title: The effect of neostigmine on suxamethonium induced neuromuscular block in the dog.
abstract: The effects of neostigmine on suxamethonium induced neuromuscular block were investigated in the intact, anaesthetised dog using the train-of-four twitch to record neuromuscular activity. Marked antagonism of the block was observed when the train-of-four ratio was 0.38 and less. To avoid potentiating the block, the use of neostigmine is not recommended without first determining the state of neuromuscular activity with a peripheral nerve stimulator using train-of-four stimulation.
mesh_terms: D000818:Animals; D004285:Dogs / Q000502:physiology*; D009388:Neostigmine / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D013390:Succinylcholine / Q000494:pharmacology*
chemical_list: D009388:Neostigmine; D013390:Succinylcholine