title: Studies on transitional cells. I. Kinetic changes in rat bone marrow during hypoxia and rebound.
abstract: Kinetic changes have been studied in the transitional cells of the marrow in normal, hypoxic (0.5 atm) and rebound rats. Suspensions of marrow cells were incubated with tritiated thymidine for 1 hour, and the percentage of labelled transitionals of all sizes, as well as of large transitionals, was couinted in radioautographs. From a normal labelling index of 55.4% +/- 6.0089 there is an initial fall after 1 day of hypoxia, followed by a significant rise to 69.233 +/- 2.8263% on day 3, when erythropoiesis is at its peak. This is followed by a sharp fall to a low level of 35% on day 2 of rebound, when erythropoiesis is depressed, returning to normal by day 7. The highest labelling index is found in the large transitional cells.
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D002455:Cell Division; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D000860:Hypoxia / Q000473:pathology*; D008297:Male; D051381:Rats