title: Effect of picrotoxin and nipecotic acid on inhibitory response of dopaminergic neurons in the ventral tegmental area to stimulation of the nucleus accumbens.
abstract: Electrical stimulation of nucleus accumbens inhibited the activity of neurons in the ventral tegmental area (VTA). Inhibition was potentiated by nipecotic acid, a GABA uptake inhibitor, and was attenuated by picrotoxin, a GABA antagonist. Four units inhibited by nucleus accumbens stimulation were also antidromically activated. These observations suggest that neurons in the VTA, including specifically those projecting to the nucleus accumbens, receive a descending GABAergic input from that area.
mesh_terms: D000818:Animals; D004298:Dopamine / Q000502:physiology*; D004553:Electric Conductivity; D004558:Electric Stimulation; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009557:Nipecotic Acids / Q000494:pharmacology*; D009714:Nucleus Accumbens / Q000502:physiology*; D010852:Picrotoxin / Q000494:pharmacology*; D051381:Rats; D012686:Septal Nuclei / Q000502:physiology*; D013681:Tegmentum Mesencephali / Q000187:drug effects / Q000502:physiology*
chemical_list: D004298:Dopamine; D009557:Nipecotic Acids; D010852:Picrotoxin