title: [Effect of mebikar on the state of animals under extreme conditions].
abstract: A new original tranquilizer mebicar exerts a protective action on some parameters of body function under the influence of extreme conditions (stress, hypoxia). Antihypoxic effect of the drug manifests within a wide dosage range (100-1000 mg/kg) and compares favourably with the effect of sodium hydroxybutyrate. Mebicar does not affect the muscle tone, movement coordination or working capacity of the animals. It is suggested that the normalizing action of mebicar as tranquilizer and antihypoxic agent may be related to its involvement in metabolism.
mesh_terms: D000818:Animals; D001736:Biureas / Q000627:therapeutic use*; D001643:Bridged Bicyclo Compounds / Q000627:therapeutic use*; D001952:Bridged-Ring Compounds / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000188:drug therapy; D051379:Mice; D051381:Rats; D012149:Restraint, Physical; D012978:Sodium Oxybate / Q000627:therapeutic use; D013312:Stress, Physiological / Q000188:drug therapy*; D013997:Time Factors; D014149:Tranquilizing Agents
chemical_list: D001736:Biureas; D001643:Bridged Bicyclo Compounds; D001952:Bridged-Ring Compounds; D014149:Tranquilizing Agents; C015979:mebikar; D012978:Sodium Oxybate
vernacular_title: Vliianie mebikara na sostoianie zhivotnykh pri nekotorykh ékstremal'nykh vozdeĭstviiakh.