title: Outcome and quality of life of patients with severe chronic limb ischaemia: a cohort study on the influence of diabetes.
abstract: OBJECTIVE
  To determine the influence of diabetes on the use of arterial reconstruction, the rate of amputation and death, and the quality of life of patients with severe limb ischaemia.
  
  
  METHODS
  A prospective study of patients with the first episode of ischaemia.
  
  
  METHODS
  University tertiary referral centre.
  
  
  METHODS
  Thirty-seven patients with diabetes and 50 without diabetes, were studied over a 12 month period with complete follow-up.
  
  
  METHODS
  The proportion of patients undergoing an arterial reconstruction, amputation rate, death rate, and quality-of-life scores.
  
  
  RESULTS
  Patients with diabetes underwent an arterial reconstruction less often than patients without diabetes (7/37 vs. 18/50). The odds of patients with diabetes having a higher incidence of adverse outcome was 1666:1 for minor amputation, 26:1 for major amputation, and 4.7:1 for death. There was a tendency towards a lower quality of life for patients with diabetes at 3 (OR 1.94, p = 0.036), 6 (OR 1.58, p = 0.117), and 12 (OR 1.47, p = 0.185) months.
  
  
  CONCLUSIONS
  In patients with diabetes, (1) the opportunity of undergoing an arterial reconstruction is lower, (2) morbidity and mortality are higher, and (3) the quality of life tends to be worse.
mesh_terms: D000203:Activities of Daily Living; D000328:Adult; D000368:Aged; D000671:Amputation, Surgical; D001158:Arteries / Q000601:surgery; D002908:Chronic Disease; D015331:Cohort Studies; D048909:Diabetes Complications; D004691:Endarterectomy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007511:Ischemia / Q000150:complications / Q000601:surgery*; D007866:Leg / Q000098:blood supply*; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D011183:Postoperative Complications; D011446:Prospective Studies; D011788:Quality of Life; D016019:Survival Analysis; D015996:Survival Rate; D016896:Treatment Outcome