Effect of pyran copolymer on murine hemopoiesis.
Pyran Copolymer (NSC-46015), a divinyl-ether maleic anhydride leads to a significant shift in distribution of nucleated cells and CFUs in the bone marrow and spleen. The bone marrow cellularity and the CFUs content reach a nadir 4 to 6 days after Pyran injection, simultaneous rise in spleen cellularity and CFUs concentration of circulating pluripotent stem cells by a factor of 10 to 45 and a concomitant rise of CFUc is seen. the origin of the mobilized pluripotent stem cells is likely to be the bone marrow, not athe spleen.
D000818:Animals; D002452:Cell Count; D003114:Colony-Forming Units Assay; D006410:Hematopoiesis / Q000187:drug effects*; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D011108:Polymers / Q000494:pharmacology*; D011713:Pyran Copolymer / Q000494:pharmacology*; D013154:Spleen / Q000166:cytology; D013156:Splenectomy
D011108:Polymers; D011713:Pyran Copolymer