Detrusor regeneration in the rat using porcine small intestinal submucosal grafts: functional innervation and receptor expression.
OBJECTIVE
To evaluate functional characteristics of regenerated bladder induced by small intestinal submucosa (SIS).


METHODS
Strips from bladder regenerated from SIS and normal rat bladder were evaluated by in vitro muscle bath contractility studies.


RESULTS
The present results indicate that SIS-regenerated bladder 1) demonstrates contractile activity; 2) expresses muscarinic, purinergic and beta adrenergic receptors; and 3) exhibits functional cholinergic and purinergic innervation that is similar to the normal rat urinary bladder muscle.


CONCLUSIONS
These functional characteristics of SIS-regenerated tissue demonstrated in the present study further support use of SIS material as a bladder augmentation material.
D000818:Animals; D005260:Female; D007413:Intestinal Mucosa / Q000637:transplantation*; D007583:Jejunum / Q000637:transplantation*; D009119:Muscle Contraction / Q000502:physiology; D009130:Muscle, Smooth / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011943:Receptors, Adrenergic, beta / Q000502:physiology; D011976:Receptors, Muscarinic / Q000502:physiology; D011983:Receptors, Purinergic / Q000502:physiology; D013552:Swine; D014183:Transplantation, Heterologous; D001743:Urinary Bladder / Q000294:innervation / Q000502:physiology / Q000601:surgery*
D011943:Receptors, Adrenergic, beta; D011976:Receptors, Muscarinic; D011983:Receptors, Purinergic