[Antileukemic activity of carminomycin complexes with a high-polymer DNA].
Complexes of carminomycin with DNA were prepared from lyophilized carminomycin and high polymer DNA of sturgeon milt. The complex formation was evident from a batochromic shift in the maxima at 450-600 nm and an increase in the absorption level at 545 nm. The carminomycin complexes with DNA had a relatively low general toxicity and higher antileukemic activity in studies on mice with tumor L-1210 as compared to the use of carminomycin alone. The maximum increase in the average life time of the animals was observed when a complex with a molar ratio of carminomycin and DNA of 1:10 (with respect to nucleotides) was used. It was found that the complex of carminomycin and DNA with a ratio of the components of 1:20 had a more pronounced effect on the animal hemopoiesis as compared to the use of carminomycin alone. It resulted in a more significant decrease in the number of the bone marrow myelokariocytes and peripheral blood erythrocytes and leukocytes.
D000818:Animals; D002360:Carubicin / Q000627:therapeutic use*; D002478:Cells, Cultured; D004247:DNA / Q000627:therapeutic use*; D003630:Daunorubicin / Q000031:analogs & derivatives*; D004338:Drug Combinations; D004353:Drug Evaluation, Preclinical; D066298:In Vitro Techniques; D007939:Leukemia L1210 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy; D007945:Leukemia, Lymphoid / Q000188:drug therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008970:Molecular Weight; D009368:Neoplasm Transplantation
D004338:Drug Combinations; D004247:DNA; D002360:Carubicin; D003630:Daunorubicin
Izuchenie protivoleĭkoznoĭ aktivnosti kompleksov karminomitsina s vysokopolimernoĭ DNK.