[Cognition disorders and parkinsonian syndrome: diffuse Lewy body disease?].
A 68 year old man developed progressive cognitive impairment with an akinetic-rigid syndrome which was atypically responsive to levodopa. The patient died after 18 months and the postmortem examination showed typical Lewy bodies in the substantia nigra and pale bodies in the cortex which were unlabelled by ubiquitin antibodies. This case is particular by the neuropathological examination (no immunoreactivity to antibodies against ubiquitin) and by the abnormal response to treatment (dystonia). These two aspects are discussed.
D000368:Aged; D001921:Brain / Q000473:pathology; D003072:Cognition Disorders / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D004421:Dystonia / Q000139:chemically induced; D006801:Humans; D007980:Levodopa / Q000009:adverse effects / Q000627:therapeutic use; D016631:Lewy Bodies / Q000473:pathology; D008297:Male; D009474:Neurons / Q000648:ultrastructure; D010300:Parkinson Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D010302:Parkinson Disease, Secondary / Q000188:drug therapy / Q000209:etiology / Q000473:pathology
D007980:Levodopa
Troubles cognitifs et syndrome parkinsonien: maladie a corps de Lewy diffus?.