Damage by dichlorvos of human lymphocyte DNA.
The action of dichlorvos (2,2-dichlorovinyldimethyl phosphate) was studied with a short-term in vitro system which utilizes lymphocytes. The parameters studied were the action exerted by the pesticide on scheduled (semiconservative) and unscheduled (reparative) DNA synthesis measured as tritiated thymidine uptake. The results obtained show that dischlovos affects semiconservative DNA synthesis, damages human lymphocyte DNA inducing low reparative synthesis, and interferes with DNA repair processes after damage exerted by ultraviolet rays.
D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D004260:DNA Repair / Q000187:drug effects*; D004006:Dichlorvos / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects; D014466:Ultraviolet Rays
D004006:Dichlorvos; D004247:DNA