Protracted analgesia in young and adult rats maternally exposed to methadone.
The analgesic response to the hot-plate test was studied in 21-, 45-, 60-, 120- and 300-day-old rats maternally exposed to methadone (5 mg/kg). An elevation in nociceptive threshold, in the absence of further exposure to methadone, was observed in young and adult rats perinatally subjected to methadone.
D000367:Age Factors; D000698:Analgesia; D000818:Animals; D005260:Female; D008297:Male; D008431:Maternal-Fetal Exchange; D008691:Methadone / Q000009:adverse effects / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
D008691:Methadone