title: Sulfhydryl group modulation and triiodothyronine generation in the human polymorphonuclear leukocyte.
abstract: The induction of phagocytosis in the human polymorphonuclear leukocyte and the attendant decrease in endogenous sulfhydryl group content were accompanied by a depression of the generation by the 27,000 x g particulate fraction of L-T3 and L-rT3 from substrate L-T4. A direct correlation between endogenous sulfhydryl group content and L-T3-generating activity was found to exist. The inhibitory influence of phagocytosis was prevented when phagocytosis was induced in the presence of a sulfhydryl group protector.
mesh_terms: D004229:Dithiothreitol / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D010587:Phagocytosis; D013438:Sulfhydryl Compounds / Q000097:blood*; D014284:Triiodothyronine / Q000097:blood*; D014285:Triiodothyronine, Reverse / Q000097:blood
chemical_list: D013438:Sulfhydryl Compounds; D014284:Triiodothyronine; D014285:Triiodothyronine, Reverse; D004229:Dithiothreitol