The effects of cyclophosphamide, nitrosomethylurea and benzo(a)pyrene on the rat incisor.
Wistar rats given a single intraperitoneal injection of 75 mg cyclophosphamide revealed dental anomalies in the form of shortening or lengthening of incisors, and development of supernumerary teeth. Rats given additionally 5 mg/kg b. w. of a nitrosomethylurea solution over a period of four months showed the same dental anomalies, but with relatively shorter latency times. In a supplementary investigation examining the effects of benzo(a)pyrene and nitrosomethylurea applied locally to the organon dentale, neoplastic lesions and dental dysplasia were seen.
D000818:Animals; D001580:Benzopyrenes / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000009:adverse effects*; D007180:Incisor / Q000187:drug effects*; D008770:Methylnitrosourea / Q000009:adverse effects*; D009607:Nitrosourea Compounds / Q000009:adverse effects*; D009808:Odontogenic Tumors / Q000139:chemically induced; D051381:Rats; D014071:Tooth Abnormalities / Q000139:chemically induced*; D014083:Tooth Germ / Q000473:pathology; D014096:Tooth, Supernumerary / Q000139:chemically induced
D001580:Benzopyrenes; D009607:Nitrosourea Compounds; D008770:Methylnitrosourea; D003520:Cyclophosphamide