[Changes in the functional activity of cells of the mononuclear phagocytizing system in mice of different ages].
The capacity to phagocytize and the lysosomal cathepsin activity of mononuclear phagocytic system (MPS) cells in mice of different age was studied beginning from the first day of life. The lowest cathepsin activity in peritoneal macrophage cells was revealed in one day-old mice. The activity rose by the third day, approaching the level of adult mice on day 21. The SRBC uptake by macrophages of different origin was not identical in different age groups. The highest uptake was demonstrated by peritoneal macrophages of one-day-old mice. The level of phagocytizing activity in 4-5-day-old mouse macrophages was still high, decreased in 14-day-old mice and reached the control (adult) level in 28-day-old mice. Conversely, spleen macrophages of 1-4-day-old mice had little phagocytizing activity. This activity rose in 2-week-old mice and reached 100% in 2-month old mice. The experiments have shown that lysosomal function and phagocytizing capacity of macrophages obtained from different mouse organs are age-associated. It is suggested that one of the mechanisms of immunologic incompetence lies in the immaturity of MPS cell lysosomes.
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn / Q000276:immunology*; D001202:Ascitic Fluid / Q000166:cytology; D002403:Cathepsins / Q000378:metabolism*; D008247:Lysosomes / Q000201:enzymology; D008264:Macrophages / Q000201:enzymology / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D010587:Phagocytosis; D013154:Spleen / Q000166:cytology
D002403:Cathepsins
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