[Messenger RNA in cases of heterozygous beta and delta-beta Thalassemia. Biosynthetic and hybridization studies].
mRNA-cDNA hybridization, intact reticulocytes biosynthesis and heterologous cell-free translation studies have been performed in cases of heterozygous beta and delta beta thalassaemia. Results obtained have shown that the relative amount of beta mRNA is higher in Ferrara microcytes than in other heterozygous including delta beta. This indicates that transcription of beta globin gene takes place in Ferrara beta 0 thalassaemia. On the contrary globin biosynthesis studies have failed to show clear-cut differences among the various heterozygous considered and cannot evaluate the translatability of beta thal. FemRNA.
D002474:Cell-Free System; D005914:Globins / Q000096:biosynthesis; D006579:Heterozygote; D006801:Humans; D009693:Nucleic Acid Hybridization; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000378:metabolism*; D012156:Reticulocytes / Q000378:metabolism; D013789:Thalassemia / Q000235:genetics / Q000378:metabolism*
D012333:RNA, Messenger; D005914:Globins
L'RNA messaggero in alcune forme eterozigoti di beta E delta beta talassemia. Studi biosintetici e di ibridazione.