[Pathogenesis of skeletal radiation injuries to the proximal portion of the pelvic extremity in white rat embryos].
The mechanisms forming certain anomalies in the pelvic proximal part in the offspring of white rats subjected to x-ray radiation on the 12th and 13th days of gestation have been analysed. Serial sections of the embryos performed at various time after radiation and electron microscopic investigations have demonstrated that radiation lesions in the locomotor apparatus are of different pathogenesis. Defects in the femoral and pelvic bones, their fusion in the coxofemoral joint are anomalies resulted from destruction of some mesenchymal cells in the proximal part of the pelvic bud. Femoral dislocation, formed during gestation, is a result of disorders in coordinative muscle development, surrounding the joint and that of hypoplasia in the bursae-ligamentous apparatus (lack of head ligament, hypoplasia of the acetabular lip). Power disbalance in the muscles surrounding the joint is the main course resulting in dislocation of the femoral head.
D000818:Animals; D001848:Bone Diseases, Developmental / Q000196:embryology / Q000209:etiology*; D004622:Embryo, Mammalian / Q000528:radiation effects*; D005260:Female; D008159:Lumbar Vertebrae / Q000196:embryology / Q000528:radiation effects; D008854:Microscopy, Electron; D010384:Pelvic Bones / Q000196:embryology / Q000528:radiation effects*; D011247:Pregnancy; D011833:Radiation Injuries, Experimental / Q000196:embryology / Q000209:etiology*; D051381:Rats; D014965:X-Rays
Patogenez luchevykh povrezhdeniĭ skeleta proksimal'nogo otdela tazovoĭ konechnosti u émbrionov beloĭ krysy.