title: Magnesium stearate given perorally to rats. A short term study.
abstract: Magnesium stearate was fed to groups of 20 male and 20 female rats at levels of 0, 5, 10 and 20% in a semisynthetic diet for 3 months. Decreased weight gain was found in males in the 20% group. Urolithiasis was found in 8 males and in 7 females in the same group. Reduced relative liver weight was seen in males in the 10% and in the 20% groups, and an increased amount of iron was found in the livers of the 20% group. Nephrocalcinosis was reduced in females in the 20% group. In this experiment the no-effect-level is estimated to be 5% magnesium stearate in the diet, corresponding to 2500 mg/kg body wt/day.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005260:Female; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D009397:Nephrocalcinosis / Q000139:chemically induced*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D012737:Sex Factors; D013228:Stearates / Q000633:toxicity*; D013229:Stearic Acids / Q000633:toxicity*; D014545:Urinary Calculi / Q000139:chemically induced*
chemical_list: D013228:Stearates; D013229:Stearic Acids