[Erythropoietin-independent stimulation of erythropoiesis in mice infected with Mycoplasma arthritidis].
It was found previously that M. arthritidis stimulates the endogenous colony formation in sublethally irradiated mice. It was of interest to solve the mechanism of the phenomenon. An attempt was made to show that M. arthritidis promotes the restoration of erythropoiesis in plethoric mice. It is a well known fact that in plethoric mice, the synthesis of endogenous erythropoietin is inhibited as well as the macroscopic erythroid colony formation. It is assumed that early initiation of erythropoiesis in mycoplasma-infected plethoric mice occurs because of either mycoplasma-induced restoration of erythropoietin synthesis or mycoplasma-directed involvement of the precursor cells in further differentiation and proliferation. Use was made of the method of 24-hour 59Fe uptake by the blood and spleen of plethorized mice and of other standard procedures aimed at revealing the erythropoietin activity in plasma of M. arthritidis-infected mice. Repeated attempts to recover the increased erythropoietin synthesis invariably failed. Hence the mycoplasma-induced erythropoiesis in plethorized mice is probably erythropoietin-independent and is consequent on the direct action of mycoplasma on the committed precursor cells.
D000818:Animals; D004920:Erythropoiesis; D004921:Erythropoietin / Q000096:biosynthesis; D006824:Hybridization, Genetic; D051379:Mice; D008805:Mice, Inbred A; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D009175:Mycoplasma Infections / Q000378:metabolism / Q000503:physiopathology*
D004921:Erythropoietin
Eritropoétinnezavisimaia stimuliatsiia éritropoéza u mysheĭ, infitsirovannykh Mycoplasma arthritidis.