Sister-chromatid exchanges and cytotoxicity in cultured Indian muntjac cells treated with alkylating agents.
6 monofunctional alkylating mutagens/carcinogens -- 4 N-nitroso and 2 methanesulfonate compounds -- differed in their efficiency for inducing sister-chromatid exchanges (SCEs) when normalized on cytotoxicity. SCE induction occurred only at highly cytotoxic doses. Ethylating agents were, on a molar basis, generally less potent inducers of SCEs, and they were also less cytotoxic than the corresponding methylating agents. The observed differential action spectrum of the 6 alkylating agents is discussed in the light of recent ideas on the interaction between alkylating mutagens with DNA and the role of specific DNA lesions in the formation of SCEs.
D000477:Alkylating Agents / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D002875:Chromosomes / Q000187:drug effects*; D003434:Crossing Over, Genetic; D003670:Deer / Q000235:genetics*; D004305:Dose-Response Relationship, Drug; D009153:Mutagens; D009603:Nitroso Compounds / Q000494:pharmacology; D012854:Sister Chromatid Exchange
D000477:Alkylating Agents; D009153:Mutagens; D009603:Nitroso Compounds