[Influence of propyl-gallate and 2-mercaptopropionylglycine on the development of acute inflammatory reactions and on biosynthesis of PGE2].
Anti-inflammatory activity of Propyl Gallate and 2.mercaptopropionylglycine, administered intraperitoneally to the rat, was evaluated against paw edema induced by Carrageenan, Bradykinin, Serotonin and Dextran. In addition, the influence of these chemicals on PGE2 formation from added arachidonic acid to spleen microsomal fraction incubated "in vitro" was assayed. Our results indicate Propyl Gallate and 2.mercaptopropionylglycine depress significantly the development of acute inflammatory reactions provoked by the above mentioned phlogogens and are able to limit the biosynthesis of PGE2. The last inhibitory activity appears to be less potent than that exerted by some non-steroidal anti-inflammatory agents, namely Indomethacin and Oxametacine, which act primarily by interfering with cyclo-oxigenase activity. In our opinion, the anti-inflammatory effect of Propyl Gallate and 2.mercaptopropionylglycine might be dependent on both the scavenger properties of the two compounds against some final products of lipid peroxides (aldehydes) originated at the inflammation site and the partial inhibition of the formation of PGE2 by acting on the cyclo-oxigenase system.
D000603:Amino Acids, Sulfur / Q000494:pharmacology*; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001095:Arachidonic Acids / Q000378:metabolism; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D005707:Gallic Acid / Q000031:analogs & derivatives*; D008297:Male; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D011435:Propyl Gallate / Q000494:pharmacology*; D011458:Prostaglandins E / Q000096:biosynthesis*; D051381:Rats; D013154:Spleen / Q000187:drug effects / Q000378:metabolism; D008625:Tiopronin / Q000494:pharmacology*
D000603:Amino Acids, Sulfur; D000893:Anti-Inflammatory Agents; D001095:Arachidonic Acids; D011458:Prostaglandins E; D005707:Gallic Acid; D011435:Propyl Gallate; D008625:Tiopronin
Influenze del propil gallato e della 2-mercaptopropionilglicina sullo sviluppo di reazioni infiammatorie acute e sulla biosinte si di PGE2.