[Stimulation of esophageal motility with bromoprid, domperidon and metoclopramide. Therapy of esophageal reflux disease].
This double-blind and cross-over study was designed to compare the effect of domperidon, metoclopramide and bromopride on esophageal motility. A stimulating effect on lower esophageal sphincter pressure (LESP) was shown after i.v. bolus of all three substances, not after saline (control period). LESP was rised significantly up to 50 min above basal levels. Motility pattern of the esophagus was also stimulated up to 50 min.
D000328:Adult; D001562:Benzimidazoles / Q000627:therapeutic use*; D004294:Domperidone; D004943:Esophagogastric Junction / Q000187:drug effects; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008787:Metoclopramide / Q000031:analogs & derivatives* / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*
D001562:Benzimidazoles; D010880:Piperidines; D004294:Domperidone; C013855:bromopride; D008787:Metoclopramide
Stimulierung der Osophagusmotilität durch Bromoprid, Domperidon und Metoclopramid Zur Therapie der ösophagealen Refluxkrankheit.