[Effect of nonachlazine on systemic hemodynamics and the collateral coronary circulation in acute myocardial ischemia].
Systemic hemodynamics (thermodilution), retrograde coronary blood flow, oxygen tension and bioelectric activity of the myocardium were examined in dog experiments to show that nonachlazin produces an intensive and long-lasting increase in the collateral blood flow to the zone of acute myocardial ischemia and in the pressure in the ligated venous artery. Concurrently it elevates oxygen tension in the affected part of the heart. The cardiostimulant effect of the drug was associated with augmentation of the heart volume on account of an elevated stroke output in the presence of diminished general peripheral vascular resistance.
D000208:Acute Disease; D000818:Animals; D002316:Cardiotonic Agents; D003097:Collateral Circulation / Q000187:drug effects*; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D009628:Nonachlazine / Q000627:therapeutic use*; D010640:Phenothiazines / Q000627:therapeutic use*
D002316:Cardiotonic Agents; D010640:Phenothiazines; D009628:Nonachlazine
Vliianie nonakhlazina na sistemnuiu gemodinamiku i kollateral'noe koronarnoe krovoobrashchenie pri ostroĭ ishemii miokarda.