Unusually high creatine kinase BB isoenzyme and study of lactate dehydrogenase pattern in metastatic adenocarcinoma of the prostate.
We report a case of metastatic adenocarcinoma of the prostate with widespread bony and hepatic involvement having extremely high BB isoenzyme of creatine kinase in serum (2405 U/liter). The serum LD5/LD1 ratio is greater than one, with total LD activity more than twenty-five fold the normal value. The homogenate of prostate gland of the patient shows an extra band with electrophoretic mobility between MM and MB isoenzymes of creatine kinase and highly elevated LD5 fraction compared to LD1 (33% vs. 9%), a remarkable LD isoenzyme pattern of malignant prostate tissue.
D000230:Adenocarcinoma / Q000201:enzymology*; D000368:Aged; D003402:Creatine Kinase / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D008297:Male; D009362:Neoplasm Metastasis; D011467:Prostate / Q000201:enzymology*; D011471:Prostatic Neoplasms / Q000201:enzymology*
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase