title: Ischemic stroke following an intramuscular injection of diclofenac. Case report.
abstract: Nonsteroidal antiinflammatory drugs (NSAIDs) have arterial vasospastic properties. The authors report a stroke that occurred within minutes following an intramuscular injection of diclofenac. A sixty-one-year-old man, a heavy smoker, was admitted for an acute onset of mild hemiparesis thirty minutes after a single intramuscular injection of diclofenac. The neurologic deficit was resolved at one month of follow-up. The authors suggest a temporal causal relationship between the cerebrovascular event and the injection of diclofenac. The mechanism of stroke might be related to a synergistic vasospastic property shared by the use of an NSAID and heavy smoking.
mesh_terms: D000208:Acute Disease; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000009:adverse effects*; D002545:Brain Ischemia / Q000139:chemically induced* / Q000175:diagnosis; D004008:Diclofenac / Q000008:administration & dosage / Q000009:adverse effects*; D006429:Hemiplegia / Q000139:chemically induced / Q000175:diagnosis; D006801:Humans; D007273:Injections, Intramuscular; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000009:adverse effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D004008:Diclofenac