[Combination therapy of porphyria cutanea tarda using chloroquine and bloodletting therapy].
14 patients with PCT were treated with phlebotomy combined with Chloroquine. 4 venesections were performed before Chloroquine-treatment administered intermittently twice weekly. The so-called flu-syndrome manifested itself in the majority of patients. The clinical symptoms of PCT regressed within 6 weeks to 4 months of treatment, and the urinary uroporphyrin excretion returned to normal within 6 weeks to 3 months. Besides the flu-syndrome no side-effects could be observed. There has been a clinical and biochemical remission for a year and a half in each case but one. Relapse occurred in one case only one year after treatment.
D000328:Adult; D000368:Aged; D001815:Bloodletting; D002738:Chloroquine / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D011164:Porphyrias / Q000188:drug therapy / Q000628:therapy* / Q000652:urine
D002738:Chloroquine
Kombinationsbehandlung der Porphyria cutanea tarda (PCT) mit Chloroquine und Aderlasstherapie.