[Cholinesterase profile of geriatric patients with reference to pathologically lowered serum cholinesterase].
1. Analysing systematically 416 geriatric patients with a predominance of heart's and circulations's disease and disturbance of mobility we find a pathological lowered cholinesterase in 36% of the cases. This percentage is higher than expected in regard to the hepatological diagnosis. 2. Analysing the histological data of 26 patients with pathological lowered cholinesterase we find with all of them a granular edema of the hepatocyt cytoplasme and intracellular lipofiscin deposit near the central veins. We find also often a diabetic and fat liver. The pathological lowered cholinesterase goes hand in hand with a pathological histology. 3. There is no correlation between the cholinesterase and the other liver enzymes. 4. These results may be interpretated as a sign for a lowered synthesis efficiency of pathological hepatocyts and there are discussed the consequences for the adaptation of the metabolism. A correlation of the years of age corresponding to the theory of deficit in age is not proved.
D000328:Adult; D000368:Aged; D002318:Cardiovascular Diseases / Q000097:blood / Q000201:enzymology; D002802:Cholinesterases / Q000097:blood*; D005260:Female; D006801:Humans; D008099:Liver / Q000201:enzymology* / Q000378:metabolism / Q000473:pathology; D008297:Male; D008875:Middle Aged
D002802:Cholinesterases
Das Cholinesteraseprofil bei geriatrischen Patienten unter Berücksichtigung der pathologisch erniedrigten Serumcholinesterase.