The influence of a cholesterol-free semisynthetic diet on the lipid metabolism in rabbits.
The influence of a cholesterol-free, semi synthetic diet on the total lipid synthesis and on the lipid content of serum, liver, aorta and intestinal mucosa of the rabbit was tested for the duration of three months, and, respectively, six months. Also, the changes in these parameters after a 38-hour period of fasting was examined. The total lipid synthesis in the liver and aorta ran parallel to the lipid level in serum with a peak in radioacetate incorporation into total lipids occuring after three months. In contrast to this the rate of lipid synthesis in the mucosa continued to rise throughout the entire test period. While the lipid content of the mucosa remained unchanged by the diet, it rose in the liver and aorta. The effect of fasting in the three organs was greater after three months than after six months in respect to the incorporation of radioacetate. The serum lipids, too, sank further during fasting after three months than after six.
D000818:Animals; D001011:Aorta / Q000378:metabolism; D002791:Cholesterol, Dietary / Q000008:administration & dosage*; D004036:Diet, Atherogenic; D005526:Food, Formulated; D007413:Intestinal Mucosa / Q000378:metabolism; D008055:Lipids / Q000096:biosynthesis* / Q000097:blood; D008099:Liver / Q000378:metabolism; D011817:Rabbits; D013217:Starvation / Q000378:metabolism
D002791:Cholesterol, Dietary; D008055:Lipids