title: Preliminary project of the standard minimal scope and methods of testing acute toxicity of industrial chemical substances.
abstract: The standard minimal scope of experimental toxicity evaluation of industrial chemicals has been proposed. On the basis of literature and own experience the authors propose that the minimal scope of toxicity testing should include determination of lethal doses and evaluation of morphological alterations of inner organs in acute experiments, as well as assessment of eye and skin irritation and contact sensitization. The main lines of uniform procedures are presented. Complementary tests of local and acute systemic toxicity are also recommended.
mesh_terms: D000818:Animals; D004781:Environmental Exposure; D004785:Environmental Pollutants / Q000633:toxicity*; D007221:Industry; D007928:Lethal Dose 50; D011817:Rabbits; D051381:Rats; D012867:Skin / Q000187:drug effects
chemical_list: D004785:Environmental Pollutants