[Effects of strophanthin, mefenamic acid and dexamethasone on the inflammatory and reparative processes in the heart in experimental myocarditis].
In isadrin-induced myocarditis, the rat heart shows an increase in the activity of acid phosphatase, glucose-6-phosphate dehydrogenase. The heart weight also rises, whereas ATPase activity and magnesium content fall. Under these conditions strophanthin produces a marked decrease in acid phosphatase activity, stimulates the activity of glucoso-6-phosphate dehydrogenase, and demonstrates a tendency to increasing the activity of ATP-splitting enzymes, to reducing the activity of ATP-synthetase, and to the recovery of the magnesium content. Mefenamic acid and dexamethasone also decrease the activity of acid phosphatase but this decrease is less pronounced as compared with that induced by strophanthin. They exhibit the same tendency to the inhibition of glucoso-6-phosphate dehydrogenase. Mefenamic acid affects the remaining parameters similarly to strophanthin, while dexamethasone inhibits them.
D000818:Animals; D003907:Dexamethasone / Q000627:therapeutic use*; D004353:Drug Evaluation, Preclinical; D004734:Energy Metabolism / Q000187:drug effects; D004789:Enzyme Activation / Q000187:drug effects; D006321:Heart / Q000187:drug effects*; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008528:Mefenamic Acid / Q000627:therapeutic use*; D009205:Myocarditis / Q000188:drug therapy* / Q000378:metabolism; D051381:Rats; D013328:Strophanthins / Q000627:therapeutic use*
D013328:Strophanthins; D008528:Mefenamic Acid; D003907:Dexamethasone; D008274:Magnesium
Vliianie strofantina, mefenamovoĭ kisloty i deksametazona na vospalitel'no-reparativnye protsessy v serdtse pri éksperimental'nom miokardite.