title: [Pharmacologic prevention of changes in sensitivity to strophanthin occurring during sensitization by tissue antigens].
abstract: Chronic experiments with 110 cats have shown that long-term sensitization with homocardiac antigen (HCA) causes biphasic changes in strophanthine tolerance. The increased susceptibility to strophanthine that occurs during 10 days of sensitization with HCA and depends on dissociation of the mechanisms of specific and nonspecific immunity can be prevented by simultaneous administration of diphenhydramine, methyluracil, hydrocortisone and the beta-adrenoblocker, alpheprol. This increase can be also abolished by premedication with alpheprol and trimecain.
mesh_terms: D000526:Alprenolol / Q000627:therapeutic use; D000818:Animals; D001327:Autoimmune Diseases / Q000188:drug therapy*; D002415:Cats; D004155:Diphenhydramine / Q000627:therapeutic use; D004361:Drug Tolerance; D005260:Female; D006321:Heart / Q000187:drug effects*; D006854:Hydrocortisone / Q000627:therapeutic use; D006967:Hypersensitivity / Q000188:drug therapy*; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D009206:Myocardium / Q000276:immunology*; D013328:Strophanthins / Q000494:pharmacology*; D014288:Trimecaine / Q000627:therapeutic use; D014498:Uracil / Q000031:analogs & derivatives / Q000627:therapeutic use
chemical_list: D007166:Immunosuppressive Agents; D013328:Strophanthins; D014498:Uracil; C008378:6-methyluracil; D000526:Alprenolol; D004155:Diphenhydramine; D014288:Trimecaine; D006854:Hydrocortisone
vernacular_title: Farmakoprofilaktika izmeneniĭ chuvstvitel'nosti k strofantinu, voznikaiushchikh pod vliianiem sensibilizatsii tkanevymi antigenami.