La crosse virus production and export have a colchicine-sensitive step.
In the present investigation, the effect of colchicine on La Crosse virus production and export was tested. Colchicine-treated, La Crosse virus-infected cells: (1) had decreased mean virus titers compared with those of control cells; (2) had a ratio of released to cell-associated virus of 1-1.9 whereas control cells had a ratio of 13. A colchicine-sensitive step, possibly involving microtubules, may be involved in virus production and/or release from the cell.
D000818:Animals; D002043:Bunyaviridae / Q000254:growth & development*; D002460:Cell Line; D003078:Colchicine / Q000494:pharmacology*; D006224:Cricetinae; D002141:Encephalitis Virus, California / Q000187:drug effects / Q000254:growth & development* / Q000378:metabolism; D008870:Microtubules / Q000502:physiology
D003078:Colchicine