[Experimental study of the neurotropic activity of lithium oxybutyrate].
Comparative experimental study of the known antimanic drug lithium carbonate and the original compound lithium oxybutyrate that possesses a neurotropic activity similar to that of lithium carbonate has shown lithium oxybutyrate to elicit a more prolonged and more pronounced central depressant action, and a significantly less toxicity. Lithium oxybutyrate is well soluble that makes it possible to use it as injections required for rapid arrest of manic conditions.
D000818:Animals; D002254:Carbonates / Q000494:pharmacology; D002490:Central Nervous System / Q000187:drug effects*; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004569:Electroencephalography; D006885:Hydroxybutyrates / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009942:Organometallic Compounds; D011817:Rabbits; D051381:Rats; D012890:Sleep / Q000187:drug effects; D013997:Time Factors
D002254:Carbonates; D006885:Hydroxybutyrates; D009942:Organometallic Compounds; C022826:lithium hydroxybutyrate; D008094:Lithium
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