[Changes in succinate dehydrogenase activity in the cerebral cortex as an effect of aminazin (histochemical and electron-cytochemical study)].
The activity and localization of succinate dehydrogenase (SDH) in the cortex of rats was studied before and after aminazin administration (15 mg/kg). Changes in the enzyme activity according to photometry occurred in 2 directions: a general drop in the activity of neurons and neuropile, a decrease in the amount of neurons reacting to SDH. Ultrastructurally the enzyme was detectable in the mitochondria of the cell body, adjacent processes and in the processes of cells circumscribing the vessels. In most of the neuropile mitochondria the product of the reaction was not found. Under the influence of aminazin there appeared dark neurons not containing organellas with products of reaction. There were also light neurons in the mitochondria without products of reaction and lipofucsin granules containing products of reaction. The above-mentioned changes permit to explain the drop in the SDH activity, found on photometry of histochemical changes.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000201:enzymology / Q000648:ultrastructure; D002746:Chlorpromazine / Q000494:pharmacology*; D003864:Depression, Chemical; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000201:enzymology; D051381:Rats; D011919:Rats, Inbred Strains; D013385:Succinate Dehydrogenase / Q000378:metabolism*
D013385:Succinate Dehydrogenase; D002746:Chlorpromazine
Izmeneniia aktivnosti suktsinatdegidrogenazy v kore golovnogo mozga pod vliianiem aminazina (gistokhimicheskoe i élektronno-tsitokhimicheskoe issledovanie).