title: Role of gram negative bacteria in ontogeny of gut immunity.
abstract: This paper describes an experiment which provides information on the ontogeny of some parameters of the intestinal immune system in normal lambs. It is also demonstrated that oral administration of a gram negative bacterial vaccine to foeta lambs resulted in non-specific amplification of the population of IgA plasma cells in the gut and its associated lymphoid tissue, suggesting involvement of bacterial lipopolysaccharide, a recognised B-lymphocyte mitogen, in ontogeny of gut immunity.
mesh_terms: D000818:Animals; D001419:Bacteria / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology; D007422:Intestines / Q000276:immunology* / Q000382:microbiology; D008070:Lipopolysaccharides / Q000276:immunology; D008198:Lymph Nodes / Q000276:immunology; D010950:Plasma Cells / Q000276:immunology; D012756:Sheep
chemical_list: D001428:Bacterial Vaccines; D008070:Lipopolysaccharides