Inhibitory effects of streptomycin on bronchoconstrictor, hypotensive and inflammatory responses to bradykinin and histamine.
Streptomycin inhibits significantly the bronchoconstrictor effects of bradykinin and histamine. This effect of streptomycin is probably through the relaxation of bronchiolar smooth muscle. The hypotensive and inflammatory responses to bradykinin and histamine are also significantly suppressed with streptomycin. This is thought to be due to the decreased vascular permeability to streptomycin.
D000403:Airway Resistance / Q000187:drug effects*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001920:Bradykinin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D001980:Bronchi / Q000187:drug effects; D006168:Guinea Pigs; D006632:Histamine / Q000494:pharmacology; D006633:Histamine Antagonists; D066298:In Vitro Techniques; D007249:Inflammation / Q000139:chemically induced / Q000503:physiopathology*; D013307:Streptomycin / Q000494:pharmacology*; D013997:Time Factors
D006633:Histamine Antagonists; D006632:Histamine; D001920:Bradykinin; D013307:Streptomycin