Effects of injectable famphur on young Brahman and Angus cattle.
Clinical responses were monitored in young Angus and Brahman bulls given IM injections of an experimental solution of 35% famphur in a dose 5 times greater than the recommended dose (83.2 mg/kg). Five of the 6 treated Brahman bulls had severe clinical signs of organophosphorous toxicosis, and 4 died within 48 hours after they were dosed. Only 1 of the 5 treated Angus bulls showed clinical signs of toxicosis and it recovered. In a subsequent trial, clinical and cholinesterase responses were monitored in young Brahman bulls, steers, and heifers given famphur at different dosages. Highly significant (P < 0.001) RBC cholinesterase inhibition over the 28-day trial was observed in animals given 16.6, 33.3, and 49.9 mga of the drug/kg. In comparison to Brahman heifers and steers, a lower treatment level of famphur (33.3 mg/kg) induced toxicosis in bulls. However, no significant differences in RBC or plasma cholinesterase inhibition were found to be due to treatment-sex interactions.
D000818:Animals; D001947:Breeding; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000139:chemically induced*; D002802:Cholinesterases / Q000097:blood; D005260:Female; D007273:Injections, Intramuscular; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000633:toxicity*; D012737:Sex Factors; D013449:Sulfonamides / Q000008:administration & dosage / Q000633:toxicity
D007306:Insecticides; D063086:Organothiophosphates; D009946:Organothiophosphorus Compounds; D013449:Sulfonamides; C004992:famophos; D002802:Cholinesterases