[Disorders of erythropoiesis in alcoholic ketoacidosis in patients with chronic liver diseases].
To evaluate the toxic effect of ethanol on erythropoiesis in alcoholic ketoacidosis (AK), 6 male patients were studied in the acute and remittent phase of AK. Episodes of metabolic acidosis in nondiabetic chronic alcoholics were associated with protracted vomiting and prolonged intestinal symptoms. AK was associated with elevated beta-hydroxybutyrate, acetoacetate and lactate/pyruvate plasma levels. Analysis of plasma lipids showed raised HDL cholesterol, fatty acids and phospholipids resulting in a concomitant disorder of lipid metabolism in red cell ghosts. A red cell metabolic disorder with reduced ATP and glutathione levels was also observed in patients suffering from mild hemolytic anemia. On admission, miscellaneous toxic effects on erythropoiesis were detected when bone marrow was aspirated. This study lends further support to the hypothesis that there is a linkage of different factors producing serious but transient hematologic and oncologic implications of ethanol in patients with AK.
D000138:Acidosis / Q000150:complications*; D000328:Adult; D000743:Anemia, Hemolytic / Q000209:etiology*; D002784:Cholesterol / Q000097:blood; D005227:Fatty Acids / Q000097:blood; D006801:Humans; D007651:Keto Acids; D008107:Liver Diseases / Q000150:complications*; D008297:Male; D010743:Phospholipids / Q000097:blood; D014280:Triglycerides / Q000097:blood
D005227:Fatty Acids; D007651:Keto Acids; D010743:Phospholipids; D014280:Triglycerides; D002784:Cholesterol
Erythropoiesestörungen alkoholtoxischer Ketoazidosen bei chronischen Lebererkrankungen.