Critical reading of the meta-analysis of clinical trials.
In this paper we shall present the general principles of meta-analysis and will then discuss the various factors needed to evaluate a meta-analysis: description of the problem; definition of the outcome(s) (primary and secondary); methods for identifying and selecting trials for inclusion; statistical methods used; and the presentation and discussion of the results. We shall then examine other problems such as the detection of bias, the validity of the information provided by the meta-analysis, the problem of heterogeneity, the sensitivity and robustness of the meta-analysis, quality criteria for a meta-analysis, and how to locate published meta-analyses. Finally we present a decision algorithm which should help answer the question: should and can the results from the meta-analysis be integrated into clinical practice?
D015982:Bias; D002986:Clinical Trials as Topic / Q000379:methods*; D006801:Humans; D015201:Meta-Analysis as Topic