title: Non-neural-specific T lymphocytes can orchestrate inflammatory peripheral neuropathy.
abstract: Neural-specific T lymphocytes are held to play a pathological role in inflammatory peripheral nerve disorders such as the Guillain-Barré syndrome (GBS) and chronic inflammatory demyelinating polyneuropathy (CIDP). Here, non-neural-specific T-cell-mediated inflammation was studied in peripheral nerves in Lewis rats by systemic transfer of ovalbumin-specific activated T cells followed by intraneural injection of ovalbumin. Rapid endoneurial perivenular infiltration of alpha beta T cells and ED1+ macrophages occurred with ovalbumin injection following transfer of 2 x 10(6) T cells. This cellular infiltration and accumulation produced marked increases in blood-nerve barrier (BNB) permeability. In contrast, control casein injections produced neither significant cell accumulation nor BNB permeability changes. Transfer of a higher number of T cells (5 x 10(6)) induced severe Wallerian degeneration and nerve conduction failure in ovalbumin injected nerves. Fewer T cells (5 x 10(5)) induced conduction block and mild demyelination which were markedly augmented by systemic cotransfer of anti-myelin immunoglobulin. This study demonstrates that activated T cells of non-neural specificity can accumulate in peripheral nerve, produce dramatic changes in BNB permeability and with intravenous anti-myelin antibody orchestrate primary demyelination or axonal degeneration in a dose-dependent fashion.
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D004594:Electrophysiology; D005260:Female; D008213:Lymphocyte Activation; D009185:Myelin Proteins / Q000276:immunology; D009443:Neuritis / Q000276:immunology / Q000473:pathology*; D010047:Ovalbumin / Q000378:metabolism; D010523:Peripheral Nervous System Diseases / Q000276:immunology / Q000473:pathology; D011817:Rabbits; D051381:Rats; D011917:Rats, Inbred Lew; D013601:T-Lymphocytes / Q000276:immunology* / Q000378:metabolism; D013979:Tibial Nerve / Q000276:immunology / Q000473:pathology
chemical_list: D009185:Myelin Proteins; D010047:Ovalbumin