Double-blind double-dummy crossover comparison of the effect of a single dose of cimetidine and trithiozine on gastric secretion.
Twelve patients with duodenal ulcer were admitted to a double-blind double-dummy single dose study in which the H2-receptor antagonist effect of Cimetidine and the activity of Trithiozine, endowed with an unknown mechanism, on gastric acid secretion were compared. For the balanced incomplete block design each patient received two out of four treatments. The single doses tested were 200 and 400 mg of both drugs. Cimetidine reduced all the parameters investigated, while Trithiozine increased basal acid output and acid concentration and did not affect maximal and peak acid output, basal and maximal volume and maximal acid concentration. The multiple range comparison between mean adjusted differences of the four doses were significantly in favour of Cimetidine, except for PAO, basal volume and basal acid concentration, despite the remarkable percent difference between Cimetidine and Trithiozine. In this study, Cimetidine confirmed its inhibitory properties, and Trithiozine did not appear to be an antisecretory agent.
D000328:Adult; D002927:Cimetidine / Q000494:pharmacology*; D004311:Double-Blind Method; D004381:Duodenal Ulcer / Q000378:metabolism; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D005765:Gastrointestinal Agents / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009025:Morpholines / Q000494:pharmacology*; D013276:Stomach Ulcer / Q000378:metabolism; D013997:Time Factors
D005765:Gastrointestinal Agents; D006146:Guanidines; D009025:Morpholines; D002927:Cimetidine; C012595:trithiozine