Morphology of the neoplasms of the thyroid gland in Fischer 344 rats treated with 4,4'-methylene-bis-(N,N-dimethyl)-benzenamine.
Follicular neoplasms of the thyroid gland developed in 79 of 200 Fischer 344 rats of both sexes, fed either 0.0375% or 0.075% 4,4'-methylene-bis-(N,N-dimethyl)-benzenamine (MDBA) mixed with the diet. Hyperplastic changes in the follicular epithelium occurred in 12 rats fed the higher concentration of this chemical. One of 40 control rats had a follicular carcinoma of the thyroid gland.
D000230:Adenocarcinoma / Q000139:chemically induced / Q000473:pathology*; D000814:Aniline Compounds / Q000633:toxicity*; D000818:Animals; D001559:Benzhydryl Compounds / Q000633:toxicity*; D005260:Female; D006965:Hyperplasia; D008297:Male; D009374:Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D010911:Pituitary Neoplasms / Q000139:chemically induced; D051381:Rats; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000139:chemically induced / Q000473:pathology*
D000814:Aniline Compounds; D001559:Benzhydryl Compounds; C035472:N,N,N',N'-tetramethyl-4,4'-methylenedianiline