[Comparison of the effectiveness and tolerance of Aktiferrin, a ferrous sulfate capsule preparation and Tardyferon pills in patients with uncomplicated sideropenic anemia].
BACKGROUND
The most frequent complications of oral administration of medicinal iron are gastrointestinal complaints the incidence of which correlates with the iron content of the preparation. The objective of the present work was to compare the effectiveness and tolerance of two ferrous sulphate preparations, Aktiferrin capsules and Tardyferon dragées which differ as to the elemental iron content.


RESULTS
To two groups of patients with sideropenic anaemia selected at random (39 women and 1 men, age 14-61 years, median 28 years) Aktiferrin or Tardyferon was administered. Administration of the preparations which have a more than double different elemental iron content had a comparable effect on the investigated haematological parameters. In the group treated with Akiferrin no GIT intolerance was observed, in the group with Tardyferon it was observed in four patients.


CONCLUSIONS
Aktiferrin has a comparable therapeutic effect although it contains 2.5 times less elemental iron, as compared with Tardyferon.
D000293:Adolescent; D000328:Adult; D018798:Anemia, Iron-Deficiency / Q000188:drug therapy*; D002214:Capsules; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D005260:Female; D005296:Ferrous Compounds / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use
D002214:Capsules; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D005296:Ferrous Compounds; D009077:Mucins; C020748:ferrous sulfate; C009380:ferrous sulfate, mucin drug combination
Porovnanie úcinnosti a tolerancie ferosulfátových prípravkov Aktiferrin kapsle a Tardyferon drazé u pacientov s nekomplikovanou sideropenickou anémiou.