Distribution of HLA antigens in Sadhu Chetty of Tamil Nadu, south India.
Blood samples from 101 individuals of Sadhu Chetty community domiciled in and around Madras (capital City of Tamil Nadu State, South India) were examined for HLA-A, B, C, DR and DQ antigen profiles. Phenotype, gene and haplotype frequencies were calculated and compared with the literature. Increased frequencies of HLA-B16 antigen and of the haplotype A2, B16 were characteristic. This study indicates the distinctiveness of the Sadhu Chetty population and highlights the importance of determining HLA frequencies in endogamous groups of India.
D003241:Consanguinity; D003906:Developing Countries; D005787:Gene Frequency / Q000235:genetics*; D005828:Genetics, Population; D006680:HLA Antigens / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D007194:India
D006680:HLA Antigens