title: A fixed combination of hydrochlorothiazide and amiloride for the treatment of essential hypertension.
abstract: The combination of hydrochlorothiazide and amiloride has been used in a group of patients diagnosed as having essential hypertension. Sixty-five percent of the patients for whom dietary restrictions did not achieve a reduction in blood pressure were initially controlled with this combination; the addition of a second or third drug was required by the remaining patients. During the six-month follow-up, the control of blood pressure was satisfactory with increased drug requirements, but the diuretic had to be discontinued in 12 patients because of side effects.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000584:Amiloride / Q000008:administration & dosage* / Q000009:adverse effects; D001774:Blood Chemical Analysis; D001794:Blood Pressure / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D005767:Gastrointestinal Diseases / Q000139:chemically induced; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage* / Q000009:adverse effects; D006943:Hyperglycemia / Q000139:chemically induced; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011719:Pyrazines / Q000008:administration & dosage*; D014527:Uric Acid / Q000097:blood
chemical_list: D011719:Pyrazines; D006852:Hydrochlorothiazide; D014527:Uric Acid; D000584:Amiloride