[Plasma level of etidocaine within the first two hours after axillary plexus block in healthy adults and patients with renal insufficiency (author's transl)].
The plasma level of etidocaine was studied within the first two hours of axillary block in 7 patients with renal insufficiency and 7 healthy adults. After 15-20 min the maximum of plasma concentration was found in the group with renal failure and after 30-45 min in the healthy adults. 30 min after the block the plasma level was 1,26 +/- 0,62 mug/ml in the ill patients and only 0,73 +/- 0,31 in the normal group. Using a mathematical model the ratio of permeation into the blood is significantly higher in the group with renal failure than in the healthy adults. The main reason for these results seems to be the acidosis, which is often combined with renal insufficiency. The meaning of these results for regional anaesthesia in patients like these is discussed.
D000083:Acetanilides / Q000097:blood*; D000328:Adult; D000368:Aged; D001917:Brachial Plexus; D005041:Etidocaine / Q000097:blood*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D014018:Tissue Distribution
D000083:Acetanilides; D005041:Etidocaine
Plasmakonzentration von Etidocain in den ersten zwei Stunden nach axillärer Blockade bei Gesunden und bei Patienten mit Niereninsuffizienz.