Transferrin C subtypes and spontaneous abortion.
The transferrin C subtypes were studied in relation to spontaneous abortion and a number of different genetic markers and traits. Among mothers with a history of spontaneous abortion an increased frequency of the C2 gene and especially of the C2 type was found. A correlation was found between the maternal C2 type and the placental alkaline phosphatase variant F, which previously has been shown to be associated with spontaneous abortion. The mechanism behind the intrauterine selection implied is unlikely to be immunological incompatibility between mother and fetus. No association was found with ABO and Rh blood groups, Hp and Gc serum groups, the pregnancy zone protein (PZ), red cell acid phosphatase types and birth weight.
D000026:Abortion, Habitual / Q000235:genetics*; D000328:Adult; D000469:Alkaline Phosphatase / Q000235:genetics; D005260:Female; D005787:Gene Frequency; D006801:Humans; D007231:Infant, Newborn; D011110:Polymorphism, Genetic; D011247:Pregnancy; D012641:Selection, Genetic; D014168:Transferrin / Q000235:genetics*
D014168:Transferrin; D000469:Alkaline Phosphatase