title: The iron-copper connection: the link to ceruloplasmin grows stronger.
abstract: A rare genetic defect in ceruloplasmin biosynthesis has provided the strongest evidence to date that ceruloplasmin is essential for iron metabolism and tissue distribution in humans. A aceruloplasminemia results in massive accumulations of iron in the liver and brain and is associated with retinal degeneration and diabetes.
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D001923:Brain Chemistry; D002570:Ceruloplasmin / Q000032:analysis / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D003300:Copper / Q000097:blood / Q000378:metabolism / Q000502:physiology*; D004247:DNA / Q000032:analysis / Q000737:chemistry / Q000235:genetics; D006801:Humans; D007501:Iron / Q000032:analysis / Q000097:blood / Q000378:metabolism*; D008099:Liver / Q000737:chemistry / Q000378:metabolism; D008969:Molecular Sequence Data
chemical_list: D003300:Copper; D004247:DNA; D007501:Iron; D002570:Ceruloplasmin