Inner ear disease characterized by rolling in C3H mice.
A neurologic disease characterized by rolling developed in C3H mice. Pseudomonas aeruginosa was isolated from the middle and internal ears or meninges of affected mice. The principal pathologic finding was aggressive, primary, purulent otitis media, with extension to the inner ear, acoustic nerve, and meninges. Stresses that may have contributed to induction of the disease were not delineated; however, acidification of the drinking water resulted in near elimination of the disease.
D000818:Animals; D001522:Behavior, Animal; D007758:Ear, Inner / Q000473:pathology; D007759:Labyrinth Diseases / Q000662:veterinary*; D007762:Labyrinthitis / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D051379:Mice; D008809:Mice, Inbred C3H; D011552:Pseudomonas Infections / Q000175:diagnosis / Q000473:pathology / Q000662:veterinary*; D012376:Rodent Diseases / Q000175:diagnosis* / Q000473:pathology