Human neuropharmacological findings with oxapadol (MD 720111), a new non-narcotic analgesic.
The effects of oxapadol, a new non-narcotic analgesic, were tested in man using the electrically-induced nociceptive flexion reflex in the flexor muscles of the lower limb as an index of pain. The drug caused a significant increase in the threshold of the reflex whereas no change was noted with placebo.
D000328:Adult; D000700:Analgesics / Q000494:pharmacology*; D001381:Azepines / Q000494:pharmacology*; D001562:Benzimidazoles / Q000494:pharmacology*; D004341:Drug Evaluation; D006801:Humans; D009619:Nociceptors / Q000187:drug effects; D010077:Oxazepines / Q000494:pharmacology*; D010146:Pain / Q000188:drug therapy; D012018:Reflex / Q000187:drug effects
D000700:Analgesics; D001381:Azepines; D001562:Benzimidazoles; D010077:Oxazepines; C023515:oxapadol