Changes in patterns of S-adenosylmethionine synthetases in fetal and postnatal rat liver.
Three isozymes of S-adenosylmethionine synthetase have been measured in the livers of rats from fetal life to maturity. A greater part of gamma-type enzyme is shown to be present in fetus and is joined by alpha- and beta-types during development. The amount of beta-type enzyme activated by dimethyl sulfoxide is very low in the fetus and rises sharply until about the 15th day after birth. The alpha-type enzyme appears after birth and increases in amount to the tenth day.
D000367:Age Factors; D000818:Animals; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005865:Gestational Age; D007527:Isoenzymes / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000196:embryology / Q000201:enzymology* / Q000254:growth & development; D008716:Methionine Adenosyltransferase / Q000378:metabolism*; D008970:Molecular Weight; D051381:Rats; D014018:Tissue Distribution; D014166:Transferases / Q000378:metabolism*
D007527:Isoenzymes; D014166:Transferases; D008716:Methionine Adenosyltransferase; D004121:Dimethyl Sulfoxide