Prader-Willi syndrome and a bisatellited derivative of chromosome 15.
A de nova bistaellited derivative of chromosome 15, inv dup (15) (pter leads to q11 or 12::p11 or q11 or 12 leads to pter), was identified by multiple banding techniques in a patient with Prader-Willi syndrome. A comparison of familial no. 15 short arm polymorphisms indicated that the extra chromosome was the result of a non-sister chromatid exchange between the paternal no. 15 homologs prior to or during meiosis.
D000293:Adolescent; D002871:Chromosome Banding; D002901:Chromosomes, Human, 13-15; D006801:Humans; D008297:Male; D011218:Prader-Willi Syndrome / Q000235:genetics*; D012854:Sister Chromatid Exchange