The effect of cyproterone acetate on serum lipids in normal men.
In a male anti-fertility study 7 volunteers received the anti-androgen cyproterone acetate (5 or 10 mg daily) orally in a paired study. A significant reduction in serum-cholesterol and LDL-cholesterol, and a significant increase in the intravenous-fat-tolerance-test (IVFTT) was observed. Thus low doses of cyproterone acetate reduced the serum testosterone concentration and some of the atherosclerotic risk factors.
D000328:Adult; D002784:Cholesterol / Q000097:blood; D003534:Cyproterone / Q000494:pharmacology*; D005217:Fat Emulsions, Intravenous; D006493:Heparin / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000097:blood*; D008071:Lipoprotein Lipase / Q000097:blood; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D014280:Triglycerides / Q000097:blood
D005217:Fat Emulsions, Intravenous; D008055:Lipids; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D014280:Triglycerides; D006493:Heparin; D002784:Cholesterol; D003534:Cyproterone; D008071:Lipoprotein Lipase