title: Regulatory issues concerning AETT and 6-MC.
abstract: Acetylethyltetramethyltetralin, a widely used synthetic fragance material, was found to cause neurotoxic effects in animals. 6-Methylcoumarin, another fragance material, was determined to be a photocontact allergen. Insufficient information on their usage, consumer exposure and likely hazard to human health under conditions of use impair regulatory decisions. FDA's ability to protect consumers against a health hazard is greatly influenced by the availability of such data.
mesh_terms: D000818:Animals; D003358:Cosmetics / Q000009:adverse effects*; D003374:Coumarins / Q000009:adverse effects*; D003876:Dermatitis, Atopic / Q000139:chemically induced; D006801:Humans; D007880:Legislation, Drug; D009281:Naphthalenes / Q000009:adverse effects*; D009498:Neurotoxins; D010787:Photosensitivity Disorders / Q000139:chemically induced; D013764:Tetrahydronaphthalenes / Q000009:adverse effects*; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D003358:Cosmetics; D003374:Coumarins; D009281:Naphthalenes; D009498:Neurotoxins; D013764:Tetrahydronaphthalenes; C023054:versalide; C018096:6-methylcoumarin