[Does a drug administered by oral route affect the transfer of maternal antibodies in piglets? (author's transl)].
The constituents of colostrum, which block the absorption of maternal antibodies shortly after the birth of piglets, are poorly defined. Therefore it cannot be stated off-hand whether the blocking of absorption may (also) be induced by oral administration of drugs shortly after parturition. To study this possibility, pregnant sows were immunized with bovine IgG, and a preparation of iron (used to prevent anaemia) was administered orally. The uptake of antibodies to bovine IgG in these piglets then was compared with that in a group of controls. In six out of sixteen litters studied, the uptake of antibodies was found to be significantly lower than that in the Fe-treated group. This adverse effect on the uptake of antibodies, resulting from the drug administered, would appear to warrant a closer study of this and other drugs to be administered shortly after parturition.
D000284:Administration, Oral; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D000906:Antibodies / Q000032:analysis; D002417:Cattle / Q000276:immunology; D003126:Colostrum / Q000276:immunology; D005260:Female; D007074:Immunoglobulin G / Q000378:metabolism*; D007408:Intestinal Absorption / Q000187:drug effects*; D007501:Iron / Q000008:administration & dosage* / Q000494:pharmacology; D011247:Pregnancy; D013552:Swine / Q000276:immunology*; D013997:Time Factors
D000906:Antibodies; D007074:Immunoglobulin G; D007501:Iron
Heeft een oraal toegediend preparaat invloed op de overdracht van maternale antilichamen bij de big?