Interaction of diphenylhydantoin and some oral hypoglycemic drugs related to carbohydrate metabolism in rats.
Daily treatment of rats with 50 or 100 mg/kg ip of diphenylhydantoin (DPH) for 3 weeks caused a significant elevation of blood glucose level and reduction of hepatic glycogen content. In rats receiving daily oral doses of tolbutamide (100 mg/kg) or phenformin (50 mg/kg) for the last 7 days of DPH treatment, the blood glucose level did not differ from those in the control group; in rats receiving the low doses of DHP, the reduction in hepatic glycogen content was prevented by either hypoglycemic drug; in rats receiving the high dose of DPH in combination with the hypoglycemics the glycogen reduction was smaller than in rats receiving DPH alone. A week's treatment with tolbutamide (100 mg/kg) alone resulted in a significant depression of the blood glucose level and elevation of hepatic glycogen content; phenformin (50 mg/kg) given alone for one week elevated the level of hepatic glycogen, but to a lesser degree than tolbutamide did, and did not affect the blood glucose level.
D000284:Administration, Oral; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D004347:Drug Interactions; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D008112:Liver Glycogen / Q000378:metabolism*; D008297:Male; D010629:Phenformin / Q000494:pharmacology; D010672:Phenytoin / Q000494:pharmacology*; D051381:Rats; D014044:Tolbutamide / Q000494:pharmacology
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D008112:Liver Glycogen; D010672:Phenytoin; D014044:Tolbutamide; D010629:Phenformin