Effects of aspirin and related drugs in vitamin E-deficient rats.
Evidence from the literature indicates that in vitamin E-deficient animals prostaglandin (PG) synthesis in platelets is enhanced while it is decreased in the muscle and testis. In the present study the effects of aspirin, a known inhibitor of PG biosynthesis, on vitamin E deficiency signs in the rat were investigated. Administration of aspirin to vitamin E-deficient rats had no protective effect on fetal mortality, incisor depigmentation, body weight gain or red blood cell peroxidative hemolysis. Aspirin prevented the anemia and thrombocythemia observed in vitamin E-deficient rats. Aspirin, salicylic acid and a carbazole prostaglandin inhibitor exacerbated testis degeneration in vitamin E-deficient animals. Addition of aspirin to the diet more than doubled the vitamin E requirement for reversal of necrotizing myopathy.
D000818:Animals; D001241:Aspirin / Q000494:pharmacology*; D001772:Blood Cell Count; D005260:Female; D005313:Fetal Death / Q000209:etiology; D006400:Hematocrit; D006454:Hemoglobins / Q000378:metabolism; D006461:Hemolysis; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000378:metabolism*; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D012459:Salicylates / Q000494:pharmacology*; D013737:Testis / Q000473:pathology; D014811:Vitamin E Deficiency / Q000503:physiopathology*
D006454:Hemoglobins; D011453:Prostaglandins; D012459:Salicylates; D001241:Aspirin