Substantiation of methodical approaches to the evaluation of late consequences of exposure to chemical compounds.
The basic principles of experimental evaluation of the gonadotropic, mutagenic, embryotropic and blastomogenic effects of chemical compounds and late consequences of their effects on the cardiovascular system are discussed. The mentioned aspects of late (delayed) effects of contact with industrial poisons are highly topical with respect to the considerable prevalence of the corresponding morbidity in all countries. On the basis of the authors' experience, schemes of setting up the corresponding experiments, conditions of their performance, time of observation the most important methods, etc., are proposed. The use of the proposed methodological approaches was verified in the study of several scores of chemical compounds and this permitted the authors to work out the basic criteria for the assessment of late effects of industrial poisons in hygienic limitation of their content in the external environment.
D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D004785:Environmental Pollutants / Q000633:toxicity*; D006801:Humans; D009154:Mutation / Q000187:drug effects; D009369:Neoplasms / Q000139:chemically induced; D009787:Occupational Medicine / Q000379:methods*; D012098:Reproduction / Q000187:drug effects; D013997:Time Factors
D004785:Environmental Pollutants