title: Multidrug resistance plasmid pSK108 from coagulase-negative staphylococci; relationships to Staphylococcus aureus qacC plasmids.
abstract: The 2.4-kb Staphylococcus epidermidis plasmid, pSK108, encodes a qacC multidrug resistance determinant. Sequence analysis has revealed that pSK108 is a member of the pC194 family of rolling circle replicating plasmids and suggests that the DNA segment containing qacC, which is bounded by the replication nick site and the minus origin palA, represents a resistance gene cassette that has undergone horizontal genetic exchange.
mesh_terms: D000595:Amino Acid Sequence; D017920:Antiporters; D001426:Bacterial Proteins / Q000235:genetics; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics; D003030:Coagulase / Q000378:metabolism; D004269:DNA, Bacterial / Q000235:genetics; D018432:Drug Resistance, Multiple / Q000235:genetics*; D029968:Escherichia coli Proteins; D005798:Genes, Bacterial; D008565:Membrane Proteins / Q000235:genetics; D008969:Molecular Sequence Data; D010957:Plasmids / Q000235:genetics*; D013211:Staphylococcus aureus / Q000235:genetics*; D013212:Staphylococcus epidermidis / Q000187:drug effects / Q000201:enzymology / Q000235:genetics*
chemical_list: D017920:Antiporters; D001426:Bacterial Proteins; D002352:Carrier Proteins; D003030:Coagulase; D004269:DNA, Bacterial; D029968:Escherichia coli Proteins; D008565:Membrane Proteins; C075436:EmrE protein, E coli