title: Effect of chloro-, cyano-, and amidino-substituted flavanoids on enterovirus infection in vitro.
abstract: Synthetic flavans, isoflavans and isoflavenes substituted with chloro, cyano and amidino groups were tested for their in vitro activity against poliovirus type 2, Coxsackie virus B4, echovirus type 6 and enterovirus 71. Plaque-reduction assays showed that substituted 3-(2H)-isoflavenes, carrying a double bond in the oxygenated ring, possess antiviral activity higher than that of the corresponding isoflavans. The most effective compounds were 4'-chloro-6-cyanoflavan and 6-chloro-4'-cyanoflavan. Studies on the mechanism of action of these two compounds suggested an effect on the early stages of viral replication.
mesh_terms: D000578:Amidines / Q000737:chemistry; D002712:Chlorides / Q000737:chemistry; D003486:Cyanides / Q000737:chemistry; D004770:Enterovirus / Q000187:drug effects* / Q000378:metabolism; D005419:Flavonoids / Q000737:chemistry / Q000494:pharmacology* / Q000633:toxicity; D006358:Hot Temperature; D006801:Humans; D014176:Protein Biosynthesis / Q000187:drug effects; D012367:RNA, Viral / Q000096:biosynthesis / Q000187:drug effects; D014407:Tumor Cells, Cultured; D014764:Viral Proteins / Q000096:biosynthesis / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
chemical_list: D000578:Amidines; D002712:Chlorides; D003486:Cyanides; D005419:Flavonoids; D012367:RNA, Viral; D014764:Viral Proteins