Contrast enhancement of malignant tumors after intravenous polyvinylpyrrolidone with metallic salts as determined by computed tomography.
Rabbits with V2 carcinoma thigh implants received intravenous injections of solutions of polyvinylpyrrolidone (PVP) and metallic salts. This resulted in dense contrast enhancement of the carcinomas in some of the studies, as determined both by computed tomography (CT) and conventional radiography. The contrast enhancement lasted for several weeks, greatly facilitating tumor detection. The magnitude and duration of this contrast enhancement would be expected to improve CT detection of small lesions and to be useful in evaluating the efficacy of therapy.
D000818:Animals; D001729:Bismuth; D005290:Ferric Compounds; D007275:Injections, Intravenous; D008297:Male; D008670:Metals / Q000008:administration & dosage; D009374:Neoplasms, Experimental / Q000000981:diagnostic imaging / Q000473:pathology; D011205:Povidone / Q000008:administration & dosage; D011817:Rabbits; D011856:Radiographic Image Enhancement; D012492:Salts; D012974:Sodium Iodide; D012983:Soft Tissue Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D013644:Tartrates; D014057:Tomography, X-Ray Computed
D005290:Ferric Compounds; D008670:Metals; D012492:Salts; D013644:Tartrates; D012974:Sodium Iodide; D011205:Povidone; D001729:Bismuth