The distribution of apo C-II and apo C-III in very low density lipoproteins of normal and type IV subjects.
The apoC-II/apoC-III ratio and the distribution of C apoproteins as percentage of the total protein in VLDL obtained from normolipidemic and type IV patients was studied by analytical isoelectrofocusing. While the percentage concentration of apoCI-III was unchanged that of apoC-II was 9.2% of total protein in normal VLDL and only 7.4% in type IV VLDL (P less than 0.05). The apoC-II/apo C-III ratio significantly decreased in type IV patients. The analysis of VLDL subfractions obtained by density gradient ultracentrifugation gave essentially the same results. These data confirm the decrease of apoC-II as % of the protein in type IV VLDL and suggest that the decrease of the apoC-II/apoC-iii ratio in type IV patients is related only to the decreased content of apoC-II. Whether the reduced apoC-II percentage amount or the decreased apoC-II/apo C-III ratio are related to the hypertriglyceridemia in type IV subjects is still unclear.
D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001053:Apolipoproteins / Q000032:analysis*; D001056:Apolipoproteins C; D006801:Humans; D006953:Hyperlipoproteinemia Type IV / Q000097:blood*; D007525:Isoelectric Focusing; D008079:Lipoproteins, VLDL / Q000032:analysis*; D008297:Male
D053304:Apolipoprotein C-II; D053305:Apolipoprotein C-III; D001053:Apolipoproteins; D001056:Apolipoproteins C; D008079:Lipoproteins, VLDL