title: Malabsorption and gastric hyperacidity in systemic mastocytosis. Results of cimetidine therapy.
abstract: Visceral infiltration by mast cells (systemic mastocytosis) is an unusual manifestation of cutaneous mastocytosis. Symptomatic gastrointestinal disease occurs in approximately one-fourth of patients having systemic mastocytosis. An unusual gastrointestinal complication is malabsorption, described in sporadic case reports. A patient with gastric acid hypersecretion and malabsorption is described. Treatment using the histamine H2 antagonist, cimetidine, ameliorated the patient's gastrointestinal symptoms; however, the malabsorption was not resolved.
mesh_terms: D002446:Celiac Disease / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D002927:Cimetidine / Q000627:therapeutic use*; D005745:Gastric Acidity Determination; D005750:Gastric Juice / Q000378:metabolism*; D006146:Guanidines / Q000627:therapeutic use*; D006801:Humans; D007579:Jejunal Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D007583:Jejunum / Q000473:pathology; D008297:Male; D008875:Middle Aged; D014582:Urticaria Pigmentosa / Q000150:complications*
chemical_list: D006146:Guanidines; D002927:Cimetidine