Modification of lipogenesis in the isolated hamster flank organ through clofibric acid.
The hamster flank organ model was used to measure the effects of clofibric acid on the in vitro uptake of sodium [1-14C] acetate into lipids. Clofibric acid produces a dose-dependent inhibition of lipogenesis in the hamster flank organ in vitro.
D000085:Acetates / Q000378:metabolism; D000818:Animals; D002995:Clofibric Acid / Q000494:pharmacology*; D006224:Cricetinae; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D000431:Ethanol / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D066298:In Vitro Techniques; D008055:Lipids / Q000096:biosynthesis*; D008297:Male; D008647:Mesocricetus; D012627:Sebaceous Glands / Q000187:drug effects / Q000378:metabolism*
D000085:Acetates; D000960:Hypolipidemic Agents; D008055:Lipids; D000431:Ethanol; D002995:Clofibric Acid; D004121:Dimethyl Sulfoxide