Follicular development in the immature guinea-pig.
A method for making statistical comparisons between populations and types of antral follicles within the ovary of the immature guinea-pig is described. This was used to demonstrate that atresia in the antral follicles first appeared at around 14 days of age, but that the population of healthy antral follicles remained remarkably consistent throughout the second half of the prepubertal period, since neither the total number of healthy antral follicles nor the proportion of atretic follicles changed significantly. However, the maximum diameter of the antral follicles gradually increased with age, from 400 micron at 7 days to 1000 micron at 28 days, 4 days before the vagina first opended. Because the percentage distribution of all types of follicles was so consistent at any age, although individuals showed substantial differences in the numbers of follicles within each ovary, it is suggested that mechanisms operate which regulate the total population of antral follicles within the ovary.
D000818:Animals; D001699:Biometry / Q000379:methods; D005260:Female; D006168:Guinea Pigs / Q000254:growth & development*; D006080:Ovarian Follicle / Q000033:anatomy & histology / Q000254:growth & development*; D012741:Sexual Maturation