Experimental myocarditis. I. Cardiac lesions in rats induced by immunization with homologous heart extracts.
The production of myocardial lesions and circulating anti-heart antibodies has been studied in rats injected with homologous heart extracts emulsified with the Freund's complete adjuvant and the DTP vaccine. Six of 7 rats showed lesions of focal myocarditis, while only in one of them circulating anti-heart antibodies were detected. There was no correlation between the presence of circulating anti-heart antibodies and that of myocardial lesions. These findings suggested that the circulating anti-heart antibodies may play little or no role in the pathogenesis of this experimental myocarditis.
D000818:Animals; D000906:Antibodies / Q000032:analysis; D007114:Immunization; D009205:Myocarditis / Q000209:etiology / Q000276:immunology / Q000473:pathology*; D009206:Myocardium / Q000276:immunology* / Q000473:pathology; D051381:Rats; D014020:Tissue Extracts / Q000276:immunology
D000906:Antibodies; D014020:Tissue Extracts