Pharmacokinetics of vinyl chloride in the Rhesus monkey.
The metabolic elimination of vinyl chloride in Rhesus monkeys is a dose-dependent, satruable process, as in rats. Below 200-300 ppm of vinyl chloride (VC) in atmosphere, elimination obeys a first-order law; the clearance rate is much closer to that found in man than the values for rats, mice and gerbils. The maximal velocity of metabolic elimination of VC at high concentrations in Rhesus monkeys is only about half that of rats when related to kg body weight. It s suggested that Rhesus monkeys mimic the quantitative aspects of VC metabolism better than rats or mice.
D000818:Animals; D001274:Atmospheric Pressure; D005849:Gerbillinae; D006801:Humans; D008251:Macaca / Q000378:metabolism*; D008253:Macaca mulatta / Q000378:metabolism*; D008657:Metabolic Clearance Rate; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D014752:Vinyl Chloride / Q000378:metabolism*; D014753:Vinyl Compounds / Q000378:metabolism*
D014753:Vinyl Compounds; D014752:Vinyl Chloride