Total replacement of blood by an emulsion of fluorocarbon in the rat--water extravasation as a cause of failure.
After exchange transfusion by an emulsion of fluorocarbons (Fluosol 43) in rats, an increase in fluorocarbons and 131I-labelled albumin was observed. These changes suggest a transfer of water from vascular to interstitial space possibly owing to the inability of the emulsion to reproduce the oncotic pressure of normal blood.
D000818:Animals; D001790:Blood Physiological Phenomena; D001834:Body Water / Q000378:metabolism; D005078:Exchange Transfusion, Whole Blood; D005466:Fluorocarbons / Q000494:pharmacology*; D007700:Kinetics; D051381:Rats; D012709:Serum Albumin / Q000378:metabolism
D005466:Fluorocarbons; D012709:Serum Albumin