A common mucosal immune system. Antibody expression in secretions following gastrointestinal stimulation.
Isoelectric focusing was used to probe the expression of IgA anti-DNP antibodies in secretions of rats receiving gastrointestinal immunization. The identity of the IgA antibody spectrotypes suggest that cells with identical clonotype potential seed various secretory surfaces following gastrointestinal stimulation. The data are discussed in terms of a common mucosal immune system linked by migrating populations of IgA precursor cells.
D000818:Animals; D004064:Digestive System / Q000276:immunology*; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D007070:Immunoglobulin A / Q000096:biosynthesis; D007413:Intestinal Mucosa / Q000276:immunology*; D007419:Intestinal Secretions / Q000276:immunology; D007525:Isoelectric Focusing; D008168:Lung / Q000276:immunology; D008892:Milk / Q000276:immunology; D011247:Pregnancy; D051381:Rats; D012463:Saliva / Q000276:immunology
D004136:Dinitrobenzenes; D007070:Immunoglobulin A