title: Failure of indomethacin to prevent or ameliorate oleic acid pulmonary edema in the dog.
abstract: The possibility that prostaglandin synthesis inhibition might favorably inhibit the development of animal adult respiratory distress syndrome models was investigated in two groups of dogs; one group was pretreated with indomethacin 3 mg/kg. Both groups received oleic acid 0.15 mg/kg. Measurements of gas exchange and hemodynamics were performed every hour for 5 hours following embolization. Severe pulmonary edema developed in both groups. The indomethacin pretreated group responded similarly to the control group; there was no difference in the 5 hour course of Pa02 (p = .34), P(A-a)02 (p = .21) or QS/QT (p = .99). Prostaglandin synthesis inhibition did not favorably influence the immediate development of acute respiratory failure following oleic acid.
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D007213:Indomethacin / Q000627:therapeutic use*; D009829:Oleic Acids / Q000494:pharmacology; D011453:Prostaglandins / Q000378:metabolism; D011654:Pulmonary Edema / Q000139:chemically induced / Q000188:drug therapy*; D012128:Respiratory Distress Syndrome / Q000188:drug therapy
chemical_list: D009829:Oleic Acids; D011453:Prostaglandins; D007213:Indomethacin