Faecal bile acid excretion in diverticular disease.
Faecal bile acid excretion and sigmoid myoelectrical activity were measured on three separate occasions over a 12-month period in 21 patients with diverticular disease and the result were compared with those of 17 age-matched normal subjects. Statistically significantly lower faecal concentrations of both deoxycholic and lithocholic acid were found in patients with diverticular disease (96.7 +/- 11.3 mg/100 g, 59.6 +/- 6.0 mg/100 g respectively) when compared with normal subjects (219 +/- 32.0 mg/100 g and 117.6 +/- 14.6 mg/100 g respectively, P < 0.001). These values persisted throughout the period of study. Patients with diverticular disease were found to have an abnormally rapid myoelectrical rhythm (frequency 0.2-0.3 Hz [12-18 c/min] which returned towards normal after 1 year's bran treatment. Significant correlations were found between lithocholic acid concentrations and activity of 0.2-0.3 Hz (r = 0.67) and deoxycholic acid concentrations and activity of 0.1-015 Hz (6-9 c/min) (r = 0.62). It is suggested that increased colonic absorption of bile acids may occur in diverticular disease which may influence the myoelectrical activity.
D001647:Bile Acids and Salts / Q000378:metabolism*; D012809:Colon, Sigmoid / Q000503:physiopathology; D003840:Deoxycholic Acid / Q000378:metabolism; D004241:Diverticulum, Colon / Q000378:metabolism* / Q000503:physiopathology; D004576:Electromyography; D005243:Feces / Q000032:analysis*; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D008095:Lithocholic Acid / Q000378:metabolism; D008297:Male
D001647:Bile Acids and Salts; D003840:Deoxycholic Acid; D008095:Lithocholic Acid