Evaluation of circulating immune complex-like material for development of skin reactions in connection with penicillin therapy.
The levels of immune complex-like material in serum from 18 patients in connection with skin eruptions appearing during penicillin therapy were determined with a modified ELISA. Immune complex-like material could only be shown in the serum of 3 out of the 17 patients. However, according to ELISA results, the complexes appeared without the simultaneous presence of penicilloyl-specific antibodies. Neither could penicilloyl-specific antibodies be recorded in 9 patient treated with parenteral penicillin without adverse reactions. 3 of these patients had immune complex-like material in their serum. It was concluded that immune complex-like material with penicilloyl specificity is not likely to contribute to the development of skin eruptions often seen in connection with penicillin treatment.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex; D002648:Child; D006386:Hemagglutination Tests; D006801:Humans; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008875:Middle Aged; D010406:Penicillins / Q000009:adverse effects* / Q000276:immunology; D011852:Radioallergosorbent Test; D012217:Rheumatoid Factor / Q000276:immunology; D012871:Skin Diseases / Q000209:etiology / Q000276:immunology*; D012882:Skin Tests
D000936:Antigen-Antibody Complex; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D010406:Penicillins; D012217:Rheumatoid Factor