title: Validation of a modified 28-day rat study to evidence effects of test compounds on the immune system.
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000633:toxicity*; D005260:Female; D006462:Hemolytic Plaque Technique; D006801:Humans; D007107:Immune System / Q000187:drug effects* / Q000473:pathology; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood / Q000187:drug effects; D007075:Immunoglobulin M / Q000096:biosynthesis / Q000097:blood / Q000187:drug effects; D016130:Immunophenotyping; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D007694:Killer Cells, Natural / Q000276:immunology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects; D008221:Lymphoid Tissue / Q000187:drug effects / Q000473:pathology; D008262:Macrophage Activation / Q000187:drug effects; D008297:Male; D008934:Mitogens / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D018675:Toxicity Tests / Q000592:standards*
chemical_list: D007074:Immunoglobulin G; D007075:Immunoglobulin M; D008934:Mitogens; D016572:Cyclosporine