title: Antibodies to denatured bovine collagens in sera of patients with liver disease.
abstract: Sera from 101 patients with liver disease were studied for the presence of antibodies to three types of denatured bovine collagens by passive haemagglutination assay. A high incidence and titres were found especially in chronic active hepatitis, liver cirrhosis and primary hepatoma. The incidence and titres of antibodies to Type I and Type III collagens were significantly higher than those of antibodies to Type II collagen. Analysis by gel filtration on Sephadex G-200 or absorption with anti-IgG and IgM antisera revealed that the antibodies belonged to both IgG and IgM classes. They correlated with serum gamma-globulin levels, but not with rheumatoid factor.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D000906:Antibodies / Q000032:analysis*; D000918:Antibody Specificity; D002417:Cattle; D002648:Child; D003094:Collagen / Q000276:immunology*; D005260:Female; D006386:Hemagglutination Tests; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008107:Liver Diseases / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D011489:Protein Denaturation
chemical_list: D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D003094:Collagen