title: Antiinflammatory activity of the new aminomethyl derivatives of 1-cyclohexyl-5-alkyl and 1-cyclohexyl-5,5-dialkylbarbituric acids.
abstract: Several new aminomethyl derivatives of barbituric acid were evaluated pharmacologically. 1-Cyclohexyl-5-piperidylmethyl-5-allylbarbituric acid and 1-cyclohexyl-3-morpholinomethyl-5,5-diallylbarbituric acid displayed antinflammatory activity in the carrageenin-edema and xylene-tests but did not produce analgesia. It has been also found that introduction of aminomethyl groups into the antiinflammatory barbituric derivatives brings about elevation of the resorption of the tested compounds.
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents; D001463:Barbiturates / Q000138:chemical synthesis / Q000627:therapeutic use*; D004487:Edema / Q000188:drug therapy; D010146:Pain / Q000188:drug therapy; D010653:Phenylbutazone / Q000627:therapeutic use; D051381:Rats
chemical_list: D000893:Anti-Inflammatory Agents; D001463:Barbiturates; D010653:Phenylbutazone