Effect of hemorrhagic hypotension and hypoventilation on lower esophageal sphincter pressure.
Dysfunction of the lower esophageal sphincter has been demonstrated in the cat shock model. Analogies have been drawn to reflux and aspiration in the critically ill patient. In a cat shock model, lower esophageal sphincter pressure is reduced and response to bethanechol is impaired. Upon resuscitation to basal state with heparinized shed blood, the lower esophageal basal pressure returns to normal values, and response to bethanechol is restored. This model may explain reflux and aspiration in the critically ill patient.
D000138:Acidosis / Q000503:physiopathology; D000818:Animals; D001626:Bethanechol Compounds / Q000627:therapeutic use; D001815:Bloodletting; D002415:Cats; D004195:Disease Models, Animal; D004943:Esophagogastric Junction / Q000503:physiopathology*; D005764:Gastroesophageal Reflux / Q000209:etiology*; D006863:Hydrogen-Ion Concentration; D006935:Hypercapnia / Q000503:physiopathology; D007022:Hypotension / Q000188:drug therapy / Q000503:physiopathology*; D007040:Hypoventilation / Q000188:drug therapy / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology
D001626:Bethanechol Compounds