Elevated titers of the beta subunit of human chorionic gonadotropin in oophorectomized women being treated for trophoblastic disease.
Radioimmunoassay has shown a cross-reaction of the beta subunit of human chorionic gonadotropin (HCG) with high levels of luteinizing hormone (LH) in the serum of four women who underwent bilateral oophorectomy as part of their treatment for trophoblastic disease. Administration of oral contraceptives led to suppression of the LH and beta subunit HCG titers.
D000328:Adult; D002369:Castration; D006063:Chorionic Gonadotropin / Q000097:blood*; D003276:Contraceptives, Oral / Q000008:administration & dosage; D003429:Cross Reactions; D003609:Dactinomycin / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000097:blood* / Q000188:drug therapy; D007986:Luteinizing Hormone / Q000097:blood*; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D011247:Pregnancy; D014594:Uterine Neoplasms / Q000097:blood* / Q000188:drug therapy
D006063:Chorionic Gonadotropin; D003276:Contraceptives, Oral; D003609:Dactinomycin; D007986:Luteinizing Hormone; D008727:Methotrexate