title: [Drug fever caused by the antidepressive agent nomifensine (Alival)].
abstract: During 1979 4 patients were observed who developed short episodes of fever as high as 104 degrees F after oral intake of 25--100 mg nomifensine (Alival). In all four cases a clear fever spike was produced by reexposure to the drug. The reaction time was 4--6 hours. this drug-induced fever appeared initially 2--4 weeks after the commencement of Alival therapy. No other cause for the fever was identifiable. In one patient an allergic alveolitis was suspected to be a further reaction. In another patient a concomitant granulomatous hepatitis was possibly also due to this drug. It is probable that the febrile reactions have an allergic mechanism. Allergologic investigations have not yet been completed.
mesh_terms: D000368:Aged; D004342:Drug Hypersensitivity / Q000276:immunology; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D007546:Isoquinolines / Q000009:adverse effects*; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009627:Nomifensine / Q000009:adverse effects*
chemical_list: D007546:Isoquinolines; D009627:Nomifensine
vernacular_title: Arzneifieber auf das Antidepressivum Nomifensin (Alival).