title: Effect of Guglielmi detachable coils on experimental carotid artery aneurysms in primates.
abstract: OBJECTIVE
  Clinical experience has established that intravascularly placed metal coils can be a useful treatment for cerebral vascular aneurysms. However, the mechanism by which the coils induce occlusion of the aneurysm is unclear. Appropriate use of this promising treatment modality requires basic understanding of the occlusive process. We used an animal model system of experimentally induced carotid aneurysms to investigate the initial events induced by Guglielmi detachable coils (GDCs), as well as the subsequent vascular changes induced by the coils over time.
  
  
  METHODS
  We induced 23 aneurysms in the carotid arteries of 16 Japanese monkeys. Nineteen aneurysms were then occluded with GDCs placed via endovascular surgery; 4 aneurysms served as controls. We then used gross and microscopic pathological examination, angiography, and scanning electron microscopy to assess the effects of the GDC.
  
  
  RESULTS
  In the first few hours after placement of the GDC in the experimental aneurysms, we observed leukocyte attachment and deposition of fibrinlike materials and other proteins. By 4 days after coil placement, leukocytes and fibroblasts were observed in the thrombus. By 2 weeks after coil placement, there was evidence of an endothelial-like covering of the coils. At 3 months after coil placement, we observed development of an arterial media in the occluded aneurysms.
  
  
  CONCLUSIONS
  The GDCs initiated a cellular response within several hours of aneurysm occlusion. By 2 weeks after coil placement, endothelialization was proceeding, and by 3 months after occlusion, remodeling of the aneurysm had progressed to produce a media-like structure in the former aneurysm.
mesh_terms: D000783:Aneurysm / Q000503:physiopathology / Q000628:therapy*; D000818:Animals; D002339:Carotid Arteries / Q000473:pathology* / Q000648:ultrastructure; D002340:Carotid Artery Diseases / Q000503:physiopathology / Q000628:therapy*; D004621:Embolization, Therapeutic / Q000295:instrumentation / Q000379:methods*; D007261:Infusions, Intra-Arterial; D008251:Macaca; D008670:Metals; D008855:Microscopy, Electron, Scanning; D013995:Time
chemical_list: D008670:Metals