title: Induction of hepatocellular carcinoma in rat liver by initial treatment with benzo(a)pyrene after partial hepatectomy and promotion by phenobarbital.
abstract: The hepatocarcinogenicity of benzo(a)pyrene(BP) in the rat was examined. Rats were treaated with BP after partial hepatectomy and then kept on a diet containing phenobarbital (PB) as a promoter. Tumors including a hepatocellular carcinoma developed in the rat liver by week 52.
mesh_terms: D000818:Animals; D001580:Benzopyrenes / Q000633:toxicity*; D006498:Hepatectomy; D008099:Liver / Q000473:pathology; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000473:pathology; D008297:Male; D010634:Phenobarbital / Q000494:pharmacology*; D051381:Rats
chemical_list: D001580:Benzopyrenes; D010634:Phenobarbital