Structure-neuromuscular blocking activity relationships of ketophosphonium salts.
Three ketophosphonium salts containing a morpholino group were prepared and evaluated for their neuromuscular blocking effect. Solution and crystal conformations were studied. An attempt was made to explain, in structural terms, different activity levels in connection with the interatomic distances.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009466:Neuromuscular Blocking Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D009861:Onium Compounds / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D013329:Structure-Activity Relationship; D014961:X-Ray Diffraction
D009466:Neuromuscular Blocking Agents; D009861:Onium Compounds