title: [Migraine and histamine: determining histidine in plasma and cerebrospinal fluid during migraine attacks].
abstract: We studied the plasma levels and cerebrospinal fluid (CSF) levels in twenty-nine patients suffering from migraine without aura and in eighteen others with aura. The samples were obtained during migraine attacks. We compared the results obtained with those from twenty-seven control subjects. Histidine levels in plasma were 1.18 +/- 0.51 mg/dl for the control group, 1.75 +/- 0.39 mg/dl in those suffering from migraine without aura and 2.07 +/- 0.64 mg/dl in those cases of migraine with aura. In both plasma and in cerebrospinal fluid concentrations of histidine were greater in patients with migraine than in controls (p < 0.001). Histidine is an amino acid precursor of histamine and its abnormalities may be demonstrative of the participation of this amine in migraine attacks, possibly within the state of neuronal hyperexcitability.
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006639:Histidine / Q000097:blood* / Q000134:cerebrospinal fluid*; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood* / Q000134:cerebrospinal fluid
chemical_list: D006639:Histidine
vernacular_title: Migraña e histamina: determinación de histidina en plasma y líquido cefalorraquídeo durante crisis de migraña.