Effects of morphine on cortex, hippocampus and medial thalamus: a comparison between urethane-anaesthetized and paralyzed-awake rats.
Urethane is often used as a central anaesthetic in neurophysiological studies of drug effects. In this experiment, the effect of morphine on cortical EEG and single units of hippocampus and medial thalamus were compared in urethane-anaesthetized and paralyzed-awake rats. In each case, there was evidence of a morphine-urethane interaction, suggesting caution in the interpretation of drug studies using urethane-anaesthetized animals.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects*; D009020:Morphine / Q000494:pharmacology*; D051381:Rats; D013390:Succinylcholine / Q000494:pharmacology*; D013788:Thalamus / Q000187:drug effects*; D014520:Urethane / Q000494:pharmacology*
D014520:Urethane; D009020:Morphine; D013390:Succinylcholine