title: Cadmium and the reticuloendothelial system (RES). A specific defect in blood clearance of soluble aggregates of IgG by the liver in mice given cadmium.
abstract: The ability of the reticuloendothelial system (RES) to bind and catabolize soluble stable heat aggregates of 125I-IgG (A-IgG) was studied in mice given oral cadmium. Cadmium caused a delay in the circulation clearance of A-IgG in intact animals. The defect was due to impaired liver uptake of A-IgG and correlated with increased liver cadmium. Subsequent catabolism of bound A-IgG by liver slices was not affected. The defect was specific in that clearance of aggregated human serum albumin and colloidal carbon was normal in cadmium mice; this suggests that cadmium may affect either Fc or complement receptors of Kupffer cells in liver.
mesh_terms: D000818:Animals; D002104:Cadmium / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000378:metabolism*; D066298:In Vitro Techniques; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008264:Macrophages / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012157:Mononuclear Phagocyte System / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism; D013997:Time Factors
chemical_list: D007074:Immunoglobulin G; D012709:Serum Albumin; D002104:Cadmium