title: Glucagon suppressed proliferation rate of mammary aplastic carcinoma in mice.
abstract: Glucagon injected into mice with mammary aplastic carcinoma retards the growth and prolongs the mean survival time of the animals. Glucagon stimulates the plaque-forming capacity and phagocytosis in tumor-bearing animals. Cyclophosphamide treatment abolishes the antitumor effect of glucagon, while the effect of the hormone is enhanced in Corynebacterium parvum pretreated animals. It follows that the tumor-retarding effect of glucagon are mediated by mainly by maintaining high B-type reactivity and phagocytosis.
mesh_terms: D000276:Adjuvants, Immunologic; D000818:Animals; D000970:Antineoplastic Agents; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D005934:Glucagon / Q000627:therapeutic use*; D008321:Mammary Glands, Animal / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000401:mortality; D051379:Mice; D010587:Phagocytosis; D011425:Propionibacterium acnes / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D005934:Glucagon