title: Placental transfer and pharmacokinetics of primidone and its metabolites phenobarbital, PEMA and hydroxyphenobarbital in neonates and infants of epileptic mothers.
mesh_terms: D000328:Adult; D000632:Aminopyrine / Q000378:metabolism; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D004827:Epilepsy / Q000188:drug therapy; D005260:Female; D006207:Half-Life; D006801:Humans; D006900:Hydroxylation; D007223:Infant; D007231:Infant, Newborn; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D008297:Male; D008314:Malonates / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D010634:Phenobarbital / Q000378:metabolism*; D010657:Phenylethylmalonamide / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy; D011324:Primidone / Q000378:metabolism*
chemical_list: D008314:Malonates; D000632:Aminopyrine; D011324:Primidone; D010657:Phenylethylmalonamide; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital