[Role of prostaglandins F and E in regulation of bronchial activity].
Prostaglandins (PGs) belong to the family of eicosanoids. A main substrate in their biosynthesis is arachidonic acid. Involvement of PGs in regulation of bronchial activity is a complex process and far from being fully understood. In 1968 it was shown that prostaglandins E1 and E2 cause bronchodilation, while prostaglandin F2a constricts an isolated human smooth muscle. The recent studies which revealed protective effects of PGE2 on bronchial reaction induced in patients by ultrasonically nebulized distilled water, allergen, metabisulfite, or exercise, revitalized interest among clinicians. Reports that PGE2 inhibits airways response in bronchial provocation with lysine aspirin, allow to believe that PGE2 plays a role in pathogenesis of aspirin induced asthma.
D001241:Aspirin / Q000009:adverse effects; D001249:Asthma / Q000139:chemically induced / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D016084:Bronchoconstriction / Q000502:physiology*; D016861:Cyclooxygenase Inhibitors / Q000009:adverse effects; D015444:Exercise / Q000502:physiology; D006801:Humans; D009130:Muscle, Smooth / Q000502:physiology; D011458:Prostaglandins E / Q000502:physiology*; D011460:Prostaglandins F / Q000502:physiology*
D016861:Cyclooxygenase Inhibitors; D011458:Prostaglandins E; D011460:Prostaglandins F; D001241:Aspirin
Udział prostaglandyn F i E w regulacji czynności oskrzeli.