The effect of overnight biliary drainage on the hepatic excretion of bromosulphophthalein.
The excretion of bromosulphophthalein (BSP) was studied in rats after depletion of their bile salt pool by overnight biliary drainage. Peak biliary BSP excretion was significantly lower (80% of control value) in animals with a depleted bile salt pool; however, treatment with phenobarbital for 5 days before bile salt depletion prevented a reduction in BSP excretion. These studies support the observation that the hepatic excretion of bile salt is an important factor influencing the biliary excretion of BSP.
D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D001652:Bile Ducts / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D013448:Sulfobromophthalein / Q000378:metabolism*; D013997:Time Factors
D001647:Bile Acids and Salts; D013448:Sulfobromophthalein