title: Effects of a continuous lipid infusion on glucose metabolism in critically ill patients.
abstract: The effects of lipid administration on carbohydrate oxidation rate remain controversial, particularly in critically ill patients. The aim of this study was to determine the effects of these patients of a continuous lipid infusion on glucose metabolism using indirect calorimetry and stable isotopes. We studied seven patients, mechanically ventilated, during two consecutive 24-h periods. Throughout the first period they received a continuous infusion of glucose (2 mg.kg-1.min-1) and amino acids. During the second period, in addition to the glucose, they received a continuous infusion of 1 mg.kg-1.min-1 of long-chain triglycerides emulsion. Substrate oxidation rates were calculated from pulmonary gas exchange and nitrogen excretion measurements. Glucose kinetic parameters were measured using primed constant infusions of [6,6-2H2]glucose and [1-13C]glucose. The lipid infusion did not modify the glucose metabolism parameters; 45% of the lipid supply was stored.
mesh_terms: D000368:Aged; D002153:Calorimetry, Indirect; D002245:Carbon Dioxide; D016638:Critical Illness / Q000628:therapy*; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007262:Infusions, Intravenous; D008055:Lipids / Q000008:administration & dosage* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010288:Parenteral Nutrition; D012119:Respiration
chemical_list: D008055:Lipids; D002245:Carbon Dioxide; D005947:Glucose