Radiation protection of pronormoblasts and normoblasts by 2-mercaptopropionylglycine (MPG).
The pronormoblasts and normoblasts in Swiss albino mice were found to be very sensitive to radiation and their percentage was reduced drastically after exposure to gamma-rays. The degree of damage increased with increase in radiation dose. MPG reduced the initial damage and brought about an early and fast recovery. It is concluded that the drug protects the stem cells and thereby reduces the depletion of the regenerating pool which causes a more efficient and accelerated recovery.
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D004900:Erythroblasts / Q000187:drug effects / Q000528:radiation effects*; D004912:Erythrocytes / Q000528:radiation effects*; D007700:Kinetics; D008297:Male; D051379:Mice; D008625:Tiopronin / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D008625:Tiopronin