[Hemopoietic action of the high-molecular fraction of leukocytic pyrogen].
During fractionation of the rabbit leukocytic pyrogen (LP) on Sephadex column and by the ethanol method, the apyrogenic protein fraction was isolated. In intact rats this fraction induced granulocytopoiesis stimulation: a rise in granulocyte proliferative activity, an increase in total granulocyte count in the bone marrow and peripheral blood, and also a rise in the number of macrocolonies in the spleen of lethally irradiated mice due to an increase in granulocyte colonies.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004247:DNA / Q000096:biosynthesis; D006410:Hematopoiesis / Q000187:drug effects*; D007958:Leukocyte Count; D007962:Leukocytes / Q000032:analysis*; D051379:Mice; D008970:Molecular Weight; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013154:Spleen / Q000187:drug effects
D011749:Pyrogens; D004247:DNA
Gemopoéticheskoe deĭstvie vysokomolekuliarnoĭ fraktsii leĭkotsitarnogo pirogena.