title: Effects of 5-iminodaunorubicin on nucleoli of rats.
abstract: We have confirmed that doxorubicin induces irreversible changes in the nucleolar ultrastructure of myocardial cells of rats. Similar changes were not caused by an equal dose of the synthetic analogue, 5-iminodaunomycin. These results combined with previous and current comparative tests with this analogue, doxorubicin, and daunomycin suggest that 5-iminodaunomycin may serve as a less cardiotoxic anthracycline derivative.
mesh_terms: D000818:Animals; D002466:Cell Nucleolus / Q000187:drug effects* / Q000648:ultrastructure; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D008099:Liver / Q000648:ultrastructure; D008297:Male; D009206:Myocardium / Q000648:ultrastructure; D051381:Rats
chemical_list: C018979:5-iminodaunorubicin; D003630:Daunorubicin