The effects of subacute and subchronic oral exposure to cis-1,2-dichloroethylene in Sprague-Dawley rats.
Cis-1,2-dichloroethylene was administered daily by corn oil gavage to male and female Sprague-Dawley rats at the following dose levels: 1.0, 3.0, 10.0 and 22.0 mmol/kg/day for 14 days. Doses gavaged during the 90-day subchronic study were 0.33, 1.00, 3.00 and 9.00 mmol/kg/day. There were no compound-related deaths or histopathological changes demonstrated. Significant increases in relative liver weights were seen after 14- and 90-days of treatment in both sexes. This study demonstrates some indication of toxicity at subacute and subchronic exposure levels as low as 0.33 mmol/kg/day. Implications of liver abnormalities were demonstrated at an exposure level of 1 mmol/kg/day while kidney abnormalities (relative weights) were demonstrated at an exposure level of 0.33 mmol/kg/day.
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004000:Dichloroethylenes / Q000633:toxicity*; D004326:Drinking / Q000187:drug effects; D004334:Drug Administration Schedule; D004435:Eating / Q000187:drug effects; D005260:Female; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D012015:Reference Standards; D013237:Stereoisomerism; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D004000:Dichloroethylenes; D014874:Water Pollutants, Chemical; C035384:1,2-dichloroethylene