title: Efficacy of oral micronized progesterone in the treatment of luteal phase defects.
abstract: OBJECTIVE
  Vaginal progesterone suppositories are an accepted treatment for infertility attributed to luteal phase defects. Although oral micronized progesterone may be preferable to suppositories for many patients, there are no studies on its use for patients with luteal phase defects. This study evaluated the efficacy of oral micronized progesterone for the treatment of luteal phase defects.
  
  
  METHODS
  Seven women with luteal phase defects previously corrected by vaginal suppositories were administered oral micronized progesterone (200 mg by mouth three times a day). Endometrial biopsies were performed to evaluate treatment efficacy. Questionnaires were used to assess side effects, including sedation.
  
  
  RESULTS
  On oral micronized progesterone, all patients had in-phase endometrial biopsies. Despite complaints of drowsiness, the majority of patients preferred the oral formulation over the vaginal route of administration.
  
  
  CONCLUSIONS
  We conclude that oral micronized progesterone is efficacious in the treatment of luteal phase defects.
mesh_terms: D000284:Administration, Oral; D002214:Capsules; D005260:Female; D006801:Humans; D008183:Luteal Phase; D010570:Pessaries; D011374:Progesterone / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood; D016896:Treatment Outcome
chemical_list: D002214:Capsules; D011374:Progesterone