[Benefits and adverse effects of post-operative radiation therapy after radical cystectomy for patients with advanced bladder cancer].
BACKGROUND
The benefits and adverse effects of post-operative irradiation for advanced bladder cancer patients were investigated.


METHODS
Ten patients with pT3b, pT4 or pN+ bladder cancer who underwent radical cystectomy at Yamanashi Medical University hospital during 7 years and 3 months from October 1983 to December 1991 received adjuvant chemotherapy and radiotherapy (Group 1). During the same period, six patients with recurrent tumor after radical cystectomy were treated by radiotherapy (Group II). Stages of the primary tumors were pT2 in 1, pT3a in 2, pT3b in 6 and pT4 in 7 cases. In addition, 10 of 16 patients (63%) had positive nodes.


RESULTS
During the follow up period, seven patients died of cancer, and one died of other cause. As a result eight patients (5 in Group I, 3 in Group II) are alive. The cumulative 5-year survival rate is 50%. However, nine of the 16 patients (56%) suffered from the small bowel obstruction as an adverse effect of irradiation. Six patients required resection of the small bowel or bypass surgery.


CONCLUSIONS
Radiation after radical cystectomy seemed to be effective for the local control of the tumor, but the adverse effect to the digestive system was very severe and common.
D000368:Aged; D017024:Chemotherapy, Adjuvant; D000075202:Contraindications; D015653:Cystectomy; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011182:Postoperative Care; D011832:Radiation Injuries / Q000209:etiology*; D011878:Radiotherapy; D018714:Radiotherapy, Adjuvant; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery