[Isolation and biological properties of rat embryo cells transformed by the DNA of bovine adenovirus type 3 (BA-3)].
Cloned cultures of rat embryo cells transformed by BA-3 DNA and those transformed by the virus in hamsters were obtained. It was found that these cultures contain T-antigen and do not differ in oncogenicity for hosts. The adenovirus type 5 DNA transformed cells of the same primary culture of rat embryo fibroblasts produced no tumors in syngeneic newborn rats. The role of the viral genome in oncogenicity of the cells transformed by it is discussed.
D000256:Adenoviridae / Q000472:pathogenicity*; D000818:Animals; D002460:Cell Line; D002469:Cell Separation; D002472:Cell Transformation, Viral / Q000187:drug effects*; D002478:Cells, Cultured; D006224:Cricetinae; D004279:DNA, Viral / Q000494:pharmacology*; D004622:Embryo, Mammalian / Q000187:drug effects*; D008647:Mesocricetus; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology; D051381:Rats; D011919:Rats, Inbred Strains
D004279:DNA, Viral
Poluchenie i biologiheskie svoĭstva kletok émbriona krysy, transformirovannykh DNK bych'ego adenovirusa tipa 3 (BA-3).