Estrogen receptor protein in malignant carcinoid tumor: a report of 2 cases.
Two cases of metastatic malignant carcinoid tumor in elderly women contained significant amounts of estrogen receptor (19 and 32 femtomoles/mg protein) as shown by Scatchard-plot analysis of a dextran-coated charcoal assay, inhibition of binding by an estrogen analog (67 and 63%) and high-affinity binding (Kd = 6.8 and 2.6 x 10(-10) M). The demonstration of estrogen receptor in malignant carcinoid tumor expands the spectrum of non-breast or non-gynecologic neoplasms that contain the receptor. The significane of estrogen receptor in such tumors is uncertain; it may represent aberrant derepression of the gene for estrogen receptor protein in a malignant tumor.
D000368:Aged; D002276:Carcinoid Tumor / Q000378:metabolism* / Q000473:pathology / Q000556:secondary; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000378:metabolism; D008113:Liver Neoplasms / Q000378:metabolism; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism*; D011960:Receptors, Estrogen / Q000235:genetics / Q000378:metabolism*; D013489:Suppression, Genetic
D011960:Receptors, Estrogen; D004958:Estradiol