[Effect of cholinergic substances on nociceptive evoked responses in specific thalamic nuclei].
The effect of the M-cholinomimetic arecoline and M-cholinolytic metamizil, n-cholinomimetic lobelin and n-cholinolytic -506 (beta-ethylenespasmolytin) on the formation of nociceptive responses induced by dental pulp stimulation was studied by means of microinjections into the rabbit thalamus preparations VPM and VPL. Arecoline and -506 decreased while metamizil and lobelin increased the amplitude of the primary responses. No changes in the latent periods were noted. It is concluded that the activation of the M-cholinergic structures of specific nuclei of the thalamus reduces the nociceptive responses. The activation of the N-cholinergic structures potentiates the nociceptive responses in specific relays.
D000818:Animals; D003782:Dental Pulp / Q000502:physiology; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D009619:Nociceptors / Q000187:drug effects*; D010277:Parasympathomimetics / Q000494:pharmacology*; D011817:Rabbits; D013787:Thalamic Nuclei / Q000187:drug effects*
D010277:Parasympathomimetics
Vliianie kholinergicheskikh veshchestv na notsitseptivnye vyzvannye otvety v spetsificheskikh iadrakh talamusa.