Mercapto steroids in protection against mercury and lead poisoning.
When thiocholesterol is administered as liposomes, it provides significant protection against methylmercuric chloride in mice when given in three intraperitoneal injections, 0.5 hr before and 2 and 8 hr after the methylmercuric chloride. Thiositosterol, 5 alpha-cholestane-2 beta, 3 alpha-dithiol, and 5 beta-cholane-3 beta, 24-dithiol also are active, but 3 alpha-mercapto-5 alpha-pregnan-20-one, 6 beta-mercapto-5 alpha-cholestane-3 beta, 5 alpha-diol, 3 beta-mercapto-5 beta-cholanic acid, and adamantanethiol are ineffective under these conditions. Adamantanethiol is somewhat effective when administered in soybean oil. Cholestanyl amine was treated with acetylthiosuccinic anhydride to give the half amide; cleavage with hydroxylamine liberated the thiol group. This product is active against both methylmercuric chloride and lead nitrate.
D000818:Animals; D001681:Biological Assay; D007855:Lead Poisoning / Q000517:prevention & control*; D008297:Male; D008630:Mercury Poisoning / Q000517:prevention & control*; D051379:Mice; D013256:Steroids / Q000627:therapeutic use*; D013329:Structure-Activity Relationship; D013438:Sulfhydryl Compounds / Q000138:chemical synthesis / Q000627:therapeutic use*; D013997:Time Factors
D013256:Steroids; D013438:Sulfhydryl Compounds