[Cerebellin in the cerebellum in spinocerebellar degeneration].
To clarify the possible pathophysiological role of cerebellin in spinocerebellar degeneration, immunoreactive cerebellin was measured in the postmortem brain of 4 patients with spinocerebellar degeneration and 4 controls. Three other representative neuropeptides, corticotropin releasing hormone (CRH), neuropeptide Y and somatostatin, were also measured. Significant decreases in the concentration of immunoreactive cerebellin and immunoreactive CRH were found in the cerebellar hemisphere in spinocerebellar degeneration, suggesting an important pathophysiological role of cerebellin and CRH in this group of diseases. No such decreases were found in neuropeptide Y or somatostatin.
D000328:Adult; D000368:Aged; D002531:Cerebellum / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D003346:Corticotropin-Releasing Hormone / Q000032:analysis; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis*; D009478:Neuropeptide Y / Q000032:analysis; D011863:Radioimmunoassay; D013004:Somatostatin / Q000032:analysis; D013132:Spinocerebellar Degenerations / Q000378:metabolism*
D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D013004:Somatostatin; D003346:Corticotropin-Releasing Hormone; C046788:cerebellin