A cytotoxic diacetylene from Dendropanax arboreus.
The crude ethanol extract from the leaves of Dendropanax arboreus (Araliaceae) from Monteverde, Costa Rica, exhibits cytotoxic activity against Hep-G2, A-431, H-4IIE, and L-1210 tumor cell lines, but is not toxic against normal hepatocytes. The active component has been isolated by activity-directed separation and identified by 1H- and 13C-NMR spectroscopy as the acetylenic compound cis-1,9,16-heptadecatriene-4,6-diyne-3,8-diol.
D000480:Alkynes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D002478:Cells, Cultured; D053280:Diynes; D004354:Drug Screening Assays, Antitumor; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D006801:Humans; D008099:Liver / Q000166:cytology / Q000187:drug effects; D051379:Mice; D005894:Panax / Q000737:chemistry*; D010946:Plants, Medicinal; D051381:Rats; D014407:Tumor Cells, Cultured
D000480:Alkynes; D000972:Antineoplastic Agents, Phytogenic; D053280:Diynes; D005233:Fatty Alcohols; C096571:1,9,16-heptadecatriene-4,6-diyne-3,8-diol