Absorption and excretion of metronidazole after administration of metronidazole benzoate mixture.
Serum concentrations and urinary excretion of metronidazole after single dose therapy were investigated in patients with giardiasis. A metronidazole benzoate mixture was administered to 10 adults in total doses of 2 g and to 6 children in doses of approximately 50 mg/kg body weight. No unhydrolyzed metronidazole benzoate was found in the serum. The maximum serum concentrations of metronidazole averaged 30 microgram/ml. These values as well as estimated metronidazole absorption were approximately 30% lower than in 3 adult patients given single doses of 2 g of pure metronidazole in tablet form.
D000328:Adult; D002648:Child; D002675:Child, Preschool; D005260:Female; D005873:Giardiasis / Q000188:drug therapy; D006801:Humans; D007223:Infant; D008297:Male; D008795:Metronidazole / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D008875:Middle Aged
D008795:Metronidazole