Multiple myeloma and gastric carcinoma. Possible late effects of limited abdominal X-irradiation.
A man, aged 34, was treated in 1954 for duodenal ulcer by antroduodenectomy followed by X-irradiation to the stomach in a dose of 2,000 rads. Over two decades, he developed several conditions attributable to the previous irradiation, including the physical appearances of premature ageing, shrinkage of the left kidney due to irradiation nephritis, immune deficiency, multiple myeloma of IgA type, and lastly, carcinoma of the stomach. The kidneys, especially the left, the bone marrow and stomach would have been in the field of X-irradiation. These effects of local X-irradiation are discussed in relation to the known effects of total body irradiation in causing decreased longevity in animals and inducing cancer in man.
D000375:Aging; D004381:Duodenal Ulcer / Q000532:radiotherapy; D006801:Humans; D007668:Kidney / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced; D009393:Nephritis / Q000209:etiology; D011879:Radiotherapy Dosage; D013274:Stomach Neoplasms / Q000209:etiology*