Increased self-administration of d-amphetamine after destruction of 5-hydroxytryptaminergic neurons.
Rats will initiate self-administration of d-amphetamine and achieve a stable injection rate within 7-10 days. Animals injected intraventricularly with 5,7-dihydroxytryptamine, which selectively destroys 5-hydroxytryptamine-containing neurons, consistently self-injected larger amounts of d-amphetamine from the first day of training, but the acquisition of a stable rate of drug self-administration was not altered. Bilateral microinjection of 5,7-dihydroxytryptamine into nucleus accumbens failed to alter either the acquisition of d-amphetamine self-administration or the maintenance of a stable rate of injection.
D015116:5,7-Dihydroxytryptamine / Q000008:administration & dosage / Q000494:pharmacology; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D003913:Dextroamphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008297:Male; D009474:Neurons / Q000502:physiology*; D009714:Nucleus Accumbens; D051381:Rats; D012055:Reinforcement Schedule; D012646:Self Administration; D012701:Serotonin / Q000502:physiology*
D001679:Biogenic Amines; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D003913:Dextroamphetamine