title: Regional blood flow and the localization of lymphoblasts in the small intestine of the mouse. II. The effects of a primary enteric infection with Trichinella spiralis.
abstract: The localization of 125I-UdR-labelled mesenteric lymph node cells in the small intestine and the fraction of the cardiac output delivered to this organ in mice has been examined. Concurrent measurements of these two phenomena in normal animals showed that there was a significant correlation between the localization of lymphoblasts and the distribution of regional blood flow along the small intestine. In mice undergoing enteric infection with Trichinella spiralis, however, the nature of the connection between lymphoblast localization and blood flow distribution in the small intestine was altered. More lymphoblast label accumulated in the small intestine of infected mice than in uninfected animals even at stages of the infection when no alteration in the proportion of the cardiac output received by the small intestine had occurred. Enhanced lymphoblast accumulation occurred in different segments of the infected small intestine as the infection proceeded and these changes paralleled the way in which the parasite burden was distributed in the intestine. The kinetics of lymphoblast accumulation in infected and uninfected small intestine was examined under circumstances where the delivery of blood-borne labelled cells was the same. This showed that both increased entry of lymphoblasts and enhanced retention of lymphoblasts occurred in the parasitized small intestine.
mesh_terms: D000818:Animals; D002302:Cardiac Output; D002465:Cell Movement; D007411:Intestinal Diseases, Parasitic / Q000473:pathology* / Q000503:physiopathology; D007421:Intestine, Small / Q000098:blood supply / Q000469:parasitology / Q000473:pathology*; D007958:Leukocyte Count; D008214:Lymphocytes / Q000502:physiology*; D051379:Mice; D008815:Mice, Inbred Strains; D012039:Regional Blood Flow; D013997:Time Factors; D014234:Trichinella; D014235:Trichinellosis / Q000473:pathology* / Q000503:physiopathology