Rheumatic fever and its sequels in children. A follow-up study with HLA analysis.
An analysis of 170 attacks (in 158 children) treated with a diagnosis of rheumatic fever (RF) in 1956-1961 or 1970-1974 showed that the Jones revised criteria of RF were fulfilled in about 1/2 of the attacks. Arthritis occurred in 72%, carditis in 39%, chorea in 18%, and erythema marginatum in 1% of the attacks with confirmed diagnosis. No chorea was observed in 1970-1974. Follow-up of the patients showed favorable prognosis and low frequency of recurrences of RF. HLA analysis showed frequencies of A and B loci were similar, whereas "blank" finding in locus C was rarer in RF patients than in controls.
D000293:Adolescent; D001168:Arthritis / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D006680:HLA Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D012008:Recurrence; D012213:Rheumatic Fever / Q000150:complications* / Q000453:epidemiology / Q000276:immunology; D012214:Rheumatic Heart Disease / Q000209:etiology; D013997:Time Factors
D006680:HLA Antigens