Neonatal rickets. Histopathology and quantitative bone changes.
Ribs from 3 preterm infants, who had died after prolonged intravenous feeding and artificial ventilation, were examined histologically and assessed for the degree of osteomalacia and osteoporosis in cancellous bone of the shaft. A grid counting technique was used. Osteomalacia was noted in all 3 cases but to a lesser degree than in classical vitamin D-deficient controls. Osteoporosis was pronounced in the cases of neonatal rickets, but this was not a feature of the vitamin D-deficient controls. Histological features were similar to those reported in experimental phosphate-deficient rickets and vitamin D-resistant rickets.
D001842:Bone and Bones / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000473:pathology*; D010018:Osteomalacia / Q000473:pathology; D010024:Osteoporosis / Q000473:pathology; D012279:Rickets / Q000473:pathology*