The effect of acetylsalicylic acid (ASA) on the development of atherosclerotic lesions in miniature swine.
A study was undertaken to determine the effects of acetylsalicylic acid (ASA) on the development of injury-induced atherosclerosis in swine. Treatment of mini-pigs with 30 mg/kg of ASA twice daily for 4 weeks significantly inhibited intimal thickening caused by 2 consecutive balloonings. The effect was accompanied by a 30% reduction in aortic collagen. ASA thus appears to exert a protective effect in injury-induced atherosclerosis.
D000818:Animals; D001012:Aorta, Abdominal / Q000293:injuries / Q000473:pathology; D001161:Arteriosclerosis / Q000378:metabolism / Q000473:pathology / Q000517:prevention & control*; D001241:Aspirin / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D003094:Collagen / Q000378:metabolism; D008297:Male; D013552:Swine
D003094:Collagen; D002784:Cholesterol; D001241:Aspirin