Stimulation of adenylate cyclase in rat striatum by pergolide: influence of GTP.
Pergolide stimulates adenylate cyclase activity in homogenates of rat striatum. In contrast, bromocriptine and lisuride are inactive. GTP enhances the stimulation produced by pergolide and has no effect on the other ergots tested. The stimulation produced by pergolide is inhibited by haloperidol but not by molindone. It is concluded that pergolide acts as an agonist at dopaminergic receptors coupled to adenylate cyclase in rat striatum.
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D004873:Ergolines / Q000494:pharmacology*; D006160:Guanosine Triphosphate / Q000502:physiology*; D008297:Male; D010479:Pergolide; D051381:Rats; D011954:Receptors, Dopamine / Q000502:physiology
D004873:Ergolines; D011954:Receptors, Dopamine; D010479:Pergolide; D006160:Guanosine Triphosphate; D000262:Adenylyl Cyclases