Macbecins I and II, new antitumor antibiotics. II. Isolation and characterization.
New antitumor antibiotics, macbecins I and II, were isolated from the culture broth of Nocardia sp. No. C-14919. Macbecins I and II belong to the ansamycin group and have a benzoquinone and hydroquinone nucleus, respectively. Both showed antitumor activity against murine leukemia P 388 in vivo.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis / Q000302:isolation & purification* / Q000494:pharmacology; D016227:Benzoquinones; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D047029:Lactams, Macrocyclic; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D009615:Nocardia / Q000378:metabolism; D010084:Oxidation-Reduction; D011809:Quinones / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D016227:Benzoquinones; D047029:Lactams, Macrocyclic; D011809:Quinones; C025514:macbecin I; C025515:macbecin II