title: Microbial conversion of epsilon-pyrromycinone and epsilon-isorhodomycinone to 1-hydroxy-13-dihydrodaunomcyin and N-formyl-1-hydroxy-13-dihydrodaunomycin and their bioactivities.
abstract: New anthracycline antibiotics, 1-hydroxy-13-dihydrodaunomycin and N-formyl-1-hydroxy-13-dihydrodaunomycin were biosynthesized by a blocked mutant of Streptomyces coeruleorubidus ME130-A4 from epsilon-pyrromycinone or epsilon-isorhodomycinone.
mesh_terms: D000818:Animals; D018943:Anthracyclines; D000900:Anti-Bacterial Agents / Q000378:metabolism* / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic; D001711:Biotransformation; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003630:Daunorubicin / Q000031:analogs & derivatives*; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D009153:Mutagens; D009154:Mutation; D009279:Naphthacenes / Q000378:metabolism / Q000494:pharmacology; D013302:Streptomyces / Q000378:metabolism
chemical_list: D018943:Anthracyclines; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D009153:Mutagens; D009279:Naphthacenes; C027840:epsilon-isorhodomycinone; C009142:epsilon-pyrromycinone; C027833:1-hydroxy-13-dihydrodaunomycin; C027834:N-formyl-1-hydroxy-13-dihydrodaunomycin; D003630:Daunorubicin