[Toxicity and radioprotective properties of heterocyclic compounds containing a hydrazine fragment].
Toxicity and radioprotective properties of 17 chemical compounds containing a hydrazine fragment have been studied in experiments on mice. It has been established that the radioprotective action of the test compounds does not depend substantially on whether the hydrazine fragment enters the heterocyclic moiety fully, partly or as an exocyclic substituent in the ring.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005260:Female; D006168:Guinea Pigs; D006571:Heterocyclic Compounds / Q000627:therapeutic use / Q000633:toxicity*; D006834:Hydrazines / Q000627:therapeutic use / Q000633:toxicity*; D007928:Lethal Dose 50; D011833:Radiation Injuries, Experimental / Q000517:prevention & control; D011837:Radiation-Protective Agents; D013329:Structure-Activity Relationship
D006571:Heterocyclic Compounds; D006834:Hydrazines; D011837:Radiation-Protective Agents
Toksichnost' i radiozashchitnye svoĭstva geterotsiklicheskikh soedineniĭ, soderzhashchikh gidrazinovyĭ fragment.