Partial denervation in inactive muscle effects innervated and denervated fibres equally.
Possible causal factors of denervation-induced changes in muscle include inactivity, products of nerve degeneration and lack of a nerve-borne trophic agent. We now show that if the innervated fibres in a partially denervated rat muscle are rendered inactive, they undergo a reaction as intense as that of the denervated fibres. This provides further support for the view that the effects of denervation on the extrajunctional muscle membrane result from a combination of muscle inactivity and of nerve breakdown products acting diffusely throughout the muscle.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D009045:Motor Endplate / Q000187:drug effects; D009121:Muscle Denervation; D009132:Muscles / Q000187:drug effects / Q000502:physiology*; D009410:Nerve Degeneration; D051381:Rats; D013779:Tetrodotoxin / Q000494:pharmacology
D013779:Tetrodotoxin