[Experimental carcinogenesis in the urinary bladder against a background of Freund adjuvant and levamisole administration].
Administration of complete Freund's adjuvant (CFA) to rats before carcinogenesis and in its early period was associated with an increase (not less than 2-fold) in the number of spindle-shaped dark cells that permeated the hyperplastic urothelium and, judging the ultrastructure, had a macrophage nature. These animals demonstrated a relationship between the increased number of dark cells and delayed development of the subsequent stage of carcinogenesis--papillomatous hyperplasia. CFA administration to the animals with a developed cancer of the urinary bladder did not affect it noticeably. It did not produce any effect on subcutaneous transplantation of cancer that had taken in 100% of cases. No morphological features of carcinogenesis were recorded either after levamisol administration. However, none of the tumours withdrawn from the rats given levamisol took under the skin of the recipients.
D000818:Animals; D000970:Antineoplastic Agents; D002085:Butylhydroxybutylnitrosamine / Q000037:antagonists & inhibitors*; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D005620:Freund's Adjuvant / Q000627:therapeutic use*; D007978:Levamisole / Q000627:therapeutic use*; D008297:Male; D009374:Neoplasms, Experimental; D009602:Nitrosamines / Q000037:antagonists & inhibitors*; D010212:Papilloma / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced* / Q000473:pathology
D000970:Antineoplastic Agents; D009602:Nitrosamines; D007978:Levamisole; D002085:Butylhydroxybutylnitrosamine; D005620:Freund's Adjuvant
Eksperimental'nyĭ kantserogenez v mochevom puzyre na fone vvedeniia ad'iuvanta Freĭnda i levamizola.