title: Morphologic study on the interaction between the blood vessel wall and the blood flow: the arterial branching ostium and the site of permeability.
abstract: Regional permeability of the aortas (particularly branching portion) in the human and the rabbit was investigated. In the experiment for examining the permeability into the branching portion of the human aortas the permeability in a shape of an upside down triangle was found in the lower region of the ostia. The shape of this penetration highly resembled the shapes of the lesion of arteriosclerosis and lipid deposition. In the rabbit aortas the permeability of intravenously injected Evans blue occurred most strongly in the lower region of the opening of the intercostal arterial branch. The shape of the permeability was similar to that of the lipid deposition in the rabbit fed with 1% cholesterol. In the lower region of the branching portion of intercostal artery of the rabbit, the degenerative change of the endothelium was observed more frequently than in other regions. The feeding with 1% cholesterol was found to facilitate this degenerative change.
mesh_terms: D000818:Animals; D001011:Aorta / Q000033:anatomy & histology*; D001161:Arteriosclerosis / Q000503:physiopathology; D002199:Capillary Permeability; D002784:Cholesterol / Q000008:administration & dosage; D003326:Coronary Circulation; D004727:Endothelium / Q000648:ultrastructure; D005070:Evans Blue; D006801:Humans; D011817:Rabbits
chemical_list: D005070:Evans Blue; D002784:Cholesterol