title: [Functional activity of the macrophage elements of animal peritoneal exudate in the process of infection by tick-borne encephalitis complex viruses].
abstract: Investigations of the functional activity values of macrophages showed that free peritoneal macrophages of random-bred mice and guinea pigs participated in primary immune response to a single subcutaneous inoculation of the Pan strain of tick-borne encephalitiss virus. TR-21 strain of Langat virus, and the 237 strain, an experimentally attenuated variant of the latter. When the mice developed an acute infection, functional changes of macrophages were characterized by increased phagocytic activity towards infected cells. In subacute infection in mice and inapparent infection in guinea pigs nonspecific resistance increased as manifested in activation of phagocytosis of non-infected cells and developing in the presence of immune response and specific sensitization of the animal hosts.
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001202:Ascitic Fluid / Q000276:immunology*; D002448:Cell Adhesion; D004675:Encephalitis, Tick-Borne / Q000209:etiology / Q000276:immunology*; D006168:Guinea Pigs; D007111:Immunity, Cellular; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D010587:Phagocytosis; D013997:Time Factors
chemical_list: D000914:Antibodies, Viral
vernacular_title: Izuchenie funktsional'noĭ aktivnosti makrofagal'nykh élementov peritoneal'nogo ékssudata zhivotnykh v protsesse infitstirovaniia virusami kompleksa kleshchevogo éntsefalita.