Radiotherapy for thyroid orbitopathy. Effects on extraocular muscle balance.
OBJECTIVE
To investigate the effects of radiotherapy on the restrictive ophthalmopathy and strabismus that occur with Graves' orbitopathy.


METHODS
A prospective study of patients with motility disturbances due to thyroid orbitopathy, followed by serial quantitative measurements of ocular restrictions and deviations, both before and at 1 and 6 months after treatment with high-energy radiotherapy.


METHODS
Urban subspecialty private practice.


METHODS
Thirty-three consecutive patients with restricted extraocular movements and diplopia secondary to thyroid orbitopathy who were treated with radiotherapy were seen during an 8-year period.


METHODS
Maximal horizontal and vertical ductions, plus ocular deviations in primary and reading positions of gaze, were quantitatively evaluated by one clinical investigator to ensure consistency.


RESULTS
Statistically significant improvement in gaze restriction on supraduction and improvement of vertical and horizontal strabismus were demonstrated at follow-up visits after treatment.


CONCLUSIONS
Although statistically significant improvement of motility disturbances were demonstrated after radiotherapy, there was less than desirable functional improvement of restrictive ophthalmopathy and strabismus; thus the usefulness of radiotherapy was limited when it was used alone to treat diplopia.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004172:Diplopia / Q000209:etiology / Q000503:physiopathology / Q000532:radiotherapy; D005133:Eye Movements; D005260:Female; D006111:Graves Disease / Q000150:complications / Q000503:physiopathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D015835:Ocular Motility Disorders / Q000209:etiology / Q000503:physiopathology / Q000532:radiotherapy*; D009801:Oculomotor Muscles / Q000502:physiology*; D011446:Prospective Studies