Anticonvulsant activity of cyclopentano amino acids.
The hypothesis that certain amino acid analogues possessing a five-membered ring structure or amino acid analogues that can be viewed as fragments derived from such a ring would have anticonvulsant activity was proposed and tested. The compounds 1-aminocyclopentane carboxylic acid, 1-amino-3-methylcyclopentane carboxylic acid, 3-aminotetrahydrothiophene carboxylic acid, and alpha-aminoisobutyric acid were found to protect rats against seizures in the maximal electroshock test but offered no protection against metrazol- (pentylenetetrazol) induced seizures in mice. The structural feature of this class of anticonvulsants that allows for hydrophobic interactions at the receptor site is considered to be a major physical factor necessary in promoting the activity of this class of anticonvulsants.
D000596:Amino Acids / Q000627:therapeutic use*; D000621:Aminoisobutyric Acids / Q000627:therapeutic use; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage; D003515:Cycloleucine / Q000031:analogs & derivatives / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004597:Electroshock; D008297:Male; D051379:Mice; D010433:Pentylenetetrazole; D051381:Rats; D012640:Seizures / Q000139:chemically induced; D013329:Structure-Activity Relationship
D000596:Amino Acids; D000621:Aminoisobutyric Acids; D000927:Anticonvulsants; D003515:Cycloleucine; D010433:Pentylenetetrazole