Prediction of survival in head and neck cancer based on leukocyte sedimentation in Ficoll-Hypaque gradients.
A battery of immunologic tests were performed on 42 patients with recurrent cancer of the head and neck whose median survival time was 6.8 months. Two tests correlated with survival: total white blood cell (WBC) count and the percentage of lymphoid cells (%LG) in the Ficoll-Hypaque gradient separated leukocyte fraction of blood. Patients with abnormally low values of %LB had a poor prognosis, as did patients who had greater than 8000 WBC count. Of the variation in %LG, 43% was due to the differences in differential WBC counts among the patients, with the remaining variation attributed to changes in the buoyant densities of the leukocytes. These data suggest that further study of the factors effecting buoyant density of cells may be clinically useful.
D002452:Cell Count; D002499:Centrifugation, Density Gradient; D005260:Female; D006258:Head and Neck Neoplasms / Q000097:blood* / Q000401:mortality*; D006801:Humans; D007962:Leukocytes; D008214:Lymphocytes; D008297:Male; D011379:Prognosis