[Assay of brain and liver DNA, determination of body growth and of some blood parameters in rats subjected to protein malnutrition during fetal and post-natal development].
The Authors studied the effects of proteinic malnutrition when it occurred at various periods in the life of rats: the last 10 days of fetal life; nursing (the first 3 weeks of life); after weaning (up to 42 day). The results show that:--the growth in weight of the animals was severely restrained when protein deficiency occurred in post-natal life;--in any case, the blood levels of hematocrit, hemoglobin and proteins were significantly lowered;--organ functions and development were greatly compromised if malnutrition occurred during the period of their cell division. In fact, a brain damage, estimated by protein and DNA modifications, is the result of protein deficiency in pre-natal and, particularly, in nursing period. The hepatic damage, instead, becomes more evident in post-natal life and specially after weaning since the cell division in the liver continues for a much longer period of time.
D000375:Aging; D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D001835:Body Weight; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D004247:DNA / Q000032:analysis*; D005260:Female; D006400:Hematocrit; D008099:Liver / Q000032:analysis* / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications / Q000503:physiopathology*; D011488:Protein Deficiency / Q000503:physiopathology*; D051381:Rats
D001798:Blood Proteins; D004247:DNA
Dosaggi del DNA cerebrale ed epatico, determinazione degli accrescimenti ponderali e di alcuni parametri ematici in ratti sottoposti a malnutrizione proteica durante lo sviluppo fetale e post-natale.