title: Susceptibility to chemotherapeutic agents of strains of Schistosoma mansoni isolated from treated and untreated patients.
abstract: Seven strains of Schistosoma mansoni were isolated from the feces of patients. Three of the patients had been unsuccessfully treated with hycanthone or oxamniquine; the remaining four had not been given any specific treatment. Mice infected with these strains were treated 45 days later with niridazole (50 or 100 mg/kg body weight per day for 5 days, per os), hycanthone (single dose of 80 or 160 mg/kg, intramuscularly), or oxamniquine (single dose of 50 or 100 mg/kg, per os). Significant differences in the strains' responses to the schistosomicidal agents used were observed. Oogram changes in mice treated with the same drug ranged from 10--100%, and percentages of dead worms from 0--45. Such differences seemed to be dependent on the strain's specific characters rather than t their having been exposed to schistosomicidal drugs.
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D002648:Child; D005260:Female; D006801:Humans; D006826:Hycanthone / Q000627:therapeutic use; D008297:Male; D051379:Mice; D009560:Niridazole / Q000627:therapeutic use; D010073:Oxamniquine / Q000627:therapeutic use; D010270:Parasite Egg Count; D012550:Schistosoma mansoni / Q000187:drug effects; D012552:Schistosomiasis / Q000188:drug therapy*; D013045:Species Specificity
chemical_list: D010073:Oxamniquine; D006826:Hycanthone; D009560:Niridazole