Frequency of biochemical hypothyroidism in sera referred for autoantibody testing.
We examined sera submitted for autoantibody testing for thyroid microsome antibodies (TMA), elevated thyroid-stimulating hormone (TSH), and free thyroxine concentrations. The frequency of TMA in antinuclear antibody-positive sera was higher (19%) than that in antinuclear antibody-negative sera (12%). Elevated TSH concentrations in serum and subnormal thyroxine concentrations in serum were associated with the presence of TMA; TMA titer and the frequency of elevated TSH concentrations were also associated with the presence of TMA.
D000328:Adult; D000974:Antibodies, Antinuclear / Q000097:blood*; D001323:Autoantibodies / Q000097:blood*; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000276:immunology*; D008861:Microsomes / Q000276:immunology*; D013961:Thyroid Gland / Q000276:immunology*; D013972:Thyrotropin / Q000097:blood
D000974:Antibodies, Antinuclear; D001323:Autoantibodies; C056626:thyroid microsomal antibodies; D013972:Thyrotropin