Cytochalasin B does not stimulate sugar uptake into small intestine of necturus or chick.
3-O-Methylglucose accumulation by Necturus intestine was studied in the presence and absence of cytochalasin B. The effect of this agent on 3-O-methylglucose-induced changes in transepithelial potential difference was also investigated. Cytochalasin B (50 microM) blocked the rise in potential difference induced by 4 mM 3-O-methyglucose. 3-O-Methyglucose accumulation by Necturus intestine was measured; it was inhibited by cytochalasin B at concentrations of 50 and 100 microM. These results indicate that, in Necturus intestine, sodium-dependent sugar transport across the apical cell membrane is blocked by cytochalasin B.
D000818:Animals; D002645:Chickens; D003571:Cytochalasin B / Q000494:pharmacology*; D007421:Intestine, Small / Q000187:drug effects* / Q000378:metabolism; D008757:Methylglucosides / Q000378:metabolism*; D008759:Methylglycosides / Q000378:metabolism*; D009337:Necturus
D008757:Methylglucosides; D008759:Methylglycosides; D003571:Cytochalasin B