Inhibition of the hypotensive effect of plasma protein solutions by C1 esterase inhibitor.
The hypotensive effect of stable plasma protein solution (SPPS) is a well-known phenomenon, causing serious problems in surgical patients and patients supported by cardiopulmonary bypass. Kinins are believed to be responsible. A study was made to prevent this hypotension by adding C1 esterase inhibitor to the SPPS and comparing this with 5% human albumin. The results shows a significant difference between the effects of SPPS and SPPS plus C1 esterase inhibitor infusion on bypass. Five percent human albumin did not cause hypotension. Possible sequelae are discussed.
D001794:Blood Pressure / Q000187:drug effects; D001798:Blood Proteins / Q000008:administration & dosage*; D002315:Cardiopulmonary Bypass; D003174:Complement C1 Inactivator Proteins / Q000627:therapeutic use*; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000517:prevention & control*; D008875:Middle Aged; D011292:Premedication
D001798:Blood Proteins; D003174:Complement C1 Inactivator Proteins