[Changes in oxidative phosphorylation in rat liver mitochondria during the development of cholestasis].
Kinetic patterns of oxydative phosphorylation were studied in rat liver mitochondria in dynamics of cholestasis and after addition of bile acids to mitochondria in vitro. Within the 1 and 3 days of cholestasis mitochondrial synthesis of ATP was decreased due to inhibition of ATP and ADP transport by the bile acids. At the period within 3 and 15 days uncoupling of the oxidative phosphorylation occurred; the phenomenon observed might be a result of impairment in the structure of inner mitochondrial membrane.
D000227:Adenine Nucleotides / Q000378:metabolism; D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology; D002331:Carnitine / Q000494:pharmacology; D001651:Cholestasis, Extrahepatic / Q000378:metabolism*; D006801:Humans; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism*; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism; D010085:Oxidative Phosphorylation; D051381:Rats; D012710:Serum Albumin, Bovine / Q000494:pharmacology; D013386:Succinates / Q000378:metabolism
D000227:Adenine Nucleotides; D001647:Bile Acids and Salts; D013386:Succinates; D012710:Serum Albumin, Bovine; D000226:Mitochondrial ADP, ATP Translocases; D002331:Carnitine
Izmeneniia okislitel'nogo fosforilirovaniia v mitokhondriiakh pecheni krys pri razvitii kholestaza.