Inter-species comparisons of carcinogenicity.
The carcinogenicity of 250 chemicals in 2 species, usually the rat and the mouse, was obtained from the published literature through 3 independent sources. Of the 250 compounds listed, 38% were non-carcinogenic in both rats and mice, and 44% were carcinogenic in both species. A total of 43 compounds had different results in the two species, 21 (8%) being carcinogenic in mice only, 17 (7%) in rats only and 5 (2%) having differing results from other species. A comparison of the major target organs affected by chemicals carcinogenic in both species revealed that 64% of the chemicals studied produced cancer at the same site. This comparison of carcinogenic activity in 2 species suggests that extrapolation from results in a single-animal study to man may be subject to substantial errors.
D000818:Animals; D002273:Carcinogens / Q000633:toxicity*; D004353:Drug Evaluation, Preclinical; D051379:Mice; D009369:Neoplasms / Q000139:chemically induced*; D009928:Organ Specificity; D051381:Rats; D012107:Research Design; D013045:Species Specificity
D002273:Carcinogens