Does use of oral contraceptives enhance the toxicity of carbon disulfide through interactions with pyridoxine and tryptophan metabolism?
It is proposed that oral contraceptive (OC) users are at increased risk to experiencing adverse psychological disorders (e.g. irritability, depression) from exposures to elevated levels of carbon disulfide (CS2). This theory is based on studies indicating that both OCs and CS2 induce either a vitamin B6 deficiency and/or enhance its requirement. Since disruptions of B6 metabolism are thought to explain, at least in part, the adverse psychological effects of OCs and CS2, it is speculated that joint exposure to these substances may result in an exaggerated disruption of B6 metabolism with the development of CS2 induced adverse psychological effects occurring at exposure levels below those normally associated with adverse effects.
D002246:Carbon Disulfide / Q000633:toxicity*; D003276:Contraceptives, Oral / Q000009:adverse effects*; D004357:Drug Synergism; D004781:Environmental Exposure; D005260:Female; D006801:Humans; D008956:Models, Chemical; D011736:Pyridoxine / Q000378:metabolism*; D014364:Tryptophan / Q000378:metabolism*; D026681:Vitamin B 6 Deficiency / Q000139:chemically induced
D003276:Contraceptives, Oral; D014364:Tryptophan; D011736:Pyridoxine; D002246:Carbon Disulfide