Genetic polymorphism of human erythrocyte glyoxalase II.
A new method for the detection of glyoxalase II (hydroxyacylglutathione hydrolase) after starch gel electrophoresis is described. A survey of Asian-Pacific populations indicates that genetic polymorphism of glyoxalase II is extremely rare. Polymorphism was observed only in a Micronesian population from the island of Nauru, in which the frequency of the new variant allele HAGH2 was found to be .016. The electrophoretic pattern in heterozygotes was a double band, suggesting that the structure of glyoxalase II is monomeric.
D000483:Alleles; D044466:Asian People; D044383:Black People; D004592:Electrophoresis, Starch Gel; D004912:Erythrocytes / Q000201:enzymology; D006801:Humans; D008849:Micronesia; D010375:Pedigree; D010641:Phenotype; D011110:Polymorphism, Genetic; D013869:Thiolester Hydrolases / Q000235:genetics*; D000099301:Hydroxyacylglutathione Hydrolase
D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase