Gastrin injected into the lateral hypothalamus stimulates secretion of gastric acid in rats.
Intrahypothalamic injections of 100 picomoles of pentagastrin or natural gastrin promptly increased secretion of gastric acid in conscious rats. The response was blocked by atropine and by vagotomy. The same doses, injected intravenously or into other forebrain sites, did not increase secretion, nor did intrahypothalamic injections of other peptides common to the gut and brain.
D000818:Animals; D005750:Gastric Juice / Q000378:metabolism*; D005755:Gastrins / Q000494:pharmacology*; D007031:Hypothalamus / Q000187:drug effects* / Q000502:physiology*; D008297:Male; D010418:Pentagastrin / Q000097:blood / Q000494:pharmacology; D051381:Rats; D013268:Stimulation, Chemical
D005755:Gastrins; D010418:Pentagastrin