title: Initial experience with Minaxolone. A water-soluble steroid intravenous anaesthetic agent.
abstract: Minaxolone has been used to induce anaesthesia, and in incremental doses to supplement nitrous oxide, in 100 patients undergoing minor surgical procedures. Half the patients received a small dose of fentanyl before induction. Minaxolone proved to be a satisfactory induction agent. The commonest complications were an increase in muscle tone and involuntary muscle movements, which in some patients occurred in the recovery period: their incidence was reduced by fentanyl. There was a notably low incidence of nausea and vomiting.
mesh_terms: D000328:Adult; D000771:Anesthesia, Intravenous; D001285:Atropine / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005283:Fentanyl / Q000494:pharmacology; D006801:Humans; D009609:Nitrous Oxide; D011278:Pregnanes; D011280:Pregnanolone / Q000031:analogs & derivatives; D011674:Pulse / Q000187:drug effects
chemical_list: D011278:Pregnanes; C020413:minaxolone; D001285:Atropine; D011280:Pregnanolone; D009609:Nitrous Oxide; D005283:Fentanyl