Effect of hydroxy acids on hypercholesterolaemia in rats.
Hydroxy acids (aliphatic and aromatic) which are present in legumes were added as supplements to a diet causing hypercholesterolaemia in rats. Ferulic, p-coumaric, phytic and uronic acids showed hypolipidemic activity while vanillic, caffeic and cinnamic acids did not. The trace mineral content of serum was not affected by these acids.
D000818:Animals; D000924:Anticholesteremic Agents; D002109:Caffeic Acids / Q000627:therapeutic use; D002934:Cinnamates / Q000627:therapeutic use*; D003373:Coumaric Acids / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D006880:Hydroxy Acids / Q000627:therapeutic use*; D006937:Hypercholesterolemia / Q000188:drug therapy*; D010833:Phytic Acid / Q000627:therapeutic use; D051381:Rats; D014574:Uronic Acids / Q000627:therapeutic use; D014641:Vanillic Acid / Q000627:therapeutic use
D000924:Anticholesteremic Agents; D002109:Caffeic Acids; D002934:Cinnamates; D003373:Coumaric Acids; D006880:Hydroxy Acids; D014574:Uronic Acids; D010833:Phytic Acid; C004999:ferulic acid; D014641:Vanillic Acid