title: 16 S acetylcholinesterase in endplate-free regions of developing rat diaghragm.
abstract: Velocity sedimentation patterns of acetylcholinesterase (AChE, EC 3.7.1.1) in endplate-free regions of the diaphragm were studied in rats during early postnatal development. A significant amount of 16 S AChE, comprising 20% total activity, was found in endplate-free regions of the diaphragm of 8- and 19-day-old rats. By 32 days after birth, 16 S AChE accounted for less than 5% total AChE activity in endplate-free regions. 16 S AChE is, therefore, not strictly an endplate-specific molecular form. Instead, it becomes restricted to the motor endplate region of the rat diaphragm by the end of the first month of life.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000375:Aging; D000818:Animals; D003964:Diaphragm / Q000201:enzymology / Q000254:growth & development*; D008297:Male; D008968:Molecular Conformation; D009045:Motor Endplate / Q000201:enzymology; D024510:Muscle Development; D051381:Rats
chemical_list: D000110:Acetylcholinesterase