title: High ionic strength: its significance in immunosurveillance against tumor cells in sharks and rays (elasmobranchs).
abstract: It is postulated that the rarity of tumors in elasmobranchs is due to the high ionic strength in their tissues, which is equivalent to a high body temperature. Such conditions should lead to the elimination of variable antigenicity and 100% immune surveillance. The basis for this theory is that the repressor molecular for mitosis, not binding to its operator site cannot bind anywhere.
mesh_terms: D000818:Animals; D008938:Mitosis; D009369:Neoplasms / Q000453:epidemiology / Q000662:veterinary*; D009994:Osmolar Concentration; D012754:Sharks / Q000097:blood / Q000502:physiology*