title: Do neostigmine and 4-aminopyridine inhibit the antibacterial activity of antibiotics?
abstract: Neostigmine and 4-aminopyridine are used to antagonize the neuromuscular blockade induced by antibiotics or an antibiotic-non depolarizing blocker combination. They may also counteract the antibacterial activity of antibiotics. It was found that neostigmine and 4-aminopyridine do not interfere with antibacterial activity of antibiotics in bacterial cultures using an agar solution method. It is concluded that neostigmine and 4-aminopyridine may bae used to antagonize neuromuscular blockade induced by antibiotics alone or in combination with non-depolarizing agents.
mesh_terms: D015761:4-Aminopyridine; D000631:Aminopyridines / Q000494:pharmacology*; D000900:Anti-Bacterial Agents / Q000037:antagonists & inhibitors*; D001419:Bacteria / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D009388:Neostigmine / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects
chemical_list: D000631:Aminopyridines; D000900:Anti-Bacterial Agents; D009388:Neostigmine; D015761:4-Aminopyridine