Normal UV-induced DNA repair synthesis in peripheral leukocytes from patients with malignant melanoma of the skin.
Seventeen patients with malignant melanoma were compared to 24 control subjects regarding UV-induced DNA repair synthesis. Peripheral leukocytes were irradiated with different UV-doses and the DNA-repair synthesis was measured in presence of hydroxyurea. A dose response curve was established for each individual. No statistical differences were observed when melanoma patients were compared to the controls.
D000368:Aged; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology; D066298:In Vitro Techniques; D007962:Leukocytes / Q000503:physiopathology; D008545:Melanoma / Q000503:physiopathology*; D008875:Middle Aged; D012878:Skin Neoplasms / Q000503:physiopathology*; D014466:Ultraviolet Rays
D006918:Hydroxyurea