Up-regulation of trkB mRNA expression in the rat striatum after seizures.
The present study investigates the expression of a tyrosine kinase receptor (trkB), its specific ligands brain-derived neurotrophic factor (BDNF) and neurotrophin-4 (NT-4) mRNAs in the striatum after seizures. The result showed an increase of trkB mRNA expression, both with and without tyrosine kinase domain, in the caudate-putamen and nucleus accumbens, but not in the globus pallidus. This increase peaked 3 h after treatment, and returned to normal levels by 12 h. The BDNF and NT-4 mRNAs showed no change at any time. In conclusion, the widespread and massive trkB mRNA induction after abnormal neuronal activity suggests local trophic support for this receptor, and a potential role in basal ganglia diseases involving non-dopaminergic components.
D000818:Animals; D019208:Brain-Derived Neurotrophic Factor; D003342:Corpus Striatum / Q000378:metabolism*; D015870:Gene Expression; D008297:Male; D009414:Nerve Growth Factors / Q000096:biosynthesis* / Q000494:pharmacology*; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D010862:Pilocarpine / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics; D012640:Seizures / Q000378:metabolism*; D013997:Time Factors; D015854:Up-Regulation
D019208:Brain-Derived Neurotrophic Factor; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D010862:Pilocarpine; D011505:Protein-Tyrosine Kinases; D020794:Receptor Protein-Tyrosine Kinases; C073922:neurotrophin 4