Ultrastructural observations on the pathogenesis of aspirin-induced gastric erosions.
It is shown by transmission electron-microscopy that the first structural change in rats, following a dose of aspirin, is to the basement membrane of the endothelial cell of the capillary and post-capillary venule. This leads to the breakdown of small blood vessels before any other cytolytic effect. This is a focal effect and it is proposed that the erosion develops as an ischaemic infarct.
D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D002196:Capillaries / Q000187:drug effects / Q000648:ultrastructure; D004727:Endothelium / Q000187:drug effects / Q000648:ultrastructure; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects / Q000648:ultrastructure*; D008854:Microscopy, Electron; D051381:Rats; D013272:Stomach Diseases / Q000139:chemically induced* / Q000473:pathology
D001241:Aspirin