Post-swim grooming in mice inhibited by dopamine receptor antagonists and by cannabinoids.
After a period of swimming, mice engaged in vigorous grooming activity. This behaviour was inhibited in a dose dependent manner by dopamine receptor antagonists and by the cannabinoids, delta 9-tetrahydrocannabinol and cannabinol. Cannabidiol was inactive. It is suggested that the post-swin grooming behaviour involves a dopaminergic mechanism. The mechanism of action of the cannabinoids on this behaviour is unknown.
D000818:Animals; D002186:Cannabinoids / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006120:Grooming / Q000187:drug effects*; D051379:Mice; D011954:Receptors, Dopamine / Q000187:drug effects*; D013550:Swimming
D002186:Cannabinoids; D011954:Receptors, Dopamine