Reversal of microvascular abnormalities in a successfully treated case of leukocytoclastic vasculitis.
A patient with leukocytoclastic vasculitis was successfully treated by chemotherapy. While his symptoms and serologic abnormalities cleared, his abnormal interendothelial junctions decreased from 36% to 8% (p < 0.01), and the vessels showing deposits of electron-dense material decreased from 75% to 10% (p < 0.001). These data are consistent with the hypothesis that deposition of electron-dense material (probable immune complex) in the subendothelium of the dermal microcirculation is intimately involved in the pathogenesis of this form of nonthrombocytopenic purpura.
D000936:Antigen-Antibody Complex; D003520:Cyclophosphamide / Q000627:therapeutic use; D006801:Humans; D007365:Intercellular Junctions / Q000648:ultrastructure; D007962:Leukocytes / Q000648:ultrastructure*; D008297:Male; D008833:Microcirculation / Q000648:ultrastructure*; D008875:Middle Aged; D011241:Prednisone / Q000627:therapeutic use; D011693:Purpura / Q000188:drug therapy / Q000473:pathology*; D012867:Skin / Q000098:blood supply; D014657:Vasculitis / Q000188:drug therapy / Q000473:pathology*; D014750:Vincristine / Q000627:therapeutic use
D000936:Antigen-Antibody Complex; D014750:Vincristine; D003520:Cyclophosphamide; D011241:Prednisone