Plasma antithrombin III activity in normal pregnancy.
The incidence of thromboembolic phenomena increases in pregnancy. Antithrombin III has been implicated as a possible etiologic factor for the increase of thromboembolic phenomena in women receiving exogenous estrogens. In a study of normal obstetric, postpartum, and oral contraceptive patients, no significant change in antithrombin III activity could be detected in a plasma-based assay within and among these groups. It is hypothesized that a decrease in antithrombin III activity is not a cause of increased thromboembolic phenomena during normal pregnancy and oral contraceptive use.
D000990:Antithrombin III / Q000378:metabolism*; D003280:Contraceptives, Oral, Synthetic / Q000494:pharmacology; D005260:Female; D006801:Humans; D049590:Postpartum Period; D011247:Pregnancy
D003280:Contraceptives, Oral, Synthetic; D000990:Antithrombin III