Effect of sodium bicarbonate on in vitro conversion of fibrinogen to fibrin.
The effect of sodium bicarbonate on the conversion of fibrinogen to fibrin clot was investigated using fresh human whole blood and pure human fibrinogen. In vitro experimental data demonstrated that sodium bicarbonate interfered with fibrin clot formation during clotting. This study assessed the possibility of synergistic action of sodium bicarbonate with dosium citrate. As expected, sodium citrate potentiated the anticoagulant action of sodium bicarbonate.
D000925:Anticoagulants; D001639:Bicarbonates / Q000494:pharmacology*; D001711:Biotransformation; D002951:Citrates / Q000494:pharmacology; D004357:Drug Synergism; D005337:Fibrin / Q000378:metabolism*; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011517:Prothrombin Time; D013918:Thrombin Time
D000925:Anticoagulants; D001639:Bicarbonates; D002951:Citrates; D005337:Fibrin; D005340:Fibrinogen