BN-183B, a new antitumor antibiotic produced by Pseudomonas. Taxonomy, isolation, physico-chemical and biological properties.
BN-183B is a new antitumor antibiotic with chlorine in its molecule found in the culture broth of Pseudomonas sp. BN-183. The compound was weakly basic and isolated as a hydrochloride in a pure state. The molecular formula of its free base was determined as C14H20N2O6Cl2. The antibiotic showed not only strong antimicrobial activity against both Gram-positive and Gram-negative bacteria but also marked activity toward experimental tumors such as lymphoid leukemia L-1210 and lymphocytic leukemia P-388 in mice. No mutagenicity of BN-183B was noted.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000633:toxicity; D001578:Benzopyrans; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D007928:Lethal Dose 50; D051379:Mice; D009153:Mutagens; D011549:Pseudomonas / Q000145:classification / Q000378:metabolism*; D013997:Time Factors
D000903:Antibiotics, Antineoplastic; D001578:Benzopyrans; D009153:Mutagens; C025268:bactobolin