Metabolism of propachlor by the germfree rat.
Three major metabolites of propachlor were isolated from the excreta of germfree rats given 14C-labeled propachlor orally. In contrast, 11 urinary metabolites, six of which were 2-methylsulfonylacetanilides not present in excreta of germfree rats, were isolated from control rats given 14C-labeled propachlor orally. Enterohepatic circulation and microbial metabolism in the intestine were necessary for production of the methylsulfonyl-containing and other metabolites of propachlor in the conventional rat.
D000083:Acetanilides / Q000378:metabolism*; D000818:Animals; D004764:Enterohepatic Circulation; D005856:Germ-Free Life; D005978:Glutathione / Q000378:metabolism; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000382:microbiology*; D008099:Liver / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats
D000083:Acetanilides; C011088:propachlor; D005978:Glutathione