title: Differentiation of glomerular filter and tubular reabsorption apparatus during foetal development of the rat kidney.
abstract: Differentiation of the glomerulus and the proximal tubule was studied in the rat foetus, especially with regard to the development of the protein filtration-reabsorption apparatus. Filtration starts several days before full differentiation of the glomerulus, when the glomerular basement membrane consists of a thin lamina alongside the podocyte membrane. Endocytosis is functional fom this time but fusion between endocytic vesicles and lysosome-like bodies occurs 2 days later. Foetal urine electrophoresis shows the presence of many proteins, including high molecular weight one, this proteinuria seeming chiefly due to the immaturity of the glomerular barrier.
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D004705:Endocytosis; D005333:Fetus / Q000648:ultrastructure; D005865:Gestational Age; D007678:Kidney Glomerulus / Q000196:embryology* / Q000648:ultrastructure; D007687:Kidney Tubules, Proximal / Q000196:embryology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D011507:Proteinuria; D051381:Rats