title: [31P- and 1H-NMR-investigations about the interaction of ATP with Mg2+, Ca2+, and monoamines (author's transl)].
abstract: The interaction between aromatic amines and ATP is based upon an electrostatic attraction of the protonated amino groups to the negatively charged phosphate groups of ATP combined with a stacking association between the ring systems. The complexes formed are relatively weak (association constants 4--48 M-1), shortlived (life time smaller than 0.02 s), and mainly 1:1 in stoichiometry preferring the terminal phosphate of ATP as the site of association. The divalent metal ions Mg2+ and Ca2+ bond stronger than the amines (association constants 1500 and 100 M-1, resp.) prefer the beta-phosphate group changing thereby the geometry of the ATP phosphate chain. Thus, they reduce the amine-ATP association in ternary mixtures.
mesh_terms: D000255:Adenosine Triphosphate; D000588:Amines; D002118:Calcium; D055598:Chemical Phenomena; D002621:Chemistry; D004298:Dopamine; D007700:Kinetics; D008274:Magnesium; D009682:Magnetic Resonance Spectroscopy
chemical_list: D000588:Amines; D000255:Adenosine Triphosphate; D008274:Magnesium; D002118:Calcium; D004298:Dopamine
vernacular_title: 31P- und 1H-NMR-Untersuchungen über die Wechselwirkung von ATP mit Mg2+, Ca2+ und Monoaminen.