Effects of phenylhydroxylamine and aminophenols in Japanese quail in vivo.
1. The effects of phenylhydroxylamine, and o- and p-aminophenol were studied in the Japanese quail. 2. Symptoms normally observed in aniline-treated birds were seen in quail after phenylhydroxylamine dosage at > 10 mg/kg. Aminophenols (up to 50 mg/kg) did not give these symptoms. 3. Injection of phenylhydroxylamine (50 mg/kg) resulted in formation of 70% ferrihaemoglobin after 5 min, following which a rapid reduction of ferrihaemoglobin was observed. 4. Phenylhydroxylamine reached highest blood concn. of 0.2 mumol/ml after 5 min. Phenylhydroxylamine was reduced to aniline within 5 min. 5. The effects of aniline in vivo are most probably due to O2 shortage caused by ferrihaemoglobin formation.
D000627:Aminophenols / Q000494:pharmacology*; D000814:Aniline Compounds / Q000097:blood; D000818:Animals; D003370:Coturnix / Q000097:blood*; D006898:Hydroxylamines / Q000097:blood / Q000494:pharmacology*; D008706:Methemoglobin / Q000096:biosynthesis; D008708:Methemoglobinemia / Q000139:chemically induced*; D011784:Quail / Q000097:blood*
D000627:Aminophenols; D000814:Aniline Compounds; D006898:Hydroxylamines; C027667:2-aminophenol; C012484:phenylhydroxylamine; D008706:Methemoglobin; C026729:4-aminophenol