[Pharmacological effects on the motor activity of Oddi's sphincter. Postoperative electromanometric measurements of the bile ducts].
Besides the high diagnostical value of the electromanometric measurement, this method is especially useful for the registration of pharmacological effects upon the sphincter of Oddi. In this study the influence of hymecromon on sphincter function was tested in 138 patients. Hymecromon induced a significant decrease of pressure by prolonging the opening time (p < 0.001). In clinical experiments it could be shown that the increase of pressure induced by morphine in the common bile duct could be equalized by hymecromon within a short time. Depending significantly on the dosage (p < 0.01) there were identical results on the intravenous or intraductal application of hymecromon. An increase of activity of the liver-specific enzymes could not be seen after hymecromon treatment.
D014670:Ampulla of Vater / Q000187:drug effects*; D001652:Bile Ducts / Q000502:physiology / Q000601:surgery; D004594:Electrophysiology; D005260:Female; D005769:Gastrointestinal Motility / Q000187:drug effects*; D006801:Humans; D006923:Hymecromone / Q000494:pharmacology*; D008297:Male; D008365:Manometry / Q000379:methods; D008875:Middle Aged; D011184:Postoperative Period; D009803:Sphincter of Oddi / Q000187:drug effects*; D014468:Umbelliferones / Q000494:pharmacology*
D014468:Umbelliferones; D006923:Hymecromone
Pharmakologische Beeinflussung der Sphincter Oddi-Motorik. Postoperative Elektromanometrie der Gallenwege.