[Separation and study of two serum factors involved in the inhibition of the maternal cytotoxic reaction against embryonic cells in pregnant salamandra (author's transl)].
In vitro experiments in pregnant salamanders show a maternal specific cytotoxic reaction against larvae cells and an inhibition of this reaction by maternal serum. The last one is double: non-specific inhibition of maternal cellular reaction and specific protection of embryonic cells. Two fractions have been isolated from maternal serum, with biological properties in cell cultures: the first one is a protein (migrating as alpha2-macroglobulin does) which is implied in non-specific immunosuppression of maternal cells; the second fraction contains an IgM and specifically protects embryonic cells against maternal cytotoxicity.
D000818:Animals; D001798:Blood Proteins / Q000276:immunology* / Q000302:isolation & purification; D003602:Cytotoxicity, Immunologic; D004625:Embryo, Nonmammalian / Q000276:immunology*; D005260:Female; D008297:Male; D011247:Pregnancy; D012454:Salamandra
D001798:Blood Proteins
Séparation et étude de deux facteurs sériques responsables de l'inhibition de la réaction cytotoxique maternelle à l'égard des cellules embryonnaires, chez la salamandre gestante.