Effect of prolonged treatment of norethisterone (a progestogen-only contraceptive) on the thyro-follicular activity of rat.
Treatment of norethisterone (a synthetic progestin-only contraceptive) with a daily dosage of 0.5 mg/rat, consecutively for 75 days increased gland weight and caused hyperthyroidism in the albino rat. This was evident from gravimetric and histological studies. The findings suggest that even  progestogen-only contraceptives have untoward effects upon thyroid gland function in the albino rat.
D000818:Animals; D004848:Epithelium / Q000187:drug effects; D005260:Female; D006984:Hypertrophy / Q000139:chemically induced; D008938:Mitosis / Q000187:drug effects; D009640:Norethindrone / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013961:Thyroid Gland / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects*
D009640:Norethindrone