Central and peripheral actions of amphetamine on memory storage.
These experiments investigated the effects of central (intracerebroventricular) and peripheral (i.p.) posttraining administration of D-amphetamine on rat's retention of a one-trial inhibitory avoidance response. While retention was enhanced by i.p. administration (1.0 mg/kg) the central administration (dose range 50-500 microgram) did not affect retention. In rats given peripheral 6-OHDA 24 h prior to training a lower dose (i.p.) of amphetamine (0.25 mg/kg) was most effective in enhancing retention. These findings suggest that the mrmory enhancing effects of D-amphetamine are mediated at least in part through peripheral systems.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003913:Dextroamphetamine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006892:Hydroxydopamines / Q000494:pharmacology; D007276:Injections, Intraventricular; D008297:Male; D008568:Memory / Q000187:drug effects*; D009043:Motor Activity / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects*; D013564:Sympathetic Nervous System / Q000187:drug effects
D006892:Hydroxydopamines; D003913:Dextroamphetamine; D009638:Norepinephrine