Acromegaly associated with transient overproduction of growth hormone in a dog.
A 6-year-old female crossbred Belgian Shepherd Dog with features of acromegaly was monitored for almost 4 years. The history of frequent and excessive administration of a progestational agent suggested that the progestational drug induced the acromegaly. During the monitoring period. soft tissue changes diminished and there was normalization of several factors: plasma growth hormone concentration, response of plasma insulin and glucose to an oral glucose load, and response of plasma glucose hormone to the injection of insulin.
D000172:Acromegaly / Q000097:blood / Q000139:chemically induced / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000097:blood / Q000139:chemically induced*; D004285:Dogs; D005260:Female; D013006:Growth Hormone / Q000096:biosynthesis*; D008525:Medroxyprogesterone / Q000009:adverse effects
D013006:Growth Hormone; D008525:Medroxyprogesterone