[Effect of dopamine on renal and intrarenal hemodynamics in unilateral ureteral occlusion].
Renal and intrarenal hemodynamics were studied over a period of 6 months in the hydronephrotic dog kidney after unilateral complete ligation of the ureter. Already 7 hours after ligation renal blood flow was reduced. The intrarenal blood flow distribution changed with a massive reduction in cortical and only slight decrease in medullary perfusion. This alteration of intrarenal blood flow resulted in a change of the compartment fractions. Dopamine, applied intravenously in a dose of 4 micrograms kg-1 min-1, induced a vasodiilation of the obstructed kidney during the whole period of investigation. Especially the reduced cortical blood flow could be improved by the application of dopamine.
D000818:Animals; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology* / Q000627:therapeutic use; D006439:Hemodynamics / Q000187:drug effects*; D006869:Hydronephrosis / Q000188:drug therapy; D007668:Kidney / Q000098:blood supply*; D014517:Ureteral Obstruction / Q000503:physiopathology*
D004298:Dopamine
Die renale und intrarenale Hämodynamik bei unilateraler Ureterokklusion und deren Beeinflussung durch Dopamin.