title: Ultrastructure of one Ewing's sarcoma of bone with endothelial character and a comparative review of the vessels in 27 cases of typical Ewing's sarcoma.
abstract: An atypical variant of Ewing's sarcoma, located in the left hip of a nine-year-old girl, is discussed at optical, histochemical and electron microscopical level. The endothelial appearing cells seem to play a main role in its histogenesis. Tumoral cells of an undifferentiated blastemic nature show round nuclei and bright lucent cytoplasm, being organized in solid sheets or vascular-like profiles. Alkaline and acid phosphatases are very prominent in all tumoral cells, and some of them also show PAS positive material. Its ultrastructure demonstrates an active pinocytic capacity, cytoplasmic filaments and Weibel-Palade bodies. Simultaneously a review is performed on 27 cases of typical Ewing's sarcoma of bone in order to compare its vessels of a reactive nature with this tumor. A differential diagnosis with hemangioendothelioma primary to bone is established.
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D000469:Alkaline Phosphatase / Q000032:analysis; D001808:Blood Vessels / Q000648:ultrastructure*; D001859:Bone Neoplasms / Q000201:enzymology / Q000648:ultrastructure*; D002648:Child; D004727:Endothelium / Q000648:ultrastructure*; D005260:Female; D006615:Hip; D006801:Humans; D008854:Microscopy, Electron; D010873:Pinocytosis; D012512:Sarcoma, Ewing / Q000201:enzymology / Q000648:ultrastructure*
chemical_list: D000469:Alkaline Phosphatase; D000135:Acid Phosphatase