Alterations in pharmacological responses of rabbit skeletal muscle by reserpine pretreatment.
In the present study the isolated phrenic nerve-diaphragm preparation from rabbits pretreated with reserpine was used. Isometric twitch tension response was recorded. Concentration-response curves which demonstrated the neuromuscular blocking activity of d-tubocurarine were constructed. Curarized diaphragms were directly stimulated and concentration-response curves were made which demonstrated caffeine's ability to potentiate twitch tension. Pretreatment of rabbits with reserpine resulted in a potentiation of the effects of d-tubocurarine and caffeine. The present data indicate that pretreatment of rabbits with reserpine resulted in alteration of the in vitro responses of skeletal muscle to d-tubocurarine and caffeine.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D003964:Diaphragm / Q000502:physiology; D004347:Drug Interactions; D004558:Electric Stimulation; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D011817:Rabbits; D012110:Reserpine / Q000494:pharmacology*; D014403:Tubocurarine / Q000494:pharmacology
D002110:Caffeine; D012110:Reserpine; D014403:Tubocurarine