title: Human fatty marrow aromatizes androgen to estrogen.
abstract: Human female fatty marrow from the femur and iliac crest has the ability to convert androgen to estrogen. Homogenates of fatty marrow incubated with 19-[6,7-3H]hydroxyandrostenedione (19-hydroxyandrost-4-ene-3,17-dione) and an NADPH-generating system produced estrogen in all six samples. The major estrogen produced in five of the cases was [3H]estrone, the immediate product of the aromatizaton of 19-hydroxyandrostenedione. One case produced [3H]estradiol. The local formation of estrogens in bone marrow may be important to the closure of the epiphyses at puberty and may affect osteoporosis at the menopause.
mesh_terms: D000735:Androstenedione / Q000031:analogs & derivatives* / Q000378:metabolism; D001853:Bone Marrow / Q000378:metabolism*; D004958:Estradiol / Q000096:biosynthesis; D004967:Estrogens / Q000096:biosynthesis*; D004970:Estrone / Q000096:biosynthesis; D005260:Female; D006801:Humans; D014316:Tritium
chemical_list: D004967:Estrogens; D014316:Tritium; D004970:Estrone; D000735:Androstenedione; D004958:Estradiol; C011482:19-hydroxy-4-androstene-3,17-dione