[Animal behavioral reactions, adrenocortical activity and brain energy metabolism under the action of propylnorantifein].
Behavioral reactions induced in white rats by propylnorantifein were studied by the tests of an open field, passive avoidance and self-stimulation from the medial bundle of the fore brain and Raffe suture. Biochemical analysis was done on the content of corticosteroids in blood plasma and that of glycogen and creatine phosphate in brain tissue. Propylantifein in a dose of 5 mg/kg was shown to decrease the self-stimulation, to change the emotional memory in response to pain stimulation, to increase the concentration of corticosteroids in blood plasma. During 3 hr after the drug administration brain tissue demonstrated the decreased glycogen content and particular, drastically reduced the drug action. It is suggested that propylantifein may activate the adenylcyclase system in brain tissue.
D000302:Adrenal Cortex / Q000187:drug effects*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D004347:Drug Interactions; D004644:Emotions / Q000187:drug effects; D004734:Energy Metabolism / Q000187:drug effects*; D005042:Etimizol / Q000031:analogs & derivatives / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D010643:Phenoxybenzamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012653:Self Stimulation / Q000187:drug effects
D003998:Dicarboxylic Acids; D007093:Imidazoles; D010643:Phenoxybenzamine; C026619:propylnorantifein; D011433:Propranolol; D005042:Etimizol
Povedencheskie reaktsii, adrenokortikal'naia aktivnost' i énergeticheskiĭ obmen golovnogo mozga zhivotnykh pri deĭstvii propilnorantifeina.