Effects of endotoxin-tolerance on in vivo drug metabolism in mice.
Acute doses of endotoxin and the induction of endotoxin-tolerance lowered the apparent in vivo rates of hexobarbital and zoxazolamine metabolism in mice. Acute doses of endotoxin increased the duration of narcosis induced by these two compounds to a greater extent than did induction of the endotoxin-tolerant state. In endotoxin-tolerant mice, however, acute endotoxin treatment did not extend hexobarbital sleeping or zoxazolamine paralysis times beyond those noted in endotoxin-tolerant mice given no acute endotoxin.
D000818:Animals; D004347:Drug Interactions; D004361:Drug Tolerance; D004731:Endotoxins / Q000494:pharmacology*; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010243:Paralysis / Q000139:chemically induced; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D011135:Polysaccharides, Bacterial / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects; D013997:Time Factors; D015049:Zoxazolamine / Q000494:pharmacology
D004731:Endotoxins; D004364:Pharmaceutical Preparations; D011135:Polysaccharides, Bacterial; D015049:Zoxazolamine; D006591:Hexobarbital