Effect of multiple-dose activated charcoal on the clearance of high-dose intravenous aspirin in a porcine model.
OBJECTIVE
To study the effect of multiple-dose activated charcoal (MDAC) on salicylate clearance in pigs given high-dose i.v. aspirin.


METHODS
In a crossover design, six fasted pigs received 300 mg/kg i.v. aspirin followed by no treatment or MDAC (1 g/kg hourly for 6 doses by gastrostomy). Serum salicylate samples were obtained every 30 minutes for 6 hours.


RESULTS
The mean peak salicylate concentrations were 47.4 +/- 6.2 mg/dL and 48.4 +/- 3.9 mg/dL (P = .74), and the areas under the time-serum salicylate concentration curve over 6 hours were 171,000 +/- 24,000 mg.minute/L and 188,000 +/- 18,000 mg.minute/L for the control and treatment arms, respectively (P = .22). This study had a 90% power to detect a 30% difference between arms.


CONCLUSIONS
MDAC does not enhance the clearance of salicylate after administration of high-dose i.v. aspirin.
D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001241:Aspirin / Q000097:blood / Q000493:pharmacokinetics / Q000506:poisoning*; D002606:Charcoal / Q000627:therapeutic use*; D018592:Cross-Over Studies; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D008657:Metabolic Clearance Rate; D011041:Poisoning / Q000188:drug therapy; D012459:Salicylates / Q000097:blood; D020156:Salicylic Acid; D013552:Swine; D013997:Time Factors
D000931:Antidotes; D012459:Salicylates; D002606:Charcoal; D020156:Salicylic Acid; D001241:Aspirin