Prenylamine-induced ventricular arrhythmias and syncopal attacks with Q-T prolongation. Report of a case and comment on therapeutic use of lignocaine.
A 70-year-old man, on prenylamine for exertional angina, complained of syncopal attacks which seemed to be caused by bursts of ventricular tachycardia associated with Q-T prolongation. These symptoms disappeared after treatment with lignocaine, and the Q-T interval gradually returned to normal when prenylamine was stopped. This communication emphasizes the possibility of the occurrence of Q-T prolongation with associated ventricular arrhythmias in patients treated with prenylamine and the usefulness of a cautious trial with lignocaine in ventricular arrhythmias linked to Q-T prolongation.
D000368:Aged; D004562:Electrocardiography; D006352:Heart Ventricles; D006801:Humans; D008012:Lidocaine / Q000627:therapeutic use*; D008297:Male; D011299:Prenylamine / Q000009:adverse effects*; D013575:Syncope / Q000139:chemically induced*; D013610:Tachycardia / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology
D008012:Lidocaine; D011299:Prenylamine