title: Urinary clearance of atrial natriuretic peptide in Pekin ducks.
abstract: To quantify the renal excretion of atrial natriuretic peptide (ANP) in birds, synthetic ANP was infused intravenously into conscious Pekin ducks at rates of 10, 30 and 90 ng/kg per min for 30 min and the relationships between plasma and urine ANP concentrations were monitored by RIA. The infusions of ANP produced dose-dependent elevations in the plasma concentrations of the hormone; however, urinary concentrations and excretion rates did not change significantly from the basal values of 142.2 +/- 21.5 pg/ml and 26.4 +/- 4.5 pg/min per kg respectively. The metabolic clearance rate of ANP remained constant at each infusion dose (approximately 200 ml/min per kg). The urinary clearance rates (< 0.3 ml/min per kg) indicated that the fraction of ANP cleared from the blood via the urine was less than 0.2%. Clearly, excretion of intact ANP via this route is not a quantitatively important means of elimination for this hormone in birds.
mesh_terms: D000818:Animals; D009320:Atrial Natriuretic Factor / Q000097:blood / Q000494:pharmacology / Q000652:urine*; D004305:Dose-Response Relationship, Drug; D004372:Ducks / Q000097:blood / Q000652:urine*; D005260:Female; D007668:Kidney / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008657:Metabolic Clearance Rate; D009994:Osmolar Concentration
chemical_list: D009320:Atrial Natriuretic Factor