Structures and antimicrobial activity of peniophorin A and B, two polyacetylenic antibiotics from Peniophora affinis Burt.
Two polyacetylenic antibiotics, peniophorin A and B, have been isolated from a strain of Peniophora affinis. Both have antibacterial and antifungal activity, but B is 3 to 20 times more active than A. Gram-positive cocci and a strain of Proteus vulgaris were especially susceptible to these two antibiotics. Both peniophorins contained an aromatic ring; B was an acid, and A was neutral. Peniophorin B was shown to be 2-(1-oxo-2,4-pentadiynl)phenyl acetic acid. The structure of A was only partially elucidated; it is suspected to be 6-[2-(1-oxo-2,4-pentadiynl)phenyl]5-methoxy-3-oxo-4-hexene-1-ol.
D000480:Alkynes / Q000302:isolation & purification / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000302:isolation & purification* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D001487:Basidiomycota / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013696:Temperature
D000480:Alkynes; D000900:Anti-Bacterial Agents; C026038:peniophorin A; C026037:peniophorin B