The effect of riboflavin on red-cell vitamin B6 metabolism and globin synthesis.
Red-cell conversion rate of pyridoxine to pyridoxal phosphate, and globin synthesis were measured before and after oral riboflavin in a patient with heterozygous beta-thalasaemia in 3 separate trials. In this patient a very slow B6 conversion rate increased to normal on each occasion after riboflavin, and there was a marked increase in synthesis of alpha and beta globin chains but no change in beta/alpha ratio. This was confirmed in a similar patient after a single trial of oral riboflavin. In 5 control subjects after a single trial of riboflavin the red-cell pyridoxine conversion rate increased whether the initial rate was fast or slow, and there was a considerable increase in globin synthesis in 3 of these.
D000284:Administration, Oral; D004912:Erythrocytes / Q000378:metabolism*; D005914:Globins / Q000096:biosynthesis*; D006801:Humans; D007700:Kinetics; D011736:Pyridoxine / Q000378:metabolism*; D012256:Riboflavin / Q000008:administration & dosage / Q000494:pharmacology*; D013789:Thalassemia / Q000378:metabolism*
D005914:Globins; D011736:Pyridoxine; D012256:Riboflavin