Suppression of microfilaraemia in Litomosoides carinii infections in cotton rats by vaccination with adult worm homogenate.
Twenty cotton rats were injected with a homogentae of adult male and female Litomosoides carinii prepared by freeze-thawing the worms in phosphate-buffered-saline followed by mechanical treatment in a Potter-Elvejhma homogenizer. Intramuscular injections including Freund's complete adjuvant were made into rats which were subsequently quantitatively exposed to infection with L carinii in Liponyssus bacoti. There was no development of a microfilaraemia between 50 and 100 days post-infection in any of the 'vaccinated' cotton rats despite the presence of living adult male and female worms and microfilariae in the pleural cavity. In all the control animals and microfilaraemia developed which persisted for up to 100 days after infection.
D000818:Animals; D001769:Blood / Q000469:parasitology; D005368:Filariasis / Q000469:parasitology / Q000517:prevention & control*; D005370:Filarioidea; D008842:Microfilariae; D010994:Pleura / Q000469:parasitology; D051381:Rats / Q000469:parasitology*; D012376:Rodent Diseases / Q000517:prevention & control; D014611:Vaccination