Deposition of human labeled platelets to damaged rabbit aorta before and after use of sulfinpyrazone in patients with acute myocardial infarction.
Platelets from patients with acute myocardial infarction were labeled with 51Cr and reconstituted whole blood. The endothelium of rabbit aorta was removed, and segments of the inverted aorta placed on a Plexiglas rod in a perfusion chamber, and the deposition of platelets on the aorta was calculated by radioactivity measurement. In all 8 patients the deposition of platelets was reduced after ingestion of 800 mg of sulfinpyrazone daily for 4 weeks.
D000818:Animals; D001011:Aorta / Q000502:physiology; D001792:Blood Platelets / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D009203:Myocardial Infarction / Q000097:blood* / Q000188:drug therapy; D010477:Perfusion; D010973:Platelet Adhesiveness / Q000187:drug effects*; D011817:Rabbits; D013442:Sulfinpyrazone / Q000494:pharmacology* / Q000627:therapeutic use
D013442:Sulfinpyrazone