Change in permeability of liposomal membranes mediated by C-reactive protein and its inhibition by cholesterol.
CRP-positive human serum specifically releases the trapped glucose from multilamellar liposomes composed of egg lecithin and dicetylphosphate. The release is dependent on Ca++ ion and is suppressed by incorporation of cholesterol into liposomes membranes. A specific role of cholesterol in CRP-receptor recognition at membranes of immunocytes is suggested.
D002097:C-Reactive Protein / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D002784:Cholesterol / Q000494:pharmacology*; D005947:Glucose / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D008081:Liposomes / Q000378:metabolism*
D008081:Liposomes; D002097:C-Reactive Protein; D002784:Cholesterol; D005947:Glucose; D002118:Calcium