Effect of chloroquine and mepacrine on the spontaneous and evoked movements of the rat portal vein.
It has been known that chloroquine and mepacrine, through their parasympatholytic and spasmolytic effects, inhibit the gastric motility in rats. In the present study these drugs were shown to prevent by virtue of their antispasmodic property the spontaneous and induced movements in the isolated portal vein of the rat. As measured on isolated fundus strips of the stomach, chloroquine and mepacrine possessed almost the same pD'2 as had papaverine and drotaverine on the isolated portal vein. Chloroquine and mepacrine as well as the drugs used for comparison administered in vivo into the small intestine reached such concentrations in the portal vein blood which were shown to be capable of inhibiting the spontaneous and evoked movements in vitro.
D000818:Animals; D002738:Chloroquine / Q000378:metabolism / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D009638:Norepinephrine / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology; D010277:Parasympathomimetics / Q000037:antagonists & inhibitors; D010646:Phentolamine / Q000494:pharmacology; D011169:Portal Vein / Q000187:drug effects* / Q000502:physiology; D011796:Quinacrine / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats
D010276:Parasympatholytics; D010277:Parasympathomimetics; D002738:Chloroquine; D011796:Quinacrine; D009638:Norepinephrine; D004837:Epinephrine; D010646:Phentolamine