[The participation of the adrenal catecholamine system of tumor-bearing rats in sarcolysin-mediated effect].
In rats with transplantable Walker carcinosarcoma the injection of sarcolysin is found to retard a fall in the adrenaline concentration in adrenal tissues, observed without the substance. Normalization of the adrenaline level proceeds against the background of variations in the noradrenaline concentration near and above control values. Injecting of sarcolysin in intact animals results in normalization of the adrenaline level against the background of a considerable fall in the noradrenaline concentration after each injection of the drug. Changes of the same character were also observed in case of injecting saline solution in intact animals, the only difference being due to the fact that the effect of sarcolysin is dependent on animals age, while that of saline solution is not.
D000311:Adrenal Glands / Q000378:metabolism*; D000367:Age Factors; D000818:Animals; D002279:Carcinoma 256, Walker / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism*; D008297:Male; D008558:Melphalan / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology
D012965:Sodium Chloride; D008558:Melphalan; D009638:Norepinephrine; D004837:Epinephrine
Ob uchasti sistemy katekholaminov nadpochechnikov krys-opukholenositeleĭ v oposredovannom deĭstvii sarkolizina.