[Administration of D-penicillamine instead of penicillin with fatal results: allergy of the delayed type with protracted shock as fatal complication of treatment with D-penicillamine for rheumatoid arthritis in a child (author's transl)].
Following one-week treatment with D-penicillamine for rheumatoid arthritis a seven-year-old girl died with the clinical features of protracted circulatory shock. Several doctors had mis-diagnosed the skin changes and mistakenly prescribed penicillamine, given for the rheumatoid arthritis, instead of plenicillin at the latter's dosage. By the administration of penicillamine a hypersensitivity reaction of the delayed type had been induced which ended fatally due to severe shock.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001344:Autopsy; D002648:Child; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006801:Humans; D008318:Malpractice; D010396:Penicillamine / Q000627:therapeutic use*; D012769:Shock / Q000209:etiology
D010396:Penicillamine
Folgenschwere Verwechslung von Penicillamin mit Penicillin. Allergie vom Spättyp mit protrahiertem Schock als tödliche Komplikation der Therapie mit D-Penicillamin bei rheumatoider Arthritis im Kindesalter.