title: The effect of levodopa with carbidopa (Sinemet R) on the metabolic response to semistarvation.
abstract: It has been reported that levodopa will prevent the adaptive fall in the resting metabolic rate (RMR) on a weight-reducing diet. Whether levodopa has a central or peripheral effect on the RMR has been investigated by giving carbidopa, a peripheral dopa decorboxylase inhibitor with levodopa (as SinemetR) to four obese subjects on a low-energy diet. SinemetR failed to prevent the adaptive reduction in the RMR to energy restriction suggesting that levodopa maintains the RMR by a peripheral effect or effects.
mesh_terms: D000222:Adaptation, Physiological / Q000187:drug effects; D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D001481:Basal Metabolism / Q000187:drug effects*; D002230:Carbidopa / Q000494:pharmacology*; D004038:Diet, Reducing; D004338:Drug Combinations / Q000494:pharmacology; D002149:Energy Intake; D005260:Female; D006801:Humans; D007980:Levodopa / Q000494:pharmacology*; D008875:Middle Aged; D009765:Obesity / Q000628:therapy*; D014284:Triiodothyronine / Q000097:blood
chemical_list: D065105:Aromatic Amino Acid Decarboxylase Inhibitors; D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D014284:Triiodothyronine; D007980:Levodopa; D002230:Carbidopa