Acquired cystic disease of the kidney and renal cell carcinoma on long term hemodialysis four surgical cases of young adults in Japan.
Four surgical cases of acquired cystic disease of the kidney in the third decade are reported, which include renal cell carcinoma in three patients and multiple adenomas and cystadenomas in all patients. The intervening parenchyma of these kidneys was disorganized as end stage kidney and numerous cysts were found in both kidneys. Some of the cysts were lined by hyperplastic epithelium consisting of clear and granular cells arranged in piled up and papillary fashion. These cysts were diagnosed as cystadenoma. Multiple solid adenomas of a 28-year-old male on hemodialysis for 6 years were of various size as if arranged in developing stage of the growth. Summing up all cases included in the literature, the mean duration of hemodialysis of the cases with renal tumor was 5.2 years, while 2.9 years without tumor. With increase of duration of hemodialysis, acquired cystic disease of the kidney is exposed to a high risk of developing malignancy.
D000230:Adenocarcinoma / Q000150:complications / Q000601:surgery*; D000236:Adenoma / Q000150:complications / Q000601:surgery*; D000328:Adult; D005260:Female; D006801:Humans; D007668:Kidney / Q000473:pathology; D052177:Kidney Diseases, Cystic / Q000150:complications / Q000601:surgery*; D007680:Kidney Neoplasms / Q000150:complications / Q000601:surgery*; D008297:Male; D006435:Renal Dialysis