Circulatory effects of intraduodenal acidification in the rat.
The effect of intraduodenal administration of 0.3 ml/100 g 0.1 N hydrochloric acid and of the i.v. injection of 0.3 U/100 g secretin on the regional circulation was investigated in rats with the radioactive microsphere method. Intraduodenal acid produced a threefold increase in duodenal blood flow, jejunal perfusion was doubled, the perfusion of pancreas increased significantly. There were no significant changes in cardiac output, renal, myocardial, gastric and ileal blood flow. Secretin administration was without effect on the circulation. The same hormone dose produced a tenfold increase in pancreas secretion but was without effect on bile output. It is concluded that in the rat low doses of secretion do not elicit mesenteric flow changes similar to those observed after duodenal acidification.
D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D004386:Duodenum / Q000098:blood supply*; D006851:Hydrochloric Acid / Q000008:administration & dosage / Q000494:pharmacology*; D007583:Jejunum / Q000098:blood supply*; D008297:Male; D010179:Pancreas / Q000098:blood supply*; D051381:Rats; D012039:Regional Blood Flow / Q000187:drug effects; D012633:Secretin / Q000494:pharmacology
D012633:Secretin; D006851:Hydrochloric Acid