Photoaugmentation in drug phototoxicity.
The phototoxic reaction to chlorpromazine and other drugs is provoked by long-wave ultraviolet light (UVA). It was shown by the in vivo mouse tail technique that the reaction is enhanced by medium-wave ultraviolet light (UVB), thus demonstrating the importance of photoaugmentation in this process.
D000818:Animals; D002707:Chlordiazepoxide / Q000009:adverse effects; D002746:Chlorpromazine / Q000009:adverse effects; D005260:Female; D008730:Methoxsalen / Q000009:adverse effects; D051379:Mice; D010787:Photosensitivity Disorders / Q000209:etiology*; D011829:Radiation Dosage; D014466:Ultraviolet Rays / Q000009:adverse effects*
D002707:Chlordiazepoxide; D002746:Chlorpromazine; D008730:Methoxsalen