[Comparison of treatments in senile osteoporosis: follow up for 12 months (author's transl)].
We randomly divided senile osteoporotic patients into 8 groups. Eleven patients of A-Group were treated daily with 900 mg of calcium and 50 mg of sodium fluoride and 50,000 units of vitamin D twice weekly. Fourteen patients of B-Group were treated daily with 900 mg of calcium and 50 mg of sodium fluoride. Twelve patients of C-Group were treated daily with 50 mg of sodium fluoride. Ten patients of D-Group were treated daily with 900 mg of calcium, 50 mg of sodium fluoride and 2 mg of estriol. Ten patients of E-Group were treated daily with 2 mg of estriol. Ten patients of F-Group were treated daily with 900 mg of calcium. Ten patients of G-Group were treated daily with 900 mg of calcium and 2 mg of estriol. The treatments were given for 12 months. Ten patients without treatment served as the non-treated control group. In each group, mineral contents were measured with Norland Bone Mineral Analyzer at the level of the distal third of the left radius and ulna before and after treatment. Mineral contents of ulnar bone in A-Group, of radial and ulnar bones in E-Group, F-Group, and G-Group increased with statistical significance after 12 months of the therapy. Mineral contents of radial and ulnar bones in C-Group and Nontreated Group decreased with statistical significance after 12 months. In laboratory examination, we observed no severe side-effect in our patients. But it was very interesting that the values of serum alkaline phosphatase in F-Group and G-Group decreased with statistical significance after 12 months of the therapies.
D000368:Aged; D000469:Alkaline Phosphatase / Q000627:therapeutic use; D001842:Bone and Bones / Q000032:analysis*; D002118:Calcium / Q000627:therapeutic use; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008903:Minerals / Q000032:analysis*; D010024:Osteoporosis / Q000188:drug therapy* / Q000378:metabolism; D010758:Phosphorus / Q000627:therapeutic use
D008903:Minerals; D010758:Phosphorus; D000469:Alkaline Phosphatase; D002118:Calcium