title: Normal human endometrium in cell culture. III. Mechanism(s) of epithelial polyploidization.
abstract: Autoradiography has confirmed previous cytophotometric results showing epithelial polyploid formation to be dependent on DNA synthesis. Polyploidization appears to be largely caused by endoreduplication and perhaps, to a lesser extent, by failure of cytokinesis.
mesh_terms: D000328:Adult; D000782:Aneuploidy; D001345:Autoradiography; D002467:Cell Nucleus / Q000378:metabolism; D002478:Cells, Cultured / Q000166:cytology; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication; D004717:Endometrium / Q000166:cytology*; D004847:Epithelial Cells; D005260:Female; D006801:Humans; D008938:Mitosis; D011123:Polyploidy
chemical_list: D004247:DNA