Antitumor agents from bohemic acid complex, III. The isolation of marcellomycin, musettamycin, rudolphomycin, mimimycin, collinemycin, alcindoromycin, and bohemamine.
Six anthracycline antitumor agents, marcellomycin, musettamycin, rudolphomycin, alcindoromycin, collinemycin, and mimimycin, have now been isolated from bohemic acid complex. This has been achieved by classical column chromatography with Sephadex LH-20 and ammonia-neutralized silica and by analytical and prepatative hplc techniques with normal phase systems containing aqueous ammonia.
D000818:Animals; D018943:Anthracyclines; D000900:Anti-Bacterial Agents / Q000032:analysis*; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005260:Female; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D008545:Melanoma / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D009279:Naphthacenes / Q000032:analysis* / Q000302:isolation & purification* / Q000494:pharmacology; D009374:Neoplasms, Experimental / Q000188:drug therapy; D011763:Pyrrolizidine Alkaloids / Q000302:isolation & purification / Q000494:pharmacology
D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; D011763:Pyrrolizidine Alkaloids; C015338:marcellomycin; C015374:musettamycin; C015039:bohemic acid complex; C021739:rudolfomycin; C025546:alcindoromycin; C025545:collinemycin; C025548:bohemamine