Myocardial imaging in man with I-123 meta-iodobenzylguanidine.
Meta-[123I]iodobenzylguanidine (m-[123I]IBG), a guanethidine analog, was used to image the myocardium in five normal male volunteers. Each subject received 2.0 mCi m-[123I]IBG intravenously. Four were given a bolus injection. Multiple myocardial scintigrams were obtained over a 2-hr period. Myocardial uptake was calculated by dividing the decay-corrected global myocardial count rate (after interpolated background correction) by the peak count rate during the first passage of the m-[123I]IBG bolus through the heart. The left ventricle could be visualized within 1-2 min of m-[123I]IBG injection. Mean myocardial uptake was 0.63% (range 0.45-0.78%) of injected dose at 5 min, and 0.76% (range 0.49-0.93%) at 2 hr (n = 4). m-[123I]IBG may provide quantitative information on myocardial catecholamine content.
D019797:3-Iodobenzylguanidine; D000328:Adult; D002395:Catecholamines / Q000378:metabolism; D004341:Drug Evaluation; D006146:Guanidines / Q000378:metabolism*; D006207:Half-Life; D006321:Heart / Q000000981:diagnostic imaging*; D006352:Heart Ventricles / Q000000981:diagnostic imaging; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D009206:Myocardium / Q000378:metabolism*; D011849:Radioactive Tracers; D011877:Radionuclide Imaging; D012588:Scintillation Counting; D013329:Structure-Activity Relationship; D014018:Tissue Distribution
D002395:Catecholamines; D006146:Guanidines; D007457:Iodine Radioisotopes; D011849:Radioactive Tracers; D019797:3-Iodobenzylguanidine