Gene constellation of live influenza A vaccines.
The genotypic composition of several H3N2 vaccinal strains made from PR/8/34 and different wild isolates has been determined. The results suggested that specific gene constellations at the level of the 3 largest RNA fragments, coding the 3 "polymerase proteins" are responsible for their consistent attenuation.
D005814:Genes, Viral; D009980:Influenza A virus / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D007252:Influenza Vaccines; D011995:Recombination, Genetic; D014613:Vaccines, Attenuated; D014764:Viral Proteins / Q000235:genetics
D007252:Influenza Vaccines; D014613:Vaccines, Attenuated; D014764:Viral Proteins