Choline acetyltransferase for differentiation between human motor and sensory nerve fibers.
A rapid and precise nerve fascicle identification method based on the enzymatic activity of choline acetyltransferase (choline acetylase, or ChAC) is described. Motor nerve facicles demonstrated significantly higher ChAC activity in comparison to sensory nerve facicles. Based on this difference in activity, matching of nerve fascicle cut ends is possible in cases of recent trauma.
D000344:Afferent Pathways / Q000201:enzymology*; D002102:Cadaver; D002795:Choline O-Acetyltransferase / Q000032:analysis*; D006801:Humans; D008475:Median Nerve / Q000201:enzymology; D009046:Motor Neurons / Q000201:enzymology*; D059348:Peripheral Nerve Injuries; D010525:Peripheral Nerves / Q000201:enzymology / Q000601:surgery*; D011826:Radial Nerve / Q000201:enzymology; D012584:Sciatic Nerve / Q000201:enzymology
D002795:Choline O-Acetyltransferase