title: [Investigations of combined injuries, 28th communication: Troubles of hemostatic equilibrium arising from radiation and combined injuries (author's transl)].
abstract: In female mice the influence of total-body irradiation combined with excision of skin on the blood-clotting system was examined. Whereas the general tests of plasmatic coagulation showed no significant change, a biphasic course of coagulation disturbances in thrombelastography and euglobulin-clot-lysis following combined radiation injury was found. During the first time a pronounced increase of coagulability appeared, followed by the development of a hypocoagulability due to thrombocytopenia and functional disturbances of blood platelets. In this hemorrhagic period the euglobulin-clotlysis time was accelerated, but only after combined injury. Possible reasons are discussed.
mesh_terms: D000818:Animals; D019567:Back Injuries; D001777:Blood Coagulation; D001780:Blood Coagulation Tests; D005260:Female; D006474:Hemorrhagic Disorders / Q000209:etiology; D051379:Mice; D011832:Radiation Injuries / Q000097:blood* / Q000150:complications; D013916:Thrombelastography; D014947:Wounds and Injuries / Q000097:blood* / Q000150:complications
vernacular_title: Untersuchungen über Kombinationsschäden. 28. Mittelung. Störungen im Hämostasesystem bei Strahlen- und Kombinationsschäden.