[Plasma dopamine-beta-hydroxylase activity in pheochromocytoma (author's transl)].
In 3 patients with proved pheochromocytoma, circulating catecholamine concentrations, vanillylmandelic acid and total free catecholamine urinary excretion, dopamine-beta-hydroxylase activities in plasma were measured the day before surgery, during the removal of the tumour and postoperatively. Following the removal of the pheochromocytoma, all these parameters declined with a different rate, possibly related to the half-life proper to each molecule. The results showing a decrease in plasma D beta H activities after the removal of the tumors are in good accordance with most authors. The mechanism and the meaning of catecholamines release from non-innervated tumor-cells remain to be elucidated. By considering these three cases, it does not seem that the evolution of D beta H activity after removal of the tumor is dependent upon the fact that the pheochromocytoma releases preferentially either epinephrine or nephinephrine.
D000310:Adrenal Gland Neoplasms / Q000201:enzymology* / Q000601:surgery; D002395:Catecholamines / Q000097:blood / Q000652:urine; D004299:Dopamine beta-Hydroxylase / Q000097:blood*; D005260:Female; D006801:Humans; D010673:Pheochromocytoma / Q000201:enzymology* / Q000601:surgery; D011184:Postoperative Period; D014642:Vanilmandelic Acid / Q000652:urine
D002395:Catecholamines; D014642:Vanilmandelic Acid; D004299:Dopamine beta-Hydroxylase
Activité dopamine-beta-hydroxylase plasmatique après ablation d'un phéochromocytome. Etude chez trois sujets.