[Estrogen dependence of mammary gland tumors: the mechanisms of the disorder and the evaluation criteria].
Estrogen-dependent mammary gland tumors, induced in rats by DMBA, were found to show a high content of estradiol receptors. Among hormone-dependent tumors there were ones both with low and high content of the receptors. Loss of estrogen dependence by tumors with a high level of estradiol receptors is due to an impairment of the translocation of estradiol-receptor complexes into nuclei. Only in estrogen-dependent tumors the activity of hexokinase, pyruvate kinase and glucoso-6-phosphatedehydrogenase was changed following ovariectomy and administration of estradiol to the animals.
D000818:Animals; D002369:Castration; D004790:Enzyme Induction / Q000187:drug effects; D004958:Estradiol / Q000378:metabolism; D004967:Estrogens / Q000378:metabolism*; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000096:biosynthesis; D006593:Hexokinase / Q000096:biosynthesis; D008325:Mammary Neoplasms, Experimental / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D011770:Pyruvate Kinase / Q000096:biosynthesis; D051381:Rats; D011960:Receptors, Estrogen / Q000378:metabolism
D004967:Estrogens; D011960:Receptors, Estrogen; D004958:Estradiol; D005954:Glucosephosphate Dehydrogenase; D006593:Hexokinase; D011770:Pyruvate Kinase
Estrogenozavisimost' opukholeĭ molochnykh zhelez: mekhanizmy narusheniĭ i kriterii otsenki.