title: Potentiation of ionophorous anticoccidials with duokvin: battery trials against Cryptosporidium baileyi in chickens.
abstract: Three battery tests, employing 444 Arbor Acres chickens, were conducted to study the anticryptosporidial efficacy of the polyether ionophorous anticoccidials alone and in combination with a new dihydroquinoline antioxidant, duokvin. The following efficacy percentages for the ionophores at the recommended level were established on the basis of oocyst output: lasalocid 45, monensin 37, semduramicin 29, narasin 23, and maduramicin and salinomycin 21. The efficacy of the ionophores, with the exception of lasalocid, could be increased to 36-88% by combination with duokvin. However, these combinations resulted in a significant weight gain reduction due to toxic interaction. Efficacy showed a strong negative correlation with body weight gain and bursa weight, suggesting an indirect mode of action against the parasite. It has been concluded that neither ionophorous anticoccidials nor their combinations with duokvin can be recommended for chemoprophylaxis against avian cryptosporidiosis.
mesh_terms: D000818:Animals; D002060:Bursa of Fabricius; D002645:Chickens; D003049:Coccidiostats / Q000494:pharmacology / Q000627:therapeutic use*; D003457:Cryptosporidiosis / Q000188:drug therapy / Q000662:veterinary*; D004359:Drug Therapy, Combination; D007476:Ionophores / Q000494:pharmacology / Q000627:therapeutic use; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010270:Parasite Egg Count; D011201:Poultry Diseases / Q000188:drug therapy*; D011804:Quinolines / Q000494:pharmacology / Q000627:therapeutic use*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D003049:Coccidiostats; D007476:Ionophores; D011804:Quinolines; C089026:duokvin