[Relationship between the severity of the course of tetanus poisoning and the resistance level of the macroorganism].
In experiments on rats and rabbits with tetanus poisoning, activation of the nonspecific defence factors (humoral and cellular) was found in the early periods after administration of tetanus toxin. The growth of specific hemagglutinins was recorded later. The survival of the animals was prolonged and the titers of specific antibodies decreased in the course of administering the alpha-adrenoblocker butyroxan.
D000818:Animals; D003165:Complement System Proteins; D004146:Dioxanes / Q000627:therapeutic use; D007106:Immune Sera / Q000633:toxicity; D007962:Leukocytes / Q000276:immunology; D008198:Lymph Nodes / Q000166:cytology; D009113:Muramidase / Q000097:blood; D010587:Phagocytosis; D010950:Plasma Cells / Q000166:cytology; D011414:Properdin / Q000032:analysis; D011759:Pyrrolidines / Q000627:therapeutic use; D011817:Rabbits; D051381:Rats; D013154:Spleen / Q000166:cytology; D013742:Tetanus / Q000188:drug therapy / Q000276:immunology*
D004146:Dioxanes; D007106:Immune Sera; D011759:Pyrrolidines; D011414:Properdin; C021293:butyroxan; D003165:Complement System Proteins; D009113:Muramidase
Zavisimost' vyrazhennosti techeniia stolbniachnoĭ intoksikatsii ot urovnia rezistentnosti makroorganizma.