title: Effects of estrogens P-1496 and P-1560 on the binding of estradiol with rat uterine estrogen receptors.
abstract: The interference of two weak estrogens (P-1496 and P-1560) on the binding of estradiol with uterine estrogen receptors is comparatively studied. Both P-1496 and P-1560 decrease the estradiol binding capacity, but P-1560 is less effective than P-1496. Since P-1496 is a more potent estrogenic substance than P-1560, the results obtained confirm that the uterotrophic activity of estrogens is related to the binding capability to uterine estrogen receptors.
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D002369:Castration; D004958:Estradiol / Q000378:metabolism*; D045166:Estradiol Congeners / Q000494:pharmacology*; D005260:Female; D051381:Rats; D011960:Receptors, Estrogen / Q000187:drug effects / Q000378:metabolism*; D012118:Resorcinols / Q000494:pharmacology*; D013237:Stereoisomerism; D014599:Uterus / Q000378:metabolism*; D015025:Zearalenone; D015029:Zeranol / Q000494:pharmacology*
chemical_list: D045166:Estradiol Congeners; D011960:Receptors, Estrogen; D012118:Resorcinols; D004958:Estradiol; D015025:Zearalenone; D015029:Zeranol; C028226:taleranol