Combined vs. single-entity pharmacologic inhibition of induced asthma.
The capacity of single oral doses of theophylline, ephedrine and hydroxyzine, alone and in combination, to prevent antigen-induced changes in airways dynamics was compared in patients with seasonal asthma. Each of the individual components was significantly more effective than placebo. Combinations of theophylline-ephedrine and theophylline-ephedrine-hydroxyzine exerted a significantly greater protective effect than the other treatments. Treatment with theophylline-ephedrine-hydroxyzine was associated with fewer side effects than any other treatment, except hydroxyzine alone.
D000328:Adult; D000403:Airway Resistance / Q000187:drug effects*; D000941:Antigens; D001249:Asthma / Q000276:immunology*; D004311:Double-Blind Method; D004359:Drug Therapy, Combination; D004809:Ephedrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D006919:Hydroxyzine / Q000494:pharmacology; D008297:Male; D010919:Placebos; D012129:Respiratory Function Tests; D013806:Theophylline / Q000494:pharmacology
D000941:Antigens; D010919:Placebos; D006919:Hydroxyzine; D013806:Theophylline; D004809:Ephedrine