Genetic influence on brain catecholamines: high brain noradrenaline in salt-sensitive rats.
1. Rats genetically sensitive to salt-induced hypertension showed higher levels of plasma noradrenaline and adrenaline than rats genetically resistant to hypertension. 2. The hypertension-sensitive rats had higher hypothalamic noradrenaline and lower adrenaline than resistant rats. 3. In response to a high salt diet brain-stem noradrenaline increased in sensitive rats and resistant rats exhibited a decrease on the same diet.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D001933:Brain Stem / Q000378:metabolism; D004039:Diet, Sodium-Restricted; D004837:Epinephrine / Q000378:metabolism; D006973:Hypertension / Q000235:genetics* / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D012964:Sodium / Q000378:metabolism; D013997:Time Factors
D012964:Sodium; D009638:Norepinephrine; D004837:Epinephrine