Relative bioavailability of a paracetamol suppository.
The relative bioavailability of a new paracetamol suppository (Panodil) and tablets in doses of 0.5 and 1 g was investigated in eight healthy subjects. The tablets were absorbed faster and higher peak plasma concentrations were obtained than after the suppositories. The bioavailability of the suppositories was approximately 80% of that of the tablets at both dose levels. There was no indication of capacity-limited elimination at either the two doses investigated.
D000082:Acetaminophen / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D000328:Adult; D001682:Biological Availability; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D013488:Suppositories; D013607:Tablets
D013488:Suppositories; D013607:Tablets; D000082:Acetaminophen