Mechanism of virucidal activity of retinoids: protein removal from bacteriophage phi 6 envelope.
The mechanism of the potent virucidal activity of retinol (vitamin A) and retinal (vitamin A aldehyde) was investigated for the interaction of these compounds with a model system enveloped virus, bacteriophage phi 6. The retinoids bind to and inactivate phi 6 without causing large-scale disruption of the virion. Inactivated virions have completely lost the ability to adsorb to host bacteria due to the loss of a viral envelope protein necessary for adsorption.
D000998:Antiviral Agents / Q000494:pharmacology*; D001435:Bacteriophages / Q000187:drug effects*; D004591:Electrophoresis, Polyacrylamide Gel; D012172:Retinaldehyde / Q000494:pharmacology*; D014764:Viral Proteins / Q000032:analysis / Q000378:metabolism*; D014801:Vitamin A / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000998:Antiviral Agents; D014764:Viral Proteins; D014801:Vitamin A; D012172:Retinaldehyde