Plasma alpha 2HS-glycoprotein concentration in Paget's disease of bone: its possible significance.
1. The plasma concentration of the alpha 2HS-glycoprotein has been measured in 58 normal adults and in patients with Paget's disease of bone before (24) and during treatment (16). 2. The average plasma alpha 2HS-glycoprotein was lower in the patients with Paget's disease than in the normal adults and was inversely related to plasma alkaline phosphatase activity (r = -0.55, n = 24, P less than 0.001). 3. When the patients with Paget's disease were treated with either diphosphonate or calcitonin, the plasma alpha 2HS-glycoprotein concentration increased towards normal. In those patients treated with calcitonin, this increase was too rapid to be entirely accounted for by a cessation of bone formation.
D000368:Aged; D000469:Alkaline Phosphatase / Q000378:metabolism; D002116:Calcitonin / Q000627:therapeutic use; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D005353:Fibronectins / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000097:blood* / Q000188:drug therapy; D012709:Serum Albumin / Q000032:analysis
D004164:Diphosphonates; D005353:Fibronectins; D012709:Serum Albumin; D002116:Calcitonin; D000469:Alkaline Phosphatase