title: Mechanisms of beat-to-beat variability in the heart rate of the neonatal lamb. I. Influence of the autonomic nervous system.
abstract: The contributions of the intrinsic, beta-adrenergic, and cholinergic systems to the mechanisms of beat-to-beat variability of the heart rate were investigated in chronically instrumented, unanesthetized newborn lambs from the first week to the eighth week of neonatal life. During this period of neonatal growth, the resting heart rate decreased spontaneously every week; the decrease was not related to alterations in the sympathetic and parasympathetic tones but rather to changes in the intrinsic mechanisms of heart rate control. Despite the weekly decrease in the resting heart rate of the neonatal lamb, the long and short-term beat-to-beat variabilities did not change significantly. This finding suggests an absence of a significant influence of the intrinsic mechanisms of heart rate control on the genesis of beat-to-beat variability. The results obtained with the various modes of adrenergic and cholinergic blockades and stimulation seem to indicate that the autonomic nervous system contributes significantly to the appearance of beat-to-beat variability. However, the influences of the adrenergic and cholinergic systems differ from week to week of neonatal growth and the patterns of changes are not the same for the long-term and short-term variabilities. The implication of these studies in terms of physiologic and hemodynamic significance of beat-to-beat variability in heart rate is discussed.
mesh_terms: D000375:Aging; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001337:Autonomic Agents / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000187:drug effects / Q000502:physiology*; D006339:Heart Rate; D012756:Sheep / Q000254:growth & development / Q000502:physiology*
chemical_list: D001337:Autonomic Agents