Carcinogenesis by derivatives of 1-nitroso-3,5-dimethylpiperazine in rats.
Four mononitrosopiperazines were administered to groups of 20 female Fischer 344 rats to compare their effectiveness as carcinogens. The four, 1-nitroso-3,5-dimethylpiperazine, its 4-acetyl derivative, its 4-benzoyl derivative, and 1-nitroso-3,4,5-trimethylpiperazine, were given as 0.7 mM solutions in drinking water, 100 ml to each rat per week. The length of treatment varied from 26 weeks for nitrosotrimethylpiperazine to 50 weeks for 1-nitroso-3,5-dimethyl-4-benzoylpiperazine. Dimethyl- and trimethylnitrosopiperazine gave rise to virtually 100% incidence of undifferentiated lymphomas of the thymus and leukemias within 30 weeks (in contrast to the non-C-methylated analogs which are noncarcinogenic or only weakly so). Acetyldimethylnitrosopiperazine was also a potent carcinogen, all of the rats treated with it dying within 30 weeks with tumors of the esophagus. In contrast, benzoyldimethylnitrosopiperazine was weakly carcinogenic, inducing only a small number of tumors of the forestomach and reducing the normal life span of the rats very little.
D000818:Animals; D002277:Carcinoma / Q000139:chemically induced; D005260:Female; D006258:Head and Neck Neoplasms / Q000139:chemically induced; D007942:Leukemia, Experimental / Q000139:chemically induced; D009297:Nasal Mucosa; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D009602:Nitrosamines; D010879:Piperazines; D051381:Rats; D013945:Thymoma / Q000139:chemically induced
D009602:Nitrosamines; D010879:Piperazines; C014710:N-nitroso-N'-methylpiperazine; C028489:1-nitroso-4-benzoyl-3,5-dimethylpiperazine; C028487:1-nitroso-3,5-dimethylpiperazine; C028488:1-nitroso-4-acetyl-3,5-dimethylpiperazine; C028486:1-nitroso-3,4,5-trimethylpiperazine; C014711:1-nitrosopiperazine