Development and biochemical characterization of a double-virus-inactivated factor VIII preparation.
This paper describes the development of a double-virus-inactivated preparation. The original goal was to inactivate and/or remove parvovirus from plasma-derived factor VIII. More recently, attention has also been focused on the controversial issue of transmission of the non-lipid-coated hepatitis A virus by preparations of factor VIII which have been solvent/detergent-treated and purified by ion-exchange chromatography.
D000998:Antiviral Agents / Q000737:chemistry*; D002852:Chromatography, Ion Exchange; D003902:Detergents; D004355:Drug Stability; D005169:Factor VIII / Q000302:isolation & purification*; D006507:Hepatovirus / Q000302:isolation & purification*; D006801:Humans; D017992:Parvovirus / Q000302:isolation & purification*; D011786:Quality Control; D012997:Solvents; D014841:von Willebrand Factor / Q000032:analysis
D000998:Antiviral Agents; D003902:Detergents; D012997:Solvents; D014841:von Willebrand Factor; D005169:Factor VIII