title: Synthesis and anti-inflammatory activity of certain new N,N'-oxamides.
abstract: Some new amides of substituted oxamic acid which embody different moieties of the anti-inflammatory drugs were prepared through two routes of synthesis. The physico-chemical properties as well as the anti-inflammatory activity of these compounds were determined. Preliminary pharmacological testing revealed the superiority of most of the screened compounds as anti-inflammatory agents with relatively low toxicity as compared with acetylsalicylic acid. Correlation between structure and biological activity was suggested.
mesh_terms: D000596:Amino Acids / Q000138:chemical synthesis*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000633:toxicity; D001241:Aspirin / Q000494:pharmacology; D005260:Female; D006632:Histamine; D007249:Inflammation / Q000139:chemically induced; D007928:Lethal Dose 50; D008297:Male; D010072:Oxamic Acid / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D014992:Xylenes
chemical_list: D000596:Amino Acids; D000893:Anti-Inflammatory Agents; D014992:Xylenes; D006632:Histamine; D010072:Oxamic Acid; D001241:Aspirin