[Antiexudative effect of naringin in experimental pulmonary edema and peritonitis].
The authors examined antiexudative activity of bioflavonoids naringin and rutin in comparative aspect in two models of acute inflammation. The experiments were carried out on 180 male white rats and 24 guinea pigs. The two flavonoids manifested marked antiexudative effect in rats with experiments peritonitis, induced by the model of U. M. Teotino et al. ED50 of naringin was 200 mg per kg after oral administration, but of rutin-260 mg per kg. In the same model ED50 of naringin was 67 mg per kg of body weight after intramuscular administration. In rats and guinea pigs with experimental lung oedema naringin, used in a dose of 200 mg per kg intraperitoneally two hours before injection of edemogenous substance (a water solution of ammonium chloride), reduced lethality with 57,4% in rats and with 37% in guinea pigs, but rutin-with 50% and 25% respectively. The examined substances were used in doses, presenting 10% of DL50. There was no statistically significant difference in respect to their antiexudative activity.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D044950:Flavanones; D005419:Flavonoids / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010538:Peritonitis / Q000188:drug therapy*; D011654:Pulmonary Edema / Q000188:drug therapy*; D051381:Rats; D012431:Rutin / Q000008:administration & dosage / Q000627:therapeutic use
D044950:Flavanones; D005419:Flavonoids; D012431:Rutin; C005274:naringin
Antieksudativen efekt na naringina pri eksperimentalen belodroben otok i peritonit.