title: [The treatment of nephrotic-type chronic glomerulonephritis with Sandimmun (cyclosporin A)].
abstract: Sandimmun (ciclosporin A) treatment of chronic glomerulonephritis with nephrotic syndrome in a dose 2.5-5 mg/kg for 6-10 months relieved nephrotic syndrome in 2 and resulted in clinical improvement in other 2 of 4 patients treated. In 3 cases the patients failed previous therapy with high-dose corticosteroids and cytostatics. The drug reduced proteinuria, elevated serum levels of albumin and total protein, had low nephrotoxicity.
mesh_terms: D000328:Adult; D002908:Chronic Disease; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D005921:Glomerulonephritis / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use*; D008297:Male; D009404:Nephrotic Syndrome / Q000188:drug therapy*; D012074:Remission Induction; D013997:Time Factors
chemical_list: D007166:Immunosuppressive Agents; D016572:Cyclosporine
vernacular_title: Lechenie khronicheskogo glomerulonefrita nefroticheskogo tipa sandimmunom (tsiklosporinom A).