A comparative study of the ototoxicity of gentamicin and gentamicin C1.
Dose-response experiments comparing the ototoxic liability of the aminoglycoside antibiotics gentamicin sulfate and gentamicin C1 sulfate were conducted on guinea pigs. Measures of cochlear electrophysiology, histology, and the pharmacokinetic disposition of the drugs in the plasma and perilymph were made. Electrophysiological and histological measures indicated that gentamicin is more ototoxic than is gentamicin C1.
D000818:Animals; D003055:Cochlear Microphonic Potentials / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004423:Ear / Q000187:drug effects* / Q000503:physiopathology; D005839:Gentamicins / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects
D005839:Gentamicins