[Simultaneous therapy of gonorrhea with penicillin and probenecid. Serum penicillin picture].
19 patient received penicillin and probenecid. The resulting serum concentrations of penicillin was determined. In regimen I 4 mill. IU depot penicillin was given i.m. simultaneously with 1 g probenecid orally. In regimen II probenecid was given 30 min prior to the administration of penicillin. In both series the average serum concentrations of penicillin were not significantly different (p = 0.01).
D000293:Adolescent; D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010400:Penicillin G / Q000097:blood / Q000627:therapeutic use*; D011339:Probenecid / Q000627:therapeutic use*
D011339:Probenecid; D010400:Penicillin G
Simultane Gabe von Penizillin und Probenezid bei der Gonorrhöbehandlung. Untersuchungen von Penizillinserumspiegeln.