Synthesis and evaluation of substituted quinazolone derivatives for antibacterial, antifungal, and antiacetylcholinesterase activities.
The synthesis of new 6-bromo- and 6,8-dibromo-2-[N-(2'-alkyl-1',3',4'-thiadizol-5'-yl)carbamoylmethylthio] -3-aryl/cyclohexyl-4-(3H)-quinazolones is described. The synthesis derivatives were screened for antibacterial, antifungal, and antiacetylcholinesterase activities in vitro. Most of the compounds exhibited significant biological activity. The relation between their biological activity and chemical structure was studied.
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D002800:Cholinesterase Inhibitors; D005658:Fungi / Q000187:drug effects; D011799:Quinazolines / Q000138:chemical synthesis / Q000494:pharmacology*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000935:Antifungal Agents; D002800:Cholinesterase Inhibitors; D011799:Quinazolines