Diminished hepatic binding protein for desialylated glycoproteins during chemical hepatocarcinogenesis.
The lectin hepatic binding protein has a specific binding capacity for desialylated serum glycoproteins and is limited to hepatocyte membranes. This binding capacity was reduced by approximately 60% in the neoplastic nodules which resulted from exposure of rat livers to N-2-acetylaminofluorene. The binding capacity of the primary hepatocellular carcinomas which resulted from this regimen was reduced by 95%. The loss of binding capacity was found to be proportional to the decreased concentration of immunologically detectable lectin in the altered tissues.
D015073:2-Acetylaminofluorene; D000818:Animals; D000906:Antibodies / Q000032:analysis; D002352:Carrier Proteins / Q000032:analysis* / Q000276:immunology; D002462:Cell Membrane / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism*; D037102:Lectins / Q000032:analysis; D008099:Liver / Q000378:metabolism*; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000378:metabolism; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000378:metabolism; D009961:Orosomucoid / Q000378:metabolism; D051381:Rats
D000906:Antibodies; D002352:Carrier Proteins; D006023:Glycoproteins; D037102:Lectins; D009961:Orosomucoid; D015073:2-Acetylaminofluorene