Drug sensitivity studies on clonal cell lines isolated from heteroploid tumor cell population. II. Sensitivity of clones growing in suspension cultures.
NK/S cell line and its clonal lines 6 and 10 were established in culture from NK/Ly mouse lymphoma. The clones differed from each other and from the parent line in chromosome pattern and growth rate. Clone 6 cells were polyploid and more sensitive to dianhydrogalactitol than the diploid clone 10 cells. However, clone 10 cells were more sensitive to adriamycin. A very small difference in sensitivity was found with vincristine. It was concluded that sensitivity of clones originating from the same parent population is drug-related.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002999:Clone Cells / Q000187:drug effects; D003961:Dianhydrogalactitol / Q000494:pharmacology*; D004317:Doxorubicin / Q000494:pharmacology*; D004351:Drug Resistance; D008223:Lymphoma / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D011003:Ploidies / Q000187:drug effects; D013402:Sugar Alcohols / Q000494:pharmacology*; D013535:Suspensions; D014750:Vincristine / Q000494:pharmacology*
D013402:Sugar Alcohols; D013535:Suspensions; D003961:Dianhydrogalactitol; D014750:Vincristine; D004317:Doxorubicin