Moduretic-induced metabolic acidosis and hyperkalaemia.
A patient who developed significant metabolic acidosis and severe hyperkalaemia while taking Moduretic (amiloride and hydrochlorothiazide) is reported. During the period of hyperkalaemia (maximum potassium 7-6 mmol/l) the patient's whole body potassium content was normal. His acid-base balance and serum potassium returned to normal some 10 days after stopping the drug. The possible mechanism of acidosis and hyperkalaemia in this patient is discussed.
D000138:Acidosis / Q000139:chemically induced*; D000368:Aged; D000584:Amiloride / Q000009:adverse effects*; D004338:Drug Combinations; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects*; D006947:Hyperkalemia / Q000139:chemically induced*; D008297:Male; D011719:Pyrazines / Q000009:adverse effects*
D004338:Drug Combinations; D011719:Pyrazines; D006852:Hydrochlorothiazide; D000584:Amiloride