title: Active site structural change of alpha-chymotrypsin due to 2-halogeno-ethanols; comparison with ethanol, I-propanol, and urea.
abstract: 2-Halogeno-ethanols change the active site structure of alpha-chymotrypsin more rapidly and effectively than ethanol, 1-propanol and urea, probably before producing an extensive conformation change.
mesh_terms: D000433:1-Propanol / Q000494:pharmacology*; D001665:Binding Sites; D002918:Chymotrypsin / Q000378:metabolism*; D000431:Ethanol / Q000031:analogs & derivatives / Q000494:pharmacology*; D005023:Ethylene Chlorohydrin / Q000494:pharmacology; D007700:Kinetics; D013329:Structure-Activity Relationship; D014270:Trifluoroethanol / Q000494:pharmacology; D014508:Urea / Q000494:pharmacology*
chemical_list: D000431:Ethanol; D014270:Trifluoroethanol; D005023:Ethylene Chlorohydrin; D014508:Urea; D000433:1-Propanol; D002918:Chymotrypsin; C025475:ethylene bromohydrin