title: Analgesic and anti-inflammatory activity in alcoholic extracts of Cucumis trigonus Roxburghii. A preliminary communication.
abstract: Alcoholic extract of Cucumis trigonus was studied for analgesic activity by tail clip method in mice with pethidine hydrochloride as standard drug and by hydrochloric acid-induced writhing in mice using sodium salicylate as standard drug for comparison. ED50 of the extract was found to be 2.5 +/- 1.9 and 2.5 +/- 1.7 mg/kg in the two methods, respectively. Anti-inflammatory activity was studied in carrageenin-induced oedema and cotton pellet-induced granuloma using phenylbutazone as a standard drug for comparison. In both the methods the extract exhibited statistically significant activity.
mesh_terms: D000700:Analgesics; D000818:Animals; D000893:Anti-Inflammatory Agents; D055598:Chemical Phenomena; D002621:Chemistry; D004487:Edema / Q000139:chemically induced; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010653:Phenylbutazone / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology* / Q000633:toxicity; D010946:Plants, Medicinal; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000700:Analgesics; D000893:Anti-Inflammatory Agents; D010936:Plant Extracts; D010653:Phenylbutazone