Preventive effect of long-term aerobic exercise on thrombus formation in rat cerebral vessels.
The antithrombotic effect of long-term aerobic exercise was studied in rat cerebral blood vessels using an argon (Ar) laser-induced thrombosis technique. Rats were subjected to treadmill exercise at 70% VO2max for 2 and 4 months. The number of laser irradiations required to form an occlusive thrombus in the exercise group was significantly increased compared to that of the control group after 2- and 4-month training periods. Fibrinolytic activity increased just after exercise but there was no significant difference between the exercise and the control group in the resting state after a period of exercising conditioning. The results demonstrated that long-term aerobic exercise decreased the thrombotic tendency in rat cerebral vessels and suggested that such exercise might have a protective effect on these blood vessels.
D000332:Aerobiosis; D000818:Animals; D001160:Arterioles / Q000293:injuries; D001780:Blood Coagulation Tests; D005342:Fibrinolysis; D002542:Intracranial Embolism and Thrombosis / Q000209:etiology / Q000517:prevention & control*; D007834:Lasers / Q000009:adverse effects; D008297:Male; D010805:Physical Conditioning, Animal / Q000502:physiology*; D010841:Pia Mater / Q000098:blood supply; D010974:Platelet Aggregation; D051381:Rats; D017208:Rats, Wistar; D014664:Vasodilation