title: Retention and excretion of 95Zr-95Nb in humans.
abstract: This note describes the retention and excretion of 95Zr-95Nb in humans based on a recent CANDU experience and a literature survey of reported cases. Two data bases, QUEST and INIS were used for the survey. Three reported cases were discovered: two for occupational exposures and one for public exposure from nuclear weapons fallout. Human lung retention from these three cases, plus whole body retention and some limited fecal excretion data from a recently occurred exposure at a CANDU station, were reviewed and tested against predictions based on ICRP Publication 30 model. Based on the fits of this model to the reported data it seems that the three occupational exposures exhibit class Y behavior while the public exposure exhibits class W behavior. For only one case is the chemical compound known with certainty: ZrO2. Zirconium oxides are currently classified as class W in ICRP Publications 30 and 54. This work confirms a suggestion that oxides of zirconium be classified as class Y and should be taken into account by the ICRP in its future publications.
mesh_terms: D005243:Feces / Q000737:chemistry; D006801:Humans; D007700:Kinetics; D008168:Lung / Q000378:metabolism; D008962:Models, Theoretical; D009556:Niobium / Q000493:pharmacokinetics*; D009689:Nuclear Warfare; D016273:Occupational Exposure; D011847:Radioactive Fallout; D011868:Radioisotopes / Q000493:pharmacokinetics*; D013997:Time Factors; D015040:Zirconium / Q000493:pharmacokinetics*
chemical_list: D011847:Radioactive Fallout; D011868:Radioisotopes; D009556:Niobium; D015040:Zirconium