Linkage studies on glyoxalase I (GLO), pepsinogen (PG), spinocerebellar ataxia (SCA1), and HLA.
Pedigree analyses of five families in which a form of spinocerebellar ataxia (SCA1) is present have been used to obtain additional information on the location of SCA1 on chromosome 6. Recombination rates with HLA and glyoxalase I (GLO) suggest that the order is HLA-GLO-SCA1. There was no evidence for linkage of pepsinogen isozyme-5 (PG) either to HLA or GLO.
D002524:Cerebellar Ataxia / Q000235:genetics*; D002874:Chromosome Mapping; D002906:Chromosomes, Human, 6-12 and X / Q000648:ultrastructure; D005260:Female; D005796:Genes; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000235:genetics*; D008190:Lyases / Q000235:genetics*; D008297:Male; D010435:Pepsinogens / Q000235:genetics*; D011995:Recombination, Genetic
D006680:HLA Antigens; D010435:Pepsinogens; D008190:Lyases; D007791:Lactoylglutathione Lyase