[Acquired coagulation inhibitors. 10 cases (author's transl)].
A circulating anticoagulant with antiprothrombinase activity was detected in 10 patients, 4 of whom had systemic lupus erythematosus. Clinically, haemorrhages occurred only in patients with associated thrombopenia; some developed thrombosis. Recalcification time and activated partial thromboplastin time were prolonged in the patients' plasma and in mixed patients' and control plasma. In 5 cases the anticoagulant was isolated by chromatography as IgG or IgM.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000744:Anemia, Hemolytic, Autoimmune / Q000097:blood; D001777:Blood Coagulation; D002648:Child; D005260:Female; D006487:Hemostasis; D006801:Humans; D006973:Hypertension / Q000097:blood; D007074:Immunoglobulin G / Q000302:isolation & purification; D007075:Immunoglobulin M / Q000302:isolation & purification; D008180:Lupus Erythematosus, Systemic / Q000097:blood; D008297:Male; D008875:Middle Aged
D007074:Immunoglobulin G; D007075:Immunoglobulin M
Inhibiteurs acquis de la coagulation. 10 observations.