Biological effects of 15-hydroperoxythromboxane A2 on platelets and aorta.
The conversion of PGG2 to 15-hydroperoxythromboxane A2 by purified thromboxane synthase from human platelets was recently reported (Hammarström, S. (1980) J. Biol. Chem.255, 518). The hydroperoxythromboxane is approximately 25 times more potent than PGG2 in causing aggregation of human platelet rich plasma and 30 times more potent than PGG2 as an inducer of contractions of rabbit aorta.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010974:Platelet Aggregation / Q000187:drug effects*; D011462:Prostaglandins G / Q000494:pharmacology; D011463:Prostaglandins H / Q000494:pharmacology; D011817:Rabbits; D013928:Thromboxane A2 / Q000031:analogs & derivatives / Q000494:pharmacology*; D013931:Thromboxanes / Q000494:pharmacology*
D011462:Prostaglandins G; D011463:Prostaglandins H; D013931:Thromboxanes; D013928:Thromboxane A2; C024136:15-hydroperoxythromboxane A2