Changes in late auditory evoked potentials induced by growth hormone-releasing hormone (GHRH) but not somatostatin (SRIF) after peripheral administration in male controls.
To investigate possible influences of growth hormone-releasing hormone (GHRH) and somatostatin (SRIF) on auditory perceptional processes, 12 subjects received either placebo (sodium chloride 0.9%), GHRH (50 micrograms), or SRIF (100 micrograms) on different days. Late auditory evoked potentials (AEP) were computed and further analyzed by using the brain electric source analysis (BESA) method. Reduced late AEP latencies were observed following GHRH administration. In contrast, SRIF had no significant effects on the AEP. The changes in late auditory processing seen after administration of GHRH were most likely induced by a direct central nervous action.
D000161:Acoustic Stimulation; D000328:Adult; D000704:Analysis of Variance; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D013007:Growth Hormone-Releasing Hormone / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010919:Placebos; D011930:Reaction Time / Q000187:drug effects; D012016:Reference Values; D013004:Somatostatin / Q000494:pharmacology*
D010919:Placebos; D013004:Somatostatin; D013007:Growth Hormone-Releasing Hormone