Myocardial imaging in dogs with thallium-201 and the ionophore grisorixin.
The effect of grisorixin, a monocarboxylic ionophore, upon the myocardium-to-background ratio in thallium-201 scintigrams has been studied in 20 dogs. Three sequences of injection and two doses of the ionophore have been used. A significant improvement was obtained when grisorixin was injected 10 min before thallium-201 and at a submaximal dose; the myocardium-to-background ratio was at least twice that of the controls during the first 20 min following the tracer injection.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004285:Dogs; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging* / Q000187:drug effects; D007089:Image Enhancement; D007275:Injections, Intravenous; D007476:Ionophores; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism; D009550:Nigericin / Q000031:analogs & derivatives / Q000494:pharmacology*; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013793:Thallium; D013997:Time Factors
D000900:Anti-Bacterial Agents; D007476:Ionophores; D011868:Radioisotopes; C010731:grisorixin; D013793:Thallium; D009550:Nigericin