Chromosomal localization, embryonic expression, and imprinting tests for Bmp7 on distal mouse chromosome 2.
Murine Bmp7 has been assigned to distal Chromosome 2 by interspecific backcross mapping. The map location suggests close linkage to classical mouse mutations and places Bmp7 within a chromosome region thought to contain one or more unidentified imprinted genes. A direct test suggests that Bmp7 is not imprinted. An examination of embryonic RNA expression patterns shows that Bmp7 is expressed in a variety of skeletal and nonskeletal tissues. Both embryonic expression patterns and the human chromosomal sublocalization inferred from its mouse location make Bmp7 a candidate for the gene affected in some patients with Holt-Oram syndrome.
D000818:Animals; D019485:Bone Morphogenetic Proteins; D002874:Chromosome Mapping; D018507:Gene Expression Regulation, Developmental; D018392:Genomic Imprinting; D006801:Humans; D051379:Mice; D009154:Mutation; D011506:Proteins / Q000235:genetics*; D012313:RNA / Q000378:metabolism; D013577:Syndrome
D019485:Bone Morphogenetic Proteins; D011506:Proteins; D012313:RNA