title: Studies on hemopoietic dysplasia (the preleukemic syndrome). Clinical course and prognostic factors in 42 patients with dysplastic bone marrow.
abstract: The clinical course of 42 patients with hemopoietic dysplasia diagnosed during 1974-77 has been studied. The clinical, laboratory and morphological findings at presentation were investigated for prognostic significance. At the time of completion of the study (Aug. 1979), 38% had developed acute leukemia (median survival after diagnosis 5 months) and 45% had died of complications (bleeding and infections) due to severe cytopenia (median survival 6 months). An overall malignant course was observed in patients with low platelet count (less than 80 X 10(9)/l), bleedings and severe myeloid maturation defect in the bone marrow (greater than or equal to 30% myeloblasts and promyelocytes). Increased serum vitamin B12 and presence of myeloblasts, promyelocytes and abnormal "monocytoid' cells in the peripheral blood indicated a leukemic termination.
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D010976:Platelet Count; D011289:Preleukemia / Q000097:blood / Q000150:complications / Q000473:pathology*; D011379:Prognosis; D013921:Thrombocytopenia / Q000209:etiology; D014805:Vitamin B 12 / Q000097:blood
chemical_list: D014805:Vitamin B 12