[Triterpene glycosides with antifungal activity isolated from the sea cucumber, Cucumaria japonica].
A complex of triterpenic oligoglycosides or cucumariosides was isolated from the skin-muscular sac of Cucumaria japonica. The complex includes at least 7 components. Fractionation of the complex on lyophilized sephadex LH-20 resulted in quantitative isolation of its 2 main components, i.e. cucumariosides I and II in a chromatographically pure state. The part of these glucosides in the native mixture of cucumariosides was 65 and 20% respectively. The complex inhibited the growth of Candida albicans and C. tropicalis in concentrations of 50 microgram/ml. Cucumarioside II inhibited the growth of the above organisms in a concentration of 60 microgram/ml. The MIC of I for these organisms was 30 and 40 microgram/ml respectively.
D000818:Animals; D000935:Antifungal Agents; D002855:Chromatography, Thin Layer; D004447:Echinodermata; D006027:Glycosides / Q000302:isolation & purification*; D012503:Saponins / Q000302:isolation & purification; D012616:Sea Cucumbers; D014315:Triterpenes / Q000302:isolation & purification*
D000935:Antifungal Agents; D006027:Glycosides; D012503:Saponins; D014315:Triterpenes
Triterpenovye glikozidy s antigribkovoĭ aktivnostiu, vydelennye iz morskoĭ kubyshki Cucumaria japonica.