Acute repeated nicotine injections increase enkephalin and decrease AP-1 DNA binding activity in rat adrenal medulla.
Previously we reported that a single injection of nicotine decreased AP-1 DNA binding activity in adrenal medullae, although chronic bidaily nicotine (and saline) injections increased this binding activity [15]. Repeated acute nicotine injections (3 mg/kg i.p., 7 injections equi-spaced over a 3 h period) effectively increased adrenal tyrosine hydroxylase [3] and [Met5]enkephalin levels and also profoundly decreased adrenal medulla AP-1 DNA binding activity for over 8 h.
D000313:Adrenal Medulla / Q000187:drug effects* / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D004268:DNA-Binding Proteins / Q000378:metabolism*; D004334:Drug Administration Schedule; D004745:Enkephalins / Q000378:metabolism*; D005260:Female; D008297:Male; D008969:Molecular Sequence Data; D009538:Nicotine / Q000008:administration & dosage*; D051381:Rats; D011916:Rats, Inbred F344; D018808:Transcription Factor AP-1 / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000187:drug effects / Q000378:metabolism
D004268:DNA-Binding Proteins; D004745:Enkephalins; D018808:Transcription Factor AP-1; D009538:Nicotine; D014446:Tyrosine 3-Monooxygenase