Effect of phalloidin on platelet aggregation.
By the addition of phalloidin, an oligopeptide of Amanita phalloides, to platelet-rich plasma, an increase of its transparency could be observed. The rate of increase of transparency was slow but the maximal intensity corresponded to that of ADP aggregation. Morphologically, many microfilaments were formed in the cytoplasm. But the figures were different from those in platelets in ADP aggregation.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D001792:Blood Platelets / Q000648:ultrastructure; D003571:Cytochalasin B / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology*; D010590:Phalloidine / Q000494:pharmacology*; D010974:Platelet Aggregation / Q000187:drug effects*
D009842:Oligopeptides; D010590:Phalloidine; D003571:Cytochalasin B; D000244:Adenosine Diphosphate