title: Epidural opiate and perioperative analgesia.
abstract: Epidural injections of 5 mg nicomorphine in 20 ml 5% glucose wee given to 10 gynaecological patients to provide intra-operative and post-operative analgesia. Signs of changed nociception appeared within 5 min. The maximum change occurred within 20 min. Effectiveness was at least 3 1/2 h. After an observation period of 30 min, light general anaesthesia is supplemented to give excellent operating conditions. It is suggested that opiates produce these effects by a direct action on the endorphin "pain" modulatory system of human beings at spinal level.
mesh_terms: D000328:Adult; D000368:Aged; D000698:Analgesia; D001794:Blood Pressure / Q000187:drug effects; D004388:Dura Mater; D005260:Female; D006801:Humans; D007267:Injections; D007431:Intraoperative Complications / Q000517:prevention & control; D008297:Male; D008875:Middle Aged; D009294:Narcotics / Q000008:administration & dosage*; D010149:Postoperative Pain / Q000517:prevention & control; D011292:Premedication; D011674:Pulse / Q000187:drug effects; D012119:Respiration / Q000187:drug effects; D013514:Surgical Procedures, Operative
chemical_list: D009294:Narcotics