title: Origin of life: consideration of alternatives to proteins and nucleic acids.
abstract: Starting with relatively simple, non-hydrolyzable compounds in aqueous solution, entirely spontaneous condensations give rise to polymers that contain purines, pyrimidines, amino acids, coenzymes, lipid components and even phosphate. The presence of certain lipid micelles allows significant product formation at millimolar substrate concentrations. The first step involves formation of a Michael adduct from alpha-beta-unsaturated carbonyl compounds and various nucleophiles. Polymerization of these adducts occurs via sequential Knoevenagel condensations. All reactions take place readily at temperatures below 45 degrees. The polymers can act as macromolecular catalysts as evidenced by hydrolytic activity. The purines and pyrimidines in the polymers appear to be capable of both base pairing and stacking interactions with ribonucleic acids. Specific examples of potential alternatives to base pairing are presented. These results are discussed from the standpoint of the spontaneous development of reproducing molecules. Proteins and nucleic acids may be evolutionary developments which have displaced earlier biopolymers.
mesh_terms: D000596:Amino Acids; D005075:Biological Evolution; D001704:Biopolymers; D002384:Catalysis; D003067:Coenzymes; D008055:Lipids; D046911:Macromolecular Substances; D008823:Micelles; D009696:Nucleic Acids / Q000096:biosynthesis*; D009705:Nucleosides / Q000096:biosynthesis; D000069497:Origin of Life; D010710:Phosphates; D014176:Protein Biosynthesis; D011687:Purines; D011743:Pyrimidines; D013696:Temperature
chemical_list: D000596:Amino Acids; D001704:Biopolymers; D003067:Coenzymes; D008055:Lipids; D046911:Macromolecular Substances; D008823:Micelles; D009696:Nucleic Acids; D009705:Nucleosides; D010710:Phosphates; D011687:Purines; D011743:Pyrimidines