[The effect of indomethacin suppository in preventing mesenteric traction syndrome].
Mesenteric traction syndrome consists of cutaneous hyperemia with hypotension and tachycardia. NSAIDs could inhibit the phenomenon, but there are few reports about when to administer these drugs. In this study, we evaluated the effect of indomethacin on preventing mesenteric traction syndrome when administered preoperatively and just after induction of anesthesia. Thirty-six patients scheduled for abdominal hysterectomy were studied. Patients were randomized into three groups. Group C (n = 12); control, group T (n = 12); indomethacin 50 mg suppository just after induction of anesthesia, group P (n = 12); indomethacin 50 mg suppository about 90 min before incision. The effect of indomethacin was evaluated from the extent of cutaneous hyperemia. MTS was suppressed in group P, but not in group T (P < 0.05). We concluded that indomethacin suppository just after induction could not prevent mesenteric traction syndrome.
D000328:Adult; D000767:Anesthesia, Epidural; D000768:Anesthesia, General; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006940:Hyperemia / Q000517:prevention & control*; D007022:Hypotension / Q000517:prevention & control*; D007044:Hysterectomy; D007213:Indomethacin / Q000008:administration & dosage*; D007431:Intraoperative Complications / Q000517:prevention & control*; D008875:Middle Aged; D012867:Skin / Q000098:blood supply*; D013488:Suppositories; D013577:Syndrome; D013610:Tachycardia / Q000517:prevention & control*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013488:Suppositories; D007213:Indomethacin