title: Altered [65Zn]chloride accumulation by aged rats' adipocytes in vitro.
abstract: Accumulation of [65Zn]chloride by isolated adipocytes from rats 11-13 months and 23-25 months old was investigated in vitro. While size and total protein per cell did not differ at the two ages, uptake of 65Zn was depressed 40% in the adipocytes of the older animals. In contrast, serum zinc concentration was reduced marginally (15%) in the older rats. Our results suggest that altered cellular zinc metabolism may be part of the aging process.
mesh_terms: D000273:Adipose Tissue / Q000166:cytology / Q000378:metabolism*; D000375:Aging; D000818:Animals; D002712:Chlorides; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D051381:Rats; D015032:Zinc / Q000097:blood / Q000378:metabolism*; D017967:Zinc Compounds
chemical_list: D002712:Chlorides; D017967:Zinc Compounds; C016837:zinc chloride; D015032:Zinc