Colon tumor specific nuclear antigen with potential as a pre-tumor diagnostic probe.
Tumor specific nuclear antigen was demonstrated in early stages of chemically-induced colon carcinogenesis. At these early stages, there is no observable nuclear or cytoplasmic alteration in the colon mucosae. The rise in tumor specific nuclear antigen in carcinogen-treated animals can be abolished by simultaneous treatment with carcinogen inhibitor. The potential for tumor specific nuclear antigen to be used as a pretumor diagnostic probe is discussed.
D000818:Animals; D000951:Antigens, Neoplasm / Q000276:immunology*; D002467:Cell Nucleus / Q000276:immunology*; D003106:Colon / Q000473:pathology; D003110:Colonic Neoplasms / Q000175:diagnosis / Q000276:immunology* / Q000473:pathology; D004127:Dimethylhydrazines; D004221:Disulfiram / Q000627:therapeutic use; D008297:Male; D009374:Neoplasms, Experimental / Q000276:immunology; D011230:Precancerous Conditions / Q000175:diagnosis / Q000276:immunology; D051381:Rats
D000951:Antigens, Neoplasm; D004127:Dimethylhydrazines; D004221:Disulfiram