title: Phosphonothrixin, a novel herbicidal antibiotic produced by Saccharothrix sp. ST-888. II. Structure determination.
abstract: Phosphonothrixin (1) is a novel herbicidal agent produced by Saccharothrix sp. ST-888. This unique compound possessing a C-P bond and an isoprene unit was determined to be 2-hydroxy-2-hydroxymethyl-3-oxobutyl-phosphonic acid. Unusually rapid proton-deuterium (H-D) exchange of the methyl ketone unit of this antibiotic in D2O solution was observed. Phosphonothrixin can be classified as a new type of natural product herbicide having a C-P bond in the molecule.
mesh_terms: D000192:Actinomycetales; D000900:Anti-Bacterial Agents / Q000737:chemistry*; D006540:Herbicides / Q000737:chemistry*; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D006540:Herbicides; D063065:Organophosphonates; C096940:phosphonothrixin