Treatment of NZB/W ("lupus") mice with 15(S)-15 methyl PGE1.
The F1 hybrid of New Zealand black and New Zealand white mice--the NZB/W mouse--spontaneously develops a disease similar to human systemic lupus erythematosus. Male NZB/W mice with established disease were treated with a stable derivative of prostaglandin E1, 15(S)-15 methyl PGE1 (4 micrograms twice daily) from 7 months of age. The pge analog prolonged survival of these mice: At 14 months 7 of 10 control mice had died, whereas 9 of 10 15(S)-15 methyl PGE1 treated mice remained alive. Thus a dose of 200 micrograms/Kg/day 14(S)-15 methyl PGE1 retards progression of murine lupus.
D000527:Alprostadil / Q000031:analogs & derivatives*; D000818:Animals; D004195:Disease Models, Animal; D006824:Hybridization, Genetic; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D051379:Mice; D011459:Prostaglandins E, Synthetic / Q000627:therapeutic use*
D011459:Prostaglandins E, Synthetic; C025170:15(S)-15-methylprostaglandin E1; D000527:Alprostadil