Effects of contrast media on circulating blood volume. A comparative investigation of various sites of injection.
Changes in the circulating blood volume following injection of different contrast media and at different sites have been measured in the dog. The results confirm that osmoreceptors in the right atrium play a role for changes in blood volume following injection of a contrast medium. The differential response to individual agents was mainly a function of their osmolality. Atropine appears to moderate the changes.
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001810:Blood Volume / Q000187:drug effects*; D003287:Contrast Media / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D005950:Glucose Solution, Hypertonic / Q000494:pharmacology; D007267:Injections; D007483:Iothalamic Acid / Q000494:pharmacology; D008793:Metrizamide / Q000494:pharmacology; D014882:Water-Electrolyte Balance / Q000187:drug effects
D003287:Contrast Media; D005950:Glucose Solution, Hypertonic; D007483:Iothalamic Acid; D001285:Atropine; D008793:Metrizamide