Combination chemotherapy with VM 26 and CCNU in primary malignant brain tumors of children.
13 children with inoperable or recurrent primary malignant brain tumors after previous resection and/or radiotherapy were treated with corticosteroids and a combination of VM 26 and CCNU. There were 10 (78%) patients that responded, 1 with a complete and 9 with a partial response with a median duration of response of 8 months (mean 12.5 months). Toxicity was mainly hematological and of acceptable degree. We recommend combination chemotherapy with VM 26 and CCNU for recurrent primary malignant brain tumors of children.
D000293:Adolescent; D001932:Brain Neoplasms / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008130:Lomustine / Q000008:administration & dosage* / Q000009:adverse effects; D008297:Male; D009607:Nitrosourea Compounds / Q000008:administration & dosage*; D011034:Podophyllotoxin / Q000031:analogs & derivatives*; D013713:Teniposide / Q000008:administration & dosage* / Q000009:adverse effects
D009607:Nitrosourea Compounds; D008130:Lomustine; D013713:Teniposide; D011034:Podophyllotoxin