title: Effects of high-protein, low-carbohydrate dieting on plasma lipoproteins and body weight.
abstract: Twenty-four obese but otherwise normal men and women were followed for: Two weeks on their usual food intake; eight weeks on a high-protein, low-carbohydrate diet; and then again for two weeks on their usual diet. During this time, several metabolic parameters were measured bimonthly. The high-protein, low-carbohydrate dieting resulted in substantial weight loss, probably due to a combination of salt and water loss, as well as caloric restriction. Plasma triglycerides fell as well. Significant increases occurred in LDL-cholesterol, uric acid, and free fatty acid levels. HDL-cholesterol levels failed to rise despite significant weight loss, indicating that the previously reported relationship between HDL-cholesterol and weight may be dependent, in part, on the composition of the diet.
mesh_terms: D000328:Adult; D001835:Body Weight; D002784:Cholesterol / Q000097:blood; D004033:Diet Fads; D004038:Diet, Reducing / Q000592:standards*; D004040:Dietary Carbohydrates / Q000494:pharmacology*; D004044:Dietary Proteins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D012737:Sex Factors
chemical_list: D004040:Dietary Carbohydrates; D004044:Dietary Proteins; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D002784:Cholesterol