Glutathione-dependent dehydroascorbate reduction: a determinant of dehydroascorbate uptake by human polymorphonuclear leukocytes.
Dehydroascorbate uptake and reduction are impaired in normal human polymorphonuclear leukocytes (PMN) preincubated with N-ethylmaleimide, and in glutathione reductase-deficient cells. We conclude that human PMN dehydroascorbate reduction is glutathione-dependent, and that dehydroascorbate reduction appears to be a necessary condition for cellular dehydroascorbate uptake.
D001205:Ascorbic Acid / Q000031:analogs & derivatives*; D003683:Dehydroascorbic Acid / Q000378:metabolism*; D005978:Glutathione / Q000378:metabolism; D005980:Glutathione Reductase / Q000172:deficiency*; D006801:Humans; D009504:Neutrophils / Q000378:metabolism*; D010084:Oxidation-Reduction
D005980:Glutathione Reductase; D005978:Glutathione; D001205:Ascorbic Acid; D003683:Dehydroascorbic Acid