The bronchodilator activity of 20-isopropylidene prostaglandin E2 (CS-412).
The bronchodilator activity of 20-isopropylidene prostaglandin E2 (CS-412) was studied in vivo. In the conscious guinea pig, aerosols of CS-412, prostaglandin E2 (PGE2), or salbutamol afforded similar protection against histamine-induced convulsions. In the anesthetized guinea pig, where increase in intratracheal pressure was taken as an index of bronchoconstriction, CS-412, PGE2, and salbutamol were equipotent in inhibiting the broncho-constriction induced by histamine. CS-412, PGE2 and salbutamol were equally effective in reducing the serotonin-induced increase in pulmonary resistance in the anesthetized cat. CS-412 was different from PGE2 in bronchoconstrictor activity in anesthetized cats with normal bronchotonus. PGE2 caused bronchoconstriction in the cats. CS-412 showed 30 times less constrictor activity than PGE2. It was concluded that CS-412 is an effective bronchodilator without unfavorable side effects.
D000420:Albuterol / Q000494:pharmacology*; D000758:Anesthesia; D000818:Animals; D001980:Bronchi / Q000187:drug effects; D001986:Bronchial Spasm / Q000188:drug therapy*; D001993:Bronchodilator Agents / Q000494:pharmacology*; D002415:Cats; D015232:Dinoprostone / Q000031:analogs & derivatives*; D004305:Dose-Response Relationship, Drug; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000494:pharmacology; D008297:Male; D011458:Prostaglandins E / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*; D012702:Serotonin Antagonists / Q000494:pharmacology
D001993:Bronchodilator Agents; D006633:Histamine Antagonists; D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D012702:Serotonin Antagonists; C024305:20-isopropylidene prostaglandin E2; D015232:Dinoprostone; D000420:Albuterol