[Effect of lysozyme suppression of factor XII activation on postadrenaline hypercoagulation].
Adrenaline administration (0.5 mg/kg) in rabbits shortened the blood clotting time for about 30 min, whereas under the lysozyme effect no shortening occurred. I. v. lysozyme administration (0.05 mg/kg) induced clear though transitory decrease of total and latent BAEE-esterase activity of the blood plasma. The data obtained emphasize the role of factor XII activation by adrenaline for physiological regulation of blood coagulability.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004789:Enzyme Activation / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology*; D004950:Esterases / Q000097:blood; D005174:Factor XII / Q000037:antagonists & inhibitors*; D005260:Female; D008297:Male; D009113:Muramidase / Q000494:pharmacology*; D011817:Rabbits; D014914:Whole Blood Coagulation Time
D005174:Factor XII; D004950:Esterases; D009113:Muramidase; D004837:Epinephrine
Vliianie podavleniia aktivatsii faktora XII lizotsimom na postadrenalinovuiu giperkoaguliatsiiu.