The effect of pyrrolizidine alkaloids (Senecio vulgaris) on the liver mixed-funcion oxidase system.
A model system to detect the toxicity of pyrrolizidine alkaloids (PAs) was explored. Using the liver S-10 fraction, the effect of PAs on aniline hydroxylase and aminopyrine N-demethylase was examined. PAs were toxic to the aminopyrine N-demethylase enzyme system while exerting no toxicity on the aniline hydroxylase enzyme system.
D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000815:Aniline Hydroxylase / Q000378:metabolism; D000818:Animals; D066298:In Vitro Techniques; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects* / Q000201:enzymology; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D011763:Pyrrolizidine Alkaloids / Q000494:pharmacology*; D051381:Rats
D011763:Pyrrolizidine Alkaloids; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D000815:Aniline Hydroxylase; D000633:Aminopyrine N-Demethylase