[Increased cholesterol content in erythrocyte membranes of patients with chronic renal failure treated with hemodialysis].
The investigate whether the blood rheological disturbances occurring in hemodialyzed patients are related to the erythrocyte lipid composition, cholesterol and phospholipid content was studied of the erythrocyte membrane. The study included 40 patients with chronic renal insufficiency. 34 of them had hypertension and proteinuria. The cholesterol/phospholipid ratio was significantly higher in the patients after hemodialysis (mean 2.48; SD 0.14) compared with the patients before hemodialysis (mean 2.08; SD 0.19). There was a significant increase of cholesterol in subgroup with hypertension and proteinuria. A significant correlation was found between membrane cholesterol/phospholipid ratio and serum levels of LDL-cholesterol.
D000328:Adult; D002462:Cell Membrane / Q000737:chemistry; D002784:Cholesterol / Q000097:blood*; D004912:Erythrocytes / Q000737:chemistry*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000628:therapy; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000209:etiology; D006435:Renal Dialysis / Q000009:adverse effects*; D012212:Rheology
D002784:Cholesterol
Wzrost ilości cholesterolu w błonach erytrocytów u chorych z przewlekła niewydolnościa nerek leczonych hemodializami.