Hypoglycemic coma, jaundice, and pure RBC aplasia following chlorpropamide therapy.
Five weeks following the initiation of chlorpropamide therapy for diabetes mellitus, hypoglycemic coma, cholestatic jaundice, and RBC aplasia developed in a 41-year-old woman. Within 40 days of stopping the drug, she had made a complete recovery. To our knowledge, this is the first case in which these three complications of chlorpropamide have occurred simultaneously.
D000328:Adult; D000741:Anemia, Aplastic / Q000139:chemically induced*; D002747:Chlorpropamide / Q000009:adverse effects*; D003920:Diabetes Mellitus / Q000188:drug therapy; D003926:Diabetic Coma / Q000139:chemically induced*; D004920:Erythropoiesis / Q000187:drug effects*; D005260:Female; D006801:Humans; D007565:Jaundice / Q000139:chemically induced*
D002747:Chlorpropamide