[In vitro and in vivo antibacterial activity of cephapirin-dicloxacillin combination in the ratio 1:1].
Studies were carried out on the combination, 1:1 ratio, of two antibiotics: cephapirin and dicloxacillin. After the analysis of the activity spectrum "in vitro" of each antibiotics, the synergism of this combination against the Gram-negative bacteria strains was clearly demonstrated. This combination demonstrated a particular activity against the beta-lactamases producing strains "in vitro" as well in protection tests "in vivo" in experimental infections in mice.
D000818:Animals; D001419:Bacteria / Q000187:drug effects*; D002511:Cephalosporins / Q000494:pharmacology*; D002514:Cephapirin / Q000494:pharmacology*; D004009:Dicloxacillin / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D051379:Mice
D002511:Cephalosporins; D002514:Cephapirin; D004009:Dicloxacillin
Attivta' antibetterica "in vivo dell'associazione cefapi-rine - dicloxacillina in rapporto 1:1.