Anorexigenic effects of two amines obtained from Catha edulis Forsk. (Khat) in rats.
The anorexigenic effects of cathine (phenylpropanolamine) and cathinone (alpha-aminopropiophenone), both amines obtained from Catha edulis Forsk. (Khat) were investigated by acute and chronic experiments in rats. Amphetamine was included for comparison purposes. Both khat amines reduced food intake when administered acutely and body weight when given chronically. Cathinone was more effective than cathine, and both were less active than amphetamine. Partial or total cross-tolerance was observed among the 3 drugs.
D000470:Alkaloids / Q000494:pharmacology*; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001067:Appetite Depressants; D001835:Body Weight / Q000187:drug effects; D004361:Drug Tolerance; D004435:Eating / Q000187:drug effects; D010665:Phenylpropanolamine / Q000494:pharmacology*; D010946:Plants, Medicinal; D011427:Propiophenones / Q000494:pharmacology*; D051381:Rats
D000470:Alkaloids; D001067:Appetite Depressants; D011427:Propiophenones; C005331:norpseudoephedrine; D010665:Phenylpropanolamine; C023665:cathinone; D000661:Amphetamine