title: Cryosurgery in the treatment of lichen sclerosus et atrophicus of the vulva.
abstract: Twelve patients with lichen sclerosus et atrophicus of the vulva were treated by a nitrous oxide cryoprobe. All had had severe itching which was relieved in the post-operative period in 75% and for 3 years in 50%. Eight had histologically proven leukoplakia which cleared post-operatively in five (62.5%) and remained clear at three years in four (50%). In one patient pruritus, leukoplakia and ultimately squamous carcinoma appeared.
mesh_terms: D000368:Aged; D003452:Cryosurgery; D005260:Female; D006801:Humans; D007971:Leukoplakia / Q000209:etiology / Q000601:surgery; D008875:Middle Aged; D012871:Skin Diseases / Q000150:complications / Q000601:surgery*; D012878:Skin Neoplasms / Q000209:etiology / Q000601:surgery; D014845:Vulvar Diseases / Q000150:complications / Q000601:surgery*; D014846:Vulvar Neoplasms / Q000209:etiology / Q000601:surgery