Antibodies to lens antigens in cataract and after cataract surgery.
By means of an enzyme-linked immunosorbent assay (ELISA) antibodies to whole lens homogenate were found in 50.0% of 38 patients with senile cataract and in 57.3% of 75 controls. The antibody titres were in the range of 10-160 in both groups. IgG antibodies occurred in 44.7% of patients and in 45.3% of controls, whereas IgM antibodies were found in 21.1% of the patients and in 40.0% of the controls (not significant). Postoperative uveitis occurred in 5 (31.6%) of 19 patients, who had antibodies in serum prior to the operation and in only 2 (10.5%) of 19 antibody-negative patients (P = 0.10).
D000328:Adult; D000368:Aged; D000906:Antibodies / Q000032:analysis*; D002386:Cataract / Q000276:immunology*; D002387:Cataract Extraction; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007908:Lens, Crystalline / Q000276:immunology* / Q000293:injuries; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000276:immunology; D014605:Uveitis / Q000276:immunology
D000906:Antibodies; D007074:Immunoglobulin G; D007075:Immunoglobulin M