Dose-dependent effect of trichloropropene oxide on benzo[a]pyrene carcinogenesis.
The epoxide hydratase inhibitor, 1,1,1-trichloro-2,3-propene oxide (TCPO) in combination with benzo[a]pyrene (B[a]P) was injected s.c. in ddN mice. The formation of fibrosarcoma by B[a]P was slightly accelerated at low dose of TCPO, and remarkably inhibited at high dose of TCPO. The correlation of carcinogenesis with B[a]P metabolism was discussed.
D000818:Animals; D001580:Benzopyrenes; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D005354:Fibrosarcoma / Q000139:chemically induced*; D006843:Hydrocarbons, Chlorinated / Q000009:adverse effects*; D007279:Injections, Subcutaneous; D051379:Mice; D012513:Sarcoma, Experimental / Q000139:chemically induced; D014239:Trichloroepoxypropane / Q000008:administration & dosage / Q000009:adverse effects*
D001580:Benzopyrenes; D006843:Hydrocarbons, Chlorinated; D014239:Trichloroepoxypropane