[Effect of prostaglandin F2 alpha on the acute toxicity of cholinergic drugs in mice].
Studies on white mice of acute toxicity of cholinergic drugs (carbachol, physostigmine, pilocarpine) intraperitoneally made it possible to ascertain the magnitudes of DL50 as follows: 2.5 mg/kg for carbachol, 0.644 mg/kg for physostigmine and 150 mg/kg for pilocarpine. Intraperitoneal administration of prostaglandins F2 alpha (10 and 25 mg/kg) 15 min before carbachol, physostigmine  and pilocarpine increased the toxicity of the drugs and considerably lowered their DL50, while the administration of the same doses of prostaglandins F2 alpha in control mice did not enhance side effects. The animals' survival after 24 hours elapsed was equal to 100%.
D000818:Animals; D002217:Carbachol / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010277:Parasympathomimetics / Q000633:toxicity*; D010830:Physostigmine / Q000633:toxicity; D010862:Pilocarpine / Q000633:toxicity; D011460:Prostaglandins F / Q000494:pharmacology
D010277:Parasympathomimetics; D011460:Prostaglandins F; D010862:Pilocarpine; D002217:Carbachol; D010830:Physostigmine
Vliianie prostaglandina F2 al'fa na ostruiu toksichnost' kholinergicheskikh lekarstvennykh veshchestv u mysheĭ.