Biosynthesis in vitro of homarine and pyridine carboxylic acids in marine shrimp.
Minces and homogenates of muscle obtained from the marine shrimp Penaeus duorarum are capable of synthesizing homarine from [14C]glycine. Glycine carbon atoms are incorporated into homarine but not significantly into picolinate or quinolinate. [2-14C]Acetate is readily incorporated into quinolinate in the in vitro system but only slightly into homarine and not at all into picolinate. Quinolinic acid is rapidly methylated to N-methyl quinolinate which is not decarboxylated to form homarine. Procedures have been developed for the satisfactory separation of N-methyl quinolinate from homarine.
D000085:Acetates / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D033364:Decapoda / Q000378:metabolism*; D005998:Glycine / Q000378:metabolism; D010848:Picolinic Acids / Q000096:biosynthesis* / Q000378:metabolism; D011805:Quinolinic Acids / Q000378:metabolism
D000085:Acetates; D000596:Amino Acids; D002250:Carbon Radioisotopes; D010848:Picolinic Acids; D011805:Quinolinic Acids; C010981:homarine; D005998:Glycine