Experimental elastosis induced by chronic ultraviolet exposure. Light- and electron-microscopic study.
The effect of long-term ultraviolet irradiation on the connective tissue of the skin was investigated in 25 naked (Ng/-) mice which received a total daily radiant dose of 40 +/- 2 J/cm2 for a period of 8.5 months. The produced alterations were very similar to those found in actinic elastosis of humans, as assessed by histologic and electron-microscopic criteria.
D000818:Animals; D003094:Collagen / Q000378:metabolism; D003238:Connective Tissue / Q000528:radiation effects*; D004547:Elastic Tissue / Q000528:radiation effects*; D005260:Female; D051379:Mice; D008854:Microscopy, Electron; D014466:Ultraviolet Rays / Q000009:adverse effects*
D003094:Collagen