Synthesis and analgesic activity of N-substituted 6,7-benzomorphans.
Some new N-substituted 6,7-benzomorphans were prepared and tested for analgetic activity. The compounds (I) and (II), which proved the most active in a preliminary screening, were submitted to a more detailed investigation, and their ED50 was determined in mice by the phenylquinone, hot-plate and tail-pinch tests. Studies of acute toxicity and physical dependence capacity were also performed.
D000700:Analgesics / Q000138:chemical synthesis* / Q000633:toxicity; D000818:Animals; D001575:Benzomorphans / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D055598:Chemical Phenomena; D002621:Chemistry; D007928:Lethal Dose 50; D051379:Mice; D009019:Morphinans / Q000138:chemical synthesis*
D000700:Analgesics; D001575:Benzomorphans; D009019:Morphinans