Splanchnic somatostatin: a hormonal regulator of nutrient homeostasis.
Free (approximately 1600 daltons) somatostatin-like immunoreactivity was identified in arterial plasma of dogs that had received a test meal. Neutralization of circulating somatostatin while the dogs were consuming a fatty meal increased the plasma concentrations of triglycerides, gastrin, pancreatic polypeptide, and insulin after the meal. It is concluded that, in the dog, somatostatin is a true hormone that regulates the movement of nutrients from the gut to the internal environment.
D000818:Animals; D004285:Dogs; D004435:Eating; D005755:Gastrins / Q000097:blood; D013006:Growth Hormone / Q000097:blood*; D006706:Homeostasis; D006863:Hydrogen-Ion Concentration; D007328:Insulin / Q000097:blood; D010191:Pancreatic Polypeptide / Q000097:blood; D013004:Somatostatin / Q000097:blood / Q000502:physiology*; D014280:Triglycerides / Q000097:blood*
D005755:Gastrins; D007328:Insulin; D014280:Triglycerides; D013004:Somatostatin; D010191:Pancreatic Polypeptide; D013006:Growth Hormone