[Inhibitory effect of 18S ribosomal RNA of different origin on a wheat embryo cell-free translation system].
The action of 18S rRNAs from three different sources--mouse reticulocytes, Ehrlich ascite carcinoma cells and wheat embryo--on cell-free translational system derived from wheat embryo was investigated. It is shown that all rRNA preparations have similar inhibitory action on translational activity of the system. This action is not dependent on the source of rRNA and mRNA by which the system is primed. Such a similarity of action strongly suggests a nonspecific mechanism of inhibition which may be based on polyanionic properties of RNA molecules.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000032:analysis; D002474:Cell-Free System / Q000187:drug effects; D003864:Depression, Chemical; D051379:Mice; D014176:Protein Biosynthesis / Q000187:drug effects*; D012334:RNA, Neoplasm / Q000494:pharmacology; D012335:RNA, Ribosomal / Q000302:isolation & purification / Q000494:pharmacology*; D012156:Reticulocytes / Q000032:analysis; D014908:Triticum / Q000032:analysis / Q000378:metabolism*
D012334:RNA, Neoplasm; D012335:RNA, Ribosomal
Ingibiruiushchee deĭstvie 18S ribosomnykh RNK razlichnogo proiskhozhdeniia na beskletochnuiu sistemu transliatsii iz zarodysheĭ pshenitsy.