Use of a topical triple-antibiotic spray to reduce morbidity from pelvic infection after gynecologic operations.
To study the effect of a topical antibiotic spray in reducing postoperative morbidity when used during surgery, a randomized, double-blind study was done on 150 women who had a vaginal hysterectomy with or without colporrhaphy. The spray contained neomycin sulfate, polymyxin B sulfate and zinc bacitracin and was used in 75 patients; a placebo spray was used in the other 75 patients. The antibiotic spray significantly (P < 0.01) decreased the frequency of pelvic infections postoperatively--14.7% in the antibiotic group compared with 37.3% in the placebo group.
D000336:Aerosols; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage*; D001414:Bacitracin / Q000008:administration & dosage; D001424:Bacterial Infections / Q000517:prevention & control*; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007044:Hysterectomy; D009355:Neomycin / Q000008:administration & dosage; D010388:Pelvis; D010919:Placebos; D011112:Polymyxin B / Q000008:administration & dosage; D013530:Surgical Wound Infection / Q000517:prevention & control*
D000336:Aerosols; D000891:Anti-Infective Agents, Local; D004338:Drug Combinations; D010919:Placebos; D001414:Bacitracin; D009355:Neomycin; D011112:Polymyxin B