[Sulpiride and renal action of dopamine in hydro-saline depletion in humans].
The effect of sulpiride (racemic form) pretreatment on renal action of dopamine (DA) has been investigated in 8 hydro-saline depleted human subjects. Two studies were carried out in the presence and in the absence of sulpiride, respectively. DA was infused in a subpressor dose (0,1 microgram.kg-1 . min-1) during induced hypotonic polyuria. The experimental results suggest that tubular DA effects are enhanced whilst glomerular DA effects are reversed by the presence of sulpiride.
D000328:Adult; D001834:Body Water / Q000378:metabolism*; D004039:Diet, Sodium-Restricted; D004231:Diuresis / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007668:Kidney / Q000187:drug effects*; D009994:Osmolar Concentration; D012965:Sodium Chloride / Q000378:metabolism*; D013469:Sulpiride / Q000494:pharmacology*; D014868:Water Deprivation
D012965:Sodium Chloride; D013469:Sulpiride; D004298:Dopamine
Sulpiride e azione renale della dopamina nell'uomo in deplezione idro-salina.