title: [Electron microscopic study of the antiviral action of bonafton in experimental influenza infection].
abstract: Action of bonaphthon on influenza A virus was studied in experimental influenzal pneumonia of mice. Bonaphthon was shown to lower 1.5-2 fold the reproduction of influenza virus in pulmonary tissue as compared with control. It is suggested that the mechanism of bonaphthon action may be due both to the inhibition of the synthesis of virus-specific membrane protein by the cells and to disordered transport of this polypeptide to the cell membranes. Bonaphthon proved to exert the most favorable effect in the course of its preventive administration in the early stages of infection.
mesh_terms: D000818:Animals; D000998:Antiviral Agents; D004353:Drug Evaluation, Preclinical; D009980:Influenza A virus / Q000187:drug effects / Q000648:ultrastructure; D008168:Lung / Q000187:drug effects / Q000648:ultrastructure; D051379:Mice; D008854:Microscopy, Electron; D009285:Naphthoquinones / Q000494:pharmacology / Q000627:therapeutic use*; D009976:Orthomyxoviridae Infections / Q000188:drug therapy* / Q000473:pathology
chemical_list: D000998:Antiviral Agents; D009285:Naphthoquinones; C011180:bonafton
vernacular_title: Elektronno-mikroskopicheskoe izuchenie protivovorusnogo deĭstviia bonaftona pri éksperimental'noĭ grippoznoĭ infektsii.