Type III hyperlipoproteinemia: defective metabolism of an abnormal apolipoprotein E.
The apolipoprotein E isolated from plasma of individuals with type III hyperlipoproteinemia (HLP) shows an abnormal pattern when it is examined by isoelectric focusing. Compared to apolipoprotein E from normal subjects, apolipoprotein E isolated from subjects with type III HLP had a decreased fractional catabolic rate in vivo in both type III HLP patients and normal individuals. The delayed catabolism of apolipoprotein E in type III HLP patients may be responsible for the lipid and lipoprotein abnormalities characteristic of these patients.
D001053:Apolipoproteins / Q000378:metabolism*; D006801:Humans; D006952:Hyperlipoproteinemia Type III / Q000097:blood*; D007526:Isoelectric Point; D008099:Liver / Q000378:metabolism; D008657:Metabolic Clearance Rate; D011955:Receptors, Drug / Q000378:metabolism
D001053:Apolipoproteins; D011955:Receptors, Drug