Renal handling of uric acid in normal and gouty subject: evidence for a 4-component system.
Bidirectional renal urate tranport was studied in both control and gouty subjects. 99.3% of filtered urate undergoes reabsorption as assessed by pyrazinamide suppression of urate secretion. The maximum uricosuric response to benzbromarone, equated with the minimum secretory rate, amounted to 50% of the filtered load in normal persons and was lower in gouty normoproducers. Since benzbromarone selectively inhibits reabsorption of secreted urate, the difference between secreted and excreted uric acid becomes a valid measure of urate reabsorption distal to the secretory site and amounts to 80% of the secreted load in both groups. These data conform to a 4-component model of renal urate handling in man.
D000042:Absorption; D001553:Benzbromarone / Q000494:pharmacology; D001798:Blood Proteins; D005260:Female; D006073:Gout / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism*; D007684:Kidney Tubules / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008954:Models, Biological; D011485:Protein Binding; D011718:Pyrazinamide / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D013696:Temperature; D014527:Uric Acid / Q000378:metabolism*
D001798:Blood Proteins; D014527:Uric Acid; D011718:Pyrazinamide; D001553:Benzbromarone