Blends of synthetic and natural polymers as drug delivery systems for growth hormone.
In order to overcome the biological deficiencies of synthetic polymers and to enhance the mechanical characteristics of natural polymers, two synthetic polymers, poly(vinyl alcohol) (PVA) and poly(acrylic acid) (PAA) were blended, in different ratios, with two biological polymers, collagen (C) and hyaluronic acid (HA). These blends were used to prepare films, sponges and hydrogels which were loaded with growth hormone (GH) to investigate their potential use as drug delivery systems. The GH release was monitored in vitro using a specific enzyme-linked immunosorbent assay. The results show that GH can be released from HA/PAA sponges and from HA/PVA and C/PVA hydrogels. The initial GH concentration used for sample loading affected the total quantity of GH released but not the pattern of release. The rate and quantity of GH released was significantly dependent on the HA or C content of the polymers.
D000180:Acrylic Resins / Q000737:chemistry* / Q000378:metabolism; D000818:Animals; D001696:Biomechanical Phenomena; D001704:Biopolymers; D003094:Collagen / Q000737:chemistry* / Q000378:metabolism; D003692:Delayed-Action Preparations; D016503:Drug Delivery Systems / Q000592:standards*; D005782:Gels / Q000737:chemistry; D013006:Growth Hormone / Q000008:administration & dosage* / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry* / Q000378:metabolism; D008855:Microscopy, Electron, Scanning; D011142:Polyvinyl Alcohol / Q000737:chemistry* / Q000378:metabolism; D011994:Recombinant Proteins / Q000378:metabolism / Q000493:pharmacokinetics
D000180:Acrylic Resins; D001704:Biopolymers; D003692:Delayed-Action Preparations; D005782:Gels; D011994:Recombinant Proteins; C006903:carbopol 940; D013006:Growth Hormone; D011142:Polyvinyl Alcohol; D006820:Hyaluronic Acid; D003094:Collagen