Transforming growth factor-beta 3 is required for secondary palate fusion.
Mice lacking TGF-beta 3 exhibit an incompletely penetrant failure of the palatal shelves to fuse leading to cleft palate. The defect appears to result from impaired adhesion of the apposing medial edge epithelia of the palatal shelves and subsequent elimination of the mid-line epithelial seam. No craniofacial abnormalities were observed. This result demonstrates that TGF-beta 3 affects palatal shelf fusion by an intrinsic, primary mechanism rather than by effects secondary to craniofacial defects.
D000818:Animals; D001483:Base Sequence; D002972:Cleft Palate / Q000196:embryology / Q000235:genetics*; D003598:Cytoskeletal Proteins / Q000032:analysis; D004268:DNA-Binding Proteins / Q000032:analysis; D016326:Extracellular Matrix Proteins / Q000032:analysis; D051956:Goosecoid Protein; D018398:Homeodomain Proteins; D008648:Mesoderm; D051379:Mice; D008810:Mice, Inbred C57BL; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D009024:Morphogenesis; D010159:Palate / Q000737:chemistry / Q000196:embryology*; D012097:Repressor Proteins; D014157:Transcription Factors; D016212:Transforming Growth Factor beta / Q000032:analysis / Q000502:physiology*
D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; D016326:Extracellular Matrix Proteins; D051956:Goosecoid Protein; C497993:Gsc protein, mouse; D018398:Homeodomain Proteins; D012097:Repressor Proteins; D014157:Transcription Factors; D016212:Transforming Growth Factor beta