title: Antiesterase activity of chlorphenvinphos and phospholine in certain rat tissues after administration by different routes.
abstract: The reported investigations were carried out on female Wistar rats receiving chlorphenvinphos and phospholine in doses equalling 3/4 LD50 onto the skin and intragastrically. the levels of acetylcholinesterase (AChE) were determined in the erythrocytes, liver and tibialis muscle and in three brain areas: pontomedullary area, hypothalamus and cerebral cortex. The activity of the enzyme was determined 15 and 30 minutes, and 3, 24 and 72 hours after poisoning. A high degree of AChE inhibition was observed in the brain after chlorphenvinphos poisoning (activity fall to 15--30%) and a slight decrease of AChE activity after administration of phospholine independently of the route. After oral poisoning with both preparations the AChE activity level in the erythrocytes was from about 27% to 31%, in the liver from 18 to 23%, and in the skeletal muscle from 51 to 54%, while with the transcutaneous route of poisoning these values were: 18--23%, 41--52%, and 36--48% respectively. A high degree of enzyme restoration was observed during 72 hours of observation. AChE activity was then 60--80% of the initial value.
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism; D000287:Administration, Topical; D000818:Animals; D001921:Brain / Q000201:enzymology; D002709:Chlorfenvinphos / Q000008:administration & dosage*; D002800:Cholinesterase Inhibitors; D004456:Echothiophate Iodide / Q000008:administration & dosage*; D004912:Erythrocytes / Q000201:enzymology; D005260:Female; D007306:Insecticides / Q000008:administration & dosage*; D007441:Intubation, Gastrointestinal; D008099:Liver / Q000201:enzymology; D009132:Muscles / Q000201:enzymology; D051381:Rats
chemical_list: D002800:Cholinesterase Inhibitors; D007306:Insecticides; D004456:Echothiophate Iodide; D000110:Acetylcholinesterase; D002709:Chlorfenvinphos