Prevalence and inheritance of factor XI (plasma thromboplastin antecedent) deficiency in cattle.
A survey of 169 Holstein-Friesian cattle showed 21 heterozygous for Factor XI activity having activities of .43 +/- .10 units per milliliter compared with the normal .99 +/- .32 units per milliliter. The frequency of the mutant gene was .06; the 95% confidence limits for the frequency of homozygotes in the population were .1 to .8%, and for heterozygotes the frequency was 7.0 to 16.0%. Test matings indicated this disorder is transmitted as an autosomal recessive gene.
D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D005173:Factor XI Deficiency / Q000175:diagnosis / Q000235:genetics / Q000473:pathology / Q000662:veterinary*; D005260:Female; D008297:Male; D010314:Partial Thromboplastin Time