Imaging approach in radioimmunodetection.
External in vivo imaging of tumors with radioactively labeled antibodies to tumor-associated antigens requires processing to remove interfering nontarget radioactivity. Processing entails the use of simulated nontarget compounds labeled with a radionuclide physically different from that on the antibody and substraction of the simulated nontarget activity from the nontargeted antibody. A 2-fold increase of the target to nontarget radioactivity is achieved that has made possible a greater than 70% tumor detection rate.
D000912:Antibodies, Neoplasm / Q000008:administration & dosage; D005069:Evaluation Studies as Topic; D006801:Humans; D007457:Iodine Radioisotopes; D008954:Models, Biological; D009369:Neoplasms / Q000000981:diagnostic imaging / Q000276:immunology; D011877:Radionuclide Imaging / Q000379:methods*
D000912:Antibodies, Neoplasm; D007457:Iodine Radioisotopes