Inhibition of neutrophil migration by aggregated immunoglobulin attached to micropore membranes.
The effect of substrate-bound immunoglobulin on neutrophil migration was examined. Immunoglobulin aggregates bound to micropore membranes inhibited the neutrophil response to a chemotactic stimulus. This inhibition was reversed by the presence of aggregates in suspension suggesting competition between substrate-bound and free aggregates for neutrophil surface binding sites. The immobilization of neutrophils by substrate-bound aggregated immunoglobulin suggests a mechanism for the accumulation of neutrophils at sites of immune complex deposition and tissue-bound antibodies in vivo.
D002364:Caseins; D002464:Cell Migration Inhibition; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte; D006801:Humans; D007136:Immunoglobulins; D007958:Leukocyte Count; D008567:Membranes, Artificial; D009504:Neutrophils / Q000502:physiology*; D012709:Serum Albumin
D002364:Caseins; D007136:Immunoglobulins; D008567:Membranes, Artificial; D012709:Serum Albumin