Sensitivity of parietal cells to gastrin in the cat: comparison with man and dog.
The ED50 value for exogenous gastrin stimulation of gastric acid secretion in the cat is about 300 pmol kg-1h-1. Comparison with values in man and dog show that the ED50 value for gastrin in man is approximately 6-8 times lower than in cat or dog. The rise in circulating gastrin concentration during infusion of a standard dose of gastrin was 1,340 pg ml-1 in the conscious cat. Comparable studies in man and dog give values of 900 and 300 pg ml-1, respectively. Based on these observations, the sensitivity of the parietal cells to gastrin is in the order man, 1.0; dog, 0.47; and cat, 0.09.
D000818:Animals; D002415:Cats; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism*; D005755:Gastrins / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D013045:Species Specificity
D005755:Gastrins