title: Morphological changes in the skin microlymphatics in recently injured paraplegic patients with ilio-femoral venous thrombosis.
abstract: Based on morphological features of the lymphatic microcirculation of the skin from healthy subjects, and from paraplegic patients who had no evidence of ilio-femoral venous thrombosis (thromboembolic disease: TED), the leg terminal lymphatic vessels from skin biopsies of five male paraplegic patients with acute traumatic spinal cord lesions and with documented TED were studied. Paraplegic patients with TED had lymph vessels with a dilated lumen surrounded by a rarefacted perivascular connective tissue characterized by dissociation and disruption of collagen and elastic fibres. The lymphatic wall was generally attenuated and some open junctions and channels delimited by endothelial protrusions were observed. The venous outflow obstruction caused by deep venous thrombosis accompanied by the absence of ambulatory venous pressure in the paretic leg determines skin microlymphatic dilatation, lymph stasis and changes in the interstitial connective tissues. These alterations may be considered to be the morphological aspect of the dystrophic alterations seen in the skin of legs from paraplegic patients with TED. The results are discussed in view of the correct rehabilitative medical treatment necessary, and adequate prophylaxis of TED.
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D005268:Femoral Vein; D006801:Humans; D007084:Iliac Vein; D008208:Lymphatic System / Q000473:pathology*; D008297:Male; D010264:Paraplegia / Q000150:complications* / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D013119:Spinal Cord Injuries / Q000150:complications / Q000473:pathology; D013923:Thromboembolism / Q000150:complications; D013924:Thrombophlebitis / Q000150:complications*