Physiological flow model for drug elimination interactions in the rat.
Drug elimination interactions in the rat are modelled based on physiological blood flow rates and organ weights. A previous model has been substantially improved by the addition of a compartment representing the skin and the interactions are computed using Michaelis-Menten kinetics for competitive inhibition in the shared pathways. Furthermore, the results of repetitive dosing may also be simulated. The programs, which are extensively annotated and user oriented, are illustrated on the results of an acute warfarin--BSP interaction experiment in rats.
D000818:Animals; D003201:Computers; D004338:Drug Combinations; D004347:Drug Interactions; D007700:Kinetics; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D004364:Pharmaceutical Preparations / Q000097:blood / Q000378:metabolism*; D051381:Rats; D012867:Skin / Q000378:metabolism; D013448:Sulfobromophthalein / Q000378:metabolism; D014018:Tissue Distribution; D014859:Warfarin / Q000378:metabolism
D004338:Drug Combinations; D004364:Pharmaceutical Preparations; D013448:Sulfobromophthalein; D014859:Warfarin