[Effects of sulpiride isomers in the control of blood pressure in man].
The effects of d-Sulpiride (25 mg i.v.) and 1-Sulpiride (25 mg i.v.) administration in the control of arterial blood pressure (ABP) and PRL-GH secretion have been analyzed in five normal male volunteers. It was observed a quite different action on ABP, 1-Sulpiride causing a long lasting hypotension and d-Sulpiride a short-lived hypertension. The correlation between ABP, heart rate and PRL-GH levels suggests a probable central cation for 1-Sulpiride and a possible peripheral action for d-Sulpiride effects on ABP.
D001794:Blood Pressure / Q000187:drug effects*; D013006:Growth Hormone / Q000097:blood; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D011388:Prolactin / Q000097:blood; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D013469:Sulpiride
D013469:Sulpiride; D011388:Prolactin; D013006:Growth Hormone
"Azione degli isomeri della sulpiride nel controllo della pressione arteriosa nell'uomo".