Chemotaxis in yersinia arthritis. HLA-B27 positive neutrophils show high stimulated motility in vitro.
Chemotaxis, chemokinesis, and spontaneous locomotion of polymorphonuclear leukocytes (PMNs) of yersinia arthritis (YA) patients and healthy subjects with or without HLA-B27 were studied by agarose assay and membrane filter technique. HLA-B27 positive healthy control subjects and yersinia patients showed significantly higher response to chemotactic stimulus than HLA-B27 negative controls. Consequently, the high response was associated with HLA-B27 irrespective of YA. The high responder PMNs may contribute to the more severe inflammatory symptoms in YA patients with HLA-B27.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001170:Arthritis, Infectious / Q000276:immunology*; D002465:Cell Movement; D002634:Chemotaxis, Leukocyte; D005260:Female; D006680:HLA Antigens; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000276:immunology; D012685:Sepharose; D013997:Time Factors; D015009:Yersinia Infections / Q000276:immunology*; D015054:Zymosan / Q000494:pharmacology
D006680:HLA Antigens; D015054:Zymosan; D012685:Sepharose