title: [Effect of ADT vaccine on children's nonspecific resistance to influenza and acute respiratory diseases when administered at different times before an outbreak of influenza].
abstract: The planned immunization of children aged 11 years with adsorbed DT vaccine in the years of influenza epidemics produced changes in unspecific resistance, occurring in phases: a decrease at the early postvaccinal period and an increase at the late postvaccinal period. When immunization was carried out, on the average, 10 days before the outbreak of influenza, the increased susceptibility phase coincided with the outbreak of influenza; as a reuslt, morbidity rate among the vaccinated children was 3 times higher than among the nonvaccinated children (P < 0.05). In children vaccinated, on the average, 30 days before the epidemic rise of influenza morbidity the increased resistance phase coincided with the peak of the epidemic outbreak; such children showed morbidity rate 6 times lower than the children in the control group. Planned immunization with adsorbed DT vaccine at definite seasons is proposed.
mesh_terms: D002648:Child; D004168:Diphtheria Toxoid / Q000008:administration & dosage*; D004196:Disease Outbreaks / Q000517:prevention & control; D005260:Female; D006801:Humans; D007251:Influenza, Human / Q000517:prevention & control*; D008297:Male; D012141:Respiratory Tract Infections / Q000517:prevention & control*; D013745:Tetanus Toxoid / Q000008:administration & dosage*; D013997:Time Factors; D014611:Vaccination
chemical_list: D004168:Diphtheria Toxoid; D013745:Tetanus Toxoid
vernacular_title: Vliianie ADs-vaktsiny na nespetsificheskuiu rezistentnost' detskogo organizma k grippu i ostrym respiratornym zabolevaniiam pri vvedenii ee v raznye sroki do vspyshki grippa.