Chromosomal analysis in bone-marrow cells of Chinese hamsters after treatment with mycotoxins.
Mycotoxins are ubiquitously occurring metabolites of moulds that grow on foodstuffs. They are able to cause toxic diseases in man and animals. Aflatoxin B1 (AFB1), aflatoxin G1 (AFG1) and platulin (PA) induce chromosomal damage in Chinese hamster bone-marrow cells. With respect to the number of induced aberrant mitoses the 3 mycotoxins can be ranked in the order PA greater than AFB1 greater than AFG1.
D000284:Administration, Oral; D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D006224:Cricetinae / Q000235:genetics*; D003412:Cricetulus / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009153:Mutagens; D009183:Mycotoxins / Q000008:administration & dosage; D010365:Patulin / Q000494:pharmacology*; D011714:Pyrans / Q000494:pharmacology*
D000348:Aflatoxins; D009153:Mutagens; D009183:Mycotoxins; D011714:Pyrans; D010365:Patulin