Physiological effect of cholecystokinin on gastric emptying of liquid in functional dyspepsia.
OBJECTIVE
Early satiety and postprandial epigastric fullness are common symptoms in functional dyspepsia. Cholecystokinin (CCK), a mediator of satiety in humans, may be responsible for these symptoms through an increased effect on delaying gastric emptying.


METHODS
In five normal subjects and in five patients, gastric emptying of inert liquid mixed with technetium (Tc99m) was studied during i.v. perfusion of normal saline and of physiological concentrations of CCK octapeptide.


RESULTS
Administration of CCK significantly delayed emptying of inert liquid in patients and in normal subjects, and the effect was of similar magnitude in the two groups: residual gastric volumes at 90 min increased from 9.9 +/- 6.1 to 32.1 +/- 6.2% (p < 0.025) in controls and from 9.8 +/- 4.4 to 32.2 +/- 4.7% (p < 0.005) in patients during saline infusion in comparison with CCK infusion; also, prolongation of half emptying time was not different between the two groups (19.4 +/- 1.9 min to 39.4 +/- 15.2 min in controls and 19.5 +/- 3.0 min to 31.4 +/- 7.9 min in patients).


CONCLUSIONS
We conclude that CCK at physiological concentrations acts similarly in normal subjects and in patients with functional dyspepsia; this suggests that, if this hormone is normally released after a meal, a peripheral action of CCK through delayed gastric emptying is not responsible for increased postprandial satiety in functional dyspepsia.
D000328:Adult; D016022:Case-Control Studies; D002766:Cholecystokinin / Q000502:physiology*; D004415:Dyspepsia / Q000503:physiopathology*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D012844:Sincalide; D012965:Sodium Chloride; D013671:Technetium Tc 99m Sulfur Colloid; D013997:Time Factors; D014867:Water
D014867:Water; D012965:Sodium Chloride; D013671:Technetium Tc 99m Sulfur Colloid; D002766:Cholecystokinin; D012844:Sincalide