title: Binary developmental commitments in normal and abnormal human morphogenesis.
abstract: An hypothesis is presented to account for the occurrence of overlapping patterns of anomalies in various malformation syndromes. According to this proposal, normal human morphogenesis occurs by means of a series of sequential commitments by neighboring groups of cells to alternative developmental programs.
mesh_terms: D000015:Abnormalities, Multiple / Q000196:embryology / Q000209:etiology*; D000013:Congenital Abnormalities / Q000196:embryology*; D005260:Female; D006801:Humans; D009024:Morphogenesis; D011247:Pregnancy