Abnormalities of chromosome 5q correlate with morphologic features of better prognosis in clear cell renal carcinomas.
Aberrations of the long arm of chromosome 5 (5q) were studied in 79 clear cell renal carcinomas (clear cell RCC) by LOH (loss of heterozygosity) method, using microsatellite markers D5S107, CRTL1, LNS-CA, IL-9.RP1, CFS1R and GeneScan analysis software. Alterations of chromosome 5q were detected in 42% of cases. We found, that accumulation of genomic abnormalities at multiple loci of 5q, especially in 5q21-qter region, where genes for cytokines are located, correlates with morphologic features of better prognosis.
D018262:Adenocarcinoma, Clear Cell / Q000235:genetics* / Q000473:pathology; D001483:Base Sequence; D002869:Chromosome Aberrations / Q000235:genetics*; D002895:Chromosomes, Human, Pair 5 / Q000235:genetics*; D016207:Cytokines / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis; D005819:Genetic Markers; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics* / Q000473:pathology; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011379:Prognosis
D016207:Cytokines; D004273:DNA, Neoplasm; D005819:Genetic Markers