Effect of normovolemic hemodilution of skeletal muscle oxygen pressure fields in atherosclerotic mini-pigs. Preliminary report.
Normovolemic hemodilution with dextran-70 was carried out in 4 Göttingen mini-pigs with induced atherosclerosis. Hematocrit was lowered stepwise to 10--15%. Measurements of the skeletal muscle surface oxygen pressure fields were carried out using the MDO oxygen electrode. Results indicated an optimal PO2 histogram at hematocrit between 21 and 25%, with uniformly abnormal histograms at hematocrit 10%. Cardiac output determinations in 1 animal revealed an initial increase in stroke volume (Hct 29%) followed by increasing heart rate at lower hematocrits. The results indicate that normovolemic hemodilution can be tolerated even in the presence of experimental atherosclerosis and that the matter needs further clinical study.
D000818:Animals; D002302:Cardiac Output; D003327:Coronary Disease / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D006400:Hematocrit; D006438:Hemodilution; D009132:Muscles / Q000378:metabolism*; D010100:Oxygen / Q000097:blood / Q000378:metabolism*; D013318:Stroke Volume; D013552:Swine
D010100:Oxygen