[Increase in DNA repair after treatment of mice with N-methyl-N-nitrosourea].
Inbred Balb/C mice were treated in vivo for three days with ip injections of the carcinogen N-Methyl-N-nitrosourea (25 mg/kg body weight). Reported data show that the spleens from treated animals are strongly reduced, functionally impaired and that they present a higher capacity of repairing their DNA after damage exerted in vitro by the same carcinogen or by ultraviolet rays (900 ergs/mm2).
D000818:Animals; D004260:DNA Repair / Q000187:drug effects*; D008297:Male; D008770:Methylnitrosourea / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009607:Nitrosourea Compounds / Q000494:pharmacology*; D014466:Ultraviolet Rays
D009607:Nitrosourea Compounds; D008770:Methylnitrosourea
Aumento della riparazione del DNA dopo trattamento di topi con N-metil-N-nitrosourea.