Study on serotoninergic mechanisms of compensatory ovarian hypertrophy in rats.
The increase of brain serotonin level following the treatment of hemicastrate adult female rats with L-tryptophane or Agr-1240 inhibits the compensatory ovarian hypertrophy (COH). The blockade of central serotoninergic receptors with typindole abolished the suppressive effect of estrogen on COH. The administration of L-DOPA abolished this effect of typindole. The dose-related inhibitory effect of melatonin on COH was shown. Serotoninergic systems are suggested to participate in the realisation of the negative feedback action of estrogen. The threshold of the hypothalamo-pituitary sensitivity to the suppressive estrogen effect is elevated in both pinealectomized and constant light-exposed rats.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D002369:Castration; D004054:Diethylstilbestrol / Q000031:analogs & derivatives / Q000494:pharmacology; D005260:Female; D006984:Hypertrophy; D007211:Indoles / Q000494:pharmacology; D007980:Levodopa / Q000494:pharmacology; D008550:Melatonin / Q000494:pharmacology; D009025:Morpholines / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects / Q000473:pathology*; D010870:Pineal Gland / Q000502:physiology; D011724:Pyridazines / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D014364:Tryptophan / Q000494:pharmacology
D007211:Indoles; D009025:Morpholines; D011724:Pyridazines; C006149:minaprine; D012701:Serotonin; D007980:Levodopa; D004054:Diethylstilbestrol; D014364:Tryptophan; D008550:Melatonin; C013716:tipindole; C000937:diethylstilbestrol dipropionate