[Fluorothane pharmaco kinetics in brain structures and the permeability of the hemato-encephalic barrier in postnatal ontogeny].
Distribution of ftorotan in the brain structures (hemispheres, thalamus, cerebellum, limbic structures) and blood, and permeability of the blood brain barrier of the listed brain structures were studied by gas chromatography in postnatal ontogenesis (7, 17, 30, 60 and 90 days) of white rats during three stages of anesthesia -- initial, "surgical" and final ones. It has been established that the histohematic barrier is most permeable prior to 17-day age; the blood brain barrier is the least permeable in 7- and 17-day-old animals. Sorption of the brain tissue increases after 17 days and reaches maximum by day 90 of the postnatal development.
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects*; D006221:Halothane / Q000378:metabolism*; D007700:Kinetics; D051381:Rats; D013997:Time Factors; D014018:Tissue Distribution
D006221:Halothane
Farmakokinetika ftorotana v strukturakh mozga i pronitsaemost' gematoéntsefalicheskogo bar'era v postnatal'nom ontogeneze.