Adverse reactions associated with ticrynafen use.
Three hypertensive patients receiving ticrynafen, a new uricosuric diuretic, experienced adverse reactions. One patient experienced acute renal failure, the second experienced a renal stone, and the third had a fatal hemorrhage while receiving anticoagulation therapy with warfarin sodium. All complications can be explained by known actions of the drug and are preventable. However, these reactions illustrate the potential hazards from widespread substitution of ticrynafen for thiazide diuretics in the treatment of hypertension.
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000328:Adult; D000368:Aged; D004357:Drug Synergism; D006016:Glycolates / Q000009:adverse effects*; D006470:Hemorrhage / Q000139:chemically induced*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy; D007669:Kidney Calculi / Q000139:chemically induced*; D008297:Male; D013989:Ticrynafen / Q000009:adverse effects*; D014527:Uric Acid / Q000652:urine; D014859:Warfarin / Q000009:adverse effects
D006016:Glycolates; D014527:Uric Acid; D014859:Warfarin; D013989:Ticrynafen