title: Lobular endocrine neoplasia in fibroadenoma of the breast.
abstract: Four cases of endocrine neoplasia within fibroadenomas of the breast are described. The tumours are identifiable by light microscopic, silver impregnation and ultrastructural studies. Argyrophilia and the presence of dense-core granules establish the identity of this tumour type. The differential diagnosis from, and possible relation to, lobular carcinoma in situ are discussed.
mesh_terms: D000232:Adenofibroma / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D001943:Breast Neoplasms / Q000473:pathology*; D004700:Endocrine System Diseases / Q000473:pathology*; D004759:Enterochromaffin Cells / Q000648:ultrastructure; D005260:Female; D006801:Humans; D008854:Microscopy, Electron