[Comparative study of sisomicin and gentamycin action on the cells in a tissue culture].
The cytostatic effect of sisomicin and gentamicin, antibiotics from the group of aminoglycosides was studied comparatively with respect to three types of tripsinized cells of chick embryo (cells of the kidneys, liver and fibroblasts). It was found that epithelial cells and in particular kidney cells were most sensitive to the above antibiotics as compared to fibroblasts. It was also shown that gentamicin had a lower cytostatic effect on the embryonal cells of the kidneys, liver and fibroblasts as compared to sisomicin.
D000818:Animals; D002642:Chick Embryo; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000187:drug effects; D005839:Gentamicins / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D012853:Sisomicin / Q000494:pharmacology*
D005839:Gentamicins; D012853:Sisomicin
Sravnitel'noe izuchenie deĭstviia sizomitsina i gentamitsina na kletki v kul'ture tkani.