A comparative trial of slow-release aminophylline, salbutamol and a half dose combination in the prevention of childhood asthma.
The effect of slow-release aminophylline, salbutamol and a half dose combination of both was compared in children with chronic asthma. Drugs were given over three consecutive 5-week periods during which patients recorded daily peak flow measurements and symptom scores. At the end of each treatment period pulmonary function tests were done. Sixteen of twenty-nine children completed the trial satisfactorily and their results have been used for analysis. The data show slow-release aminophylline and salbutamol to be equally effective and the half dose combination as effective as either drug alone. The results suggest there may be a therapeutic advantage in combining a beta 2 agonist with theophylline when high doses of either drug alone are not fully effective or when toxic effects occur.
D000293:Adolescent; D000420:Albuterol / Q000627:therapeutic use*; D000628:Aminophylline / Q000627:therapeutic use*; D001249:Asthma / Q000517:prevention & control*; D002648:Child; D003692:Delayed-Action Preparations; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male
D003692:Delayed-Action Preparations; D000628:Aminophylline; D000420:Albuterol