Evidence of a direct action of angiotensin II on neurones in the septum and in the medial preoptic area.
Angiotensin II (AII) was microiontophoretically applied on neurones located in the septum and the medial preoptic area (MPOA). All the septal neurones sensitive to AII (15/37) responded by an inhibition to the peptide application. Of 44 units tested in the MPOA 21 cells (48%) were sensitive to AII and responded either by an increase (11/21) or decrease (10/21) in their firing. The specificity of these responses were ascertained by simultaneous application of the antagonist Sar-Ile-Angiotensin II. These data suggest that Angiotensin II acts directly on neurones of the septum and medial preoptic area, structures implicated in the control of drinking behaviour.
D015059:1-Sarcosine-8-Isoleucine Angiotensin II / Q000494:pharmacology; D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D001921:Brain / Q000187:drug effects*; D005260:Female; D007031:Hypothalamus / Q000187:drug effects*; D008297:Male; D009474:Neurons / Q000187:drug effects*; D011301:Preoptic Area / Q000187:drug effects*; D051381:Rats
D000804:Angiotensin II; D015059:1-Sarcosine-8-Isoleucine Angiotensin II