Comparative toxicity of detorubicin and doxorubicin, free and DNA-bound, for hemopoietic stem cells.
We compared the toxicity of detorubicin (DET) and of doxorubicin (DOX) on the hematopoietic stem cells in C57BL6J mice by means of the CFUS and CFUC assays. On an equimolar basis DET appears to be less toxic than DOX for both the pluripotent stem cells and the granulocytic progenitor cells. Moreover, the administration of these anthracyclines as DNA complexes leads to a decreased toxicity to the pluripotent stem cells, while no such attenuated toxic effect is observed in committed stem cells.
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D003114:Colony-Forming Units Assay; D004247:DNA / Q000378:metabolism; D003630:Daunorubicin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000009:adverse effects* / Q000378:metabolism; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D051379:Mice; D008810:Mice, Inbred C57BL
D004317:Doxorubicin; C017218:detorubicin; D004247:DNA; D003630:Daunorubicin