title: Changes in plasma urate, creatinine, alkaline phosphatase and the 24 hours excretion of hydroxyproline during sexual maturation in adolescents.
abstract: The relative concentrations of plasma uric acid and creatinine, the alkaline phosphatase activities and the 24 hour urinary excretion of hydroxyproline together with sexual maturity ratings are reported in a population of normal British schoolchildren studied longitudinally over a three-year period. The children were all of European origin and their ages ranged from 7 to 17 years. Plasma urate rose sharply during puberty in the boys but not in the girls. Plasma creatinine rose in both sexes during maturation. Plasma alkaline phosphatase activity rose to a peak at genital maturity 3(G3) in boys and breast maturity 2(B2) in girls and subsequently fell rapidly in both sexes. The 24-hour urinary secretion of hydroxyproline was high in young boys and rose to a peak during G3 and G4 and then fell rapidly. In girls there was no significant peak in concentrations, although there was a fall during B4 and B5, and levels were higher throughout puberty than those reported for adult females.
mesh_terms: D000293:Adolescent; D000469:Alkaline Phosphatase / Q000097:blood*; D002648:Child; D003404:Creatinine / Q000097:blood*; D005260:Female; D006128:Growth; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D008297:Male; D012737:Sex Factors; D012741:Sexual Maturation; D014527:Uric Acid / Q000097:blood*
chemical_list: D014527:Uric Acid; D003404:Creatinine; D000469:Alkaline Phosphatase; D006909:Hydroxyproline