Development of antisickling compounds that chemically modify hemoglobin S specifically within the 2,3-diphosphoglycerate binding site.
D000345:Affinity Labels / Q000494:pharmacology; D000986:Antisickling Agents / Q000494:pharmacology*; D001241:Aspirin / Q000031:analogs & derivatives* / Q000494:pharmacology; D001665:Binding Sites; D001704:Biopolymers; D004163:Diphosphoglyceric Acids; D004591:Electrophoresis, Polyacrylamide Gel; D005650:Fumarates / Q000494:pharmacology; D006451:Hemoglobin, Sickle; D007525:Isoelectric Focusing; D010100:Oxygen / Q000097:blood; D012995:Solubility; D013386:Succinates / Q000494:pharmacology; D014961:X-Ray Diffraction
D000345:Affinity Labels; D000986:Antisickling Agents; D001704:Biopolymers; D004163:Diphosphoglyceric Acids; D005650:Fumarates; D006451:Hemoglobin, Sickle; D013386:Succinates; D001241:Aspirin; D010100:Oxygen