Screening for in vitro antifungal activities of some indole alkaloids.
Several indole alkaloids were tested by the agar dilution technique on a panel of human pathogenic fungi, yeasts, and dermatophytes. Our results indicate that the most active compounds possess a beta-carboline skeleton and that the presence of a 3-4 double bond enhances the activity. Our results also show that antifungal activities are not linked to the cytotoxic, antimicrobial or antiparasitic properties.
D000470:Alkaloids / Q000737:chemistry / Q000494:pharmacology*; D000935:Antifungal Agents / Q000737:chemistry / Q000494:pharmacology*; D002243:Carbolines / Q000032:analysis; D004353:Drug Evaluation, Preclinical; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D000470:Alkaloids; D000935:Antifungal Agents; D002243:Carbolines; D007211:Indoles