Cerebral and systemic amino acid metabolism in experimental acute amphetamine poisoning in guinea pigs.
Protein catabolism, as measured by plasma amino acids is increased by amphetamine injection (15 mg/kg body wt) administered to 10 adult male guinea pigs. Changes in the cerebrospinal fluid were less marked than those in the plasma. The amphetamine seemed to inhibit the enzymes of the metabolic pathways that use amino acids.
D000596:Amino Acids / Q000097:blood / Q000134:cerebrospinal fluid / Q000378:metabolism*; D000601:Amino Acids, Essential / Q000378:metabolism; D000662:Amphetamines / Q000633:toxicity*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D006168:Guinea Pigs; D008297:Male
D000596:Amino Acids; D000601:Amino Acids, Essential; D000662:Amphetamines