title: Role of chloramphenicol reduction products in aplastic anemia.
abstract: Oral administration of chloramphenicol did not significantly alter the early stage of chronic hypoplastic marrow failure induced by busulfan. Chloramphenicol reduction products were most suppressive to antigen-reactive cells detected by the Mishell-Dutton plaque-forming cell assay. This reduction in immunocompetence may be an important parameter in the initial phases of the etiology of chloramphenicol-induced aplastic anemia.
mesh_terms: D000741:Anemia, Aplastic / Q000139:chemically induced*; D000818:Animals; D001711:Biotransformation; D001854:Bone Marrow Cells; D002701:Chloramphenicol / Q000009:adverse effects* / Q000378:metabolism; D003114:Colony-Forming Units Assay; D004912:Erythrocytes / Q000276:immunology; D005260:Female; D006413:Hematopoietic System / Q000166:cytology; D051379:Mice; D008815:Mice, Inbred Strains; D008934:Mitogens / Q000494:pharmacology; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology
chemical_list: D008934:Mitogens; D002701:Chloramphenicol