Quinazoline antifolates with dual biochemical loci of action. Biochemical and biological studies directed towards overcoming methotrexate resistance.
D000818:Animals; D002470:Cell Survival / Q000187:drug effects; D005260:Female; D005492:Folic Acid / Q000378:metabolism; D005493:Folic Acid Antagonists; D007939:Leukemia L1210; D008727:Methotrexate / Q000378:metabolism / Q000494:pharmacology*; D051379:Mice; D011799:Quinazolines / Q000494:pharmacology* / Q000633:toxicity; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors
D005493:Folic Acid Antagonists; D011799:Quinazolines; C025927:CB 3703; C025928:CB 3705; D005492:Folic Acid; D013940:Thymidylate Synthase; D008727:Methotrexate