[Effect of acetylsalicylic acid and pentoxifylline (trental) on intravascular erythrocyte aggregation stimulated by arachidonic acid].
The role of arachidonic acid (3--5 mg/kg animal body weight) in the intravascular red cell aggregation was studied on rats by intravital microscopy. It has been established that intravenous injection of arachidonic acid leads to aggregation and red cell hemolysis, and animals' death. Preliminary injection of acetylsalicylic acid or pentoxyphylline prevents the initiation of aggregation and lysis of red cells but does not avert the animals' death because of arachidonic acid. It is concluded that arachidonic acid plays an important role in aggregation and lysis of red cells. It is recommended that reasons for animals' death because of arachidonic acid in the absence of microcirculatory disorders be studied.
D000818:Animals; D001095:Arachidonic Acids / Q000037:antagonists & inhibitors* / Q000506:poisoning; D001241:Aspirin / Q000494:pharmacology*; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D006461:Hemolysis / Q000187:drug effects; D066298:In Vitro Techniques; D010431:Pentoxifylline / Q000494:pharmacology*; D051381:Rats; D013805:Theobromine / Q000031:analogs & derivatives*
D001095:Arachidonic Acids; D013805:Theobromine; D001241:Aspirin; D010431:Pentoxifylline
Vliianie atsetilsalitsilovoĭ kisloty i pentoksifillina (trentala) na vnutrisosudistuiu agregatsiiu éritrotsitov, stimulirovannuiu arakhidonovoĭ kislotoĭ.