[Drug-induced systemic lupus erythematosus (SLE)].
Oral administration of anticonvulsive drugs like hydantoin can induce a syndrome similar to systemic lupus erythematosus (SLE). This syndrome is characterized by development of typical symptoms or signs of SLE following the drug administration, occurrence of a significant elevation of ANA titer (above 1:40), and clinical remission after dropping the anticonvulsive treatment. A patient is reported and the typical clinical features and laboratory (mainly serological) findings of hydantoin-induced SLE are discussed. The potentially SLE-inducing drugs are reviewed.
D002648:Child; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D006827:Hydantoins / Q000009:adverse effects; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced* / Q000473:pathology; D013577:Syndrome; D013997:Time Factors
D006827:Hydantoins
Medikamentös induzierter systemischer Lupus erythematodes (SLE).