Alteration of the baroreceptor reflex by an effect of propranolol on the isolated carotid sinus.
The present experiments were designed to measure and characterize direct hemodynamic effects of propranolol on vascularly isolated carotid sinuses. dl-Propranolol, when restricted to the isolated carotid sinuses, inhibited in a dose-dependent manner the reflex increases in heart rate and mean arterial pressure during carotid sinus hypotension. When perfused through isolated sinuses at a concentration of 10 micrograms/ml, the drug totally abolished reflex changes to carotid sinus hypotension. Perfusion of the sinuses with d-propranolol or procaine at the same doses also totally inhibited the response. On the other hand, perfusion of the sinuses with sotalol, an adrenergic blocker without membrane stabilizing effects, did not alter resting levels of arterial pressure or heart rate and did not affect reflex changes during sinus hypotension. These results suggest that propranolol at high doses may affect baroreceptor afferents and inhibit the baroreceptor reflex through membrane-stabilizing and local anesthetic properties rather than through hypothesized beta receptors. It seems unlikely that these pathways contribute to the antihypertensive actions of the drug.
D000818:Animals; D002346:Carotid Sinus / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D011311:Pressoreceptors / Q000187:drug effects*; D011343:Procaine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*; D013015:Sotalol / Q000494:pharmacology
D011343:Procaine; D011433:Propranolol; D013015:Sotalol