New antifungal bithienylacetylenes from Blumea obliqua.
Two new bioactive bithienylacetylenes isolated from Blumea obliqua have been characterized as 5'-methyl-5-[4-(3-methyl-1-oxobutoxy)-1-butynyl]-2,2'- bithiophene [1] and 5'-hydroxymethyl-5-[butyl-3-en-1-yn]-2,2'-bithiophene isovaleroxy ester [2], respectively. Compounds 1 and 2 showed antifungal activity against Epidermophyton floccosum and Pleurotus ostreatus.
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D004821:Epidermophyton / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D011124:Polyporaceae / Q000187:drug effects; D013876:Thiophenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
C096949:5'-hydroxymethyl-5-(butyl-3-en-1-yn)-2,2'-biothiophene isovalerate; C096948:5'-methyl-5-(4-(3-methyl-1-oxobutoxy)-1-butynyl)-2,2'-bithiophene; D000935:Antifungal Agents; D013876:Thiophenes