title: Recovery of choline acetyltransferase activity in the rat urinary bladder deprived of half of the innervation.
abstract: In the urinary bladder of the rat, partially denervated by unilateral removal of the pelvic ganglion 3 days in advance, the activity of the acetylcholine-forming enzyme, choline acetyltransferase, measured by a radiolabelling method, was reduced to 58% of the control. A gain in enzyme activity of 28% was found to have occurred when the bladders were examined 25 days postoperatively; the main part of this increase took place during the period 3 to 6 days after the operation and beyond 25 days no further gain in enzyme activity was found. The present findings are compared with previous observations of a transient supersensitivity and an increased motor response to electrical stimulation of the intact pelvic nerve of such a partially denervated bladder.
mesh_terms: D000818:Animals; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D003714:Denervation; D008297:Male; D009929:Organ Size; D051381:Rats; D013997:Time Factors; D001743:Urinary Bladder / Q000201:enzymology / Q000294:innervation* / Q000502:physiology
chemical_list: D002795:Choline O-Acetyltransferase