Atropine nebulization--simple and safe.
Ten children with chronic perennial asthma received a single dose of atropine at approximately 0.075 mg/kg. The drug was compared to isoetharine and was delivered by a simple nebulizing system. Both drugs were noted to be effective bronchodilators as determined by FEV1 and MMEF responses. While isoetharine demonstrated an initial overall better effect at 30 minutes, atropine had a more sustained bronchodilatory action at three hours. No adverse effects were noted with either drug.
D000284:Administration, Oral; D000293:Adolescent; D001285:Atropine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D001993:Bronchodilator Agents; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D007528:Isoetharine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D008450:Maximal Midexpiratory Flow Rate
D001993:Bronchodilator Agents; D001285:Atropine; D007528:Isoetharine