[Effect of antihepatocytotoxic serum on processes of cellular and intracellular regeneration of pathologically altered liver].
The parameters of the liver regeneration: mitotic index, DNA synthesis, nucleolar size of hepatocytes and histological structure, were studied in adult female rats with CCl4-affected liver during administration of the gamma-globulin fraction of antihepatocytotoxic serum (gamma-AHCS). It was shown that in various periods after exposure to CCl4 either the cellular processes of regeneration are predominant or the intracellular ones. gamma-AHCS (0.06 microgram protein per 100g body weight/one injection) intensifies and makes longer both the processes.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications / Q000473:pathology / Q000628:therapy*; D002467:Cell Nucleus / Q000648:ultrastructure; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology / Q000473:pathology / Q000628:therapy*; D004247:DNA / Q000096:biosynthesis; D005260:Female; D007116:Immunization, Passive; D008099:Liver / Q000276:immunology* / Q000378:metabolism / Q000473:pathology; D008115:Liver Regeneration; D008940:Mitotic Index; D051381:Rats
D004247:DNA
Vliianie antigepatotsitotoksicheskoĭ syvorotki na protsessy kletochnoĭ i vnutrikletochnoĭ regeneratsii patologicheski izmenennoĭ pecheni.