HBsAg-positive giant cell hepatitis with cirrhosis in a 10-month-old infant.
A Japanese boy, who was born to an asymptomatic HBsAg and HBeAg carrier mother, developed acute type B hepatitis at age 6 months. Hepatosplenomegaly and abnormal liver function tests persisted. Liver biopsy at 10 months showed giant cell hepatitis with cirrhosis. He was given alternate-day therapy with prednisolone for 7 months. HBsAg was detectable from ages 6 to 19 months, but not after. Anti-HBs and anti-HBe were not present at any time.
D000328:Adult; D002353:Carrier State; D005260:Female; D006509:Hepatitis B / Q000150:complications* / Q000276:immunology / Q000635:transmission; D006514:Hepatitis B Surface Antigens / Q000032:analysis; D006801:Humans; D007223:Infant; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D006514:Hepatitis B Surface Antigens