Improved diagnosis of pregnancy-related gynaecological emergencies by rapid human chorionic gonadotrophin beta-subunit assay.
A pregnancy-related disorder was identified by a rapid radioimmunoassay of serum chorionic gonadotrophin (hCG-RIA) in 122 out of 470 women (26 per cent) with lower abdominal pain or bleeding, while a routine pregnancy test in urine was positive in only 7 per cent of these cases. In 49 patients with ectopic pregnancy the rapid hCG-RIA was positive in 90 per cent as compared with 13 per cent for the routine pregnancy test. In patients with evidence of intrauterine pregnancy (66 cases) the rapid hCG-RIA was positive in 98 per cent and the routine pregnancy test in 38 per cent. The clinical sensitivity of the hCG-RIA was 95 per cent, specificity 96 per cent and predictive value 89 per cent. The test can improve the efficiency of the routine diagnosis of early intra- and extrauterine pregnancy-related disorders.
D006063:Chorionic Gonadotropin / Q000097:blood* / Q000652:urine; D004630:Emergencies; D005260:Female; D005831:Genital Diseases, Female / Q000175:diagnosis*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications / Q000175:diagnosis*; D011259:Pregnancy Tests, Immunologic; D011863:Radioimmunoassay; D014592:Uterine Hemorrhage / Q000175:diagnosis
D006063:Chorionic Gonadotropin