title: Developmental, nutritional, and hormonal regulation of the pancreatitis-associated protein I and III gene expression in the rat small intestine.
abstract: BACKGROUND
  The pancreatitis-associated protein (PAP) I and III, but not PAP II, mRNAs are constitutively expressed in the small intestine of rats.
  
  
  METHODS
  We studied expression of both PAP I and PAP III mRNAs during development and on nutritional and hormonal manipulations.
  
  
  RESULTS
  Between day 20 of gestation and day 21 of age, PAP mRNAs could barely be detected. Their concentrations increased dramatically from day 21 to day 45 of age and remained constant thereafter. Rats adapted to a diet with low carbohydrate content showed a significant decrease in PAP mRNA concentrations. Finally, whereas thyroidectomy and ovariectomy induced a decrease in both mRNA concentrations, and adrenalectomy a limited decrease in PAP III mRNA only, diabetes and castration did not alter the expression of either gene.
  
  
  CONCLUSIONS
  Gene expression of PAP I and III mRNAs is regulated in a coordinate manner in the rat small intestine during development and on nutritional and hormonal manipulations.
mesh_terms: D000209:Acute-Phase Proteins / Q000235:genetics / Q000378:metabolism*; D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism; D005260:Female; D005786:Gene Expression Regulation; D006728:Hormones / Q000502:physiology; D007421:Intestine, Small / Q000378:metabolism*; D037181:Lectins, C-Type; D009747:Nutritional Physiological Phenomena / Q000502:physiology; D010052:Ovariectomy; D000073718:Pancreatitis-Associated Proteins; D011247:Pregnancy; D011270:Pregnancy, Animal; D012333:RNA, Messenger / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013965:Thyroidectomy
chemical_list: D000209:Acute-Phase Proteins; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006728:Hormones; D037181:Lectins, C-Type; D000073718:Pancreatitis-Associated Proteins; C000612141:REG3A protein, human; D012333:RNA, Messenger; C000612144:Reg3b protein, rat