Histamine increases histidine uptake by basophils.
Histamine, at high concentrations, enhanced the uptake of isotopic histidine by guinea-pig basophils. The effect was partially reversed by H1-, but not H2-, histamine receptor antagonists. These data suggest that histamine has a bioregulatory role in its own synthesis.
D000818:Animals; D001491:Basophils / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology*; D006633:Histamine Antagonists / Q000494:pharmacology; D006639:Histidine / Q000378:metabolism*; D066298:In Vitro Techniques; D013268:Stimulation, Chemical
D006633:Histamine Antagonists; D006639:Histidine; D006632:Histamine