title: Postprandial changes in platelet function and coagulation factors after high-fat meals with different fatty acid compositions.
abstract: OBJECTIVE
  To compare the postprandial effects of three oils differing in their fatty acid composition on platelet aggregation and coagulation. The oils studied were low-erucic acid rapeseed oil (RO, oleic acid 54% of fatty acids), sunflower oil (SO, linoleic acid 64% of fatty acids) and butter oil (BO, saturated fatty acids 62% of fatty acids).
  
  
  METHODS
  The postprandial effects of three fat-loads were followed for 5 h.
  
  
  METHODS
  Division of Nutrition, University of Helsinki.
  
  
  METHODS
  Twelve healthy female subjects (aged 23-38 years) were recruited among university students and employees.
  
  
  METHODS
  Postprandial lipaemia was induced by high-fat meals containing fat (RO, SO or BO) 1 g/kg of body weight, skim-milk powder, sugar, strawberries, and water. Each subject ingested each meal in three separate mornings after an overnight fast. The order of the meals was randomised. Blood samples were taken before and 1, 2.5, and 5 h after the test meal.
  
  
  RESULTS
  All three test meals similarly affected platelet aggregation in platelet-rich plasma. Aggregation induced by collagen (0.6, 1 and 2.5 micrograms/ml) decreased during the 5-h period after the meals (P = 0.000). ADP-induced aggregation did not change during the follow-up period after any meal (P = 0.105-0.483). All fat loads increased factor VII coagulant activity (F VII:C) (P = 0.000), but in plasma fibrinogen concentration (P = 0.155) or antithrombin III activity (P = 0.278) no postprandial changes were found.
  
  
  CONCLUSIONS
  These results show that high-fat meals have acute effects on platelet function and F VII:C in healthy women and that these effects are not mediated through the fatty acid composition of the meals.
mesh_terms: D000328:Adult; D001777:Blood Coagulation / Q000187:drug effects*; D001792:Blood Platelets / Q000187:drug effects*; D004041:Dietary Fats / Q000494:pharmacology*; D004435:Eating; D005224:Fats, Unsaturated / Q000737:chemistry; D005227:Fatty Acids / Q000032:analysis / Q000494:pharmacology*; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000097:blood / Q000209:etiology; D010938:Plant Oils / Q000737:chemistry / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D004041:Dietary Fats; D005224:Fats, Unsaturated; D005227:Fatty Acids; D010938:Plant Oils