Methyl red azo-reductase and its induction by 3-methylcholanthrene in the liver by different species.
1. Methyl red azo-reductase activity in the liver cytosol of mouse and sheep was considerably less than in the rat, guinea-pig, rabbit and hamster. In the mouse, the total activity of this soluble enzyme to reduce methyl red was only 4% of that found in rat. 2. Species variation in methyl red azo-reductase of microsomes was relatively small compared to that of the cytosol. 3. Azo-reductase in the cytosol of mouse liver also differed from that of the rat in its resistance to the inductive effects of 3-methylcholanthrene.
D000818:Animals; D001391:Azo Compounds / Q000378:metabolism; D006224:Cricetinae; D003600:Cytosol / Q000201:enzymology; D006168:Guinea Pigs; D008099:Liver / Q000201:enzymology*; D008297:Male; D008748:Methylcholanthrene / Q000378:metabolism*; D051379:Mice; D008862:Microsomes, Liver / Q000201:enzymology; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity
D001391:Azo Compounds; D008748:Methylcholanthrene; D009247:NADH, NADPH Oxidoreductases; C021584:methyl red azoreductase