Successful pregnancy in an abortion-prone woman: prostaglandin and hormone levels during implantation, gestation and lactation.
Serum progesterone, human chorionic gonadotropin, prostaglandin E2, F2 alpha and 13,14-dihydro-15-keto-PGF2 alpha and urinary immunoractive prostaglandins E2 and F2 alpha were measured throughout gestation in a woman who previously had experienced three abortions, an immature birth of a twin and a term single pregnancy. Prostaglandin-mediated symptoms such as uterine sensitivity and contractions, backache, spotting, vomiting and diarrhea were carefully registered and have been correlated with the variations in prostaglandin levels. The effect of therapy with a prostaglandin synthetase inhibitor and a beta-adrenergic drug on prostaglandin levels was also studied. The rise of prostaglandin E2 level observed during implantation is discussed.
D000022:Abortion, Spontaneous; D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood*; D003338:Corpus Luteum / Q000502:physiology; D015237:Dinoprost / Q000031:analogs & derivatives*; D010064:Embryo Implantation; D005260:Female; D006801:Humans; D007774:Lactation; D011247:Pregnancy; D011374:Progesterone / Q000097:blood*; D011453:Prostaglandins / Q000097:blood* / Q000652:urine; D011458:Prostaglandins E / Q000097:blood; D011460:Prostaglandins F / Q000097:blood*
D006063:Chorionic Gonadotropin; D011453:Prostaglandins; D011458:Prostaglandins E; D011460:Prostaglandins F; C008228:15-keto-13,14-dihydroprostaglandin F2alpha; D011374:Progesterone; D015237:Dinoprost