Myocardial imaging and metabolic studies with [17-123I]iodoheptadecanoic acid.
After intravenous administration of the stearic acid analogue [17-123I]iodoheptadecanoic acid (I-123 HA), myocardial metabolism was studied in ten normal individuals, eight patients with coronary artery disease and three patients with congestive heart failure. High-quality images were obtained in sequential scintigraphy of I-123 metabolically bound in myocardial tissue. Infarcted zones as well as ischemic regions are indicated by reduced tracer uptake. Iodine-123 in the blood pool and interstitial space consists mainly of radioiodide that is liberated by fatty-acid metabolism and was corrected for. Using the proposed correction not only are the images improved but the uptake and elimination of the I-123 in the myocardial cells can be followed. The average disappearance half-time of I-123 HA from the myocardium of normal persons was 24 +/- 4.7 min. In patients with coronary artery disease significant differences between myocardial regions were observed.
D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000000981:diagnostic imaging; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006207:Half-Life; D006321:Heart / Q000000981:diagnostic imaging*; D006331:Heart Diseases / Q000097:blood / Q000000981:diagnostic imaging* / Q000378:metabolism; D006333:Heart Failure / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism; D011877:Radionuclide Imaging
D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D007457:Iodine Radioisotopes; C027252:17-iodoheptadecanoic acid