Monitoring of microthrombosis in experimental animals by continuous recording of 125I-fibrin deposits and 51Cr-labelled platelets in the lungs.
A method for continuous monitoring of microthrombosis in the lungs is described. After injection of labelled fibrinogen and platelets the accumulation of these blood constituents was estimated during experimental disseminated intravascular coagulation (DIC) by radioactivity measurement on the body surface. By optimizing the measuring geometry of a single hole collimator for scintillation probes a high relative efficiency was attained and a defined area of the lung was viewed. This method allows recording of the trapping of fibrin and platelets in the lungs in experimental DIC and investigations on the pharmacological control of this condition.
D000818:Animals; D001777:Blood Coagulation; D001792:Blood Platelets; D002860:Chromium Radioisotopes; D004195:Disease Models, Animal; D005260:Female; D005337:Fibrin; D007457:Iodine Radioisotopes; D008991:Monitoring, Physiologic / Q000379:methods*; D010976:Platelet Count; D011652:Pulmonary Circulation; D011655:Pulmonary Embolism / Q000175:diagnosis*; D051381:Rats; D012588:Scintillation Counting
D002860:Chromium Radioisotopes; D007457:Iodine Radioisotopes; D005337:Fibrin