[A new cyclohexylphenyl and cyclohexylphenylamine. Synthesis and pharmacological activity].
Derivatives of some primary amines and their N-benzyl derivatives containing a 4-cyclohexylphenyl or a 4-phenylcyclohexyl group were prepared. Pharmacological study showed clear analgesic activity in the phenylquinone test which was more accentuated for the 4-phenylcyclohexyl derivatives. All the compounds proved devoid of sympathomimetic activity on the cardiovascular system and without anorexic effect. Some of the compounds showed some antireserpine activity.
D000814:Aniline Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D001066:Appetite / Q000187:drug effects*; D001555:Benzene Derivatives / Q000138:chemical synthesis / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D003510:Cyclohexanes / Q000138:chemical synthesis / Q000494:pharmacology*; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects; D008297:Male; D010146:Pain / Q000188:drug therapy*; D051381:Rats; D012110:Reserpine / Q000037:antagonists & inhibitors
D000814:Aniline Compounds; D001555:Benzene Derivatives; D003510:Cyclohexanes; C028146:4-cyclohexylaniline; D012110:Reserpine
Nuove fenilcicloesil e cicloesilfenilammine. Sintesi e attività farmacologica.