title: Distribution and tissue dose of intraperitoneally administered radioactive chromic phosphate (32P) in New Zealand white rabbits.
abstract: Radiophosphorus (32P) has become the preferred radioisotope for intraperitoneal radiotherapy in the adjuvant treatment of ovarian cancer. In a study of the distribution and tissue dose of intraperitoneally administered 32P in rabbits, effective half-lives of 32P and the radiation dose absorbed by intra-abdominal tissues were determined. Results show that 32P is not uniformly distributed over the peritoneal surfaces and that many areas are minimally irradiated. It is concluded that a significant fraction of the 32P distribution is systemic and that the beta-ray dose for intra-abdominal tissues is much lower than suggested by theoretical models.
mesh_terms: D000818:Animals; D001345:Autoradiography; D002857:Chromium / Q000627:therapeutic use; D005260:Female; D007274:Injections, Intraperitoneal; D008954:Models, Biological; D010051:Ovarian Neoplasms / Q000378:metabolism / Q000532:radiotherapy*; D010537:Peritoneum / Q000378:metabolism; D010710:Phosphates / Q000378:metabolism* / Q000627:therapeutic use; D010761:Phosphorus Radioisotopes / Q000378:metabolism* / Q000627:therapeutic use; D011817:Rabbits; D011879:Radiotherapy Dosage; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D010710:Phosphates; D010761:Phosphorus Radioisotopes; D002857:Chromium