Glucagon suppressed proliferation rate of mammary aplastic carcinoma in mice.
Glucagon injected into mice with mammary aplastic carcinoma retards the growth and prolongs the mean survival time of the animals. Glucagon stimulates the plaque-forming capacity and phagocytosis in tumor-bearing animals. Cyclophosphamide treatment abolishes the antitumor effect of glucagon, while the effect of the hormone is enhanced in Corynebacterium parvum pretreated animals. It follows that the tumor-retarding effect of glucagon are mediated by mainly by maintaining high B-type reactivity and phagocytosis.
D000276:Adjuvants, Immunologic; D000818:Animals; D000970:Antineoplastic Agents; D003520:Cyclophosphamide / Q000494:pharmacology; D005260:Female; D005934:Glucagon / Q000627:therapeutic use*; D008321:Mammary Glands, Animal / Q000378:metabolism; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy / Q000401:mortality; D051379:Mice; D010587:Phagocytosis; D011425:Propionibacterium acnes / Q000276:immunology
D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D005934:Glucagon