[Spasm-activity caused by interaction of benzo- and naphtho-1.3-dioxole-carboxylic acids of mice (author's transl)].
We describe the preparation of 4,7-dimethyl-benzo[1,3]dioxole-5-carboxylic acid (7 d), 5,6-dimethyl-benzo [1,3]dioxole-4-carboxylic acid (14), 6,7-dimethoxy-benzo [1,4]dioxane-5-carboxylic acid (16), 7,8-dimethyl-3,4-dihydro-2 H-benzo [1,5]dioxepin-6-carboxylic acid (17), and of 8,9-dimethyl-2,3,4,5-tetrahydro-benzo [1,6]dioxocin-carboxylic acid (18) by reaction of the lithiumcompounds with carbondioxide. For testing the spasm-activity of benzo [1,3]dioxole-5-carboxylic acids (Table I), benzo [1,3]dioxole-4-carboxylic acids (Table II), and naphtho [1,3]dioxole-carboxylic acids (Table III) these componds were orally given to mice.
D000818:Animals; D001565:Benzoates / Q000138:chemical synthesis / Q000633:toxicity; D004149:Dioxoles / Q000138:chemical synthesis / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D008722:Methods; D051379:Mice; D009281:Naphthalenes / Q000138:chemical synthesis / Q000633:toxicity; D012640:Seizures / Q000139:chemically induced*; D013329:Structure-Activity Relationship
D001565:Benzoates; D004149:Dioxoles; D009281:Naphthalenes
Uber eine durch Benzo- und Naphtho [1.3]dioxolcarbonsäuren an Mäusen erzeugbare Krampfwirkung.