[Relationship between interstrain differences in the magnitude of the immune response to sheep erythrocytes and the nature of inheritance of response strength to antigen dose and means of administration].
Dependence of antibody response to sheep red blood cells on the antigen doze and route of its administration was studied in mice of inbred strains (CBA C57BL/6, BALB/c) and (CBA X C57BL/6)F1 and (CBA X BALB/c)F1 hybrids. The most significant strain differences in antibody response appear at the intravenous injection of low antigen dose (5 X 10(5) cells) and intramuscular injection of mean antigen dose (5 X 10(7) cells). As the immunization dose in increased, the strain differences decrease (between CBA and C57BL/6 mice) and disappear, (between CBA and and BALB/c mice). F1 was shown to be a poor responder to the intravenous injection of low antigen dose (5 X 10(5) cells) and intramuscular injection of the mean dose and to be a higher responder to the intravenous injection of a large dose of sheep red blood cells (10(7)--10(9) cells).
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000008:administration & dosage*; D004306:Dose-Response Relationship, Immunologic; D004912:Erythrocytes / Q000276:immunology*; D006824:Hybridization, Genetic; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA / Q000276:immunology; D008815:Mice, Inbred Strains / Q000276:immunology*; D012756:Sheep / Q000276:immunology; D013045:Species Specificity
D000941:Antigens
Zavisimost' mezhlineĭnykh razlichiĭ v vysote immunnogo otveta na éritrotsity barana i kharaktera nasledovaniia sily otveta ot dozy antigena i sposoba ego vvedeniia.