title: The effect of intravenous glucose on human fetal breathing measured by Doppler ultrasound.
abstract: Fetal breathing movements were recorded from 24 normal fetuses using the continuous Doppler ultrasound method. This system has been improved by the addition of a microprocessor which facilitates the accurate determination of breath to breath intervals. A control group of twelve patients in late pregnancy received 2 ml sterile water. By comparison the administration of 25 g intravenous glucose to a similar group of 12 patients caused an increase in the proportion of time during which fetal breathing was present from 18.2 +/- 5.8 per cent (mean +/- SE) to 67.0 +/- 6.3 per cent after 25 minutes (p < 0.001). There was no significant change in the rate or variability of breathing.
mesh_terms: D004301:Doppler Effect; D005260:Female; D005333:Fetus / Q000187:drug effects / Q000502:physiology*; D005947:Glucose / Q000008:administration & dosage / Q000494:pharmacology*; D006801:Humans; D007263:Infusions, Parenteral; D011247:Pregnancy; D012119:Respiration / Q000187:drug effects*; D014463:Ultrasonography
chemical_list: D005947:Glucose