Domperidone, an extracerebral inhibitor of dopamine receptors, stimulates thyrotropin and prolactin release in man.
Domperidone, an extracerebral dopamine receptor antagonist, was given im to 12 normal subjects and to a group of patients with subclinical hypothyroidism to study its effect on PRL and TSH secretion. Domperidone induced in all subjects a quick and marked increment of serum PRL. At 180 min, the levels remained high. A small but significant increase of TSH was also observed in normal as well as in hypothyroid subjects. Since domperidone does not cross the blood-brain barrier, the hormonal changes observed may be mediated through the pituitary and median eminence, tissues which lie outside of the blood-brain barrier.
D000328:Adult; D001562:Benzimidazoles; D004294:Domperidone; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood*; D007700:Kinetics; D008297:Male; D010880:Piperidines; D011388:Prolactin / Q000097:blood*; D011954:Receptors, Dopamine / Q000187:drug effects; D012016:Reference Values; D012737:Sex Factors; D013972:Thyrotropin / Q000097:blood*
D001562:Benzimidazoles; D010880:Piperidines; D011954:Receptors, Dopamine; D004294:Domperidone; D011388:Prolactin; D013972:Thyrotropin