High resolution of a small pericentric inversion of chromosome 11.
A pericentric inversion 11 (p11q13.3) segragating in two generations is described. A high degree of resolution of the inversion was achieved by using prophase and prometaphase chromosomes from methotrexate-synchronised cells. The inversion occurred in a mother and three of her ten children. It had no detectable clinical consequences.
D000328:Adult; D002453:Cell Cycle / Q000187:drug effects; D002871:Chromosome Banding; D007446:Chromosome Inversion; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D008214:Lymphocytes / Q000648:ultrastructure; D010375:Pedigree