Lymphocytotoxic antibodies in patients receiving granulocyte transfusions.
The presence of lymphocytotoxic antibodies was studied in 22 patients receiving granulocyte transfusions. Due to previous blood transfusions 7 out of 22 patients had lymphocytotoxic antibodies before granulocyte transfusions were started. 6 out of 15 unsensitized patients developed antibodies during granulocyte transfusion therapy, and 9 out of 15 patients had no detectable antibodies at any time. Transfusion reactions occurred in the presence of lymphocytotoxic antibodies not directed against donor cells.
D000293:Adolescent; D000328:Adult; D000380:Agranulocytosis / Q000628:therapy; D000961:Antilymphocyte Serum / Q000276:immunology*; D001803:Blood Transfusion; D002648:Child; D002675:Child, Preschool; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D006098:Granulocytes / Q000637:transplantation*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014181:Transplantation Immunology
D000961:Antilymphocyte Serum