Inhibition of histamine-sensitive adenylate cyclase from guinea pig fundic gastric mucosa by arachidonic acid and by an analog of prostaglandin endoperoxide PGH2.
The effects of prostaglandin precursors, namely an analog of prostaglandin endoperoxide PGH2 [(15S)-hydroxy-9 alpha,11 alpha-(epoxymethano)prosta-5,13-dienoic acid] and arachidonic acid, were assessed on gastric adenylate cyclase activity from cell-free preparations of guinea pig fundic mucosa. The two precursors were tested against basal adenylate cyclase activity and that simulated by histamine (10(-4) M), by PGE2(10(-4) M), by 5
D000067956:Adenylyl Cyclase Inhibitors; D000262:Adenylyl Cyclases / Q000378:metabolism; D000818:Animals; D001095:Arachidonic Acids / Q000494:pharmacology*; D005750:Gastric Juice / Q000378:metabolism; D005753:Gastric Mucosa / Q000201:enzymology*; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D011450:Prostaglandin Endoperoxides, Synthetic / Q000494:pharmacology*; D044262:Prostaglandin H2; D011463:Prostaglandins H / Q000494:pharmacology
D000067956:Adenylyl Cyclase Inhibitors; D001095:Arachidonic Acids; D011450:Prostaglandin Endoperoxides, Synthetic; D011463:Prostaglandins H; D044262:Prostaglandin H2; D006632:Histamine; D000262:Adenylyl Cyclases; D007213:Indomethacin