title: Influence of Helicobacter pylori colonization on histological grading of chronic gastritis in Korean patients with peptic ulcer.
abstract: OBJECTIVE
  We conducted an analysis of correlation between histological grading of chronic gastritis and the presence of H. pylori infection to investigate if H. pylori influences histological severity of chronic gastritis in Korean patients with peptic ulcers.
  
  
  METHODS
  Gastroscopic antral biopsy specimens and peripheral venous blood were taken from 80 patients with gastric or duodenal ulcers. H. pylori was identified microscopically in sections with Giemsa staining and quantitative grading of cultured H. pylori was reported on a scale 0 to 3. The histopathological features of biopsy specimens were reported according to the Sydney classification of chronic gastritis. Serum gastrin and pepsinogen concentrations were measured by radioimmunoassay.
  
  
  RESULTS
  H. pylori was identified in 62.5%(20 of 32 GU, 30 of 48 DU) of the study group. Gastric clonization rate of H. pylori did not increased with age. Forty of 50 biopsy specimens with H. pylori and also 23 of 30 biopsy specimens without H. pylori showed active chronic gastritis. There was no significant correlation overall between the presence of H. pylori and histological grading of chronic gastritis, including activity, and also no association was found between the quantitative grading of H. pylori and the histological grading of chronic gastritis. With and without H. pylori, a mean of serum gastrin concentration(79.4 +/- 4.30 pg/ml and 80.2 +/- 31.9 pg/ml)showed no significant difference, but a mean of serum pepsinogen concentration(87.7 +/- 41.6 ng/ml and 119 +/- 34.4 ng/ml) showed significant difference between the populations with and without H. pylori(p = 0.001).
  
  
  CONCLUSIONS
  The influence of H. pylori on histological grading of chronic gastritis in Korean is less than that in prior studies of Western countries, and further investigation of pathogenesis of H. pylori in chronic gastritis and peptic ulceration is necessary.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002908:Chronic Disease; D005260:Female; D005756:Gastritis / Q000473:pathology*; D016480:Helicobacter pylori / Q000472:pathogenicity*; D006801:Humans; D007723:Korea; D008297:Male; D008875:Middle Aged; D010435:Pepsinogens / Q000097:blood; D010437:Peptic Ulcer / Q000382:microbiology*
chemical_list: D010435:Pepsinogens