Effects of hydroxyurea on postnatal growth and behaviour of rats.
Hydroxyurea was administered intraperitoneally to pregnant albino rats in a single dose of 2000 mg/kg on day 14 of gestation. Both the perinatal and postnatal mortality rates of the progeny were increased and their weight gain reduced. Exploratory locomotion of 32-day-old rats, calculated by means of an 'activity index', was significantly reduced. The treatment had no effect on the brain weight. The fertility of the progeny was not impaired.
D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development*; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000254:growth & development; D005260:Female; D005298:Fertility / Q000187:drug effects; D005333:Fetus / Q000187:drug effects*; D006918:Hydroxyurea / Q000633:toxicity*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats
D006918:Hydroxyurea