4-Aminopyridine blockade of neuronal depressant responses to adenosine triphosphate.
1 Adenosine, adenosine monophosphate and adenosine triphosphate (ATP) depressed the firing rate of neurones in the rat cerebral cortex when applied by microinontophoresis. 2 4-Aminopyridine, also applied iontophoretically blocked the depressant effects of the purines, without affecting responses to gamma-aminobutyric acid (GABA). This blockade was effected against purine depressions of both spontaneous and glutamate-evoked activity, suggesting that the interaction occurred postsynaptically.
D015761:4-Aminopyridine; D000241:Adenosine / Q000494:pharmacology; D000249:Adenosine Monophosphate / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000037:antagonists & inhibitors*; D000631:Aminopyridines / Q000494:pharmacology*; D000818:Animals; D005971:Glutamates / Q000494:pharmacology; D008297:Male; D009474:Neurons / Q000187:drug effects*; D051381:Rats; D013757:Tetraethylammonium Compounds / Q000494:pharmacology
D000631:Aminopyridines; D005971:Glutamates; D013757:Tetraethylammonium Compounds; D000249:Adenosine Monophosphate; D000255:Adenosine Triphosphate; D015761:4-Aminopyridine; D000241:Adenosine