Aging and sister chromatid exchange. V. The effect of post-embryonic development on mutagen-induced sister chromatid exchanges in mouse and rat bone marrow cells.
Induction of sister chromatid exchanges (SCE) was examined as a function of post-embryonic development in C57BL/6J mice and Wistar rat bone marrow cells. At low concentrations of three different mutagens, cyclophosphamide, mitomycin C, and doxorubicin, induced SCE levels were not altered with post-embryonic development. However, at higher mutagen concentrations, SCE induction was significantly reduced in growing (3- to 8-week-old) animals when compared to mature (7- to 9-month-old) animals. Studies of 1- to 8-month-old mice at these high doses revealed that mutagen-induced SCE frequencies increase gradually during this period. These results suggest that with post-embryonic development, changes occur in cellular response to mutagen-induced DNA damage.
D000375:Aging; D000818:Animals; D001854:Bone Marrow Cells; D003434:Crossing Over, Genetic / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000494:pharmacology; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL / Q000235:genetics / Q000254:growth & development; D008937:Mitomycins / Q000494:pharmacology; D012854:Sister Chromatid Exchange / Q000187:drug effects
D008937:Mitomycins; D004317:Doxorubicin; D003520:Cyclophosphamide