[The antioxidant correction of cytogenetic disorders in viral hepatitis].
It has been established that in the acute period of viral hepatitis (VH) the level of chromosome aberrations is 4.4-fold and 6.6-fold that of the norm in VHA and VHB respectively, with the chromatid type aberrations predominating. Frequency of metaphases with chromosome aberrations in substantially higher in patients selected from those categories of individuals working at chemical enterprises and persons living in the zone of exposure to discharges from huge metallurgical works and coking plants. There is a correlation between the markedness of cytogenetic disturbances and degree of cellular immune deficiency. Use of antioxidants (tocopheroli acetas, parmidin, quercetin) in the complex of drug preparations contributes to the normalization of cytogenetic indices and reduction of frequency of protracted and chronic forms of hepatitis.
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D002869:Chromosome Aberrations; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D006506:Hepatitis A / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D006509:Hepatitis B / Q000188:drug therapy* / Q000235:genetics / Q000276:immunology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D008875:Middle Aged; D013997:Time Factors
D000975:Antioxidants
Korrektsiia antioksidantami tsitogeneticheskikh narusheniĭ pri virusnom gepatite.