[Persistance of fetal circulation. a case associated to maternal indomethacin administration (author's transl)].
The case of a neonate born to a mother who was treated with indomethacin in the antenatal period is presented. Newborn presented, immediately after birth, severe respiratory distress syndrome, with cyanosis that remain unmodified by oxigenotherapy and mechanical ventilation. Clinical picture and analitic and radiographic findings, suggested persistent fetal circulation syndrome. It has been recently demonstrated that indomethacin is able to affect hemodynamic changes in neonatal period avoiding arteriolar dilatation and consequently, the fall of pulmonary vascular resistences. Administration of tolazoline was followed of rapidly improvement of the patient.
D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007213:Indomethacin / Q000009:adverse effects*; D007231:Infant, Newborn; D007743:Labor, Obstetric / Q000187:drug effects; D008297:Male; D010547:Persistent Fetal Circulation Syndrome / Q000139:chemically induced*; D011247:Pregnancy; D011448:Prostaglandin Antagonists; D011453:Prostaglandins / Q000096:biosynthesis; D012127:Respiratory Distress Syndrome, Newborn / Q000139:chemically induced
D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D007213:Indomethacin
Persistencia de la circulación fetal. A propósito de un caso asociado a tratamiento materno con indometacina.