title: The role of methionine and vitamin B12 in folate incorporation by rat liver.
abstract: The decreased folate uptake induced by exposure of rats to nitrous oxide can be partly reversed by methionine supplementation. This is consistent with the theory that N2O inhibits methylcobalamin-dependent methionine synthetase (EC 2.1.1.13) in rat liver and previous observations showing decreased folate incorporation in rats made nutritionally vitamin B12 deficient.
mesh_terms: D000818:Animals; D005492:Folic Acid / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008715:Methionine / Q000494:pharmacology / Q000502:physiology*; D009609:Nitrous Oxide; D051381:Rats; D014805:Vitamin B 12 / Q000502:physiology*; D014806:Vitamin B 12 Deficiency / Q000139:chemically induced / Q000378:metabolism
chemical_list: D005492:Folic Acid; D008715:Methionine; D009609:Nitrous Oxide; D014805:Vitamin B 12