Pressure-regulating effects of prostaglandin E2, F2 alpha and cholecystokinin on canine choledochal and pancreatic ducts in vivo.
Changes in pressure in the choledochal and pancreatic ducts of dogs brought about by PGE2 and PGF2 alpha were studied in vivo. The stimulatory action of the c8-terminal cholecystokinin was inhibited by the prostaglandin synthesis inhibitor naproxen. PGF2 alpha increased the pressure, but PGE2 caused a decrease.
D000818:Animals; D002766:Cholecystokinin / Q000494:pharmacology*; D003135:Common Bile Duct / Q000187:drug effects* / Q000502:physiology; D004285:Dogs; D005260:Female; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D010183:Pancreatic Ducts / Q000187:drug effects* / Q000502:physiology; D011312:Pressure; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D011461:Prostaglandins F, Synthetic / Q000494:pharmacology*
D011459:Prostaglandins E, Synthetic; D011461:Prostaglandins F, Synthetic; D002766:Cholecystokinin