title: Further studies on endocrine factors and the growth and spread of B16 melanoma.
abstract: An intramuscularly inoculated B16 melanoma line grew or slowly in normal female mice than in either those following oophorectomy and/or estrogen therapy, or in male syngenic C57BL6J mice following orchidectomy and/or estrogen therapy. The number of metastases in estrogen-treated mice was higher than in the other groups.
mesh_terms: D000818:Animals; D002369:Castration; D004967:Estrogens / Q000494:pharmacology / Q000502:physiology*; D005260:Female; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D008545:Melanoma / Q000378:metabolism* / Q000473:pathology; D051379:Mice; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation; D009376:Neoplasms, Hormone-Dependent; D012737:Sex Factors; D013997:Time Factors
chemical_list: D004967:Estrogens