Comparison of the composition and opsonic activities of imported and South African-manufactured intravenous and intramuscular immunoglobulin preparations.
We compared the composition and opsonic activities for two common microbial pathogens (Staphylococcus aureus and Streptococcus pyogenes) of various imported intravenous (IV) (Sandoglobulin, Octagam and Gammagard) and intramuscular (IM) (Beriglobin and Globuman Berna) immunoglobulin (Ig) preparations with those of the corresponding locally manufactured products, Polygam (IV) and Intragam (IM). When tested at equivalent concentrations (1 g/100 ml) the total IgG and IgG subclass concentrations of the various IV and IM preparations were similar. All the test preparations (IV and IM) possessed similar opsonic activity for S. aureus and S. pyogenes. These findings demonstrate that, in respect of IgG content and protective biological activity, Intragam and Polygam, the locally manufactured IM and IV Ig preparations, respectively, compared extremely favourably with the corresponding imported products.
D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000008:administration & dosage / Q000737:chemistry* / Q000276:immunology*; D007262:Infusions, Intravenous / Q000592:standards; D007273:Injections, Intramuscular / Q000592:standards; D009895:Opsonin Proteins / Q000276:immunology*
D016756:Immunoglobulins, Intravenous; D009895:Opsonin Proteins