The influence of inhibition of prostaglandin synthesis on hippurate extraction in conscious, newborn lambs.
The influence of indomethacin (INDO) on the renal extraction of hippurate (EH) was studied in 12 conscious, newborn lambs divided into two groups based upon age. EH was measured before and after INDO (7.5 mg/kg i.v.) by collecting blood samples from both the abdominal aorta (opposite the renal artery) and renal vein (under fluoroscopy). In the youngest group (0--4 days, n = 5), control EH was 18 +/- 8% (mean +/- SE) and increased to 29 +/- 6% following INDO (p = NS). In the older animals (2--3 weeks, n = 7) control EH was 66 +/- 5% (p less than 0.001), compared to the 0--4-day-olds) and decreased to 57 +/- 4% following INDO (p less than 0.02). The results suggest that EH increases during the first weeks of life and that prostaglandins may play a role in regulating the tubular transport of hippurate.
D000818:Animals; D000831:Animals, Newborn; D006626:Hippurates / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology*; D007668:Kidney / Q000187:drug effects / Q000502:physiology; D011453:Prostaglandins / Q000096:biosynthesis*; D012756:Sheep
D006626:Hippurates; D011453:Prostaglandins; D007213:Indomethacin