A note on the transformation of the dbrB carcionoma.
A heterofore strain-specific mammary carcinoma of the mouse was found to have acquired altered characteristics. The dbrB transplantable tumor originated in a DBA mouse as a spontaneous carcinoma in 1918. It was not until recently, when this tumor was transferred from mice to storage in the frozen state, that a marked transformation occurred both in vivo and in vitro. Certain morphologic differences were also noted.
D000818:Animals; D001201:Ascites / Q000473:pathology; D002277:Carcinoma / Q000473:pathology*; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002478:Cells, Cultured; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D013696:Temperature