title: Mechanism for gastric accumulation of meperidine and effect of antacid.
abstract: The effect of hydrogen ion activity (pH) on the degree of meperidine sequestration in gastric contents was studied in 15 patients. Those patients with higher gastric juice cH+ (lower pH) showed greater accumulation with time. At a cH+ more than 10,000 nmol/l, (pH < 5) concentration usually reached 100 micrograms/ml within the 60-minute period after administration of 200 mg of meperidine. When cH+ was less than 100 nmol/l (pH > 7) gastric concentrations remained low, being only slightly greater than those of plasma. Oral administration of antacid may be a practical method for preventing sequestration of meperidine in gastric juice.
mesh_terms: D000328:Adult; D000368:Aged; D000863:Antacids / Q000494:pharmacology*; D005260:Female; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D008297:Male; D008614:Meperidine / Q000378:metabolism*; D008875:Middle Aged
chemical_list: D000863:Antacids; D008614:Meperidine