title: Canine parvovirus infection in South American canids.
abstract: Canine parvovirus (CPV) infections occurred in 5 of 35 South American canids at the Department of Conservation (DC), a breeding facility of the National Zoological Park in Front Royal, Va. The clinical signs were anorexia, lethargy, diarrhea, and vomiting. Three of the affected canids survived and had high hemagglutination-inhibition titers to CPV in the recovery period. Necropsy of the 2 that died revealed extensive necrosis of the intestinal mucosa; CPV particles were observed by electron microscopy in the intestinal contents of both animals. Six of the 30 canids that remained healthy had high hemagglutination-inhibition titers to CPV prior to the episode of illness, indicating earlier subclinical exposure. Pet dogs belonging to DC personnel that were screened as a possible source of the infection had no evidence of disease. All canids (including pet dogs) on the DC grounds were vaccinated repeatedly with a killed feline panleukopenia virus product after the episode, with little or no effect on existing titers.
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D000914:Antibodies, Viral / Q000032:analysis; D002335:Carnivora / Q000276:immunology; D004285:Dogs / Q000276:immunology; D005589:Foxes / Q000276:immunology; D010321:Parvoviridae / Q000276:immunology; D013020:South America; D014611:Vaccination / Q000662:veterinary; D014777:Virus Diseases / Q000276:immunology / Q000473:pathology / Q000662:veterinary*
chemical_list: D000914:Antibodies, Viral