Study on drug interactions.
Studies on the interactions of the drugs used in combination therapy of leprosy were attempted at this Institute. INH supplementation with clofazimine, therapy appeared to lower the skin levels of clofazimine, raising the plasma and urinary content of clofazimine. Concurrent administration of clofazimine with DDS does not appear to exert any influence on the excretion of DDS. The plasma DDS lowering effect of Rifampicin does not vary between fast and slow acetylators for DDS.
D000328:Adult; D002991:Clofazimine / Q000008:administration & dosage / Q000378:metabolism*; D003622:Dapsone / Q000008:administration & dosage / Q000378:metabolism*; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage*; D007918:Leprosy / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D012293:Rifampin / Q000008:administration & dosage / Q000494:pharmacology
D003622:Dapsone; D002991:Clofazimine; D007538:Isoniazid; D012293:Rifampin