Serum CPK enzymes in myocardial ischemia followed by reperfusion.
Results from 30 experiments designed to correlate changes in serum creatine phosphokinase (CPK) enzyme concentration, myocardial tissue CPK enzyme content, and myocardial ultrastructure following myocardial ischemia and subsequent reperfusion are presented. The highest and most remarkable change is seen in 1 hr of ischemia followed by 24 hr of reperfusion. In this group, myocardial tissue CPK content is maintained during ischemia as well as reperfusion, indicating adequate enzyme synthesis to offset the enzyme leaking into blood serum simultaneously. The myocardial cells also show recovery in ultrastructure after reperfusion. The finding indicates that short periods of myocardial ischemia, such as this, are compatible with cell survival if adequate perfusion is restored early. Change in serum CPK enzymes, in this case, may indicate successful revascularization rather than development of an infarct.
D000818:Animals; D002470:Cell Survival; D003327:Coronary Disease / Q000201:enzymology* / Q000473:pathology; D003402:Creatine Kinase / Q000032:analysis* / Q000097:blood; D004285:Dogs; D005260:Female; D008297:Male; D008854:Microscopy, Electron; D009206:Myocardium / Q000201:enzymology* / Q000648:ultrastructure; D010477:Perfusion
D003402:Creatine Kinase