title: Ultrastructure of the human enamel organ. II. Internal enamel epithelium, preameloblasts, and secretory ameloblasts.
abstract: The fine structure of internal enamel epithelium, preameloblasts and secretory ameloblasts in primary tooth germs (bell stage) from four human foetuses was investigated. The characteristics of the differentiation of internal enamel epithelium via preameloblasts to secretory ameloblasts are described. The internal enamel epithelium consists of a row of low differentiated prismatic cells separated from the dental papilla by a distinct even basal lamina. In the preameloblasts the rough endoplasmic reticulum cisterns and mitochondria increase in number, the Golgi complexes become extensive and take up a distal position, and secretory granules are formed. Furthermore, the basal lamina is removed by coated vesicles, and proximally and distally in the cells a complex of zonulae adhaerentes, terminal webs and gap junctions is formed. The secretory ameloblasts make up a layer of highly differentiated cells demonstrating typical merocrine secretion.
mesh_terms: D000565:Ameloblasts / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004658:Enamel Organ / Q000196:embryology / Q000648:ultrastructure*; D004848:Epithelium / Q000648:ultrastructure; D006003:Glycogen / Q000032:analysis; D006056:Golgi Apparatus / Q000648:ultrastructure; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure; D009804:Odontoblasts / Q000648:ultrastructure; D009940:Organoids / Q000648:ultrastructure; D014083:Tooth Germ / Q000648:ultrastructure*
chemical_list: D006003:Glycogen