[Effects of nifedipine on lactate metabolism in ischemic cardiopathy. Evaluation by atrial pacing].
10 patients with documented ischaemic heart disease were undergone to atrial pacing (AP) before and after administration of nifedipine. The lactate utilization (%L), ischaemic ST, angor were tested in the same conditions before and after the drug. Six patients presented negative lactate utilization (-%L) during AP before the drug and four had decreased %L during recovery. -%L was removed by the drug, in those without -%L nifedipine is able to provocate the same paradoxically. Nevertheless angor disappears n all cases while the ischaemic ST is irregulary eliminated. Paradoxical -%L after nifedipine was not assumed as result of damage of the coronary flow, as ischaemic ST and angor disappear. Probably this is the sign of byochemical block of piruvate-deydrogenasy due to the Ca++ antagonist action of nifedipine. Nifedipine favorable action was explained by the increased %L in patients with low %L during recovery time, that is expression of a increased aerobic metabolism.
D000368:Aged; D000787:Angina Pectoris / Q000378:metabolism*; D002304:Cardiac Pacing, Artificial; D003327:Coronary Disease / Q000378:metabolism* / Q000628:therapy; D005260:Female; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D009543:Nifedipine / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*
D007773:Lactates; D011725:Pyridines; D009543:Nifedipine
Effetti della nifedipina sul metabolismo del lattato nella cardiopatia ischemica. Valutazione mediante atrial pacing.