Removal of corpora lutea in pregnant goats: effect of intrauterine indomethacin.
Removal of corpora lutea from seven goats during late pregnancy (122 to 129 days) resulted in an abrupt decline in uterine venous plasma progesterone concentrations within 10 min and abortion after a mean interval of 29.88 +/- 1.64 (SD) h. Abortion was preceded by a significant increase in uterine venous plasma PGF concentration either before or coincident with palpable cervical softening. Intrauterine, extra-fetal administration of indomethacin, as a single dose, in a further five lutectomised goats significantly prolonged the interval to abortion and delayed both cervical ripening and the increase in plasma PGF.
D000028:Abortion, Induced / Q000662:veterinary; D000818:Animals; D002584:Cervix Uteri / Q000502:physiology; D003338:Corpus Luteum / Q000601:surgery*; D004958:Estradiol / Q000097:blood; D004970:Estrone / Q000097:blood; D005260:Female; D006041:Goats / Q000502:physiology*; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology*; D011247:Pregnancy; D011270:Pregnancy, Animal; D011374:Progesterone / Q000097:blood; D011460:Prostaglandins F / Q000097:blood; D014599:Uterus / Q000187:drug effects*
D011460:Prostaglandins F; D004970:Estrone; D011374:Progesterone; D004958:Estradiol; D007213:Indomethacin