title: [Haemodilution and duration of action of muscle relaxants (author's transl)].
abstract: As indicated by time-effect diagrams the duration of action of the ED90 of succinylcholine (0.3 mg/kg), pancuronium (0.033 mg/kg), and tubocurarine (0.21 mg/kg) was prolonged following preoperative normovolemic haemodilution. This influence is assumed to be due to a lower protein binding and cholinesterase activity, to an increase of cardiac output and muscle perfusion and to a higher occupancy of the receptor at the motor endplate by muscle relaxants.
mesh_terms: D002302:Cardiac Output; D006438:Hemodilution; D006801:Humans; D009045:Motor Endplate; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D010197:Pancuronium / Q000494:pharmacology*; D011485:Protein Binding; D013390:Succinylcholine / Q000494:pharmacology*; D014403:Tubocurarine / Q000494:pharmacology*
chemical_list: D013390:Succinylcholine; D010197:Pancuronium; D014403:Tubocurarine
vernacular_title: Hämodilution und Wirkungsdauer von Muskelrelaxantien.