Effects of halogenated benzenes on arylesterase activity in vivo and in vitro.
Hepatic arylesterase activity was induced by 1,2,4-trichlorobenzene, hexachlorobenzene, 1,2,4-tribromobenzene, and 1,3,5-tribromobenzene but not by 1,3,5-trichlorobenzene or hexabromobenzene. Serum arylesterase was not induced by any of the halogenated benzenes and was inhibited in vivo by 1,2,4-trichlorobenzene, hexachlorobenzene, and 1,3,5-tribromobenzene. It was also inhibited in vitro.
D000818:Animals; D001555:Benzene Derivatives / Q000494:pharmacology*; D004790:Enzyme Induction / Q000187:drug effects; D004950:Esterases / Q000378:metabolism*; D005260:Female; D006846:Hydrocarbons, Halogenated / Q000494:pharmacology*; D066298:In Vitro Techniques; D008099:Liver / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology; D010648:Phenylacetates / Q000378:metabolism; D051381:Rats
D001555:Benzene Derivatives; D006846:Hydrocarbons, Halogenated; D010648:Phenylacetates; D004950:Esterases; D010634:Phenobarbital