[Radioimmunoassay of plasma cortisol and plasma cortisol circadian rhythm in external triamcinolone acetonide therapy].
Plasma cortisol levels in a four-point daily profile were measured by radioimmuno assay before and during treatment with corticoid-containing ointments (triamcinolone acetonide) in 21 patients with psoriasis, who had no endocrine disorders. In the pretreatment phase there were typical circadian fluctuations of the plasma cortisol concentrations. Already after two days of treatment a significant supression of adrenal function could be detected. This dysfunction increased during continuous treatment. In comparison with a fluorimetric method, the radioimmuno assay allowed a better differentiation. This could be due to a lack of specificity and to susceptibility to erroneous measurement of the fluorimetric method. We could also confirm that the distribution of plasma cortisol levels is not a linear but a logarithmic one. Considering the log-normal distribution different mean values and variances are obtained.
D000328:Adult; D002940:Circadian Rhythm / Q000187:drug effects*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood / Q000188:drug therapy; D011863:Radioimmunoassay; D014222:Triamcinolone Acetonide / Q000627:therapeutic use*
D014222:Triamcinolone Acetonide; D006854:Hydrocortisone
Radioimmunologische Bestimmung des Plasmakortisolspiegels und der Plasmakortisoltargesrhythmik bei externer Triamzinolonazetonidtherapie.