Nerve growth factors in the rat iris.
Nerve growth factor (NGF) activity was not detected by bioassay in irides killed immediately after excision but NGF appeared within 24 h in living irides placed in culture or grafted to a host eye. Furthermore, sensory and, although less effective, sympathetic denervation of irides in situ led within 10 days to the appearance of NGF activity. In addition, freezing and thawing released a parasympathetic neuronotrophic factor activity from irides.
D000818:Animals; D046508:Culture Techniques; D003714:Denervation; D005615:Freezing; D007498:Iris / Q000294:innervation / Q000378:metabolism* / Q000637:transplantation; D009414:Nerve Growth Factors / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D013564:Sympathetic Nervous System / Q000502:physiology; D013997:Time Factors; D014184:Transplantation, Homologous
D009414:Nerve Growth Factors