[High resolution proton magnetic resonance study of a series of 9-substituted acridines: correlation with biological activities].
250 MHz 1H N.M.R. spectra of a set of 9-substituted derivatives of acridine as solutes in DMSO-d6 were studied. Because of ABCD coupling figures, magnetic parameters were determined by means of simulated spectra. Semi-empirical correlations were proposed for chemical shifts. Moreover, pi distribution in the heterocycle was investigated. Results are discussed in relation to some weak biological properties of the acridine drugs.
D000166:Acridines / Q000494:pharmacology*; D004121:Dimethyl Sulfoxide; D009682:Magnetic Resonance Spectroscopy; D013329:Structure-Activity Relationship
D000166:Acridines; D004121:Dimethyl Sulfoxide
Etude par résonance magnétique nucléaire protonique à haut champ d'une série d'acridines-9 substituées; essai de corrélation avec les activités biologiques.