Synthesis of pimeloyl coenzyme A.
Synthesis of pimeloyl CoA based on the reaction of N-hydroxysuccinimide ester of pimelic acid and coenzyme A in the presence of sodium hydroxide is reported. The CoA derivative has been isolated, purified and fully characterized from its chemical properties and spectral data. The yields are superior to acid chloride, anhydride or ester exchange methods due to lack of side reactions.
D000214:Acyl Coenzyme A / Q000138:chemical synthesis*; D004228:Dithionitrobenzoic Acid; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010867:Pimelic Acids / Q000138:chemical synthesis; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013388:Succinimides
D000214:Acyl Coenzyme A; D010867:Pimelic Acids; D013388:Succinimides; C019527:pimeloyl-coenzyme A; D004228:Dithionitrobenzoic Acid; C001426:N-hydroxysuccinimide