Spontaneous reversal of ethinyl estradiol-induced cholestasis in the rat.
The spontaneous reversal ethinyl estradiol-induced cholestasis has been documented 7 days after the last estrogen administration in the rat. This finding supports the hypothesis that estrogens produce only a transient functional failure of the hepatocytic structures responsible for bile secretion.
D000818:Animals; D001646:Bile / Q000187:drug effects / Q000378:metabolism; D002779:Cholestasis / Q000139:chemically induced / Q000503:physiopathology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D051381:Rats
D004997:Ethinyl Estradiol