[Intrahepatic circulation of 14C-phenazepam and its metabolites in albino rats].
Excretion of phenazepam and its metabolites into the bile and their intrahepatic circulation were studied in experiments on rats, bile donors, who were preliminarily injected 14C-phenazepam (14 mg/kg) intravenously and on recipients who were administered the donor's bile intraduodenally. It was shown that phenazepam (compound I) and its 3-hydroxymetabolite (compound III) are excreted into the bile of the animals. Hydroxyl derivatives are excreted with the bile as glucuronides. Compounds I and III and glucuronide III undergo intrahepatic circulation.
D000818:Animals; D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D001570:Benzodiazepinones / Q000378:metabolism*; D001646:Bile / Q000502:physiology; D005965:Glucuronates / Q000378:metabolism; D007700:Kinetics; D008102:Liver Circulation; D008297:Male; D051381:Rats
D014151:Anti-Anxiety Agents; D001570:Benzodiazepinones; D005965:Glucuronates; D001569:Benzodiazepines; C017928:phenazepam
Vnutripechenochnaia tsirkuliatsiia 14-B-fenazepama i ego metabolitov v organizme belykh krys.