Inhibition of experimental bladder tumor induction by systemic BCG treatment.
Transitional cell carcinoma of the urinary bladder was induced in rats by ingestion of 0.188% N-[4-5-nitro-2-furyl)-2-thiazolyl] formamide. During the induction period of 8 months, one animal group received systemic BCG treatment. After 12 months, the BCG-treated rats showed a significantly lower bladder tumor weight and stage than the corresponding controls. The results are discussed with regard to the possibility of BCG prophylaxis of human bladder tumors.
D000818:Animals; D001500:BCG Vaccine / Q000627:therapeutic use*; D001835:Body Weight; D002295:Carcinoma, Transitional Cell / Q000473:pathology / Q000517:prevention & control*; D005260:Female; D007682:Kidney Pelvis / Q000473:pathology; D009367:Neoplasm Staging; D009374:Neoplasms, Experimental / Q000473:pathology / Q000517:prevention & control; D009929:Organ Size; D051381:Rats; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000517:prevention & control*
D001500:BCG Vaccine