Secretory IgA content in human normal and tumoral bronchial mucosa in vitro.
Secretory IgA-S content was evaluated in vitro in human normal and tumoral bronchial mucosa from 39 cases. In 75% of the cases, IgA-S production by tumoral tissue was higher than the levels found in control populations. On the other hand, IgA-S synthesis by normal bronchial tissue of patients with lung tumors, particularly with squamous cell carcinoma, was increased in comparison with patients free of neoplastic bronchopulmonary disease, in 30% of the cases. Comparing tumorous tissue with normal mucosa from the contralateral bronchus of the same patient, marked differences in IgA-S patterns were observed. Regarding the results obtained, we could consider the measuring of IgA-S in bronchial mucosa as a valuable diagnostic aid in patients with suspect pulmonary masses.
D001980:Bronchi / Q000276:immunology*; D002283:Carcinoma, Bronchogenic / Q000276:immunology*; D006801:Humans; D007070:Immunoglobulin A / Q000032:analysis*; D007071:Immunoglobulin A, Secretory / Q000032:analysis* / Q000096:biosynthesis; D066298:In Vitro Techniques; D008175:Lung Neoplasms / Q000276:immunology*; D009092:Mucous Membrane / Q000276:immunology
D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory