The free radical scavenger, alpha-lipoic acid, protects against cerebral ischemia-reperfusion injury in gerbils.
alpha-Lipoic acid (thioctic acid) was tested for its neuroprotective activity in a Mongolian gerbil model of forebrain ischemia/reperfusion. Adult gerbils were treated for 7 days with two intraperitoneal injections per day of alpha-lipoic acid (20 mg/kg), vehicle or saline and on the 7th day the animals were subjected to 5 min of forebrain ischemia. Ischemic injury was assessed by monitoring the increases in locomotor activity and from the extent of damage to the CA1 hippocampal pyramidal cell layer after 5 days of recovery. By both criteria, alpha-lipoic acid was neuroprotective against ischemia/reperfusion evoked cerebral injury.
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology / Q000517:prevention & control*; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D005849:Gerbillinae; D008124:Locomotion; D015427:Reperfusion Injury / Q000503:physiopathology / Q000517:prevention & control*; D008063:Thioctic Acid / Q000627:therapeutic use*
D016166:Free Radical Scavengers; D008063:Thioctic Acid