Close linkage between the C blood group locus and the locus controlling amino acid transport in sheep erythrocytes.
Data from 838 Finnish Landrace or Finnish Landrace crossbred sheep showed a highly significant correlation between phenotypes of the C blood group system and erythrocyte amino acid transport variants. Erythrocytes with normal amino acid transport properties (GSH high, Ly- type) were Cb-positive or Cb-negative. Erythrocytes with the amino acid transport lesion (GSH low, Ly +) were never Cb-negative. Sheep erythrocytes homozygous for Cb showed stronger lysis reactions with anti-Cb than heterozygous cells. Ly + sheep were nearly always homozygous for Cb, whereas most Ly- sheep were heterozygous for Cb-negative. Inheritance studies provided strong evidence that this association is due to close genetic linkage.
D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D001692:Biological Transport; D001789:Blood Group Antigens / Q000235:genetics*; D003433:Crosses, Genetic; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D008040:Genetic Linkage; D008297:Male; D010641:Phenotype; D011995:Recombination, Genetic; D012756:Sheep / Q000097:blood / Q000235:genetics*
D000596:Amino Acids; D001789:Blood Group Antigens