[Acid reduction after SPV and after H2 receptor blocking substance cimetidine. Comparative studies in Shay-rats)].
The effect of a complete selective proximal vagotomy on stomach acidity has been compared experimentally to that of the H2 receptor blocking agent cimetidine in the rat. Both methods produced a significant reduction of total acid as compared to controls, a reduction to 0.5 % for cimetidine and to 0.1 % for SPV. The acid reduction following SPV is a result of decreased production of stomach fluid as well as a decrease in degree of acidity. The acid reduction following administration of cimetidine is mainly a result of an increase in pH without any change in volume of stomach fluid production.
D000818:Animals; D002927:Cimetidine / Q000494:pharmacology*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000187:drug effects / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology*; D008297:Male; D011708:Pylorus / Q000601:surgery; D051381:Rats; D014628:Vagotomy / Q000379:methods*
D006146:Guanidines; D002927:Cimetidine
Säurereduktion nach SPV und nach H2-Rezeptoren-Blockade. Vergleichsstudie an der Shay-Ratte.