[The weights of genital organs in germfree and conventional ICR mice administered with hCG, estradiol benzoate, progesterone and testosterone propionate (author's transl)].
Female germfree (Gf) and conventional (Cv) ICR mice aged 21-25 days were administered with hCG (50IU/head/day for 2 days). Six hours after the last administration, uterine weights of Gf and Cv mice were 175.8 mg% and 238.7 mg% respectively, the difference between Gf and Cv animals was statistically significant (p less than 0.05). Ovariectomized Gf and Cv mice aged 80-150 days were successively administered with estradiol benzoate (0.02 mg/head/day for 5 days). Six hours after the last administration, uterine weights of Gf and Cv mice were 358.8 mg% and 462.7 mg% respectively, being statistically significant between Gf and Cv animals (p less than 0.01). After administration of estradiol benzoate (0.02 mg/head/day for 2 days), 1.0 mg/head/day of progesterone for 3 days were given ovariectomized Gf and Cv mice aged 80-150 days. Six hours after the last administration, uterus of Gf and Cv mice were weight 337.6 mg% and 423.5 mg% respectively, the difference was statistically significant (p less than 0.01). Castrated Gf and Cv mice aged 80-150 days were administered with 1.0 mg of testosterone propionate (head/day for 5 days). Six hours after the last administration, weights of seminal vesicle and coagulating gland of Gf and Cv mice were 376.0 mg% and 611.8 mg% respectively, the difference was statistically significant (p less than 0.01).
D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005835:Genitalia / Q000033:anatomy & histology* / Q000187:drug effects; D005856:Germ-Free Life; D012739:Gonadal Steroid Hormones / Q000494:pharmacology*; D006728:Hormones / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR / Q000033:anatomy & histology*; D009929:Organ Size / Q000187:drug effects; D011374:Progesterone / Q000494:pharmacology; D013739:Testosterone / Q000494:pharmacology
D012739:Gonadal Steroid Hormones; D006728:Hormones; D013739:Testosterone; D011374:Progesterone; D004958:Estradiol