title: Macrophages and microglia in HSV-1 infected mouse brain.
abstract: We have examined the macrophage and microglial cell response in mouse brains during the course of acute herpes simplex encephalitis produced by intranasal inoculation of virus. Macrophage infiltration and a microglial cell reaction were detected from 24 h after initial detection of HSV-1 antigen in brain. Macrophage infiltration was confined to focal areas of infection but the microglial cell reaction occurred in a more widespread distribution. Following disappearance of viral antigen, with resolution of the acute infection, macrophage infiltration and a focal microglial cell reaction remained for several weeks, providing a marker of sites of previous infection.
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001921:Brain / Q000473:pathology* / Q000821:virology; D018792:Encephalitis, Viral / Q000276:immunology* / Q000473:pathology; D006561:Herpes Simplex / Q000276:immunology* / Q000473:pathology; D018259:Herpesvirus 1, Human / Q000276:immunology; D008264:Macrophages / Q000276:immunology* / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D017628:Microglia / Q000276:immunology* / Q000473:pathology
chemical_list: D000956:Antigens, Viral