[Toxicity and radioprotective properties of 3,4,5,6-tetrahydropyrimidine and 3,6-dihydropyrimidine derivatives].
Acute toxicity and radioprotective properties of 16 derivatives of tetrahydro- and dihydropyrimidines were studied in experiments on mice. Hydroiodides of 4,6,6-trimethyl-3,R-2-methylthio-3,6-dihydropyrimidines were shown to be more toxic than respective hydroiodides of 4,6,6-trimethyl-3-R-2-methylthio-4-oxy-3,4,5,6-tetrahydropyrimidines. Four compounds exhibited moderate radioprotective properties.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D005720:Gamma Rays; D007928:Lethal Dose 50; D051379:Mice; D011743:Pyrimidines / Q000633:toxicity*; D011829:Radiation Dosage; D011837:Radiation-Protective Agents; D013329:Structure-Activity Relationship; D013997:Time Factors
D011743:Pyrimidines; D011837:Radiation-Protective Agents
Toksichnost' i radiozaschitnye svoĭstva nekotorykh proizvodnykh 3,4,5,6-tetragidropirimidinov i 3,6-digidropirimidinov.