title: Hormonal and local agents as extracellular regulators of cartilage growth measured by the rate of proteoglycan synthesis. A hypothesis.
abstract: Following the rate of proteoglycan synthesis as the metabolic parameter of the growth of cartilage cells, indicates that hormonal and local agents are two distinct types of extracellular regulators responsible for altering the basic metabolic rates of cells. Such changes in growth rate occur regularly at physiological developmental stages (e.g., during embryonic life and at advancing age), and at pathological events (e.g., wounds and repair).
mesh_terms: D000818:Animals; D002356:Cartilage / Q000254:growth & development*; D002478:Cells, Cultured; D006025:Glycosaminoglycans / Q000378:metabolism; D006133:Growth Substances / Q000494:pharmacology; D008954:Models, Biological; D011509:Proteoglycans / Q000096:biosynthesis*; D013268:Stimulation, Chemical
chemical_list: D006025:Glycosaminoglycans; D006133:Growth Substances; D011509:Proteoglycans