title: Autism and genetics: clinical approach and association study with two markers of HRAS gene.
abstract: Twin studies and familial aggregation studies indicate that genetic factors could play a role in infantile autism. In an earlier study, we identified a possible positive association between autism and a c-Harvey-ras (HRAS) oncogene marker at the 3' end of the coding region. In an attempt to confirm this finding, we studied a larger population, well-characterized clinically and genetically. We report a positive association between autism and two HRAS markers, the 3' marker used in the initial study and an additional marker in exon 1.
mesh_terms: D000293:Adolescent; D001321:Autistic Disorder / Q000235:genetics* / Q000523:psychology; D002648:Child; D002675:Child, Preschool; D005091:Exons; D005260:Female; D011905:Genes, ras; D005819:Genetic Markers; D006801:Humans; D007223:Infant; D008297:Male; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
chemical_list: D005819:Genetic Markers