title: DNA damage and repair in CHO cells following hematoporphyrin photoradiation.
abstract: The induction and repair of alkali labile lesions and single strand breaks in DNA of CHO cells following HpD photoradiation of X-irradiation has been examined. For treatments producing equal survival levels, the amount of DNA damage was less for HpD-photoradiated cells compared to X-irradiated cells. Both the time scale and the magnitude of repair of the DNA damage were the same for the 2 modalities, with the majority of repair occurring during the first 15 min of incubation and repair being essentially complete by 30 min.
mesh_terms: D000818:Animals; D002470:Cell Survival; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000528:radiation effects*; D004260:DNA Repair / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D006415:Hematoporphyrins / Q000494:pharmacology*; D008027:Light; D010053:Ovary / Q000378:metabolism*
chemical_list: D006415:Hematoporphyrins; D004247:DNA