title: Autoimmune thyroid disease in primary Sjögren's syndrome.
abstract: OBJECTIVE
  To evaluate the prevalence of autoimmune thyroid disease and thyroid dysfunction in patients with primary Sjögren's syndrome.
  
  
  METHODS
  Thyroid function of 33 patients with primary Sjögren's syndrome was clinically and biochemically evaluated. Thyroid hormones and autoantibodies against thyroid peroxidase, thyroglobulin, and thyroid hormones were measured.
  
  
  RESULTS
  Autoimmune thyroid disease and thyroid dysfunction were found in 15 cases (45%): autoimmune thyroiditis in 8 (24%); autoimmune hyperthyroidism in 2 (6%); and reversible iodine-induced hypothyroidism in the remaining 5 (15%). One or more of the evaluated autoantibodies were detected in 8 euthyroid patients (24%). Overall, the prevalence of autoantibodies against thyroid peroxidase, thyroglobulin, thyroxine, and triiodothyronine was 45%, 18%, 42%, and 36%, respectively.
  
  
  CONCLUSIONS
  The high prevalence of autoimmune thyroid disease and thyroid dysfunction found in primary Sjögren's syndrome, using sensitive immunologic and thyroid function tests, suggest that both diseases are more frequently associated than it was previously thought, and should be sought clinically and by laboratory tests in all patients with primary Sjögren's syndrome.
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000097:blood; D001327:Autoimmune Diseases / Q000097:blood / Q000150:complications* / Q000276:immunology; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications; D007037:Hypothyroidism / Q000150:complications; D007453:Iodide Peroxidase / Q000276:immunology; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D012859:Sjogren's Syndrome / Q000097:blood / Q000150:complications* / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology; D013959:Thyroid Diseases / Q000097:blood / Q000150:complications* / Q000276:immunology; D013963:Thyroid Hormones / Q000097:blood / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000150:complications
chemical_list: D001323:Autoantibodies; D013963:Thyroid Hormones; D013954:Thyroglobulin; D007453:Iodide Peroxidase