Liver damage in rats during acute carbon monoxide poisoning.
Plasma leucine aminopeptidase (LAP) levels and respiration rates of isolated liver mitochondria were studied in carbon monoxide (CO)-poisoned rats sampled at respiratory arrest. An increase in LAP levels paralleled a decrease in the respiratory control ratio and the ADP/O ratio. The results suggest that the damage to mitochondria closely correlates with the liver damage in rats during acute CO poisoning.
D000818:Animals; D002248:Carbon Monoxide / Q000009:adverse effects*; D002249:Carbon Monoxide Poisoning / Q000473:pathology*; D002263:Carboxyhemoglobin / Q000032:analysis; D007931:Leucyl Aminopeptidase / Q000097:blood; D008099:Liver / Q000187:drug effects / Q000648:ultrastructure*; D008297:Male; D008930:Mitochondria, Liver / Q000187:drug effects* / Q000648:ultrastructure; D051381:Rats
D002248:Carbon Monoxide; D002263:Carboxyhemoglobin; D007931:Leucyl Aminopeptidase