title: Health hazard alert--2-Nitropropane.
abstract: OSHA and NIOSH conclude that 2-nitropropane (2-NP) is a confirmed carcinogen in laboratory rats. in 1977, NIOSH summarized the carcinogenic potential of 2-NP in Current Intelligence Bulletin no. 17. Since then data have been developed which reinforce and expand the original findings. As a confirmed animal carcinogen, 2-NP has the potential to cause cancer in humans. This document summarizes the cancer studies of 2-NP in laboratory animals and its toxic effects in humans. It recommends that worker exposure to 2-NP be reduced to the lowest feasible levels. The document recommends actions, procedures, and medical programs that should be used to protect workers from exposure to 2-NP.
mesh_terms: D000473:Alkanes / Q000633:toxicity*; D000818:Animals; D002274:Carcinogens, Environmental; D005260:Female; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced; D008297:Male; D008452:Maximum Allowable Concentration; D009595:Nitroparaffins / Q000633:toxicity*; D009784:Occupational Diseases / Q000139:chemically induced*; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity; D011482:Protective Devices / Q000592:standards; D051381:Rats; D012449:Safety; D012997:Solvents / Q000633:toxicity*; D014481:United States; D014483:United States Dept. of Health and Human Services
chemical_list: D000473:Alkanes; D002274:Carcinogens, Environmental; D009595:Nitroparaffins; D012997:Solvents; C016617:2-nitropropane; D011407:Propane