Mechanism of the development of resistance to mitomycin C in Hirosaki sarcoma.
In the peritoneal cavity of the rat, Hirosaki sarcoma, as ascites tumor of the rat, acquired a resistance to the essentially effective dose of 100 microgram/kg of mitomycin C by means of the daily treatment with the ineffective dose of 10 or 1 microgram/kg of mitomycin C. It is considered that most of Hirosaki sarcoma cells may have gradually acquired a hereditary resistance to mitomycin C in the course of the contact with the drug.
D000818:Animals; D004351:Drug Resistance; D005260:Female; D008297:Male; D008937:Mitomycins / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D012513:Sarcoma, Experimental / Q000188:drug therapy*
D008937:Mitomycins