[A pharmacokinetic study of para-aminobenzoic acid administered into the rabbit eye by phonophoresis].
The pharmacokinetics of para-aminobenzoic acid (PABA) was studied after introduction of 3H-PABA in the rabbit eye by phonophoresis (1.8 ml 3H-PABA per eye, calculated from 10 muCi in 1 ml 0.9% sodium chloride). The label was found by liquid scintillation in all studied eye tissues, including the retina. Within 1 h the label content in the tissues was higher than within 3 after the isotope introduction. Thus, in addition to subcutaneous injection (Stroeva et al., 1992), another method of PABA introduction in the eye was used in order to further study its activity as a medicinal drug during treatment of degenerative processes in the retina.
D010129:4-Aminobenzoic Acid / Q000008:administration & dosage* / Q000493:pharmacokinetics*; D000818:Animals; D005123:Eye / Q000378:metabolism*; D015612:Phonophoresis; D011817:Rabbits; D013997:Time Factors; D014316:Tritium
D014316:Tritium; D010129:4-Aminobenzoic Acid
Issledovanie farmakinetiki paraaminobenzoĭnoĭ kisloty pri vvedenii v glaz krolika metodom fonoforeza.