Sorption of cholesterol and other bile components on ion-exchangers in vitro, and their influence on the cholesterol level in human serum in vivo.
The sorption of bile acids, bilirubin, bilirubin glucuronates and cholesterol on ion-exchange resin is described. After some successful attempts of sorption of these substances from human and animal bile in vitro, this exchanger has been used in human therapy. Positive results obtained showed the usefulness of the method. The purpose of the experiments was to study the usefulness of ion-exchangers for sorption of bile components of bile acids, bilirubin, bilirubin glucuronates and cholesterol. First sorption was carried out on human and animal bile, on Zerolit-FS-ip, in cycles (OH-) and (Cl-), by passing through glass columns downwards and some of them by mixing the bile with ion-exchange resin. Zerolit FS-ip is an organic sorbent, a scavenger, a strongly basic macroporous, anion exchanger. Positive results of these sorptions indicated the possibility of using this method in therapy of disturbed lipid conditions.
D000328:Adult; D000368:Aged; D000818:Animals; D001161:Arteriosclerosis / Q000378:metabolism; D001646:Bile / Q000032:analysis*; D001647:Bile Acids and Salts / Q000302:isolation & purification* / Q000378:metabolism; D001663:Bilirubin / Q000302:isolation & purification* / Q000378:metabolism; D002784:Cholesterol / Q000097:blood* / Q000302:isolation & purification*; D005260:Female; D005965:Glucuronates / Q000302:isolation & purification* / Q000378:metabolism; D006801:Humans; D006937:Hypercholesterolemia / Q000378:metabolism; D006951:Hyperlipoproteinemias / Q000378:metabolism; D066298:In Vitro Techniques; D007408:Intestinal Absorption; D007475:Ion Exchange Resins; D008077:Lipoproteins, LDL / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011817:Rabbits
D001647:Bile Acids and Salts; D005965:Glucuronates; D007475:Ion Exchange Resins; D008077:Lipoproteins, LDL; D002784:Cholesterol; D001663:Bilirubin