Results with tamoxifen in advanced mammary carcinoma.
The results of a study with tamoxifen (TAM) (10 mg three times daily) in advanced breast cancer are reported. Of 44 patients, 24 showed a remission and 20 a progression. Of the 17 patients in whom an oestrogen receptor (ER) determination in tumour tissue had been carried out, 12 were receptor-positive (ER+) and five receptor-negative (ER-). Nine of the 12 ER+ cases (75%) responded to the treatment with TAM. Of the five ER- patients, one showed remission and four progression.
D001859:Bone Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000032:analysis / Q000188:drug therapy*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008593:Menopause; D009362:Neoplasm Metastasis; D011960:Receptors, Estrogen / Q000032:analysis; D012075:Remission, Spontaneous; D013629:Tamoxifen / Q000008:administration & dosage*
D011960:Receptors, Estrogen; D013629:Tamoxifen