title: Seasonal variation in plasma L-tryptophan availability in healthy volunteers. Relationships to violent suicide occurrence.
abstract: OBJECTIVE
  To investigate the seasonal variation in levels of plasma L-tryptophan and competing amino acids (CAAs) in healthy humans in relation to climatic variables, total serum protein levels, and violent suicide occurrence.
  
  
  METHODS
  Twenty-six healthy volunteers (13 men and 13 women; mean [+/- SD] age, 38.7 +/- 13.4 years) had monthly blood samplings for assays of L-tryptophan, valine, leucine, isoleucine, tyrosine, and phenylalanine during 1 calendar year.
  
  
  RESULTS
  Significant annual rhythms were detected in L-tryptophan, the L-tryptophan/CAA ratio, phenylalanine, valine, and leucine, and semiannual rhythms in L-tryptophan values and in L-tryptophan/CAA ratios. Plasma L-tryptophan and the L-tryptophan/CAA ratio were significantly lower in the spring than in the other seasons. The peak-trough differences in the yearly variation expressed as a percentage of the mean were 17.1% and 16.1% for L-tryptophan values and L-tryptophan/CAA ratios, respectively. The amplitude of the yearly variation in all CAAs was low, ie, less than 7%. An important part of the variance in L-tryptophan availability (ie, 12% to 14%) could be explained by the composite effects of present and past climatic factors; higher ambient temperature and relative humidity in the face of lower air pressure are the most important predictors of low L-tryptophan availability. Important and positive time relationships were noted between total serum protein level and all amino acid concentrations, and a significant time relationship was also noted between the seasonal variation in L-tryptophan availability and the occurrence of violent suicide in Belgium.
  
  
  CONCLUSIONS
  Our results show a bimodal seasonal pattern in the availability of plasma L-tryptophan that matches seasonal patterns in the prevalence of violent suicide in the local population and depression in other studies.
mesh_terms: D000328:Adult; D000596:Amino Acids / Q000097:blood; D001798:Blood Proteins / Q000032:analysis; D001921:Brain / Q000378:metabolism; D002940:Circadian Rhythm; D003866:Depressive Disorder / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D015995:Prevalence; D012044:Regression Analysis; D012621:Seasons; D013405:Suicide / Q000706:statistics & numerical data*; D014364:Tryptophan / Q000097:blood* / Q000378:metabolism; D014754:Violence; D014887:Weather
chemical_list: D000596:Amino Acids; D001798:Blood Proteins; D014364:Tryptophan