title: Acute FeCl3-induced epileptogenic foci in cats: electrophysiological analyses.
abstract: Fifteen cats were rendered acutely epileptic via transpial iontophoresis of ferric ions. Extracellular electrical activity of individual cortical neurons was temporally correlated with ECoG epileptic spikes. Each unit's activity was characterized as excited, inhibited, or unaffected. The spatial coordinates of each neuron were logged, thereby generating a 3-dimensional activity map. Discharge patterns were further classified as bursting or non-bursting. A significantly increased population of inhibited cells was detected at radial distances greater than 3 mm from the iontophoretic site. This increase was at the expense of "unaffected-bursting" cells. Pathological discharge patterns, including units which fired in long-first-interval bursts, were common in the focus. A system was designed to electronically calculate single-unit firing probability before, during and after surface epileptiform spikes. An 8-12 Hz oscillation in firing probability level, time-locked to the epileptic spike, was observed in most excited-bursting units. Many of these findings in the ferric-induced epileptic focus accurately model the electrophysiological characteristics previously reported for human epileptic foci examined at neurosurgery.
mesh_terms: D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects*; D004569:Electroencephalography; D005071:Evoked Potentials / Q000187:drug effects; D005290:Ferric Compounds / Q000494:pharmacology*; D007501:Iron / Q000494:pharmacology*; D009433:Neural Inhibition / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced*
chemical_list: D005290:Ferric Compounds; D007501:Iron