New compounds: N1,N8-bis(2,3-dihydroxybenzoyl)spermidine and analogs as potential iron-chelating drugs.
N1,N8-bis(2,3-dihydroxybenzoyl)spermidine was synthesized and evaluated as an iron-chelating drug. Homologs were prepared and evaluated together with a series of N,N'-bis(2,3-dihydroxybenzoyl)-alpha,omega-diaminoalkanes. Analogous 2-hydroxbenzoyl compounds also were synthesized and evaluated.
D055598:Chemical Phenomena; D002621:Chemistry; D007502:Iron Chelating Agents / Q000138:chemical synthesis; D013095:Spermidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis
D007502:Iron Chelating Agents; C026327:N(1),N(8)-bis(2,3-dihydroxybenzoyl)spermidine; D013095:Spermidine