Clinical efficacy of mild analgesics in pain following gynaecological or dental surgery: report on multicentre studies.
1 Dipyrone 1.0 g, paracetamol 1.0 g and placebo were compared in a double-blind parallel group study in patients with episiotomy pain. 2 Patients were stratified according to severity of initial pain (severe or moderate) and the three treatments were randomized for each of these two groups. 3 Two-hundred and sixty-four patients entered the study: five patients were excluded from analysis; 127 patients had 'severe' pain, 132 'moderate' pain. 4 Both drugs were more effective than placebo, and dipyrone was significantly more effective than paracetamol, particularly where initial pain was severe. 5 The efficacy of dipyrone 1.0 g was compared with paracetamol 1.0 g in relieving pain after tooth extraction. 6 Ninety patients entered the study and 87 were analyzed without stratification according to initial pain severity. 7 Dipyrone was consistently and significantly more effective than paracetamol at every assessment.
D000082:Acetaminophen / Q000627:therapeutic use; D000328:Adult; D000700:Analgesics / Q000627:therapeutic use*; D004177:Dipyrone / Q000627:therapeutic use; D004841:Episiotomy; D005260:Female; D006801:Humans; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000601:surgery
D000700:Analgesics; D000082:Acetaminophen; D004177:Dipyrone