Clinical, chemical, and CT evaluation of short-term and long-term antiedema therapy with dexamethasone and diuretics.
Three independent methods were used to quantify the therapeutic effect on peritumoral brain edema with respect to different forms of treatment (dexamethasone, furosemide, and their combination with different dosages and different periods of treatment). 1. The neurological deficit evaluated by frequency distribution analysis showed an improvement in nearly all cases. In a few cases the initial improvement was followed by a secondary deterioration. The various symptoms showed significant differences in regression with regard to the extent of the reduced deficit as well as the time dependence. 2. With a certain delay (compared to item 1), diminution of brain edema was detected by CT follow-up. The effect of dexamethasone and the combination with furosemide differed depending on the nature of the brain tumor. 3. Compared to the untreated patients, the water content was reduced by nearly 3% following dexamethasone treatment 4 x 4 mg for 4 to 6 days. Following dexamethasone/furosemide therapy for 4 to 6 days, it was reduced by about 4.5%. The result of long-term therapy with dexamethasone alone was similar. The sodium content changed parallel to the water content. Dexamethasone and dexamethasone/furosemide was most effective in patients with glioblastoma, where the water content decreased by nearly 6%. The data presented suggest that preoperative antiedema treatment with dexamethasone is necessary for several days or a few weeks in some cases. The period of treatment can be reduced significantly by dexamethasone/furosemide or extremely high doses of dexamethasone. On the other hand, the results of follow-up scoring of the neurological situation show that the optimal time of pretreatment must be limited with respect to the individual case. The therapeutic results presented allow inferences to be made concerning pathophysiology of the resolution of brain edema.
D001923:Brain Chemistry; D001929:Brain Edema / Q000175:diagnosis / Q000188:drug therapy*; D001932:Brain Neoplasms / Q000150:complications / Q000601:surgery; D002712:Chlorides / Q000032:analysis; D003907:Dexamethasone / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005665:Furosemide / Q000008:administration & dosage*; D006801:Humans; D011188:Potassium / Q000032:analysis; D011300:Preoperative Care; D012964:Sodium / Q000032:analysis; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D014867:Water / Q000032:analysis
D002712:Chlorides; D014867:Water; D005665:Furosemide; D003907:Dexamethasone; D012964:Sodium; D011188:Potassium