Antitumor structure-activity relations. Nitrosoureas vs. L-1210 leukemia.
A quantitative structure-activity relationship (QSAR) for 90 nitrosoureas acting against L-1210 leukemia in mice has been formulated. This QSAR is compared with one correlating the LD10 of 96 nitrosoureas. The results indicate that neutral nitrosoureas with octanol/water partition coefficients in the range of -1.5 to -2.5 might have better therapeutic indices than those currently in use.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D007939:Leukemia L1210 / Q000188:drug therapy*; D051379:Mice; D008962:Models, Theoretical; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D012995:Solubility; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D009607:Nitrosourea Compounds