Fat-soluble vitamin concentrations in hypercholesterolemic children treated with colestipol.
In summary: (1) Colestipol therapy plus diet reduced total cholesterol 19 +/- 3% in 11 hypercholesterolemic children after two months and 13 +/- 5% after two years in five children. (2) Diet therapy did not significantly reduce serum concentration of any of the fat-soluble vitamins or folate. (3) During 24 months of colestipol therapy plus diet serum vitamin A and E concentrations did decrease in the five patients with good drug adherence (vitamin A, 68 +/- 11 vs 35 +/- 4 microgram/100 ml, P less than .005) (vitamin E, 14 +/- 1 vs 11 +/- 1 microgram/ml, P less than .05). However, those concentrations remained within normal limits. (4) Colestipol therapy plus diet had no effect on prothrombin time, serum 25-hydroxycholecalciferol, folate, or calcium metabolism (as studied by sequential determination of serum total and ionized calcium phosphorus, alkaline phosphatase, and parathyroid hormone).
D000293:Adolescent; D002118:Calcium / Q000097:blood; D002648:Child; D002675:Child, Preschool; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D003084:Colestipol / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D005492:Folic Acid / Q000097:blood; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood; D006938:Hyperlipoproteinemia Type II / Q000097:blood* / Q000188:drug therapy; D007408:Intestinal Absorption / Q000187:drug effects*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D011073:Polyamines / Q000494:pharmacology*; D014801:Vitamin A / Q000097:blood; D014815:Vitamins / Q000097:blood*
D002791:Cholesterol, Dietary; D006887:Hydroxycholecalciferols; D008077:Lipoproteins, LDL; D011073:Polyamines; D014815:Vitamins; D014801:Vitamin A; D005492:Folic Acid; D003084:Colestipol; D002118:Calcium