title: [Mathematical model of the dose-time-effect relationship in the intramuscular administration of testosterone esters].
abstract: Two equations of the dose-time-effect dependence during repeated intramuscular injections of testosterone esters are presented. The equation coefficients characterizing both properties of the drugs injected and individual features of the organs exposed to their action are interpreted. Moreover, two equations for calculating duration of the mitotic cycle of the test organ cells are given.
mesh_terms: D000818:Animals; D002369:Castration; D004305:Dose-Response Relationship, Drug; D007273:Injections, Intramuscular; D008297:Male; D008433:Mathematics; D008938:Mitosis / Q000187:drug effects; D008954:Models, Biological; D051381:Rats; D013739:Testosterone / Q000008:administration & dosage*; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D013739:Testosterone
vernacular_title: Matematicheskaia model' zavisimosti doza-vremia-éffekt pri vnutrimyshechnom vvedenii éfirov testosterona.