Interaction between cadmium and phenobarbital on the activity of the hepatic microsomal monooxygenase system in the male rat.
Pretreatment of male rats with phenobarbital markedly stimulates, while treatment with cadmium inhibits, the activity of the hepatic microsomal monooxygenase enzyme system. When both agents were administered concomitantly, the stimulatory effect of phenobarbital and the inhibitory effect of cadmium cancelled each other.
D000818:Animals; D001711:Biotransformation; D002104:Cadmium / Q000494:pharmacology*; D004347:Drug Interactions; D006591:Hexobarbital / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D002104:Cadmium; D006591:Hexobarbital; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D010634:Phenobarbital