Response of pathological ischaemic muscle pain to analgesics.
1 Twenty-four patients suffering from severe pain due to chronic occlusive arterial disease of the legs were given oral doses of indoprofen (200 mg), ibuprofen (300 mg) and placebo. 2 Differences in pain intensity scored on a five-point scale were taken as measurement of pain relief. 3 This double-blind, cross-over trial showed that indoprofen had significantly greater analgesic effect than placebo and reference drug. 4 From a methodological point of view there are many arguments on favour of pathological ischaemic pain as a test for clinical assessment of analgesics.
D000368:Aged; D000700:Analgesics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use; D007216:Indoprofen / Q000627:therapeutic use; D007511:Ischemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000098:blood supply; D009135:Muscular Diseases / Q000188:drug therapy* / Q000209:etiology; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D012039:Regional Blood Flow; D013997:Time Factors
D000700:Analgesics; D007216:Indoprofen; D007052:Ibuprofen