Down-regulation of mitochondrial mRNAs in the mdx mouse model for Duchenne muscular dystrophy.
In our search for genes up- or down-regulated genes in the mdx mouse model for Duchenne muscular dystrophy, we isolated a down-regulated mitochondrial DNA clone. In addition to this clone, all protein-coding mitochondrial genes tested had tissue-specific and age independent down-regulated expression. This implied mechanisms at the RNA level since no change in the mitochondrial DNA contents were detected. Cytochrome c oxidase activity showed the same range of down-regulated expression. These data provide a molecular basis for energetic metabolism modifications in mdx mice.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D017931:DNA Primers; D003576:Electron Transport Complex IV / Q000096:biosynthesis / Q000378:metabolism*; D005786:Gene Expression Regulation; D051379:Mice; D008810:Mice, Inbred C57BL; D018101:Mice, Inbred mdx; D008931:Mitochondria, Muscle / Q000378:metabolism*; D008969:Molecular Sequence Data; D024510:Muscle Development; D018482:Muscle, Skeletal / Q000254:growth & development / Q000378:metabolism; D009137:Muscular Dystrophy, Animal / Q000235:genetics* / Q000378:metabolism*; D009928:Organ Specificity; D016133:Polymerase Chain Reaction; D012313:RNA / Q000096:biosynthesis*; D012333:RNA, Messenger / Q000096:biosynthesis*; D000077278:RNA, Mitochondrial; D012016:Reference Values
D017931:DNA Primers; D012333:RNA, Messenger; D000077278:RNA, Mitochondrial; D012313:RNA; D003576:Electron Transport Complex IV