[Effect of kidney antigen sensitized lymphoid cells administered to female mice on the state of their kidneys and offspring].
Lymphoid cells from syngeneic donors suffering from nephritis were injected into female rats over varying periods of pregnancy (days 10-18) and before mating. Apart from weight reduction in toto, the injection produced the following changes in the kidneys of the newborns: an increase in the cell size of convuluted tubules, narrowing of the tubular lumen and enhanced karyolysis. The changes indicated were more strongly pronounced in the newborns whose mothers had received kidney antigen-sensitized lymphoid cells before or in the early period of pregnancy, corresponding to the time of metanephros laying (days 10-12). The changes also depended on the doses of the cells injected. They were less pronounced if the mothers had received 15 million cells.
D000818:Animals; D003602:Cytotoxicity, Immunologic; D005260:Female; D007668:Kidney / Q000276:immunology* / Q000473:pathology; D007674:Kidney Diseases / Q000151:congenital / Q000276:immunology* / Q000473:pathology; D017710:Lymphocyte Transfusion; D008214:Lymphocytes / Q000276:immunology; D008431:Maternal-Fetal Exchange; D051379:Mice; D008808:Mice, Inbred CBA; D011247:Pregnancy; D014185:Transplantation, Isogeneic
Vliianie sensibilizirovannykh k pochechnym antigenam limfoidnykh kletok, vvedennykh mysham-samkam, na sostoianie pochek u ikh potomstva.