Effect of treatment of hyperlipidaemia on haemostatic variables.
The haemostatic function of 11 men with hyperlipidaemia was measured before and after they were treated with a carbohydrate-reduced, fat-modified diet. After treatment, which significantly reduced serum triglyceride and cholesterol concentrations, they showed a significant fall in mean levels of clotting factors VII, VIII, and X and a rise in fibrinolytic activity. These findings suggest that haemostatic function may be important in the pathogenesis of ischaemic heart disease.
D000328:Adult; D000368:Aged; D001779:Blood Coagulation Factors / Q000032:analysis*; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000097:blood; D004040:Dietary Carbohydrates / Q000008:administration & dosage; D005342:Fibrinolysis; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000178:diet therapy*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D001779:Blood Coagulation Factors; D001786:Blood Glucose; D004040:Dietary Carbohydrates; D014280:Triglycerides; D002784:Cholesterol