The antimycotic activity in vitro of five diols.
The antimycotic activity of ethane-1,2-diol, propane-1,2-diol, butane-1,3-diol, pentane-1,5-diol, and hexane-2,5-diol in vitro against Pityrosporum orbiculare, Candida albicans, Trichophyton rubrum, T. mentagrophytes var. interdigitale and Epidermophyton floccosum was studied. Ethane-1,2-diol had the lowest activity (MIC of 40-100 g 1(-1)), and hexane-2,5-diol the highest activity (MIC of 10-40 g 1(-1)). Among, the higher diols there can be both effective antifungal agents and substances with a lower risk of allergic and irritative skin reactions than propane-1,2-diol.
D000935:Antifungal Agents; D003883:Arthrodermataceae / Q000187:drug effects; D002072:Butylene Glycols / Q000494:pharmacology; D055598:Chemical Phenomena; D002621:Chemistry; D004353:Drug Evaluation, Preclinical; D005026:Ethylene Glycols / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects*; D006018:Glycols / Q000494:pharmacology*; D010420:Pentanes; D011409:Propylene Glycols / Q000494:pharmacology; D013045:Species Specificity
D000935:Antifungal Agents; D002072:Butylene Glycols; D005026:Ethylene Glycols; D006018:Glycols; D010420:Pentanes; D011409:Propylene Glycols; C578469:1,5-pentanediol; C007938:2,5-hexanediol