Multivariate analysis of an enzymic profile for the differential diagnosis of viral hepatitis.
Differential diagnosis of acute viral hepatitis, persistent chronic hepatitis, aggressive chronic hepatitis, and post-necrotic cirrhosis can reasonably be achieved on the basis of three well-known liver-function tests: aspartate aminotransferase, alanine aminotransferase, and glutamate dehydrogenase. With use of principal-component analysis, these four liver diseases can be characterized by two criteria: a "cytolytic" criterion, correlated particularly with a membrane-permeability test--namely, alanine aminotransferase activity--and a "mitochondrial damage" criterion, which is associated with above-normal ornithine carbamyltransferase and glutamate dehydrogenase activities.
D000410:Alanine Transaminase / Q000097:blood*; D001219:Aspartate Aminotransferases / Q000097:blood*; D004796:Clinical Enzyme Tests; D003937:Diagnosis, Differential; D005969:Glutamate Dehydrogenase / Q000097:blood*; D006525:Hepatitis, Viral, Human / Q000175:diagnosis*; D006801:Humans; D008099:Liver / Q000201:enzymology; D009954:Ornithine Carbamoyltransferase / Q000097:blood*
D005969:Glutamate Dehydrogenase; D009954:Ornithine Carbamoyltransferase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase