Potent inhibition of oxidative phosphorylation by marine natural products.
Many lipid-soluble extracts from various marine organisms have a nonspecific depressant effect on smooth muscle contractions. Novel compounds isolated from such lipid-soluble extracts were tested for their effects on the respiration of rat liver mitochondria and produced potent stimulation or inhibition of oxygen uptake by the mitochondria.
D000818:Animals; D056890:Eukaryota / Q000032:analysis; D066298:In Vitro Techniques; D008386:Marine Biology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats
D010936:Plant Extracts