[Effect of monoamines on motoneurons of isolated rat spinal cord].
Superfusion of isolated hemisected spinal cord of 9-13 day old rats by solution containing noradrenaline induced de- or hyperpolarization of motoneurons depending on amine concentrations. Both effects resulted from a direct influence of amine upon motoneurons since they remained in the medium with abundance of Mg++ions and deficit of Ca++ions. Depolarization and hyperpolarization of motoneurons induced by noradrenaline was depressed by alpha-adrenoblockators. Depolarization of motoneurons induced by dopamine was suppressed in medium with abundance of Mg++ions. Hyperpolarization of motoneurons induced by dopamine was suppressed by haloperidol but remained unchanged under phentolamine. Depolarization of motoneurons induced by serotonin and its metabolities-mexamine, kynurenine and 3-oxyanthranilic acid-remained in the medium with abundance of Mg++ions and deficit of Ca++ions and was depressed by deseril and BAS. Hyperpolarization effect of serotonin appearing in some experiments under high concentration of serotonin (10(-4)-10(-3) M) was suppressed in medium with abundance of Mg++ions and in the presence of morphine.
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D003655:Decerebrate State; D004298:Dopamine / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology; D008564:Membrane Potentials / Q000187:drug effects; D009046:Motor Neurons / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology*; D051381:Rats; D012701:Serotonin / Q000494:pharmacology*; D013116:Spinal Cord / Q000187:drug effects*
D012701:Serotonin; D008274:Magnesium; D002118:Calcium; D004298:Dopamine; D009638:Norepinephrine
Vliianie monoaminov na motonĕirony izolirovannogo spinnogo mozga krysy.