The effect of Apamin on nonadrenergic, noncholinergic nervous vasodilatations in the cat small intestine.
The intestinal vasodilation evoked by mechanical mucosal stimulation or by transmural electrical field stimulation was abolished by close i.a. injection of Apamin, a polypeptide originally isolated from bee venom. Apamin also blocked the vasodilatation induced by close i.a. infusion of vasoactive intestinal polypeptide (VIP). It is suggested that Apamin is a VIP receptor antagonist.
D000818:Animals; D001030:Apamin / Q000494:pharmacology*; D001514:Bee Venoms / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D002415:Cats; D007413:Intestinal Mucosa / Q000098:blood supply* / Q000187:drug effects; D007421:Intestine, Small / Q000098:blood supply* / Q000187:drug effects; D014664:Vasodilation / Q000187:drug effects*
D001514:Bee Venoms; D001030:Apamin