title: Extensive tissue necrosis associated with warfarin sodium therapy.
abstract: Skin and soft tissue necrosis is an uncommon but increasingly recognized complication of coumarin anticoagulant therapy. A patient is described with extensive involvement of all four extremities and the nose, requiring amputation of three extremities. The characteristic clinical features of the disorder are reviewed, with a discussion of the pathology, pathogenesis, and possible treatment modalities.
mesh_terms: D000368:Aged; D003238:Connective Tissue / Q000473:pathology; D005121:Extremities / Q000473:pathology; D005260:Female; D005734:Gangrene / Q000139:chemically induced* / Q000628:therapy; D006801:Humans; D009336:Necrosis / Q000139:chemically induced* / Q000628:therapy; D009666:Nose / Q000473:pathology; D012867:Skin / Q000473:pathology; D014859:Warfarin / Q000009:adverse effects*
chemical_list: D014859:Warfarin