Phenaceturic acid, a new urinary metabolite of styrene in the rat.
1. After administration of styrene to rat, phenaceturic acid, a new metabolite, was isolated. After administration of d8-styrene to rat, deuterium-labelled phenaceturic acid was excreted in the urine. 2. Two metabolic pathways are proposed, based on mass spectra of the deuterium-labelled phenaceturic acid. 3. After a single dose of styrene (250 mg/kg), the excreted phenaceturic acid originating from styrene in the urine amounted to 1.4% dose.
D000818:Animals; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D005260:Female; D005998:Glycine / Q000031:analogs & derivatives* / Q000652:urine; D010648:Phenylacetates / Q000652:urine; D051381:Rats; D013343:Styrenes / Q000378:metabolism*
D010648:Phenylacetates; D013343:Styrenes; C022050:phenylacetylglycine; D005998:Glycine