Effects of 2-deoxy-D-glucose on multi-unit activity of the hypothalamus in rats.
Multi-unit activity was recorded from the diencephalon of unanesthetized, immobilized female rats. Less than 50% of the recording sites in the hypothalamus showed changes in the level of multi-unit activity to changes in the level of glucose utilization induced by injection of 2-deoxy-D-glucose (2-DG). It was also not possible to specificy an area within the hypothalamus in which there was a concentration of recording sites which consistently responded to 2-DG. Relatively large amplitude, long duration changes in multi-unit activity levels were also observed in the optic tract, suggesting that 2-DG induced a widespread cellular metabolic response to glucoprivation which may not have been related to the regulation of feeding.
D000818:Animals; D001931:Brain Mapping; D002415:Cats; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D004594:Electrophysiology; D005247:Feeding Behavior / Q000187:drug effects* / Q000502:physiology; D005260:Female; D007031:Hypothalamus / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D013045:Species Specificity
D003837:Deoxy Sugars; D003847:Deoxyglucose