[Comparative study of the effectiveness of the interferon inducers, poly(I) : poly(C) and GSS (gossypol-beta-aminoethylsodium sulfate), in combination with a specific vaccine in experimental infection with the human acute encephalomyelitis virus].
Using the model of human acute encephalomyelitis virus (HAEM) infection it was found that inoculation of mice with interferon inducers poly(I): poly(C) or GSS at the site of virus inoculation prevented the lethal outcome of the infection. The effectiveness of the inducers increased markedly when used in combination with the specific vaccine against HAEM virus. Both with inducers alone and in combination with the vaccine, the level of mouse protection in experiments with poly(I): poly(C) was higher than in those using GSS. The higher level of protection achieved by the administration of the inducers and the vaccine was shown to be due both to interferon production and activation of cellular immunity mechanisms.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D004353:Drug Evaluation, Preclinical; D004668:Encephalitis Viruses / Q000276:immunology*; D004679:Encephalomyelitis / Q000517:prevention & control*; D006072:Gossypol / Q000031:analogs & derivatives* / Q000627:therapeutic use; D007111:Immunity, Cellular / Q000187:drug effects; D007136:Immunoglobulins / Q000032:analysis; D007369:Interferon Inducers; D051379:Mice; D011070:Poly I-C / Q000627:therapeutic use*; D014765:Viral Vaccines / Q000008:administration & dosage*
D007136:Immunoglobulins; D007369:Interferon Inducers; D014765:Viral Vaccines; C026676:gossypol beta-aminoethyl sodium sulfate; D006072:Gossypol; D011070:Poly I-C
Sravnitel'noe izuchenie éffektivnosti induktorov interferona poli(IO-poli(Ts) i GSN (gossipol-beta-aminoétilsernokislyi natrii) pri ikh sochetannom primenenii so spetsificheskoĭ vaktsinoĭ pri éksperimental'noĭ infektsii virusom ostrogo éntsefalomielita cheloveka.