Vascular reactivity in hypertension: altered effect of ouabain.
Ouabain inhibits the relaxing effect of Ca2+ (but not of Mn2+) on contractile responses in tail artery strips isolated from spontaneously hypertensive and normotensive rats. The magnitude of ouabain inhibition was greater in vascular strips from hypertensive rats suggesting a significant difference in basic membrane function in hypertensive vascular smooth muscle.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006973:Hypertension / Q000503:physiopathology*; D008345:Manganese / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology / Q000503:physiopathology*; D010042:Ouabain / Q000494:pharmacology*; D051381:Rats
D008345:Manganese; D010042:Ouabain; D002118:Calcium