Biomechanical signals in the coronary artery triggering the metabolic processes during cardiac overload.
Peculiarities in structure and deformability of epicardial conduit coronary arteries are described. The thin wall of animal coronary artery contrasts the human coronary artery in which the remarkable wall thickness is due namely by the intima thickness. Deformation in length and diameter of conduit coronary arteries, due to the left and right ventricle volume increase, has been defined in non-beating canine heart. Ramus interventricularis anterior being firmly tethered to the myocardium undergoes about 3 times larger deformation than ramus circumflexus. In anaesthetized dogs a 30% increase in blood pressure, elicited by aortic constriction, induces an increase in diameter of coronary artery, in segment length, in blood flow and consequently in shear stress which represents a load for circumferentially running smooth muscle bundles, longitudinally running smooth muscle bundles, as well as for the endothelium. The above load lasting 4 h is already reflected by an increase in total RNA content and [14C] leucin incorporation in the left ventricle myocardium in the wall of ramus interventricularis anterior, not in ramus circumflexus. The findings fit completely with the different range of deformation of both the above coronary branches and indicates an increase in proteosynthesis not only in myocardium, but in ramus interventricularis anterior as well. An increase in ornithindecarboxylase activity in coronary wall leading to an increase in biogenic polyamines, is present in the case only, when blood pressure increase is induced by infusion of noradrenaline.
D000818:Animals; D001158:Arteries / Q000502:physiology; D001794:Blood Pressure; D003326:Coronary Circulation; D003331:Coronary Vessels / Q000502:physiology*; D004285:Dogs; D066298:In Vitro Techniques; D007930:Leucine / Q000378:metabolism; D009131:Muscle, Smooth, Vascular / Q000502:physiology; D009206:Myocardium / Q000378:metabolism*; D009955:Ornithine Decarboxylase / Q000378:metabolism; D014176:Protein Biosynthesis; D012313:RNA / Q000378:metabolism; D013314:Stress, Mechanical; D017539:Tunica Intima / Q000502:physiology; D016277:Ventricular Function, Left / Q000502:physiology
D012313:RNA; D009955:Ornithine Decarboxylase; D007930:Leucine