Somatic-cell hybrids producing antibodies against CEA.
Monoclonal antibodies to carcinoembryonic antigen (CEA) promise improved specificity for the measurement of this widely expressed human cancer antigen. A mouse monoclonal antibody binds weakly to CEA in perchloric acid extracts of tumour but strongly to CEA similarly isolated from serum, and its spectrum of cancer detection differs from conventional antisera.
D000818:Animals; D000912:Antibodies, Neoplasm / Q000096:biosynthesis* / Q000276:immunology; D000915:Antibody Affinity; D000918:Antibody Specificity; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D002846:Chromatography, Affinity; D006801:Humans; D006822:Hybrid Cells; D008113:Liver Neoplasms / Q000276:immunology / Q000556:secondary; D051379:Mice; D008807:Mice, Inbred BALB C; D011863:Radioimmunoassay
D000912:Antibodies, Neoplasm; D002272:Carcinoembryonic Antigen