Carcinogenic activity of particulate nickel compounds is proportional to their cellular uptake.
Particles (less than or equal to 5 micrometers) of the potent carcinogen crystalline nickel subsulfide were actively phagocytized by cultures of Syrian hamster embryo cells and Chinese hamster ovary cells. Cells did not take up significant quantities of similar-sized particles of the noncarcinogen amorphous nickel monosulfide. The carcinogenic activity of this and other metal compounds appears to be proportional to their cellular uptake.
D000818:Animals; D001692:Biological Transport; D002273:Carcinogens; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004353:Drug Evaluation, Preclinical / Q000379:methods; D004622:Embryo, Mammalian; D005260:Female; D008647:Mesocricetus; D009532:Nickel / Q000378:metabolism* / Q000633:toxicity; D010053:Ovary; D013440:Sulfides / Q000378:metabolism / Q000633:toxicity
D002273:Carcinogens; D013440:Sulfides; D009532:Nickel; C017557:nickel subsulfide