Antimitotic and antiviral activities of Kelletinin A in HTLV-1 infected MT2 cells.
Kelletinin A [ribityl-pentakis (p-hydroxybenzoate)] (KA), a natural compound isolated from the marine gastropod Buccinulum corneum, showed antiviral activity on the human T-cell leukemia virus type-1 (HTLV-1) and antimitotic activity on HTLV-1-infected MT2 cells. KA inhibited cellular DNA and RNA synthesis, without influencing protein synthesis, and interfered with viral transcription by reducing the levels of high molecular weight transcripts. Finally, the compound inhibited HTLV-1 reverse transcriptase in vitro.
D000970:Antineoplastic Agents / Q000494:pharmacology*; D000998:Antiviral Agents / Q000494:pharmacology*; D015152:Blotting, Northern; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D004261:DNA Replication / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D015368:Human T-lymphotropic virus 1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D062385:Hydroxybenzoates / Q000494:pharmacology* / Q000633:toxicity; D014176:Protein Biosynthesis; D012313:RNA / Q000037:antagonists & inhibitors / Q000096:biosynthesis; D012367:RNA, Viral / Q000032:analysis / Q000096:biosynthesis; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012255:Ribitol / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000633:toxicity; D013601:T-Lymphocytes; D014779:Virus Replication / Q000187:drug effects*
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D062385:Hydroxybenzoates; D012367:RNA, Viral; C067618:kelletinin A; D012255:Ribitol; D012313:RNA; D012194:RNA-Directed DNA Polymerase