Herbicolins--New peptide antibiotics from Erwinia herbicola.
Erwinia herbicols (strain A 111) produces two acylated peptide antibiotics herbicolins A and B. Isolation of herbicolins was performed by adsorption on a polystryrol adsorbent followed by elution with methanol. Further purification was achieved by gel filtration on Sephadex LH-20, counter-current distribution or by TLC. Herbicolin A was chemically characterized, containing 2 glycines, 1 L-threonine, 1 D-allo-threonine, 1 D-glutamic acid, 1 D-leucine, 1 L-agrinine and beta-hydroxy myristic acid. Herbicolins A and B are inactive against bacteria, but highly active against yeasts and filamentous fungi.
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D023181:Antimicrobial Cationic Peptides; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D002627:Chemistry, Physical; D004352:Drug Resistance, Microbial; D004885:Erwinia / Q000032:analysis*; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D009842:Oligopeptides; D010455:Peptides / Q000302:isolation & purification / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D023181:Antimicrobial Cationic Peptides; D009842:Oligopeptides; D010455:Peptides; C027099:herbicolin A; C064202:herbicolin B