Endometrial carcinoma after Hodgkin disease in childhood.
A 34-year-old patient developed metastic endometrial carcinoma after Hodgkin disease in childhood. She had ovarian failure after abdominal irradiation and chemotherapy for Hodgkin disease, and received exogenous estrogens, a treatment implicated in the development of endometrial cancer in menopausal women. Young women on replacement estrogens for ovarian failure after cancer therapy may also have increased risk of endometrial carcinoma and should be examined periodically.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000209:etiology*; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D045166:Estradiol Congeners / Q000009:adverse effects; D004967:Estrogens / Q000009:adverse effects; D005260:Female; D006689:Hodgkin Disease / Q000150:complications*; D006801:Humans; D009378:Neoplasms, Multiple Primary; D009381:Neoplasms, Radiation-Induced; D014594:Uterine Neoplasms / Q000139:chemically induced / Q000209:etiology*
D000970:Antineoplastic Agents; D045166:Estradiol Congeners; D004967:Estrogens