A comparison of the in vivo uptake of [3H]GABA into rat celebral cortex and dorsal medulla following topical application.
The penetration of [3H]GABA and [14C]sucrose from the dorsal surface of the rat medulla and cerebral cortex was studied in vivo. The levels of both declined exponentially from the surface of both regions and were decreased by raised potassium levels and the presence of GABA uptake inhibitors. Inhibition of GABA metabolism increased the amounts of 3H recovered particularly after long incubation periods. More [3H]GABA and [14C]sucrose was tken up into the cerebral cortex than the medulla, and more [3H]GABA than [14C]sucrose was taken up in both regions.
D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism*; D008526:Medulla Oblongata / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D051381:Rats; D013003:Somatosensory Cortex / Q000378:metabolism; D013395:Sucrose / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D005680:gamma-Aminobutyric Acid; D013395:Sucrose