title: The luteal phase defect: the relative frequency of, and encouraging response to, treatment with vaginal progesterone.
abstract: Three hundred and ninety-six patients were evaluated for primary and secondary infertility between December 1976 and May 1979 at a large referral center. Timed late luteal endometrial biopsies were routinely obtained as part of the work-up and were repeated for confirmation if subsequent menses did not occur within 2 days of the expected date. If both biopsies were abnormal, a diagnosis of luteal phase defect (LPD) was made and patients were treated with vaginal progesterone suppositories for a minimum of 6 months. LPD was discovered in 32 of 396 patients (8.1%); among those patients whose infertility was not complicated by other abnormalities, 9 of 13 conceived (70%) and 7 of 13 carried to term (54%). These data suggest an incidence higher than generally recognized and a very encouraging response to replacement therapy.
mesh_terms: D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy*; D008183:Luteal Phase; D011247:Pregnancy; D011374:Progesterone / Q000008:administration & dosage / Q000627:therapeutic use*; D013488:Suppositories; D014621:Vagina
chemical_list: D013488:Suppositories; D011374:Progesterone