[The morphofunctional changes in the ventricular myocardium in experimental infarct and its treatment by hyperbaric oxygenation and tocopherol acetate].
Experimental myocardial infarction was induced in 50 rabbits, 25 of which were subjected to hyperbaric oxygenation (HBO) used as a single procedure or in combination with the antioxidant tocopheroli acetas. HBO was found to promote reduction of the myocardial lesion focus and enhancement of the regeneration processes but in everyday employment over long periods of time it causes dystrophic changes in the remote zones of the myocardium. Administration of tocopheroli acetas before the HBO sessions allows the toxic action of oxygen to be safely prevented.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D006321:Heart / Q000503:physiopathology*; D006352:Heart Ventricles / Q000503:physiopathology; D006651:Histocytochemistry; D006931:Hyperbaric Oxygenation; D008297:Male; D008854:Microscopy, Electron; D009203:Myocardial Infarction / Q000503:physiopathology / Q000628:therapy*; D009206:Myocardium / Q000201:enzymology / Q000648:ultrastructure; D011817:Rabbits; D013385:Succinate Dehydrogenase / Q000378:metabolism; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000975:Antioxidants; D014810:Vitamin E; D013385:Succinate Dehydrogenase; D024502:alpha-Tocopherol; D024505:Tocopherols
Morfofunktsional'ni zminy miokarda shlunochkiv pry eksperymental'nomu infarkti ta ĭoho likuvanni hiperbarychnoiu oksyhenatsiieiu i tokoferolu atsetatom.