[Gastric acidity induced by cimetidine. Evaluation during general anaesthesia (author's transl)].
400 mg of cimetidine were administered intramuscularly 60 minutes before the beginning of general anesthesia. The double blind experiment was conducted on 84 patients divided in two groups: cimetidine and control. As far as the gastric fluid volumes are concerned there was no difference between the two groups during general anesthesia, but acid secretion decreased significantly in the cimetidine group, pH values lower than 2.5 were observed in 33.3 p. cent at induction time and 34 p. cent at recovery time in the control group against 14.6 p. cent and 0 p. cent in the cimetidine group.
D000768:Anesthesia, General; D002927:Cimetidine / Q000494:pharmacology; D004311:Double-Blind Method; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005745:Gastric Acidity Determination; D006146:Guanidines; D006801:Humans; D008297:Male; D008875:Middle Aged; D011229:Preanesthetic Medication
D006146:Guanidines; D002927:Cimetidine
Contrôle de l'acidité gastrique par la cimétidine au cours de l'anesthésie générale.