Hepatotoxicity of enflurane in rats and its association with temperature changes.
Enflurane dissolved in oil was injected subcutaneously in 20 Wistar rats under various conditions of environmental and body temperature. Five Wistar rats (control group) received only the solvent. Liver damage and decrease of glycogen storage was observed in the group of animals where endogenous temperature was increased deliberately, while in livers of animals where environmental temperature was increased, only slight changes were observed.
D000818:Animals; D001831:Body Temperature; D004737:Enflurane / Q000633:toxicity*; D004781:Environmental Exposure; D005260:Female; D008099:Liver / Q000187:drug effects*; D051381:Rats; D013696:Temperature
D004737:Enflurane