title: Retinal tumor induced in the baboon by human adenovirus 12.
abstract: Three of 21 newborn baboons injected intraocularly with human adenovirus type 12 developed an intravitreal mass 12 to 36 months later. Two of the masses were indistinguishable from human retinoblastoma, a retinal tumor that afflicts children. To our knowledge this is the first time a retinoblastoma-like tumor has been induced experimentally by adenovirus type 12 in a nonhuman primate.
mesh_terms: D000260:Adenoviruses, Human; D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000473:pathology; D002472:Cell Transformation, Viral; D004195:Disease Models, Animal; D005134:Eye Neoplasms / Q000382:microbiology*; D009374:Neoplasms, Experimental / Q000382:microbiology; D010215:Papio; D012175:Retinoblastoma / Q000382:microbiology* / Q000473:pathology