title: Effect of isotonic volume expansion on glomerular filtration rate and renal hemodynamics in the developing rat kidney.
abstract: Young rats (20-24 days) and adult rats (40-45 days) were studied during hydropenia and volume expansion with regard to glomerular filtration rate (GFR) and the determinants of GFR. During hydropenia, GFR and renal blood flow (RBF) were significantly lower in younger than in adult rats both in absolute terms and when related to bodyweight. Equivalent degrees of volume expansion (6% of b.wt.) resulted in a much more pronounced increase in GFR and RBF in younger than in older rats. This suggests that the high renal vascular resistance in hydropenic young rats is primarily due to vasoconstriction. The relationship between the filtration rate of superficial nephrons and the total GFR was the same in hydropenic and volume expanded rats in both age groups. The tubular stop flow pressure, the calculated hydrostatic glomerular capillary pressure and ultrafiltration pressure in the afferent part of the glomerular capillaries was slightly lower in hydropenic young rats than in hydropenic adult rats. The pressures did not rise after volume expansion. It is concluded that the marked increase in GFR in volume expanded young rats is mainly due to increased renal plasma flow.
mesh_terms: D000818:Animals; D001794:Blood Pressure; D001798:Blood Proteins / Q000032:analysis; D001834:Body Water / Q000032:analysis; D005919:Glomerular Filtration Rate; D006400:Hematocrit; D006439:Hemodynamics; D006874:Hydrostatic Pressure; D007668:Kidney / Q000098:blood supply / Q000254:growth & development / Q000502:physiology*; D008297:Male; D051381:Rats; D012039:Regional Blood Flow; D014655:Vascular Resistance
chemical_list: D001798:Blood Proteins