Protein anabolism in endometrium and myometrium during the growth of induced deciduoma in rats.
Protein anabolism in the endometrium and myometrium was studied during the growth of induced deciduoma in terms of incorporation of [14C]-leucine into proteins. The data show that the specific activity of the proteins was highest 2 days after decidualisation. Protein synthesis in the endometrium studied on that day as a function of time after injection of the labelled amino acid showed a steady increase during the first 2 h. Cycloheximide (2 mg/kg b.wt) administration produced nearly 95% inhibition of protein synthesis in endometrium as well as in myometrium.
D000818:Animals; D003513:Cycloheximide / Q000494:pharmacology; D004717:Endometrium / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D007700:Kinetics; D009215:Myometrium / Q000187:drug effects / Q000378:metabolism*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects; D014176:Protein Biosynthesis; D011555:Pseudopregnancy / Q000378:metabolism*; D051381:Rats; D014599:Uterus / Q000378:metabolism*
D003513:Cycloheximide