Gentisic acid: a new stabilizer for low tin skeletal imaging agents: concise communication.
In vitro stabilization of low-tin bone-imaging agents has previously been achieved with ascorbic acid. In this study gentisic acid is shown to be an equally effective antioxidant for the (1-hydroxyethylidene) diphosphonate (HEDP) and hydroxymethylenediphosphonate (HMDP) skeletal agents. In vitro studies show less than 2% free sodium [99mTc] pertechnetate at 24 hr with the gentisic acid stabilizer. Studies in guinea pigs at 3 and 24 hr--whether with C-14 or H-3-labeled gentisic acid as stabilizer--show no alteration in the biodistribution of either skeletal imaging agent by the addition of the gentisic acid. Gentisic acid is a safe and effective stabilizer, and clinical studies have shown bioequivalency with ascorbic acid.
D000818:Animals; D000975:Antioxidants; D001205:Ascorbic Acid / Q000378:metabolism; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D002614:Chelating Agents / Q000378:metabolism; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D005841:Gentisates / Q000378:metabolism; D006168:Guinea Pigs; D007275:Injections, Intravenous; D011877:Radionuclide Imaging / Q000379:methods; D013667:Technetium / Q000378:metabolism; D013997:Time Factors; D014001:Tin; D014018:Tissue Distribution
D000975:Antioxidants; D002614:Chelating Agents; D005841:Gentisates; D013667:Technetium; D014001:Tin; D001205:Ascorbic Acid