[Levomycetin dispersity and its effect on the intensity of absorption].
The dispersion composition of levomycetin (chloramphenicol) was studied comparatively with various methods. The optimal results were obtained with the use of microscopic assay. The samples used for the comparison were sufficiently differentiated by the specific surface of the powder, its dry and bulk weights determined with less labour-consuming methods. Differenes in the antibiotic dissolution rate dependent on the dispersity level were shown: the dissolution rate of fine crystalline powder was much higher than that of macrocrystalline powder. Correlation between the rate of the antibiotic transfer into solution in vitro and blood absorption in rabbits was shown with the use of the powders of various dispersity.
D000042:Absorption; D000818:Animals; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D002701:Chloramphenicol / Q000097:blood*; D066298:In Vitro Techniques; D010316:Particle Size; D011208:Powders; D011817:Rabbits; D012995:Solubility; D013997:Time Factors
D011208:Powders; D002701:Chloramphenicol
Stepen' dispersnosti levomitsetina i ee vliianie na intensivnost' vsasyvaniia.