4-tert-butyl-2,6-diisopropylphenol: Another phenol inducing hemorrhage in rats.
Male Sprague-Dawley rats were fed with 3,5-di-tert-butylphenol, 2,4-di-tert-butylphenol, 4-tert-butyl-2,6-diisopropylphenol, 2-tert-butyl-4-sec-butylphenol or 2-,6-di-tert-butyl-4-methylphenol (BHT) at a level of 2.27 mmol% in the diet for 1 week. One rat given 4-tert-butyl-2,6diisopropylphenol died: post mortem examination revealed hematocoelia, intratesticular, intraepididymal and intramuscular hematoma. The other rats in this group suffered from severe hemorrhagic anemia; and the prothombin index was significantly decreased.
D000740:Anemia / Q000139:chemically induced; D000818:Animals; D006406:Hematoma / Q000139:chemically induced; D006470:Hemorrhage / Q000139:chemically induced*; D008297:Male; D009135:Muscular Diseases / Q000139:chemically induced; D010636:Phenols / Q000633:toxicity*; D051381:Rats; D013733:Testicular Diseases / Q000139:chemically induced
D010636:Phenols; C028478:4-tert-butyl-2,6-diisopropylphenol