title: Human percutaneous penetration of hydrocortisone: the vulva.
abstract: Percutaneous penetration of 14C hydrocortisone through normal vulvar skin (labia majora) was measured in six subjects and compared with that of the forearm. Of the topically applied hydrocortisone 7.7% penetrated vulvar skin whereas 1.3% penetrated forearm skin. This regional variation of percutaneous penetration may have toxicologic and therapeutic significance.
mesh_terms: D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism* / Q000652:urine; D010539:Permeability; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption; D014844:Vulva / Q000378:metabolism*
chemical_list: D006854:Hydrocortisone