title: Delayed neurotoxicity caused by chronic feeding of organophosphates requires a high-point of inhibition of neurotoxic esterase.
abstract: Experiments are reported showing that chronic feeding of either mono-2-cresyl diphenyl phosphate or diisopropyl phosphorofluoridate (DFP) to hens does not cause clinically observable delayed neurotic effects prior to a point when inhibition of neurotoxic esterase (NTE) of brain and spinal cord reaches 70-90%. These results are contrary to another study with diisopropyl phosphorofluoridate, which claims neuropathy without high inhibition, but are supported by results of chronic feeding experiments with tri-o-cresyl phosphate. The discrepancy cannot be attributed to differences in the strains of hens used.
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000187:drug effects* / Q000201:enzymology; D002645:Chickens; D004950:Esterases / Q000037:antagonists & inhibitors*; D007531:Isoflurophate / Q000633:toxicity; D009943:Organophosphorus Compounds / Q000633:toxicity*; D013997:Time Factors
chemical_list: D009943:Organophosphorus Compounds; D007531:Isoflurophate; D004950:Esterases