Decreased spiroperidol and LSD binding in rat brain after continuous amphetamine.
Rats were implanted with a silicone tubing pellet continuously releasing amphetamine base for several days. After five days of this treatment specific binding of spiroperidol (dopamine receptors) and LSD (serotonin receptors) was decreased in the corpus striatum and frontal cortex. In the striatum the number of dopamine receptors was decreased while the affinity was unchanged. These results indicate that dopamine and serotonin receptors can be regulated by the release of their own neurotransmitter.
D000661:Amphetamine / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002090:Butyrophenones / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism; D005625:Frontal Lobe / Q000378:metabolism; D066298:In Vitro Techniques; D008238:Lysergic Acid Diethylamide / Q000378:metabolism*; D008297:Male; D051381:Rats; D011954:Receptors, Dopamine / Q000378:metabolism; D011985:Receptors, Serotonin / Q000502:physiology; D013134:Spiperone / Q000378:metabolism*
D002090:Butyrophenones; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D013134:Spiperone; D008238:Lysergic Acid Diethylamide; D000661:Amphetamine