Leucine-enkephalin and methionine-enkephalin produce opposing effects on plasma corticosterone levels in ether-stressed mice.
The inhibitory effects of intracerebroventricular administration of saline on the plasma corticosterone response to ether stress in mice was reduced by Met-enkephalin and enhanced by Leu-enkephalin. When administered simultaneously the effects of the two peptides opposed each other. Met and Leu-enkephalin may subserve different physiological functions in the response of the hypothalamus-pituitary-adrenal system to stress.
D000818:Animals; D003345:Corticosterone / Q000097:blood*; D004723:Endorphins / Q000494:pharmacology*; D004743:Enkephalin, Leucine; D004744:Enkephalin, Methionine; D004745:Enkephalins / Q000494:pharmacology*; D004986:Ether / Q000037:antagonists & inhibitors*; D005019:Ethyl Ethers / Q000037:antagonists & inhibitors*; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology; D008297:Male; D051379:Mice; D010913:Pituitary-Adrenal System / Q000503:physiopathology; D013312:Stress, Physiological / Q000503:physiopathology*
D004723:Endorphins; D004745:Enkephalins; D005019:Ethyl Ethers; D004986:Ether; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D003345:Corticosterone