Familial retinoblastoma: segregation of chromosome 13 in four families.
Fluorescent markers on chromosome 13 have been used to study familial retinoblastoma. One family showed concordant segregation of a particular chromosome 13 and retinoblastoma from the affected parent to the affected children. In three other families, segregation was discordant. Meiotic crossing over with recombination is proposed as the explanation.
D000328:Adult; D002648:Child; D002675:Child, Preschool; D002871:Chromosome Banding; D002901:Chromosomes, Human, 13-15; D003434:Crossing Over, Genetic; D005134:Eye Neoplasms / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008214:Lymphocytes; D008297:Male; D008856:Microscopy, Fluorescence; D008957:Models, Genetic; D010375:Pedigree; D012175:Retinoblastoma / Q000235:genetics*