title: [Epimestrol in the treatment of normoprolactinemic corpus-lutem deficiency (author's transl)].
abstract: The treatment of normoprolactinemic corpus-luteum deficiency with epimestrol is reported. This is a frequent cause of infertility. The clinical and hormonal parameters for the diagnosis and follow-up evaluation of the treatment are described. In the present series 10 of 17 patients with primary infertility and normoprolactinemic corpus-luteum deficiency showed a normalization of the luteal phase. Two pregnancies occured following one cycle of treatment with epimestrol at 5 mg. daily from day 3 to day 12 of the cycle. Epimestrol shows no anti-estrogenic properties in contra-distinction to other ovulation stimulating drugs. The quality of the cervical secretion is therefore not impaired by epimestrol. Side effects or ovarian cysts were not observed.
mesh_terms: D000328:Adult; D002582:Cervix Mucus / Q000187:drug effects; D003338:Corpus Luteum; D004836:Epimestrol / Q000494:pharmacology / Q000627:therapeutic use*; D004963:Estrenes / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000209:etiology; D010049:Ovarian Diseases / Q000150:complications / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood*
chemical_list: D004963:Estrenes; D004836:Epimestrol; D011388:Prolactin
vernacular_title: Epimestrol in der Behandlung der normoprolaktinämischen Corpus-luteum-Insuffizienz.