Interaction of the absorbable hemostatic agent (IP760) with aminoglycosidic antibiotics.
The linear, crosslinked amylose-succinate hemostatic agent, IP760, has been evaluated for its interaction with aminoglycosidic antibiotics. The highly structured polymer appears to act as a cationic exchange resin which binds the basic aminoglycosides. Binding of these agents to IP760 is reversed by increased pH and/or increased ionic strength. Dialysis experiments demonstrated that 85 and 90% of the bound gentamicin was released at pH 7.5 and 8.0, respectively, over a period of 36 hr. Formation of the IP760-antibiotic complexes suggests potential medicinal use for hemostatis and slow release of the antibiotic for prophylaxis of postsurgical contamination or infection
D000042:Absorption; D000688:Amylose / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001665:Binding Sites; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004347:Drug Interactions; D005839:Gentamicins / Q000494:pharmacology*; D006490:Hemostatics / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007612:Kanamycin / Q000494:pharmacology; D009355:Neomycin / Q000494:pharmacology; D009994:Osmolar Concentration; D011108:Polymers / Q000494:pharmacology*; D013386:Succinates / Q000494:pharmacology*
D005839:Gentamicins; D006490:Hemostatics; D011108:Polymers; D013386:Succinates; C026171:sodium amylose succinate; D007612:Kanamycin; D000688:Amylose; D009355:Neomycin