Glucocorticosteroid inhibition of intraocular proliferation after injury.
Perforating injuries were produced in the posterior segment of rabbit eyes. We studied the inhibitory effect of a slowly water-soluble corticosteroid, dexamethasone alcohol, on fibroblast growth. The treated group received a single intravitreal injection of 1 mg of the corticosteroid. The eyes were observed for four weeks. Transvitreal proliferation was significantly decreased and wound healing was delayed as compared to a control group. Inhibition of intraocular proliferation by high doses of intravitreally injected corticosteroid may be useful in the treatment of eyes with penetrating and perforating injuries.
D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology / Q000627:therapeutic use*; D005131:Eye Injuries / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D011817:Rabbits; D014945:Wound Healing / Q000187:drug effects*
D003907:Dexamethasone