Treatment of mesangiocapillary glomerulonephritis in children with combined immunosuppression and anticoagulation.
10 children with mesangiocapillary (membranoproliferative) glomerulonephritis with features associated with a poor prognosis (either crescentic nephritis or a decline in renal function occurring after the initial presentation) were treated with a combination of immunosuppression and anticoagulation using corticosteroids, azathioprine, and heparin followed by warfarin and dipyridamole. Children were followed up for between 2 and 5 years, and at the end of this period 2 had died and 2 had entered the dialysis/transplant programme, but 6 were well (5 with glomerular filtration rates greater than 65 ml/min per 1 x 73 m2). We suggest that these results are sufficiently promising to encourage further trials of this form of treatment.
D000293:Adolescent; D001379:Azathioprine / Q000627:therapeutic use*; D002648:Child; D004176:Dipyridamole / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D005921:Glomerulonephritis / Q000188:drug therapy* / Q000503:physiopathology; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D007668:Kidney / Q000503:physiopathology; D008297:Male; D011241:Prednisone / Q000627:therapeutic use*; D014859:Warfarin / Q000627:therapeutic use*
D014859:Warfarin; D004176:Dipyridamole; D006493:Heparin; D001379:Azathioprine; D011241:Prednisone