title: Spasmolytic flavonols from Artemisia abrotanum.
abstract: Four flavonols with spasmolytic activity have been isolated from a methanol extract of Artemisia abrotanum L. (Asteraceae), as the principles primarily responsible for the smooth muscle relaxing activity of this plant. The flavonols show a dose-dependent relaxing effect on the carbacholine-induced contraction of guinea-pig trachea, the EC50 values for compounds 1-3 are 20-30 mumol/l while compound 4 is less active.
mesh_terms: D000700:Analgesics / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D044948:Flavonols; D006168:Guinea Pigs; D066298:In Vitro Techniques; D009126:Muscle Relaxation / Q000187:drug effects*; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D010276:Parasympatholytics / Q000302:isolation & purification / Q000494:pharmacology*; D010936:Plant Extracts; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship; D014132:Trachea / Q000187:drug effects / Q000502:physiology
chemical_list: D000700:Analgesics; D005419:Flavonoids; D044948:Flavonols; D010276:Parasympatholytics; D010936:Plant Extracts