Acute exposure of laboratory mice to manganese oxide.
An acute inhalation exposure of laboratory mice to respirable Mn3O4 aerosols is described. The generation system consisted of a Wright dust generator which produced 1.40 micrometer aerosols. A non-linear loss of deposited manganese from mouse lungs over the inital 24-hour post-exposure period was observed. Systemic distribution of the manganese was observed in various tissues following exposure.
D000393:Air Pollutants / Q000032:analysis*; D000395:Air Pollutants, Occupational / Q000032:analysis*; D000818:Animals; D007668:Kidney / Q000032:analysis; D008099:Liver / Q000032:analysis; D008168:Lung / Q000032:analysis / Q000187:drug effects; D008345:Manganese / Q000032:analysis; D020149:Manganese Poisoning; D008452:Maximum Allowable Concentration; D051379:Mice; D010087:Oxides / Q000032:analysis; D013154:Spleen / Q000032:analysis; D014018:Tissue Distribution
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D010087:Oxides; D008345:Manganese