title: Effects of honokiol and magnolol on acetylcholine release from rat hippocampal slices.
abstract: To study the possible mechanism through which honokiol and magnolol elicit their central depressant effects, we examined the influence of these two phenolic compounds on 25 mM K(+)-stimulated release of [3H]acetylcholine (ACh) from the rat's hippocampal slices. Honokiol, but not magnolol, elicited a concentration-dependent enhancement of K+-evoked ACh release. Addition of either tetrodotoxin, pilocarpine, or methoctramine had no effect on honokiol-enhanced ACh release. These results suggest that honokiol enhanced K(+)-evoked ACh release directly on hippocampal cholinergic terminals via receptors other than the M2 cholinergic subtypes.
mesh_terms: D000109:Acetylcholine / Q000378:metabolism*; D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology*; D002492:Central Nervous System Depressants / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects* / Q000378:metabolism; D066298:In Vitro Techniques; D017705:Lignans; D051381:Rats; D017207:Rats, Sprague-Dawley; D000498:Allyl Compounds; D010636:Phenols
chemical_list: D000109:Acetylcholine; D001713:Biphenyl Compounds; D002492:Central Nervous System Depressants; D017705:Lignans; C005498:magnolol; C005499:honokiol; D000498:Allyl Compounds; D010636:Phenols