title: Time-synchronized activation of lipolysis and fatty acids reacylation by bradykinin and angiotensin II in the perfused rabbit kidney.
abstract: BK and AII administered to the isolated perfused rabbit kidney activate two sequential enzymatic processes: 1) a selective release of the PG precursor, AA with concomitant, partial conversion of arachidonate to PGE2. 2) Activation of a reacylation process which leads to decreased release of all fatty acids in the perfusate. There is a lag time of approximately 1 min between initial activation of the arachidonate-specific deacylation reaction that is coupled to PG generation, and subsequent activation of the reacylation process.
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001095:Arachidonic Acids / Q000096:biosynthesis; D001920:Bradykinin / Q000494:pharmacology*; D005227:Fatty Acids / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008053:Lipid Mobilization / Q000187:drug effects*; D008297:Male; D010477:Perfusion; D011458:Prostaglandins E / Q000096:biosynthesis; D011817:Rabbits
chemical_list: D001095:Arachidonic Acids; D005227:Fatty Acids; D011458:Prostaglandins E; D000804:Angiotensin II; D001920:Bradykinin