Effect of sodium fluoride on collagen content in skin and lungs of growing rats.
Adult rats were given water with sodium fluoride (10 mg/l) during 7 weeks before pregnancy, during pregnancy and after the delivery. The born rats were treated in the same manner and were investigated 1, 2, 4 and 6 months after birth. It was found that exposure to sodium fluoride stimulated an increase of hydroxyproline and hydroxylysine concentration in serum and the urinary excretion of these catabolites. A decrease of soluble and insoluble collagen was shown in skin and lungs of exposed animals as compared with controls. The decrease of collagen in tissues was not age-dependent.
D000375:Aging; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D005459:Fluorides / Q000494:pharmacology*; D006901:Hydroxylysine / Q000097:blood / Q000652:urine; D006909:Hydroxyproline / Q000097:blood / Q000652:urine; D008168:Lung / Q000378:metabolism*; D051381:Rats; D012867:Skin / Q000378:metabolism*; D012969:Sodium Fluoride / Q000494:pharmacology*; D014881:Water Supply
D006901:Hydroxylysine; D012969:Sodium Fluoride; D003094:Collagen; D005459:Fluorides; D006909:Hydroxyproline