In vivo and in vitro studies on the early embryonic lethal tail-short (Ts) in the mouse.
An histological study reveals that embryos homozygous for the mutation tail-short (Ts) become abnormal as morulae, although a small amount of cell division may continue to take place during the following day. Homozygotes can be identified at 3 1/2 days post coitum (p.c.) by several criteria including low cell number, absence of cavitation, and weak cytoplasmic staining with haematoxylin. A similar pattern of developmental arrest is exhibited during culture, although an initial degree of cavitation occurs more frequently.
D000818:Animals; D004622:Embryo, Mammalian / Q000502:physiology*; D005804:Genes, Lethal; D006720:Homozygote; D066298:In Vitro Techniques; D051379:Mice; D008807:Mice, Inbred BALB C / Q000196:embryology*; D008817:Mice, Mutant Strains / Q000196:embryology; D013997:Time Factors