Colorectal cancer. Epidemiology, etiology, pathogenesis and prevention.
Colorectal cancer (CRC) is a neoplasm with a steadily growing incidence in Western countries. Moreover the age of 50 and over is a critical risk factor. The relationship between dietary, environmental factors and CRC has been evaluated. At present, a number of genetic risk factors such as the genetic susceptibility, tumor suppressor genes and oncogenes are thought to play a major role. The correlation of CRC with adenomatous polyps and chronic inflammatory disease, ulcerative colitis in particular, has been evaluated. Prevention of CRC is mainly based on a rational diet and in the adoption of mass screening programmes.
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D015179:Colorectal Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000235:genetics; D004198:Disease Susceptibility; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D015212:Inflammatory Bowel Diseases / Q000150:complications; D007417:Intestinal Polyps / Q000150:complications; D008297:Male; D008875:Middle Aged; D009857:Oncogenes; D012307:Risk Factors; D012737:Sex Factors