A sequence analysis of human germline Ig VH and VL genes. The CDR1s of a major proportion of VH, but not VL, genes display a high inherent susceptibility to amino acid replacement.
D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D003062:Codon; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D009154:Mutation; D017385:Sequence Homology
D003062:Codon; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region