The antiinflammatory activity of analogs of indomethacin correlates with their inhibitory effects on phospholipase A2 of rabbit polymorphonuclear leukocytes.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D007192:Indenes / Q000494:pharmacology*; D009504:Neutrophils / Q000201:enzymology*; D010740:Phospholipases / Q000037:antagonists & inhibitors*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D011817:Rabbits; D013329:Structure-Activity Relationship; D013467:Sulindac / Q000031:analogs & derivatives / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D007192:Indenes; D013467:Sulindac; C025462:sulindac sulfide; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2; C025463:sulindac sulfone