Haemostatic variables in arterial hypertension.
In 22 untreated patients with uncomplicated essential hypertension and in 10 normotensive subjects the plasma levels of thrombomodulin (TM), beta-thromboglobulin (beta-TG), D-dimer (DD), tissue-type plasminogen activator (t-PA) and plasminogen activator-inhibitor (PAI-1) were evaluated. The observed values show no significant difference in plasma TM, plasma and urine beta-TG concentration and plasma DD among hypertensive patients and controls. On the other hand, the levels of t-PA and PAI-1 in hypertensive patients were significantly higher than the values detected in normotensive control subjects. These data seem to indicate that, at initial stages of essential hypertension, the t-PA and PAI-1 levels increase.
D000328:Adult; D001798:Blood Proteins / Q000032:analysis*; D002318:Cardiovascular Diseases / Q000453:epidemiology; D004198:Disease Susceptibility; D005260:Female; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005342:Fibrinolysis; D006801:Humans; D006973:Hypertension / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis; D010979:Platelet Function Tests; D012307:Risk Factors; D018180:Thrombomodulin / Q000032:analysis; D010959:Tissue Plasminogen Activator / Q000032:analysis; D001620:beta-Thromboglobulin / Q000032:analysis
D001798:Blood Proteins; D005338:Fibrin Fibrinogen Degradation Products; D017395:Plasminogen Activator Inhibitor 1; D018180:Thrombomodulin; D001620:beta-Thromboglobulin; C036309:fibrin fragment D; D010959:Tissue Plasminogen Activator