D-dimer improves the prognostic value of combined clinical and laboratory data in equine gastrointestinal colic.
The discriminating ability of 15 parameters alone or in combinations, including results from analysis of plasma endotoxin, the Nycomed plasma D-Dimer test and phospholipase A2, were analyzed to predict morbidity and mortality in equine gastrointestinal colic. Endotoxaemia was a characteristic feature of the colic horses. The problem of adequately predicting nonsurvivors among colic horses required several parameters to be included in the logistic model: if the "classical parameters", (heart rate, respiratory rate, PCV, anion gap) were included in the model, addition of plasma D-dimer, phospholipase A2, and Cl- significantly improved the predictive value of the logistic model. Increasing heart rate and D-dimer together with decreasing chloride was a risk factor for nonsurvival. The sensitivity of this three-parameter logistic model to predict nonsurvival was 78% and specificity 77%. The Nycomed D-Dimer test is recommended as a horse-site test to predict disseminated intravascular coagulation and nonsurvival in equine colic.
D000818:Animals; D015415:Biomarkers; D003085:Colic / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000662:veterinary*; D004731:Endotoxins / Q000097:blood; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005767:Gastrointestinal Diseases / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000662:veterinary*; D006339:Heart Rate; D006734:Horse Diseases / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D006736:Horses; D015999:Multivariate Analysis; D010088:Oxidoreductases / Q000097:blood; D010741:Phospholipases A / Q000097:blood; D054467:Phospholipases A2; D011379:Prognosis; D012119:Respiration; D012189:Retrospective Studies
D015415:Biomarkers; D004731:Endotoxins; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D010088:Oxidoreductases; D010741:Phospholipases A; D054467:Phospholipases A2