The effects of human immunodeficiency virus infection on macrophage phagocytosis of Candida.
The effects of infection by human immunodeficiency virus (HIV) on phagocytic function towards Candida pseudotropicalis were tested using monocytotropic and nonmonocytotropic HIV strains on peripheral blood monocytes. There were no differences in either quantitative phagocytic activity or efficacy between the two infected and control mock-infected monocytes. Immunofluorescence for cytoplasmic p24 antigen and in situ hybridization for detection of HIV-specific RNA sequences revealed that very few cells (10(-4)) exhibit productive infection. Occasional cells with active infection as defined by microscopically detectable fluorescence labelling contained phagocytized yeasts.
D017088:AIDS-Related Opportunistic Infections / Q000276:immunology; D002175:Candida / Q000276:immunology* / Q000302:isolation & purification; D002177:Candidiasis / Q000150:complications / Q000276:immunology; D002478:Cells, Cultured; D006678:HIV / Q000276:immunology* / Q000302:isolation & purification; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D008264:Macrophages / Q000276:immunology / Q000382:microbiology; D009000:Monocytes / Q000276:immunology / Q000382:microbiology; D010587:Phagocytosis