Are alveolar macrophages translocated to the lymph nodes?
Hilar lymph nodes from 5 rabbits exposed for 3 months (5 days/week, 6 h/day) to metallic nickel dust (1.2 mg/m3) and from 2 controls were studied with electron microscopy. Some lymph node macrophages were filled with laminated bodies and had a vesiculated cytoplasm, a well developed endoplasmic reticulum and a few of them contained nickel particles as well. This means that they appeared identical to macrophages found in alveoli in nickel exposed rabbits. We propose that there is a transport of alveolar macrophages to the lymph nodes in nickel exposed rabbits.
D000818:Animals; D002465:Cell Movement; D004391:Dust; D008198:Lymph Nodes / Q000648:ultrastructure*; D008264:Macrophages / Q000502:physiology / Q000648:ultrastructure*; D008297:Male; D009532:Nickel / Q000009:adverse effects; D011009:Pneumoconiosis / Q000209:etiology / Q000473:pathology; D011650:Pulmonary Alveoli / Q000648:ultrastructure*; D011817:Rabbits
D004391:Dust; D009532:Nickel