Sister chromatid exchange and chromosome aberration rates in a group of psoriatics before and after a course of PUVA treatment.
Blood was cultured and chromosome preparations were examined for sister chromatid exchanges and chromosome aberrations in eighteen patients receiving photochemotherapy with 8-MOP and UV-A for the treatment of psoriasis, both before starting treatment and again 6 months later. The UV-A was administered both by means of low output (irradiance: 1.1--2.25 mW/cm2) and high output (irradiance: 6.1--7.6 mW/cm2) UV-A radiation cubicles. Irrespective of the intensity of irradiation or the total dose of UV-A administered there was no evidence of chromosome damage in lymphocytes following treatment.
D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic / Q000528:radiation effects; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D010778:Photochemotherapy; D011565:Psoriasis / Q000188:drug therapy / Q000235:genetics*; D012854:Sister Chromatid Exchange / Q000528:radiation effects; D013997:Time Factors