Failure to obtain an autoimmune response following cryosurgery to the normal rat liver.
Smooth muscle antibody (SMA) and anti-liver-specific lipoprotein (anti-LSP) responses were investigated following five different freeze thaw regimes to the normal rat liver. The livers were examined histologically for evidence of autoimmune liver disease. No SMA or anti-LSP was found in any animal and on histological examination the unfrozen part of all livers was normal. It is concluded that cryosurgical damage to the liver is unlikely to provoke an autoimmune response.
D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis*; D001327:Autoimmune Diseases / Q000473:pathology; D003452:Cryosurgery; D008074:Lipoproteins / Q000276:immunology; D008099:Liver / Q000276:immunology / Q000473:pathology / Q000601:surgery*; D008107:Liver Diseases / Q000473:pathology; D008297:Male; D009130:Muscle, Smooth / Q000276:immunology; D051381:Rats
D001323:Autoantibodies; D008074:Lipoproteins