title: Effect of 5-hydroxytryptamine and acetylcholine on the energy budget of chickens.
abstract: Intraventricular injections of 5-hydroxytryptamine-HCl (258 nmol) or acetylcholine-HCl (550 nmol) in the chicken caused body temperature to rise at 35 degrees C ambient, a result of decreased evaporative heat loss due to bradypnea. At 10 and 20 degrees C ambient, neither drug affected body temperature. Although these drugs decreased physical activity or shivering or both at 10 and 20 degrees C, metabolic heat production was not depressed enough to alter body temperature significantly. Heart rate decreased simultaneously with decreased activity at 20 degrees C. This study is the first to inject 5-hydroxytryptamine as a salt of HCl, instead of creatinine sulfate, as is commonly used. It is suggested that some of the differences reported herein, compared to other studies, are due to the type of salt used. It is postulated that either 5-hydroxytryptamine or acetylcholine, rather than norepinephrine, may be an important neurotransmitter in the neural pathways for thermoregulation in chickens, even though their action on thermoregulation is minor compared with norepinephrine.
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology*; D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D002645:Chickens / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D009638:Norepinephrine / Q000502:physiology; D012701:Serotonin / Q000494:pharmacology*; D012768:Shivering / Q000187:drug effects
chemical_list: D012701:Serotonin; D000109:Acetylcholine; D009638:Norepinephrine