[Sigetin treatment of the developmental disorders induced in rabbit prenatal ontogeny by curtailment of the uteroplacental blood circulation].
About 40 per cent of the uterine preplacental vessels were ligated in rabbits on the 11th or 18th days of gestation. Some of the female rabbits operated upon were given 5 mg of intravenous sigetin twice a day till the end of pregnancy. Investigation of the progeny development, the ability of learning at an age of about 6 months, in particular, showed a somewhat better development and ability of learning in the offsprings of female rabbits receiving sigetin.
D000818:Animals; D001557:Benzenesulfonates / Q000627:therapeutic use*; D000013:Congenital Abnormalities / Q000188:drug therapy* / Q000209:etiology; D004353:Drug Evaluation, Preclinical; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005333:Fetus / Q000187:drug effects*; D007858:Learning / Q000187:drug effects; D008026:Ligation; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D011817:Rabbits; D012039:Regional Blood Flow; D014599:Uterus / Q000098:blood supply*
D001557:Benzenesulfonates; C001770:sigetin
Lechenie sigetinom narusheniĭ razvitiia, vyzvannykh v prenatal'nom ontogeneze krolikov sokrashcheniem matochno-platsentarnogo krovoobrashcheniia.