title: Relationship between X chromosome activation, Barr body frequency and oestrogen receptor status in human breast cancer: a hypothesis.
abstract: Current evidence indicates an association between oestrogens, sex chromatin frequency and X chromosome activation in relation to the activity of the enzyme glucose-6-phosphate dehydrogenase. We suggest that a similar association might apply to control the level of oestradiol receptors in breast tumours and present information supporting this hypothesis.
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000378:metabolism; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006801:Humans; D009376:Neoplasms, Hormone-Dependent / Q000235:genetics* / Q000378:metabolism; D011960:Receptors, Estrogen; D012728:Sex Chromatin; D012730:Sex Chromosomes; D014960:X Chromosome
chemical_list: D011960:Receptors, Estrogen; D005954:Glucosephosphate Dehydrogenase