Phenytoin kinetics in children.
Infants and children taking phenytoin by mouth every 12 hr had relatively little fluctuations in serum levels measured every 4 hr after a dose. As the average level rose, the relative fluctuation in level was reduced, consistent with nonlinear elimination kinetics. Levels 8 hr after the dose had the least variability and were 104% of the average level over the 12-hr period.
D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006207:Half-Life; D006801:Humans; D007223:Infant; D007700:Kinetics; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*
D010672:Phenytoin