Uptake of asialoglycophorin-liposomes by the perfused rat liver.
Asialoglycophorin-containing liposomes and their contents (125I-labeled bovine serum albumin) were taken up by a perfused rat liver with subsequent digestion of their protein components. The uptake of these liposomes required Ca2+ as well as desialylation. The process was inhibited partially by asialofetuin and completely by further addition of asialoglycophorin to the perfusate.
D000818:Animals; D001212:Asialoglycoproteins; D002118:Calcium / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D008081:Liposomes / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D012711:Serum Albumin, Radio-Iodinated / Q000378:metabolism
D001212:Asialoglycoproteins; D006023:Glycoproteins; D008081:Liposomes; D012711:Serum Albumin, Radio-Iodinated; C026503:asialoglycophorin; D002118:Calcium