Effect of disulfiram on the alkylation of rat liver DNA by nitrosodiethylamine.
The extent of ethylation of guanine in 7 N and O 6 position in rat liver DNA was studied after chronic feeding with unlabelled nitrosodiethylamine followed by a single application of the 14C labelled drug. Disulfiram inhibits the alkylation of rat liver DNA. It was also shown that a discontinuous dosage of disulfiram protects against the alkylating effect of 14C nitrosodiethylamine only for a distinct period of time.
D000478:Alkylation; D000818:Animals; D004247:DNA / Q000378:metabolism*; D004052:Diethylnitrosamine / Q000037:antagonists & inhibitors*; D004221:Disulfiram / Q000494:pharmacology*; D008099:Liver / Q000378:metabolism; D008297:Male; D009602:Nitrosamines / Q000037:antagonists & inhibitors*; D051381:Rats
D009602:Nitrosamines; D004052:Diethylnitrosamine; D004247:DNA; D004221:Disulfiram