title: Estrogen-induced hyperkeratosis of the nipple.
abstract: Hyperkeratosis of the nipple and areola has been classically divided into three categories: a part of an epidermal nevus, a type associated with ichthyosis, and a nevoid form seen in young women. A case of hyperkeratosis of the nipples in a patient with adenocarcinoma of the prostate treated with diethylstilbestrol is described herein. A possible correlation between estrogens and an acquired form of this rare skin disorder is suggested.
mesh_terms: D000368:Aged; D001940:Breast / Q000187:drug effects*; D002277:Carcinoma / Q000188:drug therapy; D004054:Diethylstilbestrol / Q000009:adverse effects*; D006801:Humans; D007642:Keratosis / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D009558:Nipples / Q000187:drug effects* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000188:drug therapy
chemical_list: D004054:Diethylstilbestrol