Rate of oxygen consumption of hamster melanoma cells as a factor influencing their radioresistance.
It has been reported in recent years that the level of radiosensitivity of neoplastic cells in vivo and of sphaeroids in vitro can be modified by controlling their rate of oxygen consumption. Thus, an attempt was made to compare this rate in the case of the melanotic and amelanotic lines of Bomirski hamster melanoma in vitro, as it is known that these two lines distinctly differ in their reactivity to ionizing radiations. The measurements carried out by the use of a new ESR method revealed that pigmented and pigmentless cells consume oxygen at significantly different rates. This means that oxygen utilization may contribute to the overall level of radioresistance of melanoma cells.
D000818:Animals; D006224:Cricetinae; D066298:In Vitro Techniques; D008545:Melanoma / Q000532:radiotherapy / Q000648:ultrastructure*; D008647:Mesocricetus; D008928:Mitochondria / Q000378:metabolism* / Q000528:radiation effects; D009374:Neoplasms, Experimental / Q000532:radiotherapy / Q000648:ultrastructure; D010101:Oxygen Consumption; D011836:Radiation Tolerance; D012878:Skin Neoplasms / Q000532:radiotherapy / Q000648:ultrastructure*