Synaptic development in brains of rats exposed perinatally to ethanol.
Development of brain synaptosomal uptakes of 3H-norepinephrine and 3H-dopamine in pups whose mothers received ethanol were nearly normal. However, development of synaptosomal uptake of 3H-serotonin was significantly lower than in controls, while uptake of 3H-norepinephrine into synaptic storage vesicles was increased.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D005260:Female; D005333:Fetus / Q000187:drug effects*; D066298:In Vitro Techniques; D009638:Norepinephrine / Q000378:metabolism; D011247:Pregnancy; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism*
D012701:Serotonin; D000431:Ethanol; D004298:Dopamine; D009638:Norepinephrine