[Ca-accumulating capacity of the cell membranes of the myocardium and smooth musculature in rats with spontaneous genetic hypertension].
The features of calcium binding and accumulation by the membrane fractions of the myocardium, aorta, and uterus of rats with spontaneous genetic hypertension (SHR) were studied by the method of radioisotope exchange. A decrease in the Ca-accumulating capacity of the reticulum and increase in that of the mitochondria of the SHR myocardium as compared to the Ca-accumulating property of the myocardial fractions of rats with normal arterial pressure were demonstrated. The changes in intracellular accumulation of calcium in the SHR aorta are linked with the membranes of the sarcolemma in which the ATP-dependent and ATP-independent binding of calcium was found to be reduced. The membrane Ca-accumulating capacity was also found to be changed in cells of smooth muscles no exposed to the direct long-term effect of increased arterial pressure: the Ca-accumulating capacity of the mitochondria of the SHR uterus is 1.3-1.6 times less than that in animals with normal arterial pressure.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D005260:Female; D006973:Hypertension / Q000378:metabolism*; D007700:Kinetics; D008929:Mitochondria, Heart / Q000378:metabolism; D008931:Mitochondria, Muscle / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains; D012508:Sarcolemma / Q000378:metabolism; D012519:Sarcoplasmic Reticulum / Q000378:metabolism; D014599:Uterus / Q000378:metabolism
D002118:Calcium
Ca-akkumuliruiushchaia sposobnost' kletochnykh membran miokarda i gladkoĭ muskulatury krys so spontannoĭ geneticheskoĭ gipertenzieĭ.