Effects of endoscopic variceal ligation in lower esophageal motor function: a prospective study.
OBJECTIVE
Endoscopic variceal ligation (EVL), a recently developed method for controlling active variceal bleeding and eradicating esophageal varices, has similar efficacy to endoscopic injection sclerotherapy (EIS) and is known to have a minimal risk of complications and fewer complications in the lower esophagus. However, since the site of EVL is chiefly done in the lower esophagus, we prospectively evaluated to investigate the effect of EVL on the lower esophageal motor function.


METHODS
We evaluated the severity of esophageal varix with the endoscopy and the lower esophageal manometry in 27 patients who had no history of interventional therapy, for varices before EVL, 3 weeks and 6 months after the last EVL session.


RESULTS
The EVL caused considerable diminution in the size of esophageal varix by a mean 8.2 (range 3-21) ligations in mean 1.7 (range 1-3) sessions. In most of the cases, the varices reappeared and enlarged when the procedure of EVL was stopped. There were two different types of changes (intermediate and late) in the lower esophageal motility. The intermediate post-EVL effects were the increase of peristaltic contraction amplitude and duration in the lower esophageal body after EVL. The late post-EVL effects were the prolongation of lower esophageal sphinctor (LES) relaxation duration and speedier peristaltic velocity in the lower esophageal body.


CONCLUSIONS
We conclude from these findings that the intermediate post-EVL effect may be transient and the increase of peristaltic wave was due to diminution of esophageal varix.
D000328:Adult; D000368:Aged; D016099:Endoscopy, Gastrointestinal; D015154:Esophageal Motility Disorders / Q000209:etiology; D004932:Esophageal and Gastric Varices / Q000503:physiopathology / Q000628:therapy*; D004947:Esophagus / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008026:Ligation; D008297:Male; D008365:Manometry; D008875:Middle Aged; D011446:Prospective Studies