title: Bone destruction due to the rupture of a cholesteatoma sac: a pathogenesis of bone destruction in aural-cholesteatoma.
abstract: Severe bone destruction in a cholesteatoma is one of the characteristic clinical features. To clarify the mechanism of bone destruction in cholesteatoma, the matrix of cholesteatoma and the attached bone, obtained during middle ear surgery, was observed by light microscope. Rupture of the epithelial lining in a cholesteatoma and the escaping contents (keratin), which gave rise to intense characteristic granulations in subepithelial tissue, were found. Furthermore bone destruction was always found at the site of subepithelial tissue of cholesteatoma. From these facts, the escape of contents from the sac of cholesteatoma into the subepithelial layer is considered to be an important factor in the mechanism of bone destruction.
mesh_terms: D001862:Bone Resorption / Q000209:etiology*; D002781:Cholesteatoma / Q000150:complications* / Q000473:pathology; D004427:Ear Diseases / Q000150:complications* / Q000473:pathology; D006801:Humans; D010014:Osteolysis / Q000209:etiology* / Q000473:pathology; D012422:Rupture, Spontaneous