Peristaltic dissolution apparatus: prediction of relative in vivo performance of prednisone tablets in humans.
By utilizing a previously established correlation concept, the relative in vivo performance in humans of seven unknown prednisone tablets was predicted accurately from peristaltic dissolution rate data. A general discussion is presented on the role of the peristaltic apparatus in selecting a suitable dosage form at the developmental stage.
D001682:Biological Availability; D002626:Chemistry, Pharmaceutical / Q000295:instrumentation; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D010528:Peristalsis; D011241:Prednisone / Q000378:metabolism*; D012995:Solubility; D013607:Tablets
D013607:Tablets; D011241:Prednisone