Indirect evidence for the importance of steady-state [K]o in determining the extent of the effects of hyperpolarizing electrogenesis on vascular smooth muscle reactivity.
Abruptly increasing [K]o and adding ouabain produce short-term depression and enhancement, respectively, of vascular smooth muscle (VSM) reactivity, presumably as a result of stimulating and inhibiting, respectively, hyperpolarizing electrogenesis. Moreover, the presence of a steady-state level of electrogenesis is implicated by the enhancing effect of ouabain. The results of this study indicate that the extent of these short-term changes in electrogenesis and the level of this steady-state electrogenesis are regulated by small changes in steady-state [K]o within a physiological range, 3--6 mM.
D000818:Animals; D001158:Arteries; D004558:Electric Stimulation; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D010042:Ouabain / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology / Q000502:physiology*; D011817:Rabbits; D012964:Sodium / Q000502:physiology; D013997:Time Factors
D010042:Ouabain; D012964:Sodium; D011188:Potassium