Induction of cross-links between DNA and protein by PR toxin, a mycotoxin from Penicillium roqueforti.
PR toxin, a mycotoxin from Penicillium roqueforti, induces DNA--protein cross-links in chromatin of both cultured cells and isolated rat-liver nuclei. The presence of the aldehyde group in the PRT molecule is required for the induction of cross-linking; methylene bridges between nucleic acid and protein are presumably involved in the complex formation. The role of other functional groups of PR toxin is discussed.
D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D002478:Cells, Cultured; D002843:Chromatin / Q000187:drug effects*; D004247:DNA / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D009153:Mutagens; D009183:Mycotoxins / Q000494:pharmacology*; D010407:Penicillium; D051381:Rats
D002843:Chromatin; D009153:Mutagens; D009183:Mycotoxins; D004247:DNA