title: Pharmacokinetics of 2-(p-methylallylaminophenyl) propionic acid, alminoprofene, in man after single and multiple oral doses.
abstract: 2-(p-methylallylaminophenyl) propionic acid, alminoprofene (INN), a new antalgic drug, was administered orally to men as a single (300 mg) and multiple doses (300 mg three times daily). Plasma and urine concentrations of alminoprofene were determined by gas-liquid chromatography. After the single oral dose, the peak plasma level (36.2 to 41.5 mg/l) was reached within 0.5 -1.5 h. the biological half-life ranged from 2.5 to 3.2 h. During chronic administration of alminoprofene, steady-state equilibrium was established within 24 h. The urinary excretion of alminoprofene as unchanged product and as glucuronide was very important.
mesh_terms: D000284:Administration, Oral; D000700:Analgesics / Q000008:administration & dosage / Q000378:metabolism*; D006801:Humans; D007700:Kinetics; D011422:Propionates / Q000008:administration & dosage / Q000378:metabolism*
chemical_list: D000700:Analgesics; D011422:Propionates; C027953:alminoprofen