[Immunosuppressive effect of lysosomal factors in the liver (author's transl)].
A lysosomal factor isolated from liver tissue (LF) reveals a strong suppressive effect on the in vitro immune response. LF is not species specific and is able to act specifically on the responder function of mitogen or alloantigen-mediated lymphocyte proliferation. The peculiar immunological feature of the liver that it induces a pronounced immunological hyporeactivity can be explained by a similar effect of LF on the cellular immune response in vivo which leads to a reduced rejection of the allotransplanted organ.
D000818:Animals; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007166:Immunosuppressive Agents / Q000032:analysis*; D008099:Liver / Q000276:immunology*; D008247:Lysosomes / Q000276:immunology*; D051379:Mice; D013552:Swine
D007166:Immunosuppressive Agents
Der immunsuppressive Effekt lysosomaler Faktoren in der Leber.