The association of the serotonin metabolite, 5-HIAA, to the lysosomal enzyme N-acetyl-beta-glucosaminidase.
Twenty-one medication-free patients with generalized anxiety disorder (GAD) collected urine samples for 5-hydroxyindoleacetic acid (5-HIAA) and N-acetyl-beta-glucosaminidase (NAG). Nine patients with no comorbid psychiatric diagnosis showed a significant association between 5-HIAA and NAG, r = -0.683, p = 0.04. The possibility that NAG could be a marker for serotonin metabolism is discussed.
D000118:Acetylglucosaminidase / Q000378:metabolism / Q000652:urine*; D000328:Adult; D001008:Anxiety Disorders / Q000523:psychology / Q000652:urine; D015415:Biomarkers; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales
D015415:Biomarkers; D006897:Hydroxyindoleacetic Acid; D000118:Acetylglucosaminidase