Extramedullary hematopoiesis presenting as mediastinal tumor.
An autopsy revealed extramedullary hematopoietic foci scattered along the thoracic vertebrae and between the ribs in a patient who died of lung cancer. One of them formed a tumor-like mass adhering to the 10th vertebra, and measured 8X6X2 cm. The cellular components included erythrocytic, granulocytic and megakaryocytic series at various stages of maturation as well as abundant iron-pigmented histiocytes. The patient also suffered from chronic hemolytic anemia and secondary hemochromatosis. The intimate relationship of the intrathoracic tumor-like masses of extramedullary hematopoietic tissue with chronic hemolytic anemia is briefly reviewed.
D000741:Anemia, Aplastic / Q000209:etiology; D002828:Choristoma / Q000473:pathology*; D006410:Hematopoiesis; D006432:Hemochromatosis / Q000209:etiology; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008479:Mediastinal Neoplasms / Q000150:complications / Q000473:pathology*; D008875:Middle Aged