Effects of phosphonium compounds on Schistosoma mansoni.
A new series of phosphonium salts was examined for effects on the cholinergic nervous system of Schistosoma mansoni. Studies were conducted using both an activity-monitoring and fluorescent-labeling technique. The activity method gave more definitive results, indicating that some poly(methylene)bis(triphenylphosphonium) salts and some [3-(alkylamino)propyl]triphenylphosphonium salts have strong anticholinergic effects. Hexyltriphenylphosphonium bromide has very marked effects both in the motility and the fluorescence test, but these effects cannot immediately be ascribed to cholinergic actions.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D003619:Dansyl Compounds; D008297:Male; D008856:Microscopy, Fluorescence; D009068:Movement / Q000187:drug effects; D009861:Onium Compounds / Q000138:chemical synthesis / Q000494:pharmacology; D011950:Receptors, Cholinergic / Q000187:drug effects; D012550:Schistosoma mansoni / Q000187:drug effects* / Q000378:metabolism
D003619:Dansyl Compounds; D009861:Onium Compounds; D011950:Receptors, Cholinergic; D000109:Acetylcholine