[Blood coagulability and heart activity on intravenous thrombin administration].
It was shown in dog experiments that intravenous infusion of 30 and 70 U/kg of thrombin leads to the development of a short-term hypercoagulation phase which is replaced by long-term hypocoagulation and marked stimulation of fibrinolysis. An electrocardiogram provides evidence that after the infusion of 70 U/kg of thrombin acute ischemic disorders of coronary circulation develop in the dogs and remain for 3 days. The authors contend that the appearance of high doses of thrombin in the vascular channel is not a physiological reaction.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000187:drug effects*; D007275:Injections, Intravenous; D008297:Male; D013917:Thrombin / Q000008:administration & dosage*; D013997:Time Factors
D013917:Thrombin
Svertyvaemost' krovi i deiatel'nost' serdtsa pri vnutrivennom vvedenii trombina.