Levamisole augmentation of PPD-induced lymphocyte proliferation.
The effect of levamisole (LMS) on PPD-induced lymphocyte proliferation in vitro has been investigated in 12 patients with pulmonary tuberculosis and 7 healthy tuberculin-positive control subjects. The augmentative effect of LMS was variable when used directly in vitro and also after pre-incubation of the donor cells with LMS. After ingestion of a single 150 mg dose of LMS, lymphocytes from the control subjects showed significant increased responses in PHA- and PPD-induced lymphocyte proliferation.
D006801:Humans; D007978:Levamisole / Q000494:pharmacology*; D008213:Lymphocyte Activation; D008218:Lymphocytosis / Q000139:chemically induced*; D014397:Tuberculosis, Pulmonary / Q000097:blood*
D007978:Levamisole