[Effect of trypsin on intravascular erythrocytes aggregation].
The role of proteolytic enzymes in intravascular aggregation of red cells was studied in experiments on rats by intravital microscopy. Intravenous injection of trypsin (40--50 mg/kg) combined with heparin (1000 units/kg) produces marked intravascular aggregation of red cells. Preliminary infusion of pentoxyphyllin (20 mg/kg) or acetylsalicylic acid (100 mg/kg) blocked this process. A conclusion is made about an important role of proteolytic enzymes play in the development of microcirculatory disorders. A possible mechanism of the aggregating action of trypsin and approaches to its correction are discussed.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology; D010431:Pentoxifylline / Q000494:pharmacology; D051381:Rats; D014357:Trypsin / Q000494:pharmacology*
D006493:Heparin; D014357:Trypsin; D001241:Aspirin; D010431:Pentoxifylline
Vliianie tripsina na vnutrisosudistuiu agregatsiiu éritrotsitov.