[The effect of inhibitors of DNA and protein synthesis on the yield of chromosome aberrations in a human lymphocyte culture under gamma and neutron irradiation at different stages of the mitotic cycle. The cytogenetic effects at the G1 stage].
The impact of DNA of protein synthesis inhibitors (cycloheximide or hydroxyurea with 5-fluorodeoxyuridine -HU + FUrd, respectively) on the yield of chromosome aberration induced with gamma rays (1 or 2 Gy) and neutrons (0.5 or 1 Gy) at G1-stage of mitotic cycle was studied in human lymphocytes. The both inhibitors were discovered to increase the effect of gamma radiation at nearly all periods after irradiation during 5 hours. Conversely, the decrease in the level of chromosome aberrations was observed for neutrons after action of inhibitors at the same periods.
D001798:Blood Proteins / Q000037:antagonists & inhibitors*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D003513:Cycloheximide / Q000494:pharmacology; D004247:DNA / Q000037:antagonists & inhibitors*; D005467:Floxuridine / Q000494:pharmacology; D016193:G1 Phase / Q000187:drug effects* / Q000528:radiation effects*; D005720:Gamma Rays; D006801:Humans; D006918:Hydroxyurea / Q000494:pharmacology; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects* / Q000648:ultrastructure; D008677:Metaphase / Q000187:drug effects / Q000528:radiation effects; D008938:Mitosis / Q000187:drug effects / Q000528:radiation effects; D009502:Neutrons; D011500:Protein Synthesis Inhibitors / Q000494:pharmacology; D013997:Time Factors
D001798:Blood Proteins; D011500:Protein Synthesis Inhibitors; D005467:Floxuridine; D004247:DNA; D003513:Cycloheximide; D006918:Hydroxyurea
Vliianie ingibitorov sinteza DNK i belka na vykhod aberratsiĭ khromosom v kul'ture limfotsov cheloveka pri gamma- i neĭtronnom obluchenii v razlichnykh stadiiakh mitoticheskogo tsikla. Tsitogeneticheskie éffekty v stadii G1.