Immunoblastic sarcoma after thymus epithelial graft in an immunodeficient child.
A 3 1/2-year-old girl with severe combined immunodeficiency received a thymus epithelial graft. After transient clinical and in vitro immunologic improvement, she developed fever, lung infiltrates and, terminally, massive gastrointestinal bleeding only 2 1/2 months after transplantation. Autopsy revealed widespread immunoblastic sarcoma involving both transplantation sites in the mesentery and thigh, lymph nodes, lung, liver, spleen and gastrointestinal tract. This B cell lymphoma was likely induced by the grafted thymus epithelium.
D002675:Child, Preschool; D004848:Epithelium / Q000637:transplantation / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000601:surgery*; D008099:Liver / Q000473:pathology; D008223:Lymphoma / Q000209:etiology* / Q000473:pathology; D009336:Necrosis; D013154:Spleen / Q000473:pathology; D013950:Thymus Gland / Q000637:transplantation* / Q000648:ultrastructure; D014184:Transplantation, Homologous