Behavioral effects of methyl parathion and toxaphene exposure in rats.
The behavior of rats exposed peri- and postnatally to methyl parathion (MP) and toxaphene (T) was examined with a variety of maturational and learning tests. Females received daily oral doses of 1.0 mg/kg MP or 1.0 mg/kg MP + 2.0 mg/kg T between Days 7-15 of pregnancy. With T alone, rats of the postnatal group were dosed daily with 6 mg/kg for 21 days, while in the perinatal study females received 6 mg/kg daily from Day 7 of pregnancy until parturition. Rat pups exposed to sublethal doses of MP and T in combination or alone demonstrated few significant changes in learning ability as measured by a simple two-choice maze, motor skills, or behavior.
D000284:Administration, Oral; D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology; D001522:Behavior, Animal / Q000187:drug effects*; D005260:Female; D007306:Insecticides / Q000494:pharmacology*; D007858:Learning / Q000187:drug effects; D008431:Maternal-Fetal Exchange; D008743:Methyl Parathion / Q000494:pharmacology*; D010278:Parathion / Q000031:analogs & derivatives*; D011247:Pregnancy; D051381:Rats; D014112:Toxaphene / Q000494:pharmacology*
D007306:Insecticides; D008743:Methyl Parathion; D010278:Parathion; D014112:Toxaphene