Relationship between sleep deprivation and urinary MHPG levels.
A 5-day study, forming the initial part of two 32-day clinical trials and involving 22 unipolar depressed inpatients, was designed to determine the relationship between response to sleep deprivation and 24-hour urinary MHPG levels. A statistically significant, positive relationship was noted between the sleep deprivation, modified total HAM-D scores and MHPG levels at postsleep deprivation, indicating that the greater the severity of depression during sleep deprivation the higher were the MHPG levels after the sleep deprivation period.
D000328:Adult; D003863:Depression / Q000652:urine; D005260:Female; D006018:Glycols / Q000652:urine*; D006801:Humans; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D008875:Middle Aged; D012892:Sleep Deprivation
D006018:Glycols; D008734:Methoxyhydroxyphenylglycol