Effect of glucagon on the perfused rat hind-quarter vessles and on perfused coronary arteries of rabbit.
In rat hind-quarter perfusion experiments, glucagon (1 microgram) produced a significant vasodilation. On the other hand, in experiments with isolated perfused rabbit heart, glucagon (1 microgram) caused coronary vasoconstriction irrespective of whether noradrenaline was added to perfusion fluid or not. Glucagon had no effect on rate or force of contraction of heart.
D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D005934:Glucagon / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006614:Hindlimb / Q000098:blood supply; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D005934:Glucagon; D009638:Norepinephrine