title: Effect of a cholecystokinin preparation on brain monoamines in the rat.
abstract: In order to elucidate the central action mechanism of cholecystokinin (CCK), effects of this peptide on norepinephrine, dopamine and serotonin contents in the brain were observed in saline control, alpha-methyl-p-tyrosine-, L-DOPA- and pargyline-pretreated rats. Intraperitoneal injection of CCK in a dose of 40 U/kg did not produce any significant changes in the monoamine contents. However, since a tendency to increase in norepinephrine turnover rate after CCK injection was noticed, the possibility that brain monoamines are involved in the central action of CCK could not be excluded.
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D002766:Cholecystokinin / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007980:Levodopa / Q000494:pharmacology; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism*; D010293:Pargyline / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*
chemical_list: D008781:Methyltyrosines; D012701:Serotonin; D007980:Levodopa; D002766:Cholecystokinin; D010293:Pargyline; D004298:Dopamine; D009638:Norepinephrine