Principles of clinical trials. Ludwig Breast Cancer Study Group.
Proper design and conduct of a clinical trial requires the consideration of a set of principles. These principles include the collaborative effort, consideration of both a medical and a statistical plan, and development of a data network. The Ludwig Breast Cancer Study Group with international participants has been formed according to these principles. This represents an approach to clinical trials which is designed to maximize the scientific pay-off. The goal is to determine the optimal treatment for every identifiable prognostic subgroup of patients.
D000328:Adult; D000970:Antineoplastic Agents / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000628:therapy; D002986:Clinical Trials as Topic / Q000379:methods*; D003625:Data Collection; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007391:International Cooperation; D008207:Lymphatic Metastasis; D008593:Menopause; D008875:Middle Aged; D012107:Research Design; D013629:Tamoxifen / Q000008:administration & dosage
D000970:Antineoplastic Agents; D013629:Tamoxifen