Is propylene glycol an inert substance?
The effect of 30 day administration of undiluted propylene glycol (1,2-propanediol, PG) on plasma and liver lipids was studied in adult male Sprague-Dawley rats. When compared with the control group no significant difference was observed in plasma concentration of total phospholipids, cholesterol, triglycerides and free fatty acids, and in liver concentration of phospholipids, triglycerides and gangliosides. Liver total cholesterol was moderately, but significantly, increased.
D000818:Animals; D002784:Cholesterol / Q000096:biosynthesis; D005230:Fatty Acids, Nonesterified / Q000096:biosynthesis; D005732:Gangliosides / Q000096:biosynthesis; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects*; D008297:Male; D010743:Phospholipids / Q000097:blood; D019946:Propylene Glycol; D011409:Propylene Glycols / Q000494:pharmacology*; D051381:Rats; D014280:Triglycerides / Q000096:biosynthesis
D005230:Fatty Acids, Nonesterified; D005732:Gangliosides; D010743:Phospholipids; D011409:Propylene Glycols; D014280:Triglycerides; D019946:Propylene Glycol; D002784:Cholesterol