[Does the intramammary carcinomatous lymphagiosis have prognostic significance in nodal-negative breast neoplasms?].
This study represents an attempt to analyse the prognostic significance of intramammary lymphangiosis carcinomatosa (ILC) in nodal-negative mammary carcinomas. It is based on 125 cases of nodal-negative mammary carcinomas covered by the prospective OSAKO study (reference number 06/74). Histological sections of the mastectomy preparations were examined for the presence of ILC. We found it difficult to diagnose the presence of lymphangiosis carcinomatosa in mammary gland tissue in cases of mammary carcinoma on the basis of histological findings. Applying strictest criteria, ILC was found in 11 of the 125 cases (8.8%). Due to the small number of carcinomas with ILC and to the average observation period of only 3 1/2 years it is as yet impossible to reach any statistically significant conclusions regarding rate of relapse, appearance of distant metastases and deaths. It is, however, striking that 2 of 11 patients with ILC died as a result of their carcinomas, whereas there were only 3 carcinoma deaths out of 107 cases in the group without ILC. It is at present too early to decide whether ILC is an appropriate criterion to use in selecting cases of nodal-negative mammary carcinoma with a poor prognosis, meriting the administration of adjuvant chemotherapy.
D001943:Breast Neoplasms / Q000175:diagnosis* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008202:Lymphangioma / Q000150:complications*; D011379:Prognosis
Hat die intramammäre Lymphangiosis carcinomatosa beim nodal-negativen Mammakarzinom eine prognostische Bedeutung?