title: Equine verminous arteritis; efficiency and speed of larvicidal acitivty as influenced by dosage of albendazole.
abstract: Albendazole was effective in destroying Strongylus vulgaris larvae in verminous lesions of the cranial mesenteric artery when administered as a 20% suspension by stomach tube to ponies. Fifty mg/kg body weight administered twice a day for 2 days caused death and gradual disintegration of larvae over a period of 3 to 6 weeks with mild toxic signs appearing in 3 of 11 ponies. Higher total doses of albendazole (50 mg/kg twice a day for 4 days and 25 mg/kg three times a day for 5 days) lead to more rapid disintegration of the larvae but fatal toxicity was observed in 3 of 6 ponies so treated. In all cases, resolution of verminous arterial lesions was delayed until larva remains had disappeared from the lesions. A non-parametric analysis was applied to combined radiographic, pathologic and parasitologic observations and data for testing their statistical significance
mesh_terms: D000284:Administration, Oral; D015766:Albendazole; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D001167:Arteritis / Q000188:drug therapy / Q000473:pathology / Q000662:veterinary*; D001562:Benzimidazoles / Q000008:administration & dosage* / Q000627:therapeutic use / Q000633:toxicity; D006736:Horses; D007814:Larva; D008638:Mesenteric Arteries / Q000473:pathology; D013319:Strongyle Infections, Equine / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000871:Anthelmintics; D001562:Benzimidazoles; D015766:Albendazole