Podophyllum: suspected teratogenicity from topical application.
A case demonstrating suspected teratogenic effects of topical podophylium is presented. Podophyllum resin was applied five times for a duration of 4 hr from the 23rd to the 29th week of pregnancy. At birth a simian crease on the left hand and a preauricular skin tag were noted. It is suggested that podophyllum be avoided during pregnancy. Alternative treatment for warts of the vaginal, perineal, or anal area are presented.
D000014:Abnormalities, Drug-Induced / Q000209:etiology; D000287:Administration, Topical; D000328:Adult; D002738:Chloroquine / Q000633:toxicity; D003218:Condylomata Acuminata / Q000188:drug therapy; D005260:Female; D006801:Humans; D011033:Podophyllin / Q000633:toxicity*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000188:drug therapy; D013723:Teratogens
D013723:Teratogens; D002738:Chloroquine; D011033:Podophyllin