[9-Nitro- and 9-amino-ellipticines and derivatives: synthesis and pharmacologic properties].
Preparation of 9-nitroellipticine starting from 1,4-dimethyl-6-nitrocarbazole and its reduction according to the Béchamp method followed by acetylation. The salts of 9-nitro-2-methyl- and 9-amino-2-methyl ellipticinium were tested for cytotoxic activity on different tumor strains for mutagenicity, for affinity for DNA and cytochrome P450 and for toxicity in the mouse. The results obtained were compared with those found under the same conditions with 9-hydroxyellipticine and its corresponding ellipticinium salt.
D000470:Alkaloids / Q000138:chemical synthesis*; D000818:Animals; D002279:Carcinoma 256, Walker / Q000188:drug therapy; D002478:Cells, Cultured; D006224:Cricetinae; D003412:Cricetulus; D004611:Ellipticines / Q000138:chemical synthesis* / Q000494:pharmacology; D007939:Leukemia L1210 / Q000188:drug therapy; D008175:Lung Neoplasms / Q000188:drug therapy; D051379:Mice; D009152:Mutagenicity Tests; D009374:Neoplasms, Experimental / Q000188:drug therapy; D051381:Rats
D000470:Alkaloids; D004611:Ellipticines
Nitro-9 et amino-9 ellipticines et dérivés: synthèse et propriétés pharmacologiques.