Pharmacokinetics of severe theophylline intoxication managed by peritoneal dialysis.
In a patient severely poisoned with theophylline, saturation kinetics were demonstrated at serum concentrations > 35 micrograms/ml with subsequent conversion to first order kinetics (t 1/2 = 5.4 h). Peritoneal dialysis was used to enhance the drug's removal. The mean theophylline clearance was greater for dialysate (5.11 ml/min) than for urine (1.98 ml/min) or gastric fluid (0.32 ml/min). Urinary elimination occurred as a constant first order process (t 1/2 = 4.3 h). Peritoneal dialysis is a valuable early adjunct in the management of severe theophylline intoxication.
D002675:Child, Preschool; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D006464:Hemoperfusion; D006801:Humans; D007700:Kinetics; D008657:Metabolic Clearance Rate; D010530:Peritoneal Dialysis; D013806:Theophylline / Q000378:metabolism / Q000506:poisoning*
D013806:Theophylline