Potential prophylactic antitumor activity of retinylidene 1,3-diketones.
Treatment of all-trans-retinal with a series of 1,3-diketones using Knoevenagel conditions gave the expected condensation products. These retinylidene 1,3-diketones were characterized and their biological activities in the hamster tracheal organ culture test measured. It was found that the cyclohexane- 1,3-dione derivatives are highly active in this in vitro assay, while other 1,3-diketones are less active. Retinylidenedimedone has been chosen for further evaluation.
D000818:Animals; D002454:Cell Differentiation / Q000187:drug effects; D006224:Cricetinae; D004847:Epithelial Cells; D004848:Epithelium / Q000187:drug effects; D007659:Ketones / Q000138:chemical synthesis / Q000494:pharmacology; D009369:Neoplasms / Q000517:prevention & control; D009924:Organ Culture Techniques; D012172:Retinaldehyde / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D014132:Trachea; D014801:Vitamin A / Q000031:analogs & derivatives*
D007659:Ketones; D014801:Vitamin A; D012172:Retinaldehyde