Antidromic influence on lateral geniculate excitability.
Eighty-four percent of principal cells in the dorsal nucleus of the lateral geniculate body exhibited a transient depression of spontaneous activity following optic tract stimulation. Antidromic corticofugal activity, generated by the evoked cortical field potential, was seen in 21% of the cells studied. In those cells, depression of spontaneous activity lasted an average of 20 msec longer than in those cells where no antidromic activity was present. Longer duration post-stimulus depression of spontaneous activity was often followed by a period of rebound excitation. These findings support the hypothesis that antidromic activity, generated during the evoked response in striate cortex, has a significant influence on excitability pattern of principal cells in the dorsal nucleus of the lateral geniculate body.
D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D005071:Evoked Potentials; D005829:Geniculate Bodies / Q000502:physiology*; D009900:Optic Nerve / Q000502:physiology; D013569:Synapses / Q000502:physiology; D014793:Visual Cortex / Q000502:physiology; D014795:Visual Pathways / Q000502:physiology