[Influence of the chemical structure of aromatic amines on alkaline elution of DNA].
The DNA damage induced by in vivo administration of: 2,4-dinitroaniline, ortho-toluidine and para-toluidine, was determined using alkaline filter elution of DNA. The target organs for ultimate carcinogens produced in mice appear to be the liver and the kidney. The damage was evident 4 hours after administration of a single dose of ortho- and para-toluidine. The values obtained after treatment with 2,4-dinitroaniline fall in the range of control mice.
D000814:Aniline Compounds / Q000494:pharmacology; D000818:Animals; D004247:DNA / Q000032:analysis / Q000378:metabolism*; D004136:Dinitrobenzenes / Q000494:pharmacology; D007668:Kidney / Q000187:drug effects; D008099:Liver / Q000187:drug effects; D008297:Male; D051379:Mice; D013329:Structure-Activity Relationship; D014052:Toluidines / Q000494:pharmacology*; D014462:Ultrafiltration
D000814:Aniline Compounds; D004136:Dinitrobenzenes; D014052:Toluidines; C010934:2,4-dinitroaniline; D004247:DNA
Influenza della struttura chimica delle ammine aromatiche sull'induzione della eluibilita' in alcali del DNA.