title: [Comparative study of the estrogenic, antifertility and antigonadotropic effects of modified estrogens].
abstract: Estrogen (in uterotropic test on sexually immature female rats), antifertile (in experiments on sexually mature pregnant female rats), and antigonadotropic (in a test on sexually immature male rats) properties of some 2- and 4-bromine and silylsubstituted estradiols were compared in oral administration. 4-silylestradiols expressed marked antigonadotropic effects equal by activity to mestranol standard, and reduced as compared with the standard antifertile and estrogenic properties. 2- and 4-bromide and 2-silylestradiols were weakly active or inactive oral estrogens and possessed no antifertile properties.
mesh_terms: D000818:Animals; D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D004353:Drug Evaluation, Preclinical; D010064:Embryo Implantation / Q000187:drug effects; D045166:Estradiol Congeners / Q000494:pharmacology*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects*; D008297:Male; D011247:Pregnancy; D051381:Rats; D013737:Testis / Q000187:drug effects*; D014599:Uterus / Q000187:drug effects
chemical_list: D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal; D045166:Estradiol Congeners
vernacular_title: Sravnnitel'noe izuchenie éstrogennogo, antifertil'nogo i antigonadotropnogo éffektov nekotorykh modifitsirovannykh éstrogenov.