[Mechanism of the antiherpetic action of bonafton].
The mechanism of antiherpetic action of bonaphthon was studied in experimental herpetic keratitis of rabbits infected with herpes simplex type I virus (Koptev and IC strains). Electron microscopy demonstrated that the drug inhibits herpes virus production and proliferation of virus infection because of partial impairment of the nucleocapsid "assembly" in the cell nucleus. It is assumed that the action of bonaphthon may be consequent on the inhibition of the cell synthesis of cytoplasmatic proteins incorporated into the capsids and on the derangement of the transport of virus capsid components to the cell nucleus, where these components are assembled. It has been shown that the intensity of virus reproduction in the cells decreases threefold under the effect of bonaphthon as compared to control.
D000818:Animals; D000998:Antiviral Agents; D003228:Conjunctiva / Q000187:drug effects / Q000648:ultrastructure; D003315:Cornea / Q000187:drug effects / Q000648:ultrastructure; D004353:Drug Evaluation, Preclinical; D007065:Idoxuridine / Q000627:therapeutic use*; D007635:Keratitis, Dendritic / Q000188:drug therapy* / Q000473:pathology; D008854:Microscopy, Electron; D009285:Naphthoquinones / Q000627:therapeutic use*; D011817:Rabbits; D013997:Time Factors
D000998:Antiviral Agents; D009285:Naphthoquinones; C011180:bonafton; D007065:Idoxuridine
O mekhanizme protivogerpeticheskogo deĭstviia bonaftona.