title: Rifampin in the management of early prosthetic staphylococcus epidermidis endocarditis.
abstract: Staphylococcus epidermidis endocarditis occurred four days following aortic valve replacement with a Björk-Shiley prosthesis. Antimicrobial therapy, shown to be effective by in vitro and in vivo studies, failed to eradicate the infection. When rifampin was added to the existing antibiotic regimen, peak serum bactericidal activity increased, the patient defervesced, and blood cultures became negative.
mesh_terms: D000328:Adult; D001021:Aortic Valve / Q000601:surgery*; D004697:Endocarditis, Bacterial / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006350:Heart Valve Prosthesis; D006801:Humans; D011183:Postoperative Complications / Q000188:drug therapy*; D012293:Rifampin / Q000627:therapeutic use*; D013203:Staphylococcal Infections / Q000188:drug therapy*
chemical_list: D012293:Rifampin