ADCC effector function in patients with atopic dermatitis. A possible mechanism of susceptibility to severe cutaneous viral infections.
Peripheral blood mononuclear cells from patients with chronic atopic dermatitis were evaluated as effectors of antibody-dependent cellular cytotoxicity (ADCC) to determine if faulty effector function might explain the susceptibility of atopics to severe cutaneous viral infections in spite of adequate specific antibody titers. Eleven atopic patients whose dermatitis was well controlled and who were not infected or on immunosuppressive therapy were studied using sensitized human and chicken erythrocyte targets at three different effector:target ratios. No significant differences in mean ADCC were seen between atopics and controls. However, the function of peripheral blood mononuclear cells from atopic patients who had a previous history of severe cutaneous viral infection was significantly depressed against sensitized chicken, but not human targets. This suggests that atopic patients who develop severe cutaneous viral infections may represent a subset of atopics with an intrinsic or variable defect in K lymphocyte--mediated ADCC which might render them susceptible to persistent, extensive viral infections.
D000328:Adult; D000818:Animals; D000920:Antibody-Dependent Cell Cytotoxicity; D002645:Chickens; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology*; D004198:Disease Susceptibility / Q000276:immunology; D006801:Humans; D008214:Lymphocytes / Q000276:immunology; D009000:Monocytes / Q000276:immunology; D012874:Skin Diseases, Infectious / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*