title: Lectin binding sites in the choroid plexus and choroid plexus papillomas.
abstract: The surface of the cells of the normal choroid plexus and of the plexus papillomas is coated by sialomucopolysaccharides, containing substances which are positively stained with the colloidal iron (Hale-) reaction. After pretreatment with neuraminidase sialic acid is removed rendering the membrane negative to the Hale reaction. Using FITC- or rhodamine-labelled PNA (Arachis hypogaea) and RCA (Rhicinus communis) lectins specific receptors are demonstrable. The identity of these distinct oligosaccharides containing receptors with the Thomsen-Friedenreich antigens suggests the possibility of an immunologic significance, e. g. in bacterial or viral infections of the brain. The application of histochemical techniques seem suitable to clarify the differential-diagnosis between choroid plexus papillomas on the one hand and metastasis of carcinoma and papillary ependymomas on the other hand.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000032:analysis* / Q000276:immunology; D002648:Child; D002831:Choroid Plexus / Q000032:analysis* / Q000276:immunology; D005260:Female; D006801:Humans; D037102:Lectins / Q000032:analysis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010212:Papilloma / Q000032:analysis* / Q000276:immunology; D011975:Receptors, Mitogen / Q000032:analysis* / Q000276:immunology
chemical_list: D037102:Lectins; D011975:Receptors, Mitogen