Efficacy of a spring strategic fenbendazole treatment program to reduce numbers of Ostertagia ostertagi inhibited larvae in beef stocker cattle.
Efficacy of a spring strategic treatment program with fenbendazole (FBZ) to reduce the accumulation of Ostertagia ostertagi inhibited early fourth-stage larvae (EL4) was investigated in two groups of crossbred beef heifers which were 7-9 months of age and ranged in weight from 155 to 223 kg. The cattle were allocated to groups and treated on 27 April (Day 0). Group 1 calves served as nontreated controls. Group 2 calves were treated with FBZ 10% drench suspension at 5 mg kg-1 on Day 0 and with 6-day courses of FBZ free-choice mineral (to provide 5 mg kg-1 per animal) on Days 28 and 56. Each group grazed on a separate 4.9 ha pasture for 105 days to 10 August. On 10 August the cattle were taken off pasture and each original group was re-allocated to subgroups of three cattle which were treated orally with FBZ (5 mg kg-1), oxfenbendazole (OXF, 4.5 mg kg-1) or left nontreated (CONT). The cattle were necropsied on Days 120 and 121. Mean actual and cumulative fecal egg counts indicated near total suppression of egg output in the strategically treated group (high of 5.2 eggs g-1 feces (EPG) on Day 28). Egg counts of the nontreated group remained above 100 or 200 EPG to Day 63 and then decreased to less than 100. Ostertagia was the predominant genus, followed by Cooperia on most sampling dates. The largest O. ostertagi worm burdens were recovered from the CONT-CONT subgroup; numbers of EL4 ranged from 18,922 to 51,137. Reduction in numbers of EL4 in original controls, treated with FBZ or OXF in August, were low, being 60.2% and 74.3%, respectively. The numbers of O. ostertagi recovered from subgroups originally treated strategically with FBZ were generally lower than in original controls. The largest reduction in O. ostertagi numbers was in the FBZ-CONT subgroup, which was not treated in August. Percent reduction values for O. ostertagi adults, developing L4 (DL4) and EL4 were 84.6%, 96.7%, and 99.0%, respectively. Percent reduction values for adults, DL4 and EL4 in the FBZ-FBZ and FBZ-OXF subgroups were 90.7%, 61.3%, 85.6% and 92.4%, 45.5%, and 73.0%, respectively. Variability in numbers of EL4 acquired during grazing by original controls and strategically treated cattle and variability in efficacy of August treatments was evident as observed in high outlier numbers of worms in all subgroups except the FBZ-CONT subgroup. Liveweights and gains were nearly identical in the two groups on 10 August.
D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D002417:Cattle; D002418:Cattle Diseases; D005243:Feces / Q000469:parasitology; D005260:Female; D005273:Fenbendazole / Q000627:therapeutic use*; D007814:Larva; D008460:Meat; D010028:Ostertagia / Q000254:growth & development / Q000302:isolation & purification*; D010029:Ostertagiasis / Q000517:prevention & control / Q000662:veterinary*; D010270:Parasite Egg Count; D012621:Seasons
D000969:Antinematodal Agents; D005273:Fenbendazole