[Modeling the kinetics of regeneration of nonhomogeneous populations of hematopoietic cells during antitumor therapy].
On the basis of a mathematical model imitating known properties of stem blood-forming cells regeneration of these cells was studied under the conditions of antitumor therapy depending on the regime of cytostatics introduction. Metotraxat and vinblastin preparations taken as an example, a principal possibility for theoretical analysis of toxic influence of cytotoxic therapy on stem hemopoietic cells was shown as well as modification of the schemes of introduction of antitumor preparations for decreasing their suppressing effect on hemopoiesis. Possible application of kinetic modelling of regeneration of the pool of stem hemopoietic cells for preclinical selection of the schemes of antitumor therapy, taking into account their effect on the hemopoiteic system is discussed.
D002453:Cell Cycle; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells; D006801:Humans; D007700:Kinetics; D008433:Mathematics; D008727:Methotrexate / Q000009:adverse effects*; D008954:Models, Biological; D009369:Neoplasms / Q000188:drug therapy / Q000503:physiopathology; D012038:Regeneration; D014747:Vinblastine / Q000009:adverse effects*
D014747:Vinblastine; D008727:Methotrexate
Modelirovanie kinetiki regeneratsii neodnorodnykh populiatsiĭ krovetvornykh kletok v usloviiakh protivoopukholevoĭ terapii.