Urinary excretion of catecholamines and metabolites in the Lyon strain of genetic hypertensive rats.
Urinary catecholamines (Norepinephrine : NE, Epinephrine : E) methoxylated amines (Metanephrine : MN, Normetanephrine : NMN) and 3-methoxy-4-hydroxyphenylglycol (MHPG) have been studied in the Lyon hypertensive strain of rats (LHS) and their normotensive controls (LNS) at three ages (5, 9 and 21 weeks) characteristic of the development of hypertension. In 5-week-old rats, increased excretion of E, MN, NMN and early elevation of the ratio E/E+NE were observed, thus suggesting a sympatho-adrenal hyperactivity, with accelerated maturation of E secretion. At adult age, the excretion of most adrenergic metabolites was similar in the two strains of rats. However, the data from adult LHS are difficult to interpret because of a potential renal impairment at this age. Furthermore, there was a positive correlation between systolic blood pressure and urinary catecholamines at 5 weeks and 9 weeks of age but not at 21 weeks. It is suggested that the early sympathoadrenal hyperactivity, which disappears with age, may be related to the onset of hypertension in the Lyon strain of hypertensive rats.
D000311:Adrenal Glands / Q000503:physiopathology; D000375:Aging; D000818:Animals; D001794:Blood Pressure; D003404:Creatinine / Q000652:urine; D004837:Epinephrine / Q000652:urine*; D006018:Glycols / Q000652:urine*; D006973:Hypertension / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000652:urine*; D009638:Norepinephrine / Q000652:urine*; D051381:Rats
D006018:Glycols; D008734:Methoxyhydroxyphenylglycol; D003404:Creatinine; D009638:Norepinephrine; D004837:Epinephrine