Vasoactive effects of aqueous extracts from five Mexican medicinal plants on isolated rat aorta.
The present investigation describes the effects of aqueous extracts from Chiranthodendron pentadactylon flowers, Galphimia glauca leaves and flowers, Ipomoea stans roots, Juglans regia leaves and Taxodium mucronatum aerial parts on isolated rat thoracic aorta precontracted by noradrenaline (NA). In all cases, the aqueous extracts (0.5-12 mg/ml) significantly inhibited, in a concentration-dependent manner, the maximal contractile response induced by NA in rat aorta. The most active extract was that of G. glauca flowers. These findings indicate that the active principle(s) present in the crude extracts can exert a vasorelaxant effect.
D000818:Animals; D001013:Aorta, Thoracic / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000494:pharmacology; D066298:In Vitro Techniques; D008297:Male; D008519:Medicine, Traditional; D008800:Mexico; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000378:metabolism; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D014661:Vasoconstriction / Q000187:drug effects
D010936:Plant Extracts; D004837:Epinephrine