title: Renal calculi in primary hyperaldosteronism.
abstract: Increased urinary calcium (Ca++) excretion and the presence of negative Ca++ balance is well documented in primary hyperaldosteronism. However, renal calculi as a major manifestation of this disorder has not previously been described. This report describes a patient who presented with renal calculi in association with primary hyperaldosteronism. We believe that primary hyperaldosteronism was a major pathogenetic factor in the formation of renal calculi since the increased urinary excretion of Ca++ and uric acid noted at onset declined following a short-term spironolactone administration and remission from renal calculi has persisted following initial nephrolithotomy and continued spironolactone therapy, which also corrected hypertension and hypokalemia, a hallmark of this disorder.
mesh_terms: D006801:Humans; D006929:Hyperaldosteronism / Q000150:complications*; D007669:Kidney Calculi / Q000209:etiology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009403:Nephrostomy, Percutaneous; D013148:Spironolactone / Q000627:therapeutic use
chemical_list: D013148:Spironolactone