Splenic size and function in adult coeliac disease.
Splenic scintigraphy was performed after measurement of 99Tcm-labelled heat-damaged red cell clearance in 29 patients with treated coeliac disease. Good correlation was found between splenic size and function using these techniques. 99Tcm-labelled sulphur colloid scintiscans were also performed in 24 coeliacs. Splenic volumes computed from colloid scans correlated well with those computed from red cell scans. Almost 50% of adult patients with treated coeliac disease have impaired splenic function, the incidence rising with increasing age of starting treatment. Sulphur colloid scintigraphgy provides a simple quantitative method of assessing splenic function in treated coeliac disease which can be used in exploring the possibilities of avoidance of the adverse effects of hyposplenism.
D000328:Adult; D000367:Age Factors; D000368:Aged; D001284:Atrophy; D002446:Celiac Disease / Q000178:diet therapy / Q000503:physiopathology*; D004912:Erythrocytes; D005983:Glutens; D006358:Hot Temperature; D006801:Humans; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011877:Radionuclide Imaging; D013154:Spleen / Q000000981:diagnostic imaging / Q000473:pathology / Q000503:physiopathology*; D013667:Technetium
D013667:Technetium; D005983:Glutens