[Modifications in the feeding behavior of the rat, induced by antimitotic drugs: effects of hydroxyurea].
The effects of Hydroxyurea treatment on food intake and on the self-selection between a protein free diet and a complete one are different from those observed during Cyclophosphamide and Mustine Hydrochloride treatment and appear to be similar to those observed during Methotrexate treatment; these may be referred exclusively to a toxic action of the drug on the liver and on the mucous membranes of digestive apparatus. The urea, a product of Hydroxyurea metabolism, does not seem to induce modifications on food intake both as to the quantitative and qualitative aspect.
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D006918:Hydroxyurea / Q000494:pharmacology*; D008297:Male; D051381:Rats
D006918:Hydroxyurea
Modificazioni del comportamento alimentare del ratto indotte da farmaci antimitotici: effetti dell'idrossiurea.