Differentiation of rubella virus strains by neutralization kinetics.
The neutralization of rubella virus was investigated and shown to proceed by first order kinetics over the first 10 to 15 min. A comparison of the rate constant of neutralization (K) for six strains of rubella virus was carried out over this period of the reaction. Two particularly antibody-sensitive isolates were detected. It was noted that the three strains isolated from in utero infections were poorly neutralized by heterologous antisera when compared to postnatal strains.
D000328:Adult; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000276:immunology; D007223:Infant; D009500:Neutralization Tests; D011247:Pregnancy; D011817:Rabbits; D012409:Rubella / Q000382:microbiology; D012412:Rubella virus / Q000145:classification* / Q000276:immunology / Q000302:isolation & purification
D000956:Antigens, Viral; D007106:Immune Sera