Influence of hypo- and hyperthyroidism on noradrenaline metabolism in brown adipose tissue of the developing rat.
We studied the noradrenaline content, and monoamine oxidase (MAO) and catechol-O-methyltransferase (COMT) activities in brown adipose tissue (BAT) of normal, hypothyroid, and hyperthyroid developing rat. In the newborn, thyroid hormones are necessary for the increase in noradrenaline content which occurs between 0 and 5 days. Hypothyroidism increases both MAO and COMT activities. Hyperthyroidism decreases MAO activity but not noradrenaline content or COMT activity. In the full-term fetus, hypothyroidism decreases noradrenaline content as in the newborn, and also decreases MAO and COMT activities. It is suggested that thyroid hormones could modulate BAT nonshivering thermogenesis by regulating the level of noradrenaline, the direct mediator of heat production.
D002001:Adipose Tissue, Brown / Q000254:growth & development / Q000378:metabolism*; D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002394:Catechol O-Methyltransferase / Q000378:metabolism*; D005260:Female; D006980:Hyperthyroidism / Q000139:chemically induced / Q000378:metabolism*; D007037:Hypothyroidism / Q000139:chemically induced / Q000378:metabolism*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism*; D011247:Pregnancy; D011441:Propylthiouracil; D051381:Rats; D013974:Thyroxine
D011441:Propylthiouracil; D008995:Monoamine Oxidase; D002394:Catechol O-Methyltransferase; D013974:Thyroxine; D009638:Norepinephrine