Role of the central nervous system in acute-phase responses to leukocytic pyrogen.
Intracerebroventricular injection of rabbit leukocytic pyrogen (LP) into conscious, healthy cannulated rabbits produced markedly enhanced febrile and acute-phase responses as compared with equivalent-dose, single bolus intravenous injection. The increased effectiveness in inducing granulocytosis and hypoferremia on intracerebroventricular injection was matched by changing the method of administration of intravenous LP from a single initial bolus to multiple fractional doses over a 2-h period. This suggested that augmentation for these parameters may have reflected only a "reservoir" function of the cerebral ventricles which prevented rapid clearance of LP from the blood. The ability of LP to induce hepatic synthesis of haptoglobin and C-reactive protein was so markedly enhanced by intracerebroventricular injection, however, that a role of the central nervous system in mediating or in modifying in an important way a non-neural mechanism for this mediation must be postulated.
D000818:Animals; D001921:Brain / Q000187:drug effects*; D002097:C-Reactive Protein / Q000096:biosynthesis*; D002552:Cerebral Ventricles; D004305:Dose-Response Relationship, Drug; D005334:Fever / Q000139:chemically induced; D006098:Granulocytes / Q000276:immunology; D006242:Haptoglobins / Q000096:biosynthesis*; D007501:Iron / Q000097:blood; D008099:Liver / Q000378:metabolism; D011749:Pyrogens / Q000494:pharmacology*; D011817:Rabbits
D006242:Haptoglobins; D011749:Pyrogens; D002097:C-Reactive Protein; D007501:Iron