[Dynamics of changes in the estradiol receptor content in the nuclear fraction of the hypothalamus of female rats during ontogenesis].
Determination of estradiol receptors content in the nuclear fraction of the female rats' hypothalamus demonstrated their number to alter during the postnatal development. Numerous nuclear E2-binding sites were revealed in the hypothalamus of 14-day-old female rats. The E2-binding level fell by the 21st day after birth, persisting at this level up to sexual maturity. The nuclear receptor content was maximal at this age period. Estradiol receptors possessed a high degree of affinity to the recepted hormone, and also specificity. Estradiol nuclear receptors were revealed in the brain cortex only in 7-day-old rats.
D000375:Aging; D000818:Animals; D001667:Binding, Competitive; D002467:Cell Nucleus / Q000378:metabolism*; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D007031:Hypothalamus / Q000648:ultrastructure*; D051381:Rats; D011960:Receptors, Estrogen / Q000378:metabolism*
D011960:Receptors, Estrogen; D004958:Estradiol
Dinamika izmeneniia soderzhaniia retseptorov k éstradiolu v iadernoĭ fraktsii gipotalamusa samok krys v khode ontogeneza.