Influence of dietary lipid on the metabolism of hexobarbital by the isolated, perfused rat liver.
Isolated livers from rats fed a diet containing corn oil (10% W/W) perfused with a blood-free, modified Krebs-Henseleit solution cleared hexobarbital at a rate significantly faster than livers from rats fed a similar diet devoid of corn oil. The half-lives of hexobarbital in these experiments were 22.4 +/- 1.8 min for livers from rats fed corn oil and 30.0 +/- 1.2 min for those from rats fed the fat-free diet. This represented a metabolic rate of 54 microgram hexobarbital/g liver/min in fat-fed animals and 36 microgram hexobarbital/g liver/min in those fed a rat-free diet.
D000818:Animals; D004041:Dietary Fats / Q000494:pharmacology*; D006207:Half-Life; D006591:Hexobarbital / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D051381:Rats
D004041:Dietary Fats; D006591:Hexobarbital; D010088:Oxidoreductases