title: Postovulatory decrease in estrogen production is caused by the diminished supply of aromatizable androgen to ovarian aromatase.
abstract: After administration of testosterone to immature rats which had ovulated after treatment with PMSG and hCG, a significant increase in ovarian content of estradiol-17 beta was observed. Together with our previous result on the immediate decrease in ovarian 17 alpha-hydroxylase and C-17-C-20 lyase after PMSG and hCG treatment, it is concluded that the drastic decrease in serum estradiol-17 beta after ovulation is caused by a shortage of supply of aromatizable androgen(s) to the ovarian aromatase, due to diminished activities of the above two enzymes.
mesh_terms: D000818:Animals; D001141:Aromatase / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D004958:Estradiol / Q000378:metabolism*; D005260:Female; D006064:Gonadotropins, Equine / Q000494:pharmacology; D010053:Ovary / Q000187:drug effects / Q000502:physiology*; D010060:Ovulation / Q000187:drug effects*; D010088:Oxidoreductases / Q000378:metabolism*; D051381:Rats; D012741:Sexual Maturation; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D006063:Chorionic Gonadotropin; D006064:Gonadotropins, Equine; D013739:Testosterone; D004958:Estradiol; D010088:Oxidoreductases; D001141:Aromatase