Gamma interferon is critical for resistance to Theiler's virus-induced demyelination.
Administration of neutralizing monoclonal antibody to gamma interferon increased Theiler's virus-induced demyelination and virus antigen persistence in the spinal cord in susceptible SJL/J mice and completely abrogated resistance such that all C57BL/10SNJ mice developed demyelination. These experiments support the hypothesis that gamma interferon is critically important for resistance to Theiler's virus-induced disease but is not required for myelin destruction.
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology*; D000914:Antibodies, Viral / Q000096:biosynthesis; D000956:Antigens, Viral / Q000032:analysis / Q000096:biosynthesis; D004198:Disease Susceptibility; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D007113:Immunity, Innate; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D007249:Inflammation; D007371:Interferon-gamma / Q000276:immunology / Q000502:physiology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008815:Mice, Inbred Strains; D009186:Myelin Sheath / Q000473:pathology / Q000821:virology; D011051:Poliomyelitis / Q000276:immunology / Q000473:pathology; D013045:Species Specificity; D013116:Spinal Cord / Q000473:pathology* / Q000821:virology; D017945:Theilovirus / Q000276:immunology / Q000302:isolation & purification / Q000472:pathogenicity*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007371:Interferon-gamma