Prolactin secretion in man following acute and long-term cimetidine administration.
In 20 patients with duodenal ulcer we measured serum prolactin levels following acute and long-term cimetidine administration. In addition, in 20 healthy volunteers we studied the effect of pre-treatment with bromocriptine, meterogline, nomifensine and cryroheptadine on cimetidine-induced prolactin release. Intravenous cimetidine stimulated prolactin secretion in patients and in normal subjects. In the latter, bromocroptine and metergoline pre-administration blunted the release of prolactin in response to iv cimetidine whereas nomifensine and cyproheptadine were ineffective. Long-term treatment with cimetidine (1.2 g daily for 3 months) had no effect on prolactin secretion in the 20 patients studied. No incidence of gynaecomastia, galactorrhoea or disorders of the menstual cycle was observed.
D000328:Adult; D001971:Bromocriptine / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology*; D003533:Cyproheptadine / Q000494:pharmacology; D004381:Duodenal Ulcer / Q000188:drug therapy / Q000503:physiopathology; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D009627:Nomifensine / Q000494:pharmacology; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D012636:Secretory Rate / Q000187:drug effects; D013997:Time Factors
D006146:Guanidines; D008711:Metergoline; D009627:Nomifensine; D003533:Cyproheptadine; D001971:Bromocriptine; D002927:Cimetidine; D011388:Prolactin