title: Relapsing eosinophilic perimyositis.
abstract: Two patients with a syndrome of relapsing myalgia are described. In both cases nonspecific inflammatory features were present and electromyography disclosed a myositic pattern in one. Muscle biopsy in both patients showed a perimysial infiltrate of eosinophils although peripheral eosinophilia was only noted in one patient. In each, relapse occurred after a recovery phase, but eventually recovery was complete, spontaneously in one, and after therapy in the other. The known causes of eosinophilic myositis are reviewed, with emphasis on a companion with the myositis of eosinophilic fascitis (Shulman's syndrome). Because our cases exhibited distinctive features, this new syndrome should be considered in the differential diagnosis of any eosinophilic myositis.
mesh_terms: D000328:Adult; D004804:Eosinophils; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009220:Myositis / Q000097:blood / Q000188:drug therapy / Q000473:pathology*; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D011239:Prednisolone; D007213:Indomethacin