[Functional role of noradrenergic neurons in the hypothermic effect of apomorphine and other dopaminomimetics].
Administration of 6-hydroxydopamine hydrobromide (20-50 mg) into the cerebral ventricles of mice products the depletion of noradrenaline and dopamine in the brain and counteracts the hypothermic effect of dopaminomimetic drugs of direct (apomorphine, piribedil, bromocryptin, CM29-712) and indirect (d, l-amphetamine, L-DOPA) type of action. Pretreatment of animals with the blockers of catecholamines noradrenergic neuronal uptake (desipramine, protryptyline and AW15(1)II29) counteracts both the depletion of noradrenaline in the brain and the antihypothermic effect of 6-hydroxydopamine. The experimental data support the noradrenergic involvement in the hypothermic effect of dopaminomimetics in mice.
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology*; D001831:Body Temperature / Q000187:drug effects; D004298:Dopamine / Q000031:analogs & derivatives*; D005260:Female; D006892:Hydroxydopamines / Q000494:pharmacology; D007035:Hypothermia / Q000139:chemically induced*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009474:Neurons / Q000187:drug effects*; D009638:Norepinephrine / Q000502:physiology*; D011941:Receptors, Adrenergic / Q000187:drug effects*; D013566:Sympathomimetics / Q000494:pharmacology*; D013997:Time Factors
D006892:Hydroxydopamines; D011941:Receptors, Adrenergic; D013566:Sympathomimetics; D001058:Apomorphine; D004298:Dopamine; D009638:Norepinephrine
Funktsional'naia rol' noradrenergicheskikh neĭronov v gipotermicheskom éffekte apomorfina i drugikh dofaminomimetikov.