The dog prostate under defined hormonal influences: an approach to experimental induced prostatic growth.
The prostate of castrated dogs following treatment with testosterone, dihydrotestosterone and androstanediol combined with 17-beta-estradiol application was analyzed by light microscopic stereology. In all three groups there is a statistically significant increase of prostatic volume and weight. There is a statistically significant increase of the relative and absolute volume of the glandular as well as of the stromal part. Seen by the absolute data there is only a statistically significant increase of the volumetric amount of the smooth muscle cells in the dihydrotestosterone and 17-beta-estradiol treated animals. Regarding tissue distribution there is no difference between the controls and the castrated testosterone and 17-beta-estradiol treated animals. Regarding the stromal part, there is no statistically significant difference between the testosterone and 17-beta-estradiol treated group and the control animals. TIn the androstanediol and 17-beta-estradiol group there is a double and in the dihydrotestosterone and 17-beta-estradiol group a four-fold increase of the stromal part. The synergistic effect of estrogens and androgens on the growth of both parts of the dog prostate--the glandular and stromal compartment--is discussed.
D015113:Androstane-3,17-diol / Q000494:pharmacology*; D000732:Androstanols / Q000494:pharmacology*; D000818:Animals; D002369:Castration; D003238:Connective Tissue / Q000473:pathology; D013196:Dihydrotestosterone / Q000494:pharmacology*; D004285:Dogs; D004958:Estradiol / Q000494:pharmacology*; D008297:Male; D009130:Muscle, Smooth / Q000473:pathology; D009929:Organ Size; D011467:Prostate / Q000187:drug effects* / Q000473:pathology; D013739:Testosterone / Q000494:pharmacology*
D000732:Androstanols; D013196:Dihydrotestosterone; D015113:Androstane-3,17-diol; D013739:Testosterone; D004958:Estradiol