Effects of n-alkanols on the membrane fluidity of chick embryo heart microsomes.
The n-alkanols from butanol through octanol are membrane perturbing agents that fluidize the microsomal membranes of 20-day-old chick embryo hearts as measured by the fluorescence depolarization of 1,6-diphenylhexatriene. In terms of the aqueous concentrations of n-alkanols the fluidizing effect increases with increasing number of carbons per n-alkanol. In terms of the membrane concentrations of n-alkanols the fluidizing effect is roughly equivalent for all the n-alkanols studied.
D000438:Alcohols / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D007425:Intracellular Membranes / Q000187:drug effects / Q000378:metabolism*; D008560:Membrane Fluidity / Q000187:drug effects*; D008861:Microsomes / Q000378:metabolism*; D009206:Myocardium / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014783:Viscosity
D000438:Alcohols