title: Interaction of phenylbutazone and tolbutamide in man.
abstract: Phenylbutazone pretreatment increases tolbutamide half-life, whereas tolbutamide pretreatment decreases phenylbutazone half-life in man. Clinically, phenylbutazone may enhance the hypoglycemic action of tolbutamide, and tolbutamide may reduce the therapeutic effect of phenylbutazone.
mesh_terms: D000328:Adult; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D008875:Middle Aged; D010653:Phenylbutazone / Q000378:metabolism* / Q000494:pharmacology; D014044:Tolbutamide / Q000378:metabolism* / Q000494:pharmacology
chemical_list: D014044:Tolbutamide; D010653:Phenylbutazone