title: Chloride channels of intracellular organelles.
abstract: Chloride channels are present in a variety of intracellular organelles (Golgi, endosomes, endoplasmic reticulum, and sarcoplasmic reticulum) where they serve largely to shunt the membrane potential created by other ion-translocating processes. Electrophysiological studies have shown that the Cl- channels of the endoplasmic and sarcoplasmic reticula facilitate the efflux of Ca2+. In the Golgi and some endosomes, the open Cl- channels (probably the cystic fibrosis transmembrane conductance regulator) favor accumulation of H+.
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D018118:Chloride Channels / Q000502:physiology*; D018870:Endoplasmic Reticulum, Rough / Q000378:metabolism; D011992:Endosomes / Q000378:metabolism; D006056:Golgi Apparatus / Q000378:metabolism; D006801:Humans; D006863:Hydrogen-Ion Concentration; D015388:Organelles / Q000378:metabolism*; D012519:Sarcoplasmic Reticulum / Q000378:metabolism
chemical_list: D018118:Chloride Channels; D002118:Calcium