[Role of aromatic amines in the induction of tumors of the urinary tract. Experimental evaluation of the DNA damage induced with naphthylamines].
DNA damage induced by 1-Naphtylamine and 2-Naphtylamine has been verified using alkaline elution technique. Single-stranded DNA breaks were evident in the liver and kidneys of mice treated within 4 hours from the injection. A difference in the organotropism of the two aromatic amines has been observed. These results improve the applicability of the technique and are interesting in order to obtain predictive evaluations on the carcinogenicity of the aromatic amines.
D015057:1-Naphthylamine / Q000009:adverse effects*; D015081:2-Naphthylamine / Q000009:adverse effects*; D000818:Animals; D004277:DNA, Single-Stranded; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D051379:Mice; D009281:Naphthalenes / Q000009:adverse effects*; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced*
D004277:DNA, Single-Stranded; D009281:Naphthalenes; D015057:1-Naphthylamine; D015081:2-Naphthylamine
Ruolo delle ammine aromatiche nell'induzione di tumori dell'apparato urinario. Valutazione sperimentale del danno al DNA indotto da naftilammine.