beta-Adrenergic stimulation of respiratory ciliary activity.
We investigated the effect of isoproterenol on ciliary activity using a mucus-free preparation of cultured ciliated cells of the rabbit trachea. The frequency of ciliary beating was monitored by dynamic laser-scattering spectroscopy. The results demonstrated that isoproterenol directly stimulates the activity of ciliated cells of the respiratory epithelium and that this effect is beta-adrenergic specific inasmuch as the observed stimulation can be blocked by propranolol.
D000818:Animals; D002923:Cilia / Q000187:drug effects* / Q000502:physiology; D007545:Isoproterenol / Q000494:pharmacology*; D007834:Lasers; D011433:Propranolol / Q000494:pharmacology*; D011817:Rabbits; D014132:Trachea
D011433:Propranolol; D007545:Isoproterenol