Footshock-induced rotation: lack of effect of haloperidol and AMPT.
Non-lesioned, drug naive rats were administered footshock to determine whether aversive stimuli would induce rotational behavior. Circling was produced at 1, 2 and 4 mA. The direction of circling was consistent upon retest. Circling was not blocked by either haloperidol or alpha-methyl-p-tyrosine (AMPT) and the direction of circling induced by shock was independent from that exhibited spontaneously during the 24 h prior to the test. These findings suggest that aversive-stimulus-induced circling is not mediated by the nigrostriatal dopamine system.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D004597:Electroshock; D005260:Female; D005528:Foot; D006220:Haloperidol / Q000494:pharmacology*; D008781:Methyltyrosines / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D051381:Rats; D012399:Rotation
D008781:Methyltyrosines; D000661:Amphetamine; D006220:Haloperidol