title: Febrile convulsions in inbred strains of mice susceptible and resistant to audiogenic seizures.
abstract: The incidence of febrile convulsions was determined in six inbred strains of mice at four ages. Febrile convulsions were elicited by placing the mice in a cylinder with the air temperature raised to 51 +/- 2 degrees C; this elevated the mouse's body and brain temperature to between 40 and 46 degrees C. The strains used were DBA/2Bg, DBA/1Bg, DBA/1Bg-ras, C57BL/10Bg, C57BL/6Bg, and C57BL/6Bg-Gad-1 alpha; the ages were 21 +/- 1, 29 +/- 1, 59 +/- 1, and 119 +/- 1 days of age. DBA/2Bg, DBA/1Bg, and C57BL/6Bg-Gad 1 alpha are audiogenic seizure susceptible at 21 +/- 1 and 29 +/- 1 days of age, but not at 59 +/- 1 and 119 +/- 1 days of age; whereas C57BL/10Bg, C57BL/6Bg, and DBA/1Bg-ras are audiogenic seizure resistant at all ages. Mice of both sexes, all strains, and all ages had a febrile convulsion and died. Thus, in inbred mice, there does not appear to be either a genetic or developmental correlation between audiogenic seizures and febrile convulsions. This finding may be contrasted with that in other studies showing a correlation between susceptibility to audiogenic seizures and to either electroshock convulsions or chemoconvulsions. However, there are subtle strain and age variants in susceptibility to febrile convulsions of these mice.
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001833:Body Temperature Regulation; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009154:Mutation; D012640:Seizures / Q000235:genetics*