Congenital anophthalmia associated with intracranial germinoma.
A 14-year-old boy with anophthalmia presented evidence of hypothalamic dysfunction. He was found to have a third-ventricular germinoma, probably pineal. This case is interesting in view of a previous case report of the association of anophthalmia and a germ-cell tumor (teratoma), and suggests a possible causal relationship between this malformation and germ-cell neoplasms, bith of which probably arise early in development.
D000293:Adolescent; D000853:Anophthalmos / Q000150:complications*; D002551:Cerebral Ventricle Neoplasms / Q000150:complications* / Q000175:diagnosis; D004407:Dysgerminoma / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D008297:Male