[The anticlastogenic effect of ascorbic acid in relation to the damages induced in human lymphocytes by the photomutagenic action of 8-methoxypsoralen and by ammonium molybdate].
In experiments with cultured human lymphocytes anticlastogenic effect of ascorbic acid (AA) with respect to photomutagenic action of 8-methoxypsoralen (8-MOP) and ammonium molibdenate (Mo) was studied. It was found that AA effectively protected from mutagenic action of Mo. Effective protection of cells from 8-MOP monoadducts and DNA interstrand links was also observed.
D015112:4-Nitroquinoline-1-oxide / Q000494:pharmacology; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000494:pharmacology*; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004247:DNA / Q000187:drug effects / Q000528:radiation effects; D004249:DNA Damage; D004260:DNA Repair / Q000187:drug effects; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000528:radiation effects; D008730:Methoxsalen / Q000494:pharmacology*; D008982:Molybdenum / Q000494:pharmacology*; D009153:Mutagens / Q000494:pharmacology*; D017319:Photosensitizing Agents / Q000494:pharmacology*; D013997:Time Factors; D014466:Ultraviolet Rays
D016587:Antimutagenic Agents; D009153:Mutagens; D017319:Photosensitizing Agents; D015112:4-Nitroquinoline-1-oxide; D008982:Molybdenum; D004247:DNA; C022175:ammonium molybdate; D001205:Ascorbic Acid; D008730:Methoxsalen
Izuchenie antiklastogennogo éffekta askorbinovoĭ kisloty po otnosheniiu k povrezhdeniiam, indutsirovannym v limfotsitakh cheloveka fotomutagennym deĭstviem 8-metoksipsoralena i molibdenatom ammoniia.