Erythropoietic effects of PGE2 and 2 endoperoxide analogs.
The erythropoietic effects in exhypoxic polycythemic mice of two endoperoxide and analogs were assessed and compared with PGE2. The 9 alpha, 11 alpha epoxymethano analog (U-44069) was found to be a much more potent erythropoietic stimulus than the 11 alpha, 9 alpha analog (U-46619) or PGE2.
D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D004920:Erythropoiesis / Q000187:drug effects*; D005260:Female; D007501:Iron / Q000097:blood; D051379:Mice; D008815:Mice, Inbred Strains; D011449:Prostaglandin Endoperoxides / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology*
D011449:Prostaglandin Endoperoxides; D011458:Prostaglandins E; D007501:Iron