Detection of sclerosis-inducing glycosaminoglycan in the skin of an amine-induced experimental skin sclerosis.
The presence of sclerosis-inducing glycosaminoglycan in the skin was confirmed in an experimental skin sclerosis induced by a chemical compound. An experimental skin sclerosis was first produced in the mouse with bis(4-amino-3-methylcyclohexyl)methane. Out of glycosaminoglycans isolated from the slightly changed skin of this experimental skin sclerosis, the one having a heparan sulfate-like structure was able to again induce sclerotic skin changes in another mouse. The chemical composition of this sclerosis-inducing glycosaminoglycan was somewhat similar to that of the scleroderma-inducing glycosaminoglycan isolated previously from the urine of patients with systemic scleroderma.
D000818:Animals; D003514:Cyclohexylamines; D006025:Glycosaminoglycans / Q000302:isolation & purification / Q000633:toxicity*; D008297:Male; D051379:Mice; D012595:Scleroderma, Systemic / Q000139:chemically induced* / Q000503:physiopathology; D012867:Skin / Q000032:analysis
D003514:Cyclohexylamines; D006025:Glycosaminoglycans; C026295:bis(4-amino-3-methylcyclohexyl)methane