[Morphological studies of leukocyte long-term culture. 1. A new in vitro phenomenon in the diagnosis of discoid lupus erythematosus].
A new routine-method is presented for the morphokinetic documentation of autoimmunologically induced processes in vitro via leukocyte long-term culture (LLC). The prominent rosette-sheeped autologous lymphocytes in deposition at central granulocytes are well defined. These autologous rosette-formations in LLC rank very high in diagnosis of autoimmundiseases, since this phenomenon is positive already, while the results of current methods in routine-serumexaminations are still negative. Presenting a case of discoid Lupus Erythematodes this well developed method is represented in early recognition of dermatological autoimmundiseases, while cellular cinetics are discussed.
D000328:Adult; D003470:Culture Media; D005260:Female; D006801:Humans; D007962:Leukocytes / Q000378:metabolism / Q000648:ultrastructure*; D008179:Lupus Erythematosus, Discoid / Q000175:diagnosis* / Q000473:pathology; D008214:Lymphocytes / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D012397:Rosette Formation
D003470:Culture Media
Morphologische Untersuchungen in der Leukozyten-Langzeitkultur. 1. Ein neues in vitro-Phänomen zur Diagnostik des discoiden Lupus Erythematoides.