Metabolic mismatch of septal beta-oxidation and glucose utilization in left bundle branch block assessed with PET.
Preserved septal uptake of the new long-chain fatty acid analog [18F]FTHA was found in a patient with three-vessel disease, a history of previous anterior myocardial infarction and left bundle branch block (LBBB), despite severely decreased septal [18F]FDG uptake that suggested scarred tissue. Nearly absent [19F]FDG uptake in the septum could not be explained by concordant reduction of septal perfusion as assessed by 99mTc-MIBI SPECT. These data may point to divergent metabolic effects of the conduction abnormality in LBBB with consecutively reduced septal exogenous glucose utilization but unaffected septal beta-oxidation.
D000368:Aged; D002037:Bundle-Branch Block / Q000000981:diagnostic imaging*; D003327:Coronary Disease / Q000000981:diagnostic imaging; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D005227:Fatty Acids; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D006321:Heart / Q000000981:diagnostic imaging*; D006346:Heart Septum; D006801:Humans; D008297:Male; D009206:Myocardium / Q000378:metabolism; D017256:Technetium Tc 99m Sestamibi; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon
D005227:Fatty Acids; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; C071178:14-fluoro-6-thiaheptadecanoic acid; D017256:Technetium Tc 99m Sestamibi; D003847:Deoxyglucose