Thyroid function in pediatric patients after neck irradiation for Hodgkin disease.
Thyroid function was evaluated in a consecutively treated group of children and adolescents with Hodgkin disease who received incidental radiation to the thyroid gland. Ten of 27 (36.7%) were found to have elevated concentrations of thyroid-stimulating hormone (TSH). Two groups of patients had an increased incidence of thyroid dysfunction - those who had not had a pretreatment lymphangiogram and those who were less than 13 years of age at the time of neck irradiation. The estimated percentage of patients who did not have a pretreatment lymphangiogram who will develop TSH elevation was 67.7% and of patients who were 13 years of age or less when irradiated, 64.8%. Thyroid dysfunction developed in 6/7 patients who had both of these risk factors present.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D006689:Hodgkin Disease / Q000150:complications / Q000000981:diagnostic imaging / Q000532:radiotherapy*; D006801:Humans; D007037:Hypothyroidism / Q000209:etiology*; D008220:Lymphography / Q000009:adverse effects; D009333:Neck / Q000528:radiation effects; D011832:Radiation Injuries / Q000209:etiology; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D013961:Thyroid Gland / Q000528:radiation effects*; D013972:Thyrotropin / Q000097:blood
D013972:Thyrotropin