Chronic manganese oxide administration to preweanling rats: manganese accumulation and distribution.
Mn accumulation was evaluated in selected tissues of preweanling rats dosed daily with particulate Mn3O4. Significant findings include a high rate of Mn accumulation in the preweanling rat; a Mn dose-related acceleration of postpartum liver iron depletion; a Mn dose-related depression in red blood cells, hematocrit, hemoglobin, body weight, and survival by 21 d postpartum; and a Mn distribution in tissues with liver greater than brain greater than or equal to kidney greater than testes at 18-21 d of age.
D000375:Aging; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007501:Iron / Q000378:metabolism; D007928:Lethal Dose 50; D008345:Manganese / Q000097:blood / Q000378:metabolism; D020149:Manganese Poisoning; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D014018:Tissue Distribution
D008345:Manganese; D007501:Iron