Prevention of chromosomal breakage in Fanconi's anemia by cocultivation with normal cells.
The frequency of aberrations in cultured lymphocytes from patients with Fanconi's anemia was significantly reduced when the cells were cocultivated with normal human lymphocytes. The results suggest that most of the chromosomal aberrations observed in cultured cells from Fanconi patients arise during cultivation and that the presence of normal cells prevents chromosomal damage by means of a hitherto unknown mechanism.
D000741:Anemia, Aplastic / Q000235:genetics*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005199:Fanconi Anemia / Q000235:genetics* / Q000473:pathology; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure*