[Effect of nitrofuran derivatives on the oxygen consumption by rat liver mitochondria].
Utilization of oxygen in rat liver mitochondria was studied using two nitrofuran derivatives 5-nitro-2-furaldehyde semicarbazone (furacin) and soluble derivative of nitrofuran--M-106-P. The substances at 10(-3) M concentration increased O2 consumption in mitochondria with simultaneous decrease in the respiratory control. After blocking of respiration with KCN, antimycine, rhothenone, the nitrofurans stimulated O2 consumption in mitochondria up to 30% as compared with controls.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004579:Electron Transport / Q000187:drug effects; D066298:In Vitro Techniques; D008930:Mitochondria, Liver / Q000187:drug effects*; D009581:Nitrofurans / Q000494:pharmacology*; D010101:Oxygen Consumption / Q000187:drug effects*; D051381:Rats
D009581:Nitrofurans
Vliianie nekotorykh nitrofuranovykh proizvodnykh na potreblenie kisloroda mitokhondriiami pecheni krys.