Possible antagonists to gastrin in parathyroid adenomas.
The high incidence of gastroduodenal ulcers in patients with hyperparathyroidism has been ascribed to gastric hyperacidity induced by hypercalcaemia. In a clinical study comprising 40 patients with solitary parathyroid adenoma, a negative correlation between serum calcium and spontaneous gastric acid secretion was found. At the same time a positive correlation was found between serum calcium and gastrin. It is concluded that gastric hyperacidity is not part of the syndrome provoked by parathyroid adenomas, and that a mechanism inhibitory to gastrin is active in these patients. It is suggested that the inhibitor could be calcitonin.
D000236:Adenoma / Q000097:blood / Q000503:physiopathology*; D000328:Adult; D000368:Aged; D002116:Calcitonin / Q000097:blood / Q000502:physiology; D002118:Calcium / Q000097:blood; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000037:antagonists & inhibitors* / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010282:Parathyroid Neoplasms / Q000097:blood / Q000503:physiopathology*
D005755:Gastrins; D010281:Parathyroid Hormone; D002116:Calcitonin; D002118:Calcium