Structural characteristics in regional versus global ischemia.
In regional ischemia the tissue is damaged by the lack of oxygen, by mechanical stress, and by the consequences of a low-flow condition caused by collateral flow. In global ischemia the lack of oxygen is the only cause of cellular injury. Although mitochondrial and nuclear changes are similar, it is evident that regional and global ischemia are distinctly different situations from a pathophysiological and structural point of view. Results from either model of ischemia should be considered separately and should not be transferred from one situation to the other.
D000818:Animals; D002467:Cell Nucleus / Q000473:pathology / Q000648:ultrastructure; D003327:Coronary Disease / Q000473:pathology* / Q000503:physiopathology; D004285:Dogs; D000860:Hypoxia / Q000503:physiopathology; D008854:Microscopy, Electron; D008929:Mitochondria, Heart / Q000473:pathology / Q000648:ultrastructure; D009206:Myocardium / Q000473:pathology / Q000648:ultrastructure*