Lack of platelet effect with the aspirin analog, salsalate.
Platelet function as determined by platelet aggregation and the release reaction was found to be normal in 8 patients receiving a nonacetylated analog of aspirin, salsalate, while all 5 aspirin controls had abnormal platelet function. Mean bleeding time in patients taking salsalate was less than that in aspirin controls. This study demonstrates that salsalate, which has anti-inflammatory activity and reduces prostaglandin synthesis, does not interfere with normal platelet function.
D001168:Arthritis / Q000097:blood / Q000188:drug therapy; D001241:Aspirin / Q000494:pharmacology; D001760:Bleeding Time; D001792:Blood Platelets / Q000378:metabolism*; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D012459:Salicylates / Q000494:pharmacology* / Q000627:therapeutic use; D012701:Serotonin / Q000378:metabolism*
D012459:Salicylates; D012701:Serotonin; D001241:Aspirin; C014182:salicylsalicylic acid