Cerium nitrate-silver sulfadiazine cream in the treatment of burns: a prospective evaluation.
In a prospective, randomized study of patients with major burns, the efficacy of cerium nitrate-silver sulfadiazine cream was compared with that of silver sulfadiazine cream alone. Sixty patients were studied, in two groups, with matching mean ages and mean burns sizes. Patients with associated injuries, smoke inhalation, or major medical illnesses were excluded from the study. The total number of deaths and the total number of deaths from sepsis were equal in both groups. The total number of patients whose quantitative burns wound biopsies indicated light (10(2) to 10(5) organisms/gm) or heavy (over 10(5) organisms/gm) colonization by microorganisms was not statistically different between the two groups. The distribution of bacterial isolates by organism was similar in both groups. In vitro sensitivity determinations indicated a comparable efficacy between the two agents. In this study no clear-cut superiority of one topical agent over the other could be demonstrated.
D000328:Adult; D001424:Bacterial Infections / Q000150:complications; D002056:Burns / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D002563:Cerium / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D008875:Middle Aged; D009566:Nitrates / Q000627:therapeutic use; D009824:Ointments; D012837:Silver Sulfadiazine / Q000627:therapeutic use*; D013411:Sulfadiazine / Q000627:therapeutic use*
D004338:Drug Combinations; D009566:Nitrates; D009824:Ointments; D013411:Sulfadiazine; D002563:Cerium; D012837:Silver Sulfadiazine