Irreversible active-site-directed inhibition of delta 5-3-ketosteroid isomerase by steroidal 17-beta-oxiranes. Evidence for two modes of binding in steroid-enzyme complexes.
D015068:17-Ketosteroids / Q000494:pharmacology*; D004852:Epoxy Compounds / Q000494:pharmacology; D007535:Isomerases / Q000037:antagonists & inhibitors*; D007700:Kinetics; D011549:Pseudomonas / Q000201:enzymology*; D013050:Spectrometry, Fluorescence; D013141:Spiro Compounds / Q000494:pharmacology; D013251:Steroid Isomerases / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D015068:17-Ketosteroids; D004852:Epoxy Compounds; D013141:Spiro Compounds; D007535:Isomerases; D013251:Steroid Isomerases; C022660:steroid delta-isomerase