Reversal of non-depolarizing block by neostigmine.
Paralysis was maintained in the sheep for 30 or 90 minutes by computer-controlled injection of gallamine, pancuronium, alcuronium or d-tubocurarine, using the integrated electromyogram as a measure of neuromuscular transmission. Neostigmine was given and the recovery time measured. In all trials the recovery rise time was no longer than two minutes, but varied between one and two minutes.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D009388:Neostigmine / Q000008:administration & dosage*; D009466:Neuromuscular Blocking Agents / Q000037:antagonists & inhibitors*; D010243:Paralysis / Q000139:chemically induced*; D012756:Sheep
D009466:Neuromuscular Blocking Agents; D009388:Neostigmine