title: Adult vitelliform macular degeneration: diagnosis and natural history.
abstract: True vitelliform dystrophy rarely appears in the adult population. We describe 10 cases in adults of bilateral vitelliform lesions clinically mistaken for Best's disease. Fluorescein angiography is a useful tool in distinguishing this dystrophy from Best's disease or other diseases. The angiographic findings suggest pigment epithelial disease. Adult vitelliform degeneration may lead to dry atrophic macular degeneration in a similar fashion as macular drusen. Symptoms and visual findings in these patients are fairly stable, and may be only slowly progressive in spite of ophthalmoscopic and fluorescein angiographic changes over a period of years. The electro-oculogram is useful in separating adult vitelliform macular degeneration from true vitelliform dystrophy.
mesh_terms: D000328:Adult; D000368:Aged; D003937:Diagnosis, Differential; D005260:Female; D005451:Fluorescein Angiography; D006801:Humans; D008268:Macular Degeneration / Q000175:diagnosis*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014792:Visual Acuity