Effect of alpha, alpha, alpha-trifluoro-2-methyl-4'-nitro-m-lactotoluidide (Sch 16423) on serum testosterone and LH in rats.
Administration of Sch 16423 to intact male rats (5 mg/day s.c. for 7 days) resulted in a rapid and dramatic rise in the serum concentrations of LH and testosterone. This suggests that this metabolite of flutamide is the active antiandrogenic agent.
D000726:Androgen Antagonists / Q000494:pharmacology*; D000813:Anilides / Q000494:pharmacology*; D000818:Animals; D005485:Flutamide / Q000031:analogs & derivatives / Q000494:pharmacology*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D051381:Rats; D013739:Testosterone / Q000097:blood*
D000726:Androgen Antagonists; D000813:Anilides; C014290:hydroxyflutamide; D013739:Testosterone; D005485:Flutamide; D007986:Luteinizing Hormone