title: Constituents of Egyptian Euphorbiaceae. IX. Irritant and cytotoxic ingenane esters from Euphorbia paralias L.
abstract: The irritant and cytotoxic constituents of the latex of Euphorbia paralias L. were separated from the hydrocarbon fraction by means of solvent partition. 3 new ingenane esters were identified from the toxic ether fraction. The major compound was 3-angelyl-20-deoxyingenol and the 2 minor compounds were 3-hexanoyl-20-deoxyingenol and 3-angelyl-ingenol. These compounds were of a similar potency to podophyllin in the inhibition of 3H-thymidine uptake by TLX/5 mouse lymphoma cells. In addition the compounds produced a persistent erythema of the mouse ear in sub-microgram doses.
mesh_terms: D000818:Animals; D004224:Diterpenes / Q000032:analysis*; D007509:Irritants / Q000032:analysis* / Q000633:toxicity; D013058:Mass Spectrometry; D051379:Mice; D010944:Plants / Q000032:analysis*
chemical_list: D004224:Diterpenes; D007509:Irritants