[Peculiar features of the effect of cobalamines on the metabolism of vitamin B 12 and pantothenic acid in B 12 deficiency].
A single parenteral administration to B12-deficient rats of cyan cobalamine (CN-Cbl), oxycobalamine (OH-Cbl), methyl cobalamine (CH3-Cbl) and adenosyl cobalamine (Ado-Cbl) at a dose of 100 microgram/kg body weight increased the lowered level of total cobalamines in the liver to reach or exceed the norm. The study of cobalamine-protein complexes (CPC) in the liver of B12-deficient rats showed that the content of free cobalamines and CPC was decreased, the level of CPC degrading at 80 degrees C being particularly low. An administration of OH-Cbl and CH3-Cbl raised significantly the content of CPC degrading at 80 degrees C and presumably containing Ado-Cbl. Under the influence of cobalamines the increased activity of alpha-ketoglutarate dehydrogenase in hepatocytes returned to the normal and the CoA level declined only after administration of CN-Cbl and CH3-Cbl.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D010205:Pantothenic Acid / Q000378:metabolism*; D051381:Rats; D014805:Vitamin B 12 / Q000378:metabolism* / Q000494:pharmacology*; D014806:Vitamin B 12 Deficiency / Q000378:metabolism*
D010205:Pantothenic Acid; D014805:Vitamin B 12
Osobennosti deĭstviia kobalaminov na pokazateli obmena vitamina B12 i pantotenovoĭ kisloty pri B12-nedostatochnosti.