Presence of asbestos bodies in organs other than the lung.
This study was designed to test the hypothesis that subjects with many asbestos bodies in their lungs at autopsy would also have asbestos bodies in various other organs. The subjects included 19 cases with diagnosis of asbestosis at death (two of these had mesothelioma, five had lung cancer) and 18 with pleural plaques but not asbestosis. Occupational histories were obtained from relatives. In subjects occupationally exposed to asbestos, large numbers of asbestos bodies were found in the lungs, and in most of these, asbestos bodies were found in many of the other organs examined. In the 18 cases with only pleural plaques found at autopsy, considerably fewer asbestos bodies were found in the lungs. The number of other organs with one or more asbestos bodies ranged from 32 percent to 62 percent of the sites examined. The findings seem to confirm the hypothesis of the study.
D000368:Aged; D001194:Asbestos / Q000378:metabolism*; D001195:Asbestosis / Q000378:metabolism; D004781:Environmental Exposure; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008168:Lung / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D009790:Occupations; D010179:Pancreas / Q000378:metabolism; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D001194:Asbestos