Retinotoxic effects of diaminodiphenoxybutane in rats.
The effects of diaminodiphenoxybutane (DAPB) on visual function in rats were studied using behavioral, electrophysiological and histological techniques. A light-dark discrimination test was conducted by an operant behavioral method. DAPB did not modify intensity detection threshold at an intravenous dose of 35 mg/kg, but elevated it at doses of 50 and 70 mg/kg. Secondly, DAPB did not produce any changes in either electroretinogram (ERG) or visually evoked potential (VEP) at the dose of 35 mg/kg, but a marked decrease in the amplitude of the ERG a- and b-waves appeared after the doses of 50 and 70 mg/kg. The latency of the VEP first wave was also prolonged dose-dependently. Finally, retinal lesions were revealed in rats receiving 70 mg/kg. These results indicate that DAPB has a toxic effect on the retina in rats.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D003216:Conditioning, Operant / Q000187:drug effects; D003959:Diamines / Q000494:pharmacology*; D004558:Electric Stimulation; D004596:Electroretinography; D005071:Evoked Potentials / Q000187:drug effects; D008297:Male; D051381:Rats; D012164:Retinal Diseases / Q000139:chemically induced* / Q000473:pathology
D003959:Diamines; C027228:diaminodiphenoxybutane