title: New tertiary alkaloids of Strychnos decussata.
abstract: From the stem bark of Strychnos decussata (Pappe) Gilg (Loganiaceae), five tertiary indole alkaloids have been isolated and identified. Previously known alkaloids, but new to this plant, were: akagerine (1) and 17-O-methylakagerine (2), while alkaloids newly found in nature were 10-hydroxy-21-O-methylkribine (3a), 10-hydroxyepi-21-O-methylkribine (3b) and 10-hydroxy-17-O-methylakagerine (4). Structures have been ascribed to the new compounds on the basis of their spectral, particularly nmr, data. The pharmacological activity of the alkaloids is also discussed.
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D003292:Convulsants; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010946:Plants, Medicinal / Q000032:analysis*
chemical_list: D000470:Alkaloids; D003292:Convulsants