Synthesis of [8-alpha-hydroxyisocaproic acid]oxytocin. Biological activities and comparison of its in vivo uterine actions to those of deamino-[8-alpha-hydroxyisocaproic acid]oxytocin, deamino-oxytocin and oxytocin.
The synthesis and biological activities of [8-alpha-hydroxyisocaproic acid]oxytocin are reported. The in vivo uterine responses to [8-alpha-hydroxyisocaproic acid] oxytocin are prolonged and those to deamino-[8-alpha hydroxyisocaproic acid] oxytocin (as well as those we have previously reported for deamino-oxytocin) are very prolonged as compared with those of oxytocin. Time courses of the in vivo uterine responses to deamino-[8-alpha-hydroxyisocaproic acid]oxytocin and deamino-oxytocin (as followed by plotting the intervals between the individual contractions of a response vs. time after peptide injection) differ from those to [8-alpha-hydroxyisocaproic acid]oxytocin and oxytocin.
D000818:Animals; D001681:Biological Assay; D005260:Female; D007202:Indicators and Reagents; D007700:Kinetics; D008722:Methods; D008893:Milk Ejection / Q000187:drug effects; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D013329:Structure-Activity Relationship; D014590:Uterine Contraction / Q000187:drug effects; D014599:Uterus / Q000187:drug effects*
D007202:Indicators and Reagents; C004748:deaminooxytocin; D010121:Oxytocin; C021168:oxytocin, deamino-(8-alpha-hydroxyisocaproic acid)-; C028802:oxytocin, (8-alpha-hydroxyisocaproic acid)-