title: Significance of carbon monoxide pulmonary partial ductances and transbronchial lung biopsies during evolution of interstitial lung diseases.
abstract: Among 80 patients with suspicion of interstitial lung disease (ILD), we studied the significance of carbon monoxide (CO) partial ductances with special reference to arterio-alveolar partial ductances (DuaCO), for diagnosis and follow-up of 63 of them. The results of DuaCO were compared to histologic and radiologic data, in 40 patients with abnormal X-ray findings (interstitial lesions) and in 23 patients with normal X-ray findings. In patients with abnormal X-ray findings there is a statistical correlation between decrement of DuaCO and existence of histologic interstitial lesions (p < 0.001). In patients with normal X-ray findings but a risk of interstitial injury, there is also a statistical relation between alteration of DuaCO and existence of histologic interstitial lesions (p < 0.02). DuaCO seems to be closely linked to trophicity of the pulmonary interstitium and is proposed as a functional index to follow up ILD.
mesh_terms: D001195:Asbestosis / Q000175:diagnosis; D001706:Biopsy; D001716:Bird Fancier's Lung / Q000175:diagnosis; D001991:Bronchitis / Q000175:diagnosis; D001999:Bronchoscopy; D002248:Carbon Monoxide; D006801:Humans; D008168:Lung / Q000473:pathology*; D008171:Lung Diseases / Q000175:diagnosis* / Q000473:pathology; D011653:Pulmonary Diffusing Capacity; D012507:Sarcoidosis / Q000175:diagnosis; D012806:Siderosis / Q000175:diagnosis
chemical_list: D002248:Carbon Monoxide