[Effect of hypoxia training on the resistance of animals to inhalation poisoning].
The rats trained to hypoxic hypoxia changed their resistance to the inhalation effect of dioxane and dichloroethane vapors. The training regimen (20-day continuous hypoxia at an altitude of 3,200 m and intermittent hypoxia for 6 hours a day amounting to 25 rises to an altitude of 5,000 m) influenced markedly the intoxication effect. Adaptation to hypoxia increased the alveolar-capillary surface of the lung parenchyma, thus enhancing a better entry of chemicals into the body. The posthypoxic pattern of the structural rearrangement of the pulmonary tissue was similar to that observed during moderate hyperoxia.
D000222:Adaptation, Physiological; D000818:Animals; D001808:Blood Vessels / Q000473:pathology; D004146:Dioxanes / Q000506:poisoning*; D004147:Dioxins / Q000506:poisoning*; D005025:Ethylene Dichlorides / Q000506:poisoning*; D006843:Hydrocarbons, Chlorinated / Q000506:poisoning*; D000860:Hypoxia / Q000150:complications* / Q000473:pathology; D008168:Lung / Q000098:blood supply / Q000473:pathology*; D011650:Pulmonary Alveoli / Q000473:pathology; D051381:Rats
D004146:Dioxanes; D004147:Dioxins; D005025:Ethylene Dichlorides; D006843:Hydrocarbons, Chlorinated
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