Effects of N-trifluoroacetyl adriamycin-14-valerate (AD32) on nuclear RNA synthesis in cultured L1210 cells.
N-Trifluoroacetyl adriamycin-14-valerate (AD32), an analog of adriamycin, inhibits nuclear RNA synthesis. It inhibits rRNA, non-poly(A) hnRNA and poly(A) hnRNA with essentially no effect on smaller nuclear RNA species (< 5S).
D000818:Animals; D002478:Cells, Cultured; D004261:DNA Replication / Q000187:drug effects; D003609:Dactinomycin / Q000494:pharmacology; D004317:Doxorubicin / Q000031:analogs & derivatives* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000378:metabolism*; D051379:Mice; D012332:RNA, Heterogeneous Nuclear / Q000096:biosynthesis*
D012332:RNA, Heterogeneous Nuclear; D003609:Dactinomycin; C016163:valrubicin; D004317:Doxorubicin