In vivo autoradiography and planimetry of epidermis in psoriatics under PUVA-therapy.
The effects of oral 8-methoxypsoralen-photochemotherapy (PUVA)-therapy) on involved epidermis of nine psoriatics and on normal skin of four control subjects was investigated by means of in vivo autoradiography and planimetry. Under PUVA-therapy there is a significant decrease of 3H-TdR labeled cells per epidermal cross-sectional surface, per length of basal membrane and per length of epidermal surface. There is also a significant decrease of epidermal thickness. In the initial phase of PUVA-therapy the decrease of 3H-TdR labeled cells is the most pronounced. The reduction of epidermal thickness is less than the decrease of 3H-TdR labeled cells.
D000328:Adult; D001345:Autoradiography; D004817:Epidermis / Q000187:drug effects / Q000473:pathology; D006801:Humans; D008297:Male; D008730:Methoxsalen / Q000494:pharmacology*; D008875:Middle Aged; D010778:Photochemotherapy; D011565:Psoriasis / Q000188:drug therapy* / Q000473:pathology; D012867:Skin / Q000187:drug effects*
D008730:Methoxsalen