Evidence that acetaminophen and N-hydroxyacetaminophen form a common arylating intermediate, N-acetyl-p-benzoquinoneimine.
D000082:Acetaminophen / Q000031:analogs & derivatives* / Q000378:metabolism*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D016227:Benzoquinones; D003545:Cysteine / Q000494:pharmacology; D007097:Imines / Q000378:metabolism*; D066298:In Vitro Techniques; D008862:Microsomes, Liver / Q000378:metabolism; D006899:Mixed Function Oxygenases / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010084:Oxidation-Reduction; D051381:Rats
D016227:Benzoquinones; D007097:Imines; D000082:Acetaminophen; D009249:NADP; C017372:N-hydroxyacetaminophen; D006899:Mixed Function Oxygenases; C028473:N-acetyl-4-benzoquinoneimine; D003545:Cysteine; D001205:Ascorbic Acid