[immunohistologic findings of kidney biopsies in Wilson's disease].
12 patients with Wilson's disease were examined by means of renal biopsy. In 9 of these patients a slight (4 patients) or a strong proteinuria (5 patients) appeared during the therapy with D-penicillamine. A biopsy was performed in 3 patients before the beginning of the therapy with D-penicillamine. The patients with severe proteinuria showed the largest immunohistological changes (partly distinct immune complex nephritis with epimembranous IgG- and complement-(C3-) depositions -- electronoptically membranous glomerulonephritis. In rebiopsy after a stoppage of the medicament of 1 year only a slight tendency to improvement was to be recognized.
D001706:Biopsy; D003176:Complement C3 / Q000032:analysis; D006527:Hepatolenticular Degeneration / Q000150:complications / Q000188:drug therapy / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007668:Kidney / Q000276:immunology* / Q000473:pathology; D010396:Penicillamine / Q000627:therapeutic use; D011507:Proteinuria / Q000209:etiology
D003176:Complement C3; D007074:Immunoglobulin G; D010396:Penicillamine
Immunhistologische Befunde an Nierenbiopsien bei Morbus Wilson.