Clinical radioimmunodetection of cancer with radioactive antibodies to human chorionic gonadotropin.
Injection of iodine-131-labeled goat immunoglobulin G antibody to human chorionic gonadotropin (hCG) into patients with hCG-secreting trophoblastic and germinal tumors permitted tumor detection and location by external gamma-ray scintigraphy. Excision of one of the metastatic tumors located by this method indicated a tumor/nontumor ration of 39.29. The method appears to offer a new clinical tool for precisely locating hCG-producing tumors in the body, even when tumor identification by other clinical methods has failed.
D000906:Antibodies / Q000008:administration & dosage*; D002822:Choriocarcinoma / Q000000981:diagnostic imaging*; D006063:Chorionic Gonadotropin / Q000276:immunology*; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000000981:diagnostic imaging*; D007074:Immunoglobulin G / Q000008:administration & dosage; D011247:Pregnancy; D011863:Radioimmunoassay / Q000379:methods; D011877:Radionuclide Imaging / Q000379:methods; D013724:Teratoma / Q000000981:diagnostic imaging*; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging*
D000906:Antibodies; D006063:Chorionic Gonadotropin; D007074:Immunoglobulin G