[Mechanism of heparin binding by polycations in the presence of serum proteins].
Mechanism of heparin interaction with the soluble complexes polyacrylamide (PA)--protein fractions of the whole serum has been examined. Addition of heparin to a mixture of the soluble complexes serum proteins (SP)--PA gives rise to the macromolecular reaction of protein replacement by negatively charged polysaccharide (heparin) according to the following scheme: (PA)--SP complex) plus heparin in equilibrium or formed from (PA--heparin complex) pus SP. Succession has been studied of heparin removal of different proteins from their polycation-including soluble complexes.
D001797:Blood Protein Electrophoresis; D001798:Blood Proteins / Q000032:analysis / Q000378:metabolism*; D001799:Blood Sedimentation; D004347:Drug Interactions; D004591:Electrophoresis, Polyacrylamide Gel; D006493:Heparin / Q000097:blood*; D006494:Heparin Antagonists; D066298:In Vitro Techniques; D046911:Macromolecular Substances; D011145:Polyvinyls / Q000097:blood*; D011485:Protein Binding / Q000187:drug effects; D012995:Solubility
D001798:Blood Proteins; D006494:Heparin Antagonists; D046911:Macromolecular Substances; D011145:Polyvinyls; C027968:poly-4-vinyl-N-ethylpyridine; D006493:Heparin
O mekhanizme sviazyvaniia geparina polikationami na fone syvorotochnykh belkov.