Biotransformation of allylbenzene analogues in vivo and in vitro through the epoxide-diol pathway.
1. The epoxidation of allylbenzene, safrole, estragole, eugenol and eugenol methyl ether was investigated in rats pretreated with these compounds and also in vitro using hepatic microsomal preparations and adult rat liver cell cultures. 2. Dihydrodiols were detected in the urine and liver of rats pretreated with allylbenzene compounds. Similarly, incubation of allylbenzene epoxides with hepatic microsomal preparations and adult rat liver cell cultures gave rise to the formation of dihydrodiols.
D000081248:Allylbenzene Derivatives; D000818:Animals; D000840:Anisoles / Q000378:metabolism; D001711:Biotransformation; D004852:Epoxy Compounds / Q000378:metabolism*; D004988:Ethers, Cyclic / Q000378:metabolism*; D005054:Eugenol / Q000378:metabolism; D008401:Gas Chromatography-Mass Spectrometry; D006018:Glycols / Q000378:metabolism*; D066298:In Vitro Techniques; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012451:Safrole / Q000378:metabolism
D000081248:Allylbenzene Derivatives; D000840:Anisoles; D004852:Epoxy Compounds; D004988:Ethers, Cyclic; D006018:Glycols; D005054:Eugenol; C007633:estragole; D012451:Safrole