Determination of plasma mepindolol levels by high-performance liquid chromatography and electrochemical detection.
A method for determining the plasma concentration of the beta-receptor blocking agent mepindolol by high-performance liquid column chromatography (paired-ion chromatography) and electrochemical detection is described. Pindolol is used as an internal standard and the detection limit after extraction of 1 ml of plasma is less than 1 ng of mepindolol. Reproducible results can be obtained with relative standard deviations from replicate analyses of 5 ng/ml plasma samples within +/- 4.7%. The method is also suitable for quantification of plasma pindolol levels with mepindolol as an internal standard.
D000328:Adult; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005260:Female; D006801:Humans; D008875:Middle Aged; D010869:Pindolol / Q000031:analogs & derivatives* / Q000097:blood
C015340:mepindolol; D010869:Pindolol