title: Why didn't your mother reject you?
abstract: There are two mechanisms by which the fetus escapes damage from the maternal immune response during pregnancy. First, the placenta serves as an antigen-bearing immunoabsorbent barrier between the maternal and fetal circulation, so that the mother's humoral immune response to fetal antigens derived from the paternal major histocompatibility complex has no effect on the fetus. Second, the placenta serves as a physical barrier to the entry of maternal antifetal lymphocytes and thus prevents the maternal cell-mediated immune response from harming the fetus. Evidence supporting these two mechanisms is presented in this paper.
mesh_terms: D000818:Animals; D000917:Antibody Formation; D005260:Female; D005333:Fetus / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology; D006649:Histocompatibility Antigens / Q000276:immunology*; D006801:Humans; D007111:Immunity, Cellular; D007231:Infant, Newborn; D008285:Major Histocompatibility Complex; D008431:Maternal-Fetal Exchange; D051379:Mice; D008895:Milk, Human / Q000276:immunology; D010920:Placenta / Q000276:immunology*; D011247:Pregnancy
chemical_list: D006680:HLA Antigens; D006649:Histocompatibility Antigens