Orotic acid prevents changes in cardiac sarcolemmal glycoproteins and contractility associated with muscular dystrophy in hamsters.
Orotic acid included in the diet of cardiomyopathic hamsters during the myolytic phase of the disease (30-60 days of age) prevented the reduction in cardiac sarcolemmal sialic acid, calcium binding, sialyltransferase activity and contractile activity associated with the cardiomyopathy.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006224:Cricetinae; D006023:Glycoproteins / Q000032:analysis*; D066298:In Vitro Techniques; D009137:Muscular Dystrophy, Animal / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000032:analysis*; D009963:Orotic Acid / Q000494:pharmacology* / Q000627:therapeutic use; D012508:Sarcolemma / Q000032:analysis; D012794:Sialic Acids / Q000032:analysis; D012799:Sialyltransferases / Q000032:analysis
D006023:Glycoproteins; D012794:Sialic Acids; D009963:Orotic Acid; D012799:Sialyltransferases; D002118:Calcium