High-pressure liquid chromatographic identification of drugs used in management of arthritis.
A screening procedure was developed for the identification of drugs used in the clinical treatment of arthritis. Each glucocorticoid, nonsteroidal anti-inflammatory agent, or tranquilizer was characterized by its retention on a reversed-phase high-pressure liquid chromatographic column and by the ratio of the response of dual UV detectors (254 and 280 nm). Although the retention times of all 14 drugs examined were less than 4 min. each drug could be distinguished easily from the other drugs in the series.
D000893:Anti-Inflammatory Agents / Q000032:analysis*; D001168:Arthritis / Q000188:drug therapy*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D005938:Glucocorticoids / Q000032:analysis*; D006801:Humans; D014149:Tranquilizing Agents / Q000032:analysis
D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D014149:Tranquilizing Agents