Rimantadine hydrochloride blocks the second step of influenza virus uncoating.
Two steps of influenza virus A/WSN uncoating in MDCK cells are described. The products of the first step are cores which accumulate in the nuclear-associated cytoplasm. The products of the second step are ribonucleoproteins which penetrate the nuclei. Rimantadine blocks the second step without interfering with the first one.
D000218:Adamantane / Q000031:analogs & derivatives*; D000327:Adsorption; D000818:Animals; D002460:Cell Line; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D004285:Dogs; D009980:Influenza A virus / Q000187:drug effects* / Q000378:metabolism; D012261:Ribonucleoproteins / Q000378:metabolism; D012299:Rimantadine / Q000494:pharmacology*; D014764:Viral Proteins / Q000378:metabolism
D012261:Ribonucleoproteins; D014764:Viral Proteins; D012299:Rimantadine; D000218:Adamantane