[Central choline-potentiating effect of amizil].
The effect of the central anticholinergic agent benactizin on cholinoreactivity of rats was evaluated by determination of ED50 of arecolin. ED50 of arecoline rose with increase in the dose of benactizin from 1 to 40 mg/kg. In a dose of 0.2 mg/kg benactizin elicited a pronounced statistically significant cholinopotentiating action that lasted about 5 hours. In a dose of 1 mg/kg the drug exerted an anticholinergic effect followed by cholinopotentiating action.
D000818:Animals; D001115:Arecoline / Q000037:antagonists & inhibitors*; D001535:Benactyzine / Q000008:administration & dosage / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D010277:Parasympathomimetics; D010525:Peripheral Nerves / Q000187:drug effects*; D051381:Rats; D013997:Time Factors
D010277:Parasympathomimetics; D001115:Arecoline; D001535:Benactyzine
O tsentral'nom kholinopotentsiruiushchem deĭstvii amizila.