Effect of oral contraceptives on vitamin B6 nutriture of young women.
The effect of oral contraceptives (OC) on vitamin B6 status of young women was assessed by percentage stimulation of erythrocyte glutamic pyruvic transaminase (EGPT) activity. The subjects were studied under three groups--control (non OC users), cross-sectional study group (taking OC for over a period of 3 months) and follow up study group. No adverse effect of OC on mean basic EGPT, mean percentage stimulation level or in the incidence of deficiency was noted in cross-sectional study group as compared to controls. Similarly follow up of women before the initial of OC therapy and after a period of 3 months or 6 months usage also demonstrated no adverse effects on vitamin B6 nutriture. The vitamin B6 status showed no relationship with duration of OC use. Dietary vitamin B6 was below the recommended in majority of cases and showed no significant correlation with percentage stimulation of EGPT.
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003277:Contraceptives, Oral, Combined / Q000494:pharmacology; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology*; D004338:Drug Combinations; D004912:Erythrocytes / Q000201:enzymology; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D019304:Ethinyl Estradiol-Norgestrel Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008656:Mestranol / Q000494:pharmacology*; D009640:Norethindrone / Q000494:pharmacology*; D009644:Norgestrel / Q000494:pharmacology*; D009751:Nutritional Requirements; D011736:Pyridoxine / Q000378:metabolism*; D013997:Time Factors
D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D003280:Contraceptives, Oral, Synthetic; D004338:Drug Combinations; D009644:Norgestrel; D004997:Ethinyl Estradiol; C014715:Norinyl; D019304:Ethinyl Estradiol-Norgestrel Combination; D008656:Mestranol; D000410:Alanine Transaminase; D011736:Pyridoxine; D009640:Norethindrone