Effects of butyrophenone and phenothiazine derivatives on the caudate spindle.
Effects of butyrophenone and phenothiazine derivatives on the caudate spindle were examined in gallamine-immobilized cats. Butyrophenone derivatives (haloperidol, trifluperidol and methylperidol; 0.5-8.0 mg/kg i.v.) inhibited the caudate spindle activity in a dose-related manner by 13.5-86.5%. Phenothiazine derivatives (chlorpromazine, perphenazine and trifluoperazine; 0.5-8.0 mg/kg i.v.) inhibited the caudate spindle activity only by 4.0-25.1%. The difference of central action between the two derivatives is discussed.
D000818:Animals; D002090:Butyrophenones / Q000494:pharmacology*; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects* / Q000502:physiology; D004558:Electric Stimulation; D004569:Electroencephalography; D005260:Female; D008297:Male; D010640:Phenothiazines / Q000494:pharmacology*; D011954:Receptors, Dopamine / Q000187:drug effects
D002090:Butyrophenones; D010640:Phenothiazines; D011954:Receptors, Dopamine