Failure to demonstrate renal uptake of labelled platelets in chronic glomerulonephritis.
1. Renal localization of autologous 111In-labelled platelets was studied in patients with chronic glomerulonephritis. External imaging was performed with a gamma-camera fitted with a medium energy collimator and the images were collected by a computer. 2. Images of 111In-labelled platelet distribution showed that there was a marked contribution to the radioactivity within each renal silhouette from adjacent spleen or liver. It was not possible to demonstrate renal accumulation of 111In-labelled platelets. 3. The application of 111In-labelled platelets to the study of intrarenal platelet consumption in chronic glomerulonephritis is limited by the sensitivity of current techniques and the scatter from adjacent splenic and hepatic radioactivity.
D000328:Adult; D001792:Blood Platelets / Q000502:physiology*; D002470:Cell Survival; D002908:Chronic Disease; D005921:Glomerulonephritis / Q000503:physiopathology*; D006801:Humans; D007204:Indium; D007668:Kidney / Q000503:physiopathology*; D011868:Radioisotopes
D011868:Radioisotopes; D007204:Indium