A metabolite of a structural analog of thalidomide lacks teratogenic effect in pregnant rhesus monkeys.
A metabolite of CG 3033, a structural analog of thalidomide, was examined for teratogenic potential in rhesus monkeys. The metabolite EM 240 is produced in man by hydrolysis of the parent compound but the pathway is absent in nonhuman primates. Fifteen mg/kg administered orally throughout organogenesis to pregnant rhesus monkeys produced no evidence of embryotoxicity, including malformation.
D000014:Abnormalities, Drug-Induced / Q000453:epidemiology; D000818:Animals; D004353:Drug Evaluation, Preclinical; D005260:Female; D008251:Macaca / Q000196:embryology*; D008253:Macaca mulatta / Q000196:embryology*; D011247:Pregnancy; D013723:Teratogens; D013792:Thalidomide / Q000031:analogs & derivatives* / Q000494:pharmacology
D013723:Teratogens; D013792:Thalidomide; C027949:EM 240