title: High pressure liquid chromatographic determination of antihistamine-adrenergic combination products.
abstract: Reverse phase high pressure liquid chromatography (HPLC) with ion-pairing is used for the determination of pseudoephedrine hydrochloride in combination with triprolidine hydrochloride or chlorpheniramine maleate in sirups and tablets. Sirups require a preliminary column chromatography cleanup step. Response is linear for pseudoephedrine hydrochloride (range of 0--20 micrograms), chlorpheniramine maleate (range of 0--1.3 micrograms), and triprolidine hydrochloride (range of 0--1.0 micrograms). Recoveries from synthetic formulations were 98.8--101.3% for pseudoephedrine hydrochloride, 100.0--101-2% for chlorpheniramine maleate, and 97.7--99.8% for triprolidine hydrochloride. The coefficient of variation for the method is less than 1%.
mesh_terms: D002744:Chlorpheniramine / Q000032:analysis*; D002851:Chromatography, High Pressure Liquid; D004338:Drug Combinations; D004809:Ephedrine / Q000032:analysis*; D008832:Microchemistry; D011725:Pyridines / Q000032:analysis*; D012996:Solutions / Q000032:analysis; D013607:Tablets / Q000032:analysis; D014311:Triprolidine / Q000032:analysis*
chemical_list: D004338:Drug Combinations; D011725:Pyridines; D012996:Solutions; D013607:Tablets; D014311:Triprolidine; D002744:Chlorpheniramine; D004809:Ephedrine