[The effect of subgingival irrigation with acetylsalicylate on the polymorphonuclear leukocyte count in periodontal pockets of medium depth].
Considering the role played by arachidonic acid metabolites in the pathogenesis of periodontal disease and the possible beneficial effects exerted by non steroidal anti inflammatory drugs on periodontal damage, the aim of the present study was to assess the capability of a 1% acetylsalicylate solution, delivered by subgingival irrigation, in reducing the number of polymorphonuclear leukocytes (PMN) in periodontal pockets of patients affected by periodontitis. Ten patients systemically healthy, in the age between 36 and 64, participated in the study. After supragingival scaling in each patient test and two control sites were chosen among those exhibiting a pocket depth between 5 and 7 mm. The number of periodontal pocket PMN was evaluated after subgingival washing by the technique of Skapski & Lenher and Gingival Bleeding Index (GBI) score was recorded in each experimental site. Test sites then received subgingival subgingival washing by 0.5 ml of a 1% acetylsalicylate solution three times a week whereas control sites were irrigated by physiologic solution. After treatment the number of PMN and GBI scores from each test and control site was re-evaluated. Results showed that test sites exhibited a decrease in the number of pocket-PMN respect to control sites although not statistically significant (p > 0.5). At contrary GBI score did not modify through the study. In conclusion subgingival irrigation by acetylsalicylate demonstrated to be able to reduce subclinical inflammation in periodontal pockets evaluated by the number of PMN in gingival fluid.
D000328:Adult; D001241:Aspirin / Q000008:administration & dosage*; D016009:Chi-Square Distribution; D004341:Drug Evaluation; D005260:Female; D005881:Gingiva; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects*; D010512:Periodontal Index; D010514:Periodontal Pocket / Q000188:drug therapy*; D012996:Solutions; D007507:Therapeutic Irrigation / Q000706:statistics & numerical data
D012996:Solutions; D001241:Aspirin
Effetto di irrigazioni subgengivali con acetilsalicilato sul numero di leucociti polimorfonucleati in tasche parodontali di media profondità.