Silybin inhibition of amatoxin uptake in the perfused rat liver.
Silybin dihemisuccinate, in a concentration of 0.4 mg/ml, almost completely inhibited the uptake of an amatoxin by the perfused rat liver. Similary, silybin should also interrupt absorption of toxins due to enterohepatic circulation, e.g. in dog and man. This effect may become important in the therapy of human Amanita poisoning.
D000546:Amanitins / Q000378:metabolism*; D000818:Animals; D003864:Depression, Chemical; D005419:Flavonoids / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D051381:Rats; D012838:Silymarin / Q000494:pharmacology*; D013997:Time Factors
D000546:Amanitins; D005419:Flavonoids; D012838:Silymarin; C018207:amatoxin