Expression of alpha-fetoprotein by ovarian Sertoli-Leydig cell tumors. Case report and review of the literature.
A 17-year-old girl had an ovarian Sertoli-Leydig cell tumor associated with elevation of the serum alpha-fetoprotein level. On microscopic examination, the tumor had a predominantly spindled cellular stroma containing open and solid tubules, focal clusters of hepatoid cells, and heterologous carcinoid. Alpha-fetoprotein was demonstrated within the hepatoid cells by immunohistochemical techniques. After surgery, serum alpha-fetoprotein level fell to normal, and the patient is still free of tumor 8 months later.
D000293:Adolescent; D002454:Cell Differentiation; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D010051:Ovarian Neoplasms / Q000378:metabolism* / Q000473:pathology*; D012708:Sertoli Cells / Q000473:pathology; D018310:Sertoli-Leydig Cell Tumor / Q000378:metabolism* / Q000473:pathology*; D016708:Synaptophysin / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis / Q000096:biosynthesis*
D016708:Synaptophysin; D000509:alpha-Fetoproteins