Further studies of effects of vehicles and elicitation concentration in experimental contact sensitization testing in humans.
Further confirmation of the effects of vehicles and elicitation concentration in experimental contact sensitization testing with fragrance ingredients is reported. A dose-response relation was seen when sensitized human subjects were challenged with dihydrocoumarin, alantroot oil and diethylmalleate. Furthermore, alcohol was shown to be a more effective vehicle than petrolatum, when cinnamon bark oil, vetiver acetate and diethylmalleate were used in predictive tests. The relation of these findings to risk-benefit judgments is discussed briefly.
D003374:Coumarins / Q000276:immunology; D003877:Dermatitis, Contact / Q000276:immunology*; D000431:Ethanol / Q000276:immunology; D006801:Humans; D007114:Immunization; D007509:Irritants; D008298:Maleates / Q000276:immunology; D009821:Oils / Q000009:adverse effects; D010577:Petrolatum / Q000009:adverse effects; D014677:Pharmaceutical Vehicles / Q000276:immunology*
D003374:Coumarins; D007509:Irritants; D008298:Maleates; D009821:Oils; D014677:Pharmaceutical Vehicles; D000431:Ethanol; D010577:Petrolatum; C014476:diethyl maleate; C026308:3,4-dihydrocoumarin