Renal and intrarenal blood flow in patients with cirrhosis before and after portal-systemic shunt.
Portal hypertension has been considered a pathogenetic factor in the onset of renal haemodynamic alterations in patients with cirrhosis. This hypothesis is based on experimental evidence, whereas the clinical data are few and contradictory. Mean and cortical renal blood flows were studied in 16 patients with liver cirrhosis before and 20-40 days after a portal-systemic shunt performed by different techniques: nine patients had a non-selective shunt and seven a selective shunt (distal splenorenal according to Warren). Despite a decrease in portal pressure, mean and cortical renal blood flows did not change significantly after surgery, and there was no significant correlation between decrease in portal pressure and modification of renal blood flow. It is concluded that portal hypertension is not a pathogenetic factor in renal hypoperfusion in cirrhosis.
D000328:Adult; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology; D007668:Kidney / Q000098:blood supply*; D008103:Liver Cirrhosis / Q000150:complications / Q000503:physiopathology* / Q000601:surgery; D008875:Middle Aged; D011167:Portacaval Shunt, Surgical; D011184:Postoperative Period