Vasoactive intestinal polypeptide (VIP) inhibits prostaglandin-F2 alpha-induced activity of the rabbit myometrium.
Seven female rabbits ahd myometrial autografts transplanted into ear-chambers. The electrical activity of the graft was recorded and mechanical activity observed. Vasoactive intestinal polypeptide (VIP) dose-dependently inhibited myometrial activity induced by prostaglandin-F2 alpha. This evidence and the occurrence of "VIPergic" nerve fibres, which seem to innervate the myometrial cells, suggest that VIP may play a physiological role in the local control of the myometrial activity.
D000818:Animals; D005260:Female; D005768:Gastrointestinal Hormones / Q000494:pharmacology*; D009215:Myometrium / Q000294:innervation / Q000637:transplantation; D009412:Nerve Fibers / Q000187:drug effects; D011460:Prostaglandins F / Q000037:antagonists & inhibitors*; D011817:Rabbits; D014182:Transplantation, Autologous; D014590:Uterine Contraction / Q000187:drug effects*; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology* / Q000502:physiology
D005768:Gastrointestinal Hormones; D011460:Prostaglandins F; D014660:Vasoactive Intestinal Peptide