[Dynamics of morphologic changes during treatment of experimental acute pancreatitis with 5-fluorouracil and intralipid].
In experimental pancreatitis induced by the modified Agai technique, the combined administration of 5-fluorouracil and intralipid produced an appreciable therapeutic effect, preventing the development of acinus necrosis and suppurative melting of the gland tissue. It is suggested that the effect of the pharmacological combination is consequent on the inhibitory action of 5-fluorouracil on DNA and RNA synthesis by exocrine cells of the pancreas and on the stabilizing action on the cellular and capillary membranes of unsaturated fatty acids constituting intralipid.
D000208:Acute Disease; D000818:Animals; D004359:Drug Therapy, Combination; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D005472:Fluorouracil / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D010179:Pancreas / Q000473:pathology*; D010195:Pancreatitis / Q000188:drug therapy* / Q000473:pathology; D051381:Rats
D005217:Fat Emulsions, Intravenous; D005472:Fluorouracil
Dinamika morfologicheskikh izmeneniĭ pri terapii éksperimental'nogo ostrogo pankreatita 5-ftoruratsilom i intralipidom.