[Effect of cholestyramine and chenodesoxycholic acid on liver cirrhosis. An experimental study in rats].
The influence of cholestyramine and chenodeoxycholic acid on the induction of cirrhosis of the liver of the male Wistar strain rats was studied. The simultaneous dietary exposure of 1 g cholestyramine in 100 g diet prevented the development of cirrhosis induced by carbon tetrachloride. Whereas all the animals in the control group (CCl4-Exposure plus normal diet) developed cirrhosis, histologic examination showed cirrhosis in only 2 of 9 rats fed with diet containing cholestyramine. On the contrary, the exposure to chenodeoxycholic acid at a concentration of 1 g in 300 g diet potentiated the induction of cirrhosis. The experimental results support the clinical findings in which the administration of cholestyramine caused an improvement of liver function tests by cirrhosis.
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000517:prevention & control; D002635:Chenodeoxycholic Acid / Q000009:adverse effects* / Q000494:pharmacology; D002792:Cholestyramine Resin / Q000494:pharmacology*; D004357:Drug Synergism; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008111:Liver Function Tests; D008297:Male; D051381:Rats
D002635:Chenodeoxycholic Acid; D002792:Cholestyramine Resin
Einfluss von Cholestyramin und Chenodesxycholsäure auf die Leberzirrhose--Experimentelle Studie mit Ratten.