Dosage patterns of non-depolarizing neuromuscular blockers in the sheep.
Eighty per cent paralysis was induced and maintained for 90 minute in the sheep by computer-controlled injection of gallamine, pancuronium, alcuronium or d-tubocurarine, using the integrated electromyogram as a measure of neuromuscular transmission. The dosage pattern consisted of a loading phase before any IEMG depression was detected, an onset phase during which a moderate amount of drug was required to achieve increasing paralysis, and a maintenance phase during which a substantially constant and relatively low infusion rate was required. The steady state rates of infusion in microgram/kg/min during "maintenance" was found to be 6.0 for gallamine, 0.15 for pancuronium, 0.2 for alcuronium and 0.5 for d-tubocurarine.
D000443:Alcuronium / Q000008:administration & dosage; D000818:Animals; D005703:Gallamine Triethiodide / Q000008:administration & dosage; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D010197:Pancuronium / Q000008:administration & dosage; D010243:Paralysis / Q000139:chemically induced*; D012756:Sheep; D014403:Tubocurarine / Q000008:administration & dosage
D009125:Muscle Relaxants, Central; D009466:Neuromuscular Blocking Agents; D010197:Pancuronium; D005703:Gallamine Triethiodide; D000443:Alcuronium; D014403:Tubocurarine