Increased glutathione-S-transferase activity in antioxidant-deficient rats.
Rats fed a diet deficient in vitamin E and selenium show an increased activity of glutathione-S-transferase (EC 2.5.1.18) in all tissues tested, with the possible exception of the retina. Glutathione-S-transferases are detoxifying enzymes that are induced by a variety of electrophilic drugs or toxins. Therefore, the induction of glutathione-S-transferase in vitamine E- and selenium-deficient rats indicates that substrates for the enzyme probably increase in vivo with dietary antioxidant deficiency. These substrates are likely to be lipid peroxides and/or other lipid peroxidation products.
D000818:Animals; D001921:Brain / Q000201:enzymology; D004790:Enzyme Induction; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D008297:Male; D051381:Rats; D012160:Retina / Q000201:enzymology; D012643:Selenium / Q000172:deficiency; D013737:Testis / Q000201:enzymology; D014811:Vitamin E Deficiency / Q000201:enzymology*
D005982:Glutathione Transferase; D012643:Selenium