title: [Histopathological studies of the rat pancreas after prolonged treatment with imuran. Preliminary findings].
abstract: The AA. have studied the pathological effects on the pancreas of rats after chronic administration of azathioprine (AZA) in different doses. The most significant lesions are flattening of duct epitelium and the presence of protein plugs in the ducts. These pancreatic lesions are significantly more frequent in rate treated with higher doses than in controls and so are dose-dependent.
mesh_terms: D000818:Animals; D001379:Azathioprine / Q000008:administration & dosage / Q000009:adverse effects*; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D010179:Pancreas / Q000473:pathology; D010182:Pancreatic Diseases / Q000139:chemically induced*; D051381:Rats
chemical_list: D001379:Azathioprine
vernacular_title: Osservazioni istopatologiche in pancreas di ratti dopo trattamento protratto con imuran. Rilievi preliminari.