Increased muscle sympathetic nerve activity after glucagon administration in man.
Muscle sympathetic nerve activity (MSNA) after glucagon administration was quantitatively measured in five healthy male volunteers (age: 20-28 years old). After an overnight fasting, 1 mg glucagon dissolved in a 1-ml vehicle was injected i.v. as a bolus. MSNA, ECG and blood pressure were simultaneously recorded 15 min before and after the injection. MSNA (bursts/min), heart rate (HR), and systolic and diastolic blood pressures (dBP and sBP) were significantly increased at 2-3 min after glucagon injection. Their means and standard deviations of control for 15 min vs. 3 min after the injection were in the five subjects; MSNA, 10 +/- 6 vs. 30 +/- 10 bursts/min, HR, 61 +/- 10 vs. 76 +/- 8 beats/min, dBP, 66 +/- 9 vs. 91 +/- 9 mmHg and sBP, 122 +/- 12 vs. 152 +/- 11 mmHg. These results suggest that glucagon has a direct facilitatory effect on the central sympathetic nervous system.
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D005934:Glucagon / Q000494:pharmacology*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000294:innervation*; D013564:Sympathetic Nervous System / Q000187:drug effects*
D001786:Blood Glucose; D007328:Insulin; D005934:Glucagon