Common bile duct pressure during enflurane anesthesia. Effects of morphine and subsequent naloxone.
In ten otherwise healthy patients undergoing cholecystectomy and cholangiography, morphine sulfate, in a dose of 2.5 mg/70 kg body weight, significantly elevated common bile duct pressure, as measured by water manometry, two and five minutes after intravenous injection. There was no added effect from an additional 7.5 mg/70 kg, measured two and five minutes after injection. Naloxone hydrochloride, in a dose of 1.0 mg/70 kg body weight, quickly reversed the increase in pressure caused by the morphine. Radiographic contrast material passed into the duodenum in every patient after administration of naloxone.
D000328:Adult; D000777:Anesthetics; D001660:Biliary Tract Diseases / Q000000981:diagnostic imaging / Q000601:surgery; D002758:Cholangiography; D002763:Cholecystectomy; D003135:Common Bile Duct / Q000187:drug effects*; D004737:Enflurane; D005260:Female; D006801:Humans; D008297:Male; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology*; D011312:Pressure
D000777:Anesthetics; D009270:Naloxone; D009020:Morphine; D004737:Enflurane