Aminoalkanesulfonic acids IV:Synthesis of mitodepressive N-nitrosoaminoalkanesulfonic acids.
Sodium aminoalkanesulfonates were synthesized from substituted amines and aldehyde sodium bisulfites at 40-60 degrees. Nitrosation yielded the corresponding N-nitroso derivatives. Mitodepressive activity on cresse (Lepidium sativum L.) was determined, and all compounds examined possessed growth inhibition activity. The N-nitroso derivatives were slightly less active but also showed less toxicity than the parent aminoalkanesulfonic acids.
D055598:Chemical Phenomena; D002621:Chemistry; D003864:Depression, Chemical; D008938:Mitosis / Q000187:drug effects*; D012639:Seeds; D013451:Sulfonic Acids / Q000138:chemical synthesis* / Q000494:pharmacology
D013451:Sulfonic Acids