[Evaluation of the potential cardiotoxicity of propranolol-lithium gluconate association (author's transl)].
The association B blocking agent-lithium salt is used for the therapy of some severe hyperthyroidism with cardiotoxicosis. Separately, both drugs depress intracardiac conduction. However by recording the potentials of the His bundle in anesthetized dogs, a potential cardiotoxicity of this association is unlikely since sinusal automaticity alone is importantly slowed. But, these results need further confirmation in man.
D000818:Animals; D004285:Dogs; D004338:Drug Combinations; D006329:Heart Conduction System / Q000187:drug effects; D006331:Heart Diseases / Q000139:chemically induced*; D006339:Heart Rate / Q000187:drug effects; D008094:Lithium / Q000633:toxicity*; D008297:Male; D011433:Propranolol / Q000633:toxicity*
D004338:Drug Combinations; D008094:Lithium; D011433:Propranolol
Association propranolol-gluconate de lithium et conduction cardiaque. Evaluation expérimentale d'un effect dépresseur éventuel.