[Mechanism of EA-rosette formation blockade by antisera against cell surface antigens].
The effect of different antisera to cell surface antigens on EA-rosette formation was investigated. Anti-immunoglobulin serum causes almost total blockade of EA-rosette formation by murine spleen and bone marrow cells. Rabbit anti-mouse brain-associated theta-antigen immunoglobulin has the same effect on EA-rosette formation by murine splenocytes but it has a slight action on EA-rosette formation by rat splenocytes. The mixing of rat splenocytes and autologous or mouse thymocytes increased the blocking influence of anti-BA theta-immunoglobulin. These findings indicate a requirement for specific antigen in the test-system for blockade of EA-rosette formation. This antigen is not necessarily expressed on the surface of Fc-receptor-bearing cells.
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D004912:Erythrocytes / Q000276:immunology; D006824:Hybridization, Genetic; D007106:Immune Sera / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011817:Rabbits / Q000276:immunology; D051381:Rats; D011961:Receptors, Fc / Q000276:immunology*; D012397:Rosette Formation; D012756:Sheep / Q000276:immunology
D000954:Antigens, Surface; D007106:Immune Sera; D011961:Receptors, Fc
Mekhanizm blockady EA-rozetkoobrazovaniia antisyvorotkami protiv antigenov kletochnoĭ poverkhnosti.