Inhibition of tubulin assembly by ethylacetylacrylate, a sulfhydryl reagent and potential analog of cytochalasin A.
Ethyl acetylacrylate reacts rapidly with 2-mercaptoethanol and the sulfhydryl groups of tubulin. The structure of ethyl acetylacrylate resembles that of the reactive portion of cytochalasin A and potentially can serve as an analog of this antibiotic.
D000179:Acrylates / Q000494:pharmacology*; D003572:Cytochalasins / Q000494:pharmacology; D008623:Mercaptoethanol; D013438:Sulfhydryl Compounds; D013439:Sulfhydryl Reagents / Q000494:pharmacology*; D050257:Tubulin Modulators
D000179:Acrylates; D003572:Cytochalasins; D013438:Sulfhydryl Compounds; D013439:Sulfhydryl Reagents; D050257:Tubulin Modulators; D008623:Mercaptoethanol; C023438:ethylacetylacrylate