Reversal by naloxone of hemorrhagic shock in anephric cats.
Hemorrhage, 15 ml/kg induced a rapid fall of blood pressure in intact and anephric cats, but only intact cats demonstrated significant blood pressure recovery following bleeding. Naloxone, 0.1 mg/kg x min, i.v., had a mild promoting effect on blood pressure recovery in the intact cats whereas, in the hemorrhaged anephric cats naloxone re-established an almost complete recovery of blood pressure. These results suggest that endogenous opioid substances play a significant depressor role in hemorrhagic shock, especially in anephric animals.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002415:Cats; D004723:Endorphins / Q000502:physiology; D005260:Female; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D009392:Nephrectomy; D012771:Shock, Hemorrhagic / Q000188:drug therapy / Q000503:physiopathology*
D004723:Endorphins; D009270:Naloxone