[Bronchospasms induced by acetylcholin and free running exercise. A comparison in 50 asthmatic children (author's transl)].
Fifty asthmatic children were tested for cholinergic bronchial sensitivity and subjected to a free running exercise test; 92% of them showed hypersensitivity to acetylcholine challenge, and exercise-induced bronchospasm occurred in 80%. On pooling the results, 98% had a positive response to at least one of the tests. Qualitatively, there was a correlation between exercise-induced bronchospasm and bronchial sensitivity to acetylcholin in 38 of the 50 children. Quantitatively, however, no correlation could be found between the severity of the exercise-induced bronchospasm and the threshold dose of acetylcholin. This could be explained by the fact that the non-immunological spasmogenic mechanisms involved in the two tests are different.
D000109:Acetylcholine; D000293:Adolescent; D001249:Asthma / Q000503:physiopathology*; D001250:Asthma, Exercise-Induced / Q000503:physiopathology*; D001986:Bronchial Spasm / Q000139:chemically induced* / Q000503:physiopathology; D002648:Child; D005260:Female; D006801:Humans; D008297:Male
D000109:Acetylcholine
Bronchospasmes induits par l'acétylcholine et par l'exercice. Comparaison chez 50 enfants asthmatiques.