Central noradrenergic adaptation to long-term treatment with imipramine in rhesus monkeys.
Rhesus monkeys were treated with the antidepressant drug imipramine; cerebrospinal fluid norepinephrine and dopamine-beta-hydroxylase were measured to assess central noradrenergic activity. Large changes occurred after short-term, but not long-term, treatment. Biochemical stabilization occurs at the time when therapeutic effects are seen in patients.
D000064:Acclimatization; D000818:Animals; D004299:Dopamine beta-Hydroxylase / Q000134:cerebrospinal fluid*; D007099:Imipramine / Q000494:pharmacology*; D007700:Kinetics; D008253:Macaca mulatta; D009638:Norepinephrine / Q000134:cerebrospinal fluid*
D004299:Dopamine beta-Hydroxylase; D007099:Imipramine; D009638:Norepinephrine