Surface activities of barbital, phenobarbital, and pentobarbital and their interaction energies with phospholipid monolayers.
The adsorption free energies of barbital, phenobarbital, and pentobarbital at the air-water interface were estimated from plots of the surface pressure (pi less than or equal to 5 dynes/cm) against the bulk concentration. Their energies of interaction with dipalmitoylphosphatidylethanolamine and dipalmitoyllecithin monolayers spread at the air-water interface were estimated from the surface pressure increase with increasing concentrations of the subphase-injected barbituric acid derivatives. Adsorption free energies and interaction energies were barbital less than phenobarbital less than pentobarbital, which correlate with their nerve blocking concentration.
D001462:Barbital; D001463:Barbiturates; D055598:Chemical Phenomena; D002621:Chemistry; D008563:Membrane Lipids; D010424:Pentobarbital; D010634:Phenobarbital; D010743:Phospholipids; D013499:Surface Properties
D001463:Barbiturates; D008563:Membrane Lipids; D010743:Phospholipids; D001462:Barbital; D010424:Pentobarbital; D010634:Phenobarbital