Reversal of histopathologic pulmonary changes with indomethacin.
There are pulmonary changes documented by light and electron microscopy in a canine model of nonhypotensive shock induced by a lower limb tourniquet. These histopathologic changes are mediated, at least in part, when the dog is treated with indomethacin.
D000818:Animals; D001784:Blood Gas Analysis; D004285:Dogs; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology*; D007869:Leg Injuries; D008168:Lung / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008854:Microscopy, Electron; D012128:Respiratory Distress Syndrome / Q000473:pathology* / Q000517:prevention & control; D014111:Tourniquets
D007213:Indomethacin