Myositis ossificans following forcible manipulation of the leg. A rabbit model for the study of heterotopic bone formation.
The right hind limbs of forty-four rabbits were immobilized with the knee in extension for as long as five weeks, except for a daily session of forcible mobilization lasting five minutes. Within five weeks there was progressive heterotopic-bone formation in the quadriceps muscle. The roentgenographic and histological changes were similar to those seen in human myositis ossificans.
D000818:Animals; D004195:Disease Models, Animal; D005121:Extremities / Q000000981:diagnostic imaging; D007103:Immobilization; D009068:Movement; D009132:Muscles / Q000473:pathology; D009221:Myositis Ossificans / Q000209:etiology* / Q000473:pathology; D009336:Necrosis; D010012:Osteogenesis; D011817:Rabbits; D011859:Radiography