Conformational study of [Leu5]-enkephalin by laser Raman spectroscopy.
The Raman spectrum of [Leu5]-enkephalin in the solid state indicates the presence of a type I' beta bend, in agreement with X-ray data of Smith & Griffin (1978). In solution, this molecule takes on different conformations in different solvents. In DMSO-d6, it forms a beta-bend structure whereas in water it exists as an ensemble of conformations.
D004121:Dimethyl Sulfoxide; D004723:Endorphins; D004743:Enkephalin, Leucine; D004745:Enkephalins; D011487:Protein Conformation; D012997:Solvents; D013055:Spectrophotometry, Infrared; D013059:Spectrum Analysis, Raman; D014867:Water; D014961:X-Ray Diffraction
D004723:Endorphins; D004745:Enkephalins; D012997:Solvents; D014867:Water; D004743:Enkephalin, Leucine; D004121:Dimethyl Sulfoxide