title: Effect of Beconase nasal spray on olfactory function in post-nasal polypectomy patients: a prospective controlled trial.
abstract: Numerous studies have postulated the possible benefit of corticosteroids on olfaction in patients with nasal/sinus disease. Twenty-nine patients with bilateral nasal polyps were included in our study using strict selection criteria to reduce other aetiologies of olfactory dysfunction. The University of Pennsylvania Smell Identification Test (UPSIT) was performed pre-operatively on the right and left nostrils separately. Following intranasal polypectomy the patients received a six-week course of beclomethasone nasal spray (Beconase) to one nostril only, with the other acting as a control. The UPSIT scores were again obtained for each nostril separately. Wilcoxon Signed Rank test revealed no statistically significant difference in UPSIT scores between treated and untreated nostrils (p = 0.31; power 70 per cent; ES = 0.47). We conclude that topical beclomethasone does not improve olfaction following nasal polypectomy.
mesh_terms: D000281:Administration, Intranasal; D000328:Adult; D000336:Aerosols; D000368:Aged; D001507:Beclomethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009298:Nasal Polyps / Q000601:surgery*; D011184:Postoperative Period; D011446:Prospective Studies; D012903:Smell / Q000187:drug effects*
chemical_list: D000336:Aerosols; D001507:Beclomethasone