Progressive multifocal leukoencephalopathy complicating treatment for Wegener's granulomatosis.
We describe a man treated with cyclophosphamide and prednisone for Wegener's granulomatosis who developed biopsy proven progressive multifocal leukoencephalopathy (PML). Upon discontinuation of immunosuppression he made a dramatic recovery. As immunosuppressant use is increasing we draw attention to this potentially fatal, but reversible neurologic disease.
D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D003520:Cyclophosphamide / Q000009:adverse effects*; D014890:Granulomatosis with Polyangiitis / Q000188:drug therapy*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007577:JC Virus / Q000302:isolation & purification; D007968:Leukoencephalopathy, Progressive Multifocal / Q000209:etiology* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011859:Radiography
D007166:Immunosuppressive Agents; D003520:Cyclophosphamide