[Effect of a monoamine oxidase inhibitor on the level of seizure readiness and functional asymmetry of the brain].
The state of seizures readiness in epileptic rats of Krushinsky--Molodkina line is characterised by interhemispheric synchroneity, revealed with electrophysiological methods parallely with the study of the catecholamine content in the brain tissue. On the contrary in animals insensitive to epileptogenic stimulus, considerable manifestations of the functional interhemispheric asymmetry were recorded. The monoaminoxidase inhibitor iprazide increasing the adrenaline and noradrenaline content in the brain and causing their uneven distribution between the hemispheres, leads to a sharp decline in the level of seizures readiness, which is accompanied by the appearance of bioelectrical and catecholamine asymmetry comparable with that in the animals resistent to the epileptogenic stimulus.
D000818:Animals; D001921:Brain / Q000503:physiopathology*; D001923:Brain Chemistry; D003337:Corpus Callosum / Q000503:physiopathology; D004292:Dominance, Cerebral / Q000502:physiology; D004837:Epinephrine / Q000032:analysis; D007031:Hypothalamus / Q000503:physiopathology; D007490:Iproniazid / Q000627:therapeutic use*; D009044:Motor Cortex / Q000503:physiopathology; D009638:Norepinephrine / Q000032:analysis; D051381:Rats; D011919:Rats, Inbred Strains; D012640:Seizures / Q000378:metabolism / Q000503:physiopathology / Q000517:prevention & control*; D013003:Somatosensory Cortex / Q000503:physiopathology; D013788:Thalamus / Q000503:physiopathology
D007490:Iproniazid; D009638:Norepinephrine; D004837:Epinephrine
Vliianie ingibitora monoaminoksidazy na uroven' sudorozhnoĭ gotovnosti i funktsional'nuiu asimmetriiu mozga.