Sickle cell retinopathy.
Ten percent of North American blacks have one of four forms of sickle cell disease. Eight to nine percent have sickle cell trait (AS disease); One-half to one percent have SThal disease; Four-tenths percent have SS disease; One-tenth to three-tenths percent have SC disease. The SC and SThal forms present with the most frequent and severe ocular manifestations, including proliferative and non-proliferative retinopathies. Approximately 1% of the black population is at risk for serious ocular complications. The purpose of this paper is to familiarize the reader with the retinal signs, transmissibility, and pathophysiology of a high incidence disease. Early recognition and referral results in prolonged visual function if proper therapy is undertaken. A brief overview of ocular therapies is included.
D000328:Adult; D000755:Anemia, Sickle Cell / Q000453:epidemiology / Q000473:pathology* / Q000628:therapy; D044383:Black People; D005260:Female; D006451:Hemoglobin, Sickle / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009656:North America; D012164:Retinal Diseases / Q000473:pathology* / Q000628:therapy; D012805:Sickle Cell Trait / Q000473:pathology*
D006451:Hemoglobin, Sickle