title: Evaluation of the Sensititre system for quantitative antimicrobial drug susceptibility testing: a collaborative study.
abstract: This three-center collaborative study was conducted to evaluate samples of Sensititre antimicrobial microdilution panels (GIBCO/INVENEX). Sensititre minimum inhibitory concentrations of 27 bacterial isolates were compared with those obtained by a reference microdilution method. The Sensititre and microdilution minimum inhibitory concentrations were equivalent within +/- 1 dilution in 87.6% of the comparable test results. Intralaboratory reproducibilities of the Sensititre and microdilution endpoints were equivalent with 80.4 and 82.4%, respetively, of on-scale endpoints in absolute agreement. Sensititre was more reproducible among laboratories, with nearly a 10% greater agreement of triplicate results. The Sensititre microdilution test as evaluated gave results which were essentially equivalent to those obtained with a standardized microdilution method.
mesh_terms: D000617:Aminoglycosides / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects*; D006801:Humans; D007769:Lactams / Q000494:pharmacology; D008826:Microbial Sensitivity Tests / Q000379:methods*; D013045:Species Specificity
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D007769:Lactams