title: [Topoisomerase I inhibitors. Review of phase II trials with irinotecan (CPT-11) and topotecan].
abstract: Topoisomerase I inhibitors are a new therapeutic class whose clinical evaluation began a few years ago; Irinotecan (CPT-11) gave interesting results in colon cancer; side effects were neutropenia, diarrhea, vomiting and a cholinergic syndrome. Topotecan was useful in lung and ovarian cancer; side effects were mostly hematologic. Undergoing studies concern dose optimization, mode of administration and therapeutic associations.
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002166:Camptothecin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D017322:Clinical Trials, Phase II as Topic; D003967:Diarrhea / Q000139:chemically induced; D004334:Drug Administration Schedule; D006801:Humans; D000077146:Irinotecan; D009369:Neoplasms / Q000188:drug therapy*; D009503:Neutropenia / Q000139:chemically induced; D059004:Topoisomerase I Inhibitors; D019772:Topotecan; D014839:Vomiting / Q000139:chemically induced
chemical_list: D000970:Antineoplastic Agents; D059004:Topoisomerase I Inhibitors; D000077146:Irinotecan; D019772:Topotecan; D002166:Camptothecin
vernacular_title: Les inhibiteurs de la topo-isomérase I. Revue des essais de phase II de l'irinotécan (CPT-11) et du topotécan.