Mepirizole, a non-steroidal antiinflammatory compound, its ulcerogenicity and inhibitory action on lesions induced by acidic antiinflammatory agents in the rat stomach.
Gastric lesions were produced in rats by the administration for 2 weeks of 300 mg/kg/day of mepirizole, a basic non-steroidal antiinflammatory compound. Although the single administration of 200 mg/kg of mepirizole had no effect, the addition of water-immersion stress for one hour induced lesions not only in the corpus but also in the pyloric antrum. The administration of 250 mg/kg of mefenamic acid, an acidic non-steroidal antiinflammatory compound (insufficient for producing gastric lesions at this dose alone) with the addition of one hour of water-immersion stress induced gastric lesions. The addition of 200 mg/kg of mepirizole reduced the ulcer index from 8.1 to 4.7 in the corpus and from 4 to 0.5 in the pyloric antrum. It is suggested that basic antiinflammatory compounds inhibit gastric lesions induced by combination of acidic antiinflammatory compounds and water-immersion stress.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004840:Epirizole / Q000008:administration & dosage; D005342:Fibrinolysis; D005753:Gastric Mucosa / Q000502:physiology; D008297:Male; D008528:Mefenamic Acid / Q000008:administration & dosage* / Q000037:antagonists & inhibitors; D011720:Pyrazoles / Q000008:administration & dosage; D051381:Rats; D013276:Stomach Ulcer / Q000139:chemically induced*; D013312:Stress, Physiological / Q000150:complications*
D000893:Anti-Inflammatory Agents; D011720:Pyrazoles; D008528:Mefenamic Acid; D004840:Epirizole