[Risk study of the embryotoxic and teratogenic action of the vulcanizing accelerant, Altax].
The antenatal effect of a Altax in doses 100 and 10 mg/kg was studied on two experimental animal species - rats and mice. Testing data showed that the compound has embryotoxic and teratogenic activity in dosex 100 mg/kg. The effect depended upon the time when the toxic agent was administered in the course of embryogenesis. Embryotoxic effect was recorded only in rats, teratogenic - in both animal species, being more marked in mouse embryos. The intrauterine activity of Altax in rats was accompanied by induction of anomalous morphogenesis: hydrocephalus, intracerebral hematomas, disturbances in cranial bone ossification. The teratogenic action of the Altax in mice was characterized by the appearance of external malformations: exencephaly, hypognatism, edema and anomalies of the internal organs - microphthalmia and hydrocephalus. The periods of late organogenesis and fetal development in rats are critical for the embryotoxic action of Altax, whereas the preimplantation stages and early organogenesis are sensitive for its teratogenic activity. Altax in dose of 10 mg/kg has no embryotoxic effect.
D000818:Animals; D052160:Benzothiazoles; D010064:Embryo Implantation / Q000187:drug effects; D004622:Embryo, Mammalian / Q000187:drug effects*; D047108:Embryonic Development / Q000187:drug effects; D005260:Female; D051379:Mice; D008815:Mice, Inbred Strains; D009024:Morphogenesis / Q000187:drug effects; D011247:Pregnancy; D051381:Rats; D012306:Risk; D013723:Teratogens; D013844:Thiazoles / Q000633:toxicity*
D052160:Benzothiazoles; D013723:Teratogens; D013844:Thiazoles; C028000:dibenzothiazyl disulfide
Prouchvane na riska ot embriotoksichno i teratogenno deĭstvie na vulkanizatsionniia uskoritel altaks.