title: Fine structure of ependymal cysts in and around the area postrema of the rat.
abstract: Peculiar cells forming cysts were observed in the area postrema and sometimes also in the choroid plexus and the tela chorioidea near the area postrema, and were studied in detail by electron microscopy. The cytological features of the cyst cell and its junctional relationship to neighboring cells imply that cyst cells are derived from ependymal and choroid epithelial cells. The cyst cells usually contact directly the perivascular spaces of postremal, choroidal or pial capillaries, where the cytoplasm is often considerably attenuated. The cystic lumen is commonly filled with a flocculent material. The limiting membrane of the cystic lumen, which frequently bears cilia and microvilli, has the same thickness as the surface cell membrane. In many cases the cyst is surrounded by the cytoplasm of a single cell. In some cases, however, two cells participating in the formation of the cyst, although one is only a slender process and joined by a zonula occludens with the main cyst cell. Horseradish peroxidase (HRP) injected into the cerebrospinal fluid (CSF) space failed to enter the cystic lumen. A possible significance of the cyst in relation to the CSF and blood circulation was considered.
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D002552:Cerebral Ventricles / Q000648:ultrastructure; D002831:Choroid Plexus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D004805:Ependyma / Q000378:metabolism / Q000648:ultrastructure*; D005260:Female; D006735:Horseradish Peroxidase / Q000378:metabolism; D007365:Intercellular Junctions / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009940:Organoids / Q000648:ultrastructure; D051381:Rats
chemical_list: D006735:Horseradish Peroxidase