[Relationship between the chief histocompatibility systems of mice and humans and predisposition to develop narcotic dependence].
Experiments on congenitally resistant lines of mice have demonstrated the relationship between H-2 haplotype and pronounced physical dependence in chronic morphine administration. Distribution of HLA-antigens was studied in a group of polynarcomanic patients who showed a significant increase in the occurrence of HLA-B5- and HLA-CW4-antigens. Potential use of these antigens as genetic markers of predisposition to narcotization is discussed.
D000818:Animals; D004198:Disease Susceptibility; D004351:Drug Resistance; D005838:Genotype; D006680:HLA Antigens / Q000032:analysis; D006649:Histocompatibility Antigens / Q000032:analysis*; D006801:Humans; D008297:Male; D051379:Mice; D008805:Mice, Inbred A; D008809:Mice, Inbred C3H; D009021:Morphine Dependence / Q000235:genetics; D013045:Species Specificity; D013375:Substance Withdrawal Syndrome / Q000235:genetics; D019966:Substance-Related Disorders / Q000235:genetics*
D006680:HLA Antigens; D006649:Histocompatibility Antigens
Sviaz' glavnoĭ sistemy gistosovmestimosti myshi i cheloveka s predraspolozhennost'iu organizma k razvitiiu narkoticheskoĭ zavisimosti.