The effect of two new peptide antibiotics, the hypelcins, on mitochondrial function.
The action on mitochondria of 3 peptide antibiotics, hypelcin-A, hypelcin-B, and alamethicin, was examined. The results showed that they are unique uncouplers of oxidative phosphorylation, with the same mechanism of action.
D000408:Alamethicin / Q000031:analogs & derivatives / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D005033:Ethylmaleimide / Q000494:pharmacology; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D009840:Oligomycins / Q000494:pharmacology; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats; D014475:Uncoupling Agents
D000900:Anti-Bacterial Agents; D009840:Oligomycins; D014475:Uncoupling Agents; D000408:Alamethicin; C025478:hypelcin A; C025479:hypelcin B; D005033:Ethylmaleimide