Delayed response to a alpha-hydroxycholecalciferol therapy in a case of hypoparathyroidism during anticonvulsant therapy.
A patient with idiopathic hypoparathyroidism and a six-year history of a convulsive disorder was treated with 1 alpha-hydroxycholecalciferol and anticonvulsants. The calcemic response to 1 alpha-hydroxycholecalciferol was incomplete. However, normocalcemia was later attained during treatment with dihydrotachysterol. This delayed response suggests that the anticonvulsant therapy interfered with the peripheral effect of the vitamin D metabolite.
D000293:Adolescent; D000927:Anticonvulsants / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D004097:Dihydrotachysterol / Q000627:therapeutic use; D004347:Drug Interactions; D005260:Female; D006801:Humans; D006887:Hydroxycholecalciferols / Q000627:therapeutic use*; D007011:Hypoparathyroidism / Q000188:drug therapy*; D010758:Phosphorus / Q000097:blood; D012640:Seizures / Q000188:drug therapy
D000927:Anticonvulsants; D006887:Hydroxycholecalciferols; D010758:Phosphorus; D004097:Dihydrotachysterol; D002118:Calcium; C008088:alfacalcidol