title: Assessment of paroxetine-induced sexual dysfunction using the Changes in Sexual Functioning Questionnaire.
abstract: The Changes in Sexual Functioning Questionnaire (see Appendix) was developed as a brief clinical and research instrument to measure sexual function changes accompanying illness or the administration of medications. In a pilot study of patients with major depression being treated with paroxetine, the instrument was useful in delineating three groups of patients: patients who reported increased libido without sexual dysfunction, patients who developed anorgasmia with possible spontaneous resolution (medication side effect and development of tolerance), and patients with long-term sexual dysfunction unaffected by the medication. Change scores accurately differentiated global elements, changes associated with specific factors of sexual response, and drug-specific side effects. All patients had a therapeutic response to treatment with experiences of sexual functioning that could be categorized into one of the three groups.
mesh_terms: D000328:Adult; D003863:Depression / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D017374:Paroxetine / Q000009:adverse effects* / Q000627:therapeutic use*; D011569:Psychiatric Status Rating Scales; D012647:Self-Assessment; D020018:Sexual Dysfunctions, Psychological / Q000139:chemically induced*; D011795:Surveys and Questionnaires; D013997:Time Factors
chemical_list: D017374:Paroxetine