Ventricular wall thickness: a predictor of response to vasodilators in cardiomyopathy.
The effect of chronic adjunctive vasodilator therapy was assessed in 14 symptomatic patients with idiopathic cardiomyopathy. Thirteen of the 14 patients improved by one or more in the New York Heart Association functional class, one remained unchanged. Three became asymptomatic (class I). Noninvasive and invasive (hemodynamic) parameters before and after vasodilators were assessed. The echocardiographic findings of septal and posterior wall thickness of 1.2 cm or greater were the best predictors of good response in our patients who subsequently became asymptomatic.
D000284:Administration, Oral; D000328:Adult; D009202:Cardiomyopathies / Q000188:drug therapy*; D005500:Follow-Up Studies; D006352:Heart Ventricles / Q000033:anatomy & histology*; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006830:Hydralazine / Q000627:therapeutic use; D007548:Isosorbide Dinitrate / Q000627:therapeutic use; D008875:Middle Aged; D011379:Prognosis; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D014665:Vasodilator Agents; D006830:Hydralazine; D007548:Isosorbide Dinitrate