[PO2 and PCO2 after nifedipine administered by the sublingual route in hypertensive patients (author's transl)].
The Authors have examined the PO2 and PCO2 of peripheral arterial blood in 10 hypertensive subjects before and after 20 mg of nifedipine administered by sublingual route. A PaO2 decrease and a light increase of PaCO2 were observed; this pattern, if considered together with the increase of CO2 and the decrease of pulmonary resistance, may be attributed to a greater perfusion of those districts having a low V/Q ratio.
D000284:Administration, Oral; D000328:Adult; D001784:Blood Gas Analysis; D004341:Drug Evaluation; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage*; D010313:Partial Pressure; D011725:Pyridines / Q000008:administration & dosage*
D011725:Pyridines; D009543:Nifedipine
Comportamento dei parametri emogasometrici dopo somministrazione di nifedipina per via sublinguale in soggetti ipertesi.