Quantitation by gas chromatography-chemical ionization-mass spectrometry of phenylalanine mustard in plasma of patients.
An unambiguous and sensitive method based on gas chromatography-chemical ionization-mass spectrometry has been developed to quantitate L-phenylalanine mustard and has been applied to measure levels in plasma of five patients receiving 0.15 to 0.25 mg/kg (10 to 17 mg) of the drug p.o. Peak plasma levels of 50 to 190 ng/ml were found to occur between 0.7 and 2.3 hr after ingestion. The time for the plasma level to fall to one-half of the peak value varied from 0.6 to 3 hr, and very low levels (less than 2 ng/ml) were present by 24 hr.
D000230:Adenocarcinoma / Q000097:blood / Q000188:drug therapy; D000368:Aged; D003110:Colonic Neoplasms / Q000097:blood / Q000188:drug therapy; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D008558:Melphalan / Q000008:administration & dosage / Q000097:blood*; D008654:Mesothelioma / Q000097:blood / Q000188:drug therapy; D009101:Multiple Myeloma / Q000097:blood / Q000188:drug therapy; D010051:Ovarian Neoplasms / Q000097:blood / Q000188:drug therapy; D013997:Time Factors
D008558:Melphalan