[Dynamics of central venous, arterial, and cerebrospinal fluid pressures following polyethyleneglycol administration].
The polyethylenglycol -- 400 (PEG) in dose 6 ml/kg at the rate of 0.2 ml/kg/min was i. v. administered to 12 anesthetized cats. The increase of osmolarity in the blood serum caused the hypervolemia, increase of arterial (by 20-30 mm Hg) and systemic venous (by 80-100 mm H2O) pressures, but in 30 min after the end of PEG infusion the hemodynamics returned to the initial levels due to increased diuresis, whereas the cistern CSF pressure decreased as a result of dehydration of the brain. This decrease was counteracted by the high venous and arterial pressures, but, after normalizing of hemodynamics the CSF pressure was decreased by 90-100 mm H2O as against initial level.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001923:Brain Chemistry / Q000187:drug effects; D002415:Cats; D002496:Central Venous Pressure / Q000187:drug effects*; D005260:Female; D007427:Intracranial Pressure / Q000187:drug effects*; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology*; D011674:Pulse; D012119:Respiration; D012964:Sodium / Q000032:analysis; D014867:Water / Q000032:analysis
D014867:Water; D011092:Polyethylene Glycols; D012964:Sodium
Dinamika tsentral'nogo venzonogo, arterial'nogo i likvornogo davleniia pri vvedenii poliétilenglikolia.