Examination of naturally occurring polyacetylenes and alpha-terthienyl for their ability to induce cytogenetic damage.
alpha-Terthienyl and 5 polyacetylenes were examined for chromosome damaging activity using Syrian hamster cells. None of these naturally occurring compounds induced sister chromatid exchanges and neither alpha-terthienyl nor phenylheptatriyne induced chromosome aberrations.
D000114:Acetylene / Q000031:analogs & derivatives* / Q000494:pharmacology; D000480:Alkynes / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations / Q000187:drug effects*; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D007621:Karyotyping; D007668:Kidney; D008647:Mesocricetus; D008677:Metaphase / Q000187:drug effects; D011108:Polymers / Q000494:pharmacology*; D053279:Polyynes; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000494:pharmacology*
D000480:Alkynes; D011108:Polymers; D013876:Thiophenes; C019101:alpha-terthienyl; D053279:Polyynes; D000114:Acetylene