Combined immunodeficiency of Arabian horses: confirmation of autosomal recessive mode of inheritance.
A 3-year prospective breeding trial was designed to verify the mode of inheritance of combined immunodeficiency (CID) in Arabian horses. Twenty-six mares that had previously produced foals with CID were mated to a stallion that had sired foals with CID. Of 53 foals obtained, 15 (28.3%) had CID. The ratio of female to male foals was 28:25, and the ratio of female CID to male CID foals was 8:7. The results of this trial confirmed a suggestion that CID in Arabian horses is inherited as an autosomal recessive trait.
D000818:Animals; D004406:Dysgammaglobulinemia / Q000235:genetics / Q000662:veterinary; D005260:Female; D006734:Horse Diseases / Q000235:genetics*; D006736:Horses; D007075:Immunoglobulin M / Q000172:deficiency; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000662:veterinary*; D008231:Lymphopenia / Q000235:genetics / Q000662:veterinary; D008297:Male
D007075:Immunoglobulin M