title: Attempts at use of strychnine sulfate in the treatment of nonketotic hyperglycinemia.
abstract: In two cases of nonketotic hyperglycinemia treated from early ages with strychnine sulphate, the patients demonstrated persistent severe psychomotor retardation and seizures. Strychnine therapy improved tone and feeding, but did not seem to alter fundamentally the course of the disease in either patient.
mesh_terms: D000592:Amino Acid Metabolism, Inborn Errors / Q000150:complications / Q000188:drug therapy* / Q000473:pathology; D001921:Brain / Q000473:pathology; D005998:Glycine / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000209:etiology; D008297:Male; D011596:Psychomotor Disorders / Q000209:etiology; D013331:Strychnine / Q000627:therapeutic use*
chemical_list: D013331:Strychnine; D005998:Glycine