Dose-dependent neurochemical effects of 1,1,2-trichloro-1,2,2-trifluoroethane inhalation exposure in rats.
Male Wistar rats were exposed to 200, 1000 or 2000 ppm of 1,1,2-trichloro-1,2,2-trifluoroethane vapour for 2 weeks, 5 day/week, 6 h daily and showed a dose-dependent accumulation of the compound in perirenal fat and brain. In the first week increased NADPH-diaphorase activity was observed and there was decreased cerebral glutathione at the highest dose. During the second week these effects disappeared while RNA tended to increase, and glutathione peroxidase activity to decrease at the highest dose. After a withdrawal period of 7 days, no fluorohydrocarbon was detected and the neurochemical effects had disappeared except that brain RNA at the highest exposure was below the control range.
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D006843:Hydrocarbons, Chlorinated / Q000633:toxicity*; D006845:Hydrocarbons, Fluorinated / Q000633:toxicity*; D008297:Male; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism; D009252:NADPH Dehydrogenase / Q000378:metabolism; D051381:Rats; D014240:Trichloroethanes / Q000633:toxicity
D006843:Hydrocarbons, Chlorinated; D006845:Hydrocarbons, Fluorinated; D014240:Trichloroethanes; D005979:Glutathione Peroxidase; D009247:NADH, NADPH Oxidoreductases; D009252:NADPH Dehydrogenase; D005978:Glutathione