[Electron microscopic study of the morphology of Brucella and of the mechanism of their phagocytosis by blood cells].
Comparative electron microscopic investigations of Brucella were carried out in cultures in vitro and in vivo in guinea pigs with experimental brucellosis (blood) and in patients with brucellosis. Morphological differences in the structure of brucella due to different environments were found. The authors discuss facultative intracellular parasitism with intraphagosomal reproduction of the causative agent. This form of incompleted phagocytosis is a morphological manifestation of decreased defence properties of cells and causes the development of persistent infection with severe bacteriotoxemia. This is an important factor of the pathogenicity of this agent and underlies the pathogenesis of brucellosis.
D000208:Acute Disease; D000818:Animals; D001770:Blood Bactericidal Activity; D002002:Brucella / Q000648:ultrastructure*; D002006:Brucellosis / Q000276:immunology / Q000382:microbiology; D006168:Guinea Pigs; D006801:Humans; D066298:In Vitro Techniques; D008854:Microscopy, Electron; D010587:Phagocytosis
Elektronno-mikroskopicheskoe issledovanie morfologii brutsell i mekhanizma fagotsitoza ikh kletkami krovi.