title: Tissue and fluid concentrations of cefadroxil monohydrate.
abstract: In summary, there are several tissues and fluids in which the penetration of cefadroxil appears to be superior to that of other antibiotics, including other cephalosporins. A possible explanation for this relates to the characteristic solubility of cefadroxil in both aqueous and lipid solvents. A study comparing IV, IM and PO administration of cefadroxil appears to support this thesis. Clinically, based on work which shows that patients who had higher concentrations of antibiotic in sputum made a faster recovery, cefadroxil may have an advantage since sputum is one of the fluids in which the drug appears to have superior and earlier penetration. In addition, in comparison with cephalexin, penetration of skin-blister fluid by cefadroxil was superior, suggesting an advantage in treating disorders of the skin and skin structures, such as impetigo. The possibility of different dosage requirements for male and female patients, based on the difference in the availability of lipid deposit sites, cannot be considered clinically significant at this time.
mesh_terms: D001768:Blister / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism; D001842:Bone and Bones / Q000378:metabolism; D002434:Cefadroxil; D002506:Cephalexin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000378:metabolism; D006801:Humans; D008168:Lung / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D011467:Prostate / Q000378:metabolism; D012995:Solubility; D013183:Sputum / Q000378:metabolism
chemical_list: D002434:Cefadroxil; D002506:Cephalexin