Metabolic studies on pentachloronitrobenzene (PCNB) in rats.
The metabolism of PCNB in rats was studied. Metabolites isolated from rat excreta and identified were: N-acetyl-S-(pentachlorophenyl)cysteine, pentachlorothiophenol, pentachlorothioanisole, 2,3,4,5-tetrachlorothiophenol, 2,3,4,5-tetrachlorothioanisole, 2,3,4,6- and/or 2,3,5,6-tetrachloro-thiophenol and -thioanisole, 1,4-bis(methylthio)tetrachlorobenzene, 1,4-dimercapto-tetrachlorobenzene and/or 4-methylthio-tetrachlorothiophenol, pentachlorophenol, pentachloroanisole, 2,3,4,5-tetrachlorophenol, 2,3,4,5-tetrachloroanisole, 2,3,4,6- and/or 2,3,5,6-tetrachloro-phenol and -anisole, pentachlorobenzene, 2,3,4,5-tetrachloronitrobenzene, pentachloroaniline and 2,3,4,5-tetrachloroaniline.
D000042:Absorption; D000111:Acetylcysteine / Q000031:analogs & derivatives / Q000652:urine; D000814:Aniline Compounds / Q000302:isolation & purification; D000818:Animals; D002722:Chlorobenzenes / Q000378:metabolism* / Q000652:urine; D002849:Chromatography, Gas; D002855:Chromatography, Thin Layer; D003545:Cysteine; D005243:Feces / Q000032:analysis; D005260:Female; D005659:Fungicides, Industrial / Q000378:metabolism* / Q000652:urine; D006581:Hexachlorobenzene / Q000378:metabolism; D008297:Male; D013058:Mass Spectrometry; D009578:Nitrobenzenes / Q000378:metabolism* / Q000652:urine; D051381:Rats
D000814:Aniline Compounds; D002722:Chlorobenzenes; D005659:Fungicides, Industrial; D009578:Nitrobenzenes; D006581:Hexachlorobenzene; C027672:pentachlorophenylmercapturic acid; D003545:Cysteine; C005805:quintozene; C027673:2,3,4,5,6-pentachloroaniline; D000111:Acetylcysteine