Biochemical basis for evaluating oral contraceptives.
Oestrogens stimulate and increase HDL cholesterol concentration while progestogens decrease it; quite marked differences in effect on HDL can be demonstrated between the various oestrogen-progestogen combinations. Similar differences can be shown in their effect upon blood coagulation factors and upon the renin-angiotensin aldosterone axis. It is suggested that the selection of an oral contraceptive, in terms of cardiovascular risk, can be made from a consideration of comparative biochemical data.
D001779:Blood Coagulation Factors / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001798:Blood Proteins / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D003276:Contraceptives, Oral / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008075:Lipoproteins, HDL / Q000097:blood
D001779:Blood Coagulation Factors; D001798:Blood Proteins; D003276:Contraceptives, Oral; D008075:Lipoproteins, HDL; D002784:Cholesterol