Vasomotor origin of intracranial pressure waves in hydrocephalic infants.
By measuring cerebral blood volume (CBV) and intracranial pressure (ICP) variations at the same running time during sleep, it has been demonstrated that the ICP wave which appears during the REM sleep in hydrocephalic infants is produced by intracerebral vaso-dilatation. Nine infants with stabilized hydrocephalus were investigated by non-invasive means: REM phases were distinguished with the usual polysomnographic electrodes. Intracranial pressure was measured with a fontanel palpation transducer and CBV variations were obtained by recording 99mTc activity at the head level after in vivo labelling of red cells with 99mTc--pertechnetate. The time-activity curves, obtained from regions of interest and selected on the sequential radioisotope images, show that an increased ICP wave, occurring during the REM period, is related to a simultaneous increase in the blood volume, limited to the cerebral sector and not to the area of the external carotid artery.
D001810:Blood Volume; D002560:Cerebrovascular Circulation; D006801:Humans; D006849:Hydrocephalus / Q000503:physiopathology*; D007223:Infant; D007231:Infant, Newborn; D007427:Intracranial Pressure; D012895:Sleep, REM / Q000502:physiology; D013667:Technetium; D014666:Vasomotor System / Q000503:physiopathology*
D013667:Technetium