Audiotoxicosis in newborn guinea pigs from pregnant ones given sisomicin.
The audiotoxic effect of sisomicin was investigated in guinea pig injected intramuscularly with 6.25, 12.5, 25 and 50 mg/kg of sisomicin sulfate (potential) during weeks 1--5 or 5--9 of pregnancy, and the transplacental effect on their offspring was studied. While, in some dams the higher doses of sisomicin produced a limited effect on the pinna reflex and the outer hair cells of the organ of Corti, no such effects were noted in any of the offspring during the 3-week postnatal observation period.
D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005839:Gentamicins / Q000633:toxicity*; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects; D006309:Hearing / Q000187:drug effects*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D012853:Sisomicin / Q000633:toxicity*
D005839:Gentamicins; D012853:Sisomicin