A new method to determine urinary quinoline compounds in patients with bladder cancer.
We developed a new method to measure quinoline compounds including kynurenic acid, xanthurenic acid, and the 8-methyl ether of xanthurenic acid in the urine. The excretion of quinoline compounds in 33 patients with bladder cancer was investigated. Abnormal excretion of the 8-methyl ether of xanthurenic acid was confirmed in 13 patients. There were significant increases in the excretion of kynurenic acid and the 8-methyl ether of xanthurenic acid in males and of xanthurenic acid in females. After a L-tryptophan load, the excretion of all three derivatives was increased in males and kynurenic acid excretion was increased in females.
D000368:Aged; D005260:Female; D006801:Humans; D007736:Kynurenic Acid / Q000652:urine; D008297:Male; D008722:Methods; D008875:Middle Aged; D014364:Tryptophan / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000652:urine*; D014977:Xanthurenates / Q000652:urine*
D014977:Xanthurenates; C023664:xanthurenic acid 8-methyl ether; D014364:Tryptophan; D007736:Kynurenic Acid