[Administration route of natural sex steroids (estradiol, progesterone, testosterone) (author's transl)].
The natural sex steroids (E2, T, P) may be used in therapeutics. Estradiol and testosterone esters (decanoate and undecanoate) may be administered orally. A local effect always follows the percutaneous application of sex steroids, and this is usually accompanied by a systemic effect. But because of the very important metabolism of progesterone by the skin, it is necessary to administer it by other routes (intravaginal, intrarectal) in order to obtain a systemic effect.
D000284:Administration, Oral; D000287:Administration, Topical; D004951:Esterification; D004958:Estradiol / Q000008:administration & dosage* / Q000378:metabolism; D005260:Female; D006801:Humans; D011374:Progesterone / Q000008:administration & dosage* / Q000378:metabolism; D012007:Rectum; D013739:Testosterone / Q000008:administration & dosage* / Q000378:metabolism; D014621:Vagina
D013739:Testosterone; D011374:Progesterone; D004958:Estradiol
Les voies d'administration des stéroïdes sexuels naturels (estradiol, progestérone, testostérone).