15-Hydroperoxyeicosatetraenoic acid inhibits human platelet aggregation.
Using human platelets isolated from their plasma, we showed that 15-hydroperoxyu-eicosatetraenoic acid (15-HPETE) inhibits platelet aggregation induced either by arachidonic acid or prostaglandin H2 analog. 15-HPETE does not modify platelet prostaglandin and thromboxane formation from exogenous arachidonic acid but does decrease platelet lipoxygenase activity.
D001095:Arachidonic Acids / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D015289:Leukotrienes; D008054:Lipid Peroxides; D010545:Peroxides / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*; D011453:Prostaglandins / Q000096:biosynthesis* / Q000097:blood; D013931:Thromboxanes / Q000096:biosynthesis / Q000097:blood
D001095:Arachidonic Acids; D015289:Leukotrienes; D008054:Lipid Peroxides; D010545:Peroxides; D011453:Prostaglandins; D013931:Thromboxanes; C025086:15-hydroperoxy-5,8,11,13-eicosatetraenoic acid