Mutagenesis and morphological transformation of mammalian cells by a non-bay-region polycyclic cyclopenta(cd)pyrene and its 3,4-oxide.
Cyclopenta(cd)pyrene, a constituent of environmental emissions, has been found to mutate and transform mammalian cells in culture. Cyclopenta(cd)pyrene 3,4-oxide, a presumed metabolite, was found to be a direct-acting mutagen and to transform mammalian cells. These results suggest that cyclopenta(cd)pyrene 3,4-oxide may be an ultimate mutagenic form of the parent hydrocarbon.
D000818:Animals; D002460:Cell Line; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D003517:Cyclopentanes / Q000494:pharmacology; D051379:Mice; D009153:Mutagens; D011721:Pyrenes / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D003517:Cyclopentanes; D009153:Mutagens; D011721:Pyrenes; C016328:cyclopenta(c,d)pyrene; C027599:cyclopenta(cd)pyrene 3,4-oxide