Problems and pitfalls in ototoxicity testing.
A local anaesthetic drug under development, intended for use in ear surgery, was tested with regard to adverse, ototoxic effects. Inner ear damage was not obvious. However, in the guinea pig a massive formation of new bone occurred in the middle ear (bulla tympanica) within 5 weeks after a single local administration of the drug.
D000779:Anesthetics, Local / Q000009:adverse effects*; D000818:Animals; D004353:Drug Evaluation, Preclinical; D007758:Ear, Inner / Q000187:drug effects* / Q000473:pathology; D004432:Ear, Middle / Q000187:drug effects* / Q000473:pathology; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects; D013997:Time Factors
D000779:Anesthetics, Local