title: The effect of Apamin on nonadrenergic, noncholinergic nervous vasodilatations in the cat small intestine.
abstract: The intestinal vasodilation evoked by mechanical mucosal stimulation or by transmural electrical field stimulation was abolished by close i.a. injection of Apamin, a polypeptide originally isolated from bee venom. Apamin also blocked the vasodilatation induced by close i.a. infusion of vasoactive intestinal polypeptide (VIP). It is suggested that Apamin is a VIP receptor antagonist.
mesh_terms: D000818:Animals; D001030:Apamin / Q000494:pharmacology*; D001514:Bee Venoms / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D007413:Intestinal Mucosa / Q000098:blood supply* / Q000187:drug effects; D007421:Intestine, Small / Q000098:blood supply* / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*
chemical_list: D001514:Bee Venoms; D001030:Apamin