Liver-cell tumours in rats fed hexachlorobenzene.
All animals in a group of female Agus rats fed 100 ppm of hexachlorobenzene (HCB) in their diet for up to 90 weeks developed multiple liver-cell tumours whereas none were seen in control rats. There was no evidence of skin lesions or nervous symptoms usually seen with higher doses of HCB. A high incidence of liver-cell tumours was also seen with MRC Wistar female rats fed HCB for 75 weeks.
D000818:Animals; D001835:Body Weight; D002722:Chlorobenzenes / Q000009:adverse effects*; D004435:Eating; D005260:Female; D006581:Hexachlorobenzene / Q000008:administration & dosage / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000139:chemically induced*; D009374:Neoplasms, Experimental / Q000139:chemically induced; D051381:Rats
D002722:Chlorobenzenes; D006581:Hexachlorobenzene