title: D-dimer improves the prognostic value of combined clinical and laboratory data in equine gastrointestinal colic.
abstract: The discriminating ability of 15 parameters alone or in combinations, including results from analysis of plasma endotoxin, the Nycomed plasma D-Dimer test and phospholipase A2, were analyzed to predict morbidity and mortality in equine gastrointestinal colic. Endotoxaemia was a characteristic feature of the colic horses. The problem of adequately predicting nonsurvivors among colic horses required several parameters to be included in the logistic model: if the "classical parameters", (heart rate, respiratory rate, PCV, anion gap) were included in the model, addition of plasma D-dimer, phospholipase A2, and Cl- significantly improved the predictive value of the logistic model. Increasing heart rate and D-dimer together with decreasing chloride was a risk factor for nonsurvival. The sensitivity of this three-parameter logistic model to predict nonsurvival was 78% and specificity 77%. The Nycomed D-Dimer test is recommended as a horse-site test to predict disseminated intravascular coagulation and nonsurvival in equine colic.
mesh_terms: D000818:Animals; D015415:Biomarkers; D003085:Colic / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000662:veterinary*; D004731:Endotoxins / Q000097:blood; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D005767:Gastrointestinal Diseases / Q000097:blood / Q000175:diagnosis / Q000401:mortality / Q000662:veterinary*; D006339:Heart Rate; D006734:Horse Diseases / Q000097:blood / Q000175:diagnosis* / Q000401:mortality; D006736:Horses; D015999:Multivariate Analysis; D010088:Oxidoreductases / Q000097:blood; D010741:Phospholipases A / Q000097:blood; D054467:Phospholipases A2; D011379:Prognosis; D012119:Respiration; D012189:Retrospective Studies
chemical_list: D015415:Biomarkers; D004731:Endotoxins; D005338:Fibrin Fibrinogen Degradation Products; D005340:Fibrinogen; D010088:Oxidoreductases; D010741:Phospholipases A; D054467:Phospholipases A2