Evaluation of methods used to estimate inhaled dose of carbon monoxide.
We have compared estimation of alveolar carbon monoxide measured either as end-expired or mixed-expired carbon monoxide tension with two spectrophotometric estimations of venous blood carboxyhaemoglobin (COHb). Estimation of mixed-expired carbon monoxide proved more convenient for patients than the end-expired method, and this estimation of carbon monoxide exposure discriminated between non-smokers and smokers as well as measurements of COHb. The technique is bloodless, economical, and simple to perform. It should prove a valuable method for validating reported smoking habits of people attending smoking advisory centres and for epidemiological surveys of smoking.
D002248:Carbon Monoxide / Q000032:analysis*; D002263:Carboxyhemoglobin / Q000032:analysis; D005069:Evaluation Studies as Topic; D006801:Humans; D001239:Inhalation; D008722:Methods; D010092:Oximetry; D010313:Partial Pressure; D011650:Pulmonary Alveoli; D012907:Smoking / Q000503:physiopathology; D013053:Spectrophotometry; D014680:Veins
D002248:Carbon Monoxide; D002263:Carboxyhemoglobin