Delay in onset of heat-sensitivity in a methylcholanthrene-induced tumor.
A delay in onset of heat-sensitivity was demonstrated for methylcholanthrene-induced tumors implanted in the footpad of BALB/cJ or CAF1/J female mice. A heat dose of 46.0 +/- 0.1 degrees C/10 min resulted in long-term cure for a majority of the mice heated on day 7 post-implantation but cured only 4% of those heated on day zero and non-heated on day 1 post-implantation. By comparison, all untreated controls grew tumors which never spontaneously regressed and were dead within 3 months post-implantation.
D000818:Animals; D005260:Female; D006358:Hot Temperature; D008748:Methylcholanthrene; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000139:chemically induced* / Q000628:therapy; D013997:Time Factors; D014184:Transplantation, Homologous
D008748:Methylcholanthrene