[Medicamentous enzyme induction and hormonal contraception. First communication: effects of anti-epileptics on hormonal contraception of epileptics (author's transl)].
Studies were conducted into the effects of anti-epileptics on hormonal contraception of epileptics, with reference being primarily made to biochemical as well as clinicoexperimental findings regarding medication and its effects, through the mechanism of medicamentous enzyme induction, on biological transformation of steroid hormones. Disorders of bleeding, the most sensitive symptom of enzyme induction, occurred more often than they did in a control group, the difference in occurrence being secured with significance. Contraceptive protection of those patients was equally reduced. Conclusions were drawn for contraceptive practice.
D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D003276:Contraceptives, Oral / Q000494:pharmacology*; D003278:Contraceptives, Oral, Hormonal / Q000009:adverse effects / Q000494:pharmacology*; D004347:Drug Interactions; D004790:Enzyme Induction / Q000187:drug effects; D004827:Epilepsy / Q000188:drug therapy* / Q000201:enzymology; D005260:Female; D006801:Humans; D008599:Menstruation Disturbances / Q000139:chemically induced*
D000927:Anticonvulsants; D003276:Contraceptives, Oral; D003278:Contraceptives, Oral, Hormonal
Medikamentöse Enzyminduktion und hormonale Kontrazeption. 1. Mitteilung: Einfluss von Antiepileptika auf die hormonale Kontrazeption bei Epileptikerinnen.