Neuronal control of acetylcholine receptor turnover rate at a vertebrate neuromuscular junction.
The turnover rate of acetylcholine receptors at neuromuscular junctions in mice increases progressively after denervation and, after 15 days, reaches a half-time of 30 z 5 hours. Denervation thus causes the clustered junctional acetylcholine receptors to assume the rapid turnover characteristic of extrajunctional receptors before innervation.
D000818:Animals; D002038:Bungarotoxins / Q000378:metabolism; D007700:Kinetics; D051379:Mice; D009046:Motor Neurons / Q000502:physiology*; D009121:Muscle Denervation; D009469:Neuromuscular Junction / Q000378:metabolism*; D011950:Receptors, Cholinergic / Q000378:metabolism*; D011978:Receptors, Nicotinic / Q000378:metabolism
D002038:Bungarotoxins; D011950:Receptors, Cholinergic; D011978:Receptors, Nicotinic