Effects of intravenous infusion of CaCl2 on the fibrillation thresholds in rabbits.
A study on the atrial and ventricular fibrillation thresholds performed in urethane anaesthetized rabbits showed that no significant change occurred until blood pressure was reduced to 40% of the initial value. Bilateral cervical vagotomy and the administration of propantheline did not affect these changes. (DL) propranolol (0.2 mg/kg i.v.) "unmasked" a tendency of CaCl2 to elevate the fibrillation threshold; it also increased the lethal calcium level.
D000818:Animals; D001281:Atrial Fibrillation / Q000139:chemically induced*; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000097:blood; D002122:Calcium Chloride / Q000008:administration & dosage*; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006470:Hemorrhage / Q000503:physiopathology; D007263:Infusions, Parenteral; D008297:Male; D008452:Maximum Allowable Concentration; D011433:Propranolol / Q000494:pharmacology; D011817:Rabbits; D014628:Vagotomy; D014693:Ventricular Fibrillation / Q000139:chemically induced*
D011433:Propranolol; D002122:Calcium Chloride; D002118:Calcium