[Animal experiments using adjuvant 5-FU and BCNU chemotherapy in stomach cancer].
Primary xenotransplantation of tissue from six human gastric cancers onto 'nude' mice was followed by a positive tumor take in all cases. One tumor showed aggressive growth and underwent a series of four passages on 'nude' mice. Characteristics of this tumor were an increasing speed of growth and pathohistological changes in the growth pattern. Chemotherapy with 5-FU and BCNU was followed by a decrease in volume compared with untreated controls. On the basis of our results a comparison between groups of patients and tumor-bearing 'nude' mice undergoing this chemotherapy is justified.
D000818:Animals; D002330:Carmustine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005472:Fluorouracil / Q000627:therapeutic use*; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000188:drug therapy; D013274:Stomach Neoplasms / Q000188:drug therapy*
D005472:Fluorouracil; D002330:Carmustine
Tierexperimentelle Untersuchungen zur Frage einer adjuvanten 5-FU-und BCNU-Chemotherapie beim Magencarcinom.