[The influence of radio- and chemotherapy on DNA repair of peripheral lymphocytes of tumor patients (author's transl)].
The influence of radiotherapy in 10 patients and chemotherapy in 5 patients, on DNA excision repair capacity was investigated in lymphocytes of the peripheral blood. No effects on DNA repair were found using only betatrone of 60Co-irradiation under normal conditions. Combination of both irradiation schedules over a longer period of therapy provoked an inhibition of DNA repair. Chemotherapy inhibits DNA repair immediately after starting therapy, but after a relatively short time, the extent of DNA repair increases above normal level.
D000328:Adult; D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D001943:Breast Neoplasms / Q000532:radiotherapy*; D001984:Bronchial Neoplasms / Q000532:radiotherapy*; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects*; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000532:radiotherapy*; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects*; D008297:Male; D008875:Middle Aged; D011867:Radioisotope Teletherapy; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy*; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy*
D000970:Antineoplastic Agents
Uber den Einfluss zytostatischer Chemotherapie und perkutaner Strahlentherapie auf die DNA-Reparatur peripherer Lymphozyten von Tumorpatienten.