Effect of ibuprofen or aspirin on probenecid-induced uricosuria.
We dosed eight normal volunteers with single doses of probenecid alone and with aspirin or ibuprofen. Urinary urate clearance was increased by probenecid. This increase was partially inhibited by aspirin but not by ibuprofen.
D000328:Adult; D001241:Aspirin / Q000494:pharmacology*; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D008297:Male; D010865:Pilot Projects; D011339:Probenecid; D014527:Uric Acid / Q000652:urine*
D014527:Uric Acid; D003404:Creatinine; D011339:Probenecid; D001241:Aspirin; D007052:Ibuprofen