Usefulness of cytogenetic analysis in the diagnosis of undifferentiated synovial sarcoma of the chest wall. A case report.
A case of poorly differentiated spindle cell malignant neoplasm of the chest wall in a 21-year-old man is reported. The results of histopathological and immunohistochemical examinations were not characteristic enough to establish the precise diagnosis. Due to the age of the patient and the location of the lesion and NSE positivity of tumor cells, the possibility of Askin's tumour or malignant peripheral nerve sheath tumour was considered. Cytogenetic analysis revealed a chromosomal translocation t(X;18)(p11;q11), which is known as the specific aberration in synovial sarcoma. Chromosome study seems to be a useful tool for identifying undifferentiated mesenchymal tumours.
D000328:Adult; D001706:Biopsy; D006801:Humans; D007621:Karyotyping; D008297:Male; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D013584:Sarcoma, Synovial / Q000175:diagnosis* / Q000235:genetics; D013899:Thoracic Neoplasms / Q000175:diagnosis* / Q000235:genetics; D014057:Tomography, X-Ray Computed; D014178:Translocation, Genetic; D014746:Vimentin / Q000032:analysis
D014746:Vimentin; D010751:Phosphopyruvate Hydratase