Electrophysiological evidence for motor unit impairment during the treatment of leprosy.
Although neuropathy is the most striking feature in leprosy, the effects of various drugs are usually assessed by dermatological and bacteriological improvement. This short term electrophysiological study shows that both antileprosy drugs, DDS and Sulforthomidine, do not affect the insidious deterioration of motor unit condition in lepromatous and borderline BT patients. Differences observed in the results of the two groups were discussed.
D003622:Dapsone / Q000627:therapeutic use*; D006801:Humans; D007918:Leprosy / Q000188:drug therapy* / Q000503:physiopathology; D009045:Motor Endplate / Q000187:drug effects / Q000503:physiopathology*; D009431:Neural Conduction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000503:physiopathology*; D010543:Peroneal Nerve / Q000187:drug effects / Q000503:physiopathology; D011999:Recruitment, Neurophysiological / Q000187:drug effects; D013413:Sulfadoxine / Q000627:therapeutic use*; D013424:Sulfanilamides / Q000627:therapeutic use*; D014459:Ulnar Nerve / Q000187:drug effects / Q000503:physiopathology
D013424:Sulfanilamides; D013413:Sulfadoxine; D003622:Dapsone