The effect of systemic acidosis on perfusion of replanted extremities.
By measuring skin temperature and muscle pH of replanted rat legs, we found that uncorrected systemic acidosis had a detrimental effect on perfusion of the replanted extremity. Following administration of systemic sodium bicarbonate and correction of acidosis, muscle pH and skin temperature returned to normal with 60 minutes after revascularization. Metabolic acidosis following major extremity replantation and respiratory acidosis after prolonged anesthesia for digital replantation(s) must be corrected to ensure optimal perfusion of the distal capillary bed.
D000138:Acidosis / Q000150:complications* / Q000188:drug therapy; D000818:Animals; D001639:Bicarbonates / Q000627:therapeutic use; D001831:Body Temperature; D002196:Capillaries; D006614:Hindlimb / Q000098:blood supply / Q000601:surgery*; D006863:Hydrogen-Ion Concentration; D008297:Male; D051381:Rats; D012039:Regional Blood Flow; D012092:Replantation / Q000379:methods*
D001639:Bicarbonates