title: Early replication of Friend leukaemia viruses in spleen macrophages.
abstract: The ability of spleen macrophages to support Friend leukaemia virus replication was studied by testing for infectivity in adherent cells obtained from mice at various times after infection. Virus-releasing macrophages appeared early after infection and reached a high proportion. The released virus was probably synthesized de novo since macrophage infectivity was strongly reduced by treatments which affected cellular viability or synthetic activities and electron microscopy showed C-type particles budding from macrophages.
mesh_terms: D000818:Animals; D005615:Freezing; D005622:Friend murine leukemia virus / Q000254:growth & development*; D008264:Macrophages / Q000382:microbiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D010142:Pactamycin / Q000494:pharmacology; D013154:Spleen / Q000166:cytology; D014357:Trypsin / Q000494:pharmacology
chemical_list: D010142:Pactamycin; D014357:Trypsin