title: [Effect of amphoglucamine on humoral immunity indices].
abstract: It was shown that amphoglucamine, a new Soviet polyenic antibiotic had no significant effect on the antibody titers in the reactions of agglutination, complement binding and precipitation, when administered at various periods of immunogenesis of rabbits immunized with killed C. immitis vaccine. No signific and difference in the serum complement titers of the immunized animals was found. The study on the protective properties of the immunized animal sera demonstrated that the antibiotic administered during immunogenesis rather inhibited the preventive properties of the immune sera. Amphoglucamine administered during immunogenesis suppressed intracutaneous allergic reactions to the antigen. The data should be considered in the diagnostic practice, since some times the allergic reactions are the only diagnostic sign.
mesh_terms: D000284:Administration, Oral; D000372:Agglutination Tests; D000666:Amphotericin B / Q000031:analogs & derivatives* / Q000276:immunology; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D003045:Coccidioides / Q000276:immunology; D003168:Complement Fixation Tests; D005657:Fungal Vaccines / Q000008:administration & dosage; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D007114:Immunization; D011233:Precipitin Tests; D011817:Rabbits; D013997:Time Factors
chemical_list: D005657:Fungal Vaccines; C023999:amphoglucamine; D000666:Amphotericin B
vernacular_title: Vliianie amfogliukamina na nekotorye pokazateli gumoral'nogo immuniteta.