title: Response of the lung airway to exercise testing in asthma and rhinitis.
abstract: The reactivity of the large and small airways of the lung in a group of ten atopic subjects with rhinitis was compared with that in ten non-atopic control subjects and in 17 with atopic asthma. Atopic state was assessed by skin prick testing with 22 common allergens and by measurement of total serum immunoglobulin E (IgE) antibody. The atopic state of the rhinitis and asthma patients was similar. Exercise provocation tests were performed on each subject and changes in airway function were measured by peak expiratory flow rate, forced expiratory volume in one second, vital capacity, maximal expiratory flow volume curves and closing volume. There were no statistically significant differences between the changes in lung function after exercise in the rhinitis patients compared with the controls. There were, however, statistically significant changes in all the measurements of respiratory function in those with asthma compared with the other two groups. The falls in forced expiratory flow rates in the asthmatic subjects were greater at lower lung volumes than near the total lung capacity, perhaps indicating that narrowing of small, as well as large, airways was occurring. No correlation was found between the magnitude of the airway response to exercise and either the total serum IgE antibody or the mean weal diameter of positive skin tests in each subject. Atopic subjects with rhinitis but not asthma showed no evidence of bronchial hyper-reactivity on exercise testing. It is therefore suggested that single exercise provocation test can discriminate subjects with atopic asthma from those with other atopic disorders.
mesh_terms: D000328:Adult; D001249:Asthma / Q000276:immunology / Q000503:physiopathology*; D005540:Forced Expiratory Flow Rates; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D008168:Lung / Q000503:physiopathology*; D008297:Male; D005082:Physical Exertion; D012129:Respiratory Function Tests; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology / Q000503:physiopathology*; D012882:Skin Tests
chemical_list: D007073:Immunoglobulin E