Thermal decomposition of ibuproxam.
The thermal behavior of ibuproxam was studied at several temperatures, and the degradation products were separated by column chromatography and ethereal extractions. The resulting products were ibuprofen [2-(4-isobutylphenyl)propionic acid], 1-(4-isobutylphenyl)-ethylamine, 4-isobutylacetophenone, and 4-isobutylacetophenone oxime. The compounds were identified by IR, UV, and NMR spectroscopy and elemental analyses. 4-Isobutylacetophenone was treated with hydroxylamine to give 4-isobutylacetophenone oxime.
D000893:Anti-Inflammatory Agents; D044482:Benzeneacetamides; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D006358:Hot Temperature; D006877:Hydroxamic Acids
D000893:Anti-Inflammatory Agents; D044482:Benzeneacetamides; D006877:Hydroxamic Acids; C025377:ibuproxam