Modulation oestradiol effects by silver nitrate: inhibition of the adenohypophyseal reaction, block of the ceruloplasmin increase and block of hypothalamic ascorbic acid depletion.
Chronic oestradiol treatment (1 mg oestradiol benzoate, as an aqueous microcrystal suspension, i.m. twice a week for 6 weeks) produces in rats increased thyroxine-binding capacity of the adenohypophyseal proteins in vitro, an increase in the ceruloplasmin (polyphenol oxidase) level in blood and a decrease in the hypothalamic ascorbic acid concentration. The simultaneous administration of silver nitrate (10mg/rat/day in food) inhibits all these reactions in oestradiol. Apart from inhibiting blood polyphenol oxidase activity, silver nitrate itself has no effect. The possibility of the interaction of polyphenol oxidase(ceruloplasmin), silver nitrate and hypothalamic ascorbic acid in the dopaminergic modulation of the adenohypophyseal reaction to oestradiol is discussed.
D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D002570:Ceruloplasmin / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D007031:Hypothalamus / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D010903:Pituitary Gland, Anterior / Q000187:drug effects* / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D012835:Silver Nitrate / Q000494:pharmacology*; D013974:Thyroxine / Q000378:metabolism
D011506:Proteins; D004958:Estradiol; D012835:Silver Nitrate; D002570:Ceruloplasmin; D001205:Ascorbic Acid; D013974:Thyroxine