Kidney disease.
The diagnostic highlights under electron microscopy in hereditary nephropathies and glomerulonephritides are reviewed: Alport's syndrome--lamellation, fragmentation and reticulation of glomerular basement membrane; benign essential (familial) hematuria--glomerular basement membrane thinning; nail patella syndrome--moth eaten holes and collagen like fibrils in glomeruli; nephronophthisis--thickening, thinning, reticulation and loss of tubular basement membrane; intramembranous and epimembranous glomerulonephritis--unequivocal diagnosis in early and late stages; extracapillary glomerulonephritis--exact classification of the basic type of glomerulonephritis; segmental focal sclerosing glomerulonephritis--unequivocal diagnosis of early stages and differentiation from other forms of glomerulonephritis or other nephropathies; Schönlein-Henoch's syndrome--scanty subepithelial deposits encases by a thin lamella of lamina densa; SLE--deciphering mixed forms of glomerulonephritis and demonstration of virus-like tubular structures in endothelium, so-called organized deposits, interstitial immunocomplex nephritis; mixed IgG/IgM cryoglobulinaemia--crystalloid structure of deposits; IgA nephritis--unequivocal demonstration of mesangial deposits; congenital nephrotic syndrome--irregularity of glomerular basement membrane and finally amyloidosis--unequivocal diagnosis. It is concluded that electron microscopy contributes information of clinical relevance in 30% of cases. Thus, electron microscopy should be used (in addition to light microscopy and immunofluorescence), whenever a renal biopsy specimen is to be critically evaluated.
D003450:Cryoglobulins; D005921:Glomerulonephritis / Q000473:pathology; D006417:Hematuria / Q000473:pathology; D006801:Humans; D011695:IgA Vasculitis / Q000473:pathology; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007668:Kidney / Q000648:ultrastructure; D007674:Kidney Diseases / Q000473:pathology*; D008180:Lupus Erythematosus, Systemic / Q000473:pathology; D008854:Microscopy, Electron; D009261:Nail-Patella Syndrome / Q000473:pathology; D009393:Nephritis / Q000473:pathology; D009394:Nephritis, Hereditary / Q000473:pathology; D009404:Nephrotic Syndrome / Q000473:pathology; D010265:Paraproteinemias / Q000473:pathology
D003450:Cryoglobulins; D007074:Immunoglobulin G; D007075:Immunoglobulin M