[Diazane resistance of leukemia L1210 strain: obtaining and kinetic characteristics of growth].
The diazane (1-2-bis diazoacetylene) resistant strain was obtained by consecutive transplantation of leukemia L 1210 cell from mice, treated by subtherapeutic doses of the drug. The kinetic pattern of development of the primary and resistant strain were analogous. The resistant strain differed from the primary one by a less rate of the growth and more persistant course. Death of mice in both strains occurred under gaining similar thershold number of cells. In both strains a linear dependence was noted between the survival of mice and the logarithm of the transplanted cells number. The time of doubling of the total number of leukemic cells in the organism of mice in the resistant strain was twice as that in the primary one.
D000818:Animals; D003979:Diazonium Compounds / Q000008:administration & dosage / Q000627:therapeutic use*; D004351:Drug Resistance; D007700:Kinetics; D007939:Leukemia L1210 / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D008815:Mice, Inbred Strains; D013386:Succinates / Q000008:administration & dosage / Q000627:therapeutic use*
D003979:Diazonium Compounds; D013386:Succinates; C000279:diazan
Rezistentnyĭ diazanu shtamm leĭkemii L1210. Poluchenie i kineticheskaia kharakteristika rosta.