Tumour sublines with different metastatic capacity induce similar blood coagulation changes in the host.
This paper is aimed at investigating how metastatic tumour growth influenced the haemostatic system of the host. Blood platelet count, blood fibrinogen level, the activated partial thromboplastin time (APTT) and the prothrombin time (PT) were determined at various intervals during growth and metastasis of a murine fibrosarcoma (mFS6) or one of its sublines with different metastatic capacity. Progressive thrombocytopenia and increase in fibrinogen level were observed during development of the tumour in all the animal groups studied, irrespective of the metastatic potential of the various sublines. No significant changes were observed in the PT or APTT values. These data support the concept that primary rather than metastatic growth influences the haemostatic system of tumour-bearing animals.
D000818:Animals; D001777:Blood Coagulation; D002460:Cell Line; D005340:Fibrinogen / Q000032:analysis; D005354:Fibrosarcoma / Q000097:blood / Q000556:secondary*; D008175:Lung Neoplasms / Q000097:blood / Q000556:secondary*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D011517:Prothrombin Time; D012513:Sarcoma, Experimental / Q000097:blood / Q000556:secondary
D005340:Fibrinogen