title: Treatment of moderate to severe gastro-oesophageal reflux with an alginate/antacid combination.
abstract: An open study was carried out in 37 patients, with chronic, moderate to severe gastric or bilious reflux associated with hiatus hernia or subsequent to gastro-oesophageal surgery, to assess the effectiveness of an alginate/antacid combination product ('Gastrocote'). The overall success rate of treatment was 81% after 6 months, 23 (62.2%) having complete relief of symptoms and 7 (18.9%) experiencing only occasional symptoms. The 7 patients who failed to respond required surgical repair of their hiatus hernia. No adverse effects of treatment were reported.
mesh_terms: D000328:Adult; D000368:Aged; D000464:Alginates / Q000009:adverse effects / Q000627:therapeutic use*; D000863:Antacids / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005764:Gastroesophageal Reflux / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged
chemical_list: D000464:Alginates; D000863:Antacids; D004338:Drug Combinations