title: Pseudomembranous colitis after whole gut irrigation with neomycin and erythromycin base.
abstract: An unprecedented fatal case of pseudomembranous colitis (PMC) is described, associated with the use of topical antibiotics (neomycin and erythromycin base) during whole gut irrigation. This case was one of a cluster of five, occurring within a period of 4 months in 1978. These observations tend to support the hypothesis that disturbances in bacterial flora give rise to PMC and furthermore that the short-term use of antibiotics does not prevent the occurrence of PMC.
mesh_terms: D003106:Colon / Q000000981:diagnostic imaging; D004761:Enterocolitis, Pseudomembranous / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000473:pathology; D004917:Erythromycin / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009355:Neomycin / Q000009:adverse effects*; D011859:Radiography; D007507:Therapeutic Irrigation / Q000009:adverse effects*
chemical_list: D004917:Erythromycin; D009355:Neomycin