Unique toxic lesions induced by chemical carcinogens in rodents: indications of a short-term bioassy for carcinogenesis testing of environmental chemicals.
Many chemical carcinogens induce toxic nonneoplastic lesions relatively quickly (hours to weeks) in rodent tissues frequently the site of subsequent neoplasms, many months later. Although many of these toxic lesions are nonspecific, several unique lesions are induced almost entirely be carcinogens. Most commonly they are seen in rodent liver, kidney, thyroid and urinary bladder. If these lesions are induced in vivo by a chemical under safety testing, they may be predictive for future cancer development.
D000818:Animals; D002273:Carcinogens; D056486:Chemical and Drug Induced Liver Injury; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006965:Hyperplasia / Q000139:chemically induced; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D051381:Rats; D013961:Thyroid Gland / Q000473:pathology*; D001745:Urinary Bladder Diseases / Q000139:chemically induced* / Q000473:pathology
D002273:Carcinogens