[Effect of the new antidepressant, inkazan, on the bioelectrical activity of the brain and conditioned reflexes].
It has been shown in experiments on cats and rabbits that the new original antidepressant inkazan--3 methyl-8-methoxy-3H,1,2,5,6-tetrahydropyrazino (1,2,3-ab)-beta-carboline hydrochloride--exerts an activating action on EEG of the brain cortex, reticular formation of the midbrain and hippocamp. Inkazan administered in small doses facilitates the inhibition of the conditioned reflexes of avoidance in rats, while the increased doses inhibit these reflexes. Inkazan has both features in common with the tricyclic antidepressants but differs from them in its effect on bioelectrical activity of the brain and on conditioned reflexes.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D002243:Carbolines / Q000494:pharmacology*; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D004924:Escape Reaction / Q000187:drug effects; D007211:Indoles / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D011930:Reaction Time / Q000187:drug effects
D000928:Antidepressive Agents; D002243:Carbolines; D007211:Indoles; C027473:metralindole
Vliianie novogo antidepressanta inkazana na bioélektricheskuiu aktivnost' mozga i uslovnye refleksy.