The role of methionine and vitamin B12 in folate incorporation by rat liver.
The decreased folate uptake induced by exposure of rats to nitrous oxide can be partly reversed by methionine supplementation. This is consistent with the theory that N2O inhibits methylcobalamin-dependent methionine synthetase (EC 2.1.1.13) in rat liver and previous observations showing decreased folate incorporation in rats made nutritionally vitamin B12 deficient.
D000818:Animals; D005492:Folic Acid / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008715:Methionine / Q000494:pharmacology / Q000502:physiology*; D009609:Nitrous Oxide; D051381:Rats; D014805:Vitamin B 12 / Q000502:physiology*; D014806:Vitamin B 12 Deficiency / Q000139:chemically induced / Q000378:metabolism
D005492:Folic Acid; D008715:Methionine; D009609:Nitrous Oxide; D014805:Vitamin B 12