Hypochloremic metabolic alkalosis following tolazoline-induced gastric hypersecretion.
Gastric hypersecretion following administration of tolazoline resulted in severe hypochloremic alkalosis in an infant with persistent fetal circulation. An initial bolus injection of 2 mg/kg was followed by an infusion of 5 mg/kg/hr for 24 hours. The infusion was then maintained at 2 mg/kg/hr for the next four days. Volume of gastric secretions exceeded 25 ml/kg/24 hr. Weaning from tolazoline and replacement of chloride and potassium corrected the metabolic alkalosis.
D000471:Alkalosis / Q000139:chemically induced* / Q000150:complications / Q000378:metabolism; D002712:Chlorides / Q000097:blood*; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D010547:Persistent Fetal Circulation Syndrome / Q000150:complications / Q000188:drug therapy / Q000378:metabolism; D014043:Tolazoline / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use
D002712:Chlorides; D014043:Tolazoline