Endosulfan intoxication: Blood glucose, electrolytes, Ca levels, ascsorbic acid and glutathione in rats.
Endosulfan-induced changes in blood glucose, plasma electrolytes, and blood and brain ascorbic acid, hexokinase and glutathione have been investigated following acute and subacute administration in 12 h fasted male rats. After a single oral dose of endosulfan (40 mg/kg) a significant increase in blood glucose, blood ascorbic acid, and blood and brain glutathione was observed. The maximum increase in blood was observed at 2 h (36%). Increase in blood and brain glutathione was highly significant at 4 h (50 and 43%, respectively). The blood ascorbic acid slowly increased by 19% over control during the treatment period. No significant change in brain hexokinase was observed. Repeated oral administration of endosulfan (0.625 to 20 mg/kg) for 7 weeks had no effect on plasma sodium and potassium. At the highest dose (20 mg/kg), blood glucose was slightly increased (16%). Plasma Ca was significantly decreased, the maximum fall (35%) being observed at 4 h.
D000818:Animals; D001205:Ascorbic Acid / Q000032:analysis* / Q000097:blood*; D001786:Blood Glucose / Q000032:analysis*; D001921:Brain / Q000201:enzymology; D001923:Brain Chemistry; D002118:Calcium / Q000097:blood*; D004726:Endosulfan / Q000506:poisoning*; D005978:Glutathione / Q000032:analysis / Q000097:blood*; D006593:Hexokinase / Q000032:analysis; D008297:Male; D051381:Rats
D001786:Blood Glucose; D006593:Hexokinase; D005978:Glutathione; D004726:Endosulfan; D001205:Ascorbic Acid; D002118:Calcium