Effect of oxymetholone on human cyclic haematopoiesis.
A 62-year-old woman had recurrent fluctuations of neutrophil, monocyte, reticulocyte and platelet counts with a cycling time of 38.5 d. Periodic fluctuations of granulo-, erythro- and megakaryopoiesis were also demonstrated in her bone-marrow. Oxymetholone reduced the magnitude of the profound cyclic fluctuations in all these cell lines. During treatment a reduced number of in vitro CFU-C of the progenitor myeloid series from the bone marrow was observed. Using the patient leucocytes as feeders for normal control marrow cells, indication was found for a fluctuation in colony stimulating activity in vitro, rising above normal at the nadir of the WBC.
D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D003114:Colony-Forming Units Assay; D005260:Female; D006402:Hematologic Diseases / Q000097:blood / Q000473:pathology; D006410:Hematopoiesis; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D009196:Myeloproliferative Disorders / Q000188:drug therapy*; D010110:Oxymetholone / Q000627:therapeutic use*; D010507:Periodicity; D013997:Time Factors
D006454:Hemoglobins; D010110:Oxymetholone