Effect of feeding clofibrate-containing diet on the hepatic NAD+ level in rats.
Feeding rats with a diet containing 0.25% clofibrate for 2 weeks elevated the hepatic NAD+ and total nicotinate levels significantly. Other peroxisome proliferators, such as 2-(4-chlorophenoxy)propionic acid and di(2-ethylhexyl)phthalate, had similar effects. When rats were fed the control diet without clofibrate for 1 week after 2 weeks of the clofibrate diet, the hepatic NAD+ level returned to the control value. Muscular NAD+ content was not affected by the peroxisome proliferators. The results were discussed in relation to induction of peroxisomal beta-oxidation enzymes by the peroxisome proliferators.
D000818:Animals; D002994:Clofibrate / Q000008:administration & dosage* / Q000494:pharmacology; D004032:Diet; D004051:Diethylhexyl Phthalate / Q000008:administration & dosage / Q000494:pharmacology; D011345:Fenofibrate / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000008:administration & dosage* / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000378:metabolism* / Q000648:ultrastructure; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000378:metabolism; D009243:NAD / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000960:Hypolipidemic Agents; D009243:NAD; C006012:fenofibric acid; D004051:Diethylhexyl Phthalate; D002994:Clofibrate; D011345:Fenofibrate