[Therapeutic effect of calcium chloride in myocardial hypoxia caused by acute massive hemorrhage].
It was demonstrated in experiments on 119 adult dogs that acute massive blood loss leads to the development of hemorrhagic shock with marked signs of myocardial hypoxia, especially in the late period of the pathological process. These signs are not removed by various types of transfusion therapy and are among the causes of the animals' death. Intravenous infusion of 10% calcium chloride solution following transfusion therapy leads to marked diminution of tachycardia, restoration of sinus arrhythmia, decrease of general peripheral resistance, reduction of the capacity of the venous bed, acceleration of the blood flow rate, and normalization of the central mechanisms of cardiac activity regulation. The phenomena of myocardial hypoxia disappear as a result of which the development of irreparable changes is prevented and most of the animals survive.
D000208:Acute Disease; D000818:Animals; D001803:Blood Transfusion; D002122:Calcium Chloride / Q000627:therapeutic use*; D003327:Coronary Disease / Q000188:drug therapy*; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D005260:Female; D006439:Hemodynamics; D000860:Hypoxia / Q000188:drug therapy*; D008297:Male; D012771:Shock, Hemorrhagic / Q000188:drug therapy*
D002122:Calcium Chloride
Terapevticheskiĭ éffekt khloristogo ka'tsiia pri gipoksii miokarda, vyzvannoĭ ostroĭ massivnoĭ krovopotereĭ.