Examination of newly synthesized 2-chloroethyl-nitrosoureas on rat leukemia L 5222.
The preterminal intraperitoneal implanted rat leukemia L 5222 was used to test the chemotherapeutic activity of 10 newly synthesized nitrosoureas: ethylmethanesulfonato-CNU, acetamido-CNU, dihydroxypropyl-CNU, carboxyethyl-CNU, cyanoethyl-CNU, morpholino-CNU, piperidino-CNU, methylene-dioxybenzyl-CNU, methylene-3-pyridyl-CNU and methylene-4-pyridyl-CNU; their activity was compared against BCNU, CCNU, MeCCNU and hydroxyethyl-CNU. All compounds tested showed a more or less pronounced chemotherapeutic activity. MeCCNU was superior to all other compounds investigated. The predictive value for human tumors of results obtained from a model which is highly sensitive to nitrosoureas is discussed.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005038:Ethylnitrosourea / Q000031:analogs & derivatives / Q000627:therapeutic use*; D005260:Female; D007942:Leukemia, Experimental / Q000188:drug therapy*; D008297:Male; D009607:Nitrosourea Compounds / Q000627:therapeutic use*; D051381:Rats; D011919:Rats, Inbred Strains; D013329:Structure-Activity Relationship
D009607:Nitrosourea Compounds; C017139:1-(2-chloroethyl)-1-nitrosourea; D005038:Ethylnitrosourea