Kinetics of sulphafurazole in undernutrition.
1 An oral dose of 75 mg/kg body weight was used to study the kinetics of sulphafurazole in wellnourished and undernourished adult subjects. 2 There were no differences in the half-life, volume of distribution and total body clearance of the drug in the two groups of subjects. 3 The plasma protein binding of sulphafurazole was significantly reduced in the undernouished subjects. 4 It is concluded that alternations in the dosage schedule may not be necessary in the treatment of undernourished adults with sulphafurazole.
D000328:Adult; D001798:Blood Proteins / Q000378:metabolism; D006207:Half-Life; D006801:Humans; D007700:Kinetics; D008297:Male; D009748:Nutrition Disorders / Q000378:metabolism*; D011485:Protein Binding; D013444:Sulfisoxazole / Q000378:metabolism*
D001798:Blood Proteins; D013444:Sulfisoxazole