[Calcium metabolism study performed by means of Ca-45 in bone diseases and idiopathic hypercalciuria].
The authors analyse the results obtained during 54 radioisotope investigations using 45Ca in 13 cases of idiopathic hypercalciuria, 12 cases of osteoporosis, 3 cases of Paget's disease, and 2 cases of osteomalacia including one of Fanconi's disease in an adult. In 12 patients, repetition of the radio-isotope test two, three or four times; permitted the authors to study the effects of the treatments administered: calcitonin, phosphate, vitamin D, parathormon, oestrogen. Calcitonin increases intestinal absorption and reduces bone reabsorption and also accretion. Phosphate greatly increases accretion and bone reabsorption in vitamin-resistant osteomalacia of adults. The synthetic fragment 1--34 of human parathormone increases accretion and reabsorption but does not modify the calcium balance. The addition of estrogen reduces reabsorption and slightly increases accretion in two osteoporotic patients producing a positive calcium balance. This method of investigation is of great interest to assess the effects of a drug on calcium metabolism and on the two processes of bone remodelling.
D000368:Aged; D001847:Bone Diseases / Q000188:drug therapy / Q000378:metabolism*; D002116:Calcitonin / Q000627:therapeutic use; D002118:Calcium / Q000378:metabolism* / Q000652:urine; D002128:Calcium Metabolism Disorders / Q000188:drug therapy / Q000378:metabolism*; D002132:Calcium Radioisotopes; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000378:metabolism; D010018:Osteomalacia / Q000378:metabolism; D010024:Osteoporosis / Q000378:metabolism
D002132:Calcium Radioisotopes; D002116:Calcitonin; D002118:Calcium
Etude du métabolisme calcique réalisée à l'aide du 45Ca dans les maladies osseuses et dans l'hypercalciurie idiopathique.