[Determination of the availability of drugs from selected ointment bases by means of in vitro experiments. Part 4: The release of the local anaesthetic heptacaine (author's transl)].
The velocity of the release of heptacaine from selected ointment bases of the Csl. L. III has been studied in vitro with the aid of a dialysis technique. At three constant times the release rate could be brought in relation to the type of ointment base. Furthermore, the particle size of the suspended drug was estimated. It was found that the velocity of the release of heptacaine is influenced by its solubility in the outer phase of the ointment base.
D000779:Anesthetics, Local / Q000008:administration & dosage*; D001682:Biological Availability; D004058:Diffusion; D009823:Ointment Bases; D010880:Piperidines / Q000008:administration & dosage*
D000779:Anesthetics, Local; D009823:Ointment Bases; D010880:Piperidines; C013549:heptacaine
Bestimmung der Verfügbarkeit von Arzneistoffen aus ausgewählten Salbengrundlagen durch in-vitro-Versuche. 4. Mitteilung: Liberation des Lokalanästheticums Heptacain.