Pharmacological activity of new derivatives of morphine.
Three new derivatives of morphine: O3-(beta-isopropylaminoethyl) ether of morphine (T .3289), O3, O6-[N,N'-bis(methylcarbamate] ester of morphine (T .3298) and beta-dimethylamino-ethyl-ether of dihydromorphinone (T .3403) were tested for their action on CNS. A detailed study of pain threshold, motor activity, conditioned behavior and noradrenaline levels in brain was carried out. The compounds T .3289 and T .3298 exhibited analgesic action. The spontaneous activity of rats was decreased by T .3289 and increased by T .3298. The conditioned avoidance response was decreased and the brain nor-adrenaline levels were altered.
D000700:Analgesics; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001923:Brain Chemistry / Q000187:drug effects; D005260:Female; D051379:Mice; D009022:Morphine Derivatives / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D000700:Analgesics; D009022:Morphine Derivatives