title: Hyperaldosteronism, hyperparathyroidism, medullary sponge kidneys, and hypertension.
abstract: Hyperparathyroidism and hyperaldosteronism coexisted in association with medullary sponge kidneys in a 27-year-old woman with severe hypertension. A modest fall in systolic and diastolic pressure followed removal of a parathyroid adenoma. Blood pressure was controlled with spironolactone therapy and restored to normal after removal of an aldosterone-secreting adrenal tumor. Elevated levels of aldosterone may have been responsible for the severe hypertension, while hypercalcemia may have had a synergistic effect on the arteriolar response to circulating vasoactive peptides.
mesh_terms: D000236:Adenoma / Q000378:metabolism; D000328:Adult; D000450:Aldosterone / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications*; D006961:Hyperparathyroidism / Q000150:complications*; D006973:Hypertension / Q000209:etiology*; D007679:Kidney Medulla / Q000473:pathology; D007691:Medullary Sponge Kidney / Q000150:complications*; D010282:Parathyroid Neoplasms / Q000378:metabolism; D013148:Spironolactone / Q000494:pharmacology
chemical_list: D013148:Spironolactone; D000450:Aldosterone