Human fatty marrow aromatizes androgen to estrogen.
Human female fatty marrow from the femur and iliac crest has the ability to convert androgen to estrogen. Homogenates of fatty marrow incubated with 19-[6,7-3H]hydroxyandrostenedione (19-hydroxyandrost-4-ene-3,17-dione) and an NADPH-generating system produced estrogen in all six samples. The major estrogen produced in five of the cases was [3H]estrone, the immediate product of the aromatizaton of 19-hydroxyandrostenedione. One case produced [3H]estradiol. The local formation of estrogens in bone marrow may be important to the closure of the epiphyses at puberty and may affect osteoporosis at the menopause.
D000735:Androstenedione / Q000031:analogs & derivatives* / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism*; D004958:Estradiol / Q000096:biosynthesis; D004967:Estrogens / Q000096:biosynthesis*; D004970:Estrone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D014316:Tritium
D004967:Estrogens; D014316:Tritium; D004970:Estrone; D000735:Androstenedione; D004958:Estradiol; C011482:19-hydroxy-4-androstene-3,17-dione