Neonatal soft tissue sarcomas: the influence of pathology on treatment and survival. Children's Cancer Group Surgical Committee.
BACKGROUND
A multi-institutional study was conducted by the Children's Cancer Group (CCG) to evaluate all soft tissue sarcomas diagnosed within the first month of life.


METHODS
A retrospective study by 11 CCG institutions of patient records from 1971 to 1991 were reviewed for demographic data, pathology, therapy, and outcome.


RESULTS
32 neonates with soft tissue sarcomas were identified. There were 21 boys and 11 girls. Pathology was equally divided into three groups: Congenital fibrosarcoma (CFS) (12), rhabdomyosarcoma (RMS) (11), and non-RMS soft tissue sarcomas (NRSTS) (9). Anatomic sites consisted of head/neck (11), extremity (9), trunk (8), pelvis (3), and unknown (2). Overall survival rate was 59% (19/32).


CONCLUSIONS
Soft tissue sarcomas in the neonate comprise three general groups with survival rates dependent on pathology and extent of disease.
D003131:Combined Modality Therapy; D005121:Extremities; D005260:Female; D005354:Fibrosarcoma / Q000151:congenital / Q000473:pathology / Q000601:surgery; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000151:congenital / Q000473:pathology / Q000601:surgery; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D010386:Pelvic Neoplasms / Q000151:congenital / Q000473:pathology / Q000601:surgery; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000151:congenital / Q000473:pathology / Q000601:surgery; D012509:Sarcoma / Q000151:congenital* / Q000473:pathology* / Q000601:surgery; D015996:Survival Rate; D013899:Thoracic Neoplasms / Q000151:congenital / Q000473:pathology / Q000601:surgery; D016896:Treatment Outcome