Decreased phalloidin response, phallotoxin uptake and bile acid transport in hepatocytes prepared from wistar rats treated chronically with diethylnitrosamine.
Isolated hepatocytes prepared from rats pretreated with diethylnitrosamine (0.5 mg/kg DENA/DAY P.O.) are less sensitive to phalloidin poisoning. They take up lower amounts of both phallotoxins and bile acids than controls. The degree of inhibition depends on the period of pretreatment.
D000546:Amanitins / Q000378:metabolism*; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism*; D003864:Depression, Chemical; D004052:Diethylnitrosamine / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism*; D008297:Male; D009602:Nitrosamines / Q000494:pharmacology*; D009842:Oligopeptides / Q000037:antagonists & inhibitors*; D010590:Phalloidine / Q000037:antagonists & inhibitors* / Q000506:poisoning; D051381:Rats
D000546:Amanitins; D001647:Bile Acids and Salts; D009602:Nitrosamines; D009842:Oligopeptides; D010590:Phalloidine; D004052:Diethylnitrosamine; C018358:phallotoxin