A study of the treatment time necessary for the vasodilator drug isoxsuprine to prevent necrosis in a skin flap.
These results show that administration of isoxsuprine at least 13 days prior to flap elevation and continuance at least 7 days postoperatively does lead to completre survival of the abdominal neurovascular island skin flap in the rat.
D000818:Animals; D004334:Drug Administration Schedule; D006085:Graft Survival / Q000187:drug effects; D007556:Isoxsuprine / Q000008:administration & dosage* / Q000627:therapeutic use; D009336:Necrosis; D011183:Postoperative Complications / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D012867:Skin / Q000473:pathology; D013524:Surgical Flaps; D013997:Time Factors
D007556:Isoxsuprine