title: [Combined effect of remantadine (alpha-methyl-1-adamantane methylamine) and ribovirin (1-beta-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) on the reproduction of Sindbis virus in cell culture].
abstract: The influence of remantadine, ribovirine, and combination thereof on Sindbis virus reproduction in cell cultures was studied. Comparison of remantadine and ribovirine showed the former to be a stronger inhibitor of Sindbis virus reproduction. The results of the combined effect of both drugs in chick embryo fibroblast cultures showed undoubtful advantages of this treatment over the use of each of the drugs alone. In studies of the effect of ribovirine on synthesis of virus-specific proteins and RNA no inhibition of formation of virus-specific macromolecules was observed.
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives*; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage*; D002478:Cells, Cultured; D002642:Chick Embryo; D005347:Fibroblasts; D066298:In Vitro Techniques; D012254:Ribavirin / Q000008:administration & dosage*; D012263:Ribonucleosides / Q000008:administration & dosage*; D012299:Rimantadine / Q000008:administration & dosage*; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D012263:Ribonucleosides; D012299:Rimantadine; D012254:Ribavirin; D000218:Adamantane
vernacular_title: Issledovanie kombinirovannogo deĭstviia remantadina (al'fa-metil-adamantanmetilamina) i ribovirina (1-beta-D-ribofuranozil-1,2,4-triazol-3-karboksamida) na reproduktsiiu virusa Sindbis v kul'ture kletok.