Somatotropin and somatostatin effects on vitamin K-dependent plasma coagulation factors.
The effects of somatotropin (0.2 mg/kg body mass) and somatostatin (0.1 mg/kg body mass) on plasma coagulation factors II, VII, IX, X and some general indexes of hemocoagulation were examined. Hormones were injected subcutaneously in male Wistar rats on 3 consecutive days. Boehringer Mannheim tests and Schnitger and Gross coagulometer were used for clotting factor determination. Somatotropin caused significantly decreased activity of factors II, VII and X (P < 0.001) and IX (P < 0.05). Somatostatin alone, as well as somatotropin after somatostatin pretreatment considerably increased the activity of factors II, VII and X (P < 0.001), while factor IX was non-significantly suppressed. It is concluded that somatotropin and somatostatin are possible regulators of biosynthesis of vitamin K-dependent plasma coagulation factors. Somatotropin depresses the activity of factors II, VII, IX and X and causes hypocoagulability, while somatostatin not only prevents the inhibiting effect on factors II, VII and X, but also increases their activity and causes hypercoagulability.
D000704:Analysis of Variance; D000818:Animals; D001777:Blood Coagulation / Q000187:drug effects; D001779:Blood Coagulation Factors / Q000187:drug effects*; D001800:Blood Specimen Collection; D004357:Drug Synergism; D005164:Factor IX / Q000187:drug effects; D005167:Factor VII / Q000187:drug effects; D005170:Factor X / Q000187:drug effects; D013006:Growth Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D007279:Injections, Subcutaneous; D008297:Male; D010314:Partial Thromboplastin Time; D011516:Prothrombin / Q000187:drug effects; D011517:Prothrombin Time; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000008:administration & dosage / Q000494:pharmacology*; D014812:Vitamin K / Q000494:pharmacology*
D001779:Blood Coagulation Factors; D014812:Vitamin K; D013004:Somatostatin; D005167:Factor VII; D011516:Prothrombin; D005164:Factor IX; D005170:Factor X; D013006:Growth Hormone