Tumoricidal response induced by cytosine arabinoside after plasma perfusion over protein A.
In dogs with spontaneous mammary adenocarcinomas, a single nontoxic infusion of cytosine arabinoside after extracorporeal perfusion of plasms over immobilized protein A resulted in a necrotizing response rapid in onset and specific for tumorous tissue. Gross tumoricidal reactions 12 hours after this combined treatment exceeded the algebraic sum of responses to cytosine arabinoside and protein A perfusion treatments alone in the same dogs, implying a synergistic effect between the two. The magnitude, rapidity, and specificity of the tumoricidal response after the combined treatment suggests that it may be an effective chemimmunotherapeutic approach to breast adenocarcinoma.
D000230:Adenocarcinoma / Q000628:therapy*; D000818:Animals; D000912:Antibodies, Neoplasm; D003561:Cytarabine / Q000008:administration & dosage* / Q000627:therapeutic use; D004285:Dogs; D005260:Female; D007167:Immunotherapy; D008325:Mammary Neoplasms, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D009336:Necrosis; D010477:Perfusion; D013205:Staphylococcal Protein A / Q000276:immunology / Q000627:therapeutic use*; D013211:Staphylococcus aureus / Q000276:immunology
D000912:Antibodies, Neoplasm; D013205:Staphylococcal Protein A; D003561:Cytarabine