title: Sporadic meningococcal disease in adults: results of a 5-year population-based study.
abstract: OBJECTIVE
  To define the incidence, demographics, clinical features, and risk factors for sporadic meningococcal disease in adults (> or = 18 years) residing in metropolitan Atlanta.
  
  
  METHODS
  Prospective, population-based surveillance, with retrospective review of clinical and laboratory records.
  
  
  METHODS
  Eight-county metropolitan Atlanta area.
  
  
  METHODS
  All adult patients in whom Neisseria meningitidis was isolated from normally sterile sites (blood, cerebrospinal fluid) during the period 1 December 1988 to 30 November 1993.
  
  
  METHODS
  Incidence, relative risk, clinical and laboratory parameters, and serogroup of meningococcal isolates.
  
  
  RESULTS
  For the 5-year period, 44 (33%) of 132 cases of meningococcal disease in Atlanta occurred in adults (annual incidence, 0.50/100,000 adults per year). Twenty-three (52%) of the 44 adults presented without rash or meningitis, the two most obvious signs of meningococcal disease. Pneumonia, sinusitis, or purulent tracheobronchitis, but without rash, were the likely sources of meningococcal bacteremia in 15 (34%) of the 44 adults. Twelve of the 15 patients with meningococcal respiratory infection were older than 50 years of age or were immunocompromised (or both), and three fourths of the 15 patients had disease caused by serogroups B, Y, and W-135. Overall, two thirds of adults older than 24 years of age with meningococcal disease had one or more immunocompromising conditions (for example, low complement 50 level [CH50], corticosteroid use, congestive heart failure, multiple myeloma, human immunodeficiency virus infection). Meningococcemia or meningococcal meningitis, often caused by serogroup C, were the presentations in 14 of 15 adults 18 to 24 years old; only 2 had an identified underlying condition.
  
  
  CONCLUSIONS
  In this 5-year population-based study, one third of all cases of sporadic meningococcal disease occurred in adults. Over half of the adults presented without rash or meningitis. Pneumonia, sinusitis, and tracheobronchitis are important sources of bacteremic meningococcal disease, especially in immunocompromised patients and elderly persons.
mesh_terms: D000293:Adolescent; D000328:Adult; D016470:Bacteremia / Q000453:epidemiology / Q000276:immunology; D005845:Georgia / Q000453:epidemiology; D006801:Humans; D016867:Immunocompromised Host; D015994:Incidence; D008589:Meningococcal Infections / Q000453:epidemiology* / Q000276:immunology; D009345:Neisseria meningitidis; D011446:Prospective Studies; D012189:Retrospective Studies; D012307:Risk Factors