ABO blood groups and coronary heart disease (CHD). A study in subjects with severe and latent CHD.
The view based on epidemiological and laboratory data that blood group A subjects (=A) have clinically significant higher thrombotic potential than blood group 0 subjects (=O), is supported by the present finding of a significantly higher platelet retention in A than 0. The completely normal AB0 distribution found among 71 cases of proven latent CHD, and the disproportionate excess of 0 vs. A in a consecutive series of 191 coronary artery bypass candidates apparently conflict with epidemiological data indicating a higher risk of achieving CHD in A than 0. The conflict may be solved by suggesting a) that the "thrombotic proneness" in A compared with 0 causes a poorer prognosis in CHD among the former, leaving a disproportionate excess of 0 among longterm CHD survivors, and b) that AB0-related factors have had an insignificant, independent impact on the evolution of preclinical coronary artery disease in our 71 men with latent CHD.
D000017:ABO Blood-Group System / Q000235:genetics*; D000328:Adult; D000792:Angiography; D001158:Arteries / Q000601:surgery; D001792:Blood Platelets; D003327:Coronary Disease / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000502:physiology; D008297:Male; D008875:Middle Aged
D000017:ABO Blood-Group System; D008055:Lipids