ADP induced surface charge changes of adult and newborn platelets.
In experiments reported here electrophoretic mobility of washed platelets and platelets suspended in diluted plasma obtained from adults and newborns was practically the same. No significant difference was observed in the pH-mobility relationship of the two types of platelets. These comparative studies indicate that the actual charge density, i.e. the number and sign of the charged groups at the newborn and adult platelet surfaces are essentially identical. However, a significant difference was found between the two platelet populations in the mobility changes induced by ADP. On the basis of cross over experiments between the platelets and plasma of adults and newborns it seems likely that the different behaviour of neonatal platelets arises from a difference between adult and newborn plasma. Preliminary results indicate that this may be due to the presence in adult plasma of a component with molecular weight about 10 000.
D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000328:Adult; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D004586:Electrophoresis; D005312:Fetal Blood / Q000502:physiology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D008564:Membrane Potentials / Q000187:drug effects
D000244:Adenosine Diphosphate