[A multivariate genetic analysis of the data from a complex study of the predisposition to schizophrenia].
49 families of schizophrenics (49 probands and their 106 first-degree relatives) were studied by means of psychological methods, EEG and computed tomography. Multivariate genetic analysis were performed to assess genetic and environmental components of parameter phenotypic variance and relations between the parameters and liability to schizophrenia, including formation of discriminant functions for classification of individuals into high risk and normal groups and estimation of the functions heritability. Besides, correlations between parameters of neuromorphological, neurophysiological and psychological levels were calculated. The heritability of most EEG and CT parameters were between 41 and 98%. Among psychological variables only mediated and logic memory seem to be under sufficient genetic control (relatively 62 and 42%). Discriminant functions derived from psychological and EEG parameters, allow to differentiate correctly individuals into high risk and normal groups in 76-88% cases. Results of correlational analysis of psychological and biological variables suggest that there are both system and separate genetically determined abnormalities related to different levels of pathogenesis.
D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D003430:Cross-Sectional Studies; D004198:Disease Susceptibility; D004569:Electroencephalography / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011599:Psychopathology; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012565:Schizophrenic Psychology; D012815:Signal Processing, Computer-Assisted; D014057:Tomography, X-Ray Computed
Mnogomernyĭ geneticheskiĭ analiz dannykh kompleksnogo izucheniia predraspolozhennosti k shizofrenii.