title: Metal sensitivity in patients undergoing hip replacement. A prospective study.
abstract: A prospective study of allergic contact dermatitis after metal-on-plastic total hip replacement was undertaken in 69 patients, of whom 54 were available for review after operation. Before operation six patients were metal sensitive, but only one remained so afterwards; this patient had given a clear history of metal sensitivity and a titanium prosthesis had therefore been used. In all six patients the result of the operation was good and no case of loosening occurred. Sixty-three patients had negative patch tests before operation; in none of these was metal sensitivity detected after operation. Cutaneous sensitivity to various metals is well documented after the insertion of metal-on-metal prostheses and in failed prostheses. We have not found any such increased sensitivity after metal-on-plastic hip replacement. There is little evidence of a direct causal relationship between metal sensitivity and subsequent loosening. The cutaneous sensitivity may be the consequence of loosening rather than its cause. Our results suggest that, providing metal-on-plastic prostheses are used, routine patch testing before hip replacement is no longer required.
mesh_terms: D005260:Female; D006622:Hip Prosthesis / Q000009:adverse effects; D006801:Humans; D006967:Hypersensitivity / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D008670:Metals / Q000009:adverse effects*; D011095:Polyethylenes; D011300:Preoperative Care; D011446:Prospective Studies; D012882:Skin Tests
chemical_list: D008670:Metals; D011095:Polyethylenes