title: [Pharmacology of prooxen].
abstract: Prooxen--9-(3-dimethylaminopropyliden) xanthene--administered in small doses (0.05-0.1 mg/kg) produces a central and peripheral adrenosensibilizing effect, diminishes the duration of hexenal sleep, disturbs the differentiation, and causes appearance of intersignal reactions in experiments with conditioned reflexes. The drug exerts an antireserpine action. In large doses (5 mg/kg and over) it displays a tranquilizing action, prolongs the narcotic action of hexenal and chloral hydrate. LD50 and LD100 of prooxen in mice are 280 and 350 mg/kg, respectively. As compared to damilen, prooxen exerts a more pronounced tranquilizing action, possesses less toxicity and less central M-cholinolytic activity.
mesh_terms: D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D000929:Antidepressive Agents, Tricyclic; D002415:Cats; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D051381:Rats; D011950:Receptors, Cholinergic / Q000187:drug effects; D012110:Reserpine / Q000037:antagonists & inhibitors; D013329:Structure-Activity Relationship; D013892:Thioxanthenes / Q000494:pharmacology; D013997:Time Factors; D014966:Xanthenes / Q000494:pharmacology* / Q000633:toxicity
chemical_list: D000929:Antidepressive Agents, Tricyclic; D011950:Receptors, Cholinergic; D013892:Thioxanthenes; D014966:Xanthenes; D000639:Amitriptyline; C011337:prothixene; C028105:prooxen; D012110:Reserpine
vernacular_title: K farmakologii prooksena.