Transport of sugars and amino acids across guinea pig small intestine.
Using guinea pig small intestine for measurements of influx across the brush border membrane (Jmc), unidirectional transmural fluxes (Jms,Jsm), and steady-state epithelial uptake [A]c, the characteristics of the mutual inhibition were examined. The mutual inhibition of Jmc was in the range of 9--16%, and appeared to be sodium dependent, Jms and [A]c were inhibited by at least 40%, and Jsm was unaffected. All the results can be explained in terms of therheogenic version of the sodium gradient hypothesis. Whereas only the mutual inhibition of Jmc can also be explained in terms of allosteric interactions between the binding sites for sugars and amino acids.
D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D002462:Cell Membrane / Q000378:metabolism*; D005260:Female; D005690:Galactose / Q000378:metabolism* / Q000494:pharmacology; D006168:Guinea Pigs; D007421:Intestine, Small / Q000378:metabolism*; D007700:Kinetics; D008715:Methionine / Q000494:pharmacology; D008871:Microvilli / Q000187:drug effects / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*
D014364:Tryptophan; D008715:Methionine; D005690:Galactose