Influence off haemodilution on the potency of neuromuscular blocking drugs.
The potencies of suxamethonium, pancuronium, and tubocurarine were increased, as shown by a parallel shift to the left of cumulative dose-response curves, following normovolaemic haemodilution before operation. This is attributed to an increase in cardiac output, to a decrease in protein binding and, in the case of suxamethonium, to a decrease in cholinesterase activity.
D000328:Adult; D000368:Aged; D001798:Blood Proteins / Q000032:analysis; D002802:Cholinesterases / Q000097:blood; D004305:Dose-Response Relationship, Drug; D005260:Female; D006400:Hematocrit; D006438:Hemodilution; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D008297:Male; D008875:Middle Aged; D009469:Neuromuscular Junction / Q000187:drug effects; D010197:Pancuronium / Q000494:pharmacology*; D013390:Succinylcholine / Q000494:pharmacology*; D014403:Tubocurarine / Q000494:pharmacology*
D001798:Blood Proteins; D006454:Hemoglobins; D002802:Cholinesterases; D013390:Succinylcholine; D010197:Pancuronium; D014403:Tubocurarine