Oscillations in plasma cortisol levels of newborns during exchange transfusion.
Plasma cortisol concentration was determined in blood samples obtained in six newborns during exchange transfusion at 3--5 minute intervals. A radiotransin-assay using horse serum as a binding protein and toluene-based scintillation fluid for separation of unbound tracer proved to be a relatively specific method for determination of cortisol level in the plasma of newborns. Irregular oscillations were observed in four newborns, whereas a single peak could be demonstrated in two cases during the 40--70 minute period observed. The results suggest that the CRF-ACTH-cortisol secretion may already be episodic in the newborn period.
D001327:Autoimmune Diseases / Q000097:blood* / Q000628:therapy; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000097:blood* / Q000628:therapy; D007567:Jaundice, Neonatal / Q000097:blood / Q000628:therapy*; D007700:Kinetics; D008297:Male
D006854:Hydrocortisone