Presynaptic sympathetic supersensitivity following long-term preganglionic denervation.
After chronic preganglionic denervation of the rabbit ear artery, the contractile response to low frequency stimulation of the postganglionic innervation is increased. A preliminary analysis suggests that this cannot be accounted for by effector cell changes, but is due to an increase in adrenergic transmitter release.
D000320:Adrenergic Fibers / Q000502:physiology*; D000818:Animals; D001339:Autonomic Fibers, Preganglionic / Q000502:physiology*; D003714:Denervation; D004558:Electric Stimulation; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular; D009638:Norepinephrine / Q000494:pharmacology; D011817:Rabbits; D014439:Tyramine / Q000494:pharmacology
D009638:Norepinephrine; D014439:Tyramine