title: On some derivatives of ferrocene, novel acetylcholinesterase inhibitors.
abstract: Eight novel methylcarbamates, derivates of ferrocenylketoximes and aldoximes, and ferrocenyl-p-hydroxyphenylaldimine were prepared. They are the first carbamates in the field of ferrocene derivatives. Their anticholinesterase activity was tested and found to fall in the range of 10(-4) through 10(-6) M (I50). The correlation between the activity of the compounds and the kind of substituents grafted on the methylene carbon atom is discussed.
mesh_terms: D000110:Acetylcholinesterase / Q000032:analysis; D002800:Cholinesterase Inhibitors / Q000032:analysis*; D005296:Ferrous Compounds / Q000032:analysis*; D007501:Iron / Q000032:analysis*; D000075163:Metallocenes; D009942:Organometallic Compounds / Q000032:analysis*; D013329:Structure-Activity Relationship
chemical_list: D002800:Cholinesterase Inhibitors; D005296:Ferrous Compounds; D000075163:Metallocenes; D009942:Organometallic Compounds; D007501:Iron; D000110:Acetylcholinesterase; C004998:ferrocene