[Effect of nitrite on the nutritional state of germ-free weaning rats (author's transl)].
For 14 days 2 groups of 10 young male Wistar rats in the germ-free state were fed on a chow ration, and to drink they were given either de-ionized water or a solution of sodium nitrite, 0.3 g per litre. At the end of the experiment thiamine, riboflavin, vitamin B6, niacin, biotin and pantothenic acid were estimated in various tissues (liver, kidneys, encephalon, heart, spleen, testes and muscle); nitrogen and phosphorus were estimated in the liver only. There was no difference between the groups in changes in body weight or fluid intake. But in the animals given sodium nitrite the liver weight was higher and there was an increase in kidney riboflavin content (+41 p. 100), and a decrease in heart riboflavin and vitamin B6 contents (-17 p. 100 and -10 p. 100, respectively) and liver pantothenic concentration (-26 p. 100). These results are different from those obtained with older S.P.F. rats [5], but are partially the same as those obtained with young S.P.F. rats [4].
D000818:Animals; D001710:Biotin / Q000378:metabolism; D005856:Germ-Free Life / Q000187:drug effects*; D008297:Male; D009539:Nicotinic Acids / Q000378:metabolism; D009573:Nitrites / Q000494:pharmacology*; D009928:Organ Specificity; D010205:Pantothenic Acid / Q000378:metabolism; D011736:Pyridoxine / Q000378:metabolism; D051381:Rats; D012256:Riboflavin / Q000378:metabolism; D012977:Sodium Nitrite / Q000494:pharmacology*; D013831:Thiamine / Q000378:metabolism; D014018:Tissue Distribution; D014803:Vitamin B Complex / Q000378:metabolism*
D009539:Nicotinic Acids; D009573:Nitrites; D014803:Vitamin B Complex; D010205:Pantothenic Acid; D001710:Biotin; D011736:Pyridoxine; D012977:Sodium Nitrite; D012256:Riboflavin; D013831:Thiamine
Effet du nitrite sur l'état de nutrition vitaminique B du rat axénique sevré.