Electrophoresis of serum proteins from a homogeneous population in Brittany: the  Bigoudens.
Serum from 408 subjects drawn at random from a population of 29,985 was tested by quantitative electrophoresis and, when a narrow band was detected, by immunoelectrophoresis. Six cases of monoclonal gammapathy (MG) were found, including four with IgMK and two with IgGK. The incidence of MG (1.47%) was not particularly high, but the proportion of IgM (66.67%) was abnormally elevated. This peculiarity does not seem due to the advanced age of the subjects tested (58 +/- 13 years) but might be the result of too much inbreeding until recent years.
D000328:Adult; D000368:Aged; D001797:Blood Protein Electrophoresis; D004588:Electrophoresis, Cellulose Acetate; D005260:Female; D005602:France; D006801:Humans; D006942:Hypergammaglobulinemia / Q000453:epidemiology*; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G / Q000032:analysis*; D007075:Immunoglobulin M / Q000032:analysis*; D008297:Male; D008875:Middle Aged
D007074:Immunoglobulin G; D007075:Immunoglobulin M