Metabolic conversion of methotrexate in man.
Metabolism of methotrexate (MTX) to closely related analogues has been increasingly recognized in recent years. 7-Hydroxymethotrexate, 2,4-diamino-N10-methylpteroic acid, and methotrexate poly-gamma-glutamates have been established as products of metabolic conversion in man. The significance of the formation of these metabolites has not been firmly established. Certain of these compounds may play a role in the development of the renal failure syndrome associated with high-dose infusions, contribute to the chronic toxicity of MTX administration, and cross-react to a significant degree in radioimmunoassay methods for measurement of MTX concentrations.
D000918:Antibody Specificity; D001711:Biotransformation; D006801:Humans; D008727:Methotrexate / Q000276:immunology / Q000378:metabolism*; D010084:Oxidation-Reduction; D011863:Radioimmunoassay
D008727:Methotrexate