Excretion of polyamines by children with Beckwith's syndrome.
The urinary excretion of the polyamines--putrescine, spermidine, and spermine--was measured in 7 children with Beckwith's syndrome. Putrescine excretion was raised and spermidine excretion reduced. The raised putrescine and the low spermidine ratios were highly significant. These results are consistent with a disturbance in a metabolic pathway under growth hormone-like regulation.
D002648:Child; D002675:Child, Preschool; D005877:Gigantism / Q000652:urine*; D006554:Hernia, Umbilical / Q000652:urine*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008260:Macroglossia / Q000652:urine*; D011073:Polyamines / Q000652:urine*; D013577:Syndrome
D011073:Polyamines