Polymorphic acetylation of sulphamethazine in man: acetylator phenotype in sicklers and non-sicklers.
The acetylator phenotype was determined for 183 Nigerians after administration of sulphamethazine at a dose level of 40 mg/kg body weight and analysis of urine after 6 h. Haemoglobin electrophoresis showed that 63 people (34.4%) carried the sickle cell trait. The % of slow acetylators amongst sicklers was 39.7 and amongst non-sicklers 40.8, a difference that was not significant.
D000107:Acetylation; D000328:Adult; D000755:Anemia, Sickle Cell / Q000378:metabolism*; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D009549:Nigeria; D010641:Phenotype; D012805:Sickle Cell Trait / Q000378:metabolism*; D013418:Sulfamethazine / Q000378:metabolism*
D006454:Hemoglobins; D013418:Sulfamethazine