[The distribution of sleep and wakefulness in human African trypanosomiasis].
Last century, patients with human African trypanosomiasis were described as sleepy by day and restless by night, and physicians referred to this condition as sleeping sickness. Such a description could have evoked a disturbance of circadian rhythms. However, it is only in 1989 that the first 24-hour recording was performed by our team in Niamey (Niger) in a patient with sleeping sickness. The patient was a Niger-born farm worker who had contracted the disease near Gagnoa (Côte d'Ivoire). Polysomnographic recordings (electroencephalogram, EEG, electrooculogram, electromyogram, electrocardiogram, buccal and nasal airflow, and chest respiratory movements) showed a disappearance of the circadian distribution of sleep and wakefulness, which tended to occur evenly throughout day and night, with a sleep-wake alternation of approximately 80 minutes. Two investigations were conducted thereafter. The first one was done at Daloa (Côte d'Ivoire) in 8 patients who were recorded during two 24-hour periods, with and without hourly blood samples; the second at Brazzaville (Congo) in 10 patients recorded for 24 hours before and after treatment with melarsoprol. All patients were at the stage of early meningoencephalitis. At Daloa, polysomnographic recordings were taken on two 8-channel EEG machines (Alvar Minihuit, and T3-ECEM), as well as on a portable Oxford Medilog 9000 system from the same electrodes. Sleep and wake structure was altered in the most severely sick patient, the EEG trace being loaded with slow waves. Stages 1 and 2, and stages 3 and 4 could not be distinguished from one another. In the other patients, all sleep stages were easily scored. No difference was seen between recordings, regarding blood collection.(ABSTRACT TRUNCATED AT 250 WORDS)
D002940:Circadian Rhythm / Q000187:drug effects; D003223:Congo; D007560:Cote d'Ivoire; D004562:Electrocardiography; D004569:Electroencephalography; D006801:Humans; D008549:Melarsoprol / Q000627:therapeutic use; D008590:Meningoencephalitis / Q000188:drug therapy / Q000469:parasitology; D009548:Niger; D017286:Polysomnography; D011595:Psychomotor Agitation / Q000503:physiopathology; D012123:Pulmonary Ventilation / Q000502:physiology; D015656:Respiratory Mechanics / Q000502:physiology; D012890:Sleep / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors; D014353:Trypanosomiasis, African / Q000097:blood / Q000188:drug therapy / Q000503:physiopathology*; D014851:Wakefulness / Q000187:drug effects / Q000502:physiology*
D008549:Melarsoprol
Distribution du sommeil et de la veille dans la trypanosomose humaine africaine.