The influence of different fluoride salts on fluoride-mediated inhibition of peroxidase activity in human saliva.
Fluoride-mediated inhibition of peroxidase potential activity in human saliva was investigated using NaF, NH4F, CaF2, Na2PO3F (MFP), SnF2 and TiF4. At pH 5.5 and for a 20 mM F concentration, the inhibition percentages increased from 2% for MFP and 5% for CaF2 to 61% for NaF and 65% for NH4F, while a 100% inhibition was observed at 10 mM for TiF4 and at 5 mM for SnF2. The inhibition was enhanced at acid pH and removed at pH 7. The inhibition could be attributed to ionized F-, except for SnF2 and TiF4, in which part of the inhibition could be imputed to the cations.
D002124:Calcium Fluoride / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005459:Fluorides / Q000494:pharmacology*; D005460:Fluorides, Topical / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009195:Peroxidase / Q000037:antagonists & inhibitors*; D010710:Phosphates / Q000494:pharmacology; D012463:Saliva / Q000201:enzymology*; D012471:Salivary Proteins and Peptides / Q000037:antagonists & inhibitors*; D012969:Sodium Fluoride / Q000494:pharmacology; D014002:Tin Fluorides / Q000494:pharmacology
D004791:Enzyme Inhibitors; D005460:Fluorides, Topical; D010710:Phosphates; D012471:Salivary Proteins and Peptides; D014002:Tin Fluorides; C094808:amine fluoride solution; C012980:fluorophosphate; D012969:Sodium Fluoride; D009195:Peroxidase; D002124:Calcium Fluoride; D005459:Fluorides