The relationship between coding sequences and function in some heme binding proteins.
It is known that globin genes contain three exons with the middle exon coding for a four-helical supersecondary structure responsible for heme binding. Since this portion of the globin peptide chain can be structurally superimposed onto the cytochrome c and cytochrome b5 chains (Argos and Rossmann 1979), it can be inferred that the cytochrome c gene will contain only one coding sequence while the cytochrome b5 gene will be composed of three exons as found in the globin gene.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D002417:Cattle; D003580:Cytochromes / Q000235:genetics; D005815:Genetic Code; D005914:Globins / Q000235:genetics*; D006420:Hemeproteins / Q000235:genetics*; D011487:Protein Conformation
D003580:Cytochromes; D006420:Hemeproteins; D005914:Globins