[Action of some psychotropic drugs on the electrmyographic response evoked by stretches of the gastrocnemius muscle of rats submitted to stress].
Electromyographic response evoked by stretches is registered in the rat gastrocnemius muscle. Stretch is caused by the forced flection of the paw on the leg by a solenoid. Intensity of the electromyographic signal is measured by an electronic integrator. We studied the dose/effect correlation of some psycotropic drugs on the stretch reflex in stressed rats by contention: Pentobarbital, Meprobamate, Chlorpromazine, Sulpiride, Amitriptyline, D-Amphetamine. Chlorpromazine abolishes the myoelectric stretch response while Meprobamate and Amitriptyline reduce it only a little. Pentobarbital and Sulpiride produce a biphasyc effect of opposite sign: at small doses Pentobarbital increases the stretch response while Sulpiride reduces it. At high doses we can see an opposite effect. Amphetamine, at least, at all studied doses decreases the myoelectric stretch response.
D000639:Amitriptyline / Q000494:pharmacology; D000818:Animals; D002746:Chlorpromazine / Q000494:pharmacology; D003913:Dextroamphetamine / Q000494:pharmacology; D008620:Meprobamate / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects*; D009126:Muscle Relaxation / Q000187:drug effects*; D009132:Muscles / Q000187:drug effects / Q000503:physiopathology*; D010424:Pentobarbital / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology*; D013469:Sulpiride / Q000494:pharmacology
D011619:Psychotropic Drugs; D000639:Amitriptyline; D013469:Sulpiride; D008620:Meprobamate; D010424:Pentobarbital; D003913:Dextroamphetamine; D002746:Chlorpromazine
Azione di alcuni psicofarmaci sulla risposta elettromiografica del riflesso di stiramento del gastrocnemio di ratto sottoposto a stress.