title: "Diclonal" gammopathies.
abstract: Eleven patients with "diclonal" gammopathies have been followed clinically and cytologically in relation to the changes in their serum protein composition. It was observed that the malignant transformation became faster after a second protein had appeared with the appearance of immature lymphoid elements and plasmoblasts. Malignant transformation may occur after long periods of stagnation, therefore a continuous observation of such cases is mandatory.
mesh_terms: D000368:Aged; D001853:Bone Marrow / Q000648:ultrastructure; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000150:complications
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M