Potentiation of noise-induced audiogenic seizure risk by salicylate in mice as a function of salicylate-noise exposure interval.
Audiogenic seizure risk can be induced in genetically seizure-resistant BALB/c mice by exposure to an intense noise. Results of this experiment showed that combined exposure to noise and sodium salicylate could produce a greater priming effect than exposure to the noise alone, and the greatest potentiation effect was obtained when animals were exposed to the noise 6 hr after the intake of salicylate. The findings were taken as indirect evidence suggesting that the ototoxic action of sodium salicylate could potentiate vulnerability of the mouse cochlea to noise damage.
D000161:Acoustic Stimulation; D000818:Animals; D006317:Hearing Loss, Noise-Induced / Q000209:etiology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009622:Noise / Q000009:adverse effects*; D012640:Seizures / Q000139:chemically induced* / Q000209:etiology; D012980:Sodium Salicylate / Q000494:pharmacology*; D013997:Time Factors
D012980:Sodium Salicylate