[Stimulating action of estradiol dipropionate on uterine sarcomagenesis induced by 1,2-dimethylhydrazine in mice].
CBA female mice received weekly subcutaneous injections of 1,2-dimethylhydrazine (1,2-DMH) in a dose of 8 mg/kg for 10 weeks (group 1). In groups 2,3 and 4 1,2-DMH plus estradiol dipropionate were administered for 10, 20 or 25 weeks, respectively. The incidence of uterine sarcoma in groups 1, 2, 3 and 4 was 3.3, 2.5, 65.4 and 73%, respectively. The mice given estradiol dipropionate alone developed no uterine sarcomas. Possible mechanisms of the uterine sarcomogenesis stimulation by estrogen are discussed.
D000818:Animals; D003043:Cocarcinogenesis; D004127:Dimethylhydrazines / Q000008:administration & dosage*; D004958:Estradiol / Q000008:administration & dosage*; D005260:Female; D008763:Methylhydrazines / Q000008:administration & dosage*; D051379:Mice; D008808:Mice, Inbred CBA; D012513:Sarcoma, Experimental / Q000139:chemically induced*; D013997:Time Factors; D014594:Uterine Neoplasms / Q000139:chemically induced*
D004127:Dimethylhydrazines; D008763:Methylhydrazines; D004958:Estradiol
Stimuliruiushchee deĭstvie éstradiola dipropionata na sarkomogenez matki, indutsiruemyĭ 1,2-dimetilgidrazinom u mysheĭ.