Prostaglandin E release by rat medial basal hypothalamus in vitro. Inhibition by melatonin at submicromolar concentrations.
Melatonin depressed PGE release by rat medial basal hypothalamus (MBH) in vitro at concentrations 10(-8) M or greater. The two-fold increase in PGE release induced by adding 10(-4) M norepinephrine to MBH explants was also impaired by melatonin at micromolar or greater concentrations. These data support the view that melatonin is a physiological inhibitor of PG synthesis in MBH.
D000818:Animals; D007031:Hypothalamus / Q000187:drug effects*; D007033:Hypothalamus, Middle / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D008297:Male; D008550:Melatonin / Q000494:pharmacology*; D011458:Prostaglandins E / Q000378:metabolism*; D051381:Rats
D011458:Prostaglandins E; D008550:Melatonin