title: Inhibition by idrocilamide of the disposition of caffeine.
abstract: The pharmacokinetics of caffeine are greatly altered by concomitant administration of idrocilamide. In four healthy volunteers id rocilamide inhibited the biotransformation of caffeine and increased its half-life nine times. The untoward neuropsychiatric effects of idrocilamide are the consequence of abnormal accumulation of caffeine in regular consumers of caffeine-containing foods and beverages.
mesh_terms: D000328:Adult; D001711:Biotransformation; D002110:Caffeine / Q000378:metabolism*; D004347:Drug Interactions; D004983:Ethanolamines / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008954:Models, Biological; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D013997:Time Factors; D014970:Xanthines / Q000652:urine
chemical_list: D004983:Ethanolamines; D009125:Muscle Relaxants, Central; D014970:Xanthines; D002110:Caffeine; C004560:idrocilamide