[Age peculiarities of the citrate-pyruvate system functional in rat liver].
The ATP-citrate-lyase activity (EC 4.1.3.8) is established to increase by the age of three months and then to lower gradually with age. An increase in the NAD-dependent malate dehydrogenase (EC 1.1.1.37) activity by the period of the puberty is followed by its decrease in the period of ageing. The activity of decarboxylating NADP-malate dehydrogenase (EC 1.1.1.40) is sharply decreased already by the age of three months and lowers still more with ageing. A conclusion is drawn that with the organism ageing the supply of lipogenesis with reduced NADP and acetyl-CoA in the rat liver tissue is weakened.
D001275:ATP Citrate (pro-S)-Lyase / Q000378:metabolism*; D000375:Aging; D000818:Animals; D002951:Citrates / Q000378:metabolism*; D008099:Liver / Q000201:enzymology* / Q000254:growth & development; D008291:Malate Dehydrogenase / Q000378:metabolism*; D011773:Pyruvates / Q000378:metabolism*; D051381:Rats
D002951:Citrates; D011773:Pyruvates; D008291:Malate Dehydrogenase; D001275:ATP Citrate (pro-S)-Lyase
Vozrastnye osobennosti funktsionirovaniia tsitrat-piruvatnoi sistemy v pecheni krys.