation of polycyclic aromatic hydrocarbons to mutagens by singlet oxygen: an enhancing effect of atmospheric pollutants?
Chrysene and 3-methylcholanthrene are transformed to direct-acting mutagens by photodynamically generated singlet oxygen. In view of the presence of this species of oxygen in the polluted atmosphere, the possible conversion of environmental polycyclic aromatic hydrocarbons to mutagens and to potential direct-acting ('ultimate') carcinogens deserves consideration.
D002274:Carcinogens, Environmental; D002911:Chrysenes / Q000494:pharmacology; D004785:Environmental Pollutants; D008748:Methylcholanthrene / Q000494:pharmacology; D009153:Mutagens; D010100:Oxygen; D010616:Phenanthrenes; D010777:Photochemistry; D012475:Salmonella / Q000187:drug effects
D002274:Carcinogens, Environmental; D002911:Chrysenes; D004785:Environmental Pollutants; D009153:Mutagens; D010616:Phenanthrenes; D008748:Methylcholanthrene; D010100:Oxygen