Aprindine psychosis.
A young woman with mitral valve prolapse and ventricular tachycardia refractory to numerous antiarrhythmics, received a trial of aprindine. During the course of treatment she developed a severe psychotic reaction that resolved after the drug was stopped. Her psychosis was unassociated with the other dose-related neurological side effects of aprindine, and occurred at borderline therapeutic levels of the drug.
D000328:Adult; D001073:Aprindine / Q000009:adverse effects* / Q000627:therapeutic use; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D005260:Female; D006801:Humans; D007192:Indenes / Q000009:adverse effects*; D011605:Psychoses, Substance-Induced
D007192:Indenes; D001073:Aprindine