[Comparative study of the nucleotide sequence of the gene for the P/C wild strain or L-16 vaccine strain of measles virus].
Nucleotide sequences of P/C gene of measles virus IL wild strain and L-16 vaccine strain were compared with the previously reported nucleotide sequence of Edmonston vaccine strain P/C gene. The primary structure of IL strain P/C gene was characterized by two substitutes in 395 (U-C) and 722 (G-A) positions in comparison with the primary structure of a similar Edmonston strain. Nucleotide sequence of L-16 vaccine strain P/C gene differed from the similar sequence of Edmonston vaccine strain by 3 substitutes in 90 (A-G), 399 (U-C), and 448 (U-C) positions. Comparative analysis of nucleotide substitutes in the P/C gene of L-16, IL, and Edmonston strains indicates that the mutations revealed in the L-16 strain P/C gene are not caused by the strain attenuation, but merely reflect the difference between the strains.
D000818:Animals; D001483:Base Sequence; D002522:Chlorocebus aethiops; D003001:Cloning, Molecular; D018076:DNA, Complementary; D005814:Genes, Viral; D008459:Measles virus / Q000235:genetics*; D008969:Molecular Sequence Data; D014709:Vero Cells; D014765:Viral Vaccines / Q000235:genetics
D018076:DNA, Complementary; D014765:Viral Vaccines
Sravnitel'noe izuchenie nukleotidnoĭ posledovatel'nosti gena P/C dikogo shtamma ili vaktsinnogo shtamma L-16 virusa kori.