Influence of some irritating or immunostimulating substances on experimental pleurisy in the rat.
Irritating substances, such as turpentine, carrageenan and a reticulo-endothelial system-activating immunostimulant (crude cell walls of Mycobacterium smegmatis), when administered parenterally, inhibit various types of experimental pleurisies. These anti-inflammatory properties may be related to the increase which they induce in serum and pleural exudate levels of haptoglobin and of oxidative activity towards paraphenylenediamine.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents; D003165:Complement System Proteins / Q000378:metabolism; D005122:Exudates and Transudates / Q000187:drug effects; D006242:Haptoglobins / Q000378:metabolism; D007509:Irritants / Q000494:pharmacology*; D008297:Male; D009161:Mycobacterium / Q000276:immunology; D010084:Oxidation-Reduction; D010655:Phenylenediamines / Q000378:metabolism; D010998:Pleurisy / Q000139:chemically induced / Q000378:metabolism*; D051381:Rats
D000276:Adjuvants, Immunologic; D000893:Anti-Inflammatory Agents; D006242:Haptoglobins; D007509:Irritants; D010655:Phenylenediamines; D003165:Complement System Proteins