title: Further studies of effects of vehicles and elicitation concentration in experimental contact sensitization testing in humans.
abstract: Further confirmation of the effects of vehicles and elicitation concentration in experimental contact sensitization testing with fragrance ingredients is reported. A dose-response relation was seen when sensitized human subjects were challenged with dihydrocoumarin, alantroot oil and diethylmalleate. Furthermore, alcohol was shown to be a more effective vehicle than petrolatum, when cinnamon bark oil, vetiver acetate and diethylmalleate were used in predictive tests. The relation of these findings to risk-benefit judgments is discussed briefly.
mesh_terms: D003374:Coumarins / Q000276:immunology; D003877:Dermatitis, Contact / Q000276:immunology*; D000431:Ethanol / Q000276:immunology; D006801:Humans; D007114:Immunization; D007509:Irritants; D008298:Maleates / Q000276:immunology; D009821:Oils / Q000009:adverse effects; D010577:Petrolatum / Q000009:adverse effects; D014677:Pharmaceutical Vehicles / Q000276:immunology*
chemical_list: D003374:Coumarins; D007509:Irritants; D008298:Maleates; D009821:Oils; D014677:Pharmaceutical Vehicles; D000431:Ethanol; D010577:Petrolatum; C014476:diethyl maleate; C026308:3,4-dihydrocoumarin