title: [High-performance liquid chromatographic determination of tetroxoprim and sulfadiazine in biological samples (author's transl)].
abstract: A specific and sensitive HPLC-analytical method was developed for the determination of 3-methoxy-6-sulfanilamidopyridazine (sulfadiazine) and 2,4-diamino-5-[3,5-dimethoxy-4-(2-methoxyethoxy)]-benzylpyrimidine (tetroxoprim), a new competitive inhibitor of bacterial dihydrofolate-reductases. The method has a sensitivity limit of 50 ng tetroxoprim/ml and 150 ng sulfadiazine/ml serum.
mesh_terms: D000890:Anti-Infective Agents / Q000032:analysis* / Q000097:blood / Q000652:urine; D002851:Chromatography, High Pressure Liquid; D008722:Methods; D011743:Pyrimidines / Q000032:analysis* / Q000097:blood / Q000652:urine; D013411:Sulfadiazine / Q000032:analysis* / Q000097:blood / Q000652:urine
chemical_list: D000890:Anti-Infective Agents; D011743:Pyrimidines; D013411:Sulfadiazine; C023507:tetroxoprim
vernacular_title: Bestimmung von Tetroxoprim und Sulfadiazin in Serum und Urin durch Hochdruckflüssigkeitschromatographie.