Chlorpromazine and lidocaine inhibit antibody-dependent cell-mediated cytotoxicity but not erythrocyte antibody rosette formation.
Pretreatment of human peripheral blood mononuclear cells with chlorpromazine and lidocaine reduces their ability to induce lysis of antibody-coated target cells. This effect of local anesthetics was not due to a reduction of binding of antibody-coated red cells to the mononuclear cells, but it was rather probably due to the inhibition of mobility of the Fc receptor on the cell membrane.
D000920:Antibody-Dependent Cell Cytotoxicity / Q000187:drug effects*; D002462:Cell Membrane / Q000276:immunology; D002746:Chlorpromazine / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D007962:Leukocytes / Q000276:immunology; D008012:Lidocaine / Q000494:pharmacology*; D011961:Receptors, Fc / Q000187:drug effects; D012397:Rosette Formation
D011961:Receptors, Fc; D008012:Lidocaine; D002746:Chlorpromazine