Is tubulin involved in the electrically-induced mechanical activity of the isolated rat sciatic nerve?
The electrically-induced mechanical activity of isolated segments of rat sciatic nerves remains unaffected following incubation with 10(-4) M colchicine, vinblastine or melatonin. Vinblastine depressed tubulin levels in incubated nerves. These results suggest that microtubules are not involved in nerve mechanical activity in vitro.
D000818:Animals; D003078:Colchicine / Q000494:pharmacology; D004558:Electric Stimulation; D008550:Melatonin / Q000494:pharmacology; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology*; D014404:Tubulin / Q000502:physiology*; D014747:Vinblastine / Q000494:pharmacology
D014404:Tubulin; D014747:Vinblastine; D008550:Melatonin; D003078:Colchicine