title: [Ergometric double-blind study, Isoket-spray versus placebo-spray, in patients with coronary heart disease (author's transl)].
abstract: In a double-blind study 40 patients with coronary heart disease, who all complained of typical exertion-dependent angina pectoris symptoms and showed ECG changes after work in conformity with a myocardiac hypoxia, were examined in ergometric exertion tests before as well as immediately and 60 minutes after a single dose of 3.75 mg of Isoket-spray or Placebo-spray respectively. The Isoket-spray group was compared with the placebo group, furthermore, within the Isoket-spray group, the original ergometry (without medication) and the subsequent ergometries. The ST-depression, the time until reattainment of the original electrocardiographical situation after cessation of exertion and the subjective complaints showed highly significant improvements after use of the Isoket-spray in both repeated ergometries. Rapid and long-term relief after application of Isoket-spray were thus impressively shown in this double-blind study.
mesh_terms: D000336:Aerosols; D000787:Angina Pectoris / Q000188:drug therapy*; D003327:Coronary Disease / Q000188:drug therapy*; D004311:Double-Blind Method; D004562:Electrocardiography; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion
chemical_list: D000336:Aerosols; D007548:Isosorbide Dinitrate
vernacular_title: Ergometrische Doppelblindstudie, Isoket-Spray gegen Placebo-Spray, bei einem selektierten Kollektiv von Patienten mit koronarer Herzkrankheit.