Nicergoline, an anti-aggregating agent which inhibits release of arachidonic acid from human platelet phospholipids.
Nicergoline is an inhibitor of human platelet aggregation induced by many agents. It inhibits platelet prostaglandin production induced by thrombin or collagen but not by arachidonic acid. It abolishes the decrease of platelet phospholipid induced by thrombin. Nicergoline appears as a drug with an antiphospholipase activity of human platelets.
D001095:Arachidonic Acids / Q000097:blood*; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D004873:Ergolines / Q000494:pharmacology*; D006801:Humans; D066298:In Vitro Techniques; D009530:Nicergoline / Q000494:pharmacology*; D010740:Phospholipases / Q000037:antagonists & inhibitors / Q000097:blood; D010743:Phospholipids / Q000097:blood*; D010974:Platelet Aggregation / Q000187:drug effects*; D011458:Prostaglandins E / Q000097:blood; D011460:Prostaglandins F / Q000097:blood; D013929:Thromboxane B2 / Q000097:blood
D001095:Arachidonic Acids; D004873:Ergolines; D010743:Phospholipids; D011458:Prostaglandins E; D011460:Prostaglandins F; D013929:Thromboxane B2; D010740:Phospholipases; D009530:Nicergoline