[Stability of sulbenicillin and cefacetrile in bile (author's transl)].
The antibiotic activity of sulbenicillin and cefacetrile was determined after storage at -20 degrees C for up to 7 days in human gall-bladder and common duct bile. In gall-bladder bile, both drugs could not retain their initial activity after 3 days. The decay curves in antibiotic activity in the ductal bile revealed large variations, as given in Figs. 5 and 6. The 7th day activity of both drugs decreased with the rise in initial pH level of bile. Significant correlation was noted between bile acid concentration in bile and cefacetrile activity on the 7th day.
D001646:Bile / Q000032:analysis*; D002505:Cephacetrile / Q000032:analysis*; D002511:Cephalosporins / Q000032:analysis*; D004355:Drug Stability; D006801:Humans; D006863:Hydrogen-Ion Concentration; D066298:In Vitro Techniques; D010400:Penicillin G / Q000031:analogs & derivatives*; D013408:Sulbenicillin / Q000032:analysis*; D013997:Time Factors
D002511:Cephalosporins; D002505:Cephacetrile; D013408:Sulbenicillin; D010400:Penicillin G