[Transient bisalbuminemia induced by penicillin and gentamicin. Immunoelectrophoretic study and thorough examination of bibliography (author's transl)].
The Authors report a case of transient bisalbuminemia due to the administration of large doses of penicillin and gentamicin. Cellulose acetate electrophoresis showed an abnormal fraction of normal albumin. The IEB showed a better result. Transient bisalbuminemia may indicate saturation of albumin sites with beta-lactamines, requiring interruption of therapy. The Authors point out the utility of IEB in disclosing this alteration induced by antibiotics.
D000368:Aged; D001796:Blood Protein Disorders / Q000139:chemically induced*; D004359:Drug Therapy, Combination; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007123:Immunoelectrophoresis, Two-Dimensional; D010400:Penicillin G / Q000008:administration & dosage / Q000009:adverse effects*; D012709:Serum Albumin / Q000032:analysis
D005839:Gentamicins; D012709:Serum Albumin; D010400:Penicillin G
Bisalbuminemia transitoria da penicillina piu' gentamicina. Studio immunoelettroforetico e revisione bibliografica.