Prenylamine-induced ventricular tachycardia and syncope controlled by ventricular pacing.
We describe eight patients treated for angina with prenylamine who developed life-threatening ventricular arrhythmias after QT interval prolongation. When prenylamine administration was stopped QT interval shortened to within normal values, while the ventricular arrhythmias were controlled by a temporary ventricular pacemaker and disappeared after several days. We stress the importance of surveillance of the QT interval and ventricular arrhythmias in patients receiving long-term treatment with prenylamine.
D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy; D002304:Cardiac Pacing, Artificial; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011299:Prenylamine / Q000009:adverse effects* / Q000627:therapeutic use; D013575:Syncope / Q000139:chemically induced; D013610:Tachycardia / Q000139:chemically induced* / Q000628:therapy
D011299:Prenylamine