[Effect of miskleron (clofibrate) on dimethylhydrazine induction of intestinal tumors in rats].
Intestinal tumors were induced in male rats by dimethylhydrazine (14 mg/kg body weight subcutaneously once a week during 20 weeks). Part of animals received clofibrat per os in a dose of 25 mg a day 5 times a week. Clofibrat did not influence the frequency of the development of intestinal tumors but significantly decreased the number of medium-size and large tumors. The possible mechanisms of clofibrat action as well as the use of clofibrat and some related agents in oncology are discussed.
D000818:Animals; D002784:Cholesterol / Q000097:blood; D002994:Clofibrate / Q000627:therapeutic use*; D004127:Dimethylhydrazines / Q000037:antagonists & inhibitors*; D007414:Intestinal Neoplasms / Q000139:chemically induced* / Q000517:prevention & control; D007420:Intestine, Large; D007421:Intestine, Small; D008074:Lipoproteins / Q000097:blood; D008297:Male; D008763:Methylhydrazines / Q000037:antagonists & inhibitors*; D009374:Neoplasms, Experimental; D051381:Rats; D014280:Triglycerides / Q000097:blood
D004127:Dimethylhydrazines; D008074:Lipoproteins; D008763:Methylhydrazines; D014280:Triglycerides; D002784:Cholesterol; D002994:Clofibrate
Vliianie misklerona (klofibrata) na induktsiiu dimetilgidrazinom opukholeĭ kishechnika u krys.