Detection of tetrodotoxin in autopsy material by gas chromatography.
A gas chromatographic method for the detection of tetrodotoxin in autopsy material is described. The derivative (2-amino-6-hydroxymethyl-8-hydroxyquinazoline, C9-base), which was obtained from tetrodotoxin by alkali treatment, was finally detected by gas chromatography. The mass spectra of the trimethysilylated ( TMS) C9-base are presented together with the result of a gas chromatographic investigation of 8 cases of fatal intoxication.
D001344:Autopsy; D002849:Chromatography, Gas; D006801:Humans; D013058:Mass Spectrometry; D013779:Tetrodotoxin / Q000032:analysis* / Q000506:poisoning
D013779:Tetrodotoxin