Induction of extra-thymic lymphatic leukemias in nude mice by means of administration of N-methyl-N-nitrosourea (MNU).
Experiments concerning the chemical leukemogenesis in nude mice were performed. Following administration of N-methyl-N-nitrosourea (MNU) 4 out of 11 nude mice developed extra-thymic lymphatic leukemias. The findings are demonstrated by means of histological and histochemical methods. The successful cellular transplantation of an induced lymphatic leukemia is reported.
D000818:Animals; D005260:Female; D007942:Leukemia, Experimental / Q000139:chemically induced*; D007945:Leukemia, Lymphoid / Q000139:chemically induced*; D008099:Liver / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008297:Male; D008770:Methylnitrosourea / Q000494:pharmacology*; D051379:Mice; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D013154:Spleen / Q000473:pathology; D014184:Transplantation, Homologous
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea