Increased toxicity of endotoxin for tumor-bearing mice and mice responding to bacterial pathogens: macrophage activation as a common denominator.
Mice bearing the syngeneic SA-1 sarcoma or treated with live Mycobacterium bovis BCG or Formalin-killed Corynebacterium parvum acquired a greatly increased susceptibility to the lethal effects of endotoxin. In all three experimental models, the acquisition of increased sensitivity to endotoxin was concordant with the generation of a systemically activated macrophage system.
D000818:Animals; D003354:Corynebacterium Infections / Q000276:immunology; D004731:Endotoxins / Q000633:toxicity*; D005260:Female; D008264:Macrophages / Q000276:immunology; D008297:Male; D051379:Mice / Q000276:immunology*; D009164:Mycobacterium Infections / Q000276:immunology; D009374:Neoplasms, Experimental / Q000276:immunology
D004731:Endotoxins