title: Muscle respiratory capacity and fiber type as determinants of the lactate threshold.
abstract: This study examined the relationship between the respiratory capacity of an individual's skeletal muscle and the work rate at which blood lactate accumulation begins (lactate threshold). Comparisons were also made among fiber type, VO2max, and the lactate threshold. Muscle biopsies were taken from the vastus lateralis muscle for determination of respiratory capacity and fiber type (myosin ATPase). The lactate threshold was assessed in terms of both the absolute work rate (VO2) and relative work rate (%VO2max). The capacity of muscle homogenates to oxidize pyruvate was significantly (P less than 0.01) related to the absolute (r = 0.94) and relative (r = 0.83) lactate thresholds. Significant positive correlations (P less than 0.01) were also found between the percent of slow-twitch fibers and absolute (r = 0.74) and relative (r = 0.70) lactate thresholds. The results suggest that the muscle's respiratory capacity is of primary importance in determining the work rate at which blood lactate accumulation begins. They also suggest that the proportion of slow-twitch fibers may play an important role in determining the relative lactate threshold.
mesh_terms: D000328:Adult; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D008297:Male; D009119:Muscle Contraction; D009132:Muscles / Q000378:metabolism* / Q000502:physiology; D010101:Oxygen Consumption
chemical_list: D007773:Lactates