[Paroxystic hypertension after ingestion of gruyere cheese during isoniazide treatment: a report on two cases (author's transl)].
Paroxystic hypertension was observed in two patients receiving isoniazide treatment, after they had ingested gruyere cheese. It is highly probable that isoniazide was responsible, as hypertension did not reoccur under the same conditions after interrupting treatment. One patient developed a vasomotor reaction identical to that which sometimes occurs after the eating of foods rich in tyramine by patients taking monoamine oxydase inhibitors. It could be that in our patients this phenomenon was consecutive to the inhibition of plasma monoamine oxydase by the isoniazide. It was not due to an overdose of isoniazide. This unusual reaction suggest that patients taking isoniazide should be questioned whether they have had post-prandial vasomotor flushes, and if so, advised to avoid foods rich in tyramine.
D000328:Adult; D002611:Cheese / Q000009:adverse effects*; D006801:Humans; D006973:Hypertension / Q000139:chemically induced*; D007538:Isoniazid / Q000009:adverse effects* / Q000494:pharmacology; D008297:Male; D008995:Monoamine Oxidase / Q000097:blood; D008996:Monoamine Oxidase Inhibitors; D014439:Tyramine / Q000009:adverse effects
D008996:Monoamine Oxidase Inhibitors; D008995:Monoamine Oxidase; D007538:Isoniazid; D014439:Tyramine
Hypertension artérielle paroxystique provoquée sous isoniazide par l'ingestion de gruyère: deux cas.