title: Prelymphomatous and lymphomatous changes in splenomegaly of new zealand black mice.
abstract: The incidence of splenomegaly was 39.6% in the nontreated group and 41.0% in the treated group, not significantly different between both groups. Thymic lymphoma group shared 27.6%, while the nonthymic lymphoma group 67.9%, significantly different between both. Histological findings of splenomegaly of the nonlymphoma groups were divided into the following 5 types. 1) follicular form, 2) periarterial lymphatic sheath form, 3) red pulp hematopoietic form, 4) marginal zone form, and 5) red pulp reticulosis form. Histology of the spleen in the lymphoma group resembled each form of cases of splenomegaly in the nonlymphoma group. Lymphoma based upon immune abnormality and specific to this kind of mouse in nonthymic lymphoma continuously takes place from prelymphomatous changes in the nonlymphoma group. Splenic origin and role of mariginal zone of nonthymic lymphoma in murine lymphoma is discussed.
mesh_terms: D000818:Animals; D002369:Castration; D004967:Estrogens; D005260:Female; D008223:Lymphoma / Q000139:chemically induced / Q000662:veterinary*; D008297:Male; D051379:Mice; D008814:Mice, Inbred NZB; D011379:Prognosis; D012376:Rodent Diseases / Q000473:pathology*; D013154:Spleen / Q000473:pathology*; D013163:Splenomegaly / Q000150:complications* / Q000473:pathology; D014520:Urethane
chemical_list: D004967:Estrogens; D014520:Urethane