Sinonasal cancer and occupation: a case-control study.
In reviews of malignancy and occupation, cancer of the nose and paranasal sinuses (sinonasal cancer (SNC) is frequently mentioned. In a case-control study of SNC among subjects who died in Connecticut in the period 1935--1975, occupations from death certificates and city directories were compared to job titles taken from previous literature. The results do not support an association of the cancer with nickel (odds ratio = 0.7, 95% confidence limits (CL): 0.4, 1.5) but do support an association with cutting oils (odds ratio = 2.8, 95% CL: 1.4, 5.7) and wood dust (odds ratio = 4.0, 95% CL: 1.5, 10.8). Actual exposure to these agents was not documented, but the results were consistent with other features of the study and with previous literature. In a search for other occupational correlates, SNC was also found to be positively associated with cutters and with construction workers.
D000328:Adult; D000368:Aged; D003237:Connecticut; D004391:Dust; D006801:Humans; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects; D009669:Nose Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D009784:Occupational Diseases / Q000139:chemically induced*; D009790:Occupations; D009821:Oils / Q000009:adverse effects; D010255:Paranasal Sinus Neoplasms / Q000139:chemically induced* / Q000453:epidemiology; D014934:Wood
D004391:Dust; D009821:Oils; D009532:Nickel