title: [Effect of alpha-blocking agents on the internal anal sphincter muscle].
abstract: 47 patients with functional chronic constipation associated with an achalasia of the anal sphincter were treated with the alpha blocking agent Phenoxybenzamin. Dosages were used according to the manufacturers' instructions. 29 of the children were completely cured. There was significant improvement in a further 13 children and only 5 patients showed no improvement. Treatment failures were associated with additional severe psychological disturbances for which psycho-therapeutic management was required.
mesh_terms: D000293:Adolescent; D001003:Anal Canal / Q000187:drug effects*; D002648:Child; D002675:Child, Preschool; D003248:Constipation / Q000188:drug therapy*; D005242:Fecal Incontinence / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008365:Manometry; D010643:Phenoxybenzamine / Q000494:pharmacology* / Q000627:therapeutic use
chemical_list: D010643:Phenoxybenzamine
vernacular_title: Die Wirkung von Alpha-Blockern auf den Musculus sphincter ani internus.