Interaction of calcium and potassium with neuromuscular blocking agents.
Dose-response curves for blockade of the indirectly elicited twitch of isolated guineapig nerve-lumbrical muscle preparations were determined for tubocurarine and pancuronium in the presence of potassium 2,4 and 6 mmol litre-1 and calcium 1,2 and 3 mmol litre-1. Increases in concentration of either ion decreased the sensitivity of the preparation to both drugs. Over the physiological range of concentrations of potassium and calcium, 36% and 27% variation in dosage can be expected.
D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009469:Neuromuscular Junction / Q000187:drug effects*; D010197:Pancuronium / Q000494:pharmacology*; D011188:Potassium / Q000494:pharmacology*; D014403:Tubocurarine / Q000494:pharmacology*
D010197:Pancuronium; D011188:Potassium; D002118:Calcium; D014403:Tubocurarine