Electrophoretic analysis of specific proteins in the regenerating goldfish retinotectal pathway.
Proteins in the goldfish retinotectal pathway were analyzed by 2-D gel electrophoresis, under conditions of optic nerve crush or eye removal. A specific cluster of proteins was detected, consisting of 4 components, all of which are highly concentrated in the intact optic nerve. Two components were not detectable in non-visual areas of the goldfish brain. The total cluster was diminished by about 80% in the denervated optic tectum, and its level was restored during optic nerve regeneration. These data were interpreted as evidence for visual system-specific proteins in the goldfish retinotectal pathway.
D000818:Animals; D004292:Dominance, Cerebral / Q000502:physiology; D004586:Electrophoresis; D006054:Goldfish; D009416:Nerve Regeneration; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D012160:Retina / Q000378:metabolism*; D012683:Sensory Deprivation; D013477:Superior Colliculi / Q000378:metabolism*; D014795:Visual Pathways / Q000378:metabolism
D009419:Nerve Tissue Proteins