Sexual dimorphism in binding and metabolism of cortisol during puberty in the guinea pig.
Sexual difference in plasma cortisol levels appeared in basal conditions on day 30 post-partum and values remained significantly higher in female guinea-pigs until day 70, disappearing on days 90 and 120. After stress, plasma cortisol levels increased in both sexes and the dimorphism was conserved with lower values obtained in males. Between days 30 and 70, cortisol metabolic clearance rate was significantly higher and binding capacity of transcortin for cortisol was significantly lower in males than in female guinea-pigs.
D000375:Aging; D000818:Animals; D005260:Female; D006168:Guinea Pigs / Q000502:physiology*; D006854:Hydrocortisone / Q000097:blood* / Q000378:metabolism; D008297:Male; D012709:Serum Albumin / Q000378:metabolism; D012737:Sex Factors; D012741:Sexual Maturation; D014156:Transcortin / Q000378:metabolism
D012709:Serum Albumin; D014156:Transcortin; D006854:Hydrocortisone