The inheritance pattern of factor XII (Hageman) deficiency in domestic cats.
Measurements of coagulation factor XII levels in F1 progeny of a cat having factor XII deficiency revealed an autosomal recessive pattern similar to that reported in humans (Hageman trait). A study of the pedigree of the colony revealed that F1 kittens had approximately 50% factor XII activity while kittens produced by backcrossing with an F1 progeny possessed an average of 50% and a less than 2% factor XII activity in an approximate 1:1 ratio. Kittens having an average of 50% factor XII activity were postulated heterozygous for the trait while progeny with less than 2% activity were considered genetically homozygous.
D000818:Animals; D002371:Cat Diseases / Q000235:genetics*; D002415:Cats; D003433:Crosses, Genetic; D005174:Factor XII / Q000032:analysis; D005175:Factor XII Deficiency / Q000235:genetics / Q000662:veterinary*; D005260:Female; D005808:Genes, Recessive; D008297:Male; D010375:Pedigree
D005174:Factor XII