Spontaneous fibro-osseous lesions in aging female mice.
Fibrous tissue and occasionally bony trabeculae replaced part of the marrow cavity in the sternebrae of aging mice. These lesions were observed in 99 of 228 females and only 1 of 226 males. The pathogenesis of the lesions was not determined.
D000375:Aging; D000818:Animals; D001847:Bone Diseases / Q000473:pathology / Q000662:veterinary*; D001853:Bone Marrow / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D005260:Female; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains / Q000502:physiology; D012376:Rodent Diseases / Q000473:pathology*; D012737:Sex Factors