title: [The technology for manufacturing antiparasitic preparations. 4. The development of a technology for producing the anthelmintic bromoksan in finely dispersed form and the evaluation of its antifascioliasis activity].
abstract: A manufacturing procedure has been developed to prepare the anthelmintic bromoxane as a finely divided dosage form. The maximum toxic dose of the drug was 1 g per kg mice body weight. Its therapeutic dose in sheep fascioliasis was 20 mg/kg.
mesh_terms: D000818:Animals; D000980:Antiplatyhelmintic Agents / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D001549:Benzamides / Q000138:chemical synthesis* / Q000627:therapeutic use / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical / Q000662:veterinary; D005211:Fascioliasis / Q000188:drug therapy* / Q000662:veterinary; D051379:Mice; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy*; D013678:Technology, Pharmaceutical
chemical_list: D000980:Antiplatyhelmintic Agents; D001549:Benzamides
vernacular_title: Tekhnologiia proizvodstva protivoparazitarnykh preparatov. 4. Razrabotka tekhnologii polucheniia antigel'mintika bromoksana v melkodispersnoĭ forme i otsenka ego protivofastsioleznoĭ aktivnosti.