[Ultrastructure of the contractile myocardium in chronic ischemic heart disease].
The ultrastructure of the contractile myocardium of the left ventricle of the heart in chronic ischemic heart disease was studied in 24 puncture myocardial biopsies. Marked dystrophic changes were revealed in the cell organelles, both in the membrane systems and in the myofibrillary apparatus, which the authors believe were caused by long-term increasing ischemia of the organ. Besides dystrophy, signs of intracellular regeneration were found in some myocytes. These signs were the presence of euchromatin in the nuclei of the myocytes, and increase in the amount of RNA granules and granular sarcoplasmic reticulum in the sarcoplasm. The prevalence of dystrophic changes on the level of the myocyte ultrastructure may be among the causes of cardiac insufficiency in patients with chronic ischemic heart disease.
D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure; D002908:Chronic Disease; D003327:Coronary Disease / Q000473:pathology*; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D008929:Mitochondria, Heart / Q000648:ultrastructure; D009206:Myocardium / Q000648:ultrastructure*; D012519:Sarcoplasmic Reticulum / Q000648:ultrastructure
Ul'trastruktura sokratitel'nogo miokarda pri khronicheskoĭ ishemicheskoĭ bolezni serdtsa.