Elevated bone phosphorus/hydroxyproline ratio following jejunoileal bypass surgery.
The degree of bone mineralization, estimated as the bone phosphorus/hydroxyproline ratio (P/Hypro), was studied in 33 patients who had undergone jejunoileal bypass surgery for massive obesity. Low values of bone P/Hypro are expected in osteomalacia. We found an elevated mean bone P/Hypro (p < 0.001) with the highest values in patients with the longest postoperative periods (rS = 0.65, p < 0.001). The study indicates that bypass surgery, in spite of vitamin D deficiency, is associated with an increased average degree of bone mineralization or a defect in bone collagen synthesis.
D000328:Adult; D001842:Bone and Bones / Q000032:analysis*; D006801:Humans; D006909:Hydroxyproline / Q000032:analysis*; D007082:Ileum / Q000601:surgery*; D007583:Jejunum / Q000601:surgery*; D008875:Middle Aged; D009765:Obesity / Q000628:therapy*; D010018:Osteomalacia / Q000209:etiology; D010758:Phosphorus / Q000032:analysis*; D011183:Postoperative Complications / Q000209:etiology; D014808:Vitamin D Deficiency / Q000209:etiology
D010758:Phosphorus; D006909:Hydroxyproline