Adrenalectomy prevents hypoxic lung histamine accumulation.
The lung histamine concentration of rats exposed to chronic hypobaric hypoxia was higher than in normoxic sea-level control rats. This hypoxia-induced lung histamine increase was absent in adrenalectomized chronically hypoxic rats. Adrenalectomy, per se, did not influence lung histamine content. The results suggest that the lung histamine content of chronically hypoxic rats is under hormonal control. This control mechanism is not evident under normoxic conditions.
D000311:Adrenal Glands / Q000502:physiology*; D000315:Adrenalectomy; D000818:Animals; D001274:Atmospheric Pressure; D006632:Histamine / Q000378:metabolism*; D000860:Hypoxia / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008297:Male; D051381:Rats
D006632:Histamine