Factor VII inhibitor.
Factor VII inhibitor activity was identified in a 66 year old man with probable bronchogenic carcinoma. Initial studies indicated a normal partial thromboplastin time (PTT) and a prothrombin time (PT) prolongation which increased with incubation. PT correction failed to occur with 50 per cent normal plasma in vitro and 2 U of fresh frozen plasma in vivo, indicating inhibitor activity. Specific factor assay levels fell within normal limits except for a factor VII level of 30 per cent. Subsequent evaluation with antiglobulin studies suggested an inhibitor of immunoglobulin G [IgG] origin.
D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D002283:Carcinoma, Bronchogenic / Q000097:blood*; D005167:Factor VII / Q000037:antagonists & inhibitors* / Q000276:immunology; D006801:Humans; D007074:Immunoglobulin G; D008175:Lung Neoplasms / Q000097:blood*; D008297:Male; D010314:Partial Thromboplastin Time; D011517:Prothrombin Time
D001323:Autoantibodies; D007074:Immunoglobulin G; D005167:Factor VII