The diuretic effect of secretin in man.
Six young healthy male students were studied with an intravenous infusion of 50 ml/h saline for three 2 h periods. In the second 2 h period pure natural secretin was added to the saline infusion in a dose of 2 CU/kg . h. Urine was collected separately in the three 2 h periods, and blood was drawn every 1 h. Urinary water, sodium, potassium, chloride, calcium, creatinine and solute excretion increased significantly during the 2-h secretin period. The clearance of sodium, potassium, chloride, calcium and solutes as a percentage of glomerular filtration rate (creatinine clearance) increased significantly, whereas tubular reabsorption of sodium as a percentage of filtrated sodium decrased significantly during secretin infusion. Even though plasma secretin remained elevated in the first half of the last 2 h control period, no diuretic effect was noted in this period. It would appear therefore that the diuretic effect of secretin most likely is a pharmagological effect only.
D001834:Body Water / Q000032:analysis; D003404:Creatinine / Q000652:urine; D004231:Diuresis / Q000187:drug effects*; D004573:Electrolytes / Q000378:metabolism / Q000652:urine; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000187:drug effects; D012633:Secretin / Q000097:blood / Q000494:pharmacology*
D004573:Electrolytes; D012633:Secretin; D003404:Creatinine