title: [Synthesis of compounds with antisecretory activity].
abstract: Some indole and pyrrolidone derivatives of two peptides, H-Ile-His-Pro-NH2 and N epsilon-Boc-Lys-Ile-His-Pro-NH2, were prepared and tested for antisecretory activity. A report is given of the synthetic scheme used for the two peptides which is a modified Jones procedure, the preparation of pyrrolidin-5-one-N-heptanoic acid and 1H-indol-3-heptanoic acid, the introduction on the peptide chain of indole and pyrrolidone radicals and the results of the pharmacological investigation.
mesh_terms: D000818:Animals; D003864:Depression, Chemical; D005750:Gastric Juice / Q000378:metabolism*; D009842:Oligopeptides / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats
chemical_list: D009842:Oligopeptides
vernacular_title: Sintesi di composti ad attività antisecretoria.