title: Inappropriate use of albino animals as models in research.
abstract: Sensory-neural, biochemical-metabolic, and physiological anomalies occur in albino mammals. There are ontogenic and biochemical parallels between the senses, peripheral nervous system, endocrine glands, metabolism, and melanin pigmentation. All albino mammals examined have abnormal optic systems. Many drugs cannot be adequately evaluated in an albino model because of melanin's ability to bind and interact with some chemicals. There is evidence that a general reduction in melanin pigment is correlated with a paucity of amino acids necessary for normal chemical function of the brain. There is a high probability that enzyme levels indicative of metabolic performance are deficient in the liver and kidneys oif albinos. Congenital defects are associated with hypopigmentation in animal models and human syndromes. Melanin is found in abundance in the eye, inner ear, and midbrain where neural impulses are initiated indicating a possible role as an electrophysiologic mechanism. Microwave irradiation differentially affects albino and pigmented animals. Implications of these observations and other reports of anomalies associated with hypopigmentation suggest caution in the use of albino and other hypomelanotic animals as normal models in biological research.
mesh_terms: D000417:Albinism / Q000378:metabolism / Q000503:physiopathology* / Q000523:psychology; D000818:Animals; D000830:Animals, Laboratory; D001303:Auditory Cortex / Q000502:physiology; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008543:Melanins / Q000502:physiology; D009432:Neural Crest / Q000502:physiology; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010858:Pigmentation; D010859:Pigmentation Disorders / Q000503:physiopathology; D011984:Sensory Receptor Cells / Q000502:physiology; D014786:Vision Disorders / Q000503:physiopathology
chemical_list: D008543:Melanins; D004364:Pharmaceutical Preparations