title: Molecular characterization of HLA-A, B homologues in owl monkeys and other nonhuman primates.
abstract: Mouse anti-HLA-A, B monoclonal antibodies have been used to study the homologues of HLA-A, B antigens in other primate species. Immunoprecipitates of primate histocompatibility antigens from extracts of radioactively labeled lymphocytes were analyzed by SDS-polyacrylamide electrophoresis. Primate histocompatibility antigens appear to have similar molecular structure to human HLA antigens. Owl monkeys, which react polymorphically with some monomorphic anti-HLA antibodies, showed biochemical differences which correlated with the serological polymorphism. An antibody (W6/32) which only reacts with the HLA/beta 2-microglobulin complex in humans and not with the free HLA heavy chain has the reverse specificity in some owl monkeys.
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D001029:Aotus trivirgatus / Q000276:immunology*; D002427:Cebidae / Q000276:immunology*; D055598:Chemical Phenomena; D002621:Chemistry; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006649:Histocompatibility Antigens / Q000235:genetics / Q000276:immunology; D006801:Humans; D006922:Hylobates; D008252:Macaca fascicularis; D008253:Macaca mulatta; D011233:Precipitin Tests; D013045:Species Specificity
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens