title: [Study of the mutagenic activity of cadmium by the method of dominant lethal mutation].
abstract: Calculation of dominant lethal mutations was executed in intact female mouse, mated with male on 1 and 6 week after single intragastric ingestion maximum tolerated dose CdCl2 (2 mg of Cd per kg of body mass). The increase of total, pre- and postimplantation lethality was found within first 4 weeks of observation. This effect testifies the alteration of spermatogenesis cycle on late stages when reparation of DNA is absent. On early stages of spermatogenesis (5th and 6th weeks) the dominant lethal mutations were on the same level as in control group.
mesh_terms: D000818:Animals; D002104:Cadmium / Q000633:toxicity*; D004260:DNA Repair; D004622:Embryo, Mammalian / Q000187:drug effects; D005260:Female; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D008954:Models, Biological; D009152:Mutagenicity Tests; D009154:Mutation / Q000235:genetics*; D011247:Pregnancy; D013091:Spermatogenesis / Q000187:drug effects
chemical_list: D002104:Cadmium
vernacular_title: Izuchenie mutagennoĭ aktivnosti kadmiia metodom dominantnykh letal'nykh mutatsiĭ.