[Leukocyte sensitization to tumor and embryonic antigens in gastric cancer and peptic ulcer].
The antigens (AG) of gastric cancer extracts would inhibit the migration of leucocytes in the culture with control serum in 6 among 7 (85%) patients with gastric cancer (GC) of stage I, in 8 of 10 (80%) patients -- stage II, in 24 of 43 (56%) patients-stage III, in 10 of 35 (28.5%) patients -- stage IV. The effect of autoplasma on the inhibition of leucocytes migration (ILM) of GC AG was varied. The mixture of extracts from several tumors suppressed more frequently the migration of leucocytes. The liver extracts antigens of a 10-week human embryo induced ILM in 29 of 49 (59%) patients with GC I--IV. The gastric mucosa antigens induced ILM in 21 of 95 (22%) patients GC I--IV. The migration of leucocytes in 13 of 110 (12%) control patients was suppressed by AG GC in the culture containing control serum. AG of human embryo liver induced ILM in 7 of 55 (13%) examined control patients, 5 of them having ulcerous disease. It is supposed that sensitization to embryonal antigens may procede malignant transformation of gastric ulcers.
D000328:Adult; D000368:Aged; D000941:Antigens / Q000276:immunology*; D000951:Antigens, Neoplasm / Q000276:immunology*; D002464:Cell Migration Inhibition; D004381:Duodenal Ulcer / Q000276:immunology; D004622:Embryo, Mammalian / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007114:Immunization; D007962:Leukocytes / Q000276:immunology*; D008099:Liver / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000276:immunology*; D013276:Stomach Ulcer / Q000276:immunology*
D000941:Antigens; D000951:Antigens, Neoplasm
O sensibilizatsii leĭkotsitov k opukholevym i émbrional'nym antigenam u bol'nykh rakom i iazvennoi bolezn'iu zheludka.