DOCA administration increases renal phospholipase activity in the rat.
The phospholipase activity of renal tissue has been evaluated in controls and in DOCA treated rats. DOCA treated animal showed a higher than normal enzyme activity. Since a phospholipase is the key step in prostaglandin biosynthesis, it is suggested that the increased prostaglandin release promoted by mineraloactive steroids is mediated by an activation of this key enzyme.
D000818:Animals; D003900:Desoxycorticosterone / Q000494:pharmacology*; D007668:Kidney / Q000201:enzymology*; D008297:Male; D010740:Phospholipases / Q000378:metabolism*; D051381:Rats; D013268:Stimulation, Chemical
D003900:Desoxycorticosterone; D010740:Phospholipases