Relationship between fat-free weight and urinary 3-methythistidine excretion in man.
The relationship between body composition determined by densitometry and urinary 3-methylhistidine (3-Mehis) output was studied in 16 healthy men (range 23--52 yr) who consumed a self-selected meat-free diet for 3 days and collected a 24-hr urine sample on the third day. Urinary 3-Mehis and creatinine outputs were 225 +/- 8 mumoles/day (mean +/- SEM) and 1.6 +/- 0.1 g/day, respectively. Mean fat-free weight (FFW) was 61.5 kg (range 46.9--76.4 kg). FFW correlated more closely with urinary 3-Mehis excretion (r = 0.89, p < 0.001) than with urinary creatinine excretion (r = 0.67, p < 0.1). These results suggest that endogenous urinary 3-Mehis may be related to muscle weight, which is a major component of FFW.
D000273:Adipose Tissue / Q000033:anatomy & histology; D000328:Adult; D001823:Body Composition; D001835:Body Weight; D003404:Creatinine / Q000652:urine; D004044:Dietary Proteins / Q000008:administration & dosage; D006639:Histidine / Q000031:analogs & derivatives*; D006801:Humans; D008297:Male; D008460:Meat; D008762:Methylhistidines / Q000652:urine*; D008875:Middle Aged; D009132:Muscles / Q000033:anatomy & histology; D009929:Organ Size
D004044:Dietary Proteins; D008762:Methylhistidines; D006639:Histidine; D003404:Creatinine