title: Medullary cardiovascular effects of tetrodotoxin in anaesthetized cats.
abstract: Tetrodotoxin injected in the cat nucleus tracus solitarii produced hypertension without bradycardia, whereas in the nucleus reticularis lateralis it led to hypotension and bradycardia. Tetrodotoxin acts by blocking neuronal activity; it is a useful tool for studying the central organization of cardiovascular regulation. The present data confirm that the nucleus reticularis lateralis is a vasopressive centre.
mesh_terms: D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D002529:Cerebellar Nuclei / Q000187:drug effects; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D008526:Medulla Oblongata / Q000187:drug effects*; D008845:Microinjections; D013779:Tetrodotoxin / Q000494:pharmacology*
chemical_list: D013779:Tetrodotoxin