Clearance of technetium 99m-labeled sulfur colloid particles from the blood in normal dogs and in dogs with hepatic granulomata.
The clearance of technetium 99m-labeled sulfur colloid particles from the blood was studied in a series of seven clinically normal dogs. The effect of recent (6 hours) injections of bacteria bacillus Calmette-Guerin or Corynebacterium parvum markedly impeded the clearance of the colloid from the blood, due to a partial blockade effect. This phenomenon was reversible. When multiple experimentally induced hepatic granulomatous lesions were present, the clearance was similarly impeded. In contrast, however, this was not a reversible event. The possible application of this technique to diagnosis was discussed.
D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage; D003102:Colloids; D003352:Corynebacterium; D004283:Dog Diseases / Q000097:blood* / Q000503:physiopathology; D004285:Dogs / Q000097:blood*; D006099:Granuloma / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D008099:Liver / Q000503:physiopathology; D008107:Liver Diseases / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D010587:Phagocytosis; D013455:Sulfur; D013667:Technetium
D001500:BCG Vaccine; D003102:Colloids; D013455:Sulfur; D013667:Technetium