Binding and factor XIIIa-mediated cross-linking of a 27-kilodalton fragment of fibronectin to Staphylococcus aureus.
A 27-kilodalton tryptic fragment, derived from the amino terminus of the 200-kilodalton fibronectin subunit, inhibited binding of intact fibronectin to Staphylococcus aureus and could be cross-linked to Staphylococcus aureus by blood coagulation Factor XIIIa. Interactions of fibronectin with Staphylococcus aureus via this fragment may be important for bacterial opsonization and attachment.
D000595:Amino Acid Sequence; D005176:Factor XIII / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D008970:Molecular Weight; D009895:Opsonin Proteins; D010446:Peptide Fragments; D011485:Protein Binding; D013211:Staphylococcus aureus / Q000276:immunology / Q000378:metabolism*; D014357:Trypsin / Q000378:metabolism
D005353:Fibronectins; D009895:Opsonin Proteins; D010446:Peptide Fragments; D005176:Factor XIII; D014357:Trypsin