The increase in calcium binding of cardiac plasma membrane lipoprotein caused by general anesthetics and alcohol.
(1) Ca2+-binding lipoprotein was purified from dog heart plasma membrane and the effect of several general anesthetics, ethanol, and acetaldehyde on the Ca2+ binding was studied. (2) These drugs, which are known to cause myocardial depression increased the Ca2+ binding at clinically useful concentrations. (3) These results raise the possibility that these drugs, by increasing the Ca2+ binding to the plasma membrane, limit the availability of superficially located Ca2+ for excitation-contraction coupling and result in depression of myocardial contractile force.
D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002462:Cell Membrane / Q000378:metabolism; D004285:Dogs; D000431:Ethanol / Q000494:pharmacology*; D066298:In Vitro Techniques; D008074:Lipoproteins / Q000378:metabolism*; D008954:Models, Biological; D009206:Myocardium / Q000378:metabolism*; D011485:Protein Binding; D012492:Salts / Q000494:pharmacology
D000777:Anesthetics; D008074:Lipoproteins; D012492:Salts; D000431:Ethanol; D002118:Calcium