title: 4-Demethoxy-4-hydroxydaunorubicin 6-methyl ether and 11-methyl ether, two active isomers of daunorubicin.
abstract: The preparation of two isomers of daunorubicin, one having a completely chelated dihydroxyanthraquinone chromophor (III) and one have having such a chromophor in a emichelated form (IV), is reported. The former is as active as daunorubicin, the latter shows a considerable activity, however at much higher doses.
mesh_terms: D000818:Animals; D000903:Antibiotics, Antineoplastic; D055598:Chemical Phenomena; D002621:Chemistry; D003630:Daunorubicin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D007536:Isomerism; D007942:Leukemia, Experimental / Q000188:drug therapy; D051379:Mice
chemical_list: D000903:Antibiotics, Antineoplastic; D003630:Daunorubicin