[Growth inhibition by phenylalanine and tyrosine--metabolism of phenylalanine in Flavobacterium devorans (author's transl)].
Growth of a chloramphenicol-resistant mutant of Flavobacterium devorans (F. devorans r) was inhibited by L-phenylalanine and L-tyrosine and furthermore by L-tryptophan, 4-amino-benzoate, anthranilate and homogentisate. The inhibitionwas reversed partially by simultaneous addition of aromatic amino acids and 4-amino-benzoate. After cultivating F. devorans r in a glucose-minimal medium containing L-phenylalanine, the metabolites L-tyrosine, 4-hydroxyphenylpyruvate, 4-hydroxyphenylacetate, 4-hydroxybenzaldehyd, 4-hydroxybenzoate, homogentisate and anthranilate were found. Growth inhibition and a hypothetical degrading pathway of phenylalanine are discussed.
D062365:Aminobenzoates / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005417:Flavobacterium / Q000187:drug effects* / Q000254:growth & development / Q000378:metabolism; D010649:Phenylalanine / Q000378:metabolism* / Q000494:pharmacology*; D014364:Tryptophan / Q000494:pharmacology; D014443:Tyrosine / Q000494:pharmacology*; D062367:ortho-Aminobenzoates / Q000494:pharmacology
D062365:Aminobenzoates; D062367:ortho-Aminobenzoates; D014443:Tyrosine; D010649:Phenylalanine; D014364:Tryptophan
Wachstumshemmung durch Phenylalanin und Tyrosin--Metabolisierung von Phenylalanin in Flavobacterium devorans.