title: [Action of actinomycin and alpha-amanitin on the RNA transcription of the influenza virus].
abstract: Complete (template RNA) and incomplete (messenger RNA) transcripts were separated by electrophoretic fractionation of RNA-hybrids containing unlabeled genome RNA of influenza virus and virus-specific antigenome 3H-RNAs obtained from infected cells. Incubation of the infected cells in the presence of actinomycin D or alpha-amanitine was shown to inhibit selectively viral mRNA synthesis. It is suggested that the synthesis of mRNA and template antigenome RNA of influenza virus is initiated by different mechanisms.
mesh_terms: D000546:Amanitins / Q000494:pharmacology*; D000818:Animals; D002642:Chick Embryo; D003609:Dactinomycin / Q000494:pharmacology*; D003864:Depression, Chemical; D009980:Influenza A virus / Q000187:drug effects* / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics*; D014158:Transcription, Genetic / Q000187:drug effects*
chemical_list: D000546:Amanitins; D012333:RNA, Messenger; D012367:RNA, Viral; D003609:Dactinomycin
vernacular_title: Deĭstvie aktinomitsina i al'fa-amanitina na transkriptsiiu RNK  virusa grippa.