Reversal of non-depolarising neuromuscular block in children: a comparison of atropine and glycopyrrolate in a mixture with neostigmine.
Atropine and glycopyrrolate were compared when given in a mixture with neostigmine for the reversal of non-depolarising neuromuscular block in children. Glycopyrrolate was an effective antimuscarinic agent and could be safely used as an alternative to atropine, although the advantages in this age group were not as marked as have been observed in adults.
D001285:Atropine / Q000494:pharmacology*; D002648:Child; D002675:Child, Preschool; D006024:Glycopyrrolate / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007223:Infant; D009388:Neostigmine / Q000494:pharmacology*; D009469:Neuromuscular Junction / Q000187:drug effects*; D010197:Pancuronium / Q000037:antagonists & inhibitors; D011759:Pyrrolidines / Q000494:pharmacology*; D012472:Salivation / Q000187:drug effects; D014403:Tubocurarine / Q000037:antagonists & inhibitors
D011759:Pyrrolidines; D009388:Neostigmine; D001285:Atropine; D010197:Pancuronium; D006024:Glycopyrrolate; D014403:Tubocurarine