[Absorption and distribution of benzyloxyamine-containing aerosols (author's transl)].
The study of the blood levels and tissue concentrations in mice to which 14C-benzyloxyamine hydrochloride was applied in the form of a spray and of a suspensoid aerosol evidenced the good abosrption of this pharmacon. Maximum blood levels were observed 0.5 hour after administration of the spray. When the aerosol was given, the blood levels increased progressively and reached maximum values at the end of the experiment, 4 hours after application. The concentrations found in the lung, stomach, kidney and liver were, in general, higher on suspensoid aerosol application (maximum values being reached after 1--2 hours) than on spray administration.
D000042:Absorption; D000336:Aerosols; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage* / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism; D006898:Hydroxylamines / Q000008:administration & dosage* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D051379:Mice; D014018:Tissue Distribution
D000336:Aerosols; D000893:Anti-Inflammatory Agents; D006898:Hydroxylamines; C017064:benzyloxyamine
Resorption und Verteilung Benzyloxyamin enthaltender Aerosole.