Early involvement of central nervous system in type I diabetic patients.
OBJECTIVE
To investigate whether the asymptomatic involvement of the central and peripheral nervous systems may be an early complication of diabetes.


METHODS
We studied early impairment of the central and peripheral nervous system pathways in 15 type I diabetic patients with good metabolic control and short disease duration and in 10 healthy control subjects using a set of neurophysiological tests.


RESULTS
Results in diabetic subjects showed 1) impairment of motor (7% and somatosensory (13%) pathways of the central nervous system, 2) impairment of motor and sensory conduction velocities (40-60%), and 3) normal values of the vibration perception threshold and cardiovascular autonomic tests.


CONCLUSIONS
The damage is more evident in peripheral sites where hyperglycemia and aldose reductase pathways are more active. Instead, several episodes of hypoglycemia, which occur in type I diabetic patients in good metabolic control, may cause alterations of brain nervous cells.
D000328:Adult; D002490:Central Nervous System / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D006801:Humans; D009431:Neural Conduction / Q000502:physiology; D010812:Physical Stimulation; D011597:Psychomotor Performance