Study on segregation and risk for abnormal offspring in carriers of pericentric inversion of the (p11 leads to q13) segment of chromosome 2.
Pericentric inversion of chromosome 2 was detected in four unrelated families. All these inversions involved the segment p11 leads to q13. The pedigree data are considered in comparison with other cases reported in the literature. Segregation data and possible reproductive failures are discussed.
D000015:Abnormalities, Multiple / Q000235:genetics; D002648:Child; D007446:Chromosome Inversion; D002900:Chromosomes, Human, 1-3; D006579:Heterozygote; D006801:Humans; D007223:Infant; D008297:Male; D010375:Pedigree; D012306:Risk