title: [Assessment of gentamicin dosage in patients before planned surgical operation].
abstract: The study included 18 patients, whom before planned surgical operation administered preventively gentamicin in the dose 3 x 80 mg/24 h i.m. After 24 hours the venous blood was taken before administration of the next dose of the drug and the concentration of gentamicin was determined by FPIA method. The subtherapeutic level of the drug was found in 15 patients (83%), therapeutic level - in 2 patients (11%) and toxic level in 1 patient (6%). It seems, that in patients after surgical operation, in whom after the prophylactic administration the treatment of gentamicin is continued, it is necessary the monitoring of the concentration of this antibiotic.
mesh_terms: D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage*; D019072:Antibiotic Prophylaxis; D002763:Cholecystectomy; D004334:Drug Administration Schedule; D005264:Femoral Fractures / Q000601:surgery; D005839:Gentamicins / Q000008:administration & dosage*; D006230:Hand Injuries / Q000601:surgery; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D012086:Reoperation; D014648:Varicose Veins / Q000601:surgery
chemical_list: D000900:Anti-Bacterial Agents; D005839:Gentamicins
vernacular_title: Ocena dawkowania gentamycyny u chorych przed planowanym zabiegiem chirurgicznym.