title: The assessment of LH surge for predicting ovulation time using clinical, hormonal, and ultrasonic indices in infertile women with an ensemble of neural networks.
abstract: An ensemble of independently trained neural networks (NN) is proposed for the assessment of luteinizing hormone (LH) surge for predicting ovulation time in infertile but ovulating women. The proposed ensemble involves a number of parallel NN modules. Each pair of the NNs learn specific data that are previously collected for monitoring timing function of LH estradiol (pg ml-1), and follicle diameter (mm) are used to train NN pairs to approximate the function of the LH values. A reasonable and accurate estimation places ovulation approximately 10-12 h after the LH peak. The double-valued (bi-phasic) regions of training data are separated into two single-valued (bi-phasic) regions of training data are separated into two single-valued parts (not exactly preovulatory, postovulatory division) that can be learned by each module of the NN pair. During testing, after the initial decision to have single-valued sides, the assessment is obtained by a linear opinion pool (consensus rule) using the decisions of NNs on the corresponding side without waiting. The network ensemble has various desirable properties: high assessment accuracy of a double-valued multisource data, minimized learning and recall times, and a parallel structure. The ovulation time can be predicted through the assessment of LH peak with a better precision and fewer number of tests.
mesh_terms: D003936:Diagnosis, Computer-Assisted / Q000379:methods*; D004958:Estradiol / Q000097:blood; D005260:Female; D006801:Humans; D007247:Infertility, Female / Q000097:blood / Q000175:diagnosis*; D007986:Luteinizing Hormone / Q000097:blood*; D016571:Neural Networks, Computer; D006080:Ovarian Follicle / Q000000981:diagnostic imaging; D010061:Ovulation Detection / Q000379:methods*; D011237:Predictive Value of Tests; D011374:Progesterone / Q000097:blood; D015203:Reproducibility of Results; D014463:Ultrasonography
chemical_list: D011374:Progesterone; D004958:Estradiol; D007986:Luteinizing Hormone