Serum and cerebrospinal fluid proteins in tuberculous meningitis.
Serum and CSF protein electrophoresis was performed on cellulose acetate in 8 controls and 30 cases of tuberculous meningitis before treatment and during a hospitalization period of 5 months. The analysis of the CSF electrophoretic pattern showed that abnormalities in the prealbumin, beta and gamma fractions may still exist as late as 5 months after initiation of treatment. An increase in alpha 2 and decrease in the albumin fractions in the serum also persisted. Treatment for 20 weeks improved the clinical condition of the patients and resulted in a significant improvement in the CSF prealbumin and alpha 1 fractions. These findings indicate that changes in these fractions may be considered a good prognostic aid.
D000293:Adolescent; D000328:Adult; D001798:Blood Proteins / Q000032:analysis*; D002556:Cerebrospinal Fluid Proteins / Q000032:analysis*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012293:Rifampin / Q000008:administration & dosage; D013307:Streptomycin / Q000008:administration & dosage; D013997:Time Factors; D014390:Tuberculosis, Meningeal / Q000175:diagnosis* / Q000188:drug therapy
D001798:Blood Proteins; D002556:Cerebrospinal Fluid Proteins; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin