title: Comparison of conduits for leg revascularization.
abstract: The saphenous vein (SV) remains the conduit of choice for lower limb revascularization. When SV is unavailable, or unsuitable, two alternative conduits have been employed: gluteraldehydestablized human umbilical vein (HUV) and polytetrafluoroethylene (PTFE). In this study of the 218 patients who underwent lower limb revascularization, 3-year patency of 85 SV graft was 75% compared to 34% for the 66 HUV grafts and 33% for the 67 PFTE grafts. Three factors were found to independently influence patency: the indication for surgery, the site of the distal anastomosis, and the angiographic runoff. The SV group had significantly better patency than either HUV or PFTE in each of these subgroups. No consistent difference between HUV and PTFE was found. A risk score was obtained by assigning a value of 1 to 3 for each of the factors influencing patency--indication: 1 = claudication, 2 = rest pain, 3 = ischemic lesions; site: 1 = above knee (AK), 2 = below knee (BK), 3 = tibial; runoff 1 = good (two or three vessels), 2 = fair (one vessel), 3 = poor (no vessel). Patients with the lowest risk scores (3 to 4) had the best 3-year patency: SV, 78%; HUV, 44%; and PTFE, 48%. Patients with the highest risk scores (7 to 9) had the worst 3-year patency: SV, 68%; HUV, 32%; and  PTFE, 28%. SVs had better patency under high- and low-risk conditions and remain the conduit of choice for lower limb revascularization. Both HUV and PTFE have equivalent and acceptable patency when SV is unavailable or unstable.
mesh_terms: D001807:Blood Vessel Prosthesis; D005263:Femoral Artery / Q000601:surgery; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000098:blood supply*; D011138:Polytetrafluoroethylene; D011150:Popliteal Artery / Q000601:surgery; D012501:Saphenous Vein / Q000637:transplantation*; D013927:Thrombosis / Q000601:surgery; D014182:Transplantation, Autologous / Q000379:methods; D014471:Umbilical Veins / Q000637:transplantation*
chemical_list: D011138:Polytetrafluoroethylene