title: Age-related changes in the auditory evoked brainstem potentials of albino and pigmented guinea pigs.
abstract: The auditory evoked brainstem responses of guniea pigs in two age groups were recorded and examined for evidence of age-dependent changes at peripheral stations in the auditory pathway. Because pigmented guinea pigs have been found to be less sensitive to sounds than albinos, both groups were included in this study. Old and young animals did not differ in response latency or in the conduction times associated with the individual potentials. By contrast, the amplitudes of the brainstem responses to high-frequency stimuli were distinctly reduced in old guinea pigs, with no difference in the dynamic of the amplitude between the two age groups. Within each age group, albino and pigmented animals resembled one another in all parameters studied. The effect of the aging process at the peripheral stations of the auditory pathway is discussed in the light of these results.
mesh_terms: D000375:Aging; D000417:Albinism / Q000503:physiopathology; D000818:Animals; D001306:Auditory Pathways / Q000502:physiology; D001309:Auditory Threshold; D001933:Brain Stem / Q000502:physiology*; D005072:Evoked Potentials, Auditory; D006168:Guinea Pigs; D010858:Pigmentation