[Reducing of unwanted side effects of modified fluid gelatin by promethazine: controlled clinical trial with orthopaedic patints (author's transl)].
In order to determine the undesirable side effects of standard commercially available plasma substitutes, 450 stationary patients covering 5 age groups were randomly allocated to various methods of pre-medication and 3 batches of modified fluid gelatin (Neo-Plasmagel). The incidence of allergoid and anaphylactoid reactions depended on the pre-medication (p less than 0.025). Atosil proved to be an strong histamine blocker: the incidence of reactions between the control and the promethazine group was p less than 0.005. Seen as a whole reactions among females were greater than with males (p less than 0.025). No relationship could be determined statistically between the different batches and the incidence of side-effects. -The prophylactic use of Neo-Plasmagel in orthopaedic patients is therefore dependent on a sufficient blockade of histamine receptors.
D000328:Adult; D005260:Female; D005780:Gelatin / Q000009:adverse effects*; D006801:Humans; D006967:Hypersensitivity / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D010952:Plasma Substitutes / Q000009:adverse effects*; D011292:Premedication; D011398:Promethazine / Q000627:therapeutic use*
D010952:Plasma Substitutes; D005780:Gelatin; D011398:Promethazine
Suppression der Nebenwirkungsquote von Neo-Plasmagel durch Promethazin.