[Clinico-pharmacological investigation of an oral form of a depot preparation on silicone resin base with indomethacin as the active ingredient].
Indomethacin depot tablets on the basis of silicon resin were investigated in a clinical pharmacological study including pharmacokinetic data on 20 patients with rheumatoid arthritis. Effects and side-effects of the depot tablet are equal to those of the standard Metindol-capsules. After depot tablets serum indomethacin level is in the therapeutic range for 8--12 hours so that drug administration is reduced to twice daily.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D003692:Delayed-Action Preparations; D006801:Humans; D007213:Indomethacin / Q000097:blood / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D007213:Indomethacin
Klinisch-pharmakologische Untersuchung einer oralen Depotarzneiform auf Silikonharzbasis mit Indometazin als Wirkstoff.