Morphological effects of mitomycin C administered intravesically to normal mice and mice with N-[4-(5-nitro-2-furyl)-2-thiazolyl]-formamide-induce bladder neoplasms.
The intravesical administration of mitomycin C to normal and N-[4-(5-nitro-2-furyl)-2-thiozolyl]formamide-induced bladder tumor-carrying mice at initial concentrations of 2 and 5 mg/ml for 2 hr resulted in marked morphological effects including cytoplasmic and nuclear abnormalities and disruption of surface architecture. Tumors cells and normal urothelial cells were sensitive to the effects of mitomycin C. These effects were limited to epithelial cells.
D000818:Animals; D004848:Epithelium / Q000187:drug effects; D005200:FANFT; D005260:Female; D051379:Mice; D008854:Microscopy, Electron; D008937:Mitomycins / Q000008:administration & dosage*; D009374:Neoplasms, Experimental / Q000188:drug therapy; D013844:Thiazoles; D001743:Urinary Bladder / Q000187:drug effects* / Q000648:ultrastructure; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000648:ultrastructure
D008937:Mitomycins; D013844:Thiazoles; D005200:FANFT