In vitro pregnenolone metabolism by mouse adrenal gland: I-estrogen synthesis.
Adrenal gland homogenates from four different strains of mice were incubated with (4-14C)-pregnenolone and a NADPH generating system. Although quantitative differences between high and low mammary tumor strains occured, all mice synthesized estrone. The highest aromatase activity was found 2 months after castration of the (C3H x RIII) F1 mice when castration was performed at 4 days of age; this activity was lower in the C3H mice and almost negligible in the RIII and C57BL mice.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D002369:Castration; D004958:Estradiol / Q000031:analogs & derivatives / Q000378:metabolism; D004967:Estrogens / Q000096:biosynthesis*; D004970:Estrone / Q000378:metabolism; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D011284:Pregnenolone / Q000378:metabolism*; D013045:Species Specificity; D013997:Time Factors
D004967:Estrogens; C025004:estradiol-17 beta-3-methyl ether; D004970:Estrone; D004958:Estradiol; D011284:Pregnenolone