title: [Morphology of experimental acute pancreatitis during treatment with 5-fluorouracil].
abstract: Application of 5-fluorouracil exerts a noticeable therapeutic effect in experimental pancreatitis induced according to the modified technique. It prevents the development of acinus necrosis and suppurative lysis of the gland tissue. A suggestion is made that the therapeutic effect of 5-fluorouracil is related to its inhibitory action on RNA synthesis and to the blockade of secretion release from the exocrine part of the gland.
mesh_terms: D000208:Acute Disease; D000818:Animals; D005472:Fluorouracil / Q000627:therapeutic use*; D008297:Male; D009336:Necrosis; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000188:drug therapy* / Q000473:pathology; D051381:Rats
chemical_list: D005472:Fluorouracil
vernacular_title: Morfologiia éksperimental'nogo ostrogo pankreatita pri lechenii 5-ftoruratsilom.