Fiberoptic colonoscopic study of experimental chemical colitis.
Acute diffuse chemical colitis was produced in rats with a high degree of reproducibility by the intracolonic administration of 10% acetic acid. The evolution and progression of this colitis was followed by performing serial fiberoptic colonoscopy using a needlescope and biopsy. Hyperemia appeared at 10 hours and ulcerations appeared at 24 hours in acetic acid-treated animals. After 3 days, the ulcers were covered with a yellowish exudate. At 8 weeks there was endoscopic and histologic healing of the lesions. No changes occurred in the saline-treated animals. Concomitant topical applications of epsilon-aminocaproic acid protected against acetic acid-induced injury.
D000614:Aminocaproates / Q000494:pharmacology / Q000627:therapeutic use; D000818:Animals; D001707:Biopsy, Needle; D003092:Colitis / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D003106:Colon / Q000187:drug effects; D004195:Disease Models, Animal; D004724:Endoscopy; D005336:Fiber Optic Technology; D008297:Male; D011351:Proctoscopy; D051381:Rats
D000614:Aminocaproates