title: [Comparative effectiveness of different biologically active compounds during physical loading].
abstract: Over 30 drugs and recipes were assessed in 440 provocative bicycle ergometry tests (PWC170) and individual tolerance (IT) tests proposed by the authors in which 63 healthy volunteers participated. In the study the IT test was physiologically substantiated, and performance evaluation based on PWC170, when heart rate influencing drugs were taken, was shown to be incorrect. In the course of normal and forced breathing (gas exchange measurements) quantitative variations of PWC170 were recorded. On the basis of the study the combination of the two tests, having criterion properties and subjected to the rank evaluation, can be recommended as a method for determining physical work capacity and testing drug efficiency. During an exposure to adverse environments or functional, humoral or integrative stresses the following drugs can be prescribed: drugs classified as adaptogens of the USSR flora; multicomponent tonic recipes, containing aminoacids, metabolites, adaptogens, vitamins and metal compounds: recipes containing aminoacids and anabolics as well as low doses of CNS stimulants. It is suggested that pretreatment with aminoacids and anabolics assuring the basal energy potential enhances the effective influence of stimulants on the energy forming capacity and neuromuscular function without nerve cell breakdown in cases of extremely heavy loads and ensuing fatigue.
mesh_terms: D000328:Adult; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D010600:Pharmacology; D005082:Physical Exertion / Q000187:drug effects*; D012119:Respiration / Q000187:drug effects
vernacular_title: Sravnitel'naia éffektivnost' razlichnykh biologicheski aktivnykh soedineniĭ pri fizicheskikh nagruzkakh.