title: Pulmonary O2 transfer during pulsatile and non-pulsatile perfusion.
abstract: The importance of the perfusion pattern for the oxygen transfer has been examined in isolated rabbit lungs perfused with plasma at constant volume inflow. The lungs were ventilated with constant tidal volume and constant end-expiratory pressure. Following a standardized rise in FIO2 the rate of rise in pulmonary venous PO2 (delta PO2/delta t) was measured during alternately pulsatile and non-pulsatile perfusion in normal lungs and in lungs made edematous by elevation of left atrial pressure. In normal lungs there was no difference in delta PO2/delta t when the two modes of perfusion were compared. In edematous lungs delta PO/delta t was statistically higher during pulsatile perfusion, indicating a beneficial effect of flow- and pressure pulsations, e.g. a better distribution of V/Q ratios throughout the lungs. In a separate series of expts. the advancement of a high O2 front through the airways was measured, and the two perfusion patterns compared. Since no difference was found, we suggest that the phenomenon of "cardiogenic gas mixing" in the airways in vivo is a result of a direct action of the heart on the lungs rather than arterial pulsations.
mesh_terms: D000818:Animals; D001692:Biological Transport; D005260:Female; D008168:Lung / Q000502:physiology* / Q000503:physiopathology; D008297:Male; D010100:Oxygen / Q000502:physiology*; D010313:Partial Pressure; D010477:Perfusion / Q000295:instrumentation / Q000379:methods; D011654:Pulmonary Edema / Q000378:metabolism / Q000503:physiopathology; D011817:Rabbits; D014692:Ventilation-Perfusion Ratio
chemical_list: D010100:Oxygen