Preparation and antitumor activity of olivomycin A analogues.
Novel analogues of olivomycin A were prepared by selective reactions involving the carbonyl and hydroxyl groups of the aglycon moiety. Electrophilic substitution of the aglycon also was successful. Of 11 analogues, all but two were active in the P-388 murine leukemia assay. One compound, the 2'-methoxime, showed superior activity to olivomycin A based on its wider dose range and greater potency. The methyl imine and the 8-O-methyl ether were equal to olivomycin A in potency and efficacy. Most of the other analogues were slightly less potent or effective.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000138:chemical synthesis*; D004247:DNA / Q000378:metabolism; D005260:Female; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D009848:Olivomycins / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000903:Antibiotics, Antineoplastic; C025047:olivomycin A; D009848:Olivomycins; D004247:DNA