Interaction of rifampin and chlorpropamide.
A 62-year-old man who had been taking 250 mg of chlorpropamide daily for several years received rifampin concomitantly and had a subsequent increased dosing requirement of chlorpropamide. When rifampin was discontinued several months later, the serum chlorpropamide concentration rose dramatically.
D001786:Blood Glucose / Q000032:analysis; D002747:Chlorpropamide / Q000008:administration & dosage / Q000097:blood* / Q000627:therapeutic use; D003920:Diabetes Mellitus / Q000097:blood; D004347:Drug Interactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use
D001786:Blood Glucose; D012293:Rifampin; D002747:Chlorpropamide