Pharmacokinetics of ceftezole in patients with normal and impaired renal function.
The pharmacokinetics of ceftezole, a new cephalosporin antibiotic, was studied in 15 patients with normal and impaired renal function after administering the drug in a 2-hour intravenous drip infusion of 2 g. 81% of the infused dose was excreted in the first 6 h urine of the patients with normal renal function. The pharmacokinetic parameters of ceftezole were obtained by analyzing the serum level data of the drug using a one-compartment open model. The mean serum half-life of ceftezole was 0.64 h in patients with normal renal function and was prolonged to 10.7 h in patients with severely impaired renal function (creatinine clearance: 0-2.6 ml/min.). There was a significant linear correlation between the elimination rate of the drug and creatinine clearance.
D000328:Adult; D000368:Aged; D002437:Cefazolin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D007668:Kidney / Q000502:physiology / Q000503:physiopathology; D007674:Kidney Diseases / Q000378:metabolism / Q000503:physiopathology; D007700:Kinetics; D008297:Male; D008875:Middle Aged
C012811:ceftezole; D002437:Cefazolin