Batrachotoxin induced axonal necrosis in peripheral nerves.
Batrachotoxin (BTX) depolarizes electrogenic membranes and also blocks axonal transport. We demonstrate that when applied in doses sufficient to block impulse transmission and axonal transport, BTX induces axonal necorsis. It is postulated that axonal necrosis is secondary to influx of sodium ions and water.
D000818:Animals; D001369:Axons / Q000187:drug effects*; D001496:Batrachotoxins / Q000494:pharmacology*; D008297:Male; D051379:Mice; D009186:Myelin Sheath / Q000187:drug effects; D009336:Necrosis; D009412:Nerve Fibers / Q000187:drug effects; D010543:Peroneal Nerve / Q000187:drug effects; D051381:Rats
D001496:Batrachotoxins