Immunoreactive human calcitonin-like molecule in the nervous systems of protochordates and a cyclostome, Myxine.
A molecule very closely resembling human calcitonin immunologically and chromatographically was extracted from the nervous systems of several protochordates and a cyclostome, Myxine. The presence of human calcitonin-like molecules in the nervous systems of primitive chordates suggests that they have some function in the nervous system of these species and that the bone-regulating function of the calcitonins may have arisen much later in the vertebrates.
D000818:Animals; D001923:Brain Chemistry; D002116:Calcitonin / Q000032:analysis*; D002816:Chordata, Nonvertebrate / Q000032:analysis*; D002850:Chromatography, Gel; D002851:Chromatography, High Pressure Liquid; D005399:Fishes / Q000378:metabolism*; D009420:Nervous System / Q000032:analysis*; D011863:Radioimmunoassay; D014561:Urochordata / Q000032:analysis*
D002116:Calcitonin