6-Methylcoumarin photocontact dermatitis.
Sporadic cases of a severe photocontact dermatitis have appeared in the last few years following use of fruity-smelling suntan preparations and sunlight exposure. We report five such cases in women who developed severe edema and erythema of sun-exposed areas shortly after application of agents containing 6-methylcoumarin used as fragance. Routine photopatch testing was unproductive in reproducing the reaction, but immediate application of 6-methylcoumarin before ultraviolet A (UVA) radiation elicited significant positive results.
D000328:Adult; D003374:Coumarins / Q000009:adverse effects*; D004487:Edema / Q000139:chemically induced; D004890:Erythema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D010328:Patch Tests; D010787:Photosensitivity Disorders / Q000139:chemically induced*; D013473:Sunscreening Agents / Q000009:adverse effects*; D014466:Ultraviolet Rays
D003374:Coumarins; D013473:Sunscreening Agents; C018096:6-methylcoumarin