Phlogistic properties of the serum proteins, albumin and transferrin.
In the experimental model for inflammation, footpad edema induced by injections of monosodium urate crystals, effects of two acute-phase reactants, the carrier proteins albumin and transferrin, were studied. Addition of small amounts of these serum components to the test system resulted in greater swelling. A dose-related response was demonstrated. Doubling the amount of transferrin produced increased inflammation. Comments are presented on the possible protective role of pertubations in the serum proteins classified as acute-phase reactants in the organism's response to tissue injury or inflammation.
D000818:Animals; D000893:Anti-Inflammatory Agents; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D012709:Serum Albumin / Q000494:pharmacology*; D014168:Transferrin / Q000494:pharmacology*; D014527:Uric Acid / Q000276:immunology
D000893:Anti-Inflammatory Agents; D012709:Serum Albumin; D014168:Transferrin; D014527:Uric Acid