Continuous versus intermittent bladder irrigation of amphotericin B for the treatment of candiduria.
OBJECTIVE
The efficacy of continuous versus intermittent bladder irrigation with amphotericin B in the treatment of candiduria was compared.


METHODS
A prospective, randomized and comparative pilot study was done on 20 patients. Continuous bladder irrigation with 50 mg./l. amphotericin B infused during 24 hours for 2 days was compared to 3 intermittent bladder irrigations of 10 mg./100 ml. amphotericin B in 1 day. Urine cultures were obtained 72 hours after treatment.


RESULTS
The organism was eradicated in 8 patients (80%) who received continuous irrigation and 3 (30%) who received intermittent irrigation (p = 0.035).


CONCLUSIONS
Continuous amphotericin B bladder irrigation was superior in terms of efficacy, ease of administration and patient comfort.
D000368:Aged; D000369:Aged, 80 and over; D000666:Amphotericin B / Q000008:administration & dosage*; D000935:Antifungal Agents / Q000008:administration & dosage*; D002175:Candida / Q000302:isolation & purification; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011446:Prospective Studies; D007507:Therapeutic Irrigation / Q000379:methods; D001743:Urinary Bladder; D014552:Urinary Tract Infections / Q000188:drug therapy*; D014556:Urine / Q000382:microbiology
D000935:Antifungal Agents; D000666:Amphotericin B