A comparative study between Fc receptor bearing cells and antibody dependent cell cytotoxicity in cancer patients.
The capacity of 14 cancer patients lymphoid cells to destroy antibody-coated target cells (antibody-dependent cell cytotoxicity ADCC), and to form rosettes with immunoglobulin-coated erythrocytes (EA) was compared. The lymphocyte functions were investigated immediately prior to chemo-immunotherapy. Our observations show a correlation between the percentage of EA-rosette forming cells and ADCC activity of cancer patients and controls. However, the regressive lines were different in both groups. Interestingly, cancer patients with a lower. EA rosette forming cells than controls, showed higher cytotoxic activity.
D000328:Adult; D000368:Aged; D000920:Antibody-Dependent Cell Cytotoxicity; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D008875:Middle Aged; D009369:Neoplasms / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology*; D012397:Rosette Formation
D011961:Receptors, Fc