Single-dose kinetics predict steady-state concentrations on imipramine and desipramine.
Single-dose prediction of ultimate steady-state concentrations of tricyclic antidepressants at the outset of treatment can be a valuable therapeutic tool that has had only limited application. We demonstrate accurate steady-state predictions following both the tertiary amine, imipramine hydrochloride, and the secondary amine, desipramine hydrochloride, in a carefully monitored long-term treatment patient population. Results show that long-term treatment does not alter metabolism of either imipramine or desipramine. The relative merits of single-dose predictions using total and "abbreviated" areas under the curve and concentration at 24 hours are compared. These findings demonstrate that single-dose prediction can be used as a practical therapeutic, as well as, research tool.
D000293:Adolescent; D000328:Adult; D000342:Affective Symptoms / Q000097:blood / Q000188:drug therapy; D000368:Aged; D002849:Chromatography, Gas; D003891:Desipramine / Q000008:administration & dosage / Q000097:blood*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000008:administration & dosage / Q000097:blood*; D007700:Kinetics; D008297:Male; D013058:Mass Spectrometry; D008875:Middle Aged; D013997:Time Factors
D007099:Imipramine; D003891:Desipramine