Influence of clonidine on experimental hypertension induced by cholinergic stimulation.
Hypertension may be induced by pharmacologic activation of central cholinergic receptors either indirectly, through the injection i.v. of physostigmine, or directly, through the injection of i.v. of arecholine in anesthetized rats. Activation of peripheral preganglionic cholinergic receptors with dimethylphenylpiperazinium iodide (DMPP) also produced a hypertensive response. Pretreatment with various doses of clonidine caused inhibition of the pressor response to central cholinergic stimulation but was without effect on the response to ganglionic cholinergic stimulation.
D000818:Animals; D001115:Arecoline / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects; D003000:Clonidine / Q000627:therapeutic use*; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D010525:Peripheral Nerves / Q000187:drug effects; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects
D011950:Receptors, Cholinergic; D001115:Arecoline; D004246:Dimethylphenylpiperazinium Iodide; D010830:Physostigmine; D003000:Clonidine