Vanadate-induced inhibition of sodium transport and of sodium-independent anion transport in turtle bladder.
Vanadate in the serosal bathing fluid of turtle bladders inhibits the Na+ moiety of the short-circuiting current (Isc), the anion (Cl-, HCO3-) moiety of Isc, and net Cl- flux. Since the anion transport is Na+-independent and ouabain-insensitive, its inhibtion by vanadate is uniquely different from the well known vanadate-induced inhibition of (Na++K+)-ATPase and Na+ transport-dependent anion movement of some other epithelia. Vanadate also generates damped oscillations in the bladders' electrical parameters, an unusual effect by an ion in epithelial systems.
D000818:Animals; D000838:Anions; D001692:Biological Transport / Q000187:drug effects; D004594:Electrophysiology; D012964:Sodium / Q000378:metabolism*; D014426:Turtles / Q000378:metabolism*; D001743:Urinary Bladder / Q000378:metabolism*; D014639:Vanadium / Q000494:pharmacology*
D000838:Anions; D014639:Vanadium; D012964:Sodium