Cecal toxin(s) from guinea pigs with clindamycin-associated colitis, neutralized by Clostridium sordellii antitoxin.
The cecal contents of guinea pigs with clindamycin-associated colitis contained a heat-labile toxin. This toxin was lethal for guinea pigs and mice, produced vascular permeability in the skin of rabbits, and was cytotoxic in tissue culture. The lethality in mice, vascular permeability in rabbit skin, and cytotoxicity in tissue culture monolayers were neutralized by Clostridium sordellii antitoxin.
D000818:Animals; D000992:Antitoxins; D001427:Bacterial Toxins / Q000032:analysis* / Q000633:toxicity; D002199:Capillary Permeability; D002432:Cecum / Q000032:analysis*; D002981:Clindamycin / Q000009:adverse effects*; D003013:Clostridium; D003092:Colitis / Q000209:etiology* / Q000382:microbiology; D006168:Guinea Pigs; D051379:Mice; D009500:Neutralization Tests; D011817:Rabbits
D000992:Antitoxins; D001427:Bacterial Toxins; D002981:Clindamycin