Hormonal effects of thoracic extradural analgesia for cardiac surgery.
We have investigated the hormonal and metabolic effects of thoracic extradural analgesia with bupivacaine in addition to sufentanil 20 micrograms kg-1 in nine patients undergoing coronary artery bypass surgery. A control group received general anaesthesia alone. The catecholamine response was inhibited for 24 h after surgery in patients who had received extradural analgesia, and the cortisol response was suppressed during cardiopulmonary bypass. Blood glucose values were unchanged until 24 h after surgery in the extradural group. There were no significant differences in cardiac index between the two groups of patients, although heart rate and mean arterial pressure decreased before surgery in patients who received extradural analgesia. The benefits of this technique in terms of a reduction in postoperative morbidity remain to be determined.
D000328:Adult; D000368:Aged; D015360:Analgesia, Epidural; D000768:Anesthesia, General; D000779:Anesthetics, Local / Q000494:pharmacology*; D002045:Bupivacaine / Q000494:pharmacology*; D001026:Coronary Artery Bypass; D004837:Epinephrine / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006439:Hemodynamics / Q000187:drug effects*; D006728:Hormones / Q000097:blood*; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000097:blood
D000779:Anesthetics, Local; D006728:Hormones; D007328:Insulin; D013006:Growth Hormone; D006854:Hydrocortisone; D009638:Norepinephrine; D002045:Bupivacaine; D004837:Epinephrine