Bone-seeking properties of Tc-99m carbonyl diphosphonic acid, dihydroxy-methylene diphosphonic acid and monohydroxy-methylene phosphoinic acid: concise communication.
Carbonyl diphosphonic acid, dihydroxy-methylene diphosphonic acid and monohydroxy-methylene diphosphonic acid were synthesized and labeled with Tc-99m. Their chemical structures were confirmed and their bone-seeking relationships were compared with those of Tc-99m MDP in experimental animals. MKonohydroxy-methylene diphosphonic acid was found to have higher bone affinity and faster blood clearance than MDP, whereas carabonyl diphosphonic acid and dihydroxy-methylene diphosphonic acid demonstrated lower bone affinity and slower blood clearance than MDP.
D000818:Animals; D001842:Bone and Bones / Q000000981:diagnostic imaging* / Q000378:metabolism; D002614:Chelating Agents; D055598:Chemical Phenomena; D002621:Chemistry; D004164:Diphosphonates / Q000378:metabolism; D007553:Isotope Labeling; D008297:Male; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D051381:Rats; D013667:Technetium / Q000378:metabolism; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives*; D013997:Time Factors; D014018:Tissue Distribution
D002614:Chelating Agents; D004164:Diphosphonates; D015609:Organotechnetium Compounds; C026181:technetium Tc 99m carbonyl diphosphonic acid; C026182:technetium Tc 99m dihydroxymethylene diphosphonic acid; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D013667:Technetium; D013669:Technetium Tc 99m Medronate