Facilitation of avoidance behavior by chlordiazepoxide and chlordiazepoxide-amphetamine combination: effect on performance.
Chlordiazepoxide, 5 mg/kg, given at various stages of training invariably facilitated the shuttle box avoidance of CD-1 mice for a short period of time (100 trials); no after-effects were observed on the following daily session. Amphetamine, 1 mg/kg, usually did not facilitate significantly the responding, but its combination with chlordiazepoxide produced a stronger and more pronounced effect than that of chlordiazepoxide alone. In prolonged (600-trial) sessions the performance of mice declined in the second half of the session; this decline was temporarily reversed by chlordiazepoxide given alone or with amphetamine after the first 300 trials. The results indicate that the facilitation of shuttle-box avoidance behavior by chlordiazepoxide or chlordiazepoxide-amphetamine combination is due to the improvement of performance.
D000661:Amphetamine / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D002707:Chlordiazepoxide / Q000008:administration & dosage / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D051379:Mice
D002707:Chlordiazepoxide; D000661:Amphetamine