title: Early metabolic changes following destruction of the ventromedial hypothalamic nuclei.
abstract: Studies were performed to determine whether increased gluconeogenesis precedes or is necessary for increased lipogenesis after ventromedial hypothalamic destruction. Weanling male rats were injected with 14C-bicarbonate or with 3H2O to assess gluconeogenesis or lipogenesis, respectively, at various short time intervals after placement of hypothalamic lesions. Lipogenesis increased within 2 hr of lesion placement whereas gluconeogenesis did not change for at least 4 hr. The results indicate that lipogenesis increases before gluconeogenesis and, therefore, that enhanced glucose production is not necessary for increased lipogenesis to occur in these rats.
mesh_terms: D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D001786:Blood Glucose / Q000378:metabolism; D005943:Gluconeogenesis; D007031:Hypothalamus / Q000502:physiology*; D007033:Hypothalamus, Middle / Q000378:metabolism / Q000502:physiology*; D008055:Lipids / Q000096:biosynthesis*; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D051381:Rats; D014867:Water / Q000378:metabolism
chemical_list: D001639:Bicarbonates; D001786:Blood Glucose; D008055:Lipids; D008112:Liver Glycogen; D014867:Water