[Dopamine and renal homeostatic control of osmolarity and extracellular fluid volume in initial conditions of hydro-saline depletion and retention. II. Relationship between the renal functional parameters].
In hydro-saline depletion dopamine (DA) infusion (0,1 microgram.kg-1.min-1) elicits different renal effects than it does in hydro-saline retention. It is suggested that in hydro-saline depletion DA activates, besides vasal DA receptors, also vasal and tubular adrenergic receptors. Such adrenergic activation, either direct or presynaptically mediated, can account for both the decrease in the hyperemic response and the increase in the anisosmotic sodium reabsorption.
D000328:Adult; D001834:Body Water / Q000378:metabolism*; D004039:Diet, Sodium-Restricted; D004231:Diuresis / Q000187:drug effects; D004298:Dopamine / Q000494:pharmacology*; D005110:Extracellular Space / Q000187:drug effects / Q000502:physiology; D005260:Female; D006706:Homeostasis; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000502:physiology*; D009994:Osmolar Concentration; D012965:Sodium Chloride / Q000378:metabolism*; D014868:Water Deprivation
D012965:Sodium Chloride; D004298:Dopamine
Dopamina e controllo omeostatico renale dell'osmolarita' e del volume del liquido extracellulare in condizioni iniziali di deplezione e di ritenzione idro-salina. II) Relazione tra i parametri funzionali renali.