Ontogeny of behavioral sensitivity to glycine in the chick embryo.
Strychnine (STR), glycine (GLY), and gamma-aminobutyric acid (GABA) were injected intravenously into 6- and 7-day chick embryos and subsequent effects upon spontaneous motility were observed. In 7-day embryos STR alone increased motility and when injected simultaneously with GLY antagonized the GLY-induced motility decrements; STR did not antagonize GABA-induced motility decrements. In 6-day embryos STR injected alone had no effect on motility, but did antagonize motility decrements induced by the simultaneous injection of GLY; again STR did not antagonize GABA-induced motility decrements.
D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002642:Chick Embryo; D005998:Glycine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D013331:Strychnine / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D005680:gamma-Aminobutyric Acid; D013331:Strychnine; D005998:Glycine