Human fetal growth retardation. Metabolic response of leukocytes to phagocytosis.
The basal and stimulated metabolism of leukocytes obtained from fetally malnourished and normal children was comparatively studied. All basal activities of the leukocytes from malnourished children were significantly lower than those observed in normal children: Glucose-6-P-deydrogenase activity was 1.04 +/- 0.12 against 1.27 +/- 0.22 mumoles/min/10(8) cells; leukocyte-oxidase activity was 0.19 +/- 0.03 against 0.31 +/- 0.05 OD units/15 min/2.5 x 10(6) cells, oxygen uptake was 384 +/- 48 against 728 +/- 103 nmoles 0(2)/hr/10(8) cells. The conversion of glucose -1(14)C to 14CO2 was 83 +/- 10 nmoles/10(8) cells in malnourished children and 134 +/- 22 in controls. The response of all the parameters studied to the stimulation of phagocytosis was also significantly lower in fetally malnourished than in control babies.
D005260:Female; D005317:Fetal Growth Retardation / Q000201:enzymology / Q000276:immunology*; D005954:Glucosephosphate Dehydrogenase / Q000378:metabolism; D006801:Humans; D007962:Leukocytes / Q000201:enzymology / Q000276:immunology / Q000378:metabolism*; D010101:Oxygen Consumption; D010587:Phagocytosis; D011247:Pregnancy
D005954:Glucosephosphate Dehydrogenase