Dicloxacillin and flucloxacillin twice daily with probenecid in staphylococcal infections. A clinical and pharmakokinetic evaluation.
The therapeutic efficacy of decloxacillin or flucloxacillin, 1--2 g orally with probenecid twice daily was evaluated in staphylococcal infections. Excellent results were obtained with this as long-term maintenance therapy in 4 patients with relapsing chronic osteomyelitis and in 6 patients with postoperative infections. No side effects were observed in these patients. In 35 patients with furunculosis twice daily administration of dicloxacillin was used as a primary therapeutic regimen. All healed, but 4 recurrencies occurred during a 3-month observation period after therapy. In 5 patients allergic reactions were noted. The unbound fraction of flucloxallin in serum exceeded MIC values of methicillin-susceptible Staphylococcus aureus during 11 of 24 h. Pharmacokinetic data on flucloxallin with and without probenecid are given.
D003023:Cloxacillin / Q000031:analogs & derivatives*; D004009:Dicloxacillin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D004338:Drug Combinations; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005436:Floxacillin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D005667:Furunculosis / Q000188:drug therapy; D006801:Humans; D010019:Osteomyelitis / Q000188:drug therapy; D011339:Probenecid / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D012008:Recurrence; D013203:Staphylococcal Infections / Q000188:drug therapy*; D013211:Staphylococcus aureus / Q000187:drug effects; D013530:Surgical Wound Infection / Q000188:drug therapy
D004338:Drug Combinations; D005436:Floxacillin; D004009:Dicloxacillin; D003023:Cloxacillin; D011339:Probenecid