The effect of granulocyte-macrophage colony-stimulating factor on myeloid cells and its clinical applications.
Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a naturally occurring growth factor produced by several cell types in response to a variety of stimuli. GM-CSF has potent stimulatory effects on the growth and maturation of hematopoietic cells and has profound effects on mature circulating effector cells. Clinical applications of GM-CSF include ameliorating chemotherapy-induced neutropenia and enhancing hematopoietic recovery after bone marrow transplantation. This review evaluates the effect of GM-CSF on myeloid cells and its clinical applications.
D000163:Acquired Immunodeficiency Syndrome / Q000628:therapy; D000741:Anemia, Aplastic / Q000628:therapy; D016026:Bone Marrow Transplantation; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D009000:Monocytes / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects*; D015398:Signal Transduction
D016178:Granulocyte-Macrophage Colony-Stimulating Factor