Maintenance control of oral anticoagulant therapy by a chromogenic substrate assay for factor X.
An amidolytic assay employing the chromogenic substrate S 2337 (Kabi Diagnostica) was used to assay factor X in 35 healthy controls and in 100 outpatients receiving oral anticoagulant therapy. This method correlated well with a coagulation assay of factor X in the control group (r = 0.88). When compared with two routine tests for the control of anticoagulant theray (Thrombotest and prothrombin ratio) good correlation was obtained between the methods, r = 0.84 and r = -0.74 respectively. These results suggest that a chromogenic substrate assay for factor X might be a suitable method for the maintenance control of oral anticoagulant therapy.
D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000627:therapeutic use*; D001780:Blood Coagulation Tests; D004151:Dipeptides; D005170:Factor X / Q000032:analysis*; D006801:Humans; D008875:Middle Aged; D011516:Prothrombin / Q000032:analysis; D011933:Reagent Kits, Diagnostic
D000925:Anticoagulants; D004151:Dipeptides; D011933:Reagent Kits, Diagnostic; C021129:S 2238; D011516:Prothrombin; D005170:Factor X