Prolonged biphasic response of plasma testosterone to single intramuscular injections of human chorionic gonadotropin.
The response of plasma testosterone to varying doses of hCG (0--6000 IU) given as a single im injection has been evaluated in normal men. After an initial rise at 2 h, the levels of testosterone demonstrated a secondary rise, reaching a peak 48 h after the im injection. The magnitude of the response varied directly with the dose of hCG used, and at the highest dose (6000 IU) testosterone levels were still elevated 6 days after administration. Plasma estradiol levels showed a dose-dependent rise, with peak levels being attained 24 h after hCG. The prolonged response of plasma testosterone to a single injection of hCG should prompt a reevaluation of diagnostic and therapeutic regimens using this agent.
D000328:Adult; D006063:Chorionic Gonadotropin; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D008297:Male; D013739:Testosterone / Q000097:blood*
D006063:Chorionic Gonadotropin; D013739:Testosterone