[Is treatment with corticotherapy or radiotherapy effective for involvement of ocular motility and for reduction of exophthalmos in Basedow's disease?].
It is acknowledged that high-dose corticotherapy, radiotherapy, or surgical decompression of the orbit are often efficient in dysthyroid optic neuropathy. Corticotherapy and radiotherapy are also given to patients with dysfunction of eye-muscle motility and/or proptosis in the absence of visual loss. The latter indication has been retrospectively evaluated in 13 patients. The limited character of our series is partially explainable by strict inclusion criteria (objective evaluation of muscle dysfunction and proptosis). We failed to demonstrate any significant functional improvement after oral corticotherapy and/or radiotherapy. It thus appears that our study sheds doubt on the actual efficacy of these treatments in patients presenting with not very evolutive involvement of eye-muscle motility. A larger study aimed at comparing the benefits and drawbacks of these treatments is consequently to be encouraged.
D000328:Adult; D000368:Aged; D005094:Exophthalmos / Q000188:drug therapy* / Q000532:radiotherapy; D005133:Eye Movements / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D006111:Graves Disease / Q000188:drug therapy* / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use*; D008875:Middle Aged; D011879:Radiotherapy Dosage; D012189:Retrospective Studies; D017211:Treatment Failure
D008775:Methylprednisolone
Le traitement par corticothérapie ou radiotherapie est-il efficace pour l'atteinte de la motilité oculaire et pour la réducion de l'exophtalme dans la maladie de Basedow?