[Comparative study of the intermittent and continuous action of the herbicide, Ramrod].
Repeated oral toxicity was assayed in albino rats of either sex, receiving every day 70 mg/kg of Ramrod for 4 months (group I) and everyday, but on alternate weeks-140 mg/kg (group II). A third experimental group of animals received daily 70 mg/kg of Ramrod on alternate weeks for 8 months. In comparison with the respective pure control groups of rats, those receiving monotonous treatment has the most liver function changes. Both intermittent schedules induced a phasic pattern in the adjustment processes: the response to intermittent administration of 70 mg/kg Ramrod was that of physiologic compensation. Periodic application of the herbicide for plant protection should be preferred, in view of prevention from progessional poisoning.
D000083:Acetanilides / Q000008:administration & dosage / Q000633:toxicity*; D000284:Administration, Oral; D000818:Animals; D001769:Blood / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D006321:Heart / Q000187:drug effects; D006540:Herbicides / Q000008:administration & dosage / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051381:Rats; D013997:Time Factors
D000083:Acetanilides; D006540:Herbicides; C011088:propachlor
Sravnitelno izsledvane na intermitentnoto i monotonnoto deĭstvie na kherbitsid ramrod.