title: The toxicity of the non-ionic water-soluble contrast media iohexol and metrizamide (Amipaque) in selective vertebral angiography. An experimental study in rabbits.
abstract: Selective left vertebral angiography was carried out in 25 rabbits comparing the toxic effects of iohexol and metrizamide (Amipaque). The iodine concentration for iohexol was 280 and 350 mg/ml and for metrizamide 350 mg/ml. Short general convulsions were seen in many of the animals with iohexol in the concentration of 350 mg iodine/ml. Cardiovascular reactions were seen with both contrast media, but were more marked with iohexol than with metrizamide in the concentration of 350 mg iodine/ml. Both iohexol and metrizamide are far less toxic than the ionic contrast medium metrizoate, but metrizamide seems to be less toxic than iohexol in vertebral angiography.
mesh_terms: D000818:Animals; D001919:Bradycardia / Q000139:chemically induced; D003287:Contrast Media / Q000633:toxicity*; D005260:Female; D007463:Iodobenzoates / Q000633:toxicity*; D007472:Iohexol; D008297:Male; D008793:Metrizamide / Q000633:toxicity*; D010243:Paralysis / Q000139:chemically induced; D011817:Rabbits; D011859:Radiography; D012640:Seizures / Q000139:chemically induced; D013131:Spine / Q000000981:diagnostic imaging*; D014283:Triiodobenzoic Acids / Q000633:toxicity*
chemical_list: D003287:Contrast Media; D007463:Iodobenzoates; D014283:Triiodobenzoic Acids; D007472:Iohexol; D008793:Metrizamide