Intracorporeal phenylephrine in the treatment of priapism.
OBJECTIVE
The effectiveness and complications of intracorporeal phenylephrine without aspiration or irrigation as a treatment for priapism were assessed.


METHODS
Nine consecutive patients who presented with priapism were treated with 0.5 mg. phenylephrine diluted in 2 cc normal saline injected directly into the corpus cavernosum. Blood pressure and pulse were measured before and after injection, and monitored every 15 minutes. If no detumescence was noted after 15 minutes the injection was repeated. Neither penile blood aspiration nor irrigation was performed.


RESULTS
Of 9 patients 8 responded with detumescence. The number of injections required ranged from 1 to 6. No changes in blood pressure, heart rate or side effects were observed.


CONCLUSIONS
We believe that this is a safe and effective method for treatment of priapism. Routine initial aspiration or irrigation of the corpora before intracorporeal injection of alpha-adrenergic agents does not appear to be necessary.
D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage*; D000317:Adrenergic alpha-Antagonists / Q000009:adverse effects; D000527:Alprostadil / Q000009:adverse effects; D001794:Blood Pressure / Q000187:drug effects; D007172:Erectile Dysfunction / Q000188:drug therapy; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007267:Injections; D008297:Male; D010208:Papaverine / Q000009:adverse effects; D010276:Parasympatholytics / Q000009:adverse effects; D010646:Phentolamine / Q000009:adverse effects; D010656:Phenylephrine / Q000008:administration & dosage*; D011317:Priapism / Q000139:chemically induced / Q000188:drug therapy* / Q000209:etiology; D011446:Prospective Studies; D013997:Time Factors; D014665:Vasodilator Agents / Q000009:adverse effects
D000316:Adrenergic alpha-Agonists; D000317:Adrenergic alpha-Antagonists; D010276:Parasympatholytics; D014665:Vasodilator Agents; D010656:Phenylephrine; D010208:Papaverine; D000527:Alprostadil; D010646:Phentolamine