Differentiation of mouse neuroblastoma cells under increased oxygen tension.
After exposure to increased oxygen tension for 3 days, cultured mouse neuroblastoma cells were found to undergo morphological differentiation and to significantly increase their ecto-acetylcholinesterase activity. Differentiation could not be blocked by KCN or lipid-soluble antioxidants, indicating that neither an increased respiration, nor an increased oxidation of membrane lipids was responsible for the effect.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D002454:Cell Differentiation; D002999:Clone Cells / Q000187:drug effects / Q000201:enzymology; D051379:Mice; D009374:Neoplasms, Experimental / Q000201:enzymology; D009447:Neuroblastoma / Q000201:enzymology*; D010100:Oxygen; D010313:Partial Pressure
D000975:Antioxidants; D000110:Acetylcholinesterase; D010100:Oxygen