[Rational concepts and the study of active molecules against various trypanosomiases].
Several sets of compounds, active against different trypanosomes, Trypanosoma brucei and Trypanosoma cruzi are presented, the lethal doses for some of them being less than the micro-molar concentration. These compounds are designed by taking advantage of two metabolic features of these parasites, glucose metabolism and oxidative stress.
D000818:Animals; D014355:Chagas Disease / Q000188:drug therapy; D016054:DNA, Protozoan / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D005634:Fructose-Bisphosphate Aldolase / Q000037:antagonists & inhibitors; D005947:Glucose / Q000378:metabolism; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases / Q000037:antagonists & inhibitors; D006019:Glycolysis / Q000187:drug effects; D006593:Hexokinase / Q000037:antagonists & inhibitors; D006801:Humans; D009547:Nifurtimox / Q000494:pharmacology; D018384:Oxidative Stress / Q000187:drug effects; D011073:Polyamines / Q000378:metabolism; D014344:Trypanocidal Agents / Q000008:administration & dosage / Q000494:pharmacology*; D014346:Trypanosoma brucei brucei / Q000187:drug effects* / Q000378:metabolism; D014349:Trypanosoma cruzi / Q000187:drug effects* / Q000378:metabolism; D014353:Trypanosomiasis, African / Q000188:drug therapy
D016054:DNA, Protozoan; D004791:Enzyme Inhibitors; D011073:Polyamines; D014344:Trypanocidal Agents; D005987:Glyceraldehyde-3-Phosphate Dehydrogenases; D006593:Hexokinase; D005634:Fructose-Bisphosphate Aldolase; D005947:Glucose; D009547:Nifurtimox
Conception rationnelle et étude de molécules actives contre les différentes trypanosomiases.