Familial association of giant cell arteritis. A case report and brief review.
The initial report of a father-daughter pair with giant cell arteritis (GCA) is made. To our knowledge, it represents only the 12th known familial aggregation of polymyalgia rheumatica (PMR) and/or GCA. This provides evidence for direct transmission of GCA during the two generations and helps to establish a genetic mode of inheritance for this disease. Clinically, the familial and nonfamilial forms of PMR and/or GCA are indistinguishable.
D000368:Aged; D005260:Female; D013700:Giant Cell Arteritis / Q000235:genetics*; D006801:Humans; D008297:Male; D011111:Polymyalgia Rheumatica / Q000235:genetics; D014786:Vision Disorders / Q000209:etiology