A novel effect of cobalt treatment on calcium-dependent responses of the cockroach salivary gland.
After incubation in calcium-free solutions containing cobalt, the readmission of calcium caused prolonged but reversible hyperpolarization of acinar cells of cockroach salivary glands and prolonged fluid secretion. It is suggested that cobalt treatment increases the permeability of the acinar cell membrane to calcium.
D000818:Animals; D002118:Calcium / Q000502:physiology*; D002463:Cell Membrane Permeability / Q000187:drug effects; D003035:Cobalt / Q000494:pharmacology*; D003058:Cockroaches; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D012469:Salivary Glands / Q000187:drug effects* / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects
D003035:Cobalt; D002118:Calcium