In-vivo inhibition by copper and some Cu-complexes of paracetamol-induced lipid peroxidation in benzpyrene-pretreated mice.
Benzo(alpha)pyrene-induced male mice were treated with 200 mg/kg paracetamol. The ethane exhalation of the animals was taken as an in-vivo index of lipid peroxidation: it amounted to 420  98 nmoles of ethane/kg body weight after 4 hours. A dose of 10 mg/kg of bovine superoxide dismutase had no effect on lipid peroxidation. After 4 daily repeated i.p. injections of 5 mg/kg copper-tyrosine or copper-asprinate an inhibition of the ethane exhalation was observed by 97 %. Control experiments indicated that Cu SO4 and tyrosine alone inhibited this drug-induced lipid peroxidation by 21 % and 24 %, respectively. However, the copper-ethylendiamine tetraacetic acid complex was also effective. The experiments show that in vivo various copper compounds effectively depress this type of drug-induced lipid peroxidation at low concentrations.
D000082:Acetaminophen / Q000494:pharmacology*; D000818:Animals; D001580:Benzopyrenes / Q000494:pharmacology*; D001711:Biotransformation; D003300:Copper / Q000494:pharmacology*; D004980:Ethane / Q000378:metabolism; D008054:Lipid Peroxides / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D051379:Mice; D014443:Tyrosine / Q000494:pharmacology
D001580:Benzopyrenes; D008054:Lipid Peroxides; D000082:Acetaminophen; D014443:Tyrosine; D003300:Copper; D004980:Ethane