[Pharmacokinetic effects of the preparation pyramem on experimental animals].
The authors examined resorption and distribution of the preparation pyramem (2-oxo-1-pyrrolidinacetamide), synthesized by RICPI and the obtained data were compared with literary data on the preparation pyracetam. Gas chromatographic method, described in the literature, was introduced for determination of concentration of pyracetam in plasma using some modifications. The obtained results and the pharmacokinetic parameters, estimated on the basis of the results, showed good coincidence with those reported in literature. The established quick resorption, the course of plasma curves after oral and venous application and biologic half-life of pyramem in rats gave foundation to conclude that the synthesized by RICPI 2-oxy-1-pyrrolidinacetamide was identical with preparation pyracetam.
D000042:Absorption; D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007700:Kinetics; D008297:Male; D010889:Piracetam / Q000008:administration & dosage / Q000378:metabolism*; D011760:Pyrrolidinones / Q000378:metabolism*; D051381:Rats; D013997:Time Factors
D011760:Pyrrolidinones; D010889:Piracetam
Prouchvane vûrkhu niakoi farmakokinetichni otnasianiia na preparata piramem v opitni zhivotni.