Liposomal amphotericin B therapy of murine histoplasmosis.
Liposomal amphotericin B (AmBisome) was compared with amphotericin B deoxycholate for the treatment of disseminated murine histoplasmosis. Liposomal amphotericin B was well tolerated and, milligram for milligram, was as potent as amphotericin B deoxycholate.
D000666:Amphotericin B / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000935:Antifungal Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D015169:Colony Count, Microbial; D004337:Drug Carriers; D006660:Histoplasmosis / Q000188:drug therapy* / Q000382:microbiology; D007165:Immunosuppression Therapy; D007668:Kidney / Q000382:microbiology; D008081:Liposomes; D051379:Mice; D008807:Mice, Inbred BALB C; D013154:Spleen / Q000382:microbiology
D000935:Antifungal Agents; D004337:Drug Carriers; D008081:Liposomes; D000666:Amphotericin B