Cell-cycle properties and proliferation kinetics of late erythroid progenitors in murine bone marrow.
The cell-cycle properties of marrow CFUE were assessed in normal regenerating cell preparations. In addition, the erythropoietin sensitivity of CFUE was correlated to the cell-cycle distribution of these cells. The results suggest a coupling of erythropoietin sensitivity to the S-phase of the CFUE cell cycle in so far as CFUE in G2/M/G1 were 2 to 10 times less sensitive to the hormone. It is concluded that the CFUE cell cycle per se is not a focus for erythropoietic regulation.
D000818:Animals; D001854:Bone Marrow Cells; D002453:Cell Cycle / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004912:Erythrocytes / Q000166:cytology*; D004920:Erythropoiesis / Q000187:drug effects; D004921:Erythropoietin / Q000494:pharmacology; D005260:Female; D006918:Hydroxyurea / Q000494:pharmacology; D007700:Kinetics; D051379:Mice; D013997:Time Factors
D004921:Erythropoietin; D006918:Hydroxyurea