Anti-diabetic effects of onion and garlic sulfoxide amino acids in rats.
On oral administration of onion (Allium cepa L.) and garlic (A. sativum L.) sulfoxide amino acids viz., S-methylcysteine sulfoxide (SMCS) and S-allylcysteine sulfoxide (SACS) to alloxan-diabetic rats for a month, their diabetic condition, being characterized by glucose intolerance, weight loss, depletion of liver glycogen, etc., was ameliorated as comparable to rats treated with glibenclamide and insulin. However, only the last two drugs significantly increased the conversion of labelled acetate to liver cholesterol which indicates a deterrent effect of the allium products against the synthesis of a risk factor.
D000490:Allium; D000818:Animals; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism; D003545:Cysteine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D005737:Garlic; D005905:Glyburide / Q000627:therapeutic use; D007004:Hypoglycemic Agents / Q000627:therapeutic use*; D007328:Insulin / Q000627:therapeutic use; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley
D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007328:Insulin; D008112:Liver Glycogen; C008389:methiin; C006453:alliin; D003545:Cysteine; D005905:Glyburide