Presumed acquired ocular toxoplasmosis.
OBJECTIVE
To describe the clinical characteristics and laboratory findings of eight patients with focal chorioretinitis presumably caused by acquired toxoplasmosis.


METHODS
Case series.


METHODS
Referral hospitals in the Netherlands.


METHODS
Eight patients, aged 42 to 75 years, with unilateral focal chorioretinitis and laboratory evidence of a recently acquired infection with Toxoplasma gondii.


METHODS
Findings from ocular examination and analysis of both serum and aqueous humor samples for Toxoplasma and viral antibodies.


RESULTS
All patients had unilateral focal chorioretinitis without associated old scars in the posterior pole. Patients treated with systemic or periocular corticosteroids not accompanied by antiparasitic medication showed a rapid increase of inflammation. All eight patients had Toxoplasma IgM antibodies in their serum samples, seven of whom had high Toxoplasma IgG titers. Five of eight patients had increased intraocular production of IgG antibodies against T gondii.


CONCLUSIONS
Unilateral focal chorioretinitis in patients of any age should alert the clinician to consider acquired ocular toxoplasmosis in the differential diagnosis.
D000328:Adult; D000368:Aged; D000818:Animals; D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000913:Antibodies, Protozoan / Q000032:analysis; D001082:Aqueous Humor / Q000276:immunology / Q000469:parasitology; D002825:Chorioretinitis / Q000175:diagnosis* / Q000188:drug therapy / Q000469:parasitology; D003937:Diagnosis, Differential; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005451:Fluorescein Angiography; D005654:Fundus Oculi; D006801:Humans; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D008297:Male; D008875:Middle Aged; D013256:Steroids; D014122:Toxoplasma / Q000276:immunology; D014126:Toxoplasmosis, Ocular / Q000175:diagnosis* / Q000188:drug therapy
D000893:Anti-Inflammatory Agents; D000913:Antibodies, Protozoan; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D013256:Steroids