D-penicillamine-induced bronchial spasm.
Although d-penicillamine has a wide range of benefits in many clinical conditions, various side effects have also been reported and preclude its further use in certain patients. In this case, d-penicillamine-induced reversible airway obstruction developed, despite the "go slow--go low" regimen as suggested to reduce the incidence of its side effects. The patient had bronchial spasm and angioedema shortly after the dose was increased from 500 mg to 750 mg/day. Persistent vigilance is necessary to avoid potentially fatal reactions.
D000293:Adolescent; D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001986:Bronchial Spasm / Q000139:chemically induced*; D004487:Edema / Q000139:chemically induced; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010396:Penicillamine / Q000009:adverse effects*
D010396:Penicillamine