Hydrogen peroxide formation in the rat uterus under hormone-induced conditions.
The production of hydrogen peroxide was quantitated in the uterus of cyclic, ovariectomized (treated with hormones) and pregnant (days 1-6 post coitum) rats. This phenomenon was found to be dependent on oestrogen. The uterine responsiveness to hydrogen peroxide was correlated with peroxidase-catalysed inactivation of oestrogens in this target organ.
D000818:Animals; D002369:Castration; D004958:Estradiol / Q000494:pharmacology*; D004971:Estrus; D005260:Female; D006861:Hydrogen Peroxide / Q000378:metabolism*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D014599:Uterus / Q000187:drug effects / Q000378:metabolism*
D011374:Progesterone; D004958:Estradiol; D006861:Hydrogen Peroxide