Treatment of bovine and equine ocular squamous cell carcinoma by radiofrequency hyperthermia.
Forty-five ocular squamous cell carcinomas (SCC) in 17 cattle and 8 horses were treated by radiofrequency hyperthermia, resulting in 80% complete regression and 16% partial regression. Tumors were histologically diagnosed as SCC; 50% of the tumors were recurrent, having been treated previously by surgery, cryosurgery, radiation, or immunotherapy. After hyperthermic treatment, most animals were available for tumor measurement at 4 to 6 weeks and at 8 to 16 weeks, with a final observation period of 2 to 10 months for all. Complete regression occurred in 8 of 12 tumors given a second hyperthermic treatment. It was concluded that hyperthermia is an effective and easily applied treatment modality for ocular SCC in cattle and horses; however, it cannot be recommended for large tumors (larger than equal to 5 cm diameter) that have deep eyelid or conjunctival penetration.
D000818:Animals; D002294:Carcinoma, Squamous Cell / Q000628:therapy / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000628:therapy*; D003316:Corneal Diseases / Q000628:therapy / Q000662:veterinary; D005134:Eye Neoplasms / Q000628:therapy / Q000662:veterinary*; D006734:Horse Diseases / Q000628:therapy*; D006736:Horses; D006358:Hot Temperature / Q000627:therapeutic use*; D011846:Radio Waves