title: Upper and lower airway hyperreactivity in recurrent croup.
abstract: Seventeen children with recurrent croup, who had their last episode within the previous 12 months, were evaluated clinically by allergy skin tests, pulmonary function tests, and a histamine inhalation challengae. Fourteen showed airway hyperreactivity. Flow-volume loops were obtained after a positive histamine response and compared with post histamine tracings of children with asthma and health control subjects. Children with recurrent croup as well as those with asthma showed a significantly greater fall in maximal expiratory flow rates than that shown in healthy control subjects. Those recurrent croup also had a significantly greater fall in maximal inspiratory flow rates when compared to those with asthma and to the control subjects. A specific type airway hyperreactivity suggestive of involvement of both upper and lower respiratory tract was seen in children with recurrent croup.
mesh_terms: D000293:Adolescent; D001249:Asthma / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D002648:Child; D003440:Croup / Q000503:physiopathology*; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D007827:Laryngitis / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D012008:Recurrence; D012119:Respiration / Q000187:drug effects*; D012129:Respiratory Function Tests; D013997:Time Factors; D014797:Vital Capacity
chemical_list: D006632:Histamine