[Tienilic acid-induced hepatitis associated with liver/kidney microsomal antibody (author's transl)].
Six patients developed acute, subacute or chronic hepatitis after taking tielinic acid, a new diuretic used in the treatment of hypertension. Two died of acute liver failure. The condition was characterized by marked increase in serum transaminases, parenchymal necrosis and portal and/or lobular inflammatory fibrosis. In addition, the serum of all patients contained high titers of a liver/kidney microsomal antibody, which disappeared either after tienilic acid was discontinued or after prednisolone was introduced. The study shows that tienilic acid may be responsible for acute or chronic hepatitis and suggests that a liver/kidney microsomal antibody could be a sero-immunological marker of drug-induced liver disease.
D000208:Acute Disease; D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology*; D002908:Chronic Disease; D004721:Endoplasmic Reticulum / Q000276:immunology*; D005260:Female; D006016:Glycolates / Q000009:adverse effects*; D006801:Humans; D007668:Kidney / Q000276:immunology; D008099:Liver / Q000473:pathology; D008297:Male; D008861:Microsomes / Q000276:immunology; D008862:Microsomes, Liver / Q000276:immunology; D008875:Middle Aged; D013989:Ticrynafen / Q000009:adverse effects*; D000637:Transaminases / Q000097:blood
D001323:Autoantibodies; D006016:Glycolates; D000637:Transaminases; D013989:Ticrynafen
Atteintes hépatiques dues à l'acide tiénilique. Six observations avec présence d'anticorps antireticulum endoplasmique.