Autoimmune hepatitis following hepatitis A virus infection.
A 7-year-old patient is reported who suffered from fatigue and jaundice due to chronic hepatitis. He had acquired hepatitis A virus infection in his community and communicated the disease to his German family 4 weeks later. While the other family members recovered from acute viral hepatitis A, the patient presented 10 weeks after the onset of hyperbilirubinemia (12 mg/dl) with the histology of chronic hepatitis, absence of markers for viral persistence, presence of autoantibodies against smooth muscle (1:320) and the asialoglycoprotein receptor (1:600), and marked hypergammaglobulinemia (3700 mg/dl), leading to the diagnosis of autoimmune hepatitis. The patient received immunosuppressive therapy, symptoms of liver disease disappeared, and autoantibodies cleared from circulation. The case is discussed in the context of a putative virus-induced autoimmune hepatitis in childhood. Autoimmune hepatitis may be induced by an external trigger. Hepatitis A virus infection is one of probably several triggers that may induce autoimmune hepatitis in predisposed individuals.
D037263:Asialoglycoprotein Receptor; D001212:Asialoglycoproteins / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000209:etiology*; D002648:Child; D002908:Chronic Disease; D004198:Disease Susceptibility; D006505:Hepatitis / Q000209:etiology*; D006506:Hepatitis A / Q000150:complications*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000209:etiology / Q000276:immunology; D008297:Male; D009130:Muscle, Smooth / Q000276:immunology; D011956:Receptors, Cell Surface / Q000276:immunology
D037263:Asialoglycoprotein Receptor; D001212:Asialoglycoproteins; D001323:Autoantibodies; D011956:Receptors, Cell Surface