The metabolic N-oxidation of 3-substituted pyridines in various animal species in vivo.
The intraperitoneal administration of pyridine, 3-methylpyridine and 3-chloropyridine to mice, hamsters, rats, guinea-pigs, rabbits and ferrets, resulted in the urinary excretion of their N-oxides. Pyridine-N-oxide was found to be a quantitatively important metabolite of pyridine in all the species studied; the percentage of the dose excreted in the urine as pyridine-N-oxide ranged from 10% in rats to about 40% in mice and guinea-pigs. 3-Chloropyridine-N-oxide and 3-methylpyridine-N-oxide accounted for less than 7% of the administered dose of the parent base. The urinary excretion of pyridine-N-oxide was considerably greater in mice pretreated with phenobarbitone, compared to control mice, whereas 3-methylchloranthrene pretreatment had no appreciable effect on the excretion of pyridine-N-oxide.
D000818:Animals; D006224:Cricetinae; D004032:Diet; D005289:Ferrets; D006168:Guinea Pigs; D008297:Male; D008647:Mesocricetus; D051379:Mice; D010084:Oxidation-Reduction; D011725:Pyridines / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013997:Time Factors
D011725:Pyridines