Plasma imipramine levels and demethylase activity in the liver of stressed animals.
The steady-state values in rats after a second 14-day period of daily subcutaneous administration of imipramine were the same as during the first period; liver demethylation activity rose for up to 3 days and then returned to normal. The imipramine-binding capacity of the serum, brain myelin, synaptosomes and mitochondria did not alter after repeated administration, but a decrease was found in the red blood cells. Stress (an electric current or immobilization) led to marked reduction of the plasma imipramine level, with a simultaneous increase in liver demethylase activity. Adrenalectomy caused a drop in demethylase activity; stress had no effect either on these values or on imipramine levels.
D000315:Adrenalectomy; D000818:Animals; D001921:Brain / Q000378:metabolism; D007099:Imipramine / Q000097:blood* / Q000378:metabolism; D008099:Liver / Q000201:enzymology*; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D009186:Myelin Sheath / Q000378:metabolism; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D051381:Rats; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*; D013574:Synaptosomes / Q000378:metabolism
D010089:Oxidoreductases, N-Demethylating; D007099:Imipramine