Effect of treatment with phenformin, diphenylhydantoin or L-dopa on life span and tumour incidence in C3H/Sn mice.
The chronic treatment of female C3H/Sn mice with phenformin (2 mg/day) and diphenylhydantoin (2 mg/day) prolonged mean life span by 23 and 25%, respectively, and decreased spontaneous tumour incidence by 4.0 and 2.3 times, respectively. The chronic treatment of mice with L-dopa (2 mg/day) did not change these parameters and decreased the multiplicity of mammary tumours. The mechanisms of the drug action on mouse life span and tumour incidence are discussed.
D000230:Adenocarcinoma / Q000517:prevention & control; D000375:Aging / Q000187:drug effects*; D000818:Animals; D005260:Female; D007942:Leukemia, Experimental / Q000517:prevention & control; D007980:Levodopa / Q000494:pharmacology*; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control; D051379:Mice; D008809:Mice, Inbred C3H; D009374:Neoplasms, Experimental / Q000517:prevention & control*; D010629:Phenformin / Q000494:pharmacology*; D010672:Phenytoin / Q000494:pharmacology*
D007980:Levodopa; D010672:Phenytoin; D010629:Phenformin