A simple method for the preparation of D-alpha-aminoadipic acid.
High quantity (1 g and more) of racemically and chromatographically pure D-alpha-aminoadipic acid was prepared by selective metabolism of the L-isomer of the commercially available DL-alpha-aminoadipate by Pseudomonas putida. The overall yield of this preparation averaged 40%. The final product has [a]25D value of -25 degrees. This procedure can be useful in the synthesis of high purity D-alpha-amino-adipate, a compound shown recently to be a useful tool in the study of neurotransmission mechanism mediating synaptic excitation.
D015074:2-Aminoadipic Acid / Q000096:biosynthesis*; D000600:Amino Acids, Dicarboxylic / Q000096:biosynthesis*; D002854:Chromatography, Paper; D003470:Culture Media; D007700:Kinetics; D011549:Pseudomonas / Q000378:metabolism*; D013237:Stereoisomerism
D000600:Amino Acids, Dicarboxylic; D003470:Culture Media; D015074:2-Aminoadipic Acid