[Myasthenia gravis syndrome following administration of d-penicillamine (author's transl)].
The authors report a case of myasthenia gravis syndrome appearing six months after the start of d-Penicillamine treatment for rheumatoid polyarthritis and disappearing rapidly and definitively after cessation of that treatment. In connection with the case the authors review some forty similar cases in the literature and consider the principal clinical, electrophysiological and immunological aspects. They also discuss the etiopathogenic hypotheses and treatment of this iatrogenic complication.
D001172:Arthritis, Rheumatoid / Q000188:drug therapy; D001323:Autoantibodies / Q000032:analysis; D004558:Electric Stimulation; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000139:chemically induced* / Q000503:physiopathology; D009469:Neuromuscular Junction / Q000503:physiopathology; D010396:Penicillamine / Q000009:adverse effects*; D011950:Receptors, Cholinergic / Q000276:immunology
D001323:Autoantibodies; D011950:Receptors, Cholinergic; D010396:Penicillamine
Syndrome myasthénique secondaire à l'administration de d-pénicillamine.