Effects of catechins on the mouse tumor cell adhesion to fibronectin.
We studied the effects of 5 kinds of catechins on the adhesion of mouse lung carcinoma 3LL and melanoma B16F10 cells to the fibronectin substratum. (-)-Epicatechin gallate and (-)-epigallocatechin gallate were active in inhibiting the 3LL cell adhesion, while (+)-catechin, (-)-epicatechin, and (-)-epigallocatechin were inactive. Gallate-containing catechins also impaired adhesion and/or spreading of B16F10 cells.
D000818:Animals; D001665:Binding Sites; D002392:Catechin / Q000031:analogs & derivatives / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects*; D005353:Fibronectins / Q000378:metabolism*; D008175:Lung Neoplasms / Q000473:pathology*; D008546:Melanoma, Experimental / Q000473:pathology*; D051379:Mice; D014407:Tumor Cells, Cultured
D005353:Fibronectins; D002392:Catechin; C062669:epicatechin gallate; C045651:epigallocatechin gallate