Morphological study of cleft palate development in 5-fluorouracil-treated hamster fetuses.
Morphogenesis of palate was studied in normal and 5-fluorouracil-treated hamster fetuses. The results showed that normal palatal development was completed between days 12 and 13 of gestation. In 5-fluorouracil-assaulted palate the reorientation of shelves from a vertical to horizontal plane was delayed. Crown-rump length, gestational age and fetal weight were reliable predictors of the stages of normal palatal development, whereas the morphological rating system was not. Following 5-fluorouracil treatment, however, crown-rump length, weight and morphological rating were poor indicators of the stage of palatal development.
D000014:Abnormalities, Drug-Induced / Q000196:embryology*; D000818:Animals; D001699:Biometry; D002972:Cleft Palate / Q000139:chemically induced / Q000196:embryology*; D006224:Cricetinae; D005472:Fluorouracil / Q000633:toxicity*; D008647:Mesocricetus; D009024:Morphogenesis; D010159:Palate / Q000196:embryology; D013997:Time Factors
D005472:Fluorouracil