The in vitro effect of neurotensin on human jejunal mast cells.
Neurotensin was added to human jejunal mucosal biopsy specimens from six individuals. Fifty-seven per cent degranulation of mast cells was seen at a concentration of neurotensin of 10(-9) M and 43% at 10(-6) M, as compared with 31% with IgE antibody/antigen. There was no change in degranulation with neurotensin when IgE was added to biopsy specimens before neurotensin in a 10(-6) M solution. This effect of neurotensin on human jejunal mast cells supports the evidence for receptors for neurotensin on mast cells shown in rat experiments.
D003594:Cytoplasmic Granules / Q000187:drug effects; D006801:Humans; D007114:Immunization; D007073:Immunoglobulin E / Q000008:administration & dosage; D007413:Intestinal Mucosa / Q000187:drug effects; D007583:Jejunum / Q000166:cytology / Q000187:drug effects*; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D009496:Neurotensin / Q000008:administration & dosage / Q000494:pharmacology*
D007073:Immunoglobulin E; D009496:Neurotensin