Evidence for the secretion of gastrin into human gastric juice.
Provided the intragastric pH is greater than 6 and the collected gastric juice is boiled and neutralised immediately, considerable amounts of gastrin-like immunoreactivity can be found in human gastric juice. Characterisation according to size and charge reveals that nearly all the gastrin-like immunoreactivity is similar to gastrin 1-17. Direct stimulation of the G-cells with protein solution is followed by a significant and simultaneous increase of acid secretion, serum gastrin, and gastrin output into the lumen of the stomach in control subjects and patients with duodenal ulcer.
D002850:Chromatography, Gel; D004381:Duodenal Ulcer / Q000503:physiopathology; D004592:Electrophoresis, Starch Gel; D005750:Gastric Juice / Q000032:analysis; D005755:Gastrins / Q000032:analysis / Q000378:metabolism*; D006801:Humans; D011863:Radioimmunoassay
D005755:Gastrins