[Gene therapy].
This paper considers the prerequisites for gene therapy. This new field of therapeutics has not yet proved its efficacity nor its safety. Use, as a drug of DNA molecules which can modify host genome and environment as well requires specific prerequisites; among them, animal experimental models are essential despite their limitations. The different preclinical and clinical steps in the design of gene therapy studies are also discussed.
D000818:Animals; D002986:Clinical Trials as Topic; D004353:Drug Evaluation, Preclinical; D005602:France; D015316:Genetic Therapy / Q000639:trends; D006801:Humans; D066298:In Vitro Techniques
Thérapie génique.