Lymphoid malignancies following Kawasaki disease.
Kawasaki disease is a childhood multisystem vasculitic syndrome of unknown etiology. Associated immunological dysregulation is consistently observed and may be pathogenic in the known cardiac and noncardiac complications of the disease. Despite the well-known association between acquired immunodeficiency states and neoplasia, there are no reports of cancer accompanying or following the onset of this disease. We report here two children who were diagnosed with lymphoid malignancies shortly following the diagnosis of Kawasaki disease, suggesting an association between the two entities.
D002648:Child; D002675:Child, Preschool; D006689:Hodgkin Disease / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology