title: Repeated investigations of cyclophosphamide disposition in myeloma patients receiving intermittent chemotherapy.
abstract: 1 The disposition of cyclophosphamide was investigated in a group of myeloma patients. 2 Marked changes in clearance and volume of distribution of cyclophosphamide occurred between investigations. 3 The observed changes in disposition did not correlate with biochemical estimates of renal and hepatic function or plasma protein status.
mesh_terms: D000328:Adult; D000368:Aged; D000478:Alkylation; D003520:Cyclophosphamide / Q000378:metabolism*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007668:Kidney / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000378:metabolism*
chemical_list: D003520:Cyclophosphamide