Plasma concentrations of clomipramine and desmethylclomipramine in obsessive-compulsive neurosis.
Patients suffering from chronic obsessive-compulsive states were treated with clomipramine up to 200 mg/day according to tolerance for periods up to 8 months and their plasma clomipramine and desmethylclomipramine concentrations determined weekly by a double radioisotope derivative technique. Plasma concentrations of both the parent compound and its metabolite rose with dose and within 7-14 days of constant dosage reached steady states. A strong positive correlation was found between clomipramine, and to a lesser extent desmethylclomipramine, and the daily dose of clomipramine. In almost all patients plasma desmethylclomipramine concentrations exceeded those of unchanged drug by a factor of two or three.
D000293:Adolescent; D000328:Adult; D002997:Clomipramine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood* / Q000627:therapeutic use; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009771:Obsessive-Compulsive Disorder / Q000097:blood* / Q000188:drug therapy
D002997:Clomipramine