Toxic synergism of disopyramide and hyperkalemia.
A patient is presented whose electrocardiogram became remarkably abnormal and who developed hypotension while receiving disopyramide and potassium. This report documents a potassium-disopyramide synergism leading to life-threatening toxicity. These abnormalities were corrected by glucose, insulin and bicarbonate therapy, suggesting that serious disopyramide toxicity may be enhanced by hyperkalemia and reversed by lowering the serum potassium.
D000368:Aged; D004206:Disopyramide / Q000633:toxicity*; D004357:Drug Synergism; D004562:Electrocardiography; D006801:Humans; D006947:Hyperkalemia / Q000175:diagnosis / Q000503:physiopathology*; D007022:Hypotension / Q000139:chemically induced; D008297:Male; D011188:Potassium / Q000633:toxicity*; D011725:Pyridines / Q000633:toxicity*
D011725:Pyridines; D004206:Disopyramide; D011188:Potassium