[Various agents influencing lymphocyte chromosome aberrations observed in inflammatory diseases of connective tissue].
From chromosome breaks observed in lymphocyte culture of patients with auto-immune diseases, the authors study the factors favouring the onset of these breaks, (clastogenic factor and superoxide radicle) and those which appear able to reduce them (D-penicillamine and dismutase superoxide). The therapeutic implications of these findings will be the object of later publications.
D000818:Animals; D002869:Chromosome Aberrations; D002877:Chromosomes, Human / Q000187:drug effects; D003240:Connective Tissue Diseases / Q000235:genetics*; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*; D051379:Mice; D010396:Penicillamine / Q000494:pharmacology; D013482:Superoxide Dismutase / Q000494:pharmacology
D013482:Superoxide Dismutase; D010396:Penicillamine
Etude de quelques agents influençant les aberrations cheomosomiques lymphocytaires observées au cours des maladies inflammatoires du tissu conjonctif.