title: Effects of a meal and gut hormones on plasma motilin and duodenal motility in dog.
abstract: Cyclic increases in the motilin level that coincided with phase III activity of interdigestive myoelectric activity of interdigestive myoelectric activity of the duodenum produced varied plasma motilin concentrations in a fasting dog. Ingestion of a meat meal not only abolished the cyclic increases in motilin concentrations, but also resulted in a significant decrease in the plasma motilin level that was accompanied by phase II-like myoelectric activity of the duodenum, a so-called digestive pattern. Although intravenous gastrin or cholecystokinin octapeptide (CCK-OP) or a combination of gastrin, CCK-OP, and secretin converted the interdigestive myoelectric activity to a digestive pattern, the cyclic increases in plasma motilin levels coulc not be changed by these hormones. This study indicates that a cyclic increase in motilin concentration occurs during the interdigestive period, but not during the digestive period. Instead, a significant decrease occurs. These changes in plasma motilin levels do not appear to be produced by three known gut hormones that are released after ingestion of a meal.
mesh_terms: D000818:Animals; D002417:Cattle; D002766:Cholecystokinin / Q000494:pharmacology*; D004285:Dogs; D004386:Duodenum / Q000502:physiology*; D004594:Electrophysiology; D005755:Gastrins / Q000494:pharmacology*; D005768:Gastrointestinal Hormones / Q000097:blood*; D005769:Gastrointestinal Motility / Q000187:drug effects; D008460:Meat; D009037:Motilin / Q000097:blood*; D009119:Muscle Contraction / Q000187:drug effects; D012633:Secretin / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D005755:Gastrins; D005768:Gastrointestinal Hormones; D012633:Secretin; D009037:Motilin; D002766:Cholecystokinin