CETP and LCAT activities are unrelated to smoking and moderate alcohol consumption in healthy normolipidemic men.
To distinguish between the effects of smoking and drinking on lipid metabolism, we conducted a cross-sectional study using 52 healthy normolipidemic subjects who either smoked or drank, but not both. The subjects were divided into three groups: Group S, smokers who did not drink (n = 20); Group D, drinkers who did not smoke (n = 12); and Group C, controls (n = 20), who neither drank nor smoked. High density lipoprotein cholesterol (HDL-C) levels and plasma cholesteryl ester transfer protein (CETP) and lecithin: cholesterol acyltransferase (LCAT) activities were measured in all of the subjects, and the values obtained in Group S and Group D were compared to those of controls. Group S had lower (p < 0.01) HDL2-C and HDL3-C levels, and Group D had higher (p < 0.05) HDL2-C and HDL3-C levels than the controls, but there were no significant differences between groups with respect to CETP and LCAT activities. Thus, in healthy normolipidemic men, both smoking and drinking affect HDL-C levels as expected, but do not affect plasma CETP or LCAT activity levels.
D000328:Adult; D000428:Alcohol Drinking / Q000378:metabolism*; D001053:Apolipoproteins / Q000097:blood; D002352:Carrier Proteins / Q000378:metabolism*; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL / Q000097:blood; D003430:Cross-Sectional Studies; D006023:Glycoproteins; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000378:metabolism*; D012907:Smoking / Q000378:metabolism*
D001053:Apolipoproteins; C506642:CETP protein, human; D002352:Carrier Proteins; D053480:Cholesterol Ester Transfer Proteins; D008076:Cholesterol, HDL; D006023:Glycoproteins; D008055:Lipids; D007862:Phosphatidylcholine-Sterol O-Acyltransferase