title: On the mode of action of ergometrine in the isolated dog coronary artery.
abstract: Coronary vasoconstrictor responses to ergometrine were examined in spiral coronary arterial preparations of dogs. Either ergometrine or serotonin (5-HT) produced dose-dependent contractions of the strips. Methysergide significantly depressed the contractions induced by ergometrine or 5-Ht. Dihydroergotamine and phentolamine depressed constrictor responses to ergometrine, while phenoxybenzamine did not. The 5-HT antagonistic action of phentolamine was stronger than that of phenoxybenzamine. The results indicate that ergometrine may act on coronary arteries mainly through activation of 5-HT receptors.
mesh_terms: D000818:Animals; D001158:Arteries / Q000187:drug effects; D003331:Coronary Vessels / Q000187:drug effects*; D004087:Dihydroergotamine / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004874:Ergonovine / Q000494:pharmacology*; D066298:In Vitro Techniques; D008784:Methysergide / Q000494:pharmacology; D010643:Phenoxybenzamine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects*
chemical_list: D011985:Receptors, Serotonin; D010643:Phenoxybenzamine; D012701:Serotonin; D004087:Dihydroergotamine; D004874:Ergonovine; D008784:Methysergide; D010646:Phentolamine