Induction of zinc-thionein in rat liver and kidneys by zinc loading as studied at isometallothionein levels.
Zinc acetate was injected i.p. into female rats to try to clarify the detailed induction and degradation pathways of zinc-thionein (Zn-th) at isometallothionein levels in liver and kidneys. Injected zinc in serum decreased with the induction of Zn-th in the liver and kidneys, and the amounts of Zn-th in both tissues attained maxima 24 h after injection. The relative ratios of isometallothioneins changed with time in both tissues. The changes are compared with those of cadmium (Cd) loading.
D000818:Animals; D002104:Cadmium / Q000378:metabolism; D002850:Chromatography, Gel; D005260:Female; D007668:Kidney / Q000032:analysis / Q000378:metabolism*; D008099:Liver / Q000032:analysis / Q000378:metabolism*; D008667:Metalloproteins / Q000378:metabolism*; D008668:Metallothionein / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D015032:Zinc / Q000032:analysis / Q000378:metabolism*
D008667:Metalloproteins; D002104:Cadmium; D008668:Metallothionein; D015032:Zinc