title: 2,4,5-trichlorophenoxyacetic acid causes behavioral effects in chickens at environmentally relevant doses.
abstract: Administration of the herbicide 2,4,5-trichlorophenoxyacetic acid to incubating chicken eggs alters behavior after hatching. Single doses, with no morphological effects, retard learning (lowest dose, 7 milligrams per kilogram of body weight) and increase general activity (27 milligrams per kilogram) and jumping (13 milligrams per kilogram). Day 15 of incubation is the most susceptible stage of development.
mesh_terms: D015085:2,4,5-Trichlorophenoxyacetic Acid / Q000494:pharmacology* / Q000633:toxicity; D000367:Age Factors; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002642:Chick Embryo / Q000187:drug effects; D002645:Chickens; D004193:Discrimination Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D009043:Motor Activity / Q000187:drug effects
chemical_list: D015085:2,4,5-Trichlorophenoxyacetic Acid