Evaluation of sensory irritation from some common industrial solvents.
An animal bioassay model was used to determine the potency of some common industrial solvents as sensory irritants. Acetone was found to be the least potent and ethyl acetate the most potent. A series of alcohols tested, from methanol to pentanol, revealed an increase in potency with the increasing number of carbons.
D000079:Acetaldehyde / Q000633:toxicity; D000085:Acetates / Q000633:toxicity; D000096:Acetone / Q000633:toxicity; D000438:Alcohols / Q000633:toxicity; D000818:Animals; D007509:Irritants; D008297:Male; D051379:Mice; D012119:Respiration / Q000187:drug effects; D011984:Sensory Receptor Cells / Q000187:drug effects*; D012997:Solvents / Q000633:toxicity*
D000085:Acetates; D000438:Alcohols; D007509:Irritants; D012997:Solvents; D000096:Acetone; D000079:Acetaldehyde