Isobologram analysis of the combined effects of anti-tumour platinum complexes and ionizing radiation on mammalian cells.
Chinese hamster ovary cells have been treated in vitro with the platinum coordination complexes cis-PAD or CHIP and with radiation, either alone or in combination with different doses and time intervals. The isobologram method has been used to make a graphic comparison of these combined-modality data in terms of additivity and enhancement. The data showed enhancement of the radiation effect by these platinum complexes in many combinations, and a truly synergistic effect in one case. This method of analysis points to the limited usefulness of the parameter dose-modifying effect (DMF) since the most synergistic combination did not have the highest DMF.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects*; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D003517:Cyclopentanes / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005720:Gamma Rays; D008433:Mathematics; D009944:Organoplatinum Compounds / Q000494:pharmacology*; D010053:Ovary / Q000166:cytology; D011838:Radiation-Sensitizing Agents / Q000494:pharmacology*; D013997:Time Factors
D000970:Antineoplastic Agents; D003517:Cyclopentanes; D009944:Organoplatinum Compounds; D011838:Radiation-Sensitizing Agents; C011764:dichlorobis(cyclopentylamine)platinum; C023359:iproplatin