Inhibitory effect of Urografin 76 on platelet function and thrombus formation in vascular catheters.
The effect of Urografin 76 on platelet aggregation and thrombus formation in vascular catheter was studied. In vitro experiments revealed that ADP-, epinephrine-, and collagen-induced platelet aggregation was significantly inhibited by Urografin 76 in concentrations greater than 0.3, 1, and 5% respectively. Rabbits that received 10 ml of Urografin 76 demonstrated a transient decrease in platelet aggregation for at least 3 minutes. Urografin 76 was apparently more effective than saline in preventing blood clot formation.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000502:physiology*; D002404:Catheterization / Q000009:adverse effects*; D003287:Contrast Media; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000494:pharmacology*; D006400:Hematocrit; D006801:Humans; D007455:Iodine / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D010976:Platelet Count; D011817:Rabbits; D013927:Thrombosis / Q000150:complications; D014652:Vascular Diseases / Q000150:complications
D003287:Contrast Media; D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D007455:Iodine