Cutaneous cryptococcosis.
A 31-year-old woman with long-standing renal disease, treated with systemic steroids and azathioprine, developed progressive skin ulceration and subcutaneous nodules. A diagnosis of cryptococcosis was established after histological examination of a cutaneous lesion and confirmed by culture of the organism from the biopsy specimen. A detailed description of the histology and ultrastructure of the cutaneous lesion is presented. Treatment with parenteral amphotericin B and 5-fluorocytosine resulted in dramatic resolution of the skin lesions.
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D003453:Cryptococcosis / Q000188:drug therapy / Q000473:pathology*; D003881:Dermatomycoses / Q000188:drug therapy / Q000473:pathology*; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000627:therapeutic use; D006801:Humans; D012867:Skin / Q000648:ultrastructure
D000666:Amphotericin B; D005437:Flucytosine