Intravascular papillary endothelial hyperplasia in the skin and subcutaneous tissue.
Twenty-four cases of Intravascular Papillary Endothelial Hyperplasia (IPEH) have been studied. IPEH comprises approximately 2% of benign and malignant vascular tumours of the skin and subcutaneous tissue. This peculiar tumour-like process lacks specific clinical characteristics and its diagnosis must be based on microscopic examination. Histologically is is characterised by a papillary proliferation of endothelial cells forming vascular channels, commonly associated with thrombus and in some cases simulating angiosarcoma.--Follow-up of 10 cases indicates a benign clinical course.
D000328:Adult; D000798:Angiomatosis / Q000473:pathology*; D001808:Blood Vessels / Q000473:pathology; D004727:Endothelium; D005260:Female; D006801:Humans; D006965:Hyperplasia; D012867:Skin / Q000098:blood supply; D012878:Skin Neoplasms / Q000473:pathology