title: Transient concanavalin A-binding glycoproteins of the parallel fibres of the developing rat cerebellum: evidence for the destruction of their glycans.
abstract: The lifetime of the glycoprotein glycans of the rat cerebellum was followed in the 2nd and 3rd weeks of postnatal age, after injection of labelled glucosamine. It appears that a particular class of glycans binding to Concanavalin A synthesized at an early age has a short lifetime. These results indicate that the glycans of the concanavalin A-binding glycoproteins abundant on the newly formed parallel fibres are rapidly degraded between the 14th and the 18th postnatal day.
mesh_terms: D000375:Aging; D000818:Animals; D002250:Carbon Radioisotopes; D002352:Carrier Proteins / Q000302:isolation & purification / Q000378:metabolism*; D002531:Cerebellum / Q000254:growth & development* / Q000378:metabolism; D005944:Glucosamine / Q000378:metabolism; D006023:Glycoproteins / Q000302:isolation & purification / Q000378:metabolism*; D007700:Kinetics; D011134:Polysaccharides / Q000378:metabolism*; D051381:Rats; D011952:Receptors, Concanavalin A / Q000302:isolation & purification / Q000378:metabolism*
chemical_list: D002250:Carbon Radioisotopes; D002352:Carrier Proteins; D006023:Glycoproteins; D011134:Polysaccharides; D011952:Receptors, Concanavalin A; C027774:concanavalin A-binding glycoproteins; D005944:Glucosamine