title: [Changes in the reactive properties of the body under anesthesia against a background of aspartic acid premedication].
abstract: It was shown in acute experiments on mice and dogs that aspartic acid and its sodium salt administered 15-30 minutes prior to ether and hexenal anesthesia prolong the animals' life span by 42.2-99.9% compared to control given an isotonic solution of sodium chloride. The stabilizing action of the aspartate is accounted for by its effect on the reactive properties of the central nervous system, particularly on the new cortex, old cortex, archicortex and circulation. This effect is also associated with the increased oxygen tension in brain tissues, with increased heart contractions and slowing down of their rhythm.
mesh_terms: D000758:Anesthesia; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D002490:Central Nervous System / Q000187:drug effects*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004986:Ether; D006591:Hexobarbital / Q000494:pharmacology; D008297:Male; D051379:Mice; D011229:Preanesthetic Medication; D013997:Time Factors
chemical_list: D004986:Ether; D001224:Aspartic Acid; D006591:Hexobarbital
vernacular_title: Izmenenie reaktivnykh svoĭstv organizma v usloviiakh narkoza na fone premedikatsii asparaginovoĭ kislotoĭ.