n-Octane and n-nonane induced alterations in xenobiotic metabolising enzyme activities and lipid peroxidation of rat liver.
After 2 and 7 days on n-octane and n-nonane administration (intraperitoneally) to female albino rats, alterations in the levels of hepatic xenobiotic metabolising enzyme activities and TBA reactants were observed. Fifty to eighty per cent reduction in the specific activities of benzo[a]pyrene hydroxylase, benzphetamine-N-demethylase, p-nitroanisole-O-demethylase and glutathione-S-transferase were observed. Cytochrome P-450 and free sulfhydryl contents of liver were also decreased significantly after 7 days treatment on n-octane and n-nonane. A 2- and 3- fold increase in liver lipid peroxidation estimated as TBA reactants was observed in the animals treated for 2 or 7 days with n-octane or n-nonane.
D000473:Alkanes / Q000633:toxicity*; D000818:Animals; D065607:Cytochrome P-450 Enzyme Inhibitors; D005260:Female; D008054:Lipid Peroxides / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D009795:Octanes / Q000633:toxicity*; D051381:Rats
D000473:Alkanes; D065607:Cytochrome P-450 Enzyme Inhibitors; D008054:Lipid Peroxides; D009795:Octanes; C017573:nonane; C026728:octane