title: Local skin reaction in mice and guinea pigs induced by a single intradermal inoculation of Fusobacterium necrophorum lipopolysaccharide.
abstract: Dermal responses induced by Fusobacterium necrophorum strain VPI 2891 lipopolysaccharide (LPS) were studied using mice and guinea pigs. In ddY mice, the LPS elicited inflammatory, haemorrhagic lesions and an increase in local vascular permeability 24 h postinjection. Of the mouse strains, C3H/HeJ mice were less sensitive. The LPS induced erythema and haemorrhagic responses in guinea pig skin 24 h postinoculation. These responses were dose-dependent. The intensity of dermal inflammation-inducing activity of F. necrophorum LPS was similar to that of Escherichia coli strain 055:B5 LPS, but weaker than that of Salmonella typhimurium LPS. These findings suggest that the fusobacterial LPS may play an important role in contributing to produce the initial lesions in the bacterial infection.
mesh_terms: D000818:Animals; D004305:Dose-Response Relationship, Drug; D004890:Erythema / Q000139:chemically induced; D004926:Escherichia coli / Q000378:metabolism; D005675:Fusobacterium necrophorum; D006168:Guinea Pigs; D006470:Hemorrhage / Q000139:chemically induced; D007249:Inflammation / Q000139:chemically induced; D007271:Injections, Intradermal; D008070:Lipopolysaccharides / Q000494:pharmacology*; D051379:Mice; D008809:Mice, Inbred C3H; D008813:Mice, Inbred ICR; D012486:Salmonella typhimurium / Q000378:metabolism; D012867:Skin / Q000187:drug effects* / Q000473:pathology
chemical_list: D008070:Lipopolysaccharides