Different dopaminergic mechanisms for amfonelic acid, amphetamine and apomorphine.
Rats were trained to discriminate between the stimulus properties of intraperitoneal 0.16 mg/kg apomorphine and saline in a two-lever, food-motivated operant task. Employing the selected lever and the extended schedule performance measurements to indicate the generalization effect and perseverance of that effect, respectively, neither d-amphetamine nor amfonelic acid produced apomorphine-like discriminative properties. In contrast, administration of 0.1 or 0.2 mg/kg n-propylnoraporphine was observed to produce responses and perseverance on the apomorphine-appropriate lever that was similar to that seen after 0.16 mg/kg administration. The results of this behavioral experimentation are consistent with the notion that d-amphetamine, amfonelic acid and apomorphine may produce their dopaminergic effects by different mechanisms of action and the possibility of two sites of action for n-propylnoraporphine is discussed.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001058:Apomorphine / Q000031:analogs & derivatives / Q000494:pharmacology*; D004193:Discrimination Learning / Q000187:drug effects*; D008297:Male; D009268:Nalidixic Acid / Q000031:analogs & derivatives; D009287:Naphthyridines / Q000494:pharmacology*; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects
D009287:Naphthyridines; D011954:Receptors, Dopamine; D009268:Nalidixic Acid; C009074:N-n-propylnorapomorphine; D000661:Amphetamine; D001058:Apomorphine; C006486:amfonelic acid