Kanamycin ototoxicity and pigmentation in the guinea pig.
Cochleas from albino and pigmented guinea pigs were examined histologically following chronic administration of Kanamycin. In pigmented animals, damage was concentrated amongst hair cells towards the base, but in albinos, hair cell damage was diffusely spread. These observations support suggestions that melanin is implicated in Kanamycin ototoxicity.
D000818:Animals; D006168:Guinea Pigs; D006198:Hair Cells, Auditory / Q000187:drug effects*; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects; D007612:Kanamycin / Q000494:pharmacology*; D012880:Skin Pigmentation
D007612:Kanamycin