Evaluation of the photocontact allergenic potential of 6-methylcoumarin in the guinea pig.
6-Methylcoumarin was tested in a new animal model developed for the predictive evaluation of photocontact allergenic potential. Negative results were obtained and these are discussed with respect to inherent limitations of the animal model.
D000485:Allergens; D000818:Animals; D003374:Coumarins / Q000494:pharmacology*; D003876:Dermatitis, Atopic / Q000139:chemically induced*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D006168:Guinea Pigs; D007114:Immunization; D008297:Male; D010787:Photosensitivity Disorders / Q000139:chemically induced* / Q000276:immunology; D012882:Skin Tests
D000485:Allergens; D003374:Coumarins; C018096:6-methylcoumarin