title: Modal DNA content of human intracranial neoplasms studied by flow cytometry.
abstract: The relative DNA content in 56 human intracranial tumors was investigated by flow cytometry and correlated to their histological type. Tumors with a modal DNA content within the diploid value (2c) +/- 1/2c were divided from those with heteroploidy. Of the "benign non-neuroepithelial tumors," the meningiomas (five), neurilemomas (two), pituitary adenomas (three), and one hemangioblastoma had a unimodal diploid/near-diploid DNA content. The "malignant non-neuroepithelial tumors" were both heteroploid (two metastatic carcinomas) and diploid/near-diploid (three meningeal fibrosarcomas and one primary malignant lymphoma). Of the neuroepithelial tumors, the highly differentiated gliomas all had a diploid/near-diploid DNA mode except one recurrent oligodendroglioma. The majority of the poorly differentiated gliomas also presented near-diploid DNA modes. Heteroploidy of primary brain tumors was not correlated with a more malignant clinical/biological behavior in the individuals in this study.
mesh_terms: D000236:Adenoma / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000378:metabolism* / Q000401:mortality / Q000556:secondary; D002648:Child; D002675:Child, Preschool; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D005910:Glioma / Q000378:metabolism*; D006651:Histocytochemistry / Q000379:methods; D006801:Humans; D007223:Infant; D008297:Male; D008579:Meningioma / Q000378:metabolism; D008875:Middle Aged; D009442:Neurilemmoma / Q000378:metabolism; D010911:Pituitary Neoplasms / Q000378:metabolism; D013050:Spectrometry, Fluorescence
chemical_list: D004273:DNA, Neoplasm