The effect of hydroxyurea and mitomycin C on sperm motility in mice.
The mutagen, mitomycin C, and the teratogen, hydroxyurea, were found to decrease sperm motility in mice in a dose-dependent manner. Positive results with these compounds suggest that sperm motility may have been decreased through either mutations or developmental disturbances. Sperm motility can be determined quickly and may be done in conjunction with a sperm-morphology assay.
D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D006918:Hydroxyurea / Q000494:pharmacology*; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008937:Mitomycins / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000502:physiology
D008937:Mitomycins; D006918:Hydroxyurea