Effects of aluminium hydroxide on restraint-induced and restraint delay-induced gastric ulceration in rats.
Rats given aluminium hydroxide after cold-restraint stress but before the 'post-stress delay' period, ulcerated significantly less severely and less frequently than rats given the drug before cold-restraint stress or those given water at either time period. Both aluminium hydroxide treated groups exhibited less ulceration than non-drug groups. These data suggest profound parasympathetic and hence, gastric acid, involvement in restraint delay-induced ulceration in rats.
D000536:Aluminum Hydroxide / Q000494:pharmacology*; D000818:Animals; D000863:Antacids / Q000494:pharmacology; D003080:Cold Temperature; D005750:Gastric Juice / Q000378:metabolism; D008297:Male; D051381:Rats; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications; D013997:Time Factors
D000863:Antacids; D000536:Aluminum Hydroxide