[Does the calcium antagonist verapamil protect from myocardial damage during tocolysis with beta-sympathicomimetics? (author's transl)].
Under general anaesthesia nine mongrel dogs were first injected with fenoteral 0.06 mg/kg/per minute and later with fenoteral 0.06 mg/kg/per minute and verapamil 2 mg/kg/per minute. A microtip manometer was placed into the left ventricle and cardiac pressures continously monitored. The resulting pressure curves were used in micro-computer to calculate the cardiac pressure parameters including the inotropic measurements and the myocardical oxygen consumption. The intravenous infusion of the beta-mimetic fenoterol resulted in marked increase of the cardiac rate and contractility as measured in the different measurement of the ionotrophy. A corresponding increase of the myocardical oxygen consumption was found. The addition of the calcium antagonist verapamil did have no influence of the measured parameters. A protective effect of the calcium antagonist on the myocaridium was excluded in the animal experiment. A protective effect during tocolysis with beta-sympathicomimetics cannot be expected because of the expected low serum concentrations.
D000818:Animals; D009202:Cardiomyopathies / Q000139:chemically induced / Q000517:prevention & control*; D004285:Dogs; D005260:Female; D005280:Fenoterol / Q000009:adverse effects; D006339:Heart Rate; D009200:Myocardial Contraction; D007752:Obstetric Labor, Premature / Q000517:prevention & control; D010101:Oxygen Consumption; D011247:Pregnancy; D014700:Verapamil / Q000627:therapeutic use*
D005280:Fenoterol; D014700:Verapamil
Bietet der Kalziumantagonist Verapamil bei der Tokolyse mit Beta-Sympathikomimetika den erwarteten Schutz vor Myokardschäden?