Cathepsin D--a main proteolytic enzyme of the bovine vitreous.
It was found that the bovine vitreous contains a proteolytic enzyme which demonstrates characteristic features of cathepsin D. It acts in acidic pH, actively digests denatured protein substrates and demonstrates a high susceptibility on the inhibitory action of pepstatin. It is localized in liquid part of the bovine vitreous. A role of this enzyme in physiology and pathology of the eye is discussed.
D000818:Animals; D002402:Cathepsin D / Q000037:antagonists & inhibitors / Q000378:metabolism*; D002417:Cattle; D006863:Hydrogen-Ion Concentration; D010436:Pepstatins / Q000494:pharmacology; D011480:Protease Inhibitors / Q000494:pharmacology; D013379:Substrate Specificity; D014822:Vitreous Body / Q000201:enzymology*
D010436:Pepstatins; D011480:Protease Inhibitors; C014195:Streptomyces pepsin inhibitor; D002402:Cathepsin D; C031375:pepstatin