Repair of the ultraviolet-irradiated male genome in fertilized mouse eggs.
Unscheduled DNA synthesis occurred in both male and female pronuclei of the mouse zygote in response to irradiation with ultraviolet light, indicating a capacity for excision repair. Furthermore, damage to DNA of the male gamete before fertilization can be repaired after the sperm enters the egg cytoplasm.
D000818:Animals; D001345:Autoradiography; D003593:Cytoplasm / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis / Q000528:radiation effects; D004260:DNA Repair; D005260:Female; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013094:Spermatozoa / Q000528:radiation effects*; D014466:Ultraviolet Rays; D015053:Zygote / Q000378:metabolism* / Q000528:radiation effects
D004247:DNA