Hereditary antithrombin III deficiency in an English family.
A family including four members with decreased antithrombin III (ATIII) measured by a biological and an immunological method is described. Immunologically measured levels of other coagulation inhibitors were normal. In the antithrombin III deficient family members there was a history of thrombotic disease. Turnover of 125I-antithrombin III in a deficient individual showed the lower plasma levels probably to be due to a deficiency in the rate of synthesis rather than to an increased catabolic rate.
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D020152:Antithrombin III Deficiency; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D013927:Thrombosis / Q000097:blood / Q000235:genetics*
D000990:Antithrombin III