Levels of microsomal drug-metabolizing enzymes in animals which are highly susceptible to aflatoxin carcinogenicity: the case of the duck.
A comparative study of the microsomal fractions of the duck and rat has shown significant differences in the total protein contents in these fractions and also in the activities of 2 phase I drug-metabolizing enzymes, ethylmorphine N-demethylase and aniline hydroxylase. These results are discussed in relation to the high susceptibility of birds (especially ducks) to toxic or carcinogenic substances.
D000348:Aflatoxins / Q000633:toxicity*; D000815:Aniline Hydroxylase / Q000032:analysis; D000818:Animals; D004372:Ducks / Q000378:metabolism*; D004721:Endoplasmic Reticulum / Q000201:enzymology; D005037:Ethylmorphine-N-Demethylase / Q000032:analysis; D008658:Inactivation, Metabolic; D008099:Liver / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009369:Neoplasms / Q000139:chemically induced / Q000662:veterinary*; D011201:Poultry Diseases / Q000139:chemically induced*; D011506:Proteins / Q000032:analysis; D051381:Rats; D013045:Species Specificity
D000348:Aflatoxins; D011506:Proteins; D000815:Aniline Hydroxylase; D005037:Ethylmorphine-N-Demethylase