Effect of calcium supplements and stage of lactation on the calcium absorption efficiency of lactating women accustomed to low calcium intakes.
The effect of calcium intake on the calcium absorption efficiency from 100 mL cow milk was measured in lactating Gambian mothers habituated to a low-calcium diet [mean intake 7.08 mmol (283 mg)/d], and compared with UK lactating mothers consuming high-calcium diets [mean intake 29.2 mmol (1168 mg)/d] by using a double stable-isotope technique (oral 44Ca and intravenous 42Ca). In a double-blind trial starting 9 d postpartum, Gambian mothers were given a calcium supplement [17.85 mmol (714 mg)/d] or placebo for 12 mo. At 3 and 12 mo postpartum, mean (+/- SEM) calcium absorption from isotopically enriched milk was 52.3 +/- 3.1% (n = 25) and 47.2 +/- 4.8% (n = 24) in the unsupplemented Gambian mothers and 48.8 +/- 2.8% (n = 28) and 42.9 +/- 3.7% (n = 24) in the supplemented mothers, respectively. There was no effect of supplementation or stage of lactation on the efficiency of calcium absorption. At 3 mo postpartum the UK mothers absorbed 32.2 +/- 3.8% of the isotopically enriched calcium added to milk, which was significantly less than that of the Gambian mothers (P < 0.01).
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D000818:Animals; D002118:Calcium / Q000008:administration & dosage / Q000172:deficiency* / Q000493:pharmacokinetics*; D002127:Calcium Isotopes; D002136:Calcium, Dietary / Q000032:analysis / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005260:Female; D005527:Food, Fortified; D005714:Gambia; D006801:Humans; D007275:Injections, Intravenous; D007774:Lactation / Q000502:physiology*; D013058:Mass Spectrometry; D008892:Milk / Q000737:chemistry / Q000592:standards; D006113:United Kingdom
D002127:Calcium Isotopes; D002136:Calcium, Dietary; D002118:Calcium