Biocatalytic oxidation of polycyclic aromatic hydrocarbons by hemoglobin and hydrogen peroxide.
Hemoglobin is able to oxidize polycyclic aromatic hydrocarbons, PAH's, in presence of hydrogen peroxide. Among 12 aromatic compounds tested, six were oxidized; anthracene, carbazole, dibenzothiophene, fluorene, 9-hexylanthracene and pyrene. The products were identified as aromatic ketones and sulfoxides. Effect of organic solvent concentration and hemoglobin stability were determined.
D000097:Acetonitriles; D002384:Catalysis; D002849:Chromatography, Gas; D004355:Drug Stability; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D006861:Hydrogen Peroxide; D007700:Kinetics; D010084:Oxidation-Reduction; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000378:metabolism*; D012997:Solvents; D013329:Structure-Activity Relationship
D000097:Acetonitriles; D006454:Hemoglobins; D011083:Polycyclic Compounds; D012997:Solvents; D006861:Hydrogen Peroxide; C032159:acetonitrile