Myocardial depressant fraction in the venom of Dendroaspis angusticeps.
Whole venom Dendroaspis angusticeps produced a negative chronotropic and ionotropic effect on the heart. Isolation of the fraction (T39) produced the same effect. Negative inotropic effect was blocked by atropine. The bradycardia may be due to a cholinergic effect and the negative ionotropic to a direct depressant effect on the myocardium.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D003864:Depression, Chemical; D004546:Elapid Venoms / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D011817:Rabbits; D013997:Time Factors
D004546:Elapid Venoms; D001285:Atropine