Distribution and antitumoral activity of adriamycin combined with warfarin in mice.
The distribution of adriamycin (AM) in C57Bl/6 mice bearing intramuscular Lewis lung carcinoma under the influence of combined treatment with warfarin (W) was investigated by a fluorimetric procedure. AM was injected IV at the dose of 7.5 mg/kg 14 days after tumor transplantation and W was given in the drinking water for 96 h, starting 24 h before AM.. No substantial modifications in the serum and tissue distribution of AM fluorescence were observed under combined short-term treatment with W.
D000818:Animals; D002277:Carcinoma / Q000188:drug therapy* / Q000378:metabolism; D004317:Doxorubicin / Q000008:administration & dosage* / Q000378:metabolism; D004359:Drug Therapy, Combination; D007700:Kinetics; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009206:Myocardium / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D014859:Warfarin / Q000008:administration & dosage* / Q000378:metabolism
D014859:Warfarin; D004317:Doxorubicin