The effects of scorpion venom tityustoxin and ouabain on the release of acetylcholine from incubated slices of rat brain.
The in vitro release of acetylcholine in slices of rat brain tissue was followed in the presence of tityustoxin and ouabain. At low ouabain concentrations, the release of acetylcholine caused by both ouabain and tityustoxin, was additive. At higher ouabain concentrations the additive effect of tityustoxin and ouabain on the release of ACh was no longer observed.
D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D010042:Ouabain / Q000494:pharmacology*; D051381:Rats; D012604:Scorpion Venoms / Q000494:pharmacology*
D012604:Scorpion Venoms; D010042:Ouabain; D000109:Acetylcholine