title: [Study of clinically isolated new quinolones-resistant Haemophilus influenzae. Part 1].
abstract: A study was done to determine susceptibilities of Haemophilus influenzae that were obtained in our laboratory in 1994 to new quinolones (NQ) and other drugs. The results were as follows; 1. Among the 300 isolates, the detection frequency of NQ-resistant strains was 8.7% (26 strains), including isolates from chronic lower respiratory tract infections (22 strains) and those from middle meatus of nose (2 strains), etc. NQ-resistant strains were not isolated from children. 2. The cross resistance was studied for different NQs against NQ-resistant strains. Clavulanic acid/amoxicillin, cefteram, cefpodoxime, cefditoren, cefodizime (CDZM) and cefpirome showed strong antimicrobial activities against NQ-resistant strains. MIC90 of CEPs against all isolated strains including NQ-resistant strains and beta-lactamase producers was low. And the MIC90 of CDZM was < or = 0.025 microgram/ml, which was the lowest among all the antibiotics tested. 3. We found 47 strains (15.7%) of beta-lactamase producers among the 300 isolates, the frequency of beta-lactamase producing strains was high among strains obtained from children.
mesh_terms: D000890:Anti-Infective Agents / Q000494:pharmacology*; D002513:Cephamycins / Q000494:pharmacology; D004352:Drug Resistance, Microbial; D006192:Haemophilus Infections / Q000382:microbiology; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D010406:Penicillins / Q000494:pharmacology; D015363:Quinolones / Q000494:pharmacology*; D012141:Respiratory Tract Infections / Q000382:microbiology
chemical_list: D000890:Anti-Infective Agents; D002513:Cephamycins; D010406:Penicillins; D015363:Quinolones