BBM-928, a new antitumor antibiotic complex. I. Production, isolation, characterization and antitumor activity.
A complex of the antitumor antibiotic BBM-928 was produced by an actinomycete strain No. G455-101. Four components, BBM-928 A, B, C and D, were isolated in crystalline form and characterized. They were shown to be cyclic depsipeptide antibiotics containing a quinoline nucleus as the chromophore. BBM-928 A is a monoacetyl derivative of BBM-928 B and a diacetyl derivative of BBM-928 C. BBM-928 components exhibit antimicrobial activity against Gram-positive and acid-fast bacteria. BBM-928 A is highly active in mice against various experimental tumors including leukemia P388, leukemia L1210, melanoma B16, LEWIS lung carcinoma and sarcoma 180. BBM-928 B is less active than BBM-928 A, and BBM-928 C has no antitumor activity.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D005285:Fermentation; D007928:Lethal Dose 50; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D011804:Quinolines / Q000096:biosynthesis / Q000302:isolation & purification / Q000494:pharmacology
D000903:Antibiotics, Antineoplastic; D011804:Quinolines; C029834:BBM-928 D; C027844:BBM-928