[Veterinary anesthesiology, a pharmacological model (author's transl)].
Different mechanisms are involved in drug interactions, especially between anesthetics and drug administrated before and during anesthesia: liver disease, bioavailability related to the route of administration, displacement of the protein-bound of the part, etc. Two peculiarities of veterinary anesthesiology were found useful to evaluate such drug interactions: changes in the frequency of the cyclic contraction of the reticulum (sheep) and decrease in the central body temperature (cat). These criteria were used in addition to electroencephalographic recordings to appreciate the inhibition of microsomal penthiobarbital metabolism by chloramphenicol, the effect of phenylbutazone on plasma-protein displacement and the non-bioavailability of chloramphenicol by the subcutaneous route.
D000758:Anesthesia / Q000662:veterinary*; D000818:Animals; D001682:Biological Availability; D001798:Blood Proteins / Q000378:metabolism; D001831:Body Temperature / Q000187:drug effects; D002415:Cats; D002701:Chloramphenicol / Q000008:administration & dosage / Q000494:pharmacology; D009119:Muscle Contraction / Q000187:drug effects; D010653:Phenylbutazone / Q000494:pharmacology; D011485:Protein Binding; D012159:Reticulum / Q000187:drug effects; D012756:Sheep; D013874:Thiopental / Q000097:blood / Q000494:pharmacology*
D001798:Blood Proteins; D002701:Chloramphenicol; D010653:Phenylbutazone; D013874:Thiopental
L'anesthésiologie vétérinaire. Modèle pharmacologique.