Antithrombin III contribution to cholestasis differential diagnosis: its correlation with one stage prothrombin time and factor V.
Levels of antithrombin III (AT III) measured by two different methods, Factor V (FV) and One Stage Prothrombin Time, have been studied in two groups of patients: 55 with chronic liver disease and 22 with extra hepatic cholestasis. Results show a statistically significant correlation between the decrease of AT III and FV in the first group, and the normality of these parameters (unrelated to One Stage Prothrombin Time) in the second group. Levels at AT III and FV correlate directly with the functional integrity of hepatic parenchyma, so they may help in the differential diagnosis of different types of cholestasis.
D000990:Antithrombin III / Q000032:analysis*; D001651:Cholestasis, Extrahepatic / Q000097:blood / Q000175:diagnosis*; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005165:Factor V / Q000032:analysis*; D005260:Female; D006801:Humans; D008103:Liver Cirrhosis / Q000097:blood / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D011517:Prothrombin Time
D000990:Antithrombin III; D005165:Factor V