Tetracycline transport in Bacteroides fragilis.
In susceptible strain of Bacteroides fragilis, tetracycline uptake is biphasic. The initial phase is independent of adenosine 5'-triphosphate synthesis, which is coupled to fumarate reduction; this phase is not altered by expression of tetracycline resistance genes in a resistant strain. The second phase appears to occur by active transport, since it is largely reduced by rotenone, an inhibitor of electron transport to fumarate; moreover, this phase is under negative control of the tetracycline resistance gene.
D001441:Bacteroides fragilis / Q000187:drug effects / Q000378:metabolism*; D001692:Biological Transport; D004352:Drug Resistance, Microbial; D004579:Electron Transport; D005650:Fumarates / Q000378:metabolism; D012402:Rotenone / Q000494:pharmacology; D013752:Tetracycline / Q000378:metabolism*
D005650:Fumarates; D012402:Rotenone; D013752:Tetracycline