title: Coagulation parameters and heparin levels in open-heart surgery.
abstract: Coagulation parameters were studied during open-heart surgery. Severe reduction of the platelet count and of several other clotting factors was observed. The half-rate of heparin varied threefold in the patients. This may indicate that the dosage of protamine chloride prior to the end of the surgical procedure has to be adjusted to the individual heparin levels.
mesh_terms: D000990:Antithrombin III / Q000378:metabolism; D001777:Blood Coagulation; D006348:Cardiac Surgical Procedures; D005112:Extracorporeal Circulation; D005176:Factor XIII / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D006493:Heparin / Q000097:blood*; D006801:Humans; D010314:Partial Thromboplastin Time; D010976:Platelet Count; D013918:Thrombin Time
chemical_list: D000990:Antithrombin III; D005340:Fibrinogen; D006493:Heparin; D005176:Factor XIII