Effect of fluoride on alpha-chymotrypsin.
Sodium fluoride has been demonstrated by spectrophotometric experiment to have an inhibitory effect on the hydrolyzing action of alpha-chymotrypsin. Sodium fluoride in moderate therapeutic dosage possibly can retard or completely inhibit the activity of bone-resorbing enzymes in the otospongiotic focus, thus retarding or arresting active expansion of a focus and resulting in stabilizing or arresting the progression of sensorineural hearing loss that is associated with otospongiosis.
D002918:Chymotrypsin / Q000037:antagonists & inhibitors*; D005459:Fluorides / Q000494:pharmacology*; D006801:Humans; D006868:Hydrolysis; D012969:Sodium Fluoride / Q000494:pharmacology*; D013053:Spectrophotometry
D012969:Sodium Fluoride; D002918:Chymotrypsin; D005459:Fluorides