Inhibition of isolated rat liver RNApolymerases I and II by aminoacridines.
9-Aminoacridine and 2 derivatives which contain hydroxyalkylic or aminoalkylic side chains in the 9-position totally inhibit the transcription of calf thymus DNA by rat liver RNA polymerases I and II. This inhibitory action does not always appear to be completely related to the ability of aminoacridines to intercalate into the DNA template.
D000585:Aminacrine / Q000031:analogs & derivatives / Q000494:pharmacology*; D000609:Aminoacridines / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D004247:DNA; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D011485:Protein Binding; D012318:RNA Polymerase I / Q000037:antagonists & inhibitors*; D012319:RNA Polymerase II / Q000037:antagonists & inhibitors*; D051381:Rats; D013698:Templates, Genetic; D013950:Thymus Gland
D000609:Aminoacridines; D000585:Aminacrine; D004247:DNA; D012319:RNA Polymerase II; D012321:DNA-Directed RNA Polymerases; D012318:RNA Polymerase I