title: The relationship of bone blood flow, bone tracer deposition, and endosteal new bone formation.
abstract: Bilateral defects of 4.5 by 11 mm were made in the distal one-third of the tibias of eight dogs and unilaterally in four dogs. Bone blood flow was measured by I-Ap washout, tracer deposition of 85Sr was determined, and extraction of 85Sr and [14C]sucrose was measured by the indicator-dilution technique. Endosteal new bone formation was determined by a combined tetracycline-microradiography method. There was a significant correlation between blood flow determined by washout (I-Ap determined over the area of healing bone) and endosteal new bone formation, p < 0.001, expressed as relationships (percent) of the area of new endosteal bone to the total area enclosed by the defect and the medullary cavity of the tibia, p < 0.001. This percentage ranged from 12% to 62% and was directly related to bone blood flow. This suggests that the increase in blood flow in new bone may be secondary to increased metabolic demands.
mesh_terms: D000818:Animals; D001846:Bone Development; D001842:Bone and Bones / Q000098:blood supply*; D004285:Dogs; D011859:Radiography; D013326:Strontium Radioisotopes / Q000378:metabolism*; D013395:Sucrose / Q000378:metabolism; D013977:Tibia / Q000000981:diagnostic imaging / Q000601:surgery
chemical_list: D013326:Strontium Radioisotopes; D013395:Sucrose