title: Importance of Solcoseryl in infertility. 2. Effects of Solcoseryl with pathological spermiogram findings in vivo.
abstract: 44 patients with different spermiogram findings were treated with Solcoseryl¿ (Messrs. Solco, Basel, Switzerland). Among the findings were 39 cases of oligozoospermia, 26 cases of asthenozoospermia and 7 cases of hypospermia. 20 subjects had already received other treatment without success. Treatment in these 20 cases had been terminted at least six months prior to our studies. All patients received 10 injections comprising 1 ampule each of Solcoseryl¿ at intervals of 1 day with breaks at the weekends. The spermiograms were analysed upon completion of treatment and two weeks, four weeks, three months and six months after completion of treatment. The effects of Solcoseryl¿ proved to be completely independent of previous treatment. The most noticeable improvement in he findings following Solcoseryl¿ application was the sperm count. This effect was observed already upon completion of treatment and reached a maximum two weeks later. The effect then decreased. In a few cases, however, sperm numbers continued to decline for up to two weeks after therapy before subsequently increasing. The findings for 44% of the patients with asthenozoospermia were at least temporarily normal after the treatment. In a few of these patients, however, the number of dead sperm also increased immeditely after therapy. Severe cases of asthenozoospermia were not influenced by Solcoseryl¿ treatment. Improvement was also found in the case of hypospermia. In view of the objective improvement of the parameters of the ejaculate and the fact that gravidity has so far occurred in 11 (25%) of the wives of the patients treated with Solcoseryl¿ (in some cases after the first three-monthly examination), attempted treatment with Solcoseryl¿ is recommended.
mesh_terms: D000183:Actihaemyl / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000188:drug therapy*; D008297:Male; D009845:Oligospermia / Q000188:drug therapy*; D011247:Pregnancy; D013076:Sperm Count; D014020:Tissue Extracts / Q000627:therapeutic use*
chemical_list: D014020:Tissue Extracts; D000183:Actihaemyl
vernacular_title: Zur Bedeutung des Solcoseryl¿ bei Infertilität*) --- 2.(Mitteilung:) Die Wirkung von Solcoseryl¿ bei pathologischen Spermiogrammbefunden in vivo.