Effect of indomethacin on monoamine metabolism and melatonin synthesis in rat pineal gland.
Indomethacin treatment of rats resulted in a significant increase of pineal monoamine oxidase (MAO) type A activity, whereas it depressed MAO type B and hydroxyindole-O-methyl transferase activities. Indomethacin also significantly impaired the nocturnal rise of pineal serotonin-N-acetyltransferase activity and melatonin content. These results suggest a role for prostaglandins in the regulation of pineal function.
D000121:Acetylserotonin O-Methyltransferase / Q000378:metabolism; D000818:Animals; D001679:Biogenic Amines / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D008550:Melatonin / Q000096:biosynthesis*; D008995:Monoamine Oxidase / Q000378:metabolism; D010870:Pineal Gland / Q000187:drug effects*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats
D001679:Biogenic Amines; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D008995:Monoamine Oxidase; D000121:Acetylserotonin O-Methyltransferase; D008550:Melatonin; D007213:Indomethacin