title: Frequency and morphology of malignant tumours of the thyroid before and after the introduction of iodine-prophylaxis.
abstract: Reclassification of malignant goitres surgically removed between 1952-1975 reveals remarkable epidemiological alterations. There is a proportional decrease in undifferentiated carcinoma, which in males also represents an absolute decrease. The decrease is due to a change in maximum incidence from the 5th to the 7th decade. Differentiated carcinomas, especially the papillary tumours, increase. Comparison with findings in Switzerland shows many conformities. Iodine-prophylaxis apparently influences the morphology of thyroid carcinoma, as indicated by the time lag between the introduction of iodine-prophylaxis and the appearance of alterations in incidence. Iodine-prophylaxis, acting in this way, will improve survival rates in thyroid cancer.
mesh_terms: D000367:Age Factors; D001317:Austria; D002277:Carcinoma / Q000453:epidemiology; D005260:Female; D006042:Goiter / Q000517:prevention & control; D006801:Humans; D007455:Iodine / Q000627:therapeutic use*; D008297:Male; D012737:Sex Factors; D013557:Switzerland; D013964:Thyroid Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000601:surgery
chemical_list: D007455:Iodine