title: Simultaneous high-performance liquid chromatographic determination of chlordiazepoxide and amitriptyline hydrochloride in two-component tablet formulations.
abstract: A rapid, precise, and accurate high-performance liquid chromatographic procedure is presented for the stimultaneous determination of amitriptyline hydrochloride and chlordiazepoxide in two-component tablet formulations. The impurities and decomposition products of both components were separated, making the determination specific for amitriptyline hydrochloride and chlordiazepoxide. The method was used for the assay, content uniformity, and dissolution testing of dosage forms containing 5--30 mg of chlordiazepoxide and 12.5--75 mg of amitriptyline.
mesh_terms: D000639:Amitriptyline / Q000032:analysis*; D002707:Chlordiazepoxide / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D012995:Solubility; D013607:Tablets / Q000032:analysis
chemical_list: D004338:Drug Combinations; D013607:Tablets; D000639:Amitriptyline; D002707:Chlordiazepoxide