Induction of nuclear androgen-binding sites in epithelium of the embryonic urinary bladder by mesenchyme of the urogenital sinus of embryonic mice.
Mesenchyme of the embryonic urogenital sinus induces epithelium of the embryonic urinary bladder to form prostatic acini. The induced glandular epithelium exhibits nuclear androgen-binding sites, as demonstrated autoradiographically. This suggests that the expression of androgen receptor activity in an epithelium is dependent upon the mesenchyme with which it is associated during development.
D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism*; D013196:Dihydrotestosterone / Q000378:metabolism; D004622:Embryo, Mammalian / Q000502:physiology; D004848:Epithelium / Q000378:metabolism; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011247:Pregnancy; D011467:Prostate / Q000196:embryology; D011944:Receptors, Androgen / Q000378:metabolism*; D011987:Receptors, Steroid / Q000378:metabolism*; D014184:Transplantation, Homologous; D001743:Urinary Bladder / Q000378:metabolism*; D014566:Urogenital System / Q000196:embryology / Q000637:transplantation*
D011944:Receptors, Androgen; D011987:Receptors, Steroid; D013196:Dihydrotestosterone