[Dopamine and renal homeostatic control of osmolarity and extracellular fluid volume in initial conditions of hydro-saline depletion and retention. I. Renal functional parameters].
Renal effects of dopamine (DA) infusion (0,1 micrograms.kg-1.min-1) in healthy human subject are strongly dependent on the basal condition of the extra-cellular fluid volume. The renal vasodilation and the inhibition of isosmotic sodium reabsorption (as % of sodium filtered load) induced by DA in hydro-saline retention are highly blunted in hydro-saline depletion. Moreover the inhibitory effect on anisosmotic sodium reabsorption (as % of sodium distal load), observed in hydro-saline retention, is reversed in hydro-saline depletion. Thus, DA is likely to behave as a sodium excretion regulator.
D000328:Adult; D001834:Body Water / Q000378:metabolism*; D004039:Diet, Sodium-Restricted; D004231:Diuresis / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology*; D005110:Extracellular Space / Q000502:physiology; D005260:Female; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D009994:Osmolar Concentration; D012965:Sodium Chloride / Q000378:metabolism*; D014868:Water Deprivation; D014882:Water-Electrolyte Balance
D012965:Sodium Chloride; D004298:Dopamine
Dopamina e controllo omeostatico renale dell'osmolarita' e del volume del liquido extracellulare in condizioni iniziali di deplezione e di ritenzione idro-salina. I) Parametri funzionali renali.