[Apoprotein A-1 in high-density lipoprotein subfractions and lecithin-cholesterol-acyltransferase activity in hyperalphacholesterinemia].
Content of apolipoprotein (apo A-I) was studied in subfractions of high density lipoproteins (HDL) using quantitative "rocket" immunoelectrophoresis in two groups of men with the level of LPHD cholesterol within 70 mg/dl (27 patients) and above 70 mg/dl (15 patients). An increase in content of cholesterol from HDL2 subfraction and activation of lecithine-cholesterol acyltransferase in hyper-alpha-cholesterolemia (hyper-alpha-lipoproteinemia) were mainly due to elevation in both absolute amount of apo A-I containing in HDL2 of blood plasma and in relative part of apo A-I in HDL2 of blood plasma and in relative part of apo A-I in HDL2. But contrary to the observation, content of apo A-I from HDL3 subfraction was decreased in the impairment. In aggrement with the modern hypothesis on the antiatherogenic nature of hyper-alpha-lipoproteinemia, the impairment is related to intensification of the cholesterol-acceptor function of HDL due to the activating effect of apolipoprotein A-I (content of which is increased in HDL2) on lecithine-cholesterol acyltransferase in vivo.
D000328:Adult; D001059:Apoproteins / Q000097:blood*; D002784:Cholesterol / Q000097:blood; D004789:Enzyme Activation; D006801:Humans; D006937:Hypercholesterolemia / Q000097:blood*; D008075:Lipoproteins, HDL / Q000097:blood*; D008297:Male; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*; D014280:Triglycerides / Q000097:blood
D001059:Apoproteins; D008075:Lipoproteins, HDL; D014280:Triglycerides; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
Apoprotein A-1 v podfraktsiiakh lipoproteidov vysokoĭ plotnosti i aktivnost' letsitin-kholesterin-atsiltransferazy pri giperal'fakholesterinemii.