title: The effect of overnight biliary drainage on the hepatic excretion of bromosulphophthalein.
abstract: The excretion of bromosulphophthalein (BSP) was studied in rats after depletion of their bile salt pool by overnight biliary drainage. Peak biliary BSP excretion was significantly lower (80% of control value) in animals with a depleted bile salt pool; however, treatment with phenobarbital for 5 days before bile salt depletion prevented a reduction in BSP excretion. These studies support the observation that the hepatic excretion of bile salt is an important factor influencing the biliary excretion of BSP.
mesh_terms: D000818:Animals; D001647:Bile Acids and Salts / Q000032:analysis; D001652:Bile Ducts / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D051381:Rats; D013448:Sulfobromophthalein / Q000378:metabolism*; D013997:Time Factors
chemical_list: D001647:Bile Acids and Salts; D013448:Sulfobromophthalein