[Pharmacological properties of indolylalkyl derivatives of quipazine].
Pharmacological activity of the indolylalkyl derivatives of quipazin has been studied. 1-3(-Indolylmethyl)-4-(2"-quinolyl) piperazine dimaleate has proved to be the most active according to the tests used for examining the properties of quipazin. Like quipazin, it produces the contracture of smooth muscle organs and bronchospasm. It has a constrictive effect of the vessels, elicits central serotonin-positive actions, reduces the effect of reserpine and tetrabenazine, potentiates the central effects of amphetamine and L-DOPA. The drug does not affect the convulsant action of tryptamine in rats. Unlike imipramine, it shows no cholinolytic activity. Elongation of the methylene chain that connects the indole residue and the quipazin molecule leads to a decrease in the pharmacological activity.
D000818:Animals; D002415:Cats; D004305:Dose-Response Relationship, Drug; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D006168:Guinea Pigs; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008995:Monoamine Oxidase / Q000378:metabolism; D011804:Quinolines / Q000494:pharmacology*; D011814:Quipazine / Q000031:analogs & derivatives / Q000494:pharmacology* / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D011941:Receptors, Adrenergic / Q000187:drug effects; D011950:Receptors, Cholinergic / Q000187:drug effects; D011954:Receptors, Dopamine / Q000187:drug effects; D011985:Receptors, Serotonin / Q000187:drug effects; D013329:Structure-Activity Relationship
D011804:Quinolines; D011941:Receptors, Adrenergic; D011950:Receptors, Cholinergic; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D011814:Quipazine; D008995:Monoamine Oxidase
Farmakologicheskie svoĭstva nekotorykh indolilakil'nykh proizvodnykh kvipazina.