Lithium therapy of canine cyclic hematopoiesis.
Treatment of cyclic hematopoiesis in the grey collie dog with lithium carbonate eliminated the recurrent neutropenia and normalized the other blood cell counts. These findings suggest that human cyclic hematopoiesis may be successfully treated with lithium. The effects of lithium on the monocytes, platelets, and reticulocytes, as well as the neutrophils, suggest that lithium operates on basic regulatory mechanisms affecting the most primitive hematopoietic precursor cells.
D000818:Animals; D001772:Blood Cell Count; D001854:Bone Marrow Cells; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004731:Endotoxins / Q000008:administration & dosage; D006400:Hematocrit; D006402:Hematologic Diseases / Q000188:drug therapy / Q000662:veterinary*; D006410:Hematopoiesis / Q000187:drug effects; D006412:Hematopoietic Stem Cells / Q000503:physiopathology*; D008094:Lithium / Q000627:therapeutic use*; D008938:Mitosis; D009503:Neutropenia / Q000188:drug therapy; D009504:Neutrophils; D010507:Periodicity; D012156:Reticulocytes
D004731:Endotoxins; D008094:Lithium