Turnover of enzymes of peroxisomal beta-oxidation in rat liver.
Male Wistar rats were given a diet containing 2% (w/w) di-ethylhexyl)-phthalate (DEHP), a peroxisomal proliferator, for 4 weeks. The activities of enzymes of peroxisomal beta-oxidation and of catalase were markedly increased by the DEHP administration. The time required to reach halfway to the maximal induction for enzymes of peroxisomal beta-oxidation was 5--7 days, whereas that for catalase was 3 days. A separate DEHP group was placed on the control diet after 14 days of feeding with the DEHP diet. On the withdrawal of DEHP, activities of enzymes of the beta-oxidation system and of catalase decreased to the control levels with a half-life of 2--3 days. Responses of some mitochondrial enzymes involved in fatty acid oxidation are also described.
D000818:Animals; D001835:Body Weight; D002374:Catalase / Q000096:biosynthesis; D004051:Diethylhexyl Phthalate / Q000008:administration & dosage / Q000494:pharmacology; D004790:Enzyme Induction; D008099:Liver / Q000201:enzymology*; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000201:enzymology*; D009940:Organoids / Q000201:enzymology*; D010084:Oxidation-Reduction; D051381:Rats
D004051:Diethylhexyl Phthalate; D002374:Catalase