title: Dose dependence of the excretion of maneb metabolites in urine of rats.
abstract: 14C-activity in the urine of female rats appeared to be independent of dose when single oral doses of [14C]maneb, a fungicide, manganese ethylene-bis(dithiocarbamate), were given. This was found with [14C]maneb synthesized from [U-14C]ethylenediamine. In the dose range, 23 microgram/kg to 1.4 g/kg of maneb, the excreted activity in urine of 39 female rats was 48.8 +/- 12.6% (n=39).
mesh_terms: D000042:Absorption; D000818:Animals; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000032:analysis; D005260:Female; D008344:Maneb / Q000652:urine*; D051381:Rats; D013859:Thiocarbamates / Q000652:urine*
chemical_list: D013859:Thiocarbamates; D008344:Maneb