[Effect of acrylonitrile on gamma-aminobutyric acid levels, glutamate decarboxylase activity, and lipid peroxidation in rat brain].
Acrylonitrile after intraperitoneal administration into rats decreased the content of gamma-aminobutyric (GABA) and inhibited the glutamate decarboxylase activity in brain tissue. Incubation of brain supernatant with acrylonitrile led to stimulation of lipid peroxidation and to a decrease in content of thiols, alpha-Tocopherol prevented the prooxidant effect of acrylonitrile in vitro as well as its effect on glutamate decarboxylase activity and on GABA content in vivo. The neurotoxic effect of acrylonitrile might be related to stimulation of lipid peroxidation.
D000181:Acrylonitrile / Q000506:poisoning*; D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D001923:Brain Chemistry; D002262:Carboxy-Lyases / Q000378:metabolism*; D005260:Female; D005968:Glutamate Decarboxylase / Q000378:metabolism*; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008297:Male; D009570:Nitriles / Q000506:poisoning*; D051381:Rats; D013438:Sulfhydryl Compounds / Q000032:analysis; D005680:gamma-Aminobutyric Acid / Q000032:analysis*
D008054:Lipid Peroxides; D009570:Nitriles; D013438:Sulfhydryl Compounds; D005680:gamma-Aminobutyric Acid; D002262:Carboxy-Lyases; D005968:Glutamate Decarboxylase; D000181:Acrylonitrile
Vliianie akrilonitrila na uroven' gamma-aminomaslianoĭ kisloty, aktivnost' glutamatcekarboksilazy i perekisnoe okislenie lipidov v golovnom mozge krys.