title: Tissue specificity of the epididymal androgen dependent phospholipase A.
abstract: The effect of androgens on phospholipase A in the rat epididymis, liver, heart, kidney, prostate and epididymal fat pad has been investigated both in the cytosol and in a postmitochondrial particulate cell fraction. In both cell fractions, phospholipase A activity was 10-15 times higher in the cauda epididymidis than in the other organs, including the caput epididymidis, while the corpus showed an intermediate activity. In the cauda and corpus, castration reduced phospholipase A activity in both subcellular fractions to the same level as found in the other organs, and testosterone supplementation restored the enzyme activity. No evidence of a similar androgen controlled phospholipase A was found in any other tissue examined, including the prostate.
mesh_terms: D000818:Animals; D002369:Castration; D004822:Epididymis / Q000201:enzymology*; D008244:Lysophosphatidylcholines / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D010740:Phospholipases / Q000378:metabolism*; D010741:Phospholipases A / Q000302:isolation & purification / Q000378:metabolism*; D051381:Rats; D013739:Testosterone / Q000378:metabolism*
chemical_list: D008244:Lysophosphatidylcholines; D013739:Testosterone; D010740:Phospholipases; D010741:Phospholipases A