title: [Age and features of DNA replication in intact white rat liver].
abstract: Studies on 3H-thymidine incorporation into DNA of 6- and 24-month-old rat liver have shown that part of newly formed DNA of both adult and old species is extracted as single-stranded after hydroxyapatite chromatography. This single-stranded DNA seems likely to be an intermediate product of DNA replication. The transition of the newly formed single-stranded DNA to double stranded proceeds more slowly in the liver of old animals than in adult ones.
mesh_terms: D000367:Age Factors; D000818:Animals; D004261:DNA Replication; D004277:DNA, Single-Stranded / Q000378:metabolism; D005260:Female; D008099:Liver / Q000378:metabolism*; D008115:Liver Regeneration; D009841:Oligonucleotides / Q000378:metabolism; D051381:Rats; D013936:Thymidine / Q000378:metabolism; D013997:Time Factors
chemical_list: D004277:DNA, Single-Stranded; D009841:Oligonucleotides; D013936:Thymidine
vernacular_title: Vozrastnye osobennosti replikatsii DNK v intaktnoĭ pecheni belykh krys.