Net albumin transport across the wall of the rabbit common carotid artery perfused in situ.
We have studied the transport of radioactively labelled albumin in the rabbit common carotid artery perfused in situ at 100 cm H2O luminal pressure in the anaesthetized living animal, assessing the distribution of concentration across the wall by means of sequential frozen sectioning. We have compared the findings with those of experiments in which we have attempted to saturate the wall with label. Our findings support the belief that there is a net transport of macromolecules across the arterial wall. They show in addition that the wall is inhomogeneous. The distribution volume for label is greater in the adventitia than the media, which appears to offer a larger resistance. The transport process is seemingly dominantly diffusional.
D000818:Animals; D002339:Carotid Arteries / Q000378:metabolism*; D005260:Female; D066298:In Vitro Techniques; D008297:Male; D010477:Perfusion; D011506:Proteins / Q000378:metabolism; D011817:Rabbits; D012711:Serum Albumin, Radio-Iodinated / Q000378:metabolism*
D011506:Proteins; D012711:Serum Albumin, Radio-Iodinated