[The erythrocyte pro-oxidant and antioxidant systems of patients with chronic kidney failure].
Lipid peroxidation as shown by malonic dialdehyde (MDA) levels and enzymic antioxidant defense systems were evaluated in red cells from patients with renal affections free of chronic renal failure (group 1), in conservative curable stage of chronic renal failure (group 2a), in terminal stage nondialysis patients (group 2b) and in healthy donors. MDA was higher in patients, in group 2b in particular. MDA levels correlated with concentrations of endogenic creatinine in the serum. Catalase and glutathione peroxidase were at control levels. SOD was not changed in group 1 but appeared reduced in other groups. Its activity was not related to serum creatinine. An inverse relationship existed between MDA content and SOD activity in red cells. It is believed that progression of chronic renal insufficiency leads to activation of lipid peroxidation and deterioration of antioxidant defense in red cells contributing to more active red cell destruction causing anemia in uremia.
D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism*; D004912:Erythrocytes / Q000737:chemistry / Q000201:enzymology*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000201:enzymology* / Q000628:therapy; D015227:Lipid Peroxidation; D008297:Male; D008875:Middle Aged; D017382:Reactive Oxygen Species / Q000032:analysis / Q000378:metabolism*
D000975:Antioxidants; D017382:Reactive Oxygen Species
Sostoianie prooksidantnoĭ i antioksidantnoĭ sistem éritrotsita u bol'nykh s khronicheskoĭ pochechnoĭ nedostatochnost'iu.