title: Use of lethal body burdens to indicate species differences in susceptibility to narcotic toxicants.
abstract: Lethal body burdens (LBB) for 1,2- and 1,4-dihalogenated benzenes (F, Cl or Br) are determined in rainbow trout of two age-classes. LBBs range from 0.3 to 2.4 mmol/kg. There are no significant differences between the two tested age-classes of rainbow trout. The rainbow trout data are compared to LBBs for 1,2- and 1,4-difluorobenzene in fathead minnow which range from 2.7 to 3.0 mmol/kg, and to LBBs of dichloro- and dibromobenzenes in guppy and fathead minnow [Sijm et al. 1993] which range from 2.7 to 8.0 mmol/kg. Rainbow trout are more susceptible to dihalogenated benzenes than fathead minnow. The LBB can be used as an instrument to examine the intrinsic toxicity of a chemical to a species, and to indicate the susceptibility of a species. Possible reasons for differences in susceptibility among species are discussed.
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001822:Body Burden; D001969:Bromobenzenes / Q000633:toxicity*; D002722:Chlorobenzenes / Q000633:toxicity*; D002851:Chromatography, High Pressure Liquid; D003530:Cyprinidae; D005464:Fluorobenzenes / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D007928:Lethal Dose 50; D017686:Oncorhynchus mykiss; D013045:Species Specificity; D014867:Water / Q000032:analysis / Q000737:chemistry; D014874:Water Pollutants, Chemical / Q000032:analysis
chemical_list: D001969:Bromobenzenes; D002722:Chlorobenzenes; D005464:Fluorobenzenes; D007306:Insecticides; D014874:Water Pollutants, Chemical; D014867:Water; C004726:2-dichlorobenzene; C018511:4-dichlorobenzene