Comparison of the responsiveness to histamine and to Ascaris suum challenge in dogs.
The pulmonary and dermal sensitivity of a group of mongrel dogs to an extract of Ascaris suum protein was compared with the pulmonary and dermal sensitivity to histamine in this same group. We found a modest but significant correlation in the entire population between skin test reaction to histamine and to A. suum protein (r = 0.52, p < 0.05), but when the skin test results were compared with those of aerosol challenge, no significant correlation was found. However, when those dogs with reactions to histamine challenge that fell within a narrow range were considered as a separate group, there was a significant correlation between the reactions of aerosol challenge with A. suum and those of the skin tests with A. suum (r = 0.56, p < 0.025). These findings were consistent with the hypothesis that aerosol bronchoconstrictor responsiveness and immunologic responsiveness are separate attributes that combine to determine airway responsiveness to a specific antigen.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001200:Ascaris / Q000276:immunology*; D004285:Dogs; D005260:Female; D006632:Histamine / Q000276:immunology*; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007428:Intradermal Tests; D008168:Lung / Q000276:immunology*; D008170:Lung Compliance; D008297:Male; D012130:Respiratory Hypersensitivity / Q000276:immunology; D012867:Skin / Q000276:immunology
D000941:Antigens; D006632:Histamine