The effect of prostaglandin E2 microinjected into the rat hypothalamus on urinary excretion of water and sodium.
1 Effects of prostaglandin E2 (PGE2) microinjected into the supraoptic (SON) and the ventromedial nuclei of the hypothalamus (VMH) on urine outflow were studied in rats anaesthetized with ethanol. 2 PGE2 injected into the SON caused antidiuresis and increased the excretion rate of Na+. These effects of PGE2 were prevented by pretreatment with phentolamine but not propranolol, suggesting that they are mediated by alpha-adrenoceptors in the SON. 3 PGE2 injected into the VMH caused diuresis and increased the excretion rate of Na+. These effects were prevented by pretreatment with propranolol but not phentolamine, suggesting that they are mediated through beta-adrenoceptors in the VMH.
D000818:Animals; D004231:Diuresis / Q000187:drug effects*; D007031:Hypothalamus / Q000187:drug effects*; D007267:Injections; D008297:Male; D009318:Natriuresis / Q000187:drug effects*; D011458:Prostaglandins E / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D011458:Prostaglandins E