title: Permeability into aortic intima and atherosclerotic plaque.
abstract: For the purpose of examining the interrelation between the permeability of the plasma constituents and the site of the atherosclerosis. We have perfused the solution of a dye into human aorta and observed permeability into aortic intima with aging and into atherosclerotic plaque. In addition, the deposition of bilirubin and fibrin into atherosclerotic plaque was also investigated. When the extent of the permeability was expressed as the ratio of the depth of permeability/thickness of intima, it was found that the ratio for the thoracic aorta decreased with advancing age. Permeability of the abdominal aorta occurred to show that the value of the ratio was up to 3.0 in the subject with age from 0 to 19 years and then the ratio slightly decreased with advancing age, followed by a further one step down in the seventies. Permeability into the atheromatous plaque showed diffuse pattern in the young adult but the permeability became shallower with advancing age. Regional difference of permeability around the plaque was studied. The greatest permeability was seen on the lower side of the plaque. Bilirubin and fibrin deposition into plaque was also similar to its permeability pattern.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D001011:Aorta / Q000503:physiopathology*; D001161:Arteriosclerosis / Q000209:etiology* / Q000473:pathology; D001663:Bilirubin; D002199:Capillary Permeability; D002648:Child; D002675:Child, Preschool; D005337:Fibrin; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged
chemical_list: D005337:Fibrin; D001663:Bilirubin