The effects of vincristine on platelet aggregation studied by a filter loop technique in the rat.
1 A method for measuring aggregation of platelets of adenosine diphosphate (ADP) is described using a filter inserted into the flowing aortic blood in the rat. 2 Repeated infusions of ADP resulted in a fall in the calculated aggregation index without significant changes in the platelet count. 3 Vincristine (0.05 mg/kg) intravenously caused significant inhibition of ADP-induced platelet aggregation. 4 Infusion of ADP caused some peripheral vasodilatation though it is unlikely that this contributed to the effects seen to any great extent.
D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005374:Filtration; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D014665:Vasodilator Agents / Q000494:pharmacology; D014750:Vincristine / Q000494:pharmacology*
D014665:Vasodilator Agents; D014750:Vincristine; D000244:Adenosine Diphosphate