title: The relationship between maternal and infant iron status.
abstract: Serum ferritin, iron and haemoglobin (Hb) concentrations were determined in 103 pregnant women and in the cord of their normal full-term offspring. In 50 of the cases the placental non-haem iron was also measured. The correlations between serum ferritin concentration and other measurements of iron status were similar in both maternal and cord blood suggesting that cord serum ferritin concentration may, as in adults, reflect neonatal iron stores. The inverse relationship found between cord serum ferritin and hb concentrations (r = -0.35, P less than 0.001) suggests that the amount of iron in foetal stores is influenced by that required for Hb. When Hb levels are elevated, as was demonstrated in babies of older mothers, significantly lower serum ferritin were found. Thus a low cord serum ferritin concentration does not necessarily indicate that less iron was transferred to the foetus. Maternal iron reserve, as reflected by serum ferritin concentration, was shown to be related to the amount of non-haem iron in the placenta (r = 0.41, P less than 0.005), but this iron does not seem to form part of foetal iron stores as it does not correlate with measurements of foetal iron status. A week correlation between cord and maternal serum ferritin concentrations was demonstrated (r = 0.21, P less than 0.05) but its biological significance is questionable.
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005293:Ferritins / Q000097:blood*; D005312:Fetal Blood / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007231:Infant, Newborn; D007501:Iron / Q000378:metabolism*; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000032:analysis; D011247:Pregnancy
chemical_list: D006454:Hemoglobins; D005293:Ferritins; D007501:Iron