Studies of murine complement. Correlation of hypocomplementemia with other disease parameters in individual NZB/W mice and demonstration of anti-complementary material.
We have utilized a new assay for murine complement components to explore the relationship of complement titers to other parameters of disease activity in individual NZB/W female mice. Titers had fallen significantly by 6 months of age, concomitantly with the appearance of antiDNA in serum and of C3 and immunoglobulin in renal glomeruli. The period of hypocomplementemia antedating proteinuria was extremely variable. Heat stable anti-complementary material was found in serum from older NZB/W mice.
D000818:Animals; D003165:Complement System Proteins / Q000172:deficiency*; D005260:Female; D006461:Hemolysis; D006358:Hot Temperature; D007668:Kidney / Q000276:immunology; D051379:Mice; D008813:Mice, Inbred ICR; D008814:Mice, Inbred NZB; D009393:Nephritis / Q000150:complications; D009994:Osmolar Concentration; D011507:Proteinuria / Q000150:complications
D003165:Complement System Proteins