Augmentation of luteinizing hormone action by prostaglandin E2 in the prevention of antispermatogenic effect of indomethacin. Indomethacin & spermatogenesis.
Administration of indomethacin exhibited antigonadal action by inhibiting the Leydig cells, sex-accessories and spermatocyte-spermatid conversion process. Administration of PGE2 or PGF2 alpha had no effect on Leydig cell nuclear volume or accessory organ weights, but PGE2 had a restorative effect on the efficiency of meiosis, although at a statistical non-significant level. Administration of LH to indomethacin treated rats restored the accessories fully with a non-significant effect on the yield of step-7 spermatids from meiosis. Simultaneous administration of indomethacin, LH and PGE2 (but not PGF2 alpha) restored both sex-accessories and spermatid number to the level of vehicle injected controls.
D000818:Animals; D002467:Cell Nucleus / Q000187:drug effects; D007213:Indomethacin / Q000494:pharmacology*; D007985:Leydig Cells / Q000187:drug effects; D007986:Luteinizing Hormone / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology; D011467:Prostate / Q000187:drug effects; D051381:Rats; D012669:Seminal Vesicles / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects
D011458:Prostaglandins E; D011460:Prostaglandins F; D007986:Luteinizing Hormone; D007213:Indomethacin