[Prevention of the unwanted action of hydrocortisone on the growth and development of rat pups with cholinolytic preparations].
Experiments on young rats have shown that diplacin and d-tubocurarine in doses amounting to 1/15-1/20 of LD50 lower the ability of hydrocortisone to interfere with the physical development of the animals. Metamisyl, metacin, gangleron and benzohexonium have no such properties. In adult rats and guinea-pigs, diplacin exerts no effect on the intensity of anti-inflammatory and antiallergic action of the hormonal drug, while d-tubocurarine diminishes the anti-inflammatory effect of the corticosteroid in experimental formalin-induced paw edema and weakens its effect on the immediate type hypersensitivity.
D000818:Animals; D000893:Anti-Inflammatory Agents; D001835:Body Weight / Q000187:drug effects; D004347:Drug Interactions; D006128:Growth / Q000187:drug effects*; D006168:Guinea Pigs; D006854:Hydrocortisone / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D006967:Hypersensitivity / Q000188:drug therapy; D008297:Male; D009125:Muscle Relaxants, Central / Q000494:pharmacology; D010276:Parasympatholytics / Q000494:pharmacology*; D051381:Rats; D013997:Time Factors
D000893:Anti-Inflammatory Agents; D009125:Muscle Relaxants, Central; D010276:Parasympatholytics; D006854:Hydrocortisone
Preduprezhdenie kholinoliticheskimi preparatami nezhelatel'nogo deĭstviia gidrokortizona na rost i razvitie krysiat.