[The effect of aminophylline (Euphyllin) on the mechanics of breathing and the gaseous exchange in persons with bronchial asthma (author's transl)].
The physiological effect of intravenous application of aminophylline on the mechanics of breathing and the gaseous exchange in persons with bronchial asthma was studied in 7 out-patients before, during and up to 90 minutes after intravenous injection of 0,48 g of Euphillin, and the data were related to the respective serum levels of the drug. The patients suffered from long-standing bronchial asthma, generally associated with moderate airways obstruction. The bronchodilating effect of Euphyllin could be substantiated for the whole time of the trial solely in respect of the changes in oscillatory impedence; the other parameters showed only temporary changes which had disappeard by the end of the trial although the serum levels of aminophylline were in the therapeutic range (mean +/- SD: 12,5 +/- 3,0 microgram/ml). The data indicate that in some patients with bronchial asthma the effect of Euphyllin on lung function is unpredictable. The suggestion is made to measure the responsiveness of the patient to aminophylline by means of simple lung function tests in order to decide whether or not other bronchodilatory substances should be aded to the therapy.
D000328:Adult; D001249:Asthma / Q000188:drug therapy*; D004338:Drug Combinations; D005029:Ethylenediamines / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D010101:Oxygen Consumption / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D013806:Theophylline / Q000008:administration & dosage / Q000627:therapeutic use*
D004338:Drug Combinations; D005029:Ethylenediamines; D013806:Theophylline
Die Wirkung von intravenösem Theophyllin-Athylendiamin auf  die Atemmechanik und den Gasaustausch bei Patienten mit Asthma bronchiale.