[Relapsing infections associated with high serum IgE levels Buckley's syndrome (author's transl)].
An 8-year old girl suffering from chronic relapsing staphylococcal skin infection since the first days of life was found to have extremely high (up to 26,500 units/ml) serum IgE levels and impaired polymorphonuclear chemotaxis. The other immunological tests appeared to be normal. There seemed to be a correlation between impaired chemotaxis and rise in IgE, the latter perhaps being related to a deficiency in some thymus-dependent lymphocyte functions.
D002634:Chemotaxis, Leukocyte; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications* / Q000276:immunology; D007073:Immunoglobulin E / Q000378:metabolism*; D007136:Immunoglobulins / Q000032:analysis; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D012397:Rosette Formation; D012874:Skin Diseases, Infectious / Q000150:complications* / Q000276:immunology; D013203:Staphylococcal Infections / Q000150:complications* / Q000276:immunology
D007136:Immunoglobulins; D007073:Immunoglobulin E
Infections récidivantes avec hypergammaglobulinémie E. Syndrome de Buckley.