title: Thyroid hormone modulation of X ray-induced in vitro neoplastic transformation.
abstract: The direct oncogenic potential of X rays has been demonstrated by the in vitro neoplastic transformation of mammalian cells in culture, a technique which permits the study of oncogenesis in the absence of host-specific effects. Although several agents are known to modulate in vitro neoplastic transformation by X rays, little is known of the effects of hormones. We now describe experiments which show that the presence of thyroid hormone is necessary for in vitro neoplastic transformation by X rays in cells of an established mouse fibroblast culture (C3H/10T1/2) and in early-passage diploid hamster embryo cells.
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000528:radiation effects; D002478:Cells, Cultured / Q000528:radiation effects; D003043:Cocarcinogenesis; D006224:Cricetinae; D003470:Culture Media; D004307:Dose-Response Relationship, Radiation; D051379:Mice; D013963:Thyroid Hormones / Q000494:pharmacology*; D013997:Time Factors; D014965:X-Rays
chemical_list: D003470:Culture Media; D013963:Thyroid Hormones