Scintigraphy with 111In-labeled autologous platelets in venous thromboembolism.
Scintigraphy with 111in-labeled autologous platelets was performed in 20 patients with suspected venous thrombosis and/or pulmonary embolism. The platelets accumulated in venous thrombi in 6 or 7 patients (86%) with positive findings on impedance plethysmography or contrast venography; all 6 were receiving intravenous heparin. In 11 patients with pulmonary embolism diagnosed by ventilation--perfusion imaging or pulmonary angiography, platelet scintigraphy showed embolic uptake only in the one patient not on full-dose heparin. These findings suggest that scintigraphy with 111In-platelets is a promising noninvasive technique for detection of deep venous thrombosis. Heparin does not appear to block localization of labeled platelets in venous thrombi, but may inhibit their adherence to pulmonary emboli.
D000328:Adult; D000368:Aged; D001792:Blood Platelets; D005260:Female; D006801:Humans; D007204:Indium; D007553:Isotope Labeling; D008297:Male; D008722:Methods; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging; D011868:Radioisotopes; D011877:Radionuclide Imaging; D013923:Thromboembolism / Q000000981:diagnostic imaging*; D013924:Thrombophlebitis / Q000000981:diagnostic imaging
D011868:Radioisotopes; D007204:Indium