title: Monitoring of blood coagulation in open heart surgery. I. Effects of conventional dosages of heparin and protamine.
abstract: In twenty unselected patients coming for surgery with cardio-pulmonary by-pass coagulation studies were performed. Laboratory results before and after by-pass were compared with serial measurements of ACtivated Clotting Times (ACT) during and after operation using conventional dosages of heparin and protamine. Values of ACT's are presented and compared with a previously published protocol according to Bull (1). Monitoring of ACT during operation was found to be easily applicable and highly desirable. Overdosage of both heparin and protamine was suggested as a correctable cause of proven abnormal coagulation after cardio-pulmonary by-pass.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001777:Blood Coagulation / Q000187:drug effects*; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002648:Child; D002675:Child, Preschool; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007430:Intraoperative Care; D008875:Middle Aged; D008991:Monitoring, Physiologic; D011479:Protamines / Q000008:administration & dosage*; D014914:Whole Blood Coagulation Time
chemical_list: D011479:Protamines; D006493:Heparin