Evaluation of the 75Se-l-selenomethionine test for pancreatic disease. Studies on gel filtration.
Radioselenium-secretin-pancreozymin tests have been performed in 22 normal subjects and in 23 patients with pancreatic exocrine insufficiency. Each subject received an intravenous injection of 40-100 mu Ci 75Se-l-selenomethionine as a bolus which was followed by an intravenous infusion of secretin-CCK-PZ (1 CU/kg/h) for 2 h. Duodenal juice was collected from a double-lumen Lagerlöf tube and the 75Se radioactivity measured. Gel filtrations on Sephadex G-50 were performed from samples of duodenal juice. Total duodenal radioactivity in pancreatic insufficient patients was significantly lower than in normal subjects 60-120 min after the start of the examination. When regarding the individual values of each subject an important overlap of normal and pancreatic insufficient persons could be observed. No difference in the gel filtration pattern was demonstrable between the two groups. From these results the use of 75Se-l-selenomethionine for diagnostic purposes in pancreatic diseases cannot be recommended.
D002850:Chromatography, Gel; D004386:Duodenum / Q000378:metabolism; D005069:Evaluation Studies as Topic; D006801:Humans; D010182:Pancreatic Diseases / Q000175:diagnosis*; D012643:Selenium; D012645:Selenomethionine
D012645:Selenomethionine; D012643:Selenium