title: [Stereospecificity of hypothalamo-hypophysial dopamine receptors involved in the control of prolactin secretion in normal man: effects of sulpiride stereoisomers].
abstract: The sterical requirements of dopamine (DA) receptors involved in the control of prolactin (PL) secretion have been analyzed by studying the effects of the administration of d- and l-sulpiride (25 mg i.v.) on PL serum levels in five normal male volunteers. Both d- and l-sulpiride cause a remarkable rise in PL serum levels, the only difference between the two drugs being the lower decay rate of hormone levels after the l-isomer. The results obtained are discussed in the frame of a possible low steric selectivity of DA receptors controlling PL secretion in the hyposthalamo-pituitary axis.
mesh_terms: D000328:Adult; D006801:Humans; D008297:Male; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D012016:Reference Values; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013469:Sulpiride / Q000494:pharmacology*
chemical_list: D011954:Receptors, Dopamine; D013469:Sulpiride; D011388:Prolactin
vernacular_title: Stereospecificita' dei recettori dopaminergici ipotalamo-ipofisari coinvolti nel controllo della secrezione di prolattina nell'uomo normale: effetti degli isomeri della sulpiride.