Pregnancy block elicited by male urinary peptides in mice.
After fractionation of the urine of male mice on Sephadex G-75 followed by thin-layer electrophoresis pheromonal activity (i.e. pregnancy blocking) was found in the peptide fraction. The pregnancy-blocking pheromone is therefore a peptide or a substance bound with the peptide fraction.
D000818:Animals; D001681:Biological Assay; D002850:Chromatography, Gel; D004586:Electrophoresis; D010064:Embryo Implantation / Q000187:drug effects; D005260:Female; D008297:Male; D051379:Mice; D010455:Peptides / Q000494:pharmacology / Q000652:urine*; D010675:Pheromones / Q000494:pharmacology / Q000652:urine*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects
D010455:Peptides; D010675:Pheromones