title: Experimental induction of ovine polioencephalomalacia.
abstract: Polioencephalomalacia (PEM) was induced in sheep, with an overall incidence of 63 per cent, using local bracken fern (Pteridium esculentum) rhizomes as a source of thiaminase type 1 and pyridine as a basic cosubstrate. The condition was thiamin responsive and PEM was confirmed by histopathological examination. In a separate experiment to examine the effect of pyridine, it was shown that, for the duration of the experiment, pyridine had no toxic effect and caused no histologically detectable brain lesions.
mesh_terms: D019883:Alkyl and Aryl Transferases; D000818:Animals; D001927:Brain Diseases / Q000139:chemically induced / Q000662:veterinary*; D008297:Male; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced*; D014166:Transferases / Q000494:pharmacology*
chemical_list: D014166:Transferases; D019883:Alkyl and Aryl Transferases; C022737:thiamin pyridinylase