Intraventricular administration of isoproterenol inhibits both heat production and heat loss mechanisms in rats.
At an ambient temperature (Ta) of 8 degrees C, intraventricular administration of isoproterenol inhibited metabolic heat production and led to hypothermia in rats. In contrast, at a Ta of 22 degrees C and of 30 degrees C, isoproterenol decreased cutaneous circulation and led to hyperthermia. The data indicate that isoproterenol inhibits both heat production and heat loss mechanisms in rats.
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D006358:Hot Temperature; D007276:Injections, Intraventricular; D007545:Isoproterenol / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051381:Rats
D007545:Isoproterenol