Effects of small medial preoptic area lesions on maternal behavior: retrieving and nest building in the rat.
Previous studies in rats have demonstrated that large lesions in the medial preoptic area (MPOA) disrupt all aspects of maternal behavior. In the present study, small bilateral electrolyte lesions in the MPOA of lactating females abolished nest building and retrieving components of maternal behavior while crouching and nursing were unaffected. Animals which failed to show retrieval and nest building behaviors tended to have a greater area of lesion within the more dorsal part of the MPOA. Although the dorsal MPOA may play a role in the maintenance of the active components of maternal behavior, i.e. nest building and retrieving, another critical factor in determining which components of maternal behavior are disrupted may be the size of the lesion. As one increases the area of damaged tissue there is also an accompanying increase in the components of maternal behavior which are disrupted. No correlation was found between damage to the Sexually Dimorphic Nucleus of the preoptic area and retrieving and nest building.
D000818:Animals; D001931:Brain Mapping; D005260:Female; D007031:Hypothalamus / Q000502:physiology*; D008425:Maternal Behavior; D009412:Nerve Fibers / Q000502:physiology; D009425:Nesting Behavior / Q000502:physiology*; D011247:Pregnancy; D011301:Preoptic Area / Q000502:physiology*; D051381:Rats