title: Overadditive chemotherapeutic synergism of prospidine and inosine when given sequentially to the Sarcoma 180 implanted intramuscularly.
abstract: The chemotherapeutic effectiveness of prospidine monotherapy on the Sarcoma 180 implanted i.m. was compared with several prospidine/inosine combinations. The chemotherapeutic action of the combination was enhanced overadditively when inosine was given 6 h after prospidine. This particular combination caused not only a significant curative action and tumor inhibition as compared with prospidine monotherapy, but also decreased the toxic effects.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004334:Drug Administration Schedule; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D007288:Inosine / Q000008:administration & dosage* / Q000009:adverse effects; D051379:Mice; D010879:Piperazines / Q000008:administration & dosage*; D011447:Prospidium / Q000008:administration & dosage* / Q000009:adverse effects; D012510:Sarcoma 180 / Q000188:drug therapy*
chemical_list: D010879:Piperazines; D007288:Inosine; D011447:Prospidium