Effects of alcohol and hyperthermia on normal and leukemic lymphocytes.
By the method of viable lymphocyte counts, ethanol was found (1) to have a cytocidal effect on normal and leukemic lymphocytes; (2) to be more toxic to leukemic than to normal lymphocytes; (3) to be synergistic with hyperthermia, and (4) to decrease the critical temperature of normal lymphocytes from 43 to 41.5 degree C.
D000438:Alcohols / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D000431:Ethanol / Q000494:pharmacology; D006358:Hot Temperature; D006801:Humans; D066298:In Vitro Techniques; D007928:Lethal Dose 50; D007945:Leukemia, Lymphoid / Q000097:blood* / Q000473:pathology; D007958:Leukocyte Count; D008214:Lymphocytes / Q000187:drug effects* / Q000473:pathology; D008297:Male; D013997:Time Factors
D000438:Alcohols; D000431:Ethanol