title: Mitochondrial creatine kinase. A poor prognostic sign.
abstract: A serum creatine kinase (CK) isoenzyme band cathodic to MM, thought to represent mitochondrial CK, was found in eight patients in shock, six of whom died within 12 days. Severe tissue damage appears to be required to release this isoenzyme to detectable levels in the serum.
mesh_terms: D000328:Adult; D000368:Aged; D001219:Aspartate Aminotransferases / Q000378:metabolism; D004796:Clinical Enzyme Tests; D003402:Creatine Kinase / Q000378:metabolism*; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D006327:Heart Block / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008928:Mitochondria / Q000201:enzymology*; D008929:Mitochondria, Heart / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D008931:Mitochondria, Muscle / Q000201:enzymology; D011379:Prognosis; D012770:Shock, Cardiogenic / Q000201:enzymology*
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D003402:Creatine Kinase