[Prenatal carcinogenic action of 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) in the offspring of BD IX rats (author's transl)].
A single dose of 25--100 mg/kg 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (DTIC) given to BD IX rats at the end of pregnancy gave rise to the development of 10 malignant tumors in 9 out of 39 offspring. The majority of malignomas (6 of 10) were neurogenic tumors (malignant neurinomas).
D000818:Animals; D002273:Carcinogens; D003606:Dacarbazine; D005260:Female; D005333:Fetus; D009463:Neuroma / Q000139:chemically induced*; D011247:Pregnancy; D051381:Rats; D011919:Rats, Inbred Strains
D002273:Carcinogens; D003606:Dacarbazine
Pränatal karzinogene Wirkung von 5-(3,3-Dimethyl-1-triazeno)-imidazol-4-carboxamid (DTIC) bei den Nachkommen von BD IX Ratten.