Ethnic difference in drug metabolism: debrisoquine 4-hydroxylation in Caucasians and Orientals.
The extent to which debrisoquine (D) is metabolized to 4-hydroxydebrisoquine (4OHD) was found to be influenced by the ethnic origin of the subjects. Following ingestion of 20 mg of debrisoquine sulfate, Orientals excreted, on the average, significantly more D and less 4OHD in 0- to 8-h urine than Caucasians; however, the sums of D + 4OHD did not differ.
D044466:Asian People; D003647:Debrisoquin / Q000378:metabolism*; D006801:Humans; D006900:Hydroxylation; D007546:Isoquinolines / Q000378:metabolism*; D044469:Racial Groups; D044465:White People
D007546:Isoquinolines; D003647:Debrisoquin