[Adriamycin-cardiomyopathy induced by an increment of (Ca2+) (author's transl)].
As compared to the metabolic inhibitor 2,4-Dinitrophenol, the cytostatic drug Adriamycin influences the isolated embryo ventricular cells of the chicken, thus causing a decrease in the contraction amplitude, an increase in the heart-rate, and the occurrence of "after-contractions". With radioactive measurements it could be demonstrated, that the reason therefore is an increment of Ca2+i. This may be explained by a decreased Ca-uptake by the sarcoplasmic reticulum and the mitochondria. This increment of Ca2+i brought about a change in the action potential and the refractory-period, as well as the occurrence of "'after-contractions" by control of the potassium flux.
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D009202:Cardiomyopathies / Q000139:chemically induced*; D002642:Chick Embryo; D004317:Doxorubicin / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D008928:Mitochondria / Q000187:drug effects; D009200:Myocardial Contraction / Q000187:drug effects; D012519:Sarcoplasmic Reticulum / Q000187:drug effects
D004317:Doxorubicin; D002118:Calcium
Erhöhung des frei-ionisierten zytoplasmatischen Calciums als Ursache der Adriamycin-Kardiomyopathie.