Pharmacokinetics of oral extended-release dosage forms. I. Release kinetics, concentration, and absorbed fraction.
In this study, we derive pharmacokinetic models for oral extended-release (OER) drug products with defined in vivo release kinetics (IVRK) and a compartmental system. Fitting the model to clinical data, we were able to examine the correlation between released and absorbed fractions. Furthermore, we found that absorbed fractions of OER products can be expressed by absorption rate and release duration only. The expression is unchanged in different compartmental systems with the same IVRK, implying that the IVRK drives the pharmacokinetic system of an OER product. The apparent absorption rate constant of an OER product can be estimated by solving an implicit equation using observed concentrations. We also propose a new method for calculating absorbed fractions, which is more accurate than Loo-Riegelman method. Ultimately, these methods may permit optimally designed OER products.
D000042:Absorption; D000284:Administration, Oral; D001825:Body Fluid Compartments; D003692:Delayed-Action Preparations / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D007700:Kinetics; D008432:Mathematical Computing; D008722:Methods; D008954:Models, Biological
D003692:Delayed-Action Preparations