Mechanism of insulin and IGF-I receptor activation and signal transduction specificity. Receptor dimer cross-linking, bell-shaped curves, and sustained versus transient signaling.
D000818:Animals; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000378:metabolism; D004789:Enzyme Activation; D066246:ErbB Receptors / Q000737:chemistry / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology; D007334:Insulin-Like Growth Factor I / Q000378:metabolism / Q000494:pharmacology / Q000502:physiology; D007700:Kinetics; D008024:Ligands; D046911:Macromolecular Substances; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases; D008961:Models, Structural; D008962:Models, Theoretical; D017526:Receptor, IGF Type 1 / Q000737:chemistry / Q000502:physiology*; D011972:Receptor, Insulin / Q000737:chemistry / Q000502:physiology*; D018121:Receptors, Cytokine / Q000737:chemistry / Q000502:physiology; D017479:Receptors, Platelet-Derived Growth Factor / Q000737:chemistry / Q000502:physiology; D015290:Second Messenger Systems; D015398:Signal Transduction; D013379:Substrate Specificity
D007328:Insulin; D008024:Ligands; D046911:Macromolecular Substances; D018121:Receptors, Cytokine; D007334:Insulin-Like Growth Factor I; D066246:ErbB Receptors; D017526:Receptor, IGF Type 1; D011972:Receptor, Insulin; D017479:Receptors, Platelet-Derived Growth Factor; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D048052:Mitogen-Activated Protein Kinase 3; D020928:Mitogen-Activated Protein Kinases