title: The effects of several barbiturates on lithium chloride induced taste aversion.
abstract: The effects of single doses of five barbiturates on LiCl induced saccharin aversion were examined. Twenty three hour fluid deprived rats were offered a novel 0.125% saccharin solution and then were injected with either 3.0 mEq/kg LiCl or 0.9% saline. On the first test day after conditioning the animals were injected with either 60 mg/kg sodium phenobarbital, 80 mg/kg sodium barbital, 30 mg/kg sodium amobarbital, 20 mg/kg sodium secobarbital, 9 mg/kg sodium pentobarbital or 0.9% saline, 15 min prior to the drinking session. Results indicate that only 9 mg/kg pentobarbital, 60 mg/kg phenobarbital, and 80 mg/kg barbital were effective in attenuating the LiCl induced saccharin aversion on the day of administration. In addition, dipsogenic effects for only 60 mg/kg phenobarbital and 30 mg/kg amobarbital were observed in the saline treated control groups. A synergistic interaction between the effects of LiCl and sodium phenobarbital, barbital, and secobarbital was also observed. Lithium chloride plus these barbiturates resulted in a longer term aversion to saccharin than LiCl alone and no barbiturate produced saccharin aversion when administered without LiCl.
mesh_terms: D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001463:Barbiturates / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects; D004347:Drug Interactions; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D051381:Rats; D012439:Saccharin; D013649:Taste / Q000187:drug effects*
chemical_list: D001463:Barbiturates; D008094:Lithium; D012439:Saccharin