title: Evidence of a direct action of angiotensin II on neurones in the septum and in the medial preoptic area.
abstract: Angiotensin II (AII) was microiontophoretically applied on neurones located in the septum and the medial preoptic area (MPOA). All the septal neurones sensitive to AII (15/37) responded by an inhibition to the peptide application. Of 44 units tested in the MPOA 21 cells (48%) were sensitive to AII and responded either by an increase (11/21) or decrease (10/21) in their firing. The specificity of these responses were ascertained by simultaneous application of the antagonist Sar-Ile-Angiotensin II. These data suggest that Angiotensin II acts directly on neurones of the septum and medial preoptic area, structures implicated in the control of drinking behaviour.
mesh_terms: D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D005260:Female; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D011301:Preoptic Area / Q000187:drug effects*; D051381:Rats
chemical_list: D000804:Angiotensin II; D015059:1-Sarcosine-8-Isoleucine Angiotensin II