Automated method for determining Instron Residual Seal Force of glass vial/rubber closure systems. Part II. 13 mm vials.
Instron Residual Seal Force (IRSF) of 13 mm glass vial/rubber closure systems was determined using an Instron 4501 Materials Testing System and computerized data analysis. A series of three cap anvils varying in shape and dimensions were machined to optimize cap anvil performance. Cap anvils with spherical top surfaces and narrow internal dimensions produced uniform stress-deformation curves from which precise IRSF values were derived.
D004349:Drug Packaging / Q000379:methods*; D005898:Glass; D008422:Materials Testing; D011312:Pressure; D012408:Rubber; D013678:Technology, Pharmaceutical
D012408:Rubber