Immediate haemodynamic and metabolic effects of intravenous labetalol in the exercising forearm.
Dynamic forearm exercise was performed in healthy subjects before and after intravenous labetalol, 1 mg/kg body weight. Labetalol produced a sustained fall in arterial blood pressure. Forearm blood flow decreased by 17.2% partly due to the reduced driving pressure and partly due to an increased vascular resistance. Forearm oxygen uptake decreased by 14.6%, suggesting an increased mechanical efficiency. Lactate release from the exercising forearm decreased by 17.6%. Forearm uptake of glucose and free fatty acids remained unchanged.
D001794:Blood Pressure / Q000187:drug effects; D004983:Ethanolamines / Q000494:pharmacology*; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005542:Forearm / Q000098:blood supply / Q000378:metabolism; D005947:Glucose / Q000378:metabolism; D006801:Humans; D007741:Labetalol / Q000494:pharmacology*; D007773:Lactates / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects; D005082:Physical Exertion; D012039:Regional Blood Flow / Q000187:drug effects
D004983:Ethanolamines; D005230:Fatty Acids, Nonesterified; D007773:Lactates; D005947:Glucose; D007741:Labetalol