Evidence that endogenous ecotropic virus is not expressed in AKR thymic lymphoid cells of chimeric hosts.
AKR/J thymocytes derived from fetal liver cells do not produce virus when they differentiate in lethally irradiated B10.K mice, whereas spleen and bone marrow cells are virus producers. In contrast, B10.K thymocytes that differentiate in lethally irradiated AKR mice become virus producers. These results suggest that infection of the thymus in AKR mice is initiated in thymic stromal cells.
D000818:Animals; D001853:Bone Marrow / Q000382:microbiology; D008223:Lymphoma / Q000209:etiology; D051379:Mice; D008806:Mice, Inbred AKR; D011828:Radiation Chimera; D012190:Retroviridae / Q000254:growth & development*; D013154:Spleen / Q000382:microbiology; D013945:Thymoma / Q000209:etiology; D013950:Thymus Gland / Q000382:microbiology*; D013953:Thymus Neoplasms / Q000209:etiology