[Inhibition by the high density lipoprotein HDL2 and HDL3 of DNA and sterol biosynthesis in human lymphocytes stimulated with concanavalin A].
Lipoproteins HDL2 and HDL3 inhibit DNA synthesis and sterol synthesis in human Con A-stimulated lymphocytes cultured in a medium supplemented with 20 per cent lipoprotein deficient serum. On the basis of the amount of proteins added, HDL2 is more efficient on DNA and sterol synthesis than HDL3 and less efficient than LDL. However, on the basis of the amount of cholesterol added, the inhibition of sterol synthesis induced by these three lipoproteins is not significantly different. At all concentrations of these three lipoproteins, the inhibition of sterol synthesis is higher than the inhibition of DNA synthesis.
D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology; D004247:DNA / Q000096:biosynthesis*; D006801:Humans; D008075:Lipoproteins, HDL / Q000502:physiology*; D053439:Lipoproteins, HDL2; D053440:Lipoproteins, HDL3; D008077:Lipoproteins, LDL / Q000502:physiology; D008214:Lymphocytes / Q000378:metabolism*; D013261:Sterols / Q000096:biosynthesis*
D008075:Lipoproteins, HDL; D053439:Lipoproteins, HDL2; D053440:Lipoproteins, HDL3; D008077:Lipoproteins, LDL; D013261:Sterols; D003208:Concanavalin A; D004247:DNA
Inhibition par les lipoprotéines de haute densité HDL2 et HDL3 de la synthèse du DNA et des stérols des lymphocytes humains stimulés par la concanavaline A.