The hypotensive action of 3-deaza-adenosine.
The effects of 3-deaza-adenosine on the cardiovascular system was investigated in normotensive (WKY) and spontaneously hypertensive rate (SHR). This compound (50 mg/kg i.p. 2X) significantly lowers blood pressure in both groups of animals, an effect which lasts for up to 2 h. The hypotensive effect is not affected by ganglion blockade, and appears to be due in part to a direct effect on blood vessels. While the response is similar to that seem with adenosine, it is more long-lasting. The results of this study suggest a potential role for this compound or analogues of its as possible antihypertensive agents.
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D005724:Ganglia / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006584:Hexamethonium Compounds / Q000494:pharmacology; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051381:Rats; D012263:Ribonucleosides / Q000494:pharmacology*; D013997:Time Factors; D014372:Tubercidin / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects
D006584:Hexamethonium Compounds; D012263:Ribonucleosides; C018258:3-deazaadenosine; D014372:Tubercidin