title: Evidence in man that cigarette smoking induces vasopressin release via an airway-specific mechanism.
abstract: The plasma vasopressin response to intravenous nicotine (2 mg) and smoking cigarettes of high (1.2 mg) and low (0.6 mg) nicotine content was studied in healthy young subjects with a history of cigarette smoking. Nicotine administered intravenously had no effect on plasma vasopressin. There was a statistically significant increase in plasma vasopressin after both the low and high content cigarettes, with the high content cigarettes resulting in a significantly greater increase. All three interventions resulted in transient increases in blood pressure and pulse of similar magnitude. These studies indicate that cigarette smoking-induced vasopressin release is not mediated via an action of circulating nicotine, and suggest the presence of an airway-specific mechanism for vasopressin release.
mesh_terms: D000328:Adult; D006801:Humans; D008168:Lung / Q000187:drug effects; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D012907:Smoking; D014667:Vasopressins / Q000097:blood*
chemical_list: D014667:Vasopressins; D009538:Nicotine