Urinary tritium excretion following intravenous 3H-norepinephrine administration in hypertensive rats.
Spontaneously hypertensive rats (SHR), salt-resistant (SRR), salt-sensitive (SSR), and Sprague-Dawley DOC-salt nephrectomized rats were tested by evaluation of tritiated norepinephrine uptake and blood pressure with diets containing various amounts of sodium. Only Sprague-Dawley rats who had been both nephrectomized and given DOC on a high salt diet (8%) illustrated the elevated tritium excretion similar to that observed in human subjects with essential hypertension.
D000818:Animals; D001794:Blood Pressure; D003900:Desoxycorticosterone / Q000008:administration & dosage; D004039:Diet, Sodium-Restricted; D006973:Hypertension / Q000503:physiopathology*; D007275:Injections, Intravenous; D007553:Isotope Labeling; D008297:Male; D009392:Nephrectomy; D009638:Norepinephrine / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology*; D051381:Rats; D012965:Sodium Chloride / Q000008:administration & dosage; D014316:Tritium / Q000652:urine*
D014316:Tritium; D003900:Desoxycorticosterone; D012965:Sodium Chloride; D009638:Norepinephrine