[Renal and hepatic toxicity studies in mice treated with sodium saccharin: breaks in single-stranded DNA].
The renal and hepatic effects of in vivo treatment with saccharin have been determined as increased DNA elutability on filter. A direct dose-damage relationship was not observed in the kidney and in the liver DNA of treated mice. Doses of 50, 100 and 200 mg/Kg seem to induce in almost all the experiments the same level of single-stranded breaks. The DNA elutability is increased in the range 130-210 % if compared with controls.
D000818:Animals; D004277:DNA, Single-Stranded / Q000032:analysis / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects*; D008099:Liver / Q000187:drug effects*; D008297:Male; D051379:Mice; D012439:Saccharin / Q000633:toxicity*; D014462:Ultrafiltration
D004277:DNA, Single-Stranded; D012439:Saccharin
Studi di tossicita' epatica e renale nel topo dopo somministrazione di saccarina sodica: interruzioni nella monoelica del DNA.