Expression and regulation of anti-thyroid autoimmunity directed against cultivated rat thyrocytes.
Lymph node cells from DA rats that had been exposed in utero to 131I in doses sufficient to interrupt thyroid development, attacked monolayers of normal syngeneic thyrocytes in vitro. Lymph node cells from normal DA rats did not damage syngeneic thyrocyte monolayers. Thyrocytes could be protected from damage provided they had been incubated with lymph node cells from normal syngeneic rats before the introduction of lymph node cells from 131I exposed rats. Spleen cells from both 131I exposed and normal rats attacked syngeneic thyrocytes. It is concluded that normal rats possess cells capable of downregulating anti-thyroid autoimmunity.
D000818:Animals; D002478:Cells, Cultured; D003602:Cytotoxicity, Immunologic / Q000528:radiation effects; D000949:Histocompatibility Antigens Class II / Q000378:metabolism; D007457:Iodine Radioisotopes; D008198:Lymph Nodes / Q000276:immunology / Q000528:radiation effects; D008214:Lymphocytes / Q000276:immunology / Q000528:radiation effects; D051381:Rats; D011919:Rats, Inbred Strains; D013154:Spleen / Q000276:immunology / Q000528:radiation effects; D013950:Thymus Gland / Q000276:immunology / Q000528:radiation effects; D013961:Thyroid Gland / Q000276:immunology* / Q000637:transplantation; D013967:Thyroiditis, Autoimmune / Q000235:genetics / Q000276:immunology*; D014185:Transplantation, Isogeneic
D000949:Histocompatibility Antigens Class II; D007457:Iodine Radioisotopes