Central hypothyroidism resulting from pituitary suppression and peripheral thyrotoxicosis in a premature infant born to a mother with Graves disease.
We observed the sequential changes in serum thyroid hormones and thyroid-stimulating hormone receptor antibodies in an infant born at 30 weeks of gestation to a mother with florid Graves disease. Transient central hypothyroidism caused by pituitary suppression was observed after the resolution of peripheral thyrotoxicosis induced by thyroid-stimulating antibody. Central hypothyroidism became overt when the suppression of the pituitary gland after fetal thyrotoxicosis was combined with weak activity of thyroid-stimulating antibody after birth.
D000328:Adult; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000150:complications*; D006333:Heart Failure / Q000097:blood / Q000209:etiology; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000209:etiology*; D018828:Immunoglobulins, Thyroid-Stimulating / Q000097:blood; D007231:Infant, Newborn; D007234:Infant, Premature; D010900:Pituitary Diseases / Q000097:blood / Q000150:complications*; D013963:Thyroid Hormones / Q000097:blood; D013971:Thyrotoxicosis / Q000097:blood / Q000150:complications*
D018828:Immunoglobulins, Thyroid-Stimulating; D013963:Thyroid Hormones