[An immunohistochemical study of HLA-DR expression in salivary glands from patients with Sjogren's syndrome].
Specimens of salivary gland tissue from 21 cases of SS were analyzed by ABC immunohistochemistry technicue with a monoclonal antibody to HLA-DR. The results showed that positive immunostaining for HLA-DR were found in duct cells, acinar cells and a part of infiltrating cells respectively. The proportions of duct and acinar cells expressing HLA-DR were not increased between SS and controls. However, there are differences in their staining intensity. The HLA-DR expression on the epithelial cells in SS was most intense than in controls. Our data suggest that the HLA-DR expression of SS may be regarded as an important factor in local immune rections.
D000328:Adult; D000368:Aged; D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D012469:Salivary Glands / Q000276:immunology*; D012859:Sjogren's Syndrome / Q000276:immunology*
D006684:HLA-DR Antigens