Nifedipine for digitalis-induced arrhythmias.
The calcium antagonist, nifedipine (Adalat; Bayer), has previously been thought by most workers to lack cardiac-anti-arrhythmic properties, thus differing from verapamil. We have found that nifedipine was successful in converting cardiac glycoside (K-strophanthoside)-induced ventricular tachycardia to sinus rhythm in 4 of 5 anaesthetized dogs when given intravenously. In this respect, therefore, nifedipine is similar to verapamil. Further work is advocated before applying these results to the clinical situation in man.
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D004285:Dogs; D009543:Nifedipine / Q000627:therapeutic use*; D010672:Phenytoin / Q000627:therapeutic use; D011725:Pyridines / Q000627:therapeutic use*; D013328:Strophanthins / Q000494:pharmacology; D014700:Verapamil / Q000627:therapeutic use
D011725:Pyridines; D013328:Strophanthins; D010672:Phenytoin; D014700:Verapamil; D009543:Nifedipine