A polymorphism of the gamma-chain of mouse C4 controlled by the S region of the major histocompatibility complex.
Three phenotypes of the gamma-chain of mouse C4 have been detected by a modification of the two-dimensional O'Farrell technique. Strains carrying the H-2s, H-2p, H-2f and H-2ja haplotypes had chains with pI 7.4 (gamma 1). Strains with H-2k, H-2q, H-2d, H-2r, H-2b, H-2u, and H-2w7 had gamma-chains with pI 6.9 (gamma 2), and strains carrying a wild-derived haplotype had gamma chains with pI 6.5 (gamma 3). The genes controlling this polymorphism were mapped in the S region of the H-2 complex by using congenic strains.
D000818:Animals; D002417:Cattle; D003181:Complement C4; D004591:Electrophoresis, Polyacrylamide Gel; D006183:H-2 Antigens / Q000235:genetics; D007525:Isoelectric Focusing; D008285:Major Histocompatibility Complex; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D008970:Molecular Weight; D011110:Polymorphism, Genetic; D011817:Rabbits
D003181:Complement C4; D006183:H-2 Antigens