Effect of peripheral blood mononuclear cells from aplastic anemia patients on the granulocyte-macrophage and erythroid colony formation in samples from normal human bone marrow in vitro--a cooperative work.
Thirty-six patients with aplastic anemia and three with aplastic anemia-PNH syndrome in eight institutes were studied for the presence of peripheral blood mononuclear cells having a suppressive effect on granulocyte-macrophage (G-M) and erythroid colony formation using a uniform protocol. In 11 cases of 29 (38%) and 9 cases of 29 (31%), the presence of mononuclear cells with a suppressive effect on G-M and erythroid colony formation, respectively, was demonstrated. However, the presence of mononuclear cells suppressive both to G-M and erythroid colony formation was demonstrated only in 3 of 19 cases (16%).
D000293:Adolescent; D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000097:blood*; D001854:Bone Marrow Cells; D002648:Child; D002675:Child, Preschool; D003114:Colony-Forming Units Assay; D004912:Erythrocytes; D005260:Female; D006098:Granulocytes; D006457:Hemoglobinuria, Paroxysmal / Q000097:blood; D006801:Humans; D008264:Macrophages; D008297:Male; D008875:Middle Aged; D010586:Phagocytes; D012075:Remission, Spontaneous; D013577:Syndrome