title: Alterations in glucocorticoid receptor conformation by molybdate.
abstract: Glucocorticoid receptor activities in cytosol from lactating rat mammary glands were greatly stabilized by molybdate against inactivation during incubation at 25 degrees C. The sedimentation coefficient was 9-10S in the presence of 10 mM Na2MoO4, but 6-7S in the absence of the ion. These data strongly suggest that alterations in receptor conformation induced by direct interaction with molybdate are involved in the stabilization process.
mesh_terms: D000818:Animals; D003600:Cytosol / Q000378:metabolism; D003907:Dexamethasone / Q000378:metabolism; D004355:Drug Stability; D005260:Female; D007700:Kinetics; D007774:Lactation; D008321:Mammary Glands, Animal / Q000378:metabolism*; D008982:Molybdenum / Q000494:pharmacology*; D011247:Pregnancy; D011487:Protein Conformation; D051381:Rats; D011965:Receptors, Glucocorticoid / Q000187:drug effects / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*
chemical_list: D011965:Receptors, Glucocorticoid; D011987:Receptors, Steroid; D003907:Dexamethasone; D008982:Molybdenum; C024687:sodium molybdate(VI)