Effect of halothane and enflurane anaesthesia on the level of reduced glutathione in human red blood cells.
No significant changes were found in packed cell volume, haemoglobin concentration and red cell glutathione levels in patients before and after anaesthesia with halothane or enflurane. These results, though unable to explain the mechanism, support the earlier suggestion that glutathione plays little, if any, role in protecting liver against toxic effects of these anaesthetic agents or their metabolites.
D000328:Adult; D004737:Enflurane / Q000494:pharmacology*; D004912:Erythrocytes / Q000032:analysis / Q000187:drug effects*; D005978:Glutathione / Q000097:blood*; D006221:Halothane / Q000494:pharmacology*; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008099:Liver / Q000187:drug effects
D006454:Hemoglobins; D004737:Enflurane; D005978:Glutathione; D006221:Halothane