Electron microscopic study of the early changes proximal to a constriction in myelinated nerve.
An ultrastructural study has been carried out of the changes observed proximal to a nerve constriction in rabbits. The lesion was experimentally produced with a silk ligature. Specimens were examined 24 h after ligation. Significant alterations of the ultra structure were found in sections taken at approximately 1 mm above the constriction. Examination revealed swelling of the nerve fibres due to failure of axoplasmic flow, a marked increase in the number of mitochondria, most of which showed degenerative changes and degenerative changes in the myelin sheath.
D000818:Animals; D008026:Ligation; D008928:Mitochondria / Q000648:ultrastructure; D009186:Myelin Sheath / Q000648:ultrastructure; D009408:Nerve Compression Syndromes / Q000473:pathology; D009410:Nerve Degeneration; D009413:Nerve Fibers, Myelinated / Q000648:ultrastructure*; D011817:Rabbits; D012583:Schwann Cells / Q000648:ultrastructure; D013979:Tibial Nerve / Q000648:ultrastructure*