[Kinetics of anticoagulation in hemodialysis. Sequential study of single, intermittent and continuous heparinization].
A sequential real-time study was run to monitor plasma heparin values following three standard dose protocols during 4-hr dialysis, using an enzymatic method. One group of patients was given a single dose of 7000 IU at the commencement of dialysis, a second group 5000 IU at the start and 2500 IU at the end of the third hour, and a third group 2500 IU at the start and 1500 UI/hr for four hours. Plasma levels were checked every hour and ranged from 0.702 IU/ml (+/- 0.069) (start) to 0.290 IU/ml (+/- 0.079) (end) in the first group, 0.552 (+/- 0.116) to 0.312 (+/- 0.09) in the second, and 0.456 (+/- 0.113) to 0.314 (+/- 0.063) in the third. Correlation of heparin levels with coagulation time led to the establishment of an optimal range of 0.2 to 0.6 IU/ml.
D001780:Blood Coagulation Tests; D006470:Hemorrhage / Q000517:prevention & control; D006493:Heparin / Q000008:administration & dosage / Q000097:blood / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy*; D008991:Monitoring, Physiologic; D006435:Renal Dialysis; D013927:Thrombosis / Q000517:prevention & control; D014511:Uremia / Q000628:therapy*
D006493:Heparin
Cinetica dell'anticoagulazione in emodialisi. Studio sequenziale sull'eparinizzazione unica, intermittente e continua.