title: [Familial malignant melanoma and atypical disseminated moles (BK-mole syndrome)].
abstract: Report of a family with malignant melanomas and multiple atypical pigmented moles in three siblings. A 29 year old caucasian woman had a nodular melanoma. Twelve years ago, at the age of 23, her elder brother had been suffering from a melanoma with a solitary cerebral metastasis. Following radical surgical treatment, he has been well since that time. Their sister died with 21 years after inadequate treatment and generalisation of a melanoma in her temporal region. All patients had multiple atypical nevus cell nevus-like pigmented moles with irregular bizarre configuration, especially in the upper parts of the trunk. These findings correspond to the BK-mole syndrome. This heritable syndrome is not frequent, but important because of the necessity to keep all relatives of BK-mole patients under continuous dermatological control and to remove each suspicious lesion early enough.
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000473:pathology; D009508:Nevus, Pigmented / Q000235:genetics* / Q000473:pathology; D012878:Skin Neoplasms / Q000235:genetics* / Q000473:pathology; D013577:Syndrome
vernacular_title: Familiäre maligne Melanome und atypische disseminierte Pigmentale (BK-Mole-Syndrom).