Latent period and yield of chemically-induced skin tumors in chimeric mice.
The induction of skin tumors in chimeras produced by 2 methods and between 2 different parental sets was investigated. The yield and latent period of the tumors were compared in the several types of chimeras. In chimeras between strains of mice with long and short latent periods, a short latent period was obtained. Some of the tumors in these animals were derived from the late-responding cell type. The presence of cells from 2 strains in a single animal may modify the latent period of the late responding strain-derived cells in the chimeras.
D000287:Administration, Topical; D000818:Animals; D002273:Carcinogens / Q000008:administration & dosage* / Q000633:toxicity; D002678:Chimera / Q000187:drug effects*; D005260:Female; D051379:Mice; D009374:Neoplasms, Experimental / Q000139:chemically induced; D011930:Reaction Time / Q000187:drug effects*; D012878:Skin Neoplasms / Q000139:chemically induced*
D002273:Carcinogens