title: Ataxia-telangiectasia and xeroderma pigmentosum: no evidence of linkage to HLA.
abstract: Nine HLA-typed multiplex nuclear families segregating ataxia-telangiectasia (A-T), an autosomal recessive disorder, were studied. Linkage analysis performed by lod scores and by a previously published sib pair method revealed no evidence for linkage between A-T and HLA. An alternative method of linkage detection, previously applied to xeroderma pigmentosum (XP) and HLA, was reexamined and found to contain an error. As a consequence, neither of these "DNA repair disorders" appears to be linked to HLA.
mesh_terms: D001260:Ataxia Telangiectasia / Q000235:genetics* / Q000276:immunology; D008040:Genetic Linkage; D006680:HLA Antigens / Q000235:genetics*; D006801:Humans; D008126:Lod Score; D014983:Xeroderma Pigmentosum / Q000235:genetics* / Q000276:immunology
chemical_list: D006680:HLA Antigens