title: Activation of complement by Naegleria.
abstract: Neither Naegleria nor its culture supernatant was found to be directly chemotactic for human neutrophils. Interaction of Naegleria with human serum, however, resulted in the generation of a strong chemotactic stimulus. The reduction of serum activity by heat-inactivation indicated a dependence on serum complement for the interaction. The ability of Naegleria to activate the alternative complement pathway was demonstrated with the use of C2-deficient serum.
mesh_terms: D000656:Amoeba / Q000276:immunology*; D002634:Chemotaxis, Leukocyte; D003167:Complement Activation; D003175:Complement C2 / Q000032:analysis; D003170:Complement Pathway, Alternative; D006801:Humans; D066298:In Vitro Techniques; D009504:Neutrophils / Q000502:physiology
chemical_list: D003175:Complement C2