title: Oversized flagellar membrane protein in paralyzed mutants of Chlamydomonas reinhardrii.
abstract: A mutant strain of Chlamydomonas reinhardtii is shown to possess an oversized flagellar membrane protein. The mutant has paralyzed flagella, is temperature sensitive for flagellar assembly, and has an abnormal axonemal protein composition. All phenotypes appear to derive from a single Mendelian mutation, and genetic analysis suggests that the mutation, which call ts222, is in the gene pfl. Because pf1 mutants are known to have radial-spoke defects (Piperno et al., 1977, Proc. Natl. Acad. Sci. U. S. A. 74:1600-1604; and Witman et al., 1978, J. Cell Biol. 76:729-797), a relation as yet undefined appears to exist between radial-spoke and flagellar membrane biogenesis.
mesh_terms: D000483:Alleles; D002696:Chlamydomonas / Q000235:genetics* / Q000378:metabolism / Q000648:ultrastructure; D005407:Flagella / Q000502:physiology; D005808:Genes, Recessive; D008565:Membrane Proteins / Q000096:biosynthesis*; D009024:Morphogenesis; D009154:Mutation; D010940:Plant Proteins / Q000096:biosynthesis*; D013696:Temperature
chemical_list: D008565:Membrane Proteins; D010940:Plant Proteins