Inhibition by neurotoxic phospholipases A2 of synaptosomal uptake of gamma-aminobutyric acid.
A comparison has been made of the abilities of several neurotoxic and nontoxic phospholipases A2 from snake venoms to inhibit the intake of gamma-aminobutyric acid into synaptosomes from rat cerebral cortex. The neurotoxic phospholipase A2 inhibited GABA uptake more than the nontoxic enzymes did. However, there was a poor correlation between the measured specific enzyme activity of a phospholipase A2 and its ability to inhibit the uptake of GABA.
D000818:Animals; D002038:Bungarotoxins / Q000494:pharmacology; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D003439:Crotoxin / Q000494:pharmacology; D066298:In Vitro Techniques; D009498:Neurotoxins / Q000494:pharmacology*; D010169:Palmitic Acids / Q000032:analysis; D010740:Phospholipases / Q000494:pharmacology*; D010741:Phospholipases A / Q000494:pharmacology*; D054467:Phospholipases A2; D051381:Rats; D013574:Synaptosomes / Q000187:drug effects* / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D002038:Bungarotoxins; D009498:Neurotoxins; D010169:Palmitic Acids; D005680:gamma-Aminobutyric Acid; D003439:Crotoxin; D010740:Phospholipases; D010741:Phospholipases A; D054467:Phospholipases A2