title: [Mechanism of action of butylhydroxyanisole (BHA) toxicity: in vivo and in vitro effects on mammalian smooth muscle].
abstract: The toxicity of butylated hydroxyanisole (BHA) was greatly enhanced in the rat after i.p. administration, the LD50 being two orders of magnitude higher than the oral administered dose. The compound was shown either "in vitro" or "in vivo" to impair the smooth muscle contractility. Study on the mechanism of toxic action of Butylated hydroxyanisole (BHA): "in vivo" and "in vitro" effects on mammalian smooth muscle.
mesh_terms: D000818:Animals; D000840:Anisoles / Q000633:toxicity*; D002083:Butylated Hydroxyanisole / Q000008:administration & dosage / Q000633:toxicity*; D006801:Humans; D066298:In Vitro Techniques; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D051381:Rats
chemical_list: D000840:Anisoles; D002083:Butylated Hydroxyanisole
vernacular_title: Studio sui meccanismi dell'azione tossica del butil-idrossi-anisolo (BHA): effetti "in vivo" e "in vitro" sul muscolo liscio di mammifero.