title: [The effect neutron irradiation of Uranium 235 on the venom of Lachesis muta muta (Ofidia: Viperidae)].
abstract: The effect of irradiation of the aqueous solution of L. m. muta venom was evaluated with thermic neutrons from Uranium-235 employing doses of 1.61 to 5.19 Gray. The venom was examined for protein content by the Folin Lowry Method modified by Stauffer; for acute toxicity by intraperitoneal route estimation in mice and for immunochemical tests by the antigen-antibody reactions evaluation. Neutronic radiation affects all evaluated parameters in venom (decrease in protein content levels, increase of LD50 values and decrease in the number of precipitating antigen-antibody) as shown by immunodiffusion and immunoelectrophoresis.
mesh_terms: D000818:Animals; D005779:Immunodiffusion; D007122:Immunoelectrophoresis; D007928:Lethal Dose 50; D051379:Mice; D011506:Proteins / Q000737:chemistry / Q000528:radiation effects; D011829:Radiation Dosage; D012910:Snake Venoms / Q000737:chemistry / Q000528:radiation effects*; D014501:Uranium; D017819:Viperidae
chemical_list: D011506:Proteins; D012910:Snake Venoms; D014501:Uranium
vernacular_title: Efectos de la irradiación neutrónica del Uranio 235 sobre el veneno de Lachesis muta muta (Ofidia: Viperidae).