title: Serial changes in renal haemodynamics during normal human pregnancy.
abstract: Effective renal plasma flow (ERPF) and glomerular filtration rate (GFR) were determined at constant intervals during and after the normal pregnancies in 25 healthy women. Compared with non-pregnant values, ERPF increased by 80 percent during early pregnancy but fell significantly from this new level during the third trimester. GFR, however, remained at a level 50 per cent above the non-pregnant throughout pregnancy. Filtration fraction (GFR/ERPF) was significantly reduced during early pregnancy but rose to a value equivalent to the non-pregnant during the third trimester. Comparable data of previous workers are re-interpreted.
mesh_terms: D000328:Adult; D005260:Female; D005865:Gestational Age; D005919:Glomerular Filtration Rate; D006439:Hemodynamics; D006801:Humans; D007668:Kidney / Q000098:blood supply*; D011247:Pregnancy; D012039:Regional Blood Flow