The effects of L-ascorbic acid and prostaglandins on isolated tracheal smooth muscle.
On the isolated tracheal smooth muscle, L-ascorbic acid alone induced a dose-related relaxation. When L-ascorbic acid was added in a standard concentration of 10(-5) g/ml to increasing concentrations of PGE2, an increase of relaxation was evident. The opposite effect was observed when PGF2 alpha was added in presence of L-ascorbic acid: a depression of tracheal smooth muscle contraction occurred. L-ascorbic acid increased the relaxing effect of isoprenaline on the tracheal smooth muscle. The relaxation effect of L-ascorbic acid was abolished by propranolol. These data support the hypothesis, that the effect of L-ascorbic acid may be related to stimulation of beta adrenergic receptors.
D000818:Animals; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006168:Guinea Pigs; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D011433:Propranolol / Q000494:pharmacology; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D011461:Prostaglandins F, Synthetic / Q000008:administration & dosage / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects*
D011459:Prostaglandins E, Synthetic; D011461:Prostaglandins F, Synthetic; D011433:Propranolol; D007545:Isoproterenol; D001205:Ascorbic Acid