Treatment of primary and secondary syphilis. Serological response.
One hundred thirty-eight patients with primary syphillis and 161 patients with secondary syphilis were treated with penicillin G benzathine, 2.4 million units given intramuscularly weekly for two weeks, for a total of 4.8 million units. All 138 patients with primary syphilis had a rapid resolution of their lesions, and all became seronegative within one year. Similarly, the 161 patients with secondary syphilis were cured clinically, and all achieved seronegativity within 24 months.
D000284:Administration, Oral; D000328:Adult; D002601:Chancre / Q000188:drug therapy; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D010401:Penicillin G Benzathine / Q000008:administration & dosage / Q000627:therapeutic use*; D013587:Syphilis / Q000188:drug therapy*; D013754:Tetracyclines / Q000627:therapeutic use
D013754:Tetracyclines; D010401:Penicillin G Benzathine