Protective cellular antigen of Clostridium chauvoei.
Cellular antigens of Clostridium chauvoei, strain IRP-128, were demonstrated to be important in induction of immunity against this bacterium in guinea pigs. At least one major component of the cellular antigen complex was heat-labile. Acid extraction of the bacterial cells, followed by selective purification for flagella, led to the preparation of an acid extract antigen that possessed a high degree of immunogenicity. The acid extract antigen contained flagellar components and was resolved into two major and approximately five minor protein components by polyacrylamide-gel electrophoresis.
D000818:Animals; D000917:Antibody Formation; D000942:Antigens, Bacterial / Q000276:immunology* / Q000302:isolation & purification; D003013:Clostridium / Q000276:immunology*; D003015:Clostridium Infections / Q000517:prevention & control / Q000662:veterinary*; D004591:Electrophoresis, Polyacrylamide Gel; D005407:Flagella / Q000276:immunology; D006168:Guinea Pigs / Q000276:immunology
D000942:Antigens, Bacterial