Dopaminergic inhibition involved in the alpha-naphthoxyacetic acid-induced jumping behavior in mice.
alpha-Naphthoxyacetic acid (alpha-NOAA), one of the retching-inducers, elicited a dose-dependent jumping behavior shortly after i.p. administration in doses ranging from 250 to 700 mg/kg in ddY mice, the incidence of jumping being 97% at a dose of 700 mg/kg. alpha-NOAA also induced hypothermia, retching, head shaking, salivation and lacrimation. Phentolamine, reserpine, disulfiram, tranylcypromine, haloperidol, scopolamine, bicuculline, diazepam and lithium among the drugs tested inhibited to a certain degree but not markedly the alpha-NOAA-induced jumping behavior. However, the behavior was markedly inhibited by a dopaminergic agonist, apomorphine (1 mg/kg, i.p.), and this inhibitory effect was significantly antagonized by a dopaminergic antagonist, haloperidol (2 mg/kg, i.p.). These findings suggest that the jumping behavior elicited by alpha-NOAA may be due to the inhibition of dopaminergic neuron activity.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001831:Body Temperature / Q000187:drug effects; D004298:Dopamine / Q000502:physiology*; D004347:Drug Interactions; D006016:Glycolates / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009281:Naphthalenes / Q000494:pharmacology; D013997:Time Factors
D006016:Glycolates; D009281:Naphthalenes; C018610:1-naphthoxyacetic acid; D004298:Dopamine