The biological activity of 5,6-epoxyretinoic acid.
The potential of all-trans-5,6-epoxyretinoic acid to promote growth in vitamin A-deficient rats was evaluated over a 25-fold dose range using single daily intraperitoneal injections. 5,6-Epoxyretinoic acid was found to be 0.5% as active as all-trans-retinoic acid. The discrepancies between the present results and those obtained previously by other workers are discussed.
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004852:Epoxy Compounds / Q000008:administration & dosage / Q000494:pharmacology; D006128:Growth / Q000187:drug effects; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D014212:Tretinoin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D014802:Vitamin A Deficiency / Q000188:drug therapy
D004852:Epoxy Compounds; C018058:5,6-epoxyretinoic acid; D014212:Tretinoin