[The role of the individual subtypes of the brain adreno- and dopaminergic receptors in regulating the function of the hypothalamo-hypophyseal-testicular system].
Activation of different subtypes of adrenergic (AR) and dopamine receptors (DR) and its effect on the blood testosterone level, were studied. Intraventricular administration of selective agonists mesatone and clonedine as well as dobutamine increased the testosterone level in the blood, where as clenbuterol exerted no such effect. Activation of D1-DR by SKF 38393 in ZI and PVGM elevated the testosterone level as well. Activation of D2-DR by LY 171555 in ZI exerted no effect and in the PVGM even inhibited the testosterone level.
D000322:Adrenergic Agonists / Q000494:pharmacology; D018674:Adrenergic Antagonists / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000502:physiology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011941:Receptors, Adrenergic / Q000187:drug effects / Q000502:physiology*; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology*; D013737:Testis / Q000187:drug effects / Q000502:physiology*; D013739:Testosterone / Q000097:blood
D000322:Adrenergic Agonists; D018674:Adrenergic Antagonists; D011941:Receptors, Adrenergic; D011954:Receptors, Dopamine; D013739:Testosterone
Rol' otdel'nykh podtipov adreno- i dofaminovykh retseptorov golovnogo mozga v reguliatsii funktsii gipotalamo-gipofizarno-semennikovogo kompleksa.