[Effect of complamine, nonachlazine, riboxine and clofeline on the fibrinogen content and fibrinolytic activity of the blood].
Single intravenous administration of complamin and riboxin (10 mg/kg) and nonachlazin (7 mg/kg) to white rats of both sexes activates fibrinolysis. Single intravenous administration of clofelin in a dose of 30 micrograms/kg does not exert any effect on this proteolytic process. Chronic experiments on animals given clofelin (50 micrograms/kg) and riboxin (15 mg/kg) intramuscularly or nonachlazin (20 mg/kg) per os showed that blood fibrinolytic activity drops down. Concurrently the fibrinogen titer is increased. Prolonged intramuscular administration of complamin in a dose of 15 mg/kg activates fibrinolysis in rats and decreases fibrinogen concentration.
D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D005342:Fibrinolysis / Q000187:drug effects*; D007273:Injections, Intramuscular; D007275:Injections, Intravenous; D007290:Inosine Diphosphate / Q000494:pharmacology*; D007292:Inosine Nucleotides / Q000494:pharmacology*; D008297:Male; D009628:Nonachlazine / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology*; D051381:Rats; D013806:Theophylline / Q000031:analogs & derivatives*; D013997:Time Factors; D014971:Xanthinol Niacinate / Q000494:pharmacology*
D007292:Inosine Nucleotides; D010640:Phenothiazines; D009628:Nonachlazine; D007290:Inosine Diphosphate; D014971:Xanthinol Niacinate; D005340:Fibrinogen; D013806:Theophylline; D003000:Clonidine
Izuchenie vliianiia komplamina, nonakhlazina, riboksia i klofelina na soderzhanie fibrinogena i fibrinoliticheskuiu aktivnost' krovi.