title: Comparative study of atropine and glycopyrrolate on suxamethonium-induced changes in cardiac rate and rhythm.
abstract: The effectiveness of atropine and glycopyrrolate in the prophylaxis of suxamethonium-induced bradycardia was evaluated in a double-blind study of 56 patients. Three had clinically demonstrable bradycardia, all having received atropine. We conclude that glycopyrrolate offered adequate protection against cardiac effects of repeated doses of suxamethonium.
mesh_terms: D000328:Adult; D001285:Atropine / Q000627:therapeutic use*; D001919:Bradycardia / Q000139:chemically induced / Q000503:physiopathology / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006024:Glycopyrrolate / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D011229:Preanesthetic Medication; D011759:Pyrrolidines / Q000627:therapeutic use*; D011897:Random Allocation; D013390:Succinylcholine / Q000009:adverse effects*
chemical_list: D011759:Pyrrolidines; D001285:Atropine; D013390:Succinylcholine; D006024:Glycopyrrolate