title: Inhibition of lordotic behavior in female rats following intracerebral infusion of anticholinergic agents.
abstract: Cholinergic antagonists were bilaterally infused into forebrain areas of ovariectomized female rats brought into sexual receptivity by administration of estrogen and progesterone. Infusion of hemicholinium-3 (HG-3, 5 or 7.5 micrograms/cannula), an acetylcholine synthesis inhibitor believed to interfere with choline uptake, decreased the incidence of lordotic behavior displayed by females. This inhibition was prevented by infusion of choline chloride (120 micrograms/cannula) along with HC-3. Atropine sulfate, an acetylcholine receptor blocker, also reduced lordotic behavior in females following intracerebral infusion (20 micrograms/cannula). These results lend support to the suggestion that lordotic behavior is facilitated by central cholinergic activity.
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002369:Castration; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D006426:Hemicholinium 3 / Q000494:pharmacology; D007276:Injections, Intraventricular; D010276:Parasympatholytics / Q000008:administration & dosage / Q000494:pharmacology*; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013997:Time Factors
chemical_list: D004967:Estrogens; D010276:Parasympatholytics; D006426:Hemicholinium 3; D011374:Progesterone; D001285:Atropine