Subacute toxicity of Dietary T-2 toxin in mice: influence of protein nutrition.
The subacute toxic effects of dietary T-2 toxin (20 ppm) incorporated in semipurified diets of 8%, 12% or 16% protein, were examined in young Swiss mice after one, two, three and four weeks. Dietary T-2 toxin caused substantial reductions in growth and food consumptaion, the degrees of which were greatest in mice fed the diets of reduced protein content. T-2 toxin consistently caused similar degrees of nonregenerative anemia, lymphopenia, thymic atrophy and gastric hyperkeratosis irrespective of the dietary protein level. However, erythroid hypoplasia was temporary in mice fed T-2 toxin in the 16%-protein diet such that erythroid precursors regenerated in splenic and bone marrow and were hyperplastic after four weeks. Liver to body weight ratios of mice fed T-2 toxin in the 16%-and 12%-protein diets increased during the four week trial in comparison to control mice fed at a similar rate. These observations indicated that suppression of erythropoiesis in mice by dietary T-2 toxin was temporarty and that the interval before regeneration was prolonged by diets of reduced protein content.
D000821:Animal Feed; D000818:Animals; D001835:Body Weight; D003872:Dermatitis / Q000473:pathology / Q000662:veterinary; D004044:Dietary Proteins / Q000008:administration & dosage / Q000378:metabolism*; D004920:Erythropoiesis; D008297:Male; D051379:Mice; D012376:Rodent Diseases / Q000378:metabolism* / Q000473:pathology; D012717:Sesquiterpenes / Q000633:toxicity*; D013154:Spleen / Q000473:pathology; D013270:Stomach / Q000473:pathology; D013605:T-2 Toxin / Q000633:toxicity*
D004044:Dietary Proteins; D012717:Sesquiterpenes; D013605:T-2 Toxin