Antitumor effect of a combination of 6-methylthioinosine and amphotericin B on mouse leukemia L1210.
Antileukemic activity of 5 kinds of sulfur-containing purine ribonucleosides were examined in the presence and absence of amphotericin B against L1210 in mice. Among these compounds, 6-methylthioninosine was potentiated by amphotericin B. 6-Methylthioinosine in combination with amphotericin B produced a 75% increase in the lifespans, which was greater than the increase in lifespans by 6-methylthioinosine (38%) or amphotericin B alone (2%). Antitumor effects of other sulfur-containing ribonucleosides, such as 6-thiocyanatoguanine, 6-thiocyanatopurine, 6-thiocyanatoinosine, and 6-methylthiopurine, were not augmented by amphotericin B.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000666:Amphotericin B / Q000008:administration & dosage*; D000818:Animals; D004357:Drug Synergism; D007288:Inosine / Q000031:analogs & derivatives*; D007939:Leukemia L1210 / Q000188:drug therapy*; D008297:Male; D008778:Methylthioinosine / Q000008:administration & dosage*; D051379:Mice; D011684:Purine Nucleosides / Q000008:administration & dosage; D013936:Thymidine / Q000378:metabolism
D000276:Adjuvants, Immunologic; D011684:Purine Nucleosides; D008778:Methylthioinosine; D007288:Inosine; D000666:Amphotericin B; D013936:Thymidine