[Effect of central cholinolytics on conditioned reflex activity, pancreatic secretion and water diuresis].
During administration of amizil (0.3-0.6 mg/kg) and metamizil (0.1 mg/kg) there is a decrease in pancreatic secretion after ingestion of 100 g of meat, drinking of 600 ml of an aqueous-lactic mixture and irrigation of the duodenal mucosa with hydrochloric acid solution. Pancreatic secretion was completely suppressed in response to sham feeding. The time course of water-salt metabolism was disturbed: urination decreased during the first experimental hour. The cholinolytics did not produce such an effect on administration of the aqueous-lactic mixture directly into the stomach, avoiding the drinking. Research into the higher nervous activity has shown that even in a dose of 0.05 mg/kg amizil decreased the magnitude of conditioned and unconditioned salivation reflexes.
D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects*; D003864:Depression, Chemical; D004231:Diuresis / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D006613:Higher Nervous Activity / Q000187:drug effects; D010179:Pancreas / Q000187:drug effects* / Q000378:metabolism; D010276:Parasympatholytics / Q000494:pharmacology*; D011950:Receptors, Cholinergic / Q000187:drug effects
D010276:Parasympatholytics; D011950:Receptors, Cholinergic
Vliianie tsentral'nykh kholinolitikov na uslovnoreflektornuiu deiatel'nost', pozheludochnuiu sekretsiiu i vodnyĭ diurez.