Abnormal sensitivity of diploid skin fibroblasts from a family with gardner's syndrome to the lethal effects of X-irradiation, ultraviolet light and mitomycin-C.
Skin fibroblasts isolated from two members of the same family with the cancer-prone disease Gardner' Syndrome (intestinal polyposis, colon cancer, bone and soft tissue tumors) showed enhanced sensitivity to the lethal effects of X-irradiation, ultraviolet light and mitomycin-C. These cells showed no liquid-holding type recovery following UV-irradiation of confluent cultures, but were normal in their capacity for UV-induced unscheduled DNA synthesis. UV survival was not influenced by post-irradaiation incubation with caffeine.
D000328:Adult; D002470:Cell Survival; D002478:Cells, Cultured; D003110:Colonic Neoplasms / Q000235:genetics*; D004261:DNA Replication; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D006801:Humans; D007417:Intestinal Polyps / Q000235:genetics*; D008875:Middle Aged; D008937:Mitomycins / Q000494:pharmacology*; D009369:Neoplasms / Q000235:genetics; D012867:Skin / Q000187:drug effects* / Q000528:radiation effects*; D013577:Syndrome; D014466:Ultraviolet Rays; D014965:X-Rays
D008937:Mitomycins