Formation of hydrogen peroxide in normal and copper-treated rat endometrium.
An intrauterine copper device stimulated endogenous hydrogen peroxide formation in whole homogenates and in the mitochondrial and microsomal (but not the nuclear) fractions of rat endometrial tissues. Uric acid also accumulated in the endometrium of copper-treated rats, but not in those fitted with a nylon device or sham operated. It is suggested that the contraceptive effect of copper may be related to these events.
D000818:Animals; D003300:Copper / Q000494:pharmacology; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D006861:Hydrogen Peroxide / Q000378:metabolism*; D007434:Intrauterine Devices; D007435:Intrauterine Devices, Copper; D009757:Nylons; D051381:Rats; D014527:Uric Acid / Q000096:biosynthesis
D009757:Nylons; D014527:Uric Acid; D003300:Copper; D006861:Hydrogen Peroxide