[The lipid peroxidation indices of hypertension patients undergoing combined therapy with anaprilin, korinfar and hypothiazide].
Lipid peroxidation (LPO) products and activity of antioxidant defense (AOD) were evaluated in the whole blood and red cells of 78 patients with hypertension stage II given anapriline, corinfar and hypotiazid. Combined therapy with anapriline and hypotiazid (80-120 mg/day and 50 mg/day, respectively) diminishes concentrations of diene conjugates and malonic dialdehyde (MDA) in blood though LPO parameters after the treatment exceeded those of healthy subjects. Native antioxidants content and activity of antioxidant enzymes glutathione peroxidase and superoxide dismutase increased. Combination of corinfar (30-60 mg/day) with anapriline (80-120 mg/day) inhibits LPO and antioxidant defense activity to optimal leading to normalization of some LPO values and activity of antioxidant enzymes after the treatment. This combination was also effective as related to lowering of high blood pressure.
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D000975:Antioxidants; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use*; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use*; D011433:Propranolol / Q000627:therapeutic use*
D000959:Antihypertensive Agents; D000975:Antioxidants; D006852:Hydrochlorothiazide; D011433:Propranolol; D009543:Nifedipine
Pokazateli lipoperoksidatsii u bol'nykh gipertonicheskoĭ bolezn'iu pri kompleksnoĭ terapii anaprilinom, korinfarom i gipotiazidom.