[Rat postnatal development after bonafton exposure].
The first generation progeny of rats received days 10-13 of pregnancy a new antiviral drug bonaphthon (400 mg/kg) which exerts a toxic effect on females. The progeny did not show postnatal death or reduction of the life span. Moreover, no impairment of muscle work capacity, basal metabolism, cardiovascular system, peripheral blood parameters, or changes in the function of organs and systems were recorded. Morphological and functional deviations in the liver of 2-month-old progeny were unstable and got repaired by 3 months of age.
D000818:Animals; D000831:Animals, Newborn; D000998:Antiviral Agents / Q000633:toxicity*; D001481:Basal Metabolism / Q000187:drug effects; D001769:Blood / Q000187:drug effects; D005260:Female; D005865:Gestational Age; D006128:Growth / Q000187:drug effects*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D009285:Naphthoquinones / Q000633:toxicity*; D009949:Orientation / Q000187:drug effects; D011247:Pregnancy; D051381:Rats
D000998:Antiviral Agents; D009285:Naphthoquinones; C011180:bonafton
Postnatal'noe razvitie krys posle vozdeĭstviia bonaftona.