title: Angiotensin II dependency of vascular resistance in the untouched kidney of renal hypertensive rats.
abstract: Renal hemodynamics following administration of the angiotensin II antagonist Saralasin were studied in untouched kidney of 11 two-kidney hypertensive rats and in kidneys of 7 control rats using an electromagnetic flowmeter. Renal blood flow (RBF) in controls averaged 6.2 +/- (SD) 1.7 vs. 5.2 +/- 0.9 ml/min/g kidney weight in the hypertensive group (n.s.). Renal vascular resistance (RVR) was significantly increased in untouched kidneys: 2.6 +/- 0.5 vs. 1.8 +/- 0.4 dyn .  sec . cm-5 . 10(6) . g kidney weight-1. Following Saralasin infusion mean arterial blood pressure decreased significantly more in hypertensive rats. RBF increased by 24% in untouched kidneys vs. 12% in controls (p < 0.05), indicating a 34% decrease of RVR in hypertensive rats vs. 18% (p < 0.005) in controls. These results indicate that the increased RVR in untouched kidneys is highly dependent on circulating angiotensin II, which may reduce the antihypertensive role of the untouched kidney.
mesh_terms: D000804:Angiotensin II / Q000502:physiology*; D000818:Animals; D001794:Blood Pressure; D006439:Hemodynamics / Q000187:drug effects; D006977:Hypertension, Renal / Q000503:physiopathology*; D007668:Kidney / Q000098:blood supply / Q000503:physiopathology*; D008297:Male; D051381:Rats; D012039:Regional Blood Flow; D012504:Saralasin / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D000804:Angiotensin II; D012504:Saralasin