[Renal osteodystrophy in children. Therapy with 1,25-dihydroxy-cholechalciferol (author's transl)].
Growth arrest and renal osteodystrophy are major problems in renal insufficiency of children. The present report describes our experiences in managing renal osteodystrophy in 14 dialyzed children using 1,25-DHCC for 12 months. Values in plasma of Ca, P, Mg, alkaline phosphatase, iPTH, 25-OH-D, and 1,25-DHCC were determined regulary. Skeletal X-rays and analysis of iliac crest biopsies were obtained in each child. In treatment with 1,25-DHCC episodes of severe but reversible hypercalcemia occurred. Alkaline phosphatase and iPTH normalized completely. Radiographic examinations revealed marked improvement. Histological signs of fibro-osteoclasia and resorptive defects disappeared but there was no recovery of osteomalacia. A reduction of osteoblast population and of bone transformation was obvious. 1,25-DHCC failed to normalize growth in uremic children. In short, neither vitamin D nor 1,25-DHCC can guarantee complete recovery of renal osteodystrophy and growth arrest in uremic children.
D000293:Adolescent; D002648:Child; D012080:Chronic Kidney Disease-Mineral and Bone Disorder / Q000150:complications / Q000188:drug therapy*; D004100:Dihydroxycholecalciferols / Q000627:therapeutic use*; D006130:Growth Disorders / Q000188:drug therapy; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D006934:Hypercalcemia / Q000139:chemically induced; D006435:Renal Dialysis; D014511:Uremia / Q000150:complications
D004100:Dihydroxycholecalciferols; D006887:Hydroxycholecalciferols
Renale Osteodystrophie bei Kindern Therapieversuch mit 1,25-dihydroxy-cholecalciferol.