Transient concanavalin A-binding glycoproteins of the parallel fibres of the developing rat cerebellum: evidence for the destruction of their glycans.
The lifetime of the glycoprotein glycans of the rat cerebellum was followed in the 2nd and 3rd weeks of postnatal age, after injection of labelled glucosamine. It appears that a particular class of glycans binding to Concanavalin A synthesized at an early age has a short lifetime. These results indicate that the glycans of the concanavalin A-binding glycoproteins abundant on the newly formed parallel fibres are rapidly degraded between the 14th and the 18th postnatal day.
D000375:Aging; D000818:Animals; D002250:Carbon Radioisotopes; D002352:Carrier Proteins / Q000302:isolation & purification / Q000378:metabolism*; D002531:Cerebellum / Q000254:growth & development* / Q000378:metabolism; D005944:Glucosamine / Q000378:metabolism; D006023:Glycoproteins / Q000302:isolation & purification / Q000378:metabolism*; D007700:Kinetics; D011134:Polysaccharides / Q000378:metabolism*; D051381:Rats; D011952:Receptors, Concanavalin A / Q000302:isolation & purification / Q000378:metabolism*
D002250:Carbon Radioisotopes; D002352:Carrier Proteins; D006023:Glycoproteins; D011134:Polysaccharides; D011952:Receptors, Concanavalin A; C027774:concanavalin A-binding glycoproteins; D005944:Glucosamine