title: Deposition of human labeled platelets to damaged rabbit aorta before and after use of sulfinpyrazone in patients with acute myocardial infarction.
abstract: Platelets from patients with acute myocardial infarction were labeled with 51Cr and reconstituted whole blood. The endothelium of rabbit aorta was removed, and segments of the inverted aorta placed on a Plexiglas rod in a perfusion chamber, and the deposition of platelets on the aorta was calculated by radioactivity measurement. In all 8 patients the deposition of platelets was reduced after ingestion of 800 mg of sulfinpyrazone daily for 4 weeks.
mesh_terms: D000818:Animals; D001011:Aorta / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy; D010477:Perfusion; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011817:Rabbits; D013442:Sulfinpyrazone / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D013442:Sulfinpyrazone