A simple test for detection of specific and unspecific immunological reactions in cancer.
The surface fixation method has been found to be a reliable procedure for detection of antibodies of retrogenetic origin in cancer serum and also for specific immunoglobulins stimulated by antigens sinthezized in malignant cells. An insoluble extract obtained from human placentas has been used for detection of retrogenectic antibodies and with soluble substances obtained from the urine of patients it has been possible to detect what seem to be specific antibodies in retinoblastoma, Hodgkin, sarcoma and carcinoma. However with a urine extract from leukemia patients the positive reactions occur with leukemia serum from leukemia as well as with the related lymphoma and myeloma. Circulating tumor associated antigens can be detected in mixtures of an anti-fetal serum with cancer serum, but cross-reactions have been found in similar tests with pregnant women's serum.
D000912:Antibodies, Neoplasm / Q000032:analysis*; D000937:Antigen-Antibody Reactions; D000954:Antigens, Surface / Q000032:analysis / Q000276:immunology*; D005260:Female; D006801:Humans; D007841:Latex Fixation Tests / Q000379:methods; D009369:Neoplasms / Q000276:immunology*; D010455:Peptides; D011247:Pregnancy
D000912:Antibodies, Neoplasm; D000954:Antigens, Surface; D010455:Peptides