An impurity, N10-methylfolate, associated with methotrexate inhibits folate binding in milk and serum.
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism*; D002417:Cattle; D004340:Drug Contamination; D005492:Folic Acid / Q000097:blood / Q000378:metabolism*; D066298:In Vitro Techniques; D007700:Kinetics; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008894:Milk Proteins / Q000378:metabolism*; D011485:Protein Binding / Q000187:drug effects
D001798:Blood Proteins; D008894:Milk Proteins; C028162:N(10)-methylfolate; D005492:Folic Acid; D008727:Methotrexate