Conservative treatment with ketoacid and amino acid supplemented low-protein diets in chronic renal failure.
Twenty-six patients with advanced renal failure (glomerular filtration rate less than 6 ml/min) were treated with a mixed quality low protein diet and ketoacid analogues. An improvement in nitrogen balance, serum transferrin and phosphate, and base excess was observed after 2 weeks of treatment. In a longer term study, the result of 20 patients treated with ketoacids for up to 14 months were compared to a group 40 patients who received a low-protein diet with essential amino acids. Patients responded similarly to the two diets; however, the group receiving ketoacids had a significantly lower glomerular filtration rate. There was improvement in calcium and phosphate metabolism with ketoacid treatment. The patients were able to tolerate treatment with both the ketoacids and vitamin D.
D000328:Adult; D000368:Aged; D000596:Amino Acids / Q000627:therapeutic use*; D001769:Blood; D004032:Diet; D004044:Dietary Proteins; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007651:Keto Acids / Q000627:therapeutic use*; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009584:Nitrogen / Q000378:metabolism; D010710:Phosphates / Q000097:blood; D014168:Transferrin / Q000032:analysis
D000596:Amino Acids; D004044:Dietary Proteins; D006454:Hemoglobins; D007651:Keto Acids; D010710:Phosphates; D014168:Transferrin; D009584:Nitrogen