Rapid mobilization of ferritin iron by ascorbate in the presence of oxygen.
L-(-)-ascorbate mobilizes iron from horse-spleen ferritin in the presence of oxygen at pH 8.0. The reaction is strongly stimulated by Cu2+. Dehydroascorbate and other stable oxidation products of ascorbate are ineffective. We present evidence that monodehydroascorbate mobilizes ferritin iron by reduction.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism*; D003300:Copper / Q000378:metabolism; D003683:Dehydroascorbic Acid / Q000378:metabolism; D005293:Ferritins / Q000378:metabolism*; D006736:Horses; D006863:Hydrogen-Ion Concentration; D007501:Iron / Q000378:metabolism*; D010100:Oxygen / Q000494:pharmacology*; D013154:Spleen / Q000378:metabolism
D003300:Copper; D005293:Ferritins; D007501:Iron; D001205:Ascorbic Acid; D010100:Oxygen; D003683:Dehydroascorbic Acid