Synthesis, absorption, and toxicity of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator.
A synthesis of N1,N8-bis(2,3-dihydroxybenzoyl)spermidine, a potent iron chelator, is developed employing N4-benzylspermidine as the starting material. Both the toxicity and the absorption properties of this compound are evaluated, further supporting its potential as a clinical iron chelator.
D000818:Animals; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D007502:Iron Chelating Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000633:toxicity; D051379:Mice; D013095:Spermidine / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000378:metabolism / Q000633:toxicity
D007502:Iron Chelating Agents; C026327:N(1),N(8)-bis(2,3-dihydroxybenzoyl)spermidine; D013095:Spermidine