Synthesis and pharmacological evaluation of some 2-N-alkyl-and -aralkyl-3,4:6,7-dibenzomorphans.
2-N-Alkyl or 2-aralkyl-5,9-dimethyl-3,4:6,7-dibenzomorphans 3a-c were synthesized by condensing 1-alkyl or aralkyl-3,4-dimethylquinolinium iodides 1a-c with benzyl magnesium chloride followed by subsequent cyclization of 2-benzyl-1-alkyl or aralkyl-3,4-dimethylquinolines 2a-c. Their structures were established through elemental and spectral studies. The preliminary pharmacological screening of 3a-c and other 3,4:6,7-dibenzomorphans [16] on mice showed that these compounds have a depressant action on CNS.
D000700:Analgesics; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001575:Benzomorphans / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects; D006591:Hexobarbital / Q000494:pharmacology; D007928:Lethal Dose 50; D051379:Mice; D009019:Morphinans / Q000138:chemical synthesis*; D009043:Motor Activity / Q000187:drug effects; D012890:Sleep / Q000187:drug effects
D000700:Analgesics; D001575:Benzomorphans; D009019:Morphinans; D006591:Hexobarbital