title: Molecular genetics of the ABO histo-blood group system.
abstract: Molecular genetic study of the histo-blood group ABO system has elucidated the allelic basis of this genetic locus. Comparison of the nucleotide sequence has identified in the coding region differences which change amino acid sequences of the glycosyltransferases coded by these genes. Effects of the differences (mutations) on the specificity and activity of the glycosyltransferases have been examined.
mesh_terms: D000017:ABO Blood-Group System / Q000235:genetics*; D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D002240:Carbohydrate Sequence; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D016695:Glycosyltransferases / Q000235:genetics*; D006801:Humans; D008969:Molecular Sequence Data
chemical_list: D000017:ABO Blood-Group System; D016695:Glycosyltransferases