[Diaplacental inhibition of fetal blood coagulation in pregnant sheep (author's transl)].
We investigated the effect of the synthetic low-molecular thrombin inhibitor 4-amidinophenyl-pyruvic acid (APPA) on the maternal and fetal coagulation at 10 far advanced in pregnancy sheep. APPA inhibits as well the maternal as by diaplacental passage the fetal hemostasis in dependence on the dosage till the incoagulability. The effect in the fetal organism occurs after a delay of some minutes and wars of a bit earlier.
D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D005260:Female; D005312:Fetal Blood / Q000187:drug effects*; D008431:Maternal-Fetal Exchange; D010667:Phenylpyruvic Acids / Q000494:pharmacology*; D011247:Pregnancy; D012756:Sheep; D013916:Thrombelastography; D013918:Thrombin Time
D010667:Phenylpyruvic Acids; C006492:amidinophenylpyruvic acid; C028615:ethyl 4-amidinophenylpyruvate; D004121:Dimethyl Sulfoxide
Die diaplazentare Hemmung der fetalen Blutgerinnung am trächtigen Schaf.