title: Studies on organ-specific alkaline phosphatases in relation to their diagnostic value.
abstract: The role of pH on tissue alkaline phosphatases have been investigated in different human tissues. Different isoenzymes have been observed in different organs. Bone and liver were similar in having the isoenzymes optimally active at 9.4 and pH 9.9. The kidney has a single alkaline phosphatase optimally active at pH 9.2, while the adrenal gland has two isoenzymes of optimum pH 9.2 and 10.1. Intestinal alkaline phosphatase was optimally active at pH 9.7.
mesh_terms: D000311:Adrenal Glands / Q000201:enzymology; D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism*; D001842:Bone and Bones / Q000201:enzymology; D004796:Clinical Enzyme Tests; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000201:enzymology; D007527:Isoenzymes / Q000378:metabolism*; D008099:Liver / Q000201:enzymology; D009928:Organ Specificity; D014018:Tissue Distribution
chemical_list: D007527:Isoenzymes; D000469:Alkaline Phosphatase