Pharmacological properties of two analogues of angiotensin II containing carboranylalanine (Car).
The pharmacological properties of two angiotensin II analogues containing carboranylalanine (Car) are reported. Sar-Arg-Val-Tyr-Val-His-Pro-Car is a weak partial agonist showing 15% intrinsic activity and a very long lasting action, specific for the angiotensin II receptor of the rabbit aorta. Sar-Arg-Val-Car-Val-His-Pro-Phe is inactive on the angiotensin II receptor. These properties are discussed in view of recent findings on the action of angiotensin II on its smooth muscle receptor.
D000804:Angiotensin II / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D011817:Rabbits; D011945:Receptors, Angiotensin / Q000187:drug effects
D011945:Receptors, Angiotensin; C027053:angiotensin II, Sar(1)-Car(4)-; C027052:angiotensin II, Sar(1)-Car(8)-; D000804:Angiotensin II