Ferromagnetic embolization. Experimental evaluation.
Flow of embolized carbonyl iron particles under the influence of a magnetic field was evaluated in vitro and in vivo. The magnetic force caused particles to form aggregates, obstructing tubing or vascular beds. In dogs, 0.5 cc of iron particles injectged into a renal artery under magnetic control caused total occlusion and necrosis; injection without magnetic control caused little damage and no change in function. There was little systemic toxicity. Injection of iron particles under magnetic control may be helpful in embolic arterial occlusion and localized irradiation, hyperthermia, and chemotherapy.
D000818:Animals; D003973:Diatrizoate; D004285:Dogs; D004621:Embolization, Therapeutic / Q000379:methods*; D066298:In Vitro Techniques; D007501:Iron; D054354:Iron Carbonyl Compounds; D007668:Kidney / Q000033:anatomy & histology / Q000000981:diagnostic imaging; D007674:Kidney Diseases / Q000628:therapy; D008280:Magnetics; D008954:Models, Biological; D009942:Organometallic Compounds; D011817:Rabbits; D011859:Radiography; D012077:Renal Artery
D009942:Organometallic Compounds; D003973:Diatrizoate; D054354:Iron Carbonyl Compounds; D007501:Iron