Attenuation of amphetamine-induced enhancement of learning by adrenal demedullation.
These experiments investigated the effect of immediate posttrial administration of peripherally acting DL-4-hydroxyamphetamine on retention of a one-trial inhibitory avoidance response in intact, adrenal medullectomized, sympathectomized, and medullectomized and sympathectomized rats. In intact rats, 0.82 mg/kg of DL-4-OH-amphetamine enhanced retention performance. In rats sympathectomized by peripheral 6-hydroxydopamine, 24 h prior to training, a lower dose of 4-OH-amphetamine (0.21 mg/kg) was most effective in enhancing retention. Adrenal demedullation abolished the memory enhancing effects of DL-4-OH-amphetamine and also D-amphetamine. These findings suggest that the memory enhancing effects of DL-4-OH-amphetamine and D-amphetamine involve adrenal medullary catecholamines.
D000313:Adrenal Medulla / Q000502:physiology*; D000320:Adrenergic Fibers / Q000187:drug effects; D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D003913:Dextroamphetamine / Q000494:pharmacology; D004837:Epinephrine / Q000378:metabolism; D006892:Hydroxydopamines / Q000494:pharmacology; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects; D010136:p-Hydroxyamphetamine / Q000494:pharmacology*
D000662:Amphetamines; D006892:Hydroxydopamines; D010136:p-Hydroxyamphetamine; D003913:Dextroamphetamine; D009638:Norepinephrine; D004837:Epinephrine