[Effect of pyridoxal phosphate and pantothenate derivatives on gamma-aminobutyric shunt in the brain of mice].
Repeated administration of D-pantothenate Ca, D-homopantothenate Ca and pantethine at a dose of 150 mmole/kg of body weight (9 injections within 3 days) led to alterations in activity of GABA-shunt enzymes as well as in content of free amino acids in mouse brain. These alterations suggest that B3-vitamin preparations potentiate the regulating effect on gamma-aminobutyrate pathway, which shunts the alpha-ketoglutarate dehydrogenase reaction, depending on CoA content. The most distinct but short-term intesification of the GABA-shung was observed in treatment with homopantothenate containing GABA molecule. Pantothenate and pantethine caused similar alterations, consisting in activation of GABA production and in inhibition of its utilization; in this case pantethine was less effective. Pyridoxal phosphate activated GABA-shunt; this resulted in accelerated decrease in content of dicarboxylic amino acids and their amides.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D004789:Enzyme Activation / Q000187:drug effects; D005609:Free Radicals; D005971:Glutamates / Q000378:metabolism; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010204:Pantetheine / Q000031:analogs & derivatives / Q000494:pharmacology; D010205:Pantothenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D011732:Pyridoxal Phosphate / Q000494:pharmacology*; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005609:Free Radicals; D005971:Glutamates; D010205:Pantothenic Acid; D010204:Pantetheine; D005680:gamma-Aminobutyric Acid; D011732:Pyridoxal Phosphate
Vliianie piridoksal'fosfata i proizvodnykh pantotenata na gamma-aminobutiratnyĭ shunt v golovnom mozge mysheĭ.