[Neutralization of ammonia in cardiac muscle].
The pathways of ammonia neutralization in the rat heart muscle were traced with nitrogen-15 isotope. The effect of ammonia concentration in the perfusate on its utilization by the myocardium was investigated over the range of 1.6--3.4 mM. Considerable amounts of the neutralized ammonia were found in glutamine and glutamic acid, less quantities in alanine and aspartic acid. Isoproterenol-induced necrosis of the heart muscle leads to a decrease in both glutamine and alanine ability to bind ammonia (20--40 and 30--45%, respectively). The necrosis effect is not significant for glutamic acid. In necrosis nitrogen-15 incorporation into aspartic acid declines whereas with higher concentrations it significantly increases.
D000409:Alanine / Q000378:metabolism; D000641:Ammonia / Q000378:metabolism*; D000818:Animals; D001224:Aspartic Acid / Q000378:metabolism; D009202:Cardiomyopathies / Q000139:chemically induced / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism; D005973:Glutamine / Q000378:metabolism; D007545:Isoproterenol; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D009336:Necrosis; D051381:Rats
D005971:Glutamates; D005973:Glutamine; D001224:Aspartic Acid; D000641:Ammonia; D007545:Isoproterenol; D000409:Alanine
Neĭtralizatsiia ammiaka v serdechnoĭ myshtse.