title: Synthesis and antibacterial activity of some ureido cephalexin and cefadroxil derivatives.
abstract: The antibacterial activity of some ureido, acylureido and carbamoylureido derivatives of cephalexin and cefadroxil, prepared in our laboratories, as compared to parent compounds is reported. Only the 7-[D-alpha-(imidazolidin-2-one-1-ylcarbonylamino)-alpha-phenylacetamido]-3-methyl-3-cephem-4-carboxylic acid (IV d) and the 7-[D-alpha-(imidazolidin-2-one-1-ylcarbonylamino)-alpha-p-hydroxyphenylacetamido]-3-methyl-3-cephem-4-carboxylic acid (V c) showed some antibiotic activity. However we found no activity improvement against Pseudomonas strains (contrary to the results obtained in similar penicillin derivatives) and a lower beta-lactamase resistance.
mesh_terms: D001419:Bacteria / Q000187:drug effects*; D002434:Cefadroxil; D002506:Cephalexin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology; D002511:Cephalosporins / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D002511:Cephalosporins; D002434:Cefadroxil; D002506:Cephalexin