Local leukocyte mobilization in irradiated or cyclophosphamide-treated rats.
Sprague-Dawley rats made neutropenic by 60Co irradiation or cyclophosphamide treatment retained a limited capacity for mounting a local leukocyte mobilization (LLM) response. Rats irradiated with 700 rad 60Co lacked an LLM. Rats treated with 100 mg/kg cyclophosphamide showed no LLM following an initial low response when assayed originally.
D000380:Agranulocytosis / Q000097:blood*; D000818:Animals; D002465:Cell Movement / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D009503:Neutropenia / Q000097:blood*; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects*; D051381:Rats
D008070:Lipopolysaccharides; D003520:Cyclophosphamide