Matricin fibrils: isolation of the primary nuclear matrix polypeptides.
Matricin, a fundamental protein fibrillar structure of the eucaryotic cell nucleus, has been isolated from the rat liver nuclear matrix. The isolated matricin forms a diffuse reticulum of 30--50 A fibrils and consists predominantly of three primary polypeptide fractions with apparent molecular weights of 62,000, 66,000 and 70,000. Aside from a major role in nuclear structure, matricin may provide an important functional milieu for such fundamental nuclear processes as replication, transcription and the processing and transport of RNA.
D000818:Animals; D002467:Cell Nucleus / Q000502:physiology / Q000648:ultrastructure*; D002868:Chromosomal Proteins, Non-Histone / Q000302:isolation & purification* / Q000502:physiology; D008099:Liver / Q000648:ultrastructure; D008970:Molecular Weight; D034521:Nuclear Matrix-Associated Proteins; D010455:Peptides / Q000302:isolation & purification*; D051381:Rats
D002868:Chromosomal Proteins, Non-Histone; D034521:Nuclear Matrix-Associated Proteins; D010455:Peptides; C025914:matricin protein, rat