Chloramphenicol levels in cerebrospinal fluid in meningitis.
Chloramphenicol was found to cross the blood-brain barrier into the cerebrospinal fluid of children with pyogenic meningitis effectively both at days 2 and 10 of therapy. It is recommended as the drug of choice in the treatment of children with Haemophilus influenzae meningitis.
D001812:Blood-Brain Barrier / Q000187:drug effects; D002648:Child; D002701:Chloramphenicol / Q000097:blood / Q000134:cerebrospinal fluid* / Q000627:therapeutic use; D006801:Humans; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000188:drug therapy; D008583:Meningitis, Haemophilus / Q000188:drug therapy; D011008:Pneumococcal Infections / Q000188:drug therapy; D013997:Time Factors
D002701:Chloramphenicol