3-(p-Chlorophenyl)-4-aminobutanoic acid--resolution into enantiomers and pharmacological activity.
Racemic 3-(p-chlorophenyl)-4-aminobutanoic acid was resolved into enantiomers and their absolute configuration determined. Pharmacological activity of hydrochlorides of the racemic acid and its enantiomers has been determined. The R(+) enantiomer was found to be 4.2-9.2-fold as effective as the S(-) one and 1.4-1.9-fold as effective as the racemate.
D000818:Animals; D001418:Baclofen / Q000494:pharmacology*; D055598:Chemical Phenomena; D002621:Chemistry; D051379:Mice; D008968:Molecular Conformation; D009043:Motor Activity / Q000187:drug effects; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D001418:Baclofen