A comparative study of the gastric ulcerogenic effects of stress and reserpine in rats with decreased stomach wall mast cell populations.
Stress-induced gastric glandular ulcers in rats appeared less severe than those evoked by reserpine, although glandular mucosal mast cell counts were equally decreased. Prior depletion of the glandular mucosal mast cell population confirmed the hypothesis that an additional mechanism contributes to reserpine ulceration.
D000818:Animals; D002452:Cell Count; D003907:Dexamethasone / Q000494:pharmacology; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology*; D008407:Mast Cells / Q000502:physiology*; D051381:Rats; D012110:Reserpine / Q000633:toxicity*; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology*; D013312:Stress, Physiological / Q000150:complications*
D003907:Dexamethasone; D012110:Reserpine