The angiographic effect of ergonovine and nifedipine in coronary artery spasm.
In a patient with variant angina, we have shown that the calcium-channel blocker nifedipine inhibits both spontaneous and ergonivine-induced coronary artery spasm. It had no effect, however, on the dose-related diffuse vasoconstriction caused by ergonovine, suggesting two distinct responses of coronary arteries to ergonovine provocation. Nifedipine did not cause epicardial coronary artery dilatation, as did nitroglycerin, supporting the rationale of using both therapies together to treat coronary artery spasm.
D000328:Adult; D003331:Coronary Vessels / Q000503:physiopathology*; D004562:Electrocardiography; D004874:Ergonovine / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009543:Nifedipine / Q000627:therapeutic use*; D011725:Pyridines / Q000627:therapeutic use*; D011859:Radiography; D013035:Spasm / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy
D011725:Pyridines; D009543:Nifedipine; D004874:Ergonovine