The induction of sister-chromatid exchanges in Chinese hamster ovary cells by some epoxides and phenolic derivatives of benzo[a]pyrene.
The induction of sister-chromatid exchanges in Chinese hamster ovary cells by in vivo treatment with a number of epoxy and phenolic derivatives of the carcinogenic polycyclic hydrocarbon, benzo[a]pyrene, has been investigated. Of the 3 vicinal diol-epoxides tested the anti-isomer of the bay-region 7,8-dihydrodiol-9,10-epoxide was the most active since, when tested at a 10-fold lower concentration, it induced the same number of sister-chromatid exchanges as the corresponding syn-isomer. The anti-isomer of the non-bay-region 9,10-dihydrodiol-7,8-epoxide was much less active than either of the bay-region diolepoxides and its activity was comparable with those of the 2 simple oxides tested, the K-region 4,5- and the non-K-region 7,8-oxides, of benzo[a]pyrene. The 2 phenols tested, 3- and 4-hydroxybenzo[a]pyrene, were only slightly active in inducing sister-chromatid exchanges.
D000818:Animals; D001580:Benzopyrenes / Q000494:pharmacology*; D002460:Cell Line; D002842:Chromatids / Q000187:drug effects; D006224:Cricetinae; D003412:Cricetulus; D003434:Crossing Over, Genetic; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004852:Epoxy Compounds / Q000494:pharmacology*; D004988:Ethers, Cyclic / Q000494:pharmacology*; D005260:Female; D009153:Mutagens; D010053:Ovary; D010636:Phenols / Q000494:pharmacology; D012854:Sister Chromatid Exchange
D001580:Benzopyrenes; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D009153:Mutagens; D010636:Phenols