High-performance liquid chromatographic analysis of dipyridamole in plasma and whole blood.
A rapid, sensitive, and specific high-performance liquid chromatographic method is described for the quantitative analysis of dipyridamole in plasma and whole blood. The method involves a single extraction of an alkalinized sample with diethyl ether followed by evaporation of the organic solvent and ion-pair chromatography using fluorescence detection. The lower limit of sensitivity for dipyridamole is 1 ng/ml. Concentrations of dipyridamole between 1 and 500 ng per sample are measured with an average coefficient of variation of 4.5% in plasma and 7.4% in whole blood.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D004176:Dipyridamole / Q000097:blood*; D005260:Female; D006801:Humans; D007700:Kinetics; D008832:Microchemistry; D010949:Plasma / Q000032:analysis; D013050:Spectrometry, Fluorescence
D004176:Dipyridamole