title: Susceptibility of Acanthamoeba castellanii to contact lens disinfecting solutions.
abstract: A corneal isolate of Acanthamoeba castellanii was exposed to commercial contact lens disinfecting solutions containing hydrogen peroxide, benzalkonium chloride, polyaminopropyl biguanide, polyquaternium 1, and chlorhexidine-thimerosal. The minimum trophozoite amebicidal concentration and exposure times required to kill trophozoites and cysts were determined. Solutions containing hydrogen peroxide or chlorhexidine-thimerosal were active against both trophozoites and cysts. The benzalkonium chloride-based solution was effective only against trophozoites. Solutions containing polyaminopropyl biguanide or polyquaternium 1 were completely ineffective. The need for adequate exposure times must be stressed.
mesh_terms: D000048:Acanthamoeba / Q000187:drug effects*; D000818:Animals; D018639:Contact Lens Solutions / Q000494:pharmacology*; D007700:Kinetics; D008826:Microbial Sensitivity Tests
chemical_list: D018639:Contact Lens Solutions