Non-invasive evaluation of left ventricular function through systolic time intervals following oral administration of SB 7505 in man.
An investigation on the effect of diisobutyric ester of N-methyl-dopamine (SB 7505) on systolic time intervals (STI), heart rate (HR), systolic arterial pressure (SAP), diastolic arterial pressure(DAP), saluretic activity was carried out on 8 male volunteer in-patients who had normal renal, gastrointestinal, cardiac and hepatic functions and were free from other serious illness. SB 7505 was administered orally at three doses of 50, 100 and 150 mg. HR, SAP and DAP either showed no variations or marginal insignificant shifts. STI decreased evidencing a dose-related positive inotropic effect like digitalis, but shorter than digitalis. SB 7505 also showed diuretic action with all three doses investigated. The positive inotropic effect and diuretic activity point to the possible usefulness of SB 7505 in treating some heart and kidney diseases.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001806:Blood Urea Nitrogen; D003846:Deoxyepinephrine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D004298:Dopamine / Q000031:analogs & derivatives*; D006321:Heart / Q000187:drug effects*; D006400:Hematocrit; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects*; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood; D013599:Systole / Q000187:drug effects*; D013997:Time Factors
D001786:Blood Glucose; C023487:ibopamine; D012964:Sodium; D003846:Deoxyepinephrine; D011188:Potassium; D004298:Dopamine