Biochemical concept and synthesis of a radioiodinated phenylfatty acid for in vivo metabolic studies of the myocardium.
A biochemical concept is proposed for a radioiodinated fatty acid avoiding high iodine background in imaging studies of the myocardium. For this approach omega-(p-123I phenyl)-pentadecanoic acid is chosen and a method for synthesis and quality control described.
D000818:Animals; D005227:Fatty Acids / Q000138:chemical synthesis*; D006321:Heart / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D007462:Iodobenzenes / Q000138:chemical synthesis*; D007553:Isotope Labeling / Q000379:methods; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D011786:Quality Control; D011817:Rabbits; D011877:Radionuclide Imaging
D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C025391:omega-(4-iodophenyl)pentadecanoic acid