title: Whole-body distribution an Malpighian tubule transport of 2',5-dichloro-4'-nitrosalicylanilide (Bayer 73) and 3-trifluoromethyl-4-nitrophenol in larvae of the aquatic midge Chironomus tentans.
abstract: 1. Residues of the lampricides 14C-Bayer 73 (2',5-dichloro-4'-nitrosalicylanilide) and 14C-TFM (3-trifluoromethyl-4-nitrophenol) were absorbed from aqueous sublethal concn. by aquatic larvae of the midge Chironomus tentans. 2. Toxicant residues were widely distributed during early hours of exposure, but later and during a 24-h post-exposure period, they became concentrated in the trunk and intestinal tract; the posterior movement of Bayer 73 was more rapid than that of TFM. 3. During 4-h tests, Malpighian tubules of the chironomid actively transported Bayer 73 and TFM in vitro, and on a per tubule basis, more TFM was transported than Bayer 73. 4. Potassium cyanide inhibited tubule transport; serotonin had no effect.
mesh_terms: D000818:Animals; D002683:Chironomidae; D002988:Cloaca / Q000378:metabolism*; D004463:Ecology; D008317:Malpighian Tubules / Q000378:metabolism*; D009534:Niclosamide / Q000378:metabolism*; D009596:Nitrophenols / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D009596:Nitrophenols; D009534:Niclosamide; C003687:3-trifluoromethyl-4-nitrophenol