Hydralazine-induced liver injury.
A 68-year-old man developed hepatic injury with no hypersensitivity reaction after three years of hydralazine therapy. The liver injury histologically showed centrilobular zonal necrosis. Clinical, biochemical, and histological recovery followed discontinuation of the drug. Challenge tests and serial liver biopsies revealed that this liver injury was induced by hydralazine.
D000368:Aged; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis*; D006801:Humans; D006830:Hydralazine / Q000009:adverse effects*; D008099:Liver / Q000187:drug effects* / Q000473:pathology; D008111:Liver Function Tests; D008297:Male; D009336:Necrosis
D006830:Hydralazine