Effect of aspirin on spermatogenesis in mature and immature rats.
Aspirin administration for 30 days (5 mg/100 g body weight) caused a significant decrease in the weight of testis of immature rats. Decrease in the activities of sorbitol dehydrogenase and hyaluronidase was observed in both immature and mature rats. Decrease in the number of spermatids and increase in size of spermatocytes nuclei were observed. It is concluded that aspirin causes impairment of the later stages of spermatogenesis.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D002467:Cell Nucleus / Q000187:drug effects; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D007064:L-Iditol 2-Dehydrogenase / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D013087:Spermatids / Q000187:drug effects; D013090:Spermatocytes / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013737:Testis / Q000187:drug effects* / Q000201:enzymology
D007064:L-Iditol 2-Dehydrogenase; D006821:Hyaluronoglucosaminidase; D001241:Aspirin