[Investigation or oral substitution of iron and folic acid (author's transl)].
In a study of apparently healthy volunteers (5 male, 5 female) the bioavailability of iron and folacin was calculated using Tardyferon¿ resp. Tardyferon-Fol¿ as test substances. Blood samples for serum iron and folacin level determinations were obtained before and 1/2, 1, 2, 4, 6 and 8 hours after dosing. Because of the diurnal fluctuation of serum iron and folate levels, baseline levels were obtained at the corresponding 0, 1/2, 1, 2, 4, 6 and 8 hours one week prior to the study. Serum iron and folacin levels above the baseline values and the area under the curve were calculated. The data suggested a good bioavailability of the tested substances. The folacin absorption after a single dose of 0.35 mg produced a maximal serum concentration of mean = 28 ng/ml. Twice the dose resulted in a maximum of serum folacin level of mean = 51 ng/ml. The oral administration of 80 mg Fe2+ resp. 160 mg Fe2+ resulted in a significant increase of the serum iron levels, too.
D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D004338:Drug Combinations / Q000008:administration & dosage; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage; D005492:Folic Acid / Q000008:administration & dosage / Q000097:blood*; D006801:Humans; D007501:Iron / Q000097:blood*; D007700:Kinetics; D008297:Male; D009077:Mucins / Q000008:administration & dosage
D004338:Drug Combinations; D005296:Ferrous Compounds; D009077:Mucins; C009380:ferrous sulfate, mucin drug combination; C026299:tardyferon fol; D005492:Folic Acid; D007501:Iron
Untersuchungen zur oralen Eisen-Folsäure-Substitution.