Responsiveness of hypertensive subjects to prazosin.
1. Plasma drug levels and blood pressure changes produced by a single 2 mg oral dose of prazosin were determined in nine hypertensive patients. 2. Regression analysis showed that there was a high degree of correlation between plasma prazosin concentration and change in mean blood pressure. 3. There were marked differences between patients in their responsiveness to prazosin.
D001794:Blood Pressure / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D011224:Prazosin / Q000097:blood / Q000627:therapeutic use*; D011799:Quinazolines / Q000627:therapeutic use*; D013997:Time Factors
D011799:Quinazolines; D011224:Prazosin