Neural and humoral factors in postoperative ileus.
Two inhibitory mechanisms in the human colon which may contribute to postoperative ileus have been studied. Dopamine, a possible peripheral neurotransmitter, inhibited isolated colonic smooth muscle strips by a direct effect in longitudinal muscle any by a nerve-mediated mechanism as circular muscle. Plasma motilin levels were suppressed pre- and per- operatively and elevation of levels postoperatively correlated with the return of normal motility and the severity of the operation.
D002763:Cholecystectomy; D003106:Colon / Q000502:physiology; D004298:Dopamine / Q000494:pharmacology / Q000502:physiology; D004576:Electromyography; D059685:Herniorrhaphy; D006801:Humans; D066298:In Vitro Techniques; D007415:Intestinal Obstruction / Q000097:blood / Q000503:physiopathology*; D009037:Motilin / Q000097:blood; D009119:Muscle Contraction / Q000187:drug effects; D011183:Postoperative Complications / Q000097:blood / Q000503:physiopathology*; D011312:Pressure
D009037:Motilin; D004298:Dopamine