Microcalorimetric measurements of heat production in platelets of patients with prosthetic heart valves.
The heat production in resting platelets of 12 patients with prosthetic heart valves was found to be significantly decreased (p less than 0.005), P = 49 +/- 9 fW/cell. In a matched control group of eight patients with heart valve disease, the corresponding heat production value in resting platelets was P = 65 +/- 11 fW/cell. The present results indicate that the overall metabolic activity in platelets of patients with prosthetic heart valves is abnormally low.
D000328:Adult; D000368:Aged; D001792:Blood Platelets / Q000378:metabolism*; D002151:Calorimetry / Q000379:methods; D005260:Female; D006349:Heart Valve Diseases / Q000097:blood*; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006358:Hot Temperature; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy / Q000378:metabolism; D013923:Thromboembolism / Q000209:etiology