title: 99mTc-methyl-CCNU for the static imaging of kidneys.
abstract: A new radiopharmaceutical, 99mTc-Methyl-CCNU, was prepared for the static imaging of kidneys and the radiochemical purity was tested by paper and thin-layer chromatography. The biological distribution was studied in 15 mice sacrificed at 10 min. 30 min, 1 h, 3 h, and 6 h after IV injection. Blood clearance and excretion of the agent in urine were followed in three volunteers for a period of 24 h. Renal uptake was high (25% in 6 h), plasma clearance very fast (90% in 1 h), and urinary excretion reached a platueau after 6 h with 25% excretion. A longitudinal slice of a rabbit kidney showed the cortical accumulation on autoradiography and scintigraphy. Clinical studies indicated the usefulness of this radiopharmaceutical as a kidney imaging agent.
mesh_terms: D000818:Animals; D006801:Humans; D007668:Kidney / Q000000981:diagnostic imaging*; D007672:Kidney Cortex / Q000000981:diagnostic imaging; D007674:Kidney Diseases / Q000000981:diagnostic imaging; D051379:Mice; D009607:Nitrosourea Compounds; D011817:Rabbits; D011829:Radiation Dosage; D011877:Radionuclide Imaging; D012673:Semustine / Q000378:metabolism; D013667:Technetium; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D009607:Nitrosourea Compounds; D012673:Semustine; D013667:Technetium