Fetal striatal homotransplantation for Huntington's disease: first two case reports.
Based on the successful use of fetal striatal brain grafting in the restoration of striatal function in rat and nonhuman primate models of Huntington's disease, as well as on the evidence for the clinical potential of fetal brain grafting in the treatment of Parkinson's disease, homotopic fetal striatal homotransplantations were performed in two huntingtonians. Case 1 was a 37 year-old female with moderate to severe Huntington's disease of 9 years evolution; case 2 was a 29 year-old male with mild Huntington's disease of 5 years evolution. Using open microsurgery, each patient was implanted to the ventricular wall of the right caudate nucleus with both striata from a 13 week-old and a 12 week-old human fetus, respectively. Since surgery both patients were kept on cyclosporine A. Surgery produced no damaging effect to either patient. The time course of the neurological progression of their disease, spanning 33 months for case 1, and 16 months for case 2, reveal that the disease in both patients has progressed more slowly in relation to their preoperative state. Although presently it is not possible to determine to what extent, surgery has modified the course of their disease, or if it will continue to have an effect on it, these surgeries represent the first step towards the development of brain grafting for Huntington's disease.
D000328:Adult; D000818:Animals; D003342:Corpus Striatum / Q000637:transplantation*; D004195:Disease Models, Animal; D005260:Female; D016332:Fetal Tissue Transplantation; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D006816:Huntington Disease / Q000601:surgery*; D008297:Male; D010375:Pedigree; D051381:Rats; D014184:Transplantation, Homologous