title: Zollinger-Ellison syndrome: a clinical update.
abstract: The Zollinger-Ellison syndrome (ZES) is characterized by gastrin-producing tumors, gastric acid hypersecretion, peptic ulcers, and diarrhea. ZES may be associated with nonpancreatic endocrine tumors as part of the multiple endocrine adenomatosis-type 1 syndrome. The diagnosis of ZES can be confirmed in patients with a suggestive clinical picture and excessive gastric acid secretion by the finding of a markedly elevated fasting serum gastrin level or characteristic gastrin response to provocative testing. Standard treatment of ZES has traditionally been surgical. With the introduction of H2-histamine receptor antagonists, however, many patients can now be managed successfully with cimetidine alone, or cimetidine plus vagotomy, when no resectable gastrinoma is present.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D005260:Female; D005755:Gastrins / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000175:diagnosis* / Q000628:therapy*
chemical_list: D005755:Gastrins