Effects of melatonin and propranolol on sleep of the rat.
Melatonin and L-propranolol, which inhibits melatonin synthesis, were administered to rats at 07.45 h and 19.45 h. Melatonin given in the morning decreased non-REM sleep, but when given at night had no effect on sleep stages. L-propranolol given in the morning had no effect on non-REM sleep, but increased it at night. L-propranolol produced decreased in percentage REM sleep at both times.
D000818:Animals; D002940:Circadian Rhythm / Q000187:drug effects; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D012894:Sleep Stages / Q000187:drug effects*; D012895:Sleep, REM / Q000187:drug effects
D011433:Propranolol; D008550:Melatonin