[Effect of gamma-aminobutyric acid and gamma-hydroxybutyric acid on the rate of 14C-leucine incorporation into proteins of the gastric mucosa and hypothalamus].
In experimental peptic ulcer the rate of labeled 14C-leucine inclusion in gastric mucosa proteins was decreased. Gamma-aminobutyric acid (GABA) and gamma-oxybutyric acid (GOBA) potentiated the inclusion of amino acids in gastric tissue and hypothalamus proteins, promoted the increased intensity of the trophic processes and exhibited an antiulcerous effect. Studies on 14C-GABA distribution in different organs of rats showed that the largest amount of the acid was detected in the liver and stomach, with a comparatively less amount being found in the hypothalamus.
D000818:Animals; D000897:Anti-Ulcer Agents; D005753:Gastric Mucosa / Q000378:metabolism*; D006885:Hydroxybutyrates / Q000494:pharmacology* / Q000627:therapeutic use; D007031:Hypothalamus / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D014176:Protein Biosynthesis; D051381:Rats; D013276:Stomach Ulcer / Q000188:drug therapy / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology* / Q000627:therapeutic use
D000897:Anti-Ulcer Agents; D006885:Hydroxybutyrates; D009419:Nerve Tissue Proteins; D005680:gamma-Aminobutyric Acid; D007930:Leucine
Vliianei gamma-aminomaslianoĭ i gamma-oksimaslianoĭ kislot na skorost' vkliucheniia 14C-leĭtsina v belki slizistoĭ obolochki zheludka i gipotalamusa.