Conditions for albumin dimerisation in hephrotic urines. Dependence on an ultrafilterable factor.
At--14 degrees C the albumin in the urine of some patients with a nephrotic syndrome polymerises into dimer and higher polymers. This occurs at low ionic strengths within 1-3 days and in the pH range 5-10. For polymerisation both an altered albumin molecule and a low molecular weight ultrafilterable fraction in the urine are necessary. The appearance of both is probably related to steroid therapy. The ultrafiltrate fraction has molecular mass < 700, and is not peptide, amino acid, fatty acid or highly charged ion.
D000418:Albumins / Q000378:metabolism*; D000419:Albuminuria / Q000378:metabolism*; D004355:Drug Stability; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D046911:Macromolecular Substances; D009404:Nephrotic Syndrome / Q000378:metabolism*; D009994:Osmolar Concentration; D014462:Ultrafiltration; D014556:Urine / Q000032:analysis*
D000418:Albumins; D046911:Macromolecular Substances; D006854:Hydrocortisone