Adrenomedullin and calcitonin gene-related peptide in the rat isolated kidney and in the anaesthetised rat: in vitro and in vivo effects.
The effects of adrenomedullin and calcitonin gene-related peptide (CGRP) were compared in the rat isolated perfused kidney and in the anaesthetised rat. Adrenomedullin and CGRP both elicited concentration-dependent vasodilator responses from perfused kidneys (adrenomedullin was less potent than CGRP). These responses were blocked by CGRP-(8-37) (1 microM). Adrenomedullin and CGRP elicited dose-dependent hypotension in anaesthetised rats (adrenomedullin was less potent than CGRP). The hypotensive responses to CGRP, but not those to adrenomedullin, were antagonized by CGRP-(8-37) (12 nmol/kg/min). These studies indicate that the in vivo response to adrenomedullin may be mediated through CGRP-(8-37) insensitive receptors.
D053607:Adrenomedullin; D000758:Anesthesia; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D004347:Drug Interactions; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000187:drug effects*; D008297:Male; D010446:Peptide Fragments / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D010477:Perfusion; D051381:Rats; D017207:Rats, Sprague-Dawley; D012079:Renal Circulation / Q000187:drug effects
D000959:Antihypertensive Agents; D010446:Peptide Fragments; D010455:Peptides; C058636:calcitonin gene-related peptide (8-37); D053607:Adrenomedullin; D015740:Calcitonin Gene-Related Peptide