Buprenorphine in postoperative pain: results in 7500 patients.
Buprenorphine, a partial opiate-receptor agonist with potent analgesic properties, was given to 7548 patients in the immediate postoperative period. Ninety per cent of patients had good or adequate pain relief for at least 4 hours; there were few adverse effects and the incidence of drug-associated respiratory depression was estimated at less than 1%. There were no other side-effects of clinical note.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002047:Buprenorphine / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009019:Morphinans / Q000627:therapeutic use*; D009325:Nausea / Q000139:chemically induced; D010149:Postoperative Pain / Q000188:drug therapy*; D012131:Respiratory Insufficiency / Q000139:chemically induced; D013997:Time Factors; D014839:Vomiting / Q000139:chemically induced
D009019:Morphinans; D002047:Buprenorphine