The effect of metal salts on the distribution of iron-59 in rats: Manganese (II), nickel (II) and tin (II).
The disappearance and reappearance of iron-59 in plasma and blood at various time intervals has been studied in control, manganese, nickel and tin administered and anaemic rats after a single intravenous injection of an aqueous solution of radioactive iron (III) citrate. Significant difference was observed in the rate of reappearance of iron-59 in the circulation between control and manganese treated animals. The disappearance of iron-59 from the plasma of control and treated animals however did not show any appreciable difference. A significant increase in the radio-iron content was observed in bone marrow, liver and kidney of treated animals as compared to control group forty eight hours after Fe-59.
D000740:Anemia / Q000097:blood; D000818:Animals; D005260:Female; D007275:Injections, Intravenous; D007501:Iron / Q000008:administration & dosage / Q000097:blood*; D008345:Manganese / Q000494:pharmacology*; D009532:Nickel / Q000494:pharmacology*; D051381:Rats; D014001:Tin / Q000494:pharmacology*
D008345:Manganese; D014001:Tin; D009532:Nickel; D007501:Iron