title: Glycine metabolism and glycine synthase activity during the postnatal development of rat brain.
abstract: Glycine synthase from rat brain mitochondria shows an apparent Km for glycine of 2.6 mM. Glycine synthase from rat brain homogenate has a maximum of activity at the 10th day of life. However, each area of the central nervous system shows a different developmental pattern of glycine synthase activity. Both the 14CO2 production from (U-14C)-glycine and the incorporation of the radioactivity from the (U-14C)-glycine to the acid-insoluble fraction by cortex slices has a developmental profile similar to the glycine synthase activity in this area, having a maximum on the 10th day.
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D050960:Aminomethyltransferase; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000254:growth & development* / Q000378:metabolism; D002540:Cerebral Cortex / Q000201:enzymology / Q000378:metabolism; D005998:Glycine / Q000378:metabolism*; D050841:Glycine Dehydrogenase (Decarboxylating); D019877:Hydroxymethyl and Formyl Transferases; D008928:Mitochondria / Q000201:enzymology; D051381:Rats; D014166:Transferases / Q000378:metabolism*
chemical_list: D000594:Amino Acid Oxidoreductases; D050841:Glycine Dehydrogenase (Decarboxylating); D014166:Transferases; D019877:Hydroxymethyl and Formyl Transferases; D050960:Aminomethyltransferase; D005998:Glycine