title: [Tissue distribution of 14C-tetroxoprim in the rat (author's transl)].
abstract: The distribution of i.v. injected and orally administered 2,4-diamino-5-[3,5-dimethoxy-4-(2-methoxyethoxy)]-benzylpyrimidine (2-14C-tetroxoprim) was studied in the whole body of rats using autoradiographic techniques. Quantitative measurements of tissue levels at various times confirmed the autoradiographic data. After shorter survival times higher activity concentrations were found in the liver, kidneys, lung and stomach. The radioactive affinity of the kidneys appears to be much higher in the medullary than in the cortical zone. After longer survival times, the 14C-radioactivity is mainly localized in the digestive system.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000378:metabolism*; D001345:Autoradiography; D007275:Injections, Intravenous; D007408:Intestinal Absorption; D008297:Male; D011743:Pyrimidines / Q000008:administration & dosage / Q000378:metabolism*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D000890:Anti-Infective Agents; D011743:Pyrimidines; C023507:tetroxoprim
vernacular_title: Untersuchungen zur Gewebeverteilung von 14C-Tetroxoprim bei der Ratte.