title: Suppression of anti-hapten IgE and IgG antibody responses by isologous anti-idiotypic antibodies against purified anti-carrier (ovalbumin) antibodies in BALB/c mice.
abstract: The studies described here show that BALB/c mice actively producing isologous anti-idiotypic antibodies (ald) after immunization with purified, syngeneic anti-OvA antibodies exhibit depressed anti-hapten and anti-carrier IgE and IgG antibody responses, provided that hapten-OVA conjugates are used to mount the immune responses. We suggest that carrier-specific helper T cells (CTh) for IgE and IgG antibody production carry idiotypes similar or identical to those among purified anti-OVA IgG antibodies. The mode of regulation of immune responses by anti-carrier-ald may be different from that exerted by anti-hapten-alD. Although anti-carrier-ald may block or deplete CTh and thereby prevent help for immunoglobulin production by B cells, anti-hapten-ald may induce T suppressor cells (Ts).
mesh_terms: D000818:Animals; D000906:Antibodies / Q000276:immunology*; D001200:Ascaris / Q000276:immunology; D002352:Carrier Proteins / Q000276:immunology; D004136:Dinitrobenzenes / Q000276:immunology; D005260:Female; D006241:Haptens / Q000276:immunology*; D007106:Immune Sera / Q000494:pharmacology; D007108:Immune Tolerance; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010047:Ovalbumin / Q000276:immunology; D010400:Penicillin G / Q000276:immunology
chemical_list: D000906:Antibodies; D002352:Carrier Proteins; D004136:Dinitrobenzenes; D006241:Haptens; D007106:Immune Sera; D007074:Immunoglobulin G; D007130:Immunoglobulin Idiotypes; D007073:Immunoglobulin E; D010047:Ovalbumin; D010400:Penicillin G