A combined treatment with D-amino acids and electroacupuncture produces a greater analgesia than either treatment alone; naloxone reverses these effects.
The D-amino acids (DAA), D-phenylalanine and D-leucine, produce naloxone reversible analgesia; electroacupuncture (EA) also produces analgesia which is blocked by naloxone. Combining the two treatments produces an additive effect with a larger analgesia than that produced by either treatment given alone; this combined effect is also blocked by naloxone. Moreover only 62% of the mice show EA analgesia and 53% show D-amino acid (DAA) analgesia; 80% of the animals show marked analgesia with both EA plus DAA treatment. Perhaps the combination of EA with DAA will provide a potent method for the treatment of clinical pain.
D015670:Acupuncture Therapy; D000698:Analgesia; D000818:Animals; D004558:Electric Stimulation; D005260:Female; D007930:Leucine / Q000627:therapeutic use*; D051379:Mice; D009270:Naloxone / Q000494:pharmacology; D059408:Pain Management; D010649:Phenylalanine / Q000627:therapeutic use*
D009270:Naloxone; D010649:Phenylalanine; D007930:Leucine