The effect of naloxone on psychotropic drug-induced prolactin, growth hormone and cortisol secretion--a preliminary report.
In the course of studies of the effects of interaction between opiate receptors and psychotropic drugs, plasma hormone levels were measured in a group of psychiatric patients on steady-state antidepressant or neuroleptic drugs following intravenous naloxone administration. Plasma prolactin levels were depressed after 10 minutes but at 1 hour rebound elevation was observed in some subjects. Plasma growth hormone and cortisol levels were elevated from 10 minutes to 1 hour following naloxone. These results are discussed with respect to the possible mode of action of psychotropic drugs. In a volunteer given oral clomipramine a marked reduction of the plasma level of the drug was observed following the insertion of an indwelling cannula kept patent with citrate. The use of this technique to study the effect of drugs, especially in single-dose volunteer studies, calls for further critical evaluation.
D000328:Adult; D002997:Clomipramine / Q000097:blood / Q000494:pharmacology; D004347:Drug Interactions; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D008297:Male; D009270:Naloxone / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D013997:Time Factors
D011619:Psychotropic Drugs; D009270:Naloxone; D011388:Prolactin; D013006:Growth Hormone; D002997:Clomipramine; D006854:Hydrocortisone