[Lecithin-cholesterol acyltransferase activity and lipid composition of high density lipoprotein subfractions in hyperalphalipoproteinemia].
In blood plasma of men activity of lecithin-cholesterol acyl transferase /LCAT/ was elevated when the cholesterol concentration was increased in the fraction of high density lipoproteins /HDL/; the enzymatic activity was evaluated by the rate of 3H-cholesterol esterification in endogenous HDL. The phenomenon observed was accompanied by an increase in content of HDL2 subfraction: The content of free cholesterol was found to increase in the HDL2 fraction obtained from persons with hyper-alpha-lipoproteinemia. Analysis of the data obtained showed that LCAT activity was preferentially dependent on HDL3 cholesterol concentration in persons with low and middle content of HDL cholesterol, and--on HDL2 cholesterol concentration in patients with hyper-alpha-lipoproteinemia.
D000328:Adult; D055598:Chemical Phenomena; D002621:Chemistry; D002784:Cholesterol / Q000097:blood; D002788:Cholesterol Esters / Q000097:blood; D006801:Humans; D006951:Hyperlipoproteinemias / Q000097:blood* / Q000201:enzymology; D008075:Lipoproteins, HDL / Q000097:blood; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000097:blood*
D002788:Cholesterol Esters; D008075:Lipoproteins, HDL; D002784:Cholesterol; D007862:Phosphatidylcholine-Sterol O-Acyltransferase
Aktivnost' letsitin-kholesterin-atsiltransferazy i lipidnyĭ sostav podfraktsiĭ lipoproteidov vysokoĭ plotnosti pri giperal'falipoproteidemii.