[Cytostatic therapy of GI carcinoma based on assessment of cell kinetics (author's transl)].
Flow cytometry affords an insight into the cell cycle of gastrointestinal tumors. In comparison with the normal GI mucosa, dedifferentiated carcinomas show a large SG2M peak expressing an intense proliferation. The histological examination considers normally only a small part of the tumor, whereas the flow cytometric histogram is based upon a larger amount of cells. Therefore some tumors are regarded as well differentiated by the pathologist, although they have a large SG2M peak. Considering the functioning of cytostatic drugs, all GI tumors should be treated which have a large SG2M peak in flow cytometry.
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002452:Cell Count / Q000379:methods; D003110:Colonic Neoplasms / Q000188:drug therapy*; D006801:Humans; D008938:Mitosis / Q000187:drug effects*; D013274:Stomach Neoplasms / Q000188:drug therapy*
D000970:Antineoplastic Agents
Zellkinetische Untersuchungen bei gastro-intestinalen Carcinomen als Grundlage einer cytostatischen Therapie.