Mapping of dyskinetic movements induced by local application of picrotoxin or (+)-gamma-acetylenic GABA on the rat motor cortex.
Unilateral application of picrotoxin or (+)-gamma-acetylenic GABA ((+)GAG) on the cortex of rats produces a characteristic dyskinetic syndrome. Using stereotaxic coordinates, the cortical localization of these abnormal movements was mapped and found to be similar to that previously described after electrical stimulation of these cortical areas: Abnormal movements of the head and forelimb were produced by picrotoxin of (+)GAG applied to sites more anteriorly and of the hindlimb more posteriorly. The degree enzyme inhibition following application of (+)GAG was used to demonstrate a very limited degree of drug diffusion. These results suggest that interferences with GABAergic function in well-defined cortical areas may play a role in dyskinetic movement disorders.
D000480:Alkynes; D000614:Aminocaproates / Q000008:administration & dosage; D000818:Animals; D007267:Injections; D008297:Male; D009044:Motor Cortex / Q000187:drug effects* / Q000201:enzymology; D009069:Movement Disorders / Q000503:physiopathology*; D010852:Picrotoxin / Q000008:administration & dosage; D051381:Rats
D000480:Alkynes; D000614:Aminocaproates; D010852:Picrotoxin; C013785:4-amino-5-hexynoic acid