Prostaglandin-like substances in Propionibacterium acnes. IV. Effect on isolated human vessels.
The present study demonstrates a powerful vasoconstrictor activity of prostaglandin-like substances (PLS), extracted from P. acnes, on human blood vessels. PLS is about equipotent to PGE2 in its effect on human umbilical vessels, but the contractile response pattern is different. PLS therefore seems to have specific and different physiological characteristics.
D001681:Biological Assay; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011247:Pregnancy; D011424:Propionibacterium / Q000032:analysis*; D011453:Prostaglandins / Q000302:isolation & purification* / Q000494:pharmacology; D011458:Prostaglandins E / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D014469:Umbilical Arteries / Q000187:drug effects
D011453:Prostaglandins; D011458:Prostaglandins E; D012701:Serotonin