Low dose perphenazine and levodopa/carbidopa therapy in a patient with Parkinsonism and a psychotic illness.
Psychological morbidity is a common consequence of both Parkinson's disease and its treatment with antiparkinsonian agents. The authors describe an unusual case of a patient with Parkinson's disease and a psychosis who was treated with levodopa/carbidopa and very low dose perphenazine. The case raises the issue whether patients with profound psychological reactions to antiparkinson agents may be maintained on antiparkinsonian therapy by the addition of phenothiazines.
D002230:Carbidopa / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy*; D010546:Perphenazine / Q000627:therapeutic use*; D011618:Psychotic Disorders / Q000188:drug therapy*
D007980:Levodopa; D010546:Perphenazine; D002230:Carbidopa