Analysis of mepivacaine, bupivacaine, etidocaine, lidocaine, and tetracaine.
A GLC method, employing a nitrogen-phosphorus-sensitive detector, is described for the analysis of mepivacaine, bupivacaine, etidocaine, lidocaine, and tetracaine in biological fluids. The method is simple, reliable, and sensitive, with a practical limit of sensitivity of approximately 2.5 ng/ml, well below therapeutic plasma levels. Extensive start-up procedures and sample preparation are not required.
D000083:Acetanilides / Q000032:analysis*; D002045:Bupivacaine / Q000032:analysis*; D002849:Chromatography, Gas / Q000379:methods*; D005041:Etidocaine / Q000032:analysis*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D008012:Lidocaine / Q000032:analysis*; D008619:Mepivacaine / Q000032:analysis*; D013748:Tetracaine / Q000032:analysis*
D000083:Acetanilides; D013748:Tetracaine; D008012:Lidocaine; D008619:Mepivacaine; D005041:Etidocaine; D002045:Bupivacaine