High-performance liquid chromatographic determination of metaraminol bitartrate in the presence of parabens.
A high-performance liquid chromatographic (HPLC) procedure was developed for the determination of metaraminol bitartrate in the presence of methylparaben and propylparaben. Reversed-phase ion-pair chromatography was employed using dioctyl sodium sulfosuccinate as the counterion. The current official USP procedure for the determination of metaraminol requires dilution, extraction, and measurement of UV absorption. The HPLC procedure is rapid and precise and correlates well with the USP XX procedure. It can be used for metaraminol injectables as well as the raw material.
D002851:Chromatography, High Pressure Liquid / Q000379:methods; D008680:Metaraminol / Q000032:analysis*; D010226:Parabens
D010226:Parabens; D008680:Metaraminol