Respiratory function deterioration is not time-linked with upper-limb onset in amyotrophic lateral sclerosis.
BACKGROUND
In amyotrophic lateral sclerosis (ALS), symptoms apparently spread following regional rules, and depending on the site of onset. We examined if respiratory function deterioration appears earlier or is more severe in patients with upper-limb onset.


METHODS
We compared the results of various pulmonary function tests (PFT) obtained at diagnosis depending on the site of onset in 49 ALS patients. In a longitudinal study, we compared the deterioration of forced vital capacity (FVC) in relation to the site of onset, and analyzed the time elapsed to reach values below 80% of predicted according to site of onset, and we compared the survival depending on the site of onset.


RESULTS
No significant differences in PFT were found in the upper-limb onset group in any of the analysis performed. No differences in survival were detected in any disease onset group.


CONCLUSIONS
Pulmonary function deterioration does not appear to be time-linked to arm onset in ALS.
D000328:Adult; D000368:Aged; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology*; D001132:Arm / Q000294:innervation; D003964:Diaphragm / Q000294:innervation; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007866:Leg / Q000294:innervation; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology; D009460:Neurologic Examination; D012133:Respiratory Paralysis / Q000175:diagnosis / Q000401:mortality / Q000503:physiopathology*; D015996:Survival Rate; D014797:Vital Capacity / Q000502:physiology