Neonatal neuronal necrosis: its relationship to the distribution and maturation of oxidative enzymes of newborn cerebral and cerebellar cortex.
Seventeen brains showing neuronal necrosis after severe perinatal 'asphyxia' were re-examined. In particular the distribution of lesions, which generally involved all layers of the cerebral cortex and was only occasionally laminar, was contrasted with the laminar pattern of maturation of oxidative enzymes in comparable regions of normal newborn brains. In the cerebellum, where necrosis of neurones of the vermis was prominent compared with relative sparing of neurones of the lateral hemispheres, a closer correlation with the pattern of maturation of oxidative enzymes was noted. The rarity of laminar necrosis in the cerebral hemispheres suggests that factors other than pure hypoxic-hypoxia are important in most cases in determining the distribution of lesions, whereas in the cerebellum the earlier maturation of neurones and hypoxic-hypoxia per se are important in determining the localization of lesions.
D001238:Asphyxia Neonatorum / Q000201:enzymology / Q000473:pathology*; D002525:Cerebellar Cortex / Q000201:enzymology / Q000473:pathology*; D002540:Cerebral Cortex / Q000201:enzymology / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D009336:Necrosis; D009474:Neurons / Q000648:ultrastructure; D010088:Oxidoreductases / Q000378:metabolism*
D010088:Oxidoreductases