Tolazamide-induced cholestasis.
The sulfonylurea hypoglycemic agent tolazamide is thought to be a rare cause of jaundice and to exhibit no hepatic cross-sensitivity with other sulfonylurea compounds. We have described a patient who had self-limited cholestatic jaundice after treatment with chlorpropamide. Subsequent treatment with tolazamide resulted in recurrence of jaundice, which disappeared after cessation of treatment. Tolazamide may exhibit hepatic cross-sensitivity with chlorpropamide.
D002747:Chlorpropamide / Q000009:adverse effects; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008875:Middle Aged; D014042:Tolazamide / Q000009:adverse effects*
D014042:Tolazamide; D002747:Chlorpropamide