Blockade of audiogenic seizures by bromocryptine.
In 21-day-old DBA/2H mice, bromocryptine (5 mgKg-1) induces great reduction of total and lethal audiogenic seizures. This effect increases with time during the first hour after injection. In mice pretreated with spiroperidol (0.5 mgKg-1), bromocryptine fails to produce this protective effect. These results suggest that dopaminergic pathways may be involved in inhibition of audiogenic seizures.
D000161:Acoustic Stimulation; D000818:Animals; D000927:Anticonvulsants; D001971:Bromocriptine / Q000494:pharmacology*; D051379:Mice; D008811:Mice, Inbred DBA; D011954:Receptors, Dopamine / Q000187:drug effects
D000927:Anticonvulsants; D011954:Receptors, Dopamine; D001971:Bromocriptine