Chemotherapy of neuroblastoma in mice with anticancer agents.
Neuroblastoma-inoculated A/J mice were treated with various anticancer chemotherapeutic agents, including cyclophosphamide, daunorubicin, vincristine, alpha-bungarotoxin, dihydroxytryptamine, and diaminopropane. Cyclophosphamide and diaminopropane inhibited neuroblastoma as effectively as bromoacetylcholine and bromacetate. The effectiveness of these drugs could be related to the inhibition of ornithine decarboxylase, a rate-limiting enzyme for the synthesis of polyamines.
D015115:5,6-Dihydroxytryptamine / Q000627:therapeutic use; D000085:Acetates / Q000627:therapeutic use; D000109:Acetylcholine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000627:therapeutic use; D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002038:Bungarotoxins / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000494:pharmacology / Q000627:therapeutic use; D003630:Daunorubicin / Q000627:therapeutic use; D003959:Diamines / Q000627:therapeutic use; D008297:Male; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009447:Neuroblastoma / Q000188:drug therapy*; D065108:Ornithine Decarboxylase Inhibitors; D014750:Vincristine / Q000494:pharmacology / Q000627:therapeutic use
D000085:Acetates; D000970:Antineoplastic Agents; D002038:Bungarotoxins; D003959:Diamines; D065108:Ornithine Decarboxylase Inhibitors; D014750:Vincristine; C016274:bromoacetate; D003520:Cyclophosphamide; C009475:trimethylenediamine; D000109:Acetylcholine; D015115:5,6-Dihydroxytryptamine; D003630:Daunorubicin