Suppression of lymphocyte PHA-responsiveness after rubella vaccination with Cendehill and RA 27/3 strains.
Two rubella vaccine strains, Cendehill and RA 27/3, were compared with regard to their immunosuppressive effect in vivo. 26 female vaccinees were studied. Both vaccines caused a slight transient suppression of lymphocyte responsiveness to mitogens on day 11 after vaccination. A whole blood culture method was used for lymphocyte stimulation tests, and the method appeared suitable for clinical studies of cell-mediated immunity.
D002478:Cells, Cultured; D003470:Culture Media; D005260:Female; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D010835:Phytohemagglutinins; D012411:Rubella Vaccine / Q000276:immunology*; D014613:Vaccines, Attenuated
D003470:Culture Media; D010835:Phytohemagglutinins; D012411:Rubella Vaccine; D014613:Vaccines, Attenuated