title: Malfunction of a Björk-Shiley mitral valve prosthesis due to excessive platelet-fibrin deposition on its sewing cuff. A case report.
abstract: A Bjork-Shiley mitral valve prosthesis had to be replaced 4 years after implantation because of disc entrapment by an over-grown fibrous tissue on its sewing cuff. This abnormal fibrous tissue was found out to be an organizing platelet-fibrin deposit, of which luminal surface was only incompletely endothelialized. It is indicated that the heart valve prosthesis generally remains non-endothelialized for a prolonged period of time after implantation in man. Anticoagulation therapy should thus be given throughout the postoperative period for patients with the heart valve prosthesis.
mesh_terms: D000328:Adult; D001792:Blood Platelets / Q000473:pathology; D004727:Endothelium / Q000502:physiology; D005260:Female; D005337:Fibrin / Q000032:analysis; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006801:Humans; D008943:Mitral Valve / Q000473:pathology / Q000601:surgery*; D011183:Postoperative Complications; D013927:Thrombosis / Q000209:etiology* / Q000473:pathology
chemical_list: D005337:Fibrin