Effect of hyperthermia on experimental bladder tumors.
Studies were made on hyperthermic treatment of BC-50 bladder cancer cells in ACI/N rats with the following results: (1) Hyperthermia had a marked cytotoxic effect on BC-50 transitional carcinoma cells in vitro. (2) In vivo, heat treatment for 30 min was insufficient, but heat treatment for 60 min or more was effective. (3) A significant difference was found between the effects of heat treatment at 41 and 42 degrees C, indicating that the critical temperature for killing tumor cells was 42 degrees C. (4) BC-50 tumor itself was sensitive to the X-ray irradiation so that we could not evaluate the effect of combination treatment of hyperthermia and X-ray irradiation. (5) Hyperthermia in combination with X-ray irradiation prolonged the survival rate of the rats.
D000818:Animals; D002295:Carcinoma, Transitional Cell / Q000628:therapy; D002460:Cell Line; D006358:Hot Temperature / Q000627:therapeutic use*; D008297:Male; D009374:Neoplasms, Experimental / Q000628:therapy; D051381:Rats; D011912:Rats, Inbred ACI; D013997:Time Factors; D001749:Urinary Bladder Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000628:therapy*