title: Effects of antituberculosis and antileprosy drugs on mycobacteriophage D29 growth.
abstract: The minimal inhibitory concentrations of antituberculosis and antileprosy drugs were determined for Mycobacterium aurum. The concentrations that reduced the final yield of bacteriophage D29R1 by 50% and the time during the replication cycle at which the drugs completely inhibited phage production were estimated. THe 50% inhibitory concentration/minimal inhibitory concentration ratios were close to 1.0 for clofazimine, colistin, rifampin, and streptomycin; these ratios were high for dapsone (diaminodiphenylsulfone) and isoniazid. Ethambutol (minimal inhibitory concentration, 1.0 micrograms/ml) was without effect on viral growth.
mesh_terms: D000995:Antitubercular Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D007917:Leprostatic Agents / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009160:Mycobacteriophages / Q000187:drug effects* / Q000254:growth & development; D009161:Mycobacterium / Q000187:drug effects
chemical_list: D000995:Antitubercular Agents; D000998:Antiviral Agents; D007917:Leprostatic Agents