Spinal muscular atrophy and hypertrophy of the calves.
In 100 patients (59 males and 41 females) suffering from proximal spinal muscular atrophy, 23 presented with hypertrophy of the calves. These were all males. They all showed an elevation of serum CK-activity. The combination of spinal muscular atrophy, hypertrophy of the calves and elevated serum CK activity was not found in females.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D006984:Hypertrophy; D007223:Infant; D007866:Leg; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000473:pathology*; D009133:Muscular Atrophy / Q000201:enzymology / Q000473:pathology*; D012737:Sex Factors
D003402:Creatine Kinase