Effect of model traumatic injury on hepatic drug-metabolizing enzymes.
Abdominal aorta ligation in rats was found to be a suitable model traumatic injury for the study of the effect of trauma on drug-metabolizing enzymes. This procedure was found to result in a rapid decrease in both cytochrome P-450 and mixed function amine oxidase activities. Recovery of mixed function amine oxidase activity was slower than recovery of cytochrome P-450 activity.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000032:analysis; D004195:Disease Models, Animal; D008099:Liver / Q000201:enzymology*; D008297:Male; D006899:Mixed Function Oxygenases / Q000032:analysis; D000587:Oxidoreductases Acting on CH-NH Group Donors / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D014947:Wounds and Injuries / Q000201:enzymology*
D004364:Pharmaceutical Preparations; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; D000587:Oxidoreductases Acting on CH-NH Group Donors