[Effect of circulating insulin on liver damage by CCl4 in the rat. I. Biochemical studies].
The authors have studied the damaging effects of CCl4 (0.05ml/Kg) in healthy rats, in alloxan-diabetic rats, and in rats treated with tolbutamide per os (100mg/Kg) for twenty days. Biochemical studies in these animals demonstrated that actually hyperinsulinemia has a preventive effect in relation to the damage produced by CCl4 as demonstrated by a decrease in bilirubinemia and transaminasemia.
D000818:Animals; D001663:Bilirubin / Q000097:blood; D002252:Carbon Tetrachloride Poisoning / Q000503:physiopathology*; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D006946:Hyperinsulinism / Q000503:physiopathology*; D008099:Liver / Q000187:drug effects*; D051381:Rats; D000637:Transaminases / Q000097:blood
D000637:Transaminases; D001663:Bilirubin
Effetti dell'insulina circolante sull'azione epatolesiva da CCl4 nel ratto. I. Aspetti bioumorali.