[Biochemical evaluation of the therapeutic effectiveness of coccidin in coccidiosis of hens].
20-day old chicks were infected with Eimeria tenella, treated with coccidin (250 mg/kg) and free amino acids of the femoral muscle tissues were studied. The infection of chicks was accompanied with metabolism disorders of all amino acids of the muscle tissue excluding leucine, methionine, tyrosine and phenylalanine. During the treatment of infected chicks with coccidin the level of free amino acids re-established within 10 days. This preparation affected most of all metabolism of alanine, isoleucine, aspartic acid and glycine and was less efficient in the re-establishment of the level araginine, lysine and threonine. It is suggested during the tests of coccidiostatics to take into consideration free amino acids of muscle tissues for the estimation of the efficiency of medical substances.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002645:Chickens; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D005260:Female; D005609:Free Radicals; D009132:Muscles / Q000378:metabolism; D011201:Poultry Diseases / Q000188:drug therapy* / Q000378:metabolism
D000596:Amino Acids; D003049:Coccidiostats; D005609:Free Radicals
Biokhimicheskaia otsenka lechebnoĭ éffektivnosti koktsidina pri koktsidioze kur.