alpha-Guanidinoglutaric acid in cobalt-induced epileptogenic cerebral cortex of cats.
Guanidino compounds in the cobalt-induced epileptogenic cerebral cortex of cats were fluorometrically analysed by a JASCO G-520 guanidino compounds analyser, and an unknown high peak was observed in the chromatogram that was identical to the peak of authentic alpha-guanidinoglutaric acid. In another experiment, the substance was extracted from the cobalt focus tissue, converted into dimethylpyrimidyl derivative-butylester, and analysed by a GC/MS technique. The mass spectrum of the substance was identical to the dimethylpyrimidyl derivative of alpha-guanidinoglutaric acid butylester (M+ = 365).
D000818:Animals; D002415:Cats; D002540:Cerebral Cortex / Q000032:analysis*; D003035:Cobalt / Q000494:pharmacology*; D005470:Fluorometry; D008401:Gas Chromatography-Mass Spectrometry; D005977:Glutarates / Q000032:analysis*; D006146:Guanidines / Q000032:analysis*; D012640:Seizures / Q000378:metabolism*
D005977:Glutarates; D006146:Guanidines; D003035:Cobalt; C028262:alpha-guanidinoglutaric acid