Indomethacin enhancement of TPA tumor promotion in mice.
Skin tumor promotion in mice by 12-O-tetradecanoylphorbol-13-acetate (TPA) is characterized by hyperplasia and inflammation. Based on the inhibitory effect of the steroidal anti-inflammatory drugs, non-steroidal agents, such as indomethacin, were also expected to show some degree of inhibition; however, repeated tumor experiments demonstrate that indomethacin enhances TPA promotion in a dose-response manner. A time-of-application effect was evident such that indomethacin given 2 h prior to TPA resulted in the greatest enhancement. Flurbiprofen was also observed to enhance promotion slightly.
D000818:Animals; D004357:Drug Synergism; D005260:Female; D005480:Flurbiprofen / Q000009:adverse effects; D007213:Indomethacin / Q000008:administration & dosage; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D010212:Papilloma / Q000139:chemically induced*; D010704:Phorbols; D012878:Skin Neoplasms / Q000139:chemically induced*; D013755:Tetradecanoylphorbol Acetate
D010704:Phorbols; D005480:Flurbiprofen; D013755:Tetradecanoylphorbol Acetate; D007213:Indomethacin