Increased sensitivity of cell strains from Cockayne's syndrome to sister-chromatid-exchange induction and cell killing by UV light.
Ultraviolet light-induced sister-chromatid exchanges (SCE) and cell killing were investigated in 4 fibroblast cell strains from patients with the sun-sensitive disease Cockayne's syndrome (CS). All 4 CS cell strains proved to be hypersensitive to UV for both of these end-points, but no close correlation between levels of SCE and lethality was observed. Cell strains from two individuals heterozygous for CS were indistinguishable from wild-type.
D002470:Cell Survival; D002478:Cells, Cultured; D003434:Crossing Over, Genetic; D004392:Dwarfism / Q000235:genetics*; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D010787:Photosensitivity Disorders / Q000235:genetics*; D011371:Progeria / Q000235:genetics*; D012854:Sister Chromatid Exchange; D012867:Skin / Q000528:radiation effects; D013577:Syndrome; D014466:Ultraviolet Rays