Age-associated changes in deoxyglucose uptake in whole brain.
Cerebral blood flow, studied by means of a diffusible indicator, remains unchanged in the aging process (developmental changes). On the contrary, brain activity, evaluated by deoxyglucose uptake, is significantly reduced. Papaverine, which increases cerebral blood flow, and vincamine, slightly but significantly, act on this parameter in the older animals.
D000375:Aging; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D003847:Deoxyglucose / Q000097:blood; D010208:Papaverine / Q000494:pharmacology; D051381:Rats; D014749:Vincamine / Q000494:pharmacology
D001786:Blood Glucose; D014749:Vincamine; D003847:Deoxyglucose; D010208:Papaverine