Simultaneous GLC determination of clofibrate and clofibric acid in human plasma.
A simultaneous assay for the detection of clofibrate and its metabolite, clofibric acid [2-(p-chlorophenoxy)-2-methylpropionic acid], is described. This GLC method is rapid and does not require a derivatization step. It is sensitive to 1-microgram/ml levels of either compound in biological samples and can be used to characterize the in vivo conversion of clofibrate ester to the free acid.
D002849:Chromatography, Gas; D002994:Clofibrate / Q000031:analogs & derivatives* / Q000097:blood*; D002995:Clofibric Acid / Q000097:blood*; D006801:Humans; D006868:Hydrolysis
D002995:Clofibric Acid; D002994:Clofibrate