The effects of aluminum on microtubular integrity using in vitro and in vivo models.
Since neuronal lesions produced by aluminum (Al) are morphologically similar to lesions produced by microtubule inhibitors, the effect of aluminum on microtubule integrity was investigated. Aluminum inhibited microtubule formation at concentrations as low as 0.1 mM. This approaches the aluminum concentrations found in brains of patients with several disorders which result in progressive dementia.
D000535:Aluminum / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000648:ultrastructure; D056890:Eukaryota / Q000648:ultrastructure; D066298:In Vitro Techniques; D008870:Microtubules / Q000187:drug effects*; D011817:Rabbits
D000535:Aluminum