title: The effect of previous surgery, operating room environment, and preventive antibiotics on postoperative infection following total hip arthroplasty.
abstract: In 711 consecutive total hip arthroplasty operations, approximately 80% of patients were followed one to 7 years. Per priman operations outnumbered hips having had previous operations 511 to 200. The incidence of infection was higher in the hips having had previous operations (1.6 vs 3.5%). The overall incidence of deep infection was 16/711, or 23%. Analysis of the influences of operating room environment and preventative antibiotics revealed that there was a marked decrease in the attack rate of deep infection (7.6 vs 0.6%) when the Clean Room, personnel-isolator system, and preventative antibiotics were used. Reduced intraoperative wound bacterial contamination is accompanied by a reduced incidence of sepsis.
mesh_terms: D000391:Air Microbiology; D005500:Follow-Up Studies; D006621:Hip Joint / Q000601:surgery; D006622:Hip Prosthesis; D006801:Humans; D009355:Neomycin / Q000494:pharmacology*; D009873:Operating Rooms; D013530:Surgical Wound Infection / Q000209:etiology* / Q000517:prevention & control; D007507:Therapeutic Irrigation; D014691:Ventilation
chemical_list: D009355:Neomycin