title: Highly structured water network in crystals of a deoxydinucleoside---drug complex.
abstract: X-ray diffraction analysis of crystals of the intercalative complex between the deoxyribonucleoside phosphate d(CpG) and the mutagen proflavine shows a highly structured arrangement of water molecules linked together by newtworks of hydrogen bonds to form four edge-linked pentagons per asymmetric unit. These pentagons have a general role in maximizing hydrogen bonding at 3.4-A intervals. The conformation of the deoxyribose sugar ring at the 3' end of one strand can depend on its local aqueous environment.
mesh_terms: D000166:Acridines; D003461:Crystallography; D006860:Hydrogen Bonding; D008968:Molecular Conformation; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D011370:Proflavine; D014867:Water; D014961:X-Ray Diffraction
chemical_list: D000166:Acridines; D009838:Oligodeoxyribonucleotides; D009841:Oligonucleotides; D014867:Water; D011370:Proflavine