Drug metabolism and liver function after methyldopa withdrawal.
1 The effects of methyldopa withdrawal on liver function and drug metabolism were investigated in ten elderly females suffering from the drug-induced orthostatic reaction and resistant hypertension. 2 There was a significant increase in serum albumin level, antipyrine metabolism and urinary excretion of D-glucaric acid 6 months after the methyldopa withdrawal. 3 The results suggest that patients treated with methyldopa might show a reduced metabolizing ability in spite of normal liver function tests.
D000367:Age Factors; D000368:Aged; D005260:Female; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008111:Liver Function Tests; D008750:Methyldopa / Q000009:adverse effects*; D008875:Middle Aged; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D013375:Substance Withdrawal Syndrome / Q000378:metabolism*
D004364:Pharmaceutical Preparations; D008750:Methyldopa