Patient survival factors in paranasal sinus mucormycosis.
Analysis of 170 cases of paranasal sinus mucormycosis collected from the literature and 9 cases of our own revealed a 50% mortality for this disease. When analyzed according to decade, survival has increased to 70% in the cases reported from 1970-1979. There were no significant differences between the survivors and the fatalities when evaluated according to age, sex, laterality, or radiographic findings. There was a markedly poorer prognosis for those patients with hemiplegia, facial necrosis, and nasal deformity. The underlying disease was an important determinant of survival: 75% of patients with no systemic disease, 60% of diabetics, and 20% of patients with other disorders survived. Surgical debridement or radical resection and the use of amphotericin B significantly increased survival. Their combination further enhanced survival, especially in the diabetic.
D000293:Adolescent; D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality* / Q000628:therapy; D009519:New York City; D010254:Paranasal Sinus Diseases / Q000150:complications / Q000000981:diagnostic imaging / Q000401:mortality* / Q000628:therapy; D010256:Paranasal Sinuses / Q000000981:diagnostic imaging / Q000601:surgery; D011379:Prognosis; D011859:Radiography
D000666:Amphotericin B