Behavioral effects of prenatal ethanol exposure and differential early experience in rats.
Offspring of rats that were intubated with ethanol during Days 10--14 of gestation and offspring in two control groups were compared on measures of growth, viability, and performance in behavioral tasks. Influences of postnatal environment were assessed by using fostering-cross fostering procedures and by providing different postweaning housing conditions. Results were that offspring from dams treated with ethanol displayed prenatal and postnatal growth deficiency as well as increased postnatal mortality. In the open field, offspring in the Ethanol group were more active than those in the other two groups. Ethanol offspring were also more active in the Y maze and made more avoidance responses and correct discriminations. Early experience as manipulated by the fostering-cross fostering procedures and post-weaning rearing conditions had no impact on the effects of prenatal ethanol on offspring growth, viability, or behavior.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects*; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology* / Q000633:toxicity; D005260:Female; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D009043:Motor Activity / Q000187:drug effects; D011247:Pregnancy; D011287:Prejudice / Q000187:drug effects; D051381:Rats
D000431:Ethanol