title: Who is afraid of carcinogens?
abstract: The reevaluation of previously reported studies in carcinogenesis indicates the existence of a mechanism which protects mice from the carcinogenic hazard, Mice had been subjected to ultraviolet radiation (U.V.), applied at regular doses and intervals (10). The time from the first application to the appearance of a 100 mm3 sized tumor was defined as "development time" td. The td times had been found to be distributed lognormally. Such a distribution indicates that the magnitude of td is proportional to the carcinogenic exposure which means that the longer a mouse is exposed to U.V. the slower the progression of its neoplasms. This may be evident also from the lognormal risk function or conditional failure rate lambda (td) which initially rises in these animals to a maximum, whereupon it declines. The declining risk function supports the existence of a protective mechanism in the body which withstands carcinogenesis.
mesh_terms: D000818:Animals; D002273:Carcinogens; D004195:Disease Models, Animal; D006801:Humans; D007113:Immunity, Innate; D008297:Male; D009369:Neoplasms / Q000276:immunology / Q000503:physiopathology*; D009374:Neoplasms, Experimental / Q000209:etiology; D009381:Neoplasms, Radiation-Induced / Q000209:etiology; D051381:Rats; D012878:Skin Neoplasms / Q000209:etiology; D014466:Ultraviolet Rays
chemical_list: D002273:Carcinogens