title: Testing of the fungicide maneb for carcinogenicity in two populations of the European crested newt.
abstract: The carcinogenic effects of the fungicide manganese ethylenebisdithiocarbamate (maneb) have been investigated in 2 populations of adult crested newt, which have different prevalences of spontaneous melanoma. Animals were exposed percutaneously to a 5 ppm solution of maneb 4 days a week for 37 weeks. No differences in tumor incidence were found between control and maneb-treated animals of either population. Most of the control and treated animals from Settala (Milan) died within 7 months because of the development of widely disseminated  melanomas. Tumor incidence was 94% in controls and 98% in maneb-treated newts. In the population from Bagnaia (Perugia) the incidences of melanoma were 7% and 2%, respectively.
mesh_terms: D000818:Animals; D005028:Ethylenebis(dithiocarbamates) / Q000378:metabolism / Q000633:toxicity*; D005260:Female; D008297:Male; D008545:Melanoma / Q000139:chemically induced / Q000662:veterinary*; D009362:Neoplasm Metastasis; D012455:Salamandridae; D012878:Skin Neoplasms / Q000139:chemically induced / Q000662:veterinary*; D013859:Thiocarbamates / Q000633:toxicity*
chemical_list: D005028:Ethylenebis(dithiocarbamates); D013859:Thiocarbamates