Polyalveolar lobe: anatomic and physiologic parameters and their relationship to congenital lobar emphysema.
Polyalveolar lobe is one of the recently described pathological entities that can give rise to congenital lobar emphysema (CLE). In polyalveolar lobe, the total alveolar number as determined by microscopic point-counting of randomly taken lung sections is increased three to fivefold. The airways and arteries are normal for age in number, size and structure. Follow-up over 10-20 yr of patients operated upon for congenital lobar emphysema, including those of polyalveolar lobe etiology shows that these patients do well clinically. All patients have some pulmonary function abnormalities, specifically a decrease in airway conductance, and forced expiratory volume. It is not possible to distinguish patients with polyalveolar lobes from other CLE patients on the basis of pulmonary function data. All patients had normal lung volumes and vital capacities, despite losing 8%-20% of their pulmonary parenchyma. Based on compensatory lung growth, it may be preferable to operate earlier, rather than later in these cases.
D002675:Child, Preschool; D000013:Congenital Abnormalities / Q000175:diagnosis; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D011013:Pneumonectomy; D011650:Pulmonary Alveoli / Q000002:abnormalities* / Q000473:pathology; D011656:Pulmonary Emphysema / Q000151:congenital* / Q000209:etiology / Q000473:pathology; D012129:Respiratory Function Tests; D012189:Retrospective Studies