Anaesthetic requirement in mice selectively bred for differences in ethanol sensitivity.
Anaesthetic requirements for nitrous oxide, enflurane and isoflurane were determined in mice selectively bred for their susceptibility ("long-sleep" mice) or resistance ("short-sleep" mice) to alcohol. Nitrous oxide and enflurane requirements, measured by the rolling-response test, were 34 and 20% greater, respectively, in short-sleep mice than in long-sleep mice. Although isoflurane requirement was 39% greater when measured by the tail-clamp test, it was not significantly different when measured by the rolling-response test. The greater anaesthetic requirement for short-sleep mice was not associated with a different synaptic membrane phospholipid, fatty acid or cholesterol composition.
D000769:Anesthesia, Inhalation; D000777:Anesthetics / Q000008:administration & dosage*; D000818:Animals; D004334:Drug Administration Schedule; D004737:Enflurane / Q000008:administration & dosage; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D007530:Isoflurane / Q000008:administration & dosage; D051379:Mice; D009609:Nitrous Oxide / Q000008:administration & dosage; D010743:Phospholipids / Q000032:analysis; D012018:Reflex / Q000187:drug effects; D012890:Sleep / Q000187:drug effects*; D013570:Synaptic Membranes / Q000032:analysis
D000777:Anesthetics; D010743:Phospholipids; D000431:Ethanol; D004737:Enflurane; D007530:Isoflurane; D009609:Nitrous Oxide