Decreased ulcerogenic effect of indomethacin in the rat when given in association with diflunisal.
A combination of indomethacin and diflunisal, a new salicylic acid derivative, when given to rats, gave a greater reduction in the size of permanganate induced granulomas and less gastric irritation, than either drug given alone.
D000818:Animals; D004061:Diflunisal / Q000008:administration & dosage / Q000633:toxicity*; D004359:Drug Therapy, Combination; D006099:Granuloma / Q000188:drug therapy; D007213:Indomethacin / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D051381:Rats; D012459:Salicylates / Q000633:toxicity*; D013272:Stomach Diseases / Q000188:drug therapy; D013276:Stomach Ulcer / Q000139:chemically induced*
D012459:Salicylates; D004061:Diflunisal; D007213:Indomethacin