Xenobiotic triglyceride formation.
1. When 3-phenoxy[14C]benzoic acid was dosed orally (0.76 mg/kg) to rats, 1--3% of the administered radioactivity was found in the skin four days after dosing. Approximately 90% of this residue was unchanged 3-phenoxybenzoate, 10% was a neutral compound. 2. The residue in the skins of rats dosed with 193 mg of 3-phenoxybenzoic acid over 7 days (c. 100 mg/kg per day) contained 40% 3-phenoxybenzoate and 60% neutral metabolites. 3. The components were separated and purified by gel permeation, absorption and t.l.c. and analysed by mass spectrometry. 4. 2- and 3-(3-Phenoxybenzoyl)dipalmitins were major components of the neutral metabolite.
D000818:Animals; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D005260:Female; D006863:Hydrogen-Ion Concentration; D008297:Male; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D012867:Skin / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D014280:Triglycerides