Effects of oestrogens on erythrocyte enzyme efflux in normal men and women.
In the normal female range for serum creatine kinase, the large diminutions associated with the reproductive period and with pregnancy are apparently related to oestrogen production. Specimens of heparinised blood from healthy men and women were stressed by chilling, and showed the predictably large efflux of erythrocyte aldolase and lactate dehydrogenase into plasma. In aliquots of the same specimens simultaneously stressed in the same way, previous substitution of the natural plasma with pregnant plasma rich in oestrogens gave a marked significant reduction in the efflux of both enzymes in women, but not in men. The significance of these findings is discussed.
D000293:Adolescent; D000328:Adult; D003080:Cold Temperature; D003402:Creatine Kinase / Q000097:blood; D004912:Erythrocytes / Q000201:enzymology*; D004967:Estrogens / Q000494:pharmacology*; D005260:Female; D005634:Fructose-Bisphosphate Aldolase / Q000097:blood*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011247:Pregnancy; D012737:Sex Factors
D004967:Estrogens; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D005634:Fructose-Bisphosphate Aldolase