title: Effects of parenteral aminophylline on lung mechanics in normal human.
abstract: We studied the effects of an intravenous injection of 5.0 mg of aminophylline per kg of body weight on lung mechanics in 8 normal subjects. No change occurred in lung volumes, airway resistance, and maximal expiratory flow-volume and lung pressure-volume curves. Restudy of 4 of the subjects before and after an injection of 8.0 mg/kg of aminophylline did not modify the pattern of response to the drug, despite a serum concentration range of 15.1 to 19.3 mg/l. These findings were, therefore, in contrast with those observed after the administration of atropine or beta-2 adrenergic derivatives. They suggested that the bronchodilator effects of aminophylline may not be due to a direct action of the drug on the bronchial smooth muscle.
mesh_terms: D000328:Adult; D000628:Aminophylline / Q000008:administration & dosage / Q000494:pharmacology*; D001249:Asthma / Q000188:drug therapy; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008168:Lung / Q000187:drug effects* / Q000502:physiology; D008297:Male; D012129:Respiratory Function Tests
chemical_list: D000628:Aminophylline