A probable model of the inhibitory action of ceruloplasmin on the multiplication of some myxo- and paramyxoviruses.
A model of the interaction between virus glycoprotein and the glycoprotein moeity of ceruloplasmia was developed on the ground of previous experimental data referring to the inhibitory action of this enzyme on the multiplication of some influenza and parainfluenza viruses and on their hemagglutinin and neuraminidase activities. The model makes evident the "trap" action exerted by ceruloplasmin on virus particles, both in the early and in the later phases of virus multiplication.
D002570:Ceruloplasmin / Q000494:pharmacology*; D006023:Glycoproteins / Q000032:analysis; D006389:Hemagglutinins, Viral / Q000032:analysis; D009975:Orthomyxoviridae / Q000187:drug effects*; D010252:Paramyxoviridae / Q000187:drug effects*; D014764:Viral Proteins / Q000032:analysis; D014771:Virion / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D006023:Glycoproteins; D006389:Hemagglutinins, Viral; D014764:Viral Proteins; D002570:Ceruloplasmin