Prostaglandin analogues possessing antinidatory effects. 2. Modification of the alpha chain.
Additional double bonds were introduced into the alpha chain in 16-phenoxy-, 16-(3-chlorophenoxy)-, 16-[3-(tri-fluoromethyl)phenoxy]-, and 16-(4-chlorophenoxy)-17,18,19,20-tetranorprostaglandins which have antinidatory effects. Of these analogues, the delta 3-cis-delta 5 analogues 23b is 1200 times more potent than prostaglandin F2 alpha in antinidatory effect in the rat and more potent than any other known prostaglandin analogues.
D000020:Abortifacient Agents, Nonsteroidal; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D010064:Embryo Implantation / Q000187:drug effects*; D005260:Female; D066298:In Vitro Techniques; D011461:Prostaglandins F, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D014590:Uterine Contraction / Q000187:drug effects
D000020:Abortifacient Agents, Nonsteroidal; D011461:Prostaglandins F, Synthetic