Effects of electrical stimulation on the enkephalins in guinea-pig small intestine.
When myenteric plexus-longitudinal muscle preparations of the guinea-pig small intestine are stimulated electrically in the presence of cycloheximide there is a decrease in the content of enkephalins which is taken to be due to their release. With supramaximal stimuli, the release per pulse is similar at 1 and 10 Hz but it is lower with submaximal than with maximal stimuli. Met-enkephalin is more readily released than Leu-enkephalin.
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D004558:Electric Stimulation; D004723:Endorphins / Q000378:metabolism*; D004745:Enkephalins / Q000378:metabolism*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000378:metabolism*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009197:Myenteric Plexus / Q000378:metabolism*; D013997:Time Factors
D004723:Endorphins; D004745:Enkephalins; D003513:Cycloheximide