Data on sisomicin effect: human pharmacokinetic and bacteriological studies.
Antibiotic sensitivity of bacteria cultured from 1020 pulmonological, medical and surgical cases was determined. Inhibitory effect on the bacterial growth was observed most frequently with sisomicin among the antibiotics of aminoglycoside type. Sisomicin levels were studied in the serum and lung tissue in 20 cases of pulmonary operations. Fifty to ninety minutes subsequent to an intramuscular administration of 1 mg sisomicin per 1 kg body weight, the serum levels amounted to 4.0 mcg/ml, whereas the apparently healthy, the inflamed and tumourous parts of the removed lung tissue contained 2.2, 1.2 and 0.2 mcg/g. The serum level remained unchanged even after 110-150 min, when the lung tissue levels were 3.0, 1.5 and 2.1 mcg/g. The sisomicin concentrations found in the lung tissue are of bactericid effect only against a part of the bacteria studied. This fact emphasizes the importance of exact indication and use of doses of sisomicin.
D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D005260:Female; D005839:Gentamicins / Q000494:pharmacology*; D006801:Humans; D007700:Kinetics; D008168:Lung / Q000378:metabolism; D008175:Lung Neoplasms / Q000378:metabolism; D008297:Male; D012853:Sisomicin / Q000097:blood / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D012853:Sisomicin