A study of the debrisoquine hydroxylation polymorphism in a Nigerian population.
1. The metabolic oxidation of debrisoquine has been studied in a group of 123 Nigerian volunteers. 2. All subjects excreted unchanged drug together with five oxidation products, namely, 4-, 5-, 6-, 7- and 8-hydroxy-debrisoquine. 3. The 4-hydroxylation reaction exhibits polymorphism; ten subjects were defective in their ability to effect this reaction. 4. The incidence (q) of the allele governing impaired 4-hydroxylation (DL) among Nigerians was calculated as being 0.28 (95% confidence limit of 0.20-0.37). 5. An association was demonstrated between the ability to effect 4-hydroxylation and 6- and 7-hydroxylation of debrisoquine, suggesting that the alleles controlling alicyclic oxidation also influence aromatic hydroxylation.
D000293:Adolescent; D000328:Adult; D000483:Alleles; D003647:Debrisoquin / Q000652:urine*; D005260:Female; D005828:Genetics, Population; D006801:Humans; D006900:Hydroxylation; D007546:Isoquinolines / Q000652:urine*; D008297:Male; D009549:Nigeria; D011110:Polymorphism, Genetic
D007546:Isoquinolines; D003647:Debrisoquin