Efficacy of the herbicide trifluralin against four P-glycoprotein-expressing strains of Leishmania.
Drug resistance has emerged as a major obstacle to chemotherapy for many infectious diseases. Trifluralin, an antimicrotubule herbicide, is a new experimental drug for treatment of leishmaniasis. Here, we found that it was effective against two strains of Leishmania that express the multidrug-resistant genes ldmdr1 and lmpgpA and two strains that express proteins that are immunologically cross-reactive with mammalian P glycoproteins. These results suggest that trifluralin is not subject to counteractions of these multidrug resistance mechanisms of Leishmania species.
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001426:Bacterial Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology; D018432:Drug Resistance, Multiple / Q000235:genetics; D007893:Leishmania donovani / Q000187:drug effects* / Q000235:genetics; D018320:Leishmania major / Q000187:drug effects* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D014162:Transfection; D014274:Trifluralin / Q000494:pharmacology*
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D001426:Bacterial Proteins; D014274:Trifluralin