Testicular atrophy induced by phthalic acid monoesters: effects of zinc and testosterone concentrations.
Induction of testicular atrophy by monoesters of phthalic acid were compared in male Wistar rats. Dietary administration of monobutyl (MBP), mono-iso-butyl (MIBP) and mono-2-ethylhexyl phthalate (MEHP) induced severe atrophy of the testes. Furthermore, high testosterone concentration in the testes was found in MBP- and MIBP-treated rats, whereas low zinc concentration was found in MBP-, MIBP- and MEHP-treated rats. On the other hand, in monooctyl phthalate (MOP)-treated rats, testosterone and zinc concentrations in the testes were not changed. These were similar to the results with their diesters.
D000818:Animals; D001284:Atrophy; D001835:Body Weight / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010795:Phthalic Acids / Q000633:toxicity*; D051381:Rats; D013733:Testicular Diseases / Q000139:chemically induced; D013737:Testis / Q000032:analysis / Q000473:pathology*; D013739:Testosterone / Q000032:analysis / Q000097:blood; D015032:Zinc / Q000032:analysis*
D010795:Phthalic Acids; D013739:Testosterone; D015032:Zinc