title: Rate measurements in cases of substrate inhibition.
abstract: Analysis of a simple model for substrate inhibition of an enzyme shows that the methods of Lee and Wilson (Lee, H.-J. and Wilson, I.B. (1971) Biochim. Biophys. Acta 242, 519--522), and Yun and Suelter (Yun, S.-L. and Suelter, C.H. (1977) Biochim. Biophys. Acta 480, 1--13), may be used to derive initial rate data from the sigmoidal-reaction progess curves that may be generated in such cases and in a number of instances, may be used to derive the kinetic parameters defining the rate equation from single-reaction progress curves.
mesh_terms: D004791:Enzyme Inhibitors; D007700:Kinetics; D008956:Models, Chemical
chemical_list: D004791:Enzyme Inhibitors