title: [A new and simple method of evaluating left ventricular contractility and its application].
abstract: After making theoretical analysis, we detected the relationship among the maximal tension of ventricular contraction, left ventricular end-systolic pressure and stroke volume, and then derived a new and simple method of evaluating left ventricular contractility, the slope of the left ventricular end-systolic pressure-volume relation (Emax). Twelve mongrel male dogs were used to test this method. The results show that the value of Emax (0.60 +/- 0.16 kPa/ml) coming from this simple method is very close to that from complicated method; this method has good repetitiveness and is very sensitive to the variation of myocardial contraction. Using the method for evaluating left ventricular contraction after ischemia, we found the Emax more cogent than other hemodynamic parameters. Therefore, this method is an efficient method of evaluating left ventricular contraction.
mesh_terms: D000818:Animals; D002316:Cardiotonic Agents / Q000494:pharmacology; D004285:Dogs; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia / Q000503:physiopathology; D013318:Stroke Volume; D016277:Ventricular Function, Left; D017725:Ventricular Pressure
chemical_list: D002316:Cardiotonic Agents; D007545:Isoproterenol