[Prophylaxis of consumption coagulopathy in shock. Dependence of the effect of heparin on the activity of antithrombin III (author's transl)].
In 16 patients admitted in shock, heparin prophylaxis for DIC was carried out. The effect of heparin was monitored by a series of coagulation tests. A distinct relation was found between the effect of heparin on the aPTT and on the thrombin clotting time and the activity of antithrombin III. Even a comparatively slight diminution of this activity resulted in a considerable decrease of the heparin effect on coagulation. Since this effect is of primary importance for the efficacy of prophylaxis of DIC, regular assays of antithrombin III are proposed in shock patients receiving heparin.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000502:physiology*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D006493:Heparin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012769:Shock / Q000150:complications
D000990:Antithrombin III; D006493:Heparin
Heparinprophylaxe der Verbrauchskoagulopathie bei Schockpatienten Abhänggigkeit der Wirkung von der verfüghjaren Antithrombin III-Aktivität.