Cefaclor levels in human aqueous humor.
In an attempt to investigate penetration of cefaclor into human aqueous humor, we administered 500-mg and 1-g doses of cefaclor to 39 patients about to undergo cataract extraction. Average aqueous humor levels of 0.27, 0.27, and 0.17 microgram/mL were achieved at 1, 2, and 4 hours, respectively, after the 500-mg oral dose. After 1 g orally, we found average aqueous humor levels of 0.61, 0.64, 0.72, 0.4, and 0.31 microgram/mL at 1, 2, 3, 4, and 5 hours, respectively. Therapeutic levels in primary aqueous humor were consistently achieved against Streptococcus pneumoniae and St pyogenes, group A.
D001082:Aqueous Humor / Q000032:analysis*; D001681:Biological Assay; D002387:Cataract Extraction; D002433:Cefaclor / Q000032:analysis* / Q000494:pharmacology; D002506:Cephalexin / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D013210:Staphylococcus / Q000187:drug effects; D013296:Streptococcus pneumoniae / Q000187:drug effects; D013997:Time Factors
D002433:Cefaclor; D002506:Cephalexin