Microbial conversion of anthracyclinones to daunomycin by blocked mutants of Streptomyces coeruleorubidus.
Baumycin-negative mutants of Streptomyces coeruleorubidus ME130-A4 do not convert daunomycinone to daunomycin and baumycins. They biosynthesize daunomycin from aklavinone and epsilon-rhodomycinone, indicating the glycosidation of the aglycone before the synthesis of daunomycinone. The biosynthetic pathway from epsilon-rhodomycinone to daunomycin was further confirmed by studying the bioconversion of anthracyclinones and anthracyclines, which are presumed to be intermediates.
D001711:Biotransformation; D003470:Culture Media; D003630:Daunorubicin / Q000096:biosynthesis*; D006027:Glycosides / Q000378:metabolism; D009154:Mutation; D009279:Naphthacenes / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism*
D003470:Culture Media; D006027:Glycosides; D009279:Naphthacenes; D003630:Daunorubicin