Skeletal muscle ultrastructural and biochemical alterations induced by experimental hyperthyroidism.
Rats treated with high doses of T4 showed an increase in the oxygen consumption in state 3 rate respiration of mitochondria isolated from Soleus (slow twitch) and Extensor Digitorum Longus (EDL, fast twitch) muscles, without modification of either their phosphorylation efficiency (ADP/O ratio) or their coupling. Muscle fiber main alterations were atrophy and changes of the structure and shape of mitochondria. Also, abundant autophagic vacuoles with mitochondrial debris, myelin-like figures, glycogenosomes and primary lysosomes were found.
D000818:Animals; D006980:Hyperthyroidism / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D008854:Microscopy, Electron; D008931:Mitochondria, Muscle / Q000737:chemistry / Q000648:ultrastructure; D018482:Muscle, Skeletal / Q000737:chemistry / Q000503:physiopathology / Q000648:ultrastructure*; D010101:Oxygen Consumption / Q000187:drug effects; D051381:Rats; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine
D013963:Thyroid Hormones; D013972:Thyrotropin; D013974:Thyroxine