[Adjuvant chemotherapy of human colorectal adenocarcinoma after growth on mice with congenital thymic dysplasia ("nude"). 1. Experiments to test the feasibility of combined chemotherapy with VCR and 5-FU  (author's transl)].
Five-week-old syngeneic, female BALB/c nude mice were injected i.p. with vincristine (VCR) and 5-fluorouracil (5-FU) to determine the LD 20 of these drugs under spf-conditions. One hundred fifty animals were given dosages similar to those administered clinically, and a complete autopsy was performed on all nude mice. Whereas VCR caused splenic atrophy and regressive changes in the jejunal epithelium, the application of 5-FU was followed mainly by regressive changes in the transitional epithelium of the bladder, and 67% of the animals developed pneumonia. These pathohistological changes were also seen after a combined chemotherapy, and a temporary leucopenia was reversible. These experiments showed that chemotherapy of nude mice with VCR and 5-FU is possible provided they have been successfully xenotransplanted with human colorectal adenocarcinomas.
D000230:Adenocarcinoma / Q000188:drug therapy*; D000818:Animals; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D051379:Mice; D008819:Mice, Nude; D009374:Neoplasms, Experimental / Q000188:drug therapy; D012004:Rectal Neoplasms / Q000188:drug therapy*; D014750:Vincristine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
D014750:Vincristine; D005472:Fluorouracil
Adjuvante Chemotherapie humaner kolorektaler Adeno-Carcinome nach Wachstum auf kongenital thymusdysplastischen Mäusen "nude". 1. Untersuchungen zur Durchführbarkeit einer zytostatischen Kombinationstherapie mit Vincristin (VCR) und 5-Fluorouracil (5-FU).