Effect of muscimol on dopamine metabolism of the rat hypothalamus.
Muscimol, a potent GABA receptor agonist, produced increases in DOPAC and dopamine concentrations in the rat hypothalamus. GABAergic receptors, therefore, modulate hypothalamic dopaminergic neurones.
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009118:Muscimol / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats
D010080:Oxazoles; D015102:3,4-Dihydroxyphenylacetic Acid; D009118:Muscimol; D004298:Dopamine; D009638:Norepinephrine