Detrusor dynamics. II. Effect of prostaglandins and their synthesis inhibitor on stress-relaxation time course.
The influence of prostaglandin F2 alpha (PGF2 alpha) and E2 (PGE2) and their synthesis inhibitor indomethacin on the stress-relaxation time course was studied in 65 cat detrusor strips. Small doses of prostaglandins (0.5 to 2 micrograms per ml) decreased the ability of strips to relax after isometric stretch and thus decreased the relaxation rate constant. A dose of 4 micrograms per ml produced uncompensated hypotonia with PGE2 and mild hypotonia which recovered at the end of the relaxation phenomenon with PGF2 alpha. Although indomethacin (2 micrograms per ml) produced an overall increase in the relaxation ability of the strips, the initial phase of relaxation was associated with a decreased relaxation rate constant and some rigidity in the strip which may have been attributable to nonintracellular accumulation of electrolytes.
D000818:Animals; D001696:Biomechanical Phenomena; D002415:Cats; D005260:Female; D007213:Indomethacin / Q000494:pharmacology*; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D011458:Prostaglandins E / Q000494:pharmacology*; D011460:Prostaglandins F / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects* / Q000502:physiology
D011458:Prostaglandins E; D011460:Prostaglandins F; D007213:Indomethacin