[Effect of glutamate on the kinetics of sodium metabolism in slices of rat neocortex and hippocampus].
Three kinetic compartments (one extra--and two intracellular) of Na were distinguished in the rat neocortical and hippocampal cuts. Glutamate (Glu) caused the increase of intracellular Na compartments via two mechanisms: by the elevation of Na influx rate constant and by the decrease of Na efflux rate constant. The relationship between the phenomena observed and possible transmitter action of the Glu is discussed.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects; D005110:Extracellular Space / Q000378:metabolism; D005971:Glutamates / Q000494:pharmacology*; D006624:Hippocampus / Q000378:metabolism*; D066298:In Vitro Techniques; D007424:Intracellular Fluid / Q000378:metabolism; D007700:Kinetics; D008297:Male; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013003:Somatosensory Cortex / Q000378:metabolism*
D005971:Glutamates; D012964:Sodium
Vliianie glutamata na kinetiku obmena natriia v srezakh novoĭ kory i gippokampa krys.