The effect of cycloheximide and carbon tetrachloride in Ehrlich ascites tumour-bearing mice.
Treatment with cycloheximide and a hepatotoxic dose of CCl4 (well tolerated in normal animals) is acutely toxic in animals bearing the Ehrlich ascites tumour. Reduction in tumour load 4 hr after the administration of cycloheximide and CCl4 is life-saving: treatment with a hepatotoxic dose of CCl4 30 hr before challenge with cycloheximide and CCl4 also nullifies that otherwise life-threatening treatment.
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism* / Q000473:pathology; D056486:Chemical and Drug Induced Liver Injury; D003513:Cycloheximide / Q000494:pharmacology*; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009336:Necrosis; D014176:Protein Biosynthesis
D003513:Cycloheximide; D002251:Carbon Tetrachloride