title: [Study of the structure-function organization of the variola virus genome. IV. Sequencing and analysis of the nucleotide sequence of the right terminus of the India-1967 strain genome].
abstract: Sequencing and computer analysis of the variola major virus strain India-1967 (VAR-IND) genome segment (53,018 bp) from the right terminal region have been carried out. Fifty nine potential open reading frames (ORFs) of over 60 amino acid residues have been identified. Structure-function organization of VAR-IND DNA segment under study was compared with the previously reported sequences from the analogous genomic regions of vaccinia virus strains Copenhagen (VAC-COP) and Western Reserve (VAC-WR) and variola virus strain Harvey (VAR-HAR). Multiple distinctions in the genetic map of VAR-IND from VAC-COP and VAC-WR have been revealed along with the high similarity to the corresponding VAR-HAR segment. Possible functions of the predicted viral proteins and the effect of their differences on the features of orthopoxviruses are discussed.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D011088:DNA Ligases / Q000235:genetics; D004279:DNA, Viral; D016679:Genome, Viral; D008969:Molecular Sequence Data; D016366:Open Reading Frames; D010957:Plasmids; D018121:Receptors, Cytokine / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013937:Thymidine Kinase / Q000235:genetics; D012901:Variola virus / Q000235:genetics*
chemical_list: D004279:DNA, Viral; D018121:Receptors, Cytokine; D013937:Thymidine Kinase; D011088:DNA Ligases
vernacular_title: Izuchenie strukturno-funktsional'noĭ organizatsii genoma virusa natural'noĭ ospy. IV. Sekvenirovanie i analiz posledovatel'nosti nukleotidov pravogo kontsa genoma shtamma Indiia-1967.