title: Serous cysts of the aging guinea pig ovary. III. Permeability of the cyst epithelium to lanthanum and horseradish peroxidase.
abstract: The permeability of the epithelium lining serous cysts of the guinea pig ovary was examined using lanthanum and horseradish peroxidase (HRP). Both lanthanum and HRP introduced at the luminal surface of the cyst penetrated to the basal region filling caveolae in both lateral and basal cell surfaces. Within three minutes of vascular infusion of HRP, the tracer was detected between epithelial cells and in caveolae on their lateral and basal surfaces but not associated with intracellular organelles. There was no change in the intracellular distribution of HRP after ten minutes. It was concluded that the epithelium was permeable to the tracers within this time period but that pinocytosis and transport of these tracers through the epithelial cell were not demonstrated.
mesh_terms: D000375:Aging; D000818:Animals; D004848:Epithelium / Q000503:physiopathology / Q000648:ultrastructure; D005260:Female; D006735:Horseradish Peroxidase / Q000378:metabolism; D007811:Lanthanum / Q000378:metabolism; D010048:Ovarian Cysts / Q000473:pathology / Q000503:physiopathology*; D010539:Permeability
chemical_list: D007811:Lanthanum; D006735:Horseradish Peroxidase