title: Effect of steroid hormones on the rat endometrium.
abstract: The effects of estradiol (E), progesterone (P), cortisol (C), and combinations of the three hormones on the uterus luminal epithelia, mitotic index, and leukocyte infiltration were studied. At 24 hours, E treated groups showed increased uterine weight. The highest weight increase was observed in groups treated with E alone, and the maximal atrophic picture in terms of the luminal epithelia was found in the group treated with C + P. At 48 hours, only E and C + E showed increased uterine weight. At 24 hours, all groups treated with E showed increased mitotic figures. The highest values were found in groups treated with E, and with C + E + P. At 24 hours, C and P inhibited the E effect. At 48 hours, only E and C + E treated groups showed a mitotic increase. It is proposed that C antagonizes P or potentiates some E actions.
mesh_terms: D000818:Animals; D004717:Endometrium / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006854:Hydrocortisone / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology; D051381:Rats; D013256:Steroids / Q000378:metabolism*
chemical_list: D013256:Steroids; D011374:Progesterone; D004958:Estradiol; D006854:Hydrocortisone