The fine structure of neurofibrillary tangles in a case of atypical presenile dementia.
The neurofibrillary tangles in a case of atypical presenile dementia were studied by electron microscopy. The tangles consisted of 2 types of tubule: one straight, measuring about 15--20 nm in width, the other twisted. Both types of tubule appeared separately in each neuron; however, occasionally twisted tubules seemed to be distributed among the straight tubules. The implications of these findings are briefly discussed.
D000425:Alcohol Amnestic Disorder / Q000473:pathology; D003704:Dementia / Q000473:pathology*; D005260:Female; D005625:Frontal Lobe / Q000473:pathology; D006624:Hippocampus / Q000473:pathology; D006801:Humans; D008870:Microtubules / Q000648:ultrastructure; D008875:Middle Aged; D009454:Neurofibrils / Q000648:ultrastructure*; D009474:Neurons / Q000648:ultrastructure