[Demonstration of hepatitis Be-antigen and of antibodies against it (author's transl)].
Results of demonstrating HBe-antigen and anti-HBe antibodies by radioimmunoassay and by rheophoresis were compared. The former method was more sensitive by a factor of 500 in demonstrating HBe-antigen. Results were not reproducible in 1.14% of cases. Radioimmunoassay makes it possible to demonstrate HBe-antigen or anti-HBe in 90% of HBs-antigen containing sera from patients with hepatitis B or chronic liver damage, and in drug addicts or blood donours. With rheophoresis positive results were obtained in less than 10%. Early seroconversion from HBe-antigen to anti-HBe was demonstrated in patients with hepatitis B. Seroconversion was delayed in drug addicts. Persistence of HBe-antigen for 1-2 years was noted in some cases.
D000914:Antibodies, Viral / Q000032:analysis*; D001782:Blood Donors; D006509:Hepatitis B / Q000276:immunology; D006510:Hepatitis B Antibodies / Q000032:analysis*; D006511:Hepatitis B Antigens / Q000032:analysis*; D006801:Humans; D008107:Liver Diseases / Q000276:immunology; D011863:Radioimmunoassay; D019966:Substance-Related Disorders / Q000276:immunology
D000914:Antibodies, Viral; D006510:Hepatitis B Antibodies; D006511:Hepatitis B Antigens
Der Nachweis von Hepatitis-Be-Antigen und von Antikörpern gegen Hepatitis-Be-Antigen.