The biotransformation and disposition of bronopol following topical and intravenous administration to rats.
Approx. 40% of the topically applied dose of antibacterial agent [14C] bronopol([14C]BP) was absorbed through the rat skin within 24 h. Of the applied radioactivity, about 19% was excreted in the urine, feces and expired air. The 24 h recoveries of 14C in the urine and expired air were 15 and 2%, respectively, of the dose applied to the skin, and 74 and 9%, respectively, of the dose given intravenously. The TLC of the urines showed three metabolites, but no unchanged [14C]BP in both groups. The results suggest that rat skin is quite permeable to bronopol.
D000287:Administration, Topical; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D001711:Biotransformation; D005260:Female; D007275:Injections, Intravenous; D010592:Pharmaceutic Aids / Q000378:metabolism*; D011310:Preservatives, Pharmaceutical / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D011409:Propylene Glycols / Q000008:administration & dosage / Q000378:metabolism* / Q000633:toxicity; D051381:Rats; D012869:Skin Absorption; D014018:Tissue Distribution
D000890:Anti-Infective Agents; D010592:Pharmaceutic Aids; D011310:Preservatives, Pharmaceutical; D011409:Propylene Glycols; C006827:bronopol