Multiple acquired haemostatic defects. Case report and review of the literature.
A 14-year-old girl presented with severe haemorrhagic diathesis. Her past history suggested a congenital bleeding disorder. Investigations disclosed severe deficiency of all four vitamin K-dependent factors and a functional defect of platelets. These were caused by simultaneous administration of vitamin K antagonists and anti-inflammatory drugs. A complete clinical and laboratory recovery took place following withdrawal of drugs. The severity of the haemorrhagic diathesis prompted us to describe the case in order to draw the attention of medical personnel to the dangerous potentiation effects of different drugs administered with vitamin K antagonists.
D000293:Adolescent; D001777:Blood Coagulation; D003374:Coumarins / Q000009:adverse effects; D003937:Diagnosis, Differential; D005260:Female; D006474:Hemorrhagic Disorders / Q000139:chemically induced / Q000175:diagnosis*; D006487:Hemostasis; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time; D013924:Thrombophlebitis / Q000188:drug therapy; D010837:Vitamin K 1 / Q000008:administration & dosage
D003374:Coumarins; D010837:Vitamin K 1; D007213:Indomethacin