The effects of dopamine and dobutamine on liver oxygen supply-uptake relationship in the dog.
The effects of dopamine and dobutamine in various doses on liver oxygen supply-uptake relationship were studied in 12 mongrel dogs. Dopamine 3 and 7 micrograms/kg/min infusion rates and dobutamine 5 micrograms/kg/min infusion rate did not produce any changes in total liver oxygen delivery. On the contrary, total liver oxygen delivery was increased at the 15 micrograms/kg/min dopamine in fusion rate and dobutamine 10 and 15 micrograms/kg/min infusion rates. The ratio of total liver oxygen delivery to the systemic oxygen delivery was increased at the 15 micrograms/kg/min dopamine infusion rate. Liver oxygen extraction ratio was decreased at the 15 micrograms/kg/min dopamine infusion rate and at the same rate of dobutamine. These decreases were due to the increases in oxygen delivery while both oxygen uptakes were avariant from control levels. The results of this study demonstrated that high dose of dopamine (15 micrograms/kg/min) and medium and high doses of dobutamine (10 and 15 micrograms/kg/min) should be useful to increase the liver oxygen delivery. However, these increases in liver oxygen delivery during dopamine and dobutamine infusion were not associated with an improvement in liver oxygen metabolism, since liver oxygen uptake was not changed.
D000818:Animals; D004280:Dobutamine / Q000008:administration & dosage / Q000494:pharmacology*; D004285:Dogs; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006499:Hepatic Artery / Q000502:physiology; D007262:Infusions, Intravenous; D008099:Liver / Q000187:drug effects / Q000378:metabolism*; D008102:Liver Circulation / Q000187:drug effects / Q000502:physiology*; D010100:Oxygen / Q000097:blood*; D010101:Oxygen Consumption / Q000187:drug effects*; D011169:Portal Vein / Q000502:physiology; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects
D004280:Dobutamine; D010100:Oxygen; D004298:Dopamine