Polysaccharide accumulation in the central nervous system of D-penicillamine-treated rats.
A complex polysaccharide accumulation was observed in the central nervous system (CNS) of rats treated with D-penicillamine similar to Lafora-like bodies. They have histochemical similarities comparable to bodies described in previous studies of Lafora disease. The clinical usefulness of D-penicillamine has been limited by many side effects including renal damage. It is suggested that, in addition to D-penicillamine nephropathy, there are toxic effects of this drug on the CNS.
D000818:Animals; D002490:Central Nervous System / Q000032:analysis / Q000187:drug effects*; D008297:Male; D010396:Penicillamine / Q000009:adverse effects / Q000494:pharmacology*; D011134:Polysaccharides / Q000032:analysis*; D051381:Rats
D011134:Polysaccharides; D010396:Penicillamine