Sideroblasts and haemosiderin in thyrotoxicosis.
Bone marrow sideroblasts and haemosiderin were studied in 19 thyrotoxic patients before therapy and in the euthyroid state. The proportion of sideroblasts and the amount of haemosiderin were significantly higher in the hyperthyroid than in the euthyroid phase. Pathological sideroblasts with coarse perinuclear iron granules were found before therapy but not in the euthyroid phase. It is concluded that during thyrotoxicosis the supply of iron into erythroblasts is greater than the amount used for haemoglobin synthesis.
D000328:Adult; D000368:Aged; D001856:Bone Marrow Examination; D004900:Erythroblasts / Q000473:pathology*; D004911:Erythrocyte Volume; D004912:Erythrocytes / Q000473:pathology*; D005260:Female; D006485:Hemosiderin / Q000032:analysis*; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D006485:Hemosiderin