[Effect of nonachlazine on ino- and chronotropic function].
As a result of the stimulation of beta-adrenostructures of the myocardium nonachlazin intensifies ino- and chronotropic functions of the heart. This effect does not manifest after administration of practolol and is less pronounced in animals anesthesized with urethane and alpha-chloralose since the sensitivity of the beta-adrenostructures of the myocardium decreases under the influence of the anesthetics. Apart from the stimulation of ino- and chronotropic function of the heart nonachlazin reduces concurrently the intensity of positive chronotropic effect of isoproterenol. Such a combination of the efects called a "partial" beta-adrenoblockade seems likely to play an important role in the manifestation of the antianginal action of nonachlazin.
D000758:Anesthesia; D000818:Animals; D002415:Cats; D004562:Electrocardiography; D055590:Electromagnetic Phenomena; D006339:Heart Rate / Q000187:drug effects*; D009200:Myocardial Contraction / Q000187:drug effects*; D009628:Nonachlazine / Q000494:pharmacology*; D010640:Phenothiazines / Q000494:pharmacology*; D014851:Wakefulness / Q000187:drug effects
D010640:Phenothiazines; D009628:Nonachlazine
Vliianie nonakhlazina na ino- i khronotropnuiu funktsiiu.