title: The effects of the fumes from heated rosin (colophony) on tissue glutathione and xenobiotic metabolism in rat lung and liver.
abstract: Rats were exposed to the fumes from heated (360 degrees C) rosin for two weeks. The particulate concentration of the fumes was 220 mg/m3. Hepatic reduced glutathione (GSH) levels were decreased by 13% while no effect on GSH in the lungs was detected. In the liver the ethoxycoumarin O-deethylation and NADPH-cytochrome c reduction were enhanced 20% by the fumes. Hepatic cytochrome P-450 and aryl hydrocarbon hydroxylase were unaffected. An inhibition of pulmonary ethoxycoumarin O-deethylation (24%) and hepatic p-nitroanisole demethylation (29%) was noted in exposed rats.
mesh_terms: D000818:Animals; D004851:Epoxide Hydrolases / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism*; D006358:Hot Temperature; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D012116:Resins, Plant / Q000494:pharmacology*; D014018:Tissue Distribution
chemical_list: D004364:Pharmaceutical Preparations; D012116:Resins, Plant; C013893:rosin; D004851:Epoxide Hydrolases; D005978:Glutathione