The influence of poly(L-lysine) on phospholipid polymorphism. Evidence that electrostatic polypeptide-phospholipid interactions can modulate bilayer/non-bilayer transitions.
31P-NMR shows that poly(L-lysine) binding to cardiolipin, phosphatidylserine or phosphatidylglycerol does not affect the macroscopic structure or local order (in the phosphate region) of the phospholipids. In the case of cardiolipin poly(L-lysine) inhibits the ability of Ca2+ to induce the hexagonal HII phase. Alternatively, poly(L-lysine) induces the hexagonal HII phase for a fraction of the phospholipids in phosphatidylethanolamine-cardiolipin (2:1) dispersions.
D002118:Calcium; D002308:Cardiolipins; D008051:Lipid Bilayers; D008081:Liposomes; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010455:Peptides; D010715:Phosphatidylglycerols; D010718:Phosphatidylserines; D010743:Phospholipids; D011107:Polylysine; D011485:Protein Binding
D002308:Cardiolipins; D008051:Lipid Bilayers; D008081:Liposomes; D010455:Peptides; D010715:Phosphatidylglycerols; D010718:Phosphatidylserines; D010743:Phospholipids; D011107:Polylysine; D002118:Calcium