Placental hormones, nutrition, and fetal development.
Fetal growth retardation due to maternal malnutrition is widespread especially in the Third World. Little is known about the mechanisms that regulate the growth of the fetus and placenta during protein malnutrition. It is known that the placental size and levels of circulating placental hormones such as human chorionic gonadotrophins (hCG), human placental lactogen (hPL), and estrogens are affected by the nutritional status of the mother. There is suggestive evidence that during malnutrition, hPL may increase lipolysis and exert a glucose sparing effect in the mother, thereby promoting glucose availability to the fetus. We have studied the influence of dietary protein deficiency on the binding of dexamethasone to the specific cytosol receptors in adult and fetal tissues. A low protein diet in adult male rats is associated with a decrease in dexamethasone binding to liver cytosol receptors. On the other hand, protein deprivation in pregnant female rats leads to an increase in dexamethasone binding to liver cytosol receptors of both the mother and fetus. However, the influences of maternal protein deprivation on dexamethasone receptors in the fetal liver and lungs are not similar. At 21 days gestation the binding of dexamethasone to fetal lung receptors of protein-deficient mothers is lower than that in the controls. These differences at a critical time in the fetal lung development indicate that a fall in receptors for dexamethasone may lead to impaired phospholipid synthesis in fetuses of protein-deficient mothers and point to the importance of nutritional factors in the biochemistry of fetal development.
D000818:Animals; D006063:Chorionic Gonadotropin / Q000502:physiology; D003907:Dexamethasone / Q000378:metabolism; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008431:Maternal-Fetal Exchange; D009748:Nutrition Disorders / Q000503:physiopathology*; D010922:Placenta Diseases / Q000209:etiology; D010926:Placental Hormones / Q000502:physiology*; D010928:Placental Lactogen / Q000502:physiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011488:Protein Deficiency / Q000503:physiopathology; D051381:Rats
D006063:Chorionic Gonadotropin; D010926:Placental Hormones; D003907:Dexamethasone; D010928:Placental Lactogen; D005947:Glucose