title: [Intracranial saccular aneurysms: experimental evaluation of intravascular therapeutic procedures].
abstract: Studies were performed on adult mongrel dogs to evaluate the possibility of occluding saccular aneurysms with an intravascular injection of the tissue adhesive Bucrylat (isobutyl-2-cyanoacrylate). Fourteen surgically constructed carotid aneurysms were occluded by the injection of Bucrylat through a fluoroscopically positioned intra-arterial catheter. Angiography performed immediately before and after injection and up to 1 month following treatment revealed progressive and persistent occlusion of the aneurysms. The specimens examined histologically 1 month after the injection showed an endothelialized fibrous tissue bridge crossing the neck of the aneurysm what appear to indicate a permanent occlusion of the structures treated. A similar approach to treat intracranial aneurysms will depend on advances in the field of selective intracranial catheterization that will permit safe and accurate catheterization of the aneurysm sac.
mesh_terms: D000818:Animals; D002015:Bucrylate / Q000008:administration & dosage* / Q000494:pharmacology; D002339:Carotid Arteries; D002404:Catheterization; D003487:Cyanoacrylates / Q000008:administration & dosage*; D004285:Dogs; D004621:Embolization, Therapeutic / Q000379:methods*; D007269:Injections, Intra-Arterial; D002532:Intracranial Aneurysm / Q000000981:diagnostic imaging / Q000473:pathology / Q000628:therapy*; D011859:Radiography
chemical_list: D003487:Cyanoacrylates; D002015:Bucrylate
vernacular_title: Aneurismas saculares intracranianos: avaliação experimental de procedimento terapêutico por via intravascular.