[Preliminary study of acidification of the pH of the aqueous humor in rats treated with timolol maleate].
The Authors have studied in a homogeneous group of rabbits the variations of intraocular pressure and of aqueous humour pH caused by instillation of timolol maleate at different concentrations. In the animals treated with drug concentration of 0,25% and 0,5% a constant reduction of IOP has been observed in comparison with controls, associated to acidification of aqueous humour: no evidence of this correlation it seems to be at low doses of timolol. Further studies are in course to indicate an eventual action of intermediate substances in the mechanism of IOP depression caused by timolol.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000818:Animals; D001082:Aqueous Humor / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006863:Hydrogen-Ion Concentration; D007429:Intraocular Pressure / Q000187:drug effects*; D011412:Propanolamines / Q000494:pharmacology*; D011817:Rabbits; D013999:Timolol / Q000494:pharmacology*
D011412:Propanolamines; D013999:Timolol
Studio preliminare sull'acidificazione del ph dell'umore acqueo del coniglio trattato con timololo maleato.