[Study results of the comprehensive influenza prevention with vaccines and remantadine during the influenza A(H1N1) outbreak in 1979].
During an outbreak of influenza in April, 1979, caused by A (H1N1) virus the protective effect of remantadine in combination with vaccinations using a national-made live A (H3N2) and inactivated A (H1N1) and B vaccines was studied. The best protective effect was achieved in the subjects vaccinated with influenza vaccines and given remantadine for urgent prophylaxis. Vaccination prophylaxis reduced the incidence of influenza and ARD 1.4-fold, prophylaxis with remantadine alone 2.3-fold.
D000218:Adamantane / Q000031:analogs & derivatives*; D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis; D004196:Disease Outbreaks / Q000517:prevention & control*; D004341:Drug Evaluation; D006801:Humans; D053118:Influenza A Virus, H1N1 Subtype; D009980:Influenza A virus / Q000276:immunology; D007252:Influenza Vaccines / Q000008:administration & dosage*; D007251:Influenza, Human / Q000517:prevention & control*; D010919:Placebos; D012299:Rimantadine / Q000627:therapeutic use*; D014611:Vaccination / Q000379:methods; D014613:Vaccines, Attenuated / Q000008:administration & dosage
D000914:Antibodies, Viral; D007252:Influenza Vaccines; D010919:Placebos; D014613:Vaccines, Attenuated; D012299:Rimantadine; D000218:Adamantane
Rezul'taty izucheniia kompleksnoĭ profilaktiki grippa vaktsinami i remantadinom vo vremia vspyshki grippa A(H1N1) v 1979 g.