Effects of altered thyroid state on the inhibition produced by locus coeruleus in Purkinje cells in the rat.
The number of cerebellar Purkinje cells inhibited after locus coeruleus stimulation was found to be greater in hyperthyroid rats than in control healthy animals; these in turn showed a higher percentage of inhibited cells than hypothyroid rats. It is concluded that thyroid hormone is capable of modulating synaptic activity in the LC-PC pathway.
D000818:Animals; D004558:Electric Stimulation; D005260:Female; D006980:Hyperthyroidism / Q000503:physiopathology*; D007037:Hypothyroidism / Q000503:physiopathology*; D008125:Locus Coeruleus / Q000503:physiopathology*; D008297:Male; D011689:Purkinje Cells / Q000502:physiology*; D051381:Rats