[Influence of hematopoietic growth factors on transfusion support following autologous bone marrow transplantation].
OBJECTIVE
To determine the effect of haematopoietic growth factors (HGFs) (G-CSF and GM-CSF) on supporting platelet and red blood cell (RBC) transfusions in patients undergoing autologous bone marrow transplantation.


METHODS
We retrospectively evaluated the transfusion requirements of 44 patients over three months post-transplant. Ten of these patients received recombinant human G-CSF and ten received GM-CSF. This group was compared with the control group, formed of 24 patients who did not received HGFs. The patients receiving HGFs did not differ significantly from those who did not receive growth factor with regard to age, sex, diagnosis, number of bone marrow cells infused and clinical factors affecting the efficacy of platelet and/or RBC transfusion (fever, infection, amphotericin B treatment, bleeding episodes). Statistical analysis of the results was made using the Mann-Whitney U test, with a p value significant at the 0.05 level.


RESULTS
No significant effect of HGFs on platelet cell recovery was observed, but there was a trend for the time taken to recovery to increase. The median time of duration of platelet support dependence in the HGFs treated group was 19 days (range 7-100), compared with 15 days (range 3-65) in the control group. The number of platelet transfusions was 8.5 (2-43) and 7.5 (1-33) respectively. The treated patients received a median of 57 units of platelets (range 12-363), compared with 49 in the controls (range 7-206). In NHL there was a reduced need for platelet transfusions in HGFs group. In HD, HGFs increased platelet usage considerably (p < 0.05), although these groups were formed by only 5 and 7 patients respectively. The median RBC usage was the same between both patient groups (6 units of packed red cells).


CONCLUSIONS
In our patients, the administration of HGFs has no beneficial effect on blood product requirements.
D000293:Adolescent; D000328:Adult; D016913:Blood Component Transfusion / Q000706:statistics & numerical data*; D016026:Bone Marrow Transplantation; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D012189:Retrospective Studies
D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor
Influencia de los factores de crecimiento hematopoyéticos en el soporte transfusional tras trasplante autólogo de medula ósea.