Clinical and immunological features of transient IgA deficiency in children.
Of eighteen children, in whom no IgA was detected in serum or whole saliva, twelve remained IgA-deficient, but six developed normal IgA levels between the age of 5 and 13 years. In the former, allergic asthma, elevated serum IgM and IgE levels, a high number of IgE-bearing and -containing peripheral lymphocytes, and rather low numbers of circulating T cells and PHA responses were common. Conversely, most of the latter suffered from respiratory tract infections, had normal T and B cell assays, serum IgM and IgE and no asthma. When serum and saliva IgA increased, their recurrent respiratory tract infections ceased.
D000293:Adolescent; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D004406:Dysgammaglobulinemia / Q000150:complications / Q000276:immunology*; D005260:Female; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000276:immunology; D017098:IgA Deficiency; D007136:Immunoglobulins / Q000032:analysis; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D012141:Respiratory Tract Infections / Q000209:etiology / Q000276:immunology; D012463:Saliva / Q000276:immunology
D007136:Immunoglobulins