[AIDS dementia. Prognosis and therapeutic perspectives].
AIDS dementia complex is a severe complication related to HIV infection of the central nervous system. It has been estimated to affect about 7% of AIDS patients, with an increased frequency in very young and old patients. In most cases, it appears in severely immuno-deficient patients. Typically, AIDS dementia presents as a subcortical dementia with cognitive, behavioural and motor decline. The mechanism of the dementia remains unclear; the neuronal loss is controversial and a neurotoxicity due to NMDA receptor activation is likely. No treatment proved to be efficient. Beneficial effect of anti-NMDA receptor antagonists are under investigation.
D015526:AIDS Dementia Complex / Q000188:drug therapy / Q000503:physiopathology / Q000628:therapy*; D000328:Adult; D000367:Age Factors; D006801:Humans; D008875:Middle Aged; D009474:Neurons / Q000473:pathology; D011379:Prognosis; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000502:physiology
D016194:Receptors, N-Methyl-D-Aspartate
Démence du SIDA. Evolution et perspectives thérapeutiques.