title: Endoscopic manometry of pancreatic and biliary sphincter zones in man. Basal results in healthy volunteers.
abstract: An endoscopic manometric technique was applied to the study of intraductal biliary and pancreatic pressures and sphincter activity in normal subjects. A perfused system using a modified endoscopic retrograde cholangiopancreatography catheter was tested and found to provide reliable ductal and phasic recordings. Twenty-five healthy volunteers, aged 19-37, underwent endoscopic manometry under diazepam sedation. Distinct zones of high-pressure phasic activity were identified on pull-through from the pancreatic duct and common bile duct at mean distances of 4.5 and 5.0 mm, respectively, from the papillary orifice with frequencies of 7.0 +/- 1.8 (mean +/- SD) and 5.6 +/- 2.4 waves/min, respectively. These were considered to represent separate pancreatic duct and bile duct sphincters. Peak pancreatic duct sphincter pressure (47.6 +/- 8.2 mm Hg) and bile duct sphincter pressure (57.2 +/- 10.7 mm Hg) were similar. Pancreatic duct pressure was 11.4 +/- 3.0 mm Hg and common bile duct pressure was 3.0 +/- 2.5 mm Hg. Values were adjusted to duodenal pressure as zero reference. The ductal and sphincteric pressures reported in this study provide a basis for the assessment of physiological, pharmacological, pathophysiological, and surgical effects on this area.
mesh_terms: D000328:Adult; D002404:Catheterization / Q000379:methods; D003287:Contrast Media / Q000494:pharmacology; D003975:Diazepam / Q000494:pharmacology; D004386:Duodenum / Q000502:physiology*; D004724:Endoscopy / Q000379:methods; D005260:Female; D005769:Gastrointestinal Motility; D006801:Humans; D008297:Male; D008365:Manometry / Q000379:methods*; D010183:Pancreatic Ducts / Q000502:physiology*; D011312:Pressure; D009803:Sphincter of Oddi / Q000502:physiology
chemical_list: D003287:Contrast Media; D003975:Diazepam