[Effect of methanol, ethanol, propanol, chloral hydrate, and potassium chloride on the stability of rabbit skeletal muscle actomyosin].
The denaturation time (DT) of rabbit natural actomyosin (AM) and of actomyosin thread models has been detected under conditions of storage in the presence of methanol, ethanol, propanol, chloralhydrate or potassium chloride. DT--is the period of time during which, with the addition of ATP, actomyosin preparations maintain their ability to superprecipitation, and thread models--to contraction. All the organic substances examined taken in definite concentrations, were shown to increase the actomyosin DT as compared with the control probes. The greatest increase of DT was observed with the concentrations of methanol, ethanol and propanol being 8, 4 and 2% (v/v), resp. A dependence of the actomyosin DT on KCl concentration was noted. The thread model DT increased in the presence of ethanol--4% (v/v), and chloralhydrate--0.1 and 0.2% (v/v).
D000433:1-Propanol / Q000494:pharmacology; D000205:Actomyosin; D000818:Animals; D002697:Chloral Hydrate / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D000432:Methanol / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D011487:Protein Conformation / Q000187:drug effects; D011489:Protein Denaturation / Q000187:drug effects; D011817:Rabbits
D000431:Ethanol; D002697:Chloral Hydrate; D011189:Potassium Chloride; D000205:Actomyosin; D000433:1-Propanol; D000432:Methanol
Vliianie metanola, étanola, propanola, khloralgidrata i khloristogo kaliia na stabil'nost' aktomiozina skeletnykh myshts krolika.