[Mutagenic action resulting from the preovulatory administration of chloridine on preimplantation rat embryos].
Pyrimethanine (2 and 5 mg/kg) injected to the adult female rats just before ovulation causes significant dose-dependent reduction in embryo cleavage rate. Pyrimethamine administered in a dose of 2 mg/kg before ovulation has no mutagenic effect on 5-day rat embryos, while 5 mg/kg induced chromosomal aberrations in 14.3% of all 5-day embryos as compared to only 6.3 % embryos with chromosomal aberrations in the control animals. The most common types of chrmosomal aberrations induced by pyrimethamine are trisomy and chromosomal mosaicism.
D000818:Animals; D000962:Antimalarials / Q000494:pharmacology*; D002869:Chromosome Aberrations; D002875:Chromosomes / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D047108:Embryonic Development / Q000187:drug effects*; D005260:Female; D007621:Karyotyping; D009153:Mutagens; D010060:Ovulation / Q000187:drug effects*; D011247:Pregnancy; D011359:Proestrus / Q000187:drug effects; D011739:Pyrimethamine / Q000494:pharmacology*; D051381:Rats
D000962:Antimalarials; D009153:Mutagens; D011739:Pyrimethamine
Mutagennyi éffekt predovuliatornogo vvedeniia khloridina na doimplantatsionnye zarodyshi krys.