title: Familial testicular teratoma in 2 children: familial report and review of the literature.
abstract: Familial occurrence of a testicular tumor is rare. We report mature teratomas in 2 first cousins in a consanguineous family. The cases were unique because both tumors were pathologically similar and their onsets were close. Of 34 families with testicular neoplasms reviewed this is the first family composed of 2 affected children with mature teratomas. The analysis of the familial cases showed segregation of twins and a slightly higher incidence of bilateral tumors. The genetic roles are discussed in the etiology of testicular tumor.
mesh_terms: D006801:Humans; D007223:Infant; D008297:Male; D013724:Teratoma / Q000235:genetics* / Q000473:pathology; D013736:Testicular Neoplasms / Q000235:genetics* / Q000473:pathology