[Study on a mock cerebro-spinal fluid (author's transl)].
The work presented was initiated in order to evaluate the biological and clinical tolerance of the isotonic saline solution (9 p. mille) usually used in neuro-surgery directly in contact with the nervous tissue in comparison with a new solution proposed as a a mock cerebrospinal fluid. Clinically, two patient' populations including 75 patients each, were compared during dynamic investigation of intracranial pressure with intra-ventricular injections of different solutions. The effects of prolonged intra-ventricular perfusion with each solution were studied in animal models by: --electrophysiological analysis of EEG activity during perfusion --morphological observation: electronic microscopy of different cerebral structures after the perfusion. The biological tolerance was analyzed by the use of routine tissue culture of CNS tissue exposed to the two solutions. The results obtained show the toxicity of isotonic saline solution (9 p. mille) and the perfect tolerance of S.21.001 solution as a mock cerebro-spinal fluid.
D000818:Animals; D002478:Cells, Cultured; D002555:Cerebrospinal Fluid; D002831:Choroid Plexus / Q000098:blood supply / Q000648:ultrastructure; D004569:Electroencephalography; D006801:Humans; D007276:Injections, Intraventricular; D007427:Intracranial Pressure; D007552:Isotonic Solutions; D008854:Microscopy, Electron; D010477:Perfusion; D011817:Rabbits; D012965:Sodium Chloride / Q000494:pharmacology*
D007552:Isotonic Solutions; D012965:Sodium Chloride
Etude d'un liquide céphalo-rachidien artificiel.