Preliminary clinical experience with dezocine, a new potent analgesic.
The analgesic effect of a single intravenous dose of dezocine at various dosage levels was studied in 41 patients suffering from acute renal colic. Twenty milligrams was found to be a very effective dose. Out of 25 injections an excellent response was recorded on 21 occasions, with a mean duration of effect of 3.5 hours. In a further 3 patients, pain relief was considered as fair and of shorter duration. Pronounced dizziness was a nearly constant side-effect of the drug. There was no overall effect on blood pressure or heart rate.
D000700:Analgesics / Q000008:administration & dosage* / Q000009:adverse effects* / Q000627:therapeutic use; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D003085:Colic / Q000188:drug therapy*; D003516:Cycloparaffins / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004244:Dizziness / Q000139:chemically induced; D006801:Humans; D007674:Kidney Diseases / Q000188:drug therapy*; D013764:Tetrahydronaphthalenes
D000700:Analgesics; D019086:Bridged Bicyclo Compounds, Heterocyclic; D001952:Bridged-Ring Compounds; D003516:Cycloparaffins; D013764:Tetrahydronaphthalenes; C010827:dezocine