Antagonism of pentobarbitone sleep by dopamine, levodopa and apomorphine in chicks.
1. The influence of dopamine, levodopa and apomorphine on sleep produced by pentobarbitone was studied in 1-14 day old chicks. 2. Pentobarbitone-induced sleep was associated with synchronization of the electroencephalogram (EEG) of the hyperstriatum, optic tectum and pontine reticular formation. 3. Dopamine desynchronized the EEG and antagonized pentobarbitone-induced EEG synchronization. 4. High doses of dopamine produced a delayed sleep which was potentiated by pimozide and antagonized by adrenoreceptor blocking agents. 5. Dopamine, levodopa and apomorphine delayed the onset and shortened the duration of pentobarbitone-induced sleep; apomorphine was the most potent. 6. Pimozide prolonged the duration of pentobarbitone-induced sleep, but had less effect when dopamine was also given.
D000375:Aging; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D002645:Chickens; D004298:Dopamine / Q000494:pharmacology*; D004567:Electrodes, Implanted; D004569:Electroencephalography; D004576:Electromyography; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D010424:Pentobarbital / Q000037:antagonists & inhibitors*; D010868:Pimozide / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*
D010868:Pimozide; D007980:Levodopa; D010424:Pentobarbital; D001058:Apomorphine; D004298:Dopamine