Effect of intracisternal butoxamine, a beta-2 adrenoceptor blocking agent, on blood pressure and heart rate in the dog.
The cardiovascular effects of intracisternally administered butoxamine, a beta 2-adrenoceptor blocking drug, were studied in both normotensive and acute hypertensive anaesthetized dogs. Acute hypertension was elicited by sino-aortic denervation (deafferentation). Intracisternal butoxamine (25-400 microgram/kg) failed to decrease blood pressure and reduce heart rate in the two groups of animals. These results show that the decrease in blood pressure elicited by central administration of dl-propranolol is probably not related to central beta 2-adrenoceptor blockade.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D002078:Butoxamine / Q000008:administration & dosage / Q000494:pharmacology*; D002946:Cisterna Magna; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006973:Hypertension / Q000503:physiopathology; D007267:Injections; D008297:Male; D011412:Propanolamines / Q000494:pharmacology*; D013997:Time Factors
D011412:Propanolamines; D002078:Butoxamine