[Evaluation of chlorobenzene exposure on the basis of determination of 4-chlorocatechol in urine].
Both animal (rats) experiments and examinations of dyestuff industry workers exposed to chlorobenzene allowed to identify 4-chlorocatechol as one of the major chlorobenzene metabolites. 4-chlorocatecholuria was found to be monophasic with 24 h half-time, which indicates that concentrations are likely to increase in the body with everyday exposure. The 4-chlorocatechol test based on thin-layer chromatography and absorptiometry appeared to be fully useful for exposure evaluation and chlorobenzene poisonings diagnostics.
D000328:Adult; D000393:Air Pollutants / Q000633:toxicity*; D000395:Air Pollutants, Occupational / Q000633:toxicity*; D000818:Animals; D002396:Catechols / Q000652:urine*; D002617:Chemical Industry; D002722:Chlorobenzenes / Q000378:metabolism / Q000633:toxicity*; D004781:Environmental Exposure; D006207:Half-Life; D006801:Humans; D008297:Male; D008452:Maximum Allowable Concentration; D008875:Middle Aged; D051381:Rats
D000393:Air Pollutants; D000395:Air Pollutants, Occupational; D002396:Catechols; D002722:Chlorobenzenes
Ocena narazenia na chlorobenzen na podstawie oznaczania 4-chlorokatecholu w moczu.