Assessment of renal concentrating ability in lithium-treated patients. Comparison of long-term dehydration with administration of a vasopressin analogue.
In patients given long-term treatment with lithium maximum urine osmolality was measured after 26 h of dehydration and after intranasal administration of desamino-8-D-arginine vasopressin (DDAVP). A high correlation was found between the results of the two tests suggesting that the DDAVP test is a suitable method of assessing renal concentrating ability in lithium-treated patients.
D000281:Administration, Intranasal; D000328:Adult; D001127:Arginine Vasopressin; D004231:Diuresis / Q000187:drug effects*; D005260:Female; D006801:Humans; D007671:Kidney Concentrating Ability / Q000187:drug effects*; D008094:Lithium / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D013894:Thirst; D013997:Time Factors; D014556:Urine
D001127:Arginine Vasopressin; D008094:Lithium