title: Hypothyroidism induced by anti-epileptic therapy.
abstract: Two patients on long-term anti-epileptic treatment, one with both phenytoin and carbamazepine, the other with carbamazepine, developed clinical hypothyroidism. Laboratory assays verified the diagnosis. Both patients became euthyroid and the thyroid hormone assays were normal after withdrawal of the drugs.
mesh_terms: D000368:Aged; D002220:Carbamazepine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000139:chemically induced*; D008875:Middle Aged; D010672:Phenytoin / Q000009:adverse effects*
chemical_list: D002220:Carbamazepine; D010672:Phenytoin