Laboratory evaluation of heparin therapy.
Plasma heparin levels measured using several different methods showed a wide variation in results. In particular an anti-factor Xa clotting technique gave very much higher results than thrombin clotting time and partial thromboplastin time techniques. This was less marked when a synthetic chromogenic substrate assay was used. Possible reasons for these observations and their relevance in the selection of therapeutic ranges are discussed.
D000328:Adult; D001792:Blood Platelets / Q000032:analysis / Q000187:drug effects; D005069:Evaluation Studies as Topic; D005170:Factor X / Q000032:analysis / Q000276:immunology; D006493:Heparin / Q000097:blood / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D010314:Partial Thromboplastin Time; D013918:Thrombin Time
D005170:Factor X; D006493:Heparin