title: Absence of fractionation, protraction, radiation quality, and radical scavenger effects on radiation-induced interphase death of human G0 lymphocytes in vitro.
abstract: In vitro interphase death of human peripheral blood lymphocytes, measured by shortening of the mean lifetime of small G0 lymphocytes, was studied with 150 kV and 10 kV X-rays. No effect of radiation quality, of fractionation and of protraction was observed. The possibility of protection by L-cysteine and DMSO was tested in cells irradiated with 150 kV X-rays, but no protection effect with respect to cell survival could be demonstrated. Non-DNA radiation-sensitive site(s), possibly the cell membrane, appear to be responsible for interphase death.
mesh_terms: D002462:Cell Membrane / Q000528:radiation effects; D002470:Cell Survival; D003545:Cysteine / Q000494:pharmacology; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D006801:Humans; D007399:Interphase; D008214:Lymphocytes / Q000528:radiation effects*; D011829:Radiation Dosage
chemical_list: D003545:Cysteine; D004121:Dimethyl Sulfoxide