Self-catalyzed inactivation of hepatic cytochrome P-450 by ethynyl substrates.
D000114:Acetylene / Q000494:pharmacology; D000480:Alkynes / Q000494:pharmacology*; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D010860:Pigments, Biological / Q000032:analysis; D051381:Rats; D013053:Spectrophotometry; D013329:Structure-Activity Relationship
D000480:Alkynes; D010860:Pigments, Biological; D003577:Cytochrome P-450 Enzyme System; D000114:Acetylene; D010634:Phenobarbital