HLA-B14 antigen and postencephalitic Parkinson's disease. Their association in an American-Jewish ethnic group.
Eighteen unrelated American-Jewish patients of Eastern European extraction who had classical postencephalitic Parkinson's disease were typed for HLA-A, HLA-B, and HLA-C antigenic determinants. Compared with 147 ethnically matched controls, the HLA-B14 antigen showed a highly significantly increased frequency in the postencephalitic Parkinson's group (corrected P = .001). This association, though not necessarily reflecting genetic susceptibility to the disease, strongly suggests such a possibility in the pathogenesis of at least this particular variant of parkinsonism.
D000917:Antibody Formation; D000956:Antigens, Viral / Q000276:immunology; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D007585:Jews; D009519:New York City; D010301:Parkinson Disease, Postencephalitic / Q000235:genetics* / Q000276:immunology; D010641:Phenotype
D000956:Antigens, Viral; D006680:HLA Antigens