title: [CK concentration--an indicator of infarct size? (author's transl)].
abstract: The postulated relation between the course of the enzyme CK and infarct size is submitted to a mathematical methodological critique. On the basis of the production and the degradation of CK, permissible solutions could be found using simplified hypotheses. Unfortunately the coefficient permitting the solving function cannot be calculated unequivocally from the measured CK course. Only if the CK liberation and elimination are hypothesized to follow an idential diffusion process, a simplified permissible solving function can be identified from measured CK data. The total amount of liberation CK can be calculated from the coefficient of the simplified solving function thus derived. A comparison with the originally used, general and not reversibly unequivocal solving function shows that the simplification unevitably produces considerable differences in the calculation of the total liberated amount of CK. Only statistical averages of many patients may be taken to be adequately representative. The mathematical methodological investigations demonstrate that measured CK values may be used for individual statements only with considerable caution.
mesh_terms: D003402:Creatine Kinase / Q000097:blood* / Q000378:metabolism; D006801:Humans; D008433:Mathematics; D008954:Models, Biological; D009203:Myocardial Infarction / Q000201:enzymology* / Q000473:pathology
chemical_list: D003402:Creatine Kinase
vernacular_title: Die CK-Konzentration--Ein Mass für die Infarktgrösse?