[Effect of isoproterenol on adenylate cyclase activity in the adipocytes of rats with spontaneous genetic hypertension].
No differences were found in basal and NaF-stimulated activity of adipocyte adenylate cyclase in intact and adrenalectomized rats with normal blood pressure, as well as in intact and adrenalectomized spontaneously hypertensive rats (SHR). Vmax for isoproterenol-stimulated adenylate cyclase in normotensive and hypertensive rats was similar but Ka of the enzyme in SHR was 3 times higher than in control. Vmax of adrenalectomized rats with normal blood pressure was lowered by 27%, while in SHR adipocytes it was similar to Vmax in intact animals. A conclusion is made about the decreased sensitivity of SHR adipocyte adenylate cyclase to isoproterenol. The role of glucocorticoids in the regulation of enzymatic activity is discussed.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000273:Adipose Tissue / Q000187:drug effects* / Q000201:enzymology; D000315:Adrenalectomy; D000818:Animals; D004789:Enzyme Activation / Q000187:drug effects; D006973:Hypertension / Q000201:enzymology* / Q000235:genetics; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains
D000262:Adenylyl Cyclases; D007545:Isoproterenol
Vliianie izoproterenola na aktivnost' adenilattsiklazy v adipotsitakh krys so spontannoĭ geneticheskoĭ gipertenzieĭ.