Naloxone reduces fluid intake: effects of water and food deprivation.
Food and fluid deprived and nondeprived male rats showed 36% and 46% decreases, respectively, in sucrose consumption 15-min after injection with 2 mg/kg of naloxone in one hr tests. The magnitude of this decrease was not correlated with an index of naloxone's ability to produce a sickness, as measured by the conditioned taste aversion test. Tests with animals scheduled to drink water in a 15-min daily session showed naloxone had similar effects in reducing water intake in 23-hr and 47-hr water deprived rats. Morphine, when self-administered, produced an increase in water intake during 6-hr sessions. The data support the idea that naloxone disrupts a component of normal regulation of ingestion.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004327:Drinking Behavior / Q000187:drug effects*; D005508:Food Deprivation / Q000502:physiology*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D051381:Rats; D014868:Water Deprivation / Q000502:physiology*
D009270:Naloxone