title: The renal clearance of thyroid hormones in the isolated perfused rat kidney.
abstract: The isolated perfused rat kidney was used to study renal handling of thyroid hormones. Substrate enriched protein free perfusates were chosen which allowed the kidneys to perform a normal glomerular filtration rate of 1.1 ml/g kidney x min and enabled accurate estimation of filtered load and tubular handling of free thyroid hormones without interference from the presence of hormone binding substances. Under these conditions we found a high tubular reabsorption capacity for both T3 and T4. This reabsorption capacity was unsaturable, even when the filtered hormone load was far above (x 100) the physiological range.
mesh_terms: D000042:Absorption; D000818:Animals; D007668:Kidney / Q000378:metabolism*; D007678:Kidney Glomerulus / Q000378:metabolism; D007684:Kidney Tubules / Q000378:metabolism; D007700:Kinetics; D008297:Male; D010477:Perfusion; D051381:Rats; D013974:Thyroxine / Q000378:metabolism*; D014284:Triiodothyronine / Q000378:metabolism*
chemical_list: D014284:Triiodothyronine; D013974:Thyroxine