title: Evaluation of growth rate of human transitional cell tumors according to sex chromatin (Barr bodies) content.
abstract: In 53 women with urothelial tumors of the bladder, renal pelvis and ureter of different in growth stages and grades of differentiation, a negative correlation among the value of the mitotic index and sex chromatin content was found. With a decrease in the number of nuclei containing sex chromatin bodies we have noted not only a proportional mitotic index increase but also a regular connected decrease of histological differentiation and a deeper invasion of the tumor. The significance of this simple test consists in the fact that one may judge the rate of tumor growth by the sex chromatin content in a small volume of biopsy material. A table of mitotic index values depending upon the quantity of nuclei with sex chromatin bodies in transitional cell tumors is presented.
mesh_terms: D002295:Carcinoma, Transitional Cell / Q000503:physiopathology / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D008940:Mitotic Index; D009361:Neoplasm Invasiveness; D012728:Sex Chromatin / Q000648:ultrastructure; D014571:Urologic Neoplasms / Q000503:physiopathology / Q000648:ultrastructure*