Investigations on riboflavin penetration across erythrocyte cell membrane in healthy subjects and patients with chronic renal failure.
The reported investigations showed that riboflavin in a concentration of 5.0 X 10(-5)M penetrates across erythrocyte membrane and that the intensity of this process depends on the incubation time. ATP added to the incubation medium to a concentration of 10(-6)M or glucose in a 10(-3)M concentration enhanced riboflavin transport across the membrane. In experiments with erythrocytes obtained from patients with chronic renal failure riboflavin penetration into the erythrocytes was inhibited.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D000293:Adolescent; D000328:Adult; D001692:Biological Transport; D002463:Cell Membrane Permeability / Q000187:drug effects; D002478:Cells, Cultured; D003470:Culture Media; D004910:Erythrocyte Membrane / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000378:metabolism; D012256:Riboflavin / Q000097:blood*; D013268:Stimulation, Chemical
D003470:Culture Media; D000255:Adenosine Triphosphate; D005947:Glucose; D012256:Riboflavin