title: Parathyroid hormone in chronic renal failure: studies with two different parathyroid hormone radioimmunoassays.
abstract: Two assays for immunoreactive parathyroid hormone (iPTH) with different specificities were used to evaluate the role of iPTH measurement in patients with chronic renal failure (CRF). One measured largely C-terminal iPTH fragments, the other largely intact iPTH. In untreated CRF, the log iPRH for each assay was significantly correlated with the reciprocal of the creatinine clearance (CCr). C-terminal iPTH was elevated at relatively high CCr values, but intact iPTH was not elevated until later in the progression of CRF. In hemodialysis patients treated with 25-hydroxyvitamin D3, intct iPTH correlated better than C-terminal iPTH with clinical improvement. These two assays used together were more helpful in evaluation of CRF patients than either assay alone.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000097:blood; D002417:Cattle; D003404:Creatinine / Q000097:blood; D003429:Cross Reactions; D006801:Humans; D007676:Kidney Failure, Chronic / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000032:analysis / Q000276:immunology / Q000378:metabolism*; D011863:Radioimmunoassay
chemical_list: D010281:Parathyroid Hormone; D003404:Creatinine; D002118:Calcium