Affective illness and HLA frequencies: no compelling association.
114 patients suffering from an endogenomorphic affective illness were typed for HLA antigens at the A and B loci, and the frequencies were compared with those of a control panel numbering 439 individuals. Using new analytical procedures, a large number of tests were conducted, but no convincing evidence for an association of HLA types with affective disorders was obtained. A reanalysis of the same data, where patients are classified according to Danish diagnostic criteria, yields a marginally significant association of the B locus alleles. The sample sizes for this latter analysis were small, the test criteria are undoubtedly inflated, and no compelling case can be made for a useful association.
D000483:Alleles; D001714:Bipolar Disorder / Q000235:genetics*; D005838:Genotype; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D013223:Statistics as Topic / Q000379:methods
D006680:HLA Antigens