Vogt-Koyanagi-Harada syndrome in a 4-year old child.
OBJECTIVE
We studied a case of severe bilateral Vogt-Koyanagi-Harada syndrome in a 4-year-old boy.


METHODS
We evaluated the patient's clinical course.


RESULTS
The patient had severe bilateral, nongranulomatous uveitis and mild uveitic glaucoma. Initial examination and laboratory evaluation failed to provide a diagnosis. The patient subsequently developed areas of vitiligo, alopecia, and poliosis, suggesting the diagnosis of Vogt-Koyanagi-Harada syndrome. This diagnosis was confirmed by the eventual development of bilateral neurosensory retinal detachments. Vision was lost despite aggressive therapy with corticosteroids and chlorambucil.


CONCLUSIONS
Although uncommon, Vogt-Koyanagi-Harada may affect young children, and may be severe.
D000505:Alopecia / Q000209:etiology; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D018906:Antineoplastic Agents, Alkylating / Q000627:therapeutic use; D001766:Blindness / Q000209:etiology; D002675:Child, Preschool; D002699:Chlorambucil / Q000627:therapeutic use; D005901:Glaucoma / Q000150:complications; D006801:Humans; D008297:Male; D011241:Prednisone / Q000627:therapeutic use; D012163:Retinal Detachment / Q000209:etiology; D014605:Uveitis / Q000150:complications; D014607:Uveomeningoencephalitic Syndrome / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D014820:Vitiligo / Q000209:etiology
D000893:Anti-Inflammatory Agents; D018906:Antineoplastic Agents, Alkylating; D002699:Chlorambucil; D011241:Prednisone