Effects of selective ultraviolet phototherapy (SUP) and local PUVA treatment on DNA synthesis in guinea pig skin.
The treatment with UV-light with wavelengths between 292.5--335 nm (known as selective UV-phototherapy, or SUP) and 320--390 nm (plus local treatment with 8-methoxypsoralen, known as PUVAex) gave rise to a biphasic reaction of epidermal cell proliferation in guinea pig skin. A decrease of proliferative activity was followed by a synchronized stimulation of DNA synthesizing cells after 2--4 h. These quantitative displacements were accompanied by qualitative changes in the proliferative behaviour of epidermal cells in the S-compartment.
D000818:Animals; D002455:Cell Division / Q000187:drug effects / Q000528:radiation effects; D004247:DNA / Q000096:biosynthesis; D006168:Guinea Pigs; D008297:Male; D008730:Methoxsalen / Q000009:adverse effects*; D010778:Photochemotherapy / Q000009:adverse effects*; D012867:Skin / Q000166:cytology / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays / Q000009:adverse effects
D004247:DNA; D008730:Methoxsalen