Doxorubicin and ricin, a strongly synergistic combination in mouse leukemia.
The effect of combinations of doxorubicin (Adriamycin) and the cancerostatic plant lectin ricin on L1210 leukemic cells in mice was assessed by end-point dilution and spleen-colony assays. The combinations, which were well-tolerated by the mice, acted synergistically on leukemic cells in liver, spleen, and brain. In the bone marrow, a dramatically synergistic effect was obtained with combinations that had only slight effect on the survival of normal stem cells.
D000818:Animals; D001853:Bone Marrow / Q000473:pathology; D001921:Brain / Q000473:pathology; D003114:Colony-Forming Units Assay; D004317:Doxorubicin / Q000008:administration & dosage*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D007939:Leukemia L1210 / Q000188:drug therapy* / Q000473:pathology; D008099:Liver / Q000473:pathology; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D012276:Ricin / Q000008:administration & dosage*; D013154:Spleen / Q000473:pathology
D004317:Doxorubicin; D012276:Ricin