The effect of oral calcium carbonate administration on serum lipoproteins of children with familial hypercholesterolaemia (type II-A).
The effect of oral calcium carbonate on serum lipoprotein concentrations was tested in 50 children with familial hypercholesterolemia (type II-A) consuming a low cholesterol high polyunsaturated fat diet, using a cross-over design versus a placebo. Cholesterol was measured in serum and in the individual lipoprotein density classes. Serum apolipoprotein B (the protein moiety of low density lipoprotein) and apolipoprotein A-I (the main protein of high density lipoprotein) were measured by specific immunoassays. Calcium carbonate treatment induced only a slight increase in serum apolipoprotein A-I (+ 4%) and a slight decrease in low density lipoprotein cholesterol (-4%), both changes being significant at the P = 0.05 level.
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001053:Apolipoproteins / Q000097:blood; D002119:Calcium Carbonate / Q000008:administration & dosage* / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D002784:Cholesterol / Q000097:blood; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy*; D008074:Lipoproteins / Q000097:blood*
D001053:Apolipoproteins; D008074:Lipoproteins; D002784:Cholesterol; D002119:Calcium Carbonate