Myocardial citrate metabolism in control subjects and patients with coronary artery disease.
A significant release of citrate across the myocardium was demonstrated in twenty-two patients with coronary artery disease (CAD) and in ten control subjects in fasting resting state. In both groups, increasingly negative arterio-coronary sinus (A-Cs) plasma citrate differences correlated positively to arterial plasma free fatty acid (FFA)concentrations and negatively to (A-Cs) differences of plasma glucose. This supports the hypothesis that a citrate inhibition of glycolysis at the site of phosphofructokinase is of regulatory importance for myocardial glucose metabolism, and suggests that FFA supress glucose utilization by the heart in many by this mechanism. The capacity of plasma FFA to increase myocardial citrate release was significantly higher in controls than in patients with CAD, and was found to be positively related to myocardial capacity of oxygen consumption as estimated from the product of heart rate and systolic blood pressure during an exercise tolerance test.
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D002951:Citrates / Q000097:blood / Q000378:metabolism*; D003327:Coronary Disease / Q000097:blood / Q000378:metabolism*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005260:Female; D006801:Humans; D007773:Lactates / Q000097:blood; D008297:Male; D008875:Middle Aged; D009206:Myocardium / Q000378:metabolism*
D001786:Blood Glucose; D002951:Citrates; D005230:Fatty Acids, Nonesterified; D007773:Lactates