title: [The mechanisms of synaptic plasticity: the role of synaptic protein phosphorylation and gene expression].
abstract: Results of investigations of protein phosphorylation and gene expression in the mechanisms of long-term potentiation and kindling was analyzed. It was discussed the participation of N-methyl-D-aspartate receptors, intracellular Ca2+, different protein kinases and immediate-early genes in the induction and maintenance of long-term changes of glutamatergic synaptic efficiency in hippocampus. It was suggested the essential role of the level of intracellular Ca2+ in the induction of the cell program leaded to the trace processes during electrical stimulation of the same hippocampal area.
mesh_terms: D000818:Animals; D004827:Epilepsy / Q000503:physiopathology; D005786:Gene Expression Regulation / Q000502:physiology*; D017774:Long-Term Potentiation / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009473:Neuronal Plasticity / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D010766:Phosphorylation; D013569:Synapses / Q000502:physiology*
chemical_list: D009419:Nerve Tissue Proteins
vernacular_title: Mekhanizmy sinapticheskoĭ plastichnosti: rol' fosforilirovaniia sinapticheskikh belkov i ékspressii genov.