C4 receptors in the human glomeruli.
Glomeruli in cryostat sections of human renal tissues adsorbed sheep erythrocytes sensitized with the fourth component of human complement (C). The receptors had specificity for the C4b fragment of C4, and were uniformly distributed in the glomeruli. The receptors were sensitive to trypsin and to periodic acid and were blocked in vivo and in vitro by C3 and C4. Receptors in fetal and adult renal tissues and in areas outside in vivo deposits of C in biopsy specimens had similar avidity. Further results suggested that the receptors for C4b are identical to the receptors for C3b, or that the receptors are located on closely related structures.
D003176:Complement C3 / Q000378:metabolism; D003181:Complement C4 / Q000378:metabolism*; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology*; D011951:Receptors, Complement / Q000032:analysis / Q000276:immunology*
D003176:Complement C3; D003181:Complement C4; D011951:Receptors, Complement