[State of the microcirculation following total blood replacement with a model perfluorotributylamine-based blood substitute in rats].
Microcirculation was studied in experiments on rats whose blood had been completely replaced by perfluorotributylamin emulsion. After blood replacement the microcirculatory channel was actively perfused with the blood substitute. It was shown that the emulsion circulation rate exceeded the initial rate of the blood flow, that high level of nutritive vessels perfusion was maintained and the physiological parameters of reactivity and functional motility of microvessels remained unchanged. It is suggested that under these circumstances there exist favourable conditions for transcapillary exchange. Active circulation of the blood substitute in the vascular channel lasted 1.5--2.5 h.
D000818:Animals; D001783:Blood Flow Velocity; D001794:Blood Pressure / Q000187:drug effects; D002082:Butylamines / Q000494:pharmacology*; D002199:Capillary Permeability / Q000187:drug effects; D004837:Epinephrine / Q000494:pharmacology; D005466:Fluorocarbons / Q000494:pharmacology*; D008833:Microcirculation / Q000187:drug effects*; D010952:Plasma Substitutes / Q000494:pharmacology*; D051381:Rats
D002082:Butylamines; D005466:Fluorocarbons; D010952:Plasma Substitutes; C008807:perfluorotributylamine; D004837:Epinephrine
Sostoianie mikrotsirkuliatsii pri polnom zameshchenii krovi model'iu krovezamenitelia na osnove perftortributilamina u krys.