Occurrence of highly oxygen-substituted androgens in hemofiltrates of uremic patients.
The steroid fraction of hemofiltrate contains a large number of unknown steroids, which were separated by a combination of different chromatographic procedures and finally characterized by gas chromatography mass spectrometry. Besides different isomeric 3,16,17-trihydroxyandrostanes in a rather polar fraction a 3,16,17-trihydroxy-11-ketoandrostane was detected, obviously the first naturally occurring representative of 3,11,16,17-oxygen-tetrasubstituted androstanes.
D000731:Androstanes / Q000097:blood*; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods; D006801:Humans; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood*
D000731:Androstanes