Effect of extent of myocardial damage on the behavior of myocardial zinc in albino rats.
The effect of the extent of myocardial necrosis on myocardial zinc was studied in albino rats. Varying degrees of myocardial necrosis were produced by subcutaneous injection of two different doses of isoproterenol (85 mg/kg body wt and 42.5 mg/kg body wt). Myocardial necrosis was confirmed by serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), serum lactate dehydrogenase (SLDH), ECG, and histology. Myocardial zinc was depleted after the administration of isoproterenol. This depletion was proportional to the extent of myocardial damage. There was an attempt by the heart for re-uptake of zinc. However, this re-uptake could not be sustained in hearts with more extensive cardiac damage.
D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D006321:Heart / Q000187:drug effects; D007545:Isoproterenol / Q000494:pharmacology; D007770:L-Lactate Dehydrogenase / Q000097:blood; D009203:Myocardial Infarction / Q000378:metabolism*; D009206:Myocardium / Q000201:enzymology / Q000378:metabolism* / Q000473:pathology; D009336:Necrosis; D051381:Rats; D015032:Zinc / Q000378:metabolism*
D007770:L-Lactate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase; D015032:Zinc; D007545:Isoproterenol