title: [Delayed allergic nasal reactions. (Synonyms: Coombs and Gell's type IV, delayed hypersensitivity, allergy of the tuberculin and eczema type). Studies on the morphology and pathogenesis].
abstract: Synonyms: cell-mediated allergy, delayed-type reaction, allergy of type IV according to Coombs and Gell), investigations into morphology and pathogenesis. The tuberculin reaction in guinea pigs was used as test model. Rhinorheomanometric studies supplemented by rhinoscopic and histological findings have provided evidence that an allergy of type IV in the Coombs and Gell classification can be provoked the nasal mucous membrane. It is also shown that the allergen quantities used in the intranasal challenge test can also react with the nasal mucosa under normal life conditions. Thus the provoked symptoms are similar to those of another disease already defined but under another name. Critical assessment of test results, immunological literature and the analysis of some delayed reaction challenge tests in human medicine are the reason for assuming clinical symptoms of hypertrophy probably preceding ozena to be the clinical correlation to a type IV reaction.
mesh_terms: D000485:Allergens; D000818:Animals; D004306:Dose-Response Relationship, Immunologic; D006168:Guinea Pigs; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D009297:Nasal Mucosa / Q000276:immunology* / Q000473:pathology; D009299:Nasal Provocation Tests; D012222:Rhinitis, Atrophic / Q000209:etiology; D014373:Tuberculin / Q000276:immunology
chemical_list: D000485:Allergens; D014373:Tuberculin
vernacular_title: Allergische Spätreaktion in der Mase (Synonyma: Typ IV nach Coombs und Gell, Delayed hypersensitivity, Allergie vom Tuberkulin- und Ekzemtyp) Untersuchungen zur Morphologie und Pathogenese.