[Immunological tolerance and antituberculosis immunity].
Marked tuberculosis immunity and resistance to tuberculous infection during infecting with virulent culture of mycobacteria H(37)Rv were studied in experimental immunologic tolerance indiced in CBA mice by administering a large dose of the polyantigen BCG and the immunodepressant cyclophosphane. After BCG vaccination the tolerant animals do not develop tuberculosis cellular immunity (in accordance to blast transformation and skin tuberculin tests), with the protective effect of vaccination not brought up in a group of tolerant mice.
D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage; D003520:Cyclophosphamide / Q000008:administration & dosage; D007108:Immune Tolerance / Q000187:drug effects; D007109:Immunity / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D013997:Time Factors; D014376:Tuberculosis / Q000276:immunology*
D001500:BCG Vaccine; D003520:Cyclophosphamide
Immunologicheskaia tolerantmost' i protivotuberkuleznyĭ immunitet.