title: Effects of oral contraceptives containing 50 microgram estrogen on blood coagulation in non-Caucasian women.
abstract: In one of the first longitudinal studies of 163 non-Caucasian women, comprehensive coagulation, fibrinolysis and platelet function tests were performed before and during 24 months of oral contraceptive pill usage containing 50 microgram estrogen. Results of this ongoing study indicate a state of abnormal coagulability with increase in fibrinogen, prothrombin, Factor V and Factor X. There was also a decrease in antithrombin III level. There was a shortening of overall clotting parameters measured by prothrombin time and Kaolin cephalin time. The significance of these changes in the aetiology of thromboembolism is discussed.
mesh_terms: D044466:Asian People; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests; D003276:Contraceptives, Oral / Q000009:adverse effects*; D005260:Female; D006801:Humans; D010979:Platelet Function Tests; D012846:Singapore
chemical_list: D003276:Contraceptives, Oral