Specific quantitation of urinary 6-hydroxymelatonin sulphate by gas chromatography mass spectrometry.
6-Hydroxymelatonin sulphate, a unique urinary metabolite of melatonin, has been measured in human subjects for the first time using a chromatography mass spectrometry and an isotope labelled internal standard. Urinary levels in both males and females were similar and ranged from 25-125 nmol 24 h-1. A significant nocturnal elevations of 6-hydroxymelatonin sulphate was also established in a male subject.
D003903:Deuterium; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008297:Male; D008550:Melatonin / Q000031:analogs & derivatives* / Q000652:urine
D003903:Deuterium; D008550:Melatonin; C012365:6-hydroxymelatonin