Serum 25-hydroxycholecalciferol in Greek uremics.
Using a simplified competitive protein-binding assay, we measured serum 25-hydroxycholecalciferol (25-OH-D3) in 52 patients with chronic renal failure and in 21 normal subjects. Of the patients with chronic renal failure, 21 were undergoing hemodialysis. Low serum levels of 25-OH-D3 were found in nondialysis patients and normal levels in the dialysis group. A positive relationship between the levels of 25-OH-D3 and serum calcium and a negative relationship between the levels of 25-OH-D3 and serum creatinine were found in the nondialysis group. We postulate that the decreased 25-OH-D3 levels in chronic uremics is the result of the low level of vitamin D in their protein-restricted diets.
D000328:Adult; D000368:Aged; D005260:Female; D006115:Greece; D006801:Humans; D006887:Hydroxycholecalciferols / Q000097:blood*; D007676:Kidney Failure, Chronic / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014511:Uremia / Q000097:blood* / Q000178:diet therapy; D014808:Vitamin D Deficiency / Q000209:etiology
D006887:Hydroxycholecalciferols