Renal toxicity of aspirin to rats pre-treated with ethinyl oestradiol.
Castrated rats receiving aspirin at a dose level of 1000 mg/kg showed necrosis of the proximal convoluted tubules, similar to that seen in female rats, and the extent of this lesion was increased by oestrogen pre-treatment. Urinary gamma-glutamyl transpeptidase activity was a useful indicator of the necrotic changes induced.
D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D002369:Castration; D004997:Ethinyl Estradiol / Q000494:pharmacology; D005260:Female; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D008297:Male; D051381:Rats; D014556:Urine / Q000032:analysis
D004997:Ethinyl Estradiol; D001241:Aspirin