Studies on the ionophorous antibiotics. XXIV. Leuseramycin, a new polyether antibiotic produced by Streptomyces hygroscopicus.
A new antibiotic leuseramycin has been isolated from the cultured mycelium of the strain of Streptomyces hygroscopicus TM-531. Physicochemical data, in particular those of 1H- and 13C-NMR spectra, revealed that leuseramycin is closely related to dianemycin in its structure, the former having a methyl group in place of the hydroxymethyl group at C-30. It is active against Gram-positive bacteria, some phytopathogenic fungi and some protozoa.
D000900:Anti-Bacterial Agents / Q000032:analysis* / Q000096:biosynthesis / Q000494:pharmacology; D000935:Antifungal Agents; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004987:Ethers / Q000032:analysis / Q000096:biosynthesis / Q000494:pharmacology; D007476:Ionophores / Q000032:analysis* / Q000096:biosynthesis / Q000494:pharmacology; D013302:Streptomyces / Q000254:growth & development / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D004987:Ethers; D007476:Ionophores; C025511:leuseramycin