Anaphylactic reactions to Hymenoptera stings in asthmatic patients.
We evaluated 587 cases with generalized reactions to stings of Hymenoptera. Eighty of these patients and twenty-eight normal controls had radioallergosorbent tests (RAST) to venoms of honey bee, yellow jacket, hornet, wasp and to phospholipase A. Those patients with systemic reactions had a significantly greater frequency of positive RAST than normal controls (51.3% vs. 7.1%, P < 0.001). The frequency of atopy (asthma/rhinitis) in case these 587 cases was only 22% and resembled the expected frequency in a general population. Asthmatic patients did not have an increased risk of developing systemic reactions to Hymenoptera stings. However, those asthmatic patients with systemic reactions to Hymenoptera stings had a significantly more severe anaphylactic reaction to a sting than non-asthmatics. These severe reactions were primarily manifested by acute dyspnoea, which appeared to represent a bronchospastic response to endogenous histamine release.
D000707:Anaphylaxis / Q000150:complications*; D001249:Asthma / Q000150:complications*; D002648:Child; D004417:Dyspnea / Q000150:complications; D005260:Female; D006801:Humans; D006927:Hymenoptera; D006969:Hypersensitivity, Immediate / Q000150:complications; D007299:Insect Bites and Stings / Q000150:complications*; D008297:Male; D012220:Rhinitis / Q000150:complications; D014581:Urticaria / Q000150:complications