The effect of cismethrin on the rat dorsal root potentials.
Dorsal root potentials were recorded from urethane-anaesthetised rats. Bicuculline, a recognised GABA antagonist, reduced the amplitude of the potential to 67% of control. Cismethrin, a synthetic pyrethroid insecticide, enhanced the potential to 142% of control values. The convulsions associated with cismethrin poisoning therefore are not produced by an antagonism of GABA-mediated inhibitory transmission.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001640:Bicuculline / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D007306:Insecticides / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects; D011722:Pyrethrins / Q000494:pharmacology*; D051381:Rats; D013126:Spinal Nerve Roots / Q000187:drug effects*
D007306:Insecticides; D011722:Pyrethrins; C017498:cismethrin; D001640:Bicuculline