[Determination of pituitary hormones in cerebrospinal fluid in normal subjects and in hypothalamo-pituitary diseases. Secreting or non-secreting pituitary adenoma, empty sella syndrome, hypothalamic syndromes].
Cerebrospinal fluid (CSF) and serum concentrations of TSH, ACTH, FSH, LH, GH and PRL were measured simultaneously in 34 subjects divided into 3 groups: I--12 normal subjects (6 males and 6 females); II--12 prolactin adenomas (3 males and 9 females); III--5 empty sella syndromes; 3 hypothalamic disorders; 1 chromophobe adenoma; 1 pituitary dwarfism. It is concluded that:--pituitary hormones are the normal constituents of CSF but the level can be undetectable and in any case lower than the serum level; --there is a positive correlation between serum and CSF concentration of PRL when serum PRL is higher than 20 ng/ml, indicating that the CSF level is influenced by serum level; --in prolactin adenomas only prolactin is elevated in the CSF; --there is no correlation between the high level of CSF-PRL and a suprasellar extension of the adenoma.
D000236:Adenoma / Q000097:blood / Q000134:cerebrospinal fluid* / Q000378:metabolism; D001927:Brain Diseases / Q000134:cerebrospinal fluid; D004652:Empty Sella Syndrome / Q000097:blood / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D007031:Hypothalamus; D008297:Male; D010900:Pituitary Diseases / Q000378:metabolism; D010908:Pituitary Hormones, Anterior / Q000097:blood / Q000134:cerebrospinal fluid*; D010911:Pituitary Neoplasms / Q000097:blood / Q000134:cerebrospinal fluid* / Q000378:metabolism; D011388:Prolactin / Q000378:metabolism
D010908:Pituitary Hormones, Anterior; D011388:Prolactin
Le dosage des stimulines hypophysaires dans le liquide céphalo-rachidien chez le sujet normal et en pathologie hypothalamo-hypophysaire. Adénome hypophysaire sécrétant ou non sécrétant, selle turcique vide, syndromes hypothalamiques.