Effect of benzyl nicotinate on the percutaneous absorption of dexamethasone in the rat.
The effect of benzyl nicotinate (15 mg) on the percutaneous absorption of dexamethasone 0,1 mg (62,5 uCi)/6 cm2, in an ethanol/octanol vehicle has been investigated in the rat. Both the urinary excretion and blood concentration data showed that benzyl nicotinate had a pronounced stimulating effect on the rate and extent of absorption. The relative bioavailability of dexamethasone was found to be 120% (urinary excretion data) or 146% (blood concentration data). Peak blood concentration increased greatly and was reached more quickly (1 1/2 hours instead of 2 1/2 hours).
D000818:Animals; D001682:Biological Availability; D001775:Blood Circulation / Q000187:drug effects*; D003907:Dexamethasone / Q000097:blood / Q000378:metabolism* / Q000652:urine; D004347:Drug Interactions; D008297:Male; D009539:Nicotinic Acids / Q000494:pharmacology*; D051381:Rats; D012869:Skin Absorption / Q000187:drug effects*; D013997:Time Factors
D009539:Nicotinic Acids; D003907:Dexamethasone; C025653:nicotinic acid benzyl ester