title: A service program of antituberculosis chemotherapy with five drugs for four months in the treatment of drug addicts and prisoners with pulmonary tuberculosis in Hong Kong. Hong Kong Chest Service/British Medical Research Council.
abstract: The results are reported of a service in Hong Kong of intensive antituberculosis chemotherapy with 5 drugs given daily for 4 months, or until discharge from hospital or release from prison if earlier, in the treatment of male Chinese drug addicts and prisoners who had pulmonary tuberculosis positive for acid-fast bacilli on microscopic examination of the sputum. Of 69 patients who received 4 months of chemotherapy, all those with sputum cultures negative for M. tuberculois initially, and more than 80% of those with positive cultures, 41% of whom had strains resistant to isoniazid, streptomycin, or both drugs, achieved quiescent disease, which was maintained for a year of follow-up. Some of the patients who received less than 4 months of chemotherapy also reponded well. Despite the 5 drugs, the frequency of adverse reactions to the regimen was low.
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004352:Drug Resistance, Microbial; D004977:Ethambutol / Q000627:therapeutic use; D006556:Heroin Dependence / Q000150:complications; D006723:Hong Kong; D006801:Humans; D007538:Isoniazid / Q000627:therapeutic use; D008297:Male; D009293:Opioid-Related Disorders / Q000150:complications; D009892:Opium; D011329:Prisoners; D011718:Pyrazinamide / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use; D013307:Streptomycin / Q000627:therapeutic use; D014376:Tuberculosis / Q000188:drug therapy; D014397:Tuberculosis, Pulmonary / Q000150:complications / Q000188:drug therapy*
chemical_list: D000995:Antitubercular Agents; D011718:Pyrazinamide; D009892:Opium; D004977:Ethambutol; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin