Testicular function in Klinefelter's syndrome.
Testicular venous effluent was obtained by selective catheterization from 2 subjects with chromatin-positive Klinefelter's syndrome. In both of these subjects the testosterone concentration was reduced, whereas the estradiol concentration was normal or slightly increased in 1 and reduced to a much lesser extent than the testosterone level in the other. The testosterone/estradiol ratios in both subjects were in the range of 180, whereas in the normal subjects the mean testosterone/estradiol ratio in the spermatic venous effluent was 582.
D000293:Adolescent; D000328:Adult; D004958:Estradiol / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007713:Klinefelter Syndrome / Q000503:physiopathology*; D008297:Male; D013737:Testis / Q000378:metabolism*; D013739:Testosterone / Q000097:blood / Q000378:metabolism*
D013739:Testosterone; D004958:Estradiol