Bioavailability and multiple dose characteristics of a new sustained release theophylline tablet.
Bioavailability and theophylline level variability were compared between a standard theophylline elixir and a new sustained release theophylline tablet. The results demonstrate a good bioavailability and a reduced dosage interval with less theophylline level variability for the sustained release tablet, administered every 12 hours, than with the immediate release product, every six hours.
D000328:Adult; D001682:Biological Availability; D004305:Dose-Response Relationship, Drug; D006801:Humans; D013806:Theophylline / Q000009:adverse effects / Q000378:metabolism*; D013997:Time Factors
D013806:Theophylline