Failure of aspirin and diltiazem to prevent the formation of acute coronary thrombi in dogs.
The aim of the present study was to determine the efficacy of aspirin and diltiazem in preventing the formation of coronary thrombi in dogs. Canine coronary thrombi were produced by inserting a small catheter filled with collagen powder into the endothelial-injured, partially occluded left anterior descending coronary artery. Neither aspirin (bolus of 30 mg/kg, followed by 100 mg/kg/h by infusion), nor diltiazem (0.1 mg/kg, followed by 0.3 mg/kg/h by infusion) prevented the formation of coronary thrombi. The mortality in aspirin group was significantly higher than that in control and diltiazem groups. These results indicate that aspirin and diltiazem do not inhibit thrombus formation in the canine model of coronary thrombosis.
D000818:Animals; D001241:Aspirin / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003326:Coronary Circulation / Q000187:drug effects; D003328:Coronary Thrombosis / Q000473:pathology / Q000517:prevention & control*; D004110:Diltiazem / Q000627:therapeutic use*; D004285:Dogs; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D008297:Male; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*
D002317:Cardiovascular Agents; D010975:Platelet Aggregation Inhibitors; D004110:Diltiazem; D001241:Aspirin