Tissue threshold changes during the first months of immunotherapy.
The cutaneous, ocular and nasal sensitivity to ragweed extract was studied in seven patients during the early months of ragweed immunotherapy. Decreased skin sensitivity (p < 0.01) developed, as well as reduced conjunctival and nasal sensitivity. These changes correlated with the cumulative dose of extract administered and with levels of blocking antibody. However, there was no correlation between changes in tissue threshold and changes in ragweed specific IgE.
D000906:Antibodies; D001667:Binding, Competitive; D003228:Conjunctiva / Q000276:immunology*; D006801:Humans; D009297:Nasal Mucosa / Q000276:immunology*; D011852:Radioallergosorbent Test; D012220:Rhinitis / Q000628:therapy*; D012867:Skin / Q000276:immunology*; D012882:Skin Tests; D013997:Time Factors
D000906:Antibodies