[Action of remantadine on virus-specific polypeptide synthesis in a Sindbis virus-infected cell culture].
Effect of remantadine (alpha-methyl-I-adamantane methylamine) on reproduction and synthesis of the virus-specific polypeptides was studied in culture of chicken embryo fibroblasts, infected with virus Syndbis. The preparation inhibited the virus reproduction as well as the formation of virus-specific proteins after addition into the cultural medium together with virus, immediately after absorption and within 1 and 2 hrs after absorption. The data obtained suggest a possibility of an immediate effect of remantadine on the synthesis of virus-specific macromolecules.
D000042:Absorption; D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D002642:Chick Embryo; D010452:Peptide Biosynthesis; D012299:Rimantadine / Q000494:pharmacology*; D012845:Sindbis Virus / Q000187:drug effects*; D013997:Time Factors; D014764:Viral Proteins / Q000096:biosynthesis; D014776:Virus Cultivation; D014779:Virus Replication / Q000187:drug effects
D014764:Viral Proteins; D012299:Rimantadine; D000218:Adamantane
Deĭstvie remantadina na sintez virusspetsificheskikh polipeptidov v kul'ture kletok, infitsirovannykh virusom Sindbis.