title: Antiandrogenic effect of cimetidine in mice.
abstract: Cimetidine (Tagamet) in the relatively high doses employed produced significant changes in seminal vesicles and kidney in mice. Cimetidine blocked the effect both of endogenous and of exogenous testosterone.
mesh_terms: D000311:Adrenal Glands / Q000033:anatomy & histology / Q000187:drug effects; D000726:Androgen Antagonists; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002927:Cimetidine / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D007668:Kidney / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012669:Seminal Vesicles / Q000033:anatomy & histology* / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology
chemical_list: D000726:Androgen Antagonists; D006146:Guanidines; D013739:Testosterone; D002927:Cimetidine