Heparin, free fatty acids and an increased metabolic demand for oxygen.
Obese and lean subjects were given heparin with or without Intralipid in order to assess the effect of heparin on plasma concentration of free fatty acids (FFA) and oxidative metabolism. The FFA response depended on the triglyceride concentration and was associated with a prompt rise in oxygen consumption. Plasma catecholamines did not alter after heparin and the increase in oxygen uptake was proportional to the rise in FFA. The use of heparin, therefore, has metabolic disadvantages which may outweigh the potential benefits, for example in the management of myocardial infarction where heparin may increase the metabolic demand on the heart by increasing FFA levels.
D000328:Adult; D005217:Fat Emulsions, Intravenous / Q000494:pharmacology; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D006493:Heparin / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D008875:Middle Aged; D009765:Obesity / Q000097:blood / Q000378:metabolism; D010101:Oxygen Consumption / Q000187:drug effects*; D013268:Stimulation, Chemical; D014280:Triglycerides / Q000097:blood
D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D006493:Heparin