title: Characterization of the opioid receptor subtypes mediating the negative inotropic effects of DAMGO, DPDPE and U-50, 488H in isolated human right atria strips.
abstract: The present investigation was aimed at elucidating if mu-, delta- and kappa-opioid receptors are involved in the effects of DAMGO (selective mu-agonist), DPDPE (selective delta-agonist) and U-50,488H (selective kappa-agonist) in isolated electrically driven human right atria strips. The negative inotropic effects induced by the opioid agonists used in this study were not antagonized in presence of naloxone (preferentially mu-antagonist), naltrindole (selective delta-antagonist) and norbinaltorphimine (selective kappa-antagonist). These data suggest that the opioid receptors are not involved in the cardiac depressant effects induced by mu-, delta- and kappa-opioid agonists.
mesh_terms: D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D000328:Adult; D000368:Aged; D000700:Analgesics / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D020881:Enkephalin, D-Penicillamine (2,5)-; D004745:Enkephalins / Q000494:pharmacology*; D005260:Female; D006325:Heart Atria / Q000737:chemistry*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects; D009270:Naloxone / Q000494:pharmacology; D009271:Naltrexone / Q000031:analogs & derivatives / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D009294:Narcotics / Q000819:agonists; D011759:Pyrrolidines / Q000494:pharmacology*; D011957:Receptors, Opioid / Q000032:analysis*
chemical_list: D000700:Analgesics; D004745:Enkephalins; D009292:Narcotic Antagonists; D009294:Narcotics; D011759:Pyrrolidines; D011957:Receptors, Opioid; D020875:Enkephalin, Ala(2)-MePhe(4)-Gly(5)-; D009270:Naloxone; C051844:norbinaltorphimine; D009271:Naltrexone; D019900:3,4-Dichloro-N-methyl-N-(2-(1-pyrrolidinyl)-cyclohexyl)-benzeneacetamide, (trans)-Isomer; D020881:Enkephalin, D-Penicillamine (2,5)-; C055382:naltrindole