[Hemolytic autoimmune anemia caused by (+)-cyanidanol-3 (Catergen)].
Several episodes of acute intravascular immune hemolysis in a 68 year old patient induced by (+)-cyanidanol-3 (Catergan) are reported. Clinical and serological criteria of the so-called immune-complex mechanism of immune drug-induced hemolysis were realised. The meaning of the additional marked affinity of the drug to the erythrocytic surface remains unclear. The patient's serum was cross-reactive with rutine but not with troxerutine.
D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000139:chemically induced*; D001578:Benzopyrans / Q000009:adverse effects*; D002392:Catechin / Q000009:adverse effects* / Q000378:metabolism; D003429:Cross Reactions; D004910:Erythrocyte Membrane / Q000378:metabolism; D006801:Humans; D008297:Male; D011955:Receptors, Drug; D012431:Rutin / Q000378:metabolism
D001578:Benzopyrans; D011955:Receptors, Drug; D012431:Rutin; D002392:Catechin
Durch (+)-Cyanidanol-3 (Catergen) induzierte immunhämolytische Anämie.