Tumorigenic effect of topical mechlorethamine, BCNU and CCNU in mice.
Mice were painted with mechlorethamine (HN2), carmustine (BCNU) and lomustine (CCNU) for up to 33 weeks. HN2 was a potent carcinogen, producing squamous cell carcinomas in 9 of 33 mice in 1 series. BCNU was a weak carcinogen. CCNU produced no tumors in 1 series.
D000818:Animals; D002273:Carcinogens; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced; D002330:Carmustine / Q000633:toxicity*; D008130:Lomustine / Q000633:toxicity*; D008466:Mechlorethamine / Q000633:toxicity*; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009607:Nitrosourea Compounds / Q000633:toxicity*; D010212:Papilloma / Q000139:chemically induced; D012878:Skin Neoplasms / Q000139:chemically induced*
D002273:Carcinogens; D009607:Nitrosourea Compounds; D008466:Mechlorethamine; D008130:Lomustine; D002330:Carmustine