title: Iridium implants in treatment of anorectal carcinoma.
abstract: A technique is described for the use of iridium-192 implants, combined with external irradiation, in the treatment of primary anorectal malignancy. The method allows large doses of radiation to the primary growth, regional infiltration and extensions, with much lower doses to the surrounding normal tissues and organs. Acceptable criteria for conservative local treatment of selected primary anorectal carcinomas are established. For the poor risk patient, the patient who refuses operation, and those having primary or recurrent carcinoma with distant metastases, this method of treatment offers maximum benefit, palliation, and acceptable complication rates. With judicious selection of patients and careful attention to volume of tissue treated, total dose, and fractionalization, serious complications should be substantially reduced.
mesh_terms: D000368:Aged; D001005:Anus Neoplasms / Q000532:radiotherapy*; D001918:Brachytherapy / Q000009:adverse effects; D003967:Diarrhea / Q000209:etiology; D005260:Female; D006801:Humans; D007495:Iridium / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000209:etiology; D011868:Radioisotopes / Q000627:therapeutic use; D012004:Rectal Neoplasms / Q000532:radiotherapy*
chemical_list: D011868:Radioisotopes; D007495:Iridium