Clearance of inflammatory cells from the microcirculation of endotoxin-resistant C3H/HeJ mice.
We studied the deposition of platelets and leukocytes in resistant (C3H/HeJ) and sensitive (C3Heb/FeJ) strains of mice challenged intraperitoneally with 1 mg of Salmonella typhi endotoxin, a dose lethal only for the sensitive strain. Comparable degrees of leukopenia and thrombocytopenia were evident at all time periods observed, but in contrast to sensitive mice, leukocytes and platelets were quickly cleared from the pulmonary microcirculation of resistant mice.
D000818:Animals; D001792:Blood Platelets; D002196:Capillaries / Q000166:cytology; D004351:Drug Resistance; D004731:Endotoxins / Q000494:pharmacology*; D007970:Leukopenia; D008168:Lung / Q000098:blood supply*; D051379:Mice; D008809:Mice, Inbred C3H; D009504:Neutrophils; D012485:Salmonella typhi; D013921:Thrombocytopenia
D004731:Endotoxins