An improved apparatus for intragastric titration in the conscious dog.
An apparatus for automatic intragastric titration with on-line display of results has been described. The apparatus has been validated by titration of exogenous acid injected into the test meal in a reservoir and in vivo by assessing the secretory response of a dog with a gastric fistula to a test meal. A titration display unit provides a record of the secretory response both as a digital printout and a bar chart display. Cimetidine (2 mg kg-1h-1) significantly reduced the secretory response to a test meal.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology; D004285:Dogs; D004864:Equipment and Supplies; D005753:Gastric Mucosa / Q000378:metabolism; D006863:Hydrogen-Ion Concentration; D013270:Stomach / Q000032:analysis* / Q000502:physiology; D013997:Time Factors
D002927:Cimetidine