title: [Oxidation state of membrane phospholipids and activity of the microsomal system of cholesterol hydroxylation in the liver of animals during atherogenesis].
abstract: Content of cholesterol in various tissues of experimental animals /blood plasma, thoracal department of aorta, liver microsomes/ was increased during atherogenesis depending on the level of aorta impairment. In atherogenesis content of both primary and secondary products of lipid peroxidation was also increased in microsomal membranes of rabbit and mini-pig liver tissue; the increase in the rate of microsomal lipid oxidation was accompanied by a decrease in the activity of membrane-bound microsomal 7 alpha-hydroxylase of cholesterol.
mesh_terms: D000818:Animals; D001011:Aorta / Q000032:analysis; D001161:Arteriosclerosis / Q000378:metabolism*; D002682:Chinchilla; D002784:Cholesterol / Q000032:analysis / Q000378:metabolism*; D002790:Cholesterol 7-alpha-Hydroxylase / Q000378:metabolism; D008054:Lipid Peroxides / Q000096:biosynthesis*; D008563:Membrane Lipids / Q000378:metabolism*; D008862:Microsomes, Liver / Q000378:metabolism*; D010084:Oxidation-Reduction; D010743:Phospholipids / Q000378:metabolism*; D011817:Rabbits
chemical_list: D008054:Lipid Peroxides; D008563:Membrane Lipids; D010743:Phospholipids; D002784:Cholesterol; D002790:Cholesterol 7-alpha-Hydroxylase
vernacular_title: Stepen'okislennosti membrannykh fosfolipidov i aktivnost' mikrosomal'noĭ sistemy gidroksilirovaniia kholesterina v pecheni zhivotnykh pri aterogeneze.