title: The influence of food on the absorption of diclofenac after single and multiple oral doses.
abstract: A single dose of enteric-coated diclofenac sodium was taken fasting and immediately after a standard breakfast by twelve healthy volunteers. A considerable delay in the onset of absorption was observed, non-fasting, varying from 2.5 to 12 h compared with 1.5 to 2.75 h when fasting. Peak plasma concentrations were reduced after food but areas under plasma concentration-time curves were comparable. Six subjects then took part in a study involving single and repeated dosing under fasting and non-fasting conditions. As before, prolonged and variable delays were observed when the enteric-coated tablets were taken after food. On repeated dosing, maximum plasma concentrations were reached after 6 h non-fasting compared with 2.5 h fasting. Peak plasma levels were, however, similar.
mesh_terms: D000042:Absorption; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D004008:Diclofenac / Q000008:administration & dosage / Q000378:metabolism*; D005215:Fasting; D005260:Female; D005502:Food; D006801:Humans; D008297:Male; D010648:Phenylacetates / Q000378:metabolism*; D013608:Tablets, Enteric-Coated; D013997:Time Factors
chemical_list: D010648:Phenylacetates; D013608:Tablets, Enteric-Coated; D004008:Diclofenac