[Edemas and myocloni concerning a patient with Parkinson's disease treated by amantadine (author's transl)].
The administration of diuretics to a 64 year old patient with Parkinsonian disease treated by amantadine, orphenadrine and Modopart and presenting an oedemia of the legs, induced the apparition of myoclonic jerks similar to those observed in a bismuth intoxication. The myoclonic jerks remained after the diuretics were stopped and only disappeared with the suppression of amantadine. It is supposed that diuretics increased the intoxication by amantadine, probably by means of an increase of the reabsorption of basic drugs. Myoclonius may be caused by the central anticholinergic properties of amantadine.
D000547:Amantadine / Q000009:adverse effects* / Q000627:therapeutic use; D004232:Diuretics / Q000009:adverse effects; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D004487:Edema / Q000139:chemically induced*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009207:Myoclonus / Q000139:chemically induced*; D010302:Parkinson Disease, Secondary / Q000188:drug therapy*
D004232:Diuretics; D000547:Amantadine
Edème et myoclonies chez un parkinsonien traité par Mantadix. Problème des associations médicamenteuses.