The nature of secretory agglutinins and aggregating factors. IV. Complexing between non-mucin glycoproteins, immunoglobulins and mucins in human saliva and amniotic fluid.
By themselves the non-mucin glycoproteins of saliva and amniotic fluid produce secretory conglutinin-like factor (SKF) and secretory bacterial aggregating factor (SBAF) activity. These glycoproteins also bind immunoglobulins; a secretory binding factor for immunoglobulins (SBFI) with EDTA-reversible activity is found in amniotic fluid. Agglutination of particles by very small amounts of secretory antibody is facilitated by reversible and irreversible binding of antibody to SKF/SBAF active glycoproteins. EDTA effects on the carrier glycoproteins make the bound antibody activity EDTA-sensitive. The SKF/SBAF glycoproteins also have EDTA-sensitive interactions with each other and possibly with mucins. These complex interactions of secretory glycoproteins and immunoglobulins are of importance in mucosal protection.
D000373:Agglutinins; D000653:Amniotic Fluid / Q000276:immunology; D000818:Animals; D001667:Binding, Competitive; D002449:Cell Aggregation; D002846:Chromatography, Affinity; D003168:Complement Fixation Tests; D006023:Glycoproteins / Q000276:immunology*; D006801:Humans; D009077:Mucins / Q000276:immunology*; D009194:Myeloma Proteins / Q000276:immunology; D011817:Rabbits; D012463:Saliva / Q000276:immunology
D000373:Agglutinins; D006023:Glycoproteins; D009077:Mucins; D009194:Myeloma Proteins