[Animal test for evaluation of ototoxicity and safety of KW-1062 (author's transl)].
KW-1062, a new aminoglycoside antibiotic, was tested for the evaluation of audiotoxicity in administration at higher dosage and compared with the audiotoxicity of gentamicin. KW-1062 was given at dosage of 50, 100 and 150 mg/kg intramuscularly for 4 weeks to each group consisting of 10 healthy guinea pigs, respectively. Gentamicin was administered at dosage of 25, 35, 50 and 100 mg/kg in the same way as in KW-1062 to the guinea pigs. In the present study the differential frequency pinna reflex test in the frequency range from 20 kHz to 0.5 kHz was performed before and during administration of the drugs, to evaluate the audiotoxicity. Comparison of number of animal with pinna reflex loss and extent of frequency range of pinna reflex loss revealed that KW-1062 at dose of 150 mg/kg is less audiotoxic than gentamicin at 50 mg/kg and 100 mg/kg, and approximately equivalent in audiotoxicity to gentamicin at dose of 35 mg/kg.
D000617:Aminoglycosides; D000818:Animals; D000900:Anti-Bacterial Agents; D004305:Dose-Response Relationship, Drug; D005839:Gentamicins / Q000008:administration & dosage / Q000633:toxicity*; D006168:Guinea Pigs; D012022:Reflex, Acoustic / Q000187:drug effects*
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D005839:Gentamicins; C037545:micronomicin