The trypanosomatid Rieske iron-sulfur proteins have a cleaved presequence that may direct mitochondrial import.
We have cloned the gene that encodes subunit 4 of the T. brucei cytochrome-c reductase complex and a fragment of the C. fasciculata subunit 4 cDNA and have shown that subunit 4 is the Rieske iron-sulfur protein. The cleaved presequences of the trypanosomatid iron-sulfur proteins resemble conventional mitochondrial targeting presequences but are smaller than other eukaryotic iron-sulfur protein signal peptides.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001692:Biological Transport; D002451:Cell Compartmentation; D016831:Crithidia fasciculata / Q000378:metabolism; D017931:DNA Primers / Q000737:chemistry; D014450:Electron Transport Complex III; D007506:Iron-Sulfur Proteins / Q000737:chemistry / Q000378:metabolism*; D008928:Mitochondria / Q000378:metabolism*; D008969:Molecular Sequence Data; D009245:NADH Dehydrogenase / Q000737:chemistry / Q000378:metabolism*; D011498:Protein Precursors / Q000378:metabolism; D011499:Protein Processing, Post-Translational; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D014346:Trypanosoma brucei brucei / Q000378:metabolism
D017931:DNA Primers; D007506:Iron-Sulfur Proteins; D011498:Protein Precursors; C037989:Rieske iron-sulfur protein; D009245:NADH Dehydrogenase; D014450:Electron Transport Complex III