Chlamydia psittaci infection in lines of mice with high or low antibody responses.
Biozzi's high (H) and low (L) antibody producer mice were i.v. infected with a suspension containing 10(4)/ml viable C. psittaci organisms. H mice humoral anti-Chlamydia response was much higher than that of L mice. L mice natural resistance to infection with live Chlamydia was higher than that of H mice. Since the two lines exhibit inverse differences in B-cell and macrophage functions, but they are quite similar with regard to T-cell-mediated immunity, it would appear that macrophages play a more important and earlier role than humoral antibodies in resistance to chlamydial infection in H and L mice.
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis*; D002691:Chlamydophila psittaci / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D008297:Male; D051379:Mice / Q000235:genetics*; D009956:Psittacosis / Q000276:immunology*; D013154:Spleen / Q000276:immunology
D000907:Antibodies, Bacterial