Distribution and excretion of 203Hg2+ in rats after unitiol, spironolactone and polythiol resin treatment.
Rats were given 203HgCl2 i.v. at a dose level of 120 microgram of Hg2+ per rat. The effect of unitiol (UNI; sodium 2, 3-dimercaptopropanosulphonate) and a combined UNI, spironolactone (SPL) and polythiol resin treatment on wholebody retention, organ distribution and excretion were studied for 48 h. In both treated groups significant increases in excretion and decreases in whole-body retention of 203Hg were observed. In the combination-treated group significantly lower values of 203Hg in plasma, kidney and brain were found.
D000818:Animals; D004112:Dimercaprol / Q000031:analogs & derivatives*; D004338:Drug Combinations; D005260:Female; D008628:Mercury / Q000378:metabolism* / Q000652:urine; D008630:Mercury Poisoning / Q000188:drug therapy; D051381:Rats; D012117:Resins, Synthetic / Q000494:pharmacology*; D013148:Spironolactone / Q000494:pharmacology*; D014018:Tissue Distribution; D014494:Unithiol / Q000494:pharmacology*
D004338:Drug Combinations; D012117:Resins, Synthetic; C024554:polythiol resin; D004112:Dimercaprol; D013148:Spironolactone; D014494:Unithiol; D008628:Mercury