Lecithin supplementation in healthy volunteers: effect on cholesterol esterification and plasma, and bile lipids.
Plasma and bile lipids and in vitro cholesterol esterifying activity of plasma (mg CE/dl/6 h) were determined in healthy volunteers who supplemented their regular diets with 7.5 g doses of soya lecithin three times daily for a 4-week period. Lecithin ingestion by the 4 male and 6 female subjects did not produce any significant changes either in total plasma cholesterol (TC) level or cholesterol esterification. A small but significant reduction was observed in the plasma triglyceride (TG) and total phospholipid (TPL) levels after supplementation. The molar percent of bile acids (BA), TC and TPL as well as the lithogenic index (LI = TC/BA + TPL) in both hepatic and gallbladder bile were also unaltered by 4 weeks of lecithin supplementation. In vitro cholesterol esterification was found linearly related to plasma-free cholesterol (r = 0.60, p less than 0.01) cholesterol ester (r = 0.50, p less than 0.05), total phospholipid (r = 0.50, p less than 0.05), lecithin (r = 0.45, p less than 0.05), and triglyceride (r = 0.57, p less than 0.025) levels.
D000328:Adult; D000924:Anticholesteremic Agents / Q000494:pharmacology*; D001646:Bile / Q000378:metabolism; D002784:Cholesterol / Q000378:metabolism; D002788:Cholesterol Esters / Q000378:metabolism; D004032:Diet; D005260:Female; D006801:Humans; D050356:Lipid Metabolism; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism; D010713:Phosphatidylcholines / Q000494:pharmacology*; D010743:Phospholipids / Q000378:metabolism; D014280:Triglycerides / Q000378:metabolism
D000924:Anticholesteremic Agents; D002788:Cholesterol Esters; D010713:Phosphatidylcholines; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase