Acylthioxanthenes: agents which selectively reduce decerebrate rigidity in the cat.
A series of 2-acylthioxanthene-delta 9 (gamma)-propylamines was synthesized, and their effect of reducing the intercollicular decerebrate rigidity in the cat was evaluated. The compound exhibiting the greatest separation between the dosage that reduced rigidity and that which caused sedation was (Z)-2-propionyl-9-[3-(dimethylamino)propylidene]thioxanthene. The separation of Z and E isomers was monitored by 1H NMR spectroscopy, using an europium shift reagent.
D000284:Administration, Oral; D000818:Animals; D002415:Cats; D003655:Decerebrate State / Q000503:physiopathology*; D007263:Infusions, Parenteral; D007536:Isomerism; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013329:Structure-Activity Relationship; D013892:Thioxanthenes / Q000008:administration & dosage / Q000138:chemical synthesis / Q000494:pharmacology*
D013892:Thioxanthenes