Sodium 2-chloropropionate: its effects on experimental hyperlactatemia in the dog.
The effects of sodium 2-chloropropionate (2-CP), an activator of pyruvate dehydrogenase were studied on normal dogs. Two sets of experiments were performed: 1) 2-CP was administered to conscious dogs by gastric intubation at 1.16 mmol/kg b.wt. The drug induced a decrease in blood lactate and pyruvate levels but did not produce any significant change in blood glucose, blood beta-hydroxybutyrate or acetoacetate levels. 2) 2-CP given i.v. (1.16 mmol/kg b.wt. during 20 min) rapidly reduced the experimental hyperlactatemia induced by continuous infusion of epinephrine (1.5 microgram/kg . min) or fructose (0.5 g/kg . hr). Considering the metabolic side effects induced by dichloroacetate, another activator of pyruvate dehydrogenase, we suggest that use of 2-CP rather than dichloroacetate might be of interest, particularly in the treatment of hyperlactatemia or lactic acidosis.
D000758:Anesthesia; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004285:Dogs; D004837:Epinephrine / Q000494:pharmacology; D005632:Fructose / Q000494:pharmacology; D006843:Hydrocarbons, Chlorinated; D006863:Hydrogen-Ion Concentration; D007773:Lactates / Q000097:blood*; D011422:Propionates / Q000494:pharmacology*; D011773:Pyruvates / Q000097:blood
D001786:Blood Glucose; D006843:Hydrocarbons, Chlorinated; D007773:Lactates; D011422:Propionates; D011773:Pyruvates; D005632:Fructose; C021974:2-chloropropionic acid; D004837:Epinephrine