Familial hyper-alpha-lipoproteinemia in 26 kindreds.
The inheritance of familial hyper-alpha-lipoproteinemia was investigated in 161 individuals in 11 black kindreds and 15 white kindreds. After age and sex adjustment, the distribution of high density lipoprotein-cholesterol (C-HDL) in the relatives of probands was examined for evidence of bimodality. In whites, bimodality appeared to be present, with one mode at about 46 mg/dl and the other at about 69 mg/dl. In blacks, there was little convincing evidence of bimodality. In the white kindreds, it appeared that one factor with a relatively large effect is causing the familial aggregation of high C-HDL levels; this factor could be a major gene.
D000293:Adolescent; D000328:Adult; D000368:Aged; D044383:Black People; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000235:genetics*; D008075:Lipoproteins, HDL / Q000097:blood*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood; D044465:White People
D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D002784:Cholesterol