Selective depletion of spinal noradrenaline inhibits post-decapitation convulsions in rats.
Local administration of 6-hydroxydopamine in the subarachnoidal space of the spinal cord in rats resulted in a selective long-lasting depletion of spinal noradrenaline, but not of dopamine, and prevented the occurrence of post-decapitation convulsions.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology; D004298:Dopamine / Q000502:physiology*; D006892:Hydroxydopamines / Q000494:pharmacology*; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D011180:Postmortem Changes; D051381:Rats; D012640:Seizures / Q000503:physiopathology*; D013116:Spinal Cord / Q000187:drug effects / Q000502:physiology* / Q000503:physiopathology
D006892:Hydroxydopamines; D004298:Dopamine; D009638:Norepinephrine