In vitro fertilization of hamster eggs as a test system for drug effect on spermatozoa--lack of clomipramine effect.
Clomipramine may affect reproduction in male rats and dogs, while other psychotropic drugs can affect sperm motility in vitro. This study investigates the motility of hamster sperm and the fertilization of hamster eggs in vitro with epididymal sperm from alpha-chlorohydrin-pretreated males, and after preincubation with clomipramine. Alpha-chlorohydrin, a compound with a predicted antifertility action, decreased sperm motility and prevented in vitro fertilization. In contrast, clomipramine had no effect on sperm motility, including activated motility, on the acrosome reaction, or on egg penetration in vitro. Clomipramine can, however, influence prolactin levels in man, and follicle-stimulating and luteinizing hormone levels in male rats.
D000818:Animals; D002997:Clomipramine / Q000494:pharmacology*; D006224:Cricetinae; D005307:Fertilization in Vitro / Q000187:drug effects*; D008297:Male; D013081:Sperm Motility / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects*; D013997:Time Factors; D000517:alpha-Chlorohydrin / Q000494:pharmacology
D000517:alpha-Chlorohydrin; D002997:Clomipramine