title: Influence of intracoronary meglumine diatrizoate on regional myocardial contractility and the protective effect of hydrocortisone.
abstract: The effects of direct intracoronary injection of meglumine diatrizoate (RENOGRAFIN) on regional myocardial contractility were studied in 11 open-chested dogs. The left anterior descending or circumflex artery was cannulated selectively from the ascending aorta and the changes in myocardial contractile force and its first derivative were measured by an epicardial strain gauge sutured to the myocardium supplied by the cannulated artery. The myocardium perfused by the non-cannulated artery served as the control area. Direct intracoronary injection of meglumine diatrizoate, 1 ml, caused regional depression of myocardial function, with a significant decrease in contractile force and its first derivative in the study area; there was no change in the control area, nor were there changes in the first derivative of left ventricular pressure, heart rate or systemic blood pressure. There was no additive depressant effect after multiple injections. Local pretreatment with hydrocortisone (4 mg/kg, by slow intracoronary infusion) ameliorated the myocardial depressant effect of meglumine diatrizoate so that there was a smaller decrease in contractile force and its first derivative. The results may have clinical significance in patients undergoing coronary arteriography.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003973:Diatrizoate / Q000031:analogs & derivatives*; D003974:Diatrizoate Meglumine / Q000037:antagonists & inhibitors*; D004285:Dogs; D004562:Electrocardiography; D006854:Hydrocortisone / Q000494:pharmacology*; D009200:Myocardial Contraction / Q000187:drug effects*; D013997:Time Factors
chemical_list: D003973:Diatrizoate; D003974:Diatrizoate Meglumine; D006854:Hydrocortisone