title: Irradiation injury to large arteries.
abstract: Four cases of irradiation injury to large arteries are presented and the literature is reviewed. Three patterns of injury have emerged. 1. Intimal damage resulting in mural thrombosis presenting within 5 years of irradiation. 2. Fibrotic occlusion presenting within 10 years of injury. 3. A predisposition to the development of atheroma together with periarterial fibrosis associated with a latent interval of 20 or more years. The treatment of choice is a bypass procedure of the arterial lesion.
mesh_terms: D000328:Adult; D001157:Arterial Occlusive Diseases / Q000209:etiology; D001161:Arteriosclerosis / Q000209:etiology; D001366:Axillary Artery / Q000528:radiation effects*; D005260:Female; D006801:Humans; D007083:Iliac Artery / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D011832:Radiation Injuries / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects*; D013348:Subclavian Artery / Q000528:radiation effects*; D013927:Thrombosis / Q000209:etiology; D013997:Time Factors