In situ aging of auricular chondrocytes is not due to the exhaustion of their replicative potential.
Multiplication of chondrocytes during growth of rabbit auricular cartilage was estimated on the basis of total DNA determination and compared with the population doubling level reached by these chondrocytes in vitro. The results indicate that the in situ aging of auricular chondrocytes is caused by factors other than the intrinsic depletion of their growth potential.
D000375:Aging; D000818:Animals; D000831:Animals, Newborn; D002356:Cartilage / Q000254:growth & development*; D002455:Cell Division; D004247:DNA / Q000378:metabolism; D004423:Ear; D011817:Rabbits
D004247:DNA