Carbamazepine-10,11-epoxide determined by EMIT carbamazepine reagent.
Carbamazepine-10,11-epoxide (CBZ-OX) was determined in physiological solutions by means of EMIT carbamazepine reagent. It was recognized as 12 to 20% of the total amount, the cross-reaction being higher at lower CBZ-OX concentrations. A correction for CBZ-OX is necessary when one wants to correlate EMIT carbamazepine values with gas-liquid chromatography values. However, this correction is relevant only for body fluids other than plasma, since the unbound fraction of CBZ-OX would greatly influence the ultrafiltrate serum ratios.
D001711:Biotransformation; D002220:Carbamazepine / Q000378:metabolism*; D003201:Computers; D006801:Humans; D007118:Immunoassay
D002220:Carbamazepine