Subcutaneous infection with phialophora richardsiae and its susceptibility to 5-fluorocytosine, amphotericin B and miconazole.
Two patients are described with subcutaneous infections due to Phialophora richardsiae. Both were diabetics and originally came from subtropical areas. One of the patients had a cystic lesion which was well encapsulated while the other had a large ulcerating lesion with draining sinus tracts. The organisms were found to be susceptible to cycloheximide but resistant to 5-fluorocytosine, miconazole and amphotericin B. There was some variability in the degree of resistance depending upon whether the primary or secondary phialoconidia were tested. While simple excision appears curative for the solitary cystic type of lesion, therapy of the ulcerating form of the disease remains problematic.
D000328:Adult; D000368:Aged; D000666:Amphotericin B / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology; D003596:Cytosine / Q000031:analogs & derivatives*; D004352:Drug Resistance, Microbial; D005437:Flucytosine / Q000494:pharmacology*; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology*; D008297:Male; D008825:Miconazole / Q000494:pharmacology*; D009181:Mycoses / Q000382:microbiology* / Q000473:pathology; D010676:Phialophora / Q000166:cytology / Q000187:drug effects*
D007093:Imidazoles; D008825:Miconazole; D000666:Amphotericin B; D003596:Cytosine; D003513:Cycloheximide; D005437:Flucytosine