Osteoclasts derived from haematopoietic stem cells.
The origins of the multinucleated osteoclast have been controversial, with osteogenic precursors and haematopoietic stem cells as candidates. Recent evidence for the latter is persuasive but circumstantial. We report here direct evidence obtained in radiation chimaeras from a natural cytoplasmic cell marker transmitted by the donated haematopoietic stem cell.
D000818:Animals; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D006412:Hematopoietic Stem Cells / Q000166:cytology*; D008247:Lysosomes / Q000648:ultrastructure; D051379:Mice; D010010:Osteoclasts / Q000166:cytology* / Q000648:ultrastructure; D011828:Radiation Chimera