Perioral leukoderma simulating vitiligo from use of a toothpaste containing cinnamic aldehyde.
Perioral leukoderma simulating vitiligo developed in a 25-year-old woman. A patch test to cinnamic aldehyde was positive; depigmentation was observed at the patch test site three months after initial application. No changes in pigmentation occurred from a concomitant allergic patch test reaction to neomycin sulfate; only hyperpigmentation occurred at the site of an irritant patch test reaction to nonanoic acid. A toothpaste containing cinnamic aldehyde was implicated; perioral hypopigmentation resolved when a toothpaste without cinnamic aldehyde was substituted. A repeated patch test to cinnamic aldehyde again showed depigmentation at the patch test site three months after application.
D000171:Acrolein / Q000009:adverse effects* / Q000031:analogs & derivatives; D000328:Adult; D000447:Aldehydes / Q000009:adverse effects*; D003802:Dentifrices / Q000009:adverse effects*; D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000139:chemically induced*; D005260:Female; D006801:Humans; D010328:Patch Tests; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000175:diagnosis; D014100:Toothpastes / Q000009:adverse effects*; D014820:Vitiligo / Q000175:diagnosis*
D000447:Aldehydes; D003802:Dentifrices; D014100:Toothpastes; D000171:Acrolein; C012843:cinnamaldehyde