Thermostability and aliphatic index of globular proteins.
A statistical analysis shows that the aliphatic index, which is defined as the relative volume of a protein occupied by aliphatic side chains (alanine, valine, isoleucine, and leucine), of proteins of thermophilic bacteria is significantly higher than that of ordinary proteins. The index may be regarded as a positive factor for the increase of thermostability of globular proteins.
D000409:Alanine / Q000032:analysis*; D001426:Bacterial Proteins / Q000032:analysis*; D055598:Chemical Phenomena; D002621:Chemistry; D004355:Drug Stability; D001411:Geobacillus stearothermophilus / Q000201:enzymology; D006358:Hot Temperature; D007532:Isoleucine / Q000032:analysis*; D007930:Leucine / Q000032:analysis*; D013223:Statistics as Topic; D014633:Valine / Q000032:analysis*
D001426:Bacterial Proteins; D007532:Isoleucine; D007930:Leucine; D014633:Valine; D000409:Alanine