[Experimental and clinical studies of degradable starch microspheres in the treatment of hepatic neoplasm: Part 1. Experimental study].
An Experimental study was performed to evaluate arterial blood flow changes caused with the intra-arterial administration of degradable starch microspheres (DSM). Hemodynamic and histological changes caused by the intra-arterial administration of DSM were investigated in rabbit kidneys. The degree of blockade of arterial blood flow was correlated with the dose of DSM, and angiography reflected these changes reliably. Histological changes were also dependent on the dose of DSM. Less than 6mg administration had caused little or no histological change. However massive necrosis of the renal tubules had been found with more than 15mg of DSM administration. The degree of blockade of arterial blood flow and histological change could be controlled by changes in the dose of DSM.
D000818:Animals; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007269:Injections, Intra-Arterial; D007668:Kidney / Q000473:pathology*; D008297:Male; D008863:Microspheres; D009336:Necrosis; D011817:Rabbits; D012079:Renal Circulation; D013213:Starch / Q000008:administration & dosage* / Q000009:adverse effects
D013213:Starch