[Mechanism of silybin action, III. Resorption of the flavonolignane derivative silybin into rat liver cells (author's transl)].
After tritium labelling of silybin the time-dependent uptake of the flavonolignane derivative into rat liver was measured. Within the liver cells the distribution of silybin (and -metabolites) in cytosol, nuclear constituents and membrane material was determined and the accumulation of the flavonolignane derivative in cytosol and nuclear membranes confirmed by autoradiography. Within the nuclei a preferential binding on chromosomal proteins was found.
D000818:Animals; D001345:Autoradiography; D002467:Cell Nucleus / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D005419:Flavonoids / Q000378:metabolism*; D008099:Liver / Q000166:cytology / Q000378:metabolism*; D008297:Male; D008566:Membranes / Q000378:metabolism; D009698:Nucleoproteins / Q000378:metabolism; D011485:Protein Binding; D051381:Rats; D012838:Silymarin / Q000378:metabolism*
D005419:Flavonoids; D009698:Nucleoproteins; D012838:Silymarin
Untersuchungen zum Wirkungsmechanismus von Silybin, III. Aufnahme des Flavonolignans Silybin in Rattenleberzellen.