title: [Cocaine abuse--with special reference to cerebrovascular complications].
abstract: The role of drug abuse as a risk factor for cerebrovascular events has been underestimated, particularly in patients with juvenile stroke. The drug most often associated with acute cerebrovascular events is cocaine. After cocaine hydrochloride abuse intracerebral hemorrhages or subarachnoid hemorrhages--predominantly caused by ruptured aneurysms or arteriovenous malformations--are by far the most frequently observed cerebrovascular complications, whereas on abuse with the alkaloidal form ("crack") intracranial hemorrhages and ischemic strokes are encountered with equal frequency. In most cases, the time interval between drug abuse and the cerebrovascular event is less than 3 hours. Several pathophysiological mechanisms are discussed as serving as triggers for the cerebrovascular event, either alone or in combination. No specific antidote to cocaine is known. Nevertheless drug screening (urine analysis) should be performed immediately to allow optimal management of patients with drug-associated acute cerebrovascular events, especially in cases with juvenile stroke.
mesh_terms: D002561:Cerebrovascular Disorders / Q000139:chemically induced*; D003042:Cocaine / Q000009:adverse effects*; D016578:Crack Cocaine / Q000009:adverse effects; D006801:Humans; D012307:Risk Factors; D019966:Substance-Related Disorders / Q000150:complications* / Q000534:rehabilitation
chemical_list: D016578:Crack Cocaine; D003042:Cocaine
vernacular_title: Cocain-Missbrauch--unter besonderer Berücksichtigung zerebrovaskulärer Komplikationen.