[Interaction between blood platelets and capillary kidney in haemodialysis (author's transl)].
In haemodialysis an interaction between platelets and the dialysator membrane occurs, which is not prevented by heparin. This can be demonstrated by parietal depositions of platelets in the capillaries of the artificial kidney by scanning electron microscopy, as well as in a marked increase of reversible platelet microaggregates during the first phase of dialysis. Some patients are prone to develop thrombosis of the capillary kidneys in spite of a high-dose heparinization. In these cases the use of diclofenac, a cyclooxygenase inhibitor, prevents these adverse platelet reactions.
D000293:Adolescent; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects*; D004008:Diclofenac / Q000494:pharmacology*; D005260:Female; D005921:Glomerulonephritis / Q000628:therapy; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008854:Microscopy, Electron; D008875:Middle Aged; D010648:Phenylacetates / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects; D011704:Pyelonephritis / Q000628:therapy; D006435:Renal Dialysis
D008567:Membranes, Artificial; D010648:Phenylacetates; D004008:Diclofenac; D006493:Heparin
Die Interaktion zwischen Thrombozyten und Kapillarniere im Rahmen der Hämodialyse.