[Cephalic cancer pain controlled by intraventricular administration of morphine and clonidine].
A 47-year-old woman suffered from a pharyngeal cancer causing pain only poorly relieved by high doses of oral morphine. Oral administration was switched to the intracerebroventricular (ICV) route but pain relief was only transient despite a daily dosage up to 1.5 mg of morphine. Finally an effective pain relief was achieved with increasing doses of clonidine (5 to 30 micrograms) in combination with morphine (1.5 mg) by ICV route. Neither arterial hypotension nor sedation occurred and the patient recovered transiently a better quality of life.
D000701:Analgesics, Opioid / Q000008:administration & dosage; D001921:Brain / Q000000981:diagnostic imaging; D002408:Catheters, Indwelling; D002552:Cerebral Ventricles; D003000:Clonidine / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D017809:Fatal Outcome; D005260:Female; D006261:Headache / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage*; D010610:Pharyngeal Neoplasms / Q000150:complications / Q000000981:diagnostic imaging / Q000188:drug therapy*; D014057:Tomography, X-Ray Computed
D000701:Analgesics, Opioid; D009020:Morphine; D003000:Clonidine
Douleurs céphaliques néoplasiques contrôlées par administration intraventriculaire de morphine et de clonidine.