Plasma levels of isosorbide dinitrate and the isosorbide mononitrates after increasing doses of a retard preparation of isosorbide dinitrate.
Different doses of a retard preparation of isosorbide dinitrate (40, 80 and 120 mg) were given in a cross-over design with one week intervals to 6 patients with angina pectoris. Plasma concentrations of isosorbide dinitrate and of the isosorbide 2- and 5-mononitrates were measured by a gas-liquid chromatographic method. The concentrations of isosorbide dinitrate rose with the dose given, and with the highest dose, levels above 5 ng/ml were obtained for 12 hours. Concentrations of the mononitrates were much higher than those of the parent compound.
D000787:Angina Pectoris / Q000188:drug therapy; D001711:Biotransformation; D003692:Delayed-Action Preparations; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage* / Q000097:blood / Q000627:therapeutic use
D003692:Delayed-Action Preparations; D007548:Isosorbide Dinitrate