[Pharmacologic analysis of monoaminergic mechanisms of the medial hypothalamus in food-getting conditioned reflexes in rats].
In the study of food-procuring conditioned reflex in rats it was found that microinjection of noradrenaline and dopamine in the medial hypothalamus impedes its realization, prolonging the reflex latency, lowering its value and the number of conditioned food-procuring movements. The effects of catecholamines on food-procuring conditioned activity are specific and effectuated correspondingly via alpha-adrenoreceptors or receptors of the hypothalamic neurones sensitive to haloperidol and aminazine. Local administration of GABA to the hypothalamus prolongs the latency of the food-procuring conditioned reflex, but does not change its value and the number of conditioned food-procuring movements. The effect of GABA is not due to the effect on adreno- and dopamine receptors of the hypothalamus.
D000818:Animals; D001679:Biogenic Amines / Q000502:physiology*; D002746:Chlorpromazine / Q000494:pharmacology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004087:Dihydroergotamine / Q000494:pharmacology; D004298:Dopamine / Q000494:pharmacology; D005247:Feeding Behavior / Q000187:drug effects / Q000502:physiology*; D006220:Haloperidol / Q000494:pharmacology; D007031:Hypothalamus / Q000502:physiology*; D007033:Hypothalamus, Middle / Q000187:drug effects / Q000502:physiology*; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
D001679:Biogenic Amines; D012701:Serotonin; D004087:Dihydroergotamine; D005680:gamma-Aminobutyric Acid; D011433:Propranolol; D006220:Haloperidol; D002746:Chlorpromazine; D004298:Dopamine; D009638:Norepinephrine; D010646:Phentolamine
Farmakologicheskiĭ analiz monoaminergicheskikh mekhanizmov medial'nogo gipotalamusa v pishchedobyvatel'nykh uslovnykh refleksakh u krys.