Sudden blindness in acute pancreatitis. Possible role of complement-induced retinal leukoembolization.
During an episode of acute alcoholic pancreatitis, severe visual loss and the funduscopic appearance of Purtscher's retinopathy-a syndrome thought to be caused by posterior retinal microembolization-developed in a patient. We propose that emboli in this case may have consisted of aggregated granulocytes since plasma samples from eight to 12 patients with subsequently studied acute pancreatitis caused granulocyte aggregation in vitro. The aggregant was demonstrated to be an activated fragment of the complement system, derived from C5. Since we could generate identical granulocyte aggregating activity by treating serum or purified C5 with trypsin, we suggest that proteases released from an inflamed pancreas might have produced a C5-derived aggregant in this case, as well as in three other previously reported cases of acute pancreatitis and Purtscher's retinopathy. We conclude that complement-induced leukoembolization may be a previously unsuspected cause of vital-tissue damage.
D000208:Acute Disease; D000328:Adult; D001766:Blindness / Q000150:complications*; D002449:Cell Aggregation; D003182:Complement C5 / Q000502:physiology; D004617:Embolism / Q000150:complications / Q000473:pathology; D006098:Granulocytes / Q000502:physiology; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000150:complications* / Q000473:pathology; D012160:Retina / Q000473:pathology*; D012166:Retinal Hemorrhage / Q000150:complications / Q000473:pathology; D013577:Syndrome
D003182:Complement C5