Large scale database experiments to assess the significance of matching DNA profiles.
Over 5,700 three-probe VNTR DNA profiles collected by several United Kingdom (UK) laboratories have been compared to examine the probability of randomly matching 2 samples from different individuals. In over 16 million comparisons, using a matching rule corresponding to the matching guideline employed by the UK Forensic Science Service, no profiles were found to match at the 3 loci D1S7 (MS1), D7S21(MS31) and D12S11 (MS43a). The frequency of occurrence of a set of Caucasian profiles have been estimated with 6 reference databases. The results show that there were greater differences in the frequency estimates when using a database of Afro-Caribbean or Asian profiles, rather than a different Caucasian database. The results further demonstrate the power and robustness of the VNTR DNA profiling technique for forensic casework.
D001499:Bayes Theorem; D016172:DNA Fingerprinting / Q000379:methods / Q000706:statistics & numerical data*; D016208:Databases, Factual; D005819:Genetic Markers; D006801:Humans; D018598:Minisatellite Repeats; D008957:Models, Genetic; D012150:Polymorphism, Restriction Fragment Length; D011336:Probability; D044469:Racial Groups; D012016:Reference Values; D015203:Reproducibility of Results; D006113:United Kingdom
D005819:Genetic Markers