A possible role of Z protein in dietary control of hepatic triacylglycerol synthesis.
The effects of fasting and refeeding on hepatic Z protein were investigated in rats. When [U-14C]palmityl-CoA was added to the liver cytosol fraction from fat-free refed rats, more binding of labeled palmityl-CoA to the Z-protein region was found than in the case of fasted rats. Also the radioactivities in specific precipitations of the palmityl-CoA binding protein with anti-Z immunoglobulin G were higher in the refed rats. The Z protein which stimulated diacylglycerol acyltransferase may be involved in the change of triacylglycerol synthesis in fasted and refed rat livers.
D000217:Acyltransferases / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000494:pharmacology*; D051048:Diacylglycerol O-Acyltransferase; D004591:Electrophoresis, Polyacrylamide Gel; D005215:Fasting; D050556:Fatty Acid-Binding Proteins; D007518:Isoantibodies / Q000378:metabolism; D008099:Liver / Q000502:physiology*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D010171:Palmitoyl Coenzyme A / Q000378:metabolism; D051381:Rats; D014280:Triglycerides / Q000096:biosynthesis*
D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins; D007518:Isoantibodies; D014280:Triglycerides; C027456:anti-Z immunoglobulin G; D010171:Palmitoyl Coenzyme A; D000217:Acyltransferases; D051048:Diacylglycerol O-Acyltransferase