Effects of 6-chloro-6-deoxyglucose on electrolyte and water transport in the epididymis and fertility of male rats.
The effects of 6-chloro-6-deoxyglucose (6 CDG) on the transport of electrolytes and water in the cauda epididymidis and fertility of male rats were studied. Injection of 6 CDG into male rats at a dose rate of 120 muM/kg/day for 7-14 days induced sterility and inhibited sodium and water reabsorption in the perfused cauda epididymidis by about 60%. The rates of potassium and protein secretion were unaffected. When these rats were allowed to recover for 10 weeks, both fertility and the Na and water reabsorption of the cauda were restored. It is proposed that the chlorinated sugar may affect epididymal sperm metabolism through an effect on the transport function of the epididymis.
D000818:Animals; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004822:Epididymis / Q000187:drug effects*; D005298:Fertility / Q000187:drug effects*; D008297:Male; D011188:Potassium / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012964:Sodium / Q000378:metabolism; D014867:Water / Q000378:metabolism
D003837:Deoxy Sugars; D011506:Proteins; D014867:Water; D003847:Deoxyglucose; D012964:Sodium; D011188:Potassium