title: The metabolism of some food additives related to piperonal in the rabbit.
abstract: 1. The metabolism of piperonylidene acetone, and the food additives piperonyl acetone, piperonyl acetate and piperonyl isobutyrate were studied in male rabbits after oral doses of 100 mg/kg. 2. Both piperonylidene acetone and piperonyl acetone were extensively excreted as 4-(3,4-methylenedioxyphenyl)-butan-2-ol to the extent of 71.5% and 81.5% dose respectively in the three-day urine. 3. The esters, piperonyl acetate and piperonyl isobutyrate, were both metabolized to piperonylic acid, to the extent of 70.5% and 11.4% of dose respectively, in the three-day urine.
mesh_terms: D000818:Animals; D001547:Benzaldehydes / Q000378:metabolism*; D052117:Benzodioxoles; D004149:Dioxoles / Q000378:metabolism*; D005503:Food Additives / Q000378:metabolism*; D008297:Male; D011817:Rabbits
chemical_list: D001547:Benzaldehydes; D052117:Benzodioxoles; D004149:Dioxoles; D005503:Food Additives; C026426:piperonyl acetate; C026424:piperonylidene acetone; C005454:piperonal; C026425:piperonyl acetone; C026427:piperonyl isobutyrate