title: Synthesis and adrenergic blocking effects of 2-(alkylamino)-3,4-dihydroquinazolines.
abstract: Based on the known biological activity of a variety of guanidine-containing agents, several N-substituted 3,4-dihydroquinazolines were synthesized. These compounds can be considered to be rigid analogues of phenylguanidines. In anesthetized rats the compounds decreased blood pressure and were antagonists of the pressor response to norepinephrine.
mesh_terms: D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013565:Sympatholytics / Q000138:chemical synthesis*
chemical_list: D011799:Quinazolines; D013565:Sympatholytics; D009638:Norepinephrine