Daunorubicin, daunorubicinol and DNA plasma kinetics after I.V. administration of daunorubicin-DNA complex in the rabbit. II. -- Effects of R. E. S.-blockade.
Reticuloendothelial system-blockade induced by collodial carbon in rabbits produced only a single modification of the plasma kinetics of daunorubicin-DNA complex, consisting in a significant prolongation of the distribution phase of the vector (DNA). No changes in distribution and metabolism of the cytostatic drug (DNR) were observed. Thus, a lysosomotropic mechanism does not play a major role in the disposition of DNA-complexed DNR.
D000818:Animals; D002244:Carbon / Q000494:pharmacology; D003630:Daunorubicin / Q000097:blood*; D003864:Depression, Chemical; D004705:Endocytosis / Q000187:drug effects; D007700:Kinetics; D012157:Mononuclear Phagocyte System / Q000276:immunology*; D011817:Rabbits
D002244:Carbon; D003630:Daunorubicin