D-Penicillamine-induced Goodpasture's-like syndrome in primary biliary cirrhosis--successful treatment with plasmapheresis and immunosuppressives.
A 36-yr-old woman with primary biliary cirrhosis developed a Goodpasture's-like syndrome while on D-penicillamine treatment. She responded dramatically to plasmapheresis and immunosuppressive agents. Her illness was felt to be induced by D-penicillamine. This case illustrates the potential toxicity of D-penicillamine in primary biliary cirrhosis. We suggest that this drug be used only in controlled trials until efficacy is demonstrated.
D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000139:chemically induced* / Q000150:complications / Q000628:therapy; D001379:Azathioprine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008105:Liver Cirrhosis, Biliary / Q000150:complications* / Q000628:therapy; D010396:Penicillamine / Q000009:adverse effects*; D010956:Plasmapheresis
D010396:Penicillamine; D001379:Azathioprine