title: Serum levels and urinary excretion in humans of BL-S 578 (cefadroxil), a new semisynthetic cephalosporin.
abstract: Single doses of 250 and 500 mg of BL-S 578 (cefadroxil), a new semisynthetic cephalosporin, were orally administered to 13 normal, healthy volunteers and serum levels determined at timed intervals for 7 h. Peak concentration was obtained at 1 1/2 h after administration of 250 mg (8.981 micrograms/ml) or 500 mg (17.861 micrograms/ml). Urniary excretion levels within 24 h after ingestion of single doses of 250 and 500 mg of cefadroxil were 89.92 and 86.34%, respectively.
mesh_terms: D000328:Adult; D002434:Cefadroxil; D002506:Cephalexin / Q000031:analogs & derivatives* / Q000097:blood / Q000378:metabolism / Q000652:urine; D006801:Humans; D008297:Male; D013997:Time Factors
chemical_list: D002434:Cefadroxil; D002506:Cephalexin