title: The Icr:Ha(ICR) mouse: a current account of breeding, mutations, diseases and mortality.
abstract: This stock of albino mice is minimally inbred (0.5% per generation), and has been rigidly selected for fecundity. It is widely employed in oncological and pharmaceutical research. Spontaneous tumours arose in 55% of animals, multiple in 28%, averaging 1.66 per mouse. Females developed tumours at an earlier age than males. Predominant tumour types were pulmonary (23.1%), lymphoreticular (20%), and mammary (14%--23% of females). Miscellaneous tumour types (42.9%) ranged in frequency from 0.2 to 2.0%, the latter being hepatomas. Distribution of mammary tumours indicated that milk-borne mammary tumour virus was absent. Non-neoplastic disease was present in 58.6%, 24.1% being pulmonary and predominant in the young, while renal (31.2%) and cardiovascular (10.2%) disease was common in the elderly. Males outlived females.
mesh_terms: D000375:Aging; D000745:Anemia, Hemolytic, Congenital / Q000662:veterinary; D000818:Animals; D001947:Breeding; D002318:Cardiovascular Diseases / Q000662:veterinary; D012734:Disorders of Sex Development / Q000662:veterinary; D005260:Female; D007674:Kidney Diseases / Q000662:veterinary; D008171:Lung Diseases / Q000662:veterinary; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009026:Mortality; D009154:Mutation; D009374:Neoplasms, Experimental / Q000453:epidemiology*; D012737:Sex Factors