Physical and dissolution characteristics and bio-availability of five brands of digoxin tablets.
Five brands of digoxin were investigated and compared for physical and dissolution characteristics and bio-availability. The dissolution characteristics, which are regarded as a measure of bio-availability in the case of digoxin, were investigated with a spectrofluorimeter. Significant differences were found among the five brands. Only one brand met all the various criteria that were investigated.
D001682:Biological Availability; D004077:Digoxin / Q000378:metabolism* / Q000592:standards; D007408:Intestinal Absorption; D012995:Solubility; D013607:Tablets / Q000592:standards*; D013678:Technology, Pharmaceutical
D013607:Tablets; D004077:Digoxin