The influence of codon context on genetic code translation.
A class of mutations that increase the deficiency of a suppressor tRNA in translating a particular amber codon has been characterized. The increased efficiency is due to a mutation resulting in a change in the mRNA that affects the nucleotide adjacent to the 3' side of the UAG triplet. Thus the interaction of tRNA with mRNA is influenced by mRNA sequences outside the triplet codon.
D001483:Base Sequence; D003062:Codon; D004269:DNA, Bacterial / Q000235:genetics; D005815:Genetic Code; D006639:Histidine / Q000235:genetics; D009154:Mutation; D009876:Operon; D014176:Protein Biosynthesis; D011560:Pseudouridine / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics*; D012343:RNA, Transfer / Q000235:genetics*; D013489:Suppression, Genetic
D003062:Codon; D004269:DNA, Bacterial; D012333:RNA, Messenger; D011560:Pseudouridine; D006639:Histidine; D012343:RNA, Transfer