Effects of lead on movement of albumin into brain.
The offspring of CD-1 mice were exposed either to 0.5% sodium acetate or lead acetate in the drinking water from the time of birth. After weaning, locomotor activity was evaluated. The lead-exposed mice were hyperactive and smaller than the sodium-exposed mice. Methylphenidate, caffeine, ephedrine and pemoline all caused an increase in the movement of radioiodinated serum albumin (RISA) into the brain of sodium-exposed mice. In the lead-exposed animals the movement of RISA into the brain was decreased in the mice given saline (control), amphetamine, methylphenidate or ephedrine relative to the corresponding sodium-exposed animals. These changes are opposite to those previously found using radioactive pertechnetate as the probe of the function of the blood-brain barrier (BBB). This provides further evidence for the selectivity of the BBB in handling different types of molecules.
D000418:Albumins / Q000378:metabolism*; D000818:Animals; D001724:Birth Weight / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D005260:Female; D007854:Lead / Q000494:pharmacology*; D051379:Mice; D011247:Pregnancy; D012711:Serum Albumin, Radio-Iodinated / Q000378:metabolism
D000418:Albumins; D012711:Serum Albumin, Radio-Iodinated; D007854:Lead