Influence of dietary molybdenum on copper metabolism in ponies.
The effects of molybdenum ingestion on copper metabolism were investigated in bile duct-cannulated ponies fed diets containing 1.01, 27.4 and 107.3 ppm molybdenum. Copper metabolism was assessed by examination of 64Cu and stable copper excretion in feces, bile and urine. The addition of molybdenum to the diet decreased copper absorption and retention as a consequence of increased excretion of dietary copper in feces and increased excretion of absorbed copper in bile. Only 5% or less of the absorbed copper was excreted in urine regardless of dietary treatment. Biliary molybdenum excretion was only 0.86 mg per 100 kg of body weight per day even when ponies were fed the highest level of molybdenum. However, increased molybdenum ingestion produced elevations in protein bound copper in bile. Molybdenum was absorbed by ponies but urinary excretion was effective in eliminating most of the element from the body.
D000818:Animals; D001646:Bile / Q000378:metabolism*; D001652:Bile Ducts; D002404:Catheterization; D002570:Ceruloplasmin / Q000378:metabolism; D003300:Copper / Q000378:metabolism* / Q000652:urine; D004063:Digestion / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000032:analysis; D006736:Horses / Q000378:metabolism*; D008982:Molybdenum / Q000097:blood / Q000494:pharmacology*
D003300:Copper; D008982:Molybdenum; D002570:Ceruloplasmin