title: Effects of surgical menopause on psychological characteristics and lipid levels: the Healthy Women Study.
abstract: The authors examined the effects of surgical menopause, with or without hormone replacement therapy (HRT), on psychosocial functioning and lipid levels in a population-based study of initially premenopausal women. Within 5 years of study entry, 28 women underwent hysterectomy, with 9 retaining their ovaries and 19 having bilateral salpingo oophorectomy (BSO), and with 173 premenopausal women as a comparison group. Women undergoing hysterectomy reported fewer stress symptoms and a more optimistic attitude at follow-up, whereas BSO cases without HRT had lower mean total high-density lipoprotein (HDL) and HDL2, relative to premenopausal women. Subject to limited power, the authors' findings suggest that surgical menopause among middle-aged women does not lead to negative psychological outcomes but that BSO in the absence of hormone use has significant adverse effects on the HDL and HDL2.
mesh_terms: D000223:Adaptation, Psychological / Q000187:drug effects*; D000328:Adult; D008076:Cholesterol, HDL / Q000097:blood; D002979:Climacteric / Q000097:blood / Q000187:drug effects / Q000523:psychology*; D015331:Cohort Studies; D003866:Depressive Disorder / Q000097:blood / Q000175:diagnosis / Q000523:psychology; D015914:Estrogen Replacement Therapy; D005187:Fallopian Tubes / Q000601:surgery; D005260:Female; D006801:Humans; D007044:Hysterectomy / Q000523:psychology*; D008055:Lipids / Q000097:blood*; D008594:Menopause, Premature / Q000097:blood / Q000187:drug effects / Q000523:psychology*; D008875:Middle Aged; D010052:Ovariectomy / Q000523:psychology; D010552:Personality Assessment; D011446:Prospective Studies; D012917:Social Adjustment
chemical_list: D008076:Cholesterol, HDL; D008055:Lipids