[Experimental neuritis in the rat: absence of effect of metronidazole].
The aim of the present work was to verify whether metronidazole can induce experimental polyneuropathy in rats. The animals were divided into 7 groups and metronidazole was administered orally. Groups 1, 2 and 3 were treated for 32 days respectively with 100, 150, 200 mg/kg/day of metronidazole. The other 4 groups received a daily dose of 150 mg/kg and were sacrificed respectively on the 8th, 16th, 24th, 32nd day of metronidazole administration. The presence of polyneuropathy after treatment was evaluated by behavioural tests and by using an "in vitro" preparation of sciatic nerve-trunk of rat. Metronidazole showed no consistent neurotoxic effects.
D000818:Animals; D005071:Evoked Potentials / Q000187:drug effects; D008795:Metronidazole / Q000008:administration & dosage / Q000494:pharmacology*; D009431:Neural Conduction / Q000187:drug effects; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects*
D008795:Metronidazole
Nevriti sperimentali nel ratto: assenza di effetto del metronidazolo.