Simplified method for determination of the tetracyclic antidepressant mianserin in human plasma using gas chromatography with nitrogen detection.
A simplified gas chromatographic method for determination of the antidepressant drug mianserin in human plasma is described. Application of a nitrogen-sensitive detector reduces the assay procedure to extraction, concentration and gas chromatographic determination. The method is suitable to determine mianserin in human plasma at the 1 ng/ml level on a routine basis. At the 20 ng/ml level the deviation of the mean from the true value and the relative standard deviation amount to 1.0% and 6.8%, respectively.
D002849:Chromatography, Gas / Q000379:methods*; D003984:Dibenzazepines / Q000097:blood*; D006801:Humans; D008803:Mianserin / Q000097:blood* / Q000627:therapeutic use
D003984:Dibenzazepines; D008803:Mianserin