The effect of hexachlorophene on the optic nerve and visual faculty in Beagle dogs after prolonged dermal application.
In a systemic tolerance study in Beagle dogs the effect of an ointment, containing 1, 3 or 10% hexachlorophene (HCP), applied dermally, on the optic system over a period of 12 weeks was investigated. Besides an irreversible loss of visual faculty during treatment with 3 and 10% HCP, a permanent mydriasis, peripapillary exudations and other alterations of the ocular fundus were observed at the same dose levels, suggesting that HCP has a strong affinity to the optic nervous system in dogs without clear-cut correlations to HCP plasma levels.
D000287:Administration, Topical; D000818:Animals; D004285:Dogs; D005123:Eye / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005654:Fundus Oculi; D006582:Hexachlorophene / Q000097:blood / Q000633:toxicity*; D008297:Male; D009900:Optic Nerve / Q000187:drug effects*; D012869:Skin Absorption; D013045:Species Specificity; D013997:Time Factors
D006582:Hexachlorophene