Behavioral effects of the cyclic cholecystokinin peptide analogue JMV-320.
The in vivo effects of JMV-320 (a highly selective CCKB receptor ligand) and of CCK-4 on exploratory activity and memory in rats were compared. JMV-320 and CCK-4 did not modulate exploratory activity in an open field test but decreased it in an elevated plus-maze. CCK-4 (50 micrograms/kg) impaired passive avoidance response 3 h after training and JMV-320 (1 and 10 micrograms/kg) decreased active avoidance response 24 h after training. The behavioral effects of JMV-320 resemble the effects of CCK-4 and suggest that in vivo JMV-320 acts as a CCKB receptor agonist.
D000704:Analysis of Variance; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005106:Exploratory Behavior / Q000187:drug effects*; D006727:Hormone Antagonists / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects*; D008568:Memory / Q000187:drug effects*; D011678:Punishment; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000502:physiology; D012054:Reinforcement, Psychology; D012844:Sincalide / Q000031:analogs & derivatives* / Q000494:pharmacology; D013758:Tetragastrin / Q000494:pharmacology; D013997:Time Factors
D006727:Hormone Antagonists; D011949:Receptors, Cholecystokinin; D013758:Tetragastrin; C075380:JMV 320; D012844:Sincalide