The effects of bicarbonate on blood coagulation.
The anticoagulant effects of sodium and potassium bicarbonate were investigated with use of fresh human whole blood obtained from normal healthy volunteers. Results from prothrombin and thrombin clotting time determinations demonstrated that bicarbonate can interfere with the clotting process. Clinical data obtained from patients who received intravenous administration of sodium bicarbonate supported these findings.
D000138:Acidosis / Q000188:drug therapy; D000328:Adult; D001639:Bicarbonates / Q000494:pharmacology* / Q000627:therapeutic use; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D006801:Humans; D006863:Hydrogen-Ion Concentration; D011517:Prothrombin Time
D001639:Bicarbonates