title: [Induction of cytochrome P-450 and the immune response by free and covalently bound to albumin phenobarbital].
abstract: There is a relationship between the induction of microsomal enzymes and xenobiotic-induced immunological response. Phenobarbital bound with albumin covalently loses the ability to induce the cytochrome P 450-hydroxylase system but acquires an ability to induce the lymphocytic immunological system. This indicates that the two protection systems of the body, hydroxylase and immune ones, can interact with low and high molecular xenobiotics. The cytochrome P 450-hydroxylase system of the liver and other tissues is intended for protection of the body from the action of low molecular hydrophobic compounds. The immunological system is responsible for the organism protection from high molecular compounds.
mesh_terms: D000633:Aminopyrine N-Demethylase / Q000378:metabolism; D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis*; D004912:Erythrocytes / Q000276:immunology; D007109:Immunity / Q000187:drug effects*; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats; D012397:Rosette Formation; D012710:Serum Albumin, Bovine; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000276:immunology; D013268:Stimulation, Chemical
chemical_list: D012710:Serum Albumin, Bovine; D003577:Cytochrome P-450 Enzyme System; D000633:Aminopyrine N-Demethylase; D010634:Phenobarbital
vernacular_title: Induktsiia svobodnym i kovalentno sviazannym s al'buminom fenobarbitalom tsitokhroma P-450 i immunnogo otveta.