Effects of postmenopausal ethinylestradiol treatment on gallbladder bile.
Bile composition was studied in three postmenopausal women without evidence of gallstone disease during administration of 50 micrograms of ethinylestradiol daily. The treatment resulted in an increased fraction of cholesterol in gallbladder bile and a shift in the bile acid composition with decreased relative concentration of chenodeoxycholate and increased fraction of cholate. These changes in bile lipid composition might explain the higher incidence of gallstones in women treated with estrogens.
D001647:Bile Acids and Salts / Q000032:analysis; D002769:Cholelithiasis / Q000139:chemically induced*; D002784:Cholesterol / Q000032:analysis; D004997:Ethinyl Estradiol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008593:Menopause; D008875:Middle Aged
D001647:Bile Acids and Salts; D004997:Ethinyl Estradiol; D002784:Cholesterol