title: [Absorption and excretion of cefradine in healthy volunteers (author's transl)].
abstract: From experiments in which cefradine (CED) was orally administered to healthy volunteers in doses of 1,000 mg, 500 mg and successive 250 mg after meal and 500 mg in fasting condition, the following results were obtained. 1) Absorption of CED was rapid in fasting volunteers with peak serum levels at about one hour after administration. On the other hand, the absorption was delayed in non-fasting volunteers with peak serum levels at about 2 approximately 3 hours after administration. Absorbed amounts of CED were proportional to the doses with no effect of meal. 2) Maximum urinary excretion of CED was observed in 0 approximately 2 hour-urine of fasting volunteers and 2 approximately 4 hour-urine of non-fasting volunteers. Total urinary recovery of CED was about 85% in either experiment, showing no effect of meal.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D002511:Cephalosporins / Q000097:blood*; D002515:Cephradine / Q000008:administration & dosage / Q000097:blood* / Q000652:urine; D006801:Humans; D007700:Kinetics; D008297:Male
chemical_list: D002511:Cephalosporins; D002515:Cephradine