[Effect of ampicillin and rifampicin on biochemical and immunological processes in the organs of immunized animals].
The effect of semisynthetic antibiotics, such as ampicillin and rifampicin on activity of succinate dehydrogenase (SDH) in the liver and spleen of mice immunized with heated typhoid vaccine was studied. The study showed that the average therapeutic dose of ampicillin, i.e. 50 mg/kg administered intramuscularly to the animals before and during the immunization increased the SDH activity in the spleen tissue by the 5th day. In the liver ampicillin markedly suppressed the enzyme activity over this period, while by the 10th day the level of SDH increased. The plasmocytic reaction in the spleen of the animals was also suppressed. The plasmoblast and immature plasmatic cells were especially sensitive to ampicillin. Rifampicin administered per os to albino mice in a dose of 50 mg/kg according to the same scheme as ampicillin had no effect on the activity of SDH in the liver and spleen, while the proliferative processes in the spleen of these animals decreased.
D000667:Ampicillin / Q000494:pharmacology*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D004789:Enzyme Activation / Q000187:drug effects; D007114:Immunization; D008099:Liver / Q000201:enzymology; D051379:Mice; D012293:Rifampin / Q000494:pharmacology*; D013154:Spleen / Q000201:enzymology; D013385:Succinate Dehydrogenase / Q000378:metabolism; D013997:Time Factors
D000667:Ampicillin; D013385:Succinate Dehydrogenase; D012293:Rifampin
Vliianie ampitsillina i rifampitsina na biokhimicheskie i immunologicheskie protsessy v organakh immunizirovannykh zhivotnykh.