title: [5'-deoxy-5-fluoruridine, a new antineoplastic pyrimidine antimetabolite].
abstract: 5'-deoxy-5-fluorouridine (5-DFUR) exerts a marked cytostatic activity, both intraperitoneally and orally, against experimental tumors. It has a strong antitumor effect on the Crocker sarcoma S 180, the Lewis lung carcinoma and a chemically induced squamous cell carcinoma of the skin. Its ratio of antitumor activity toxicity is more favourable than that of 5-fluorouracil, 2'-deoxy-5-fluorouridine and 1-(2-tetra-hydrofuryl)-5-fluorouracil. Mode of action and reasons for the favourable therapeutic ratio are discussed.
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy; D005472:Fluorouracil / Q000031:analogs & derivatives*; D008175:Lung Neoplasms / Q000188:drug therapy; D051379:Mice; D011743:Pyrimidines; D012510:Sarcoma 180 / Q000188:drug therapy*; D012878:Skin Neoplasms / Q000188:drug therapy
chemical_list: D000964:Antimetabolites, Antineoplastic; D011743:Pyrimidines; D005472:Fluorouracil
vernacular_title: 5'-Desoxy-5-Fluoruridin (5-DFUR), ein neuer tumorhemmender Pyrimidin-Antimetabolit.