Distribution of radioactivity in rats injected with L-14C methionine as studied by whole body autoradiography.
14C-L methionine was given intraperitoneally to rats. The delivered dose was 2.7 mg . kg-1 and the injected activity was 100 microCi . kg-1. Whole body autoradiography was performed on all rats. We noted the highest uptake of radioactivity in the liver and the pancreas. In the liver, there was an accumulation of radioactivity which occurs in the two hours after the injection. In the pancreas, both exocrine and endocrine portions were labelled. All the other organs were labelled but the highest activities are found in high protein turn-over tissues (glands, bone-marrow, spleen). This suggests that methionine is rapidly incorporated into proteins which can explain the persistence of radioactivity in the body of rats injected with this amino acid.
D000818:Animals; D001345:Autoradiography; D002490:Central Nervous System / Q000378:metabolism; D004064:Digestive System / Q000378:metabolism; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D008715:Methionine / Q000097:blood / Q000378:metabolism*; D010179:Pancreas / Q000378:metabolism*; D051381:Rats
D008715:Methionine