Molecular evidence that in vivo isotype switching occurs within the germinal centers.
D017951:Antigen Presentation; D001402:B-Lymphocytes / Q000276:immunology*; D017637:Clonal Deletion; D018858:Germinal Center / Q000276:immunology*; D006801:Humans; D017578:Immunoglobulin Class Switching; D018448:Models, Immunological; D014066:Palatine Tonsil / Q000166:cytology / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D014158:Transcription, Genetic