title: A comparison of diluent and methacholine challenge with spirometry and the body plethysmograph.
abstract: Bronchial reactivity to inhaled diluent and methacholine was determined for asthmatics using automated spirometry. These data were compared with challenge data from a matched group of asthmatics previously studied plethysmographically. High correlations were obtained between all indices both groups, suggesting that spirometry is adequate for the clinical characterization of the methacholine response.
mesh_terms: D000328:Adult; D000402:Airway Obstruction / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008688:Methacholine Compounds / Q000494:pharmacology*; D008875:Middle Aged; D010366:Peak Expiratory Flow Rate; D010991:Plethysmography; D012996:Solutions; D013147:Spirometry
chemical_list: D008688:Methacholine Compounds; D012996:Solutions