[Synergistic or antagonistic interaction between dopamine and droperidol (DHB) on general hemodynamics and kidney function. An animal experiment study].
We investigated the renal effects of low and high concentrations of dopamine (4 and 10 microgram . kg-1 . min-1) in dog experiments. Dopamine increased renal blood flow, glomerular filtration rate, renal oxygen consumption and urinary excretion. These effects could not be antagonized by droperidol. In clinical doses both drugs rather act synergistically upon the cardiovascular system and renal function.
D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology*; D004329:Droperidol / Q000494:pharmacology*; D004357:Drug Synergism; D005919:Glomerular Filtration Rate; D006439:Hemodynamics / Q000187:drug effects*; D007668:Kidney / Q000098:blood supply / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D012039:Regional Blood Flow / Q000187:drug effects
D004329:Droperidol; D004298:Dopamine
Synergistische bzw. antagonistische Wirkung zwischen Dopamin und Droperidol (DHB) auf die allgemeine Hämodynamik und die Nierenfunktion. Tierexperimentelle Untersuchungen.