Synthesis and pharmacological activity of some 9-aryl-8-azapurine derivatives.
Because of the biological interest of 8-azaanologous of purine bases, the preparation of some 8-azapurines (IV) and (V), substituted in 9 position with aryl groups, is described. Compounds were obtained by closure of a pyrimidine nucleus on performed 5-amino-1,2,3-triazole derivatives. Some substances, subjected to pharmacological screening, showed an interesting antiallergic activity.
D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D051379:Mice; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D011687:Purines / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D011687:Purines; C015008:triazolopyrimidinone