Development of a cardiac antiarrhythmic screening test utilizing theophylline in the rat.
Cardiac arrhythmias were produced in Sprague-Dawley-derived rats by chloroform challenge. The incidence of cardiac arrhythmias so induced increased with age and as a function of dose after pretreatment with theophylline. The dose-response and time-action parameters of theophylline's predisposing action to chloroform-hypoxia-induced cardiac arrhythmias were determined. This information has been utilized to develop a cardiac antiarrhythmic screening test in unanesthetized rats which is presented in the following paper.
D000085:Acetates / Q000494:pharmacology; D000628:Aminophylline / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents; D002725:Chloroform / Q000494:pharmacology; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography; D006339:Heart Rate / Q000187:drug effects; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D051381:Rats; D013806:Theophylline; D013997:Time Factors
D000085:Acetates; D000889:Anti-Arrhythmia Agents; D000628:Aminophylline; D002725:Chloroform; D013806:Theophylline