Depletion of C2 and C4 in sera from hamsters bearing herpes simplex type 2-induced tumors.
Total hemolytic complement activity (CH50) was compared in sera from normal and tumor-bearing hamsters. CH50 ranged from 160-216 in normal animals and from 82 to 152 in tumor-bearing animals. Preliminary screening assays indicated that of 9 complement components assayed, only C2 and C4 showed differences in titer in both normal and tumor-bearer sera. In an expanded study, examination of sera from 12 normal and 14 tumor-bearing hamsters showed that the mean C4 and C2 levels were approximately 88 and 70% below those seen in normal sera, respectively.
D000818:Animals; D000951:Antigens, Neoplasm; D003175:Complement C2 / Q000172:deficiency; D003181:Complement C4 / Q000172:deficiency; D003165:Complement System Proteins; D006224:Cricetinae; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000276:immunology*
D000951:Antigens, Neoplasm; D003175:Complement C2; D003181:Complement C4; D003165:Complement System Proteins