Inhibition of sterol biosynthesis by 14 alpha-hydroxy-delta 7-sterols.
5 alpha-Cholest-7-en-3 beta, 14 alpha-diol and 5 alpha-cholest-7-en-14 alpha-ol-3-one have been found to be potent inhibitors of the synthesis of digitonin-precipitable sterols in L cells in culture and to reduce the levels of HMG-CoA reductase activity in these cells.
D000818:Animals; D002782:Cholestenes / Q000494:pharmacology*; D002783:Cholestenones / Q000494:pharmacology*; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007739:L Cells / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D013261:Sterols / Q000096:biosynthesis*
C024011:5 alpha-cholest-7-en-14 alpha-ol-3-one; D002782:Cholestenes; D002783:Cholestenones; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D013261:Sterols; C024010:cholest-7-en-3,14-diol