Antioxidants as agents reducing the toxicity of indomethacin.
Simulataneous oral administration of butylhydroxytoluene (BHT) (50 or 100 mg/kg) with indomethacin (IND) (3, 6 or 20 mg/kg) prevented the damaging effect of IND on the rat gastric mucosa. Butylhydroxyanisole (BHA) and nordihydroguiaretic acid (NDGA) rather potentiated than prevented the noxious action of IND. A reduction of IND toxicity without affecting its anti-inflammatory action seems to be possible to achieve by concomitant administration of IND with BHT.
D000284:Administration, Oral; D000818:Animals; D000975:Antioxidants / Q000008:administration & dosage / Q000494:pharmacology*; D002083:Butylated Hydroxyanisole / Q000494:pharmacology; D002084:Butylated Hydroxytoluene / Q000494:pharmacology; D002396:Catechols / Q000494:pharmacology; D004347:Drug Interactions; D005753:Gastric Mucosa / Q000187:drug effects*; D007213:Indomethacin / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D009637:Masoprocol; D051381:Rats
D000975:Antioxidants; D002396:Catechols; D002084:Butylated Hydroxytoluene; D002083:Butylated Hydroxyanisole; D009637:Masoprocol; D007213:Indomethacin