title: [Trophoblastic interferons and embryonal immune tolerance].
abstract: Current evidence support the hypothesis that trophoblast interferons play a key role in preventing maternal immunologal rejection of the embryonic semi-allograft. The information of this review is divided in two sections. In the first section we described molecular and biological characteristics of type I (alpha, beta, omega, tau and spl) and type II (gamma) interferons. In the second section we emphasize studies on immunoendocrine functions of IFN-tau (oTP-1 or trophoblastins) in the network of cytokines and hormonal environment at the uterine embryonic interface.
mesh_terms: D000818:Animals; D004622:Embryo, Mammalian / Q000276:immunology*; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D007370:Interferon Type I / Q000276:immunology; D007371:Interferon-gamma / Q000276:immunology; D007372:Interferons / Q000145:classification / Q000276:immunology*; D008431:Maternal-Fetal Exchange / Q000276:immunology*; D010802:Phylogeny; D011247:Pregnancy; D014327:Trophoblasts / Q000276:immunology*
chemical_list: D007370:Interferon Type I; D007371:Interferon-gamma; D007372:Interferons
vernacular_title: Les interférons trophoblastiques et la tolérance immunologique embryonnaire.