title: Clinical efficacy of increased dosages of milbemycin oxime for treatment of generalized demodicosis in adult dogs.
abstract: OBJECTIVE
  To determine the efficacy of increased dosages of milbemycin oxime in the treatment of generalized demodicosis.
  
  
  METHODS
  Prospective clinical trial.
  
  
  METHODS
  26 adult dogs with chronic generalized demodicosis.
  
  
  METHODS
  In phase 1, milbemycin was administered daily to 13 dogs at an approximate mean dosage of 1 mg/kg of body weight (PO) until 30 days after skin scrapings failed to detect mites. If the mite count had not decreased by 25% from the prior month's examination, the drug dosage was increased to approximately 2 mg/kg. Treatment was considered a failure if the mite count had not changed on 2 successive examinations. In phase 2 involving 13 other dogs, an approximate mean dosage of 2 mg/kg was used. If mite counts had not been reduced to 0 by 180 days, treatment was considered to have failed.
  
  
  RESULTS
  In phase 1, when milbemycin was administered at the initial low dosage, 6 dogs were considered to have been cleared of mites. One of these relapsed 2 months after discontinuation of treatment. For the 7 dogs not cleared of mites, the dosage was doubled. Two of these were never cleared of mites. In phase 2, 12 of 13 dogs were cleared of mites after 60 to 180 days of treatment.
  
  
  CONCLUSIONS
  High-dose milbemycin was effective in the treatment of generalized demodicosis.
mesh_terms: D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D018942:Macrolides; D008297:Male; D008924:Mite Infestations / Q000188:drug therapy / Q000662:veterinary*; D008925:Mites / Q000254:growth & development; D012008:Recurrence; D012867:Skin / Q000469:parasitology; D017211:Treatment Failure
chemical_list: D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; C078973:milbemycin oxime