Identification of staphylococcal Panton-Valentine leukocidin as a potent dermonecrotic toxin.
The Panton-Valentine leukocidin of Staphylococcus aureus was shown to exhibit a potent dermonecrotic effect when injected intradermally into rabbits. This effect could be abrogated by immunizing animals with the F component or both components, but immunization with the S component appeared to exacerbate certain of the intradermal responses.
D000818:Animals; D007106:Immune Sera; D007114:Immunization; D007428:Intradermal Tests; D007956:Leukocidins / Q000494:pharmacology*; D009336:Necrosis; D011817:Rabbits; D012867:Skin / Q000473:pathology; D013211:Staphylococcus aureus / Q000276:immunology*; D014118:Toxins, Biological / Q000276:immunology* / Q000494:pharmacology
D007106:Immune Sera; D007956:Leukocidins; D014118:Toxins, Biological