Chronic hemolytic anemia due to a monoclonal IgG cold agglutinin with anti-Pr specificity.
Immunologic studies performed in a case of autoimmune chronic hemolytic anemia with low titer cold agglutinins (1/16) demonstrated that the cold agglutinins corresponded to monoclonal IgG with anti-Pr specificity. This antibody had a large thermal amplitude, being active at 37 degrees C. These unusual characteristics may define a distinct subset of chronic cold agglutinin disease.
D000328:Adult; D000373:Agglutinins; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D000918:Antibody Specificity; D001323:Autoantibodies; D001789:Blood Group Antigens; D002908:Chronic Disease; D002999:Clone Cells / Q000276:immunology; D003080:Cold Temperature; D005260:Female; D006801:Humans; D007122:Immunoelectrophoresis; D007074:Immunoglobulin G
D000373:Agglutinins; D001323:Autoantibodies; D001789:Blood Group Antigens; D007074:Immunoglobulin G