Cinepazet relaxation of aortic strips from normal and spontaneously hypertensive rats.
The vasodilator cinepazet (Vascoril) was tested for its ability to relax potassium-contracted aortic strips obtained from normal and spontaneously hypertensive rats (SHR). Cinepazet caused a dose-dependent relaxation of the isolated aortic strip preparations which had been contracted with 60 mM KCl. The ED50 for this relaxant effect was 200 microgram/ml. No differences in relaxation response to cinepazet were found between tissues from SHR and normal animals. The drug is 2 x 10(4) less potent than verapamil on a weight basis in this action on rat aortic tissue. The results suggest that the excitation-contraction mechanism associated with KCl-induced membrane depolarization is equally affected by cinepazet in aortae from SHR and WKY.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D005260:Female; D006973:Hypertension / Q000503:physiopathology*; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology*; D014700:Verapamil / Q000494:pharmacology
D010879:Piperazines; D014665:Vasodilator Agents; C020997:cinepazet; D011189:Potassium Chloride; D014700:Verapamil