[Effects of indomethacin on rats kept on a normal diet and on a diet without prostaglandin precursors].
The effects of diet lack of precursors of prostaglandins on the rat's gastrointestinal tract are described. Afterwards the different seriousness of the ulcerative lesions caused by indomethacin on normal rats and on rats kept on a diet lack of precursors of prostaglandins is weighed. The achieved experiment permits to confirm the cytoprotective effect of prostaglandins on the gastrointestinal tract and to suppose this effect should take place above all in reply to ulcerogenic exogenous stimulants.
D000818:Animals; D004041:Dietary Fats / Q000008:administration & dosage*; D007213:Indomethacin / Q000494:pharmacology*; D007410:Intestinal Diseases / Q000517:prevention & control*; D007422:Intestines / Q000033:anatomy & histology / Q000187:drug effects*; D011453:Prostaglandins / Q000502:physiology*; D051381:Rats; D014456:Ulcer / Q000517:prevention & control
D004041:Dietary Fats; D011453:Prostaglandins; D007213:Indomethacin
Effetti dell'indometacina in ratti a dieta normale e a dieta carente in precursori delle prostaglandine.