title: Cyclin I: a new cyclin encoded by a gene isolated from human brain.
abstract: A new member of the cyclin family has been isolated from an equalized cDNA library derived from human forebrain cortex. This putative cyclin, designated cyclin I, contains a typical cyclin box near the N-terminus and a PEST sequence near the C-terminus. Cyclin I shows the highest sequence similarity in the cyclin box to cyclins G and E, while the similarity between cyclins I and G also extends toward the C-terminus from the cyclin box. Cyclin I mRNA was expressed at high levels in postmitotic tissues, including skeletal muscle, heart, and brain, and was expressed constantly during cell cycle progression. The expression of cyclin I mRNA does not correlate directly to the cell cycle, and therefore cyclin I may be a novel cyclin member that functions independently of the cell cycle control.
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002453:Cell Cycle; D002460:Cell Line; D002540:Cerebral Cortex / Q000737:chemistry*; D003001:Cloning, Molecular; D056749:Cyclin I; D016213:Cyclins / Q000737:chemistry / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics; D005347:Fibroblasts; D015870:Gene Expression; D005796:Genes / Q000235:genetics*; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D009928:Organ Specificity; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid
chemical_list: C534756:CCNI protein, human; D056749:Cyclin I; D016213:Cyclins; D018076:DNA, Complementary; D012333:RNA, Messenger