title: Characterization of mutagenic principles and carcinogenicity of dill weed and seeds.
abstract: Among the various kinds of spices tested, the aqueous extracts of dill weed from Anethum graveolens L. and dill seeds from A. sowa D.C. (Umbelliferae), exhibited a mutagenicity to Salmonella typhimurium, strains TA98 and TA100. The aqueous methanol extracts were fractionated by the mutation assay using the strain TA98 with S-9 Mix. Isorhamnetin 3-sulfate (persicarin) and quercetin 3-sulfate were characterized as the mutagenic principles. Carcinogenicity was not observed for dill weed and seeds when the diets containing these in 33% were administered for 450 and 410 days, respectively, to the inbred strain ACI rats.
mesh_terms: D000818:Animals; D002273:Carcinogens / Q000032:analysis*; D003212:Condiments / Q000032:analysis*; D005260:Female; D005419:Flavonoids / Q000032:analysis; D006868:Hydrolysis; D008297:Male; D009152:Mutagenicity Tests; D009153:Mutagens / Q000032:analysis*; D011794:Quercetin / Q000032:analysis; D051381:Rats; D012639:Seeds / Q000032:analysis
chemical_list: D002273:Carcinogens; D005419:Flavonoids; D009153:Mutagens; D011794:Quercetin