Sex differences in age- and atherosclerosis-related changes of human coronary arteries.
A study carried out on the coronary arteries of 536 subjects ranging in age from 0 to 40 years demonostrated that males exhibited, as compared to females of similar age: more numerous and extensive severe changes of the internal elastic membrane, particularly in neonates and children; a thicker intimal layer in all age-groups investigated; an earlier development of atherosclerotic plaques and of atheroma-like lesions; a higher number of cases with coronary atherosclerotic plaques; a more precocious and diffuse extension of atherosclerotic plaques in the whole coronary tree.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001161:Arteriosclerosis / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D003327:Coronary Disease / Q000473:pathology*; D003331:Coronary Vessels / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D012737:Sex Factors