Species differences of amobarbital metabolism: dihydroxyamobarbital formation.
Amobarbital is almost completely metabolized in animals and man. The major metabolite is 3'-hydroxyamobarbital. The second major metabolite in dog, mice, hamsters, guinea pigs, and rats could be identified as 3',4'-dihydroxyamobarbital. A striking contrast between man and animals is the virtual absence of the diol in man and absence of amobarbital-N-glucoside in animals.
D000654:Amobarbital / Q000378:metabolism*; D000818:Animals; D001711:Biotransformation; D006224:Cricetinae; D004285:Dogs; D006168:Guinea Pigs; D006801:Humans; D006900:Hydroxylation; D008297:Male; D051379:Mice; D051381:Rats; D013045:Species Specificity
D000654:Amobarbital