Studies on the natural history of the norepinephrine model of acute renal failure in the dog.
Studies on the natural history of the norepinephrine (NE) model of acute renal failure (ARF) in the dog. Group I (n = 6) was infused with NE into the renal artery (0.75 microgram/kg/min x 80 min) and glomerular filtration rate (GFR) determined sequentially. 21 days post-NE infusion (I) the GFR of the I kidneys (20 + or - (SE) 5ml/min) remained less (p less than 0.001) than the pre-I control value (44 plus or minus 2.9). Group II (n = 7) was treated in an identical fashion except that a contralateral nephrectomy (CN) was done on day 7 and the animals were prepared for micropuncture on day 16. In the animals with residual nephron function at CN, the GFR increased (p less than 0.02) from 26 plus or minus 6.4 ml/min on day 7 to 38 plus or minus 6.6 ml/min on day 14. Considerable interanimal heterogeneity of single nephron GFR (SNGFR) was demonstrated and morphologic studies revealed a very patchy lesion. Therefore, the model is reversible, heterogeneity of SNGFR is present, and the residual functioning nephrons have the capacity to undergo an increase in GFR after CN.
D058186:Acute Kidney Injury / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D004195:Disease Models, Animal; D004285:Dogs; D005919:Glomerular Filtration Rate; D006439:Hemodynamics; D007261:Infusions, Intra-Arterial; D007444:Inulin; D007677:Kidney Function Tests; D009392:Nephrectomy; D009638:Norepinephrine; D012077:Renal Artery
D007444:Inulin; D009638:Norepinephrine