Chromosomal aberrations in peripheral lymphocytes of alcoholics.
The frequencies of exchange-type aberrations found in peripheral lymphocytes of alcoholics were analysed in relation to age, sex, duration of alcohol dependency, treatment with antabuse and smoking habit. The statistical analyses were performed by the non-parametric Mann-Whitney U test and the Kruskal-Wallis 1-way analysis of variance, both at a level of significance of P = 0.05. There was no dependency on age or sex. The chromatid exchange frequencies and the total of all exchanges were positively correlated with the duration of the dependency on alcohol and with smoking habit. Treatment with antabuse did not lead to an additional elevation of the frequency of exchange-type aberrations.
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000437:Alcoholism / Q000188:drug therapy / Q000235:genetics*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003434:Crossing Over, Genetic; D004221:Disulfiram / Q000627:therapeutic use; D005260:Female; D005787:Gene Frequency; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D012737:Sex Factors; D012854:Sister Chromatid Exchange; D012907:Smoking; D013997:Time Factors
D004221:Disulfiram