FR-900130, a novel amino acid antibiotic. I. Discovery, taxonomy, isolation, and properties.
A new antibiotic, designated FR-900130, has been discovered in the culture filtrate of Streptomyces. The producing organism has been identified as Streptomyces catenulae. The antibiotic was purified by adsorption onto Duolite C-20, passage through Amberlite IRC-50, final purification and desalting on Sephadex G-25. It shows antimicrobial activity against Gram-positive bacteria and synergy with D-cycloserine. The antibiotic is very labile in alkaline solution above pH 8.0 and decomposed during lyophilization or solvent precipitation. It was converted to an acetyl derivative and the biological properties of the derivative were examined.
D000107:Acetylation; D000613:Aminobutyrates / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000302:isolation & purification / Q000378:metabolism / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D005285:Fermentation; D051379:Mice; D013302:Streptomyces / Q000145:classification / Q000378:metabolism; D014018:Tissue Distribution
D000613:Aminobutyrates; D000900:Anti-Bacterial Agents; C025509:L-2-amino-3-butynoic acid