Comparative nephrotoxicities of high-dose netilmicin and tobramycin in rats.
The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days were compared in Fischer rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.
D000818:Animals; D000900:Anti-Bacterial Agents / Q000633:toxicity*; D005839:Gentamicins / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D007677:Kidney Function Tests; D008297:Male; D009336:Necrosis; D009428:Netilmicin / Q000633:toxicity*; D051381:Rats; D014031:Tobramycin / Q000633:toxicity*; D010130:p-Aminohippuric Acid / Q000378:metabolism
D000900:Anti-Bacterial Agents; D005839:Gentamicins; D009428:Netilmicin; D014031:Tobramycin; D010130:p-Aminohippuric Acid