The effect of aflatoxin B1 on translation in cells in culture.
The effect of aflatoxin B1 (AFB1) upon translation has been studied in two cell lines in culture, which differ markedly in their sensitivity to the toxin. It was found that AFB1 predominantly inhibits initiation of translation in both cell lines.
D000348:Aflatoxins / Q000494:pharmacology*; D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D007668:Kidney; D011132:Polyribosomes / Q000187:drug effects; D014176:Protein Biosynthesis / Q000187:drug effects*; D051381:Rats; D012270:Ribosomes / Q000378:metabolism; D013045:Species Specificity
D000348:Aflatoxins