[Microbiological dosage of the antitumoral drugs (author's transl)].
The AA. give a complete list of now available microbiological methods to titrate chemo-cytostatic drugs in organic fluids. The described techniques are of particular interest for many reasons: they are easy, inexpensive and rapid; they are reproducible, very sensible and specific. The latter quality privileges the microbiological test in comparison with RIA methods. The introduction into clinical practice of chemotherapy routine monitoring will improve the handling of so active drugs as cytostatics and, toward a more rational treatment of the patients and a better definition of individual minimum active doses.
D000818:Animals; D000970:Antineoplastic Agents / Q000032:analysis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D001681:Biological Assay / Q000379:methods*; D001826:Body Fluids / Q000032:analysis; D003561:Cytarabine / Q000032:analysis; D003630:Daunorubicin / Q000032:analysis; D004317:Doxorubicin / Q000032:analysis; D006801:Humans; D008727:Methotrexate / Q000032:analysis; D051381:Rats
D000970:Antineoplastic Agents; D003561:Cytarabine; D004317:Doxorubicin; D008727:Methotrexate; D003630:Daunorubicin
Il dosaggio microbiologico dei farmaci antitumorali.