[The effect of subinhibitory concentrations of norfloxacin, erythromycin and roxithromycin on Pseudomonas aeruginosa virulence factors].
The effect of sub-MICs (1/4 MIC, 1/8 MIC, 1/16 MIC) of norfloxacin, erythromycin, roxithromycin on Pseudomonas aeruginosa virulence factors was studied. It was found that 1/4 of the MIC of norfloxacin inhibited most effectively elastase as well as proteinase activity (to 30.1% or 29.2% of the control values). Macrolide antibiotics did not reduce the tested enzymic activities but caused their increase.
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology*; D010450:Endopeptidases / Q000378:metabolism; D004917:Erythromycin / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D009643:Norfloxacin / Q000494:pharmacology*; D010196:Pancreatic Elastase / Q000378:metabolism; D011550:Pseudomonas aeruginosa / Q000187:drug effects / Q000201:enzymology / Q000472:pathogenicity*; D015575:Roxithromycin / Q000494:pharmacology*; D014774:Virulence / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D015575:Roxithromycin; D004917:Erythromycin; D010450:Endopeptidases; D010196:Pancreatic Elastase; D009643:Norfloxacin
Vplyv subinhibicných koncentrácií norfloxacínu, erytromycínu a roxitromycínu na faktory virulencie Pseudomonas aeruginosa.