Acute effects of dietary protein on calcium metabolism in patients with osteoporosis.
Five untreated osteoporotic patients were studied in a metabolic unit for 30 days while receiving control (0.8 gm/kg) and high (2.0 gm/kg) protein diets of purified proteins. The high protein diet increased urinary calcium and produced a negative calcium balance without causing significant change in calcium absorption, serum chemical values, or urinary sodium and potassium. Variable effects of calcium and/or estrogens were found on the negative balance. Hence, increased dietary protein acutely causes a negative calcium balance in osteoporotic patients and may contribute to bone loss in this disease.
D002118:Calcium / Q000378:metabolism* / Q000652:urine; D004044:Dietary Proteins / Q000494:pharmacology*; D005260:Female; D006801:Humans; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000378:metabolism*
D004044:Dietary Proteins; D002118:Calcium