Alphaxalone infusion during cardiopulmonary bypass.
A continuous infusion of alphaxalone (as Althesin) was used to maintain anaesthesia for patients undergoing open heart surgery. Plasma levels of the drug were measured at intervals during the procedure. It was found that alphaxalone was adequatley removed from the circulation, despite a period of cardiopulmonary bypass and hypothermia, and provided suitable anaesthesia for this type of surgery.
D000328:Adult; D000368:Aged; D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage / Q000097:blood; D000771:Anesthesia, Intravenous; D002315:Cardiopulmonary Bypass; D006801:Humans; D007036:Hypothermia, Induced; D007263:Infusions, Parenteral; D008875:Middle Aged; D013997:Time Factors
D000530:Alfaxalone Alfadolone Mixture