Mechanisms of immune lysis. II. CTL-induced nuclear disintegration of the target begins within minutes of cell contact.
Within minutes of CTL-target interaction, the intracellular disintegration of the target cell nucleus begins. This nuclear event satisfies the ionic and temperature requirements that have been described by others as important in CTL-mediated lysis. Such nuclear disintegration does not occur in Ab+C-lysed targets. Thus the target cell nucleus appears to signal a primary event in CTL-mediated lysis that distinguishes the CTL lytic mechanism from that of Ab+C.
D000818:Animals; D000906:Antibodies; D002118:Calcium / Q000378:metabolism; D002450:Cell Communication; D002467:Cell Nucleus / Q000276:immunology*; D003165:Complement System Proteins; D003602:Cytotoxicity, Immunologic; D008274:Magnesium / Q000378:metabolism; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D011092:Polyethylene Glycols / Q000494:pharmacology; D011817:Rabbits; D012995:Solubility; D013997:Time Factors; D014529:Uridine / Q000378:metabolism
D000906:Antibodies; D011092:Polyethylene Glycols; D003165:Complement System Proteins; D008274:Magnesium; D002118:Calcium; D014529:Uridine