Effect of intravenous corynebacterium parvum on peripheral-blood effector cells of cancer patients.
The i.v. administration of Corynebacterium parvum (CP) to patients who had recently undergone resection of colorectal tumours was found to have the following effects: 1. Polymorphonuclear leucocyte counts were raised 24 h after CP administration, while both lymphocyte and monocyte counts fell during this period. Polymorph and lymphocyte counts had returned to pre-infusion levels at one week, but monocyte counts were significantly increased at this time. 2. The lymphocyte mitotic response to PHA was reduced during the 24 h after CP infusion. 3 The spontaneous, antibody-induced, and PHA-induced lymphocyte-mediated cytotoxicity against a nucleated target cell fell significantly 3 h after CP infusion, but these functions recovered by 7 days. 4. A rise in serum lysozyme was found 3 and 24 h after CP administration. However, these increased levels were not maintained beyond 24 h.
D003602:Cytotoxicity, Immunologic; D006801:Humans; D007958:Leukocyte Count; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*; D009113:Muramidase / Q000097:blood; D010835:Phytohemagglutinins / Q000494:pharmacology; D011425:Propionibacterium acnes / Q000276:immunology*; D012004:Rectal Neoplasms / Q000276:immunology*
D010835:Phytohemagglutinins; D009113:Muramidase