Acquired isolated factor X deficiency associated with systemic amyloidosis. Case report and review of literature.
The demonstration of acquired isolated factor X deficiency and of a biclonal homogeneous lambda and kappa light polypeptide chain proteinuria in a patient of 49 years having an obscure hepatomegaly gave clinical evidence for the rate, amyloidosis-associated factor X deficiency, which could be proven by postmortem examination. The mechanisms by which amyloid may affect factor X levels in this case may be preferentially binding to the amyloid fibrils of lambda light chain type.
D000686:Amyloidosis / Q000150:complications*; D001536:Bence Jones Protein / Q000032:analysis; D005171:Factor X Deficiency / Q000209:etiology*; D005260:Female; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D007020:Hypoprothrombinemias / Q000209:etiology*; D008875:Middle Aged; D011507:Proteinuria / Q000378:metabolism*; D012187:Retroperitoneal Space
D001536:Bence Jones Protein