The effect of the pesticides, Dexon, Captan and Roundup, on sister-chromatid exchanges in human lymphocytes in vitro.
3 pesticides at varying concentrations were tested for the induction of SCE in human lymphocytes in vitro. The fungicide, Dexon, sodium (4-(dimethylamino)phenyldiazene sulfate, was found to cause the greatest increase in SCE frequency and the response is dose related. The herbicide, Roundup, isopropylamine salt of N-(phosphonomethyl)glycine, had the lest effect on SCE requiring the use of much higher concentrations to produce an effect. Limited results were obtained with the fungicide Captan, cis-N-((trichloromethyl)thio)-4-cyclohexene-1, 2-dicarboximide because of toxic levels of either the fungicide or solvent used.
D001391:Azo Compounds / Q000494:pharmacology; D001557:Benzenesulfonates / Q000494:pharmacology*; D002215:Captan / Q000494:pharmacology*; D002478:Cells, Cultured; D002842:Chromatids / Q000187:drug effects; D003434:Crossing Over, Genetic; D004305:Dose-Response Relationship, Drug; D005659:Fungicides, Industrial / Q000494:pharmacology*; D005998:Glycine / Q000031:analogs & derivatives* / Q000494:pharmacology; D006540:Herbicides / Q000494:pharmacology*; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D009152:Mutagenicity Tests; D009153:Mutagens; D012854:Sister Chromatid Exchange; D000097797:Glyphosate
D001391:Azo Compounds; D001557:Benzenesulfonates; D002215:Captan; D005659:Fungicides, Industrial; D005998:Glycine; D006540:Herbicides; D009153:Mutagens; D000097797:Glyphosate; C007287:dexon (fungicide), sodium salt