title: In vitro studies on the duration of action of dihydroergotamine.
abstract: Changes in tension were monitored isometrically on spiral strips from canine saphenous and femoral veins. Dihydroergotamine elicited an increase in tension at threshold concentrations (about 0.1 ng/ml) which are in accordance with mean plasma levels found in vivo after single oral doses in dog and man. In addition, it was demonstrated that the dihydroergotamine-induced venoconstriction persisted for several hours even when the drug was eliminated from the bathing solution.
mesh_terms: D000818:Animals; D004087:Dihydroergotamine / Q000097:blood / Q000494:pharmacology*; D004285:Dogs; D005260:Female; D005268:Femoral Vein / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000037:antagonists & inhibitors; D012039:Regional Blood Flow / Q000187:drug effects; D012501:Saphenous Vein / Q000187:drug effects; D013997:Time Factors; D014662:Vasoconstrictor Agents
chemical_list: D014662:Vasoconstrictor Agents; D004087:Dihydroergotamine; D009638:Norepinephrine