[Macrophage electrophoretic mobility inhibition test (MET) in immunological diagnosis of malignant lymphomas in Papio baboons].
Reactivity of lymphocytes from P. hamadryas monkeys carrying malignant lymphomas, directed against soluble antigens from allogeneic lymphomas, was investigated, using macrophage electrophoretic mobility (MEM) test. Twenty-three monkeys have been examined. Fourteen of them carried malignant lymphoma, including those with initial manifestations of malignant lymphoma, animals with a generalized process and those in the period of spontaneous remission, and 9 control animals (8 healthy baboons and one animal wih hepatoma). The macrophage electrophoretic mobility reduction higher than 10% was considered as positive. A positive reaction was observed in 78% of monkeys with malignant lymphoma. The positive MEM-test was noted already in the initial stage of the disease, and it remained positive in the period of spontaneous remission.
D000818:Animals; D002464:Cell Migration Inhibition / Q000379:methods; D002465:Cell Movement; D004586:Electrophoresis; D005260:Female; D008223:Lymphoma / Q000175:diagnosis* / Q000276:immunology; D008264:Macrophages / Q000502:physiology*; D008297:Male; D009374:Neoplasms, Experimental / Q000175:diagnosis; D010215:Papio
Metod tormozheniia elektroforeticheskoĭ podvizhnosti makrofagov (MEM-test) v immunodiagnostike zlokachrstvennykh limfom pavianov gamadrilov.