title: Orally active cephalosporins and penicillins.
abstract: A number of orally active cephalosporins and penicillins with interesting biological activity were synthesized. Two of these, 7-[[[3,4-(methylenedioxy)phenyl]glycyl]amino]deacetoxycephalosporanic acid and 7-[[2-(2,3-dihydro-5-benzofuranyl)glycyl]amino]deacetoxycephalosporanic acid were considerably more active than cephalexin both in vitro and in vivo against staphylococcal and streptococcal infections.
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001424:Bacterial Infections / Q000188:drug therapy; D002511:Cephalosporins / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D007279:Injections, Subcutaneous; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D010406:Penicillins / Q000008:administration & dosage / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D002511:Cephalosporins; D010406:Penicillins