New anticoccidial antibiotics, WS-5995 A and B. I. Isolation and characterization.
WS-5995 A, B and C are produced by a new strain of Streptomyces designated Streptomyces auranticolor. These antibiotics were purified by solvent extraction followed by chromatography on silica gel and then crystallized. WS-5995 A (C19H12O6, m.p., 289 approximately 291 degrees C) and WS-5995 B (C19H14O6, sublimation at 300 degrees C) protect chickens from infection with Eimeria tenella, a species of coccidia, which produces morbidity or mortality in chickens. WS-5995 C (C19H14O 7, m.p. 288 approximately 290 degrees C), a biologically inactive component, was found to be converted to WS-5995 A on treatment with trifluoroacetic anhydride.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003048:Coccidiosis / Q000188:drug therapy; D003049:Coccidiostats / Q000378:metabolism* / Q000494:pharmacology; D003374:Coumarins / Q000096:biosynthesis / Q000494:pharmacology; D005285:Fermentation; D051379:Mice; D008985:Monensin / Q000627:therapeutic use; D009285:Naphthoquinones / Q000096:biosynthesis / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism
D000900:Anti-Bacterial Agents; D003049:Coccidiostats; D003374:Coumarins; D009285:Naphthoquinones; C027838:WS-5995 A; C027839:WS-5995 B; D008985:Monensin