title: Enzyme activities of human myocardium: creatine kinase and hexose phosphate isomerase.
abstract: Creatine kinase (CK) and hexose phosphate isomerase (PHI) activities were determined in 36 samples of human heart muscle obtained from patients during cardiovascular surgery. With one exception, CK activities were higher than any reported so far in the literature (papillary muscle, left ventricle: 2,521 +/- 776 IU/g wet weight at 37 degrees C). PHI Activities, the first time measured, are comparable to those in skeletal muscle (200-400 U/g, higher in papillary muscle than in the right auricle). The activities of both enzymes determined correlate significantly (all samples considered together: r = 0.773; p < 0.001). Results are discussed with respect to their possible clinical interest as well as their significance for myocardial metabolism.
mesh_terms: D000328:Adult; D003402:Creatine Kinase / Q000378:metabolism*; D005260:Female; D005956:Glucose-6-Phosphate Isomerase / Q000378:metabolism*; D006325:Heart Atria / Q000201:enzymology; D006352:Heart Ventricles / Q000201:enzymology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000201:enzymology* / Q000378:metabolism; D010210:Papillary Muscles / Q000201:enzymology
chemical_list: D003402:Creatine Kinase; D005956:Glucose-6-Phosphate Isomerase