The influence of protein binding upon tissue fluid levels of six beta-lactam antibiotics.
The effect of protein binding upon the penetration of six-beta-lactam (three penicillins and three cephalosporins) antibiotics into tissue fluid was studied in humans. A cantharides blister technique was used. It was found that there was a linear relationship between the percentage of protein binding and the penetration into the blister fluid of the antibiotic as measured by the area under the curve of the protein-free fraction. This finding is further evidence that protein binding may have important influence upon the likely efficacy of an antimicrobial agent.
D000328:Adult; D000658:Amoxicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001390:Azlocillin / Q000031:analogs & derivatives*; D001768:Blister / Q000503:physiopathology; D002440:Cefoxitin / Q000494:pharmacology; D002441:Cefsulodin; D002444:Cefuroxime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology; D005436:Floxacillin / Q000494:pharmacology; D006801:Humans; D048289:Imidazolidines; D008297:Male; D010406:Penicillins / Q000494:pharmacology; D011485:Protein Binding; D047090:beta-Lactams / Q000494:pharmacology*
D000900:Anti-Bacterial Agents; D002511:Cephalosporins; D048289:Imidazolidines; D010406:Penicillins; D047090:beta-Lactams; D005436:Floxacillin; D002440:Cefoxitin; D000658:Amoxicillin; D001390:Azlocillin; C017976:furazlocillin; D002444:Cefuroxime; D002441:Cefsulodin