[Effect of prostaglandin F2 on the bladder muscles in women].
The effect of intravenous Pg F2 alpha on the detrusor muscle in young healthy females during filling cystometry and during a long period of pressure normalization was studied. It was possible to induce uninhibited detrusor contractions in two thirds of the cases, very much resembling those of patients with motor-urge-incontinence. The sensitivity of the uterus was found to be higher than that of the bladder. Both organs responded with a gradual tone increase followed by regular contractions of the uterus and more erratic contractions of the detrusor. Therapeutic studies with a Pg-synthesis inhibitor (Indometacin) were undertaken with moderate success.
D005260:Female; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use; D008365:Manometry; D009119:Muscle Contraction / Q000187:drug effects; D009129:Muscle Tonus / Q000187:drug effects; D011460:Prostaglandins F / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects*; D001750:Urinary Bladder, Neurogenic / Q000188:drug therapy
D011460:Prostaglandins F; D007213:Indomethacin
Die Wirkung von Prostaglandin F2 alpha auf die Harnblasen-Muskulatur der Frau.