Another look at acute tolerance to thiopentone.
The phenomenon of "acute tolerance" to thiopentone was re-examined in 82 subjects with induction doses of 2-15mg kg-1. There was a strong positive correlation between the venous plasma thiopentone concentrations on recovery from anesthesia and the induction dose, expressed as either mg kg-1 or mg m-2. Recovery time was proportionately shorter with larger doses, being directly related to log10 of the plasma concentration at awakening.
D000771:Anesthesia, Intravenous; D004334:Drug Administration Schedule; D004361:Drug Tolerance; D006801:Humans; D013874:Thiopental / Q000008:administration & dosage* / Q000097:blood; D013997:Time Factors
D013874:Thiopental