Normal excretion of m-hydroxymandelic acid in hypertensive patients.
o-Hydroxymandelic acid (OHMA), m-hydroxymandelic acid (MHMA) and p-hydroxymandelic acid (PHMA) were measured in the urine of 42 normotensive and 54 hypertensive patients. Patients having high urinary MHMA levels were all found to be ingesting medications containing m-synephrine (phenylephrine). These patients also had high levels of urinary m-synephrine which was excreted as the glucuronide. When patients ingesting m-synephrine were excluded from the analysis, no significant differences were observed between the two groups for the urinary excretion of OHMA, MHMA and PHMA.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging; D003971:Diastole; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D006880:Hydroxy Acids / Q000652:urine; D006973:Hypertension / Q000652:urine*; D008297:Male; D008333:Mandelic Acids / Q000652:urine*; D008875:Middle Aged; D010656:Phenylephrine / Q000378:metabolism / Q000627:therapeutic use*; D012737:Sex Factors; D013599:Systole
D006880:Hydroxy Acids; D008333:Mandelic Acids; C014600:4-hydroxymandelic acid; C024037:3-hydroxymandelic acid; C024038:2-hydroxymandelic acid; D010656:Phenylephrine