Adverse responses to i.v. anaesthetics.
The adverse reactions to i.v. anaesthetics which occurred during a 3-yr period in one hospital were investigated. Sixteen reactions were reported; 13 of these occurred in a total of 7906 administrations of Althesin, two in 45 546 administrations of thiopentone and one in 630 administrations of methohexitone. The pathological process was identified in 10 patients. Most reactions were caused by activation of the alternate pathway for complement conversion.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000530:Alfaxalone Alfadolone Mixture / Q000009:adverse effects; D000771:Anesthesia, Intravenous / Q000009:adverse effects*; D000777:Anesthetics / Q000009:adverse effects*; D003170:Complement Pathway, Alternative / Q000187:drug effects; D005260:Female; D006801:Humans; D008297:Male; D008723:Methohexital / Q000009:adverse effects; D008875:Middle Aged; D011446:Prospective Studies; D013874:Thiopental / Q000009:adverse effects
D000777:Anesthetics; D000530:Alfaxalone Alfadolone Mixture; D008723:Methohexital; D013874:Thiopental