Antitumor activity of 7-N-phenyl derivatives of mitomycin C in the leukemia P388 system.
The antitumor activity of 7-N-phenyl derivatives of mitomycin C was tested in an ip-ip system of mouse leukemia P388 by single administration. The compounds tested were 7-N-phenyl-, 7-N-(p-aminophenyl)-, 7-N-(p-hydroxyphenyl)- and 7-N-(p-chlorophenyl)-mitomycin C. The maximum increases in life span (ILSmax) obtained were 124, 169, > 386 and 112%, respectively, that with mitomycin C being 104%. 7-N-(p-Hydroxyphenyl)-mitomycin C showed a higher ILS% than its ortho and meta isomers. Thus, 7-N-(p-hydroxyphenyl)-mitomycin C was the most effective of these compounds.
D000818:Animals; D007941:Leukemia P388 / Q000188:drug therapy*; D007942:Leukemia, Experimental / Q000188:drug therapy*; D051379:Mice; D016685:Mitomycin; D008937:Mitomycins / Q000031:analogs & derivatives* / Q000627:therapeutic use; D013329:Structure-Activity Relationship
D008937:Mitomycins; D016685:Mitomycin; C027281:7-N-(4-hydroxyphenyl)mitomycin C