[Thyroid gland hypofunction and features of musculoskeletal system growth and growth of the body as a whole at an early age].
Chronic injection of mercazolyl to rats aged from 5--7 days to 4 months induces a decrease in motor activity, in the relative and total weight of bones and muscles, in oxygen consumption and cardiac activity. It also leads to hypercholesterolemia associated with a decreased cholesterol level in the skeletal muscle tissue. Abnormal growth and development of the muscles and bones along with a diminished oxygen consumption in rats under one month of age produce a reduction in the body weight as compared to that in control animals. In rats aged from 1 to 4 months the same factors lead to the weight increase accounted for by abnormal oxygent consumption and lipid metabolism. The goitrogenic effec was revealed in young rats chronically administered mercazolyl, this effect was not manifested in 4-month-old rats.
D000110:Acetylcholinesterase / Q000097:blood; D000367:Age Factors; D000818:Animals; D001835:Body Weight; D001846:Bone Development; D002091:Butyrylcholinesterase / Q000097:blood; D002784:Cholesterol / Q000097:blood; D006128:Growth; D006339:Heart Rate; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000503:physiopathology*; D050356:Lipid Metabolism; D009043:Motor Activity / Q000502:physiology; D024510:Muscle Development; D010101:Oxygen Consumption; D051381:Rats
D002784:Cholesterol; D000110:Acetylcholinesterase; D002091:Butyrylcholinesterase
Gipofunktsiia shchitovidoĭ zhelezy i osobennosti rosta skeletno-myshechnoĭ sistemy i organizma v tselom v rannie vozrastnye periody.