[Control of trace elements in the rat using the heavy metal antidote "Unithiol" (sodium-2,3- dimercaptopropane sulfonate)].
The trace element balance in laboratory rats was found to be affected by somewhat lasting application of "Unitiol". Unambiguous decline of manganese, copper, and zinc concentrations was recorded from blood and liver. Complex fixation of copper was stronger than that of the other elements tested. No dose-dependent changes were observed with the experimental arrangement described. The chromium levels in all examined organs were affected but slightly or not at all. The proposal is made that long-term therapeutic use of chelate formers should be accompanied by properly balanced application of essential trace elements.
D000818:Animals; D002857:Chromium / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D004112:Dimercaprol / Q000031:analogs & derivatives*; D005260:Female; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008345:Manganese / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009928:Organ Specificity; D051381:Rats; D014131:Trace Elements / Q000097:blood / Q000378:metabolism*; D014494:Unithiol / Q000494:pharmacology*; D015032:Zinc / Q000378:metabolism
D014131:Trace Elements; D004112:Dimercaprol; D002857:Chromium; D014494:Unithiol; D008345:Manganese; D003300:Copper; D015032:Zinc
Beeinflussung des Spurenelementhaushaltes der Ratte durch das Schwermetallantidot "Unitiol" (Natrium-2,3-dimercaptopropansulfonat).