Taurine selectivity antagonizes L-kynurenine-produced seizures in mice.
Taurine in doses of 100 and 200 mg/kg (intraperitoneally) and 2.5 micrograms (into brain ventricles) antagonized clonic seizures produced by L-kynurenine sulfate injected into brain ventricles of SHR adult male albino mice. Seizures produced by another metabolite of tryptophan in the kynurenine pathway, quinolinic acid, were intensified. The convulsant effects of strychnine, pentylenetetrazol and thiosemicarbazide was not modified.
D000818:Animals; D004336:Drug Antagonism; D007737:Kynurenine; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine; D007737:Kynurenine