title: [Different concentrations of drugs in respiratory and skeleton muscles in cases of lethal poisonings (author's transl)].
abstract: The quantitative distribution of drugs in seven cases of intoxication has been investigated especially in different muscles distinguished by their functions. The analyses have been verified in two respiratory muscles (m. intercostalis and diaphragma) and two skeletal muscles, being inactive during unconsciousness (m. psoas major and m. quadriceps). In all cases, higher concentrations of drugs have been found in the respiratory muscles than in the skeletal muscles. During the acute phase of intoxication an enhanced quantity of drugs is stored in the active respiratory muscles. The skeletal muscle shows reduced metabolism activities with lowered storage of drugs.
mesh_terms: D003964:Diaphragm / Q000378:metabolism; D006801:Humans; D006993:Hypnotics and Sedatives / Q000378:metabolism / Q000506:poisoning*; D007366:Intercostal Muscles / Q000378:metabolism; D009130:Muscle, Smooth / Q000378:metabolism*; D009132:Muscles / Q000378:metabolism*
chemical_list: D006993:Hypnotics and Sedatives
vernacular_title: Unterschiedliche Konzentrationen von Schlafmitteln in Atem- und Skelettmuskulatur bei tödlichen Vergiftungen.