Alterations in brain norepinephrine metabolism induced by environmental stimuli previously paired with inescapable shock.
Footshock stress produced an immediate increase in brain concentrations of 3-methoxy-4-hydroxyphenylglycol sulfate (MHPG-SO4), a major metabolite of the neurotransmitter norepinephrine, in the rat brain. Twenty-four hours after footshock stress, when concentrations had returned to baseline, increases in MHPG-SO4 and emotional behavior could be elicited by previously neutral environmental stimuli that had been paired with the stress.
D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D001921:Brain / Q000378:metabolism*; D003213:Conditioning, Psychological; D004597:Electroshock; D004777:Environment; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D011187:Posture; D051381:Rats; D013312:Stress, Physiological / Q000378:metabolism*; D013431:Sulfates
D013431:Sulfates; D008734:Methoxyhydroxyphenylglycol; D009638:Norepinephrine