Antihypertensive 5,6-diarylpyridazin-3-ones.
The synthesis of a series of 5,6-diarylpyridazinones is described. Some members of this series display an antihypertensive effect in both the spontaneously hypertensive rat (SHR) model and the deoxycorticosteroid (DOCA) model of hypertension. The most potent compounds in the series have halogen substituents on the 5,6-diphenyl rings, a beta-substituted alkyl group at the 2 position of the ring, and acetyl or cyano substituent at the 4 position.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D003900:Desoxycorticosterone; D006973:Hypertension / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D011724:Pyridazines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
D000959:Antihypertensive Agents; D011724:Pyridazines; D003900:Desoxycorticosterone