title: [Late sequelae of preventive radiation and chemotherapy of the cerebral cranium in children with acute leukemia (author's transl)].
abstract: In 15 children, combined treatment of the cerebral crane (irradiation + cytostatics) was done for acute leukemia, using Pinkel's or Riehm's method. In order to judge of late sequelae on the brain tissue, the cerebral crane was explored by means of computed tomography, generally more than a year later. Of 15 children 10 revealed slight or important parenchymal alterations being imputable to the former therapy. A possible augmentation of the sensitivity to radiation due to combined chemotherapy is discussed, and a revisal of therapeutic schedules, therefore, is recommended.
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007938:Leukemia / Q000532:radiotherapy*; D008297:Male; D008577:Meningeal Neoplasms / Q000517:prevention & control / Q000532:radiotherapy* / Q000556:secondary; D011867:Radioisotope Teletherapy / Q000009:adverse effects; D012640:Seizures / Q000000981:diagnostic imaging / Q000209:etiology; D014057:Tomography, X-Ray Computed
chemical_list: D003037:Cobalt Radioisotopes
vernacular_title: Spätfolgen präventiver Strahlen- und Chemotherapie des Hirnschädels bei Kindern mit akuter Leukämie.