Distribution of complement C'2 and C'6 types in Australian cases of diabetes mellitus.
A series of patients with juvenile onset diabetes (IDDM) and mature onset diabetes (NIDDM) have been typed for genetic variants of two sets of complement factors. For the HLA-linked C'2 system, there was found a significant increase of the C'2 2-1 type in IDDM compared with NIDDM patients or healthy controls. No such increase in any phenotype was observed for the non-HLA-linked C'6 system. These observations emphasize again the genetic distinction between IDDM and NIDDM, and the role of chromosome 6 in controlling susceptibility to the insulin-dependent form of the disease.
D000483:Alleles; D001315:Australia; D002648:Child; D003175:Complement C2 / Q000235:genetics*; D003183:Complement C6 / Q000235:genetics*; D003920:Diabetes Mellitus / Q000235:genetics*; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008875:Middle Aged; D010641:Phenotype
D003175:Complement C2; D003183:Complement C6; D006680:HLA Antigens