[An experimental validation of hyaluronidase electrophoresis for the prevention of postoperative adhesions].
The experiments on 50 animals were made to evaluate efficacy of electrophoresis of hyaluronidase (from actinohyal solution) against adhesions. Model abdominal adhesions in rats were exposed to hyaluronidase coming from anode and cathode for 20 min. There were altogether 10 daily procedures. The control animals received the solvent from the same poles or were not exposed to electrophoresis. The results demonstrate that hyaluronidase introduction from anode and cathode significantly decreases the occurrence and density of postoperative adhesions compared to controls.
D000818:Animals; D004353:Drug Evaluation, Preclinical; D006821:Hyaluronoglucosaminidase / Q000008:administration & dosage*; D007478:Iontophoresis; D007813:Laparotomy / Q000379:methods; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017208:Rats, Wistar; D012996:Solutions; D013997:Time Factors; D000267:Tissue Adhesions / Q000517:prevention & control
D012996:Solutions; D006821:Hyaluronoglucosaminidase
Eksperimental'noe obosnovanie élektroforeza gialuronidazy dlia profilaktiki posleoperatsionnykh spaek.