The effect of caerulein on epithelial growth in the mouse gall bladder.
Caerulein, a synthetic decapeptide, was injected into mice in order to study its effect on DNA-synthesis activity in the gall bladder epithelium. Histoautoradiography after the injection of labeled thymidine was used. Higher labeling indices were observed at 8, 12, 12 and 24 h after caerulein injection. These data indicate that caerulein, apart from its cholecystokinetic effects, exerts a trophic effect on the gall bladder mucosa.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002108:Ceruletide / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D004848:Epithelium / Q000187:drug effects / Q000378:metabolism; D005704:Gallbladder / Q000187:drug effects / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL
D002108:Ceruletide; D004247:DNA