title: [Acute mixed portal hypertension. Experimental study (author's transl)].
abstract: Experimental studies were conducted in dogs to establish a new model for portal hypertension. The model chosen depends on partial obstruction of the portal vein to obtain a portal pressure of 11 +/- 4 ml. and the injection of 600 U. of secretin over a period of 35 min. The validity of the model was demonstrated by hemodynamic studies which resulted in a portal pressure, mesenteric blood flow, and mesenteric vascular resistances similar to those observed in clinical practice (hepatic cirrhosis).
mesh_terms: D000208:Acute Disease; D000818:Animals; D003250:Constriction; D004195:Disease Models, Animal; D004285:Dogs; D006439:Hemodynamics; D006975:Hypertension, Portal / Q000503:physiopathology*; D011169:Portal Vein; D012633:Secretin / Q000494:pharmacology
chemical_list: D012633:Secretin
vernacular_title: Hypertension portale aiguë mixte. Une étude expérimentale.