Cimetidine impairs elimination of chlordiazepoxide (Librium) in man.
We have studied chlordiazepoxide (Librium) disposition and elimination in eight normal subjects before and after 1 week of cimetidine therapy, 300 mg orally four times a day. Cimetidine strikingly impaired the clearance of chlordiazepoxide from plasma, and this was, at least in part, due to decreased demethylation of the drug to N-desmethylchlordiazepoxide. Since the volume of distribution of chlordiazepoxide was not altered by cimetidine, the elimination half-life of chlordiazepoxide was also significantly prolonged by cimetidine therapy.
D000328:Adult; D002707:Chlordiazepoxide / Q000097:blood / Q000378:metabolism*; D002927:Cimetidine / Q000008:administration & dosage / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D006146:Guanidines / Q000494:pharmacology*; D006207:Half-Life; D006801:Humans; D008099:Liver / Q000378:metabolism; D008297:Male
D006146:Guanidines; D002707:Chlordiazepoxide; D002927:Cimetidine