title: Reactivity pattern of vasopressin-containing neurons and its relation to the antipyretic reaction in the pregnant guinea pig.
abstract: Changes in the content of vasopressin-immunoreactive material in neurons and their projections were examined in pregnant and nonpregnant guinea pigs as well as in mother and newborn animals. Before sacrifice all animals used in the present study were submitted to a pyrogen test, during which the pregnant animals displayed a reduced fever response to exogenous pyrogen. The unlabeled enzyme-immunoperoxidase method was used in the present study. Light microscopic examination showed that, in comparison to all other groups examined, the pregnant animals exhibited a reduced content of the vasopressin-immunoreactive substance in the supraoptic nucleus (SON), in the neuronal pathways extending between the paraventricular nucleus (PVN) and the SON, as well as in the axons projecting to the neural lobe of the pituitary. An increased amount of vasopressin-immunoreactive material was observed during pregnancy especially in the medial portion of the PVN, in axonal distensions in the external zone of the median eminence and in the extrahypothalamic projection sites of the PVN in the lateral septum and in the amygdala. In the pregnant animals neurovascular contacts of vasopressinergic perikarya and fibers were abundant in the PVN; in the lateral septum and in the amygdala vasopressinergic terminals appeared to contact neurons of other types. It is suggested from the present immunocytochemical results that activation of neurons in the medial portion of the PVN and the increased number of vasopressinergic terminals and preterminals in the lateral septum and in the amygdala might be functionally involved in fever suppression at the term of pregnancy.
mesh_terms: D000679:Amygdala / Q000032:analysis; D000818:Animals; D000831:Animals, Newborn; D001127:Arginine Vasopressin / Q000032:analysis / Q000502:physiology*; D001369:Axons / Q000032:analysis; D005260:Female; D005334:Fever / Q000503:physiopathology*; D006168:Guinea Pigs; D007031:Hypothalamus / Q000032:analysis; D009434:Neural Pathways / Q000032:analysis; D010286:Paraventricular Hypothalamic Nucleus / Q000032:analysis; D010904:Pituitary Gland, Posterior / Q000294:innervation; D011247:Pregnancy; D011270:Pregnancy, Animal; D013495:Supraoptic Nucleus / Q000032:analysis
chemical_list: D001127:Arginine Vasopressin