Determining aminoglycoside dosage and blood levels using a programmable calculator.
A programmable calculator procedure for the determination of dosage regimens and steady-state peak and trough levels of aminoglycoside antibiotics is described. The calculator is programmed based on a one-compartment open model and first-order elimination of aminoglycosides. A detailed description of the programs and user instructions are presented. The programs allow calculation of intermittent i.v. infusion dosage regimens and steady-state levels, and adjustment of dosage and dosing interval when measured plasma levels differ significantly from predicted levels. The calculator programs provide a rapid means of predicting and modifying dosage regimens and steady-state plasma levels for aminoglycoside antibiotics.
D000617:Aminoglycosides / Q000008:administration & dosage / Q000097:blood; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000097:blood; D003201:Computers; D004334:Drug Administration Schedule; D006801:Humans; D007263:Infusions, Parenteral; D007700:Kinetics; D008954:Models, Biological
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents