Variations in the phenotypic expression of an H-2-linked gene contributing to the control of IgE and haemagglutinating antibody responses to ovalbumin.
The genetic control of IgE- and HA-antibody responses to ovalbumin (OV) was investigated in H and L antibody responder lines of mice and in their hybrids. After immunization with threshold doses of OV (0.5 and 0.05 microgram OV) H mice were responder in terms of both HA and IgE antibody whereas L mice were non-responder. This trait was under monogenic control and the relevant gene was H-2-linked. The dominance direction depended on the antigen dose since high response was dominant for 0.5 microgram and recessive for 0.05 microgram. After immunization with a higher dose (10 microgram OV), the intervention of non-H-2 genes in the genetic control of the antibody response becomes manifest. The quantitative effect of the H-2 locus was greater for IgE- than for HA-antibody response, suggesting a less complex genetic control at the IgE-antibody level.
D000818:Animals; D002874:Chromosome Mapping; D004306:Dose-Response Relationship, Immunologic; D005260:Female; D008040:Genetic Linkage; D006183:H-2 Antigens / Q000235:genetics*; D006388:Hemagglutinins / Q000235:genetics*; D007073:Immunoglobulin E / Q000096:biosynthesis* / Q000235:genetics; D007700:Kinetics; D008297:Male; D051379:Mice; D010047:Ovalbumin / Q000276:immunology; D010641:Phenotype; D012756:Sheep
D006183:H-2 Antigens; D006388:Hemagglutinins; D007073:Immunoglobulin E; D010047:Ovalbumin