[Redistribution of fluid phases of the brain during an increase in blood osmolarity].
Intravenous injection of polyethylene glycol 400 to rats (1.5 mmole/100 g body weight) increases blood osmolarity, the total water content in the brain hemispheres exhibiting insignificant changes. Cellular dehydration is accompanied by an augmentation of the volume of extracellular fluid in the intact skull cavity. The increased blood content of the brain is pointed to be a 24% increase in the iron level in its tissues. Skull trepanation enhances the dehydrating effect of polyethylene glycol 400 but does not affect the blood content of the brain.
D000818:Animals; D001798:Blood Proteins / Q000032:analysis; D001834:Body Water / Q000032:analysis*; D001923:Brain Chemistry; D005260:Female; D007424:Intracellular Fluid / Q000032:analysis; D007501:Iron / Q000032:analysis; D011092:Polyethylene Glycols / Q000494:pharmacology*; D051381:Rats; D012964:Sodium / Q000032:analysis; D014207:Trephining; D014882:Water-Electrolyte Balance
D001798:Blood Proteins; D011092:Polyethylene Glycols; D012964:Sodium; D007501:Iron
Pereraspredelenie zhidkostnykh faz mozga pri uvelichenii osmoliarnosti krovi.