Ageing, a factor aggravating chronic toxicity of cadmium.
Two groups, each of 4 rabbits, 17 and 4 months old, respectively, were given s.c. administrations of cadmium (Cd) at a dose level of 0.5 mg/kg/day 6 times per week for up to 32 weeks. In 17-month-old rabbits, low-molecular-weight proteinuria appeared in the 3rd week, proteinuria, glycosuria and anemia in the 6th week; and all animals died by the 8th week. In 4-month-old rabbits, low-molecular-weight proteinuria and anemia appeared in the 6th--9th weeks, proteinuria, glycosuria and aminoaciduria by the 12th week; and all animals died by the 32nd week. The results suggest that ageing may aggravate the chronic toxicity of cadmium.
D000375:Aging; D000596:Amino Acids / Q000652:urine; D000818:Animals; D001835:Body Weight; D002104:Cadmium / Q000633:toxicity*; D003404:Creatinine / Q000652:urine; D004231:Diuresis / Q000187:drug effects; D006029:Glycosuria / Q000139:chemically induced; D006454:Hemoglobins / Q000378:metabolism; D008297:Male; D010758:Phosphorus / Q000378:metabolism; D011507:Proteinuria / Q000139:chemically induced; D011817:Rabbits
D000596:Amino Acids; D006454:Hemoglobins; D002104:Cadmium; D010758:Phosphorus; D003404:Creatinine