Proteolytic activation of the haemagglutinin-neuraminidase of Newcastle disease virus involves loss of a glycopeptide.
The uncleaved (HN0) and the cleaved (HN) forms of the haemagglutinin-neuraminidase glycoprotein of Newcastle disease virus (NDV), strain Ulster, were analysed by polyacrylamide gel electrophoresis under reducing and non-reducing conditions. When HN0 is converted into HN, a glycopeptide with an apparent mol. wt. of about 8000, which is not found in the mature spike, is removed.
D006020:Glycopeptides / Q000378:metabolism*; D006023:Glycoproteins / Q000032:analysis / Q000378:metabolism; D006389:Hemagglutinins, Viral; D009439:Neuraminidase / Q000032:analysis / Q000378:metabolism*; D009522:Newcastle disease virus / Q000032:analysis / Q000378:metabolism*; D014764:Viral Proteins / Q000032:analysis / Q000378:metabolism*
D006020:Glycopeptides; D006023:Glycoproteins; D006389:Hemagglutinins, Viral; D014764:Viral Proteins; D009439:Neuraminidase