Studies on cardioactive steroids. IV. Influence of nitrate ester formation on cardiac and extracardiac activity.
The effects of 19 nitrate esters of genins and glycosides on the isolated guinea pig atrium and ileum were studied. The positive inotropic effect of glycoside nitrates correlated with the contracting effect on the ileum. Genin nitrates with weak cardiac activity were found to exert smooth muscle relaxing effects. Compared to genin nitrates, glyceryl trinitrate had a weaker relaxing effect on the ileum. On the coronary strip it had a stronger effect than delta 14-anhydrodigitoxigenin-3 beta-mononitrate, the most effective smooth muscle relaxing genin nitrate.
D000818:Animals; D002301:Cardiac Glycosides / Q000494:pharmacology*; D003331:Coronary Vessels / Q000187:drug effects; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D009566:Nitrates / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D002301:Cardiac Glycosides; D009566:Nitrates