[Comparative evaluation of the protective action of nalorphine and pentazocine in acute morphine and promedol poisoning].
It was shown in experiments on white rats that the intensity of the antitoxic action of nalorphine (0.57 mg/kg) and pentazocin (3 mg/kg) is related to the chemical structure of a narcotic analgetic agent. This action is more clearly manifested during poisoning induced by the phenylpiperidine derivative promedol (LD50 33.33 mg/kg). Nalorphine increases LD50 of promedol and corrects of metabolic disturbances produced by promedol. Pentazocin does not compare favourably to nalorphine since it mostly acts as a stimulant of external respiration.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000208:Acute Disease; D000818:Animals; D050260:Carbohydrate Metabolism; D002395:Catecholamines / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D008614:Meperidine / Q000031:analogs & derivatives*; D009020:Morphine / Q000506:poisoning*; D009269:Nalorphine / Q000627:therapeutic use*; D010423:Pentazocine / Q000627:therapeutic use*; D011396:Promedol / Q000506:poisoning*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D002395:Catecholamines; D011396:Promedol; D009020:Morphine; D008614:Meperidine; D010423:Pentazocine; D009269:Nalorphine
Sravnitel'naia otsenka zashchitnogo deĭstviia nalorfina i pentazotsina pri ostroĭ intoksikatsii mrofinom i promedolom.