[Role of the microsomal enzymatic activity changes induced by peloid applications in the biotransformation and effect of pharmacological preparations].
Body exposure to the physical therapeutic factor (skin applications of heated peloid) leads to the acceleration of hydroxylase reactions proceeding on cytochrome P450. This circumstance determines the speeding up of the biotransformation of a number of pharmacological agents (strychnine, aniline, amidopyrine, etc.), and changes in the action of some drugs (phenobarbital, amidopyrine,, ethazole) affecting the drug-metabolizing microsomal system.
D000814:Aniline Compounds / Q000378:metabolism / Q000494:pharmacology; D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D006900:Hydroxylation; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology*; D009094:Mud Therapy; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D013331:Strychnine / Q000378:metabolism / Q000494:pharmacology
D000814:Aniline Compounds; D013331:Strychnine
Rol' izmeneniĭ aktivnosti fermentov mikrosom, vyzvannykh applikatsiiami peloida, v biotransformatsii i éffekte nekotorykh preparatov.