Mitogenic activity of staphylococcal exfoliative toxin.
Exfoliative toxin from Staphylococcus aureus was mitogenic for murine spleen cells. It was primarily active on T lymphocytes but also significantly stimulated B cells from the spleens of nude mice. The mitogenicity was not affected by simple sugar or alpha-methylpyranosides. N-acetylglucosamine and N-acetylgalactosamine inhibited its effect. Exfoliatin was as powerful a mitogen as the enterotoxins of S. aureus. Some significant differences between the mitogenic activity of the two toxins were demonstrated.
D000818:Animals; D001427:Bacterial Toxins / Q000494:pharmacology*; D002478:Cells, Cultured; D008213:Lymphocyte Activation / Q000187:drug effects*; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008819:Mice, Nude / Q000276:immunology; D008934:Mitogens; D013154:Spleen / Q000276:immunology; D013211:Staphylococcus aureus / Q000276:immunology*
D001427:Bacterial Toxins; D008934:Mitogens