Cure of prophage in Staphylococcus aureus by furocoumarin photoadditions.
In a previous report curing of prophage in Staphylococcus aureus by treatment with 8-methoxypsoralen plus near-UV (365 nm) radiation was described. In the present work the use of angelicin and 4,5',8-trimethylpsoralen and repeated irradiation show that monoadducts and DNA interstrand cross-links formed by furocoumarin photoaddition are involved in the curing of the prophage responsible for the suppression of the lipolytic activity in a putative repair proficient strain of Staphylococcus aureus.
D018736:DNA Adducts; D004269:DNA, Bacterial / Q000187:drug effects / Q000528:radiation effects; D011564:Furocoumarins / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000494:pharmacology*; D013204:Staphylococcus Phages / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000187:drug effects / Q000528:radiation effects / Q000821:virology*; D014307:Trioxsalen / Q000494:pharmacology; D014466:Ultraviolet Rays
D018736:DNA Adducts; D004269:DNA, Bacterial; D011564:Furocoumarins; D017319:Photosensitizing Agents; C011659:angelicin; D014307:Trioxsalen