title: Comparison of tensile strength of cyanoacrylate tissue adhesive closure of lacerations versus suture closure.
abstract: OBJECTIVE
  To compare the tensile strength of lacerations closed with cyanoacrylate tissue adhesive, with suture, and with a combination of tissue adhesive and suture.
  
  
  METHODS
  Randomized, controlled animal model study.
  
  
  METHODS
  Animal care facility.
  
  
  METHODS
  Sixteen albino guinea pigs.
  
  
  METHODS
  Four incisions to deep fascia were created on the dorsum of each animal. Lacerations were closed with either tissue adhesive alone, tissue adhesive with subcutaneous suture, percutaneous suture alone, or percutaneous suture with subcutaneous suture. After 4 days, the breaking strengths of all wound closures were measured.
  
  
  RESULTS
  Wound closures made with cyanoacrylate tissue adhesive alone exhibited significantly less tensile strength at 4 days than closures made by the other three methods. Wound closures made with combined percutaneous and subcutaneous sutures were significantly stronger than all other groups.
  
  
  CONCLUSIONS
  Wound closures made with cyanoacrylate tissue adhesive alone have less tensile strength at 4 days than those made with tissue adhesive and subcutaneous suture or those closed by traditional suture methods.
mesh_terms: D000818:Animals; D003487:Cyanoacrylates / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D011897:Random Allocation; D013536:Suture Techniques; D013718:Tensile Strength; D013997:Time Factors; D014014:Tissue Adhesives / Q000627:therapeutic use*; D014950:Wounds, Penetrating / Q000628:therapy*
chemical_list: D003487:Cyanoacrylates; D014014:Tissue Adhesives