title: [Age dependence of the median duration of the mitotic cycle and the time for duplication of the hepatocyte number in ontogeny and in liver regeneration].
abstract: A mathematical intepretation is given for the published data on the kinetics of proliferation of the hepatocytes during ontogenesis and liver regeneration. The equations were obtained which described the age dependence of the mitotic cycle duration, the time of the cell number was found prior to the sexual maturation of the animals; the minimal and regeneration; a "break" of the curve describing the change of the time of duplication of the cell number was found prior to the sexual maturation of the animals; the minimal duration of the mitotic cycle and the time of duplication of the cell number during ontogenesis and liver regeneration was estimated; the age of animals was established at which the mitotic cycle of hepatocytes had the same duration as at the definite stage of liver regeneration.
mesh_terms: D000375:Aging; D000818:Animals; D002453:Cell Cycle; D002455:Cell Division; D007700:Kinetics; D008099:Liver / Q000166:cytology*; D008115:Liver Regeneration; D008433:Mathematics; D008938:Mitosis; D008954:Models, Biological; D051381:Rats; D013997:Time Factors
vernacular_title: O vozrastnoĭ zavisimosti sredneĭ prodolzhitel'nosti mitoticheskogo tsikla i vremeni udvoeniia chisla gepatotsitov v ontogeneze i pri regeneratsii pecheni.