[The effect of dosage strength on the induction of chromosome aberrations and lung tumors in mice under the combined action of ionizing radiation and chemical substances].
In the experiment with combined influence of single or prolonged gamma irradiation (35 cGy) and chemical agents (urethanum, nitrogen oxide) on the induction of chromosome aberrations in bone marrow cells and lung tumor the effect of dose rate was studied. The frequency of chromosome aberrations increased with dose rate. Yet the correlation between the ratio of irreparable (stable) aberrations and dose rate was of inverse direction. The character of variations in lung adenoma frequency under multifactor influence in the case of prolonged irradiation (increase with dose rate decrease) supports the correlation between the level of stable aberrations in the pool of genetic lesions and the frequency of lung adenoma.
D000236:Adenoma / Q000453:epidemiology / Q000209:etiology*; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects / Q000648:ultrastructure; D002273:Carcinogens / Q000633:toxicity*; D002869:Chromosome Aberrations; D004307:Dose-Response Relationship, Radiation; D005720:Gamma Rays; D015994:Incidence; D008175:Lung Neoplasms / Q000453:epidemiology / Q000209:etiology*; D051379:Mice; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology / Q000209:etiology*; D009589:Nitrogen Oxides / Q000633:toxicity*; D013997:Time Factors; D014520:Urethane / Q000633:toxicity*
D002273:Carcinogens; D009589:Nitrogen Oxides; D014520:Urethane
Vliianie moshchnosti dozy na induktsiiu khromosomnykh aberratsiĭ i opukholeĭ legkikh u mysheĭ pri sochetannom deĭstvii ioniziruiushchego izlucheniia i khimicheskikh veshchestv.