Effect of splanchnectomy and vagotomy on the pepsinogen response to intragastric acid.
Perfusion of the stomach in the anaesthetized rat with saline acidified to pH 2.5 with hydrochloric acid induced a small but significant release of pepsinogen into the perfusate. This stimulus to secretion was unaffected by splanchnectomy but was abolished by vagotomy. It is concluded that a modest degree acid secretion in the rat may stimulate pepsinogen secretion by a vagal pathway.
D000818:Animals; D005744:Gastric Acid / Q000502:physiology*; D006851:Hydrochloric Acid / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D008297:Male; D010435:Pepsinogens / Q000378:metabolism*; D051381:Rats; D013153:Splanchnic Nerves / Q000502:physiology*; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*
D010435:Pepsinogens; D006851:Hydrochloric Acid