Estrogenic absorption through the skin: an experimental study.
Our results show in an unquestionable way that both the steroid (ethinylestradiol) and non-steroid (Ralone) estrogens studied by us were absorbed percutaneously by the rat. They also demonstrate that both estrogens affected target organs in a quite similar way being proportionally dependent upon the 1-to-1,000 ratio existing between them, as established on the basis of a known activity parameter. When one of the two estrogens is given for therapeutical purposes its systemic effects are of a dose-related type.
D000818:Animals; D001835:Body Weight; D002369:Castration; D004717:Endometrium / Q000187:drug effects; D004997:Ethinyl Estradiol / Q000378:metabolism*; D005260:Female; D005836:Genitalia, Female / Q000166:cytology; D009929:Organ Size; D051381:Rats; D012118:Resorcinols / Q000378:metabolism*; D012869:Skin Absorption; D014018:Tissue Distribution; D014621:Vagina / Q000166:cytology / Q000187:drug effects; D015029:Zeranol / Q000378:metabolism*
D012118:Resorcinols; D004997:Ethinyl Estradiol; D015029:Zeranol