title: Experiments with radiopaque perfluorocarbon emulsions for selective opacification of organs and total body angiography.
abstract: Emulsions of radiopaque perfluorocarbon with small particle size were prepared by sonication and concentrated by centrifugation. The emulsions were well tolerated when given intravenously to rats in a dose up to 20 ml/kg. Whole-body angiograms were obtained for up to 6 hours after injection with visualization of vessels smaller then 1 mm. Hepatosplenograms were obtained after 2 hours and for several days after injections of radiopaque perfluorocarbon. Contrast enhancement was also seen in the myocardium, ovaries, adrenal glands, and intestines with brominated perfluorocarbon emulsions.
mesh_terms: D000792:Angiography; D000818:Animals; D003287:Contrast Media / Q000008:administration & dosage; D005260:Female; D005466:Fluorocarbons / Q000008:administration & dosage; D010316:Particle Size; D011856:Radiographic Image Enhancement; D011859:Radiography; D051381:Rats; D014018:Tissue Distribution
chemical_list: D003287:Contrast Media; D005466:Fluorocarbons