[The synthesis and study of the acute toxicity and anthelmintic activity of new 2-methylthiobenzimidazoles].
Several derivatives of 2-methylthiobenzimidazoles were synthesized and assayed for anthelmintic activity. Following these studies, 2-methylthio-5-(1-chloronaphthyloxy-2)-6-chlorobenzimidazole (G-1557) has been selected as a tichinellacide for detailed investigations.
D000818:Animals; D000969:Antinematodal Agents / Q000032:analysis / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D001562:Benzimidazoles / Q000032:analysis / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D005260:Female; D008297:Male; D008463:Mebendazole / Q000627:therapeutic use; D051379:Mice; D013055:Spectrophotometry, Infrared; D017160:Trichinella spiralis; D014235:Trichinellosis / Q000188:drug therapy
D000969:Antinematodal Agents; D001562:Benzimidazoles; D008463:Mebendazole
Sintez, izuchenie ostroĭ toksichnosti i protivogel'mintnoĭ aktivnosti novykh 2-metiltiobenzimidazolov.