Total synthesis of (+/-)-phosphonothrixin, a novel herbicidal antibiotic containing C-P bond.
Phosphonothrixin (1) is a novel herbicidal agent produced by Saccharothrix sp. ST-888, with a unique structure possessing a C-P bond and an isoprene unit. The total synthesis of this antibiotic was accomplished from methyl (bromomethyl)acrylate in six steps.
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis*; D006540:Herbicides / Q000138:chemical synthesis*; D063065:Organophosphonates / Q000138:chemical synthesis*; D013329:Structure-Activity Relationship
D000900:Anti-Bacterial Agents; D006540:Herbicides; D063065:Organophosphonates; C096940:phosphonothrixin