The uptake of high density lipoprotein cholesteryl ester in the perfused rat liver.
The hepatic uptake of high density lipoprotein cholesteryl ester was determine in a nonrecycling isolated rat liver perfusion. High density lipoprotein rich in the E apoprotein (apoE) showed about 10 times more uptake of the ester on a single pass than the bulk of the high density lipoproteins rich in the A-I protein. The apoportein recoveries in the liver paralleled the ester for both lipoproteins. The uptake appeared to occur primarily in the hepatic parenchymal cell. Addition of human C-III-1 apoprotein to the rat apoE-rich high density lipoprotein inhibited the hepatic uptake of its constituents.
D000818:Animals; D001053:Apolipoproteins / Q000378:metabolism; D001692:Biological Transport; D002788:Cholesterol Esters / Q000378:metabolism*; D006801:Humans; D008075:Lipoproteins, HDL / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D051381:Rats
D001053:Apolipoproteins; D002788:Cholesterol Esters; D008075:Lipoproteins, HDL