title: Lung ventilation model for radioactive tracer itdal breathing.
abstract: A mathematical lung ventilation model for radioactive tracer tidal breathing is developed on the basis of the previously established simple mathematical lung model for quantitative regional ventilation measurements. In the present model, the periodicity of breathing is completely taken into account. A precise definition of the effective specific ventilation is given. This was found to be related to the ratio of tidal volume (TV) and functional residual capacity (FRC). The determination of the regional effective specific ventilation is reduced to a simple fitting to a straight line. A description is given of the method of measurement (in the framework of radioisotope dynamic studies) that makes it possible to use the mathematical model for the actual determination of lung ventilation and volume parameters. The model is experimentally verified on healthy subjects, and the value of the effective specific ventilation obtained is in agreement with comparable parameters in the literature. Furthermore, the value for TV/FRC is comparable with that determined by classical spirometrical methods.
mesh_terms: D006801:Humans; D007726:Krypton; D008176:Lung Volume Measurements; D008433:Mathematics; D008954:Models, Biological; D011868:Radioisotopes; D012119:Respiration; D013990:Tidal Volume
chemical_list: D011868:Radioisotopes; D007726:Krypton