Accumulation of lauric acid in skin as an enhancer for the percutaneous absorption of thiamine disulfide.
The permeation and accumulation of lauric acid (12:0) in rat skin as an enhancer for the percutaneous absorption of thiamine disulfide (TDS), using propylene glycol as a vehicle, were determined in vitro. 12:0 barely permeated through skin, and accumulated in skin. The accumulated amount increased increasing concentrations in the vehicle (1-20%). The proportion of the accumulation to total dose was highest at a dose of 5%. A positive relationship was found between the accumulated amount of TDS and 12:0. It was suggested that the penetration of 12:0 into skin contributes to the enhanced partition of TDS to skin.
D000818:Animals; D007850:Lauric Acids / Q000493:pharmacokinetics* / Q000494:pharmacology; D008297:Male; D011409:Propylene Glycols / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption / Q000187:drug effects*; D013268:Stimulation, Chemical; D013831:Thiamine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D007850:Lauric Acids; D011409:Propylene Glycols; C030358:lauric acid; C013293:thiamine disulfide; D013831:Thiamine