[The cardiovascular effect of diisopropylaminhydrochloride (Disotat) in non-pregnant hypertensive women].
With the help of the quantitative sphygmometry and the unbloody graphic registration of the arterial pressure the hemodynamic effect of diisopropylamine hydrochloride (disotat) was investigated in 10 non-pregnant hypertensive patients. After a rapid intravenous application of 100 mg diisopropylamine hydrochloride (DIIPA) within 10 minutes after injection a statistically significant decrease of the systolic pressure by 15%, of the diastolic pressure by 9% and of the arterial medium pressure by 15% developed. Thus the blood pressure amplitude was restricted by 25%. Connected with the decrease of the pressure was a significant decrease of the stroke volume by 22% and of the cardiac output by 19%. The total peripheral resistance increased statistically uncharacteristically by 13% in comparison to the initial value. The courses of the curves show that in all parameters during the 45-minute observation duration the initial values are striven for, however, without reaching them in every case. Thus the decrease of pressure induced by bolus injection of DIIPA independent on the existence of pregnancy is always accompanied by a decrease of the output volumes of the heart and the increase of the total peripheral resistance.
D000328:Adult; D001794:Blood Pressure / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D011247:Pregnancy; D011437:Propylamines / Q000494:pharmacology / Q000627:therapeutic use*; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects
D011437:Propylamines; C007442:diisopropylamine
Die kardiovaskuläre Wirksamkeit von Diisopropylaminhydrochlorid (Disotat) bei nichtschwangeren Hypertonikerinnen.