[Chronic copper toxicity of the liver in rat: preliminary observations].
Chronic copper administration to rats (0,125% Cu acetate in drinking water for 1 month) produced no liver necrosis as assessed by SGOT release and liver histology. However when the liver was isolated from Cu++ treated animals and in vitro perfused, bile flow and BSP excretion were significantly reduced respect to controls. Our data suggest that accumulation of copper in the hepatocytes may cause a functional liver impairment before overt structural damage become evident.
D000818:Animals; D001646:Bile / Q000187:drug effects; D001647:Bile Acids and Salts / Q000378:metabolism; D056486:Chemical and Drug Induced Liver Injury / Q000503:physiopathology*; D003300:Copper / Q000633:toxicity*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats
D001647:Bile Acids and Salts; D003300:Copper
Tossicita epatica del rame in corso di intossicazione cronica nel ratto: osservazioni preliminari.