title: Effect of guar gum on body weight and serum lipids in hypercholesterolemic females.
abstract: The effect of guar gum (15 g/day) on serum lipids and body weight of middle-aged hypercholesterolemic females was studied in a double-blind controlled trial. No consistent changes were observed in serum cholesterol, triglycerides or HDL cholesterol in patients taking guar gum, placebo or no medication at all. A highly significant decrease in body weight (62.9 +/- 2.1 vs. 60.4 +/- 2.2 kg, p < 0.0005, paired comparison) was seen in subjects receiving guar gum, whereas body weight remained constant in the other two groups. It is concluded that the daily ingestion of 15 g of guar gum results in a permanent weight loss, but does not influence serum lipids in females with hypercholesterolemia.
mesh_terms: D001835:Body Weight / Q000187:drug effects*; D002784:Cholesterol / Q000097:blood; D004311:Double-Blind Method; D005260:Female; D005685:Galactans / Q000494:pharmacology*; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood* / Q000178:diet therapy; D008055:Lipids / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood; D008351:Mannans / Q000494:pharmacology*; D008875:Middle Aged; D010919:Placebos; D053149:Plant Gums; D011134:Polysaccharides / Q000494:pharmacology*; D011897:Random Allocation; D013997:Time Factors; D014280:Triglycerides / Q000097:blood
chemical_list: D005685:Galactans; D008055:Lipids; D008075:Lipoproteins, HDL; D008351:Mannans; D010919:Placebos; D053149:Plant Gums; D011134:Polysaccharides; D014280:Triglycerides; D002784:Cholesterol; C007894:guar gum