In vitro peripheral airway constriction to honey bee venom in cat.
Isolated  lung parenchymal strips (peripheral airways) of cats responded to histamine, carbachol, 5-HT, bradykinin and honey bee-venom with concentration-dependent contractions. Atropine, mepyramine and methysergide inhibited or reversed contractions to carbachol, histamine and 5-HT respectively. Atropine, methysergide and indomethacin did not influence contractions to honey bee venom. High doses of mepyramine (H1-antagonist) inhibited or reversed the bee venom-induced contractions. These observations suggest that honey bee venom may be constricting cat peripheral airways by releasing endogenous histamine from the lung mast cells. Aceylcholine,  5-HY and prostaglandins appear to play little or no important role in the peripheral airway constrictions to honey bee venom in cat.
D000818:Animals; D001514:Bee Venoms / Q000494:pharmacology*; D001920:Bradykinin / Q000494:pharmacology; D002217:Carbachol / Q000494:pharmacology; D002415:Cats; D003251:Constriction, Pathologic; D005260:Female; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects*; D008297:Male; D012701:Serotonin / Q000494:pharmacology
D001514:Bee Venoms; D012701:Serotonin; D006632:Histamine; D002217:Carbachol; D001920:Bradykinin