[Changes in the adrenergic regulation of thermogenesis during prolonged rat adaptation to cold].
Comparison of effects of catecholamines (noradrenaline, adrenaline, and isopropyl-noradrenaline) on oxygen consumption and body temperature and study of influence of beta- and alpha-adrenergic blocking agents (poropranolol and phentolamine) on their calorigenic effects in cold- and warm-adapted rats revealed that affinity of propranolol and all the catecholamines to beta-adrenoreceptors is enhanced. Influence of propranolol on the cold thermogenesis involves thermoregulatory metabolism decrease in warm-adapted rats and additional (compensatory) increase of thermoregulatory electrical muscle activity in cold-adapted rats. The sympathetic regulation of heat production and its changes at prolonged cold adaptation seem to be mainly of beta-adrenergic nature.
D000064:Acclimatization; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects; D003080:Cold Temperature; D004837:Epinephrine / Q000494:pharmacology; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009334:Neck Muscles / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology*
D011433:Propranolol; D007545:Isoproterenol; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine
Izmeneniia adrenergicheskoĭ reguliatsii termogeneza pri dolgovremennoĭ adaptatsii krys k kholodu.