Inverse relationship between whole brain monoamine levels and audiogenic seizure susceptibility in mice: failure to replicate.
Whole brain levels of 5-HT and NE in audiogenic seizure susceptible DBA mice were compared with those of the nonsusceptible C57BL/6 strain at different ages and in two separate laboratories that used different assay procedures. Contrary to previous reports, there were not significant differences between the susceptible and nonsusceptible animals in whole brain levels of either amine at the age of peak seizure susceptibility. Differential stress associated with capturing the susceptible mice had no effect on brain levels of NE. The data question the suggestion that deficits in brain monoamine transmission capable of being indexed by lower whole brain levels of NE and/or 5-HT play a role in genetically determined susceptibility to audiogenic seizures.
D000161:Acoustic Stimulation; D000375:Aging; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009638:Norepinephrine / Q000378:metabolism; D012640:Seizures / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism; D013312:Stress, Physiological / Q000378:metabolism
D001679:Biogenic Amines; D012701:Serotonin; D009638:Norepinephrine