[Selective activation of DNA biosynthesis in rat kidneys following ethyleneimine administration].
Selective activation of RNA and DNA synthesis in response to ethylene imine accompanied by subsequent corresponding increase in amount of the nucleic acids, was found in rat kidney. Maximal efficiency of ethylene imine was manifested after administration of non-lethal doses 2.4 mg/kg; lethal doses of the poison were not effective. The alterations were characteristic for both young and adult animals. Similar phenomenon was not detected either in tissues with rapid renewal of cells (thymus, spleen) or in other tissues (liver, lungs).
D000818:Animals; D001388:Aziridines / Q000494:pharmacology* / Q000506:poisoning; D001389:Azirines / Q000494:pharmacology*; D004247:DNA / Q000096:biosynthesis*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D008297:Male; D009928:Organ Specificity; D051381:Rats; D013154:Spleen / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism
D001388:Aziridines; D001389:Azirines; D004247:DNA
Izbiratel'naia aktivatsiia biosinteza DNK v pochkakh krys pod vliianiem étilenimina.