Cytolysis of fibroblasts by C3a.
C3a was found to be more cytolytic to transformed than to primary fibroblast cultures from mouse and man. Fibroblasts made quiescent with caffeine were lysed by the same concentrations of C3a as untreated cells. These findings may have implications in tumour immunity.
D000818:Animals; D002110:Caffeine / Q000494:pharmacology; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D002472:Cell Transformation, Viral; D002478:Cells, Cultured; D003176:Complement C3 / Q000276:immunology*; D005347:Fibroblasts / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D051379:Mice
D003176:Complement C3; D002110:Caffeine