[Genomic imprinting and human pathology. I. General Part].
Genetical as well as experimental embryology methods have permitted to uncover a very important feature of mammalian embryonic development: it has been shown that female and male genomic complements are differentially imprinted in such a way that contribution of both a maternally and a paternally derived genome are absolutely necessary for the embryo to complete its normal development. The paternal and maternal genomes are not equivalent and have a complementary role during development in mammals. The differences in activity of each parental genome result from an epigenetic modification of the genome during gametogenesis: the parental imprinting. The recent discovery of several mouse and human genes which are imprinted should permit to address new data of some diseases.
D000818:Animals; D004247:DNA / Q000235:genetics; D005314:Embryonic and Fetal Development; D018397:Equidae / Q000235:genetics; D005260:Female; D018392:Genomic Imprinting; D006648:Histocompatibility; D006736:Horses / Q000235:genetics; D006801:Humans; D008297:Male; D008745:Methylation; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics; D010063:Ovum / Q000166:cytology; D010375:Pedigree; D013094:Spermatozoa / Q000166:cytology
D004247:DNA
Imprinting genomico e patologia umana. I-Parte Generale.