Prolactin levels in cerebrospinal fluid of patients with chronic schizophrenia.
Baseline concentrations of prolactin (PRL) was determined in the CSF of 28 lobotomized and 28 non-lobotomized patients with chronic schizophrenia. The mean PRL level of the female patients was significantly higher than that of the male patients (p < 0.001). In addition, non-lobotomized patients had significantly higher concentrations of CSF PRL than patients of the lobotomized group (p < 0.05). On the other hand, patients belonging to the latter group exhibited significantly more central as well as cortical brain atrophy than the patients on whom no psychosurgery had been performed (0.05 > p < 0.001). The significance of cerebrospinal PRL as an index of central dopamine metabolism is discussed.
D000328:Adult; D001284:Atrophy; D001921:Brain / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011388:Prolactin / Q000134:cerebrospinal fluid*; D011612:Psychosurgery / Q000009:adverse effects; D012559:Schizophrenia / Q000134:cerebrospinal fluid*; D012737:Sex Factors
D011388:Prolactin