[Effect of 8-bromoadenine on DNA repair].
Effects of 8-bromoadenine have been investigated on the prereplicative and post-replicative processes of DNA repair in gamma-irradiated monolayer HeLa-M cells, a method of ultracentrifugation in alkaline sucrose gradients being used. A 30-90 minutes treatment of cells with 8-bromoadenine before irradiation (1, 5, 20 krad) distinctly inhibits the DNA single-strand break repair. The molecular weight of DNA, synthesized in gamma-irradiated cells in the presence of 8-bromoadenine, is less than that synthesized without 8-bromoadenine.
D000225:Adenine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D011836:Radiation Tolerance; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*
D011838:Radiation-Sensitizing Agents; C027055:8-bromoadenine; D000225:Adenine
Vliianie 8-bromadenina na reparatsiiu DNK.