[Effect of nonachlazine on ATP, ADP, and lactic acid concentration in intact and ischemic myocardium].
It has been shown that nonachlazin in a dose of 6 mg/kg injected intravenously to cats 15 minutes after occlusion of the left descending coronary artery produced a 42% decrease in the content of lactic acid in the left heart ventricle as compared to its content in ischemic myocardium. Nonachlazin brought to normal the content of ATP that had been decreased under acute myocardial ischemia. Concurrent recording of ECG readings showed them to be improved. The parameters studied did not change in the animals with intact myocardium after the drug administration. It is suggested that the favourable clinical effect seen is accounted for by nonachlazin-activated glycolysis and oxidative mitochondrial phosphorylation in the myocardium.
D000244:Adenosine Diphosphate / Q000032:analysis*; D000255:Adenosine Triphosphate / Q000032:analysis*; D000818:Animals; D002415:Cats; D003327:Coronary Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000378:metabolism; D004562:Electrocardiography; D007773:Lactates / Q000032:analysis*; D009206:Myocardium / Q000032:analysis*; D009628:Nonachlazine / Q000627:therapeutic use*; D010640:Phenothiazines / Q000627:therapeutic use*
D007773:Lactates; D010640:Phenothiazines; D000244:Adenosine Diphosphate; D009628:Nonachlazine; D000255:Adenosine Triphosphate
Vliianie nonakhlazina na soderzhanie ATF, ADF, molochnoĭ kisloty v intaktnom i ishemizirovannom miokarde.