The chemical synthesis of Leishmania donovani phosphoglycan via polycondensation of a glycobiosyl hydrogenphosphonate monomer.
A polycondensation of 2,3,6-tri-O-benzoyl-4-O-(2,3,4-tri-O-benzoyl-beta-D-galactopyranosyl)-al pha-D-mannopyranosyl hydrogenphosphonate in the presence of trimethylacetyl chloride has been used to synthesize a linear poly[beta-D-galactopyranosyl-(1-->4)-alpha-D-mannopyranosyl phosphate] representing the phosphoglycan part of the lipophosphoglycan from Leishmania donovani.
D000818:Animals; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004187:Disaccharides / Q000737:chemistry*; D006028:Glycosphingolipids / Q000138:chemical synthesis*; D007893:Leishmania donovani / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008969:Molecular Sequence Data; D015394:Molecular Structure; D063065:Organophosphonates / Q000737:chemistry*
C097032:2,3,6-tri-O-benzoyl-4-O-(2,3,4-tri-O-benzoylgalactopyranosyl)mannopyranosyl hydrogen phosphonate; D004187:Disaccharides; D006028:Glycosphingolipids; D063065:Organophosphonates; C008290:lipophosphonoglycan