Estrogen-like effects of O,P'-DDT on the progesterone receptor of rat uterine cytosol.
Uterine cytosolic progesterone binding in ovariectromized mature rats, treated with 10mg o,p'-DDT, 1.0microgram estradiol or vehicle, was examined by a dextran-coated charcoal method and sucrose gradient density analysis. Increases in progesterone binding capacities in o,p'-DDT and estradiol treated groups were demonstrated. The characteristics of the progesterone binding component were comparable to those of progesterone receptors in rat uteri.
D000818:Animals; D003600:Cytosol / Q000378:metabolism; D003634:DDT / Q000494:pharmacology*; D004958:Estradiol / Q000494:pharmacology; D004968:Estrogens, Non-Steroidal; D005260:Female; D066298:In Vitro Techniques; D007700:Kinetics; D009929:Organ Size / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D011980:Receptors, Progesterone / Q000187:drug effects*; D014599:Uterus / Q000378:metabolism*
D004968:Estrogens, Non-Steroidal; D011980:Receptors, Progesterone; D004958:Estradiol; D003634:DDT