Cadmium-induced inhibition of zoxazolamine metabolism in male and female rats.
Pretreatment of rats with cadmium potentiates the duration of hexobarbital hypnosis and inhibits the rate of hepatic hexobarbital metabolism in male and female rats. In contrast, treatment with cadmium pe and female rats. Thus, sex-related differences in cadmium inhibition of hepatic drug metabolism is apparently substrate dependent.
D000818:Animals; D001711:Biotransformation; D002104:Cadmium / Q000494:pharmacology*; D003864:Depression, Chemical; D005260:Female; D008099:Liver / Q000201:enzymology; D008297:Male; D010243:Paralysis / Q000139:chemically induced; D051381:Rats; D013997:Time Factors; D015049:Zoxazolamine / Q000378:metabolism*
D002104:Cadmium; D015049:Zoxazolamine