[Biological surveillance of hormone substitution: relying on the plasma levels of estradiol or the products used?].
The success of hormone substitution in menopaused women is widely recognized. Generally an oestrogen or a progesterone is used. The aim of this work was to determine whether the oestrogen treatment can be monitored on the basis of the induced plasma levels of oestradiol and whether there is any difference between specific products available. A review of the literature and personal observations concerning the pharmacokinetics of different oestrogen therapies has shown that the single assay of oestradiol is insufficient to adapt dosages and that different products are dosed differently giving variable reproductibility between the different formulations available.
D000328:Adult; D000368:Aged; D015982:Bias; D016903:Drug Monitoring / Q000379:methods*; D004958:Estradiol / Q000097:blood*; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000008:administration & dosage / Q000097:blood* / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008875:Middle Aged; D012016:Reference Values; D015203:Reproducibility of Results
D004967:Estrogens; D004958:Estradiol
Surveillance biologique du traitement hormonal substitutif: se fier aux dosages plasmatiques d'estradiol ou aux produits utilisés?