Studies on the disappearance of palmitate-1-14C from the plasma of pregnant rats.
Intravenously injected radioactive fatty acids disappear from the circulation at an ever-decreasing rate; about 1% of the injected label remains in plasma for hours. This slow elimination of label can be explained by an extensive recycling of label or by a slows turnover of a portion of the injected label. The results show that a recycling of label can not be responsible for the slow elimination of label, because 1. the specific activities of the tissue fatty acids were much lower than the specific activity of the plasma free fatty acids, and 2. reinjection of the remaining label of 1% into control animals showed the same slow elimination of label. An interpretation of the experiments could be that some fatty acids (about 1%) have a dissociation rate from albumin that is much lower than others, and thus they might be responsible for the late portion of the disappearance curve.
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D002250:Carbon Radioisotopes; D005260:Female; D008954:Models, Biological; D009132:Muscles / Q000378:metabolism; D010169:Palmitic Acids / Q000097:blood*; D011247:Pregnancy; D011270:Pregnancy, Animal; D051381:Rats; D014280:Triglycerides / Q000097:blood / Q000378:metabolism
D002250:Carbon Radioisotopes; D010169:Palmitic Acids; D014280:Triglycerides