Acute urinary bladder toxicity of a polyurethane foam catalyst mixture: a possible new target organ for propionitrile derivative.
The toxicity of the mixture NIAX-ESN which contains 95% dimethylaminopropionitrile was evaluated in male rats. Large doses (2.0 ml/kg ip) rapidly produced CNS excitation followed by depression and death. The mixture (given orally as two doses of 0.31 or 0.62 ml/kg respectively) induced acute urinary bladder lesions in 3 days. The changes consisted of massive transmural edema, acute ulcers and inflammation and, occassionally hemorrhagic necrosis of the bladder wall.
D000629:Aminopropionitrile / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D000818:Animals; D007928:Lethal Dose 50; D008297:Male; D009092:Mucous Membrane / Q000473:pathology; D051381:Rats; D001743:Urinary Bladder / Q000473:pathology; D001745:Urinary Bladder Diseases / Q000139:chemically induced*
D000629:Aminopropionitrile; C019348:dimethylaminopropionitrile