Measurement of human serum parathyroid hormone in disorders of calcium metabolism and during administration of certain gut hormones.
A sensitive radio-immunoassay for parathyroid hormone (PTH) using the commercially available antisera AS 211/32 and AS 211/41 has been established. The lower limit of sensitivity of the assay is 0,25 ng/ml. Seventy-nine per cent of normal subjects have PTH levels in the measurable range, with a mean of 0,49 ng/ml (SD +/- 0,26 ng/ml). Only 1 of 9 patients with proven primary hyperparathyroidism had a normal serum PTH value. The mean serum PTH value in this group was 3,0 +/- 0,26 ng/ml, which differed significantly from that in the normal group (P < 0,001). The serum PTH level of 33 patients on chronic haemodialysis was uniformly raised, while in 8 patients with hypoparathyroidism PTH levels were undetectable. Patients with malignant disease presented a mixed picture, with raised, normal or undetectable PTH levels. We investigated a possible relationship between the gut hormones, gastrin, secretin and cholecystokinin-pancreozymin (CCK-PK) and PTH secretion in human volunteers. No effect was found, although the investigations were conducted over relatively short time periods.
D000293:Adolescent; D000328:Adult; D002118:Calcium / Q000502:physiology; D002128:Calcium Metabolism Disorders / Q000097:blood*; D005768:Gastrointestinal Hormones / Q000494:pharmacology / Q000502:physiology; D006801:Humans; D006961:Hyperparathyroidism / Q000097:blood; D007011:Hypoparathyroidism / Q000097:blood; D007676:Kidney Failure, Chronic / Q000097:blood; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood* / Q000378:metabolism; D011863:Radioimmunoassay
D005768:Gastrointestinal Hormones; D010281:Parathyroid Hormone; D002118:Calcium