Spindle-cell hemangioendothelioma of the oral cavity. A case report.
We describe a vascular tumor classified as SCH by histological criteria that was found in the mandibular-buccal fold of a 12-year-old girl. Microscopically, the lesion consisted of thin-walled cavernous spaces containing thrombi and phleboliths, and cellular areas composed of spindle-shaped, epithelioid and vacuolated cells. Immunohistochemically, the endothelial vascular lining was highly reactive with HAM56 antibody, while variable reactivity was observed for factor VIII-associated antigen. All cell types were positive for vimentin and anti-PCNA stained less than 3% of the tumor cells. This is the first report of SCH in the oral cavity.
D000906:Antibodies / Q000032:analysis; D000911:Antibodies, Monoclonal; D002610:Cheek / Q000473:pathology; D002648:Child; D003029:Coagulants / Q000032:analysis; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D006390:Hemangioendothelioma / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D009061:Mouth Mucosa / Q000473:pathology; D009062:Mouth Neoplasms / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D013927:Thrombosis / Q000473:pathology; D014746:Vimentin / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis
D000906:Antibodies; D000911:Antibodies, Monoclonal; D003029:Coagulants; C096893:HAM-56 antibody; D018809:Proliferating Cell Nuclear Antigen; D014746:Vimentin; D014841:von Willebrand Factor