title: [The prevalence of secondary resistance to peroral hypoglycemic agents among patients with type-2 diabetes mellitus].
abstract: Prevalence of secondary resistance to peroral sugar-reducing agents (PSRA) among patients with type II diabetes mellitus was studied. The majority of patients (81%) who were allocated to insulin treatment for the first time had received peroral sugar-reducing preparation prior to that treatment. Mean duration of illness in these patients was 9.94 +/- 0.6 years. Females predominated among those persons showing resistance to PSRA; they all presented with obesity.
mesh_terms: D000284:Administration, Oral; D000328:Adult; D017677:Age Distribution; D002908:Chronic Disease; D003924:Diabetes Mellitus, Type 2 / Q000188:drug therapy* / Q000453:epidemiology; D003927:Diet, Diabetic; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007004:Hypoglycemic Agents / Q000008:administration & dosage / Q000037:antagonists & inhibitors*; D007328:Insulin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D017678:Sex Distribution; D013997:Time Factors; D014455:Ukraine / Q000453:epidemiology
chemical_list: D007004:Hypoglycemic Agents; D007328:Insulin
vernacular_title: Rasprostranennost' vtorichnoĭ rezistentnosti k peroral'nym sakharosnizhaiushchim sredstvam sredi bol'nykh sakharnym diabetom II tipa.