title: Time and temperature dependence of disintegration and correlation between dissolution and disintegration rate constants.
abstract: Commercial prednisone tablets were subjected to dissolution tests by USP basket and paddle methods. It was found experimentally that disintegration adheres to an exponential decay law: ln(W/Wo) = -d(t-ti), where W is the nondisintegrated weight, d is a disintegration constant, t is time, and ti is a lag time. Dissolution has been reported to adhere to a similar law, where the dissolution constant K, follows a pseudo-Arrhenius relationship with changing temperature. Within a certain temperature range, this relationship also exists for the disintegration rate constant, d. A correlation exists in these tablets between K and d. The shaft length in the dissolution apparatus plays a part in the disintegration (and hence dissolution) rate and, therefore, is an important apparatus parameter affecting reproducibility.
mesh_terms: D002626:Chemistry, Pharmaceutical / Q000295:instrumentation; D007700:Kinetics; D011241:Prednisone / Q000008:administration & dosage; D012995:Solubility; D013607:Tablets; D013696:Temperature; D013997:Time Factors
chemical_list: D013607:Tablets; D011241:Prednisone