Inhibition of lordotic behavior in female rats following intracerebral infusion of anticholinergic agents.
Cholinergic antagonists were bilaterally infused into forebrain areas of ovariectomized female rats brought into sexual receptivity by administration of estrogen and progesterone. Infusion of hemicholinium-3 (HG-3, 5 or 7.5 micrograms/cannula), an acetylcholine synthesis inhibitor believed to interfere with choline uptake, decreased the incidence of lordotic behavior displayed by females. This inhibition was prevented by infusion of choline chloride (120 micrograms/cannula) along with HC-3. Atropine sulfate, an acetylcholine receptor blocker, also reduced lordotic behavior in females following intracerebral infusion (20 micrograms/cannula). These results lend support to the suggestion that lordotic behavior is facilitated by central cholinergic activity.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002369:Castration; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006426:Hemicholinium 3 / Q000494:pharmacology; D007276:Injections, Intraventricular; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013997:Time Factors
D004967:Estrogens; D010276:Parasympatholytics; D006426:Hemicholinium 3; D011374:Progesterone; D001285:Atropine