Changes in the ultrastructure and functions of immunocompetent cells under the influence of external heating, interleukin 1 beta and leukocytic pyrogen.
The structural and functional organization of the rabbit immunocompetent cells after injection of human recombinant interleukin 1 beta (IL-1 beta), partially purified leukocytic pyrogen (LP), or after external heating (36 degrees C, 1.5 h) was compared. A rectal temperature increase being the same, there were similar and transient changes in epithelial and endothelial cells and macrophages, a rise in the proliferative activity of thymocytes and synthesis of IL-1-like activity, and a decrease in the interleukin 2 (IL-2) production by cultured splenic cells.
D000818:Animals; D004730:Endothelium, Vascular / Q000648:ultrastructure*; D004848:Epithelium / Q000648:ultrastructure; D005334:Fever / Q000139:chemically induced* / Q000276:immunology; D006358:Hot Temperature; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis / Q000494:pharmacology*; D008264:Macrophages / Q000276:immunology / Q000648:ultrastructure*; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D011817:Rabbits; D011994:Recombinant Proteins / Q000494:pharmacology; D013154:Spleen; D013601:T-Lymphocytes / Q000276:immunology / Q000648:ultrastructure*
D007375:Interleukin-1; D011994:Recombinant Proteins; C008270:leukocyte endogenous mediator