Jaundice associated with naproxen.
Hepatic injury in association with naproxen therapy is described and documented by liver biopsy in one patient. Histological findings were consistent with a drug-induced hepatitis, and cessation of therapy led to reversal of the clinical and biochemical changes. Circumstantial evidence is in favour of a hypersensitivity response to the drug rather than direct hepatotoxicity. Increased awareness of clinicians of this probably rare side effect of naproxen may help prompt identification of similar cases.
D000368:Aged; D006801:Humans; D007565:Jaundice / Q000139:chemically induced* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D009288:Naproxen / Q000009:adverse effects*
D009288:Naproxen