title: Unbound total (plasma) clearance approach in interspecies pharmacokinetics correlation: theophylline-cimetidine interaction.
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D001835:Body Weight / Q000502:physiology; D002927:Cimetidine / Q000097:blood / Q000493:pharmacokinetics*; D004285:Dogs; D004347:Drug Interactions; D006801:Humans; D008657:Metabolic Clearance Rate; D011485:Protein Binding; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013806:Theophylline / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D001798:Blood Proteins; D002927:Cimetidine; D013806:Theophylline