Computer-assisted continuous infusion for the delivery of target-controlled infusions of propofol during outpatient surgery.
Propofol was administered intravenously using a first-order, three-compartment, computer-controlled infusion pump (CCIP) based on the Ohmeda 9000 syringe pump. The CCIP system produced a target-controlled infusion (TCI) based on the estimated blood concentration (EBC). Twenty-five patients undergoing ambulatory surgery completed the study. The induction EBC was 4.72 +/- 0.28 micrograms/ml, and was achieved rapidly with minimal hemodynamic changes. The emergence EBC was 1.55 +/- 0.21 micrograms/ml, and the discharge EBC was 1.06 +/- 0.22 micrograms/ml. The EBC, together with clinical signs, allowed for predictable inductance and emergence from anesthesia using propofol.
D000293:Adolescent; D000328:Adult; D000556:Ambulatory Surgical Procedures; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000097:blood; D004360:Drug Therapy, Computer-Assisted; D005260:Female; D006801:Humans; D007260:Infusion Pumps; D007262:Infusions, Intravenous / Q000295:instrumentation; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage* / Q000097:blood
D018686:Anesthetics, Intravenous; D015742:Propofol