The influence of diet-induced hypercholesterolemia on the degree of oxidation of glutathione in rabbit aorta.
In rabbits fed a cholesterol-rich diet for 4 weeks, an increased lipid peroxidation rate was found in plasma and aortic wall tissue. Furthermore, there was a significant increase of glutathione disulfide in aortic tissue indicating a mechanism whereby hypercholesterolemia may influence sulfhydryl group-dependent reactions of vessel wall metabolism.
D000818:Animals; D001011:Aorta / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D005978:Glutathione / Q000378:metabolism*; D006937:Hypercholesterolemia / Q000097:blood / Q000209:etiology / Q000378:metabolism*; D008297:Male; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D002791:Cholesterol, Dietary; D014280:Triglycerides; D002784:Cholesterol; D005978:Glutathione