[Urinary excretion of fibrin degradation products in children with nephrotic syndrome (author's transl)].
In glomerular disease the urinary excretion of fibrin degradation products (FDP) has prognostic value. In a prospective longitudinal study of 120 cases of idiopathic nephrotic syndrome the urinary FDPs have been measured. The results have been correlated to the proteinuria, plasma FDPs, the renal biopsy appearance, the response to steroid therapy and the outcome. During relapse in steroid sensitive or dependent nephrotic syndrome the urinary excretion of FDPs is low. In steroid resistant nephrotic syndrome with a poor prognosis there was a prolonged and raised excretion of FDPs (> 3 micrograms/ml) that preceeded the phase of progressive renal failure and corresponded to glomerular segmental hyalinisation. The significance of this finding is not clear. Fibrinogen is probably filtered in the glomerulus with subsequent fibrinolysis in the urine. This mechanism is proposed because of the inverse correlation between urine FDPs and the selectivity of the proteinuria, variable plasma FDP levels and only occasional deposition of fibrin in the glomerulus.
D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000652:urine*; D006801:Humans; D007223:Infant; D008297:Male; D009404:Nephrotic Syndrome / Q000503:physiopathology / Q000652:urine*; D011379:Prognosis
D005338:Fibrin Fibrinogen Degradation Products
Excrétion urinaire des produits de dégradation de fibrine/fibrinogène dans les néphroses de l'enfant. Intérêt pronostique et signification physiopathologique.