title: Selective afterload reduction in the treatment of septal rupture complicating myocardial infarction. A case report.
abstract: Interventricular septal rupture complicating acute myocardial infarction is usually fatal unless corrective surgery can be delayed until adequate healing of the septum has occurred. A case is reported in which the degree of shunting through the ventricular septal defect was reduced by the use of hydralazine, a drug which selectively reduces peripheral vascular resistance. In spite of the fact that this patient eventually died before surgical repair could be carried out, the hydralazine did bring about a significant improvement in the left-to-right shunt ratio.
mesh_terms: D005260:Female; D006345:Heart Septal Defects, Ventricular / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D006830:Hydralazine / Q000494:pharmacology / Q000627:therapeutic use*; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications*; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D006830:Hydralazine