Relationship of octanol/water partition coefficient and molecular weight to rat brain capillary permeability.
The rat brain capillary permeability coefficient was determined for 27 compounds. The relationship of permeability to octanol/water partition coefficient and molecular weight was found to be predictable for drugs with molecular weights less than 400.
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000098:blood supply; D002199:Capillary Permeability; D008297:Male; D008954:Models, Biological; D008970:Molecular Weight; D051381:Rats; D011916:Rats, Inbred F344; D012995:Solubility; D013329:Structure-Activity Relationship