[Effect of sensitization and delayed hypersensitivity reaction on tumor growth in mice].
Mice BALB/c during 8--10 weeks were sensitized by percutaneous injections of BCG vaccine or living B-243 staphylococci weekly, and after 10 days they were inoculated isogenic adenocarcinoma "Akatol". Compared with the control animals the tumor growth was found to be retarded. A more considerable retardation of the growth and in 50% the complete tumor regression was noted in sensitized mice, which repeatedly, since the day of inoculation, were injected subcutaneously or intratumorously alttuberculin or staphylococcic phagolysate, respectively. A gain of the tumor mass was associated with concomitant lessening of skin edema in response to test-allergen injection. Injections of alttuberculin in BCG-sensitized mice C3H/He contribute to an increased cytotoxicity of peritoneal macrophages against the cells of mammary gland isogenic tumor.
D000230:Adenocarcinoma / Q000276:immunology / Q000473:pathology / Q000628:therapy; D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use*; D006968:Hypersensitivity, Delayed; D007167:Immunotherapy; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D013210:Staphylococcus / Q000276:immunology*
D001500:BCG Vaccine
Vliianie sensibilizatsii i allergicheskoĭ reaktsii zamedlennogo tipa na rost opukholi u mysheĭ.