title: Infected gangrene. A serious complication of peripheral vasopressin administration.
abstract: Vasopressin (Pitressin) infusion through peripheral veins is a commonly used modality for control of bleeding esophageal varices. In this report we describe the development of infected gangrene at the site of accidental vasopressin infiltration in a patient with diabetes mellitus, cirrhosis and bleeding esophageal varices. Among the explanations for the development of gangrene are: 1. continuous intravenous administration; 2. diabetic peripheral vascular disease; 3. mechanical compression of extravasated fluid in a closed space. No antagonist has been clinically proven to reverse the vasoconstrictive effects of vasopressin.
mesh_terms: D004932:Esophageal and Gastric Varices / Q000628:therapy; D005734:Gangrene; D006801:Humans; D007263:Infusions, Parenteral / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D014667:Vasopressins / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D014667:Vasopressins