Aborting solid tumours: a possible role for PGF2alpha.
As well as being an efficacious abortifacient agent, PGF2alpha is known to be an endogenous mediator of parturition. It is the hypothesis of this paper that PGF2 alpha may also be an effective macrophage tumouricidal activator; if correct, PGF2alpha may be said to 'abort' tumour cell mass. Indirect evidence for such a mechanism of action, as well as a theory as to the mode of action itself, is presented.
D000818:Animals; D005260:Female; D006801:Humans; D007743:Labor, Obstetric; D008264:Macrophages / Q000276:immunology; D051379:Mice; D008962:Models, Theoretical; D009365:Neoplasm Regression, Spontaneous; D009369:Neoplasms / Q000276:immunology / Q000503:physiopathology*; D011247:Pregnancy; D011458:Prostaglandins E / Q000502:physiology; D011460:Prostaglandins F / Q000502:physiology*
D011458:Prostaglandins E; D011460:Prostaglandins F