Tumor inhibitory triazenes. 2. Variation of antitumor activity within an homologous series.
An homologous series of water-soluble, chemically stable analogues of 5-(3,3-dimethyl-1-triazeno)imidazole-4-carboxamide (DTIC) has been prepared with activity comparable to DTIC in an experimental tumor system. The antitumor activity of this series of 3-alkyl-1-(4-carboxyphenyl)-3-methyltriazenes rapidly diminishes at alkyl chain lengths greater than pentyl. Partition coefficients were determined, but no relationship between these and antitumor activity could be established.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D005260:Female; D008223:Lymphoma / Q000188:drug therapy; D051379:Mice; D008808:Mice, Inbred CBA; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012995:Solubility; D013329:Structure-Activity Relationship; D014226:Triazenes / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D014226:Triazenes