Deep vein thrombosis and changes in coagulation and fibrinolysis after gynaecological operations in Chinese: the effect of oral contraceptives and malignant disease.
Of 154 Chinese patients who underwent gynaecological operations, four showed a positive 125I fibrinogen leg scan for venous thrombosis, and overall incidence of 2 . 6%. In those who were on oral contraceptives and had major pelvic surgery for benign conditions, the incidence was 10 . 5%; in those who had Wertheim hysterectomy for carcinoma of cervix, it was 6 . 7%. This confirms the rarity of post-operative thromboembolism in the Chinese. Fragment E showed a biphasic rise after major operation due to tissue injury and venous thrombosis. In patients with malignancy, the postoperative 'fibrinolytic shutdown', represented by decreased plasminogen activator together with increased alpha 1 antitrypsin and C1- inhibitor levels, was more marked. In addition, alpha 2 macroglobulin level was lower and fell significantly after operation. In patients on oral contraceptives, fragment E levels were higher after surgery and there was no decrease in plasminogen activator levels. Antithrombin III levels did not fall except in three of the four patients with venous thrombosis. A marked increase in fragment E level and a decrease in antithrombin III level might be useful diagnostic markers for postoperative venous thrombosis.
D044466:Asian People; D001777:Blood Coagulation; D002681:China / Q000208:ethnology; D003276:Contraceptives, Oral / Q000009:adverse effects; D005260:Female; D005342:Fibrinolysis; D005831:Genital Diseases, Female / Q000601:surgery*; D006723:Hong Kong; D006801:Humans; D011183:Postoperative Complications; D011184:Postoperative Period; D013924:Thrombophlebitis / Q000209:etiology*; D002583:Uterine Cervical Neoplasms / Q000150:complications
D003276:Contraceptives, Oral