[Role of the mesencephalon reticular formation in the effect of ethosuximide on a cortical epileptogenic focus].
Ethosuximide provoked in encéphale isolé cats a dose-dependent suppression or facilitation of strychnine focus spiking activity, and in combination with high frequency stimulation of formatio reticularis mesencephali a significant activation of the cortical focus. The results seem to show that the influence of ethosuximide on the formatio reticularis mesencephali is one--if not the main--component of the drug effect.
D000200:Action Potentials; D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000187:drug effects* / Q000502:physiology; D003655:Decerebrate State; D004569:Electroencephalography; D005013:Ethosuximide / Q000494:pharmacology*; D005260:Female; D008297:Male; D051381:Rats; D012154:Reticular Formation / Q000187:drug effects* / Q000502:physiology; D012640:Seizures / Q000139:chemically induced*; D013331:Strychnine
D005013:Ethosuximide; D013331:Strychnine
Zur Rolle der mesenzephalen retikulären Formation bei der Wirkung von Ethosuximid auf den kortikalen epileptogenen Herd.