Bromocriptine-induced pregnancy in an acromegalic patient.
A 30-year-old acromegalic woman with amenorrhea and elevated growth hormone and prolactin levels was treated with bromocriptine. Growth hormone levels remained elevated, while prolactin levels decreased to normal. Forty days after initiating treatment the patient menstruated and conceived shortly afterward. The uneventful pregnancy terminated in delivery of a normal baby, who has been developing normally since. No changes in the size of the sella turcica or the visual field were noted during pregnancy and up to one year after delivery. Resumption of ovulatory menses is possible when treating acromegalic women with bromocriptine. Hyperprolactinemia rather than elevated growth hormone levels or reduced gonadotropins reserve is probably the cause for amenorrhea in some of the acromegalic patients.
D000172:Acromegaly / Q000150:complications*; D000328:Adult; D000568:Amenorrhea / Q000188:drug therapy*; D001971:Bromocriptine / Q000627:therapeutic use*; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006801:Humans; D007231:Infant, Newborn; D008598:Menstruation / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy; D011248:Pregnancy Complications; D011388:Prolactin / Q000097:blood
D001971:Bromocriptine; D011388:Prolactin; D013006:Growth Hormone