Intrarenal growth of the Walker 256 tumour and renal vein concentrations of PGE2, PGF 2 alpha, and TXB2: effects of diazepam.
Walker 256 tumours grafted under the left kidney capsules in rats showed enhanced growth following daily treatment with diazepam 500 micrograms (1.7 mg/kg body weight) subcutaneously but not with 1250 micrograms. Thromboxane B2 (the metabolite of TXA2) levels in venous drainage from both the tumour bearing left kidney and from the right control kidney were reduced significantly in all the three groups of tumour bearing rats. Plasma PGE2 was higher in the venous drainage from the tumour bearing left kidney than from the right control kidney. Significantly higher levels were measured following 500 micrograms but not after 1250 micrograms of diazepam. Plasma PGF2 alpha on the other hand, was lower in the plasma from the tumour bearing kidney and was further lowered in animals receiving diazepam treatment.
D000818:Animals; D002279:Carcinoma 256, Walker / Q000097:blood*; D003975:Diazepam / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008297:Male; D011458:Prostaglandins E / Q000097:blood*; D011460:Prostaglandins F / Q000097:blood*; D051381:Rats; D012082:Renal Veins; D013929:Thromboxane B2 / Q000097:blood*; D013931:Thromboxanes / Q000097:blood*
D011458:Prostaglandins E; D011460:Prostaglandins F; D013931:Thromboxanes; D013929:Thromboxane B2; D003975:Diazepam