Vitamin A and corticosteroid interaction in wound healing in rats.
The possible antagonistic interaction of vitamin A and corticosteroids in wound healing was studied in several groups of rats. Follow-up showed that hydrocortisone did not delay wound healing, whereas a long-acting preparation of 6 alpha-methylprednisolone (DEPO-MEDROL) suppressed spontaneous healing of open wounds. Topical application of vitamin A caused a further delay in healing, whereas systemic use of vitamin A had no consistent effect. Since no beneficial effect of vitamin A could be demonstrated, and in view of its possible toxicity, we recommend that the clinical use of vitamin A in wound treatment be reconsidered.
D000284:Administration, Oral; D000287:Administration, Topical; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D006854:Hydrocortisone / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D014801:Vitamin A / Q000008:administration & dosage / Q000494:pharmacology*; D014945:Wound Healing / Q000187:drug effects*
D014801:Vitamin A; D006854:Hydrocortisone; D008775:Methylprednisolone