[Effect of kynurenine and its metabolites on the vascular effects of serotonin, noradrenaline, and acetylcholine].
In female albino rats anesthetized with urethane, the depressor effect of serotonin was basically diminished by kynurenine, 3-hydroxyanthranilic acid (3-HAA), and anthranilic acid and was potentiated by quinolinic and picolinic acids (PA). All kynurenines were injected in a dose of 200 micrograms. 3-Hydroxykynurenine and nicotinic acid (NA) had a dual action. The pressor effect of noradrenaline was largely diminished by 3-HAA, PA and NA. Each of the rest kynurenines exerted an opposite action in different experiments. The pressor effect of acetylcholine was not affected by kynurenines.
D015095:3-Hydroxyanthranilic Acid / Q000008:administration & dosage; D000109:Acetylcholine / Q000008:administration & dosage*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004347:Drug Interactions; D005260:Female; D007737:Kynurenine / Q000008:administration & dosage* / Q000031:analogs & derivatives; D009638:Norepinephrine / Q000008:administration & dosage*; D010848:Picolinic Acids / Q000008:administration & dosage; D011805:Quinolinic Acids / Q000008:administration & dosage; D051381:Rats; D012701:Serotonin / Q000008:administration & dosage*; D062367:ortho-Aminobenzoates / Q000008:administration & dosage
D010848:Picolinic Acids; D011805:Quinolinic Acids; D062367:ortho-Aminobenzoates; D015095:3-Hydroxyanthranilic Acid; D012701:Serotonin; D007737:Kynurenine; D000109:Acetylcholine; D009638:Norepinephrine
Vliianie kinurenina i ego metabolitov na sosudistye éffekty serotonina, noradrenalina i atsetilkholina.