Early proliferative activity: its occurrence in the crypts of small bowel and colon after partial small-bowel resection.
Crypt population kinetics in both small bowel and colon were determined in the early postoperative period in the rat after either sham resection or resection of 50% of the midportion of the small bowel. A proliferative response was evident in the colon within 24 hours. This response of the labeling index was statistically significant in the left colon by comparison with the sham-resected animals, whereas in the right colon it was significant by comparison not only with the sham-resected but also with the intact animals. A proliferative response was documented in the remnants of the small bowel on the third postoperative day by comparison with those of the sham-resected animals. These findings indicate that adaptive hyperplasia begins very promptly in the intestinal remnants after partial resection.
D000818:Animals; D002455:Cell Division; D003106:Colon / Q000502:physiology* / Q000601:surgery; D007421:Intestine, Small / Q000502:physiology* / Q000601:surgery; D008297:Male; D011184:Postoperative Period; D051381:Rats