Increased D-glucaric acid excretion in children with renal disease.
In 85 infants and children, non-specific microsomal enzyme activity was assessed by measuring the urinary D-glucaric acid excretion. In patients with renal disease of various etiology, a highly significant increase in the D-glucaric acid excretion was observed at any early stage of the illness. This change was most marked in patients suffering from tubulopthy and pyelonephritis. Excretion of D-glucaric acid was significantly more pronounced in patients with renal disease than in controls, even in those groups of infants and children who were given enzyme-inducing drugs. As an explanation for the elevation of urinary D-glucaric acid levels in patients with mild renal disease, the possibility and biochemical mechanism of an induction of drug metabolizing enzymes are discussed and some therapeutic conclusions are drawn.
D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D004790:Enzyme Induction / Q000187:drug effects; D005937:Glucaric Acid / Q000652:urine*; D006801:Humans; D007223:Infant; D007674:Kidney Diseases / Q000652:urine*; D013400:Sugar Acids / Q000652:urine*
D013400:Sugar Acids; D003404:Creatinine; D005937:Glucaric Acid