Haemostatic platelet plug formation in the isolated rabbit mesenteric preparation--an analysis of red blood cell participation.
In a model using an isolated rabbit mesenteric preparation microvessels were transected and the time until haemostatic plugs formed was registered. Perfusion of platelet rich plasma gave no haemostasis whereas whole blood did. Addition of chlorpromazine or adenosine to the whole blood significantly prolonged the time for haemostasis, and addition of ADP to the platelet rich plasma significantly shortened it. It is concluded that red cells are necessary for a normal haemostasis in this model, probably by a combination of a haemodynamic and ADP releasing effect.
D000079:Acetaldehyde / Q000494:pharmacology; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D001081:Apyrase / Q000494:pharmacology; D001792:Blood Platelets / Q000502:physiology*; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D006487:Hemostasis; D008297:Male; D008638:Mesenteric Arteries; D008642:Mesenteric Veins; D011817:Rabbits; D013997:Time Factors
D000244:Adenosine Diphosphate; D001081:Apyrase; D000079:Acetaldehyde