[Comparison of fenoterol (Berotec) with the antiallergic benzopyrene compound PR-D 92 and a placebo in regard to the cutaneous immediate reaction in allergic patients (author's transl)].
After discussion of today's knowledge of the mechanism of allergic reactions with particular regard to the adenylyl cyclase system a report is given on an experimental study in which Fenoterol (Berotec), PR-D 92 (Bisbenzopyran) as well as placebo were repeatedly applied to defined areas of the forearm of 30 patients with known pollen allergies. The expansion of the allergy-induced erythemae and weals was exactly measured. A comparison of the sizes showed approximately 50% inhibition of the reaction following application of Berotec, the difference being highly significant compared with PR-D 92 and placebo. There was no statistical difference between the last two.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001580:Benzopyrenes / Q000627:therapeutic use*; D002648:Child; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000627:therapeutic use*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D010919:Placebos; D011058:Pollen
D001580:Benzopyrenes; D004983:Ethanolamines; D010919:Placebos; D005280:Fenoterol
Wirkungsvergleich von Fenoterol (Berotec) mit einem Antiallergikum aus der Reihe der Benzopyrane (PR-D 92) unter Placebo-Kontrolle bei der Kutanen Sofortreaktion des Menschen.