Metabolites of the aminoacetone pathway in blood after exercise.
The following article reports (A) data on glyoxalase I activity in skeletal muscle of untrained men and endurance--trained athletes, and (B) the presence at rest and the rise in blood after exercise of two metabolites of the aminoacetone pathway of amino acid degradation in man. Glyoxalase I showed an average activity of 191 +/- 38 U/g wet weight (37 degrees C) in bioptic samples of m.vastus medialis quadricipitis of young adults whereas this was of 235 +/- 64 U/g (p < 0.15) in athletes. After an ergometer exercise test with increasing intensity (50 to 400 Watt (W), 3 min-steps) by well trained cyclists, blood (L-(+)-lactate increased to 10.12 mmole/liter, whereas methylglyoxal rose by 48.4% and D-(-)-lactate by 70% (resting levels 92 and 100/mumole/liter, respectively). The possible physiologic significance of the assumed aminoacetone pathway was discussed with respect to muscular activity.
D000096:Acetone / Q000031:analogs & derivatives* / Q000378:metabolism; D000596:Amino Acids / Q000378:metabolism*; D006801:Humans; D007773:Lactates / Q000097:blood; D007791:Lactoylglutathione Lyase / Q000378:metabolism*; D008190:Lyases / Q000378:metabolism*; D008297:Male; D009132:Muscles / Q000201:enzymology; D005082:Physical Exertion; D011765:Pyruvaldehyde / Q000097:blood; D013237:Stereoisomerism
D000596:Amino Acids; D007773:Lactates; D000096:Acetone; D011765:Pyruvaldehyde; D008190:Lyases; D007791:Lactoylglutathione Lyase; C006495:aminoacetone