The metabolism of 3-phenoxybenzoic acid and its glucoside conjugate in rats.
1. 3-Phenoxy[14C]benzoic acid administered orally to rats (0.76 to > 100 mg/kg) is extensively metabolized and rapidly eliminated mostly via the urine. 2. The major metabolic pathway involves 4'-hydroxylation followed by conjugation of the resulting phenol with sulphate. Only minor amounts of amino acid and glucuronic acid conjugation were observed. 3. 3-Phenoxy[14C]benzoyl glucoside, derived from the metabolism of the acid by corn leaves, was also rapidly absorbed by rats and eliminated as a mixture of metabolites very similar to that derived from 3-phenoxybenzoic acid. It was concluded that the glucoside conjugate was rapidly hydrolysed to the free acid in vivo.
D000818:Animals; D001565:Benzoates / Q000378:metabolism* / Q000652:urine; D005243:Feces / Q000032:analysis; D005260:Female; D005960:Glucosides / Q000378:metabolism; D006900:Hydroxylation; D008297:Male; D010647:Phenyl Ethers / Q000378:metabolism* / Q000652:urine; D051381:Rats; D012737:Sex Factors
D001565:Benzoates; D005960:Glucosides; D010647:Phenyl Ethers; C017618:3-phenoxybenzoic acid