title: [The effects of dihydroergotamine on the circulatory system of man during neurolept analgesia (author's transl)].
abstract: The effect of 0.015 mg/kg KHE i.v. on the circulatory system was investigated in 10 patients after closure of an atrial septal defect under neuroleptanalgesia. The arterial pressure increased due to an increase of total systemic resistance. The filling pressures of the right and the left ventricle increased while the stroke index remained unchanged. The maximal rate of rise of left ventricular pressure did not change despite the marked changes of pre- and afterload. The data support the drug mechanism of a volume shift from the peripheral to the central circulation. The possible reasons for the missing stroke index increase are discussed.
mesh_terms: D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D004087:Dihydroergotamine / Q000494:pharmacology*; D006344:Heart Septal Defects, Atrial / Q000601:surgery; D006801:Humans; D008875:Middle Aged; D009458:Neuroleptanalgesia; D013318:Stroke Volume / Q000187:drug effects
chemical_list: D004087:Dihydroergotamine
vernacular_title: Die Wirkungen von Dihydroergotamin auf Herz und Kreislauf des Menschen unter Neuroleptanalgesie.