Bilateral clinical anophthalmia: drugs as potential factors.
This case of bilateral clinical anophthalmia presents a host of interrelated drug reactions and potential teratogenic factors. While none of the drugs ingested by the mother has a high teratogenic potential, drug interactions, toxic potentiation, and unknown incompatibilities cannot be excluded. Although a single etiologic agent is not incriminated, the drugs ingested during pregnancy and their toxic effects and interactions are discussed. Use of drugs during pregnancy should be limited to those clinically indicated.
D000014:Abnormalities, Drug-Induced; D000328:Adult; D000639:Amitriptyline / Q000009:adverse effects; D000853:Anophthalmos / Q000139:chemically induced*; D004025:Dicyclomine / Q000009:adverse effects; D004338:Drug Combinations; D004347:Drug Interactions; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010634:Phenobarbital / Q000009:adverse effects; D013420:Sulfamethoxazole / Q000009:adverse effects; D014295:Trimethoprim / Q000009:adverse effects
D004338:Drug Combinations; D000639:Amitriptyline; D004025:Dicyclomine; D014295:Trimethoprim; D013420:Sulfamethoxazole; D010634:Phenobarbital