Cyclic variations of erythropoietin excretion in a patient with congenital hypoplastic anaemia: Diamond-Blackfan syndrome.
Urinary erythropoietin excretion was followed daily during a period of one month in a child who had a congenital hypoplastic anaemia with periodic episodes of anaemia and a spontaneous increase in erythropoiesis. Erythropoietin excretion varied so that the highest value was ten times greater than the lowest one. It could be suggested that oscillations in erythropoietin prpoduction are secondary to the intermittent changes in the bone marrow. This finding could be included among a variety of oscillation phenomena that hematopoiesis exhibits.
D000741:Anemia, Aplastic / Q000151:congenital / Q000652:urine*; D002648:Child; D004921:Erythropoietin / Q000652:urine*; D005260:Female; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D013997:Time Factors
D006454:Hemoglobins; D004921:Erythropoietin