Cutaneous biometrics I. The response of human skin to dimethyl sulphoxide.
The wealing response of human skin to dimethyl sulphoxide (DMSO) has been quantified. Concentrations of 90%, 95% and 100% were applied for 5 min circular areas 8 min in diameter. Wealing was scored on a five-point scale after 10 min. Marked individual variations were found. Wealing was strongly influenced by body region and was dose-dependent. The intensity of the reaction paralleled that to other irritants and was dependent mainly on thickness and integrity of the horny layer. The DMSO test is a simple, quick way to assess the barrier function of the stratum corneum.
D000293:Adolescent; D000328:Adult; D044383:Black People; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D011565:Psoriasis / Q000503:physiopathology; D012621:Seasons; D012867:Skin / Q000098:blood supply / Q000187:drug effects*; D012882:Skin Tests; D012915:Soaps / Q000494:pharmacology; D013997:Time Factors; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D012915:Soaps; D003189:p-Methoxy-N-methylphenethylamine; D004837:Epinephrine; D004121:Dimethyl Sulfoxide