Effect of multiple excretory urograms on glomerular filtration of normal dogs: a preliminary report.
Study was made of the effect of a triiodinated radiopaque contrast agent, sodium iothalamate on glomerular filtration of ten normal dogs given the dosages commonly recommended for diagnostic studies--200, 400, and 800 mg of iodine/0.45 kg of body weight administered at 2- to 6-day intervals. Renal function was evaluated by determination of serum urea nitrogen and serum creatinine concentrations and endogenous creatinine clearance immediately before each urogram and at 2 to 5 days after the last urogram. Although no significant changes in serum urea nitrogen or creatinine concentrations were identified, a statistically significant reduction in endogenous creatinine clearance following urography was identified when the data from all the dogs were evaluated as a group. However, only 3 of the 10 dogs had successively decreasing values on serial evaluations of endogenous creatinine clearances and an additional 2 animals had final endogenous creatinine clearances further than 1 SD below the preinjection (base line) mean for that animal. Serial renal function studies will be required in dogs given a single dose of the radiopaque contrast to determine the reversibility of the decreased endogenous creatinine clearance and the significance of the decreased creatinine clearances when compared with those values in control dogs (not given radiopaque contrast medium). In addition, these studies may reveal whether the incidence, degree, and duration of reduced glomerular filtration are related to the dose rate of radiopaque contrast agent and are statistically significant were greater numbers of dogs given single and multiple doses of radiopaque contrast agent under laboratory conditions.
D000818:Animals; D001806:Blood Urea Nitrogen; D003404:Creatinine / Q000097:blood; D004285:Dogs / Q000502:physiology*; D005919:Glomerular Filtration Rate; D014567:Urography / Q000662:veterinary*
D003404:Creatinine