title: Involvement of ribonuclease in the interactions of macrophages and fibroblasts in experimental silicosis.
abstract: Decreased ribonuclease activity in the supernatant from silica-treated macrophages is associated with the enhanced protein synthesis in granulation-tissue slices incubated in this supernatant, and with the decreased degradation of polysomes in granuloma slices and of polysomes isolated from the granulation tissue. The phagocytized silica particles adsorb ribonuclease and perhaps other proteins and thus remove them from the macrophage supernatant.
mesh_terms: D000818:Animals; D005260:Female; D005347:Fibroblasts / Q000378:metabolism; D066298:In Vitro Techniques; D008264:Macrophages / Q000201:enzymology*; D011132:Polyribosomes / Q000378:metabolism; D014176:Protein Biosynthesis; D051381:Rats; D012260:Ribonucleases / Q000378:metabolism*; D012825:Silicon / Q000494:pharmacology*; D012829:Silicosis / Q000201:enzymology
chemical_list: D012260:Ribonucleases; D012825:Silicon