Epidermal carcinogenesis in young and aging animals.
1) There is an enhanced susceptibility to carcinogen in senescent mouse skin which we believe should cause deliberations about safety regulations for humans; 2) both accumulation of variant cell and/or change in a local mitosis regulatory system should serve as working hypothesis for further studies.
D000375:Aging; D000818:Animals; D006801:Humans; D051379:Mice; D008938:Mitosis; D012867:Skin / Q000166:cytology; D012878:Skin Neoplasms / Q000209:etiology*; D014020:Tissue Extracts / Q000494:pharmacology
D014020:Tissue Extracts