Growth kinetics of ataxia telangiectasia lymphoblastoid cells. Evidence for a prolonged S period.
Growth rates were investigated in long-term lymphoblastoid cell lines derived from normal individuals and patients with ataxia telangiectasia (ATR). By a cell doubling method, sister chromatid exchanges, and autoradiography, the ATR cells showed a significantly longer total generation time. Autoradiography demonstrated that the difference in cell cycle was due to a specific lengthening of the S period in the ATR lymphoblasts.
D000328:Adult; D001260:Ataxia Telangiectasia / Q000473:pathology*; D002453:Cell Cycle; D002455:Cell Division; D002460:Cell Line; D002648:Child; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication; D005260:Female; D006801:Humans; D008214:Lymphocytes; D008297:Male; D008938:Mitosis; D012854:Sister Chromatid Exchange; D013997:Time Factors
D004247:DNA