In vitro generation from murine brow marrow cells of accessory cells with discrete antigen presentation capacity and ability to release lymphostimulatory molecules.
An investigation of the immunological accessory cell function of in vitro bone marrow derived colony forming cells has been made. Data are presented to show that such cells can present immunogenic stimuli to lymphocytes and release lymphostimulatory products that in turn replace certain macrophage functions in the immune response. The appearance of these two activities is not correlated. Considerable heterogeneity exists in terms of the ability of different populations of cells to present distinct carbohydrate antigens in immunogenic form. In addition, that different macrophage cell populations can alter the affinity of antibody produced by an optimally stimulated primed spleen cell population is reported.
D000818:Animals; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology*; D001853:Bone Marrow / Q000276:immunology; D001854:Bone Marrow Cells; D002478:Cells, Cultured; D004912:Erythrocytes / Q000276:immunology; D066298:In Vitro Techniques; D008214:Lymphocytes / Q000502:physiology*; D008297:Male; D051379:Mice; D012756:Sheep / Q000276:immunology; D013154:Spleen / Q000166:cytology / Q000276:immunology
D000941:Antigens