title: gamma-Carboxyglutamic acid-containing protein of rat kidney cortex. Changes with high fat diet, and molecular parameters.
abstract: It was shown that the level of gamma-carboxyglutamic acid-containing protein is increased in perfused rat kidney after long-term administration (60 and 350 days) of a high-fat diet. No difference was found between the effect of vegetable fat and animal fat. Concomitantly it was shown that the relative molecular weight, N-terminal sequence over four residues, the profile of chymotryptic peptides and the sequence around the two (of the three in total) gamma-carboxyglutamic acid residues (over the span of seven residues) are identical with those found previously in osteocalcin and the gamma-carboxyglutamic acid-containing protein isolated from at least partially calcified connective tissue.
mesh_terms: D015055:1-Carboxyglutamic Acid / Q000378:metabolism*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D005269:Femur / Q000378:metabolism; D005971:Glutamates / Q000378:metabolism*; D007672:Kidney Cortex / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008297:Male; D008861:Microsomes / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D051381:Rats
chemical_list: D000596:Amino Acids; D004041:Dietary Fats; D005971:Glutamates; D011506:Proteins; D015055:1-Carboxyglutamic Acid