title: Inhibition of candidacidal activity of human neutrophil leukocytes by aminoglycoside antibiotics.
abstract: We have tested the effect of five aminoglycoside antibiotics (gentamicin, sisomicin, tobramycin, ribostamycin, and amikacin) on the candidacidal activity of human neutrophils in vitro; all of them are inhibitory and can be grouped into three significantly different levels of toxicity. Gentamicin in the most toxic and sisomicin is the least toxic.
mesh_terms: D000583:Amikacin / Q000494:pharmacology; D000617:Aminoglycosides / Q000009:adverse effects / Q000494:pharmacology*; D002175:Candida / Q000276:immunology*; D005839:Gentamicins / Q000494:pharmacology; D006801:Humans; D009504:Neutrophils / Q000187:drug effects* / Q000502:physiology; D012271:Ribostamycin / Q000494:pharmacology; D012853:Sisomicin / Q000494:pharmacology; D014031:Tobramycin / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D005839:Gentamicins; D012271:Ribostamycin; D000583:Amikacin; D014031:Tobramycin; D012853:Sisomicin