Phospholipid release from sonicated vesicles induced by a "critical" fatty acid concentration.
Dipalmitoyl phosphatidylcholine vesicles incubated in the presence of increasing amounts of myristic acid showed a progressive translocation of phospholipid molecules across a dialysis membrane. The rate of phospholipid translocation increased abruptly at a 'critical' value of myristic acid concentrations. The translocation rate of mixed dipalmitoyl phosphatidylcholine/myristic acid vesicles obtained by cosonicating the two components was also dependent on a 'critical' fatty acid concentration. A marked release of K+ and different responses of fluorescent probes to the fatty acid addition were observed at this concentration.
D002850:Chromatography, Gel; D003956:Dialysis; D005227:Fatty Acids / Q000494:pharmacology*; D007700:Kinetics; D008051:Lipid Bilayers / Q000378:metabolism*; D010713:Phosphatidylcholines / Q000378:metabolism*; D010743:Phospholipids / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism
D005227:Fatty Acids; D008051:Lipid Bilayers; D010713:Phosphatidylcholines; D010743:Phospholipids; D011188:Potassium