[Malignant tumor induction in mice by methylcholanthrene covalently bound to bovine serum albumin].
The cancerogenic properties of 3-methylcholantrene covalently bound to protein through bis-diasotated benzidin were studied in mouse experiments. It has been shown that protein binding does not abolish the cancerogenic activity: subcutaneous administration of the conjugate gives rise to a rapid development of sarcomas at the injection sites. This makes difficult the immunization of the animals with the conjugated antigen 3-methylcholantrene-protein with a purpose of producing antibodies that would specifically bind the cancerogenic substance.
D000818:Animals; D002273:Carcinogens; D005260:Female; D008297:Male; D008748:Methylcholanthrene / Q000008:administration & dosage* / Q000633:toxicity; D051379:Mice; D011485:Protein Binding; D012513:Sarcoma, Experimental / Q000139:chemically induced*; D012710:Serum Albumin, Bovine / Q000008:administration & dosage
D002273:Carcinogens; D012710:Serum Albumin, Bovine; D008748:Methylcholanthrene
Induktsiia zlokachestvennoĭ opukholi u mysheĭ metilkholantrenom, kovalentno sviazannym s bych'im syvorotochnym al'buminom.