Mammary carcinogenesis in (C3H x RIII)F1 mice which receive the trans isomer of a brominated triphenylethylene.
The trans isomer of a bromotriphenylethylene (TBP) inhibits spontaneous mammary carcinogenesis in (C3H x RIII)F1 females, which received a diet containing 20 ppm of the chemical: intact, spayed, and spayed and pituitary implanted animals. Mammary carcinogenesis is inhibited even if the administration of the compound starts late in life. TBP has no activity on mammary carcinogenesis of castrated males implanted with an ovary.
D000818:Animals; D002369:Castration; D004965:Estrogen Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D007536:Isomerism; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000517:prevention & control*; D051379:Mice; D010902:Pituitary Gland / Q000502:physiology; D013267:Stilbenes / Q000494:pharmacology*
D004965:Estrogen Antagonists; D013267:Stilbenes; C002425:phenylstilbene bromide