Enhancement by urine of urinary bladder carcinogenesis.
The role of urine as a tumor-enhancing agent in urinary bladder carcinogenesis was investigated by using the heterotopically transplanted rat urinary bladder. Bladders removed from rats initiated with the carcinogen N-butyl-N-(4-hydroxybutyl)nitrosamine in drinking water for 4 or 10 weeks were heterotransplanted to syngeneic rats. These heterotopically transplanted bladders receiving repeated instillations of normal rat urine subsequent to transplantation had a higher incidence of carcinoma than did those receiving 0.9% NaCl solution. These results suggest that normal urine may contain tumor promoter(s).
D000818:Animals; D002085:Butylhydroxybutylnitrosamine; D003043:Cocarcinogenesis; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000209:etiology; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000139:chemically induced / Q000209:etiology*; D014556:Urine / Q000502:physiology*
D002085:Butylhydroxybutylnitrosamine