High ionic strength: its significance in immunosurveillance against tumor cells in sharks and rays (elasmobranchs).
It is postulated that the rarity of tumors in elasmobranchs is due to the high ionic strength in their tissues, which is equivalent to a high body temperature. Such conditions should lead to the elimination of variable antigenicity and 100% immune surveillance. The basis for this theory is that the repressor molecular for mitosis, not binding to its operator site cannot bind anywhere.
D000818:Animals; D008938:Mitosis; D009369:Neoplasms / Q000453:epidemiology / Q000662:veterinary*; D009994:Osmolar Concentration; D012754:Sharks / Q000097:blood / Q000502:physiology*