[Serum gastrin: interests and limitations of radio-immunoassay (author's transl)].
Radio-immunoassay of serum gastrin may now be carried out in all laboratories of radio-immunology. Comparison of two commercial kits A: Schwartz-Mann and B: CEA-SORIN according to criteria of specificity, sensitivity and reproducibility within and between systems, shows that they both permit the detection of pathological hypergastrinemias (Zollinger Ellison and atropic gastritis). Both kits have an identical intra-system coefficient of variation (10 p. cent and 7 p. cent for A, 5 p. cent and 8 p. cent for B) on the other hand, the inter-system coefficient of variation is better for kit B (22,4 p. cent and 37 p. cent for kit A, and 11,5 p. cent and 14,2 p. cent for kit B). The normal values for each kit are quite different: 97 + 64 pg.ml-1 for A and 51 . 23 pg.ml-1 for B preventing one from comparing estimations carried out with two different kits.
D000236:Adenoma / Q000097:blood; D005069:Evaluation Studies as Topic; D005755:Gastrins / Q000097:blood*; D011863:Radioimmunoassay / Q000379:methods; D012016:Reference Values; D015043:Zollinger-Ellison Syndrome / Q000097:blood
D005755:Gastrins
Gastrine sérique: intérêt et limites du dosage radio-immunologique.