Production of a new aminoglycoside antibiotic by a mutant of Bacillus circulans.
A new aminoglycoside antibiotic, S-11-A, was isolated from the fermentation broth of the 2-deoxystreptamine negative (DOS-) mutant of Bacillus circulans S-11. The structure of S-11-A was elucidated as 1-deamino-1-hydroxyxylostasin, which contains an intermediate of DOS biosynthesis (S-11-P) and has resistance to some aminoglycoside-inactivating enzymes. This is the first finding of antibiotic production by a DOS- mutant without any supplementation of DOS or a DOS analog, and could be described as a novel method of getting a new aminoglycoside antibiotic.
D000617:Aminoglycosides / Q000096:biosynthesis; D000900:Anti-Bacterial Agents / Q000096:biosynthesis*; D001407:Bacillus / Q000235:genetics / Q000378:metabolism*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D009682:Magnetic Resonance Spectroscopy; D009154:Mutation
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; C027406:1-deamino-1-hydroxyxylostasin