Isocratic multi-column high-performance liquid chromatography as a technique for qualitative analysis and its application to the characterisation of basic drugs using an aqueous methanol solvent.
A variety of high-performance liquid chromatography packing materials were prepared and their chromatographic properties compared for separating several basic drugs using a single solvent system. The three most promising packing materials (silica, a mercapto propyl modified silica and a n-propyl sulphonic acid modification) were subsequently used to provide retention volume data for a large number of drugs.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006863:Hydrogen-Ion Concentration; D000432:Methanol; D004364:Pharmaceutical Preparations / Q000032:analysis*; D012997:Solvents; D013329:Structure-Activity Relationship
D004364:Pharmaceutical Preparations; D012997:Solvents; D000432:Methanol