title: Puberty in Laron type dwarfism.
abstract: The onset and progress of puberty was followed in 18 patients (7 males and 11 females) with Laron-type dwarfism (LTD). The boys had delayed puberty, testicular enlargement occurring between 12--14 years being the first sign. The first conscious ejaculation occurred between 17--21 years and full maturity was reached after the age of 22. In girls menarche occurred between 13--14 years and full maturity was reached between 16-19 years. Two patients--one male and one female--have children.
mesh_terms: D000293:Adolescent; D000328:Adult; D004393:Dwarfism, Pituitary / Q000503:physiopathology*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D008297:Male; D008572:Menarche; D011627:Puberty; D012737:Sex Factors; D013997:Time Factors
chemical_list: D013006:Growth Hormone