[Effect of nonachlazine on the cardiac component of baroreceptor reflexes in unanesthetized cats].
Nonachlazin in doses of 1 and 6 mg/kg provoked a rise in the arterial pressure of cats by 7--20 mm Hg. Administration of 1 mg nonaclazin into the IV ventricle induced a similar elevation of arterial pressure. Premedication with propranolol (1--3 mg/kg) did not prevent the pressor reaction. In half of the experiments, nonachlazin (6 mg/kg) produced an appearance of Meyer's waves and inhibition of the cardiac component of the barorecptor reflex that is not related to the potentiation of the sympathetic effects on the heart.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D002415:Cats; D004347:Drug Interactions; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D007545:Isoproterenol / Q000008:administration & dosage; D008297:Male; D009628:Nonachlazine / Q000008:administration & dosage / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology*; D011311:Pressoreceptors / Q000502:physiology*; D011433:Propranolol / Q000008:administration & dosage; D012018:Reflex / Q000187:drug effects*; D013318:Stroke Volume / Q000187:drug effects
D010640:Phenothiazines; D009628:Nonachlazine; D011433:Propranolol; D007545:Isoproterenol
Vliianie nonakhlazina na serdechnyĭ komponent baroretseptivnogo refleksa u nenarkotizirovannykh koshek.