[Platelet aggregation and prostaglandin turnover in man during defined linoleic acid supply with formula diets (author's transl)].
A report is given on changes of platelet aggregation and prostaglandin turnover during a cross-over experiment with six female volunteers being given a linoleic acid supply with formula diets of 0 g or 50 g daily. Collagen- and ADP-induced platelet aggregation was determined with a Borne-type aggregometer. Prostaglandin turnover was measured by analyzing the excretion of a joint derivative of prostaglandin metabolites, tetranorprostanedioic acid, in urine. With a linoleic acid supply of 50 g daily we found an increase of tetranorprostanedioic acid in urine, while platelet aggregation decreased. When the experimental subjects came from a conventional diet (linoleic acid intake 20 g daily) these changes were seen later than after a linoleic acid free formula diet. A linoleic acid-deficient formula diet caused a fall in prostaglandin turnover within 24 hr. ADP-induced platelet aggregation was unchanged after 1 week, while collagen-induced platelet aggregation was increased after 1 and 3 weeks of linoleic acid-deficient diet. These results clearly demonstrate the influence of nutrition on platelet aggregation.
D000328:Adult; D005260:Female; D005526:Food, Formulated; D006801:Humans; D008041:Linoleic Acids / Q000494:pharmacology*; D010974:Platelet Aggregation; D011453:Prostaglandins / Q000378:metabolism*; D011466:Prostanoic Acids / Q000652:urine
D008041:Linoleic Acids; D011453:Prostaglandins; D011466:Prostanoic Acids
Plättchenaggregation und Prostaglandinumsatz beim Menschen unter definierter Linolsäurezufuhr mit Formeldiäten.