Effects of propafenone on TEA-induced action potentials in vascular smooth muscle of canine coronary arteries.
The Ca++-dependent, TEA-induced action potential is blocked by propafenone in a dose-dependent manner. Such results suggests that in coronary arterial smooth muscle one mechanism of action of propafenone is to inhibit Ca++ inward current.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000502:physiology*; D002118:Calcium / Q000494:pharmacology; D003331:Coronary Vessels / Q000187:drug effects / Q000502:physiology*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology; D011405:Propafenone; D011427:Propiophenones / Q000494:pharmacology*; D013757:Tetraethylammonium Compounds / Q000494:pharmacology*
D011427:Propiophenones; D013757:Tetraethylammonium Compounds; D011405:Propafenone; D002118:Calcium