The effect of season on the ovulatory response of Merino ewes to serum from pregnant mares.
Groups of 50 ewes were injected with serum from pregnant mares on 5 occasions, 3 months apart, and ovulation rate was estimated at laparoscopy. In Exp. 1, new ewes were used at each time and 3 dose rates (identical to 400, 630 and 1000 i.u. PMSG) were studied. In Exp. 2, the same ewes were used throughout and only 1 dose was given (1000 i.u.). In both experiments the response in ovulation rate of ewes varied significantly throughout the year, with the lowest response in spring (September) and the highest in autumn (March). The ewes in Exp. 2 were as responsive at the end as at the beginning of the experiment, indicating that the response was independent of the number of doses given. The results suggest that changes in the sensitivity of ovaries to gonadotrophin may be a factor controlling seasonal ovarian activity in sheep.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology*; D010060:Ovulation / Q000187:drug effects*; D012621:Seasons; D012756:Sheep / Q000502:physiology*
D006064:Gonadotropins, Equine