title: Study of the teratogenic activity of ribosomal vaccine.
abstract: The investigation on the possible teratogenic activity of a vaccinal formula of ribosomes of Klebsiella pneumoniae, Streptococcus pneumoniae, Streptococcus pyogenes A12 and Haemophilus influenzae (D 53) was carried out in three animal species: rats, mice, rabbits. The trials were performed on two generatins of rats and mice, and on one single generation of rabbits. D 53 was given in s.c. injections (6 days a week) for 8 days before mating the females, and then until the females dropped (or were sacrificed when foetuses had to be removed by Caesarean operation). The possible teratogenic or embryotoxic effects of D 53 were evaluated using the following checks: fertility rates in the mated females; rates of placenta-foetal resorptions; abnormalites in foetuses and offspring (dissection and skeletal staining). In the above experimental conditions, D 53 had no embryotoxic and teratogenic activity in the 3 animal species used.
mesh_terms: D000818:Animals; D001428:Bacterial Vaccines / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D051379:Mice; D011247:Pregnancy; D011817:Rabbits; D051381:Rats; D012270:Ribosomes / Q000276:immunology*; D013045:Species Specificity; D013723:Teratogens
chemical_list: D001428:Bacterial Vaccines; D013723:Teratogens