Priming of the nasal mucosa by ragweed extract or by an irritant (ammonia).
Confirming previous work by Connell, it was shown that challenging nine subjects intranasally on successive days with short ragweed extract (SRW) resulted in a priming effect manifested by significantly augmented increases in nasal airways resistance as well as in increasing subjective symptoms. Priming was reproducible and transient. In contrast, significant priming to an irritant, ammonia gas (NH3), could not be unequivocally demonstrated over a similar period of time in these same subjects under the conditions employed. Also, priming these subjects with SRW extract failed to enhance responsiveness to NH3.
D000328:Adult; D000403:Airway Resistance; D000485:Allergens / Q000008:administration & dosage*; D000641:Ammonia / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D007509:Irritants; D008297:Male; D009297:Nasal Mucosa / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000175:diagnosis
D000485:Allergens; D007509:Irritants; D000641:Ammonia