[Effect of coronary blood flow recovery after its measured limitation on the hemodynamics and contractile capacity of the myocardium].
Dosaged restriction of coronary blood flow and its subsequent restoration were conducted in acute experiments on anesthesized dogs under conditions of closed chest and preserved natural respiration. The degree of ischemic damage to the heart muscle was determined by means of precardial ECG, the functional condition of the left ventricle was studied according to the data on intraventricular pressure and the rate of its changes with subsequent calculation of the contractility indices. The indices of general hemodynamics were also studied. A definite correlation between the blood supply and function of the myocardium was established. It is shown that temporary restriction of coronary blood flow by 50 and 80% leads to subsequent long-term changes in the functional condition of the heart muscle and general hemodynamics.
D000818:Animals; D001794:Blood Pressure; D003326:Coronary Circulation; D003327:Coronary Disease / Q000503:physiopathology*; D004285:Dogs; D004562:Electrocardiography; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006439:Hemodynamics; D008297:Male; D009200:Myocardial Contraction; D013997:Time Factors
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