Increased biosynthesis of specific glycoconjugates in rat corneal epithelium following treatment with vitamin A.
The biosynthesis of corneal epithelial proteins and glycoconjugates and their response to vitamin A were measured in vitamin A-deficient and normal rats. The synthesis of specific high-molecular-weight epithelial glycoconjugates was directly related to the levels of vitamin A administered. Protein synthesis, however, remained unaltered. Since vitamin A is known to reverse the keratinization process, the vitamin A-regulated high-molecular-weight glycoconjugates may play a role in modulating the expression of the keratinizing phenotype.
D000818:Animals; D001345:Autoradiography; D003315:Cornea / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D004848:Epithelium / Q000378:metabolism; D006023:Glycoproteins / Q000096:biosynthesis*; D008970:Molecular Weight; D051381:Rats; D012588:Scintillation Counting; D014212:Tretinoin / Q000008:administration & dosage / Q000494:pharmacology*; D014802:Vitamin A Deficiency / Q000378:metabolism*; D014985:Xerophthalmia / Q000378:metabolism
D006023:Glycoproteins; D014212:Tretinoin