Does the rodent model adequately predict the effects of ozone induced changes to human erythrocytes?
There is an important need to develop animal models to simulate the response of humans to environmental pollutants. The rodent model has been commonly employed to predict the effects of ambient ozone on human RBCs. The use of rodent models for such a purpose is questioned. This challenge is based on the a) ability of mice to significantly enhance ascorbic acid synthesis following ozone stress, b) the ability of ascorbic acid to prevent oxidant [i.e. acetylphenylhydrazine (APH)] stress to human G-6-PD deficient RBCs and c) the lack of ability of humans to synthesize ascorbic acid.
D000818:Animals; D001205:Ascorbic Acid / Q000097:blood; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000187:drug effects*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood; D006801:Humans; D010126:Ozone / Q000633:toxicity*; D051381:Rats
D010126:Ozone; D001205:Ascorbic Acid