title: Combination urea and salicyclic acid ointment nail avulsion in nondystrophic nails: a follow-up observation.
abstract: Following the initial report by Farber and South on nonsurgical nail avulsion with urea ointment and their emphasis that the therapy was not helpful in treating nondystrophic nails, we utilized a similar therapy to treat a sixty-seven year old patient who had severe arteriosclerotic cardiovascular disease and relatively nondystrophic but symptomatic large toenail disease. Because their formulation was ineffective on nondystrophic nails, a formulation with an additive, 20 percent urea and 10 percent salicylic acid preparation was used. After a period of two weeks of occlusive paplication, painless nonsurgical avulsion was achieved. Moderate maceration of surrounding skin was temporary and relatively asymptomatic.
mesh_terms: D000368:Aged; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009260:Nail Diseases / Q000628:therapy*; D009262:Nails / Q000187:drug effects*; D009824:Ointments; D012459:Salicylates / Q000494:pharmacology / Q000627:therapeutic use*; D014508:Urea / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D004338:Drug Combinations; D009824:Ointments; D012459:Salicylates; D014508:Urea