[Aspects of the mechanism of the intracranial hypotensive effect of althesin in man].
40-50 microliters/kg of Althesin were rapidly injected i.v. into 8 conscious neurosurgical patients on spontaneous ventilation (30-40 minutes after 0,5 mg atropine sulphate i.m.) for a total of 11 administrations. Electroencephalogram (EEG), intracranial pressure (PIC), systemic arterial blood pressure (PA) and central venous pressure (PVC) were continuously and simultaneously recorded. In four patients paCO2 was monitored. Slowing of EEG (accepted as an index of the brain metabolic depression) and lowering of the PIC occurred at the same time (P less than or equal to 0,001) and preceded the decrease in PA (P < 0,05) and in PVC (P < 0,05). These pressure changes were associated with both increases and decreases in paCO2. The data agrees with the hypothesis that the intracranial hypotensive effect of Althesin can be due to the induced metabolic brain depression through the secondary autoregulation of the cerebral blood flow (FEC).
D000530:Alfaxalone Alfadolone Mixture / Q000008:administration & dosage / Q000494:pharmacology*; D000771:Anesthesia, Intravenous; D001794:Blood Pressure / Q000187:drug effects; D004341:Drug Evaluation; D004569:Electroencephalography; D006801:Humans; D007427:Intracranial Pressure / Q000187:drug effects*; D009493:Neurosurgery
D000530:Alfaxalone Alfadolone Mixture
Studio nell'uomo di alcuni aspetti del meccanismo dell'effetto ipotensivo intracranico dell'althesin.