The recombinant inbred strains: a tool for the genetic analysis of differences observed in the self-stimulation behaviour of the mouse.
The self-stimulation behaviour (ICSS) in the lateral hypothalamus of mice was studied using 5 recombinant inbred strains having the DBA/2 and BLAB/c lines for their parental origin. Two of these recombinant inbred strains behave like the recessive parental line (BALB/c) while the three others have a performance level similar to that of the dominant (DBA/2) parent. This division suggests that there is a major gene which determines the difference in performance between the two parental lines. The mean value for the self-stimulation threshold is negatively correlated with the value of the performance. The sensitivity to convulsions, which interrupt ICSS behaviour above certain current intensities, is under the control of a genetic determinant independent, but more complex, than the one which controls the level of performance.
D000818:Animals; D003433:Crosses, Genetic; D004558:Electric Stimulation; D005260:Female; D005796:Genes; D005824:Genetics, Behavioral; D007031:Hypothalamus / Q000502:physiology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000235:genetics*; D008811:Mice, Inbred DBA / Q000235:genetics*; D011995:Recombination, Genetic; D012640:Seizures / Q000235:genetics; D012653:Self Stimulation / Q000502:physiology*