Peripheral neuropathy in the spontaneously diabetic BB-Wistar-rat. An ultrastructural study.
Peripheral nerves of the diabetic insulin-dependent BB-Wistar-rat were studied ultrastructurally. Conspicuous early changes consisted of mitochondrial accumulation of glycogen in the axons and the development of honey-combed Schwann cell-axon networks. The later stages of the diabetic syndrome showed axonal dwindling and disintegration in both myelinated and unmyelinated fibers. The present findings are compared with those of other experimental diabetic models.
D000818:Animals; D001369:Axons / Q000648:ultrastructure; D003921:Diabetes Mellitus, Experimental / Q000473:pathology*; D003929:Diabetic Neuropathies / Q000473:pathology*; D006003:Glycogen / Q000032:analysis; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure; D010525:Peripheral Nerves / Q000648:ultrastructure; D051381:Rats; D011919:Rats, Inbred Strains; D012583:Schwann Cells / Q000648:ultrastructure; D013997:Time Factors
D006003:Glycogen