A cardiac antiarrhythmic screening test in the rat: the effects of lidocaine, propranolol and quinidine.
The dose-response and time-action parameters for the prototype antiarrhythmic drugs lidocaine, propranolol and quinidine were established using a cardiac antiarrhythmic screening procedure in the rat. This simple screening procedure produces severe cardiac arrhythmias, primarily ventricular fibrillation, in young post-weaning rats which have been pretreated with a single intramuscular injection of theophylline (20 mg/kg) 15 to 45 min prior to their inhalation of chloroform vapors.
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D007928:Lethal Dose 50; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D011433:Propranolol / Q000494:pharmacology*; D011802:Quinidine / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D008012:Lidocaine; D011433:Propranolol; D011802:Quinidine