The role of iron in beta amyloid toxicity.
There is evidence that oxidative damage plays a causative role in Alzheimer's disease and amyloid beta protein (A beta) toxicity. Iron is frequently a potent facilitator of free radical production due to its ability to mediate the conversion of H2O2 to hydroxyl radicals via the Fenton reaction or by virtue of hypervalent iron compounds. It is shown here that iron facilitates A beta toxicity to cultured cells.
D000544:Alzheimer Disease / Q000503:physiopathology; D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D016923:Cell Death / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology / Q000187:drug effects / Q000473:pathology; D002999:Clone Cells; D003676:Deferoxamine / Q000494:pharmacology; D004357:Drug Synergism; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007501:Iron / Q000633:toxicity*; D007502:Iron Chelating Agents / Q000494:pharmacology; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000473:pathology; D009498:Neurotoxins / Q000633:toxicity*; D010446:Peptide Fragments / Q000633:toxicity
D016229:Amyloid beta-Peptides; D007502:Iron Chelating Agents; D009498:Neurotoxins; D010446:Peptide Fragments; C078592:amyloid beta-protein (1-40); C074636:amyloid beta-protein (25-35); D006861:Hydrogen Peroxide; D007501:Iron; D003676:Deferoxamine