Isolation and characterization of a mutant of Pseudomonas aureofaciens ATCC 15926 with an increased capacity for synthesis of pyrrolnitrin.
A mutant having a 30-fold increased ability to synthesize pyrrolnitrin was isolated from Pseudomonas aureofaciens ATCC 15926 after mutagenesis with N-methyl-N'-nitro-N-nitrosoguanidine. The mutant strain also differed from the parent strain in pigmentation and in its inability to catabolize anthranilic acid and the benzene moiety of tryptophan and kynurenine.
D000935:Antifungal Agents / Q000096:biosynthesis*; D007737:Kynurenine / Q000378:metabolism; D008769:Methylnitronitrosoguanidine / Q000494:pharmacology; D009154:Mutation; D011549:Pseudomonas / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D011764:Pyrrolnitrin / Q000096:biosynthesis*; D014364:Tryptophan / Q000378:metabolism; D062367:ortho-Aminobenzoates / Q000378:metabolism
D000935:Antifungal Agents; D062367:ortho-Aminobenzoates; D008769:Methylnitronitrosoguanidine; D007737:Kynurenine; D014364:Tryptophan; D011764:Pyrrolnitrin