title: Protective effect of hyaluronidase after long-term aortic cross-clamping: initial experimental observations.
abstract: This work studies the effect of hyaluronidase on myocardium subjected to long-term aortic cross-clamping (three hours) and moderate hypothermia (28 degrees C). Animals receiving hyaluronidase (1,00o U per liter) through the root of the aorta with a procaine-potassium chloride-lasmalyte cardioplegic solution showed better functional, electrical, and morphological response than the untreated animals. These findings, although preliminary, appear to be promising for potential clinical application.
mesh_terms: D000818:Animals; D002315:Cardiopulmonary Bypass; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006821:Hyaluronoglucosaminidase / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000473:pathology
chemical_list: D006821:Hyaluronoglucosaminidase