Fluorescence assay of nitrofurantoin with o-aminothiophenol in plasma and urine.
A fluorescence method is presented for the determination of nitrofurantoin based on conversion of the drug to a fluorescent substance. The method requires 0.1-0.5 ml of plasma or diluted urine and is 10 times more sensitive than the commonly used colorimetric method.
D000814:Aniline Compounds; D000818:Animals; D003124:Colorimetry; D009582:Nitrofurantoin / Q000032:analysis* / Q000097:blood / Q000652:urine; D011817:Rabbits; D013050:Spectrometry, Fluorescence; D013438:Sulfhydryl Compounds
D000814:Aniline Compounds; D013438:Sulfhydryl Compounds; C005464:2-aminothiophenol; D009582:Nitrofurantoin