Could standardized cavernosometry be helpful in therapeutic management of veno-occlusive dysfunction?
OBJECTIVE
Due to the lack of a gold standard for performing cavernosometry, we selected 30 patients with veno-occlusive dysfunction to evaluate the internal relationships of cavernosometric parameters and their reliability for therapeutic decisions.


METHODS
Cavernosometry was performed after injection of 20 to 40 micrograms of prostaglandin E1. Maintenance flow rates, intracavernous pressure decay following cessation of flow and intracavernous pressure changes after compression maneuvers were the main parameters considered.


RESULTS
Cavernosometric results were standardized as grade 1-7 patients with maintenance flow rate less than 20 ml. per minute (mean 18 +/- 2.5) and intracavernous pressure decay 27.5 +/- 15%, grade 2-11 with maintenance flow rates significantly lower (p < 0.001) than grade 1 (mean 37 +/- 11 ml. per minute) and intracavernous pressure decay 33 +/- 20%, and grade 3-12 with only recorded induction flows greater than 70 ml. per minute and intracavernous pressure less than 50 mm. Hg. A strong statistical correlation (p < 0.01) was noted between maintenance flow rate and percent of intracavernous pressure decays.


CONCLUSIONS
These parameters allowed us to choose different therapies, such as complex venous surgery, mixed pharmacotherapy or prosthetic implants. Good sexual function was restored in 85% of the cases. We can conclude that our model of standardized cavernosometry has made easier the therapeutic choices in patients who do not respond to intracavernous drugs.
D000328:Adult; D000527:Alprostadil; D001783:Blood Flow Velocity / Q000502:physiology; D006801:Humans; D018783:Impotence, Vasculogenic / Q000175:diagnosis* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010410:Penile Erection / Q000187:drug effects / Q000502:physiology; D010413:Penis / Q000098:blood supply / Q000502:physiology; D011312:Pressure; D012039:Regional Blood Flow / Q000502:physiology; D012965:Sodium Chloride; D014665:Vasodilator Agents
D014665:Vasodilator Agents; D012965:Sodium Chloride; D000527:Alprostadil