[Changes in lactate dehydrogenase activity and lactic and pyruvic acid concentration in the blood and tissues of animals following intravenous administration of perfluorotributylamine emulsions].
Activity of lactate dehydrogenase (LDH) and concentration of lactate and pyruvate were studied in rat and cat tissues after infusion of perfluorotributylamine emulsion. Administration of the emulsion caused an increase in content of lactate and pyruvate as well as LDH activation in the animal blood and tissues. Tissue hypoxia, responsible for stimulation of glycolytic pathway of carbohydrate metabolism, was apparently developed due to transfer of inadequate amount of oxygen by perfluorotributylamine.
D000818:Animals; D001802:Blood Substitutes / Q000494:pharmacology*; D002082:Butylamines / Q000494:pharmacology*; D002415:Cats; D005466:Fluorocarbons / Q000494:pharmacology*; D007668:Kidney / Q000378:metabolism; D007770:L-Lactate Dehydrogenase / Q000378:metabolism*; D007773:Lactates / Q000032:analysis*; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D009206:Myocardium / Q000032:analysis; D011773:Pyruvates / Q000032:analysis*; D051381:Rats; D013045:Species Specificity; D013154:Spleen / Q000378:metabolism
D001802:Blood Substitutes; D002082:Butylamines; D005466:Fluorocarbons; D007773:Lactates; D011773:Pyruvates; C008807:perfluorotributylamine; D007770:L-Lactate Dehydrogenase
Izmenenie aktivnosti laktatdegidrogenazy i soderzhaniia molochnoĭ i pirovinogradnoĭ kislot v krovi i tkaniakh zhivotnykh posle vnutrivennogo vvedeniia émul'sii perftortributilamina.