The effect of displacement from protein binding on serum and tissue fluid levels of cephazolin.
Displacement of cephazolin, a highly protein-bound beta-lactam antibiotic, by sulpha-phenazole was studied in vitro and in vivo. In vitro, the sulphonamide was effective in displacing the antibiotic from its binding sites at the concentration 100--1000 mumol 1(-1). In vivo, both the serum and the tissue fluid concentration of free cephazolin increased significantly in rats concomitantly treated with sulphaphenazole.
D000818:Animals; D001665:Binding Sites; D001798:Blood Proteins / Q000378:metabolism; D001826:Body Fluids / Q000378:metabolism; D002437:Cefazolin / Q000097:blood / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D011485:Protein Binding; D051381:Rats; D013426:Sulfaphenazole / Q000378:metabolism
D001798:Blood Proteins; D013426:Sulfaphenazole; D002437:Cefazolin