Effects of oxytocin on the isolated vas deferens of the rat.
1 The effect of oxytocin was studied on the isolated vas deferens of the rat. 2 Oxytocin (25 to 200 mu/ml) reversibly reduced the contractile response induced by noradrenaline, dopamine and acetylcholine. 3 Oxytocin (400 mu/ml) abolished the response to potassium. 4 The contractions evoked in the vas deferens by field stimulation were also reduced by oxytocin (50 to 200 mg/ml). The inhibitory effect of the drug was related to the external calcium concentration. 5 It is suggested that oxytocin depresses the contractile responses in the vas deferens at least partly by reducing the availability of calcium from an extracellular source.
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004298:Dopamine / Q000494:pharmacology; D004347:Drug Interactions; D004558:Electric Stimulation; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects; D009638:Norepinephrine / Q000494:pharmacology; D010121:Oxytocin / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D014649:Vas Deferens / Q000187:drug effects* / Q000502:physiology
D010121:Oxytocin; D000109:Acetylcholine; D011188:Potassium; D004298:Dopamine; D009638:Norepinephrine