title: In vivo comparison of triamcinolone and beclomethasone inhalation delivery systems.
abstract: The efficiencies of two metered dose delivery systems designed for oral inhalation of glucocorticoids (triamcinolone acetonide and beclomethasone dipropionate) were compared in an open-labeled, randomized, crossover fashion in 18 asthmatic patients. Measurements were made of the mean amount of glucocorticoid released per actuation at the aerosol valve of each delivery system, the mean amount in a post-dose gargle and saliva specimen and the mean amount that remained in the oral adapter after use of each system. Retention in the oropharyngeal cavity was 7.3% and 40.3% of delivered dose for the triamcinolone acetonide and beclomethasone dipropionate systems (P < 0.001). The amount of glucocorticoid potentially available to the bronchial airways was 92.7% of the delivered dose for the triamcinolone acetonide and 59.7% for the beclomethasone dipropionate system.
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000336:Aerosols; D000368:Aged; D001249:Asthma / Q000188:drug therapy; D001507:Beclomethasone / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D004305:Dose-Response Relationship, Drug; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D008875:Middle Aged; D014222:Triamcinolone Acetonide / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
chemical_list: D000336:Aerosols; D014222:Triamcinolone Acetonide; D001507:Beclomethasone