[Therapeutic effectiveness of neomycin in staphylococcal and Pseudomonas aeruginosa corneal lesions].
Ophthalmic films (OPHF) with neomycin were used in treatment of 15 patients with staphylococcal infections of the cornea. OPHF were effective in treatment of 5 patients with affection of the cornea surface layers. These patients were discharged from the hospital on days 4-5 of the treatment. In the other 10 patients deeper layers of the cornea were affected by the infiltrates and their treatment with OPHF required longer periods (10-15 days). Another 5 patients developed severe keratitis caused by Ps. aeruginosa after removal of foreign bodies from the eyes. These patients were treated with neomycin injections, electrophoresis and OPHF. When the patients received such treatment within the first days of the disease (3 patients), the development of the cornea purulent infection ceased and a favourable therapeutic effect was attained. When neomycin was administered at later periods (2 patients), i.e. 3-4 days after the infection, the treatment was not efffective. It is recommended that broad spectrum antibiotics be used for prevention of the cornea staphylococcal infections after removal of foreign bodies from the cornea surface.
D003316:Corneal Diseases / Q000188:drug therapy*; D004341:Drug Evaluation; D006801:Humans; D009355:Neomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D011552:Pseudomonas Infections / Q000188:drug therapy*; D013203:Staphylococcal Infections / Q000188:drug therapy*; D014792:Visual Acuity / Q000187:drug effects
D009355:Neomycin
Lechebnaia éffektivnost' neomitsina pri stafilokokkovykh i sinegnoĭnykh porazheniiakh rogovoĭ obolochki.