Effects of isoproterenol on the toxicity in rats of compounds eliminated by the kidneys.
In rats, l-isoproterenol (0.3 mg kg-1 s.c.) reduced the "average total body clearance" (as measured by dose/AUC) and the LD50 of various compounds that are eliminated almost entirely by the kidneys. These effects involve beta-adrenergic receptors since they are blocked by propranolol. Propranolol pretreatment prevented the isoproterenol-induced decreases in renal clearances of methoxy-inulin and tetraethylammonium bromide. Treatment with the alpha-adrenergic-blocking agent, phentolamine, potentiated the decreses in the renal clearances of these substances. The effects of isoproterenol were as marked in hypophysectomized as in intact rats. Peak plasma levels of isoproterenol after subcutaneous administration (0.3 mg kg-1) were about 42 ng ml-1.
D000818:Animals; D004347:Drug Interactions; D005919:Glomerular Filtration Rate; D006584:Hexamethonium Compounds / Q000378:metabolism; D007016:Hypophysectomy; D007545:Isoproterenol / Q000633:toxicity*; D007668:Kidney / Q000378:metabolism*; D007928:Lethal Dose 50; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats
D006584:Hexamethonium Compounds; D011433:Propranolol; D007545:Isoproterenol; D010646:Phentolamine