Regional cerebral blood flow in the rat as determined by particle distribution and by diffusible tracer.
Measurements of total and regional cerebral blood flow in paralyzed rats maintained on 70% N2O/30% O2 obtained by a diffusible tracer technique, iodoantipyrine, and by a particle distribution method, microspheres, have been compared. Total CBF values were in good agreement, 0.86 +/- 0.07 ml/g/min (PaCO2 37.3 +/- 1.5, iodoantipyrine method) and 0.88 +/- 0.02 (PaCO2 36.2 +/- 0.8, microsphere method). Regional cerebral blood flows showed good agreement with the 2 methods, with highest flow in the colliculi, striatum and cerebral cortex and lowest flows in the hypothalamus, pons medulla and cerebellum. The iodoantipyrine method is technically easier to perform and had a higher precision.
D000818:Animals; D000983:Antipyrine / Q000008:administration & dosage / Q000031:analogs & derivatives; D001921:Brain / Q000000981:diagnostic imaging / Q000601:surgery; D002250:Carbon Radioisotopes / Q000008:administration & dosage*; D002560:Cerebrovascular Circulation; D002565:Cerium Radioisotopes / Q000008:administration & dosage*; D008297:Male; D008863:Microspheres; D009609:Nitrous Oxide; D011877:Radionuclide Imaging; D051381:Rats
D002250:Carbon Radioisotopes; D002565:Cerium Radioisotopes; D009609:Nitrous Oxide; D000983:Antipyrine; C008135:iodoantipyrine