High glucose activates protein kinase C and stimulates fibronectin gene expression by enhancing a cAMP response element.
D051698:Activating Transcription Factor 2; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism*; D017362:Cyclic AMP Response Element-Binding Protein / Q000235:genetics; D003928:Diabetic Nephropathies / Q000378:metabolism*; D005353:Fibronectins / Q000096:biosynthesis / Q000235:genetics*; D015870:Gene Expression / Q000187:drug effects; D005920:Glomerular Mesangium / Q000166:cytology / Q000378:metabolism*; D005947:Glucose / Q000494:pharmacology*; D008969:Molecular Sequence Data; D011493:Protein Kinase C / Q000378:metabolism*; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics; D051381:Rats; D015398:Signal Transduction; D013755:Tetradecanoylphorbol Acetate; D014157:Transcription Factors; D014158:Transcription, Genetic
D051698:Activating Transcription Factor 2; D017362:Cyclic AMP Response Element-Binding Protein; D005353:Fibronectins; D016760:Proto-Oncogene Proteins c-fos; D014157:Transcription Factors; D000242:Cyclic AMP; D011493:Protein Kinase C; D005947:Glucose; D013755:Tetradecanoylphorbol Acetate