Inhibition of brain synaptosomal uptake of choline by some 2-carboxamidostrychnine derivatives with muscle-relaxant properties.
Some 2-carboxamido derivatives of strychnine with a peripheral muscle-relaxant effect in vivo and in vitro were tested for their ability to inhibit choline (Ch) uptake into mouse brain synaptosomes. A non-competitive inhibition of the high affinity Ch uptake by strychnine and some of its derivatives was observed.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D002794:Choline / Q000378:metabolism*; D066298:In Vitro Techniques; D051379:Mice; D009125:Muscle Relaxants, Central / Q000494:pharmacology*; D013331:Strychnine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013574:Synaptosomes / Q000378:metabolism*
D009125:Muscle Relaxants, Central; D013331:Strychnine; D002794:Choline