High pressure, diazepam and pH influences on ketamine anaesthesia in the rat.
Ketamine infusion anaesthesia was studied in rats breathing oxygen/helium under hyperbaric conditions from 1 to 90 ATA. No pressure reversal of the analgesic effect was found. Premedication with diazepam failed to improve the analgesic action of ketamine, but influenced the respiratory pattern. Blood-gas analyses showed a marked relationship between arterial pH and the ketamine dose requirement for stable anaesthesia.
D000758:Anesthesia; D000818:Animals; D003975:Diazepam / Q000494:pharmacology*; D006863:Hydrogen-Ion Concentration; D007649:Ketamine; D008297:Male; D011229:Preanesthetic Medication; D011312:Pressure; D051381:Rats; D013874:Thiopental
D007649:Ketamine; D013874:Thiopental; D003975:Diazepam