Genetic polymorphism of human plasminogen.
Using isoelectric focusing (IEF) in polyacrylamide gel of neuraminidase-treated serum or plasma samples and immunofixation or caseinolytic overlay after urokinase activation of gels, a common genetic polymorphism in human plasminogen has been delineated. Two alleles PLGN*A and PLGN*B, were observed with gene frequencies in whites of .69 and .30; in Orientals of .96 and .03; and in blacks of .80 and .18. Several rare alleles were also found. The distribution of phenotypes fits the Hardy-Weinberg equilibrium. Inheritance is autosomal codominant and fits the expectations of Mendelian inheritance. There is fetal synthesis, but no transplacental passage of plasminogen in either direction.
D000328:Adult; D000483:Alleles; D044466:Asian People; D044383:Black People; D005260:Female; D005787:Gene Frequency; D005799:Genes, Dominant; D014644:Genetic Variation; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007122:Immunoelectrophoresis; D007231:Infant, Newborn; D007525:Isoelectric Focusing; D008297:Male; D008431:Maternal-Fetal Exchange; D010958:Plasminogen / Q000235:genetics* / Q000276:immunology; D011110:Polymorphism, Genetic; D011247:Pregnancy; D044465:White People
D010958:Plasminogen