title: Analysis of growth dynamics and the relationship to the fluctuations in alkaline phosphatase in two strains of cells of HeLa S3 derivation.
abstract: Studies have been carried out to determine an association between glucocorticoid-induced changes in the pattern of growth and the fluctuations of alkaline phosphatase in two HeLa strains. The results showed that growth arrest in steroid-treated cells did not have the characteristics of density-induced growth inhibition. Alkaline phosphatase increased with increased cell density, the increase being greater than control in steroid-treated cells of the "inducible" strain (HeLa S3G, HeLa65) and less than control in the "suppressible" strain (HeLa S3K, HeLa71). Increased serum concentration in the growth medium (0 to 20%) caused an increase in alkaline phosphatase in S3G strain and a decrease in the S3K strain.
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D001769:Blood; D002452:Cell Count; D002455:Cell Division / Q000187:drug effects*; D003470:Culture Media; D003907:Dexamethasone / Q000494:pharmacology*; D004790:Enzyme Induction; D006367:HeLa Cells; D006801:Humans; D013696:Temperature
chemical_list: D003470:Culture Media; D003907:Dexamethasone; D000469:Alkaline Phosphatase