[Local cutaneous necrosis after injection of interferon beta].
BACKGROUND
Skin necrosis at the site of interferon injections is unusual. With beta-interferon, it has been observed with high doses ranging from 90 to 180 millions daily.


METHODS
Is reported a case of abdominal skin necrosis following 6 months treatment with beta-interferon injections, 9 millions 3 times a week, in a 56 years-old man with chronic type C hepatitis. Histological analysis showed fibrin thrombosis of deep dermal vessels. There was no coagulation abnormality.


CONCLUSIONS
The mechanisms of the interferon induced skin necrosis are discussed.
D000009:Abdominal Muscles; D000998:Antiviral Agents / Q000008:administration & dosage / Q000009:adverse effects; D006526:Hepatitis C / Q000188:drug therapy; D006521:Hepatitis, Chronic / Q000188:drug therapy; D006801:Humans; D007279:Injections, Subcutaneous; D016899:Interferon-beta / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000139:chemically induced*; D012871:Skin Diseases / Q000139:chemically induced* / Q000473:pathology
D000998:Antiviral Agents; D016899:Interferon-beta
Nécrose cutanée locale après injections d'interféron bêta.