[Influence of propranolol and digoxin on the leftventricular pressure-volume-relation of the guinea pig (author's transl)].
Leftventricular parameters of pressure, volume and contractility were recorded in the guinea pig treated with propranolol and digoxin. Propranolol shifts the isovolumetric pressure-volume-relation to higher enddiastolic volume. Pressure, rate of pressure rise, and heart rate considerably decrease. Cardiodepression of high-dose propranolol treatment is reversed in part by digoxin. Conclusions for application of beta-blockers, especially in imparied ventricular function, are discussed.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004077:Digoxin / Q000494:pharmacology*; D006168:Guinea Pigs; D006352:Heart Ventricles; D009200:Myocardial Contraction / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*
D004077:Digoxin; D011433:Propranolol
Einfluss von Propranolol und Digoxin auf die linksventrikulären Druck-Volumen-Beziehungen beim Meerschweinchen.