Bronchiolar pathology. III. Lung tissue restructuration by experimental bronchiolar lesions.
Repeated intratracheal administration of neutral or acid solutions of the detergent Perlan blue in rabbits determined intralobular damage of bronchioli and of the bronchiolo-alveolar passages. This lesional process was followed by regenerating proliferative responses of the bronchiolar epithelial cells and by the development of a granulation tissue due to proliferation of the damaged endothelia. The granulation tissue delimited the damaged area and led to the restructuration of a wide lung tissue area. The lesional process was progressive and its extension and intensity depended on the repeated injection of the detergent solution and mainly on its acidity. The above technique might be considered as an experimental model for bronchiolar pathology.
D000818:Animals; D001980:Bronchi / Q000473:pathology*; D003902:Detergents; D004195:Disease Models, Animal; D006851:Hydrochloric Acid; D008171:Lung Diseases / Q000139:chemically induced / Q000473:pathology*; D011650:Pulmonary Alveoli / Q000473:pathology; D011817:Rabbits; D012965:Sodium Chloride
D003902:Detergents; D012965:Sodium Chloride; D006851:Hydrochloric Acid