Central cardiovascular actions of d-tubocurarine and inhibition of the hypotensive effect of clonidine.
Intracisternal (i. cist.) administration of d-tubocurarine (0.025-0. 100 mg. kg-1) in alpha-chloralose-anaesthetized dogs caused a dose-related increase in blood pressure associated with seizures. When injected in dogs pretreated with guanethidine (15 mg. i.v.), d-tubocurarine elicited the same effect while bilateral adrenalectomy abolished the pressor response. The hypotensive effect of clonidine (0.003 mg. kg-1 i. cist.) was reversed when clonidine was given after the alkaloid. These results suggest possbile interactions of the drugs at central GABA-ergic, glycinergic or cholinergic synapses.
D000315:Adrenalectomy; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001921:Brain / Q000187:drug effects*; D002946:Cisterna Magna; D003000:Clonidine / Q000037:antagonists & inhibitors*; D004285:Dogs; D005260:Female; D006145:Guanethidine / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D007267:Injections; D008297:Male; D014403:Tubocurarine / Q000008:administration & dosage / Q000494:pharmacology*
D003000:Clonidine; D014403:Tubocurarine; D006145:Guanethidine