The effectiveness of clonidine as an antihypertensive in a two-dose regimen.
The therapeutic efficacy of clonidine as an antihypertensive in a b.i.d. schedule 150--300 micrograms daily was evaluated. The blood pressure reduction in patients with essential hypertension was satisfactory on this regimen and the steady-state plasma concentrations were within the BP-lowering concentration range at the end of a dosage interval.
D000328:Adult; D001794:Blood Pressure; D003000:Clonidine / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D003000:Clonidine