Do amino acids reverse the sickling of erythrocytes containing hemoglobin S?
Homoserine, asparagine and glutamine do not restore the deformability of deoxygenated sickle cells in spite of noticeable morphological changes. These amino acids also do not raise the minimum gelling concentration of deoxyhemoglobin S. The use of these compounds as anti-sickling agents is therefore doubtful.
D000596:Amino Acids / Q000627:therapeutic use*; D000755:Anemia, Sickle Cell / Q000188:drug therapy*; D000986:Antisickling Agents; D001777:Blood Coagulation; D003080:Cold Temperature; D005374:Filtration / Q000379:methods; D005782:Gels; D006451:Hemoglobin, Sickle / Q000627:therapeutic use*; D006801:Humans
D000596:Amino Acids; D000986:Antisickling Agents; D005782:Gels; D006451:Hemoglobin, Sickle