title: Disseminated porokeratosis Mibelli treated with RO 10-9359. A study of two cases with ultrastructural remarks.
abstract: 2 patients with widespread porokeratosis Mibelli (PM) were treated orally with RO 10-9359. The dose was 75 mg/day for 10 days, then 50 mg/day for 3 weeks. The drug produced a good improvement of condition with no serious side effect. Ultrastructural examination of a healed lesion showed the presence of a fine granular substance in the intercellular space of the spinous layer, most likely produced by keratinocytes; ultrastructural cellular alterations of PM were still evident and the lesion recurred after suspension of treatment.
mesh_terms: D000368:Aged; D005050:Etretinate / Q000627:therapeutic use*; D005533:Foot Dermatoses / Q000188:drug therapy / Q000473:pathology; D006229:Hand Dermatoses / Q000188:drug therapy / Q000473:pathology; D006801:Humans; D007642:Keratosis / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000648:ultrastructure; D013577:Syndrome; D014212:Tretinoin / Q000031:analogs & derivatives*
chemical_list: D014212:Tretinoin; D005050:Etretinate