[Compounds with potential antitumor activity. VI. Esters of 6-substituted 5-hydroxymethylimidazo(2,1-b)thiazoles].
6-Substituted 5-hydroxymethylimidazo[2.1-b]thiazoles and 2,3-dihydro-5-hydroxymethylimidazo[2,1-b]thiazoles (VII - XII) were prepared by reducing the corresponding aldehydes (I - VI) with NaBH4. Among the acetic (VII a - XII a), methylcarbamic (VII b - XII b) and ethylcarbamic esters (VII c - XII c), compound (VII a) was active in a preliminary P388 leukemia test.
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis*; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D013844:Thiazoles
Composti a presunta attività antitumorale. Nota VI - Esteri di 5-idrossimetilimidazo [2,1-b]tiazoli 6-sostituiti.