Permeability of hyaluronic acid solutions. The effects of matrix concentration, calcium, and pH.
The permeability of hyaluronic acid solutions was measured in a chamber closed at each end of semi-permeable membranes. Permeability was strongly concentration dependent below 1.0 gm% hyaluronic acid. Small changes in the ionic environment of 1.0 gm% hyaluronic acid solutions also altered permeability. The permeability of such solutions decreased by a factor of 4.7 in the presence of as little as 5 mM calcium ion and showed optimum permeability at pH 7.0. The pH optimum was not noted in hyaluronic acid preparations known to contain only small amounts of protein.
D002118:Calcium / Q000494:pharmacology; D005260:Female; D005374:Filtration / Q000295:instrumentation; D006801:Humans; D006820:Hyaluronic Acid; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D008851:Micropore Filters; D008956:Models, Chemical; D009994:Osmolar Concentration; D009995:Osmosis; D010539:Permeability; D011247:Pregnancy; D012996:Solutions; D014470:Umbilical Cord
D008567:Membranes, Artificial; D012996:Solutions; D006820:Hyaluronic Acid; D002118:Calcium