Changes in gastric mucosal morphology, capillary permeability and blood flow during the first 3 days of acute gastritis in cats.
In the present investigation gastric morphology, blood flow, vascular permeability and water content were studied in cat stomachs with acetic acid-induced gastritis at different time intervals up to 3 days after induction of gastritis. The morphological changes including mucosal erosions, edema and hemorrhage showed normalization within 3 days. The mucosa and muscularis blood flow remained essentially unchanged compared with pre-gastritis values and with the control group. Gastritis was associated with leakage of circulating albumin into the stomach wall most pronounced 4 h after the induction of gastritis. The water content was high at 4 and 24 h after induction of gastritis with almost normalization at 3 days. The morphologaical characteristics of our model are very similar to those observed in man. Leakage of circulating albumin into the gastric wall seems to be the best parameter for quantifaication of the inflammatory changes found in acute gastritis, while blood flow seems to be a less important parameter.
D000208:Acute Disease; D000818:Animals; D002199:Capillary Permeability; D002415:Cats; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply* / Q000473:pathology; D005756:Gastritis / Q000378:metabolism / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D012039:Regional Blood Flow; D012711:Serum Albumin, Radio-Iodinated / Q000378:metabolism; D013270:Stomach / Q000032:analysis; D014867:Water / Q000032:analysis
D012711:Serum Albumin, Radio-Iodinated; D014867:Water