The auto-induction of carbamazepine during long-term therapy.
Healthy male volunteers during regular therapy of carbamazepine had a statistically significant decrease in their plasma drug levels during a period of 28 days. The same phenomenon was also registered in epileptic patients in the course of their long-term monotherapy with carbamazepine. Neither in volunteers nor in epileptics did any statistically significant change in the plasma levels of carbamazepine-10,11-epoxide occur. Wide fluctuations between the fasting and peak plasma level of carbamazepine were found in epileptics. Neither the fasting nor peak plasma levels of the drug correlated in a statistically significant degree with the daily dose of carbamazepine.
D000293:Adolescent; D000328:Adult; D001711:Biotransformation; D002220:Carbamazepine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D004827:Epilepsy / Q000378:metabolism; D005260:Female; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D002220:Carbamazepine