Removal of internally deposited gold by 2,3-dimercaptopropane sodium sulphonate (Dimaval).
1 Orally administered 2,3-dimercaptopropane sodium sulphonate (DMPS, Dimaval) reduced the concentration of gold in rats treated with Auro-Detoxin and increased the urinary excretion of the metal. 2 In a long-term experiment, DMPS decreased significantly the concentration of gold in the kidneys and in the skin and increased it in plasma. 3 DMPS appears to be of interest as a possible antidote to gold, which could replace the more toxic 2,3-dimercaptopropanol (BAL).
D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology*; D004112:Dimercaprol / Q000031:analogs & derivatives*; D005243:Feces / Q000032:analysis; D006046:Gold / Q000378:metabolism* / Q000652:urine; D006050:Gold Radioisotopes; D008297:Male; D051381:Rats; D014018:Tissue Distribution; D014494:Unithiol / Q000494:pharmacology*
D002614:Chelating Agents; D006050:Gold Radioisotopes; D004112:Dimercaprol; D014494:Unithiol; D006046:Gold