A case of centrolobular toxic necrosis of the liver due to aromatic retinoid--Tigason (Ro 10-9359).
A woman aged 54 years developed toxic necrosis of liver cells during treatment with aromatic retinoid (Ro 10-9359) for erythrodermia ichthyosiformis non-bullosa. Her skin was almost normalized when liver function tests and liver biopsy disclosed severe damage. The treatment was stopped, but 4 months later ALAT and ASAT were still elevated.
D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology* / Q000473:pathology; D005050:Etretinate / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007057:Ichthyosis / Q000188:drug therapy; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008875:Middle Aged; D014212:Tretinoin / Q000031:analogs & derivatives*
D014212:Tretinoin; D005050:Etretinate