Effects of danazol and lynestrenol on serum lipoproteins in endometriosis.
The treatment of endometriosis with danazol or lynestrenol decreased cholesterol content of plasma high-density lipoproteins by 50% and 32%. There were simultaneous increases in low-density lipoprotein cholesterol content of 51% and 19%. We suggest that changes induced by lynestrenol are due to progestational activity, while in the case of danazol both antigonadotropic and androgenic activities are involved.
D000328:Adult; D003613:Danazol / Q000494:pharmacology*; D004715:Endometriosis / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008234:Lynestrenol / Q000494:pharmacology*; D011245:Pregnadienes / Q000494:pharmacology*
D008074:Lipoproteins; D011245:Pregnadienes; D003613:Danazol; D008234:Lynestrenol