title: Differential effects of methylphenidate on signalled and non-signalled reinforcement.
abstract: Rats were trained to press a bar with water reinforcement under a variable interval 15-sec (VI 15), variable interval 15-sec signalled-reinforcement (VI SD), or a differential-reinforcement-of-low-rate 10-sec (DRL 10) schedule. Methylphenidate (MP) had little effect on response rates or reinforcements-earned in the VI 15 group. However, MP increased response rates in a dose-related manner in the VI SD and the DRL 10 groups. These findings and additional results reported in the literature suggest that signalled reinforcement does not necessarily antagonize the rate-increasing effects of the amphetamine-type drugs.
mesh_terms: D000818:Animals; D003216:Conditioning, Operant / Q000187:drug effects*; D003463:Cues; D005108:Extinction, Psychological / Q000187:drug effects; D008297:Male; D008774:Methylphenidate / Q000494:pharmacology*; D051381:Rats; D012055:Reinforcement Schedule
chemical_list: D008774:Methylphenidate