Synthesis of steroidal 17 beta-carboxamide derivatives.
Several 17 beta-carboxamide derivatives of natural and fluorinated glucocorticoids have been synthesized. The 17 beta-carboxylic derivatives were obtained by periodic acid oxidation of their side chains. They were then activated by N-hydroxybenzotriazole (HOBT) and coupled to several primary amines. Using this method eleven 17 beta-carboxamide derivatives have been prepared in good yields.
D055598:Chemical Phenomena; D002621:Chemistry; D003345:Corticosterone / Q000031:analogs & derivatives; D003899:Desoximetasone / Q000031:analogs & derivatives; D003907:Dexamethasone / Q000031:analogs & derivatives; D005938:Glucocorticoids / Q000138:chemical synthesis*; D006854:Hydrocortisone / Q000031:analogs & derivatives; D008722:Methods
D005938:Glucocorticoids; D003899:Desoximetasone; D003907:Dexamethasone; D003345:Corticosterone; D006854:Hydrocortisone