A homeobox gene essential for zebrafish notochord development.
The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002454:Cell Differentiation / Q000235:genetics; D002874:Chromosome Mapping; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000235:genetics; D005775:Gastrula / Q000166:cytology; D005801:Genes, Homeobox; D005804:Genes, Lethal; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins / Q000235:genetics*; D006801:Humans; D008648:Mesoderm / Q000166:cytology; D008969:Molecular Sequence Data; D009046:Motor Neurons / Q000166:cytology; D009154:Mutation; D009672:Notochord / Q000196:embryology*; D011506:Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000096:biosynthesis; D013234:Stem Cells / Q000166:cytology; D013623:Tail; D015534:Trans-Activators / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*; D029867:Xenopus Proteins; D015027:Zebrafish; D029961:Zebrafish Proteins
D017931:DNA Primers; D004268:DNA-Binding Proteins; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins; C080209:Not protein, Xenopus; D011506:Proteins; D012333:RNA, Messenger; D015534:Trans-Activators; D014157:Transcription Factors; D029867:Xenopus Proteins; D029961:Zebrafish Proteins; C096660:noto protein, zebrafish