High-density lipoprotein fails to inhibit serotonin-induced activation of blood platelets.
High-density lipoprotein (HDL) of 100-400 micrograms/ml did not prevent morphological alterations of human blood platelets treated with serotonin (1-5 microM). Highly concentrated HDL (1,200 micrograms/ml) appeared to activate platelets in vitro. These findings indicate that whole HDL may not inhibit agonist-induced platelet activation.
D001792:Blood Platelets / Q000187:drug effects / Q000648:ultrastructure; D006801:Humans; D008075:Lipoproteins, HDL / Q000494:pharmacology*; D008854:Microscopy, Electron; D015539:Platelet Activation / Q000187:drug effects*; D012701:Serotonin / Q000494:pharmacology*
D008075:Lipoproteins, HDL; D012701:Serotonin