Effects of oral feeding of mite antigen upon production of homocytotropic antibodies.
Effect of oral administration of mite antigen was studied in homocytotropic antibody production in mice. Anti-mite IgE and IgG, antibodies were undetectable if the large amount of mite antigen was given prior to primary immunization. It was noted that the larger the dosage given the more clearly the suppression of homocytotropic antibody production was obtained and the shorter the interval between feeding and primary immunization the more marked tolerance was induced. No significant effect was observed by oral administration of antigen in on-going homocytotropic antibodies.
D000375:Aging; D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage*; D004136:Dinitrobenzenes / Q000276:immunology; D004435:Eating; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008925:Mites
D000941:Antigens; D004136:Dinitrobenzenes; D007074:Immunoglobulin G; D007073:Immunoglobulin E