title: Biochemistry of metalocenes. The organ distribution of hydroxyacetyl [103Ru]ruthenocene and its glucuronide in mice.
abstract: Hydroxyacetyl [103Ru]ruthenocene and its o-glucuronide were prepared in vitro by incubation of acetyl [103Ru]ruthenocene with rat-liver homogenate, NADPH, and UDP-glucuronate. The factors affecting hydroxylation and glucuronidation in vitro were optimized for acetylruthenocene. Hydroxyacetyl [103Ru]ruthenocene glucuronide showed no affinity for the adrenal glands, but after i.v. administration of hy droxyacetyl [103Ru]ruthenocene there was a distinct accumulation of Ru-103 in adrenals, similar to that found after administration of acetyl [103Ru]ruthenocene.
mesh_terms: D000311:Adrenal Glands / Q000000981:diagnostic imaging* / Q000378:metabolism; D000818:Animals; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D008297:Male; D051379:Mice; D009942:Organometallic Compounds / Q000096:biosynthesis / Q000378:metabolism*; D011868:Radioisotopes; D011877:Radionuclide Imaging; D051381:Rats; D012428:Ruthenium / Q000378:metabolism; D014018:Tissue Distribution
chemical_list: D005965:Glucuronates; D009942:Organometallic Compounds; D011868:Radioisotopes; D012428:Ruthenium