[Antibodies to skeletal muscle myofibrillar proteins in the diagnosis of rheumatoid arthritis].
One of the mechanisms of muscular involvement in RA patients was elucidated by identification of antibodies to skeletal muscle components (actin and tropomyosin). Clinical symptoms of skeletal muscles involvement in RA proved to be associated with elevated count of tropomyosin antibodies against an insignificant informative value of actin. Enzyme immunoassay with tropomyosin has established a direct correlation between the number of the antibodies and RA activity.
D000199:Actins / Q000276:immunology; D000906:Antibodies / Q000097:blood*; D000936:Antigen-Antibody Complex / Q000097:blood; D001172:Arthritis, Rheumatoid / Q000175:diagnosis*; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007841:Latex Fixation Tests; D009124:Muscle Proteins / Q000276:immunology*; D018482:Muscle, Skeletal / Q000276:immunology*; D009210:Myofibrils / Q000276:immunology*; D010003:Osteoarthritis / Q000175:diagnosis; D014335:Tropomyosin / Q000276:immunology
D000199:Actins; D000906:Antibodies; D000936:Antigen-Antibody Complex; D009124:Muscle Proteins; D014335:Tropomyosin
Antitela k miofibrilliarnym belkam skeletnoĭ myshtsy v diagnostike revmatoidnogo artrita.