Degradation of chlorambucil in aqueous solution.
The stability of chlorambucil and its degradation product 4-[p-(2-chloroethyl-2-hydroxyethylamino)phenyl]butyric acid (I) was studied using reversed-phase high-pressure liquid chromatography. The degradation rate of chlorambucil was unaffected by pH between pH 5 and 10 but decreased at lower pH. The degradation rates of chlorambucil and I differed only slightly (pH < 6). The proteolytic properties of the compounds were studied using spectrophotometric and partition techniques.
D055598:Chemical Phenomena; D002621:Chemistry; D002699:Chlorambucil / Q000032:analysis*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D012996:Solutions
D012996:Solutions; D002699:Chlorambucil