Inhibition of in vitro cytochrome P-450-catalyzed reactions by substituted pyridines.
A series of substituted pyridines was investigated as inhibitors of cytochrome P-450-catalyzed reactions. The relative potencies for the in vitro inhibition of aminopyrine demethylation and aniline hydroxylation are reported for a series of 2-, 3-, and 4-substituted pyridines.
D000632:Aminopyrine / Q000378:metabolism; D000814:Aniline Compounds / Q000378:metabolism; D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D066298:In Vitro Techniques; D008297:Male; D011725:Pyridines / Q000494:pharmacology*; D051381:Rats
D000814:Aniline Compounds; D065607:Cytochrome P-450 Enzyme Inhibitors; D011725:Pyridines; D000632:Aminopyrine