Facilitated transport of amino acids across organic phases and the human erythrocyte membrane.
1. An artificial facilitated amino-acid-transfer process operating across a chloroform phase is reported. 2. This process utilizes a family of bis(salicylamidato)copper(II) complexes. 3. A mechanism is proposed for this process and for its sensitivity towards cyanide and bathophenanthroline sulphonate. 4. Facilitated transfer of L-leucine in human erythrocytes has been shown to be inhibited by bathophenanthroline sulphonate.
D000409:Alanine / Q000378:metabolism*; D001692:Biological Transport / Q000187:drug effects; D002725:Chloroform; D003300:Copper; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D004912:Erythrocytes / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D007930:Leucine / Q000378:metabolism*; D008024:Ligands; D008954:Models, Biological; D010618:Phenanthrolines / Q000494:pharmacology; D012457:Salicylamides
D008024:Ligands; D010618:Phenanthrolines; D012457:Salicylamides; C017049:bathophenanthroline disulfonic acid; D003300:Copper; D002725:Chloroform; D007930:Leucine; D000409:Alanine; D005998:Glycine