In vivo 3H-d-LSD binding in small punched out rat brain regions.
We have developed an in vivo 3H-d-LSD-binding method in the rat brain to measure the 3H-d-LSD concentration in specific brain regions and nuclei. In the cortex, d-LSD binding sites increase from the occipital to the frontal part without a change in their affinity. Compared to the hippocampus, striatum, cortex and raphe nuclei, the substantia nigra contains a d-LSD binding site of lower affinity.
D000818:Animals; D001665:Binding Sites; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D002540:Cerebral Cortex / Q000378:metabolism; D007700:Kinetics; D008238:Lysergic Acid Diethylamide / Q000378:metabolism*; D008297:Male; D009928:Organ Specificity; D051381:Rats; D011955:Receptors, Drug / Q000378:metabolism
D011955:Receptors, Drug; D008238:Lysergic Acid Diethylamide