title: [Neuropsychologic evaluation of the action of oxovinca in the syndrome of diffuse deterioration of vascular origin (author's transl)].
abstract: A controlled double-blind study of the effects of oxovinca in the syndrome of diffuse deterioration of vascular origin has been carried out. The measurement and follow-up the degree of deterioration has been done by application of a new scale. The subjects of the study were divided into an experimental sample (formed by 33 patients) and a placebo sample (formed by 6 patients), all with the syndrome of diffuse deterioration of vascular origin, and a control sample formed by 10 normal individuals of comparable age. After three consecutive courses of the drug given within a two-month period to the experimental and placebo groups, and comparing the results with those of the control sample, the statistical analysis of the data demonstrates that, given the temporal limitations of the trial, a partial reversibility of the signs and symptoms of the syndrome of diffuse deterioration is possible and correlates with the therapeutic action of oxovinca.
mesh_terms: D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D002561:Cerebrovascular Disorders / Q000150:complications; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D019965:Neurocognitive Disorders / Q000175:diagnosis / Q000188:drug therapy*; D010919:Placebos; D011581:Psychological Tests; D014748:Vinca Alkaloids / Q000627:therapeutic use*; D014749:Vincamine / Q000031:analogs & derivatives / Q000627:therapeutic use*
chemical_list: D000925:Anticoagulants; D010919:Placebos; D014748:Vinca Alkaloids; D014749:Vincamine; C026347:oxovinca
vernacular_title: Valoración neuropsicológica de la acción de oxovinca en el sindrome de deterioro difuso de origen vascular.