title: Cytotoxic effects of erythromycin estolate and chlorpromazine on hepatocytes isolated from rats of varying ages: a brief note.
abstract: Hepatocytes isolated from young (1 month) rats were as sensitive to the cytotoxic effects of erythromycin estolate and chlorpromazine as were liver cells obtained from older (3, 10 and 24 months) rats. The hepatocytes from the 24-month-old rats released aspartate transaminase more slowly than did parenchymal cells isolated from the younger rats.
mesh_terms: D000375:Aging; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D002457:Cell Extracts; D002746:Chlorpromazine / Q000633:toxicity*; D004917:Erythromycin / Q000031:analogs & derivatives*; D004918:Erythromycin Estolate / Q000633:toxicity*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats
chemical_list: D002457:Cell Extracts; D004917:Erythromycin; D001219:Aspartate Aminotransferases; D002746:Chlorpromazine; D004918:Erythromycin Estolate