[Therapy of candiduria by alkalinization of urine. Oral treatment with potassium-sodium-hydrogen citrate].
METHODS
Eighteen hospitalized patients with candiduria were treated with oral potassium-sodium-hydrogen citrate to alkalinize the urine. The results obtained were compared with those observed in an untreated retrospective control group. Dosage was adjusted in accordance with the pH of the urine measured immediately before treatment with the aim of achieving a pH of 7 to 7.5.


RESULTS
All patients had an indwelling catheter, which is a predisposing factor for candiduria. In 16 out of 18 patients (89%) treatment with potassium-sodium-hydrogen citrate raised pH and resulted in the disappearance of candiduria. Duration of treatment varied between two days and one month (mean: seven days). In four patients the urine became completely sterile; during treatment 12 out of 18 patients developed significant bacteriuria (in eight cases of these the indwelling catheter had been left in place).


CONCLUSIONS
Alkalinization of the urine is a simple and effective method of treating candiduria in patients with an indwelling catheter. An additional advantage is the metaphylaxis and prophylaxis of renal stone formation in immobilized patients.
D000136:Acid-Base Equilibrium / Q000187:drug effects*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000863:Antacids / Q000008:administration & dosage*; D002177:Candidiasis / Q000188:drug therapy* / Q000652:urine; D002951:Citrates / Q000008:administration & dosage*; D019343:Citric Acid; D003428:Cross Infection / Q000188:drug therapy* / Q000652:urine; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D014546:Urinary Catheterization; D014552:Urinary Tract Infections / Q000188:drug therapy* / Q000652:urine; D014556:Urine / Q000382:microbiology*
D000863:Antacids; D002951:Citrates; D019343:Citric Acid
Therapie der Candidurie durch Alkalisierung des Harns. Orale Behandlung mit Kalium-Natrium-Hydrogencitrat.