Dendritic alterations in rat isocortex within an iron-induced chronic epileptic focus.
Ferrous chloride was injected into the rat isocortex in 5-microliters volumes as an aqueous solution with a concentration of 100 mM. Bursts of epileptiform discharges were sustained throughout the 6 weeks of observation. Nissl and Golgi-Cox stains showed gliosis and neuronal loss within the injection site. Neurons adjacent to the cavitory lesion showed deformity of dendrites, dendritic nodularity, loss of spines, and string-of-beads deformity. These changes are identical to those found in human epileptogenic foci.
D000818:Animals; D001921:Brain / Q000502:physiology; D002540:Cerebral Cortex / Q000648:ultrastructure; D003712:Dendrites / Q000648:ultrastructure*; D004569:Electroencephalography; D007501:Iron / Q000494:pharmacology; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000473:pathology* / Q000503:physiopathology
D007501:Iron