Radioprotective action of haematoporphyrin on X-irradiated in trypsin.
Dose-response curves were obtained for trypsin X-irradiated in aqueous solution (4.6 x 10(-6)M), alone or after incubation with haematoporphyrin (Hp). When trypsin was irradiated alone (exposure doses ranging from 10 to 25 kR) the exponential dose-response curve showed a D37 equal to 17200 R. When trypsin was incubated with Hp before irradiation a D37 equal to 61900 R was obtained, with a dose reduction factor of 3.6. Therefore in our experimental conditions Hp shows a highly significant radioprotective action.
D004307:Dose-Response Relationship, Radiation; D006415:Hematoporphyrins / Q000494:pharmacology; D011837:Radiation-Protective Agents; D013053:Spectrophotometry; D014357:Trypsin / Q000378:metabolism / Q000528:radiation effects*
D006415:Hematoporphyrins; D011837:Radiation-Protective Agents; D014357:Trypsin