Role of intestinal metaplasia in the histogenesis of gastric carcinoma.
Recent evidence suggests that intestinal metaplasia (IM) cannot be regarded as a single entity. A simple classification of IM and its variants based on histological and mucin histochemical criteria was devised, and the incidence of IM subtypes in cancerous and benign gastrectomy specimens was recorded. A particular subtype was associated with 'intestinal' cancers but not with tumours considered to arise in normal gastric epithelium (P < 0.01) or with benign lesions (P < 0.01). This subtype appeared to lack absorptive cells at light microscopic level and secreted both neutral and acid mucins, including marked amounts of sulphomucin but no O-acetyl sialomucin.
D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007414:Intestinal Neoplasms / Q000145:classification / Q000473:pathology; D007422:Intestines / Q000473:pathology*; D008679:Metaplasia / Q000145:classification; D009077:Mucins / Q000378:metabolism; D013274:Stomach Neoplasms / Q000145:classification / Q000473:pathology*
D009077:Mucins