Effect of bile acids on E rosette formation and PHA stimulation.
The effect of bile acids on E rosette formation and lymphocyte response to PHA was studied. Pooled conjugated and unconjugated bile acids decreased normal lymphocyte E rosette formation in vitro. This inhibition is related to bile acid concentration. Unconjugated bile acids induced a depression of PHA stimulation in comparison to controls. These findings suggest that bile acids can play a role in the depression of cellular immunity observed in patients with cholestasis.
D000818:Animals; D001647:Bile Acids and Salts / Q000494:pharmacology*; D006801:Humans; D008213:Lymphocyte Activation / Q000187:drug effects*; D010835:Phytohemagglutinins / Q000494:pharmacology*; D012397:Rosette Formation; D012756:Sheep / Q000276:immunology
D001647:Bile Acids and Salts; D010835:Phytohemagglutinins