Antidiuretic and thermogenic effects of intracerebroventricular prostaglandin H2 in ethanol-anaesthetized rats.
When PGH2 was administered intracerebroventricularly at doses of 5 and 15 nmoles in ethanol-anaesthetized rats, alcohol diuresis was inhibited and rectal temperature, blood pressure and heart rate were all significantly increased.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects*; D004231:Diuresis / Q000187:drug effects*; D000431:Ethanol / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D007276:Injections, Intraventricular; D011449:Prostaglandin Endoperoxides / Q000494:pharmacology*; D011463:Prostaglandins H / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats
D011449:Prostaglandin Endoperoxides; D011463:Prostaglandins H; D000431:Ethanol