C-peptide uptake and excretion by the liver in man.
The hepatic uptake of C-peptide is believed to be negligeable; this, however, is based on indirect evidence. In the present work, C-peptide was measured in four non obese non diabetic men stimultaneously in portal blood and bile. Small amounts of C-peptide were found in bile, compared with portal levels; these data are consistent with a minor role of the liver in C-peptide metabolism but represent a direct demonstration of an extraction of the peptide by the liver in man.
D000328:Adult; D000368:Aged; D001646:Bile / Q000378:metabolism; D002096:C-Peptide / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000378:metabolism*
D002096:C-Peptide; D010455:Peptides