Stereospecific binding of 3H-haloperidol in rat dorsal spinal cord.
[3H]Haloperidol as dopaminergic ligand used on pooled microdiscs punched from the rat dorsal spinal cord allowed detection of a stereospecific binding. Characteristics of such a binding: dissociation constant, Hill's slope and IC50 of different specific drugs were nearly the same as those found in the striatum, which suggests the presence of individualized dopaminergic receptor sites in the rat dorsal horn. Their density (Bmax) is about three times lower than in the whole striatum.
D000818:Animals; D003342:Corpus Striatum / Q000378:metabolism; D006220:Haloperidol / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*; D013237:Stereoisomerism
D011954:Receptors, Dopamine; D006220:Haloperidol