Does bacitracin have an absorption-enhancing effect in the intestine?
We studied the absorption enhancement effects of three types of protease inhibitors, aprotinin, bacitracin and soybean trypsin inhibitor, in the rat intestine. Of these protease inhibitors, bacitracin enhanced the absorption of FD-4 and phenol red from the rat small and large intestine without mucosal toxicity. Thus, it was suggested that bacitracin has not only a protease-inhibitory but also an absorption-enhancing capability.
D000818:Animals; D000955:Antigens, T-Independent; D001414:Bacitracin / Q000494:pharmacology* / Q000633:toxicity; D003911:Dextrans / Q000493:pharmacokinetics; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D007408:Intestinal Absorption / Q000187:drug effects*; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007420:Intestine, Large / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D008297:Male; D010637:Phenolsulfonphthalein / Q000493:pharmacokinetics; D011480:Protease Inhibitors / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D013050:Spectrometry, Fluorescence; D013268:Stimulation, Chemical
D000955:Antigens, T-Independent; D003911:Dextrans; D011480:Protease Inhibitors; C015219:fluorescein isothiocyanate dextran; D001414:Bacitracin; D016650:Fluorescein-5-isothiocyanate; D010637:Phenolsulfonphthalein