Pulmonary abnormalities in patients intravenously receiving the methanol extraction residue (MER) of Bacillus Calmette-Guerin.
Eight of 64 patients receiving intravenous administration of methanol extraction residue (MER) of Bacillus Calmette-Guerin (BCG), developed miliary-type pulmonary parenchymal changes. The clinical and radiological characteristics are described. An increased incidence was noted in patients with a history of previous BCG exposure or with positive PPD skin reactivity. Spontaneous resolution was observed upon discontinuation of MER. These changes most likely respresent a granulomatous inflammatory process, although no histological confirmation was obtained.
D000328:Adult; D001500:BCG Vaccine / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005260:Female; D006099:Granuloma / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000628:therapy*; D014391:Tuberculosis, Miliary / Q000175:diagnosis; D014397:Tuberculosis, Pulmonary / Q000175:diagnosis
D001500:BCG Vaccine