Mylecytan-sensitive and Mylecytan-resistant strains of inbred SPF mice.
In an attempt to induce aplasia of the bone marrow, to several strains of inbred SPF mice Mylecytan Spofa was administered. Evidence was provided that basically two groups can be differentiated: Mylecytan-resistant (C57 Black/ 10, ICR and F1 hybrid (Aph X C57 Black/ 10) and Mylecytan sensitive (CBA, C3H and Aph) strains. This fact should be taken into consideration in the interpretation of results of investigations evaluating the action of cytostatic preparations as well as when studying other relationships such as e. g. the aetiopathogenesis of aplasia of the bone marrow, etc.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002066:Busulfan / Q000008:administration & dosage / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
D002066:Busulfan