Antihypertensive (2-aminoethyl)thiourea derivatives. 1.
Structure-activity studies were carried out on a series of antihypertensive 1-(2-aminoethyl)-3-(substituted phenyl)thioureas. From this class of compounds, the 2,6-dichlorophenyl analogue 2 was found to have potent oral antihypertensive activity in two hypertensive rat models and the renal hypertensive dog. In addition to its effect on blood pressure, 2 displayed sedative effects which had a marked species specificity.
D000818:Animals; D000959:Antihypertensive Agents / Q000138:chemical synthesis*; D001362:Avoidance Learning / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D055598:Chemical Phenomena; D002621:Chemistry; D003000:Clonidine / Q000494:pharmacology; D004285:Dogs; D008297:Male; D010670:Phenylthiourea / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D051381:Rats; D012453:Saimiri; D013045:Species Specificity
D000959:Antihypertensive Agents; D010670:Phenylthiourea; D003000:Clonidine