title: Monoclonal antibody against the polymorphic site distinguishes apolipoprotein E4 from other isoforms.
abstract: Apolipoprotein E4 has been confirmed as a genetic risk factor for Alzheimer's disease. Although several hypotheses have been advanced to explain how the inheritance of apolipoprotein E isoforms affects the rate of Alzheimer's disease expression, the mechanism whereby apolipoprotein E is involved in the pathogenesis of Alzheimer's disease is still uncertain. To clarify the way in which the apolipoprotein E4 isoform differs from the others, we generated a monoclonal antibody specifically reactive with the apolipoprotein E4 isoform. This antibody suggests that the polymorphic site is important in differentiating the ApoE4 isoform from others.
mesh_terms: D000544:Alzheimer Disease / Q000453:epidemiology / Q000235:genetics; D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000737:chemistry* / Q000235:genetics* / Q000276:immunology; D016367:Baculoviridae; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000737:chemistry / Q000276:immunology; D011110:Polymorphism, Genetic; D011994:Recombinant Proteins / Q000737:chemistry / Q000276:immunology; D012307:Risk Factors
chemical_list: D000911:Antibodies, Monoclonal; D053327:Apolipoprotein E4; D001057:Apolipoproteins E; D010446:Peptide Fragments; D011994:Recombinant Proteins