Age-dependent sensitivity of the rat to neurotoxic effects of streptomycin.
Streptomycin sulfate (300 mg/kg s.c.) was injected for various periods into preweanling rats and for 3 weeks into weanling rats. Beginning at 8 days of age, body movement and hearing were examined for 6 and up to 17 weeks, respectively. Abnormal movements and deafness occurred only in rats treated during the preweaning period; within this period the greatest sensitivities for these abnormalities occurred from 2 to 11-17 and 5 to 11 days of age, respectively, indicating that the cochlea is more sensitive to streptomycin than the site (vestibular or central) responsible for the dyskinesias.
D000367:Age Factors; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D003638:Deafness / Q000139:chemically induced*; D004409:Dyskinesia, Drug-Induced / Q000209:etiology*; D007758:Ear, Inner / Q000187:drug effects / Q000473:pathology; D005260:Female; D008297:Male; D051381:Rats; D013307:Streptomycin / Q000633:toxicity*
D013307:Streptomycin