title: Hyperaminoaciduria in mild phosphate diabetes in adults.
abstract: Quantitative  urinary amino acid excretion has been studied in 23 adult patients with mild phosphate diabetes (MPD), in 22 adult control patients with various renal disorders and in 15 children, 7--19 years old, with atopic disorders (normal controls). Statistically significant increases in urinary excretion of glutamine (p < 0.01), glycine (p < 0.01) and cystine (p < 0.05) were found in the MPD patients compared to the normal controls. The urinary excretion of glutamine was significantly increased while the increases in cystine and glycine excretions were non-significant when MPD patients were compared to the control patients. In addition to clinical signs and analyses of plasma and urinary phosphate, a quantitative evaluation of urinary amino acids might be a tool in the diagnosis of MPD. The significance of the increased urinary amino acid excretion in MPD is discussed.
mesh_terms: D000328:Adult; D003553:Cystine; D003555:Cystinuria; D005260:Female; D005973:Glutamine / Q000652:urine; D005998:Glycine / Q000652:urine; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000150:complications / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000652:urine*; D000608:Renal Aminoacidurias / Q000150:complications*
chemical_list: D010710:Phosphates; D005973:Glutamine; D003553:Cystine; D005998:Glycine