Dopamine depletion by 6-hydroxydopamine prevents conditioned taste aversion induced by methylamphetamine but not lithium chloride.
Specific lesions of the central dopaminergic system produced by intraventricular injections of 6-hydroxydopamine with pargyline and desmethylimipramine pretreatment significantly attenuated conditioned taste aversions to a sweetened-condensed milk solution induced by methylamphetamine. Identically treated rats formed an aversion to the milk solution when lithium chloride was utilized. These results suggest that the methylamphetamine-induced aversion is dependent upon intact dopaminergic neurons.
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism / Q000502:physiology*; D004327:Drinking Behavior / Q000187:drug effects; D006892:Hydroxydopamines / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D013649:Taste
D006892:Hydroxydopamines; D008694:Methamphetamine; D008094:Lithium; D004298:Dopamine; D009638:Norepinephrine