[Effect of Kupffer cell blockade on the development of acute toxic hepatitis].
The blockade of Kupffer cells was induced in Wistar rats by intravenous injection of colloid iron, brand P-100 phi, in a 5% starch followed after two hours by subcutaneous administration of 0.2 ml of 40% CCl per 100 g body weight. During the blockade of course of CCl4-induced acute hepatitis was significantly modified that was shown by the tendency to scattering of hepatocyte injury and by delayed liver tissue recovery.
D000208:Acute Disease; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000209:etiology; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003102:Colloids; D007501:Iron / Q000494:pharmacology; D007728:Kupffer Cells / Q000187:drug effects*; D008115:Liver Regeneration / Q000187:drug effects; D051381:Rats; D013997:Time Factors
D003102:Colloids; D007501:Iron
Vliianie blokady kletok Kupfera na razvitie ostrogo toksicheskogo gepatita.