A pharmacological and behavioural study on beta, beta'-iminodipropionitrile (IDPN)-treated brine shrimp Artemia salina L.
The neurotoxic substance beta, beta-iminodipropionitrile (IDPN), which induces hyperkinesia in some mammals, was found to be neurotoxic to the brine shrimp Artemia salina L. (Crustacea, Anostraca) inducing discoordination of limb-movement and sedation of motility. Up to 9 metabolities of IDPN were detected in Artemia, including beta-alanine, cyanoacetic acid, and beta-aminopropionitrile (BAPN). Brine shrimp, especially nauplius (1 day), may be a useful test animal for the biological assay of IDPN.
D000375:Aging; D000818:Animals; D001156:Artemia / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects*; D009570:Nitriles / Q000494:pharmacology*
D009570:Nitriles; C008110:3,3'-iminodipropionitrile