[Influence of dicinone and taurine on the effects of prostaglandins].
In rabbit experiments, the local administration of prostaglandins E2 and F2 alpha provoked an increase in intraocular pressure because of hyperproduction of intraocular liquid and increased permeability of the histoophthalmic barrier. Local administration of dicinon and taurin elicited a protective action and prevented the hypertensive effect of prostaglandins. Dicinon and taurin did not produce any influence on spasmogenic and hemodynamic effects of prostaglandins on isolated preparations of smooth muscle organs. Therefore, the protective effect of the drugs in the prostaglandin-induced hypertension of the eye is not related to the antiprostaglandin properties shown by these drugs.
D000818:Animals; D001557:Benzenesulfonates / Q000494:pharmacology*; D002415:Cats; D004347:Drug Interactions; D004979:Ethamsylate / Q000494:pharmacology*; D005260:Female; D006168:Guinea Pigs; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007429:Intraocular Pressure / Q000187:drug effects; D008297:Male; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D011817:Rabbits; D051381:Rats; D013654:Taurine / Q000494:pharmacology*; D014599:Uterus / Q000187:drug effects
D001557:Benzenesulfonates; D011448:Prostaglandin Antagonists; D011458:Prostaglandins E; D011460:Prostaglandins F; D013654:Taurine; D004979:Ethamsylate
Vliianie ditsinona i taurina na nekotorye éffekty prostaglandinov.