[The serum levels of estradiol-17 beta and progesterone following hyper-stimulation of the ovaries by clomiphen].
The serum levels of estradiol-17 beta and progesterone in a cycle which was hyperstimulated by Clomiphen are reported. The pre-ovulatory maximum of estradiol-17-beta was 3,240 pg/ml, the maximum during the luteal phase was 2,930 pg/ml. The increase of progesterone to 54.8 ng/ml during the luteal phase was an indication of multiple ovulation. Bilateral ovarian enlargement was palpated. At the same dosage in the following menstrual cycle the maximum pre-ovulatory estradiol-17-beta was 962 pg/ml and the maximum progesterone in the luteal phase was 9.1 ng/ml. During this second cycle the ovaries were not palpably enlarged. It is concluded that sensitivity of the ovaries to hyper-stimulation by Clomiphen may vary from menstrual cycle to menstrual cycle. A single hyperstimulation does not necessarily indicate further hyperstimulation in subsequent cycles.
D000328:Adult; D002996:Clomiphene / Q000494:pharmacology*; D004958:Estradiol / Q000097:blood*; D005260:Female; D006801:Humans; D008183:Luteal Phase; D010049:Ovarian Diseases / Q000175:diagnosis; D010060:Ovulation; D011374:Progesterone / Q000097:blood*; D013268:Stimulation, Chemical
D002996:Clomiphene; D011374:Progesterone; D004958:Estradiol
Serumkonzentrationsverhalten von Ostradiol-17 beta and Progesteron bei durch Clomiphen überstimulierten Ovarien.