["In vitro" susceptibility of some aerobic and anaerobic bacteria to three 5-nitro-imidazole derivatives: metronidazole, ornidazole and tinidazole (author's transl)].
As shown earlier, the three drugs are effective against most anaerobic bacteria. However, with Bacteroides fragilis the geometric mean MIC of metronidazole (0.43 microgram/ml), ornidazole (0.37 microgram/ml) and tinidazole (0.20 microgram/ml) are statistically different. Moreover, and contrary to generally accepted opinion, some aerobic bacteria such as Moraxella and Bacillus can be susceptible to nitro-imidazoles. The results suggest another mechanism for the action of nitro-imidazoles, different from that previously described. This underscores the major role of the reduction of the nitrogroup by a low-redox-potential. Two strains of strictly anaerobic bacteria show a relative resistance in the microaerophilic zone.
D000332:Aerobiosis; D000693:Anaerobiosis; D001419:Bacteria / Q000187:drug effects*; D004352:Drug Resistance, Microbial; D008795:Metronidazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009593:Nitroimidazoles / Q000494:pharmacology*; D009950:Ornidazole / Q000494:pharmacology*; D010100:Oxygen / Q000494:pharmacology; D010313:Partial Pressure; D014011:Tinidazole / Q000494:pharmacology*
D009593:Nitroimidazoles; D014011:Tinidazole; D008795:Metronidazole; D009950:Ornidazole; D010100:Oxygen
Sensibilité comparée in vitro de quelques bactéries aérobies et anaérobies à trois dérivés des 5-nitro-imidazoles: le métronidazole, l'ornidazole et le tinidazole.