title: Splenomegaly, hyperkinetic splenic flow and portal hypertension in colitis.
abstract: Four patients with a long history of colitis, splenomegaly, hypersplenism and portal hypertension were examined with angiography, both with contrast medium and isotopes, liver-spleen scintigraphy and recording of portal pressure. At angiography hyperkinetic splenic and portal blood flow was demonstrated. The increased flow causes increased portal pressure, which probably gives rise to changes in the liver often considered as slight cirrhosis at microscopy. The scintigraphic findings differed from Laennec cirrhosis. The liver uptake was homogeneous and no activity in the skeleton was recorded. Splenectomy cures both the hypersplenism and portal hypertension.
mesh_terms: D000328:Adult; D003093:Colitis, Ulcerative / Q000150:complications*; D006801:Humans; D006975:Hypertension, Portal / Q000000981:diagnostic imaging*; D008099:Liver / Q000000981:diagnostic imaging; D008102:Liver Circulation; D008297:Male; D008638:Mesenteric Arteries / Q000000981:diagnostic imaging; D008875:Middle Aged; D011859:Radiography; D011877:Radionuclide Imaging; D012039:Regional Blood Flow; D013154:Spleen / Q000098:blood supply* / Q000000981:diagnostic imaging; D013156:Splenectomy; D013163:Splenomegaly / Q000000981:diagnostic imaging*