title: [Alteration of bronchial flow resistance due to timolol 0.25% in bronchial asthma (author's transl)].
abstract: A woman patient suffering from long-term pulmonary asthma was treated with steroids and developed a secondary glaucoma. After the first application of one drop of Timololmaleat 0,25% in the lower conjunctival sac of each eye a significant increase in bronchospasm was registered. The cause and consequences of this side-effect are discussed. Timolol is contraindicated for patients with pulmonary disease as long as a negative effect on the pulmonary system is not ruled out by pulmonary tests.
mesh_terms: D001249:Asthma / Q000188:drug therapy; D001986:Bronchial Spasm / Q000139:chemically induced*; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011412:Propanolamines / Q000009:adverse effects*; D013999:Timolol / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use
chemical_list: D009883:Ophthalmic Solutions; D011412:Propanolamines; D013999:Timolol
vernacular_title: Anderung des bronchialen Strömungswiderstandes bei asthma bronchiale durch einmalige lokale Applikation von Timolol 0,25% Augentropfen.