Enhancement by caffeine of the frequency of anaphase-telophase chromatin bridges induced by triethylenemelamine (TEM).
Treatment of BHK cells for 8 h with triethylenemelamine (TEM) followed by caffeine for 4 or 8 h, increased the frequency of anaphase-telophase chromatin bridges in relation to controls and TEM-treated cells. These results indicate that TEM-induced chromosome lesions detected as chromatin bridges at anaphase-telophase could be potentiated by caffeine.
D000705:Anaphase / Q000187:drug effects; D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D002453:Cell Cycle / Q000187:drug effects*; D002478:Cells, Cultured; D002843:Chromatin / Q000187:drug effects; D002869:Chromosome Aberrations; D006224:Cricetinae; D007668:Kidney; D013692:Telophase / Q000187:drug effects; D014265:Triethylenemelamine / Q000494:pharmacology*
D002843:Chromatin; D002110:Caffeine; D014265:Triethylenemelamine