[Anti-inflammatory activity of glycyrrhizic acid derivatives].
The derivatives of glycyrrhizin acid--dihydrazidohydrazose of glycyrrhizin acid (DHGA), DHGA plus benzaldehyde, DHGA plus 5-nitrofurfurol, DHGA plus furfurol, glycyrrhizin acid, methylmethioninsulfonium-glycyrrhizinate, sodium salt of 18-glycyrrhetic acid, and potassium salt of glycyrrhizin acid--show a pronounced anti-inflammatory action, inhibit the development of histamine-, serotonin-, bradykinin-, and formalin-induced edemas, barrier function of an inflammatory focus, lower vascular permeability, the granulemic sac weight and exudate amount. The anti-inflammatory action of the compounds remains unchanged under adrenalectomy. By antiphlogistic activity, the derivatives in question compare very favourably to butadion and hydrocortisone, and are similar to prednisolone.
D000315:Adrenalectomy; D000818:Animals; D000893:Anti-Inflammatory Agents; D002056:Burns / Q000188:drug therapy; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005534:Foot Diseases / Q000139:chemically induced / Q000188:drug therapy; D006034:Glycyrrhetinic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use / Q000633:toxicity; D019695:Glycyrrhizic Acid; D007928:Lethal Dose 50; D051379:Mice; D051381:Rats; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D019695:Glycyrrhizic Acid; D006034:Glycyrrhetinic Acid
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