17 beta-estradiol levels in blood and cerebrospinal fluid after ocular and nasal administration in women and female rhesus monkeys (Macaca mulatta).
17 beta-estradiol was applied ocularly to menstruating and postmenopausal women. The absorption by blood was measured. A rapid increase of both estradiol and estrone was seen with higher plasma levels in the menstruating group, possibly due to a better conjunctival circulation. Twenty-one rhesus monkeys were given estradiol suspension or solution ocularly or nasally. The absorption by blood and cerebrospinal fluid was measured and compared to intravenous injection of 0.5 mg estradiol. Estradiol increased in plasma after 1'. Maxima were reached at 15'. Estradiol solution gave higher plasma levels than estradiol suspension. At 5' they amounted to the levels found after i.v. injection. The estradiol levels in cerebrospinal fluid never exceeded the corresponding plasma levels and were generally low. The increase in cerebrospinal fluid was thought to be secondary to the raised plasma levels.
D000281:Administration, Intranasal; D000818:Animals; D004958:Estradiol / Q000097:blood* / Q000134:cerebrospinal fluid; D004970:Estrone / Q000097:blood; D005123:Eye; D005260:Female; D006801:Humans; D008253:Macaca mulatta
D004970:Estrone; D004958:Estradiol