Comparative automated assay of anti-P1 antibodies in acute hepatic distomiasis (fascioliasis) and in hydatidosis.
An automated assay of anti-P1 allohemagglutinins has been carried out on 133 P2 subjects: 13 with acute hepatic distomiasis (Fascioliasis), 20 with hydatidosis and 100 healthy blood donors. Anti-P1 were detected in 100% of the distomatid sera, in 50% of the hydatid and in 29% of the healthy individuals. When compared to a reference serum test (anti-P1 standard), their concentration was found to be weak in healthy subjects, moderate in hydatidosis and exceptionally increased in acute distomiasis (up to 5-6 times the standard anti-P1 level). The 2-mercaptoethanol treatment showed that even the increased distomatid anti-P1 sera were of an IgM nature. The respective origin, synthesis and strength of these allohemagglutinins are discussed and the advantages of using distomatid IgM anti-P1 as human sera test are emphasized.
D001322:Autoanalysis; D001789:Blood Group Antigens; D004443:Echinococcosis / Q000097:blood / Q000276:immunology*; D005211:Fascioliasis / Q000097:blood / Q000276:immunology*; D006801:Humans; D007518:Isoantibodies / Q000276:immunology*; D010127:P Blood-Group System; D010641:Phenotype
D001789:Blood Group Antigens; D007518:Isoantibodies; D010127:P Blood-Group System