Antibodies in hemodialysis patients against hapten-protein and hapten-erythrocytes.
Serum samples obtained from hemodialysis patients with immediate-type hypersensitivity reactions and hemodialysis patients with no reactions were analyzed for antibody activity against hapten-protein complexes prepared from PA and MDI. These chemicals, used in preparation of plastics, have been shown to be associated with immunologically mediated disease in other studies. IgE and IgG antibodies against P-HSA and MDI-HSA were detected in several sera, but symptomatic patients could not be differentiated from asymptomatic patients by antibody levels. Antibodies capable of agglutinating or hemolyzing P-E were also detected in some sera from hemodialysis patients. These studies demonstrate that although no clinical disease has yet been correlated with these antibodies, sufficient exposure of hemodialysis patients to protein-reactive chemicals occurs to elicit an immunologic response against hapten-protein or hapten-cells. Such antibodies may have immunopathogenetic significance in subjects systemically exposed to fluids which have been in contact with plastics.
D000418:Albumins / Q000276:immunology; D000906:Antibodies / Q000032:analysis*; D004912:Erythrocytes / Q000276:immunology; D006241:Haptens / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D010796:Phthalic Anhydrides / Q000276:immunology; D011863:Radioimmunoassay; D006435:Renal Dialysis
D000418:Albumins; D000906:Antibodies; D006241:Haptens; D007074:Immunoglobulin G; D010796:Phthalic Anhydrides; D007073:Immunoglobulin E