Interrelationships of lipids, lipoproteins, and clinical chemistry measurements in 1605 schoolchildren, ages 6-17: the Princeton Schoolchildren Study.
Interrelationships between clinical chemistry tests (hepatic, renal, and endocrine systems) and lipids-lipoproteins were assessed in 1605 schoolchildren ages 6-17; 916 were randomly selected and 689 selected because of hypercholesterolemia/hypertriglyceridemia from the Cincinnati Lipid Research Clinic's Princeton School study. The clinical chemistry measurements most consistently and uniformly rated to lipids and lipoproteins were plasma glucose (GLU), uric acid (UA), serum glutamic oxaloacetic transaminase (SGOT) and hematocrit (HEMO). These relationships were similar quantitatively and qualitatively in 6-11-yr-old and 12-17-yr-old children in both the random and the hyperlipidemic recall groups. The most consistent relationship was a positive one between glucose and triglyceride (TG) and very low density lipoprotein cholesterol (C-VLDL). A second, highly consistent, relationship pattern included an inverse correlation between serum UA and high density lipoprotein cholesterol (C-HDL)), and a positive UA-C-VLDL relationship; both were seen in 12-17-yr-old children. Hematocrit was positively associated with TG; SGOT was positively associated with total cholesterol and C-HDL. Many of these relationships, particularly those for plasma GLU and UA, presage relationships observed in normal and hyperlipoproteinemic adults, and may allow a better understanding of the physiology and pathophysiology of lipid and lipoprotein levels.
D000293:Adolescent; D000367:Age Factors; D001219:Aspartate Aminotransferases / Q000097:blood; D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002784:Cholesterol / Q000097:blood; D005260:Female; D006400:Hematocrit; D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008079:Lipoproteins, VLDL / Q000097:blood; D008297:Male; D014280:Triglycerides / Q000097:blood; D014527:Uric Acid / Q000097:blood
D001786:Blood Glucose; D008055:Lipids; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D014527:Uric Acid; D002784:Cholesterol; D001219:Aspartate Aminotransferases