[3H-thymidine incorporation under endocrine influence and hormone receptor content of human mammary carcinoma (author's transl)].
The effect of medroxyprogesterone acetate, oestradiol-17 beta and testolactone on 3H-thymidine incorporation in human mammary carcinoma was studied in vitro. 54% of the tumours reacted to medroxyprogesterone, while testolactone and oestradiol-17 beta changed 3H-thymidine incorporation in 45.1 and 41.3%, respectively. Both inhibition and the in vivo undesirable stimulation of 3H-thymidine incorporation was observed. No relation could be established between oestrogen receptor content and reaction of the mammary carcinoma to oestradiol-17 beta. On the other hand, the gestagen receptor content and the reaction of the mammary carcinoma to medroxyprogesterone acetate correlated significantly (P < 0.001). This underlines the increasing significance of the gestagen receptor in the selective endocrine treatment of mammary carcinoma.
D001943:Breast Neoplasms / Q000032:analysis / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D006801:Humans; D008525:Medroxyprogesterone / Q000494:pharmacology*; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D013738:Testolactone / Q000494:pharmacology*; D013936:Thymidine / Q000378:metabolism*
D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D004958:Estradiol; D013738:Testolactone; D008525:Medroxyprogesterone; D013936:Thymidine
3H-Thymidin-Inkorporation unter endokrinem Einfluss und Hormonrezeptorgehalt menschlicher Mammakarzinome.