title: [Gamma teletherapy in the combined treatment of breast cancer].
abstract: The results of combination treatment in 655 breast cancer patients, who underwent pre- and postoperative gammatherapy, are reported. Radiotherapy in 522 patients was performed prior to radical mastectomy, in 133--after it. 69.5% of patients showed cancer in stage II-b, III-a, III-b. A 5-year survival was noted in 54.6%, the clinical cure (without any signs of recurrence and metastases)--in 46.2%. A comparative analysis of the 5-year cure using pre- and postoperative irradiation indicated the rationale of preoperative gamma therapy in patients with regional metastases. Thus, the 5-year cure among patients irradiated preoperatively was 81.2% in stage II-b, 67.3%--in stage III-a, 31.4%--in stage III-b versus 38.9%, 60% and 25% respectively, while using postoperative gammatherapy. Preoperative irradiation is found to contribute to nearly 4 times less incidence of local recurrences compared with the postoperative one.
mesh_terms: D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000401:mortality / Q000532:radiotherapy*; D003037:Cobalt Radioisotopes / Q000627:therapeutic use*; D005260:Female; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D009367:Neoplasm Staging; D011182:Postoperative Care; D011300:Preoperative Care; D011867:Radioisotope Teletherapy
chemical_list: D003037:Cobalt Radioisotopes
vernacular_title: Distatsionnaia gamma-terapiia v kombinirovannom lechenii raka molochnoĭ zhelezy.