[Cardiovascular changes caused by atropine in epidural-, halothane- and neuroleptanaesthesia (author's transl)].
The authors could verify the heart rate increasing effect of atropine. The different sympathetic and parasympathetic activity caused by the method of operation and the kind of anaesthesia had a modifying effect on the heart frequency increase. In contrast to a small heart rate increase in halothaneanaesthesia, the increase in epidural- and neuroleptanaesthesia was higher. In addition medical treatment with pancuronium modified the effect of atropine. The frequency increase in patients who had got pancuronium was significantly smaller - the basic rate being higher - than in patients who hadn't got pancuronium. Those patients reacted vice versa. The authors found out that by giving 1 mg of atropine a maximum effect could be expected and that there couldnt be spoken of an overdosage.
D000767:Anesthesia, Epidural; D000769:Anesthesia, Inhalation; D001011:Aorta / Q000601:surgery; D001285:Atropine / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002496:Central Venous Pressure / Q000187:drug effects; D004347:Drug Interactions; D005263:Femoral Artery / Q000601:surgery; D006221:Halothane / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D008875:Middle Aged; D009458:Neuroleptanalgesia; D010197:Pancuronium / Q000494:pharmacology; D012501:Saphenous Vein / Q000601:surgery; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D001285:Atropine; D010197:Pancuronium; D006221:Halothane
Veränderung der Herzkreislauffunktion in Epiduralanästhesie, Halothannarkose und Neuroleptanästhesie durch Atropin.