[Epithelial proliferative activity of organ cultures of mouse embryonic lungs normally and under the action of urethane].
Autoradiography was used to study the proliferative activity of the epithelium of organ cultures from embryonic mouse lungs in health and under the action of urethane. Highly cancerous A and poorly cancerous C57BI mice in health and under the transplacental action of urethane were used in the experiments. In contradistinction to A mice, the proliferative activity of the epithelium from the lungs of embryonic C57BI mice proved to be stable in organotypical cultivation. Transplacental exposure to urethane in vivo induced the decreased label index only in the epithelium from the lungs of embryonic A mice. The character of the growth stimulating action of urethane and other carcinogens as well as possibility of using this criterion as rapid test for carcinogenicity and estimation of the biological subject predisposition to tumor arousal are discussed.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004848:Epithelium / Q000187:drug effects / Q000502:physiology; D008168:Lung / Q000187:drug effects / Q000196:embryology*; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D009924:Organ Culture Techniques; D014520:Urethane / Q000494:pharmacology*
D014520:Urethane
Proliferativnaia aktivnost' épiteliia organnykh kul'tur émbrional'nykh legkikh mysheĭ v norme i pri deĭstvii uretana.