title: Regulation of bacitracin synthetase by divalent metal ions in Bacillus licheniformis.
abstract: The activity in vitro of the bacitracin synthetase of Bacillus licheniformis ATCC 10716 is influenced by divalent metal ions (Mg2+, Mn2+, Fe2+ or Co2+) and by bacitracin. It is possible that complexes between bacitracin and metal ions exert feedback control on the synthetase. An overall control mechanism for bacitracin synthetase may consist of substrate-metal ion complexes and product-metal ion complexes.
mesh_terms: D000596:Amino Acids / Q000378:metabolism; D001407:Bacillus / Q000201:enzymology*; D001414:Bacitracin / Q000494:pharmacology; D003035:Cobalt / Q000494:pharmacology; D004789:Enzyme Activation / Q000187:drug effects; D005246:Feedback; D007501:Iron / Q000494:pharmacology; D008274:Magnesium / Q000494:pharmacology; D008345:Manganese / Q000494:pharmacology; D008670:Metals / Q000494:pharmacology*; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010453:Peptide Synthases / Q000037:antagonists & inhibitors / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D008670:Metals; D009097:Multienzyme Complexes; D001414:Bacitracin; D003035:Cobalt; D008345:Manganese; D007501:Iron; D010453:Peptide Synthases; C019761:bacitracin synthetase; D008274:Magnesium