title: Effects of nafenopin, diphenylhydantoin, phenobarbitone and some acetylenes on body composition: is there a relationship between decreased carcass lipid and increased liver size and induction of drug metabolizing enzymes?
abstract: Administration of nafenopin, diphenylhydantoin, phenobarbitone or the acetylenes BRL 15268 and BRL 19001 in the diet or, in the case of phenobarbitone, in drinking water reduced the body-lipid content of genetically-obese (ob/ob) mice. These compounds also reduced food intake in ob/ob mice. However, dietary restriction had less effect on body-lipid content than did the compounds. Nafenopin, diphenylhydantoin and BRL 15268 reduced the body-lipid content of normal mice and had no effect on food intake. Each of the compounds that reduced body-lipid content increased the liver weight of normal and ob/ob mice. BRL 15268 and BRL 19001 increased the maximum activity of NADPH oxidase in liver. It is proposed that these reductions in body-lipid content result from the increased metabolic rate involved in enlarging the liver and maintaining its increased size.
mesh_terms: D000114:Acetylene / Q000494:pharmacology*; D000480:Alkynes / Q000494:pharmacology*; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D055598:Chemical Phenomena; D002621:Chemistry; D004435:Eating / Q000187:drug effects; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D051379:Mice; D008820:Mice, Obese; D009255:Nafenopin / Q000494:pharmacology*; D009929:Organ Size / Q000187:drug effects; D010101:Oxygen Consumption; D010634:Phenobarbital / Q000494:pharmacology*; D010672:Phenytoin / Q000494:pharmacology*; D011422:Propionates / Q000494:pharmacology*
chemical_list: D000480:Alkynes; D011422:Propionates; D009255:Nafenopin; D010672:Phenytoin; C026036:BRL 19001; C026035:BRL 15268; D000114:Acetylene; D010634:Phenobarbital