Antibody-mediated complement-dependent cytotoxicity in immunologically induced experimental colon disease.
Rabbits immunized with a saline extract of intestinal tissue in complete Freund's adjuvant produce antibody which mediates complement-dependent cytotoxicity for colon epithelial cells in vitro. The presence of this antibody did not correlate with histologic alterations of the colon in the immunized rabbits. This suggests that antibody-mediated complement-dependent cytotoxicity may not be a factor in the pathogenesis of experimentally induced immunologically mediated colon disease.
D000818:Animals; D000906:Antibodies; D000920:Antibody-Dependent Cell Cytotoxicity; D002448:Cell Adhesion; D003092:Colitis / Q000276:immunology*; D003106:Colon / Q000166:cytology / Q000473:pathology; D003176:Complement C3; D004848:Epithelium / Q000276:immunology; D006168:Guinea Pigs; D007074:Immunoglobulin G; D011817:Rabbits; D051381:Rats
D000906:Antibodies; D003176:Complement C3; D007074:Immunoglobulin G