Glutathione peroxidase activity in various types of blood cells in multiple sclerosis.
Previous studies demonstrated a significantly lower mean activity of glutathione peroxidase (GSH-Px) in erythrocytes of patients with multiple sclerosis than in control groups of normal subjects or patients with various neurological disorders. The present investigation has demonstrated that, in contradistinction to erythrocytes, a normal activity of GSH-Px is found in lymphocytes, granulocytes and platelets of multiple sclerosis patients. These results were obtained both with hydrogen peroxide, which serves as a specific substrate for selenium dependent GSH-Px, and t-butyl hydroperoxide which reacts both with selenium dependent and independent GSH-Px.
D001773:Blood Cells / Q000201:enzymology*; D005979:Glutathione Peroxidase / Q000097:blood* / Q000235:genetics; D006801:Humans; D009103:Multiple Sclerosis / Q000097:blood / Q000201:enzymology*; D010544:Peroxidases / Q000097:blood*; D011110:Polymorphism, Genetic; D012643:Selenium / Q000172:deficiency
D010544:Peroxidases; D005979:Glutathione Peroxidase; D012643:Selenium