title: [Recent multicenter study protocols in the USA for patients with metastatic prostatic carcinoma].
abstract: Combined androgen blockade for metastatic prostate cancer has become the standard against which on-going clinical trials are measured. Benefit of combined androgen blockade with an LHRH agonist (leuprolide) and an antiandrogen (flutamide) has been noted, particularly for those with minimal disease. This has led to timely accrual of patients to a trial testing whether orchidectomy with flutamide is superior to orchidectomy alone. Positive findings with permanent and intermittent withdrawal of flutamide has prompted the design and implementation of additional trials. Suramin has been reintroduced in trials of chemohormonal intervention. Past success with combined androgen blockade in lengthening survival and improving quality of life for patients with metastatic prostate cancer has prompted enthusiasm for broadening the base of clinical studies for this disease.
mesh_terms: D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage* / Q000009:adverse effects; D003131:Combined Modality Therapy; D005485:Flutamide / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage / Q000009:adverse effects; D008297:Male; D015337:Multicenter Studies as Topic; D009367:Neoplasm Staging; D009376:Neoplasms, Hormone-Dependent / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic; D013498:Suramin / Q000008:administration & dosage / Q000009:adverse effects; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D018931:Antineoplastic Agents, Hormonal; D013498:Suramin; D005485:Flutamide; D016729:Leuprolide
vernacular_title: Neuere Multicenterstudienprotokolle in den USA für Patienten mit einem metastasierten Prostatakarzinom.