Effect of chronic administration of morphine on primary immune response in mice.
The effect of 3 different doses of chronically-administered morphine on the primary immune response was studied in mice by estimating spleen/body weight ratio and serum hemolysin production against sheep red blood cells (SRBC). It was observed that morphine exerted a dose-dependent inhibitory effect on the immune response which was antagonized by the concomitant administration of naloxone. The findings suggest that the inhibitory effect of morphine is specific.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006460:Hemolysin Proteins / Q000276:immunology; D007109:Immunity / Q000187:drug effects*; D007700:Kinetics; D051379:Mice; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D013154:Spleen / Q000276:immunology
D006460:Hemolysin Proteins; D009270:Naloxone; D009020:Morphine