[Change in the properties of model membranes interacting with atherogenic and "antiatherogenic" classes of lipoproteins with varying physicochemical characteristics].
The work was undertaken for the purpose of studying the interaction of human blood plasma lipoproteins (LP) with bi-layer lipid membranes (BLM), which is regarded to be a model of nonreceptive interaction of LP with the cell membranes. The surface LP of very low density (LPVLD) layer is much "denser" in hyperalpha-lipoproteinemia than in hypoalpha-lipoproteinemia. It was found that atherogenic LP classes induce an increase in BLM conductivity in much lesser concentration than the subclasses of antiatherogenic LP of high density. LPVLD of individuals with their increased content in plasma increase the electrical capacity of BLM to a lesser extent than LPVLD of healthy individuals. In most experiments with LPVLD of individuals with their high level. BLM resilience diminished, whereas in experiments with LPVLD of persons with a normal LP spectrum, BLM resistance was found to be increased. It is thus shown that despite the absence of protein receptors in the BLM some of their physico-chemical characteristics change on interaction with blood plasma LP.
D000328:Adult; D001161:Arteriosclerosis / Q000097:blood / Q000209:etiology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004347:Drug Interactions; D006801:Humans; D008051:Lipid Bilayers / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D013113:Spin Labels
D008051:Lipid Bilayers; D008074:Lipoproteins; D013113:Spin Labels
Izmenenie svoĭstv model'nykh membran pri vzaimodeĭstvii s aterogennymi i "antiaterogennymi" klassami lipoproteidov s razlichnymi fiziko-khimicheskimi kharakteristikami.