[Tetraolean pharmacokinetics in the lymph and blood in complicated, acute inflammatory diseases of the abdominal cavity organs].
The time-course of tetraolean concentrations (according to tetracycline) in the lymph, blood and urine of 10 patients with various complicated acute inflammatory diseases of the organs of the abdominal cavity was studied. It was found that tetraolean used intramuscularly in the early postoperative periods was well absorbed into the lymph, reached its maximum level within 2 hours and exceeded that in the blood. During the following 8 hours the concentration of the drug in the lymph decreased but still remained much higher than that in the blood. Lymph sorption lowered the antibiotic lymph level to 30 per cent, which indicated the necessity of an adequate increase in the drug dose.
D000208:Acute Disease; D000327:Adsorption; D000328:Adult; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007700:Kinetics; D008196:Lymph / Q000378:metabolism*; D008875:Middle Aged; D009827:Oleandomycin / Q000378:metabolism*; D010538:Peritonitis / Q000150:complications / Q000378:metabolism* / Q000628:therapy; D013752:Tetracycline / Q000378:metabolism*
D004338:Drug Combinations; D013752:Tetracycline; D009827:Oleandomycin
Farmakokinetika tetraoleana v limfe i krovi pri oslozhnennykh ostrykh vospalitel'nykh zabolevaniiakh organov briushnoĭ polosti.