Polymeric N-acetyl-D-glucosamine (chitin) induces prostaglandin E2 in dogs.
The level of prostaglandin E2 (PGE2) in the exudate induced by subcutaneous implantation of a complex formed from non-woven fabric of polyester (NWF) and polymeric N-acetyl-D-glucosamine (chitin) (chitin/NWF) or by implantation of NWF in dogs was measured by radioimmunoassay. The amount of PGE2 in the exudate induced by chitin/NWF was about five times as high as that in the exudate induced by NWF (p < 0.05), while the level of PGE2 in the exudate was similar to that in serum.
D000818:Animals; D002686:Chitin / Q000008:administration & dosage / Q000633:toxicity*; D015232:Dinoprostone / Q000097:blood / Q000378:metabolism*; D004285:Dogs; D004343:Drug Implants; D005122:Exudates and Transudates; D008297:Male
D004343:Drug Implants; D002686:Chitin; D015232:Dinoprostone