[Liver damage after paracetamol and carbon tetrachloride administration].
Preliminary data on the liver damage following combined treatment with paracetamol and carbon tetrachloride in the rat are reported. Administration of a single dose of paracetamol (2000 mg/kg, os) was followed after 1 hour by an intraperitoneal injection of CCl4 (1.0 ml/Kg). Experiments in parallel were performed in rat given paracetamol or CCl4 alone. Our results indicate paracetamol induces a drastic decrease of hepatic GSH that appears in relation with a marked production of TBA-reacting compounds in liver tissue, while CCl4 does not modify the hepatic content of GSH and provokes a slight increase of TBA-reacting substances. Preventive treatment with paracetamol of rats intoxicated after 1 hour with carbon tetrachloride results in a partial protection against fatty liver and necrosis following haloalkane poisoning. On the other hand, the combined treatment with both the hepatotoxins was followed by a minor decrease of GSH. These data are discussed in considering a possible interaction of the two chemicals at the site of their activation.
D000082:Acetaminophen / Q000627:therapeutic use*; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology* / Q000517:prevention & control; D055598:Chemical Phenomena; D002621:Chemistry; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D051381:Rats; D013858:Thiobarbiturates; D014280:Triglycerides / Q000378:metabolism
D013858:Thiobarbiturates; D014280:Triglycerides; D000082:Acetaminophen; D000410:Alanine Transaminase; D005978:Glutathione
Osservazioni sperimentali sul danno epatico conseguente alla somministrazione di paracetamolo e tetracloruro di carbonio.