title: Assessment of regional blood flow by intravenous injection of 99m-technetium-pertechnetate.
abstract: A general method for computation of regional blood flow from time-activity curves obtained after intravenous injection of 99m-TC pertechnetate is presented. The method is based on the well-known principle of Meier and Zierler, but, it also considers the dispersion of an intravenously injected activity-bolus as well as the recirculation of the nondiffusible tracer. The problems arising from the use of a nondiffusible indicator concerning the partition coefficient lambda are discussed. This method of blood flow determination is adopted for measurements of cerebral blood flow and some first results are discussed.
mesh_terms: D000328:Adult; D000368:Aged; D002560:Cerebrovascular Circulation; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D012039:Regional Blood Flow; D013667:Technetium / Q000008:administration & dosage
chemical_list: D013667:Technetium