[Study on cefazolin concentration in bone marrow (author's transl)].
Cefazolin (CEZ) concentration in the bone marrow of tibia was examined 1, 2 and 3 hours after intramuscular injection of 1 g. CEZ concentration in the bone marrow of tibia 1 hour after injection was 59.9+/-10.31 microgram/ml. Ratio to serum was 101.7%. CEZ concentration in the bone marrow of tibia 2 hours after injection was 42.5+/-7.77 microgram/ml. Ratio to serum was 102.7%. CEZ concentration in the bone marrow of tibia 3 hours after injection was 33.9+/-7.75 microgram/ml. Ratio to serum was 102.7%. Penetration capacity of CEZ into the bone marrow of tibia was excellent.
D000293:Adolescent; D000328:Adult; D001853:Bone Marrow / Q000378:metabolism*; D002437:Cefazolin / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D002437:Cefazolin