title: [Activity of small intestine alkaline phosphatase in the feces in chronic intestinal diseases].
abstract: In comparison to normal controls (n = 71) the activity of intestinal alkaline phosphatase in feces is reduced in chronic bowel disease using an immunoprecipitation method: patients with Crohns disease (n = 40) or inactive ulcerative colitis (n = 29) demonstrate small changes of fecal intestinal alkaline phosphate activity in comparison to normal controls. Intestinal alkaline phosphatase is reduced in patients with active ulcerative colitis (n = 11) to 50%, in patients with uraemic enteropathy (n = 18) to 30% and in patients with coeliac disease (n = 14) to 20% of the activity observed in normal controls. During cytostatic treatment of malignant tumors, fecal intestinal alkaline phosphatase activity increases as a sign of toxic damage of the intestinal mucosa.
mesh_terms: D000469:Alkaline Phosphatase / Q000378:metabolism*; D002908:Chronic Disease; D003093:Colitis, Ulcerative / Q000201:enzymology; D003424:Crohn Disease / Q000201:enzymology; D005243:Feces / Q000201:enzymology*; D006801:Humans; D007410:Intestinal Diseases / Q000201:enzymology*; D007413:Intestinal Mucosa / Q000201:enzymology; D007421:Intestine, Small / Q000201:enzymology*
chemical_list: D000469:Alkaline Phosphatase
vernacular_title: Die Aktivität der alkalischen Dünndarmphosphatase im Stuhl bei chronischen Darmerkrankungen.