Use of probenecid in ticarcillin-induced hypokalemia.
Probenecid has been suggested as a prophylactic treatment of penicillin-induced hypokalemia, the proposed mechanism being that penicillin will be prevented from acting as a nonreabsorbable anion binding potassium and resulting in increased urinary losses. A rapidly occurring hypokalemia, unresponsive to intravenous replacement of potassium, can be explained by redistribution rather than urinary wastage. We report a case where probenecid was administered for ticarcillin-induced hypokalemia without any significant benefits.
D002648:Child; D006801:Humans; D007008:Hypokalemia / Q000139:chemically induced / Q000188:drug therapy*; D008297:Male; D010406:Penicillins / Q000009:adverse effects*; D011339:Probenecid / Q000627:therapeutic use*; D013982:Ticarcillin / Q000009:adverse effects*
D010406:Penicillins; D013982:Ticarcillin; D011339:Probenecid