Detection thresholds to stimulation of ventrobasal complex in cats.
Cats were trained to indicate, by bar pressing for food rewards, their detection of stimulation of the ventrobasal (VB) complex delivered through implanted bipolar electrodes. By varying stimulus intensity it was possible to determine thresholds for detection. Scaling stimulus intensity relative to the appearance of a minimal evoked potential allowed comparisons between animals and also comparisons with results obtained by stimulation of peripheral nerve. Animals could detect VB stimulation, but only at stimulus intensities consistently stronger than those required for minimal appearance of an evoked response in ipsilateral primary somatosensory cortex. Results of VB activation differed from cutaneous nerve effects in that VB detection thresholds were markedly influenced by stimulus frequency. They were lowest at frequencies above 30 Hz and increased greatly at lower frequencies. Discomfort or pain did not seem to result even from relatively high stimulus intensities. The results compare well with observations obtained from stimulation of VB in humans. The appearance of an evoked cortical response is not necessarily correlated with behavior. Under appropriate conditions, behavior can be elicited predictably with minimal electrocortical activity; under other conditions detection may be absent even when large numbers of cortical neurons are activated. We suggest that regions of the cerebral cortex receiving thalamocortical projections from VB may not be essential in the detection process.
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D002415:Cats; D003216:Conditioning, Operant / Q000502:physiology; D003463:Cues; D004558:Electric Stimulation; D005071:Evoked Potentials; D008465:Mechanoreceptors / Q000502:physiology*; D012867:Skin / Q000294:innervation; D013003:Somatosensory Cortex / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*; D013788:Thalamus / Q000502:physiology*