Gene for the catalytic subunit of mouse DNA-dependent protein kinase maps to the scid locus.
The gene encoding the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) has been proposed recently as a candidate gene for the mouse severe combined immune deficiency (scid) locus. We have used a partial cDNA clone for human DNA-PKcs to map the mouse homologue using a large interspecific backcross panel. We found that the mouse gene for DNA-PKcs does not recombine with scid, consistent with the hypothesis that scid is a mutation in the mouse gene for DNA-PKcs.
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins; D051379:Mice; D016513:Mice, SCID / Q000235:genetics*; D008969:Molecular Sequence Data; D009115:Muridae; D009154:Mutation; D011110:Polymorphism, Genetic; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D011995:Recombination, Genetic; D016511:Severe Combined Immunodeficiency / Q000235:genetics*
D004268:DNA-Binding Proteins; D051747:DNA-Activated Protein Kinase; D017346:Protein Serine-Threonine Kinases