Lack of effect of repeated electroconvulsive shock on [3H]spiroperidol and [2H]5-hydroxytryptamine binding and cholinergic parameters in rat brain.
Repeated electroconvulsive shock (ECS) administered on alternate days for 10 days produced no changes in rat striatal [3H]spiroperidol binding measured 24 h after the last shock compared to anaesthetised controls. Similarly, there was no change in while brain specific [3H]5-HT binding. Sodium-dependent high affinity [3H]choline uptake (HAUC) and ChAT were also unaltered in striatal and hippocampal samples following repeated ECS. Acute administration of Pentylenetetrazol did produce an increase in hippocampal HAUC immediately postictally. However, ECS (Xl) did not change HAUC measured 1 h postictally. An effect of halothane on HAUC was noted in these experiments indicating the importance of an evaluation of anaesthetic effects in ECS studies.
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D002090:Butyrophenones / Q000378:metabolism*; D002794:Choline / Q000378:metabolism*; D002795:Choline O-Acetyltransferase / Q000378:metabolism*; D004597:Electroshock; D008297:Male; D010433:Pentylenetetrazole / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000378:metabolism*; D013134:Spiperone / Q000378:metabolism*
D002090:Butyrophenones; D012701:Serotonin; D013134:Spiperone; D002795:Choline O-Acetyltransferase; D002794:Choline; D010433:Pentylenetetrazole