Disordered esophageal motility in Wilson's disease.
We describe the manometric findings in a patient with hepatolenticular degeneration (Wilson's disease). After 21 years of penicillamine therapy, one of the principal neurological problems remaining in a 49-year-old white man with Wilson's disease is food-induced dysphagia. Barium contrast studies showed gross incoordination of the upper esophagus; the manometric study revealed dysmotility of the mid and distal esophagus.
D003680:Deglutition Disorders / Q000209:etiology*; D004947:Esophagus / Q000503:physiopathology*; D005769:Gastrointestinal Motility; D006527:Hepatolenticular Degeneration / Q000175:diagnosis / Q000503:physiopathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000503:physiopathology; D010528:Peristalsis