Louisianins A, B, C and D: non-steroidal growth inhibitors of testosterone-responsive SC 115 cells. I. Taxonomy, fermentation, isolation and biological characteristics.
In the course of screening for non-steroidal growth inhibitors of testosterone-responsive Shionogi carcinoma 115 cells, louisianins A, B, C and D, were isolated from fermentation broth of Streptomyces sp. WK-4028. Louisianin A remarkably inhibited the growth of SC 115 cells in the presence of 10(-7) M testosterone at an IC50 value of 0.6 microgram/ml, whereas, no inhibition was observed on the other cell lines. Furthermore, inhibitory activity of testosterone 5 alpha-reductase and antimicrobial activity have not been observed at a concentration of 50 micrograms/ml and 1,000 micrograms/ml, respectively.
D058891:5-alpha Reductase Inhibitors; D000498:Allyl Compounds / Q000302:isolation & purification* / Q000494:pharmacology*; D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D005285:Fermentation; D006131:Growth Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D008297:Male; D008546:Melanoma, Experimental / Q000188:drug therapy; D051379:Mice; D008826:Microbial Sensitivity Tests; D011725:Pyridines / Q000302:isolation & purification* / Q000494:pharmacology*; D051381:Rats; D013302:Streptomyces / Q000145:classification; D014407:Tumor Cells, Cultured / Q000187:drug effects
D058891:5-alpha Reductase Inhibitors; D000498:Allyl Compounds; D000970:Antineoplastic Agents; D006131:Growth Inhibitors; D011725:Pyridines; C096930:louisianin A; C096931:louisianin B; C096932:louisianin C; C096933:louisianin D