Occurrence of adult Fanconi syndrome in benign monoclonal gammopathy.
Adult Fanconi syndrome has been described as a manifestation of a latent form of myeloma. Since benign monoclonal gammopathy (BMG) is a latent form of myeloma we studied ten patients with this disease with respect to the adult Fanconi syndrome. These patients were selected from a larger group with BMG because of urinary excretion of monoclonal light chains. In no instance could a complete Fanconi syndrome be shown, but one patient, who also had a diabetic nephropathy, had very high levels of urinary beta 2-microglobulins. Two additional patients showed minor features included in the adult Fanconi syndrome. BMG does not seem to be associated with an increased risk of developing adult Fanconi syndrome.
D000368:Aged; D003928:Diabetic Nephropathies / Q000150:complications / Q000652:urine; D005198:Fanconi Syndrome / Q000150:complications*; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000652:urine; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000150:complications
D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M