Effect of some lipophilic substances on fluorescence polarization of perylene in lipid vesicles and mitochondrial membranes.
Short-chain ubiquinones were observed to increase the fluorescence polarization associated with perylene, indicating a decrease in the fluidity of the mitochondrial membrane. The results indicated that the perturbation induced by low homologs results indicated that the perturbation induced by low homologs of ubiquinone on the physical state of membrane lipids is quite different from that of other lipophilic substances which have been considered.
D000818:Animals; D001551:Benz(a)Anthracenes / Q000378:metabolism*; D002417:Cattle; D003902:Detergents / Q000494:pharmacology; D005454:Fluorescence Polarization; D008560:Membrane Fluidity / Q000187:drug effects*; D008563:Membrane Lipids / Q000378:metabolism*; D008567:Membranes, Artificial; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D010569:Perylene / Q000378:metabolism*; D013329:Structure-Activity Relationship; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000494:pharmacology*
D001551:Benz(a)Anthracenes; D003902:Detergents; D008563:Membrane Lipids; D008567:Membranes, Artificial; D014451:Ubiquinone; D010569:Perylene