Selective transmission of hepatitis C virus in vivo and in vitro.
A human plasma containing quasi-species of hepatitis C virus (HCV) was inoculated to a chimpanzee and to human lymphocytic cell lines, HPB-Ma clone 10-2, AD HPB, and Daudi, which support replication of HCV. Among six different hypervariable region (HVR) sequences detected in the inoculum, the same two were recovered both in vivo and in vitro.
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002478:Cells, Cultured; D017931:DNA Primers / Q000737:chemistry; D016174:Hepacivirus / Q000235:genetics / Q000254:growth & development*; D006526:Hepatitis C / Q000635:transmission*; D006801:Humans; D008969:Molecular Sequence Data; D002679:Pan troglodytes; D012367:RNA, Viral / Q000032:analysis; D014779:Virus Replication
D017931:DNA Primers; D012367:RNA, Viral