Mass spectrometric identification of DL-verapamil metabolites.
DL-verapamil [2,8-bis(3,4-dimethoxyphenyl)-6-methyl-2-isopropyl-6-azaoctanitrile; Isoptin] is metabolized in man by N-dealkylation -- mainly by cleavage of the N6-C7 bond -- and by demethylation of the methoxy groups. After oral administration, besides unchanged verapamil, 12 metabolites could  be isolated from urine and their structures were elucidated by (GC-) mass spectrometry.
D001711:Biotransformation; D003640:Dealkylation; D006801:Humans; D013058:Mass Spectrometry; D014700:Verapamil / Q000652:urine*
D014700:Verapamil