title: Cytotoxic treatment in children with idiopathic nephrotic syndrome.
abstract: The purpose of this retrospective study was to investigate the therapeutic value of steroids and cytotoxics in children with idiopathic nephrotic syndrome which developed during the period 1968-1977. Thirty-eight patients were followed. They were divided into three morphological groups based on renal biopsy findings, i.e., minimal changes (MCNS, n = 34), focal segmental glomerulosclerosis (FSGS, n=2) and atypical undefined changes (Undef., n=2). In the latter two groups therapy was less successful than in the MCNS-group. This study conclusively demonstrates that cytotoxic therapy is of value in prolonging the duration of the remission and increasing the responsiveness to steroids in children with MCNS.
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002648:Child; D002699:Chlorambucil / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007668:Kidney / Q000473:pathology; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D011239:Prednisolone / Q000627:therapeutic use; D012008:Recurrence
chemical_list: D000970:Antineoplastic Agents; D002699:Chlorambucil; D003520:Cyclophosphamide; D011239:Prednisolone