Induction of chromosomes aberrations, sister chromatid exchanges, and specific locus mutations in Chinese hamster ovary cells by 5-bromodeoxyuridine.
The induction of cytotoxicity, growth inhibition, specific locus mutations, and cytological alterations such as micronuclei, chromosome/chromatid aberrations, and sister chromatid exchanged by 5-bromodeoxyuridine (BudR) in Chinese hamster ovary cells was determined. BudR shows concentration-dependent increases in cytological alterations over the range of 5-500 muM, but it is mutagenic only at concentrations greater than 50 muM.
D000818:Animals; D001973:Bromodeoxyuridine / Q000494:pharmacology*; D002455:Cell Division; D002460:Cell Line; D002470:Cell Survival; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus / Q000235:genetics; D003434:Crossing Over, Genetic; D004305:Dose-Response Relationship, Drug; D005260:Female; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D008940:Mitotic Index; D009154:Mutation; D010053:Ovary; D012854:Sister Chromatid Exchange
D007041:Hypoxanthine Phosphoribosyltransferase; D001973:Bromodeoxyuridine