Specific 3H-imipramine binding in human platelets. Influence of age and sex.
Human platelets have been shown to possess high-affinity binding sites for 3H-imipramine. These binding sites have a similar affinity and drug specificity to those already described in rat brain. The platelets from healthy volunteers show no difference in 3H-imipramine binding between the sexes but there is a decrease in maximal 3H-imipramine binding with increasing age of the donor.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D001665:Binding Sites; D001792:Blood Platelets / Q000378:metabolism*; D005260:Female; D006801:Humans; D007099:Imipramine / Q000097:blood*; D007700:Kinetics; D008297:Male; D008566:Membranes / Q000378:metabolism; D008875:Middle Aged; D012737:Sex Factors
D007099:Imipramine