title: The present status of meprobamate ingestion. A five-year review of cases with serum concentrations and clinical findings.
abstract: Fifty-seven cases of meprobamate ingestion from 1974 through 1979 were reviewed. Serum meprobamate concentrations, clinical findings, and epidemiologic data were studied to determine the present status of the abuse of this compound. The average patient was a 37-year-old woman who ingested meprobamate and at least one other drug (usually a benzodiazepine, a barbiturate, ethanol, or an opiate) in a suicide attempt of gesture. She arrived at the hospital either alert or lethargic with equal frequency. Half of the time she was seen only in the emergency room, and half of the time she was hospitalized. She was usually treated with supportive care alone and survived the ingestion. Serum meprobamate concentrations exceeding 12 mg/dl were consistent with coma. Dysarthria, hypotension, tachycardia, and ataxia were the most common physical findings. Meprobamate addiction was present in six patients.
mesh_terms: D000293:Adolescent; D000328:Adult; D003243:Consciousness / Q000187:drug effects; D005260:Female; D006207:Half-Life; D006801:Humans; D008297:Male; D008620:Meprobamate / Q000097:blood*; D008875:Middle Aged; D019966:Substance-Related Disorders / Q000097:blood* / Q000628:therapy; D013997:Time Factors
chemical_list: D008620:Meprobamate