Simplex search in optimization of capsule formulation.
The simplex method of optimization was applied to a capsule formulation uing the dissolution rate and compaction rate as the desired responses to be optimized. The formulation parameters investigated included the levels of drug, disintegrant, lubricant, and fill weight. Following the successful optimization of the capsule formulation, the accumulated data were fitted to a polynomial regression model to plot response surface maps around the optimum.
D002214:Capsules; D002626:Chemistry, Pharmaceutical; D008433:Mathematics; D012044:Regression Analysis; D012995:Solubility; D013499:Surface Properties
D002214:Capsules