AML M1 and M2 with eosinophilia and AML M4Eo: diagnostic and clinical aspects.
AML with eosinophilia belongs to the morphologic cytogenetic entity M1/M2 t(8;21) with the involvement of the genes AML1/ETO. These eosinophils differ only slightly from normal eosinophils with one rare exception i.e. Auer rods in eosinophils which has only been found on peroxidase staining: This subtype belongs to the good prognosis group of AML. AML with inv(16) (mostly M4Eo) per se is a morphologic-cytogenetic entity with inv(16),--rarely t(16;16), and the genes MYL 11/CBF beta involved. The eosinophils show special abnormalities. AML with inv(16) also belongs to the good prognosis group of AML.
D001853:Bone Marrow / Q000473:pathology; D002869:Chromosome Aberrations / Q000473:pathology; D025063:Chromosome Disorders; D002891:Chromosomes, Human, Pair 21; D002898:Chromosomes, Human, Pair 8; D003937:Diagnosis, Differential; D004802:Eosinophilia / Q000150:complications; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D015479:Leukemia, Myelomonocytic, Acute / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D014178:Translocation, Genetic