title: [Pharmacokinetic model studies of sulfamerazine in domestic mammals. 4. Mebacid tablet and Mebacid 200 dosage calculation problems].
abstract: The highly variegated complex of aspects relating to dosage calculation for veterinary drugs is explained and discussed by examples of Mebacid 200 and Mebacid tablets. For domestic mammals, a dosage interval of 24 hours is desirable for reasons of economy. Therefore, due allowance must be made, by means of unilateral confidence, of the most unfavourable case of high protein fixation, low half-life for elimination, and high coefficient of distribution. The following equation, proposed by DETTLI and SPRING (1966) was used for dosage calculation: AD = c . delta' . ek2 . t or ED = c . delta' . (ek2 . t -1) The dosage will now be in a twelve-hour rhythm, because of the low half-life for elimination of sulphamerazine-Na. A pharmacokinetically founded dosage interval of 24 hours will be feasible only by oral application of Mebacid tablets. The difference between the calculated initial and maintenance doses was found to be negligible.
mesh_terms: D000818:Animals; D000829:Animals, Domestic; D007273:Injections, Intramuscular / Q000662:veterinary; D007275:Injections, Intravenous / Q000662:veterinary; D007279:Injections, Subcutaneous / Q000662:veterinary; D008322:Mammals / Q000378:metabolism; D008954:Models, Biological; D013045:Species Specificity; D013416:Sulfamerazine / Q000008:administration & dosage* / Q000378:metabolism; D013607:Tablets
chemical_list: D013607:Tablets; D013416:Sulfamerazine
vernacular_title: Pharmakokinetische Modelluntersuchungen an Sulfamerazin bei Haussäugetieren. 4. Mitteilung: Zur Problematik von Dosisberechnungen an Mebacid-Tabletten und Mebacid 200.