title: [Comparative effects of 17 beta-oestradiol and ethinyl-oestradiol on plasma triglycerides in female rats (author's transl)].
abstract: Changes in plasma triglyceride levels were observed in female rats after castration and subsequent administration of incremental doses of 17 beta-oestradiol by injection or ethinyl-oestradiol orally. Castration significantly increased blood triglyceride levels and the dose of injected oestradiol which suppressed the effects of castration on vaginal smears and uterine weight also suppressed its effects on triglycerides. However, the oral dose of ethinyl-oestradiol which abolished the effects of castration on the genital tract further increased the levels of triglycerides. Differences in hepatic distribution of the two forms of oestrogen treatment may explain these discordant results.
mesh_terms: D000818:Animals; D002369:Castration; D004305:Dose-Response Relationship, Drug; D004958:Estradiol / Q000494:pharmacology*; D004997:Ethinyl Estradiol / Q000494:pharmacology*; D005260:Female; D051381:Rats; D014280:Triglycerides / Q000097:blood*; D014599:Uterus / Q000187:drug effects; D014621:Vagina / Q000187:drug effects
chemical_list: D014280:Triglycerides; D004997:Ethinyl Estradiol; D004958:Estradiol
vernacular_title: Effets comparés de l'estradiol 17 beta et de l'éthinyl-estradiol sur la triglycéridémie.