Production of rhodomycins in Streptomyces griseoruber 4620.
The strain Streptomyces griseoruber 4620 produces, besides the anthracycline antibiotics beromycins, some other anthracyclines of the rhodomycin type. Twelve isolates exhibiting a higher antibiotic activity (up to 2.5X), as compared to the parent strain, were obtained after a spontaneous selection. The following species were isolated from the hydrolysate of mycelial extract: beta-rhodomycinone, beta-isorhodomycinone, alpha 2-rhodomycinone, epsilon-rhodomycinone and 10-deoxy-beta-rhodomycinone, which has not yet been described.
D018943:Anthracyclines; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000302:isolation & purification; D009279:Naphthacenes / Q000096:biosynthesis* / Q000302:isolation & purification; D013302:Streptomyces / Q000378:metabolism*
D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D009279:Naphthacenes; C004977:rhodomycin