title: Environmental temperature, a factor modifying the acute toxicity of organic solvents, heavy metals, and agricultural chemicals.
abstract: 1500 male mice, previously acclimatized to 8,22 or 38 degrees C, were used to determine the median lethal doses of organic solvents, heavy metals and agricultural chemicals by the Up-and-Down method via several routes of administration. Acute toxicity of benzene, trichloroethylene, mercuric chloride, cadmium chloride, fratol, methylparathion and dieldrin increased markedly at a low temperature of 8 degrees C, as well as at a high temperature of 38 degrees C. Acute toxicity of toluene, copper sulfate and chromium trioxide was only enhanced at a high temperature of 38 degrees C.
mesh_terms: D000818:Animals; D001554:Benzene / Q000633:toxicity; D002104:Cadmium / Q000633:toxicity; D003300:Copper / Q000633:toxicity; D004026:Dieldrin / Q000633:toxicity; D004785:Environmental Pollutants / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D008628:Mercury / Q000633:toxicity; D008670:Metals / Q000633:toxicity*; D008743:Methyl Parathion / Q000633:toxicity; D051379:Mice; D012997:Solvents / Q000633:toxicity*; D013696:Temperature; D014050:Toluene / Q000633:toxicity
chemical_list: D004785:Environmental Pollutants; D007306:Insecticides; D008670:Metals; D012997:Solvents; D002104:Cadmium; D014050:Toluene; D008743:Methyl Parathion; D003300:Copper; D008628:Mercury; D004026:Dieldrin; D001554:Benzene