Antibacterial and antifungal activity of liriodenine and related oxoaporphine alkaloids.
Liriodenine was evaluated for its antibacterial and antifungal activity against several microorganisms. Other related oxoaporphine alkaloids also were evaluated. Attempts to prepare oxoaporphine alkaloids from N-acetylnoraporphines were unsuccessful, but an unexpected phenanthrene alkaloid was obtained. A novel N-demethylation reaction was noted when oxogaucine methiodide and liriodenine methiodide were treated with alumina.
D000470:Alkaloids / Q000138:chemical synthesis / Q000494:pharmacology*; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001060:Aporphines / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D009090:Mucorales / Q000187:drug effects; D014249:Trichophyton / Q000187:drug effects
D000470:Alkaloids; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D001060:Aporphines; C026980:liriodenine