title: [The consequences for the first-generation progeny of Wistar rats of the irradiation of both parents with a background of mexamine use].
abstract: In experiments with Wistar rats it was shown that the efficiency of mexamine as radioprotector was substantially lower when sex cells of both parents (spermatozoids, spermatids, ovocytes) were irradiated with a dose of 2-4 Gy than after irradiation one parent only. It may be associated with the aggravation of effects in the posterity being conceived from gametes of both exposed parents.
mesh_terms: D008735:5-Methoxytryptamine / Q000494:pharmacology*; D000818:Animals; D004307:Dose-Response Relationship, Radiation; D005220:Fathers; D005260:Female; D005718:Gametogenesis / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D008098:Litter Size / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D051381:Rats; D017208:Rats, Wistar; D014916:Whole-Body Irradiation
chemical_list: D008735:5-Methoxytryptamine
vernacular_title: Posledstviia dlia potomstva pervogo pokoleniia krys linii Vistar oblucheniia oboikh roditeleĭ na fone primeneniia meksamina.