Potential targets for autosomal SCID mutations.
Significant advances have been recently made in the molecular characterization of genes that encode proteins with activities that are directly, or indirectly, involved in the assembly of antigen receptor variable region genes. Such genes are candidate targets for human autosomal mutations that lead to severe combined immune deficiencies characterized by a lack of both T and B cells.
D000818:Animals; D015321:Gene Rearrangement / Q000276:immunology*; D006801:Humans; D009154:Mutation / Q000276:immunology*; D011946:Receptors, Antigen / Q000235:genetics*; D016511:Severe Combined Immunodeficiency / Q000235:genetics*
D011946:Receptors, Antigen