Plaminogen is synthesized by primary cultures of rat hepatocytes.
The accumulation of rat plasminogen in the medium of primary monolayer cultures of adult parenchymal hepatocytes was detected with a quantitative immunological assay. These primary cultures synthetisized and secreted both circulating isozymic forms of plasminogen at rates sufficient to account for the majority of the in vivo plasminogen turnover.
D000818:Animals; D002478:Cells, Cultured; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D008099:Liver / Q000378:metabolism*; D008297:Male; D010958:Plasminogen / Q000096:biosynthesis*; D051381:Rats
D010958:Plasminogen