title: The problem of nonresponding estrogen receptor-positive patients with advanced breast cancer.
abstract: Patients with advanced breast cancer and low or poor concentration of estrogen receptors in tumor biopsies have little chance of responding to endocrine therapy. This problem was seen in a group of nonresponding estrogen receptor-positive (ER+) patients. Some comments on possible explanations for this phenomenon are made and suggestions to overcome it are given.
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D004359:Drug Therapy, Combination; D005189:False Positive Reactions; D005260:Female; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D009362:Neoplasm Metastasis; D011960:Receptors, Estrogen / Q000378:metabolism*; D012075:Remission, Spontaneous
chemical_list: D000970:Antineoplastic Agents; D006728:Hormones; D011960:Receptors, Estrogen