title: Dual effect of glutamate and aspartate on the on-center bipolar cell in the carp retina.
abstract: In on-center bipolar cells of the carp retina, glutamate and aspartate applied extracellularly by pressure injection produced hyperpolarizing potential changes. These responses were not blocked by Co2+. Examination of reversal potentials revealed two different conductance changes. One of them appears to be an increase in K+ and/or Cl- conductance and the other a decrease in Na+ conductance. The results are discussed with relation to the difference in ionic mechanisms of cone and rod inputs.
mesh_terms: D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D002347:Carps; D004573:Electrolytes / Q000378:metabolism; D005071:Evoked Potentials / Q000187:drug effects; D005971:Glutamates / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects; D012160:Retina / Q000166:cytology / Q000187:drug effects*
chemical_list: D004573:Electrolytes; D005971:Glutamates; D001224:Aspartic Acid