Structure-activity relationships for potent phthalane and thiophthalane inhibitors of norepinephrine uptake. A comparison with desipramine and related compounds.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001572:Benzofurans / Q000494:pharmacology*; D003891:Desipramine / Q000031:analogs & derivatives / Q000494:pharmacology*; D007031:Hypothalamus / Q000378:metabolism; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009638:Norepinephrine / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013564:Sympathetic Nervous System / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism; D013876:Thiophenes / Q000494:pharmacology*
D000928:Antidepressive Agents; D001572:Benzofurans; D013876:Thiophenes; C004302:phthalapromine; C001750:talsupram; D003891:Desipramine; D009638:Norepinephrine