Characteristics of cloned cerebrovascular endothelial cells following infection with Theiler's virus. I. Acute infection.
The present study describes the replication of Theiler's virus in cloned cerebrovascular endothelial cells (CVE) isolated from strains of mice that are either susceptible or resistant to Theiler's virus-induced demyelination (TVID). CVE isolated from all strains of mice were equally permissive to Theiler's virus infection. Interferon-gamma and tumor necrosis factor-alpha were found to inhibit the replication of Theiler's virus in CVE. A correlation between susceptibility to demyelination and the ability of Theiler's virus to induce MHC Class I on CVE was demonstrated.
D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000098:blood supply* / Q000821:virology; D002999:Clone Cells; D004730:Endothelium, Vascular / Q000276:immunology / Q000821:virology*; D015395:Histocompatibility Antigens Class I / Q000032:analysis; D000949:Histocompatibility Antigens Class II / Q000032:analysis; D007371:Interferon-gamma / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011051:Poliomyelitis / Q000276:immunology* / Q000821:virology; D013601:T-Lymphocytes / Q000502:physiology; D017945:Theilovirus / Q000187:drug effects / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II; D014409:Tumor Necrosis Factor-alpha; D007371:Interferon-gamma