The ontogeny of erythropoiesis in the mouse detected by the erythroid colony-forming technique. II. Transition in erythropoietin sensitivity during development.
The erythroid colon-forming technique has been used to study the erythropoietin (Ep) sensitivity of CFU-E during ontogenesis. Evidence is provided which indicates that an age-related decreasing Ep sensitivity of CFU-E occurs as the animal develops. In addition, an intermediate Ep-sensitive CFU-E population represented by the 2-day-old neonate is present during the transition from foetus to adult. The Ep sensitivity of the foetal, neonatal and adult CFU-E populations is shown to be an intrinsic property of these populations.
D000375:Aging; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004305:Dose-Response Relationship, Drug; D004920:Erythropoiesis / Q000187:drug effects*; D004921:Erythropoietin / Q000494:pharmacology*; D005260:Female; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000187:drug effects
D004921:Erythropoietin