Dexamethasone enhancement of the induction of cells bearing receptors for IgM in human peripheral blood lymphocyte culture.
Using a low density culture technique which allows normal human peripheral blood T cells to proliferate actively in vitro when stimulated by mitogens, it is shown that dexamethasone enhances the spontaneous induction of cells bearing receptors for the Fc of IgM. Dexamethasone has no effect on the induction of cells bearing receptors for the Fc of IgG.
D002478:Cells, Cultured; D003907:Dexamethasone / Q000494:pharmacology*; D006801:Humans; D007075:Immunoglobulin M / Q000378:metabolism*; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology*; D008938:Mitosis / Q000187:drug effects; D011961:Receptors, Fc / Q000096:biosynthesis* / Q000187:drug effects; D012397:Rosette Formation
D007075:Immunoglobulin M; D011961:Receptors, Fc; D003907:Dexamethasone