title: Serum lactic acid dehydrogenase and isoenzymes during pregnancy and labor.
abstract: Total serum lactic acid dehydrogenase activity (LDH) and the levels of LDH isoenzymes were investigated in 14 women during early pregnancy (8--16th week), in 28 women during late pregnancy (29--37th week), in 73 at term (38--42nd week) and in 27 during labor (38--42nd week). LDH activity was found to be elevated in severe pre-eclampsia and in chronic hypertensive women during pregnancy as well as during normal and dysfunctional labor. No change was established in total serum LDH during normal pregnancy. LDH 1 was increased during late pregnancy and at term. In severe pre-eclampsia and during normal labor it was decreased. LDH 2 was also decreased in severe pre-eclampsia and during dysfunctional labor. LDH 3 was decreased during late pregnancy but increased in severe pre-eclampsia. No change was observed in LDH 4 during pregnancy, or in labor. LDH 5 was increased in normal and dysfunctional labor.
mesh_terms: D000328:Adult; D005260:Female; D005865:Gestational Age; D006801:Humans; D006973:Hypertension / Q000201:enzymology; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D007743:Labor, Obstetric; D007744:Obstetric Labor Complications / Q000201:enzymology*; D010298:Parity; D011225:Pre-Eclampsia / Q000201:enzymology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000201:enzymology
chemical_list: D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase