[Effect of polyethylene oxide 400 on the mitotic regimen of human peripheral blood leukocytes in culture].
The effect of different concentrations of cryoprotectant polyethylene oxide (PEO-400) on the mitotic activity of human peripheral blood leucocytes was found to decrease the mitotic activity with a simultaneous increase in the metaphase number as the concentrations of PEO-400 grew. These changes were due to the general mechanism of PEO-400 action associated with its dehydrating and osmotic properties.
D002478:Cells, Cultured; D003451:Cryoprotective Agents; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D008938:Mitosis / Q000187:drug effects*; D011092:Polyethylene Glycols / Q000494:pharmacology*
D003451:Cryoprotective Agents; D011092:Polyethylene Glycols
Vliianie poliétilenoksida 400 na mitoticheskiĭ rezhim leĭkotsitov perifericheskoĭ krovi cheloveka v kul'ture.