[Changes in oxidative phosphorylation following exposure to sodium caffeine benzoate].
Sodium caffeine-benzoate at concentrations 6 x 10(-6) M and 6 x 10(-5) M increased the rate of free oxidation of succinic acid in myocardial mitochondria suggesting possibility of uncoupling of respiration and oxidative phosphorylation. The drug stimulates the free flow of electrons in respiratory chain. These phenomena might be responsible for an increase in metabolism and body temperature in patients after the treatment with this drug.
D000818:Animals; D001565:Benzoates / Q000494:pharmacology*; D002110:Caffeine / Q000494:pharmacology*; D004285:Dogs; D004338:Drug Combinations / Q000494:pharmacology; D005260:Female; D005971:Glutamates / Q000378:metabolism; D008297:Male; D008314:Malonates / Q000378:metabolism; D008929:Mitochondria, Heart / Q000187:drug effects* / Q000378:metabolism; D010085:Oxidative Phosphorylation / Q000187:drug effects*; D010101:Oxygen Consumption / Q000187:drug effects; D013386:Succinates / Q000378:metabolism; D014475:Uncoupling Agents
D001565:Benzoates; D004338:Drug Combinations; D005971:Glutamates; D008314:Malonates; D013386:Succinates; D014475:Uncoupling Agents; D002110:Caffeine; C025741:caffeine, sodium benzoate drug combination
Izmenenie okislitel'nogo fosforilirovaniia pri deĭstvii kofein-benzoata natriia.