Hypercholesterolaemia and hypertriglyceridaemia in patients with analgesic nephropathy.
Patients with analgesic nephropathy are reported to have a higher risk of atherosclerosis. One possible reason for this is a high incidence of hyperlipaemia in patients with analgesic nephropathy. In a retrospective study, serum cholesterol and serum triglyceride concentrations of patients with analgesic nephropathy and moderately restricted renal function were significantly higher compared to a control group with other renal diseases of similar age and degree of renal insufficiency. Hyperlipaemia in analgesic nephropathy is not explained by end-stage renal failure on one side or protein loss as in nephrotic syndrome on the other side. Some possible mechanisms for hyperlipaemia in analgesic nephropathy are discussed.
D000328:Adult; D000368:Aged; D000700:Analgesics / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000209:etiology*; D006949:Hyperlipidemias / Q000209:etiology*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000150:complications*; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010615:Phenacetin / Q000009:adverse effects; D012189:Retrospective Studies; D014280:Triglycerides / Q000097:blood*
D000700:Analgesics; D008074:Lipoproteins; D014280:Triglycerides; D010615:Phenacetin