Normal CAG and CCG repeats in the Huntington's disease genes of Parkinson's disease patients.
The clinical features of Parkinson's disease, particularly rigidity and bradykinesia and occasionally tremor, are seen in juvenile-onset Huntington's disease. Therefore, the CAG and CCG repeats in the Huntington's disease gene were investigated in 45 Parkinson's disease patients and compared to 40 control individuals. All of the Parkinson's disease chromosomes fell within the normal size ranges. In addition, the distributions of the two repeats in the Parkinson's disease patients did not differ significantly from those of the control population. Therefore, abnormalities of these trinucleotide repeats in the Huntington's disease gene are not likely to contribute to the pathogenesis of Parkinson's disease.
D000368:Aged; D016022:Case-Control Studies; D006801:Humans; D006816:Huntington Disease / Q000235:genetics*; D018598:Minisatellite Repeats; D010300:Parkinson Disease / Q000235:genetics*; D018911:Trinucleotide Repeats