First-pass effect and intrinsic clearance of propranolol and pindolol in the isolated perfused rat liver.
This study investigated the first-pass effect (E) and total hepatic intrinsic clearance (Clint) of propranolol and pindolol by means of an isolated rat liver perfusion model. It was shown that propranolol has a highly significantly greater E and Clint than pindolol. These marked differences between the drugs may be accounted for by the strong initial binding of propranolol to liver sites, a phenomenon possibly related to the greater lipid solubility of propranolol compared with pindolol.
D000818:Animals; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D010477:Perfusion; D010869:Pindolol / Q000378:metabolism*; D011433:Propranolol / Q000378:metabolism*; D051381:Rats
D011433:Propranolol; D010869:Pindolol