Methylprednisolone prior to cardiopulmonary bypass.
Patients undergoing cardiopulmonary bypass were randomly allocated to receive methylprednisolone 30 mg/kg in a single dose prior to bypass, or to a control group receiving saline. The effect of this treatment on 2,3-DPG and oxygen delivery to the tissues was determined. There was no difference between the groups in 2,3-DPG levels, P50 or oxygen availability, but the methylprednisolone group showed a highly significant difference in oxygen consumption immediately following cardiopulmonary bypass (p < 0.001) and a significant difference in serum phosphate levels in the immediate postoperative period (p < 0.05). Methylprednisolone levels were measured by radioimmunoassay, and these showed a rapid decline in the 4 hours following administration.
D000328:Adult; D000368:Aged; D001219:Aspartate Aminotransferases / Q000097:blood; D002315:Cardiopulmonary Bypass; D004163:Diphosphoglyceric Acids / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000378:metabolism / Q000627:therapeutic use*; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D010710:Phosphates / Q000097:blood; D011184:Postoperative Period; D011300:Preoperative Care
D004163:Diphosphoglyceric Acids; D010710:Phosphates; D001219:Aspartate Aminotransferases; D010100:Oxygen; D008775:Methylprednisolone