title: Sister chromatid exchanges and chromosome aberrations in children after treatment for malignant lymphoma.
abstract: Sister chromatid exchanges and chromosomal aberrations were investigated in lymphocytes from 11 children with malignant lymphoma after cessation of treatment. Chemotherapy combined with radiation was administered, terminating between 4 months and 13 years before chromosome analyses were performed. The frequency of sister chromatid exchanges per chromosome was the same, 0.20, in the patients and a matched control group, although there was a significant heterogeneity between individuals. The number of cells with chromosome abnormalities increased from 2.9% in control children to 4.8% in treated patients, a nonsignificant increase. Only translocations showed a significant increase.
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic / Q000187:drug effects; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000628:therapy*; D008297:Male; D011878:Radiotherapy / Q000009:adverse effects*; D012854:Sister Chromatid Exchange / Q000187:drug effects / Q000528:radiation effects
chemical_list: D000970:Antineoplastic Agents