[Effect of structural analogs of gamma-aminobutyric acid on serotonin- and dopaminergic mechanisms].
The behavioral and biochemical effects of some GABA analogues (fenibut, fepiron and sodium hydroxybutyrate) were studied in 400 male albino mice. It was shown that although these compounds exert similar behavioral effects, their effects on brain monoamine metabolism are different. Fenibut largely stimulates the serotoninergic, fepiron inhibits the dopaminergic, while sodium hydroxybutyrate affects both the monoaminergic processes.
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D001679:Biogenic Amines / Q000378:metabolism; D008297:Male; D051379:Mice; D009949:Orientation / Q000187:drug effects; D011760:Pyrrolidinones / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000187:drug effects*; D012978:Sodium Oxybate / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology
D001679:Biogenic Amines; D011760:Pyrrolidinones; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D005680:gamma-Aminobutyric Acid; D012978:Sodium Oxybate
Vliianie nekotorykh strukturnykh analogov gamma-aminomaslianoĭ kisloty na serotoni- i dopaminergicheskie mekhanizmy.