Modulating effect by zinc on hepatic lysosomal fragility induced by surface-active agents.
In vitro studies on rat hepatic lysosomal stability, as assessed by release of beta-glucuronidase, were undertaken to demonstrate the comparative influence of surface-active agents which act by various mechanisms. Bile acids, short chain alcohols, acetylsalicylic acid, and Triton X-100 were studied, as well as their interaction with zinc. The detergents and alcohols enhanced release of this acid hydrolase in a dose dependent fashion, but acetylsalicylic acid did not. Zinc antagonized these effects in a non-specific manner. It is postulated that zinc stabilized lysosomes by direct action on the lysosomal membrane, such as by surface protein interactions, but the precise mechanism remains unknown.
D000438:Alcohols / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000494:pharmacology; D001647:Bile Acids and Salts / Q000494:pharmacology; D004347:Drug Interactions; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure*; D008247:Lysosomes / Q000187:drug effects*; D008297:Male; D009996:Osmotic Fragility / Q000187:drug effects; D011092:Polyethylene Glycols / Q000494:pharmacology; D051381:Rats; D013501:Surface-Active Agents / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology*
D000438:Alcohols; D001647:Bile Acids and Salts; D013501:Surface-Active Agents; D011092:Polyethylene Glycols; D015032:Zinc; D001241:Aspirin