title: Hypothalamic hyperphagia and obesity in rats with jejunoileal bypass.
abstract: Jejunoileal bypass or sham surgery was performed in adult female rats followed 35 days later by ventromedial hypothalamic (VMH) knife cut or sham surgery (forming groups Bypass-VMH, Bypass-Sham, Sham-VMH, and Sham-Sham). Bypassed rats receiving VMH cuts (Bypass-VMH group) ate more food and gained more weight than did either Bypass-Sham or Sham-Sham groups. The hyperphagia and obesity of the Bypass-VMH rats was, however, substantially less than that of the sham bypass VMH cut rats (Sham-VMH group). Bypass-VMH rats that had their intestinal tract reconnected increased their food intake and ultimately became as obese as the Sham-VMH rats. Two additional groups received VMH knife cut or sham surgery followed 50 days later by jejunoileal bypass surgery (VMH-Bypass and Sham-Bypass groups). At the time of the bypass the VMH-Bypass group was hyperphagic and obese, but after surgery they underate and lost weight until they eventually stabilized their body weight at a level below that of the Sham-Bypass group. The body weight of the VMH-Bypass group was also 167 g less than that of the Bypass-VMH group. Thus, the order of surgery significantly influences the food intake and body weight level of rats with VMH knife cuts and jejunoileal bypass.
mesh_terms: D000818:Animals; D001835:Body Weight; D004327:Drinking Behavior / Q000502:physiology; D002149:Energy Intake; D005247:Feeding Behavior / Q000502:physiology*; D005260:Female; D007031:Hypothalamus / Q000502:physiology* / Q000601:surgery; D007082:Ileum / Q000601:surgery; D007583:Jejunum / Q000601:surgery; D009765:Obesity / Q000503:physiopathology*; D051381:Rats