Ultrasound scanning of ovaries to detect ovulation in women.
Healthy volunteers with regular ovarian function, women taking oral contraceptives, and infertile patients being treated with clomiphene were studied longitudinally from day 7 of the cycle to menstruation. The main objective was to determine whether ovulation or failure to ovulate could be detected accurately by the use of ultrasound. The ovaries were scanned with a Kretz Combison 100 sector scanner every 1 to 3 days for morphologic changes consistent with follicle development, ovulation, and development of the corpus luteum. The morphologic changes were correlated with daily urinary hormone profiles. The estimated times of ovulation according to ultrasound and luteinizing hormone peak overlapped by 24 hours in 19 of 23 normal cycles and in 5 of 6 cycles of patients treated with clomiphene. Both techniques indicated that three of three women taking oral contraceptives did not ovulate. The ultrasound studies indicated a wide range in the diameter of the preovulatory follicle, which precludes follicular diameter as a single index for prediction of ovulation. However, by measuring the maximal diameter of the follicle and observing the morphologic changes within the ovary from follicle to corpus luteum, it was possible to detect ovulation in more than 80% of cycles studied. This technique was found to be quick, inexpensive, and efficient.
D002996:Clomiphene / Q000627:therapeutic use; D003276:Contraceptives, Oral / Q000494:pharmacology; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy; D008598:Menstruation / Q000187:drug effects; D010053:Ovary / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects; D010061:Ovulation Detection; D014463:Ultrasonography
D003276:Contraceptives, Oral; D002996:Clomiphene