title: [Cerebrospinal fluid (CSF) levels of chloramphenicol: a critical review (author's transl)].
abstract: Chloramphenicol was given to four neurosurgical patients intravenously. Serum and cerebrospinal fluid (CSF) concentrations were determined with High-pressure-Liquid-Chromatography (HPLC). A comparison with results reported in the literature shows that in patients without meningitis there is markedly lower concentration of chloramphenicol in the CSF than expected, i.e. it penetrates the "blood-brain" barrier much less easily.
mesh_terms: D002701:Chloramphenicol / Q000097:blood / Q000134:cerebrospinal fluid*; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D008581:Meningitis / Q000134:cerebrospinal fluid
chemical_list: D002701:Chloramphenicol
vernacular_title: Liquorgängigkeit von Chloramphenicol--eine kritische Uberprüfung.