A simple method for ex vivo evaluation of biomaterial interaction with blood platelets.
The process of thrombus formation, as a consequence of the interaction of artificial surfaces with blood, is related to the activation of blood platelets. A simple ex vivo method, which is suitable for the evaluation of the platelet-surface interaction is described. This method has been used to compare the haemocompatibility of several artificial materials, including nylon-6, Silastic and pyrolytic carbon.
D000818:Animals; D001672:Biocompatible Materials / Q000378:metabolism*; D001792:Blood Platelets / Q000378:metabolism* / Q000648:ultrastructure; D002244:Carbon; D008297:Male; D008722:Methods; D008855:Microscopy, Electron, Scanning; D009757:Nylons; D010973:Platelet Adhesiveness; D011817:Rabbits; D012826:Silicone Elastomers; D013927:Thrombosis / Q000209:etiology
D001672:Biocompatible Materials; D009757:Nylons; D012826:Silicone Elastomers; D002244:Carbon