[Cholestasis in imipenem/cilastatin treatment].
The case report on a 22-year-old female patient shows how the treatment with Imipenan/Cilastatin resulted in a severe intrahepatic cholestasis. The serum-bilirubin rapidly decreased after discontinuation of the antibiotic. The laboratory findings were no longer conspicuous four weeks after discharge from hospital.
D000328:Adult; D056486:Chemical and Drug Induced Liver Injury / Q000175:diagnosis / Q000209:etiology* / Q000473:pathology; D002764:Cholecystitis / Q000188:drug therapy*; D002780:Cholestasis, Intrahepatic / Q000139:chemically induced* / Q000175:diagnosis / Q000473:pathology; D015377:Cilastatin / Q000008:administration & dosage / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D015378:Imipenem / Q000008:administration & dosage / Q000009:adverse effects*; D010535:Laparoscopy; D008099:Liver / Q000473:pathology
D015377:Cilastatin; D015378:Imipenem
Cholestase unter Imipenem/Cilastatin-Behandlung.