title: 5,6-epoxyretinoic acid is a physiological metabolite of retinoic acid in the rat.
abstract: 5,6-Epoxyretinoic acid was detected in small intestine, kidney, liver, testes and serum of vitamin A-deficient rats 3 h after a single physiological dose of [3H]retinoic acid. The maximum concentration of 5,6-epoxide in intestinal mucosa was observed 3 h after intrajugular administration of retinoic acid. However, at 7 h post administration, no 5,6-epoxyretinoic acid was detected in mucosa, demonstrating the rapid intestinal metabolism or excretion of this metabolite. No 5,6-epoxy[3H]retinoic acid was detected in mucosa, liver or serum of retinoic acid-repleted rats 3 h after administration of 2 micrograms of [3H]retinoic acid.
mesh_terms: D000818:Animals; D002851:Chromatography, High Pressure Liquid; D004852:Epoxy Compounds / Q000378:metabolism; D007700:Kinetics; D008297:Male; D051381:Rats; D014018:Tissue Distribution; D014212:Tretinoin / Q000031:analogs & derivatives* / Q000378:metabolism; D014802:Vitamin A Deficiency / Q000378:metabolism
chemical_list: D004852:Epoxy Compounds; C018058:5,6-epoxyretinoic acid; D014212:Tretinoin