[Effect of large heparin doses on the contractile function, structure and lipid metabolic indices of the myocardium in intact rabbits].
The effect of large doses (700 U/kg daily for 6 days) of heparin on the heart contractile function, myocardial morphology, content of free fatty acids in the blood, and the activity of tri- and monoglycerin lipase in blood plasma and heart tissue of intact rabbits was studied 24, 72 hours and 6 days after the beginning of heparin administration. It was established that the activity of lipolytic enzymes intensified, the concentration of free fatty acids in blood plasma grows, and the myocardial contractility increases after heparin administration. The phase structure of the cardiac cycle is simultaneously disturbed slightly. It is concluded that the intensification of lipolysis plays a role in increasing the myocardial contractility.
D000818:Animals; D004562:Electrocardiography; D004789:Enzyme Activation / Q000187:drug effects; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006321:Heart / Q000187:drug effects*; D006493:Heparin / Q000008:administration & dosage*; D050356:Lipid Metabolism; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000378:metabolism*; D011817:Rabbits; D013997:Time Factors
D005230:Fatty Acids, Nonesterified; D006493:Heparin
Vliianie bol'shikh doz geparina na sokratitel'nuiu funktsiiu, strukturu i nekotorye pokazateli lipidnogo obmena miokarda intaktnykh krolikov.