Malignant lymphoma and exposure to chemicals, especially organic solvents, chlorophenols and phenoxy acids: a case-control study.
A number of men with malignant lymphoma of the histiocytic type and previous exposure to phenoxy acids or chlorophenols were observed and reported in 1979. A matched case-control study has therefore been performed with cases of malignant lymphoma (Hodgkin's disease and non-Hodgkin lymphoma). This study included 169 cases and 338 controls. The results indicate that exposure to phenoxy acids, chlorophenols, and organic solvents may be a causative factor in malignant lymphoma. Combined exposure of these chemicals seemed to increase the risk. Exposure to various other agents was not obviously different in cases and in controls.
D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000009:adverse effects; D008456:2-Methyl-4-chlorophenoxyacetic Acid / Q000009:adverse effects; D000328:Adult; D000368:Aged; D001554:Benzene / Q000009:adverse effects; D002733:Chlorophenols / Q000009:adverse effects*; D006016:Glycolates / Q000009:adverse effects*; D006689:Hodgkin Disease / Q000139:chemically induced; D006801:Humans; D008223:Lymphoma / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced*; D012997:Solvents / Q000009:adverse effects*; D013343:Styrenes / Q000009:adverse effects; D014241:Trichloroethylene / Q000009:adverse effects
D002733:Chlorophenols; D006016:Glycolates; D012997:Solvents; D013343:Styrenes; D014241:Trichloroethylene; D015085:2,4,5-Trichlorophenoxyacetic Acid; D008456:2-Methyl-4-chlorophenoxyacetic Acid; D001554:Benzene