Determination of the antispasmodic agent ethaverine in human plasma by high-performance liquid chromatography.
Ethaverine can be measured in the plasma of human subjects by reversed-phase high-performance liquid chromatography employing UV detection. The limit of detection was 2 ng/ml, and the precision was +/- 14, +/- 6 and +/- 2% at concentrations of 5, 25 and 50 ng/ml respectively. A peak mean plasma drug concentration of 20 ng/ml occurred at 1.5 h after single oral doses of a capsule formulation to human subjects, and declined with a half-life of 2.9 h.
D000284:Administration, Oral; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D007700:Kinetics; D008832:Microchemistry; D010208:Papaverine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000097:blood
C007639:ethaverine; D010208:Papaverine