[Influence of  nonachlazin, riboxin and isoptin on the blood coagulation system and the anticoagulant effect of heparin].
Nonachlazin binds in vitro heparin in blood plasma and aqueous medium. This interaction complies with logarithmic dependence. Isoptin increases in vitro plasma susceptibility to heparin, reduces the period of whole blood coagulation and thrombin time. Riboxin does not produce in vitro any effect on the blood coagulation parameters and heparin susceptibility. Single and chronic adminstration of the drugs exerts no effect on blood coagulation. Prolonged use of riboxin promotes the increased level of endogenous heparin. Both single and chronic administration of the drugs potentiates the anticoagulant action of heparin.
D000818:Animals; D000925:Anticoagulants / Q000037:antagonists & inhibitors*; D001777:Blood Coagulation / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology*; D006494:Heparin Antagonists; D066298:In Vitro Techniques; D007290:Inosine Diphosphate / Q000494:pharmacology*; D007292:Inosine Nucleotides / Q000494:pharmacology*; D008297:Male; D009628:Nonachlazine / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology*; D011817:Rabbits; D013997:Time Factors; D014700:Verapamil / Q000494:pharmacology*
D000925:Anticoagulants; D006494:Heparin Antagonists; D007292:Inosine Nucleotides; D010640:Phenothiazines; D009628:Nonachlazine; D007290:Inosine Diphosphate; D006493:Heparin; D014700:Verapamil
Vliianie nonakhlazina, riboksina i izoptina na sistemu svertyvaniia krovi i antikoaguliantnyĭ éffekt geparina.