Esophageal carcinoma in rats induced by N-amyl-N-methylnitrosamine.
N-Amyl-N-methylnitrosamine (AMN) induced esophageal carcinoma in Donryu strain rats when given in drinking water. The incidence of carcinomas was high when AMN was given as 0.0015% solution for 90 days or 0.003% solution for 60 days. There was no difference in the incidence in males and females. Sequential studies showed that 4-week administration was necessary to induce esophageal papillomas, and 8-week administration to induce esophageal carcinomas. Whole-body autoradiography after intravenous injection of N-amyl-N-methyl[14C]-nitrosamine (14C-AMN) indicated that AMN accumulated preferentially in the esophagus.
D000367:Age Factors; D000818:Animals; D001345:Autoradiography; D002273:Carcinogens / Q000378:metabolism / Q000633:toxicity*; D002277:Carcinoma / Q000139:chemically induced*; D004938:Esophageal Neoplasms / Q000139:chemically induced* / Q000473:pathology; D004947:Esophagus / Q000473:pathology; D005260:Female; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009602:Nitrosamines / Q000378:metabolism / Q000633:toxicity*; D010212:Papilloma / Q000139:chemically induced*; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D002273:Carcinogens; D009602:Nitrosamines; C025033:N-amyl-N-methylnitrosamine