[Effect of novocainamide on the course of experimental myocardial infarct with arrhythmias in rabbits].
Application of novocainamid in experimental myocardial infarction (EMI) in rabbits exerted a favourable effect on the heart excitability and conduction, preventing arrhythmias during the first experimental day. An immediate antiarrhythmic effect was observed in two rabbits with EMI complicated in one case by atrial fibrillation combined with ventricular extrasystole, and by the blockade of the left limb of His' bundle in the other one. At the same time an adverse effect elicited by novocainamide was recorded.
D000818:Animals; D000889:Anti-Arrhythmia Agents; D001145:Arrhythmias, Cardiac / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D005260:Female; D008297:Male; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy*; D011342:Procainamide / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D011342:Procainamide
Vliianie novokainamida na techenie éksperimental'nogo infarkta miokarda s aritmiiami u krolikov.