title: Renal papillary necrosis in thyroid carcinoma.
abstract: A thirty-four-year-old man with progressive visual impairment was found to have thyromegaly and renal insufficiency at the time of admission. Subsequent evaluation demonstrated bilateral optic neuritis and a thyroid nodule which proved to be a follicular carcinoma. Nephrologic studies revealed bilateral papillary necrosis and chronic interstitial nephritis on biopsy. The patient's renal function stabilized and twenty-four-hour protein excretion diminished after hemithyroidectomy. Carcinoma-related protein production may have played a role in the development of the observed renal lesions. Carcinoma should be a consideration in patients with unexplained papillary necrosis.
mesh_terms: D000230:Adenocarcinoma / Q000150:complications*; D000328:Adult; D006801:Humans; D007681:Kidney Papillary Necrosis / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D009363:Neoplasm Proteins / Q000096:biosynthesis; D009902:Optic Neuritis / Q000150:complications; D011859:Radiography; D013964:Thyroid Neoplasms / Q000150:complications*; D014792:Visual Acuity
chemical_list: D009363:Neoplasm Proteins