Heterogeneity of the haemoglobin-A1c-band in isoelectric focussing.
A double HbA1c-band was demonstrated in isoelectric focussing of blood from diabetics with a fasting blood glucose above 11 mmol/l. The same band-doubling was also demonstrated after incubation of erythrocytes in glucose/saline solutions. This finding may reflect the presence of the initial condensation product between haemoglobin and glucose, the Schiff-base intermediate.
D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis* / Q000378:metabolism; D002648:Child; D003920:Diabetes Mellitus / Q000097:blood*; D006441:Hemoglobin A / Q000032:analysis* / Q000378:metabolism; D006801:Humans; D007525:Isoelectric Focusing; D008875:Middle Aged; D012545:Schiff Bases
D001786:Blood Glucose; D012545:Schiff Bases; D006441:Hemoglobin A