[Effect of processing on specific toxicity of radix Achyranthis bidentatae].
To activate Epstein-barr virus in Raji cells in vitro the lowest activation concentrations of ether extracts from Radix Achyranthis Bidentatae unprepared (I), stir-baked with wine (II) and stir-baked with salt (III) required were 0.8.20 and 0.16 micrograms/ml respectively. 5 microliters (equal to 250 mg herb weight)/ear of these extracts had inflammatory effect on mouse ear skin in 4 hours. Ethanol extract of I at concentration 0.04-125 mg/ml did not increase the chromosomal aberration rates in CHL cells. The decoctions of I, II, and III given orally at 15 g/kg x 3d showed no effect on micronucleus rates in mouse bone marrow. Ethanol extracts of I, II, and III at 10 g/kg x 10d did not show any evident antifertility action.
D000818:Animals; D002869:Chromosome Aberrations; D004365:Drugs, Chinese Herbal / Q000633:toxicity*; D005260:Female; D005298:Fertility / Q000187:drug effects; D006358:Hot Temperature; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D011247:Pregnancy; D013678:Technology, Pharmaceutical
D004365:Drugs, Chinese Herbal