Inhibition of experimental esophageal lye strictures by penicillamine.
We describe a new experimental model for the study of caustic stenosis of the esophagus in the rat. Sixty-five Wistar rats were given a standard esophageal lye burn. Animals were divided into two groups: (1) a control group and (2) a treatment group that received penicillamine from the day after the esophageal lye burn. Stenosis developed in only two of the 23 treated rats. Our conclusion is that penicillamine-induced lathyrism inhibits the onset of stenosis in the rat. Double-blind controlled studies of the effect of penicillamine in the prevention of corrosive strictures of the esophagus in man seem warranted.
D000818:Animals; D002057:Burns, Chemical / Q000517:prevention & control*; D002424:Caustics / Q000009:adverse effects*; D004195:Disease Models, Animal; D004940:Esophageal Stenosis / Q000139:chemically induced / Q000517:prevention & control*; D007842:Lathyrism / Q000139:chemically induced*; D008191:Lye / Q000009:adverse effects*; D010396:Penicillamine / Q000627:therapeutic use; D051381:Rats
D002424:Caustics; D008191:Lye; D010396:Penicillamine