title: Control of reabsorption of water and electrolytes by guinea-pig seminal vesicle in vivo.
abstract: Guinea-pig seminal vesicles reabsorbed Na+ and K+ in vivo from a standard bicarbonate buffer against both electrical and chemical gradients. Water was reabsorbed with the ions. Concentrations of Na+ and K+ in the reabsorbate were greater than in plasma or the initial buffer perfusate. Guinea-pigs castrated for 6 days did not reabsorb water or electrolytes, but daily administration of testosterone or 5 alpha-dihydrotestosterone restored normal reabsorption rates. Addition of prostaglandin E-2 to the perfusate inhibited water and Na+ reabsorption. Section of the hypogastric nerve did not affect reabsorption rates measured 10 days later. We suggest that the guinea-pig seminal vesicle maintains a basal reabsorptive capacity to remove electrolytes and water that diffuse or are secreted into the lumen and that the reabsorptive pump may be coupled to a secretory one activated intermittently and perhaps partly modulated by prostaglandins.
mesh_terms: D000042:Absorption; D000818:Animals; D002369:Castration; D003714:Denervation; D013196:Dihydrotestosterone / Q000494:pharmacology; D006168:Guinea Pigs; D008297:Male; D011188:Potassium / Q000378:metabolism*; D011458:Prostaglandins E / Q000494:pharmacology; D012669:Seminal Vesicles / Q000187:drug effects / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology; D014867:Water / Q000378:metabolism*
chemical_list: D011458:Prostaglandins E; D014867:Water; D013196:Dihydrotestosterone; D013739:Testosterone; D012964:Sodium; D011188:Potassium