title: [Preoperative polychemotherapy in the overall treatment of locally spread breast cancer (immediate results)].
abstract: Eighty three patients with locally spread cancer of the mammary gland (stage IIIb and IIIc) were subjected to the preoperative polychemotherapy with 5-fluoruracil, methotrexate, cyclophosphane, vincristine against the background of the hormonal therapy (ovarioectomy + corticosteroids). Diminishing of the tumor bulk by 50% was noted in 53 patients. In 26 cases the effect was less pronounced, no effect was observed in 4. Side effects and complications occurred during chemotherapy (40 patients) were liquidated by selecting the individual doses of chemical drugs and the corresponding symptomatic therapy. Among 83 patients with a local spread of breast cancer the preoperative polychemotherapy enabled radical mastectomy to be performed in 79 of them.
mesh_terms: D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D003520:Cyclophosphamide / Q000008:administration & dosage; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage; D008875:Middle Aged; D009367:Neoplasm Staging; D011300:Preoperative Care / Q000379:methods*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D014750:Vincristine; D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate
vernacular_title: Predoperatsionnaia polikhimioterapiia v kompleksnom lechenii mestnorasprostranennogo raka molochnoĭ zhelezy (neposredstvennye rezul'taty).