[Effect of nialamide administration on avoidance reactions in rats].
Enhanced level of dopamine in the brain caused by one-time administration of nialamide (125 mg/kg into the stomach) does not change the spontaneous motor activity, but increases the number of errors during elaboration of avoidance reaction and during its reversal (changing the side of reinforcement). The rise of the noradrenaline level in the brain, observed after 2 and 3 nialamide administrations does not change parameters of conditioning, but leads to an increase in spontaneous motor activity.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000502:physiology*; D002395:Catecholamines / Q000502:physiology*; D002421:Caudate Nucleus / Q000502:physiology; D004298:Dopamine / Q000502:physiology; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D009526:Nialamide / Q000494:pharmacology*; D009638:Norepinephrine / Q000502:physiology; D051381:Rats; D012193:Reversal Learning / Q000187:drug effects
D002395:Catecholamines; D009526:Nialamide; D004298:Dopamine; D009638:Norepinephrine
Vliianie vvedeniĭ nialamida na reaktsii izbeganiia u krys.