title: [Specific complex formation study of human immunoglobulins of various classes with their antibodies].
abstract: The process of specific complex formation of different human immunoglobulines M, G and A with IgG antibody against them was investigated by the thermistor method. It was shown that the rate and intensity of the process vary with the types of interacting immunoglobulines, and that they reach maximum for IgM. From the character of the curves obtained a judgement can be formed about the immunoglobulin type being synthesized at the given moment. Disturbance of the inner structure of immunoglobulin macromolecules, e.g. during heating, leads to changes in the mechanism of complex formation, it being important what particular component underwent denaturation.
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D000936:Antigen-Antibody Complex; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D007075:Immunoglobulin M / Q000276:immunology*; D046911:Macromolecular Substances; D008970:Molecular Weight; D011817:Rabbits; D013696:Temperature
chemical_list: D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D046911:Macromolecular Substances
vernacular_title: Izuchenie spetsificheskogo komplesoobrazovaniia chelovecheskikh immunoglobulinov raznykh klassov s antitelami protiv nikh.