Halothane anesthesia and respiratory mechanics in dogs lying supine.
Functional residual capacity (FRC) and quasi-static deflation pressure-volume (PV) curves of the total respiratory system, lung, and chest wall were measured in eight trained dogs lying supine, first awake and then anesthetized with halothane. Two of the eight dogs were repetitively examined 10 times during a 15-mo period. FRC decreased with anesthesia in six of the eight dogs and incresed with anesthesia in the remaining two dogs. There was a significant mean anesthesia-induced reduction in FRC of 16.9% (P < 0.05). FRC change with anesthesia varied between studies in one of the two dogs repetitively examined. Mean PV curves of the total system, lung, and chest wall of the six dogs whose FRC decreased with anesthesia were shifted to the right by anesthesia. PV curves from the two dogs whose FRC increased with anesthesia were shifted to the left. Anesthesia produced a significant reduction (P < 0.05) in mean lung compliance and significant increases (P < 0.05) in mean chest wall and total system compliances.
D000769:Anesthesia, Inhalation; D000818:Animals; D004285:Dogs; D005652:Functional Residual Capacity; D006221:Halothane; D008170:Lung Compliance / Q000187:drug effects; D008297:Male; D012123:Pulmonary Ventilation / Q000187:drug effects*; D014109:Total Lung Capacity
D006221:Halothane