A barbiturate evoked intensification of postsynaptic inhibition in the preoptic ovulatory trigger region of the hypothalamus.
Extracellular single unit recordings were used to study inhibitory synaptic responses evoked from preoptic-anterior hypothalamic neurones following arcuate-ventromedial stimulation. Intravenously administered methohexitone, pentobarbitone and thiopentone increased the duration of inhibitory synaptic responses by up to 400%. Submaximal responses to iontophoretically applied GABA but not glycine were also potentiated. Recovery from the actions of the short acting barbiturates was observed.
D000818:Animals; D001463:Barbiturates / Q000494:pharmacology*; D005260:Female; D007031:Hypothalamus / Q000187:drug effects*; D008723:Methohexital / Q000494:pharmacology; D009433:Neural Inhibition / Q000187:drug effects*; D009474:Neurons / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D010424:Pentobarbital / Q000494:pharmacology; D011301:Preoptic Area / Q000187:drug effects*; D051381:Rats; D013569:Synapses / Q000187:drug effects; D013874:Thiopental / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D001463:Barbiturates; D005680:gamma-Aminobutyric Acid; D008723:Methohexital; D010424:Pentobarbital; D013874:Thiopental