title: Dosage of acetylsalicylic acid for inhibition of platelet function.
abstract: In normal males, platelet prostaglandin synthesis as measured by malondialdehyde (MDA) production is blocked by more than 90% after administration of 600 mg of calciumacetylsalicylic acid and by more than 50% after 100 mg. Repeated doses of 100 mg at 12 h intervals progressively decrease MDA production to below 10% of the basic value. Bleeding time increases from 3.38 +/- 0.36 min to 7.73 0.91 min (mean +/- SEM). The data indicate that 12 h 100 mg doses of calciumacetylsalicylic acid (equal to 80 mg of aspirin) adequately inhibit platelet function.
mesh_terms: D001241:Aspirin / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D001760:Bleeding Time; D001792:Blood Platelets / Q000187:drug effects* / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D008315:Malondialdehyde / Q000096:biosynthesis; D011453:Prostaglandins / Q000096:biosynthesis* / Q000097:blood; D013917:Thrombin
chemical_list: D011453:Prostaglandins; D008315:Malondialdehyde; D013917:Thrombin; D001241:Aspirin