The effect of oral prednisolone on gas exchange in chronic bronchial asthma.
Patients with bronchial asthma frequently have a fall in arterial oxygen tension following bronchodilator treatment in spite of a reduction in airway resistance. Administration of 0.11 mM (40 mg) prednisolone in a single dose resulted in an improvement of both airway obstruction and hypoxaemia in chronic asthmatic patients. The arterial oxygen tension, alveolar-arterial oxygen tension difference and venous admixture effect all showed a statistically significant improvement as did the dynamic lung volumes and specific airway conductance.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000402:Airway Obstruction / Q000188:drug therapy; D001249:Asthma / Q000188:drug therapy*; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D011239:Prednisolone / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D012119:Respiration / Q000187:drug effects*
D011239:Prednisolone; D010100:Oxygen