A new osmium-191 leads to iridium-191m generator.
A new osmium-191 leads to iridium-191m generator suitable for first-pass radionuclide angiocardiography has been developed. This generator system allows repeated elutions of 4.96-sec iridium-191m from its 15.4-day Os- 191 parent. The Os-191 is loaded on an anion-exchange column (AGMP-1) and Ir- 191m eluted with 0.9% NaCl at pH 1. Each elution (0.6 to 1 ml) of the generator yields about 7 to 10% Ir-191m and gives 0.003-0.008% of Os-191 breakthrough. Toxicity studies of the generator eluate carried out in animals support the safety of using iridium-191m in humans. The long shelf-life of the generator (approximately equal to 2 wk) will allow medical centers to use Ir- 191m for routine clinical diagnosis. Iridium-191m obtained by this method should find additional useful applications in nuclear medicine.
D000818:Animals; D001822:Body Burden; D055598:Chemical Phenomena; D002621:Chemistry; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D004285:Dogs; D006321:Heart / Q000000981:diagnostic imaging; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007495:Iridium / Q000633:toxicity; D051379:Mice; D009992:Osmium; D011817:Rabbits; D011868:Radioisotopes; D011876:Radionuclide Generators; D011877:Radionuclide Imaging; D013997:Time Factors; D014018:Tissue Distribution
D011868:Radioisotopes; D009992:Osmium; D007495:Iridium