Levels of flurithromycin in female genital tissue.
The levels of flurithromycin in gynecological tissue in 20 female patients were studied after preoperative administration. The tissue flurithromycin levels obtained were comparable to those obtained in serum at 3 and 4 h but were frequently higher than those in serum at 6 and 12 h. Flurithromycin reached the highest concentrations in ovary at 4 h and in endometrium at 6 h.
D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D001681:Biological Assay; D004917:Erythromycin / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D005260:Female; D005836:Genitalia, Female / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D016982:Micrococcus luteus / Q000187:drug effects
D000900:Anti-Bacterial Agents; C045925:flurithromycin; D004917:Erythromycin