Neo-antigenic expression in rheumatoid synovia?
CEA-like activity was found in eight synovial samples of ten rheumatoid patients and in two samples of patients with recurrent arthrosynovitis. No CEA-like activity was found instead in seven synovial samples of patients with gonarthrosis. The plasmatic values result always within normal range in the non-rheumatoid patients and high only in two cases of rheumatoid ones. Since enzymatic proteolysis induces a synovial CEA-like activity fall, the A.A. think that the antigenic determinants belong to a "protein" locally synthesized.
D000328:Adult; D001172:Arthritis, Rheumatoid / Q000276:immunology*; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D006801:Humans; D008875:Middle Aged; D013583:Synovial Membrane / Q000276:immunology*
D002272:Carcinoembryonic Antigen