Nicotinic acid hydrazide carcinogenesis in mice.
Nicotinic acid hydrazide was administered as a 0.125% solution in drinking water continuously for life from 6 weeks of age to randomly bred Swiss albino mice. As a result of treatment, the lung tumor incidence rose from 25 to 76% in females and from 26 to 42% in males. The treatment had no statistically significant effect on the development of other types of tumors. Histopathologically the tumors were classified as adenomas and adenocarcinomas of the lungs. The study thus demonstrates the tumorigenicity of this compound which is a structural homologue of the tuberculostatic and carcinogenic isonicotinic acid hydrazide.
D000230:Adenocarcinoma / Q000139:chemically induced; D000236:Adenoma / Q000139:chemically induced; D000818:Animals; D002273:Carcinogens; D004032:Diet; D004326:Drinking; D005260:Female; D006834:Hydrazines / Q000633:toxicity*; D008175:Lung Neoplasms / Q000139:chemically induced*; D008297:Male; D051379:Mice; D009539:Nicotinic Acids / Q000633:toxicity*; D012737:Sex Factors; D013997:Time Factors
D002273:Carcinogens; D006834:Hydrazines; D009539:Nicotinic Acids; C028571:nicotinic acid hydrazide