Evidence for an involvement of acetylcholine in self-stimulation of the prefrontal cortex in the rat.
The effects of injections of antagonists of muscarinic and nicotinic receptors on self-stimulation of the prefrontal cortex in the rat were studied. The results of this investigation suggest that acetylcholine is involved in self-stimulation of the prefrontal cortex through activation of muscarinic receptors, and also suggest a possible interaction between acetylcholine and dopamine in mediating self-stimulation of this area of the brain.
D000109:Acetylcholine / Q000502:physiology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D003909:Dexetimide / Q000494:pharmacology*; D004327:Drinking Behavior / Q000187:drug effects; D004558:Electric Stimulation; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D011976:Receptors, Muscarinic / Q000187:drug effects; D011978:Receptors, Nicotinic / Q000187:drug effects; D012601:Scopolamine / Q000494:pharmacology*; D012653:Self Stimulation / Q000187:drug effects*
D010880:Piperidines; D011976:Receptors, Muscarinic; D011978:Receptors, Nicotinic; D003909:Dexetimide; D012601:Scopolamine; D000109:Acetylcholine