Failure of lidocaine in vivo to inhibit mitogen-induced lymphocyte transformation.
Lidocaine in vitro has been reported not to inhibit phytohaemagglutinin (PHA)-induced lymphocyte responses at clinically applicable concentrations. The present study failed also to show any in vivo effect of lidocaine on the PHA- and concanavalin A-induced lymphocytic responses.
D000328:Adult; D003208:Concanavalin A / Q000494:pharmacology; D006801:Humans; D008012:Lidocaine / Q000097:blood / Q000494:pharmacology*; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010835:Phytohemagglutinins / Q000494:pharmacology*; D013997:Time Factors
D010835:Phytohemagglutinins; D003208:Concanavalin A; D008012:Lidocaine