Synthesis and anti-inflammatory activity of 4H-1,4-benzothiazines.
A new series of 4H-1,4-benzothiazine derivatives have been synthesized. These products were obtained by treatment with SO2Cl2 in dry ether at room temperature of 1,3-benzothiazolines N-acetylated. The 1,3-benzothiazolines were prepared by condensation in benzene of 2-aminothiophenol with several ketones, in the presence of p-toluenesulphonic acid as catalyst. Preliminary pharmacological studies on the anti-inflammatory activity of these compounds are reported.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis* / Q000627:therapeutic use; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002855:Chromatography, Thin Layer; D004487:Edema / Q000188:drug therapy; D008297:Male; D051381:Rats; D013843:Thiazines / Q000138:chemical synthesis* / Q000627:therapeutic use
D000893:Anti-Inflammatory Agents; D013843:Thiazines