[Toxicological properties of fentirin].
Phentyrin toxicity depends to a large measure on the route of its administration. Adequately toxic doses of phentyrin intravenously are approximately ten times as less compared to peroral administration. High doses of the drug produce appetite loss, occasional vomiting, salivation, diarrhea, flabbiness and weight loss. ECG shows slow pulse, reduced voltage and changes in T wave. At early periods the animals' death ensues with phenomena of emaciation, a delayed death can be recorded only in some cases. Morbid anatomy shows atrophic changes in the lymphatic nodes, in the spleen, thyroid, in the gastrointestinal mucosa, and changes in the liver and kidneys. Phentyrin in tolerated doses exerts no adverse action on stem cells of bone marrow, but affects spleen cells. The drug alters the weight of some endocrine organs -- the thyroid, uterus and adrenals.
D000818:Animals; D001769:Blood / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D007928:Lethal Dose 50; D051379:Mice; D009588:Nitrogen Mustard Compounds / Q000494:pharmacology / Q000633:toxicity*; D011817:Rabbits; D051381:Rats; D012119:Respiration / Q000187:drug effects; D012996:Solutions; D013607:Tablets; D013997:Time Factors; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity
D009588:Nitrogen Mustard Compounds; D012996:Solutions; D013607:Tablets; D014443:Tyrosine; C014745:phentyrin
Toksikologicheskie svoĭstva fentirina.