Screening and identification of sumatriptan and its main metabolite by means of thin-layer chromatography, ultraviolet spectroscopy and gas chromatography/mass spectrometry.
Sumatriptan (CAS 103628-46-2, 3-[2-(dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulphonamide++ +), a substance for treatment of acute migraine attacks, and its main metabolite are investigated by thinlayer chromatography (TLC), ultraviolet spectroscopy, and gas chromatography/mass spectrometry (GC/MS). The resulting analytical data (correlated hRf-values, UV solvent spectra, remission spectra, GC retention indices, and electron impact (EI) mass spectra) including an extraction procedure and different derivatization methods are presented. Their applicability is described for urine analysis.
D001711:Biotransformation; D002855:Chromatography, Thin Layer; D003720:Densitometry; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D013056:Spectrophotometry, Ultraviolet; D018170:Sumatriptan / Q000032:analysis* / Q000652:urine
D018170:Sumatriptan