Impaired monocyte-mediated cytotoxicity in atopic dermatitis.
Twenty-three adult patients with atopic dermatitis of different severity and extent all without present cutaneous infection were investigated for antibody-dependent cytotoxicity mediated by purified monocytes. Compared to a healthy control group the monocyte cytotoxicity was significantly decreased for patients with more widespread dermatitis. Eight patients with acute contact dermatitis and 13 patients with extrinsic asthma or allergic rhinitis showed normal cytotoxicity. Decreased monocyte cytotoxicity in atopic dermatitis was not related to the serum IgE level. In vitro cultivation of defective monocytes from atopics did not increase cytotoxicity, nor did normal monocytes preincubated with patient serum show abnormal function. In atopic dermatitis the total number of Fc receptor bearing monocytes was normal. However, the affinity of this receptor was lower than in normals. Serial studies are needed to establish whether reduced monocyte function is a basic pathophysiologic defect in atopic dematitis.
D000293:Adolescent; D000328:Adult; D000920:Antibody-Dependent Cell Cytotoxicity; D001249:Asthma / Q000276:immunology; D003602:Cytotoxicity, Immunologic; D003876:Dermatitis, Atopic / Q000276:immunology*; D003877:Dermatitis, Contact / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D009000:Monocytes / Q000276:immunology*; D011961:Receptors, Fc / Q000276:immunology
D011961:Receptors, Fc