Exposure of newborn rats to pharmacologically active compounds may permanently alter carcinogen metabolism.
Administration of phenobarbital to mother rats during early lactation causes long-term, perhaps permanent, alteration of hepatic microsomal mixed-function oxidase activity and aflatoxin B1 adduct formation in the adult male offspring. These findings suggest that perinatal exposure to pharmacologically active compounds may be a determinant of cancer risk.
D000348:Aflatoxins / Q000378:metabolism; D000828:Animal Population Groups / Q000502:physiology*; D000818:Animals; D000833:Animals, Suckling / Q000502:physiology*; D002273:Carcinogens / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D005037:Ethylmorphine-N-Demethylase / Q000378:metabolism; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats
D000348:Aflatoxins; D002273:Carcinogens; D006899:Mixed Function Oxygenases; D010088:Oxidoreductases; D005037:Ethylmorphine-N-Demethylase; D010634:Phenobarbital