[Variation of serum free amino acids in fulminant hepatitis treated with hepatic assists (author's transl)].
A 10 year old boy, in grade IV hepatic coma, was treated by combination of XAD-4 resin hemoperfusion (HP), activated charcoal HP (Adsorba 300C, Gambro), exchange transfusion by up to 12.0 liters of fresh whole blood, and regular dialysis. Serum free amino acids' values were consecutively assessed during 4 days of treatment. The liver was 490 gr in weight at autopsy and histologic examination revealed cellular necrosis compatible with fulminant hepatitis. Pre-treatment values of alanine, lysine, proline, phenylalanine, arginine, threonine, tyrosine and methionine were increased by 2 to 38 times of normal control, while those of cystine, glutamic acid, serine and glycine were minimally increased up to 1.7 times. Histidine, isoleucine, leucine and valine, on the other hand, were decreased by 20 to 30% and aspartic acid was the lowest at 14% of normal control. The effect of XAD-4 resin HP and exchange transfusion was rather non-specific by decreasing the total amount of amino acids. The molar ratios of branched chain amino acids vs. aromatic amino acids or essential amino were elevated by activated charcoal HP, but, did not reach to normal range.
D000596:Amino Acids / Q000097:blood*; D002648:Child; D005078:Exchange Transfusion, Whole Blood; D006464:Hemoperfusion; D006501:Hepatic Encephalopathy / Q000097:blood* / Q000628:therapy; D006505:Hepatitis / Q000097:blood* / Q000628:therapy; D006801:Humans; D008099:Liver / Q000473:pathology; D008297:Male; D006435:Renal Dialysis
D000596:Amino Acids