title: Amiodarone-induced thyrotoxicosis: four cases and a review of the literature.
abstract: Hyperthyroidism is a rare side effect of amiodarone treatment. Four patients with this untoward effect are described One patient with mild hyperthyroidism before treatment with amiodarone, developed prolonged severe resistant thyrotoxicosis 6 months after initiation of this drug. A second patient with Wolf-Parkinson-White syndrome and paroxysmal atrial fibrillation was successfully stabilized with amiodarone for 18 months. However, the arrhythmia recurred and the thyroid function tests were found to be elevated. In 2 other patients only slight elevation of the thyroid function tests were found without clinical manifestations 4 months after treatment with amiodarone had been initiated.
mesh_terms: D000368:Aged; D000638:Amiodarone / Q000009:adverse effects*; D001572:Benzofurans / Q000009:adverse effects*; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced*; D008297:Male; D008875:Middle Aged
chemical_list: D001572:Benzofurans; D000638:Amiodarone