title: Quantitative analysis of oxepinac in human plasma, urine and saliva by gas chromatography--mass fragmentography.
abstract: A sensitive and specific method is described for the quantitative analysis of 6,11-dihydro-11-oxo-dibenz[b,e]oxepin-3-acetic acid (oxepinac) in human plasma, urine and saliva. Oxepinac and internal standard are extracted from acidified plasma, urine or saliva, converted to the corresponding n-propyl esters and analysed by gas chromatography--mass fragmentography using selected ion monitoring. The method is accurate and precise over the range 100 microgram/ml to 1.0 ng/ml. The method has been applied to the analysis of plasma, urine and saliva from healthy volunteers receiving therapeutic doses of oxepinac.
mesh_terms: D000085:Acetates / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use / Q000652:urine; D000893:Anti-Inflammatory Agents / Q000032:analysis; D003990:Dibenzoxepins / Q000032:analysis* / Q000097:blood / Q000627:therapeutic use / Q000652:urine; D004305:Dose-Response Relationship, Drug; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D012463:Saliva / Q000032:analysis*; D013696:Temperature
chemical_list: D000085:Acetates; D000893:Anti-Inflammatory Agents; D003990:Dibenzoxepins; C025060:DD-3305; C025032:oxepinac