Drug trials: treatment of urinary tract infection with multiple-dose intramuscular administration of cephamandole.
Therapy with cephamandole (1.0 g, every eight hours) for five days was effective in eliminating cephamandole-sensitive microorganisms from the urinary tract. A 75% cure rate was achieved in a group of 20 patients, 45% of whom had abnormalities of the urinary tract. Local pain (despite addition of lignocaine) was sufficiently prolonged and severe to make multiple-dose intramuscular administration unacceptable. No other toxic effects were encountered.
D000892:Anti-Infective Agents, Urinary / Q000008:administration & dosage* / Q000378:metabolism; D002435:Cefamandole / Q000008:administration & dosage* / Q000378:metabolism; D002511:Cephalosporins / Q000008:administration & dosage*; D004756:Enterobacteriaceae Infections / Q000188:drug therapy; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000209:etiology; D013203:Staphylococcal Infections / Q000188:drug therapy; D014552:Urinary Tract Infections / Q000188:drug therapy*
D000892:Anti-Infective Agents, Urinary; D002511:Cephalosporins; D002435:Cefamandole