Regional distribution and production rate of 3-methoxy-4-hydroxyphenylethyleneglycol sulphate (MHPG-SO4) in rat brain.
The levels of noradrenaline (NA) and 3-methoxy-4-hydroxyphenylethyleneglycol sulphate (MHPG-SO4) in 15 brain regions showed a parallel distribution in male Wistar rats. The differences in regional distribution of MHPG-SO4 were similar to those in the rate of NA turnover reported by other investigators. The accumulation rates of MHPG-SO4 during 45 and 90 min after probenecid injection significantly correlated to the steady state levels of MHPG-SO4 in nine regions studied. With the results, the regional levels of MHPG-SO4 either in untreated or in probenecid-treated rats, are considered to be a useful index of NA turnover.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D006018:Glycols / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism; D007275:Injections, Intravenous; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D009830:Olfactory Bulb / Q000378:metabolism; D011149:Pons / Q000378:metabolism; D011339:Probenecid / Q000008:administration & dosage; D051381:Rats; D013116:Spinal Cord / Q000378:metabolism; D013788:Thalamus / Q000378:metabolism; D013997:Time Factors
D006018:Glycols; D008734:Methoxyhydroxyphenylglycol; D011339:Probenecid; D009638:Norepinephrine