Quantitative histochemical changes in intervertebral discs in diabetes.
A comparison of the nuclei pulposi of 4 diabetic and 2 nondiabetic subjects disclosed a statistically significant decrease in hexosamine, a statistically significant increase of hydroxyproline, and significantly increased activities of four enzymes involved in the metabolism of carbohydrates. The results are considered preliminary in view of the small size of the sample.
D000328:Adult; D000368:Aged; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000378:metabolism / Q000473:pathology*; D005260:Female; D006801:Humans; D007403:Intervertebral Disc / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013122:Spinal Diseases / Q000209:etiology* / Q000473:pathology; D013167:Spondylitis, Ankylosing / Q000209:etiology