title: Phenylfurans IV: spasmolytic 3-diethylamino-2,2-(dimethyl)propyl esters of 5-substituted phenyl-2-furancarboxylic acids.
abstract: A series of 3-diethylamino-2,2-(dimethyl)propyl 5-substituted phenyl-2-furancarboxylates was prepared and found to be pharmacologically active in vitro as GI tract nonanticholinergic smooth muscle spasmolytic agents. One of the more active compounds in the series contained the 5-(4-nitrophenyl) group.
mesh_terms: D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005663:Furans / Q000138:chemical synthesis*; D007082:Ileum / Q000187:drug effects; D010276:Parasympatholytics / Q000138:chemical synthesis* / Q000494:pharmacology; D011817:Rabbits
chemical_list: D005663:Furans; D010276:Parasympatholytics