Effect of substance P administration on vascular permeability in the rat oral mucosa and sublingual gland.
Neuropeptides, including substance P (SP) may play a role in neurogenic inflammation. Although SP-immunoreactive (SP-IR) axons are known to be present within the oral mucosa (OM) and salivary glands, the functional significance of SP in oral mucosa and sublingual salivary gland (SLG) is not fully understood. The present experiments were carried out to study the effects of SP infused into the left common carotid artery on vascular permeability in the OM and in the SLG of male rats. Vascular permeability was assessed on the basis of Evans Blue extravasation. Separate groups of animals received histamine (H1) receptor antagonist (chloropyramine, 10 mg kg-1 i.v.) or prostaglandin synthesis inhibitor (indomethacin, 4 mg kg-1 i.v.) prior to SP infusions. Infusion of SP in doses of 30 and 74 pmol min-1 increased the vascular permeability of OM by 162.3 +/- 16.3% (n = 8, p < 0.05) and 482.7 +/- 46.7% (n = 8, p < 0.001), respectively. SP in a dose of 15 pmol min-1 did not increase Evans Blue extravasation in OM (38.3 +/- 4.0 micrograms g-1, n = 8, compared to the control: 44.0 +/- 7.9 micrograms g-1, n = 8, NS).(ABSTRACT TRUNCATED AT 250 WORDS)
D000704:Analysis of Variance; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects*; D002339:Carotid Arteries; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D005029:Ethylenediamines / Q000494:pharmacology; D005119:Extravasation of Diagnostic and Therapeutic Materials; D006634:Histamine H1 Antagonists / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D018836:Inflammation Mediators / Q000502:physiology*; D007261:Infusions, Intra-Arterial; D008297:Male; D016555:Matched-Pair Analysis; D009061:Mouth Mucosa / Q000098:blood supply*; D051381:Rats; D017208:Rats, Wistar; D013361:Sublingual Gland / Q000098:blood supply*; D013373:Substance P / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000502:physiology
D016861:Cyclooxygenase Inhibitors; D005029:Ethylenediamines; D006634:Histamine H1 Antagonists; D018836:Inflammation Mediators; C004664:chloropyramine; D013373:Substance P; D007213:Indomethacin