title: Hyperformaldehydism: a unifying hypothesis for the major biochemical theories of schizophrenia.
abstract: A biochemical hypothesis concerning the etiology of schizophrenia is presented. This hypothesis postulates the presence of a genetically determined lesion in the disposition of one-carbon units leading to elevated levels of formaldehyde, i.e hyperformaldehydism. The relationships between this hypothesis and the existing major biochemical hypotheses of schizophrenia regarding dopamine and transmethylation are discussed.
mesh_terms: D002243:Carbolines / Q000097:blood; D004298:Dopamine / Q000378:metabolism; D005557:Formaldehyde / Q000097:blood*; D005574:Formate-Tetrahydrofolate Ligase / Q000097:blood; D006801:Humans; D007546:Isoquinolines / Q000097:blood; D008715:Methionine / Q000097:blood; D008995:Monoamine Oxidase / Q000097:blood; D012559:Schizophrenia / Q000201:enzymology*
chemical_list: D002243:Carbolines; D007546:Isoquinolines; D005557:Formaldehyde; D008715:Methionine; D008995:Monoamine Oxidase; D005574:Formate-Tetrahydrofolate Ligase; D004298:Dopamine