The effect of betamethasone on phosphatidylcholine species composition in fetal rat lungs.
After betamethasone treatment, a significant diminution of the monoenoic phosphatidylcholine 32 carbon species (palmitoyl-palmitoleyl phosphatidylcholine and palmitoleyl-palmitoylphosphatidylcholine) and the phosphatidylcholine 34 carbon species (primarily palmitoyl-oleoyl-phosphatidylcholine) could be demonstrated both in absolute and relative terms, while the palmitic acid portion in the phosphatidylcholine fatty acids was nearly unchanged. This is consistent with a significant reduction of the palmitoleic and oleic acid portions of the total phosphatidylcholine fatty acids in the lungs of rat fetuses.
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001623:Betamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005333:Fetus; D005865:Gestational Age; D008168:Lung / Q000187:drug effects* / Q000196:embryology; D010713:Phosphatidylcholines / Q000378:metabolism*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar
D000893:Anti-Inflammatory Agents; D010713:Phosphatidylcholines; D001623:Betamethasone