Permeability changes of erythrocytes and liposomes by 5-(n-alk(en)yl) resorcinols from rye.
5-(n-Alk(en)yl) resorcinols can induce potassium release from liposomes and erythrocytes. The results suggest that 5-(n-pentyl)resorcinol can induce a specific permeability to protons as well as to potassium and other small molecules. The highest permeability changes were found in the presence of 5-(n-pentadecyl)resorcinol and alkenyl resorcinols. Orcin and resorcin were without effect. The size of permeant as investigated by turbidity measurements indicated that Ca2+ and Mg2+ cannot pass through the alkyl resorcinol-modified membrane but can pass through the alkenyl resorcinol-modified membrane. It was observed that alkenyl resorcinol at a concentration of 15 microM induced not only potassium release but also lysis of erythrocytes.
D000818:Animals; D002463:Cell Membrane Permeability / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects*; D008081:Liposomes / Q000378:metabolism*; D009391:Nephelometry and Turbidimetry; D010713:Phosphatidylcholines / Q000378:metabolism; D011188:Potassium / Q000378:metabolism; D011817:Rabbits; D012118:Resorcinols / Q000494:pharmacology*; D012434:Secale
D008081:Liposomes; D010713:Phosphatidylcholines; D012118:Resorcinols; D011188:Potassium