Failure of a large dose of vitamin A to enhance the antibody response to tetanus toxoid in children.
Field studies to determine the effects of a large dose of water miscible vitamin A on selected parameters of children's immunological function were completed in rural Bangladesh. There was no difference between vitamin A treated or control groups in tetanus antitoxin responses after tetanus toxoid immunization or in skin test reactivity to common antigens. Subsequent studies with mice demonstrated vitamin A dose-related antitoxin responses, but the animals required amounts of vitamin that would be likely cause undesirable side effects if administered in similar doses to children.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001459:Bangladesh; D002648:Child; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007223:Infant; D007428:Intradermal Tests; D051379:Mice; D013745:Tetanus Toxoid / Q000276:immunology*; D014801:Vitamin A / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*
D013745:Tetanus Toxoid; D014801:Vitamin A