[Thiocarbamic and carbamic esters of benzenedithiols with antimycotic activity].
o-, m- and p-phenylen esters of some dithio and thiol carbamic acids N-monosubstituted were prepared and tested for in vitro antifungal activity. The substances studied [Tables I leads to III; substances (I leads to XXI) were all new and were prepared by the reaction of benzenethiols with suitable isothiocyanates or isocyanates. The fungistatic activity of the products was tested in vitro against the four following strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results show that the diesters of N-monosubstituted carbamic acids of benzen-1,2-dithhiol (Table I) have marked antimycotic activity, of the same order or greater than that of clotrimazol. Among the thiocarbamic and carbamic diesters of benzen-1,3- and 1,4-dithiol, the most active are the N-benzyl- and N-beta-phenyethyldithiocarbamic derivatives.
D000935:Antifungal Agents / Q000138:chemical synthesis*; D002219:Carbamates / Q000138:chemical synthesis; D003022:Clotrimazole / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013859:Thiocarbamates / Q000138:chemical synthesis
D000935:Antifungal Agents; D002219:Carbamates; D006571:Heterocyclic Compounds; D013859:Thiocarbamates; D003022:Clotrimazole
Esteri tiocarbammici e carbammici di benzenditoli ad attività antimicotica.