Platelet factor 4 regulates osteoclastic bone resorption in vitro.
Platelet factor 4, which inhibits collagenases derived from both human skin and granulocytic extracts, was found to block reversibly parathyroid hormone-stimulated 45Ca release from fetal rat bone in vitro. The inhibitory property was equally effective in both actively resorbing bones and in bones stimulated to initiate resorption.
D000818:Animals; D001779:Blood Coagulation Factors / Q000502:physiology*; D001862:Bone Resorption / Q000187:drug effects*; D005333:Fetus; D010010:Osteoclasts / Q000378:metabolism*; D010281:Parathyroid Hormone / Q000494:pharmacology; D010978:Platelet Factor 4 / Q000502:physiology*; D051381:Rats
D001779:Blood Coagulation Factors; D010281:Parathyroid Hormone; D010978:Platelet Factor 4