title: [Effect of aligeron and cinnarizine on the behavior of experimental animals].
abstract: The following methods were used: neuropharmacologic study according to the a modified method of Nikolova, Daleva, orientation reaction according to Boissier and Simon, "open field" according to Fontenay et al. and actographic study. The data from "the free" observation suggested clearly a manifested central stimulating effect of aligeron. The data from the actographic study were similar, which showed an increased motor activity in mice and rats, given doses of 1/100-1/4 of LD50. The stimulating action of the preparation was observed in doses of 1/8-1/6 of LD50 during the experimental procedure "open field". The preparation inhibited orientation reaction in mice. Cinnarizine inhibited the examined indices, obtained by all tests. The complex of the used methods allowed to make an inference that aligeron had central stimulating effect, weaker in smaller therapeutic doses and more manifested in higher doses. Cinnarizine had weak depressive effect.
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002936:Cinnarizine / Q000031:analogs & derivatives / Q000494:pharmacology*; D002940:Circadian Rhythm / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D051379:Mice; D009043:Motor Activity / Q000187:drug effects; D009949:Orientation / Q000187:drug effects; D010879:Piperazines / Q000494:pharmacology*; D051381:Rats
chemical_list: D010879:Piperazines; D002936:Cinnarizine; C021591:Aligeron
vernacular_title: Vliianie na aligeron i tsinarizin vûrkhu povedenieto a eksperimentalni zhivotni.