title: The role of hyperoxygenation in facilitating the induction of pulmonary histiocytosis by low doses of chlorphentermine.
abstract: Hyperoxygenation modified the susceptibility of neonatal rat lung to respond to chlorphenatermine with an accumulation of hypertrophic macrophages, a morphologic change undetected when an anorectic drug was given alone. Implications of this observation for pediatrics are discussed.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002745:Chlorphentermine / Q000633:toxicity*; D005260:Female; D005487:Foam Cells / Q000473:pathology; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D008206:Lymphatic Diseases / Q000209:etiology* / Q000473:pathology; D010100:Oxygen; D010645:Phentermine / Q000031:analogs & derivatives*; D051381:Rats
chemical_list: D010645:Phentermine; D002745:Chlorphentermine; D010100:Oxygen