[Liver cell membrane autoantibody (LMA) in chronic liver disease].
The incidence of LMA, detected by indirect IF on isolated rabbit hepatocytes, was significantly higher in CAH-non B (58%) than in CAH-B (15%). Sera from AVH patients showed a smaller percentage of positivity whereas the CPH patients were negative. The organ-specificity, the high incidence in relation to other non-organ-specific autoantibodies and the inverse correlation with the markers of HB Virus, make LMA a specific and sensitive marker of "autoimmune" chronic liver disease.
D000208:Acute Disease; D000818:Animals; D001323:Autoantibodies / Q000276:immunology*; D002462:Cell Membrane / Q000276:immunology; D002908:Chronic Disease; D006505:Hepatitis / Q000276:immunology; D006509:Hepatitis B / Q000276:immunology*; D006525:Hepatitis, Viral, Human / Q000276:immunology; D006801:Humans; D008099:Liver / Q000276:immunology*; D008103:Liver Cirrhosis / Q000276:immunology; D008107:Liver Diseases / Q000276:immunology*; D011817:Rabbits; D051381:Rats
D001323:Autoantibodies
Autoanticorpi anti-membrana epatocitaria (LMA) nelle epatopatie croniche.