Proliferation of cultured rabbit renal glomerular cells stimulated by platelet factor.
Platelet contents stimulated the proliferation of cultured rabbit renal glomerular (probably mesangial) cells. Growth stimulatory effect of platelet factor was heat-stable at 56 degrees C for 30 min. These results suggest that platelets play an important role in glomerular lesions in glomerulonephritis.
D000818:Animals; D001792:Blood Platelets / Q000032:analysis*; D002478:Cells, Cultured; D005260:Female; D007678:Kidney Glomerulus / Q000648:ultrastructure*; D011817:Rabbits; D014020:Tissue Extracts / Q000494:pharmacology
D014020:Tissue Extracts