[Idiopathic ductopenia of adulthood: favorable effect of ursodeoxycholic acid therapy].
A 59-year-old woman presented with chronic, clinically asymptomatic cholestasis. Idiopathic adulthood ductopenia was diagnosed on the basis of clinical, laboratory and morphological findings. A retrograde cholangiographic study demonstrated intact large bile ducts with an apparent reduction of the small caliber intrahepatic ducts. The patient was treated with ursodeoxycholic acid (dosage 750 mg/day) which led to a decrease of alkaline phosphatase and Y-GT levels (before therapy: AP ca. 650 U/l; Y-GT ca. 150 U/l; after 6 month of treatment: AP ca. 350 and Y-GT ca. 30 U/l), suggesting, that the drug might be efficacious.
D001653:Bile Ducts, Intrahepatic / Q000473:pathology; D001706:Biopsy; D002758:Cholangiography; D002780:Cholestasis, Intrahepatic / Q000188:drug therapy* / Q000209:etiology / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D008875:Middle Aged; D016896:Treatment Outcome; D014580:Ursodeoxycholic Acid / Q000627:therapeutic use*
D014580:Ursodeoxycholic Acid
Idiopathische Duktopenie des Erwachsenenalters: günstiger Effekt einer Ursodesoxycholsäure-Therapie.