Papillary solute concentrations in acute ureteral obstruction. The effect of prostaglandin inhibition.
Complete unilateral and bilateral ureteral obstruction (24 hr) was produced in rats to evaluate the pathogenesis of the renal concentrating defect. Papillary solute concentration was significantly altered by both. The tissue osmolality of the papilla of the obstructed kidney was depressed to 50% of that found in an unobstructed kidney as a result of a marked reduction in tissue sodium and urea concentrations. No effects on tissue potassium concentration were observed. The administration of indomethacin and meclofenamate did not prevent the derangement in tissue solute concentration produced by obstruction. We conclude that prostaglandins do not seem to contribute to the concentrating defect produced by ureteral obstructions.
D000208:Acute Disease; D000818:Animals; D007671:Kidney Concentrating Ability / Q000187:drug effects*; D008297:Male; D009994:Osmolar Concentration; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D051381:Rats; D014517:Ureteral Obstruction / Q000652:urine*
D011448:Prostaglandin Antagonists