The mechanism of hyperlipidaemia in nephrotic syndrome--role of low albumin and the LCAT reaction.
Diminished autologous LCAT activity was found in patients with proteinuria. This was due to substrate limitation and albumin appeared the most likely limiting factors. It is suggested that low albumin can contribute to the hyperlipidaemia of nephrotic syndrome through its role on the LCAT reaction. Evidence of the ability of triglyceride to enhance homologous LCAT activity was also noted.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000378:metabolism*; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism*; D011507:Proteinuria / Q000378:metabolism; D012709:Serum Albumin / Q000378:metabolism*
D008075:Lipoproteins, HDL; D012709:Serum Albumin; D007862:Phosphatidylcholine-Sterol O-Acyltransferase