Influx of gamma-aminobutyric acid and alpha-aminoisobutyric acid into mouse cerebrum slices incubated in a pyruvate medium with or without added glucose or glucose analogues compared with influx from a glucose medium.
Concentrative influx of gamma-aminobutyric acid (GABA) and alpha-amino-isobutyric acid (AIB) into incubated mouse cerebrum slices is decreased when pyruvate is substituted for glucose. Influx of GABA from pyruvate medium is not increased by presence of glucose, 2-deoxy-D-glucose (2-DOG), or 3-O-methyl-D-glucose (3-O-MeG). Influx of AIB is restored to the rate from glucose medium if 2-DOG is present initially, but is not restored if 2-DOG is added with AIB. Influx is not restored if 3-O-MeG is present initially, but is restored if 3-O-MeG is added with AIB. Influx is restored if glucose is present initially or is added with AIB.
D000621:Aminoisobutyric Acids / Q000378:metabolism*; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D003837:Deoxy Sugars / Q000494:pharmacology*; D003847:Deoxyglucose / Q000494:pharmacology*; D005947:Glucose / Q000494:pharmacology*; D007700:Kinetics; D008757:Methylglucosides / Q000494:pharmacology*; D008759:Methylglycosides / Q000494:pharmacology*; D051379:Mice; D011773:Pyruvates / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D000621:Aminoisobutyric Acids; D003837:Deoxy Sugars; D008757:Methylglucosides; D008759:Methylglycosides; D011773:Pyruvates; D005680:gamma-Aminobutyric Acid; D003847:Deoxyglucose; D005947:Glucose