[Effect of the combined and separate administration of phenobarbital and 3-methylcholanthrene on liver benzopyrene hydroxylases in "sensitive" and "resistant" inbred mice].
Combined induction of liver monooxygenases with 3-methylcholanthrene (3-MC) and phenobarbital (PB) has been studied in experiments on DBA/2 and C57B/6 mice. As is known, PB increases the number of intracellular receptor sites for polycyclic hydrocarbons. When DBA/2 mice resistant to the induction were pretreated with PB, there were no signs of induction common to those induced by 3-MC. In similar experiments with the sensitive C57BL/6 mice, PB and 3-MC produced additive effects on the induction of liver monooxygenases.
D000818:Animals; D001189:Aryl Hydrocarbon Hydroxylases / Q000096:biosynthesis*; D001579:Benzopyrene Hydroxylase / Q000096:biosynthesis*; D004357:Drug Synergism; D004790:Enzyme Induction / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D008748:Methylcholanthrene / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL / Q000378:metabolism*; D008811:Mice, Inbred DBA / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology*
D008748:Methylcholanthrene; D001579:Benzopyrene Hydroxylase; D001189:Aryl Hydrocarbon Hydroxylases; D010634:Phenobarbital
Effekt smeshannogo i razdel'nogo vvedeniia fenobarbitala i 3-metilkholantrena na benzpirengidroksilazy pecheni "chuvstvitel'nykh" i "ustoichivykh" inbrednykh mysheĭ.