Structure of the haemagglutinin membrane glycoprotein of influenza virus at 3 A resolution.
The haemagglutinin glycoprotein of influenza virus is a trimer comprising two structurally distinct regions: a triple-stranded coiled-coil of alpha-helices extends 76 A from the membrane and a globular region of antiparallel beta-sheet, which contains the receptor binding site and the variable antigenic determinants, is positioned on top of this stem. Each subunit has an unusual loop-like topology, starting at the membrane, extending 135 A distally and folding back to enter the membrane.
D001665:Binding Sites; D002241:Carbohydrates / Q000032:analysis; D006023:Glycoproteins / Q000096:biosynthesis; D006389:Hemagglutinins, Viral; D006860:Hydrogen Bonding; D009980:Influenza A virus; D046911:Macromolecular Substances; D008565:Membrane Proteins / Q000096:biosynthesis; D011487:Protein Conformation; D014764:Viral Proteins / Q000096:biosynthesis; D014961:X-Ray Diffraction
D002241:Carbohydrates; D006023:Glycoproteins; D006389:Hemagglutinins, Viral; D046911:Macromolecular Substances; D008565:Membrane Proteins; D014764:Viral Proteins