Cyclophosphamide-induced spermatogenic effects detected in the F1 generation by behavioral testing.
Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F1 progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.
D000818:Animals; D001362:Avoidance Learning; D001522:Behavior, Animal / Q000502:physiology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D005260:Female; D008124:Locomotion; D008297:Male; D009043:Motor Activity; D009154:Mutation; D051381:Rats; D013091:Spermatogenesis / Q000187:drug effects*
D003520:Cyclophosphamide