Increased gastrin release in chronic calcifying pancreatitis and in chronic alcoholism.
Plasma gastrin levels were measured by radioimmunoassay before and after a test meal associated with 40 ml ethanol in 21 patients presenting with chronic calcifying pancreatitis, in 10 apparently normal subjects drinking since at least 5 years 100 g alcohol a day, in 14 subjects presenting hepatic alcoholic cirrhosis and in 18 apparently normal non alcoholic controls. Post-stimulation gastrin concentration were higher in chronic pancreatitis patients or in normal alcoholics (peak post-stimulation value: 74 +/- 41 and 74 +/- 43 pg/ml respectively) than in cirrhotics or non alcoholic controls (45 +/- 26 and 41 +/- 15 pg/ml respectively) (m +/- SD).
D000328:Adult; D000437:Alcoholism / Q000378:metabolism*; D002908:Chronic Disease; D000431:Ethanol / Q000633:toxicity; D005215:Fasting; D005502:Food; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000097:blood; D008297:Male; D008875:Middle Aged; D010195:Pancreatitis / Q000378:metabolism*
D005755:Gastrins; D000431:Ethanol