Computer evaluation of cytostatic properties of compounds. I. In vitro studies on inhibitory and stimulative activities by CY-VTP/1 program for ODRA-1204 computer.
For the first step of in vitro investigation on the basis of NCI, NIH examination procedure of cytostatics, an evaluation program (CY-VTP/1 in ALGOL-1204) of stimulative and inhibitory activity was prepared for the Polish ODRA-1204 computer. The program allows: a) variety of investigations in connection with possibilities of alternative usage of examination variants; b) comparison with NCI, NIH results, with an optimum for verification and unification with every program; c) to show the inhibitory and stimulative activity of compounds; d) to obtain precise data from a great series of compounds; e) to determine the range of concentration for detailed examinations using CY-VTP/2 program (second step).
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002273:Carcinogens; D002455:Cell Division / Q000187:drug effects; D003201:Computers; D003864:Depression, Chemical; D004353:Drug Evaluation, Preclinical / Q000379:methods; D006801:Humans; D066298:In Vitro Techniques; D009369:Neoplasms / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D011044:Poland; D013268:Stimulation, Chemical
D000970:Antineoplastic Agents; D002273:Carcinogens