title: The effect of cobra venom factor on alternative pathway hemolytic activity in mice.
abstract: The in vivo effect of cobra venom factor (CVF) on murine alternative complement pathway hemolytic activity was measured with a recently developed microassay. Four different dosage schedules of CVF were compared. Hemolytic titers were lowered to less than 5% of the baseline value by 6 hours after the first dose of CVF (62.5 - 200 U/kg), and remained low for 3-5 days, depending upon total dose, route and schedule of CVF administration. Titers at days 6-9 after initial CVF injection increased above baseline in animals given two doses of CVF separated by 48 hours.
mesh_terms: D000818:Animals; D003167:Complement Activation; D003170:Complement Pathway, Alternative; D004546:Elapid Venoms / Q000494:pharmacology*; D006461:Hemolysis; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D013997:Time Factors
chemical_list: D004546:Elapid Venoms