The antiandrogenic effect of progesterone on the hamster flank organ.
Progesterone, topically applied, prevents the stimulation of the hamster flank organ by testosterone, but not by dihydrotestosterone. 5 alpha-Dihydroprogesterone does not prevent stimulation by either of the two androgenic hormones. Neither progesterone nor 5 alpha-dihydroprogesterone stimulate the flank organ to any extent. Implications on the use of progesterone in acne therapy are discussed.
D004092:20-alpha-Dihydroprogesterone / Q000494:pharmacology; D000818:Animals; D006224:Cricetinae; D013196:Dihydrotestosterone / Q000494:pharmacology; D005260:Female; D008297:Male; D008647:Mesocricetus; D011374:Progesterone / Q000494:pharmacology*; D012627:Sebaceous Glands / Q000187:drug effects*; D013739:Testosterone / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D013196:Dihydrotestosterone; D004092:20-alpha-Dihydroprogesterone; D013739:Testosterone; D011374:Progesterone