title: Gastroesophageal reflux prophylaxis decreases the incidence of pharyngocutaneous fistula after total laryngectomy.
abstract: Pharyngocutaneous fistula is a serious complication after laryngectomy. Gastric fluid is known to cause severe laryngopharyngeal injury and poor mucosal healing. This study was designed to evaluate the effects of a gastroesophageal reflux prophylaxis regimen on the incidence of fistula after laryngectomy. Twenty-one consecutive patients were entered in the study. Patients with positive resection margins were excluded from the overall analysis. All patients had a Connell's two-layer closure of the pharynx with absorbable suture, suction drainage of the neck, postoperative tube feeding, and prophylactic antibiotics. All patients were started on an antireflux regimen postoperatively composed of continuous tube feeds, intravenous ranitidine, and intravenous metoclopramide hydrochloride. Patients were followed postoperatively with Gastrografin swallows and clinically for 8 weeks. The control group consisted of retrospectively studied patients managed identically except for the antireflux prophylaxis. The two groups were well matched for factors reported to influence the rate of pharyngocutaneous fistula formation. The control group had six fistulae (26%) and an average of 16.5 days of hospital stay. The study group had no fistulae and an average of 11.5 days of hospital stay (P = .02). This study suggests that gastroesophageal reflux may predispose to fistula formation after laryngectomy and that mechanical and pharmacological prophylaxsis decreases postoperative morbidity and length of hospital stay.
mesh_terms: D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use; D017577:Cutaneous Fistula / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D005402:Fistula / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D005764:Gastroesophageal Reflux / Q000150:complications / Q000517:prevention & control*; D006801:Humans; D015994:Incidence; D007825:Laryngectomy / Q000009:adverse effects*; D008787:Metoclopramide / Q000627:therapeutic use; D008875:Middle Aged; D010608:Pharyngeal Diseases / Q000453:epidemiology / Q000209:etiology / Q000517:prevention & control*; D011899:Ranitidine / Q000627:therapeutic use
chemical_list: D000897:Anti-Ulcer Agents; D000932:Antiemetics; D011899:Ranitidine; D008787:Metoclopramide