Serum gastrin response to secretin after vagotomy.
It is unknown whether the gastrin response to secretin (secretin test) can distinguish hypergastrinemia due to vagotomy from hypergastrinemia due to Zollinger-Ellison syndrome (ZES). Therefore, we measured serum gastrin concentrations basally and in response to intravenous secretin in 13 vagotomized duodenal ulcer patients without preoperative evidence evidence of ZES and in 5 vagotomized patients with ZES. Following secretin, serum gastrin concentrations increased 40 pg/ml or less [mean (+/- SE) rise 23 +/- 3 pg/ml] in the vagotomized patients without ZES. On the other hand, in the patients with ZES serum gastrin increments after secretin ranged from 105 to 1224 pg/ml. Thus, a large (> 100 pg/ml) rise in serum gastrin concentrations following secretin in a vagotomized patient should suggest Zollinger-Ellison syndrome and not be attributed to vagotomy per se.
D003937:Diagnosis, Differential; D004381:Duodenal Ulcer / Q000097:blood / Q000150:complications / Q000601:surgery; D005755:Gastrins / Q000097:blood*; D006728:Hormones / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D012633:Secretin / Q000008:administration & dosage; D014628:Vagotomy; D015043:Zollinger-Ellison Syndrome / Q000097:blood / Q000150:complications / Q000175:diagnosis
D005755:Gastrins; D006728:Hormones; D012633:Secretin