Chemotherapy of feline Gnathostoma spinigerum migrating stage with multiple subcutaneous doses of ancylol.
Twelve doses of Ancylol Disophenol at 0.05 ml per pound body weight administered subcutaneously was shown to be an effective chemotherapeutic agent against migrating stage of G. spinigerum in cats. A further investigation is required to determine whether this regimen is the minimum effective therapeutic dosage. None of eight cats treated with 12 doses of 0.02 to 0.05 ml per pound body weight showed signs or symptoms of toxicity due to the treatment and there were not gross pathological changes of the organs observed on necropsy of the animals.
D000818:Animals; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D004305:Dose-Response Relationship, Drug; D006039:Gnathostoma; D007279:Injections, Subcutaneous; D009349:Nematode Infections / Q000188:drug therapy / Q000662:veterinary*; D009596:Nitrophenols / Q000627:therapeutic use*
D009596:Nitrophenols; C004862:disophenol