[Effect of the structural characteristics of the alkyl derivatives of imidazole and pyrazole dicarboxylic acid diamides on body respiratory functions].
It has been ascertained that alkyl derivatives of imidazoledicarboxylic acid diamides produce different effect on respiration and acid-base balance (ABB) of animal body. Antiphein and ethymisole stimulate respiration and change ABB. Ethirazol does not affect respiration, producing only insignificant changes in the respiratory component of ABB. Differences in the biological activity of the test drugs may be related to the structure or position of the alkyl radical in the heterocyclic ring.
D000136:Acid-Base Equilibrium / Q000187:drug effects; D000478:Alkylation; D000818:Animals; D002415:Cats; D005042:Etimizol / Q000494:pharmacology*; D007093:Imidazoles / Q000494:pharmacology*; D008968:Molecular Conformation; D010313:Partial Pressure; D011720:Pyrazoles / Q000494:pharmacology*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects*; D013329:Structure-Activity Relationship
D007093:Imidazoles; D011720:Pyrazoles; C011816:etipirol; C014337:Antiphein; D005042:Etimizol
Vliianie osobennosteĭ struktury nekotorykh alkilproizvodnykh diamidov imidazol- i pirazoldikarbonovykh kislot na dykhatel'nye funktsii organizma.