The treatment of heroin addiction: naltrexone alone and with behavior therapy.
Recently, narcotic antagonists (drugs which block the euphoric effects of opiates) and behavior therapy have both been proposed as possible treatments for heroin addiction. In the present study the effectiveness of one particular antagonist, naltrexone, was examined under two conditions: (1) when administered alone, and (2) when administered in conjunction with behavior therapy. Measures of treatment effect included number of days on naltrexone, number of weeks in the program, reported side effects, and number of dirty urines in each treatment. While data initially indicated a superiority of the combined treatment program, this superiority faded over time. Results are discussed in terms of program start-up effects (especially when using experimental drugs), terms of process versus outcome measurement, and in terms of societal pressure operating against the success of heroin treatment in minority populations with poor job skills.
D000328:Adult; D001521:Behavior Therapy; D005108:Extinction, Psychological / Q000187:drug effects; D006556:Heroin Dependence / Q000628:therapy*; D006801:Humans; D008297:Male; D009270:Naloxone / Q000031:analogs & derivatives*; D009271:Naltrexone / Q000009:adverse effects / Q000627:therapeutic use*; D010043:Outcome and Process Assessment, Health Care; D010352:Patient Dropouts
D009270:Naloxone; D009271:Naltrexone