[Effect of fenformin on the blastomogenic action of 1,2-dimethylhydrazine in rats].
Weekly administrations of SDMH to female rats were shown to decrease the tolerance to glucose loading, to increase the cholesterol, triglyceride and insulin levels in serum. Antidiabetic biguanide phenoformin decreases the multiplicity of SDMH-induced colon cancers and decreases their mean square value. The normalizing influence of phenoformin on the cancrophilia syndrome is suggested to be the main factor of its antitumor effect
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002784:Cholesterol / Q000097:blood; D004127:Dimethylhydrazines / Q000494:pharmacology*; D004347:Drug Interactions; D005260:Female; D008763:Methylhydrazines / Q000494:pharmacology*; D009374:Neoplasms, Experimental / Q000097:blood / Q000139:chemically induced*; D010629:Phenformin / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D004127:Dimethylhydrazines; D008763:Methylhydrazines; D014280:Triglycerides; D002784:Cholesterol; D010629:Phenformin
Vliianie fenformina na blastomogennyĭ éffekt 1,2-dimetilgidrazina u krys.