[Ultrastructural morphology of mitochondria of malignant keratinocytes in laryngeal carcinoma (author's transl)].
The ultrastructural morphology of mitochondria in malignant keratinocytes in invasive squamous cell carcinoma of the larynx was studied electron microscopically. Structural alterations in the mitochondrial membranes, the matrix, and the cristae mitochondrales were observed. Mitochondria with multiple membrane complexes forming myelin-like figures were also found. Some malignant keratinocytes exhibited intramitochondrial osmiophilic inclusion bodies which were excluded from the mitochondrial matrix by a limiting membranous structure. Other structural changes were the occurrence of tube-like crystalloid structures in the mitochondria of certain carcinoma cells. The observations are compared to similar structures described in other cell systems. The mitochondrial alterations are discussed in terms as to their possible functional significance in carcinoma cells.
D002294:Carcinoma, Squamous Cell / Q000648:ultrastructure*; D006801:Humans; D007425:Intracellular Membranes / Q000648:ultrastructure; D007822:Laryngeal Neoplasms / Q000648:ultrastructure*; D008854:Microscopy, Electron; D008928:Mitochondria / Q000648:ultrastructure*
Die ultrastrukturelle Morphologie der Mitochondrien in malignen Keratinozyten des Kehlkopfkarzinoms.