Flow microfluorometric analysis of the cell cycle phase cytotoxicity of ARA-C.
Mouse L1210 leukemia cells killed by ara-C, an anti-tumor agent widely used against leukemia, were demonstrated to be in the S phase of the cell cycle by flow microfluorometry. The point in S phase at which the L1210 cells died was shown to be dose dependent. At higher concentrations of ara-C cells died earlier in the S phase.
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects*; D002470:Cell Survival / Q000187:drug effects; D003561:Cytarabine / Q000494:pharmacology*; D004273:DNA, Neoplasm / Q000378:metabolism; D005470:Fluorometry / Q000379:methods; D007939:Leukemia L1210 / Q000378:metabolism; D051379:Mice
D004273:DNA, Neoplasm; D003561:Cytarabine