title: Compensatory increase of responses to nerve stimulation of the partially denervated rat urinary bladder.
abstract: The rat urinary bladder was deprived of half of its innervation by removing the pelvic ganglion on one side. The motor response of such a partially denervated bladder to stimulation of the pelvic nerve on the other side were examined 1 week, 1 month and 2 months postoperatively. On all three occasions the increase in pressure of the operated bladder was larger than that of the control bladder; the enlargement was most marked 2 months after operation. The responses were further enlarged by eserine, and markedly reduced by atropine. The present results combined with those of previous investigations, showing a rapid recovery in the activity of the acetylcholine forming enzyme from a reduced level and a transient supersensitivity to chemical stimuli after unilateral removal of the pelvic ganglion, suggest that the enlarged responses to nerve stimulation 1 week postoperatively are mainly due to sensitization, while those observed at the later stages are due to collateral sprouting from the cholinergic nerve fibres of the intact pelvic nerve.
mesh_terms: D000320:Adrenergic Fibers / Q000502:physiology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D002799:Cholinergic Fibers / Q000502:physiology*; D004087:Dihydroergotamine / Q000494:pharmacology; D004558:Electric Stimulation; D005726:Ganglia, Parasympathetic / Q000502:physiology; D008297:Male; D008365:Manometry; D009046:Motor Neurons / Q000502:physiology; D009119:Muscle Contraction / Q000187:drug effects; D009121:Muscle Denervation; D009416:Nerve Regeneration; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D001743:Urinary Bladder / Q000294:innervation*
chemical_list: D004087:Dihydroergotamine; D001285:Atropine; D010830:Physostigmine