[Allergenic properties of a series of N-phenyl N'alcoyl paraphenylenediamines].
The well known high allergenic potential of N-phenyl N'-isopropyl paraphenylenediamine (I.P.P.D.), as well as that of N-phenyl N'-1,3 dimethylbutyl paraphenylenediamine, though allegedly milder, prompted us to investigate the allergenicity of a series of N-phenyl N'-alcoyl paraphenylenediamines. We chose an existing technical grade series with substituents ranging from methyl to dodecyl. The results, on laboratory animals (Kligman and Magnusson's maximalization test), and on I.P.P.D.-sensitized humans (ROC Neodermotest, 48th hour) indicate a group sensitization with nearly systematic cross-reactions.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D055598:Chemical Phenomena; D002621:Chemistry; D002849:Chromatography, Gas; D003877:Dermatitis, Contact / Q000209:etiology*; D006168:Guinea Pigs; D006801:Humans; D010328:Patch Tests; D010655:Phenylenediamines / Q000009:adverse effects / Q000276:immunology*; D013055:Spectrophotometry, Infrared
D000941:Antigens; D010655:Phenylenediamines
Etude allergologique concernant une série de N-phényl-N'-alcoyl paraphénylène diamines.