Amino acid residue: is it structural or functional?
A new approach is suggested for delineating the structural and functional amino acid residues in proteins with known three-dimensional structure, basing on the involvement of residues in intramolecular hydrophobic and hydrophilic interactions and additional information about the conservativity of the residues. The approach is applied to the families of homologous neurotoxins and cardiotoxins. The results obtained concerning the role of amino acid residues in both families of toxins accord well with the similarity of their fold, but different mechanisms of action. Current approach can be used for detailed characterization of protein spatial structures, as well as for rational protein engineering.
D000595:Amino Acid Sequence; D000596:Amino Acids; D008969:Molecular Sequence Data; D009498:Neurotoxins / Q000737:chemistry; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism*; D017386:Sequence Homology, Amino Acid; D012910:Snake Venoms / Q000737:chemistry*
D000596:Amino Acids; D009498:Neurotoxins; D011506:Proteins; D012910:Snake Venoms