title: [Intestinal pseudo-obstruction during use of baclofen].
abstract: In a 75-year-old man acute intestinal pseudo-obstruction was observed during treatment with baclofen 20 mg daily. After discontinuation of the baclofen he recovered completely. No other cause of intestinal obstruction could be demonstrated. Baclofen is an agonist of spinal GABA receptors. It is used in the treatment of spasticity caused by multiple sclerosis or other diseases of the spinal cord, in particular traumatic lesions. Physicians should be aware of this possible adverse effect of baclofen.
mesh_terms: D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001418:Baclofen / Q000009:adverse effects*; D001726:Bisacodyl / Q000627:therapeutic use; D002400:Cathartics / Q000627:therapeutic use; D020117:Cisapride; D006801:Humans; D007418:Intestinal Pseudo-Obstruction / Q000139:chemically induced* / Q000000981:diagnostic imaging / Q000188:drug therapy; D008297:Male; D009125:Muscle Relaxants, Central / Q000009:adverse effects*; D010880:Piperidines / Q000627:therapeutic use; D011859:Radiography
chemical_list: D000897:Anti-Ulcer Agents; D002400:Cathartics; D009125:Muscle Relaxants, Central; D010880:Piperidines; D001726:Bisacodyl; D001418:Baclofen; D020117:Cisapride
vernacular_title: Intestinale pseudo-obstructie tijdens gebruik van baclofen.