title: Safety and toleration of oxymetazoline ophthalmic solution.
abstract: Two studies were carried out in volunteers without any abnormal ocular conditions to assess the effects and safety of an ophthalmic preparation of oxymetazoline (0.025%). In the first study in which oxymetazoline was compared with placebo and phenylephrine, the results of infra-red electronic pupillography showed that oxymetazoline in therapeutic doses had no effect on pupil size or near point recession. The second study, which was a double-blind forced choice comparison of two different formulations against placebo and 1% naphazoline, showed from assessments of the degree of ocular discomfort and hyperaemia that oxymetazoline was well tolerated and the subjects preferred oxymetazoline in a boric acid rather than in a phosphate solution.
mesh_terms: D000065:Accommodation, Ocular / Q000187:drug effects; D000328:Adult; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000009:adverse effects*; D008297:Male; D009883:Ophthalmic Solutions; D010109:Oxymetazoline / Q000008:administration & dosage / Q000009:adverse effects* / Q000494:pharmacology; D011680:Pupil / Q000187:drug effects
chemical_list: D007093:Imidazoles; D009883:Ophthalmic Solutions; D010109:Oxymetazoline