A comparison of two different dosages of pivampicillin and doxycycline in patients with gynaecological infections.
The efficacy of 500 mg pivampicillin twice daily, 350 mg pivampicillin 3-times daily and 100 mg doxycycline daily was compared in 106 patients with salpingitis, parametritis or endometritis. Both the pivampicillin regimens were equally effective. The average duration of therapy needed to produce a satisfactory clinical response was shorter with pivampicillin (14 days) than with doxycycline (21 days). Pivampicillin improved the patients' gynaecological status in 90% of the subjects treated compared to only 70% of patients given doxycycline. Fewer relapses were recorded in women given pivampicillin (4%) than in subjects treated with doxycycline (15%). Gonococci were isolated from 10% of vaginal swabs. The involvement of Chlamydia and Mycoplasma was not studied. However, the high cure rate indicated that, if present, they did not pose a therapeutic problem. Side-effects, mainly dyspepsia, were observed in 2 patients in each group. The twice-daily administration of pivampicillin is recommended, since it is more practical and increases patient compliance.
D000328:Adult; D000667:Ampicillin / Q000031:analogs & derivatives*; D001424:Bacterial Infections / Q000188:drug therapy; D004305:Dose-Response Relationship, Drug; D004318:Doxycycline / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004716:Endometritis / Q000188:drug therapy*; D005260:Female; D006801:Humans; D010249:Parametritis / Q000188:drug therapy*; D010917:Pivampicillin / Q000627:therapeutic use*; D012488:Salpingitis / Q000188:drug therapy*
D010917:Pivampicillin; D000667:Ampicillin; D004318:Doxycycline