title: [Aerosol method of using interferon inducers].
abstract: A method for aerosol use of interferon inducer in laboratory animals employing an ultrasonic aerosol generator is described. Formules and a table of calculations of an inhalation dose of interferon inducer in solution when atomized in a chamber, as well as in the use of individual masks for monkeys are presented. The aerosol administration of interferon inducer (replicative from RNA of phage f2) was found to be effective in inducing interferon production in mice and monkeys. Prophylactic administration of the inducer 4 and 24 hours before inoculation protected from 50% to 75% of mice against a fatal influenza infection.
mesh_terms: D000336:Aerosols; D000818:Animals; D001435:Bacteriophages; D002522:Chlorocebus aethiops; D004306:Dose-Response Relationship, Immunologic; D007369:Interferon Inducers / Q000008:administration & dosage*; D051379:Mice; D009976:Orthomyxoviridae Infections / Q000276:immunology; D012330:RNA, Double-Stranded / Q000008:administration & dosage; D012367:RNA, Viral / Q000008:administration & dosage; D013997:Time Factors
chemical_list: D000336:Aerosols; D007369:Interferon Inducers; D012330:RNA, Double-Stranded; D012367:RNA, Viral
vernacular_title: Aérozol'nyĭ sposob primeneniia induktorov interferona.