Tryptophan pyrrolase in haem regulation. The mechanism of the permissive effect of cortisol on the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide in the adrenalectomized-rat liver.
The decreased ability of 2-allyl-2-isopropropylacetamide to enhance liver 5-amino-laevulinate synthase activity in the adrenalectomized rat is not associated with a marked depletion of the already low amount of tryptophan pyrrolase haem. Cortisol permits the porphyrogen markedly to enhance synthase activity by rendering it capable of causing a stronger depletion of pyrrolase haem, presumably as result of hormonal induction of pyrrolase synthesis.
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism*; D000315:Adrenalectomy; D000493:Allopurinol / Q000494:pharmacology; D000502:Allylisopropylacetamide / Q000494:pharmacology; D000818:Animals; D006418:Heme / Q000378:metabolism*; D006854:Hydrocortisone / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D051381:Rats; D014366:Tryptophan Oxygenase / Q000378:metabolism*
D000502:Allylisopropylacetamide; D006418:Heme; D000493:Allopurinol; D014366:Tryptophan Oxygenase; D000624:5-Aminolevulinate Synthetase; D006854:Hydrocortisone