title: Effect of dose of sodium saccharin on the induction of rat urinary bladder proliferation.
abstract: The effect of sodium saccharin fed to male F344 rats at levels of 5.0, 2.5, 1.0, 0.5, and 0.1% of the diet for 10 weeks was evaluated by autoradiography and scanning electron microscopy. A dose response was evident with both techniques. The labeling index was statistically significantly elevated at all doses above 0.1%. As observed by scanning electron microscopy, the number of foci containing ropy microridges or uniform microvilli was elevated at doses of 1.0, 2.5, and 5.0% of the diet, and pleomorphic microvilli were observed at the two highest doses.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D006965:Hyperplasia; D008297:Male; D008855:Microscopy, Electron, Scanning; D051381:Rats; D012439:Saccharin / Q000633:toxicity*; D001745:Urinary Bladder Diseases / Q000139:chemically induced* / Q000473:pathology
chemical_list: D012439:Saccharin