[Biochemical characteristics of the individual sensitivity of human stomach cancers to 5-fluorouracil].
Two hundred radical operations on gastric tumor patients were performed in the Lvov oncological centre during 1974-1978. As a result of biochemical studies of gastric tumors some essential alterations were established in the 5FU-6-3H incorporation into the acid soluble fraction and in the activity of alkaline phosphatase in 5FU sensitive and resistant tumors. Additional chemotherapy with 5FU was carried out only for patients with tumors sensitive to the drug, due to it the 5-year survival rate in this group of patients has significantly raised.
D000328:Adult; D002478:Cells, Cultured; D004341:Drug Evaluation; D004351:Drug Resistance; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use*; D005753:Gastric Mucosa / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy / Q000378:metabolism* / Q000401:mortality
D005472:Fluorouracil
Biokhimicheskie osobennosti individual'noĭ chuvstvitel'nosti raka zheludka cheloveka k 5-ftoruratsilu.