[Gentamycin kinetics when administered into the eyes via soft contact lenses].
Pharmacokinetics of gentamicin administered into the eye by means of instillation or hydrophilic contact lenses was studied comparatively. The results of the study showed that gentamicin levels in the humor of the eye anterior chamber after the antibiotic administration with soft contact lenses were higher at all periods than those after instillation. Higher retention time of gentamicin therapeutic doses in the humor of the eye anterior chamber after the antibiotic administration by means of soft contact lenses is also an advantage of this administration route.
D000818:Animals; D003263:Contact Lenses, Hydrophilic; D005123:Eye / Q000187:drug effects*; D005839:Gentamicins / Q000008:administration & dosage / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D009883:Ophthalmic Solutions; D011817:Rabbits
D005839:Gentamicins; D009883:Ophthalmic Solutions
Kinetika gentamitsina pri vvedenii ego v glaz s pomoshch'iu miagkikh kontaktnykh linz.