Cigarette smoke affects lipolytic activity in isolated rat lungs.
Isolated perfused rat lungs liberated fatty acids at a rate of 15 mumol/hr during perfusion of triglyceride-rich medium through the pulmonary vascular bed. About 80% of this activity seemed to result from lipoprotein lipase and 20% to hormone-sensitive lipase. Ventilation of the lungs with cigarette smoke instead of air during the perfusion reduced fatty acid liberation by 23%. Pre-exposure of rats to cigarette smoke for either 1 or 10 days did not cause significant changes in lung lipolytic activity compared to sham-exposed controls.
D000818:Animals; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D007700:Kinetics; D008066:Lipolysis; D008071:Lipoprotein Lipase / Q000378:metabolism*; D008168:Lung / Q000378:metabolism*; D008297:Male; D010477:Perfusion; D010947:Plants, Toxic; D051381:Rats; D012906:Smoke; D014026:Nicotiana; D014280:Triglycerides / Q000378:metabolism
D005230:Fatty Acids, Nonesterified; D012906:Smoke; D014280:Triglycerides; D008071:Lipoprotein Lipase