title: Responsiveness of equine basilar artery to transmural nerve stimulation differs from that of porcine and bovine basilar arteries in vitro.
abstract: Transmural nerve stimulation (TNS) induced relaxations in porcine and bovine basilar arteries which were abolished by tetrodotoxin (TTX) and by L-nitro-arginine (LNAG). However, TNS induced contractions in equine basilar artery which were abolished by TTX and by guanethidine, but not by LNAG. These results suggest that the TNS-induced contractions of equine basilar arteries may be mediated by norepinephrine release.
mesh_terms: D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001488:Basilar Artery / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D002417:Cattle / Q000502:physiology*; D015237:Dinoprost / Q000494:pharmacology; D004558:Electric Stimulation; D004730:Endothelium, Vascular / Q000502:physiology; D006145:Guanethidine / Q000494:pharmacology; D006736:Horses / Q000502:physiology*; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000294:innervation* / Q000502:physiology; D019335:Nitroarginine; D011189:Potassium Chloride / Q000494:pharmacology; D013045:Species Specificity; D013552:Swine / Q000502:physiology*; D013779:Tetrodotoxin / Q000494:pharmacology
chemical_list: D019335:Nitroarginine; D013779:Tetrodotoxin; D011189:Potassium Chloride; D001120:Arginine; D015237:Dinoprost; D006145:Guanethidine