[Enhancement of antitumor resistance by means of small doses of adrenaline].
The antitumor effect of common nonspecific adaptation reactions of training and activation, obtained by small doses of adrenaline, was studied in the experiments on white rats with sarcoma 45,3,4-benz/a/-pyrene induced tumors and Biskind ovary tumor. Total resorption of the tumor was noted in all cases (55 rats), in which histological investigation of the thymus, lymph nodes, endocrinous glands and white cell count evidenced the development of the activation reaction, while with the training reaction there was only some retardation of tumor growth (51 rats). When it proved impossible to overcome a "chronic" tumor stress (45 rats), no antitumor effect was gained. Thus, the reactions of training and activation obtained by small doses of adrenaline (at high level of the organism reactivity) were found to increase the antitumor reaction of the organism.
D000818:Animals; D004702:Endocrine Glands / Q000187:drug effects; D004837:Epinephrine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007962:Leukocytes / Q000187:drug effects; D008198:Lymph Nodes / Q000187:drug effects; D008297:Male; D010051:Ovarian Neoplasms / Q000276:immunology* / Q000473:pathology; D051381:Rats; D012513:Sarcoma, Experimental / Q000276:immunology* / Q000473:pathology; D013312:Stress, Physiological / Q000473:pathology; D013950:Thymus Gland / Q000187:drug effects
D004837:Epinephrine
O povyshenii protivoopukholevoĭ rezistentnosti s pomoshch'iu malykh doz adrenalina.