C(14)-fluorinated prostaglandins: synthesis and biological evaluation of the methyl esters of (+)-14-fluoro-, (+)-15-epi-14-fluoro-, (+)-13(E)-14-fluror-, and (+)-13(E)-15-epi-14-fluoroprostaglandin F2 alpha.
The synthesis and biological evaluation of the methyl esters of (+)-14-fluoroPGF2 alpha, (+)-15-epi-14-fluoroPGF2 alpha, (+)-13(E)-14-fluoroPGF2 alpha, and (+)-13(E)-15-epi-14-fluoroPGF2 alpha are described. Each fluoroprostaglandin has been evaluated for pregnancy interruption in the hamster and smooth-muscle stimulating effects on gerbil colon and hamster uterine strips.
D000020:Abortifacient Agents, Nonsteroidal / Q000138:chemical synthesis; D000818:Animals; D006224:Cricetinae; D005260:Female; D005849:Gerbillinae; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D011247:Pregnancy; D011461:Prostaglandins F, Synthetic / Q000138:chemical synthesis* / Q000494:pharmacology; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D014590:Uterine Contraction / Q000187:drug effects
D000020:Abortifacient Agents, Nonsteroidal; D011461:Prostaglandins F, Synthetic