Effect of administration of serum thymic factor (FTS) in calves and rabbits infected with bovine immunodeficiency-like virus.
The effect of serum thymic factor (FTS) administration in bovine immunodeficiency-like virus (BIV)-infected calves and rabbits was examined. We previously found that some of the macrophage functions were depressed and humoral immune responses against foreign proteins were delayed in BIV-infected calves compared to uninfected calves. After FTS administration, however, no delay of antibody responses against foreign proteins was observed in BIV-infected calves. Though the chemiluminescence (CL) responses of macrophages in BIV-infected calves were significantly depressed (p < 0.05), FTS administration resulted in the recovery of the CL responses in the BIV-infected calves comparable to those in the control calves. Antibody responses against foreign proteins in BIV-infected rabbits were significantly depressed (p < 0.025) as compared with those in uninfected rabbits, though the depression became no significant after FTS administration.
D000818:Animals; D000917:Antibody Formation; D001798:Blood Proteins / Q000276:immunology; D002417:Cattle; D004912:Erythrocytes / Q000276:immunology; D016087:Immunodeficiency Virus, Bovine; D016180:Lentivirus Infections / Q000276:immunology* / Q000628:therapy; D008163:Luminescent Measurements; D008264:Macrophages / Q000276:immunology*; D051379:Mice; D011817:Rabbits; D012756:Sheep; D013935:Thymic Factor, Circulating / Q000494:pharmacology*; D013997:Time Factors
D001798:Blood Proteins; D013935:Thymic Factor, Circulating