Effect of DOCA-saline treatment on calcium metabolism in the rat.
This study aims to investigate changes in the calcium balance in DOCA-saline treated rats and the effect of parathyroidectomy on these changes during such treatment. However, even with this large loss in calcium, the calcium balance was higher after 2 weeks of treatment than in normal untreated rats. The DOCA-saline treatment provoked greater in normal rats. But the calcium balance became negative after 2 weeks of treatment. Thus, it appears that the presence of the parathyroid gland is necessary to provoke a gain in the calcium balance during mineralocorticoid treatment.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003900:Desoxycorticosterone / Q000494:pharmacology*; D004231:Diuresis / Q000187:drug effects; D005243:Feces / Q000032:analysis; D008297:Male; D010280:Parathyroid Glands / Q000502:physiology; D051381:Rats; D012965:Sodium Chloride / Q000494:pharmacology*
D003900:Desoxycorticosterone; D012965:Sodium Chloride; D002118:Calcium