[Lipid peroxidation and state of certain components of anti-oxidant system in the liver of animals with burns].
The burn disease increases the intensity of lipid peroxidation in the guinea pigs plasma and liver. Under these conditions in the liver the content of ascorbic acid lowers and a high level of reduced glutathione is maintained due to an increase in the glucose-6-phosphate dehydrogenase activity. Disproteinemia is observed in plasma. Administration of alpha-tocopherol and sodium selenite to animals with the burn disease inhibits lipids peroxidation, favours the retaining of the ascorbic acid content in the liver tissue, prevents a compensatory increase in the glucose-6-phosphate dehydrogenase activity and a rise in the level of reduced glutathione. It also weakens disproteinemia in plasma.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D001798:Blood Proteins / Q000378:metabolism; D002056:Burns / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D006168:Guinea Pigs; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D010084:Oxidation-Reduction
D001798:Blood Proteins; D008054:Lipid Peroxides; D005954:Glucosephosphate Dehydrogenase; D005978:Glutathione; D001205:Ascorbic Acid
Perekisnoe okislenie lipidov i sostoianie otdel'nykh komponentov antioksidantnoĭ sistemy v tkani pecheni pri ozhogovoĭ bolezni.