Synthesis and pharmacological activity of three new 9-aryl-8-azaadenine derivatives.
This paper describes the synthesis of three new 9-aryl-8-azaadenine derivatives (Ic, d, e) and of some related compounds, using the appropriate 1-substituted-5-amino triazoles (IV) as starting material. The new azaadenines were subjected to pharmacological screening and the carboxylic compound (I c) showed an interesting antiallergic activity, depending on the presence of the free acid function.
D000225:Adenine / Q000031:analogs & derivatives* / Q000138:chemical synthesis; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D000225:Adenine