[Effect of body regulatory mechanisms on the catalytic activity of exogenous enzymes].
An increase in the activity of RNAase in the organs and tissues of mice after administration of exogenous RNAases (pancreatic and actinomycetous) was studied. It was found that the increase in the RNAase activity was higher after administration of the actinomycetous enzyme. This was due to the difference in the sensitivity of the exogenous enzymes to the inhibitor of the mouse RNAase. The pancreatic RNA ase was much more senstive to the inhibitor. The capacity of the mouse blood serum to inhibit trypsin and chymotrypsin of the cattle pancreas, protease of Asp. terricola (terrilytin) and papain was also studied comparatively. It was shown that the pancreatic proteases were more senstive to the serum inhibitor. It is suggested that enzymes less sensitive to the effect of the host regulatory mechanisms (targets), i.e. enzymes of lower organisms, such as microbes and plants should be used in the enzyme therapy for increasing the catalytic activity of the host.
D000818:Animals; D002384:Catalysis; D004353:Drug Evaluation, Preclinical; D004789:Enzyme Activation / Q000187:drug effects; D057487:Enzyme Therapy; D006706:Homeostasis / Q000187:drug effects*; D008297:Male; D051379:Mice; D010179:Pancreas / Q000201:enzymology; D012260:Ribonucleases / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000627:therapeutic use; D013302:Streptomyces / Q000201:enzymology
D012260:Ribonucleases
Vliianie reguliatornykh mekhanizmov organizma na kataliticheskuiu aktivnost' ékzogennykh fermentov.