Regional distribution of glutathione reductase in the adult rat brain.
Glutathione reductase was measured in 10 selected areas of the adult rat brain. Activitives varied over a 2.5-fold range. The caudate-putamen and cortical areas contained the highest activities. Several gray matter structures contained intermediate activities. The substantia nigra and the corpus callosum, a white matter structure, contained the lowest activities. The caudate-putamen, a catecholamine rich area, may produce H2O2 via MAO and would require glutathione reductase to recycle glutathione oxidized by glutathione peroxidase. However, the distribution of glutathione reductase activity also suggests a role in reducing oxidants formed during tissue respiration.
D000818:Animals; D001921:Brain / Q000201:enzymology*; D004298:Dopamine / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism; D051381:Rats; D014018:Tissue Distribution
D008995:Monoamine Oxidase; D005980:Glutathione Reductase; D004298:Dopamine