Levamisole reduces the thrombocytopenia associated with myxovirus vaccination.
Mature dogs were vaccinated with a myxovirus vaccine. At this time, half of the dogs were also given a subcutaneous injection of levamisole hydrochloride (2.2 mg/kg). Blood platelets were counted daily. The dogs that had received only the vaccine showed, after 48 hours, a 48% decrease in platelets. Levamisole reduced the thrombocytopenia associated with myxovirus vaccination. Levamisole could have a protective effect on platelets by preventing their aggregation induced by viral neuraminidase.
D000818:Animals; D004283:Dog Diseases / Q000209:etiology / Q000517:prevention & control*; D004285:Dogs; D007978:Levamisole / Q000627:therapeutic use*; D009975:Orthomyxoviridae / Q000276:immunology; D013921:Thrombocytopenia / Q000209:etiology / Q000517:prevention & control / Q000662:veterinary*; D014611:Vaccination / Q000009:adverse effects / Q000662:veterinary*; D014765:Viral Vaccines / Q000009:adverse effects*
D014765:Viral Vaccines; D007978:Levamisole