title: Effects of pentachlorophenol on rat liver changes induced by hexachlorobenzene, with special reference to porphyria, and alterations in mixed function oxygenases.
abstract: Hexachlorobenzene (HCB, 1000 ppm) and 500 ppm pentachlorophenol (PCP) were fed separately or in combination to female Wistar rats. A control group was provided with standard food without HCB or PCP. Subgroups of 4 rats were killed after 1, 2, 4, 6 and 8 weeks. No significant difference was found between the amounts of HCB accumulated in the livers of the HCB and HCB + PCP fed rats. Administering HCB together with PCP caused a noticeable accumulation of PCP in the liver, compared to the results after administering HCB and PCP separately. In the HCB and HCB + PCP fed groups liver weight increased continuously during the experiments. Microsomal cytochrome P-450, NADPH-cytochrome c reductase, ethoxyresorufin O-de-ethylase, aminopyrine N-demethylase, and glucuronyl transferase increased to a maximum in 2-4 weeks in HCB and HCB + PCP fed rats. Pentachlorophenol accelerates the onset of HCB porphyria, in other words it increases the total urinary porphyrin excretion and causes an earlier disturbance of the porphyrin pattern.
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D056486:Chemical and Drug Induced Liver Injury; D002722:Chlorobenzenes / Q000633:toxicity*; D002733:Chlorophenols / Q000633:toxicity*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006581:Hexachlorobenzene / Q000633:toxicity*; D008099:Liver / Q000032:analysis; D008862:Microsomes, Liver / Q000201:enzymology; D010416:Pentachlorophenol / Q000633:toxicity*; D011164:Porphyrias / Q000139:chemically induced*; D011166:Porphyrins / Q000652:urine; D051381:Rats
chemical_list: D002722:Chlorobenzenes; D002733:Chlorophenols; D011166:Porphyrins; D006581:Hexachlorobenzene; D010416:Pentachlorophenol