Polydimethylsiloxane pellets for sustained delivery of morphine in mice.
A new dosage form was designed whereby a polymeric silicone elastomer provided sustained delivery of morphine to mice over 11 days. These pellets, which can be made easily and inexpensively with a standard tablet mold, gradually released morphine sulfate into the implanted mice. Maximal morphine-induced physical dependence, measured by jumping during naloxone-induced withdrawal, was observed 3--5 days after implantation. At this time, slightly less than 50% of the morphine sulfate had been released. Drug release continued through Day 11 and was accompanied by a physical dependence of decreased magnitude compared to that observed on Day 3 or 5.
D000818:Animals; D003692:Delayed-Action Preparations; D004129:Dimethylpolysiloxanes; D004343:Drug Implants; D006207:Half-Life; D008297:Male; D051379:Mice; D009020:Morphine / Q000008:administration & dosage* / Q000378:metabolism; D009043:Motor Activity / Q000187:drug effects; D012828:Silicones; D013997:Time Factors
D003692:Delayed-Action Preparations; D004129:Dimethylpolysiloxanes; D004343:Drug Implants; D012828:Silicones; D009020:Morphine