Basis of phencyclidine's ability to decrease the synaptosomal accumulation of 3H-catecholamines.
Mixed cortical and hypothalamic synaptosomes and striatal synaptosomes were allowed to accumulate 3H-norepinephrine and 3H-dopamine, respectively, for 5 min in the absence and presence of phencyclidine. The results indicate that phencyclidine probably decreased the accumulation of 3H-norepinephrine into mixed cortical and hypothalamic synaptosomes by only blocking the uptake of the 3H-amine. On the other hand, part of the decrease in accumulation of 3H-dopamine elicited by 10 muM of PCP was probably caused by PCP releasing previously accumulated 3H-dopamine.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002395:Catecholamines / Q000378:metabolism*; D003864:Depression, Chemical; D004298:Dopamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism
D002395:Catecholamines; D010622:Phencyclidine; D004298:Dopamine; D009638:Norepinephrine