title: Induction of zinc-thionein in rat liver and kidneys by zinc loading as studied at isometallothionein levels.
abstract: Zinc acetate was injected i.p. into female rats to try to clarify the detailed induction and degradation pathways of zinc-thionein (Zn-th) at isometallothionein levels in liver and kidneys. Injected zinc in serum decreased with the induction of Zn-th in the liver and kidneys, and the amounts of Zn-th in both tissues attained maxima 24 h after injection. The relative ratios of isometallothioneins changed with time in both tissues. The changes are compared with those of cadmium (Cd) loading.
mesh_terms: D000818:Animals; D002104:Cadmium / Q000378:metabolism; D002850:Chromatography, Gel; D005260:Female; D007668:Kidney / Q000032:analysis / Q000378:metabolism*; D008099:Liver / Q000032:analysis / Q000378:metabolism*; D008667:Metalloproteins / Q000378:metabolism*; D008668:Metallothionein / Q000032:analysis / Q000378:metabolism*; D051381:Rats; D013054:Spectrophotometry, Atomic; D013997:Time Factors; D015032:Zinc / Q000032:analysis / Q000378:metabolism*
chemical_list: D008667:Metalloproteins; D002104:Cadmium; D008668:Metallothionein; D015032:Zinc