Voltage-dependent elements are involved in the generation of the cochlear microphonic and the sound-induced resistance changes measured in scala media of the guinea pig.
The injection of d.c. current into scale media alters both the cochlear microphonic (CM) and the acoustically synchronized changing resistance (CR) measured in scala media. Positive current increases the CM and decreases the CR. The effect on the CM is greatest at high sound pressure level (SPL), whereas the effect on CR is greatest at low SPL. Negative current has a similar but opposite effect on both the CM and the CR. The results suggest that a voltage-dependent nonlinear element exists in cochlear hair cells.
D000161:Acoustic Stimulation; D000818:Animals; D003051:Cochlea / Q000502:physiology*; D003053:Cochlear Duct / Q000502:physiology* / Q000503:physiopathology; D003055:Cochlear Microphonic Potentials; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000502:physiology / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology