Single oral dose pharmacokinetics of clomipramine in depressed patients.
The pharmacokinetics of a single oral dose of clomipramine were examined in a group of depressed patients, 8 female and 2 male with a mean age of 51 years (range 21-78). Their mean clomipramine half-life was 36 hours and mean plasma clomipramine clearance 73 litres per hour, with a wide range in each case. These results differ from those previously reported in volunteer subjects, who had shorter clomipramine half-lives. Pharmacokinetic studies should therefore be performed in patients undergoing treatment, rather than healthy volunteers.
D000284:Administration, Oral; D000328:Adult; D000368:Aged; D002997:Clomipramine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D003863:Depression / Q000097:blood / Q000378:metabolism*; D004334:Drug Administration Schedule; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged
D002997:Clomipramine