Natural history of diethylstilbestrol-associated genital tract lesions: Cervical ectopy and cervicovaginal hood.
There was a marked regression of structural abnormalities associated with in utero exposure to diethylstilbestrol (DES) among 173 women observed for up to 5 years. Cervical ectopy, present in 121 women at initial examination, decreased in extent in 91 women (75.2%) and disappeared completely in 38 (31.4%). The cervicovaginal hood (CVH), present initially in 123 women, diminished in 65 patients (52.8%) and disappeared completely in 35 (28.4%). The longer the follow-up period, the greater the extent of resolution of these lesions. Patients with both findings at entry into the study showed parallel diminution of ectopy and CVH. The investigation documents that DES-associated ectopy and CVH are labile lesions which tend to decrease in extent with time and may eventually disappear.
D000293:Adolescent; D000328:Adult; D002648:Child; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013997:Time Factors; D002577:Uterine Cervical Diseases / Q000139:chemically induced* / Q000473:pathology; D014621:Vagina / Q000473:pathology; D014623:Vaginal Diseases / Q000139:chemically induced* / Q000473:pathology
D004054:Diethylstilbestrol