Enhancement of pulmonary metastases following the intravenous infusion of a suspension of ellagic acid in traumatized rats.
A significant shortening of the silicone and glass clotting times and a reduction of oozing from the exposed femoral veins was observed following the infusion of EA. Ellagic acid significantly enhanced metastases formation; and in traumatized animals its effect was more pronounced. No definite explanation on the combined effect of trauma and EA can be offered at this time; however several possibilities are discussed. There was no obvious untoward side effect of EA in any of the animals studied.
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects; D002279:Carcinoma 256, Walker / Q000473:pathology; D004610:Ellagic Acid / Q000494:pharmacology*; D005260:Female; D007263:Infusions, Parenteral; D008175:Lung Neoplasms / Q000556:secondary*; D051381:Rats; D013997:Time Factors; D014947:Wounds and Injuries / Q000150:complications / Q000503:physiopathology*
D001578:Benzopyrans; D004610:Ellagic Acid