title: On the pathogenesis of intestinal aganglionosis. A consideration based on electron microscopic observations of experimental and clinical aganglionoses.
abstract: A close resemblance in fine structure was observed between the aganglionic colon, produced in rats by serosal application of 0.1% benzalkonium chloride solution, and the aganglionic descending colon, or more proximal segments, of Hirschsprung's disease. The pathogenesis of the disease is discussed.
mesh_terms: D000818:Animals; D001548:Benzalkonium Compounds; D002648:Child; D002675:Child, Preschool; D003094:Collagen / Q000032:analysis; D003106:Colon / Q000648:ultrastructure*; D004195:Disease Models, Animal; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008531:Megacolon / Q000139:chemically induced / Q000473:pathology*; D008854:Microscopy, Electron; D051381:Rats
chemical_list: D001548:Benzalkonium Compounds; D003094:Collagen