Pharmacokinetics of a new hypoglycemic agent SPC-703.
Pharmacokinetic of a new hypoglycemic agent, SPC-703 was studied in rats after iv, ip and po administration of two doses of the drug. It was found that biological half-time (t 1/2) did not depend upon the route of administration, t 1/2 value was 12.5-13.8 hr. There was no statistically significant difference in the pharmacokinetic parameters of SPC-703 after administration of two doses, 25 and 50 mg/kg of the drug. The volume of distribution of the unbound to serum protein SPC-703 was 93 ml, the volume of distribution assayed for the total amount of SPC-703 was 42.4 ml. SPC-703 in humans was absorbed rapidly from the gastrointestinal tract to the general circulation, ka = 1.21 hr-1, half-time of absorption was 0.65 hg (39 min). The volume of distribution of absorbed SPC-703 Vd/F was 10.1 l.
D000818:Animals; D003920:Diabetes Mellitus / Q000378:metabolism; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000378:metabolism*; D007408:Intestinal Absorption; D007700:Kinetics; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011720:Pyrazoles / Q000008:administration & dosage / Q000378:metabolism; D051381:Rats; D013453:Sulfonylurea Compounds / Q000008:administration & dosage / Q000378:metabolism*
D007004:Hypoglycemic Agents; D011720:Pyrazoles; D013453:Sulfonylurea Compounds; C009971:glipalamide