Induction of hepatocellular carcinoma in rat liver by initial treatment with benzo(a)pyrene after partial hepatectomy and promotion by phenobarbital.
The hepatocarcinogenicity of benzo(a)pyrene(BP) in the rat was examined. Rats were treaated with BP after partial hepatectomy and then kept on a diet containing phenobarbital (PB) as a promoter. Tumors including a hepatocellular carcinoma developed in the rat liver by week 52.
D000818:Animals; D001580:Benzopyrenes / Q000633:toxicity*; D006498:Hepatectomy; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
D001580:Benzopyrenes; D010634:Phenobarbital