[Effect of methylation antagonists on biosynthesis of tetrapyrrole compounds by Propionibacterium shermanii].
The effect of methylation antagonists (DL-ethionine, S-adenosyl homocysteine and folic acid analogs-aminopterine, ametopterine and tomisine) on vitamin B12 and porphyrin biosynthesis of P. shermanii resting cells was studied. DL-ethionine proved the most active inhibitor. Inhibition of vitamin B12 biosynthesis induced by DL-ethionine was accompanied by increase in porphyrin formation. DL-methionine reversed the inhibitory effect of DL-ethionine on the vitamin synthesis. Other compounds tested showed a less marked effect.
D000630:Aminopterin / Q000494:pharmacology; D005001:Ethionine / Q000494:pharmacology; D005493:Folic Acid Antagonists; D008727:Methotrexate / Q000494:pharmacology; D008745:Methylation; D011166:Porphyrins / Q000096:biosynthesis*; D011424:Propionibacterium / Q000187:drug effects / Q000378:metabolism*; D012435:S-Adenosylhomocysteine / Q000494:pharmacology; D014805:Vitamin B 12 / Q000096:biosynthesis*
D005493:Folic Acid Antagonists; D011166:Porphyrins; D012435:S-Adenosylhomocysteine; D000630:Aminopterin; D014805:Vitamin B 12; D005001:Ethionine; D008727:Methotrexate
Vliianie antagonistov metilirovaniia na biosintez tetrapirrol'nykh soedineniĭ Propionibacterium shermanii.