[Effect of prednisolone on 3H-catecholamine synthesis in the adrenals of physically fatigued rats].
The effect of prednisolone on the synthesis of 3H-catecholamines by the adrenals of control and rats swimming for 8 hours was studied in experiments in vitro with the use of 3H-thyroxine as precursor. It was shown that in swimming rats, the synthesis of 3H-noradrenaline and 3H-adrenaline is inhibited by 25%, while the synthesis of 3H-dopamine remains unchanged. Addition of prednisolone to the incubation medium does not affect the rate of 3H-catecholamine synthesis by the adrenals of intact rats. Addition of prednisolone to the adrenals of swimming rats leads to the stimulation of the synthesis of 3H-noradrenaline and 3H-adrenaline by 72%, while the synthesis of 3H-dopamine gets stimulated by 56% relative to the synthesis rate of 3H-catecholamines during swimming. In the latter case the rate of 3H-catecholamine synthesis significantly exceeds the control level.
D000311:Adrenal Glands / Q000378:metabolism*; D000818:Animals; D002395:Catecholamines / Q000096:biosynthesis*; D004298:Dopamine / Q000096:biosynthesis; D004837:Epinephrine / Q000096:biosynthesis; D005221:Fatigue / Q000188:drug therapy* / Q000378:metabolism; D008297:Male; D009638:Norepinephrine / Q000096:biosynthesis; D011239:Prednisolone / Q000627:therapeutic use*; D051381:Rats
D002395:Catecholamines; D011239:Prednisolone; D004298:Dopamine; D009638:Norepinephrine; D004837:Epinephrine
Deĭstvie prednizolona na sintez 3H-katekholaminov v nadpochechnikakh krys pri fizicheskom utomlenii.