Erythrocyte antioxidant enzyme activities in children with myelomeningocele.
Erythrocyte free radical scavenging enzyme activities and their cofactor trace elements in plasma were assessed in 26 selected patients with myelomeningocele, both parents from 10 selected families, and 14 healthy adult controls. All index children except one were deficient in erythrocyte glutathione peroxidase (GSH-Px). Nine of 10 parent pairs had at least one parent with deficient GSH-Px activity. Children with myelomeningocele had significantly lower GSH-Px activities than their parents; the group of 10 parent pairs had significantly lower GSH-Px activities than the control group; and glutathione reductase activities were significantly lower in parents and children with myelomeningocele compared with controls. A deficiency in one or more antioxidant enzymes may increase the risk for neural tube defects.
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy; D004912:Erythrocytes / Q000201:enzymology*; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood* / Q000378:metabolism*; D005980:Glutathione Reductase / Q000097:blood* / Q000378:metabolism*; D005982:Glutathione Transferase / Q000097:blood* / Q000378:metabolism*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008429:Maternal Welfare; D008591:Meningomyelocele / Q000097:blood / Q000201:enzymology*; D009436:Neural Tube Defects / Q000209:etiology; D010865:Pilot Projects; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D013482:Superoxide Dismutase / Q000097:blood* / Q000378:metabolism*; D014635:Valproic Acid / Q000009:adverse effects / Q000627:therapeutic use
D014635:Valproic Acid; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; D005980:Glutathione Reductase; D005982:Glutathione Transferase