Binary developmental commitments in normal and abnormal human morphogenesis.
An hypothesis is presented to account for the occurrence of overlapping patterns of anomalies in various malformation syndromes. According to this proposal, normal human morphogenesis occurs by means of a series of sequential commitments by neighboring groups of cells to alternative developmental programs.
D000015:Abnormalities, Multiple / Q000196:embryology / Q000209:etiology*; D000013:Congenital Abnormalities / Q000196:embryology*; D005260:Female; D006801:Humans; D009024:Morphogenesis; D011247:Pregnancy