Acute inhalation toxicity of diiodotetrafluoroethane.
Acute inhalation toxicity studies with diiodotetrafluoroethane in rats following an exposure of 4 h to concentrations of 6-197.5 ppm show that 16.5 ppm to 197.5 ppm impaired dose-related the animals' attitude and posture, motoricity, autonomic reactions and respiratory function. At concentrations of more than about 90 ppm death occurred as a result of cardiac and circulatory failure. On the basis of these results it could be demonstrated that the no-effect level is 6 ppm and the approximate mean lethal concentration (LC50) would be 75 ppm.
D000208:Acute Disease; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006846:Hydrocarbons, Halogenated / Q000633:toxicity*; D009043:Motor Activity / Q000187:drug effects; D051381:Rats
D006846:Hydrocarbons, Halogenated; C027560:diiodotetrafluoroethane