Biosynthesis and accumulation of cadaverine and putrescine in rat ovary after administration of human chorionic gonadotrophin.
In the ovaries of pre-pubertal rats stimulated by human chorionic gonadotrophin (hCG) the temporal changes in cadaverine and putrescine formation were investigated. In addition, the dose-response relationship of hCG and its effect on the diamine formation and the effect of hCG on the content of diamines and polyamines in the ovaries and the urine were studied. The results show that the ovary stimulated by hCG, in addition to putrescine, forms cadaverine at a highly increased rate. The elevated diamine formation was parallelled by an increased content of cadaverine and putrescine in the ovary. Treatment with aminoguanidine elevated the content of cadaverine in the ovary, suggesting that diamine oxidase has a role as a regulator of the intra-ovary level of cadaverine. These results confirm that cadaverine can be synthesized in an inducible manner in mammalian tissues. This is, virtually, the first report of elevated formation of cadaverine in response to an exogenous gonadotrophin.
D000818:Animals; D002103:Cadaverine / Q000096:biosynthesis* / Q000378:metabolism; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D003959:Diamines / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D005260:Female; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D011700:Putrescine / Q000096:biosynthesis* / Q000378:metabolism; D051381:Rats; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000378:metabolism
D006063:Chorionic Gonadotropin; D003959:Diamines; D013096:Spermine; D002103:Cadaverine; D013095:Spermidine; D011700:Putrescine