title: Electrodermal activity in depression: clinical and biochemical correlates.
abstract: Electrodermal activity was measured in a group of depressive patients and normal controls. Those patients classified as endogenous on the Newcastle Scale had significantly lower skin conductance levels than either the non-endogenous patients or controls. The endogenous depressives also contained significantly more non-responders to the experimental stimuli. The lack of responsiveness to external stimulation in non-responders is associated with a significantly lower rate of blood platelet 5-hydroxytryptamine uptake, suggesting that endogenous depressives have biological characteristics that distinguish them from other depressive groups and that electrodermal measures may be useful in the classification of depressive illness.
mesh_terms: D001792:Blood Platelets / Q000378:metabolism; D003863:Depression / Q000097:blood / Q000503:physiopathology*; D005260:Female; D005712:Galvanic Skin Response; D006185:Habituation, Psychophysiologic / Q000502:physiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D012701:Serotonin / Q000097:blood; D012867:Skin / Q000503:physiopathology*
chemical_list: D012701:Serotonin