Use of glycopyrrolate in the parturient: effect on the maternal and fetal heart and uterine activity.
The effects of intravenous glycopyrrolate on maternal and fetal heart rate, heart rate variability, and maternal electromechanical intervals and blood pressure were evaluated in 20 term parturients in labor. Direct continuous fetal heart rate and intrauterine pressure were monitored via an intrauterine catheter. Maternal heart rate and R-pulse-wave intervals were measured and maternal blood pressure was recorded at 5-minute intervals. There were no significant changes in fetal heart rate or fetal heart rate variability. The maternal heart rate increased in all cases and the electromechanical interval decreased with the onset of maternal tachycardia. There were no significant changes in maternal blood pressure. Uterine activity increased in all cases; however, this increase does not appear to be greater than that expected in uterine activity as labor progresses.
D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D005318:Fetal Heart / Q000187:drug effects*; D006024:Glycopyrrolate / Q000008:administration & dosage / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D007263:Infusions, Parenteral; D007743:Labor, Obstetric; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011674:Pulse / Q000187:drug effects; D011759:Pyrrolidines / Q000494:pharmacology*
D011759:Pyrrolidines; D006024:Glycopyrrolate