Toxaphene residues in the bovine after oral exposure.
Toxaphene was administered orally to 19 mixed-breed heifers at levels of 50, 100, or 150 mg/kg. Thirteen of 19 died with deaths in all 3 dosage levels. Liver, kidney, and brain samples were collected and analyzed for toxaphene residues by GLC. Liver residues varied logarithmically with dosage from 1.2 to 38 ppm, kidney residues were from 0.8 to 12 ppm, and brain residues were from 0.3 to 7.0 ppm. No detectable amounts of toxaphene (< 0.1 ppm) were observed in tissues collected from 2 control calves which received no toxaphene.
D000284:Administration, Oral; D000818:Animals; D002417:Cattle / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007306:Insecticides / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D014018:Tissue Distribution; D014112:Toxaphene / Q000378:metabolism* / Q000633:toxicity
D007306:Insecticides; D014112:Toxaphene