Acetylcholinesterase activity in rat brain: effect of acute cyanide intoxication.
Acetylcholinesterase (AChE) activity in the cerebral cortex, cerebellum, hippocampus, hypothalamus, midbrain, pons and medulla oblongata of mature male rats was determined in control and cyanide-treated animals by a spectrophotometric method. Compared with control, cyanide-treated animals showed significant increases in the AChE activity of the cerrebral cortex, hippocampus and midbrain. This finding suggests an involvement of brain AChE in acute cyanide toxicity.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002531:Cerebellum / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D003486:Cyanides / Q000506:poisoning*; D006624:Hippocampus / Q000201:enzymology; D007031:Hypothalamus / Q000201:enzymology; D008297:Male; D008526:Medulla Oblongata / Q000201:enzymology; D008636:Mesencephalon / Q000201:enzymology; D011149:Pons / Q000201:enzymology; D051381:Rats; D012966:Sodium Cyanide / Q000506:poisoning*
D003486:Cyanides; D000110:Acetylcholinesterase; D012966:Sodium Cyanide