Selective inhibition by amezinium of intraneuronal monoamine oxidase.
Intra- and extraneuronal compartments of rat hearts were selectively labelled by perfusion with 3H-noradrenaline in the presence of corticosterone 87 microM or cocaine 30 microM, respectively. The subsequent outflow of 3H-compounds was examined. As little as 1 nM amezinium diminished the outflow of intraneuronally formed 3H-DOPEG. This effect was antagonized by cocaine. Amezinium 1 microM was necessary to diminish the outflow of extraneuronally formed 3H-DOPEG. This effect was not counteracted by corticosterone. The results indicate that amezinium is both a potent and, at low concentrations, selective inhibitor of intraneuronal MAO.
D000818:Animals; D003042:Cocaine / Q000494:pharmacology; D003345:Corticosterone / Q000494:pharmacology; D005260:Female; D008996:Monoamine Oxidase Inhibitors; D009206:Myocardium / Q000378:metabolism; D009474:Neurons / Q000201:enzymology*; D011724:Pyridazines / Q000494:pharmacology*; D051381:Rats; D013566:Sympathomimetics / Q000494:pharmacology*
D008996:Monoamine Oxidase Inhibitors; D011724:Pyridazines; D013566:Sympathomimetics; D003042:Cocaine; C027784:amezinium; D003345:Corticosterone