Effect of a psychoactive drug, trazodone, on prolactin secretion in man.
Administration of 50 mg trazodone, an antidepressant drug, in a single oral dose to 10 normal subjects of both sexes, aged 24--41, resulted in a significant (p less than 0.01) decrease of serum prolactin (PRL) values. The mean serum PRL levels were 8.9 +/- 2.2 ng/ml in basal conditions and 4.5 +/- 1.7 ng/ml 180 min after trazodone. Pretreatment with trazodone does not modify TRH-induced PRL release.
D000328:Adult; D005260:Female; D006801:Humans; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D010903:Pituitary Gland, Anterior / Q000378:metabolism*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D013997:Time Factors; D014196:Trazodone / Q000494:pharmacology*
D010879:Piperazines; D011388:Prolactin; D014196:Trazodone