[The therapeutic effect of nanaomycin A against experimental Trichophyton mentagrophytes infection in guinea pigs (author's transl)].
Acute toxicity of nanaomycin A was tested in mice and rats. It was found that the antibiotic was well absorbed topically so that topical LD50 was approximately the same as intravenous LD50 in mice. The therapeutic effect of nanaomycin A and siccanin against experimental cutaneous Trichophyton mentagrophytes infection in guinea pigs was investigated. Topically applied formulation of nanaomycin A was very effective in improving the condition of lesions and in preventing fungal growth in the infected tissues. Nanaomycin A and siccanin were comparable in activity in experiments.
D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use* / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D051379:Mice; D009285:Naphthoquinones / Q000008:administration & dosage / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D014005:Tinea / Q000188:drug therapy*; D000095622:Benzoisochromanequinones
D000935:Antifungal Agents; D009285:Naphthoquinones; C008638:nanaomycin A; D000095622:Benzoisochromanequinones