Effect of combined surgical and chemotherapeutic treatment of Lewis lung carcinoma.
The effect of combined surgical and chemotherapeutic treatment on Lewis lung carcinoma was studied. The i.m. implanted primary tumor was removed on the 10th day after transplantation, and the survival of mice was registered. Cyclophosphamide proved to be the most effective among the drugs studied (Cyclophosphamide, 5-FU, DBD, CCNU, Adriamycin, Vincristin, Hexyldeoxyuridine). Using different schedules (pre- and/or post-operative treatment) the pre- and post-operative drug administration was the most advantageous. Combined therapy showed always better effect than monotherapy.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002277:Carcinoma / Q000188:drug therapy / Q000601:surgery; D004359:Drug Therapy, Combination; D008175:Lung Neoplasms / Q000188:drug therapy / Q000601:surgery; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009362:Neoplasm Metastasis; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000601:surgery
D000970:Antineoplastic Agents