Rhabdomyolysis during treatment with epsilon-aminocaproic acid.
Severe rhabdomyolysis and acute renal failure occurred in a patient receiving epsilon-aminocaproic acid. The lack of evidence of vascular involvement in the muscle biopsy specimen suggests that epsilon-aminocaproic acid may have direct myotoxicity. This drug may produce a spectrum of muscle disease from mild myopathy to life-threatening rhabdomyolysis.
D000328:Adult; D000614:Aminocaproates / Q000009:adverse effects*; D015119:Aminocaproic Acid / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D009132:Muscles / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced* / Q000473:pathology; D009212:Myoglobinuria / Q000139:chemically induced*; D009336:Necrosis; D013345:Subarachnoid Hemorrhage / Q000188:drug therapy
D000614:Aminocaproates; D015119:Aminocaproic Acid