HLA, atopy, and cyclophosphamide in steroid-responsive childhood nephrotic syndrome.
In a study designed to confirm our preliminary report of associations between HLA-B12, atopy, and relapse following cyclophosphamide treatment in steroid-responsive nephrotic syndrome (SRNS), we again found a higher incidence of HLA-B12 in SRNS children (44%) than we did in controls (24%). The association of HLA-B12 with short time-to-relapse after cyclophosphamide treatment of SRNS was also confirmed, but that with atopy in SRNS children was not, though we observed a similarly high incidence of atopy in them as before.
D001249:Asthma / Q000276:immunology; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use*; D004485:Eczema / Q000276:immunology; D006680:HLA Antigens; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000378:metabolism; D009404:Nephrotic Syndrome / Q000188:drug therapy* / Q000276:immunology; D012008:Recurrence; D006255:Rhinitis, Allergic, Seasonal / Q000276:immunology; D012882:Skin Tests; D013997:Time Factors
D006680:HLA Antigens; D007073:Immunoglobulin E; D003520:Cyclophosphamide