Evidence for independent regulation of dolichol and cholesterol synthesis in developing mouse brain.
In order to investigate the regulatory inter-relationships between the branching pathways of dolichol and cholesterol synthesis, we have measured the changing rates of synthesis for these two lipids in developing mouse brains. A sharp peak in the rate of dolichol synthesis occured at 3-7 days after birth which did not coincide with changes in cholesterol synthesis, suggesting independent regulation of dolichol and cholesterol synthesis in developing mouse brains.
D000818:Animals; D000831:Animals, Newborn / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002784:Cholesterol / Q000096:biosynthesis*; D004224:Diterpenes / Q000096:biosynthesis*; D004286:Dolichols / Q000096:biosynthesis*; D066298:In Vitro Techniques; D051379:Mice; D008811:Mice, Inbred DBA / Q000378:metabolism; D013997:Time Factors
D004224:Diterpenes; D004286:Dolichols; D002784:Cholesterol