Haemodynamic effects of nicergoline in man at rest and during exercise.
1. The intravenous administration of nicergoline (5 mg) was followed by a rapid and sustained lowering of blood pressure; less rapid effects were bradycardia and an elevation of cardiac output. These delayed effects are consistent with an indirect action on the alpha-adrenoreceptors of the central nervous system. 2. Following the oral administration of nicergoline (30 mg), a partial reduction of exercise-induced lactacidaemia was demonstrated, which is consistent with the haemodynamic changes shown at rest.
D000284:Administration, Oral; D000328:Adult; D004873:Ergolines / Q000494:pharmacology*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D009530:Nicergoline / Q000008:administration & dosage / Q000494:pharmacology*; D005082:Physical Exertion; D012146:Rest; D013997:Time Factors
D004873:Ergolines; D009530:Nicergoline