[Effect of verapamil (isoptin) on kidney function].
In experiments on conscious dogs intravenous administration of verapamil (3-4 mg/kg) reduced diuresis, natriuresis and glomerular filtration. After that the filtration returned to normal and diuresis and natriuresis increased. Following infusion into the renal artery verapamil enhanced diuresis and natriuresis because of the inhibition of tubular reabsorption. In rats verapamil (5-10 mg/kg) also induced a rise in diuresis and sodium excretion, but water diuresis is reduced at first.
D000818:Animals; D003404:Creatinine / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D004326:Drinking / Q000187:drug effects; D007668:Kidney / Q000187:drug effects*; D009318:Natriuresis / Q000187:drug effects; D011188:Potassium / Q000652:urine; D051381:Rats; D012964:Sodium / Q000652:urine; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology*
D012964:Sodium; D003404:Creatinine; D014700:Verapamil; D011188:Potassium
Vliianie verapamila (izoptina) na funktsiiu pochek.