Morphologic and histochemical evidence for the occurrence of collagenolysis and for the role of neutrophilic polymorphonuclear leukocytes during cervical dilation.
Biopsy specimens of nonpregnant and intrapartum human cervices were studied by electron microscopy, and by the Picrosirius-polarization method which is a specific procedure for the detection of collagen fibers in tissue sections. The results obtained demonstrate a marked reduction of collagen fibers in the intrapartum material as compared to the samples of nonpregnant cervices. Evidence that indicated the presence of a widespread collagenolysis in the intrapartum biopsy specimens was obtained by both optical and electron microscopy, thus suggesting that this might be the main cause of the changes in the cervix that permit it to dilate during parturition. The study of the neutrophilic polymorphonuclear leukocytes in the intrapartum biopsy specimens strongly suggested that these cells participate in this process.
D002584:Cervix Uteri / Q000166:cytology* / Q000502:physiology; D003094:Collagen / Q000032:analysis; D003238:Connective Tissue / Q000032:analysis; D003239:Connective Tissue Cells; D005260:Female; D006025:Glycosaminoglycans / Q000032:analysis; D006801:Humans; D007743:Labor, Obstetric; D009504:Neutrophils / Q000166:cytology* / Q000502:physiology; D011247:Pregnancy
D006025:Glycosaminoglycans; D003094:Collagen