[Toxicity of burned skin high molecular weight protein according to the results of biological experiments in vivo and in vitro].
In vivo and in vitro experiments have demonstrated the toxic effect of high-molecular protein isolated from burnt skin extract (BSE) by immunosorption. The toxin preparations cause the death of mice with RES blockade and inhibit the leukocyte migration capacity in culture. It was shown in control experiments that BSE after passage through the immunosorbent fully loses its toxic properties because of toxin binding to insoluble-base-fixed antibodies.
D000818:Animals; D002056:Burns / Q000378:metabolism*; D002465:Cell Movement; D002478:Cells, Cultured; D007928:Lethal Dose 50; D007962:Leukocytes; D051379:Mice; D008970:Molecular Weight; D011506:Proteins / Q000633:toxicity*; D051381:Rats; D012867:Skin / Q000293:injuries*; D014118:Toxins, Biological / Q000302:isolation & purification*
D011506:Proteins; D014118:Toxins, Biological
Toksichnost' vysokomolekuliarnogo belka obozhzhennoĭ kozhi po rezul'tatam bioispytaniĭ in vivo i in vitro.