Renal function in rats with acute medullary injury.
Acute, reversible renal failure affecting primarily medullary structures, was produced by feeding rats a diet containing 5% oxonic acid and 2.5% uric acid for 7 days. Inulin clearance and selected tubular transport processes were studied and compared to controls. At the time of maximal renal injury, inulin clearance was reduced to 40% of control values, in association with a 60% reduction in urine concentrating ability, a 50% reduction in potassium excretion and a 56% reduction in ammonium excretion. During a 7-day recovery period, inulin clearance increased to 70% of control and potassium excretion returned to normal while the other tubular transport functions remained impaired. Thus, in acute renal failure, tubular functional impairments may recover at different rates.
D058186:Acute Kidney Injury / Q000209:etiology / Q000503:physiopathology*; D000818:Animals; D002118:Calcium / Q000652:urine; D004032:Diet; D004195:Disease Models, Animal; D005919:Glomerular Filtration Rate; D006863:Hydrogen-Ion Concentration; D007444:Inulin; D007679:Kidney Medulla / Q000503:physiopathology*; D007684:Kidney Tubules / Q000503:physiopathology*; D008297:Male; D010094:Oxonic Acid; D011188:Potassium / Q000652:urine; D051381:Rats; D014527:Uric Acid
D014527:Uric Acid; D010094:Oxonic Acid; D007444:Inulin; D011188:Potassium; D002118:Calcium