[Stimulating effect of certain chemical carcinogens on gastric organ cultures].
Results of measuring the relative growth of the area surrounding the explants of nonibred rat embryonal stomach were studied after transplacental exposure to benz(a)pyrene (BP) and N-methyl-N'-nitro-N-nitrosoguanidine (MNNG). The embryonal tissue of the rat stomach is marked by high sensitivity to the carcinogens. This was manifested in better survival of the test cultures. The magniture of the relative growth of the explants exposed to transplacental MNNG exceeded, over the same period of culture, the control measurements by 2.5--3.5 times on the average, while on transplacental administration of BP the largest growth was recorded on the 6th day.
D000818:Animals; D001580:Benzopyrenes / Q000494:pharmacology*; D005260:Female; D008431:Maternal-Fetal Exchange; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D009924:Organ Culture Techniques; D011247:Pregnancy; D051381:Rats; D013268:Stimulation, Chemical; D013270:Stomach / Q000187:drug effects* / Q000196:embryology
D001580:Benzopyrenes; D008769:Methylnitronitrosoguanidine
O stimuliruiushchem deĭstvii nekotorykh khimicheskikh kantserogenov na organnye kul'tury zheludka.