Effects of atropine on the synchronization elicited by electrical stimulation of the olfactory tubercle.
The effect of repeated intravenous administration of 1 mg/kg atropine was studied on the synchronization elicited by low and high frequency electrical stimulation in the olfactory tubercle. The results showed that the synchronization of the cortical electrical activity could also be brought about during atropine administration, moreover, a gradual dose-dependent facilitation of the synchronizing effect was observed. Similar facilitation was obtained in cerveau isolé of the cats. Based on the experimental results it is concluded that the synchronizing effects of basal forebrain stimulation and the arousal effect of the activating system converge at a cortical level.
D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D002415:Cats; D003344:Cortical Synchronization; D004558:Electric Stimulation; D004569:Electroencephalography; D005260:Female; D008297:Male; D009830:Olfactory Bulb / Q000187:drug effects / Q000502:physiology*; D011950:Receptors, Cholinergic / Q000187:drug effects; D012890:Sleep / Q000502:physiology
D011950:Receptors, Cholinergic; D001285:Atropine