Multidose studies in the human metabolism of pentobarbitone.
The metabolism of pentobarbitone has been investigated in two healthy volunteers, and the urinary excretion of unchanged drug, and the products of omega- and (omega-1)-oxidation, quantified for four days after each of three doses to each volunteer. The rates of excretion are discussed in terms which include enzyme induction effects.
D001711:Biotransformation; D006801:Humans; D006900:Hydroxylation; D007700:Kinetics; D008297:Male; D010084:Oxidation-Reduction; D010424:Pentobarbital / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine
D010424:Pentobarbital