Effects of acetaldehyde on the membrane potential and membrane resistance of the identified neurons in the abdominal ganglion of Aplysia kurodai.
Actions of acetaldehyde on membrane potentials and membrane resistances of Aplysia neurons were studied using an intracellular recording and current injection technique. Several functionally different neurons in the abdominal ganglion of A. kurodai were identified on the basis of their morphological and electrophysiological characteristics. Application of between 5 and 50 mM acetaldehyde produced depolarization of the membrane, in all types of cells investigated. This depolarization was accompanied by an increase in the rate of spike discharge. The amplitude and the rates of rise and fall of the action potential were reduced and the duration of the spike was prolonged. Acetaldehyde had no significant effect on the input resistances of ganglion cells. These actions of the aldehyde were observed to be similar in the completely isolated neuron-soma preparation separated from the neighbouring cells or synapses.
D000079:Acetaldehyde / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001048:Aplysia; D004594:Electrophysiology; D005724:Ganglia / Q000166:cytology*; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000187:drug effects* / Q000502:physiology
D000079:Acetaldehyde