Selective hypoplasia of pelvic bone marrow.
6 patients with thrombocytopenia and anaemia had fatty marrow replacement at the site of an iliac crest. 52Fe scans showed marked abnormalities of bone marrow distribution. Particularly, the uptake of radioiron into the pelvis was almost absent. The sternal marrow was cellular. Studies of the bone marrow which included cytology, histology and electron microscopy failed to reveal why the pelvic marrow was aplastic. Occasional vascular lesions could not seen in the iliac crest bone marrow sections. The cellular morphology showed slight maturation abnormalities. Ferrokinetics were consistent with erythroid marrow hypoplasia. The pelvic and sternal marrow cellularity in patients with pancytopenia may not be representative of the cellularity of the whole marrow, and the pelvic marrow especially may be prone to aplasia.
D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000473:pathology*; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology*; D003114:Colony-Forming Units Assay; D004920:Erythropoiesis; D005260:Female; D006801:Humans; D007085:Ilium / Q000473:pathology; D007501:Iron / Q000378:metabolism; D007504:Iron Radioisotopes; D008297:Male; D008875:Middle Aged; D013249:Sternum / Q000166:cytology; D013921:Thrombocytopenia / Q000473:pathology*
D007504:Iron Radioisotopes; D007501:Iron