Survival of mice receiving melanoma transplants is promoted by hydroquinone.
In BALB/c female mice with melanoma transplants, the incidence of "takes" is decreased and survival is increased by hydroquinone, a melanocytolytic agent. The mechanism of drug action is suggested by via DNA. The significant and high degree of positive response to hydroquinone treatment in vivo is encouraging for the clinical management of melanoma with melanocytolytic agents.
D000818:Animals; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D005260:Female; D006873:Hydroquinones / Q000378:metabolism / Q000627:therapeutic use*; D008544:Melanocytes / Q000378:metabolism; D008545:Melanoma / Q000188:drug therapy*; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy
D006873:Hydroquinones