Cortical facilitatory effect of mefenamic acid.
Mefenamic acid intravenously injected or locally applied upon the cerebral cortex increases the amplitude of the evoked responses recorded in the somatosensory S1 cortex. This facilitatory effect supports previous EEG studies showing that this drug also has central actions. In light of the present result it is suggested that the central action induced by mefenamic acid occurs at the cortical level.
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects*; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D006168:Guinea Pigs; D008528:Mefenamic Acid / Q000494:pharmacology*; D012119:Respiration / Q000187:drug effects; D013003:Somatosensory Cortex / Q000187:drug effects
D008528:Mefenamic Acid