title: Phase response to heat shock as evidence for a timekeeping oscillator in synchronous animal cells.
abstract: Synchronous animal cells given heat shocks at 0.5-h intervals through an 8.5-h cell cycle display a biphasic pattern of advances and delays in subsequent cell divisions. This phase-response curve to perturbation by heat shock has a period of approximately 4 h and cannot readily be explained by commonly used models of cell cycle traverse. We suggest that this outcome is the consequence of timekeeping by a macromolecular oscillator with limit cycle properties.
mesh_terms: D000818:Animals; D001683:Biological Clocks; D002453:Cell Cycle; D006224:Cricetinae; D003412:Cricetulus; D005347:Fibroblasts / Q000166:cytology; D006358:Hot Temperature; D008954:Models, Biological; D013997:Time Factors