title: Diversion of duodenal contents: its effect on the production of experimental gastric cancer.
abstract: Diversion of duodenal contents after gastroenterostomy and vagotomy did not protect 240 laboratory rats from increased risk of gastric carcinoma. They were divided into three groups of 80: group 1 received 0.9 mg of 3-methylcholanthrene injected submucosally into the gastric antrum; groups 2 and 3 had bilateral truncal vagotomy and gastroenterostomy, with carcinogen injected into the gastric submucosa near the anastomosis; group 3 also had total duodenoenteric diversion. Blind histopathologic examination of surviving rats during necropsy eight months later disclosed that cancer had developed in six of 60 (10%) group 1 rats, in 23 of 71 (33%) group 2 rats, and in seven of 27 (22%) group 3 rats. Compared with group 1, groups 2 and 3 had an increased incidence of gastric cancer but did not differ from one another in this regard.
mesh_terms: D000230:Adenocarcinoma / Q000453:epidemiology / Q000209:etiology*; D000818:Animals; D004386:Duodenum / Q000378:metabolism*; D005753:Gastric Mucosa / Q000473:pathology; D005763:Gastroenterostomy / Q000009:adverse effects*; D008297:Male; D008679:Metaplasia; D008748:Methylcholanthrene; D009374:Neoplasms, Experimental / Q000453:epidemiology / Q000209:etiology; D051381:Rats; D012306:Risk; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000209:etiology*; D014628:Vagotomy / Q000009:adverse effects*
chemical_list: D008748:Methylcholanthrene