Antibody suppression in mice infected with Nippostrongylus brasiliensis.
A/SN mice infected with N. Brasiliensis showed depressed anti-DNP antibody responses following immunization with DNP-Asc in alum. The immunosuppression was only observed when infection preceded immunization by between 2 and 7 days, and was not achieved when the interval was extended to 10 days. The suppression lasted at least 50 days, and affected IgE levels more than IgG1 or IgG agglutinating anti-DNP antibodies. A high dose of infective larvae (500-1000 per mouse) was necessary to induce suppression. Use of low dose irradiation indicated a parasite-induced radiosensitive component of the mouse immune system which negatively regulated the anti-DNP IgE response. These results suggested that the parasite could induce suppression in an analogous manner to sequential antigen-induced suppression (AIS).
D000818:Animals; D000917:Antibody Formation; D004140:Dinitrophenols / Q000276:immunology; D005260:Female; D007108:Immune Tolerance; D007114:Immunization; D007073:Immunoglobulin E / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009349:Nematode Infections / Q000276:immunology*; D009559:Nippostrongylus / Q000276:immunology*
D004140:Dinitrophenols; D007074:Immunoglobulin G; D007073:Immunoglobulin E