Aldehyde dehydrogenase inhibitors and voluntary ethanol drinking by rats.
Aldehyde dehydrogenase (ALDH) inhibitors, cyanamide (200 mg or 40 mg/kg food) and coprine (N5-(hydroxycyclopropyl)-L-glutamine, 500 mg/kg food), strongly suppressed, with similar time courses, the free-choice consumption of 10% v/v ethanol. The suppression occurred with both continual and alternate access to alcohol. The presence of the inhibitors (plus 4-methylpyrazole to prevent acetaldehyde accumulation) did not affect ethanol-induced (1.5 g/kg i.p.) motor impairment on the tilting plane, but the rats on alternate-day access, which consumed more alcohol on days of access, were significantly less impaired.
D000079:Acetaldehyde / Q000097:blood; D000428:Alcohol Drinking; D000445:Aldehyde Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D003484:Cyanamide / Q000494:pharmacology; D003521:Cyclopropanes / Q000494:pharmacology; D004361:Drug Tolerance; D000431:Ethanol / Q000494:pharmacology; D005973:Glutamine / Q000031:analogs & derivatives / Q000494:pharmacology; D004856:Postural Balance / Q000187:drug effects; D051381:Rats
D003521:Cyclopropanes; D005973:Glutamine; C014423:coprine; D000431:Ethanol; D003484:Cyanamide; D000445:Aldehyde Oxidoreductases; D000079:Acetaldehyde