[Action of free fatty acids on platelet aggregation induced with thrombin].
The sinergic effect on thrombin-induced platelet aggregation by Free Fatty Acids (FFA) was studied "in vitro". Our results showed that "sub-critical" concentrations of long carbon chains of saturated and unsaturated FFA potentiated the platelet aggregation induced by "critical" concentration of thrombin. However, we suggest that: a) exogenous long carbon chains of FFA could enhance the platelet membrane lipids and increase the ciclic Endoperoxides, Prostaglandins and Thromboxan A2 synthesis; b) exogenous long carbon chains of FFA could induce the platelets more "sensitive" to aggregating effect of "critical" concentrations of thrombin.
D005230:Fatty Acids, Nonesterified / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D013917:Thrombin / Q000494:pharmacology*
D005230:Fatty Acids, Nonesterified; D013917:Thrombin
Azione degli acidi grassi liberi sull'aggregazione piastrinica indotta da trombina.