Synthesis of gamma-carboxyglutamic acid and its derivatives via Mannich-base condensation.
This report describes the synthesis of N alpha-formyl and N alpha-benzyloxycarbonyl-gamma, gamma-di-t-butyl-gamma-carboxyglutamic acid via Mannich-base condensation starting from di-t-butyl malonate and diethylformamido or benzyloxycarbonylamidomalonate.
D015055:1-Carboxyglutamic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis*; D000478:Alkylation; D055598:Chemical Phenomena; D002621:Chemistry; D005971:Glutamates / Q000138:chemical synthesis*; D008352:Mannich Bases
D005971:Glutamates; D008352:Mannich Bases; D015055:1-Carboxyglutamic Acid