Intravesical instillation of adriamycin combined with low-dose irradiation for superficial bladder cancer.
Ten patients with superficial low-grade bladder cancer were treated with intra-vesical instillation of doxorubicin hydrochloride (Adriamycin) with low-dose irradiation (total dose of 800 rads), and the therapeutic effect was evaluated clinically and histopathologically. In clinical evaluation based on cystoscopic findings, all 10 patients showed marked response to the combination therapy. In 3 patients the main tumors disappeared, in 6 the tumors were reduced by 50 per cent or more with or without disappearance of daughter tumors, and in 1 the tumor was reduced by 50 per cent or less with disappearance of daughter tumor. Histopathologically the tumor cells could not be confirmed in 3 patients; the tumor cells were almost nonviable with some viable cells in 2; the tumor cells were almost viable with some nonviable cells in 4; and 1 showed no effect.
D000368:Aged; D002295:Carcinoma, Transitional Cell / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011879:Radiotherapy Dosage; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000628:therapy*
D004317:Doxorubicin