A procedure for testing potential inhibitors of human chorionic gonadotrophin activity in vivo.
A procedure is described for testing potential inhibitors of hCG activity in vivo, based on a hormone-responsive alkaline phosphatase in the ovaries of young mice. Standard injections of an antiserum inhibited the response to a subsequent injection of 2 i.u. hCG after an interval of up to 24 h.
D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001681:Biological Assay / Q000379:methods; D006063:Chorionic Gonadotropin / Q000037:antagonists & inhibitors* / Q000276:immunology; D004353:Drug Evaluation, Preclinical / Q000379:methods; D005260:Female; D007106:Immune Sera; D051379:Mice; D010053:Ovary / Q000201:enzymology; D012741:Sexual Maturation
D006063:Chorionic Gonadotropin; D007106:Immune Sera; D000469:Alkaline Phosphatase