Permeability characteristics of muscle membrane.
Unidirectional flux rates of saturated fatty acids, saturated alcohols, and bile acids were measured in an intact rat diaphragm preparation. The logarithm of the permeability coefficients for fatty acids containing from five to ten carbon atoms was a linear function of the number of carbon atoms in the fatty acid chain. Incremental free energies of solution were +336 cal x mol-1 for the addition of a hydroxyl group and -258 cal x mol(-1) for the addition of a methylene group. These incremental free energies were similar to those obtained by other investigators in other animal tissues, and our data suggest a structural similarity between membranes in different tissues and in different species. The muscle membrane exhibited anomalously high permeabilities for fatty acids containing less than five carbon atoms. Since muscle lacks tight junctions, this result suggest that small non-electrolytes traverse polar regions or aqueous pores within the cellular membrane.
D000438:Alcohols / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000378:metabolism; D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism; D002463:Cell Membrane Permeability; D003964:Diaphragm / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D007700:Kinetics; D008297:Male; D008433:Mathematics; D009132:Muscles / Q000378:metabolism*; D051381:Rats; D013329:Structure-Activity Relationship
D000438:Alcohols; D001647:Bile Acids and Salts; D005230:Fatty Acids, Nonesterified