[Problems in diagnostics of histoplasmosis (author's transl)].
This report deals with three observations of Histoplasma mycosis (one acquired in Western Africa - large cell form; two in the USA - classical form) which were diagnosed from 10 to 35 years after primary infection. The laboratory diagnosis was based on immunological, histopathological and clinico-epidemiological data, since in none of the cases material was available for mycological culture. The histoplasmin skin test is considered to be the most sensitive procedure. A positive outcome may support other evidence or suspicion and may deliver an valid clue - particularly among individuals from non-endemic areas-to consider the possibility of Histoplasma infection. The demonstration of serum antibodies may assist in establishing a correct diagnosis in such cases.
D000908:Antibodies, Fungal / Q000032:analysis; D006658:Histoplasma / Q000276:immunology / Q000302:isolation & purification; D006659:Histoplasmin; D006660:Histoplasmosis / Q000175:diagnosis*; D006801:Humans; D008168:Lung / Q000382:microbiology; D012882:Skin Tests
D000908:Antibodies, Fungal; D006659:Histoplasmin
Probleme der Diagnostik bei Histoplasma-Mykose.