Mucin-like changes in keloids.
Six of 125 keloids of the earlobe demonstrated a peculiar accumulation of mucinous material within their stroma. The six patients had all received prior injections of a corticosteroid compound. The histopathologic picture is characterized by irregularly contoured pools of amorphous eosinophilic material surrounded by a variable granulomatous response of multinucleate giant cells and bubbly histiocytes. Histochemical studies demonstrated that the material is different from the hyaluronic acid-rich substances of the usual forms of cutaneous mucinoses. The lesion is similar to but distinct from that previously described to occur in nasal mucosa injected with corticosteroids. Its recognition and correlation with clinical history should prevent confusion with other entities.
D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000009:adverse effects; D000328:Adult; D002648:Child; D005260:Female; D006801:Humans; D007627:Keloid / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D008297:Male; D009077:Mucins / Q000378:metabolism*
D000305:Adrenal Cortex Hormones; D009077:Mucins