title: The metabolic fate of a herbicidal methylmercapto-s-triazine (cyanatryn) in the rat.
abstract: 1. A major route of metabolism of the methylmercaptotriazine herbicide cyanatryn involves S-oxygenation. 2. The S-oxide reacts spontaneously with glutathione affording a conjugate, which is eliminated in the bile, and a mercapturic acid which is eliminated in the urine. 3. A small proportion of the administered dose was covalently bound to a component of the blood, probably haemoglobin. This was shown to be dependent on the formation of the S-oxide and on the species of animal studied. 4. No reactivity of the S-oxide towards DNA in vivo or in vitro could be demonstrated.
mesh_terms: D000111:Acetylcysteine / Q000652:urine; D000818:Animals; D005243:Feces / Q000032:analysis; D005260:Female; D005978:Glutathione / Q000378:metabolism; D006540:Herbicides / Q000032:analysis / Q000378:metabolism*; D008099:Liver / Q000032:analysis; D008297:Male; D051381:Rats; D014227:Triazines / Q000032:analysis / Q000378:metabolism*
chemical_list: D006540:Herbicides; D014227:Triazines; D005978:Glutathione; C010435:cyanatryn; D000111:Acetylcysteine