Effect of fibrinogenolytic products D and E on fibrinogen and albumin synthesis in the rat.
Previous studies are in conflict over the effect of infusing mixed fibrinogen-fibrin degradation products on fibrinogen synthesis, as determined by changes in fibrinogen concentration or by incorporation of labeled amino acids into fibrinogen. We have injected purified homologous fragments D1 and E into rats and measured their fibrinogen and albumin synthetic rates by the [14C]carbonate technique, a method that provides quantitative estimates of hepatic secretory protein synthesis. Fibrinogen fractional synthetic rates were increased 2.5 times in animals injected with fragment D1, compared with saline-injected controls. No increase were observed in fragment E-injected animals. Neither fragment produced changes in albumin synthesis. Fragment D increased plasma fibrinogen concentration, but did not raise plasma haptoglobin levels. These results suggest that fragment D is a regulator of fibrinogen synthesis.
D000418:Albumins / Q000096:biosynthesis*; D000596:Amino Acids / Q000378:metabolism; D000818:Animals; D004591:Electrophoresis, Polyacrylamide Gel; D005338:Fibrin Fibrinogen Degradation Products / Q000494:pharmacology*; D005340:Fibrinogen / Q000096:biosynthesis* / Q000097:blood; D006242:Haptoglobins / Q000097:blood; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D012709:Serum Albumin
D000418:Albumins; D000596:Amino Acids; D005338:Fibrin Fibrinogen Degradation Products; D006242:Haptoglobins; D010446:Peptide Fragments; D012709:Serum Albumin; D005340:Fibrinogen