[Antimutagenic effectiveness of pyrimidine derivatives in lesions of the bone marrow cell chromosome apparatus in mice infected with measles or poliomyelitis viruses].
It is determined that the number of marrow cells with cytogenetic disturbances grows in mice infected with measles or polymyelitis viruses. The level of marrow cells with disturbances is much lower in the mice fed with methyluracilum or pentoxylum before infection. The level of deteriorated cells also decreases when the mice were fed with the mentioned drug after infection. In an analogous experiment with polymyelitis viruses the antimutagenic effect was not determined.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000648:ultrastructure; D001855:Bone Marrow Diseases / Q000188:drug therapy*; D002869:Chromosome Aberrations / Q000188:drug therapy*; D025063:Chromosome Disorders; D004353:Drug Evaluation, Preclinical; D008457:Measles / Q000188:drug therapy*; D051379:Mice; D009154:Mutation; D010432:Pentoxyl / Q000627:therapeutic use; D011051:Poliomyelitis / Q000188:drug therapy*; D011743:Pyrimidines / Q000627:therapeutic use*; D013997:Time Factors; D014498:Uracil / Q000031:analogs & derivatives / Q000627:therapeutic use
D011743:Pyrimidines; D014498:Uracil; C008378:6-methyluracil; D010432:Pentoxyl
Amtimutagennaia éffektivnost' pirimidinovykh proizvodnykh pri porazheniiakh khromosomnogo apparata kletok kostnogo mozga mysheĭ, zarazhennykh virusami kori i poliomielita.