[Development of apoptosis induced by whole-body irradiation in murine liver].
Apoptosis is known to be induced by radiation. However, the correlation between radiation-induced apoptosis and radiation injury in tumors in vivo has been unclear. In this paper, we report the study of apoptosis induced by whole-body irradiation using an immunohistochemical technique to detect DNA fragmentation in murine liver. A dose of 7 Gy was employed as LD50/30. DNA fragmentation was observed 30 min after radiation, and it peaked between 1 and 6 hours. DNA fragmentation could be detected 48 hours after radiation in capillary endothelium. This study was able to reveal the development of radiation-induced apoptosis in the liver by detecting DNA fragmentation in situ.
D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D004247:DNA / Q000032:analysis; D005260:Female; D007150:Immunohistochemistry; D008099:Liver / Q000166:cytology / Q000528:radiation effects*; D051379:Mice; D008809:Mice, Inbred C3H; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D004247:DNA