title: [The human genome--chromosome 18].
abstract: The 18th human chromosome is probably known mainly due to patients with Edwards syndrome, children dying usually during the first week of life, the syndrome being due to the presence of three chromosomes 18-trisomy. Some of its loci participate in oncogenesis either as cellular oncogenes (BCL2 in lymphomas), or antioncogenes (DCC--in colorectal carcinomas--Lynch I and Lynch II). It is assumed that some of the causes of maniac depression could be associated with chromosome no. 18.
mesh_terms: D002887:Chromosomes, Human, Pair 18; D005826:Genetics, Medical; D006801:Humans
vernacular_title: Lidský genom--chromozom c. 18.