title: Calcium emboli to the retinal artery in calcific aortic stenosis.
abstract: It is generally appreciated in the cardiovascular literature that calcium emboli to a central retinal artery or its branches may be the presenting feature of otherwise uncomplicated calcific aortic stenosis. The ophthalmologic literature provides good evidence for this point. Over a 7-month period, four such cases have come to our attention. Other potential sources of emboli were excluded by standard noninvasive and invasive diagnostic techniques, and two patients underwent successful aortic valve replacement. Previous studies of calcific aortic stenosis have demonstrated postmortem histologic evidence of calcium emboli to various organs, for example, heart, kidney, or brain. Since these emboli are small, their occurrence is clinically silent. The retinal circulation is unique in that its occlusion by a calcium microembolus results in loss of vision, and this symptom may be a clue to the presence of calcific aortic stenosis.
mesh_terms: D000328:Adult; D001024:Aortic Valve Stenosis / Q000150:complications*; D001766:Blindness / Q000209:etiology; D002114:Calcinosis / Q000150:complications*; D002118:Calcium; D002561:Cerebrovascular Disorders / Q000209:etiology; D004617:Embolism / Q000150:complications* / Q000175:diagnosis / Q000628:therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012161:Retinal Artery / Q000503:physiopathology*; D012164:Retinal Diseases / Q000209:etiology
chemical_list: D002118:Calcium