Local mitogenic effect of tissue mast cell secretion.
The effect of drug-induced mast cell secretion on proliferation was studied in fibroblast-like and mesothelial-like cells in organ-cultured rat mesentery. Mast cell degranulation achieved by Compound 48/80 was followed by a marked mitogenic reaciton in the surrounding tissue cells. The drug itself lacked mitogenic effect on cultured guinea-pig mesentery, the mast cells of which are unresponsive to the drug, and on a human normal fibroblast-like cell line. In contrast, histamine at about 10-(10) M, a major mast cell component, induced marked mitogenesis in guinea-pig mesentery without causing degranulation of mast cells. It is concluded that secreting rat-tissue mast cells release a mitogenic factor or factors acting locally on nearby tissue cells.
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000502:physiology*; D008643:Mesentery / Q000166:cytology; D008934:Mitogens; D008938:Mitosis / Q000187:drug effects; D009924:Organ Culture Techniques; D051381:Rats; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology*
D008934:Mitogens; D003189:p-Methoxy-N-methylphenethylamine