[Implant fixation strength and osseointegration following systemic administration of recombinant factor XIII and factor XIII concentrate. Animal experiment with implant fixation strength and osseointegration of porous surface implants].
30 cylindrical commercially pure titanium fiber porous coated Ti6A14V implants were inserted press-fit into the proximal humeral portion of 30 sheep humeri to determine the systemic effect of recombinant factor XIII and placenta-derived factor XIII concentrate on bone ingrowth and on strength of fixation. For both the recombinant factor XIII and the factor XIII concentrate group the volume fraction of bone ingrowth and the strength of fixation was higher when compared with the control specimens. However the difference was only significant for the factor XIII concentrate group.
D000497:Alloys; D000818:Animals; D001696:Biomechanical Phenomena; D005176:Factor XIII / Q000008:administration & dosage / Q000494:pharmacology*; D005269:Femur / Q000166:cytology / Q000601:surgery; D008297:Male; D016348:Osseointegration / Q000187:drug effects*; D016062:Porosity; D019736:Prostheses and Implants; D011994:Recombinant Proteins / Q000494:pharmacology; D012756:Sheep; D014025:Titanium
D000497:Alloys; D011994:Recombinant Proteins; C031462:titanium alloy (TiAl6V4); D005176:Factor XIII; D014025:Titanium
Implantatverankerungsfestigkeit sowie Knocheneinwachsverhalten nach systemischer Gabe von rekombinantem Faktor XIII und Faktor XIII-Konzentrat. Eine tierexperimentelle Untersuchung mit Bestimmung von Implantatverankerungsfestigkeit sowie Knocheneinwachsverhalten bei porösen Oberflächenimplantaten.