Hypothalamic-immune interactions. I. The acute effect of anterior hypothalamic lesions on the immune response.
Rats with electrolytic anterior hypothalamic lesions show changes in lymphoid tissue cellularity and a decrease in the response to concanavalin A (Con A). This effect manifests itself maximally 4 days after lesioning, with a return to normal by day 14. The changes are not mediated through the release of corticosteroids. These data indicate the presence of a neuroendocrine pathway that is capable of modulating immune function.
D000818:Animals; D003345:Corticosterone / Q000097:blood; D007031:Hypothalamus / Q000502:physiology*; D007111:Immunity, Cellular; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008221:Lymphoid Tissue / Q000276:immunology*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D013154:Spleen / Q000166:cytology; D013950:Thymus Gland / Q000166:cytology
D003345:Corticosterone