[System regulating lipid oxidation and the state of the nuclear membrane during tumor growth].
Changes of antioxidative activity (AOA), lipid composition and membrane structure in tumour cell nuclei and in the liver of tumour-carrier during the development of Ehrlich ascite carcinoma (EAC) were studied. On the basis of the data obtained the work of physico-chemical system of oxidative reactions in lipids was analysed. This control system involves a relationship between AOA changes, lipid composition, their oxidative ability and the nuclear membrane structure. It was shown that with EAC development in the cell nuclei of the tumour-carrier liver the control system under study is functioning like in the normal state. In EAC cell nuclei in the course of tumour growth there proceeds a change in the relationship AOA -- lipid composition -- membrane structure, the primary disturbance in the system appearing evidently within the link AOA -- lipid composition.
D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002467:Cell Nucleus / Q000032:analysis; D002784:Cholesterol / Q000032:analysis; D050356:Lipid Metabolism; D008055:Lipids / Q000032:analysis; D008099:Liver / Q000378:metabolism*; D008563:Membrane Lipids / Q000032:analysis; D051379:Mice; D008815:Mice, Inbred Strains; D009685:Nuclear Envelope / Q000032:analysis; D010084:Oxidation-Reduction; D013109:Sphingomyelins / Q000032:analysis; D014783:Viscosity
D008055:Lipids; D008563:Membrane Lipids; D013109:Sphingomyelins; D002784:Cholesterol
Sistema reguliatsii okisleniia lipidov i sostoianiia iadernoĭ membrany pri opukholevom roste.