title: Liposomes in immunology: multilamellar phosphatidylcholine liposomes as a simple, biodegradable and harmless adjuvant without any immunogenic activity of its own.
abstract: Multilamellar phosphatidylcholine liposomes were coated with the antigens human serum  albumin (HSA) or bovine gamma globulin (BGG) simply by suspending the liposomes in a solution of the antigens. Antigen coated  phosphatidylcholine liposomes showed nearly the same adjuvant activity after intravenous injection as liposomes of a more complex phospholipid composition. Since phosphatidylcholine liposomes are biodegradable, harmless, easily obtainable, have no immunogenic activity of their own and may be administered intravenously, they seem to be a promising immunoadjuvant.
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000941:Antigens; D001673:Biodegradation, Environmental; D002784:Cholesterol / Q000494:pharmacology; D006801:Humans; D008081:Liposomes / Q000276:immunology*; D008297:Male; D010712:Phosphatidic Acids / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology; D011817:Rabbits; D012709:Serum Albumin / Q000276:immunology; D013109:Sphingomyelins / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D000941:Antigens; D008081:Liposomes; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D012709:Serum Albumin; D013109:Sphingomyelins; D002784:Cholesterol