Effect of combined misonidazole and d(50)-Be neutrons on a human melanoma transplanted into nude mice.
This paper reports the effect of two different doses (0.1 and 1  mg/g) of misonidazole on the radiosensitivity of human Na 11 melanoma transplanted into athymic nude mice. The mice were irradiated with 50 MeV neutrons. The end point was the in vitro colony-forming assay. Repair of potentially lethal damage following neutron irradiation was comparable to that observed after gamma irradiation. This repair was no longer detectable when 1 mg/g of misonidazole was used. When the 1 mg/g dose was used, the observed enhancement ratios after neutron irradiation were 1.52 for immediate plating and 1.87 for delayed plating. No toxic effect of the drug itself could be detected.
D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects / Q000528:radiation effects; D004260:DNA Repair; D005214:Fast Neutrons / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D007274:Injections, Intraperitoneal; D008545:Melanoma / Q000628:therapy*; D051379:Mice; D008819:Mice, Nude; D008920:Misonidazole / Q000008:administration & dosage*; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000628:therapy; D009502:Neutrons / Q000627:therapeutic use; D009593:Nitroimidazoles / Q000008:administration & dosage*; D011879:Radiotherapy Dosage; D013997:Time Factors; D014183:Transplantation, Heterologous
D009593:Nitroimidazoles; D008920:Misonidazole