title: Effect of haloperidol and pimozide on acetylcholine output from the cerebral cortex in rats and guinea pigs.
abstract: The effect of haloperidol, pimozide and amphetamine on acetylcholine (ACh) output from the cerebral cortex was investigated in unanaesthetized, freely moving and urethane-anaesthetized rats and guinea pigs. Haloperidol (1 mg/kg i.p.) decreased ACh output only in the anaesthetized rats and increased it only in unanaesthetized guinea pigs. Pimozide (1 mg/kg i.p.) stimulated ACh output in unanaesthetized rats and guinea pigs and anaesthetized guinea pigs, but not in anaesthetized rats. Amphetamine (1 mg/kg i.p.) in all cases, stimulated ACh output. In rats with a septal lesion, the effect of amphetamine on ACh output was suppressed but that of pimozide was still present.
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000161:Acoustic Stimulation; D000661:Amphetamine / Q000494:pharmacology; D000758:Anesthesia; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006168:Guinea Pigs; D006220:Haloperidol / Q000494:pharmacology*; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D010868:Pimozide / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
chemical_list: D010868:Pimozide; D007649:Ketamine; D000661:Amphetamine; D006220:Haloperidol; D000109:Acetylcholine