title: Acrosclerosis associated with vibration: an electron microscopic study.
abstract: A case of typical vibration-induced acrosclerosis was studied with the electron microscope. In addition to increased collagenization of the dermis, vascular wall and perivascular spaces, a severe vacuolization and an increased number of lysosomes in the vascular endothelia cells were observed. In many peripheral nerves, axonal degeneration, demyelination and an extensive collagenization of peri- and endoneurium were observed. These changes appeared to be the organic basis for sclerosis and neuropathies of this condition.
mesh_terms: D000328:Adult; D001808:Blood Vessels / Q000648:ultrastructure; D003094:Collagen / Q000378:metabolism; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D009784:Occupational Diseases / Q000209:etiology*; D010525:Peripheral Nerves / Q000648:ultrastructure; D011928:Raynaud Disease / Q000209:etiology* / Q000378:metabolism; D012594:Scleroderma, Localized / Q000209:etiology* / Q000378:metabolism; D012867:Skin / Q000648:ultrastructure*; D014732:Vibration / Q000009:adverse effects*
chemical_list: D003094:Collagen