title: [Pharmacological activity of the optical isomers of sydnocarb].
abstract: Of the two optical isomers of sydnocarb, only 1- (or 1R)-isomer exerts a stimulant effect on the central nervous system. By its stimulant action it differs from both optical isomers of amphetamine. The activity of 1-(IR)-sydnocarb as measured by the locomotor excitation test is similar to that of d(1S)-amphetamine but is significantly less powerful as indicated by stereotypy, hyperthermia, anorexigenic action and antagonism to the depressant effects of reserpine.
mesh_terms: D000661:Amphetamine / Q000494:pharmacology / Q000633:toxicity; D000818:Animals; D001067:Appetite Depressants; D001831:Body Temperature / Q000187:drug effects; D002490:Central Nervous System / Q000187:drug effects; D007536:Isomerism; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D010069:Oxadiazoles / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology* / Q000633:toxicity; D051381:Rats; D013558:Sydnones / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D001067:Appetite Depressants; D010069:Oxadiazoles; D011619:Psychotropic Drugs; D013558:Sydnones; D000661:Amphetamine; C009257:sidnocarb
vernacular_title: Farmakologicheskaia aktivnost' opticheskikh izomerov sidnokarba.