Plasminogen activators and plasminogen activator inhibitor before and after surgery in patients with and without gastric malignancy.
Pre- and postoperative plasma levels of tissue-type plasminogen activator (t-PA), single-chain urinary plasminogen activator, and plasminogen activator inhibitor 1 (PAI-1) were measured in 40 patients undergoing gastric surgery in order to compare patients operated for benign (n = 21) and malignant (n = 19) disease. On the 1st postoperative day, the PAI-1 activity was significantly increased and the t-PA activity significantly decreased in the malignant group, whereas only insignificant changes were seen in the benign group. In contrast, the t-PA activity was significantly increased 1 week after surgery in patients without malignancy. In both groups, the single-chain urinary plasminogen activator activity decreased on the 1st postoperative day, but was significantly increased 1 month after operation. Thus, the two groups reacted differently, but it remains to be determined whether this bears any relationship to the well-known high risk of postoperative venous thromboembolism in cancer patients.
D000328:Adult; D000368:Aged; D001803:Blood Transfusion; D004198:Disease Susceptibility / Q000097:blood; D005260:Female; D005743:Gastrectomy; D005763:Gastroenterostomy; D006801:Humans; D008297:Male; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000032:analysis*; D010960:Plasminogen Activators / Q000032:analysis*; D011183:Postoperative Complications / Q000097:blood / Q000453:epidemiology*; D011184:Postoperative Period; D011446:Prospective Studies; D012307:Risk Factors; D013272:Stomach Diseases / Q000097:blood* / Q000601:surgery; D013274:Stomach Neoplasms / Q000097:blood* / Q000601:surgery; D013924:Thrombophlebitis / Q000097:blood / Q000453:epidemiology*; D010959:Tissue Plasminogen Activator / Q000032:analysis; D014568:Urokinase-Type Plasminogen Activator
D017395:Plasminogen Activator Inhibitor 1; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator