In vitro effect of human placental lactogen on steroidogenesis in human placental tissue from early pregnancy.
Studies were carried out with human placental lactogen (hPL) to elucidate its role in regulation of steroidogenesis (progesterone and estrogens) during early pregnancy in humans. Our in vitro studies with early pregnancy placenta under different doses of hPL demonstrated that this hormone could stimulate the synthesis of progesterone as well as estrogens (estrone and estradiol) from their respective precursors.
D004967:Estrogens / Q000096:biosynthesis; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D010920:Placenta / Q000378:metabolism*; D010928:Placental Lactogen / Q000502:physiology*; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011374:Progesterone / Q000096:biosynthesis; D013256:Steroids / Q000096:biosynthesis*; D013347:Subcellular Fractions / Q000378:metabolism; D014018:Tissue Distribution
D004967:Estrogens; D013256:Steroids; D011374:Progesterone; D010928:Placental Lactogen