Design of phase II clinical trials in cancer using decision theory.
An application of decision theory to the design of phase II clinical trials in cancer is presented. A risk function which depends on the prior distribution of the response rate, the costs of treating a patient, and the gains or losses resulting from the decision taken upon completion of the study is derived and optimal restricted sampling plans for a response rate of 20% are provided.
D003662:Decision Theory; D004341:Drug Evaluation / Q000379:methods*; D006801:Humans; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy* / Q000191:economics; D012107:Research Design; D012306:Risk; D012494:Sampling Studies