IgA and temperature dependent IgG complex formation in a patient with Waldenström's hypergammaglobulinaemic purpura.
We describe a patient with hypergammaglobulinaemic purpura and show that the serum contains IgG and IgA immune complexes sedimenting between IgM and IgG on ultracentrifugation. The complexes containing IgG were markedly temperature dependent. A drop in temperature from 37 degrees C to 28 degrees C gave a seventeen-fold increase in the quantity of these complexes. This temperature dependency may be an important factor in localizing the major pathological manifestation of this disease to the skin.
D000328:Adult; D000936:Antigen-Antibody Complex; D005260:Female; D006358:Hot Temperature; D006801:Humans; D007070:Immunoglobulin A / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D011694:Purpura, Hyperglobulinemic / Q000276:immunology*; D014461:Ultracentrifugation
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G