Inhibition of acid secretion from vagally innervated and denervated gastric pouches by (Gln4)-neurotensin.
In dogs with innervated fundic pouches an intravenous infusion of (Gln4)-neurotensin, 60 pmol X kg-1 X min-1, reduced the pentagastrin-stimulated acid secretion to 40% of the control secretory rate. After vagal denervation of the fundic pouches the same dose of (Gln4)-neurotensin did not significantly change the secretion. These findings suggest that (Gln4)-neurotensin does not act directly on parietal cells but inhibits acid secretion at a presynaptic level.
D000818:Animals; D003714:Denervation; D004285:Dogs; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D008297:Male; D009496:Neurotensin / Q000494:pharmacology*; D010418:Pentagastrin / Q000494:pharmacology; D012636:Secretory Rate / Q000187:drug effects; D013270:Stomach / Q000294:innervation*; D014630:Vagus Nerve / Q000502:physiology*
D009496:Neurotensin; D010418:Pentagastrin