[The antimycotic activity of acyl derivaties of 2-oximino-1,3-benzodithiol].
A series of esters of 2-oximino-1,3-benzodithiol [substances (II leads to XV)] was prepared and tested for antifungal activity in vitro. The substances were obtained by condensation of 2-oximino-1,3-benzodithiol with suitable acylation agents. The fungistatic activity of the products was tested in vitro against the four strains: Candida albicans, Candida tropicalis, Saccharomyces cerevisiae and Trichophyton mentagrophytes. The results reported in the Table I show the interesting antimycotic activity observed for 2-oximino-1,3-benzodithiol, which is apparently connected with the presence of a free oximino group.
D000935:Antifungal Agents / Q000138:chemical synthesis*; D055598:Chemical Phenomena; D002621:Chemistry; D005658:Fungi / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis*; D008826:Microbial Sensitivity Tests; D010091:Oximes / Q000138:chemical synthesis
D000935:Antifungal Agents; D006571:Heterocyclic Compounds; D010091:Oximes
Sull'attività antimicotica di acilderivati del 2-ossimino-1,3-benzoditiolo.