[Synthesis and some biochemical properties of phosphonyl acyclic analogs of 2'-deoxyadenosine nucleotides].
9-[2-(phosphonomethylcarbonylamino)ethyl]adenine, 9-[(2-phosphonoethyl)aminocarbonylmethyl]adenine, 9-[2-[(2-phosphonoethyl)carbonylamino]ethyl]adenine, and their diphosphates were synthesized. All three diphosphates were shown to incorporate into the 3'-terminus of the DNA chain during the synthesis of the avian myeloblastosis virus catalyzed by reverse transcriptase. However, they do not serve as substrates for DNA polymerase alpha from human placenta, polymerase beta from calf thymus, or terminal deoxynucleotidyl transferase from calf thymus.
D000225:Adenine / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000378:metabolism; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D004253:DNA Nucleotidylexotransferase / Q000378:metabolism; D004256:DNA Polymerase I / Q000378:metabolism; D004257:DNA Polymerase II / Q000378:metabolism; D017931:DNA Primers; D006801:Humans; D008969:Molecular Sequence Data; D009943:Organophosphorus Compounds / Q000737:chemistry*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D013379:Substrate Specificity
D017931:DNA Primers; D009943:Organophosphorus Compounds; D004253:DNA Nucleotidylexotransferase; D012194:RNA-Directed DNA Polymerase; D004256:DNA Polymerase I; D004257:DNA Polymerase II; D000225:Adenine
Sintez i nekotorye biokhimicheskie svoĭstva fosfonil'nykh atsiklicheskikh analogov 2'-dezoksiadenozinovykh nukleotidov.