[Effect of 15 antineoplastic drugs on colon carcinoma growing in vitro: a screening assay for cytotoxicity (author's transl)].
The cytotoxic effects of 15 drugs used in clinical oncology have been studied on rat colon cancer cells growing in vitro. A 50 per cent cytotoxic activity was obtained with molar concentration from 1.3 10(-8) to more than 4.10(-2), according to the drug. This cheap and quick assay could be useful for screening new drugs or new drug associations to be selected for clinical trials.
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002478:Cells, Cultured; D003110:Colonic Neoplasms / Q000188:drug therapy*; D004353:Drug Evaluation, Preclinical / Q000379:methods; D009374:Neoplasms, Experimental / Q000188:drug therapy; D051381:Rats
D000970:Antineoplastic Agents
Effet de 15 drogues anticancéreuses sur un carcinome intestinal en culture: Un test de dépistage rapide de l'activité cytotoxique.