Phenytoin pharmacokinetic analysis and steady-state level prediction using a programmable calculator.
This paper describes the use of a programmable calculator (HP-97) to determine the individualized Michaelis-Menten parameters of phenytoin by utilising the linear regression technique in fitting data of multiple doses and corresponding steady-state concentrations to a linear-transformed Michaelis-Menten equation and solving for the Michaelis-Menten parameters. In addition, the calculator program can predict the corresponding steady-state concentration of phenytoin for any given dose used in an individual by employing the derived Michaelis-Menten parameters and the Michaelis-Menten equation.
D003201:Computers; D005544:Forecasting; D006801:Humans; D007700:Kinetics; D008954:Models, Biological; D010672:Phenytoin / Q000008:administration & dosage / Q000378:metabolism*
D010672:Phenytoin