[Lipid-reducing basic diet and serum fatty acid levels].
In 50 patients with primary hyperlipoproteinaemia during a 3 year treatment with lipid reducing metabolic basis diet in intervals of 4 months the composition of the cholesterol ester and triglyceride fatty acids of the serum was determined by means of gas chromatography. After 12--16 months in the hyperlipoproteinaemia type IIa (10 patients) in the cholesterol ester fraction, after 12 months in the hyperlipoproteinaemia type IIb (10 patients) in the cholesterol ester fraction and in the triglyceride fraction significant changes of the spectre of fatty acids developed. Palmitic acid, stearic acid, palmitoleic acid, oleic acid and eikosatrienic acid decreased, and linolic acid, linolenic acid, arachidonic acid and eikosapentaenic acid increased. In the course of the further therapy the precental proportions of the fatty acids did no more change. Triglyceride fatty acids in hyperlipoproteinaemia of type IIa and cholesterol ester fatty acids in hyperlipoproteinaemia of type IIb were not influenced. These metabolic effects of the metabolic basis diet on the spectres of fatty acids of cholesterol ester and triglyceride fractions in primary hyperlipoproteinaemia of type IIa, IIb and IV must not be seen only in their increased content of polyene fatty acids which influences the hepatogenic processes of synthesis and oxydation of fatty acids, but are traced back also to the reduced proportions of fat, mono- and disaccharide. With metabolic basis diet decreasing lipids alone we, however, did not succeed in normalising fully the composition of fatty acids, and the constellations of fatty acids of test persons with healthy metabolism were reached only approximately.
D002784:Cholesterol / Q000097:blood; D004038:Diet, Reducing; D004041:Dietary Fats / Q000008:administration & dosage*; D005227:Fatty Acids / Q000097:blood*; D006801:Humans; D006951:Hyperlipoproteinemias / Q000178:diet therapy*; D014280:Triglycerides / Q000097:blood
D004041:Dietary Fats; D005227:Fatty Acids; D014280:Triglycerides; D002784:Cholesterol
Lipidsenkende Basisdiät und Serumfettsäurenverhältnisse.