Inhibition of calcium oxalate crystal growth in urine during treatment with allopurinol.
Twelve male patients with urolithiasis were treated with 300 mg allopurinol daily. Urinary urate decreased from 251 +/- 55 to 156 +/- 19 (mean +/- SD) mmol per mol creatinine. The inhibition of calcium oxalate crystal growth was measured in an in vitro system and the inhibition index increased from 0.51 +/- 0.06 to 0.57 +/- 0.08 (mean +/- SD). Urinary citrate excretion was unaffected by the treatment.
D000493:Allopurinol / Q000627:therapeutic use*; D002129:Calcium Oxalate / Q000652:urine*; D003460:Crystallization; D006801:Humans; D008297:Male; D014527:Uric Acid / Q000652:urine; D014545:Urinary Calculi / Q000188:drug therapy* / Q000652:urine
D002129:Calcium Oxalate; D014527:Uric Acid; D000493:Allopurinol