Isolation of a highly cytopathic lentivirus from a nondomestic cat.
A feline immunodeficiency virus-like virus (FIV-Oma) isolated from a Pallas' cat (Otocolobus manul) is highly cytopathic in CrFK cells, in contrast to the chronic, noncytolytic infection established by an FIV isolate from a domestic cat (FIV-Fca). The virions have typical lentivirus morphology, density, and magnesium-dependent reverse transcriptase activity. The major core protein is antigenically cross-reactive with that of FIV-Fca; however, FIV-Oma transcripts do not cross-hybridize with FIV-Fca. A conserved region of the FIV-Oma pol gene has 76 to 80% nucleic acid identify with the corresponding pol regions of other feline lentiviruses and 64 to 69% identity with those of human, ovine, and equine lentiviruses.
D000818:Animals; D000835:Animals, Wild; D001483:Base Sequence; D015152:Blotting, Northern; D002335:Carnivora / Q000821:virology*; D002415:Cats; D002460:Cell Line; D017124:Conserved Sequence; D015751:Genes, pol; D006736:Horses; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000145:classification* / Q000302:isolation & purification* / Q000648:ultrastructure; D016086:Lentivirus / Q000145:classification* / Q000235:genetics / Q000302:isolation & purification; D008297:Male; D008854:Microscopy, Electron; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000302:isolation & purification; D012367:RNA, Viral / Q000302:isolation & purification; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D012756:Sheep; D014771:Virion / Q000648:ultrastructure
D012333:RNA, Messenger; D012367:RNA, Viral; D012194:RNA-Directed DNA Polymerase