Adrenoleukodystrophy: white matter disease with adrenal changes in 33-year-old man.
Patients with changes such as those that occur in relatively diffuse disorders of higher nervous function constitute a major diagnostic problem. We are presenting a patient with dysphasia, incoordination, difficulty concentrating, and weight loss with underlying organic changes. This 33-year-old patient had adrenoleukodystrophy (ALD), which is a sex-linked recessive disorder involving the adrenal glands with central nervous system demyelination. ALD usually manifests itself during childhood.
D000307:Adrenal Gland Diseases / Q000175:diagnosis / Q000473:pathology*; D000328:Adult; D001927:Brain Diseases / Q000175:diagnosis / Q000473:pathology*; D003711:Demyelinating Diseases / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D008297:Male