title: [Association of Pick's disease and amyotrophic lateral sclerosis. Pathological study of one case and review of the literature (author's transl)].
abstract: An anatomoclinical case of Pick's Dementia secondarily complicated with Amyotrophic Lateral Sclerosis (A.L.S.) has been compared with twelve similar cases from the litterature. These comparisons drive to three hypotheses:--coincidence of two distinct diseases;--extension to motor cortex of the Pick's atrophy;--atypical onset of ALS outside of motor cortex, secondarily reaching the motor area. Against the last hypothesis, one could argue that, in "Pick's disease + ALS", there is no superficial spongiosis such as seen generally in ALS + Dementia in frontal or temporal cortex, or in ALS simplex in motor cortex. Also, there are marked focal lesions, i.e. in uncus hippocampi, similar to that of Pick's disease. However, if the second hypothesis seem to be the best one, there are actually no definite evidence for it.
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000150:complications* / Q000473:pathology; D003704:Dementia / Q000150:complications* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged
vernacular_title: L'association maladie de Pick et sclérose latérale amyotrophique. Etude d'un cas anatomo-clinique et revue de la littérature.