The interaction of trazodone with rat brain muscarinic cholinoceptors.
The muscarinic receptor binding of trazodone, a new nontricyclic antidepressant, was compared with established tricyclic antidepressants. The ability to inhibit the binding of [3H]-quinuclidinyl benzilate in vitro was used for comparing atropine-like effects. Trazodone was found to have essentially no activity at the muscarinic acetylcholine binding site in comparison to the tricyclic antidepressants.
D000818:Animals; D001667:Binding, Competitive; D001921:Brain / Q000378:metabolism*; D066298:In Vitro Techniques; D008297:Male; D010879:Piperazines / Q000378:metabolism*; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D011950:Receptors, Cholinergic / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*; D014196:Trazodone / Q000378:metabolism*
D010879:Piperazines; D011950:Receptors, Cholinergic; D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate; D014196:Trazodone