[Plasma cortisol levels after acute administration of baclofen].
Plasma cortisol levels after acute administration of Baclofen, a Gaba agonist drug, were evaluated in eight healthy volunteer subjects. After 10 mg. of such drug, cortisol levels did not change appreciably. On the contrary after 20 mg. Baclofen elicited a rise in cortisol plasma levels. Baclofen increases striatal levels of dopamine. Therefore it is possible that metabolic effects of the drug are a consequence of increased levels of dopamine.
D001418:Baclofen / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*
D001418:Baclofen; D006854:Hydrocortisone
Cortisolemia dopo somministrazione acuta di baclofene.