Biochemical changes in humans upon exposure to sulfuric acid aerosol and exercise.
This study evaluated the effect of a single exposure to sulfuric acid aerosol on six human biochemical blood parameters. A total of 18 human subjects were exposed to ambient air for 4 hr on the first day of exposure and to 100 microgram/m3 (0.033 microM) sulfuric acid aerosol (0.5 micrometer mean mass diameter) for 4 hr on the second day. A total of 17 human subjects were exposed for 4 hr to ambient air on both exposure days. On each exposure day, at 30 min and 90 min after exposure was initiated, all subjects engaged in a 15-min exercise period (walking 4 mph on a treadmill inclined at 10 degrees). Six biochemical blood parameters were measured before and after exposure: glutathione, lysozyme, glutathione reductase, serum glutamic oxaloacetic acid transaminase, serum vitamin E, and 2, 3-diphosphoglyceric acid. The results indicate no significant effect of one 4-hr exposure of humns to 100 microgram/m3 sulfuric acid aerosol. One significant post-exposure effect did occur--an increase in glutathione reductase--for both the control and acid-exposed group. It is concluded that at the levels studied, sulfuric acid aerosol is neutralized in the upper airways; consequently, no cellular damage is measurable.
D000328:Adult; D000336:Aerosols; D004163:Diphosphoglyceric Acids / Q000097:blood*; D004798:Enzymes / Q000097:blood*; D005978:Glutathione / Q000097:blood*; D006801:Humans; D008297:Male; D005082:Physical Exertion; D013464:Sulfuric Acids / Q000633:toxicity*; D014810:Vitamin E / Q000097:blood*
D000336:Aerosols; D004163:Diphosphoglyceric Acids; D004798:Enzymes; D013464:Sulfuric Acids; D014810:Vitamin E; D005978:Glutathione