title: Sex chromosome and chromatin examination in gynecology.
abstract: Sex chromosome and chromatin examinations with hormone determinations were done on 41 cases seen at the gynecologic clinic suspected of having sexual developmental abnormalities. 22 (53.7%) had genetic, gonadal or hormonal abnormalities, including ovarian dysgenesis 9 cases, superfemale 1 case, XY pure gonadal dysgenesis 4 cases, 3 of whom had already developed gonadal malignancy, pseudovaginal perineoscrotal hypospadias 1 case, androgen insensitivity syndrome 2 cases and congenital adrenal hyperplasia 3 cases. The values and limitations of sex chromosome and chromatin examinations as well as the prevention of gonadal malignancy are discussed.
mesh_terms: D000293:Adolescent; D000312:Adrenal Hyperplasia, Congenital / Q000473:pathology; D000328:Adult; D013734:Androgen-Insensitivity Syndrome / Q000473:pathology; D002675:Child, Preschool; D012734:Disorders of Sex Development / Q000235:genetics* / Q000473:pathology; D005260:Female; D006059:Gonadal Dysgenesis / Q000235:genetics / Q000473:pathology; D006801:Humans; D007021:Hypospadias / Q000235:genetics / Q000473:pathology; D007621:Karyotyping; D007986:Luteinizing Hormone / Q000097:blood; D012728:Sex Chromatin; D012729:Sex Chromosome Aberrations; D012730:Sex Chromosomes; D014424:Turner Syndrome / Q000235:genetics / Q000473:pathology; D014626:Vaginal Smears
chemical_list: D007986:Luteinizing Hormone