Influence of flow amplitude on pulmonary resistance determined near zero flow.
Pulmonary resistance, determined near zero flow by means of the isovolume technique, increases with the total amplitude of flow. This variation observed in healthy subjects at two frequencies, and documented also by other investigators, was stimulated in a model study. The main factor responsible for the amplitude dependence of pulmonary or airway resistance appears to be the asymmetrical elastic characteristics of the airways.
D000328:Adult; D000403:Airway Resistance; D003201:Computers; D005260:Female; D006801:Humans; D008168:Lung / Q000502:physiology*; D008170:Lung Compliance; D008176:Lung Volume Measurements; D008297:Male; D008433:Mathematics; D008954:Models, Biological; D012119:Respiration