[Effect of chlorpromazine, lidocaine and procaine on the electrophoretic mobility of rat erythrocytes].
The authors examined the influence of chlorpromazine on the electrophoretic motility of erythrocytes by means of the method of microelectrophoresis. The results were compared with data, obtained from analogous studies on the effect of local anaesthetics (procaine and lidocaine) on erythrocyte membranes. Erythrocytes (6.10(8) erythrocytes/ml) were incubated at temperature of 20 degrees C for a period of 15 minutes. They found that erythrocytes diminished their electrophoretic motility after incubation with labilizing concentration (10(-5M) of chlorpromazine as well as of procaine and lidocaine, but after treatment with stabilizing concentration (10-7M) they increased their electrophoretic motility. The obtained results showed that there was a reverse dependence between the hemolytic and pharmacological action of these three preparations and the change, which they induced on the superficial electrical charge-a greater change in the superficial electric charge induced those, which were weaker hemolytics and had weaker pharmacological effect.
D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology*; D004586:Electrophoresis / Q000379:methods; D004910:Erythrocyte Membrane / Q000187:drug effects; D004912:Erythrocytes / Q000187:drug effects*; D005260:Female; D008012:Lidocaine / Q000494:pharmacology*; D008297:Male; D011343:Procaine / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
D011343:Procaine; D008012:Lidocaine; D002746:Chlorpromazine
Vliianie na khlorpromazin, lidokain i prokain vûrkhu elektroforetichnata podvizhnost na eritrotsiti ot plûkh.