"Ecdysis" secondary to 5-fluorouracil.
The use of 5-fluorouracil in three patients with basal cell carcinoma was followed by a peculiar necrosis which, when curetted, shelled out completely like a snake skin. We have termed this "ecdysis." Histologic examination revealed tumor necrosis, leukocytes, and fibrin. There have been no recurrences to date.
D000368:Aged; D002280:Basal Cell Carcinoma / Q000188:drug therapy; D005260:Female; D005472:Fluorouracil / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D012867:Skin / Q000473:pathology; D012878:Skin Neoplasms / Q000188:drug therapy; D013262:Stevens-Johnson Syndrome / Q000209:etiology* / Q000473:pathology
D005472:Fluorouracil