Prostaglandins and gastric ulcer.
Interest in the prostaglandins as possible gastric-mucosal cytoprotective agents was first aroused by the oberved antagonism between these compounds and ulcerogenic anti-inflammatory drugs. It has now been shown that several PGs can depress gastric acid secretion and reduce HCl-induced lesions in experimental animals. The clinical implications appear to be well worth exploration.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology; D005750:Gastric Juice / Q000187:drug effects; D005753:Gastric Mucosa / Q000187:drug effects; D011453:Prostaglandins / Q000502:physiology*; D011459:Prostaglandins E, Synthetic / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D013276:Stomach Ulcer / Q000503:physiopathology* / Q000517:prevention & control
D000893:Anti-Inflammatory Agents; D011453:Prostaglandins; D011459:Prostaglandins E, Synthetic