Aerosolized furosemide in wheezy infants: a negative report.
We investigated the effects of 10 mg aerosolized furosemide on clinical score in 28 acutely wheezing infants (Part A) and in a second group of 20 intermittently wheezing babies on airway resistance and functional residual capacity during a symptomfree period (Part B), using a double-blind, placebo-controlled design. In both parts of the study no therapeutic effects were observed during and following aerosol inhalation of 10 mg furosemide.
D000280:Administration, Inhalation; D000336:Aerosols; D000403:Airway Resistance / Q000187:drug effects / Q000502:physiology; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage*; D001988:Bronchiolitis / Q000188:drug therapy* / Q000503:physiopathology; D004311:Double-Blind Method; D005260:Female; D005652:Functional Residual Capacity / Q000187:drug effects / Q000502:physiology; D005665:Furosemide / Q000008:administration & dosage*; D006801:Humans; D007223:Infant; D008297:Male; D012135:Respiratory Sounds / Q000187:drug effects* / Q000503:physiopathology; D017211:Treatment Failure
D000336:Aerosols; D018927:Anti-Asthmatic Agents; D005665:Furosemide