The ovarian renin-angiotensin system. A paracrine-intracrine regulator of ovarian function.
We present a review that considers the regulation of ovarian function by the ovarian renin-angiotensin system. Evidence is presented that shows the ovarian renin-angiotensin system can regulate normal ovarian function by paracrine and intracrine mechanisms. In addition, the complexity that is inherent in the renin-angiotensin system conferred by multiple biological angiotensin peptides and multiple receptors is discussed. Evidence that a dysfunctional OVRAS induces ovarian pathology such as polycystic ovarian disease is also presented.
D000818:Animals; D005260:Female; D006801:Humans; D010049:Ovarian Diseases / Q000378:metabolism / Q000503:physiopathology; D010053:Ovary / Q000502:physiology*; D012084:Renin-Angiotensin System / Q000502:physiology*