Massive intravenous bolus bretylium tosylate.
A 30 mg/kg (2-gm) intravenous bolus of bretylium tosylate was administered to a patient with recurrent ventricular tachycardia and fibrillation. After successful defibrillation the patient exhibited marked hypertension followed by protracted refractory hypotension. There was no further ventricular ectopy in spite of a very low cardiac index. A bretylium level of 8,800 ng/ml is the highest reported in man from a single bolus injection. This case demonstrates the exaggerated hemodynamic response to massive intravenous bolus bretylium tosylate.
D001949:Bretylium Compounds / Q000008:administration & dosage*; D001950:Bretylium Tosylate / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D007022:Hypotension / Q000139:chemically induced; D007275:Injections, Intravenous; D008297:Male; D008508:Medication Errors; D008875:Middle Aged; D014693:Ventricular Fibrillation / Q000188:drug therapy
D001949:Bretylium Compounds; D001950:Bretylium Tosylate