title: [Mutagenic action of methandrostenolone].
abstract: Metandrostenolone provoked no chromosomal aberrations in bone marrow cells of mice, but induced dominant lethal mutations in sexual cells of males in the stages of early spermatids and spermatocytes. This was established from increased preimplantation lethality weeks 3, 4 and 5 and from postimplantation embryonic lethality weeks 3, 5 and 6 after the experiment was started.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D005260:Female; D005799:Genes, Dominant / Q000187:drug effects; D005804:Genes, Lethal / Q000187:drug effects; D008297:Male; D008677:Metaphase / Q000187:drug effects; D008696:Methandrostenolone / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009153:Mutagens; D011247:Pregnancy; D012098:Reproduction / Q000187:drug effects
chemical_list: D009153:Mutagens; D008696:Methandrostenolone
vernacular_title: Izuchenie mutagennogo deĭstviia metandrostenolona.