Aneuploidy in culture.
On one hundred consecutive clinically referred patients, a total of 3,175 cells was fully analysed. The parameters of culture and analysis were the same for all patients, and a breakdown of cells showed 258 cells (8.1 per cent) with hypomodal counts and sixty-two cells (1.9 per cent) with hypermodal counts. The great majority of the hypomodal cells contained forty-five chromosomes and the distribution of chromosome loss from these cells was non-random, with fewer than expected of the large chromosomes (groups A, B and C) being lost, and more than expected of the small chromosomes (group E and G) being lost. The distribution of the chromosomes gained in the hypermodal cells was random (except for the C group where the numbers were small). In this data, there was no significant difference of aneuploidy in culture noted for sex, age, or patient referral group.
D000293:Adolescent; D000328:Adult; D000782:Aneuploidy; D002648:Child; D002675:Child, Preschool; D002869:Chromosome Aberrations / Q000235:genetics; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008607:Intellectual Disability / Q000235:genetics; D008297:Male; D008875:Middle Aged