title: [Clinicopharmacologic study of blood carbamazepine levels in a group of epileptic patients].
abstract: Clinico-pharmacological evaluation on Carbamazepine serum levels was performed in a group of epileptic patients. CBZ (Carbamazepine) blood levels have been detected in a heterogeneous group of epileptic patients taking several other antiepileptic drugs. Patients in which there was a good reduction of epileptic seizures after CBZ was added, had a mean blood level of 4.2 plus or minus 1.4 microgram/ml. When Dyphenilhydantoine (DPH) and/or Phenobarbital (PB) were associated with CBZ they both decreased CBZ blood levels; on the contrary CBZ did not appear to modify DPH and PB blood levels.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002220:Carbamazepine / Q000008:administration & dosage / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008875:Middle Aged; D010634:Phenobarbital / Q000008:administration & dosage; D010672:Phenytoin / Q000008:administration & dosage; D011324:Primidone / Q000008:administration & dosage
chemical_list: D011324:Primidone; D002220:Carbamazepine; D010672:Phenytoin; D010634:Phenobarbital
vernacular_title: Studio clinico-farmacologico sulle concentrazioni ematiche di carbamazepina in un gruppo di pazienti epilettici.