Vesicle targeting: timed release and specificity for leukocytes in mice by subcutaneous injection.
When unilamellar vesicles were administered subcutaneously in mice, the half-time for the destruction of the vesicles varied from 12 to 600 hours, depending on their composition. The vesicles tested consisted of distearoyl phosphatidylcholine, cholesterol, and certain sugar and amino-sugar derivatives of cholesterol. Vesicle with amino-sugar derivatives showed the greatest longevity and became localized with high specificity in aggregates of polymorphonuclear leukocytes. A substantial delay between the time that the vesicles broke open and the time that labels contained in the vesicles were excreted suggests that the vesicles undergo endocytosis before destruction.
D000818:Animals; D002784:Cholesterol / Q000031:analogs & derivatives; D004705:Endocytosis; D008081:Liposomes / Q000627:therapeutic use*; D008247:Lysosomes / Q000378:metabolism; D008657:Metabolic Clearance Rate; D051379:Mice; D009504:Neutrophils / Q000378:metabolism*; D010713:Phosphatidylcholines; D013329:Structure-Activity Relationship
D008081:Liposomes; D010713:Phosphatidylcholines; D002784:Cholesterol