Glutamate decarboxylase activity in brain regions of differentially-housed mice; a difference in the olfactory bulb.
Glutamate decarboxylase (GAD) activities were determined in homogenates of 8 brain regions of mice that had been differentially housed ("isolated" vs "grouped") for 4--9 weeks. GAD activity was lower in whole forebrains and in olfactory bulbs of isolated mice, changes which might be associated with their increased aggressiveness.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D002262:Carboxy-Lyases / Q000378:metabolism*; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009830:Olfactory Bulb / Q000201:enzymology*; D012934:Social Isolation; D014018:Tissue Distribution
D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase