Species variation in the metabolism of 1-naphthylacetylglycylglycylglycine.
1-Naphthylacetylglycylglycylglycine was metabolized in rat and rabbit to mainly 1-naphthylacetylglucuronide; in toad to 1-naphthylacetic acid and 1-naphtylacetylglycine, and in lizard and tortoise to 1-naphthylacetic acid and its glycine and ornithine conjugates. In the in vitro studies, varying amounts of 1-naphthylacetic acid, its glycine and glycylglycine conjugates and some of the unchanged compound were detected in all the species.
D000818:Animals; D001001:Anura; D001711:Biotransformation; D008116:Lizards; D009842:Oligopeptides / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D014426:Turtles
D009842:Oligopeptides; C026387:1-naphthylacetylglycyl-glycyl-glycine