Ethanol-induced increase in brain concentrations of administered neutral amino acids.
Ethanol 2 g kg-1 i.p. to rat increased the concentrations in the brain of administered large neutral amino acids (tyrosine, tryptophan, 5-hydroxytryptophan and alpha-methyldopa). We have previously found a similar effect of ethanol on administered L-Dopa, resulting in increased brain/plasma ratios of dopa. Since large neutral amino acids are known to complete with each other for the carrier-mediated transport into the brain we suggest that the increased concentrations of the administered amino acids in the brain are at least partly the consequence of the ethanol-induced decrease in plasma amino acids observed previously.
D000596:Amino Acids / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D000431:Ethanol / Q000494:pharmacology*; D008297:Male; D051381:Rats
D000596:Amino Acids; D000431:Ethanol