COHb formation and acute carbon monoxide intoxication in adult male rats and guinea-pigs.
Respiratory exchange recordings and percentage survivals to lethal concentrations show that rats are more sensitive than guinea-pigs to an acute carbon monoxide intoxication. To avoid circadian respiratory an comportmental differences between rats and guinea-pigs experiments were performed on urethane anesthetized and artificially ventilated animals. This procedure demonstrates that, for an inhaled concentration of 0.05% CO, the rates of formation of COHb do not statistically differ in rats and in guinea-pigs, but that a higher (0.01 less than p less than 0.05) COHb saturation is reached in rats (35%) than in guinea-pigs (25%). For a 2.84% CO inhalation, no statistically significant difference is observed in the rate of COHb formation, but cardiac arrest is sooner (p less than 0.001) observed in rats than in guinea-pigs.
D000208:Acute Disease; D000777:Anesthetics; D000818:Animals; D002248:Carbon Monoxide / Q000097:blood*; D002249:Carbon Monoxide Poisoning / Q000503:physiopathology; D002263:Carboxyhemoglobin / Q000378:metabolism*; D002940:Circadian Rhythm; D006168:Guinea Pigs; D006454:Hemoglobins / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D051381:Rats; D012121:Respiration, Artificial; D014520:Urethane / Q000494:pharmacology; D014692:Ventilation-Perfusion Ratio
D000777:Anesthetics; D006454:Hemoglobins; D014520:Urethane; D002248:Carbon Monoxide; D002263:Carboxyhemoglobin