Synthesis of DNA by Micrococcus luteus is resistant to 6-(p-hydroxyphenylazo)uracil.
The DNA synthesis inhibitor 6-(p-hydroxyphenylazo)uracil (HPUra), at concentrations ranging from 0.2 to 2000 micro M, had essentially no effect on DNA synthesis in Micrococcus luteus strain ML-1. Seven other M. luteus strains were unaffected by 200 micro M HPUra. In vitro DNA synthesis in toluene-treated M. luteus strain ML-1 ws resistant to both HPUra and reduced HPUra.
D000255:Adenosine Triphosphate / Q000494:pharmacology; D004269:DNA, Bacterial / Q000096:biosynthesis*; D003854:Deoxyribonucleotides / Q000494:pharmacology; D004229:Dithiothreitol / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006906:Hydroxyphenylazouracil / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D008837:Micrococcus / Q000187:drug effects / Q000378:metabolism*; D014498:Uracil / Q000031:analogs & derivatives*
D004269:DNA, Bacterial; D003854:Deoxyribonucleotides; D006906:Hydroxyphenylazouracil; D014498:Uracil; D000255:Adenosine Triphosphate; D008274:Magnesium; D004229:Dithiothreitol