The source of gallium-67 in gastrointestinal contents: concise communication.
The sources of Ga-67 in gastrointestinal (GI) contents, and factors affecting its secretion were studied in rats. To prevent loss of fecal Ga-67, the anus was sutured before intravenous injection of Ga-67 citrate. Secretion of Ga-67 into the contents of the GI tract was rapid, 3, 6, and 9% of the injected dose were secreted at 1, 6, and 24 hr after injection, respectively. In contrast, Ga-67 concentration in the GI tissues remained relatively constant throughout this period. Analysis of Ga-67 contents of various parts of the GI trace revealed that small intestine is its major source, contributing 60% while the bile contributes 20%, large intestine 10%, GI contents. In contrast, the serum unbound iron-binding capacity (UIBC) played an important role in the Gl secretion of Ga-67 reducing the serum UIBC reduced the Ga-67 secretion into GI contents.
D000818:Animals; D001646:Bile / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism*; D004435:Eating; D004947:Esophagus / Q000378:metabolism; D005710:Gallium Radioisotopes / Q000008:administration & dosage / Q000097:blood; D005753:Gastric Mucosa / Q000378:metabolism; D007275:Injections, Intravenous; D007420:Intestine, Large / Q000378:metabolism; D007421:Intestine, Small / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D013997:Time Factors
D005710:Gallium Radioisotopes