Enhanced sympathetic activity caused by salt loading in spontaneously hypertensive rats.
1. Salt loading accelerates and increases the rise in blood pressure (spSH) in stroke-prone spontaneously hypertensive rats, but not in Wistar-Kyoto (WK) rats. 2. In both strains a slight increase in plasma volume was obtained during salt loading. 3. Salt loading caused a distinct increase in plasma noradrenaline concentration in spSH rats, but a slight decrease in WK rats. Plasma adrenaline and dopamine concentrations remained unaffected. 4. Exposure to cold resulted in a more marked stimulation of sympathoadrenal and sympathoneuronal activity in salt-loaded spSH rats than in spSH rats on a normal sodium diet. 5. It is concluded that salt loading results in a further increase of the already elevated sympathetic activity in spSH rats.
D000375:Aging; D000818:Animals; D001794:Blood Pressure; D003080:Cold Temperature; D004298:Dopamine / Q000097:blood; D004837:Epinephrine / Q000097:blood; D005260:Female; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D009638:Norepinephrine / Q000097:blood; D010953:Plasma Volume; D051381:Rats; D012964:Sodium / Q000378:metabolism*; D013564:Sympathetic Nervous System / Q000503:physiopathology*
D012964:Sodium; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine