Pituitary cretinism in two sisters.
Two sisters with cretinism are reported. Each showed low levels of serum triiodothyronine, thyroxine, and thyroid-stimulating hormone (TSH). In the elder sister, serum TSH did not increase after administration of thyrotropin-releasing hormone. We conclude that cretinism in these 2 sisters was due to TSH deficiency. This is the second report of 'familial' pituitary cretinism (TSH-deficient congenital hypothyroidism).
D003409:Congenital Hypothyroidism / Q000235:genetics*; D005260:Female; D006801:Humans; D007223:Infant; D010375:Pedigree; D013972:Thyrotropin / Q000172:deficiency*
D013972:Thyrotropin