The topical anti-inflammatory effects of piroxicam in rodents.
Piroxicam is a structurally novel, long-acting anti-inflammatory drug with potent activity following oral administration in animal models of inflammation and in human inflammatory diseases. The present studies, performed in rats, demostrate that topically applied piroxicam is a potent inhibitor of inflammation induced by either carrageenin or complete Freund's adjuvant. Comparable potencies (ED50 approximately 1--5 mg/kg) were obtained for topically and orally administered piroxicam in these models of inflammation. The potency of topical piroxicam exceeds that of topically applied bufexamac or phenylbutazone in the rat adjuvant arthritis model.
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000188:drug therapy; D001835:Body Weight / Q000187:drug effects; D002019:Bufexamac / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010653:Phenylbutazone / Q000494:pharmacology; D010894:Piroxicam; D011725:Pyridines / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D012869:Skin Absorption; D013843:Thiazines / Q000008:administration & dosage* / Q000378:metabolism / Q000494:pharmacology; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D011725:Pyridines; D013843:Thiazines; D010894:Piroxicam; D002019:Bufexamac; D010653:Phenylbutazone