The problem of nonresponding estrogen receptor-positive patients with advanced breast cancer.
Patients with advanced breast cancer and low or poor concentration of estrogen receptors in tumor biopsies have little chance of responding to endocrine therapy. This problem was seen in a group of nonresponding estrogen receptor-positive (ER+) patients. Some comments on possible explanations for this phenomenon are made and suggestions to overcome it are given.
D000970:Antineoplastic Agents / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy / Q000378:metabolism*; D004359:Drug Therapy, Combination; D005189:False Positive Reactions; D005260:Female; D006728:Hormones / Q000627:therapeutic use; D006801:Humans; D009362:Neoplasm Metastasis; D011960:Receptors, Estrogen / Q000378:metabolism*; D012075:Remission, Spontaneous
D000970:Antineoplastic Agents; D006728:Hormones; D011960:Receptors, Estrogen