Site of bronchospasm in exercise-induced asthma.
Bronchoconstriction induced by a bicycle ergometer reached a maximum at the 3rd and 6th minutes after exercise. The values of maximal expiratory flow measured at 25, 50 and 75% of forced vital capacity, peak expiratory flow and specific airways conductance, in cases of exercise-induced asthma, indicated that the obstruction of the large airways precedes and, in intensity, surpasses that of the small ones. Bronchial lability index was used for the comparison of the changes in the different parameters. Bronchoconstriction provoked by exercise is considered as a suitable model for the general study of the pathophysiology of bronchial asthma.
D000328:Adult; D000403:Airway Resistance; D001249:Asthma / Q000503:physiopathology*; D001250:Asthma, Exercise-Induced / Q000503:physiopathology*; D001980:Bronchi / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008448:Maximal Expiratory Flow Rate; D005082:Physical Exertion; D013997:Time Factors; D014797:Vital Capacity