title: [Excretion of pethidine in mother's milk (author's transl)].
abstract: Each of nine nursing mothers received one single intramuscular injection of 50 mg pethidine (Dolcontral), between the third and eighth days from childbirth. The highest pethidine concentration, 0.526 mumol/l or 0.13 microgrms/ml, was recorded from breast milk, two hours from application. After 24 hours, the concentration had dropped to 0.081 mumol/l or 0.02 microgram/ml. - The milk-serum quotient was in excess of 1.0. A correlation was found to exist between pethidine concentrations in the serum, on the one hand, and those in mother's milk, on the other. - One single application of Dolcontral is not expected to be of harmful effect on the newborn.
mesh_terms: D001682:Biological Availability; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D008614:Meperidine / Q000008:administration & dosage / Q000032:analysis* / Q000378:metabolism; D008895:Milk, Human / Q000032:analysis*; D049590:Postpartum Period; D011247:Pregnancy; D013997:Time Factors
chemical_list: D008614:Meperidine
vernacular_title: Ausscheidung von Pethidin durch die Muttermilch.