[Reaction of the heart of chemically desympathized animals to functional loading].
Effect of chemical desympathization on heart contractile function was studied in experiments on Wistar rats (22 experimental and 20 control animals) under conditions of exposure to functional loads. These loads were realized by heart stimulation at an increasing rate and by a short-term aorta occlusion (as maximum load). The data obtained indicate the depression of contractile function of the desympathized heart exposed to stimulation and maintenance of its contractility under occlusion. It is inferred that the adaptation resources of the desympathized heart are reduced under conditions that require mobilization of the mechanism [interval -- force] and are preserved during heart hyperfunction in isometric regime.
D000818:Animals; D001794:Blood Pressure; D006145:Guanethidine / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009200:Myocardial Contraction; D051381:Rats; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*
D006145:Guanethidine
Reaktsiia serdtsa khimicheski desimpatizirovannogo zhivotnogo na funktsional'nye nagruzki.