Histamine flare, a neurovascular response.
It has been shown that the histamine flare depends on the integrity of sympathetic innervation and of connecting pathways between the sympathetic nervous system and higher centers. This conclusion was reached on the basis of lack of skin responses to exogenous histamine in 75% of patients with spinal cord injury in this study.
D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006632:Histamine; D006801:Humans; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000098:blood supply / Q000294:innervation*; D013119:Spinal Cord Injuries / Q000503:physiopathology
D006632:Histamine