Tumor-induced osteomalacia. Evidence of a surgically correctable alteration in vitamin D metabolism.
A 15-year-old boy was treated for nonfamilial hypophosphatemic rickets. Treatment with ergocalciferol, 100,000 units/day, and phosphorus, 2 to 4 g/day, failed to alleviate the rickets. Levels of 1 alpha, 25-dihydroxyvitamin D were low while levels of 25-hydroxyvitamin D were elevated. After removal of a benign fibroma, the level of 1 alpha, 25-dihydroxyvitamin D increased, the serum phosphorus level became normal, and the osteomalacia was cured. The alteration of vitamin D metabolism and associated hypophosphatemia in oncogenic osteomalacia is a potentially reversible cause of bone disease mediated by the tumor.
D000293:Adolescent; D001859:Bone Neoplasms / Q000150:complications* / Q000378:metabolism / Q000601:surgery; D005350:Fibroma / Q000150:complications*; D006801:Humans; D008297:Male; D010018:Osteomalacia / Q000209:etiology* / Q000628:therapy; D010281:Parathyroid Hormone / Q000097:blood; D010710:Phosphates / Q000097:blood / Q000652:urine; D011182:Postoperative Care; D011300:Preoperative Care; D014807:Vitamin D / Q000378:metabolism*
D010281:Parathyroid Hormone; D010710:Phosphates; D014807:Vitamin D