title: Therapy of anorectal gonorrhea in men. Efficacy of oral antibiotic regimens.
abstract: The results of therapy in 916 men with anorectal gonorrhea treated with orally given antibiotic drugs were reviewed retrospectively. There was a 17.8 percent failure rate for tetracycline (total dose, 10 grams) and a 10.7 percent failure for 3.5 grams of ampicillin plus 1 gram of probenicid. Repeating the ampicillin plus probenicid dose once in 8 to 14 hours reduced the failure rate to 1.6 percent, an efficacy comparable to the regimen of 4.8 million units of aqueous procaine penicillin G given intramuscularly plus 1 gram of probenicid given orally for treatment of anorectal gonorrhea.
mesh_terms: D000284:Administration, Oral; D000667:Ampicillin / Q000008:administration & dosage* / Q000627:therapeutic use; D004338:Drug Combinations; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011339:Probenecid / Q000008:administration & dosage* / Q000627:therapeutic use; D012002:Rectal Diseases / Q000188:drug therapy*; D012189:Retrospective Studies; D013752:Tetracycline / Q000008:administration & dosage* / Q000627:therapeutic use
chemical_list: D004338:Drug Combinations; D000667:Ampicillin; D013752:Tetracycline; D011339:Probenecid