Treatment of alcoholic cirrhosis with enzyme inducers.
The efficacy of hepatic enzyme-inducing drugs in improving liver function and drug metabolism was investigated in 18 chronic alcoholics with cirrhosis. Five subjects treated continuously with the inducing drugs, phenytoin or prednisolone, for concomitant diseases showed more rapid metabolism than the other patients. Phenobarbital (PB) and medroxyprogesterone acetate (MPA), both known inducers, improved drug metabolism in patients with normal or decreased serum albumin. Serum albumin levels rose in alcoholics with low pretherapy levels, whereas serum albumin in subjects with normal pretherapy levels did not change. Serum thrombotest levels rose in six of seven subjects with low pretreatment values. There was a trend toward normal conventional liver tests during the experiment. There was a relationship between in vivo and in vitro drug metabolism in the alcoholics with cirrhosis. Our results demonstrate that by activating liver function, enzyme-inducing drugs may be of therapeutic value in alcoholics with liver cirrhosis and hepatic failure.
D000328:Adult; D000368:Aged; D004790:Enzyme Induction; D005260:Female; D006801:Humans; D008099:Liver / Q000378:metabolism; D008104:Liver Cirrhosis, Alcoholic / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D008525:Medroxyprogesterone / Q000627:therapeutic use*; D008875:Middle Aged; D004364:Pharmaceutical Preparations / Q000378:metabolism; D010634:Phenobarbital / Q000627:therapeutic use*; D012709:Serum Albumin / Q000032:analysis
D004364:Pharmaceutical Preparations; D012709:Serum Albumin; D008525:Medroxyprogesterone; D010634:Phenobarbital