Phenytoin elimination kinetics in two children with drug intoxication.
Two girls aged 6 and 10 years treated with anticonvulsants developed nystagmus and ataxia. The peak plasma concentrations of phenytoin were 42.6 and 46.6 microgram/ml, respectively, compatible with phenytoin toxicity. The decline in plasma phenytoin levels did not fit first order kinetics, but followed Michaelis-Menten kinetics.
D001259:Ataxia / Q000139:chemically induced; D002648:Child; D005260:Female; D006801:Humans; D007700:Kinetics; D009759:Nystagmus, Pathologic / Q000139:chemically induced; D010672:Phenytoin / Q000097:blood / Q000506:poisoning* / Q000652:urine
D010672:Phenytoin