["Granuloma pouch" reduction after treatment with indomethacin and diflunisal and collateral effects of these drugs on gastric mucosa].
In the present work it was determined the ability of non-steroidal anti-inflammatory drugs (Diflunisal and Indomethacin) to inhibit formation of "granuloma pouch" exudate induced in rats. This study shows that the combined administration of Diflunisal and Indomethacin exerts similar anti-inflammatory activity as the single drugs. There does not seem to be additive anti-inflammatory effects of the drugs in combination but, if anything, a weak antagonism. The association of the two compounds produces a reduced harmful effect on the gastric mucus.
D000818:Animals; D004061:Diflunisal / Q000627:therapeutic use*; D004195:Disease Models, Animal; D005753:Gastric Mucosa / Q000187:drug effects* / Q000503:physiopathology; D006099:Granuloma / Q000188:drug therapy*; D007213:Indomethacin / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D012459:Salicylates / Q000627:therapeutic use*; D013272:Stomach Diseases / Q000188:drug therapy*
D012459:Salicylates; D004061:Diflunisal; D007213:Indomethacin
Riduzione del "granuloma pouch" dopo trattamento con indometacina e diflunisal e loro effetti collaterali sulla mucosa gastrica.