Influence of immunosuppressive pretreatment on the survival of mice challenged with Ehrlich ascites carcinoma (EAC).
Mice were pretreated with immunosuppressive doses of cyclophosphamide (CY), cortisone acetate (CA) or X-irradiation. 24 h later all mice were given 1 x 10(5) EAC cells intraperitoneally. In another experiment mice were splenectomized 1 h before injection of EAC cells. Neither CY nor CA pretreatment had significant influence on the survival of tumor-inoculated mice. On other hand, X-irradiation or splenectomy strengthened tumor resistance.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000276:immunology* / Q000401:mortality; D003348:Cortisone / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D007165:Immunosuppression Therapy; D008297:Male; D051379:Mice; D013156:Splenectomy; D014965:X-Rays
D003520:Cyclophosphamide; D003348:Cortisone