Increased erythrocytic spermine in Duchenne muscular dystrophy.
Erythrocytes of patients with Duchenne muscular dystrophy have been found to have elevated levels of spermine, a polyamine with a membrane-stabilizing action. Although a specific, increased spermine concentration is an additional biochemical abnormality documenting the involvement of erythrocyte membrane in Duchenne muscular dystrophy. Normal level of spermine were found in female carriers.
D002648:Child; D004912:Erythrocytes / Q000378:metabolism*; D004913:Erythrocytes, Abnormal / Q000648:ultrastructure; D005260:Female; D006461:Hemolysis; D006801:Humans; D007223:Infant; D008297:Male; D009133:Muscular Atrophy / Q000097:blood; D009135:Muscular Diseases / Q000097:blood; D009136:Muscular Dystrophies / Q000097:blood*; D009157:Myasthenia Gravis / Q000097:blood; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000097:blood*
D013096:Spermine; D013095:Spermidine