Excretion of salicylic acid into tears following oral administration of aspirin.
The concentration of salicylic acid in human tears has been measured by using reverse-phase, high-pressure liquid chromatography. Pharmacokinetic profiles in tears and in plasma have been obtained following oral administration of 650, 1300, and 1950 mg of aspirin in normal subjects. Salicylate excretion in tears is dose-dependent and is proportional to the plasma concentration. Tear and plasma salicylate levels for rheumatology patients on salicylates are also included.
D000284:Administration, Oral; D000328:Adult; D001172:Arthritis, Rheumatoid / Q000188:drug therapy* / Q000503:physiopathology; D001241:Aspirin / Q000008:administration & dosage* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D012459:Salicylates / Q000032:analysis* / Q000378:metabolism; D013666:Tears / Q000032:analysis* / Q000378:metabolism
D012459:Salicylates; D001241:Aspirin