title: Plasma concentration and metabolism of phenoperidine in man.
abstract: The plasma concentrations of phenoperidine were measured in five patients during general anaesthesia. The concentration of the drug decreased rapidly between 2 and 40 min and then declined more slowly. Detectable concentrations of phenoperidine were present in plasma for at least 3 h. In the five patients, the distribution half-life of the drug ranged from 3.19 to 14.23 min and the elimination half-life from 47.31 to 162.30 min. Unchanged phenoperidine and two identified metabolites (pethidine and norpethidine) were present in urine.
mesh_terms: D000759:Adjuvants, Anesthesia; D000328:Adult; D000768:Anesthesia, General; D005260:Female; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D010638:Phenoperidine / Q000097:blood / Q000378:metabolism*
chemical_list: D000759:Adjuvants, Anesthesia; D010638:Phenoperidine