title: Placental transfer and neonatal effects of diazepam when administered to women just before delivery.
abstract: Diazepam 10 mg i.v. was administered to 23 patients (test group) just before delivery. The umbilical cord blood was analysed for diazepam and the well-being of neonates in the test group and in a suitable control group (n = 32) was compared using analysis of covariance. Diazepam was detected in neonatal blood about 0.5 min following its administration to mothers. No significant differences in neonatal well-being were detected between the two groups. However, a highly significant inverse relationship was found between the rectal temperature of the newborn and the concentration of diazepam in umbilical cord blood.
mesh_terms: D000328:Adult; D001831:Body Temperature / Q000187:drug effects*; D003975:Diazepam / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D005260:Female; D005312:Fetal Blood / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007743:Labor, Obstetric; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013997:Time Factors
chemical_list: D003975:Diazepam