[Rare liver damage caused by an antihypertensive and anti-arrhythmic agents].
It is reported on lesions of the liver parenchyma after the application of dihydralazin and detajmium bitartrate with description of the clinical and morphological findings. By means of the morphological findings got in liver biopsy a clinically supposed acute virus hepatitis could be excluded. After the application of dihydralazin group cell necroses and an inflammation of the periportal fields, after detajmium bitartrate a typical intrahepatic cholestasis was in the front. The knowledge of medicamentous side-effects may avoid diagnostic and therapeutic errors in the individual case.
D000328:Adult; D000404:Ajmaline / Q000009:adverse effects*; D001706:Biopsy; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced; D004078:Dihydralazine / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006830:Hydralazine / Q000031:analogs & derivatives*; D008099:Liver / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced
D000404:Ajmaline; D006830:Hydralazine; D004078:Dihydralazine
Seltene Leberschäden durch Antihypertensiva und Antiarrhythmika.