GAp junctions in skin tumors of molluscum contagiosum.
Thin section, tracer, and freeze-fracture experiments demonstrate that the infection caused by molluscum contagiosum virus implies alterations of cellular contacts in the epidermis, never before observed in cutaneous viroses. These changes are basically represented by a distinctive variation in particle packing of gap junctions, a greater proliferation of these junctions and the presence of a high amount of intracytoplasmic gap junctions. Skin tumors caused by molluscum contagiosum virus appear to be a convenient model to study the morphological and topological variations as well as the turnover of gap junctions in the epidermis.
D005614:Freeze Fracturing; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure; D008976:Molluscum Contagiosum / Q000473:pathology*; D012867:Skin / Q000648:ultrastructure*