title: [Production of a murine lymphadenosis NK/LY resistant to rubomycin and a comparison of the cellular DNA histograms of the sensitive and resistant lines].
abstract: Lymphadenosis NK/LY resistant to rubomycin was obtained on its repeated cultivation in mice treated with the antibiotic. The rubomycin resistance was stable and preserved for a long period of time when the line was repeatedly cultivated in mice not exposed to the antibiotic. The tumor cells resistant to rubomycin acquired resistance to olivomycin. DNA histograms of the tumor cells obtained by means of impulse cytophotometry provided determination of the tumor sensitivity and resistance to antitumor agents. It is recommended that impulse cytophotometry be used for the screening of antitumor drugs and development of their administration regimen.
mesh_terms: D000818:Animals; D002460:Cell Line; D004273:DNA, Neoplasm / Q000032:analysis*; D003630:Daunorubicin / Q000037:antagonists & inhibitors*; D004305:Dose-Response Relationship, Drug; D004351:Drug Resistance; D008223:Lymphoma / Q000188:drug therapy*; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D009848:Olivomycins / Q000037:antagonists & inhibitors; D013997:Time Factors
chemical_list: D004273:DNA, Neoplasm; D009848:Olivomycins; D003630:Daunorubicin
vernacular_title: Poluchenie limfadenoza mysheĭ NK/LY, ustoĭchivogo k rubomitsinu, i sravnenie DNK-gistogramm kletok chuvstvitel'noĭ i ustoĭchivoĭ liniĭ.