Studies on antihyperlipidemic agents. I. Synthesis and hypolipidemic activities of phenoxyphenyl alkanoic acid derivatives.
The alkanoic acids containing phenoxyphenyl moiety at omega-position were prepared and tested for hypolipidemic property. Some of the compounds showed hypoglycemic activity besides hypolipidemic one. Further study on the selected compound, 3-[4-(4-chlorophenoxy)benzoyl] propionic acid (8) revealed that it increased insulin sensitivity of adipose tissue of obese and diabetic mice (KKAY). The structure-activity relationship was discussed briefly.
D000818:Animals; D002264:Carboxylic Acids / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000494:pharmacology; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents / Q000138:chemical synthesis*; D008297:Male; D051379:Mice; D051381:Rats; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D002264:Carboxylic Acids; D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; D014280:Triglycerides; D002784:Cholesterol; D002994:Clofibrate