Effects of pyridoxal 5'-phosphate on plasma alanine aminotransferase determinations in toxicological studies.
Alanine aminotransferase activities (ALT) were measured in rat plasma samples with three different reagent formulations. The inclusion of pyridoxal 5'-phosphate in the reagent produced higher ALT values, and altered the statistical relationships between control and treatment groups in three studies where plasma ALT values were reduced by xenobiotics.
D000410:Alanine Transaminase / Q000097:blood*; D000818:Animals; D001774:Blood Chemical Analysis / Q000379:methods*; D005069:Evaluation Studies as Topic; D005260:Female; D007202:Indicators and Reagents; D008297:Male; D011732:Pyridoxal Phosphate / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D015262:Xenobiotics / Q000633:toxicity*
D007202:Indicators and Reagents; D015262:Xenobiotics; D011732:Pyridoxal Phosphate; D000410:Alanine Transaminase