Furosemide in patients with heart failure: shift in dose-response curves.
We studied 10 patients with congestive heart failure to assess the dynamics of their response to 40 mg of furosemide. Patients excreted less sodium than normal controls: 142 +/- 36 and 245 +/- 16 mEq/4 hr (p < 0.05). Patients delivered the same amount of furosemide into the urine--14.9 +/- 2.0 and 18.7 +/- 2.1 mg/4 hr (p < 0.20)--but the time course of delivery differed. Normal subjects had a sigmoid-shaped curve when furosemide excretion rate was related to response. All patients but one had shifts in this curve and for a number of patients the configuration differed substantially from a sigmoid curve.
D000328:Adult; D000368:Aged; D004305:Dose-Response Relationship, Drug; D005260:Female; D005665:Furosemide / Q000494:pharmacology / Q000627:therapeutic use / Q000652:urine*; D006333:Heart Failure / Q000188:drug therapy / Q000652:urine*; D006801:Humans; D007674:Kidney Diseases / Q000652:urine; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D005665:Furosemide