[Evidence for the secretion of gastrin into the duodenal lumen of man].
In six healthy male subjects the duodenum was perfused with phosphate buffer and peptone respectively via a double balloon tube. During peptone perfusion secretion of gastrin into the duodenal lumen and serum gastrin rose simultaneously and significantly compared with buffer control. There was a significant but delayed increase of gastric acid secretion. 60 % of the gastrinlike immunoreactivity in duodenal perfusates corresponded to gastrin 1-34 and 40 % to gastrin 1-17 when separated by starch gel electrophoresis and gel filtration.
D004386:Duodenum / Q000187:drug effects*; D005744:Gastric Acid / Q000378:metabolism; D005755:Gastrins / Q000097:blood / Q000378:metabolism*; D006801:Humans; D008297:Male; D010461:Peptones / Q000494:pharmacology*; D010477:Perfusion; D010710:Phosphates / Q000494:pharmacology*
D005755:Gastrins; D010461:Peptones; D010710:Phosphates
Nachweis der Gastrinsekretion ins Lumen des menschlichen Duodenums.