Age-related decrease of serotonergic fibres and S-100 beta immunoreactivity in the rat dentate gyrus.
The age-related changes of serotonergic fibres and S-100 beta-positive astrocytes in the rat dentate gyrus were examined using immunohistochemistry. A significant reduction in the number of the serotonergic fibres and S-100 beta-positive astrocytes was observed throughout the dentate gyrus of the aged rat. A positive correlation was noted between the decrease of serotonergic fibres and S-100 beta-positive astrocytes in the aged rat dentate gyrus. These findings support the hypothesis that the age-related degeneration of serotonergic fibres in the dentate gyrus is caused by the decrease in serotonergic neurotrophic factor S-100 beta in the astrocytes.
D000375:Aging / Q000502:physiology*; D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D018891:Dentate Gyrus / Q000166:cytology* / Q000378:metabolism*; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D007150:Immunohistochemistry; D009410:Nerve Degeneration / Q000502:physiology; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D009418:S100 Proteins / Q000378:metabolism*; D012701:Serotonin / Q000502:physiology*
D005904:Glial Fibrillary Acidic Protein; D009418:S100 Proteins; D012701:Serotonin