Inhibition of bone marrow cell proliferation and DNA replication induced by chloramphenicol.
The effect of CAP on proliferations of bone marow cells from unirradiated and irradiated (4.78 Gy) C57BL/10 mice was investigated by 3H-dTh incorporation into DNA of individual cells using autoradiography. CAP was administered from day 7 to day 10 after irradiation. CAP decreases the rate of entry of cells into S phase and the rate of 3H-dTh incorporation into DNA during replication. Cells of the erythropoietic series are mainly involved in this decrease. CAP has roughly the same inhibitory effect on unirradiated and irradiated cell populations.
D000818:Animals; D001345:Autoradiography; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects* / Q000528:radiation effects; D002701:Chloramphenicol / Q000494:pharmacology*; D004261:DNA Replication / Q000187:drug effects*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL
D002701:Chloramphenicol