[Role of mineralocorticoid regulation of vascular reactivity in the arterial pressure reaction to increased salt uptake in healthy persons].
The amplitude of vascular reactions to maximum doses of pressor agents was found to be higher in individuals with a high concentration of aldosterone in blood. From the results of salt load tests (400 mEq of sodium chloride daily) and the discovered positive correlation between the blood aldosterone concentration and the parameters of vascular reactivity, it is concluded that endogenous aldosterone contributes to the regulation of vascular reactivity. The authors believe that this regulatory mechanism is important in the reaction of arterial pressure to the intake of salt: in individuals with initially high blood aldosterone concentration, vascular reactivity and arterial pressure increase after the intake of salt, while in the other healthy individuals arterial pressure does not change.
D000328:Adult; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects*; D001808:Blood Vessels / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006262:Health; D006801:Humans; D006973:Hypertension / Q000209:etiology; D008875:Middle Aged; D008901:Mineralocorticoids / Q000502:physiology*; D009638:Norepinephrine / Q000008:administration & dosage; D012965:Sodium Chloride / Q000008:administration & dosage*
D008901:Mineralocorticoids; D000804:Angiotensin II; D012965:Sodium Chloride; D000450:Aldosterone; D009638:Norepinephrine
Rol' mineralokortikoidnoĭ reguliatsii sosudistoĭ reaktivnosti v reaktsii arterial'nogo davleniia na uvelichenie priema soli u zdorovykh liudeĭ.