Non-diabetic necrobiosis lipoidica. Hitherto unrecognized papulonecrotic, nodulo-ulcerative and familial forms of the disease.
Necrobiosis lipoidica of the legs, in which deep ulcers resembling erythema induratum, gummas or a variety of other chronic progressive ulcerating skin diseases occur, is described. In 2 cases the lesions were precipitated by a crush injury elsewhere in the same leg, but not at the site of the ultimate lesions. In 2 further pairs of siblings the same problem arose as a familial complaint without trauma. These cases were distinguished by severe necrosis in the absence of diabetes.
D000328:Adult; D005260:Female; D006801:Humans; D007871:Leg Ulcer / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009335:Necrobiosis Lipoidica / Q000209:etiology / Q000235:genetics* / Q000473:pathology; D013997:Time Factors