Capillary gas chromatographic studies of cholesterol biosynthesis in rats treated with EGYT-1299.
Cholesterol and desmosterol concentrations were assayed by high-performance capillary gas chromatography. It was established that no toxic desmosterol accumulation occurred either in the serum or liver of rats receiving EGYT-1299 treatment. Desmosterol accumulation induced by triparanol was reduced by the agent at doses ten times lower than Atromid S; consequently its cholesterol lowering effect may be attributed to interference with cholesterol biosynthesis.
D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D002849:Chromatography, Gas / Q000379:methods*; D002994:Clofibrate / Q000031:analogs & derivatives* / Q000494:pharmacology; D003897:Desmosterol / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D014308:Triparanol / Q000494:pharmacology*; D014508:Urea / Q000031:analogs & derivatives* / Q000494:pharmacology
D003897:Desmosterol; D014308:Triparanol; D014508:Urea; D002784:Cholesterol; D002994:Clofibrate; C025095:urefibrate