title: Favourable outcome in idiopathic ventricular fibrillation with treatment aimed at prevention of high sympathetic tone and suppression of inducible arrhythmias.
abstract: OBJECTIVE
  In the absence of an obvious cause for cardiac arrest, patients with idiopathic ventricular fibrillation are difficult to manage. A subset of patients has inducible arrhythmias. In others sympathetic excitation plays a role in the onset of the cardiac arrest. This study evaluates a prospective stepped care approach in the management of idiopathic ventricular fibrillation, with therapy first directed at induced arrhythmias and secondly at adrenergic trigger events.
  
  
  METHODS
  University Hospital.
  
  
  METHODS
  10 consecutive patients successfully resuscitated from idiopathic ventricular fibrillation.
  
  
  METHODS
  Programmed electrical stimulation to determine inducibility, followed by serial drug treatment. Assessment of pre-arrest physical activity and mental stress status by interview, followed by beta blockade. Cardioverter-defibrillator implantation in non-inducible patients not showing significant arrest related sympathetic excitation.
  
  
  METHODS
  Recurrent cardiac arrest or ventricular tachycardia.
  
  
  RESULTS
  Five patients were managed with serial drug treatment and four with beta blockade. In one patient a defibrillator was implanted. During a median follow up of 2.8 years (range 6 to 112 months) no patient died or experienced defibrillator shocks. One patient had a recurrence of a well tolerated ventricular tachycardia on disopyramide.
  
  
  CONCLUSIONS
  Idiopathic ventricular fibrillation may be related to enhanced sympathetic activation. Prognosis may be favourable irrespective of the method of treatment. Whether the present approach enhances prognosis of idiopathic ventricular fibrillation remains to be determined. However, it may help to avoid potentially hazardous antiarrhythmic drugs or obviate the need for implantation of cardioverter-defibrillators.
mesh_terms: D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D002985:Clinical Protocols; D003131:Combined Modality Therapy; D017147:Defibrillators, Implantable; D004206:Disopyramide / Q000627:therapeutic use; D004558:Electric Stimulation; D004562:Electrocardiography; D005260:Female; D005424:Flecainide / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D005082:Physical Exertion; D013315:Stress, Psychological; D014693:Ventricular Fibrillation / Q000188:drug therapy / Q000209:etiology / Q000628:therapy*
chemical_list: D000889:Anti-Arrhythmia Agents; D004206:Disopyramide; D005424:Flecainide