[The distribution of aminoglycoside antibiotics into the lymph and pancreatic fluid in dogs (author's transl)].
1. Serum, peripheral and thoracic lymph concentrations of tobramycin, dibekacin and amikacin were determined at various time intervals up to 6 hours following intramuscular administration of 4 mg/kg to dogs. Peak serum concentrations of each antibacterial agents occurred within one hour after administration. The peak lymphatic concentrations occurred in 1.5 approximately 2 hours after administration. Following peak peripheral lymph concentration, the concentration in peripheral lymph exceeded than that of serum. The concentrations of each antibacterial agent in thoracic lymph were nearly equal to serum concentration. Peak peripheral lymph concentrations were always lower than the peak serum concentrations. 2. Serum and pancreatic fluid concentrations of tobramycin, dibekacin and amikacin were determined at various time intervals up to 6 hours following intramuscular administration of 4 mg/kg to dogs. Peak pancreatic fluid concentrations of each antibacterial agents occurred within 1.5 hours after administration. The concentrations rate of tobramycin to the pancreatic fluid was superior to those of dibekacin and amikacin.
D000368:Aged; D000583:Amikacin / Q000097:blood / Q000378:metabolism*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000378:metabolism*; D003982:Dibekacin / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D005260:Female; D005839:Gentamicins / Q000097:blood; D006801:Humans; D007612:Kanamycin / Q000031:analogs & derivatives*; D008196:Lymph / Q000378:metabolism*; D008297:Male; D010189:Pancreatic Juice / Q000378:metabolism*; D014031:Tobramycin / Q000097:blood / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D003982:Dibekacin; D007612:Kanamycin; D000583:Amikacin; D014031:Tobramycin