Oxygen dependence of CCl4-induced lipid peroxidation in vitro and in vivo.
Rat liver microsomes showed an atypical oxygen dependence of carbon tetrachloride (CCL4)-induced malondialdehyde formation with a maximum at ca. 7% O2 and a minimum at ca. 15% O2. Rats treated with CCl4 expired less ethane under high oxygen concentrations and more ethane under low oxygen concentrations. The initiation of CCl4-induced lipid peroxidation in the liver would appear to be influenced by the oxygen concentrations present in the hepatocytes.
D000818:Animals; D002251:Carbon Tetrachloride / Q000633:toxicity*; D004980:Ethane / Q000378:metabolism; D050356:Lipid Metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects*; D010100:Oxygen / Q000378:metabolism*; D051381:Rats
D008315:Malondialdehyde; D002251:Carbon Tetrachloride; D004980:Ethane; D010100:Oxygen