Glycine enhancement of caudate neuronal activities: relationship with the dopaminergic nigrostriatal pathway.
Glycine microinjection into the substantia nigra zona compacta (SNC) in lightly anesthetized rats produced a marked and rapid decrease in spontaneous discharges of SNC neurons and a simultaneous enhancement of caudate nucleus (CN) activities. In animals pretreated with the dopamine receptor blocker, haloperidol, intranigral microinjection of glycine produced a dissociation of the nigral inhibition and caudate excitation. The SNC neurons were similarly suppressed while the CN neurons exhibited no discernible change in firing frequency. A possible role was suggested for glycine as an inhibitory neurotransmitter acting on the cells of origin of the nigrostriatal pathway.
D000818:Animals; D002421:Caudate Nucleus / Q000187:drug effects* / Q000502:physiology; D004594:Electrophysiology; D005998:Glycine / Q000494:pharmacology*; D006220:Haloperidol / Q000494:pharmacology; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D009474:Neurons / Q000187:drug effects; D051381:Rats; D011954:Receptors, Dopamine / Q000187:drug effects*; D013378:Substantia Nigra / Q000187:drug effects* / Q000502:physiology
D011954:Receptors, Dopamine; D006220:Haloperidol; D005998:Glycine