The mechanism of the motor response to periarterial nerve stimulation in the small intestine of the rabbit.
In the presence of guanethidine, periarterial nerve stimulation caused a frequency-dependent motor response in the rabbit isolated ileum. Tachyphylaxis to capsaicin greatly diminished the effect of periarterial stimulation; the remaining portion of the contractile response was susceptible to hexamethonium. The motor effect of periarterial stimulation is mediated by two different mechanisms: one via parasympathetic preganglionic nerves and the other sensitive to capsaicin.
D000818:Animals; D001158:Arteries; D002211:Capsaicin / Q000494:pharmacology; D004558:Electric Stimulation; D006145:Guanethidine / Q000494:pharmacology; D006584:Hexamethonium Compounds / Q000494:pharmacology; D066298:In Vitro Techniques; D007421:Intestine, Small / Q000187:drug effects / Q000294:innervation*; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D011817:Rabbits
D006584:Hexamethonium Compounds; D002211:Capsaicin; D006145:Guanethidine