title: [Significance of lymph node metastases in differentiated thyroid carcinoma].
abstract: 464 patients with differentiated thyroid carcinoma were scored and treated using a risk-oriented management scheme employing early surgical re-intervention including compartment-oriented lymph-node dissection in cases of lymph-node metastases or local recurrences without routine external radiotherapy. A multivariate analysis showed that there was no effect of lymph-node metastases on survival. The difference in survival between patients with (24%) and without (76%) lymph-node metastases (univariate analysis) were due to the coincidence of higher tumor stage (T4) and higher incidence of peripheral metastases (M1). Thus, provided surgery is efficient, N1 is not a risk factor influencing survival.
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology / Q000601:surgery; D000704:Analysis of Variance; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging / Q000401:mortality / Q000473:pathology / Q000601:surgery; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008207:Lymphatic Metastasis; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011859:Radiography; D012086:Reoperation; D018570:Risk Assessment; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000401:mortality / Q000473:pathology / Q000601:surgery*
chemical_list: D007457:Iodine Radioisotopes
vernacular_title: Bedeutung von Lymphknotenmetastasen beim differenzierten Schilddrüsenkarzinom.