[Topical indomethacin before cataract surgery without implantation - Ineffectiveness of a single dose administration (author's transl)].
This is a double blind study on the eventual effect a single dose administration of an indomethacin collyrium given prior to surgery of cataract without implantation. The goal is to decrease post-operative reactions. Twenty patients were treated with indomethacin and then operated. Twenty witnesses were operated without prior administration of the collyrium. The control parameters were the following: the cell tyndall of the anterior chamber, the protein tyndall of the anterior chamber and the intra-ocular pressure. The parameters were studied from the first to the fifth post-operative day and on the fourteenth day. In some cases, structures of the anterior segment were explored by means of prolonged fluoroangiography. The goal was to study the permeability of the blood aqueous barrier. No significant difference was found between the two groups for any of the studied parameters. The result shows the ineffectiveness of a single dose administration of indomethacin in reducing postoperative reactions that result from lens extraction.
D000368:Aged; D000867:Anterior Chamber / Q000166:cytology / Q000187:drug effects; D002387:Cataract Extraction; D004311:Double-Blind Method; D005136:Eye Proteins / Q000032:analysis; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage* / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011292:Premedication
D005136:Eye Proteins; D009883:Ophthalmic Solutions; D007213:Indomethacin
Indométacine locale et chirurgie de la cataracte sans implantation, inefficacité d'une dose unique préalable.