[The effect of immunoglobulins in experimental peritonitis (author's transl)].
We measured the influence of different drugs on mortality and lung weights in a well known and standardized peritonitis model in rats. The results are: 1. Intraperitoneal injection of immune globulin in high dosage had little effect on our parameters. High mortality and interstitial pulmonary edema were observed. 2. The same results followed injection of 20% human albumin. 3. All animals injected intraperitoneally with a modern antibiotic (Securopen) survived. Interstitial pulmonary edema was observed. 4. The combined injection of an antibiotic and immune globulin (Gamma-Venin) had the best results. None of the rats came down with a lung injection or died.
D000818:Animals; D001390:Azlocillin; D004359:Drug Therapy, Combination; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage / Q000627:therapeutic use*; D008168:Lung / Q000473:pathology; D008297:Male; D009929:Organ Size; D010406:Penicillins / Q000008:administration & dosage / Q000627:therapeutic use; D010538:Peritonitis / Q000188:drug therapy* / Q000276:immunology / Q000401:mortality; D011654:Pulmonary Edema / Q000517:prevention & control; D051381:Rats; D012709:Serum Albumin / Q000008:administration & dosage / Q000627:therapeutic use
D007136:Immunoglobulins; D010406:Penicillins; D012709:Serum Albumin; D001390:Azlocillin
Beitrag zur Effektivität der Immunglobuline bei der experimentellen Peritonitis.