A report on the pathology of type A botulism.
An autopsy case of type A botulism, a sacrifice during the first outbreak in Japan, was presented. The patient exhibited typical neuromuscular symptoms and died on the 8th day from the onset of illness. Type A Clostridium botulinum was demonstrated from the stools and the toxin from the blood serum during the course of disease. The infection source of botulinus bacilli, however, was not clarified. The autopsy diagnoses were made as follows; 1) type A botulism, 2) bronchopneumonia, 3) respirator brain, 4) congestion, 5) hemorrhage in vagal nerve, myocardium and endometrium, 6) gastric erosion, 7) cloudy swelling of kidneys, 8) enterocolitis, 9) focal necrosis of liver and adrenals, 10) demyelination of cranial nerves, and 11) focal hyaline degeneration of striated and smooth muscles and myocardium. The botulinus toxin was confirmed from the samples of cardiac blood or autopsy.
D001905:Botulinum Toxins / Q000032:analysis; D001906:Botulism / Q000473:pathology*; D001921:Brain / Q000473:pathology; D002648:Child; D003391:Cranial Nerves / Q000473:pathology; D003711:Demyelinating Diseases / Q000473:pathology; D005260:Female; D006801:Humans; D007422:Intestines / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D009206:Myocardium / Q000473:pathology; D013270:Stomach / Q000473:pathology
D001905:Botulinum Toxins