Long-lasting depletion of striatal dopamine by a single injection of amphetamine in iprindole-treated rats.
A single injection of amphetamine given to rats treated concurrently with iprindole so that they could not metabolize the amphetamine by para-hydroxylation resulted in a decrease in the concentration of striatal dopamine 1 week later. The decrease was antagonized by amfonelic acid, an inhibitor of uptake into dopamine neurons. The long-lasting depletion of cerebral dopamine by amphetamine may be analogous to the depletion of cerebral serotonin by halogenated derivatives of amphetamine.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism; D007211:Indoles / Q000494:pharmacology*; D007488:Iprindole / Q000494:pharmacology*; D008297:Male; D009268:Nalidixic Acid / Q000031:analogs & derivatives; D009287:Naphthyridines / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D010133:p-Chloroamphetamine / Q000494:pharmacology
D007211:Indoles; D009287:Naphthyridines; D009268:Nalidixic Acid; D010133:p-Chloroamphetamine; D007488:Iprindole; D000661:Amphetamine; C006486:amfonelic acid; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine