Altered haemorheology in oral-contraceptive users.
The haemorheological profile of the menstrual cycle was determined in 12 women who did not take oral contraceptives and compared with that in two groups of women (n = 8 and n = 30) who had been taking oral contraceptives for at last six months. Packed cell volume, platelet count, erythrocyte deformability, plasma fibrinogen concentration, and plasma and whole-blood viscosity varied cyclically throughout the menstrual cycle in the 12 non-users. This variation was abolished by the use of oral contraceptives, and the values of these indices were raised by an amount likely to predispose to thrombosis.
D000328:Adult; D001769:Blood / Q000187:drug effects; D001790:Blood Physiological Phenomena; D001809:Blood Viscosity / Q000187:drug effects; D003276:Contraceptives, Oral / Q000009:adverse effects*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects*; D004909:Erythrocyte Indices / Q000187:drug effects; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D006400:Hematocrit; D006801:Humans; D008598:Menstruation; D010976:Platelet Count; D012212:Rheology
D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D005340:Fibrinogen