[Activity of total serum creatine phosphokinase and its MB fraction in reversible coronary blood flow disorders in dogs in a chronic experiment].
On a model of reversible coronary blood flow disturbances in dogs short-term myocardial ischemia (2 to 15 min) in 16 chronic experiments caused an increase in the activity of total blood CPK by 57.3 +/- +/- 11.7 mE/ml (p less than 0.001) and of MB fraction by 6.9 +/- 1.23 mE/ml (p less than 0.001). Experiments in which the disturbances in coronary blood flow were repeated at intervals of 2-3 days showed that the changes in the activity of the enzymes occurred in definite stages. The results obtained on this model present new possibilities for elaborating diagnostic criteria of microfocal myocardial lesions.
D000818:Animals; D002908:Chronic Disease; D003327:Coronary Disease / Q000201:enzymology*; D003402:Creatine Kinase / Q000097:blood*; D004285:Dogs; D004789:Enzyme Activation; D007527:Isoenzymes; D009206:Myocardium / Q000201:enzymology; D013997:Time Factors
D007527:Isoenzymes; D003402:Creatine Kinase
Aktivnost' obshcheĭ syvorotochnoĭ kreatinfosfokinazy i ee fraktsii pri obratimykh narusheniiakh venechnogo krovotoka u sobak v khronicheskom opyte.