Polymorphonuclear function in patients with skin and joint symptoms after small-intestinal shunt operations.
Previous studies have shown that the small-bowel shunt operation for morbid obesity may be followed by signs of enhanced cell-mediated immunity and polymorphonuclear (PMN) granulocyte bactericidal capacity. In the present study seven patients, operated 4 months--4.5 years previously and exhibiting postoperative arthralgias, arthritis, and/or skin rashes, were investigated with regard to their PMN adherence and bactericidal capacity and plasma levels of complement factors 3 and 4 (C3 and C4). There patients showed a decreased PMN bactericidal capacity compared both with 10 other shunt-operated patients without skin and joint symptoms and with healthy controls, whereas PMN adherence was lower than for the non-symptomatic patients but similar to that of the controls. Two patients had C3 levels above the reference value; all had normal C4 values. Thus, a small-bowel shunt operation for obesity, complicated by skin and joint symptoms, might be associated with decreased PMN bactericidal capacity.
D000328:Adult; D001168:Arthritis / Q000276:immunology*; D001770:Blood Bactericidal Activity; D002448:Cell Adhesion; D003176:Complement C3 / Q000032:analysis; D003181:Complement C4 / Q000032:analysis; D005076:Exanthema / Q000276:immunology*; D005260:Female; D006801:Humans; D007111:Immunity, Cellular; D007421:Intestine, Small / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009437:Neuralgia / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D009765:Obesity / Q000628:therapy*; D011183:Postoperative Complications / Q000276:immunology*
D003176:Complement C3; D003181:Complement C4