title: Aspects of intra-uterine fetal resuscitation.
abstract: An analogy may be drawn between the lungs and placenta regarding distribution and matching of their exchanging flows. Furthermore, prostaglandins probably play a role in restoring the normal pulmonary ventilation-to-perfusion ratio (V/Q) and the uterine (maternal)-to-umbilical (fetal) placental perfusion ratio (Q-q). Availability of oxygen to the fetal brain is probably independent of PaO2, provided cerebral tissue PO2 is above a certain critical level. Oxygen content rather than PO2 of the blood perfusing the fetal brain is the prime factor in maintaining adequate cerebral oxygenation. With the above physiological consideration in mind, the concept of intra-uterine fetal resuscitation is presented. The hypothesis that low concentrations of aneasthetic vapours and 60% oxygen inhaled by the mother in the presence of fetal distress improve placental blood flow matching, and hence fetal cerebral oxygenation, is discussed.
mesh_terms: D005260:Female; D005333:Fetus / Q000502:physiology*; D006801:Humans; D007743:Labor, Obstetric; D008168:Lung / Q000502:physiology; D008431:Maternal-Fetal Exchange; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption; D010313:Partial Pressure; D011247:Pregnancy
chemical_list: D010100:Oxygen