title: Proliferative activity in metastatic malignant melanoma: comparison of pre-treatment and post-treatment metastases.
abstract: In this study, the proliferative activity of malignant melanoma metastases was assessed before and after isolated limb perfusion chemotherapy by quantitating AgNORs, mitoses and PCNA activity. No significant difference in either AgNOR count, mitotic activity or PCNA index was observed. We conclude that AgNOR count, mitotic activity and PCNA index were not significantly effected by isolated limb perfusion chemotherapy.
mesh_terms: D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D002455:Cell Division / Q000187:drug effects; D005121:Extremities; D006801:Humans; D015918:Infusion Pumps, Implantable; D008545:Melanoma / Q000473:pathology* / Q000556:secondary* / Q000628:therapy; D008940:Mitotic Index / Q000187:drug effects; D009336:Necrosis; D009697:Nucleolus Organizer Region / Q000187:drug effects / Q000473:pathology; D011183:Postoperative Complications / Q000188:drug therapy / Q000473:pathology*; D011184:Postoperative Period; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis; D012878:Skin Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000601:surgery
chemical_list: D000970:Antineoplastic Agents; D018809:Proliferating Cell Nuclear Antigen