The acute toxicity of butylated hydroxytoluene and its metabolites in mice.
the acute toxicity of butylated hydroxytoluene (BHT) and four of its metabolites, 2,6-di-tert-butyl-4-hydroperoxy-4-methyl-2,5-cyclohexadien-1-one (BHT-OOH), 2,6-di-tert-butyl-4-hydroxy-4-methyl-2,5-cyclohexadien-1-one (BHT-OH), 2,6-di-tert-butyl-p-benzoquinone (DBQ), and 2,6-di-tert-butyl-4-[(methylthio)methyl]phenol (BHT-SCH3) was studied in young male mice following intraperitonel administration. The i.p. LD50 values of BHT, BHT-OOH, BHT-OH, DBQ, and BHT-SCH3 wee 3550, 190, above 1600, 2270, and 1840 mg/kg, respectively. These results suggest that BHT-OOH probably is the most toxic metabolite of BHt.
D000818:Animals; D002084:Butylated Hydroxytoluene / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D008815:Mice, Inbred Strains
D002084:Butylated Hydroxytoluene