Effect of naftidrofuryl on high energy phosphates, glycogen, lactate and pyruvate in mouse hearts during asphyxia and post-asphyctic recovery.
The effect of naftidrofuryl (40 micrograms/g i.p.) on the ATP, phosphocreatine (PC), glycogen, lactate and pyruvate contents of the heart during respiratory arrest and postanoxic recovery was studied in mice. Naftidrofuryl increased he PC-content of the heart of normal mice. It did not prevent the metabolic changes brought about by 1 min anoxia but accelerated the post anoxic recovery of the depleted PC-content on account of delayed replenishment of the reduced glycogen stores. The changes in the ATP, lactate and pyruvate contents were not affected.
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001237:Asphyxia / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D005663:Furans / Q000494:pharmacology*; D006003:Glycogen / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D007773:Lactates / Q000378:metabolism; D008297:Male; D051379:Mice; D009206:Myocardium / Q000378:metabolism*; D009257:Nafronyl / Q000494:pharmacology*; D010710:Phosphates / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D011773:Pyruvates / Q000378:metabolism
D005663:Furans; D007773:Lactates; D010710:Phosphates; D011773:Pyruvates; D010725:Phosphocreatine; D009257:Nafronyl; D000255:Adenosine Triphosphate; D006003:Glycogen