Effect of phthalic acid esters on mouse testes.
Effects of three phthalic acid esters (PAEs) on mouse testes are described and discussed. Zinc concentrations in the testes of mice fed a diet containing 2% dibutyl (DBP), di-iso-butyl (DIBP) or di-2-ethylhexyl phthalate (DEHP) were less than those of control animals. Testosterone concentrations in the testes were decreased in DEHP-treated mice, and the relative testis weight of DBP-, DIBP- and DEHP-treated mice was increased.
D000818:Animals; D003993:Dibutyl Phthalate / Q000633:toxicity / Q000031:analogs & derivatives; D004051:Diethylhexyl Phthalate / Q000633:toxicity; D008297:Male; D051379:Mice; D010795:Phthalic Acids / Q000633:toxicity*; D013737:Testis / Q000187:drug effects*; D013739:Testosterone / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
D010795:Phthalic Acids; D003993:Dibutyl Phthalate; D013739:Testosterone; D004051:Diethylhexyl Phthalate; C025605:diisobutyl phthalate; D015032:Zinc