Histamine H1-receptors labeled in vivo: antidepressant and antihistamine interactions.
3H-Mepyramine labels specific histamine H1-receptors in brains of mice after intravenous injection. The potencies of H1-antihistamines in reducing 3H-mepyramine binding in vivo correspond to their pharmacological activities and show parallels with their affinities for 3H-mepyramine binding sites in isolated brain membranes. Several antidepressants are potent in competing for 3H-mepyramine binding in vivo as well as in vitro.
D000818:Animals; D000928:Antidepressive Agents / Q000378:metabolism*; D001665:Binding Sites; D001921:Brain / Q000378:metabolism; D002744:Chlorpheniramine / Q000378:metabolism; D004347:Drug Interactions; D006633:Histamine Antagonists / Q000378:metabolism*; D066298:In Vitro Techniques; D007553:Isotope Labeling; D051379:Mice; D011738:Pyrilamine / Q000378:metabolism; D011968:Receptors, Histamine / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D013997:Time Factors; D014316:Tritium
D000928:Antidepressive Agents; D006633:Histamine Antagonists; D011968:Receptors, Histamine; D011969:Receptors, Histamine H1; D014316:Tritium; D002744:Chlorpheniramine; D011738:Pyrilamine