Unilateral 5,7-dihydroxytryptamine lesions of the dorsal raphe nucleus (DRN) and rat rotational behaviour.
A unilateral lesion in the dorsal raphe nucleus (DRN) resulted in a decreased concentration of 5-hydroxytryptamine (5-HT) in the ipsilateral striatum (CS), anterior cortex and substantia nigra (SN), a loss of [3H]5-HT uptake sites in the cortex and striatum and a selective reduction in 5-HT turnover in the substantia nigra. The directly acting 5-HT agonist 5-methoxy-N,N-dimethyltryptamine induced contralateral turning behaviour in the lesioned animals, whilst the 5-HT releasing agent, p-chloroamphetamine, induced ipsilateral rotation. All rotational behaviour was blocked by haloperidol and the turning behaviour in response to 5-MeODMT was blocked by methysergide. The data presented suggest that the DRN innervates the SN and CS differentially and that nigral 5-HT receptors become supersensitive after denervation of the DRN-SN pathway.
D015116:5,7-Dihydroxytryptamine / Q000494:pharmacology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001933:Brain Stem / Q000187:drug effects*; D003342:Corpus Striatum / Q000502:physiology; D004102:Dihydroxytryptamines / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D008297:Male; D008732:Methoxydimethyltryptamines / Q000494:pharmacology; D009638:Norepinephrine / Q000378:metabolism; D011903:Raphe Nuclei / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism; D013378:Substantia Nigra / Q000502:physiology; D010133:p-Chloroamphetamine / Q000494:pharmacology
D004102:Dihydroxytryptamines; D008732:Methoxydimethyltryptamines; D011985:Receptors, Serotonin; D015116:5,7-Dihydroxytryptamine; D012701:Serotonin; D010133:p-Chloroamphetamine; D004298:Dopamine; D009638:Norepinephrine