Renal osteodystrophy in early chronic renal failure.
A bone histological investigation was performed in 20 mondialyzed patients with chronic renal failure and a glomerular filtration rate of 5.1--31.9 ml/min. Osteomalacia was the predominant pathological feature in 60% of the patients, mixed lesion of both osteomalacia and osteitis fibrosa in 30%, and osteitis fibrosa only was seen in 5% of the patients. Only 1 showed normal bone histology. Elevated plasma immunoreactive parathyroid hormone was found in only 1 patient out of 6. The beneficial effect of 1 alpha-hydroxycholecalciferol was recognized in 7 patients, but the drug induced relatively rapid growth of serum creatinine incidentally, when patients had more than 4 mg/dl of serum creatinine.
D000328:Adult; D000368:Aged; D002118:Calcium / Q000097:blood; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D003404:Creatinine / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood
D006887:Hydroxycholecalciferols; D010281:Parathyroid Hormone; D003404:Creatinine; D002118:Calcium; C008088:alfacalcidol