Application of perfuluorochemicals in human beings-- a morphological report of a human autopsy case with some experimental studies using rabbit.
The first autopsy case of a patient treated with Perfluorochemicals (PFC, fluorocarbon) for hemolytic anemia, occurring after an operation for dissecting aneurysm, is reported. The results of preliminary experiments on the effects of histopathological manifestation of tissue with the administration of Perfluorochemicals in rabbit are also described. Both in human and experimental materials, the reticuloendothelial organs, blood monocytes and macrophages including histiocytes were markedly blocked in their phagocytic activities in every portion of the organs examined, and transformed themselves into ballooning foamy cells upon administration of PFC. Morphologically, the excretion of this chemical from either the lung or the urinary system can not be certified. The particles compatible to Perfluorochemicals are still found in the cytoplasm of cells in various organs, a full four months after the administration of Perfluorochemicals in the experiments. It is evident that further studies are necessary, regarding the use of Perfluorochemical in human beings.
D000743:Anemia, Hemolytic / Q000188:drug therapy; D000818:Animals; D001853:Bone Marrow / Q000648:ultrastructure; D004731:Endotoxins / Q000633:toxicity; D005466:Fluorocarbons / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D005487:Foam Cells / Q000648:ultrastructure; D006801:Humans; D007249:Inflammation / Q000473:pathology; D007668:Kidney / Q000648:ultrastructure; D008099:Liver / Q000648:ultrastructure; D008168:Lung / Q000648:ultrastructure; D008198:Lymph Nodes / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D010587:Phagocytosis; D011817:Rabbits; D012867:Skin / Q000473:pathology; D013154:Spleen / Q000648:ultrastructure
D004731:Endotoxins; D005466:Fluorocarbons