[Mechanisms of neuro-tropic disorders induced in skeletal muscles by botulinum toxin].
The relationship between activation of cell nucleus division and disturbances of electrogenesis of skeletal muscle fibers which had been paralyzed by botulinum toxin was studied in experiments on rats. On the 5th day after its intramuscular injection botulinum toxin evoked depolarization of muscle fibers and appearance of local responses in addition to break action potentials (AP) in most of the fibers. Inhibition of DNA synthesis by daily intraperitomeal injection of fluorouracil prevented the decreasing of rest membrane potentials and appearance of anode break AP.
D000818:Animals; D001906:Botulism / Q000378:metabolism / Q000503:physiopathology*; D004247:DNA / Q000096:biosynthesis*; D005472:Fluorouracil; D008297:Male; D008564:Membrane Potentials; D009132:Muscles / Q000378:metabolism*; D009469:Neuromuscular Junction / Q000503:physiopathology*; D051381:Rats
D004247:DNA; D005472:Fluorouracil
O mekhanizmakh neĭrotroficheskikh narusheniĭ, vyzyvaemykh botulinicheskim toksinom v skeletnykh myshtsakh.