Effect of bioflavonoids on the urinary excretion of hydroxyproline, hydroxylysyl glycosides and hexosamine in adjuvant arthritis.
The effects of (+)--Catechin (AC) and 0--(beta hydroxyethyl) rutosides (HR) on the urinary collagen metabolites were studied up to 49 days in rats with adjuvant-induced arthritis. The elevated levels of urinary total, non-dialysable and dialysable hydroxyproline, hydroxylysyl glycosides and total hexosamine in the arthritic animals were found to be slightly decreased in the acute phase and significantly decreased in the chronic phase of the disease due to the administration of bioflavonoids. Of the two bioflavonoids tests, CA was found to afford more protective action than HR.
D000818:Animals; D001168:Arthritis / Q000652:urine*; D001169:Arthritis, Experimental / Q000652:urine*; D001835:Body Weight; D005419:Flavonoids / Q000494:pharmacology*; D006027:Glycosides / Q000652:urine*; D006595:Hexosamines / Q000652:urine*; D006901:Hydroxylysine / Q000031:analogs & derivatives* / Q000652:urine; D006909:Hydroxyproline / Q000652:urine*; D008297:Male; D051381:Rats
D005419:Flavonoids; D006027:Glycosides; D006595:Hexosamines; C022819:hydroxylysine glycoside; D006901:Hydroxylysine; D006909:Hydroxyproline