Rosette-formation with mouse red blood cells in chronic lymphocytic leukemia and leukemic non-Hodgkin's lymphomas.
Peripheral blood lymphocytes from 30 patients with chronic lymphocytic leukemia (CLL) and 18 patients with malignant non-Hodgkin's lymphomas in leukemic phase were studied for rosette-formation with neuraminidase-treated mouse erythrocytes. The proportion of rosette-forming cells in CLL was significantly higher (p < 0.001) than in 12 cases of lymphoplasmacytoid malignant lymphoma (LPL). Our results suggest that this test may be a helpful method in the differentiation of CLL from leukemic LPL, which usually can not be distinguished by morphological criteria alone.
D000818:Animals; D003937:Diagnosis, Differential; D004912:Erythrocytes / Q000276:immunology; D006801:Humans; D007945:Leukemia, Lymphoid / Q000276:immunology*; D008223:Lymphoma / Q000276:immunology*; D051379:Mice / Q000276:immunology; D009439:Neuraminidase / Q000494:pharmacology; D012397:Rosette Formation
D009439:Neuraminidase