title: Thermal decomposition of ibuproxam.
abstract: The thermal behavior of ibuproxam was studied at several temperatures, and the degradation products were separated by column chromatography and ethereal extractions. The resulting products were ibuprofen [2-(4-isobutylphenyl)propionic acid], 1-(4-isobutylphenyl)-ethylamine, 4-isobutylacetophenone, and 4-isobutylacetophenone oxime. The compounds were identified by IR, UV, and NMR spectroscopy and elemental analyses. 4-Isobutylacetophenone was treated with hydroxylamine to give 4-isobutylacetophenone oxime.
mesh_terms: D000893:Anti-Inflammatory Agents; D044482:Benzeneacetamides; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D006358:Hot Temperature; D006877:Hydroxamic Acids
chemical_list: D000893:Anti-Inflammatory Agents; D044482:Benzeneacetamides; D006877:Hydroxamic Acids; C025377:ibuproxam