Physiologic changes in awake goats after experimentally induced pericardial effusion.
Awake, unmedicated goats were used to study the physiologic effects of experimentally induced acute pericardial effusion. With an increase in pericardial volumes, there was a significant (P < 0.01) linear decrease in the cardiac index. This decrease was apparently due to the decrease in stroke index (P < 0.01) rather than to a decrease in heart rate. Peripheral vascular resistance in both the systemic and pulmonary arteries increased. The aortic pressure initially fell, but later rose with an increase in pericardial volumes. Pulmonary arterial pressures decreased with an increase in pericardial volumes. Pressure in the right atrium were significantly elevated (P < 0.01) with an increase in pericardial volumes.
D000818:Animals; D001794:Blood Pressure; D002302:Cardiac Output; D006041:Goats / Q000502:physiology*; D010490:Pericardial Effusion / Q000502:physiology*; D011651:Pulmonary Artery / Q000502:physiology; D014655:Vascular Resistance; D014851:Wakefulness