title: [Problems of treatment with thyroid hormones. Thyroxin monotherapy or a T3/T4 combination preparation?].
abstract: At the instance of T3- and T4-measurements of the daily profile in the serum after the application of triiodothyronine and the usual T3/T4-combination preparations is referred to the unphysiologically high T3-peaks 2 to 4 hours after the application depending on the proportion of triiodothyronine. The three distributed all over the day doses of e.g. thyreotom do not sufficiently smooth such undulations. The lacking triiodothyronine serum peaks after application of pure thyroxin as a bolus confirm the demand of a thyroxin monotherapy. Nevertheless, for answering the question of the "physiologic thyroid hormone therapy" some problems remain open which are discussed. Taking into consideration these facts (particularly conversation and extrathyroid influence of the thyroid hormone metabolism) a combination of T3 to T4 in the ratio 1:10 is recommended.
mesh_terms: D000328:Adult; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006042:Goiter / Q000188:drug therapy; D006801:Humans; D008297:Male; D013963:Thyroid Hormones / Q000008:administration & dosage* / Q000627:therapeutic use; D013974:Thyroxine / Q000008:administration & dosage* / Q000097:blood; D014284:Triiodothyronine / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
chemical_list: D013963:Thyroid Hormones; D014284:Triiodothyronine; D013974:Thyroxine
vernacular_title: Probleme bei der Behandlung mit Schilddrüsenhormonen. Thyroxin-Monotherapie oder T3/T4-Kombinationspräparate?