Plasma lipoproteins in maturity onset diabetes.
Plasma lipoprotein abnormalities in maturity onset diabetes (MOD) reflect both enhanced production and impaired removal of triglyceride-rich lipoproteins. Hyperglycemia and hyperinsulinemia lead to overproduction of very-low density lipoproteins by the liver. Fat tolerance is reduced in MOD patients: this might be due to low lipoprotein lipase activity (LLA) and/or to low incorporation of LLA-released fatty acids into adipose tissue glyceride. This finding of abnormal low-density lipoprotein composition, with relative enrichment in triglyceride, suggests remnant particle accumulation.
D000328:Adult; D002784:Cholesterol / Q000097:blood; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000209:etiology* / Q000378:metabolism; D008071:Lipoprotein Lipase / Q000378:metabolism; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000378:metabolism
D008074:Lipoproteins; D014280:Triglycerides; D002784:Cholesterol; D008071:Lipoprotein Lipase