Structure-activity relationship of pamamycins: effects of alkyl substituents.
Nine new pamamycin homologues were isolated from the culture broth of Streptomyces alboniger IFO 12738 using a combination of ODS and NH2 HPLCs, and their structures determined by GC-MS. The structural differences in these homologues are in the numbers and positions of methyl and ethyl groups. The aerial mycelium-inducing and growth-inhibitory activities in S. alboniger of these homologues and their antibiotic activity against Bacillus subtilis were examined. The effects of the alkyl substituents on these activities are discussed.
D000935:Antifungal Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D008401:Gas Chromatography-Mass Spectrometry; D018942:Macrolides; D008826:Microbial Sensitivity Tests; D009930:Organic Chemicals; D013302:Streptomyces; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D018942:Macrolides; D009930:Organic Chemicals; C024500:pamamycin