title: Potent antiplatelet, anti-inflammatory and antiallergic isoflavanquinones from the roots of Abrus precatorius.
abstract: Five isoflavanquinones have been isolated from the roots of Abrus precatorius L. (Leguminosae). Three of them are new and designated as abruquinones D, E, and F. The pharmacological activities of the isoflavanquinones have been evaluated. The results indicated that abruquinones A, B, and D exhibited remarkable inhibitory effects on the platelet aggregation. The IC50 of abruquinones A and B for the inhibition of the platelet aggregation induced by arachidonic acid (AA) and collagen were less than 5 micrograms/ml, and of abruquinone D, was less than 10 micrograms/ml for that induced by AA. On the other hand, abruquinones A, B, D, and F showed strong anti-inflammatory and antiallergic effects. The IC50 of abruquinones A, B, D, and F for the inhibition of superoxide formation were less than 0.3 micrograms/ml, for the inhibition of the release of both beta-glucuronidase and lysozyme from rat neutrophils and the release of both beta-glucuronidase and histamine from mast cells were less than 1 microgram/ml.
mesh_terms: D000818:Animals; D018926:Anti-Allergic Agents / Q000302:isolation & purification* / Q000494:pharmacology; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000302:isolation & purification* / Q000494:pharmacology; D001578:Benzopyrans / Q000302:isolation & purification / Q000494:pharmacology; D016227:Benzoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D007887:Fabaceae; D007529:Isoflavones / Q000302:isolation & purification* / Q000494:pharmacology; D008407:Mast Cells / Q000187:drug effects / Q000502:physiology*; D015394:Molecular Structure; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology*; D018517:Plant Roots; D010946:Plants, Medicinal; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013481:Superoxides / Q000097:blood
chemical_list: D018926:Anti-Allergic Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001578:Benzopyrans; D016227:Benzoquinones; D007529:Isoflavones; D010975:Platelet Aggregation Inhibitors; D013481:Superoxides; C093391:abruquinone A