Synthesis of DNA in oestrogen-induced pituitary tumurs in rats: effect of bromocriptine.
Bromocriptine increased the concentration of prolactin in oestrogen-induced tumours of the rat pituitary gland. Prolactinaemia was significantly reduced and at the same time there was a considerable decrease in the weight of the tumour, in the incorporation of tritiated thymidine into DNA and in the activity of DNA polymerase alpha. The results suggested that the intracellular content of prolactin controls cell proliferation in this experimental tumour. A hypothalamic disorder is proposed as the primary cause of these tumours.
D000236:Adenoma / Q000139:chemically induced / Q000378:metabolism*; D000818:Animals; D001971:Bromocriptine / Q000494:pharmacology*; D004256:DNA Polymerase I / Q000378:metabolism; D004273:DNA, Neoplasm / Q000096:biosynthesis*; D004054:Diethylstilbestrol; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000187:drug effects; D010911:Pituitary Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D011388:Prolactin / Q000378:metabolism; D051381:Rats; D011916:Rats, Inbred F344
D004273:DNA, Neoplasm; D001971:Bromocriptine; D004054:Diethylstilbestrol; D011388:Prolactin; D004256:DNA Polymerase I