Beta-chain contact sites in the haemoglobin S polymer.
The amino acid residues involved in the areas of contact that stabilise the haemoglobin S polymer fibre seem to be the same ones that stabilise the basic unit of the deoxyhaemoglobin S crystal: the Wishner-Love double strand. The haemoglobin S fibre is probably formed by a unique packing of these double strands.
D001665:Binding Sites; D003460:Crystallization; D006451:Hemoglobin, Sickle / Q000235:genetics; D006455:Hemoglobins, Abnormal / Q000235:genetics; D006801:Humans; D009154:Mutation; D011485:Protein Binding
D006451:Hemoglobin, Sickle; D006455:Hemoglobins, Abnormal