Decreased adenosine deaminase activity in peripheral lymphocytes from tumor patients with metastasis.
We determined the levels of adenosine deaminase (ADA) activity in peripheral lymphocytes of 22 tumor patients: 54% had metastasis; 59% were undergoing chemotherapy at the time of the study. The mean ADA value of all patients was significantly lower than that of 15 healthy subjects of a similar age. When the patients were allocated by treatment and metastasis, the decrease of ADA activity appeared to be associated to the presence of metastasis.
D000243:Adenosine Deaminase / Q000378:metabolism*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000201:enzymology*; D009700:Nucleoside Deaminases / Q000378:metabolism*
D009700:Nucleoside Deaminases; D000243:Adenosine Deaminase