Influence of cadmium and copper on the distribution pattern of plutonium in the rat.
The results of pilot experiments on metal interactions in vivo are presented. In rats pretreated with a single injection of Cd, substantially less Pu accumulated in the liver, while significantly more was found after pretreatment with Cu. In bone, somewhat more Pu was detected after Cd and less after Cu administration. Both metals increased the retention of Pu in the kidneys and spleen. The changes were similar with 238Pu and 239Pu and were still present 1 wk after Pu administration; in the case of Cu they were dependent on the amount administered. All the changes described concern solely the tissue distribution pattern of Pu; the total amount of Pu retained in the organs studied remained the same. The possible relation of Pu uptake to induced synthesis of Cd-thionein and Cu-chelatin is discussed.
D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D003300:Copper / Q000494:pharmacology*; D005260:Female; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008668:Metallothionein / Q000378:metabolism; D011005:Plutonium / Q000378:metabolism*; D051381:Rats; D013154:Spleen / Q000187:drug effects
D002104:Cadmium; D011005:Plutonium; D003300:Copper; D008668:Metallothionein