[Prooxidant effect of alpha-tocopherol on essential fatty acids in aqueous media].
Linoleic, linolenic and arachidonic acids, dispersed at a concentration of 2.5 x 10-3 M in an aqueous media pH 7.3, exhibited increasing of their autoxidation rate in presence of 1.5 x 10-5M alpha-tocopherol or more. Cosidering linolenic and arachidonic acids, prooxidant effect increased with alpha-tocopherol level while for linoleic acid this effect was similar with all alpha-tocopherol concentrations. During the prooxidant reaction, alpha-tocopherol was rapidly oxidized. Its oxidation rate depended on hydroperoxides level. It was the most important in presence of arachidonic acid. After 24 hours, alpha-tocopherol was completly oxidized whatever its initial concentration and the type of the fatty acid. Two oxidation products have been identified : alpha-tocopherylquinone for the most part and a dimer of alpha-tocopherol which was detected at the beginning of the reaction.
D001095:Arachidonic Acids; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D008042:Linolenic Acids; D008054:Lipid Peroxides; D009994:Osmolar Concentration; D010084:Oxidation-Reduction; D014810:Vitamin E / Q000031:analogs & derivatives; D014867:Water; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D001095:Arachidonic Acids; D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D008042:Linolenic Acids; D008054:Lipid Peroxides; D014867:Water; D014810:Vitamin E; C024838:alpha-tocopherol quinol; D024502:alpha-Tocopherol
Etude de l'effet prooxygène de l' alpha-tocophérol sur les acides gras essentiels en milieu aqueux.