title: [Properties of the rabies virus long persisting in cell cultures].
abstract: Properties of rabies virus (RV) persisting in chronically infected cultures (CIC): HEp-2--RV and BHK-RV were studied. RV from the HEp-2-RV system retained its pathogenicity for mice for more than 3 years of observation. RV from the BHK-RV system lost this property after 50 passages in CIC. Both RV variants from CIC formed plaques in CER cells, showed marked immunogenic activity in mice, had no interferon-inducing activity in BHK-21 cells, and were not temperature-sensitive. Electron microscopic examinations of CIC culture fluids showed virions of bullet-like, oval, or spherical shapes.
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D008647:Mesocricetus; D051379:Mice; D011820:Rabies virus / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*; D013696:Temperature; D013997:Time Factors; D014762:Viral Interference; D010948:Viral Plaque Assay; D014776:Virus Cultivation; D014779:Virus Replication
vernacular_title: Svoĭstva virusa beshenstva, dlitel'no persistiruiushchego v kul'turakh kletok.