Fatty acids bound to serumalbumin decrease the half-life of thromboxane A2.
The half-life of thromboxane A2 is increased in plasma as well as in a buffer containing serumalbumin. Moreover, the half-life of thromboxane A2 depends on the amount of unesterified fatty acids bound to albumin. When more fatty acids are bound, the half-life is shortened. This shortening is accompanied by a decrease of the aggregating activity of thromboxane A2.
D055598:Chemical Phenomena; D002621:Chemistry; D005230:Fatty Acids, Nonesterified; D006207:Half-Life; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects; D011485:Protein Binding; D012709:Serum Albumin; D013928:Thromboxane A2 / Q000097:blood / Q000494:pharmacology; D013931:Thromboxanes / Q000097:blood
D005230:Fatty Acids, Nonesterified; D012709:Serum Albumin; D013931:Thromboxanes; D013928:Thromboxane A2