title: Calcification by proteolipid from atherosclerotic aorta.
abstract: Calcified atherosclerotic aorta was examined for proteolipid capable of nucleating apatite, the crystal species of aortic calcification. Appropriate tissue pieces were decalcified with dilute formic acid and extracted with chloroform-methanol. Lipid fractionation yielded proteolipid which, upon incubation in metastable calcium phosphate solution, induced apatite crystallization. The proteolipid was partially characterized as a hydrophobic protein, acidic phospholipid complex. It resembles the nucleator previously demonstrated for bone matrix calcification.
mesh_terms: D001011:Aorta / Q000032:analysis*; D001031:Apatites; D001161:Arteriosclerosis / Q000378:metabolism*; D002114:Calcinosis / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D003460:Crystallization; D006801:Humans; D011510:Proteolipids / Q000032:analysis* / Q000378:metabolism
chemical_list: D001031:Apatites; D011510:Proteolipids; D002118:Calcium