Spontaneous variability of Streptomyces glomeratus, a producer of the amthracycline antibiotics beromycins.
Spontaneous variants of the beromycin-producing strain Streptomyces glomeratus 3980 were divided into five groups (A-E) according to increasing antibiotic activity. The most active variants (group E) differed from the other types and the wild strain by a suppressed ability to produce aerial mycelium and melanoid piogment and by an increased production of propionic acid. Strains with a 12-fold higher antibiotic production capacity (with respect to strain 3980) were obtained by selection of superior segregants from submerged cultures of the E type.
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis*; D014644:Genetic Variation; D009279:Naphthacenes / Q000096:biosynthesis; D010860:Pigments, Biological / Q000096:biosynthesis; D011422:Propionates / Q000096:biosynthesis; D013302:Streptomyces / Q000166:cytology / Q000235:genetics / Q000378:metabolism*
D018943:Anthracyclines; D000903:Antibiotics, Antineoplastic; D009279:Naphthacenes; D010860:Pigments, Biological; D011422:Propionates; C017065:beromycin, anthracycline