Toxicological studies of liver cells by microspectrofluorometry.
The kinetics of xenobiotic biotransformation was measured in single, isolated, perifused liver cells with microspectrofluorometry using highly sensitive photodetection systems. A program of further applications to biochemical toxicological problems is presented.
D000818:Animals; D001711:Biotransformation; D066298:In Vitro Techniques; D007700:Kinetics; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008832:Microchemistry; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010078:Oxazines / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D010777:Photochemistry; D051381:Rats; D013050:Spectrometry, Fluorescence; D014116:Toxicology
D010078:Oxazines; D004364:Pharmaceutical Preparations; D009243:NAD; D009249:NADP; C014180:resorufin; D006899:Mixed Function Oxygenases