Pharmacokinetics of azlocillin in neonates.
The pharmacokinetics of the acylureido-penicillin, azlocillin, were studied after intravenous or intramuscular injections in 53 premature and full-term infants with infections. Effective concentrations wer" achieved in premature babies after doses of 50 mg/kg every 12 h and in full-term infants with 100 mg/kg every 12 h. No untoward effects of azlocillin were observed. On the basis of these studies, a dosage schedule for azlocillin has been established.
D001390:Azlocillin; D006207:Half-Life; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007700:Kinetics; D010406:Penicillins / Q000009:adverse effects / Q000378:metabolism*; D013997:Time Factors
D010406:Penicillins; D001390:Azlocillin