[Effect of natural and synthetic PG on movement and phagocytosis of human leukocytes].
PGE1 and its 8-aza-analogous were assayed "in vitro" for leukocyte functions; the natural compound was not a chemotactic agent and exhibited positive chemokinesis. On the contrary, the synthetic compound chemically related to PGE1, was a chemotactic factor and inhibited the reduction of NBT during phagocytosis.
D000527:Alprostadil / Q000031:analogs & derivatives*; D002630:Chemotactic Factors; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D006098:Granulocytes / Q000187:drug effects; D006801:Humans; D009504:Neutrophils / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects*; D011458:Prostaglandins E / Q000494:pharmacology*; D011459:Prostaglandins E, Synthetic / Q000494:pharmacology*
C028327:8-azaprostaglandin E1; D002630:Chemotactic Factors; D011458:Prostaglandins E; D011459:Prostaglandins E, Synthetic; D000527:Alprostadil
Effetto di PG naturale e di sintesi sul movimento e fagocitosi dei leucociti umani.