Mammary tumorigenic effect of a new nitrosourea, 1,3-dibutyl-l-nitrosourea (B-BNU), in female Donryu rats.
Four groups (groups 1-4) of female Donryu rats were given continuously 400, 200, 100, or 0 ppm solution of 1,3-dibutyl-l-nitrosourea (B-BNU) as their drinking water, and were studied for the development of tumors. The incidence of mammary tumors was 15/19 (79%), 20/24 (83%), 21/26 (81%), and 8/25 (32%) in groups 1, 2, 3, and 4, respectively. In addition, hematopoietic neoplasms, uterine tumors, and vaginal tumors developed in 13, 11, and six rats, respectively in 69 treated rats. Other tumors were infrequent.
D000818:Animals; D002273:Carcinogens; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000633:toxicity*; D051381:Rats; D014594:Uterine Neoplasms / Q000139:chemically induced; D014625:Vaginal Neoplasms / Q000139:chemically induced
D002273:Carcinogens; D009607:Nitrosourea Compounds; C023397:1,3-dibutyl-1-nitrosourea