title: [Effect of variations in middle ear pressure on ruptures of the round window membrane of the inner ear of the guinea pig (Cavia porcellus)].
abstract: The electrical activity of the inner ear before and after rupture of the round window membrane was monitored in guinea pigs under different pressure conditions with the aid of electrocochleography. Following studies were conducted weekly over a period of 4 weeks. Findings showed that overpressure below the pressure needed to open the Eustachian tube caused strong temporary functional disturbance of the cochlea, especially at high frequencies. Irreversible changes that were pressure-dependent were observed and occurred mainly at high frequencies. Application of low pressure to the round window membrane caused a functional loss comparable to changes after overpressure. Animals with a predamaged cochlea reacted to overpressure that was below opening pressure of the tube and to corresponding low pressure with a longer lasting functional loss than did animals with an undamaged cochlea.
mesh_terms: D000158:Acoustic Impedance Tests; D000161:Acoustic Stimulation; D000818:Animals; D001274:Atmospheric Pressure; D001300:Audiometry, Evoked Response; D001309:Auditory Threshold / Q000502:physiology; D005064:Eustachian Tube / Q000503:physiopathology; D006168:Guinea Pigs; D006319:Hearing Loss, Sensorineural / Q000503:physiopathology*; D008297:Male; D009925:Organ of Corti / Q000503:physiopathology*; D012016:Reference Values; D012405:Round Window, Ear / Q000503:physiopathology*; D012422:Rupture, Spontaneous
vernacular_title: Untersuchungen zum Einfluss von Mittelohrdruckschwankungen bei Rupturen der runden Fenstermembran auf das Innenohr des Meerschweinchens (Cavia porcellus).