Excretion of dietary butylated hydroxytoluene by the rat.
The concentration of phenols in the urine or feces of rats receiving a diet containing 1.00% butylated hydroxytoluene (BHT) for 10 days was determined colorimetrically. The cumulative intake of BHT was approx. 5.0 mmol/rat for 10 days. The total amount of phenols excreted in urine and feces was 3.65 mmol/rat for 10 days, i.e. 73% of the administered BHT. About 48% was excreted in the urine, and 25% in the feces; about 30%, or 11%, of the dose appeared to be present as unconjugated phenols in the urine, or feces, respectively. The major metabolite detected was 3,5-di-tert-butyl-4-hydroxybenzoic acid (BHT acid).
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002084:Butylated Hydroxytoluene / Q000378:metabolism* / Q000633:toxicity; D004032:Diet; D006470:Hemorrhage / Q000139:chemically induced; D008297:Male; D010636:Phenols / Q000378:metabolism; D051381:Rats
D010636:Phenols; D002084:Butylated Hydroxytoluene