title: The effect of age on the intravenous sodium glycocholate test.
abstract: The clearance of an injected dose of sodium glycocholate has been studied in a group of 23 control subjects who had no evidence of liver disease. A significant correlation was found between bile salt clearance and age. No significant difference was found between the bile salt clearance of male and female subjects. Data derived from a simple compartmental model indicated that decreased clearance of bile salt with age was not specifically related to degenerative changes in hepatocellular integrity, hepatic uptake of bile salts or bile flow.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000418:Albumins / Q000494:pharmacology; D005260:Female; D006000:Glycocholic Acid / Q000097:blood* / Q000378:metabolism; D006461:Hemolysis; D006801:Humans; D007700:Kinetics; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D013997:Time Factors; D014680:Veins
chemical_list: D000418:Albumins; D006000:Glycocholic Acid