title: Umbilical blood flow response to embolization of the uterine circulation.
abstract: The uterine and umbilical blood flow response to uteroplacental insufficiency, produced by microsphere embolization of the uteroplacental circulation, was examined by means of electromagnetic flow transducers in 12 pregnant ewes. No acute changes were observed in either circulation immediately after embolization of the uterine vasculature. Significant morphometric fetal growth retardation, in terms of weight, length, and ponderal index, was not associated with early changes in fetal pH, PO2, or PCO2. However, the incremental increases in both flows that were observed in control animals did not occur either during or after embolization because of an increase in vascular resistance. During and after embolization the incremental increase in uterine blood flow was blunted or decreased in most, but not all, animals. A rapid, progressive, and persistent decrease in umbilical flow occurred in the growth-retarded group. The significance of these findings relative to intrauterine growth is discussed.
mesh_terms: D000818:Animals; D001775:Blood Circulation; D004617:Embolism / Q000503:physiopathology; D005260:Female; D005317:Fetal Growth Retardation / Q000503:physiopathology*; D008431:Maternal-Fetal Exchange; D010927:Placental Insufficiency / Q000209:etiology; D011247:Pregnancy; D012756:Sheep; D014599:Uterus / Q000098:blood supply*; D014655:Vascular Resistance