Failure of prostaglandin inhibition to attenuate the tolerance to hemorrhage in domestic chicken.
Domestic fowl have been shown to have the ability to withstand severe hemorrhage. Recent studies in mammals have suggested that prostaglandin hormones may be beneficial during hemorrhagic shock. It has been reported that chickens have high circulating levels of prostaglandins. Anesthetized chickens were stressed by the removal of 45% of the their estimated total blood volume. When compared to controls, neither prostaglandin inhibition with indomethacin or meclofenamate decreased the ability of these animals to tolerate hemorrhage. Changes in mean arterial pressure following hemorrhage were not altered by prostaglandin inhibition. These data demonstrate that prostaglandins are not responsible for the tolerance to hemorrhage observed in domestic fowl.
D000818:Animals; D002645:Chickens; D006470:Hemorrhage / Q000378:metabolism / Q000517:prevention & control / Q000662:veterinary*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D008469:Meclofenamic Acid / Q000494:pharmacology; D011201:Poultry Diseases / Q000378:metabolism / Q000517:prevention & control*; D011448:Prostaglandin Antagonists / Q000378:metabolism; D011453:Prostaglandins / Q000627:therapeutic use*
D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D008469:Meclofenamic Acid; D007213:Indomethacin