Stimulation of granulocyte adhesiveness by the chemotactic peptide N-formyl-L-methionyl-L-phenylalanine.
The in vitro effects of the peptide N-formyl-L-methionyl-L-phenylalanine on granulocytes adhesiveness and chemotaxis were investigated. N-formyl-L-methionyl-L-phenylalanine, when used at concentration chemotactically effective, increased significantly granulocyte adhesiveness. When granulocyte adhesiveness was inhibited by colchicine, the inhibition could not be reversed by subsequent treatment with N-formyl-L-methionyl-L-phenylalanine. These results suggest that microtubular system is involved in the stimulation of granulocyte adhesiveness by N-formyl-L-methionyl-L-phenylalanine.
D002448:Cell Adhesion / Q000187:drug effects; D002630:Chemotactic Factors / Q000494:pharmacology*; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D003078:Colchicine / Q000494:pharmacology; D006098:Granulocytes / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D008715:Methionine / Q000031:analogs & derivatives*; D009239:N-Formylmethionine / Q000031:analogs & derivatives* / Q000494:pharmacology; D009240:N-Formylmethionine Leucyl-Phenylalanine; D009504:Neutrophils / Q000187:drug effects; D009842:Oligopeptides / Q000494:pharmacology*; D013268:Stimulation, Chemical
D002630:Chemotactic Factors; D009842:Oligopeptides; D009239:N-Formylmethionine; D009240:N-Formylmethionine Leucyl-Phenylalanine; D008715:Methionine; D003078:Colchicine