Non-steroidal anti-inflammatory agents. 4-[1-(3, 5-disubstituted-2-thio-thio-1,3,5-perhydrotriazinyl)]-2,3-dimethyl-1-phenyl-5-pyrazolones.
Several derivatives of pyrazolo-s-perhydrotriazine-2-thione were synthesized. The IR and MS of representative compounds are interpreted. The preliminary results of the anti-inflammatory test on female albino rats indicate that the compounds under test are more potent than phenylbutazone and do not produce any marked degree of ulceration.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005260:Female; D006097:Granulation Tissue / Q000187:drug effects; D010653:Phenylbutazone / Q000494:pharmacology; D011720:Pyrazoles / Q000138:chemical synthesis*; D051381:Rats
D000893:Anti-Inflammatory Agents; D011720:Pyrazoles; D010653:Phenylbutazone