The role of D-1 and D-2 receptors.
Dopamine receptors in intracerebral motor and endocrine systems have been divided into two main types, D-1 and D-2, dependent on the presence or absence of adenylate cyclase linkage. Here we have investigated a number of dopamine agonist and antagonist drugs in man that have different actions on D-1 and D-2 receptors in animals. Motor and endocrine effects in parkinsonian subjects seem to depend on drug interaction with D-2, but not D-1, receptors. These results may have important implications for the design of anti-parkinsonian and antipsychotic agents.
D000262:Adenylyl Cyclases / Q000378:metabolism; D001971:Bromocriptine / Q000494:pharmacology; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007980:Levodopa / Q000494:pharmacology; D008090:Lisuride / Q000494:pharmacology; D008787:Metoclopramide / Q000494:pharmacology; D010300:Parkinson Disease / Q000188:drug therapy*; D010868:Pimozide / Q000494:pharmacology; D011388:Prolactin / Q000097:blood; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*
D011954:Receptors, Dopamine; D010868:Pimozide; D001971:Bromocriptine; D007980:Levodopa; D011388:Prolactin; D013006:Growth Hormone; D008090:Lisuride; D000262:Adenylyl Cyclases; D008787:Metoclopramide