title: Sense in antisense?
abstract: A correspondence between open reading frames in sense and antisense strands is expected from the hypothesis that the prototypic triplet code was of general form RNY, where R is a purine base, N is any base, and Y is a pyrimidine. A deficit of stop codons in the antisense strand (and thus long open reading frames) is predicted for organisms with high G + C percentages; however, two bacteria (Azotobacter vinelandii, Rhodobacter capsulatum) have larger average antisense strand open reading frames than predicted from (G + C)%. The similar codon frequencies found in sense and antisense strands can be attributed to the wide distribution of inverted repeats (stem-loop potential) in natural DNA sequences.
mesh_terms: D000926:Anticodon; D016375:Antisense Elements (Genetics); D001395:Azotobacter / Q000235:genetics; D001482:Base Composition; D001483:Base Sequence; D003062:Codon; D019143:Evolution, Molecular; D005815:Genetic Code; D008957:Models, Genetic; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D016364:Reading Frames; D012091:Repetitive Sequences, Nucleic Acid; D016992:Rhodobacter / Q000235:genetics
chemical_list: D000926:Anticodon; D016375:Antisense Elements (Genetics); D003062:Codon