Sar1-Ile8-angiotensin II decreases urinary PGE2 and PGF2alpha excretion in rabbits on dietary sodium restriction.
Urinary PGE2 and PFG 2 alpha excretion (UPGV) were determined prior, during and after 48 h treatment with angiotensin-II-blocker, Sar1-Ile8-angiotensin II (200 microgram/kg/3 h), in rabbits maintained on chronic low (LS) or high (HS) salt diets. UPGE2V and F2 alpha were significantly (P < 0.001) higher in LS than in HS. Sar1-Ile-8-angiotensin II decreased the elevated UPGE2 V and UPGF2 alpha V in LS from 2.60 +/- 0.084 microgram/24 h to 1.13 +/- 0.21 microgram/24 h and from 6.63 +/- 0.61 to 3.77 +/- 0.86 microgram/24 h respectively. In animals with HS intake, angiotensin II blockade failed to effect urinary prostaglandin excretion.
D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000494:pharmacology*; D000804:Angiotensin II / Q000031:analogs & derivatives*; D000818:Animals; D004039:Diet, Sodium-Restricted; D007668:Kidney / Q000378:metabolism; D008297:Male; D011453:Prostaglandins / Q000378:metabolism; D011458:Prostaglandins E / Q000652:urine*; D011460:Prostaglandins F / Q000652:urine*; D011817:Rabbits
D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; D000804:Angiotensin II; D015059:1-Sarcosine-8-Isoleucine Angiotensin II