Effect of gamma-oryzanol on serum TSH concentrations in primary hypothyroidism.
A single oral dose (300 mg) of gamma-oryzanol extracted from rice-bran oil produced a significant reduction on the elevated serum TSH levels in hypothyroid patients. Similarly, chronic treatment with gamma-oryzanol resulted in decreased serum TSH levels in 6 of 8 patients. There was no change in the serum levels of thyroxine-iodine and triiodothyronine during the study. In addition, there was no difference in the serum TSH response to TRH in hypothyroid patients and normal subjects. These observations suggest that gamma-oryzanol inhibits serum TSH levels in patients with primary hypothyroidism, possibly by a direct action at the hypothalamus rather than the pituitary.
D000328:Adult; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010666:Phenylpropionates / Q000494:pharmacology* / Q000627:therapeutic use; D013972:Thyrotropin / Q000097:blood*
D010666:Phenylpropionates; D013972:Thyrotropin; C013172:gamma-oryzanol