title: [Anesthetic management of a patient with microcephaly associated with cerebral atrophy].
abstract: We describe the management of a 35-year-old female with microcephaly, cerebral atrophy especially in frontal lobes, dwarfism and severe mental retardation. The patient underwent open reduction of fracture of the humerus neck suffered from traffic accident. Authors could not find any article on the anesthetic management of microcephaly but could locate some about mentally retarded patients claiming the difficulty in anesthetic induction as well as emergence and frequent incidence of convulsions. We anesthetized the patient with modified NLA with nitrous oxide-oxygen and interestingly very small doses of fentanyl (1.7 micrograms.kg-1) were required. The anesthetic and surgical courses were uneventful. The patient emerged immediately with intravenously administered naloxone and flumazenil with no excitement nor convulsion. We conclude that fentanyl is the drug of choice for mentally retarded patient with microcephaly and smaller doses per kg.weight are sufficient for orthopedic surgery.
mesh_terms: D000328:Adult; D001284:Atrophy / Q000150:complications; D005260:Female; D005283:Fentanyl; D005625:Frontal Lobe / Q000473:pathology*; D006801:Humans; D006810:Humeral Fractures / Q000601:surgery; D008607:Intellectual Disability; D008831:Microcephaly / Q000150:complications*; D009458:Neuroleptanalgesia / Q000379:methods*
chemical_list: D005283:Fentanyl