Influence of parathyroid hormone and calcitonin on tissue zinc homeostasis in the rat.
Tissue zinc accumulation kinetics and compartmental analysis models were evaluated in thyroparathyroidectomized (TPTX) rats treated with parathyroid extract or calcitonin. The animals were injected with 65Zn and studied at multiple time intervals. SAAM-25 was utilized to generate models from the plasma specific activity decay curves. Calcitonin had a marked effect to decrease the fractional influx and efflux transfer coefficients in the model and inhibit tissue zinc accumulation in several, but not all, tissues. Parathyroid extract increased accumulation in all tissues studied, but had minimal effects on the model. It is concluded that parathyroid hormone acts nonspecifically and that calcitonin appears to have specific influences on zinc homeostasis.
D000818:Animals; D002116:Calcitonin / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D006706:Homeostasis / Q000187:drug effects*; D007700:Kinetics; D008297:Male; D010281:Parathyroid Hormone / Q000494:pharmacology*; D051381:Rats; D014018:Tissue Distribution; D015032:Zinc / Q000097:blood / Q000378:metabolism*
D010281:Parathyroid Hormone; D002116:Calcitonin; D015032:Zinc; D002118:Calcium