[Experimental effect of a lupinine-based homopolymer on blood coagulation in animals].
Effect of an active heparin antagonist, artificial polymer manufactured on the basis of alkaloid lupinin (poly-MAKL-C2H5J with a molecular weight of 20.000), on blood coagulation was studied to show that excessive doses of the compound exert an anticoagulant effect on the blood. Prolongation of blood coagulation is the result of the decreased activity of factor Y, contained by the prothrombin complex, as well as the decreased activity of factor VIII and transitional thrombocytopenia.
D000470:Alkaloids / Q000494:pharmacology*; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects*; D005260:Female; D006494:Heparin Antagonists; D008297:Male; D008970:Molecular Weight; D011108:Polymers / Q000494:pharmacology*; D011807:Quinolizines / Q000494:pharmacology*; D011817:Rabbits; D013034:Sparteine / Q000031:analogs & derivatives; D013921:Thrombocytopenia / Q000139:chemically induced; D013997:Time Factors; D000093843:Quinolizidine Alkaloids
D000470:Alkaloids; D006494:Heparin Antagonists; D011108:Polymers; D011807:Quinolizines; D013034:Sparteine; C015971:lupinine; D000093843:Quinolizidine Alkaloids
Vliianie gomopolimera na osnove lupinina na svertyvaemost' krovi zhivotnykh v éksperimente.