Induction of protein droplet (alpha 2 mu-globulin) nephropathy in male rats after short-term dosage with 1,8-cineole and l-limonene.
As part of a series of short-term studies on peppermint oil constituents for their possible induction of the encephalopathy found with peppermint oil, 1,8-cineole and l-limonene were studied. Groups of 10 male Wistar rats were given 0, 500, or 1000 mg 1,8-cineole/kg body wt./day or 0, 800, or 1600 mg l-limonene/kg body wt./day for 28 days. 1,8-Cineole and l-limonene both induced accumulation of protein droplets containing alpha 2 mu-globulin in proximal tubular epithelial cells in male rats. These results suggest that both 1,8-cineole and l-limonene possibly belong to the group of chemicals characterized by their induction of excessive alpha 2 mu-globulin accumulation. Neither of the 2 substances induced encephalopathy.
D000510:Alpha-Globulins / Q000378:metabolism*; D000818:Animals; D003511:Cyclohexanols; D053138:Cyclohexenes; D000077591:Eucalyptol; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism* / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D000077222:Limonene; D008297:Male; D036142:Mentha piperita; D008610:Menthol / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D039821:Monoterpenes; D010938:Plant Oils / Q000008:administration & dosage / Q000737:chemistry / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes / Q000008:administration & dosage / Q000633:toxicity*
D000510:Alpha-Globulins; D003511:Cyclohexanols; D053138:Cyclohexenes; D039821:Monoterpenes; D010938:Plant Oils; D013729:Terpenes; D008610:Menthol; D000077222:Limonene; C015424:peppermint oil; D000077591:Eucalyptol