Sodium-dependent interaction of benzamides with dopamine receptors.
Sulpiride and other benzamide (BM)-displacing activity on [3H]-spiroperidol ([3H]SPIR) binding by rat striatal dopaminergic receptors was found to be uniquely sodium-dependent, while classical neuroleptic (NL) activity was not influenced by NaCl. These results suggest the existence of at least two populations of striatal dopaminergic receptors, sodium-dependent and sodium-independent, through which BM and NL respectively interact.
D000818:Animals; D001549:Benzamides / Q000378:metabolism / Q000494:pharmacology*; D001667:Binding, Competitive / Q000187:drug effects; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000378:metabolism; D012964:Sodium / Q000494:pharmacology*; D013134:Spiperone / Q000378:metabolism
D001549:Benzamides; D011954:Receptors, Dopamine; D013134:Spiperone; D012964:Sodium