title: [Dynamics of incorporation of 3H-actinomycin D into synchronized Chinese hamster cells].
abstract: Dynamics of 3H-actinomycin D (3H-AMD) incorporation has been studied in the Chinese hamster synchronized cell culture (line 237) during different cell cycle phases. Intensive isotope inclusions were seen in cells during interphase: in the beginning of G1 period, in the early S period, and in the late S period, during the cell passage to G2 stage. The authors suggest that the binding of 3H-AMD by cells may be due not only to conformational changes of DNA structure, but also due to the variation in cell membrane penetration throughout the mitotic cycle.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003609:Dactinomycin / Q000378:metabolism*; D066298:In Vitro Techniques; D007399:Interphase; D008938:Mitosis; D014316:Tritium
chemical_list: D014316:Tritium; D003609:Dactinomycin
vernacular_title: Dinamika vkliucheniia 3H-aktinomitsina D v sinkhronizirovannye kletki kitaĭskogo khomiachka.