Antiandrogenic effect of cimetidine in mice.
Cimetidine (Tagamet) in the relatively high doses employed produced significant changes in seminal vesicles and kidney in mice. Cimetidine blocked the effect both of endogenous and of exogenous testosterone.
D000311:Adrenal Glands / Q000033:anatomy & histology / Q000187:drug effects; D000726:Androgen Antagonists; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002927:Cimetidine / Q000494:pharmacology*; D006146:Guanidines / Q000494:pharmacology*; D007668:Kidney / Q000033:anatomy & histology / Q000187:drug effects; D008297:Male; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D012669:Seminal Vesicles / Q000033:anatomy & histology* / Q000187:drug effects; D013739:Testosterone / Q000494:pharmacology
D000726:Androgen Antagonists; D006146:Guanidines; D013739:Testosterone; D002927:Cimetidine