Hyperthyroidism in children. A reevaluation of treatment.
The results of medical and surgical therapy were determined in 107 hyperthyroid children. After surgery, 85% of patients were rendered free of hyperthyroidism; however, 62% became hypothyroid. After medical treatment, 30% of patients were euthyroid and 2% became hypothyroid. The relapse rate, however, was higher after medical (22%) than after surgical (9%) therapy. Serious drug-related complications (arthritis-, hepatitis-, and collagen disease-like syndromes) occurred in 14% of patients. Complications occurred in 9% of surgically treated patients, but recurrent laryngeal nerve injury or permanent hypoparathyroidism did not occur. In medically treated patients, both a goiter size less than three times normal prior to treatment and a reduction in goiter size to less than two times normal at the completion of therapy correlated with a successful outcome.
D000293:Adolescent; D001168:Arthritis / Q000139:chemically induced; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology; D002648:Child; D002675:Child, Preschool; D003095:Collagen Diseases / Q000139:chemically induced; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000188:drug therapy / Q000601:surgery*; D007037:Hypothyroidism / Q000209:etiology; D008297:Male; D008713:Methimazole / Q000627:therapeutic use; D011183:Postoperative Complications; D011441:Propylthiouracil / Q000009:adverse effects / Q000627:therapeutic use; D013965:Thyroidectomy
D008713:Methimazole; D011441:Propylthiouracil