title: Experimental occlusion of the central artery of the retina. IV: Retinal tolerance time to acute ischaemia.
abstract: Ophthalmoscopic, fluorescein angiographic, electrophysiological, and morphological studies on 63 eyes of rhesus monkeys with acute transient experimental occlusion of the central artery of the retina (OCAR) showed that the retina suffered irreparable damage after ischaemia of 105 minutes but recovered well after ischaemia of 97-98 minutes. The tolerance time of the brain to acute transient ischaemia is many times shorter than that of the retina. The metabolism of ischaemic neurones (in the retina and brain) is discussed with a view to explaining this difference, and also the various factors possibly responsible for the retina's longer tolerance to ischaemia, as compared to the brain.
mesh_terms: D000818:Animals; D001157:Arterial Occlusive Diseases / Q000378:metabolism / Q000473:pathology*; D001921:Brain / Q000378:metabolism / Q000473:pathology; D004594:Electrophysiology; D007511:Ischemia / Q000378:metabolism / Q000473:pathology; D008253:Macaca mulatta; D009474:Neurons / Q000378:metabolism; D012160:Retina / Q000378:metabolism / Q000473:pathology*; D012161:Retinal Artery; D013997:Time Factors