Plasma atrial natriuretic peptide during spontaneous bronchoconstriction in asthmatics.
The aim of this work was to establish the role of endogeneous ANP during a spontaneous asthma attack. Forced expiratory lung volume in 1 s (FEV1), cardiovascular parameters, and plasma ANP, cAMP, and cGMP were measured for 60 min before and 10 min after treatment with a bronchodilator in 10 asthmatics. The results show that in the presence of moderate bronchoconstriction, FEV1 was 54 +/- 3% (+/-SE); ANP levels initially were slightly elevated at 47 +/- 10 pg/ml and decreased to 26 +/- 3 pg/ml (p < 0.05) over 60 min, with no change in FEV1. Following salbutamol inhalation, FEV1 increased to 77 +/- 4% with no change in ANP. We conclude that endogenous ANP does not act as a bronchodilator in asthmatics with moderate bronchospasm.
D000208:Acute Disease; D000328:Adult; D000420:Albuterol / Q000627:therapeutic use*; D000704:Analysis of Variance; D001249:Asthma / Q000097:blood* / Q000188:drug therapy / Q000503:physiopathology; D009320:Atrial Natriuretic Factor / Q000097:blood* / Q000502:physiology; D001980:Bronchi / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008297:Male
D009320:Atrial Natriuretic Factor; D000420:Albuterol