A comparison of pregnancy experience in DES-exposed and DES-unexposed daughters.
Reproductive histories were compared for 226 DES-exposed and 203 -unexposed daughters whose mothers participated in a double-blind evaluation 27 years before. Irregular menstruation was slightly more common among the exposed (10%) than among the unexposed (4%). Nineteen of the exposed and only four of the unexposed had primary infertility. Among those at risk, 86% of the unexposed and 67% of the exposed had become pregnant. The reasons for these differences are not known. Comparison of evaluable first pregnancy outcome revealed full-term live birth to be more common among the unexposed (85%) than the exposed (47%). Premature live birth was experienced by 22% of the exposed but only 7% of the unexposed. Nonviable outcomes of stillbirth, neonatal death, miscarriage and ectopic pregnancy occurred in 31% of the exposed and 8% of the unexposed. The difference in pregnancy outcomes between the groups is highly significant. The DES-exposed with transverse cervicovaginal ridges were more likely to experience a nonviable outcome. Overall 82% of the exposed and 93% of the unexposed had at least one live offspring.
D000022:Abortion, Spontaneous / Q000139:chemically induced; D000328:Adult; D002584:Cervix Uteri / Q000187:drug effects; D004054:Diethylstilbestrol / Q000009:adverse effects / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007247:Infertility, Female / Q000139:chemically induced; D008431:Maternal-Fetal Exchange; D008598:Menstruation / Q000187:drug effects; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000139:chemically induced; D011272:Pregnancy, Multiple / Q000187:drug effects; D012189:Retrospective Studies; D014427:Twins; D014621:Vagina / Q000187:drug effects
D004054:Diethylstilbestrol