The influence of sodium restriction on orthostatic sympathetic nervous activity.
To evaluate the influence of low-salt diet on the sympathetic nervous system activity, the adaptation to upright posture in five normal subjects was studied during normal salt and 10mEq sodium and 60-mEq potassium diets. On assuming upright posture, there were similar rises in pulse rate and diastolic blood pressure (BP) but a decline in systolic BP, during both diets. A prompt rise in plasma norepinephrine level during low-sodium diet was greater than during normal diet. Orthostatic response of the plasma epinephrine level was small, although significant, but unaffected by the diets. During normal-sodium diet, plasma renin activity response was delayed, but a prompt and enhanced response was observed during low-sodium diet. These data suggest that sodium deprivation enhances the sympathetic nervous system activity and the orthostatic stimulation of renin release.
D000328:Adult; D004837:Epinephrine / Q000097:blood; D006801:Humans; D008297:Male; D009638:Norepinephrine / Q000097:blood; D011187:Posture; D011188:Potassium / Q000652:urine; D012964:Sodium / Q000008:administration & dosage* / Q000652:urine; D013564:Sympathetic Nervous System / Q000502:physiology*
D012964:Sodium; D011188:Potassium; D009638:Norepinephrine; D004837:Epinephrine