Prostaglandin-synthesizing system in rat liver homogenates: ATP shifts arachidonic acid away from cyclooxygenase into phospholipids.
Mechanism of the inhibition by tahe rat liver cytosol of prostaglandin synthesis in rat liver microsomes was studied. All the evidence strongly suggests that the factor present in liver cytosol causing a shift of arachidonic acid utilizaiton away from prostaglandins towards incorporation into phospholipids is ATP.
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D003065:Coenzyme A / Q000494:pharmacology; D003600:Cytosol / Q000378:metabolism*; D006160:Guanosine Triphosphate / Q000494:pharmacology; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism*; D010105:Oxygenases / Q000378:metabolism; D010743:Phospholipids / Q000378:metabolism; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats
D010743:Phospholipids; D011453:Prostaglandins; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D010105:Oxygenases; D003065:Coenzyme A