Ketoacidosis-onset noninsulin dependent diabetes in Japanese subjects.
In 5 patients (2 women and 3 men, aged 16-36 years), diabetic ketoacidosis developed without precipitating illness. Pancreatic islet cell antibody was negative, and the duration of insulin dependency was shorter than 4 weeks. Hemoglobin A1c was < or = 6.3% for the mean period of 2.8 years thereafter, with diet therapy alone in 4 and with 5 mg glyburide in 1. Four were overweight before the development of diabetes, and 3 of them positive for family history of adult-onset, non-ketotic diabetes. Frequency of human leukocyte antigen B61 was increased significantly in the patients. In a patient not previously overweight, family history of diabetes was negative, and human leukocyte antigen haplotypes common in insulin-dependent diabetes mellitus were accumulated. Serum immunoreactive insulin was within normal range or supranormal with normal glucose tolerance after recovery. The patients closely resemble black Americans with ketoacidosis-onset non-insulin dependent diabetes.
D000293:Adolescent; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001835:Body Weight; D003924:Diabetes Mellitus, Type 2 / Q000175:diagnosis* / Q000628:therapy; D016883:Diabetic Ketoacidosis / Q000175:diagnosis* / Q000628:therapy; D004035:Diet Therapy; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006680:HLA Antigens / Q000032:analysis; D015235:HLA-B Antigens / Q000032:analysis; D006239:Haplotypes / Q000276:immunology; D006801:Humans; D007328:Insulin / Q000008:administration & dosage / Q000097:blood; D007564:Japan; D008297:Male; D013453:Sulfonylurea Compounds / Q000008:administration & dosage / Q000494:pharmacology
D001786:Blood Glucose; D006442:Glycated Hemoglobin; D006680:HLA Antigens; D015235:HLA-B Antigens; D007328:Insulin; D013453:Sulfonylurea Compounds; C079077:HLA-B61 antigen