[Epithelial bladder tumor induction in rats with N-(4-(5-nitro-2-furyl)-2-thiazolyl)formamide].
Among 20 white non-inbred rats of the "Rappolovo" nursery for laboratory animals of the USSR Academy of Medical Sciences, which were fed through all their life N-/4-(5-nitro-2-furyl)-2-thiazolyl/formamide in the concentration 0.188%, transition-cell vesical tumors developed in 4 animals at the 56th, 60th, 61st 70th week of the experiment. After 71--81 weeks since the onset of the experiment, cancer of this organ developed in the remaining 14 animals. The maximum total dose of the carcinogen was 14.4 g/ per rat. The maximum observation terms--567 days.
D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000139:chemically induced; D005200:FANFT / Q000009:adverse effects*; D005559:Formamides / Q000009:adverse effects*; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D010212:Papilloma / Q000139:chemically induced; D051381:Rats; D013844:Thiazoles / Q000009:adverse effects*; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D005559:Formamides; D013844:Thiazoles; D005200:FANFT
Induktsiia éitelial'nykh opukholeĭ mochevogo puzyria u krys N-(4-(5-nitro-2-furil)-2-tiazolil) formamidom.