Platelet uptake of 5-hydroxytryptamine and dopamine and its relationship to mood in normal subjects.
Platelet uptake of the amines 5-hydroxytryptamine (5-HT) and dopamine has been found to be lower in depressed than in normal subjects. In the latter the values were more scattered. To discover whether this scatter was due to mild depression or predisposition to depression, 50 normal subjects whose amine uptake had been studied were asked to complete a questionnaire on symptoms and history of depression. No significant correlation between decreased amine uptake and answers to the questionnaire was found, but a correlation of minor significance (r=0.33; P less than 0.025) was found between increased number of potentially depressing life events and increased 5-HT uptake, contrary to what might have been expected. The scatter of values for amine uptake does not appear to be related to mood, or to personal or family history of depression.
D001792:Blood Platelets / Q000378:metabolism*; D003863:Depression / Q000097:blood*; D004298:Dopamine / Q000097:blood*; D006801:Humans; D012701:Serotonin / Q000097:blood*
D012701:Serotonin; D004298:Dopamine