title: Lipid deposition and metabolism in rat placenta during gestation.
abstract: Changes in placental lipid content in rats at the 15th and 20th days of pregnancy were investigates. It was found that progress of gestation is accompanied by a significant increase in triglycerides per mg placental DNA. Maternal starvation caused additional increase in the placental triglyceride content. By incubation with 14C-oleic acid, it was shown that placenta at term possesses an increased capacity to esterify fatty acids at a wide range of medium oleic acid concentrations. Increase in free fatty acid concentration caused a linear increase of their incorporation into placental lipids. Oxidation of oleic acid into CO2 was also increased with the duration of gestation, but to a lesser degree and over a narrower range of concentration than esterification, suggesting an increased channelling of fatty acids into glycerides.
mesh_terms: D000818:Animals; D004951:Esterification; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000378:metabolism*; D005260:Female; D009829:Oleic Acids / Q000378:metabolism; D010084:Oxidation-Reduction; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D014280:Triglycerides / Q000378:metabolism*
chemical_list: D005230:Fatty Acids, Nonesterified; D009829:Oleic Acids; D014280:Triglycerides