title: Effect of propranolol on the lower oesophageal sphincter in man.
abstract: The effect of an intravenous dose (2 mg) of propranolol in the lower oesophageal sphincter was studied in 10 human volunteers. A hydraulic-capillary infusion manometric technique was used to measure the lower oesophageal sphincter pressure. A significant increase in sphincter pressure was recorded, together with increased amplitude and duration of oesophageal peristaltic activity. This study confirms the presence of specific beta-receptors in the lower oesophageal sphincter.
mesh_terms: D000328:Adult; D004943:Esophagogastric Junction / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D010528:Peristalsis / Q000187:drug effects; D011433:Propranolol / Q000494:pharmacology*
chemical_list: D011433:Propranolol