title: [The inhibition of inflammation by the promotion of spontaneous healing with L-carnosine (author's transl)].
abstract: In 1970 Nagai and associates discovered the granulation promotive effect of L-carnosine. Its effective dosage roughly corresponds to 1/35 of what is naturally contained in the m. gastrocnemius of experimental rats, as little as 20 mg/kg IP being effective. Its works synergically with cortisone in the anti-edematous and granular promotive actions. In 1975 the author regarded L-carnosine as a natural chemical mediator in the promotion of spontaneous healing. This effect is believed to make possible the elimination of inflammation by promoting spontaneous healing, which has been lacking in the previous concept of an inflammatory mechanism. The author's coworker confirmed the pronounced effect of L-carnosine in the promotion of wound healing and the inhibition of L-carnosine in the promotion of associated inflammation in dental extraction with no conjoint administration of other anti-inflammatory drugs.
mesh_terms: D000328:Adult; D000818:Animals; D002336:Carnosine / Q000494:pharmacology / Q000627:therapeutic use*; D004151:Dipeptides / Q000494:pharmacology / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006097:Granulation Tissue / Q000187:drug effects; D006168:Guinea Pigs; D006801:Humans; D007249:Inflammation / Q000517:prevention & control*; D008297:Male; D008875:Middle Aged; D009059:Mouth Diseases / Q000188:drug therapy; D011817:Rabbits; D051381:Rats; D014076:Tooth Diseases / Q000188:drug therapy; D014081:Tooth Extraction; D014945:Wound Healing / Q000187:drug effects
chemical_list: D004151:Dipeptides; D002336:Carnosine
vernacular_title: Entzündungshemmung durch die Förderung der spontanen Heilung mittels L-Carnosin.