Effects of chlordiazepoxide-morphine combinations on spontaneous locomotor activity in three inbred strains of mice.
Spontaneous locomotor activity has been studied, in three strains of mice, following the administration of morphine and chlordiazepoxide, given alone or in combination. The results demonstrate that chlordiazepoxide enhances the morphine-induced locomotor stimulation in C57/BL/6 and BALB/c mice and counteracts the depressant effect exerted by morphine in DBA/2 mice.
D000818:Animals; D002707:Chlordiazepoxide / Q000494:pharmacology*; D004347:Drug Interactions; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects*; D013045:Species Specificity; D013268:Stimulation, Chemical
D002707:Chlordiazepoxide; D009020:Morphine