The urinary excretion of alkaline phosphatase after the repeated parenteral administration of cadmium to rats given a high dietary supplement of zinc.
Repeated parenteral administration of cadmium (Cd) (1.5 mg Cd2+/kg, daily for 28 days) produced an initial transitory (< 4 days) increase in the urinary excretion of alkaline phosphatase within 48 h: a second and persistent phase of enzymuria developed around day 15. Pretreatment and simultaneous administration of zinc (Zn) as a dietary supplement (2000 ppm Zn2+) abolished the initial phase of enzymuria but had no effect upon the second phase.
D000469:Alkaline Phosphatase / Q000652:urine*; D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D004032:Diet; D007279:Injections, Subcutaneous; D008297:Male; D051381:Rats; D015032:Zinc / Q000494:pharmacology*
D002104:Cadmium; D000469:Alkaline Phosphatase; D015032:Zinc