[Dynamics of the proliferative activity of aortic cells in the process of the formation of an atherosclerotic plaque].
It was demonstrated by 3H-thymidine histoautoradiography that after 3 weeks of a cholesterol diet the number of labelled endothelial and subendothelial cells in the aorta of rabbits increases sharply. With the gradual development of experimental atherosclerosis (after 6 weeks of the experiment) two types of atherosclerotic patches are found in the aorta, which differe one from the other in the degree of "maturation" and the character of distribution of the proliferating cells. Experiments with "setting apart" of the 3H-thymidine label show clearly the possibility of transformation of the subendothelial cells into lipid macrophages. The main growth of the cell mass of the atherosclerotic patch, however, occurs because the lipid macrophages themselves proliferate. The hypothesis claiming that the subendothelial cells are the precursors of all cell elements forming the patch is discussed.
D000818:Animals; D001011:Aorta / Q000503:physiopathology*; D001161:Arteriosclerosis / Q000209:etiology* / Q000503:physiopathology; D002455:Cell Division; D004036:Diet, Atherogenic; D008297:Male; D011817:Rabbits; D013997:Time Factors
Izuchenie dinamiki proliferativnoĭ aktivnosti kletok aorty v protsesse obrazovaniia ateroskleroticheskoĭ bliashki.