Liposomes in immunology: multilamellar phosphatidylcholine liposomes as a simple, biodegradable and harmless adjuvant without any immunogenic activity of its own.
Multilamellar phosphatidylcholine liposomes were coated with the antigens human serum  albumin (HSA) or bovine gamma globulin (BGG) simply by suspending the liposomes in a solution of the antigens. Antigen coated  phosphatidylcholine liposomes showed nearly the same adjuvant activity after intravenous injection as liposomes of a more complex phospholipid composition. Since phosphatidylcholine liposomes are biodegradable, harmless, easily obtainable, have no immunogenic activity of their own and may be administered intravenously, they seem to be a promising immunoadjuvant.
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000941:Antigens; D001673:Biodegradation, Environmental; D002784:Cholesterol / Q000494:pharmacology; D006801:Humans; D008081:Liposomes / Q000276:immunology*; D008297:Male; D010712:Phosphatidic Acids / Q000494:pharmacology; D010713:Phosphatidylcholines / Q000494:pharmacology; D011817:Rabbits; D012709:Serum Albumin / Q000276:immunology; D013109:Sphingomyelins / Q000494:pharmacology
D000276:Adjuvants, Immunologic; D000941:Antigens; D008081:Liposomes; D010712:Phosphatidic Acids; D010713:Phosphatidylcholines; D012709:Serum Albumin; D013109:Sphingomyelins; D002784:Cholesterol