Morphopharmacological analysis of the carcinogenic properties of N-methyl-N'-nitro-N-nitrosoguanidine.
The modifying influence of atropine and reserpine on N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) induction of stomach tumors was studied in experiments on 120 random-bred male white rats. At the same time, pharmacological analysis of the mechanism of the carcinogenic action of MNNG was carried out. Atropine stimulated and reserpine markedly inhibited the carcinogenic effect of MNNG. MNNG interference altered the specific effects of amphetamine and phenobarbital. These alterations are due to the MNNG damage of the permeability of the presynaptic membrane of the central adrenergic structures. The leading role of adrenergic influences on the presence of carcinogenic transformation of stomach cell processes is discussed.
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology*; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology*; D009420:Nervous System / Q000187:drug effects; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D013270:Stomach / Q000473:pathology; D013274:Stomach Neoplasms / Q000139:chemically induced* / Q000473:pathology; D013570:Synaptic Membranes / Q000187:drug effects
D008769:Methylnitronitrosoguanidine; D001285:Atropine; D012110:Reserpine; D000661:Amphetamine; D010634:Phenobarbital