Antagonistic effects of propranolol upon ethanol-induced narcosis in mice.
The interaction of dl-propranolol with narcosis induced by ethanol was studied in mice. dl-propranolol reduced significantly the duration of ethanol-induced narcosis. This antagonism was also present in animals pre-treated with pyrazole. The d-isomer of propranolol, devoid of beta-blocking action, did not decrease the duration of ethanol-induced narcosis. The blood levels of ethanol at the end of narcosis were similar in animals with or without dl-propranolol pre-treatment. These results support the hypothesis that this action of dl-propranolol could be mediated by central adrenergic beta receptors.
D000818:Animals; D000431:Ethanol / Q000037:antagonists & inhibitors* / Q000097:blood / Q000494:pharmacology; D005260:Female; D008297:Male; D051379:Mice; D011433:Propranolol / Q000494:pharmacology*; D011720:Pyrazoles / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*
D011720:Pyrazoles; D000431:Ethanol; D011433:Propranolol