title: [Antitumor cytotoxins in the early stages of liver carcinogenesis].
abstract: By the cellular cytotoxic test in vitro it was demonstrated that lymphocytes of the spleen and lymphnodes from normal mice C3HA and mice given a carcinogen--o-AAT during 30 days show a cytotoxic effect on the hepatoma 22a culture. It was found that the cytotoxic activity of splenic and lymphnode lymphocytes in mice, given the carcinogen for 60 days, was reduced. In a number of experiments splenic lymphocytes of these mice were found to stimulate the hepatoma 22a cells growth in vitro.
mesh_terms: D000818:Animals; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D003603:Cytotoxins / Q000276:immunology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced* / Q000276:immunology; D008214:Lymphocytes / Q000276:immunology; D051379:Mice; D008809:Mice, Inbred C3H; D013997:Time Factors; D009762:o-Aminoazotoluene
chemical_list: D003603:Cytotoxins; D009762:o-Aminoazotoluene
vernacular_title: Protivoopukholevye tsitotoksiny na rannikh stadiiakh gepatokantserogeneza.