[The HLA-associated immunological mechanisms in rheumatic involvement of the myocardium].
The examination of 95 Uzbeks with rheumatic myocardium and 60 healthy subjects of the same nationality has found accumulation in the patients' phenotypes of antigens HLA-B17, HLA-B21 and HLA-Cw4. A high PHA-induced response of T-lymphocytes occurred in HLA-Cw4- and especially in HLA-B21-positive patients. The findings suggest participation of HLA-associated genes in the mechanisms of rheumatic process. These are thought responsible for rheumatism-specific cell immune reactions.
D000293:Adolescent; D000328:Adult; D006680:HLA Antigens / Q000097:blood* / Q000235:genetics; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D008875:Middle Aged; D010641:Phenotype; D012214:Rheumatic Heart Disease / Q000208:ethnology / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D014610:Uzbekistan
D006680:HLA Antigens
HLA-assotsiirovannye immunologicheskie mekhanizmy pri revmaticheskom porazhenii miokarda.