Role of hemolysis in neonatal jaundice associated with glucose-6 phosphate dehydrogenase deficiency.
End-tidal carbon monoxide was measured in 108 newborn infants who had been screened for glucose-6-phosphate dehydrogenase (G6PD) deficiency. The mean +/- SD end-tidal carbon monoxide did not differ significantly between the G6PD-deficient and the normal neonates, 2.1 +/- 0.6 microliters/L and 2.0 +/- 0.5 microliters/L, respectively, within 12 hours of birth and 1.9 +/- 1.4 microliters/L and 1.5 +/- 0.7 microliters/L, respectively, at 48 to 72 hours after birth. On the basis of these measurements, hemolysis is not a sufficient explanation for jaundice in G6PD-deficient newborn infants in the transitional period.
D001663:Bilirubin / Q000097:blood; D001944:Breath Tests; D002248:Carbon Monoxide / Q000032:analysis; D016009:Chi-Square Distribution; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000097:blood*; D006461:Hemolysis; D006801:Humans; D007231:Infant, Newborn; D007567:Jaundice, Neonatal / Q000097:blood*; D011446:Prospective Studies
D002248:Carbon Monoxide; D005954:Glucosephosphate Dehydrogenase; D001663:Bilirubin