Antimicrobial activity of N-substituted N-(triphenylstannyl)cyanamides and triethylammonium (organocyanoamino)chlorotriphenylstannates.
N-Substituted N-(triphenylstannyl)cyanamides were studied and found to be better antifungal agents than the previously tested N-substituted N'-cyano-S-(triphenylstannyl)isothioureas and N-substituted N'-cyano-O-(triphenylstannyl)isoureas. They were similar in activity to the previously tested ethyl N-aryl-S-(triphenylstannyl)-isothiocarbamates. The antifungal activity of triethylammonium (organocyanoamino)chlorotriphenylstannates, which are the triethylammonium chloride complexes of N-substituted N-(triphenylstannyl)-cyanamides, was similar to or better than that of the N-substituted N-(triphenylstannyl)cyanamides. Triethylammonium (acetylcyanoamino)chlorotriphenylstannate and triethylammonium dichlorotriphenylstannate were highly inhibitory toward Gram-positive bacteria.
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001419:Bacteria / Q000187:drug effects; D009947:Organotin Compounds / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D009947:Organotin Compounds