Pressor and reflex sensitivity is altered in spontaneously hypertensive rats treated with angiotensin-(1-7).
We have suggested that angiotensin-(1-7) [Ang-(1-7)] may oppose the pressor activity of angiotensin II (Ang II). This hypothesis was supported by the fact that long-term intravenous infusion of Ang-(1-7) transiently lowers blood pressure in spontaneously hypertensive rats (SHR). We now investigated whether the pressor sensitivity to bolus injections of either phenylephrine (PE) or Ang II was altered on day 12 of an Ang-(1-7) infusion when blood pressure in the SHR had returned to hypertensive levels. SHR (n = 10) and WKY rats (n = 8) were given Ang-(1-7) intravenously via osmotic minipumps at a dose of 24 micrograms/kg per hour for 2 weeks. On day 12 of the infusion, mean arterial pressure and heart rate in halothane-anesthetized rats were similar in Ang-(1-7)-treated SHR (142 +/- 6 mm Hg; 388 +/- 9 beats per minute) and those infused with vehicle (146 +/- 5 mm Hg; 392 +/- 13 beats per minute). Pressor responsiveness to PE in Ang-(1-7)-treated SHR was 22% less at a dose of 10 micrograms, while pressor responses to Ang II decreased by 20% and 25% at doses of 0.05 and 0.1 micrograms, respectively, compared with the vehicle-treated SHR (P < .05). There were no effects of the Ang-(1-7) infusion on pressor responses to Ang II or PE in WKY rats.(ABSTRACT TRUNCATED AT 250 WORDS)
D000803:Angiotensin I; D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology*; D007262:Infusions, Intravenous; D007275:Injections, Intravenous; D008297:Male; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology; D011311:Pressoreceptors / Q000187:drug effects*; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012018:Reflex / Q000187:drug effects*; D013997:Time Factors; D014662:Vasoconstrictor Agents / Q000008:administration & dosage / Q000494:pharmacology
D010446:Peptide Fragments; D014662:Vasoconstrictor Agents; D000804:Angiotensin II; D010656:Phenylephrine; D000803:Angiotensin I; C118790:angiotensin I (1-7)