title: Effect of various forms of training and stimulation on the incorporation of 32P into the nuclear phosphoproteins of the rat brain.
abstract: Incorporation of 32P into acid-extractable nuclear proteins was measured in the hippocampus, caudate nucleus, rest of the brain, and liver of rats submitted to various different behavioral treatments in a shuttle-box. After 5 min of classical conditioning, of avoidance without CS-US pairing, and of avoidance with CS-US pairing (standard shuttle avoidance), there was an increased 32P uptake by acid-extractable nuclear proteins in the hippocampus and caudate nucleus. The effect disappeared between 5 and 25 min of training. After 25 min of buzzers alone, or of footshocks alone, a similar 32P uptake change was noted in the same brain structure, which raises doubts as to the specificity of the phenomenon in terms of learning mechanisms.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism; D003214:Conditioning, Classical / Q000502:physiology; D003213:Conditioning, Psychological / Q000502:physiology; D004597:Electroshock; D007858:Learning / Q000502:physiology*; D008099:Liver / Q000378:metabolism; D008297:Male; D009698:Nucleoproteins / Q000096:biosynthesis*; D010750:Phosphoproteins / Q000096:biosynthesis*; D010761:Phosphorus Radioisotopes; D051381:Rats; D013997:Time Factors
chemical_list: D009698:Nucleoproteins; D010750:Phosphoproteins; D010761:Phosphorus Radioisotopes