[Asphyxial shock and disseminated intravascular coagulation (DIC) in animal experiments. 2. Morphometric tests and blood coagulation studies (author's transl)].
First intravascular coagula were detected as early as in the pre-acidotic phase of artificially hypoxic rabbit foetuses used by the authors in experimental studies. Growing acidosis in circulating blood has been accompanied by excessive increase of fibrin precipitation in the terminal blood track. Further increase of intravascular coagulation was found to be discontinued by predominance of secondary fibrinolysis at blood pH around 6.9. Rising hydrogen ion concentration, as a reflection of a consumptional reaction, was found to be accompanied by decline in both the fibrinogen level and thrombocyte count in the foetal blood, fully in parallel with the above DIC.
D000818:Animals; D001237:Asphyxia / Q000503:physiopathology*; D001780:Blood Coagulation Tests; D004195:Disease Models, Animal; D004211:Disseminated Intravascular Coagulation / Q000503:physiopathology*; D005260:Female; D005337:Fibrin / Q000502:physiology; D006863:Hydrogen-Ion Concentration; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000503:physiopathology*; D011817:Rabbits; D012769:Shock
D005337:Fibrin
Asphyktischer Schock und disseminierte intravasale Gerinnung (DIC) im Tierversuch. 2. Mitteilung: Morphometrische und Blutgerinnungsuntersuchungen.