title: Left atrial thrombus despite anticoagulant therapy in a patient with a mitral valve prosthesis.
abstract: Massive left atrial thrombus (MLAT) developed in a patient with porcine heterograft mitral valve, left atrial dilatation, and atrial fibrillation, despite anticoagulant therapy with warfarin sodium (Coumadin). The thrombus obstructed the mitral valve orifice, leading to acute myocardial infarction, pulmonary edema, and death due to cardiogenic shock.
mesh_terms: D000925:Anticoagulants / Q000627:therapeutic use*; D001281:Atrial Fibrillation / Q000150:complications; D006325:Heart Atria; D006331:Heart Diseases / Q000209:etiology*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D009203:Myocardial Infarction / Q000209:etiology; D011654:Pulmonary Edema / Q000209:etiology; D013927:Thrombosis / Q000209:etiology*
chemical_list: D000925:Anticoagulants