title: Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. I. Acute infection.
abstract: The present study describes the replication of Theiler's virus in cloned cerebrovascular endothelial cells (CVE) isolated from strains of mice that are either susceptible or resistant to Theiler's virus-induced demyelination (TVID). CVE isolated from all strains of mice were equally permissive to Theiler's virus infection. Interferon-gamma and tumor necrosis factor-alpha were found to inhibit the replication of Theiler's virus in CVE. A correlation between susceptibility to demyelination and the ability of Theiler's virus to induce MHC Class I on CVE was demonstrated.
mesh_terms: D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000821:virology; D002999:Clone Cells; D004730:Endothelium, Vascular / Q000276:immunology / Q000821:virology*; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007371:Interferon-gamma / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011051:Poliomyelitis / Q000276:immunology* / Q000821:virology; D013601:T-Lymphocytes / Q000502:physiology; D017945:Theilovirus / Q000187:drug effects / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma