Cholinergic components in the gastrin pathway of gastric acid stimulation.
In the isolated whole stomach of the mouse, cimetidine and atropine appear to be specific antagonists of histamine- and acetylcholine-induced stimulation of parietal cells. Interactions were demonstrated between cimetidine and gastrin, atropine and gastrin, respectively. In addition to a histaminergic pathway of gastrin stimulation, a cholinergic part, probably postganglionic, can be taken into consideration.
D000109:Acetylcholine / Q000378:metabolism; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002927:Cimetidine / Q000494:pharmacology; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000494:pharmacology*; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006632:Histamine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D051379:Mice; D010275:Parasympathetic Nervous System / Q000502:physiology*
D005755:Gastrins; D006584:Hexamethonium Compounds; D001285:Atropine; D002927:Cimetidine; D006632:Histamine; D000109:Acetylcholine