title: Modifications of biochemical parameters in blood platelets of schizophrenic and depressive patients.
abstract: The blood platelet may be considered as an interesting model of the serotoninergic neuron in biology and pharmacology. We studied some platelet parameters in neuropsychiatric patients (depressive and schizophrenic ones): serotonin (5-HT) uptake was abnormal for all schizophrenics and lowered for depressive patients; uptake of mepacrine, a marker of 5-HT passive diffusion, was diminished for manic patients; MAO and glutathione peroxidase activities were modified, essentially for paranoid schizophrenics and some alterations of the platelet hydroxyindole level were noticed; during treatment with neuroleptics of antidepressants biological parameters led to 'normality'. These results are discussed with clinical data and a hypothesis is proposed to join the biological modifications of paranoid schizophrenics.
mesh_terms: D001792:Blood Platelets / Q000201:enzymology / Q000378:metabolism*; D003863:Depression / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006801:Humans; D010544:Peroxidases / Q000378:metabolism*; D011796:Quinacrine / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*; D012701:Serotonin / Q000378:metabolism
chemical_list: D012701:Serotonin; D010544:Peroxidases; D005979:Glutathione Peroxidase; D011796:Quinacrine