[Influence of structure and physico-chemical properties of chemical agents in the induction of DNA alterations: nitrochlorobenzenes].
The DNA damage induced by mono-, di-, and trinitrochlorobenzenes has been evaluated in brain of male Swiss CD1 mice. The effect seems to be related to the increased content of nitro groups substituents on the chlorobenzene molecule. This class of compounds shows a high degree of specificity for the nervous tissue if compared to well-known carcinogens as NMU and NDMA.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D004247:DNA / Q000378:metabolism*; D004128:Dimethylnitrosamine / Q000494:pharmacology; D004137:Dinitrochlorobenzene / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D008770:Methylnitrosourea / Q000494:pharmacology; D051379:Mice; D009578:Nitrobenzenes / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D004137:Dinitrochlorobenzene; D009578:Nitrobenzenes; D008770:Methylnitrosourea; D004247:DNA; D004128:Dimethylnitrosamine
Funzione della struttura e delle proprieta' chimico-fisiche degli agenti chimici nell'induzione di alterazioni sul dna: nitroclorobenzeni.