[The effects of probucol in man (author's transl)].
probucol is a new hypolipaemic agent which differs from similar drugs in current use by its chemical structurae and, probably, by its mode of action. Its predominantly cholesterol-lowering activity and its lack of serious side-effects make it a valuable product for the treatment of type IIa hypercholesterolaemia and of type II b mixed dyslipaemia. Whether or not it can be advantageously combined with other cholesterol-lowering agents in resistant hypercholesterolaemia remains to be determined. As with most drugs of this kind available at present, randomized prospective trials are required to demonstrate the efficacy of probucol in preventing atheroma and its safety in long-term usage.
D000924:Anticholesteremic Agents; D001161:Arteriosclerosis / Q000517:prevention & control; D001646:Bile / Q000187:drug effects; D002994:Clofibrate / Q000494:pharmacology; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000188:drug therapy; D010636:Phenols / Q000494:pharmacology*; D011341:Probucol / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use
D000924:Anticholesteremic Agents; D010636:Phenols; D002994:Clofibrate; D011341:Probucol
Effets du probucol chez l'homme.