title: [Ototoxicity of locally applied amino-glycosides (author's transl)].
abstract: Medical literature contains numerous references to the ototoxic effects of amino-glycosides if locally applied. In the present study patients who had fallen ill with otitis externa with concomitant myringitis, whose eardrum however, was intact, were treated with Neomycin and Polymyxin B containing ear-drops (Otosporin) and supervised audiometrically. There were no references to any ototoxic damage to the inner ear as a consequence of the treatment. Theoretical considerations and reports in the literature on the subject give advice to caution in the case of eardrum perforations and surgical caverns.
mesh_terms: D000617:Aminoglycosides / Q000009:adverse effects*; D007758:Ear, Inner / Q000187:drug effects*; D006320:Hearing Tests; D006801:Humans; D009355:Neomycin / Q000627:therapeutic use; D010032:Otitis Externa / Q000188:drug therapy
chemical_list: D000617:Aminoglycosides; D009355:Neomycin
vernacular_title: Uber due Ototoxizität von Aminoglykosiden bei lokaler Anwendung.