Macro- and micromethods for high-performance liquid chromatographic analysis of oxaprozin in plasma.
A high-performance liquid chromatographic method for the analysis of oxaprozin in the presence of ketoprofen (the internal standard) was developed. Sample preparation involved macro- and microextraction procedures. An octadecylsilane reversed-phase system with an acetonitrile-phosphate buffer (pH 3.9) mobile phase was used to separate the compounds from the extracted plasma components and the oxaprozin metabolites. Linear UV detector response over a wide concentration range resulted in rapid and reproducible quantitation.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000097:blood*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D008832:Microchemistry; D000077431:Oxaprozin; D010080:Oxazoles / Q000097:blood*; D011422:Propionates / Q000097:blood*; D051381:Rats; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D010080:Oxazoles; D011422:Propionates; D000077431:Oxaprozin