The effect of interleukin-1 beta on the efferent activity of the vagus nerve to the thymus.
The effects of intravenous (i.v.) administration of recombinant human interleukin-1 beta (rhIL-1 beta) and human interleukin-1 beta-fraction (hfrIL-1 beta) on the activity of vagal efferent fibers innervating the thymus were observed in urethane-anesthetized rats. An i.v. injection of 10 ng rhIL-1 beta or hfrIL-1 beta caused a similar degree of increase in the efferent activity, which lasted longer than 2 h. The least effective dose was 1 ng and dose-dependent responses were observed after i.v. injection of rhIL-1 beta at doses of 1 ng, 10 ng and 100 ng. The IL-1 beta-induced activation of efferent activity of the vagal branch to the thymus implicates their involvement in the neural modulation of the thymic function.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D005730:Ganglionic Blockers / Q000494:pharmacology; D018738:Hexamethonium / Q000494:pharmacology; D007375:Interleukin-1 / Q000494:pharmacology*; D008297:Male; D009434:Neural Pathways / Q000166:cytology / Q000187:drug effects; D009476:Neurons, Efferent / Q000187:drug effects*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology; D013950:Thymus Gland / Q000294:innervation / Q000502:physiology*; D014628:Vagotomy; D014630:Vagus Nerve / Q000166:cytology / Q000187:drug effects / Q000502:physiology*
D005730:Ganglionic Blockers; D007375:Interleukin-1; D011994:Recombinant Proteins; D013566:Sympathomimetics; D018738:Hexamethonium; D009638:Norepinephrine