title: Ambulatory 24-hour manometric and pH metric evidence of permanent impairment of clearance capacity in patients with esophageal atresia.
abstract: Dysphagia and gastroesophageal reflux (GER) probably caused by structural disorganization of the esophagus occur frequently after repair of tracheoesophageal fistula (TEF), and the extent to which they may improve beyond childhood is not known. The aim of the present study is to assess by combined ambulatory 24-hour manometry and pH-metry the esophageal peristaltic activity and acid clearing capacity in adolescents and adults who had been operated on for TEF at birth. Twenty-two patients, aged 17.1 +/- 4.5 years (mean +/- SD), were examined with combined three-channel manometry and two-channel pH-metry followed by endoscopy and biopsy. Although they considered themselves healthy, on careful interrogation, 16 (72%) were found to have dysphagia, 13 (59%) had heartburn, 10 (45%) had foreign body impaction, and 7 (31%) had chronic respiratory tract disease. GER was detected in 12 (54%) patients (5 with histological esophagitis), 10 of whom had a pattern of prolonged nocturnal episodes with very slow clearance. All patients had diminished contractile activity with low-amplitude and short-duration waves that decreased from 0.53 +/- 0.35 waves per minute to 0.28 +/- 0.2 waves per minute during sleep. Propulsive activity was uniformly disorganized, with peristaltic sequences being few (less than 50% overall) and incomplete (above 80%). Finally, the acid-clearing capacity was nil; the proportions of ineffective sequences were above 90% for all periods considered, including sleep and mealtimes. The motor behavior of nonrefluxing and refluxing patients was identical despite the differences in esophageal acid exposure.(ABSTRACT TRUNCATED AT 250 WORDS)
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D003680:Deglutition Disorders / Q000175:diagnosis / Q000503:physiopathology; D004063:Digestion; D004933:Esophageal Atresia / Q000601:surgery*; D015154:Esophageal Motility Disorders / Q000175:diagnosis* / Q000503:physiopathology; D004942:Esophagitis, Peptic / Q000175:diagnosis / Q000503:physiopathology; D004947:Esophagus / Q000503:physiopathology; D005260:Female; D005547:Foreign Bodies / Q000175:diagnosis / Q000503:physiopathology; D005744:Gastric Acid; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000503:physiopathology; D006356:Heartburn / Q000175:diagnosis / Q000503:physiopathology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008365:Manometry; D018670:Monitoring, Ambulatory; D009119:Muscle Contraction; D010528:Peristalsis; D012140:Respiratory Tract Diseases / Q000175:diagnosis / Q000503:physiopathology; D012890:Sleep; D014138:Tracheoesophageal Fistula / Q000601:surgery*