Phlebitis induced by parenteral treatment with flucloxacillin and cloxacillin: a double-blind study.
Two studies were performed on a total of 54 patients with staphylococcal infections. Study I compares with phlebitogenic properties of flucloxacillin after intravenous infusions when either saline or sterile water was used as a solvent. No difference was observed between the two solvents, and the frequency of phlebitis for the total material without respect to solvents was 5% after 1 day of treatment and  13% after 2 days. Study II was a double-blind comparison of phlebitis caused by intravenous infusions of either flucloxacillin or cloxacillin. The frequencies of phlebitis were found to be 18 and 13%, respectively. After 2 days of treatment the frequency of phlebitis increased dramatically for both drugs. All infusions were given through a plastic cannula of 5-cm length and 1.2-mm diameter.
D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D003023:Cloxacillin / Q000008:administration & dosage / Q000009:adverse effects* / Q000031:analogs & derivatives*; D004311:Double-Blind Method; D005260:Female; D005436:Floxacillin / Q000009:adverse effects*; D006801:Humans; D007263:Infusions, Parenteral; D008297:Male; D008875:Middle Aged; D010689:Phlebitis / Q000139:chemically induced*; D013203:Staphylococcal Infections / Q000188:drug therapy
D005436:Floxacillin; D003023:Cloxacillin