[The immunological reactions and enzymatic activity of the cerebrospinal fluid in intracranial complications following neurosurgical operations].
The specific features of immunological responses and enzymatic activity of cerebrospinal fluid in the development of intracranial infectious complications were outlined in 16 neurosurgical patients after surgical interventions. On days 1-3-5 days after surgery, the immunobiochemical spectrum of cerebrospinal fluid showed substantial changes associated with the impaired permeability of the blood-brain barrier and the stress-induced transition of biochemical functional systems on the minimum functioning during anaerobic energy supply. Increasing lipid peroxidation processes reflect the result of catabolic reactions and energy deficiency, followed by intensive cytolysis of leukocytes and nerve cells. With this, antibody synthesis and great rises in the formation of circulating immune complexes is the essence of sanogenetic mechanisms basically aimed at eliminating the released and bound antigen in the given time interval.
D000917:Antibody Formation; D000936:Antigen-Antibody Complex / Q000134:cerebrospinal fluid; D002555:Cerebrospinal Fluid / Q000201:enzymology / Q000276:immunology; D004796:Clinical Enzyme Tests; D006801:Humans; D015227:Lipid Peroxidation; D008581:Meningitis / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D008590:Meningoencephalitis / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D011183:Postoperative Complications / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D013997:Time Factors
D000936:Antigen-Antibody Complex
Immunologicheskie reaktsii i énzimaticheskaia aktivnost' tserebrospinal'noĭ zhidkosti pri vnutricherepnykh oslozhneniĭ posle neĭrokhirurgicheskikh operatsiĭ.