[Effect of lysosomal cathepsin D and acid phosphatase on collagen protein catabolism in cirrhotically altered liver after stimulating regeneration with choriogonin].
Dependence of collagen fractions content from the activities of cathepsin D and acid phosphatase as well as dynamics of their alteration under the influence of choriogonine were studied in cirrhotic liver tissue of rats. Content of the collagen proteins was decreased, with simultaneous increase in amount of their soluble fractions, after treatment of the animals by choriogonine. At the first step of the experiment the activity of the hydrolytic enzymes was decreased but it was normalized to the end of the experiment; at the same time, activity of cathepsin D remained high in the non-sedimentable fraction. Correlation between the activity of cathepsin D and content of collagen fractions was observed in the liver tissue. This enzyme appears to participate in catabolism of collagen.
D000135:Acid Phosphatase / Q000378:metabolism*; D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000150:complications; D002403:Cathepsins / Q000378:metabolism*; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D003094:Collagen / Q000378:metabolism*; D008099:Liver / Q000201:enzymology / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000139:chemically induced / Q000188:drug therapy* / Q000378:metabolism; D008115:Liver Regeneration; D008297:Male; D051381:Rats
D006063:Chorionic Gonadotropin; D003094:Collagen; D000135:Acid Phosphatase; D002403:Cathepsins
Vliianie katepsina D i kisloĭ fosfatazy lizosom na katabolizm kollagenovykh belkov v tsirotticheski izmennoĭ pecheni v usloviiakh stimuliatsii regeneratsii khoriogoninom.