title: Enriched HLA-DQ3 phenotype and decreased class I major histocompatibility complex antigen expression in recurrent respiratory papillomatosis.
abstract: Respiratory papillomas, caused by human papillomaviruses, are benign tumors that recur following removal. We evaluated immune function and major histocompatibility complex (MHC) phenotype and expression in these patients. MHC-independent immune function appeared normal. The frequency of peripheral blood MHC class II phenotypes was highly enriched for DQ3 and DR11, one split of DR5. Class I MHC antigen expression on papilloma tissue was markedly reduced. Together, these phenomena may facilitate papillomavirus evasion of the cellular immune response.
mesh_terms: D000328:Adult; D002648:Child; D002675:Child, Preschool; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D006683:HLA-DQ Antigens / Q000032:analysis*; D015395:Histocompatibility Antigens Class I / Q000032:analysis*; D006801:Humans; D016130:Immunophenotyping; D008297:Male; D009364:Neoplasm Recurrence, Local; D010212:Papilloma / Q000276:immunology*; D012142:Respiratory Tract Neoplasms / Q000276:immunology*; D012189:Retrospective Studies
chemical_list: D006683:HLA-DQ Antigens; C051569:HLA-DQ3 antigen; D015395:Histocompatibility Antigens Class I