title: [Histochemical study of lysosomal enzymes in the synovial membrane of the rheumatoid arthritis (author's transl)].
abstract: Synovial membrane obtained from the patients, in number of twenty one, suffering from the rheumatoid arthritis of classical type, was surveyed from the stand-point of enzyme histochemistry concentrating on lysosomal enzyme. Examined enzymes were leucine aminopeptidase, acid phosphatase and beta-glucuronidase. The activities of respective enzymes were compared with clinical and pathological activities of disease in each cases. It has been known that these lysosomal enzymes indicate high activity not only in chemical analysis of synovial membrane, but also histochemical observation. The origin of these enzymes, however, has not yet been determined as being derived of the synovial tissue or inflammatory cells. In the present investigation, it has been clarified that the enzyme activities were well localized at lining cell layer, but no activation of enzyme in the inflammatory cells in tissue. Therefore, it is suggested that lysosomal enzyme activity may be one of the factors which act on the destructive process in the rheumatoid arthritis.
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000328:Adult; D000368:Aged; D001172:Arthritis, Rheumatoid / Q000201:enzymology*; D005260:Female; D005966:Glucuronidase / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D007931:Leucyl Aminopeptidase / Q000032:analysis; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D013583:Synovial Membrane / Q000201:enzymology* / Q000473:pathology
chemical_list: D000135:Acid Phosphatase; D005966:Glucuronidase; D007931:Leucyl Aminopeptidase