Reversal of prednisolone-induced inhibition of intestinal calcium-binding protein synthesis by 1 alpha-hydroxycholecalciferol in chicks.
Effects of prednisolone on the biochemical indices of blood serum, ash content in bones, calcium absorption and calcium-binding protein (CaBP) in the intestinal mucosa were studied. The oral administration of prednisolone (10 mg/kg) for 2 weeks reduced CaBP content and calcium absorption to the level typical for D-avitaminosis. The oral administration of 1 alpha-hydroxycholecalciferol (390 pmoles/day) in combination with prednisolone for a week returned calcium absorption and CaBP to the control value.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002135:Calcium-Binding Proteins / Q000096:biosynthesis*; D002645:Chickens; D006887:Hydroxycholecalciferols / Q000494:pharmacology*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism*; D011239:Prednisolone / Q000494:pharmacology*
D002135:Calcium-Binding Proteins; D006887:Hydroxycholecalciferols; D011239:Prednisolone; D002118:Calcium; C008088:alfacalcidol