Effects of antibiotics on platelet functions in human plasma in vitro and dog plasma in vivo.
The effects of 31 antibiotics on platelet aggregation in human plasma in the presence of adenosine 5'-diphosphate were studied. The marked activity of tetracycline hydrochloride led to a study of its effects on various platelet functions in vivo in dogs.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001792:Blood Platelets / Q000187:drug effects; D004285:Dogs; D006801:Humans; D066298:In Vitro Techniques; D010974:Platelet Aggregation / Q000187:drug effects*; D013752:Tetracycline / Q000494:pharmacology; D013997:Time Factors
D000900:Anti-Bacterial Agents; D013752:Tetracycline