title: Inhibition of histamine-sensitive adenylate cyclase from guinea pig fundic gastric mucosa by arachidonic acid and by an analog of prostaglandin endoperoxide PGH2.
abstract: The effects of prostaglandin precursors, namely an analog of prostaglandin endoperoxide PGH2 [(15S)-hydroxy-9 alpha,11 alpha-(epoxymethano)prosta-5,13-dienoic acid] and arachidonic acid, were assessed on gastric adenylate cyclase activity from cell-free preparations of guinea pig fundic mucosa. The two precursors were tested against basal adenylate cyclase activity and that simulated by histamine (10(-4) M), by PGE2(10(-4) M), by 5
mesh_terms: D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000201:enzymology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*; D044262:Prostaglandin H2; D011463:Prostaglandins H / Q000494:pharmacology
chemical_list: D000067956:Adenylyl Cyclase Inhibitors; D001095:Arachidonic Acids; D011450:Prostaglandin Endoperoxides, Synthetic; D011463:Prostaglandins H; D044262:Prostaglandin H2; D006632:Histamine; D000262:Adenylyl Cyclases; D007213:Indomethacin