Effects of propranolol on post-ischemic acute renal failure.
The effects of constant intravenous infusion of propranolol, 1 mg/kg/h, on acute renal failure produced by 1 h occlusion of the left renal artery in the rat were investigated by clearance and micropuncture techniques. Propranolol infusion resulted in a significantly smaller rise in proximal intratubular pressure than that observed following renal ischemia in the saline-infused group. When compared with saline-infused animals, this effectwas accompanied by a significant improvement in inulin clearance without commensurate increase in renal blood flow or stop flow pressure and suggests attenuation of intratubular obstruction by the drug. A complex metabolic effect may be involved.
D058186:Acute Kidney Injury / Q000209:etiology / Q000503:physiopathology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002196:Capillaries / Q000503:physiopathology; D006801:Humans; D006874:Hydrostatic Pressure; D007511:Ischemia / Q000150:complications*; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000098:blood supply; D007687:Kidney Tubules, Proximal / Q000503:physiopathology; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects
D011433:Propranolol