title: Mineral metabolism in spinal cord injury.
abstract: In 10 paraplegic and 10 quadroplegic subjects, bone resorption was investigated by determining urinary excretion of hydroxyproline, calcium, and phosphorus. Measurements were performed weekly from the onset to 4 months after injury. During the first 7 weeks following injury, urinary excretion of calcium in paraplegic and quadriplegic subjects reached the highest level (380 +/- 180 mg/24hr). From 7 to 16 weeks after injury average urinary excretion of calcium (245 +/- 72 mg/24hr) remained significantly greater than that in controls (100 +/- 25 mg/24hr; p less than 0.05). Urinary hydroxyproline was elevated in paraplegic subjects (80 +/- 18 mg/24hr) for 8 weeks and in quadriplegic subjects (102 +/- 37 mg/24hr) for the entire 16 weeks following injury compared with that in controls (48 +/- 12 mg/24hr; p less than 0.05). Both paraplegic and quadriplegic subjects excreted more phosphorus (1.6 +/- 0.4 gm/24hr) than controls (0.85 +/- 0.2 gm/24hr; p less than 0.05) only during the first 2 weeks following spinal cord injury. During the acute phase of the injury (0-3 months), urinary excretion of calcium and magnesium was significantly higher (p less than 0.05) in subjects with complete compared with incomplete spinal cord lesions.
mesh_terms: D000328:Adult; D001862:Bone Resorption; D001842:Bone and Bones / Q000378:metabolism*; D002118:Calcium / Q000652:urine; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D008274:Magnesium / Q000652:urine; D008297:Male; D008903:Minerals / Q000652:urine*; D010024:Osteoporosis / Q000517:prevention & control; D010264:Paraplegia / Q000652:urine; D010758:Phosphorus / Q000652:urine; D011782:Quadriplegia / Q000652:urine; D013119:Spinal Cord Injuries / Q000652:urine*; D013997:Time Factors
chemical_list: D008903:Minerals; D010758:Phosphorus; D008274:Magnesium; D006909:Hydroxyproline; D002118:Calcium