The pharmacokinetics of methimazole after oral administration of carbimazole and methimazole, in hyperthyroid patients.
1 Methimazole plasma concentrations were measured in two groups of hyperthyroid subjects after the oral administration of either carbimazole or methimazole. 2 With the HPLC method it was also possible to measure the concentration of a methimazole metabolite, 3-methyl-2-thiohydantoin in one patient. 3 Large interindividual differences were observed, especially within the carbimazole group. 4 Incomplete absorption of carbimazole could explain particular high apparent volumes of distribution and apparent clearances.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002231:Carbimazole / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D008713:Methimazole / Q000008:administration & dosage / Q000378:metabolism* / Q000627:therapeutic use; D008875:Middle Aged
D008713:Methimazole; D002231:Carbimazole