Stability of apomorphine in solutions containing ascorbic acid and bisulfite and effects of antioxidants on apomorphine-induced cage climbing and hypothermia in mice.
Ascorbic acid (100 mg/ml) and sodium bisulfite (0.5 and 20 mg/ml) prevented more than 10% oxidation of apomorphine hydrochloride in water maintained at room temperature over 1-3 days. Refrigeration at 5 degrees prevented oxidation of apomorphine hydrochloride in aqueous solutions for 1 week. Neither ascorbic acid nor sodium bisulfite affected murine stereotyped cage climbing or hypothermia induced by apaomorphine.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001058:Apomorphine / Q000032:analysis* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D004347:Drug Interactions; D004355:Drug Stability; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D013447:Sulfites / Q000494:pharmacology*
D000975:Antioxidants; D013447:Sulfites; D001058:Apomorphine; D001205:Ascorbic Acid; C009279:sodium bisulfite