title: Enhanced immunogenicity of xenogenized tumor cells in rats pretreated with cyclophosphamide.
abstract: Immunization with xenogenized tumor cells, tumor cells infected with murine leukemia viruses, produced strong antitumor immunity. In this study, the immunogenicity of xenogenized tumor cells was compared in cyclophosphamide-treated and non-treated rats. CY treatment 3 days before immunization with xenogenized tumor cells enhanced antitumor cell-mediated immunity and antibody responses. However, CY treatment after immunization had no effect. Transfer of thymus cells form normal rats before the tumor challenge abolished the CY-induced augmenting effect. From these results, it is suggested that the elimination of precursors of suppressor T-cells by CY treatment results in enhanced immunogenicity of xenogenized tumor cells.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000276:immunology*; D051381:Rats; D014181:Transplantation Immunology; D014184:Transplantation, Homologous
chemical_list: D003520:Cyclophosphamide