Ozone induced alterations in phenol red absorption from the rat lung.
The  effect of inhaled ozone (O3) on the integrity of lung transport processes for phenol red has been determined. Phenol red (1, 10, or 100 mumol) was applied intratracheally to rat lungs in vivo and in an isolated lung preparation. In both test systems the rates of removal were found to be similar and to compare favorably with reported values. Animals exposed to O3 for 24 h demonstrated loss of carrier-mediated transport for this ion. The effect was also found to be related to the concentration of O3. These results indicate that the carrier-mediated component of phenol red removal from the airways of the lung may be used as a marker for pulmonary membrane damage resulting from the inhalation of atmospheric toxicants.
D000042:Absorption; D000818:Animals; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D010126:Ozone / Q000494:pharmacology*; D010635:Phenolphthaleins; D010637:Phenolsulfonphthalein; D051381:Rats
D010635:Phenolphthaleins; D010126:Ozone; D010637:Phenolsulfonphthalein