Further observations on MxA-positive Lewy bodies in Parkinson's disease brain tissues.
MxA protein, one of the GTPases, is induced in the cytoplasm by interferons and confers a high degree of resistance to some viruses. We recently reported that in cases of Parkinson's disease (PD), Lewy bodies (LBs) in the substantia nigra (SN) were positive for MxA. This study aimed to provide more detailed data on MxA-positive structures in the SN in PD brain tissues. Swellings of neuronal processes, as well as LBs, were positive for MxA. Immuno-electron microscopy revealed that reaction products corresponding to MxA proteins localized in self-aggregations similar to those reported for Mx1 protein in mouse tissues. These results show that MxA may play a role in the formation of LBs and swellings of neuronal processes.
D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000473:pathology* / Q000648:ultrastructure; D001923:Brain Chemistry / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D016631:Lewy Bodies / Q000378:metabolism*; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D064547:Myxovirus Resistance Proteins; D010300:Parkinson Disease / Q000378:metabolism* / Q000473:pathology; D011506:Proteins / Q000378:metabolism*; D013378:Substantia Nigra / Q000473:pathology / Q000648:ultrastructure; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
C579071:MX1 protein, human; C579070:Mx1 protein, mouse; D064547:Myxovirus Resistance Proteins; D011506:Proteins; D014446:Tyrosine 3-Monooxygenase; D019204:GTP-Binding Proteins