Cytogenetic and cytokinetic investigations on lymphocytes from workers occupationally exposed to tetrachloroethylene.
Lymphocytes from 10 factory workers, who had been exposed to tetrachloroethylene for 3 months to 18 years, were examined for possible chromosome aberration, increased sister chromatid exchanges, and modified cell-cycle kinetics. The exposure intensity was such that the workroom air analyses disclosed 92 ppm as a geometric mean in the workshops for Group 1 (6 workers from decreasing workshops), but was in the range of 10 to 40 ppm for Group 2 (4 workers from a support department). Urinalyses for total trichloro-compounds showed 50.7 and 19.0 mg (as trichloroacetic acid)/l as a geometric mean in Group 1 and 2, respectively. cytogenetic and cytokinetic studies did not reveal any significant dose-related changes in chromosome aberrations (either numerical or structural), SCEs rate, the proportion of M2 + M3 metaphases or mitotic index, compared with concurrent controls. Mitomycin C treatment also failed to induce any difference between exposed workers and controls.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000388:Air / Q000032:analysis; D000395:Air Pollutants, Occupational / Q000009:adverse effects; D002869:Chromosome Aberrations / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D008937:Mitomycins / Q000009:adverse effects; D013750:Tetrachloroethylene / Q000009:adverse effects* / Q000032:analysis; D014556:Urine / Q000032:analysis
D000395:Air Pollutants, Occupational; D008937:Mitomycins; D013750:Tetrachloroethylene