Effect of indomethacin and naproxen on collagen cross-linking.
The influence of indomethacin and naproxen on rat dermal collagen cross-linking was investigated in vivo. The analyses of skins showed that the naproxen group had a decrease in percent reversibility of neutral salt-soluble collagen gel, susceptibility of insoluble collagen to denaturing agents and pronase and alpha/beta ratio of neutral salt-soluble collagen whereas the aldehyde content was significantly increased. Indomethacin was ineffective for all these parameters. The results indicated that both the inter and intra-molecular cross-linking of collagen was increased in the naproxen treated group while indomethacin did not influence the collagen cross-linking.
D000447:Aldehydes / Q000032:analysis; D000818:Animals; D003094:Collagen / Q000378:metabolism*; D007213:Indomethacin / Q000494:pharmacology*; D046911:Macromolecular Substances; D008297:Male; D009288:Naproxen / Q000494:pharmacology*; D051381:Rats; D012867:Skin / Q000187:drug effects* / Q000378:metabolism; D012995:Solubility
D000447:Aldehydes; D046911:Macromolecular Substances; D009288:Naproxen; D003094:Collagen; D007213:Indomethacin