[Endogenous digitalis-like substance. I. Basic characteristics].
Endogenous digitalis-like substances (EDLS) present endogenous products which structurally belong to cardiac glycosides (CG). According contemporary views these substances potentially present a newly discovered hormonal group produced by adrenal cortex. EDLS, similarly exogenous CG, bind to specific CG- receptor of Na(+)-K(+)-ATPase and inhibit activity of this enzyme. At the cellular level, EDLS lead to increase in intracellular calcium storing and such may play an important role in modulation of calcium-dependent processes and their response to characteristic stimuli (e.g. contractility of vascular smooth muscle cells, hormonal secretion etc.). First part is a review of present views to character and cellular effects of EDLS.
D000818:Animals; D001798:Blood Proteins / Q000502:physiology*; D002298:Cardenolides; D004077:Digoxin; D004791:Enzyme Inhibitors / Q000378:metabolism*; D006801:Humans; D012503:Saponins; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors*
D001798:Blood Proteins; D002298:Cardenolides; D004791:Enzyme Inhibitors; D012503:Saponins; C034504:digoxin-like factors; D004077:Digoxin; D000254:Sodium-Potassium-Exchanging ATPase
Endogénne digitálisu podobné substancie. I. cast'--základné charakteristiky.