The pharmacologic treatment of newborn diaphragmatic hernia--a 2-year evaluation.
From 1968 to 1976 inclusive, 69 neonates with diaphragmatic hernias had corrective surgery within 18 hr of birth and the survival rate was 41%. During the same time, all babies with similar hernias who were operated on later than 18 hr from the time of birth survived. Our present interest has been focused on the pulmonary artery and its hypertension with the subsequent development of right to left shunting through the patent ductus arteriosus. During 1977 and 1978, we attempted to enter 19 consecutive newborns 18 hr of age or less with symptomatic Bochdalek diaphragmatic hernias into a "Collins protocol" for treatment. This included four stages: newborn nursery initial resuscitation, operation, cardiac catheterization, and ICU monitoring and pharmacological therapy. There was a total of seven survivors (36%), however for a number of reasons only eight babies really had a complete entry into this protocol and of these eight, five survived. Although this study is far from complete, some initial information and concepts are forthcoming. It is now apparent to us that there are three distinct groups into which these very early newborns fall: minimal pulmonary hypoplasia, unilateral hypoplasia and bilateral hypoplasia. The first group probably does not need pharmacologic support, while in the last it probably does not help. Further interest in other more specific pulmonary pharmacologic agents is now being considered as well as some way of early recognition of which baby is going to fit into which group, so that only the ones that need this treatment will get it.
D000109:Acetylcholine / Q000627:therapeutic use; D002746:Chlorpromazine / Q000627:therapeutic use; D004298:Dopamine / Q000627:therapeutic use; D004374:Ductus Arteriosus, Patent / Q000150:complications; D006548:Hernia, Diaphragmatic / Q000150:complications / Q000601:surgery; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D007231:Infant, Newborn; D007545:Isoproterenol / Q000627:therapeutic use; D009599:Nitroprusside / Q000627:therapeutic use; D011182:Postoperative Care; D011300:Preoperative Care; D011652:Pulmonary Circulation / Q000187:drug effects; D014043:Tolazoline / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D009599:Nitroprusside; D014043:Tolazoline; D007545:Isoproterenol; D000109:Acetylcholine; D002746:Chlorpromazine; D004298:Dopamine