[Anatomical and functional changes of the human small intestine induced by 5-fluorouracil (author's transl)].
In 10 female patients with carcinoma the effect of a single dose of 5-fluorouracil on morphologic alterations of the small bowel mucosa, intestinal disaccharidase-activities and lactose-tolerance-test was studied pre- and 96 hours posttherapy. After having given a standard dose of 1,25-1,50 gr 5-fluorouracil intravenously ( = 22 mg per kilo body weight) histologic changes of the small bowel mucosa (slight edema and shortening of the villi) were noted only in 4 cases. In the other cases the small intestine showed no morphological alterations of the mucosa. In all patients the lactose-tolerance-test after therapy with 5-fluorouracil was not affected. Following the administration of 5-fluorouracil no reduction of intestinal disaccharidase activities (maltase, saccharase, lactase) was observed. As a consequence of our results we suppose, that a patient given a single dose of 5-fluorouracil intravenously needs no specific diet without milk or milk-products.
D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy; D004186:Disaccharidases / Q000378:metabolism; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D007413:Intestinal Mucosa / Q000187:drug effects; D007583:Jejunum / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007785:Lactose / Q000378:metabolism; D007789:Lactose Tolerance Test; D008875:Middle Aged; D012811:Sigmoid Neoplasms / Q000188:drug therapy; D014594:Uterine Neoplasms / Q000188:drug therapy
D004186:Disaccharidases; D007785:Lactose; D005472:Fluorouracil
Morphologische und funktionelle Veränderungen der Dünndarmschleimhaut des Menschen nach intravenöser Gabe von 5-Fluorouracil.