title: Marrow hypoplasia with splenomegaly in adolescence.
abstract: Four adolescents presented with leucopenia, thrombocytopenia, and splenomegaly; three had associated congenital abnormalities and two had a cirrhosis. They provide further evidence of an association between hepatic disease and bone marrow dysfunction. It is considered that these patients suffer from a genetic or constitutional disorder which may result in a susceptibility of their bone marrow to hypoplasia following viral hepatitis or other infections.
mesh_terms: D000293:Adolescent; D000328:Adult; D001853:Bone Marrow / Q000473:pathology; D001855:Bone Marrow Diseases / Q000209:etiology* / Q000473:pathology; D005260:Female; D006801:Humans; D007970:Leukopenia / Q000209:etiology; D008107:Liver Diseases / Q000150:complications; D008297:Male; D013163:Splenomegaly / Q000209:etiology*; D013921:Thrombocytopenia / Q000209:etiology