title: Studies of hypolipidemic agents. 1. Synthesis and hypolipidemic activities of alkoxycinnamic acid derivatives.
abstract: More than 110 derivatives of alkoxycinnamic acids were synthesized and their hypolipidemic activities were evaluated in a screening system with rats. Cinnamic acids, alpha-methylcinnamic acids, and their various esters with a higher p-alkoxy substituent were found to possess hypolipidemic activities higher than or comparable to that of clofibrate. The proper length (C12--C16) and the para position of the alkoxy substituent seem to be essential for activity. Chloroethyl and methacryloxyethyl esters and monoglycerides of some of the active p-alkoxycinnamic acids were more active than the corresponding free acids.
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood; D002934:Cinnamates / Q000138:chemical synthesis* / Q000494:pharmacology; D002994:Clofibrate / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D008297:Male; D051381:Rats; D013329:Structure-Activity Relationship; D014280:Triglycerides / Q000097:blood
chemical_list: D002934:Cinnamates; D000960:Hypolipidemic Agents; D014280:Triglycerides; D002784:Cholesterol; D002994:Clofibrate