Regional distribution of glutathione peroxidase in the adult rat brain.
Glutathione peroxidase activity was measured in 10 areas of perfused adult rat brain with the use of a fluorometric assay coupled to NADPH oxidation. The caudate-putamen and the substantia nigra had the highest activities. Cortical areas and several nuclear areas had somewhat lower activity. Activity was lowest in a white matter structure (corpus callosum). High activity of glutathione peroxidase may be related to the need to reduce hydrogen peroxide arising in the course of monoamine metabolism.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D005979:Glutathione Peroxidase / Q000378:metabolism*; D008297:Male; D010544:Peroxidases / Q000378:metabolism*; D051381:Rats; D013050:Spectrometry, Fluorescence; D014018:Tissue Distribution
D010544:Peroxidases; D005979:Glutathione Peroxidase