title: [Prevention and therapy of gastroduodenal stress bleeding with cimetidine].
abstract: In our intensive care unit we were able to prevent almost all bleedings from stress ulcerations in patients with insufficiency of various organs (1,6%) by administering the H2-receptor blocker cimetidine in doses of 8 X 200 mg per day. However, stress ulcer bleedings occurred in 14% of those patients also suffering from a sepsis. At lower doses of cimetidine, the rate of bleeding was comparable to that encountered in patients treated with antacids, i.e. 12,5% patients with multiple organ insufficiency and 42,7% with sepsis. Cimetidine was able to stop less extensive bleedings, but did not show any therapeutic effect in case of bleeding which led to a significant fall in hemoglobin concentration.
mesh_terms: D002927:Cimetidine / Q000627:therapeutic use*; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D010438:Peptic Ulcer Hemorrhage / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications
chemical_list: D006146:Guanidines; D002927:Cimetidine
vernacular_title: Prophylaxe und Therapie gastroduodenaler Stressblutungen mit Cimetidin.