title: Massive blood transfusion.
abstract: Massive blood transfusion is associated with a wide range of adverse effects, some of which are understood, but controversy surrounds the effects of massive blood loss and transfusion on haemostasis and oxygen transport. Until we have a better understanding of the underlying pathophysiology and while storage of blood remains imperfect, there is a good case for the empirical use of super-fresh blood in this clinical setting. A practical approach to the exsanguinated patient is presented.
mesh_terms: D000137:Acid-Base Imbalance / Q000209:etiology; D001793:Blood Preservation; D002951:Citrates / Q000378:metabolism; D006454:Hemoglobins; D006470:Hemorrhage / Q000628:therapy; D006487:Hemostasis; D006801:Humans; D007035:Hypothermia / Q000378:metabolism; D007565:Jaundice / Q000378:metabolism; D065227:Transfusion Reaction; D014883:Water-Electrolyte Imbalance / Q000209:etiology
chemical_list: D002951:Citrates; D006454:Hemoglobins