Kainic acid neurotoxiocity in granuloprival cerebellar cultures.
Granuloprival cerebellar cultures devoid of cortical presynaptic glutamatergic fibers were exposed to nutrient medium incorporating either 10(-3) M D-glutamic acid or 10(-4) M kainic acid. No changes were evident in cultures exposed to the former, while cortical neurons were destroyed in kainate-treated explants. These results suggest that kainic acid neurotoxic effects can be manifested in the absence of glutamatergic afferent fibers.
D000344:Afferent Pathways / Q000187:drug effects; D000818:Animals; D001369:Axons / Q000187:drug effects; D002525:Cerebellar Cortex / Q000187:drug effects*; D046508:Culture Techniques; D003561:Cytarabine / Q000494:pharmacology; D005971:Glutamates / Q000378:metabolism / Q000494:pharmacology; D007608:Kainic Acid / Q000633:toxicity*; D051379:Mice; D009474:Neurons / Q000187:drug effects; D011689:Purkinje Cells / Q000187:drug effects; D011759:Pyrrolidines / Q000633:toxicity*
D005971:Glutamates; D011759:Pyrrolidines; D003561:Cytarabine; D007608:Kainic Acid