[Tissue fibrinolytic activity of different sections of the heart in sympathectomized animals].
In the heart of intact rats aged 6 and 10 weeks the activity of nonenzymatic fibrinolysis was found to be maximum in the auricular tissue. In partly sympathectomized (destruction of 75% of neurons in the ganglia) 10-week-old rats fibrinolytic activity was sharply reduced in the auricular tissue, and in the atrial and ventricular myocardium. The content of the plasminogen activator in all parts of the heart decreased to zero value. In stress situations 50% of the rats die from thrombi in the atrial cavity. In partly sympathectomized 10-week-old rats (characterized by restoration of peripheral sympathetic innervation) the studied parameteres were normalized. The fibrinolytic potential of the heart tissue was markedly decreased in totally sympathectomized rats (destruction of more than 99.5% of the neurons); under the effect of stress 80% of these animals died.
D000818:Animals; D000831:Animals, Newborn; D005342:Fibrinolysis; D006145:Guanethidine / Q000494:pharmacology; D006321:Heart / Q000503:physiopathology*; D006325:Heart Atria / Q000503:physiopathology; D006352:Heart Ventricles / Q000503:physiopathology; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010958:Plasminogen / Q000378:metabolism; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects*; D013997:Time Factors
D010958:Plasminogen; D006145:Guanethidine
Fibrinoliticheskaia aktivnost' tkaneĭ razlichnykh otdelov serdtsa u desimpatizirovannykh zhivotnykh.