Reversible dermal atrophy in a cat treated with phenytoin.
Phenytoin, given to a cat in proportions therapeutic for man (5 to 8 mg/kg), induced severe dermal atrophy with excessive fragility of the skin following daily oral administration for 3 weeks. Dermal collagen was depleted, but remaining collagen seemed structurally normal. Upon cessation of phenytoin treatment, the cat recovered. In an effort to establish an association between phenytoin treatment and a dermal collagen disorder, phenytoin treatment was repeated and the dermal lesion confirmed.
D000284:Administration, Oral; D000818:Animals; D001284:Atrophy; D002371:Cat Diseases / Q000139:chemically induced* / Q000473:pathology; D002415:Cats; D003095:Collagen Diseases / Q000139:chemically induced / Q000473:pathology / Q000662:veterinary; D008297:Male; D010672:Phenytoin / Q000008:administration & dosage / Q000009:adverse effects*; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000473:pathology / Q000662:veterinary*
D010672:Phenytoin