Radioimmunodetection of gastrointestinal neoplasms with antibodies to carcinoembryonic antigen.
Primary and secondary gastrointestinal tumors have been identified using sheep immunoglobulin G antibody to carcinoembryonic antigen radiolabeled with 131I. 99mTc-pertechnetate and 99mTc-human serum albumin were used to identify tissue spaces and blood pool and to facilitate external substraction imaging. In 13 patients with tumors, 4 of 5 primary sites and 8 of 11 secondary sites were successfully demonstrated. Two patients with benign disease had negative scans. Comparison with conventional methods of scanning showed good correlation.
D000912:Antibodies, Neoplasm / Q000008:administration & dosage*; D002272:Carcinoembryonic Antigen / Q000032:analysis / Q000276:immunology*; D005770:Gastrointestinal Neoplasms / Q000000981:diagnostic imaging* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage; D007457:Iodine Radioisotopes; D011877:Radionuclide Imaging / Q000379:methods*; D013667:Technetium; D013997:Time Factors
D000912:Antibodies, Neoplasm; D002272:Carcinoembryonic Antigen; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D013667:Technetium