Warfarin anticoagulation in the horse.
The hematologic and clinical effects of anticoagulation with warfarin were documented in 4 horses. All of the animals had thrombophlebitis (external jugular vein). Measures of coagulation were monitored, with a prothrombin time of 1.5 to 2.5 x base-line value being used as the effective range of anticoagulation. Recanalization was achieved in 2 of 4 cases. Hemorrhage, both subcutaneous and through a surgical incision, was a complication. Vitamin K1, an antidote to warfarin toxicosis, was administered intravenously to reverse anticoagulation and to control hemorrhage.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D001779:Blood Coagulation Factors; D005260:Female; D006470:Hemorrhage / Q000209:etiology / Q000662:veterinary; D006736:Horses; D008297:Male; D014812:Vitamin K / Q000494:pharmacology; D014859:Warfarin / Q000009:adverse effects / Q000494:pharmacology*
D001779:Blood Coagulation Factors; D014812:Vitamin K; D014859:Warfarin