Analgesic nephropathy induced by common proprietary mixtures.
Renal papillary necrosis has been induced in 36.4% to 75% of rats which were gavage-fed with analgesic mixtures containing proprietary combinations of aspirin, paracetamol, phenacetin, phenazone, salicylamide and caffeine. These findings support the recent recommendations of the National Health and Medical Research Council which suggest that the free availability of analgesic mixtures be restricted.
D000082:Acetaminophen / Q000009:adverse effects; D000700:Analgesics / Q000009:adverse effects*; D000818:Animals; D000983:Antipyrine / Q000009:adverse effects; D002110:Caffeine / Q000009:adverse effects; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007681:Kidney Papillary Necrosis / Q000139:chemically induced*; D004366:Nonprescription Drugs; D010615:Phenacetin / Q000009:adverse effects; D051381:Rats; D012457:Salicylamides / Q000009:adverse effects; D019966:Substance-Related Disorders
D000700:Analgesics; D004338:Drug Combinations; D004366:Nonprescription Drugs; D012457:Salicylamides; D000082:Acetaminophen; D002110:Caffeine; D010615:Phenacetin; D000983:Antipyrine