Long-term effects of continuous exposure to amphetamine on brain dopamine concentration and synaptosomal uptake in mice.
Continuous release of p-chloroamphetamine from subcutaneously implanted minipumps for 3 days decreased brain 5-hydroxytryptamine, but not norepinephrine or dopamine, when analyzed 2 weeks later. In contrast, 2 weeks after infusion of amphetamine, whole brain dopamine but not 5-hydroxytryptamine or norepinephrine, was decreased. Also, the high affinity uptake of [3H] dopamine was markedly and selectively reduced in striatal synaptosomes. Thus, neurotoxicity is apparently not unique to halogenated amphetamine derivatives, but is produced by amphetamine itself if administered continuously.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000648:ultrastructure; D001923:Brain Chemistry / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D009638:Norepinephrine / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000378:metabolism*; D010133:p-Chloroamphetamine / Q000494:pharmacology
D012701:Serotonin; D010133:p-Chloroamphetamine; D000661:Amphetamine; D004298:Dopamine; D009638:Norepinephrine