title: Side-effects of prosthetic materials on the human body.
abstract: The authors report 6 patients (7 joints) in whom inflammation, dermal necrosis, dermatitis or fistula formation was attributed to the materials commonly used for joint endoprostheses. Histological appearances and chemical analyses of the involved tissues are presented, together with a discussion of the possible mechanism and methods of diagnosis and treatment.
mesh_terms: D000328:Adult; D000368:Aged; D002858:Chromium Alloys / Q000009:adverse effects / Q000032:analysis; D004551:Elbow Joint / Q000601:surgery; D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects; D006801:Humans; D007592:Joint Diseases / Q000209:etiology*; D007595:Joint Prosthesis / Q000009:adverse effects*; D007720:Knee Prosthesis / Q000009:adverse effects; D008297:Male; D008670:Metals / Q000009:adverse effects*; D008875:Middle Aged; D009532:Nickel / Q000009:adverse effects / Q000032:analysis; D011095:Polyethylenes / Q000009:adverse effects; D012882:Skin Tests; D013582:Synovial Fluid / Q000032:analysis
chemical_list: D002858:Chromium Alloys; D008670:Metals; D011095:Polyethylenes; D009532:Nickel