[The mechanisms of the recovery of nerve ending functions during the reinnervation of skeletal muscle].
At the experiments on the frog cutaneous-pectoris muscle the nerve terminal functions in course of reinnervation process were investigated by electrophysiological and morphological methods. At the 20-25th days after the nerve crushing the nerve terminal response, which reflect the nerve terminal currents, formed the propagated action potential, were restored and the arising of evoked transmitter secretion occurred. The regenerating terminals are characterized by a low amplitude and altered shape of responses, by small velocity of the excitation propagation and the low level of evoked transmitter release. The 4-aminopyridine effect at the new formed nerve terminals was quite another, than at the intact nerve terminals. This data concluded, that the membrane of regenerating nerve terminal have a low density and a small gradient of sodium channels along the terminal and have not a calcium-activated potassium channels. It was proposed, that different kinds of channels are inserted into the nerve endings membrane at the different periods of the reinnervation process.
D015761:4-Aminopyridine / Q000494:pharmacology; D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D004558:Electric Stimulation; D008839:Microelectrodes; D008857:Microscopy, Interference; D008859:Microscopy, Polarization; D009121:Muscle Denervation; D018482:Muscle, Skeletal / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D009411:Nerve Endings / Q000187:drug effects / Q000502:physiology*; D009416:Nerve Regeneration / Q000187:drug effects / Q000502:physiology*; D017729:Presynaptic Terminals / Q000187:drug effects / Q000502:physiology; D011895:Rana ridibunda; D013997:Time Factors
D015761:4-Aminopyridine
Mekhanizmy vosstanovleniia funktsiĭ nervnykh okonchaniĭ v protsesse reinnervatsii skeletnoĭ myshtsy.