Toxicity of tri-n-butyl phosphate, with special reference to organ weights, serum components and cholinesterase activity in male rats.
Toxicity of tri-n-butyl phosphate (TBP) was investigated in male rats with special reference to body and organ weights, serum components and cholinesterase (ChE) activity. Body weights of the treated groups were significantly lower than those of the control group. There was no difference in ChE activity in the serum, but that in the brain was significantly increased in vivo. The blood coagulation time of treated groups was significantly prolonged.
D000818:Animals; D001774:Blood Chemical Analysis; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000201:enzymology; D002802:Cholinesterases / Q000032:analysis* / Q000097:blood; D004785:Environmental Pollutants / Q000633:toxicity*; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010755:Organophosphates / Q000633:toxicity*; D009943:Organophosphorus Compounds / Q000633:toxicity*; D051381:Rats; D014914:Whole Blood Coagulation Time
D004785:Environmental Pollutants; D010755:Organophosphates; D009943:Organophosphorus Compounds; C009524:tributyl phosphate; D002802:Cholinesterases