Gastric mucosal phosphatidylcholine hydroperoxide increases during cold water-immersion restraint stress in rats.
To know the role of lipid peroxidation in the pathogenesis of stress-induced gastric mucosal lesions, we performed the present study. Both gastric mucosal lesions and gastric mucosal phosphatidylcholine hydroperoxides (PCOOH) levels during cold water-immersion restraint (CWIR) stress were measured by the chemiluminecence-HPLC method in Sprague-Dawley rats. Ulcer indices increased time-dependently during the stress. Gastric mucosal PCOOH levels also significantly increased and reached a peak level (250% of untreated level) after 2 hr of stress. These results suggest that lipid peroxidation may play an important role in the pathogenesis of gastric mucosal lesions induced CWIR stress.
D000818:Animals; D003080:Cold Temperature; D005753:Gastric Mucosa / Q000378:metabolism*; D007101:Immersion; D015227:Lipid Peroxidation; D008297:Male; D010713:Phosphatidylcholines / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology / Q000473:pathology; D013312:Stress, Physiological / Q000378:metabolism*; D013997:Time Factors; D014867:Water
D010713:Phosphatidylcholines; C057590:phosphatidylcholine hydroperoxide; D014867:Water