title: Collagen metabolism and tooth eruption: the effects of sodium morrhuate infusions on premolar eruption in dogs.
abstract: To test the essential contribution to tooth eruption of the known high level of collagen metabolism in the periodontal ligament, we have infused the crypts of erupting premolars in dogs with sodium morrhuate, a compound known to reduce production, hydroxyproline content and maturation of collagen. Infusions of sodium morrhuate early or later in eruption for more than half the period of eruption had no effect on the process evaluated radiographically and clinically. These data, considered together with other studies, suggest that collagen metabolism per se plays no essential role in tooth eruption.
mesh_terms: D000818:Animals; D001641:Bicuspid / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000502:physiology; D003094:Collagen / Q000037:antagonists & inhibitors* / Q000187:drug effects / Q000378:metabolism; D003864:Depression, Chemical; D004285:Dogs; D008334:Mandible; D011859:Radiography; D012976:Sodium Morrhuate / Q000494:pharmacology*; D013997:Time Factors; D014078:Tooth Eruption / Q000187:drug effects* / Q000502:physiology
chemical_list: D012976:Sodium Morrhuate; D003094:Collagen