Teratogenic potential of phencyclidine in the mouse.
Pregnant CD-1 mice were given phencyclidine by gavage on days 6-15 of gestation, at dose levels of 60, 80, 100, and 120 mg/kg/day. The mice were killed on day 18 and the offspring were examined for external, visceral, and skeletal alterations. There was a significant increase in the average percent of malformed fetuses per litter only at the 120 mg/kg/day dose level (6.1% versus 1.2% for the control), a dose level which resulted in the death of 8 of 18 dams before scheduled sacrifice. At dose levels less than 120 mg/kg/day, the incidence of malformations was not significantly higher than the control value, in spite of the presence of overt maternal toxicity. Because a significant number of malformations was not seen at dose levels which were not highly toxic to the dams, it was concluded that phencyclidine was not demonstrated to be a teratogen in the mouse.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D051379:Mice; D010622:Phencyclidine / Q000494:pharmacology* / Q000633:toxicity; D011247:Pregnancy; D013723:Teratogens
D013723:Teratogens; D010622:Phencyclidine