Concentration of antibiotics in simple renal cysts.
Patients with infected renal cysts are known to respond poorly to antibiotic therapy. We evaluated the serum, cyst fluid and urine levels of 3 antibiotics in 4 patients with simple renal cysts. Despite excellent urine and serum concentrations gentamicin was detected in the cyst of only 1 of the 3 patients studied. Neither sulfamethoxazole nor trimethoprim was detected in the cyst of 1 patient despite adequate plasma levels. These data help explain the poor medical response of such patients and support the concept of early surgical intervention.
D000900:Anti-Bacterial Agents / Q000032:analysis*; D005839:Gentamicins / Q000032:analysis / Q000627:therapeutic use; D006801:Humans; D052177:Kidney Diseases, Cystic / Q000378:metabolism*; D011379:Prognosis; D013420:Sulfamethoxazole / Q000032:analysis / Q000627:therapeutic use; D014295:Trimethoprim / Q000032:analysis / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D014295:Trimethoprim; D013420:Sulfamethoxazole