Cell culture systems as tools for studying age-related changes in skeletal muscle.
Two aspects of muscle cell phenotype that may be affected by aging are amenable to study in vitro: proliferative potential and ability to differentiate. These processes in primary myoblast cultures as well as in established myoblast cell lines will be examined, and the usefulness of these in vitro systems in addressing fundamental molecular mechanisms of muscle aging will be discussed.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000235:genetics / Q000473:pathology*; D000818:Animals; D018929:Cell Culture Techniques; D002454:Cell Differentiation; D002455:Cell Division; D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D015870:Gene Expression; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D051379:Mice; D008875:Middle Aged; D009124:Muscle Proteins / Q000235:genetics; D018482:Muscle, Skeletal / Q000166:cytology* / Q000378:metabolism; D010641:Phenotype; D010751:Phosphopyruvate Hydratase / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics
D009124:Muscle Proteins; D012333:RNA, Messenger; D010751:Phosphopyruvate Hydratase