[Participation of bone marrow stromal precursor cells and bone regeneration during transosseous osteosynthesis].
Changes in the proliferative activity and in the number of bone marrow stromal precursor cells (SPC) in the dog long bone fixed with Ilizarov's apparatus were studied by cloning in monolayer cultures over a period of leg lengthening. It was demonstrated that in 1-1 1/2-year-old dogs the number of dividing SPC in the tibia increased up to 95% by termination of the distraction (60 days). Concurrently, the colony-forming efficiency (CFE) increased 11-fold. In the contralateral tibia (CFE significantly rose during the distraction, while in the humeri it decreased 2.5-fold as compared to control. A conclusion is drawn about participation of SPC in bone regeneration.
D000818:Animals; D001853:Bone Marrow / Q000503:physiopathology*; D003114:Colony-Forming Units Assay; D004285:Dogs; D005260:Female; D050723:Fractures, Bone / Q000503:physiopathology*; D008297:Male; D013978:Tibial Fractures / Q000503:physiopathology; D014945:Wound Healing
K voprosu ob uchastii stromal'nykh kletok-predshestvennikov kostnogo mozga i regeneratsii kosti pri chreskostnom osteosinteze.