A pyrogen derived from human white cells which is active in mice.
An endogenous pyrogen smaller in molecular size than that previously obtained from human white cells has been found in supernatants of these cells after uptake of zymosan and incubation for 18 h. The new pyrogen after separation from other pyrogens which are produced at the same time has been found to produce fever in mice but not in rabbits. Because it is not formed if cycloheximide is present and is inactivated by leucine aminopeptidase, it is believed to be a peptide.
D000818:Animals; D002850:Chromatography, Gel; D006801:Humans; D007375:Interleukin-1; D007525:Isoelectric Focusing; D007962:Leukocytes / Q000032:analysis*; D051379:Mice; D011506:Proteins / Q000302:isolation & purification / Q000633:toxicity*; D011749:Pyrogens / Q000302:isolation & purification / Q000633:toxicity*; D011817:Rabbits; D015054:Zymosan
D007375:Interleukin-1; D011506:Proteins; D011749:Pyrogens; C008270:leukocyte endogenous mediator; D015054:Zymosan