[Redox and phosphorylation equilibrium of the central metabolic pathway: rat liver profile in controls and after treatment with dichloroacetate and phenformin following dichloroacetate].
Glycolytic-, oxidative shunt, and mitochondrial metabolites, UDPG and high-energy-phosphates were measured in the liver of rats treated with Phenformin and/or Sodium Dichloroacetate. The substrate level profiles of the acute (90-60 min before sacrifice) treated groups were studied, and the interrelationships among substrate-coupled pyridine dependent dehydrogenase-redox potentials, the high energy-potentials of cytosolic and mitochondrial spaces, in the above-mentioned conditions, are discussed.
D000085:Acetates / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D003600:Cytosol / Q000378:metabolism; D003999:Dichloroacetic Acid / Q000494:pharmacology*; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008930:Mitochondria, Liver / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009249:NADP / Q000378:metabolism; D010629:Phenformin / Q000494:pharmacology*; D010710:Phosphates / Q000378:metabolism; D051381:Rats
D000085:Acetates; D010710:Phosphates; D009243:NAD; D009249:NADP; D000244:Adenosine Diphosphate; D000255:Adenosine Triphosphate; D003999:Dichloroacetic Acid; D010629:Phenformin
Equilibrii redox e fosforilativi delle vie centrali metaboliche: profilo epatico in condizioni di controllo, di trattamento con dicloroacetato e con fenformina seguita da dicloroacetato nel ratto.