[Bioavailability of digoxin tablets in cardiac insufficiency patients].
The bioaccessibility of Soviet produced digoxin tablets in elderly patients with cardiac insufficiency was studied. It is shown that in absolute bioaccessibility (62%) and other biopharmaceutic indices digoxin tablets made in the Soviet Union are equivalent to lanoxin tablets of the Burroughs Wellcome firm which are accepted by the USA FDA as the bioaccessibility standard. Equations fitted within a two-part mathematical model satisfactorily describe the changes in blood serum digoxin concentration in oral medication and in intravenous administration.
D000368:Aged; D001682:Biological Availability; D003327:Coronary Disease / Q000097:blood; D004077:Digoxin / Q000008:administration & dosage / Q000097:blood*; D006333:Heart Failure / Q000097:blood*; D006801:Humans; D008297:Male; D012214:Rheumatic Heart Disease / Q000097:blood; D013607:Tablets; D013810:Therapeutic Equivalency; D013997:Time Factors
D013607:Tablets; D004077:Digoxin
Biodostupnost' tabletok digoksina u bol'nykh serdechnoĭ nedostatochnost'iu.