Dietary folic acid and the activity of brain cholinergic and gamma-aminobutyric acid (GABA) enzymes.
Charles River CD male rats were randomly divided into 3 groups of five each and placed on folate deficient, folate excess, and control diets respectively. glutamate decarboxylase GAD gamma-amino-butyrate aminotransferase (GABA-T), choline acetltransferase (ChAc), and acetylcholinesterase (AChE) were assayed in the rat brains after 6 weeks of dietary treatment. Neither folate deficiency nor folate supplementation influenced the enzymes associated with GABA and acetylcholine metabolism.
D000110:Acetylcholinesterase / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002262:Carboxy-Lyases / Q000378:metabolism*; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004032:Diet; D005492:Folic Acid / Q000097:blood / Q000494:pharmacology*; D005494:Folic Acid Deficiency / Q000201:enzymology; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D008297:Male; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D005492:Folic Acid; D002795:Choline O-Acetyltransferase; D000110:Acetylcholinesterase; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase