Activity of penciclovir against Epstein-Barr virus.
Penciclovir inhibited the productive replication cycle of Epstein-Barr virus (EBV) in assays measuring infectious virus production, viral antigen expression, and viral DNA synthesis. In the test measuring inhibition of EBV DNA synthesis, 50% effective concentrations of penciclovir and acyclovir were 2.3 +/- 0.8 and 2.2 +/- 0.6 micrograms/ml, respectively. The 50% cell growth inhibitory concentration of penciclovir was > 100 micrograms/ml for both P3HR-1 and Raji cells. Penciclovir is a selective inhibitor of EBV in cell culture.
D000212:Acyclovir / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D000956:Antigens, Viral / Q000032:analysis; D000998:Antiviral Agents / Q000494:pharmacology* / Q000633:toxicity; D001402:B-Lymphocytes / Q000821:virology; D002478:Cells, Cultured; D004279:DNA, Viral / Q000187:drug effects; D004797:Enzyme-Linked Immunosorbent Assay; D006147:Guanine; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D014779:Virus Replication / Q000187:drug effects
D000956:Antigens, Viral; D000998:Antiviral Agents; D004279:DNA, Viral; C053539:penciclovir; D006147:Guanine; D000212:Acyclovir