Effect of prostaglandins A-1, E-2 and F-2 alpha on spermatogenesis in rats.
Rats were treated with twice daily injections of 100 microgram PG/rat for 15 days. PGA-1 had no effect. PGE-2 caused a significant increase in testicular weight, RNA content, hyaluronidase activity and number of spermatids. PGF-2 alpha produced a significant decrease in sorbitol dehydrogenase activity and DNA content. It is suggested that PGE-2 may be involved in later stages of spermatogenesis, i.e. conversion of spermatocytes to spermatids.
D000818:Animals; D008297:Male; D011454:Prostaglandins A / Q000494:pharmacology*; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects / Q000378:metabolism
D011454:Prostaglandins A; D011458:Prostaglandins E; D011460:Prostaglandins F