[Experimental investigation on possibilities of regeneration of the immunity in old animals (author's transl)].
The effect of Levamisol, potassium polyadenylate, complete Freund's adjuvant and "antigen premunition" on the primary and secondary immunological response to sheep erythrocytes as well as the reaction of "graft versus host" were tested on mice of the CBA strain belonging to various age groups. The greatest stimulation effect in both types of response, i.e. humoral and cellular, was produced by "premunition". Levasimole clearly increased the reaction of "graft versus host", while the humoral response was weakened. The application of potassium polyadenylate produced a weaker stimulus to the response to sheep erythrocytes, and it was not effective in the response of "graft versus host". The complete Freund's adjuvant had no influence whatsover on the humoral immune response in old mice.
D000249:Adenosine Monophosphate / Q000494:pharmacology; D000375:Aging; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects*; D005620:Freund's Adjuvant / Q000494:pharmacology; D006087:Graft vs Host Reaction / Q000187:drug effects; D007111:Immunity, Cellular / Q000187:drug effects*; D007978:Levamisole / Q000494:pharmacology*; D051379:Mice; D008808:Mice, Inbred CBA; D013154:Spleen / Q000276:immunology
D007978:Levamisole; D000249:Adenosine Monophosphate; D005620:Freund's Adjuvant
Experimentelle Untersuchungen der Reparationsmöglichkeit der Immunität bei alten Tieren.