Bile salt transport in the Dubin-Johnson syndrome.
Serum bile salt measurements and intravenous clearance of glycocholate were performed in a woman with Dubin-Johnson syndrome. Fasting conjugated cholate concentration was raised and prolonged intravenous clearance of sodium glycocholate revealed a secondary rise in conjugated cholate concentration after two hours. The intravenous clearance of bromsulphthalein also showed a secondary rise. These findings support the proposal that Dubin-Johnson syndrome is not homogeneous and that in some patients a abnormality of bile salt clearance coexists with an abnormality of bilirubin nd bromsulphthalein clearance.
D000368:Aged; D002793:Cholic Acids / Q000097:blood*; D005260:Female; D006000:Glycocholic Acid; D006801:Humans; D007566:Jaundice, Chronic Idiopathic / Q000097:blood*; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D013448:Sulfobromophthalein
D002793:Cholic Acids; D013448:Sulfobromophthalein; D006000:Glycocholic Acid