[Efficency of tocoylsis by fenoterol and fenoterol in combination with a beta-1-blocking compound (author's transl)].
In 35 pregnant women threatening premature labour and cervic dilatation indicated therapy by a beta-mimetic compound (fenoterol) for tocolysis. 17 patients (group I) got fenoterol-monotherapy; in 18 patients (group II) fenoterol was combined with the cardioselective beta-1-blocking agent metoprolol. There were no differences in age, bodyweight and time of gestation in both groups before therapy; also the obstetric states--as compared by pelvic score (Bishop) and tocolysis index (Baumgarten)--were nearly identical. Efficiency of tocolytic therapy was evaluated by prolongation index (Richter) and tocolysis-success-score (Weidinger). Statistical analysis comparing these parameters in both groups showed no significant differences. Heartrate, however, was significantly (p > 0,005) lower in patients treated by fenoterol and metoprolol, thus indicating less cardial stress induced by fenoterol. In conclusion the combination of the semiselective beta-2-stimulating compound fenoterol with the beta-1-blocking agent metoprolol is proposed for tocolytic therapy because of less cardial stress but identical tocolytic efficiency as compared with fenoterol-monotherapy.
D004359:Drug Therapy, Combination; D004983:Ethanolamines / Q000627:therapeutic use*; D005260:Female; D005280:Fenoterol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008790:Metoprolol / Q000008:administration & dosage / Q000627:therapeutic use*; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D011247:Pregnancy; D011412:Propanolamines / Q000627:therapeutic use*; D013997:Time Factors
D004983:Ethanolamines; D011412:Propanolamines; D005280:Fenoterol; D008790:Metoprolol
Tokolyseerfolge unter Fenoterol-Monotherapie und Fenoterol in Kombination mit einem kardioselektiven beta-Blocker.