Effects of Pentoxifylline on flap survival.
Based on our experimental studies in rats and our clinical experiences, Pentoxifylline appears to have a potential application in the treatment of a skin flap in danger of necrosis. We believe that improving the deformability of red blood cells by increasing ATP content is an important factor in flap survival.
D000227:Adenine Nucleotides / Q000097:blood; D000328:Adult; D000818:Animals; D001809:Blood Viscosity / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006085:Graft Survival / Q000187:drug effects*; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008875:Middle Aged; D010431:Pentoxifylline / Q000008:administration & dosage / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D051381:Rats; D012867:Skin / Q000098:blood supply; D013524:Surgical Flaps; D013805:Theobromine / Q000031:analogs & derivatives*
D000227:Adenine Nucleotides; D013805:Theobromine; D010431:Pentoxifylline