Studies of zinc and histamine on lysosomal fragility: possible role in stress ulceration.
A combined in vivo and in vitro study was undertaken with rats to test the hypothesis that zinc would protect against cold water immersion--restraint gastric ulcers, and that this phenomenon was mediated in part by stabilization of lysosomal membranes. This postulate was confirmed by observed activity changes in released beta-glucuronidase in mucosal tissue, as well as by dose-response in vitro data on isolated hepatic lysosomes exposed to zinc. Histamine, a known ulcer-enhancing agent, induced the opposite effect and increased the lysosomal release of this marker acid hydrolase.
D000818:Animals; D003080:Cold Temperature; D005966:Glucuronidase / Q000378:metabolism; D006632:Histamine / Q000494:pharmacology*; D007101:Immersion; D008247:Lysosomes / Q000187:drug effects*; D008297:Male; D051381:Rats; D013270:Stomach / Q000473:pathology; D013276:Stomach Ulcer / Q000209:etiology* / Q000473:pathology; D013312:Stress, Physiological / Q000150:complications*; D015032:Zinc / Q000494:pharmacology*
D006632:Histamine; D005966:Glucuronidase; D015032:Zinc