[Antitumor activity of the serum and lymphocytes of C57BL mice in chemical carcinogenesis].
In chemical carcinogenesis induced by methylcholanthrene in mice C57BL the antitumor activity of sera ind lymphocytes are studied, which was assessed by their capacity to inhibit-stimulate spheroid formation by autologous tumor cells. The serum of animals being at the initial stage of the blastomatous process is found to inhibit the formation of spheroids but to reduce the functional activity of lymphocytes, while in the terminal stage of blastoma growth it contributes to the enhancement of tumor growth under direct interaction with cell-targets or indirectly through lymphocytes.
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D006168:Guinea Pigs; D007116:Immunization, Passive; D008198:Lymph Nodes / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology*; D008748:Methylcholanthrene; D051379:Mice; D008810:Mice, Inbred C57BL / Q000276:immunology*; D012513:Sarcoma, Experimental / Q000139:chemically induced / Q000276:immunology / Q000628:therapy*
D008748:Methylcholanthrene
Protivoopukholevaia aktivnost' syvorotki i limfotsitov mysheĭ C57BL pri khimicheskom kantserogeneze.