Action of histamine on phasic and tonic components of vascular smooth muscle contraction.
The isometric contractile response of rabbit aortic strips in response to histamine was studied. Biphasic dose-dependent contractions reflecting release of internal Ca2+ (phasic component) and simultaneous mobilization of external Ca2+ stores (tonic component) were produced.
D000818:Animals; D001011:Aorta / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006632:Histamine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits
D006632:Histamine