Nuclear magnetic resonance relaxation times for tissues of mice given radioprotective compounds.
The pharmacological actions of chemical radioprotective substances (superoxide dismutase, cysteamine, beta-aminoethylisothiouronium Br-HBr, and propylene glycol) on mouse tissues were studied by measurement of proton NMR relaxation times. Changes in 1/T1 and 1/T2 values were observed but could not be correlated in any simple manner with the radioprotective actions of the administered compounds. Small but statistically significance correlations between water content and 1/T1 or 1/T2 value were observed.
D000818:Animals; D001834:Body Water / Q000378:metabolism; D003543:Cysteamine / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D011409:Propylene Glycols / Q000494:pharmacology; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013482:Superoxide Dismutase / Q000494:pharmacology; D000338:beta-Aminoethyl Isothiourea / Q000494:pharmacology
D011409:Propylene Glycols; D011837:Radiation-Protective Agents; D000338:beta-Aminoethyl Isothiourea; D003543:Cysteamine; D013482:Superoxide Dismutase