The use of chick embryo toxicity test (CHEST) in evaluating blood sera of patients treated with antidepressants.
The chick embryo toxicity test (CHEST) was used for detection of potential embryo-toxicity of inactivated blood sera of patients being treated with antidepressant drugs (amitryptiline, maprotiline). The preliminary data of testing sera of 17 patients within the period of three weeks, when stable plasma levels of examined compounds and their metabolites were undoubtedly reached, showed no significant embryotoxic effects.
D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects* / Q000097:blood; D002642:Chick Embryo; D004622:Embryo, Mammalian / Q000187:drug effects*; D006801:Humans; D008722:Methods
D000928:Antidepressive Agents