Expression of the teratocarcinoma phenotype in hybrids between totipotent mouse teratocarcinoma and myeloma cells.
We have produced somatic cell hybrids between totipotent mouse teratocarcinoma and myeloma cells. These hybrids behave like the teratocarcinoma cell parent and express teratocarcinoma embryonal antigens. However, they also express the myeloma H-2 antigens. THe availability of these hybrids should make it possible to study the expression of already rearranged immunoglobulin genes during mouse development.
D000818:Animals; D000954:Antigens, Surface; D002460:Cell Line; D006183:H-2 Antigens / Q000032:analysis; D006822:Hybrid Cells / Q000276:immunology / Q000502:physiology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D051379:Mice; D009101:Multiple Myeloma / Q000276:immunology; D009368:Neoplasm Transplantation; D010641:Phenotype; D013724:Teratoma / Q000209:etiology / Q000276:immunology; D014184:Transplantation, Homologous
D000954:Antigens, Surface; D006183:H-2 Antigens; D007074:Immunoglobulin G