Clearance of immune complexes formed in normal and leukaemic rats.
Immune complexes of 125I-HSA-rat anti-HSA formed in vivo under conditions of antibody excess were rapidly cleared from the circulation of both normal and leukaemic Hooded rats. In HSA-immune rats most of the 125I-HSA present in the blood was found to be cell-bound, but a proportion was present as circulating immune complexes that could be precipitated from plasma by 2.5% polyethylene glycol. There was no evidence that clearance of a soluble antigen was impaired in leukaemic animals.
D000818:Animals; D000936:Antigen-Antibody Complex; D007942:Leukemia, Experimental / Q000276:immunology* / Q000378:metabolism; D008657:Metabolic Clearance Rate; D011092:Polyethylene Glycols; D051381:Rats; D012711:Serum Albumin, Radio-Iodinated / Q000276:immunology / Q000378:metabolism
D000936:Antigen-Antibody Complex; D012711:Serum Albumin, Radio-Iodinated; D011092:Polyethylene Glycols