title: Aging, Diseases and X-chromatin.
abstract: X-chromatin of the buccal epithelium was determined in women aged 3-107 years. The frequency of sex chromatin occurence increase with maturation and decreases again after the menopause. The distribution of women of the child-bearing age according to X-chromatin occurence has bimodal form. With aging both modes merge. The magnitude of this change is connected with the state of health. Delayed confluence of modal variants is observed in patients with dyshormonal tumours of genital organs and the mammary gland, as well as in patients with arterial hypertension. The hypothesis that the female population consists of two subpopulations, differing by constitutional peculiarities of the endocrine regulation, is discussed.
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging; D002318:Cardiovascular Diseases / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008593:Menopause; D008598:Menstruation; D008875:Middle Aged; D009369:Neoplasms / Q000235:genetics; D012728:Sex Chromatin / Q000032:analysis*