Acidified glycerol lysis test: a screening test for spherocytosis.
Acidified glycerol lysis test (AGLT) is a screening procedure which has been developed for spherocytosis. AGLT was found positive in 100% of 48 patients suffering from hereditary spherocytosis, 100% of nine couples of affected parents, and 86% of 14 couples of clinically healthy parents. The test was positive in acquired spherocytosis and negative in normal controls. AGLT appears to have a predictive value higher than the entire battery of conventional tests. It is simple, rapid, inexpensive, gives clear-cut results and requires minute amounts of blood. It can be performed on blood stored for up to 24 h.
D000328:Adult; D000740:Anemia / Q000097:blood; D005260:Female; D005990:Glycerol; D006461:Hemolysis; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008722:Methods; D009996:Osmotic Fragility; D011247:Pregnancy; D013103:Spherocytosis, Hereditary / Q000175:diagnosis*
D005990:Glycerol