Nitrogen retention during late gestation in the rat in response to marginal zinc intake.
This study was conducted to characterize nitrogen retention in response to marginal dietary zinc during gestation. Long-Evans rats were randomly assigned to one of two dietary groups on day 1 of gestation. The dams were fed a basal diet supplemented with either restricted or control levels of zinc. Feces and urine were collected for 24 h on day 20 of pregnancy, and their nitrogen and zinc contents were determined. Urinary and fecal nitrogen excretions were similar for zinc-restricted and control dams, whereas fecal zinc excretions were depressed by feeding the zinc-restricted diet. Mean zinc and nitrogen retentions were negative for the zinc-restricted and positive for the control groups. Multiple stepwise regression analysis showed that nitrogen retention on day 20 depended on both dietary nitrogen and zinc intakes. Zinc-restricted offspring weighed 12% less and the maternal plasma zinc concentrations were reduced by 66% when compared with the control group values on day 22. Marginal dietary zinc and the associated anorexia limited fetal growth without causing excessive nitrogen excretion or severe weight loss.
D000818:Animals; D001724:Birth Weight; D004032:Diet; D005243:Feces / Q000032:analysis; D005260:Female; D005317:Fetal Growth Retardation / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D009584:Nitrogen / Q000032:analysis / Q000378:metabolism* / Q000652:urine; D011247:Pregnancy; D051381:Rats; D013997:Time Factors; D015032:Zinc / Q000008:administration & dosage / Q000172:deficiency*
D015032:Zinc; D009584:Nitrogen