In-vitro toxicity of acetone using coronary perfusion in isolated rabbit heart.
In-vitro toxicity of acetone using isolated rabbit heart is reported. The hearts were perfused using Langendorf's procedure and modified Anderson's coronary perfusion apparatus. Heart rate and force of contraction were recorded mechanically and the coronary flow was measured manually. The force of contraction was significantly reduced; heart rate and coronary flow were significantly increased with acetone concentrations of 0.5% and 1.0% V/V.
D000096:Acetone / Q000633:toxicity*; D000818:Animals; D003326:Coronary Circulation / Q000187:drug effects; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D010477:Perfusion; D011817:Rabbits; D013997:Time Factors
D000096:Acetone