title: Circular dichroism studies of keto-bile acids.
abstract: Circular dichroism curves for various saturated bile acid derivatives with carbonyl groups at carbon atoms 3,7, and 12 are presented and it is demonstrated that this method offers a convenient solution for the location of mono and diketo carbonyl groups in the bile acid molecule. From the shapes (n leads to II transition) of these CD curves the precise localization of the carbonyl groups and the stereochemistry of the A/B ring juncture can be determined.
mesh_terms: D001647:Bile Acids and Salts / Q000138:chemical synthesis; D002942:Circular Dichroism; D007651:Keto Acids / Q000138:chemical synthesis; D008968:Molecular Conformation; D013329:Structure-Activity Relationship
chemical_list: D001647:Bile Acids and Salts; D007651:Keto Acids