[Unusual endoplasmic reticulum formation in liver cells during cholestasis].
The behaviour of cytomembranes of the smooth endoplasmic reticulum (SEP) in the hepatic cells was observed with a special reference to their dependence on bilirubin. Basing on the author's observations and comparing them with the data of the literature, it was possible to conclude that the peculiar formations in the ESR of the liver at cholestasis should be considered as an adaptive demonstration of the hepatic cell to changes occurring in biliary secretion. From morphological point of view, a special variant of the SER cytomembranes, known as glycogenic bodies (GB), is an equivalent to massive cholestasis, and from biochemical point of view (that is more probable) it demonstrates transmission to a reserved metabolic way connecting with the production of glucuronic acid.
D001646:Bile / Q000378:metabolism; D001651:Cholestasis, Extrahepatic / Q000378:metabolism / Q000473:pathology*; D004721:Endoplasmic Reticulum / Q000648:ultrastructure*; D005965:Glucuronates / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure*; D008112:Liver Glycogen / Q000378:metabolism*; D008854:Microscopy, Electron
D005965:Glucuronates; D008112:Liver Glycogen
Neobychnye obrazovaniia éndoplazmaticheskogo retikuluma pechenochnykh kletok pri kholestaze.