A study of the afferent and efferent nerve distribution to the lungs of dogs.
The distribution of afferent and efferent nerves to the lung has been studied using dogs anaesthetised with chloralose in which the lungs had been separated, enabling independent inflation and measurement of lung mechanics. Reflex bronchoconstriction produced by giving an aerosol of 5-hydroxytryptamine (5HT) or histamine to either the right or left lung failed to elicit a change in resistance (RL) of the contralateral lung. In vagotomised dogs, electrical stimulation of the peripheral end of the left or right cervical vagus produced frequency-dependent increases in RL of the ipsilateral lung. Stimulation of the left vagus also produced significant changes in RL of the right lung.
D000344:Afferent Pathways / Q000502:physiology; D000403:Airway Resistance / Q000187:drug effects; D000818:Animals; D001980:Bronchi / Q000187:drug effects / Q000294:innervation; D001985:Bronchial Provocation Tests; D003080:Cold Temperature; D004285:Dogs; D004525:Efferent Pathways / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D006632:Histamine / Q000494:pharmacology; D008168:Lung / Q000294:innervation*; D008176:Lung Volume Measurements; D008297:Male; D009431:Neural Conduction; D010313:Partial Pressure; D012701:Serotonin / Q000494:pharmacology; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D012701:Serotonin; D006632:Histamine