Studies on the regulation of leucine catabolism. Mechanism responsible for oxidizable substrate inhibition and dichloroacetate stimulation of leucine oxidation by the heart.
D042942:3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); D000085:Acetates / Q000494:pharmacology*; D000597:Amino Acids, Branched-Chain / Q000037:antagonists & inhibitors / Q000378:metabolism; D000818:Animals; D003999:Dichloroacetic Acid / Q000494:pharmacology*; D004789:Enzyme Activation; D066298:In Vitro Techniques; D007651:Keto Acids / Q000037:antagonists & inhibitors / Q000378:metabolism; D007658:Ketone Oxidoreductases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D007930:Leucine / Q000378:metabolism*; D008297:Male; D008929:Mitochondria, Heart / Q000201:enzymology; D009097:Multienzyme Complexes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology*; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats
D000085:Acetates; D000597:Amino Acids, Branched-Chain; D007651:Keto Acids; D009097:Multienzyme Complexes; D003999:Dichloroacetic Acid; D007658:Ketone Oxidoreductases; D042942:3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide); D007930:Leucine