Proteinuria following nephroangiography. V. Influence of calcium and magnesium ions in non-ionic contrast media.
The influence on albuminuria following nephroangiography was investigated after addition of Ca2+ to the non-ionic contrast medium metrizamide (Amipaque) in the rat and after addition of Ca2+ or Ca2+ and Mg2+ to the experimental non-ionic contrast medium C 29 in the dog. When Ca2+ or CA2+ and Mg2+ were added to metrizamide or C29 in concentrations two to three times th plasma level no influence occurred. Higher concentrations of Ca2+ (10-25 mmol/l) in the metrizamide or C29 solutions resulted in increased albuminuria.
D000419:Albuminuria / Q000139:chemically induced*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D002118:Calcium / Q000008:administration & dosage / Q000494:pharmacology*; D003287:Contrast Media / Q000009:adverse effects*; D004285:Dogs; D007479:Iopamidol / Q000031:analogs & derivatives*; D007483:Iothalamic Acid / Q000009:adverse effects / Q000031:analogs & derivatives; D008274:Magnesium / Q000008:administration & dosage / Q000494:pharmacology*; D008793:Metrizamide / Q000009:adverse effects; D011859:Radiography; D051381:Rats; D012077:Renal Artery / Q000000981:diagnostic imaging*
D003287:Contrast Media; D007483:Iothalamic Acid; C020687:C 29 (contrast media); D008274:Magnesium; D007479:Iopamidol; D008793:Metrizamide; D002118:Calcium