Intrarenal blood flow distribution in the genetically hypertensive rat.
Distribution of intrarenal blood flow has been measured in genetically hypertensive (GH) and normotensive (N) rats (aged 17--23 weeks) by a 133Xe washout technique without opening the abdominal cavity. Three different specific flow compartments were found in the rats. The distribution of the intrarenal blood flow to the fast compartment was reduced in the GH rats when compared with the N rats and the rate of flow in it was also reduced. The flow rate in the second compartment was the same in the two strains, the distribution to it being relatively greater in the GH rats. The mean renal blood flow index (in ml/min/g of kidney) was reduced in the GH rats. It is not at present clear whether these differences are due to the hypertension or represent a causative factor in the hypertension.
D000818:Animals; D006973:Hypertension / Q000235:genetics / Q000473:pathology* / Q000503:physiopathology; D007668:Kidney / Q000098:blood supply* / Q000503:physiopathology; D051381:Rats; D011919:Rats, Inbred Strains; D012039:Regional Blood Flow