Anti-ulcerogenic evaluation of the methanolic extracts of some indigenous medicinal plants of Pakistan in aspirin-ulcerated rats.
Anti-ulcerogenic activity of the methanolic extracts of 4 medicinal plants were studied in aspirin-induced gastric ulcers in rats. Their effects on the volume of gastric juice secreted, acid output, peptic activity, mucin activity and curative ratio were recorded. Bauhinia racemosa (flower buds) decreased the ulcer index significantly, and Moringa pterygosperma (flower buds) showed some decrease in the ulcer index. Trianthema pentandra (whole plant) did not show any decrease in the acid or pepsin content or any increase in mucin; however, it showed a highly significant decrease in the ulcer index. Cordia latifolia (ripened fruit) did not however decrease the ulcer index.
D000284:Administration, Oral; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001241:Aspirin / Q000008:administration & dosage / Q000633:toxicity*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D007887:Fabaceae; D005744:Gastric Acid / Q000378:metabolism; D005750:Gastric Juice / Q000378:metabolism; D000432:Methanol / Q000737:chemistry; D009077:Mucins / Q000378:metabolism; D010154:Pakistan; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010946:Plants, Medicinal; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy*
D000897:Anti-Ulcer Agents; D009077:Mucins; D010936:Plant Extracts; D001241:Aspirin; D000432:Methanol