Contact allergy to idoxuridine. Sensitization following treatment of herpes zoster.
A total of 45 of 60 patients with herpes zoster previously treated with topical idoxuridine 5-40% in dimethylsulfoxide were patch tested 2 years later with idoxuridine 0.5% and 5% in petrolatum. Three (7%) showed positive reactions. Idoxuridine is considered a weak sensitizer, but in strong concentrations and in active solvents, which increases absorption, there seems to be a risk of sensitization.
D000293:Adolescent; D000328:Adult; D000368:Aged; D003877:Dermatitis, Contact / Q000209:etiology*; D005260:Female; D006562:Herpes Zoster / Q000188:drug therapy*; D006801:Humans; D007065:Idoxuridine / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged
D007065:Idoxuridine