Toxicity of butylbenzyl phthalate (BBP) and other phthalate esters to nervous tissue in culture.
Butylbenzyl phthalate (BBP) and n-butyl lauryl phthalate (BLP) markedly inhibited the outgrowth of nerve fibers and glial cells from cerebellar explants of newborn rat in primary culture at concentrations of 7.0 and 12.5 x 10(-4) M, respectively. The toxicity of butyl phthalyl butyl glycolate (BPBG) was not significant. From these results the order of toxicity of these three phthalate esters was determined as BBP > BLP > BPBG.
D000818:Animals; D002490:Central Nervous System / Q000187:drug effects; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D008970:Molecular Weight; D009412:Nerve Fibers / Q000187:drug effects*; D009457:Neuroglia / Q000187:drug effects*; D010795:Phthalic Acids / Q000633:toxicity*; D051381:Rats; D012995:Solubility
D010795:Phthalic Acids; C027561:butylbenzyl phthalate