Regional myocardial protection: use of a new method to compare cold potassium cardioplegia with hypothermic coronary perfusion.
A new canine model was developed to compare two cardiplegic agents using each heart as its own control. Paired piezoelectric crystals were implanted into the left anterior descending and circumflex regions. The percentage of shortening (systolic shortening/end-diastolic segment length X 100) was assessed in each region on right-heart bypass over a range of cardiac outputs. Durng 100 minutes of ischemic arrest the left anterior descending and circumflex regions were perfused separately every 20 minutes with either cold buffered saline or cold KCl cardioplegia solutions. After recovery, the percentage of shortening after ischemic arrest was determined. The percentage of shortening in the region protected by KCl was unchanged (12.5 +/- 5.0 to 13.0 +/- 4.6%) after arrest, but was markedly decreased in the buffered saline region (11.3 +/- 5.9 to 3.2 +/- 4.9%) (p < 0.001, n = 6). This model should facilitate the comparison of two cardioplegic solutions.
D000818:Animals; D002302:Cardiac Output; D006348:Cardiac Surgical Procedures; D003080:Cold Temperature; D003326:Coronary Circulation; D003331:Coronary Vessels; D003971:Diastole; D004285:Dogs; D005260:Female; D006324:Heart Arrest, Induced; D007036:Hypothermia, Induced; D008297:Male; D008863:Microspheres; D009206:Myocardium; D010477:Perfusion; D011188:Potassium
D011188:Potassium