title: Motor units: remodeling in aged animals.
abstract: The effects of aging on motor units of different types and the spatial arrangement of motor units are discussed. This article is, however, not a comprehensive survey of the literature, but rather a summary of our own results with the addition of relevant reports. The glycogen depletion technique was used to identify the muscle fibers in a motor unit (motor unit fibers). The motor unit fibers were subsequently characterized according to immunocytochemical, enzyme-histochemical and morphometrical properties, and the spatial arrangement was determined with the aid of a computer-assisted model. An age-related motor unit transformation was observed in both fast- and slow-twitch rat skeletal muscles as was a rearrangement of motor unit fibers. The spatial redistribution of motor unit fibers, higher innervation ratios, and larger motor unit territories in old age indicate an age-related denervation-reinnervation process due to loss of alpha-motoneurones.
mesh_terms: D000222:Adaptation, Physiological; D000375:Aging / Q000473:pathology / Q000502:physiology*; D000818:Animals; D006003:Glycogen; D006651:Histocytochemistry; D007150:Immunohistochemistry; D008954:Models, Biological; D009046:Motor Neurons / Q000502:physiology / Q000648:ultrastructure; D018656:Muscle Fibers, Fast-Twitch / Q000502:physiology / Q000648:ultrastructure; D018485:Muscle Fibers, Skeletal / Q000502:physiology* / Q000648:ultrastructure; D018657:Muscle Fibers, Slow-Twitch / Q000502:physiology / Q000648:ultrastructure; D018482:Muscle, Skeletal / Q000294:innervation / Q000502:physiology / Q000648:ultrastructure; D051381:Rats
chemical_list: D006003:Glycogen