title: Combined growth hormone (GH) and insulin-like growth factor-I (IGF-I) treatment is more effective than GH or IGF-I alone at enhancing recovery from neonatal malnutrition in rats.
abstract: The effect of hormonal therapy on enhancing recovery from neonatal malnutrition was assessed in rats. Malnutrition was induced by maternal food restriction (60% control intake) during lactation. On d 16 postpartum, restricted pups were refed by cross-fostering to control dams and were subcutaneously administered growth hormone (GH), insulin-like growth factor-I (IGF-I), GH + IGF-I or saline. At d 21, pups were weaned and continued hormonal treatments until d 39 postpartum. By d 39, body weight of GH (96% control) and GH + IGF-I- (98%) treated animals were normal, whereas IGF-I (88%) and saline- (85%) treated animals were still stunted. Hormone effectiveness was age dependent, with growth rates of GH + IGF-I-, IGF-I- and GH-treated pups being greatest between d 16 and 30, d 16 and 21 and after d 30, respectively. Protein accretion by d 39 was higher (P < 0.01) in GH and GH + IGF-I groups than saline- or IGF-I-treated groups. On d 39, serum IGF-I concentrations were as follows: GH + IGF-I > IGF-I > GH = saline (placebo), indicating that an elevated serum IGF-I was not required for GH-stimulated growth. Of the three hormonal treatments, GH + IGF-I therapy was most efficacious at promoting rapid and complete body weight recovery and supporting lean body mass accretion.
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001823:Body Composition / Q000187:drug effects / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D004195:Disease Models, Animal; D004357:Drug Synergism; D004435:Eating / Q000502:physiology; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000235:genetics / Q000627:therapeutic use*; D007328:Insulin / Q000097:blood; D018971:Insulin-Like Growth Factor Binding Protein 2 / Q000032:analysis / Q000097:blood / Q000235:genetics; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000032:analysis / Q000097:blood / Q000235:genetics; D018974:Insulin-Like Growth Factor Binding Protein 4 / Q000032:analysis / Q000097:blood / Q000235:genetics; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000235:genetics / Q000627:therapeutic use*; D007668:Kidney / Q000033:anatomy & histology / Q000737:chemistry / Q000378:metabolism; D008099:Liver / Q000033:anatomy & histology / Q000737:chemistry / Q000378:metabolism; D008297:Male; D009748:Nutrition Disorders / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology; D009929:Organ Size; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012727:Sex Characteristics; D015430:Weight Gain / Q000502:physiology
chemical_list: D007328:Insulin; D018971:Insulin-Like Growth Factor Binding Protein 2; D018972:Insulin-Like Growth Factor Binding Protein 3; D018974:Insulin-Like Growth Factor Binding Protein 4; D012333:RNA, Messenger; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone