Effects of bicuculline and chlordiazepoxide on locomotor activity and avoidance performance in rats.
Bicuculline, at a dose of 1 mg/kg which, per se, failed to change locomotor activity in rats, counteracts the facilitating effect induced by chlordiazepoxide (10 mg/kg). Conversely, bicuculline (1 mg/kg) does not modify the decrease of motor activity and the disruption of avoidance performance induced by this benzodiazepine derivative (20 mg/kg).
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D001640:Bicuculline / Q000494:pharmacology*; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004347:Drug Interactions; D008124:Locomotion / Q000187:drug effects*; D008297:Male; D051381:Rats
D002707:Chlordiazepoxide; D001640:Bicuculline