Azathioprine-induced pancytopenia. Occurrence in two patients with connective-tissue diseases.
Two patients became severely pancytopenic while receiving azathioprine in low dosages for treatment of connective-tissue diseases. While mild hematologic complications are common with this drug, we believe that the degree of bone marrow suppression exhibited in these two patients is unusual, especially at the dosages (0.75 and 1.25 mg/kg/day) of azathioprine being used.
D000328:Adult; D001171:Arthritis, Juvenile / Q000188:drug therapy; D001379:Azathioprine / Q000009:adverse effects* / Q000627:therapeutic use; D001772:Blood Cell Count; D001853:Bone Marrow / Q000000981:diagnostic imaging; D003240:Connective Tissue Diseases / Q000188:drug therapy*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy; D008875:Middle Aged; D010198:Pancytopenia / Q000139:chemically induced* / Q000473:pathology; D011241:Prednisone / Q000627:therapeutic use; D011859:Radiography
D001379:Azathioprine; D011241:Prednisone