[Effect of a number of enzyme preparations on the course of experimental parotitis].
Increase in the weight of rat parotid glands, decrease in the protein concentration and the activity of alpha-amylase with simultaneous activation of the proteolytic enzymes (caseinolytic activity at pH 7.6, activity of cathepsins at pH 5.5) were observed in pyo-traumatic parotiditis. Local administration of the protease inhibitor (contrical) or intramuscular treatment with trypsin showed the positive medical effect--decrease of the gland weight, increase in the protein concentration and in the alpha-amylase activity together with lowering in the activity of proteinases. Intramuscular administration of antimicrobic enzymes (lysozyme, RNase, DNAase) did not affect the pyo-traumatic parotiditis. Application of proteolytic enzymes or their inhibitors is recommended for clinical treatment of parotidites.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D003851:Deoxyribonucleases / Q000627:therapeutic use; D004338:Drug Combinations; D009113:Muramidase / Q000627:therapeutic use; D010309:Parotitis / Q000188:drug therapy*; D011480:Protease Inhibitors / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D012260:Ribonucleases / Q000627:therapeutic use; D013492:Suppuration; D014357:Trypsin / Q000627:therapeutic use; D014361:Trypsin Inhibitors / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; D003851:Deoxyribonucleases; D012260:Ribonucleases; D009113:Muramidase; D014357:Trypsin
Vliianie riada fermentnykh preparatov na techenie éksperimental'nogo parotita.