title: Subepicardial steal and reduction of myocardial oxygen consumption by adenosine.
abstract: The direct effects of adenosine on cardiac oxygen balance, hemodynamics and regional myocardial perfusion were studied in isolated canine hearts. Intracoronary infusion of adenosine produced a dose-dependent shift in the transmural distribution of coronary blood flow away from left ventricular subendocardium and a reduction in myocardial oxygen consumption (MVO2). The data suggest that adenosine may partially decrease MVO2 by a redistribution of flow from a high to low oxygen-extracting region of the myocardium.
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D004285:Dogs; D006439:Hemodynamics / Q000187:drug effects; D009206:Myocardium / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects
chemical_list: D000241:Adenosine