Effect of physiological concentrations of sex hormones on the formation of "early" sheep red blood cell rosettes by human lymphocytes. Possible relations with the presence of sex-hormone-cytosol-receptors in lymphocytes.
The formation of "early" sheep red blood cell rosettes by normal human peripheral blood lymphocytes was increased by incubation with physiological concentration of 17 beta-Estradiol. This effect was shown to be hormone specific. Whole cell incorporation of radioactive hormones and analysis by gel filtration of cytosols incubated with labeled hormones have shown a saturable fixation of estrogens and androgens. These results raise the possibility that normal human peripheral blood lymphocytes are target cells for sex steroid hormones.
D000818:Animals; D003600:Cytosol / Q000032:analysis; D004306:Dose-Response Relationship, Immunologic; D004958:Estradiol / Q000032:analysis / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000032:analysis / Q000276:immunology*; D008297:Male; D011960:Receptors, Estrogen / Q000032:analysis*; D012397:Rosette Formation; D012756:Sheep
D011960:Receptors, Estrogen; D004958:Estradiol