Mepacrine--ineffective in onchocerciasis.
Mepacrine in doses of 200 mg b.d. for 5-7 days given to six patients from the rain-forest zone of Nigeria showed neither micro- nor macrofilaricidal activity against Onchocerca volvulus.
D000328:Adult; D000977:Antiparasitic Agents; D006801:Humans; D008297:Male; D008842:Microfilariae / Q000187:drug effects; D008875:Middle Aged; D009549:Nigeria; D009854:Onchocerca / Q000187:drug effects; D009855:Onchocerciasis / Q000188:drug therapy*; D011796:Quinacrine / Q000627:therapeutic use*; D012867:Skin / Q000469:parasitology
D000977:Antiparasitic Agents; D011796:Quinacrine