Simultaneous Hodgkin's disease in three siblings with identical HLA-genotype.
We report 3 cases of Hodgkin's disease (HD) within a family of seven children. All three children had mixed cellularity type in different  stages of the disease (IV-B, III-A, and II-A). The diagnosis was made within a one-month interval. HLA typing shows an identical genotype in the 3 HD patients, which was different from the rest of the family. One of the patients developed an idiopathic thrombocytopenic purpura (ITP) with temporary response to prednisone and MOPP-C chemotherapy that subsided after splenectomy. The HLA identity, in addition to the simultaneous onset of the HD, suggests a combination of both genetic and environmental factors in the pathogenesis of this disease.
D001706:Biopsy; D002648:Child; D005260:Female; D006680:HLA Antigens / Q000235:genetics*; D006689:Hodgkin Disease / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D010375:Pedigree
D006680:HLA Antigens