Effects of salicylate on intestinal absorption: in vitro and in vivo studies with enterotoxigenic micro-organisms.
This study was done to determine whether salicylate could affect alterations in intestinal absorption induced by preparations of enterotoxigenic micro-organisms. It was found in rats that salicylate increased intestinal monosaccharide uptake in vitro and reversed the inhibitory effects induced by cell-free preparations of Staphylococcus sp., Candida sp. and Klebsiella sp. In vivo, salicylates increased net water absorption in rat jejunum exposed to cell-free preparations of various micro-organisms. Increase in net fluid flux occurred after subcutaneous injection only with bacteria which stimulate adenylate cyclase activity. These observations suggest that the absorptive and anti-secretory effects of aspirin are cyclic nucleotide dependent. The potential clinical role of salicylates as anti-secretory agents in diarrhoeal diseases, particularly in children, requires further investigation.
D000818:Animals; D001104:Arbutin / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology*; D001427:Bacterial Toxins / Q000494:pharmacology; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000187:drug effects*; D007583:Jejunum / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009183:Mycotoxins / Q000494:pharmacology; D051381:Rats; D014867:Water / Q000378:metabolism
D001427:Bacterial Toxins; D009183:Mycotoxins; D014867:Water; D001104:Arbutin; D001241:Aspirin