title: Effects of testosterone on tumor induction and epidermal growth factor production in the mouse submandibular gland.
abstract: To determine whether testosterone administration was capable of modifying salivary gland carcinogenesis, female mice were given 1 mg of 9,10-dimethyl-1,2-benzanthracene (DMBA) into the left submandibular gland and then Group 1 mice received 5 mg of testosterone propionate and Group 2 mice received vehicle, olive oil, subcutaneously for 8 weeks. Twelve weeks after the start of the experiment, the weight of the left submandibular gland of the Group 2 mice was greater than that of the Group 1 mice. The incidences of submandibular gland carcinoma in Groups 1 and 2 were 41% (12/29) and 57% (17/30), respectively. Epidermal growth factor (EGF) levels of the left submandibular gland were significantly higher in Group 1 as compared with Group 2. These findings indicate that testosterone increases the production of EGF in the DMBA-injected submandibular gland, but does not promote the development of submandibular gland carcinoma.
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000230:Adenocarcinoma / Q000139:chemically induced / Q000378:metabolism; D000818:Animals; D002277:Carcinoma / Q000139:chemically induced / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000378:metabolism; D004815:Epidermal Growth Factor / Q000096:biosynthesis*; D005260:Female; D051379:Mice; D009929:Organ Size / Q000187:drug effects; D013363:Submandibular Gland / Q000187:drug effects*; D013365:Submandibular Gland Neoplasms / Q000139:chemically induced / Q000378:metabolism*; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D013739:Testosterone; D015127:9,10-Dimethyl-1,2-benzanthracene; D004815:Epidermal Growth Factor