[Effect of hydrazine sulfate on nucleic acid metabolism in rat liver tissue during the process of chemical hepatocarcinogenesis].
The development of hepatocellular tumors in rats would show the same character and was observed in the same period (6 months) after either simultaneous administration of a hepatocarcinogen--diethylnitrosoamine (0.02%) and a possible antitumor agent, namely hydrazine sulfate (0.012%) with drinking water, or after the administration of the hepatocarcinogen concerned alone. Hydrazine sulfate failed to reveal any anti-carcinogenic properties, but it would normalize the turnover rate of total RNA and its nuclear components in the rat liver tissue.
D000818:Animals; D004273:DNA, Neoplasm / Q000378:metabolism*; D004052:Diethylnitrosamine; D004353:Drug Evaluation, Preclinical; D006801:Humans; D006834:Hydrazines / Q000627:therapeutic use*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000188:drug therapy / Q000378:metabolism*; D012334:RNA, Neoplasm / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D004273:DNA, Neoplasm; D006834:Hydrazines; D012334:RNA, Neoplasm; D004052:Diethylnitrosamine
Vliianie gidrazinsul'fata na obmen nukleinovykh kislot tkani pecheni krys v protsesse khimicheskogo gepatokantserogeneza.