Effects of isoproterenol and chlordiazepoxide on drinking and conflict behaviors in rats.
Isoproterenol, a beta-adrenergic agents, induced drinking in water-satiated rats. Isopropeternol exhibited significant anti-conflict activity on water-deprived rats in the Shock-induced Suppression of Drinking (SSD) procedure. Chlordiazepoxide (CDP), at the highest dose tested, also increased drinking in non-deprived naive rats. As expected, CDP demonstrated highly significant anti-conflict activity in thirsty rats (SSD test). These results suggest that in conflict procedures, where food or water is used as a reward, agents that affect the consumatory drive mechanisms could show up as "false positives." Moreover, agents that affect primary drives (e.g., CDP),  in addition to their anti-anxiety activity, could show additive activity in such conflict procedures.
D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D003220:Conflict, Psychological; D003259:Consummatory Behavior; D004327:Drinking Behavior / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D008297:Male; D051381:Rats
D002707:Chlordiazepoxide; D007545:Isoproterenol