Ligand interaction of sustituted pyridines with cytochrome P-450.
A series of pyridyl ketones and alkyl pyridines was evaluated as type II ligands for cytochrome P-450. Activity as type II ligands was evaluated in terms of the lipid solubility and the pKa values of the compounds.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006418:Heme / Q000378:metabolism; D007659:Ketones; D007700:Kinetics; D008024:Ligands; D008099:Liver / Q000378:metabolism; D008297:Male; D011725:Pyridines / Q000378:metabolism*; D051381:Rats; D012995:Solubility
D007659:Ketones; D008024:Ligands; D011725:Pyridines; D006418:Heme; D003577:Cytochrome P-450 Enzyme System