The metabolism of 3-chloro-4-fluoro-aniline in dog and rat.
1. 3-Chloro-4-fluorol[14C]aniline, orally administered to a female dog (0.135 mg/kg), was eliminated in the urine as 2-amino-4-chloro-5-fluorophenyl sulphate (83% in 48 h). 2. When 3-chloro-4-fluoro[14C]aniline was administered orally to male rats (ca 2.3 mg/kg), the 0-24 h urine contained 2-amino-4-chloro-5-fluorophenyl sulphate (52% of the aniline dosed), N-(5-chloro-4-fluoro-2-hydroxyphenyl)acetamide (13%) and an unidentified metabolite (16%). 3. 2-Amino-4-chloro-5-fluorophenyl sulphate was identified after extraction as salts by proton and fluorine-19 magnetic resonance spectroscopy. N-(5-Chloro-4-fluoro-2-hydroxyphenyl)acetamide was identified by mass spectrometry and proton magnetic resonance spectroscopy.
D000814:Aniline Compounds / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D002594:Cetylpyridinium; D004285:Dogs; D005243:Feces / Q000032:analysis; D005260:Female; D005965:Glucuronates / Q000378:metabolism; D006868:Hydrolysis; D008297:Male; D051381:Rats; D013045:Species Specificity; D013431:Sulfates / Q000378:metabolism
D000814:Aniline Compounds; D005965:Glucuronates; D013431:Sulfates; C025654:3-chloro-4-fluoroaniline; D002594:Cetylpyridinium