[Mechanisms of regulating monoamine oxidase activity in different brain regions].
Both in vitro and in vivo rates of oxidative deamination of 3H-dopamine (DA), 14C-tyramine (T), 14C-noradrenaline (NA), 3H-serotonine (S) and benzylamine (BA) by monoamine oxidases of homogenates of rat brain cortex, brain stem and basal ganglia were shown to be different either after administration of l-dihydroxyphenylalanine (l-DOPA) and of N1-d,l-seryl-N2/(2,3,4-trihydroxybenzyl) hydrazine (Ro 4-4602) or after their simultaneous administration into the animals. L-DOPA and Ro 4-4602, administered intraperitoneally at a dose of 50 mg/kg, did not affect distinctly the NA and S deamination in various parts of brain. Ro 4-4602 inhibited selectively the BA deamination in basal ganglia; simultaneous administration of the drug together with l-DOPA caused more pronounced inhibition of BA deamination; it decreased also the rate of deamination of DA and T in the ganglia. L-DOPA, Ro 4-4602 and their combination were especially effective at concentration 10(-4) M. These data characterize one of possible mechanisms of distinct antiparkinsonic action of these drugs. Ro 4-4602 was shown to inhibit the deamination of DA and S noncompetitively. L-DOPA (10(-5)--10(-4) M) activated selectively the DA deamination in brain mitochondria.
D000818:Animals; D001479:Basal Ganglia / Q000201:enzymology; D001545:Benserazide / Q000494:pharmacology*; D001596:Benzylamines / Q000378:metabolism; D001921:Brain / Q000201:enzymology*; D001933:Brain Stem / Q000201:enzymology; D002540:Cerebral Cortex / Q000201:enzymology; D004298:Dopamine / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006834:Hydrazines / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology*; D008297:Male; D008995:Monoamine Oxidase / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D012701:Serotonin / Q000378:metabolism; D014439:Tyramine / Q000378:metabolism
D001596:Benzylamines; D006834:Hydrazines; D012701:Serotonin; D007980:Levodopa; D001545:Benserazide; D008995:Monoamine Oxidase; D004298:Dopamine; D009638:Norepinephrine; D014439:Tyramine
O nekotorykh mekhanizmakh reguliatsii aktivnosti monoaminoksidaz v razlichnykh otdelakh mozga.