Antigenic high molecular weight material in penicillin preparations.
Using a radioimmunoassay, RIA, small amounts of high molecular weight antigens have been reproducibly identified in both biosynthetic and semisynthetic brands of penicillin. These impurities were found to be eliminated by simple chemical means. Measures to avoid this type of contaminants in penicillin preparations should be undertaken because of the immunogenic nature of the contaminants resulting in increased risk of sensitization of patients to penicillin.
D000941:Antigens / Q000032:analysis*; D008970:Molecular Weight; D010406:Penicillins / Q000032:analysis* / Q000276:immunology / Q000592:standards; D011863:Radioimmunoassay
D000941:Antigens; D010406:Penicillins