title: A high incidence antibody (anti-Sc3) in the serum of a Sc:-1,-2 patient.
abstract: An individual has been found whose red blood cells type as Sc:-1,-2, and do not absorb or yield on elution, anti-Sc1 or anti-Sc2. The patient produced an antibody reacting with all red blood cells, except those that were Sc:-1,-2. The antibody, here called anti-Sc3, was shown not to contain separable specificities when absorption studies were performed with Sc:-1,2 and Sc:1,-2 red blood cells. It appears that all Sc:1 or Sc:2 red blood cells are also Sc:3, while those that are Sc:-1,-2 are Sc:-3. A family study did not reveal the genetic background responsible for this Sc:-1,-2 phenotype.
mesh_terms: D000368:Aged; D000918:Antibody Specificity; D001789:Blood Group Antigens / Q000276:immunology*; D003298:Coombs Test; D006801:Humans; D008297:Male; D010375:Pedigree; D010641:Phenotype
chemical_list: D001789:Blood Group Antigens