Structure-function relationship in euthyroid goiter (an electronmicroscopical study.
The authors studied the structure-function relationship at the ultrastructural level in euthyroid goiter. Following results were found: small and short microvilli at the apical cell surface: irregular, elongated cisternae of rough endoplasmic reticulum and lysosomes of varying size, sometimes associated with globules or colloid droplets in form of phagolysosomes; irregular, swollen mitochondria, sometimes with a central empty area or an electron-dense amorphous core. The authors concluded that the euthyroid goiter is characterized by a slightly impaired hormone synthesis in the rough endoplasmic reticulum, a damaged mechanism of hormone transport within the cell and respiratory disturbances of the thyreocyte.
D000328:Adult; D005260:Female; D006042:Goiter / Q000473:pathology*; D006801:Humans; D008854:Microscopy, Electron; D008875:Middle Aged; D013961:Thyroid Gland / Q000648:ultrastructure*