Isoproterenol-induced enhancement of myocardial glucose-6-phosphate dehydrogenase.
Isoproterenol enhanced the activity of glucose-6-phosphate dehydrogenase and the availability of 5-phosphoribosyl-1-pyrophosphate in the rat myocardium, which indicates an increased flow through the hexose monophosphate shunt. The stimulatory effect of isoproterenol on cardiac glucose-6-phosphate dehydrogenase activity, could be prevented by beta-receptor blockade with atenolol, but not by the calcium-antagonistic compound D 600.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000032:analysis*; D006321:Heart / Q000187:drug effects*; D007545:Isoproterenol / Q000494:pharmacology*; D009206:Myocardium / Q000201:enzymology* / Q000378:metabolism; D051381:Rats
D000227:Adenine Nucleotides; D005954:Glucosephosphate Dehydrogenase; D007545:Isoproterenol