[The use of histo-scintigraphic correlations in the detection of osteomedullary metastases secondary to visceral neoplasms (author's transl)].
Disagreement has been observed between the results of bone scan using technetium polyphosphate interpreted quantitatively by local counting and the results of bone-marrow biopsy. This led us to demonstrate the possibility of rare "false-negatives" on histopathological examination related to faulty technique in histological preparations. These "false-negatives" (5 cases ot of 166 biopsies examined) would not appear to require a need for exhaustive examination of all specimens. We therefore suggest that the results of isotopic bone scan should be taken into account in the determination of the technique which should be used in the preparation of sections for histological examination of the biopsy. If the quantitative scan is doubtful or positive, the first four levels of sectins taken every 100 microns in the mounting block should be examined first. If these first four levels are negative, the whole of the remainder of the block is examined and sections are taken every 100 microns (i.e. 15 to 20 sections per case). When quantitative scan is negative, the standard technique of examination of 3 to 4 levels of sections distributed throughout the block seems to be adequate.
D001706:Biopsy; D001853:Bone Marrow / Q000473:pathology*; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D005188:False Negative Reactions; D006801:Humans; D011877:Radionuclide Imaging
Intérêt des confrontations histo-scintigraphiques dans le dépistage des localisations osseuses secondaires des cancers viscéraux.