The persistence of the effect of methylglucamine orotate on the retention of a learned behavior in the rat.
The effects of methylglucamine orotate (MGO) on the retention of a brightness discrimination in rats was investigated after different intervals between treatment and acquisition, 225 mg MGO/kg were injected intraperitoneally each day over a period of 10 days. Control animals received a NaCl-solution. After drug-free intervals of 5 days or 12 days respectively, MGO-treated rats showed significantly better retention of the learned reaction than controls, whereas their training performance was not influenced. Possible interpretations of the long-lasting persistence of the orotate effect are discussed.
D000818:Animals; D004193:Discrimination Learning / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D008536:Meglumine / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D008568:Memory / Q000187:drug effects*; D009963:Orotic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D012153:Retention, Psychology / Q000187:drug effects*
C022100:methylglucamine orotate; D009963:Orotic Acid; D008536:Meglumine