Nonrandom chromosome changes in nine rat liver epithelial cell lines.
Using G-banding technique, the karyotypes of nine liver epithelial cell lines from Wistar rats cultivated under standard conditions were studied in early successive passages. Preferential involvement of chromosome n 1 abnormalities including numerical and structural changes appeared at about the 14th passage. These apparently nonrandom chromosome changes have been compared with those found in neoplastic cell lines.
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002875:Chromosomes; D004848:Epithelium; D007621:Karyotyping; D008099:Liver; D011003:Ploidies; D051381:Rats; D014178:Translocation, Genetic; D014314:Trisomy