Immunopotentiation by pyrimethamine in the mouse.
Pyrimethamine, a 2,4-diaminopyrimidine useful in the treatment of malaria and toxoplasmosis, was found to enhance antibody and delayed-type hypersensitivity responses to sheep red cells in mice. The immunodepression of tumour-bearing mice was also reversed by pyrimethamine. This drug may prove useful as a general immunostimulant in clinical situations where the immune system has been compromised by cancer or other debilitating illnesses.
D000276:Adjuvants, Immunologic; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006968:Hypersensitivity, Delayed; D008297:Male; D008545:Melanoma / Q000276:immunology; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000276:immunology; D011739:Pyrimethamine / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D011739:Pyrimethamine