Thioacetamide and benzo(a)pyrene--induced alterations of the intrinsic viscosity of hepatocyte chromatin.
The nuclear hepatocytic chromatin showed to be sensitive to the harmful effects of thioacetamide (TAA) and benzo(a)pyrene (BP), a hepatic and a nonhepatic carcinogen. Intrinsic viscosity is a reliable indicator of the drug-induced chromatin changes. A single dose of TAA induced a reversible alteration of viscosity, but the same kind of treatment using BP resulted in persistent changes. The reasons of the different behaviour of chromatin, when subjected to the action of the mentioned carcinogens, are discussed.
D000081:Acetamides / Q000009:adverse effects*; D000818:Animals; D001580:Benzopyrenes / Q000009:adverse effects*; D002843:Chromatin / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013853:Thioacetamide / Q000009:adverse effects*
D000081:Acetamides; D001580:Benzopyrenes; D002843:Chromatin; D013853:Thioacetamide