A new method for experimental study on gastric mucosal damage--changes in gastric mucosa of rat in hypoxemia.
We have demonstrated development of mucosal damage in rats maintained in a hypoxic condition. The gastric lesions were observed only in the corpus ventriculi in almost all cases, and they were rated as Ul-1 erosions histopathologically. The method has proven to facilitate the induction of long-sustained, stable hypoxemia of any desired degree in animals and is concluded to be appropriate for an experimental model of ulceration designed for the study of defensive mechanisms.
D000818:Animals; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000473:pathology*; D000860:Hypoxia / Q000150:complications / Q000473:pathology*; D008297:Male; D010437:Peptic Ulcer / Q000209:etiology / Q000473:pathology*; D051381:Rats