Preparation and biological actions of N-2,2,2-trifluoroethyl-2-(3,4-dihydroxyphenyl)ethylamine.
N-2,2,2,-Trifluoroethyl-2-(3,4-dihydroxyphenyl)ethylamine was synthesized and compared to N-ethyl-2-(3,4-dihydroxyphenyl)-ethylamine and dopamine for activity on adenylate cyclase in the rat striatum. Both dopamine and N-ethyl-2-(3,4-dihydroxyphenyl)ethylamine stimulated adenylate cyclase activity in a dose-dependent fashion. The N-trifluoroethyldopamine analog at 1 x 10(-4) M induced a weak effect. The compounds were evaluated further by studying their relaxant effects in isolated rabbit renal and ear arteries. Both the N-ethyl- and N-trifluoroethyldopamine analogs produced a relaxant effect but demonstrated no selectivity for dopamine receptors.
D000067956:Adenylyl Cyclase Inhibitors; D000818:Animals; D002421:Caudate Nucleus / Q000201:enzymology; D004298:Dopamine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects; D011699:Putamen / Q000201:enzymology; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*
D000067956:Adenylyl Cyclase Inhibitors; D011954:Receptors, Dopamine; C023655:N-2,2,2-trifluoroethyl-2-(3,4-dihydroxyphenyl)ethylamine; D004298:Dopamine