[Comparison of blood pressure profile during exercise with benazepril 10 mg and benazepril 5 mg/hydrochlorothiazide 6.25 mg fixed combination].
This double-blind placebo-controlled study was designed to compare the efficacy of benazepril 10 mg (BZ 10) and the low-dose combination benazepril 5 mg/hydrochlorothiazide 6.25 mg (BZ + HCTZ) on exercise blood pressure in 71 patients with mild to moderate hypertension (diastolic blood pressure 95 to 114 mmHg at the end of a 2 week placebo run-in). A significant fall of systolic (SBF) and diastolic (DBP) blood pressure at rest was seen after a 4-week treatment period in the two active groups (-21.9/-10.3 mmHg with BZ 10, -19.5/-11.2 mmHg with BZ + HCTZ) and was greater in these two groups than in the placebo group (-7.5/-2.5 mmHg, p < 0.01). For each level of the exercise test on bicycle ergometer, SBP falls seen after 1 month were significant in the two active groups (from -15 to -23 mmHg depending on the level and treatment group). The evolution of the SBP/heart rate slope was significantly different among the two active groups in favour of the BZ 10 regimen. The exercise test proved to be a valuable tool to show any difference between two treatments with comparable efficacy on SBP/DBP at rest.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001552:Benzazepines / Q000008:administration & dosage* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D004232:Diuretics; D004311:Double-Blind Method; D004338:Drug Combinations; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D006852:Hydrochlorothiazide / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D049993:Sodium Chloride Symporter Inhibitors / Q000008:administration & dosage / Q000494:pharmacology
D000959:Antihypertensive Agents; D001552:Benzazepines; D004232:Diuretics; D004338:Drug Combinations; D049993:Sodium Chloride Symporter Inhibitors; D006852:Hydrochlorothiazide; C044946:benazepril
Comparaison du profil tensionnel d'effort du bénazépril 10 mg et de l'association fixe bénazépril 5 mg/hydrochlorothiazide 6.25 mg.