Pharmacological studies on p-chlorophenylamide of 3-methyl-5-benzoylaminoizothiazole-4-carboxylic acid (compound ITCL) the preparation of eventual anti-inflammatory effect.
Pharmacological activity of p-chlorophenylamide of 3-methyl-5-benzoylaminoizothiazole-4-carboxylic acid (compound ITCl) was studied with special regard to its anti-inflammatory effect. Compound ITCl is moderately toxic with no distinct circulatory and central effect. On the other hand, it shows strong anti-inflammatory activity in many tests of immunologically specific, nonspecific and infectious inflammations. The greatest efficacy of the compound was noted in the therapy of experimental, immunologically non-specific (xylene, carrageenin and cotton-test) inflammations. Weaker and less regular therapeutic effect was noted in the cases of immunologic inflammations -- mainly in contact reaction to dinitrochlorobenzene. Compound ITCl was ineffective in relation to transplantation barrier. Therapeutic efficacy of the compound was not observed in herpetic inflammation of the skin. On the other hand, a promising therapeutic effect was noticed in relation to cow-pox virus keratitis. Compound ITCl is well tolerated. It shows no toxic effect on white and red blood cells system in a 4-week exposition. Compound ITCl stabilizes cell membranes. Practical aspect of the obtained results was discussed.
D000818:Animals; D000893:Anti-Inflammatory Agents; D002264:Carboxylic Acids / Q000633:toxicity; D002351:Carrageenan / Q000009:adverse effects; D055598:Chemical Phenomena; D002621:Chemistry; D003877:Dermatitis, Contact / Q000188:drug therapy*; D006168:Guinea Pigs; D007634:Keratitis / Q000188:drug therapy*; D051379:Mice; D011817:Rabbits; D051381:Rats; D013844:Thiazoles / Q000627:therapeutic use*; D014615:Vaccinia / Q000188:drug therapy*; D014992:Xylenes / Q000009:adverse effects
D000893:Anti-Inflammatory Agents; D002264:Carboxylic Acids; D013844:Thiazoles; D014992:Xylenes; C027999:5-(benzoylamino)-N-(4-chlorophenyl)-3-methyl-4-isothiazolecarboxamide; D002351:Carrageenan