Differential turnover of rat liver isoferritins.
Rat liver ferritins consist of families of isoferritins fashioned from different proportions of two subunit types, H and L. Iron administration alters both the absolute and the relative amounts of these isoferritins through an increase in L-rich forms. This phenotype change represents preferential synthesis of L-rich isoferritins together with a faster degradation of H-rich isoferritins. The turnover rates of isoferritins in the same liver are markedly different and vary progressively with subunit composition. The H and L subunits in individual isoferritins appear to turn over at similar rates, suggesting that the various isoferritins are degraded as intact shells rather than through exchange and degradation of subunits.
D000818:Animals; D002250:Carbon Radioisotopes; D005293:Ferritins / Q000378:metabolism*; D007501:Iron / Q000494:pharmacology; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D046911:Macromolecular Substances; D008297:Male; D051381:Rats; D014316:Tritium
D002250:Carbon Radioisotopes; D046911:Macromolecular Substances; D014316:Tritium; D005293:Ferritins; D007501:Iron