[Effect of microinjection of sodium giutamate and glycine into ventrolateral nucleus of tractus solitarius on the evoked potentials of arcuatus nucleus in rabbits].
Experiments were performed on 66 anaesthetized, vagotomized, paralyzed and artificially ventilated rabbits. The effects of microinjection sodium glutamate and glycine into ventrolateral nucleus of tractus solitarius (VLNTS) on hypothalamic arcuatus nucleus evoked potentials were observed. The main results obtained were as follows: (1) Phrenic nerve discharges were increased and the amplitude of P2 and N2 waves of arcuatus nucleus evoked potentials were decreased by microinjection of sodium glutamate into VLNTS. Phrenic nerve discharges were decreased and the amplitude of P2 and N2 waves of arcuatus nucleus evoked potentials were increased by microinjection of glycine into VLNTS. (2) After intravenous injection of naloxone, the phrenic nerve discharges could still be excited by microinjection of sodium glutamate as before, but the effects on the amplitude of P2 and N2 waves of arcuatus nucleus evoked potentials, unlike that of sodium glutamate, were reversed. The results suggest that the excitatory action of respiratory neurons in the VILTS may affect on the sensory function of arcuatus nucleus. The mechanism involved was discussed.
D000818:Animals; D001111:Arcuate Nucleus of Hypothalamus / Q000502:physiology*; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D005998:Glycine / Q000494:pharmacology*; D008297:Male; D008845:Microinjections; D011817:Rabbits; D012970:Sodium Glutamate / Q000494:pharmacology*; D017552:Solitary Nucleus / Q000502:physiology*
D005998:Glycine; D012970:Sodium Glutamate