[Effect of human plasma lipoproteins on ionic conductivity of lipid bilayer membranes].
An interaction was studied between various lipoproteins (low density lipoproteins--LDL, very low density lipoproteins--LVDL, subfractions of high density lipoproteins--HDL2, HDL3) and artificial bilayer lipid membranes (BLM) produced from oxydized cholesterol. The lipoproteins increased from 100 to 1000-fold the conductivity of BLM for cations Na+, K+, Ca2+, but not for anions. Critical concentrations of the lipoproteins at which their modifying effect was manifested, correlated reciprocally with the size of the lipoprotein particles; they were arranged as follows: VLDL < LDL < HDL2 < HDL3. Decrease in the pH value lowered these critical concentrations. Addition of Ca2+ into the solution decreased the critical concentrations of VLDL and LDL from 2- to 4-fold as well as of HDL2 and HDL3--from 9- to 12-fold. The electrostatic power appears to be important in interaction between the lipoproteins and bilayer lipid membranes.
D000328:Adult; D001158:Arteries / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism*; D006801:Humans; D008051:Lipid Bilayers / Q000378:metabolism*; D008074:Lipoproteins / Q000494:pharmacology*; D008075:Lipoproteins, HDL / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000494:pharmacology; D008079:Lipoproteins, VLDL / Q000494:pharmacology; D008297:Male; D011188:Potassium / Q000378:metabolism*; D012964:Sodium / Q000378:metabolism*
D008051:Lipid Bilayers; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D002784:Cholesterol; D012964:Sodium; D011188:Potassium; D002118:Calcium
Vliianie lipoproteidov plazmy krovi cheloveka na ionnuiu provodimost' bisloĭnykh lipidnykh membran.