title: The effect of in vitro irradiation on mitogenic responsiveness of peripheral blood lymphocytes from patients with untreated and cured Hodgkin's disease.
abstract: Blood lymphocytes from 10 untreated patients with active Hodgkin's disease were compared with those of 10 cured patients with regard to the responsiveness of the cells to PHA and Con A following in vitro irradiation. Lymphocytes of patients remaining in long-term remission exhibited the same pattern of radiosensitivity as those of healthy donors: there was one relatively radiosensitive cell population and one relatively resistant. The latter cell population was undetectable in patients with an active disease. Reappearance of the radioresistant PHA and Con A reactive cell fractions might thus be associated with remission.
mesh_terms: D000328:Adult; D000368:Aged; D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004307:Dose-Response Relationship, Radiation; D006689:Hodgkin Disease / Q000532:radiotherapy*; D006801:Humans; D008213:Lymphocyte Activation / Q000528:radiation effects*; D008875:Middle Aged; D012075:Remission, Spontaneous
chemical_list: D003208:Concanavalin A