[Mechanism of action of levamisole on cells of the mononuclear phagocytizing system].
The levamisole effect on the phagocytic capacity of macrophages and their membrane permeability was studied in A and CBA mice. It was shown that both in vivo and in vitro, levamisole treatment of peritoneal and splenic macrophages resulted in the diminution of antigen uptake and slowing down of its clearance as compared with control animals. The exposure to levamisole led to the enhanced membrane permeability and the decreased total cathepsin activity in the peritoneal cells and in their lysosomes.
D000818:Animals; D001202:Ascitic Fluid / Q000166:cytology; D004912:Erythrocytes / Q000276:immunology; D007425:Intracellular Membranes / Q000187:drug effects; D007978:Levamisole / Q000494:pharmacology*; D008247:Lysosomes / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects*; D051379:Mice; D008805:Mice, Inbred A; D008808:Mice, Inbred CBA; D010539:Permeability; D010587:Phagocytosis / Q000187:drug effects*; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology
D007978:Levamisole
O mekhanizme deĭstviia levamizola na kletki mononuklearnoĭ fagotsitiruiushcheĭ sistemy.