title: Urinary prostaglandins E2 and F2 alpha in healthy newborns, infants, children, and adults.
abstract: Radioimmunoassay with specific antibodies from the Pasteur Institute was used for urinary PGE2 and PGF2 alpha determination in 51 individuals 5 healthy newborn, 9 infants, 15 children and 22 adults. PGE2 excretion rose significantly with increasing age from 15,2 +/- 2,3 pmols/24 h in the newborn up to 940,6 +/- 101,7 pmols/24 h in adults; an even more pronounced increase of PGF2 alpha with age was observed. In infants the ratio PGE2/PGF2 alpha was higher (0,49) than in the children (0,22) but in adults it increased and reached a level of 0,67. In the latter group urinary excretion of Pgs was higher in males than in females but the ratio PGE2/PGF2 alpha was the same in both sexes.
mesh_terms: D000328:Adult; D000375:Aging; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000652:urine; D011458:Prostaglandins E / Q000652:urine*; D011460:Prostaglandins F / Q000652:urine*; D011863:Radioimmunoassay; D012737:Sex Factors; D012964:Sodium / Q000652:urine
chemical_list: D011458:Prostaglandins E; D011460:Prostaglandins F; D012964:Sodium; D003404:Creatinine; D011188:Potassium