A critical study on the preparation and application of gelatin-resorcinol tissue adhesive crosslinked by formaldehyde.
A tissue adhesive composed of gelatin-resorcinol-formaldehyde was prepared. The factors, influencing its properties were discussed and compared with other preparation methods. Incised rat skin wounds were unified with adhesive applied between the wound edges or on the wound surface. Sutured skin wounds served as controls. After a week, the skin wounds with adhesive on their surface had a tensile strength twice as much as the sutured wounds. The granulation tissue was narrow, scarcely was inflammation reaction, no formaldehyde necrosis occurred.
D000818:Animals; D004338:Drug Combinations / Q000627:therapeutic use; D005557:Formaldehyde / Q000627:therapeutic use*; D005780:Gelatin / Q000627:therapeutic use*; D006097:Granulation Tissue / Q000473:pathology; D008297:Male; D051381:Rats; D012118:Resorcinols / Q000627:therapeutic use*; D013718:Tensile Strength; D014014:Tissue Adhesives; D014945:Wound Healing
D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin