Evaluation of polysaccharides intended for ophthalmic use in ocular dosage forms.
Different water-soluble polysaccharides were evaluated for their intended use in ocular dosage forms. The physicochemical characteristics and the viscosity of the solutions prepared with several iso-osmotic vehicles were measured. The influence of ions present in lacrimal fluid, mucin and cyclodextrin on the rheological behaviour was examined. Scleroglucan and xanthan gum exhibit viscoelastic and mucoadhesive properties useful for ocular dosage form formulations.
D003505:Cyclodextrins / Q000737:chemistry; D006801:Humans; D009883:Ophthalmic Solutions / Q000737:chemistry*; D009994:Osmolar Concentration; D014677:Pharmaceutical Vehicles; D011134:Polysaccharides / Q000737:chemistry*; D012212:Rheology; D014783:Viscosity
D003505:Cyclodextrins; D009883:Ophthalmic Solutions; D014677:Pharmaceutical Vehicles; D011134:Polysaccharides