Loss of gene repression activity: a theory of cellular senescence.
Recent evidence bearing on cellular senescence has come from cell fusion and clonal lifespan studies. To date, no model has been developed that is consistent with the recent findings. The purpose of this paper is to present a mechanism for cell senescence that is qualitatively consistent with the experimental evidence.
D000818:Animals; D002470:Cell Survival; D004794:Enzyme Repression; D005796:Genes; D006801:Humans; D008957:Models, Genetic; D013269:Stochastic Processes