The anti-inflammatory activity of marine natural products--6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate.
Three novel marine substances, 6-n-tridecylsalicylic acid, flexibilide and dendalone 3-hydroxybutyrate, isolated from a brown alga, a soft coral and a dictyoceratid sponge respectively, were active after oral administration in both acute and chronic animal models of inflammation. 6-n-Tridecylsalicylic acid has similar anti-inflammatory activity but less ulcerogenic activity on a molar basis than salicylic acid. The structure and activity of flexibilide did not resemble any known anti-inflammatory substance. Dendalone 3-hydroxybutyrate was a potent inhibitor of prostaglandin synthetase activity and platelet aggregation in vitro.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000009:adverse effects / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000188:drug therapy; D006718:Homosteroids / Q000494:pharmacology*; D007213:Indomethacin / Q000494:pharmacology; D007783:Lactones / Q000494:pharmacology*; D008297:Male; D008386:Marine Biology; D010653:Phenylbutazone / Q000494:pharmacology; D010974:Platelet Aggregation / Q000187:drug effects; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D012459:Salicylates / Q000494:pharmacology*
D000893:Anti-Inflammatory Agents; D006718:Homosteroids; D007783:Lactones; D011453:Prostaglandins; D012459:Salicylates; C027471:6-n-tridecylsalicylic acid; C027469:flexibilide; C027470:dendalone 3-hydroxybutyrate; D010653:Phenylbutazone; D007213:Indomethacin