title: Stimulation of peripheral blood lymphocytes of children by influenza vaccine.
abstract: Cell cultures were performed with the blood of children, adults and umbilical cords in an examination of the effects of influenza vaccines. Commercially prepared whole virus vaccines containing swine +/- human virus antigens had a stimulatory effect upon peripheral blood lymphocytes of children but not adults. The stimulatory effect was shown to be retained by a fraction of whole influenza virus vaccine, but not subunit virus vaccine, is known to stimulation of blood lymphocytes by commercial subunit vaccines of either monovalent swine influenza or a trivalent composition. Immunization with whole influenza virus vaccine, but not subunit virus vaccine, is known to produce a high incidence of generalized reactions in children but not adults. The lymphocyte stimulation observed here may represent an in vitro counterpart of the in vivo reactions.
mesh_terms: D000375:Aging; D000914:Antibodies, Viral / Q000096:biosynthesis; D002455:Cell Division; D002478:Cells, Cultured; D002648:Child; D002675:Child, Preschool; D005312:Fetal Blood / Q000166:cytology; D006386:Hemagglutination Tests; D006801:Humans; D007223:Infant; D007252:Influenza Vaccines / Q000276:immunology / Q000494:pharmacology*; D008214:Lymphocytes / Q000166:cytology*; D010835:Phytohemagglutinins / Q000494:pharmacology
chemical_list: D000914:Antibodies, Viral; D007252:Influenza Vaccines; D010835:Phytohemagglutinins