Hearing loss and inner ear changes in a patient suffering from severe gentamicin ototoxicity.
The long-term histological effects of gentamicin ototoxicity could be studied in a human being in relation to the audiometric impairment. The possible sequence of degeneration of hair cells, supporting cells, nerve fibers, stria vascularis, spiral ganglion cells, and vascular supply is discussed.
D000328:Adult; D003051:Cochlea / Q000294:innervation / Q000473:pathology; D003638:Deafness / Q000139:chemically induced* / Q000473:pathology; D005260:Female; D005839:Gentamicins / Q000009:adverse effects*; D006198:Hair Cells, Auditory / Q000473:pathology; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D009412:Nerve Fibers / Q000648:ultrastructure; D013136:Spiral Ganglion / Q000473:pathology
D005839:Gentamicins