FR-31564, a new phosphonic acid antibiotic: bacterial resistance and membrane permeability.
Mutants which acquired resistance to FR-31564 were also resistant to fosfomycin and vice versa. Some exceptions to cross-resistance were found among clinical isolates of certain species. FR-31564 was found to be incorporated into bacterial cells more efficiently than fosfomycin although the extent of incorporation varied among species. In particular, the uptake rate of FR-31564 by a strain of Pseudomonas aeruginosa was ten times that of fosfomycin. The uptake rate of FR-31564 by both FR-31564- and fosfomycin-resistant mutants was less than one-tenth of that by the parent strain. FR-31564 was scarcely inactivated in the culture broths of FR-31564-resistant strains. All of the FR-31564-resistant mutants of P. aeruginosa came under the classification of strains lacking an L-alpha-glycerophosphate transport system.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects* / Q000378:metabolism; D050260:Carbohydrate Metabolism; D002463:Cell Membrane Permeability; D004352:Drug Resistance, Microbial; D004355:Drug Stability; D005578:Fosfomycin / Q000031:analogs & derivatives / Q000378:metabolism / Q000494:pharmacology*; D009154:Mutation
D000900:Anti-Bacterial Agents; D005578:Fosfomycin; C024640:fosmidomycin