Live attenuated rubella virus vaccine: comparison of responses to HPV-77-DE5 and RA 27/3 strains.
The responses of seronegative adults to two live attenuated rubella virus vaccines were compared. Of 50 women who received the HPV-77-DE5 strain, 49 (98%) had an antibody response; the geometric mean antibody titer (GMT) was 1:38 at two to five months and 1:59 at six to 14 months. Of 66 women and three men who received the RA 27/3 strain all (100%) had an antibody response; the GMT was 1:55 at two to five months and 1:75 at six to 14 months. The incidence of mild to moderate transient clinical reactions, occurring in approximately one-fourth of those vaccinated, was similar for both groups. The serologic response to both vaccines was excellent.
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012411:Rubella Vaccine / Q000009:adverse effects / Q000276:immunology*; D014613:Vaccines, Attenuated / Q000009:adverse effects / Q000276:immunology*
D000914:Antibodies, Viral; D012411:Rubella Vaccine; D014613:Vaccines, Attenuated