C-Glucuronidation of the acetylenic moiety of ethchlorvynol in the rabbit.
An acetylenic C-glucuronide of the sedative-hypnotic drug ethchlorvynol was isolated from rabbit urine as the major metabolite. The C-glucuronide represents a novel metabolic pathway for acetylenes and is a rare example of the formation of a carbon-glucuronide bond in mammalian systems.
D000114:Acetylene; D000818:Animals; D002250:Carbon Radioisotopes; D004984:Ethchlorvynol / Q000031:analogs & derivatives* / Q000378:metabolism* / Q000652:urine; D005966:Glucuronidase; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011817:Rabbits; D013055:Spectrophotometry, Infrared
D002250:Carbon Radioisotopes; C025950:ethchlorvynol glucuronide; D004984:Ethchlorvynol; D005966:Glucuronidase; D000114:Acetylene