Impaired resistance to bacterial infection after tumor implant is traced to lactic dehydrogenase virus.
A BALB/c mouse-passaged methylcholanthrene-induced fibrosarcoma tumor caused severe impairment of resistance to systemic listeriosis. Depressed resistance expressed immediately after tumor implantation was traced to inadvertent association of tumor with lactic dehydrogenase virus. Tumor cured of virus was totally inactive.
D000818:Animals; D005354:Fibrosarcoma / Q000382:microbiology*; D007108:Immune Tolerance; D007772:Lactate dehydrogenase-elevating virus / Q000502:physiology*; D008088:Listeriosis / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009368:Neoplasm Transplantation; D012513:Sarcoma, Experimental / Q000382:microbiology*; D014182:Transplantation, Autologous