Evidence for the neuronal origin of brain capillary acetylcholinesterase activity.
Acute administration of monosodium-L-glutamate (MSG) to rats induces the degeneration of acetylcholinesterase (AChE)-positive neurons of the area postrema (AP). Chronic treatment with MSG results in the disappearance of AChE activity of area subpostrema (ASP) capillaries. It is concluded that processes of AChE-positive AP neurons terminate within the ASP and may contribute to the AChE activity of ASP capillaries.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000648:ultrastructure; D002196:Capillaries / Q000201:enzymology*; D002560:Cerebrovascular Circulation / Q000187:drug effects; D006651:Histocytochemistry; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects / Q000201:enzymology*; D051381:Rats; D012970:Sodium Glutamate / Q000494:pharmacology
D000110:Acetylcholinesterase; D012970:Sodium Glutamate