[Effect of apomorphine and haloperidol on the immune reaction].
It has been established that injection of apomorphine leads to the dose-dependent enhancement of the immune response in CBA mice whereas that of haloperidol suppresses the number of rosette-forming cells. After thymectomy apomorphine does not stimulate rosette-formation. This indicates that the thymus participates in the realization of apomorphine action. Preliminary injection of haloperidol prevents the apomorphine-induced enhancement of the immune response. The results suggest that the enhancement is mediated through the activation of dopamine receptors.
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D001058:Apomorphine / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D006220:Haloperidol / Q000276:immunology*; D007114:Immunization; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D012397:Rosette Formation; D013934:Thymectomy; D013997:Time Factors
D006220:Haloperidol; D001058:Apomorphine
Vliianie apomorfina i galoperidola na immunnuiu reaktsiiu.