title: Clinical safety of lidocaine in patients with cocaine-associated myocardial infarction.
abstract: OBJECTIVE
  To evaluate the safety of lidocaine in the setting of cocaine-induced myocardial infarction (MI).
  
  
  METHODS
  A retrospective, multicenter study.
  
  
  METHODS
  Twenty-nine university, university-affiliated, or community hospitals during a 6-year period (total of 117 cumulative hospital-years).
  
  
  METHODS
  Patients with cocaine-associated MI who received lidocaine in the emergency department.
  
  
  RESULTS
  Of 29 patients who received lidocaine in the setting of cocaine-associated MI, no patient died; exhibited bradydysrhythmias, ventricular tachycardia, or ventricular fibrillation; or experienced seizures after administration of lidocaine (95% confidence interval, 0% to 11%).
  
  
  CONCLUSIONS
  Despite theoretical concerns that lidocaine may enhance cocaine toxicity, the use of lidocaine in patients with cocaine-associated MI was not associated with significant cardiovascular or central nervous system toxicity.
mesh_terms: D000328:Adult; D003042:Cocaine; D004630:Emergencies; D005260:Female; D006801:Humans; D008012:Lidocaine / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000188:drug therapy*; D012189:Retrospective Studies; D019966:Substance-Related Disorders / Q000150:complications*
chemical_list: D008012:Lidocaine; D003042:Cocaine