[Participation of lipid radicals and active oxygen forms in the peroxidation of microsomal membrane lipids induced by organic hydroperoxides].
The peroxidative radicals arizing after destruction of exogenous hydroperoxides catalyzed by cytochrome P-450, carried out important functions in induction of lipid peroxidation, dependent on organic hydroperoxides. Only a slight inhibitory effect of singlet oxygen and anion radicals of superoxide on organic hydroperoxide dependent process of lipid peroxidation suggested that these active forms of oxygen participated apparently in lipid peroxidation. The traps of hydroxyl radicals (.OH) did not affect the lipid peroxidation induced by organic hydroperoxides. A mechanism is discussed for generation and function of peroxidative radicals as well as of active oxygen forms in lipid peroxidation, induced by organic hydroperoxides in liver microsomal membranes.
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D005609:Free Radicals; D007700:Kinetics; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D008563:Membrane Lipids / Q000378:metabolism*; D008862:Microsomes, Liver / Q000187:drug effects* / Q000378:metabolism; D010084:Oxidation-Reduction / Q000187:drug effects; D010101:Oxygen Consumption / Q000187:drug effects*; D010545:Peroxides / Q000494:pharmacology*; D051381:Rats
D005609:Free Radicals; D008054:Lipid Peroxides; D008563:Membrane Lipids; D010545:Peroxides; D003577:Cytochrome P-450 Enzyme System
Uchastie perekisnykh radikalov i aktivnykh form kisloroda v perekisnom okislenii lipidov mikrosomal'nykh membran, indutsiruemom organicheskimi gidroperekisiami.