Mechanism of the phosphaturia due to chlorothiazide.
CTZ caused a phosphaturia when baseline phosphate excretion was not already high. Furthermore, when th influence of PTH is withdrawn, the excretion of phosphate appears to be largely affected by changes in urinary pH.
D000818:Animals; D001639:Bicarbonates / Q000652:urine; D002740:Chlorothiazide / Q000494:pharmacology*; D004285:Dogs; D006863:Hydrogen-Ion Concentration; D010710:Phosphates / Q000652:urine*; D013965:Thyroidectomy
D001639:Bicarbonates; D010710:Phosphates; D002740:Chlorothiazide