Selective uptake of cadmium by the parenchyumal cells of liver.
The uptake of cadmium in vivo into parenchymal and non-parenchymal (sinusoidal) cells of the liver was studied by a cell-separation technique. Liver parenchymal cells accumulate cadmium more readily than do non-parenchymal cells and synthesize metallothionein. It is proposed that cadmium uptake and metabolism from injected CdCl2, is restricted almost exclusively to the liver parenchymal cells.
D000818:Animals; D002104:Cadmium / Q000378:metabolism*; D002469:Cell Separation; D005260:Female; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008668:Metallothionein / Q000096:biosynthesis; D051381:Rats
D002104:Cadmium; D008668:Metallothionein