[Hypermineralcorticism syndrome secondary to topical application of 9-alpha-fluoroprednisolone (author's transl)].
A patient is reported who presented with severe arterial hypertension and pronounced hypokalemic metabolic alkalosis along with suppression of 17-hydroxicorticoids, plasma renin activity and urinary aldosterone excretion, in relation to topical application of 9-alpha-fluoroprednisolone, 300 mg weekly. The clinical picture changed after discontinuation of the steroid preparation. Whenever topical steroids are prescribed for extensive chronic skin the development of systemic side-effects must be watched. Depending on the type of steroid employed, Cushing's syndrome or a hypermineralcorticism state may appear. The differential diagnosis of a hypermineralcorticism syndrome without aldosteronism should include the possible topical application of fluorated steroids.
D000287:Administration, Topical; D000471:Alkalosis / Q000139:chemically induced*; D002648:Child; D005477:Fluprednisolone / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007008:Hypokalemia / Q000139:chemically induced*; D007057:Ichthyosis / Q000188:drug therapy
D005477:Fluprednisolone
Síndrome de hipermineralcorticismo por aplicaciíon tópica de 9-alfa-fluorprednisolona.