Cardiopulmonary resuscitation in the nonhuman primate.
Seventeen adult male Cynamolgus monkeys were subjected to potassium chloride-induced cardiopulmonary arrests of 10 to 12 minutes. Pupils became dilated and fixed at a mean interval of 30 +/- 11 seconds, and the electroencephalogram became isoelectric at a mean interval of 34 +/- 13 seconds. The monkeys were resuscitated by means of oxygen, external cardiac message, epinephrine, calcium, and bicarbonate. The mean time required to resuscitate the monkeys was 140 +/- 70 seconds. After resuscitation, the monkeys were kept in an intensive care unit. Pupillary responsiveness and electroencephalographic activity were slow to return, with mean intervals of 90 +/- 85 and 108 +/- 36 minutes, respectively. Although all 17 monkeys were resuscitated, only 9 survived 96 hours or more. Of the 9 survivors, 2 appeared neurologically normal, 3 were moderately impaired, and 4 were severely impaired.
D000818:Animals; D004562:Electrocardiography / Q000662:veterinary; D006323:Heart Arrest / Q000503:physiopathology / Q000628:therapy / Q000662:veterinary*; D008251:Macaca; D008252:Macaca fascicularis / Q000502:physiology; D008297:Male; D008992:Monkey Diseases / Q000503:physiopathology / Q000628:therapy; D011189:Potassium Chloride; D011680:Pupil / Q000503:physiopathology; D012151:Resuscitation / Q000662:veterinary*; D013997:Time Factors
D011189:Potassium Chloride