Influence of antidepressant drugs administration on the morphine inhibitory effect in mice vasa deferentia.
The effect of chronic and acute antidepressant drug administration on peripheral opioid mechanisms was investigated. For this purpose, the inhibitory effect of morphine on electrically-induced contractions of mouse vas deferens was measured. Acute antidepressant administration did not induce any change in morphine inhibition. Chronic fluvoxamine and chlorimipramine treatment induced strong and significant hypersensitivity to morphine-inhibition. Chronic desipramine, desmethylclomipramine and nortriptyline treatment induced the opposite effect. These results seem to show differential opioidergic regulation depending on the monoaminergic antidepressant used. The level of this interaction remains to be elucidated.
D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D004347:Drug Interactions; D004558:Electric Stimulation; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D009020:Morphine / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology; D009638:Norepinephrine / Q000378:metabolism; D011957:Receptors, Opioid / Q000187:drug effects / Q000502:physiology; D013569:Synapses / Q000187:drug effects / Q000502:physiology; D014649:Vas Deferens / Q000187:drug effects* / Q000502:physiology
D000928:Antidepressive Agents; D011957:Receptors, Opioid; D009020:Morphine; D009638:Norepinephrine