title: Regulated expression of the neural cell adhesion molecule L1 by specific patterns of neural impulses.
abstract: Development of the mammalian nervous system is regulated by neural impulse activity, but the molecular mechanisms are not well understood. If cell recognition molecules [for example, L1 and the neural cell adhesion molecule (NCAM)] were influenced by specific patterns of impulse activity, cell-cell interactions controlling nervous system structure could be regulated by nervous system function at critical stages of development. Low-frequency electrical pulses delivered to mouse sensory neurons in culture (0.1 hertz for 5 days) down-regulated expression of L1 messenger RNA and protein (but not NCAM). Fasciculation of neurites, adhesion of neuroblastoma cells, and the number of Schwann cells on neurites was reduced after 0.1-hertz stimulation, but higher frequencies or stimulation after synaptogenesis were without effect.
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology; D002448:Cell Adhesion; D002478:Cells, Cultured; D015536:Down-Regulation; D004558:Electric Stimulation; D005727:Ganglia, Spinal / Q000166:cytology; D039841:Leukocyte L1 Antigen Complex; D051379:Mice; D009414:Nerve Growth Factors / Q000494:pharmacology; D019006:Neural Cell Adhesion Molecules / Q000096:biosynthesis* / Q000235:genetics; D016501:Neurites / Q000502:physiology; D009475:Neurons, Afferent / Q000378:metabolism* / Q000502:physiology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D012583:Schwann Cells / Q000502:physiology; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology; D014407:Tumor Cells, Cultured
chemical_list: D039841:Leukocyte L1 Antigen Complex; D009414:Nerve Growth Factors; D019006:Neural Cell Adhesion Molecules; D012333:RNA, Messenger