Gyrate atrophy of the choroid and retina in a cat.
An adult male, domestic short-haired cat with generalized retinal atrophy was found to have a 60-fold increase in plasma ornithine and ornithinuria. Ornithine-8-aminotransferase activity was undetectable in its tissues and in its cultured skin fibroblasts. This feline condition is thus analogous to gyrate atrophy of the choroid and retina in humans.
D000592:Amino Acid Metabolism, Inborn Errors / Q000150:complications*; D000818:Animals; D002415:Cats; D002829:Choroid; D004195:Disease Models, Animal; D008297:Male; D009952:Ornithine / Q000378:metabolism; D009953:Ornithine-Oxo-Acid Transaminase / Q000378:metabolism*; D012160:Retina / Q000473:pathology; D012162:Retinal Degeneration / Q000209:etiology / Q000378:metabolism* / Q000473:pathology; D000637:Transaminases / Q000378:metabolism*; D014603:Uveal Diseases / Q000378:metabolism
D009952:Ornithine; D000637:Transaminases; D009953:Ornithine-Oxo-Acid Transaminase