title: Evolution of diethylstilbestrol-associated genital tract lesions.
abstract: The evolution of the colposcopic manifestations of adenosis involving the cervicovaginal hood and vagina was determined by the long-term follow-up of 173 diethylstilbestrol-exposed women. Serial gross observations in conjunction with histopathologic data showed that adenosis is a dynamic lesion that undergoes progressive squamous metaplasia over time. Ultimately, adenosis may disappear completely, to be replaced by normally glycogenated mucosa. A schema for the evolution of adenosis is presented.
mesh_terms: D002584:Cervix Uteri / Q000473:pathology; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D005500:Follow-Up Studies; D005836:Genitalia, Female / Q000473:pathology*; D006801:Humans; D014621:Vagina / Q000473:pathology
chemical_list: D004054:Diethylstilbestrol