Resistance patterns to beta-lactams and quinolones in clinical isolates of bacteria from Cuban hospitals.
The resistance patterns to 26 beta-lactams and 8 quinolones of clinical isolates from Cuban hospitals were evaluated using the disk susceptibility test, according to the NCCLS guidelines (1992). The genera studied were Escherichia sp (320), Enterobacter sp (10), Klebsiella sp (90), Proteus sp (10), Pseudomonas sp (90), Serratia sp (20), and Staphylococcus sp (80). Higher resistance to beta-lactams was observed in the genera Pseudomonas, Escherichia and Klebsiella. For fluoroquinolones we found no significant resistance, with the exception of the genus Klebsiella. The most effective antibiotics were cephalosporins of the second and third generations, fluoroquinolones, and non-classical beta-lactams (cephamycins, moxalactam and monobactams). On the contrary, a pronounced resistance was found to penicillin, oxacillin, ticarcillin, ampicillin, methicillin, nalidixic acid and cinoxacin. These resistance patterns correspond to the high consumption of these antibiotics throughout the country.
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000494:pharmacology*; D018550:Cephalosporin Resistance; D003428:Cross Infection / Q000453:epidemiology / Q000382:microbiology*; D003462:Cuba / Q000453:epidemiology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006801:Humans; D008826:Microbial Sensitivity Tests; D010403:Penicillin Resistance; D018440:beta-Lactam Resistance
D042462:4-Quinolones; D000890:Anti-Infective Agents