Bis-trimethylsilylcefamandole: an unusually stable trimethylsilyl-intermediate.
The preparation of crystalline bis-trimethylsilylcefamandole (7) and its utility in the preparation and purification of cefamandole are described. Although stable to solvolysis in isopropyl alcohol, 7 underwent smooth conversion to cefamandole in the presence of water, methanol, or ethanol.
D000215:Acylation; D002435:Cefamandole / Q000031:analogs & derivatives / Q000138:chemical synthesis; D055598:Chemical Phenomena; D002621:Chemistry; D003460:Crystallization; D004355:Drug Stability; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy
D002435:Cefamandole; C024644:bis(trimethylsilyl)cefamandole