title: Control of heparinisation during cardiopulmonary bypass. Experience with the activated clotting time method.
abstract: A rational approach to the control of heparinisation during open heart surgery is advocated. Some of the possible and potential shortcomings of the time-based heparin protocols in current use are presented. The use of a recent, simple automated device 'Hemochron' to estimate the Activated Clotting Time is described and it is found to be an economical and efficient method to monitor heparinisation during cardiopulmonary bypass.
mesh_terms: D000328:Adult; D002315:Cardiopulmonary Bypass; D004334:Drug Administration Schedule; D004697:Endocarditis, Bacterial / Q000097:blood; D006493:Heparin / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007423:Intra-Aortic Balloon Pumping; D008991:Monitoring, Physiologic / Q000379:methods; D011479:Protamines / Q000627:therapeutic use; D014914:Whole Blood Coagulation Time
chemical_list: D011479:Protamines; D006493:Heparin