Pulmonary alveolar proteinosis in two siblings with decreased immunoglobulin A.
A brother and sister with classic, biopsy proved pulmonary alveolar proteinosis are described. Both had low serum and low normal secretory immunoglobulin A (IgA) levels. A tendency for familial occurrence is possible and it is recommended that patients with pulmonary alveolar proteinosis, and their families, be evaluated for immunologic deficiencies.
D000293:Adolescent; D000328:Adult; D004406:Dysgammaglobulinemia / Q000175:diagnosis / Q000235:genetics*; D005260:Female; D006801:Humans; D017098:IgA Deficiency; D007070:Immunoglobulin A / Q000032:analysis; D008297:Male; D011649:Pulmonary Alveolar Proteinosis / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D011650:Pulmonary Alveoli / Q000000981:diagnostic imaging / Q000473:pathology; D011653:Pulmonary Diffusing Capacity; D011859:Radiography; D007507:Therapeutic Irrigation; D014797:Vital Capacity
D007070:Immunoglobulin A