Cobalt-activated acylase and aminoacylase I in human malignant tumors.
The activities and isoenzyme pattern of cobalt-activated acylase and of aminoacylase I were estimated in carcinomas of bronchi, lung, thorax, stomach, colon and uterus. In all cancer tissues the activity of cobalt-activated acylase was markedly increased as compared with the normal tissue. Alterations of the isoenzyme pattern of cobalt-activated acylase were found in the carcinoma of stomach and of uterus, with the increased expression of the form-1 of the enzyme. No regularity in the aminoacylase I changes in tumor tissues has been observed.
D000581:Amidohydrolases / Q000032:analysis*; D000626:Aminopeptidases / Q000032:analysis*; D001943:Breast Neoplasms / Q000201:enzymology; D003035:Cobalt / Q000494:pharmacology*; D003110:Colonic Neoplasms / Q000201:enzymology; D004789:Enzyme Activation; D005260:Female; D005971:Glutamates / Q000032:analysis; D006801:Humans; D007527:Isoenzymes / Q000032:analysis; D008175:Lung Neoplasms / Q000201:enzymology; D009369:Neoplasms / Q000201:enzymology*; D013274:Stomach Neoplasms / Q000201:enzymology
D005971:Glutamates; D007527:Isoenzymes; D003035:Cobalt; D000626:Aminopeptidases; D000581:Amidohydrolases; C019672:aminoacylase I