Correlation of alkaline phosphatase with submucosal blood flow and morbid histology of the ischemic colon.
In an ischemic Thiry-Vella colonic segment which was constructed to facilitate the serial measurement of submucosal blood flow by radioxenon clearance, we found that, after producing ischemia, the submucosal xenon clearance fell from 68+/-3 to 21+/-4 percent. In the succeeding two hours, a further fall in xenon clearance to 16+/-3 per cent occurred as a result of vasoconstriction in the peripheral mesenteric bed. From 24 hours onward, the submucosal flow increased. However, throughout the 96 hours, no healing of the ischemic necrosis was seen in the mucosa, and submucosa. Serial alkaline phosphatase levels showed a great rise from 24 hours onward, and began to fall as submucosal blood flow increased. This rise in the alkaline phosphatase value appears a useful marker of the degree of ischemia of the intestinal wall.
D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D001783:Blood Flow Velocity; D003106:Colon / Q000098:blood supply* / Q000473:pathology / Q000503:physiopathology; D004285:Dogs; D005260:Female; D007413:Intestinal Mucosa / Q000201:enzymology / Q000473:pathology; D007511:Ischemia / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008954:Models, Biological; D014980:Xenon Radioisotopes
D014980:Xenon Radioisotopes; D000469:Alkaline Phosphatase