Quality control in the secretory pathway.
Whereas newly synthesized proteins that have acquired a properly folded and assembled structure are transported from the endoplasmic reticulum to their final destinations, incompletely folded and assembled proteins are, as a rule, retained and eventually degraded. The molecular mechanisms of this unique molecular sorting phenomenon, called 'quality control', have been illuminated by recent studies.
D000818:Animals; D001692:Biological Transport; D004721:Endoplasmic Reticulum / Q000378:metabolism; D006031:Glycosylation; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism; D018832:Molecular Chaperones / Q000378:metabolism; D017510:Protein Folding; D011506:Proteins / Q000378:metabolism*; D011786:Quality Control
D008565:Membrane Proteins; D018832:Molecular Chaperones; D011506:Proteins