title: [Ret proto-oncogene mutations associated with type 2 multiple endocrine neoplasms (MEN 2). Clinical implications].
abstract: Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant cancer syndrome. Clinical features and diagnostic aspects of this syndrome are reviewed with a focus on progress biochemical screening to genetic analysis of those at risk. The clinical implications resulting from the application of the new methods of molecular biology are discussed.
mesh_terms: D029721:Drosophila Proteins; D006801:Humans; D018813:Multiple Endocrine Neoplasia Type 2a / Q000235:genetics* / Q000628:therapy; D009154:Mutation; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*
chemical_list: D029721:Drosophila Proteins; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D051096:Proto-Oncogene Proteins c-ret; D020794:Receptor Protein-Tyrosine Kinases; C416649:Ret protein, Drosophila
vernacular_title: Mutações no Ret Proto-oncogene em associação com neoplasias endócrinas múltiplas tipo 2 (MEN 2). Implicações clínicas.