Histopathology of C57BL/6 mice inoculated orally with Mycobacterium paratuberculosis.
The susceptibility of C57BL/6 mice to oral inoculation with Myobacterium paratuberculosis was evaluated histopathologically. Granulomatous lesions containing acid-fast bacteria developed in the mesenteric lymph nodes in over 50% of the mice by 11 months after inoculation. The results suggest that C57BL/6 mice may be useful for studying infection, pathogenesis, and other aspects of paratuberculosis.
D000284:Administration, Oral; D000818:Animals; D008198:Lymph Nodes / Q000382:microbiology / Q000473:pathology; D008643:Mesentery; D051379:Mice; D008810:Mice, Inbred C57BL; D016927:Mycobacterium avium subsp. paratuberculosis / Q000302:isolation & purification*; D010283:Paratuberculosis / Q000473:pathology* / Q000635:transmission; D010581:Peyer's Patches / Q000382:microbiology / Q000473:pathology