Specific calcium-dependent release of endogenous glutamate from rat striatum is reduced by destruction of the cortico-striatal tract.
Rat neostriatal slices exhibited a Ca2+-dependent release of endogenous glutamate when depolarized by elevated K+. This evoked release was reduced by 30% in tissue from animals subjected to fronto-parietal lesions 3 weeks previously. These results support the proposal that glutamate is the transmitter of the cortico-striatal pathway.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000502:physiology*; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D005971:Glutamates / Q000378:metabolism*; D009434:Neural Pathways / Q000502:physiology; D051381:Rats
D005971:Glutamates; D002118:Calcium