Possible in vivo formation of a carcinogenic substance from diethyl pyrocarbonate and ammonia.
Development of lung tumors can be observed in Kid: CFLP mice treated intragastrically with diethyl pyrocarbonate and ammonia. The lung tumors may result from a carcinogenic substance, supposedly urethane, formed in vivo from diethyl pyrocarbonate in the presence of ammonia.
D000641:Ammonia / Q000009:adverse effects*; D000818:Animals; D004047:Diethyl Pyrocarbonate / Q000009:adverse effects*; D005260:Female; D005561:Formates / Q000009:adverse effects*; D008175:Lung Neoplasms / Q000139:chemically induced*; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D014520:Urethane / Q000138:chemical synthesis
D005561:Formates; D014520:Urethane; D000641:Ammonia; D004047:Diethyl Pyrocarbonate