[Synthesis of p-aminobenzenesulfonyldiazine].
New sulfones were synthesized; these are analogues of bis-(4-aminophenyl)sulfone (DDS) but contain, instead of one benzene nucleus, a heterocycle that is a pyrimidine, pyrazine or pyridazine nucleus. This was substituted with amine, methoxy, methyl groups or halogens in order to obtain long-acting drugs, similarly to those obtained in the field of sulfonamides. The synthesis was accomplished by reaction of sodium p-amino- or p-acetamidobenzensulfinate with the corresponding halodiazine; only the p-aminophenyl 3-aminopyridazin-6-yl sulfone was obtained by acid hydrolysis. The compounds showed good antitubercular activity in vitro.
D000995:Antitubercular Agents / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests; D009161:Mycobacterium / Q000187:drug effects; D011719:Pyrazines / Q000138:chemical synthesis / Q000494:pharmacology; D011724:Pyridazines / Q000138:chemical synthesis / Q000494:pharmacology; D011743:Pyrimidines / Q000138:chemical synthesis / Q000494:pharmacology; D013450:Sulfones / Q000138:chemical synthesis* / Q000494:pharmacology
D000995:Antitubercular Agents; D011719:Pyrazines; D011724:Pyridazines; D011743:Pyrimidines; D013450:Sulfones
Sintesi di p-amminobenzensolfonildiazine.