title: [Immunosuppressive action and effects of amethopterin on the lymphoid tissue of the rabbit appendix].
abstract: Effects of amethopterin (MTX) on lymphoid tissue of rabbit appendix have been evaluated. The drug caused an evident depletion of lymphoid cells. This finding suggested the relevance of cytotoxicity in the mechanism of immune suppression. Discontinuation of drug treatment demonstrated a tendency toward the reorganization of the lymphoid tissue.
mesh_terms: D000818:Animals; D001065:Appendix / Q000187:drug effects* / Q000276:immunology; D005260:Female; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D008221:Lymphoid Tissue / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008727:Methotrexate / Q000494:pharmacology*; D011817:Rabbits
chemical_list: D007166:Immunosuppressive Agents; D008727:Methotrexate
vernacular_title: Azione immunosoppressiva ed effetti dell'ametopterina sul tessuto linfoide dell'appendice nel coniglio.