Use of dopamine and prazosin combined in the treatment of cardiogenic shock.
Seventeen patients who developed cardiogenic shock after acute myocardial infarction were treated with intravenously infused dopamine. In eight of these patients a stable blood pressure was attained, but oliguria or anuria persisted, and oral treatment with prazosin was instituted. Diuresis occurred in seven of these patients, but was followed by transient hypotension associated with a rapid rise in plasma prazosin levels in three. Four patients left hospital, and there were two long-term survivors. Prazosin may be a useful adjunct to dopamine in the treatment of cardiogenic shock.
D000284:Administration, Oral; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects; D004298:Dopamine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D011224:Prazosin / Q000008:administration & dosage* / Q000494:pharmacology; D011799:Quinazolines / Q000008:administration & dosage*; D012770:Shock, Cardiogenic / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine
D011799:Quinazolines; D004298:Dopamine; D011224:Prazosin