Decreased alanine aminotransferase activity in serum of man during gamma-acetylenic-GABA treatment.
Decreasing concentrations of alanine aminotransferase were observed in nine patients receiving gamma-acetylenic-GABA, an inhibitor of GABA aminotransferase. In vitro studies showed that preincubation at 37 degrees C of serum with gamma-acetylenic-GABA and with urine from a patient receiving the drug led to inhibition of alanine aminotransferase. This inhibition of alanine aminotransferase by gamma-acetylenic-GABA was neutralized by 1-analine, the natural substrate for the enzyme. The mechanism of inhibition may be a competition between the drug and 1-alanine for the substrate binding site of the enzyme.
D000612:4-Aminobutyrate Transaminase / Q000037:antagonists & inhibitors; D000410:Alanine Transaminase / Q000037:antagonists & inhibitors / Q000097:blood*; D000480:Alkynes; D000614:Aminocaproates / Q000494:pharmacology*; D006801:Humans
D000480:Alkynes; D000614:Aminocaproates; C013785:4-amino-5-hexynoic acid; D000612:4-Aminobutyrate Transaminase; D000410:Alanine Transaminase