Effect of pyrrolidone carboxylate (PCA) and pyridoxine on liver metabolism during chronic ethanol intake in rats.
Rats subjected to chronic ethanol intake for a period of 28 days showed significant elevation in blood ethanol levels, a marked decrease in hepatic reduced glutathione (GSH) content and a decrease in liver tryptophan pyrrolase (TPO) activity. A daily intraperitoneal injection of a combined solution of pyrrolidone carboxylate (PCA) and vitamin B6 (pyridoxine hydrochloride) (0.3 mmoles/kg) into ethanol-treated rats resulted in the blood ethanol levels becoming significantly reduced, while the hepatic GSH content and TPO activity were markedly elevated. Our results support the view that PCA and pyridoxine operate to restore the redox imbalance of the hepatocytes caused by chronic alcohol intake.
D000437:Alcoholism / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D004359:Drug Therapy, Combination; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000378:metabolism*; D008297:Male; D009711:Nucleotides / Q000378:metabolism; D011725:Pyridines / Q000378:metabolism; D011736:Pyridoxine / Q000627:therapeutic use*; D011761:Pyrrolidonecarboxylic Acid / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014366:Tryptophan Oxygenase / Q000378:metabolism
D009711:Nucleotides; D011725:Pyridines; D014366:Tryptophan Oxygenase; D005978:Glutathione; D011736:Pyridoxine; D011761:Pyrrolidonecarboxylic Acid