Isolation and identification of Lom-SG-SASP, a salivation stimulating peptide from the salivary glands of Locusta migratoria.
From a methanolic extract of about 2500 salivary glands of Locusta migratoria a peptide was isolated which stimulates cAMP production in the salivary glands and salivation. Maldi-TOFMS revealed a mass of 1779 Da. The primary structure of the peptide is NH2-EVGDLFKEWLQGNMN-COOH. The peptide is named Locusta migratoria-Salivary Gland-Salivation Stimulating Peptide (Lom-SG-SASP) because of its simulating effect on salivation. Lom-SG-SASP displays no relevant sequence similarities with any other known peptide from vertebrate or invertebrate sources. The effect of synthetic Lom-SG-SASP on cAMP production in the salivary glands and on salivation is discussed.
D000595:Amino Acid Sequence; D000818:Animals; D000242:Cyclic AMP / Q000096:biosynthesis*; D006110:Grasshoppers / Q000737:chemistry*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D012471:Salivary Proteins and Peptides / Q000302:isolation & purification* / Q000502:physiology; D012472:Salivation / Q000502:physiology
C096413:Lom-SG-SASP peptide; D012471:Salivary Proteins and Peptides; D000242:Cyclic AMP