Ectopic production of "pregnancy-specific" beta-1 glycoprotein in vitro: discordance with three other placental proteins.
"Pregnancy-specific" beta-1 glycoprotein (SP1) was produced in vitro by nine of 32 established cell lines derived from human malignant neoplasms. The nine positive lines comprised a variety of cell types, and SP1 production ranged from 0.36 to 35.5 pmol/mg cell protein at confluence. The highest production was by a fibrosarcoma line. SP1 in medium and cells from this line was indistinguishable immunochemically and gel chromatographically from purified (Bohn) placental SP1. None of the SP1-positive lines produced placental lactogen, only three produced the alpha subunit of chorionic gonadotropin (CG), and only four produced the beta subunit of CG. SP1-positive lines that produced cg-alpha did not produce CG-beta. Secretion of SP1 and of CG-beta by the fibrosarcoma line followed different time courses.
D001254:Astrocytoma / Q000378:metabolism; D002277:Carcinoma / Q000378:metabolism; D002460:Cell Line; D006063:Chorionic Gonadotropin / Q000378:metabolism; D005260:Female; D005354:Fibrosarcoma / Q000378:metabolism*; D005910:Glioma / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D006801:Humans; D008545:Melanoma / Q000378:metabolism; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D012509:Sarcoma / Q000378:metabolism
D006063:Chorionic Gonadotropin; D006023:Glycoproteins