Gene therapy to restore prostacyclin presence to injured endothelium.
These preliminary studies demonstrate the feasibility of restoration of prostacyclin synthesis in mechanically-injured porcine carotid arteries following angioplasty. Our initial data suggest the possibility of inhibiting thrombus development by adenovirus-CMV-PGHS-1 therapy in the initial 10 days following angioplasty.
D000256:Adenoviridae / Q000235:genetics; D000818:Animals; D002339:Carotid Arteries / Q000378:metabolism; D020212:Carotid Artery Injuries; D003327:Coronary Disease / Q000378:metabolism / Q000628:therapy; D004730:Endothelium, Vascular / Q000293:injuries* / Q000378:metabolism*; D011464:Epoprostenol / Q000378:metabolism*; D015316:Genetic Therapy / Q000379:methods*; D006801:Humans; D011451:Prostaglandin-Endoperoxide Synthases / Q000235:genetics / Q000378:metabolism; D013552:Swine
D011464:Epoprostenol; D011451:Prostaglandin-Endoperoxide Synthases