title: [Pharmacokinetics of lidocaine and bupivacaine after peribulbar block with additional hyaluronidase].
abstract: OBJECTIVE
  To assess the time course of plasma concentrations of lidocaine and bupivacaine associated with hyaluronidase for peribulbar block.
  
  
  METHODS
  Prospective study.
  
  
  METHODS
  Ten patients (mean age = 71 +/- 11 yrs, mean weight 63 +/- 10 kg) scheduled for cataract surgery with lens implantation.
  
  
  METHODS
  Lidocaine 2% (5.5 mL = 110 mg) and bupivacaine 0.5% (5.5 mL = 27.5 mg) associated with hyaluronidase (80 IU) were injected supra and infra-orbitally, in patients premedicated with midazolam. Blood samples wer0 collected at constant time intervals from the end of infiltration until the 6th hour. The plasma concentrations of local anesthetics were measured with the HPLC technique.
  
  
  RESULTS
  The median plasma peak concentration was 1.74 mg.L-1 after 10 min for lidocaine, and 0.52 mg.L-1 after 7.5 min for bupivacaine respectively.
  
  
  CONCLUSIONS
  The similar delays of occurrence of peak concentrations confirm that liposolubility is not the only factor of diffusion of local anaesthetics from the periocular fat into the blood stream. The peak concentrations are far below the alleged toxic concentrations. When associated with hyaluronidase, the peak concentrations occur as rapidly as after endotracheal or paracervical administration.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000772:Anesthesia, Local / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage; D002045:Bupivacaine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D002387:Cataract Extraction; D004338:Drug Combinations; D005260:Female; D006801:Humans; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage*; D007910:Lenses, Intraocular; D008012:Lidocaine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D000779:Anesthetics, Local; D004338:Drug Combinations; D008012:Lidocaine; D006821:Hyaluronoglucosaminidase; D002045:Bupivacaine
vernacular_title: Pharmacocinétique de la lidocaïne et de la bupivacaïne après bloc péribulbaire avec adjonction d'hyaluronidase.