title: Diagnosis of splenic involvement in Hodgkin's disease by radionuclide evaluation of splenic contraction in response to adrenaline.
abstract: Splenic contraction in response to adrenaline was studied by a radionuclidic technique in 33 patients who then underwent exploratory laparotomy and splenectomy. The decrease in splenic size was estimated by the percent diminution of spleen area from the baseline scan, and was found to be significantly less (p less than 0.001) in the group of patients with Hodgkin's involvement of the spleen. Possible applications of the test for diagnostic purposes are discussed.
mesh_terms: D000328:Adult; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006689:Hodgkin Disease / Q000000981:diagnostic imaging*; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009367:Neoplasm Staging / Q000379:methods*; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000473:pathology; D013156:Splenectomy
chemical_list: D004837:Epinephrine