Timing of penicillin treatment influences the course of Streptococcus pneumoniae-induced middle ear inflammation.
Penicillin treatment timing, using the chinchilla pneumococcal otitis media model, was investigated. Early treatment (when approximately 10(3) pneumococcal CFU/ml was present in middle ear fluid) significantly accelerated inflammatory-cell influx, whereas late treatment (with approximately 10(7) pneumococcal CFU/ml present in middle ear fluid) did not. Therefore, antiinflammatory interventions will be needed early in the course of inflammation.
D000818:Animals; D002682:Chinchilla; D015169:Colony Count, Microbial; D010033:Otitis Media / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D010406:Penicillins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011008:Pneumococcal Infections / Q000188:drug therapy* / Q000382:microbiology / Q000473:pathology; D011817:Rabbits
D010406:Penicillins