Pharmacokinetics and taste acceptance of an alcohol-free oxtriphylline solution.
As follow-up to earlier studies done on the pharmacokinetics of theophylline preparations in young children, an alcohol-free oxtriphylline syrup preparation was studied. Oxtriphylline syrup demonstrated no appreciable change in the pharmacokinetic parameter of half-life in this young age group. Therapeutic dose relationship were studied in conjunction with trough level measurements. Patient acceptance of this preparation is judged to be excellent.
D001249:Asthma / Q000188:drug therapy*; D002675:Child, Preschool; D002794:Choline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D000431:Ethanol; D005260:Female; D006207:Half-Life; D006801:Humans; D007223:Infant; D007700:Kinetics; D008297:Male; D012996:Solutions; D013649:Taste / Q000187:drug effects*; D013806:Theophylline / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism / Q000627:therapeutic use
D012996:Solutions; C012839:cholinophyllin; D000431:Ethanol; D013806:Theophylline; D002794:Choline