Parkinson disease, dementia, and Alzheimer disease: clinicopathological correlations.
Clinical records and neuropathological specimens from 36 patients with autopsy-demonstrated idiopathic Parkinson disease (PD) were reviewed independently and the results compared. Nine (31%) of the 29 patients with adequate clinical data had severe dementia and 7 (24%) had mild dementia. The cerebral cortex showed senile plaques and fibrillary tangles in 15 of the 36 patients (42%). These changes were found in all 9 patients with severe dementia, in 3 of the 7 with mild dementia, and in 3 of the 13 patients with normal mental status. The prevalence of pathologically established Alzheimer changes and dementia among the patients with PD (33%) was over six times that found in an age-matched population (5.1%). Survival after the onset of PD with Alzheimer disease was shorter than in PD without Alzheimer disease.
D000367:Age Factors; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology*; D003704:Dementia / Q000150:complications*; D005260:Female; D006624:Hippocampus / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000150:complications* / Q000401:mortality / Q000473:pathology; D010300:Parkinson Disease / Q000150:complications* / Q000401:mortality / Q000473:pathology