Oesophageal ulceration due to emepronium bromide.
Four cases of oesophageal damage associated with ingestion of the urinary anti-spasmodic agent emepronium bromide are described. All the patients presented with severe retrosternal pain worsened by swallowing food and drink, and in every case fibre-optic endoscopy revealed ulceration of the midoesophagus. Symptoms disappeared rapidly following cessation of emepromium bromide therapy. The means whereby this agent might injure oseophageal mucosa are discussed.
D000328:Adult; D000368:Aged; D004629:Emepronium / Q000009:adverse effects*; D004935:Esophageal Diseases / Q000139:chemically induced* / Q000175:diagnosis; D004941:Esophagitis / Q000139:chemically induced / Q000175:diagnosis; D004945:Esophagoscopy; D005260:Female; D006801:Humans; D008297:Male; D000644:Quaternary Ammonium Compounds / Q000009:adverse effects*; D014456:Ulcer / Q000139:chemically induced; D014555:Urination Disorders / Q000188:drug therapy
D000644:Quaternary Ammonium Compounds; D004629:Emepronium