Effect of colchicine on polymorphonuclear leucocyte chemotaxis in human volunteers.
1 The effect of colchicine on polymorphonuclear leucocyte chemotaxis was assessed in eight healthy volunteers. Four of them received 1.0 mg colchicine and the other four received placebo daily for 8 successive days. 2 Chemotaxis decreased significantly within 24 h of the ingestion of colchicine; the values remained low throughout the 8 days of treatment and returned to normal within 48 h of cessation of medication. 3 There were no significant changes in the placebo treated subjects.
D000328:Adult; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D003078:Colchicine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D009504:Neutrophils / Q000187:drug effects; D010919:Placebos; D013997:Time Factors
D010919:Placebos; D003078:Colchicine