Molecular machinery of auditory and vestibular transduction.
The hunt for molecules that conduct mechanoelectrical transduction in hair cells has recently intensified. A hair cell's transduction apparatus adapts to sustained stimuli, and myosin I beta and myosin VIIA have been advanced as candidates for the motor that mediates this process. The identity of the transduction channel remains unknown, although a viable suggestion proposes that it belongs to the amiloride-sensitive Na+ channel family.
D000818:Animals; D006198:Hair Cells, Auditory / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D015398:Signal Transduction / Q000502:physiology*; D014722:Vestibule, Labyrinth / Q000378:metabolism / Q000502:physiology*