[Ultrastructural manifestations of early metabolic disorders in the myocardium of dogs with alloxan diabetes].
The ultrastructure of dog cardiomyocytes was studied one month after reproducing alloxan diabetes, with respect to myocardial extraction from the blood of glucose, nonesterified fatty acids, beta-lipoproteins and ketone bodies as well as to respiration in conjunction with oxidative phosphorylation of mitochondria, hexokinase and phosphorylase activity. Destructive changes in mitochondria, increased glycogen content in cardiomyocytes were revealed in the absence of glucose consumption by the myocardium which absorbed only lipoid metabolites. Lipoid inclusions were rarely seen in cardiomyocytes. The myocardium showed the increased content of lysosomes and hydrolytic phosphorylase. It is suggested that lipoid metabolites transform to glycogen, with lysosomes participating in the process.
D000496:Alloxan; D000818:Animals; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D004285:Dogs; D005260:Female; D005947:Glucose / Q000378:metabolism; D006003:Glycogen / Q000378:metabolism; D006593:Hexokinase / Q000378:metabolism; D006651:Histocytochemistry; D050356:Lipid Metabolism; D008247:Lysosomes / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000648:ultrastructure; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure*; D006005:Phosphorylases / Q000378:metabolism
D000496:Alloxan; D006003:Glycogen; D006005:Phosphorylases; D006593:Hexokinase; D005947:Glucose
Ul'trastrukturnoe proiavlenie rannikh metabolicheskikh narusheniĭ v miokarde sobak pri alloksanovom diabete.