Effects of the antiestrogen tamoxifen on low-density lipoprotein concentrations and oxidation in postmenopausal women.
Our study demonstrates that tamoxifen, when administered to postmenopausal women at a conventional dosage, reduces LDL levels and protects LDL from oxidation. The protective effect of tamoxifen against the development of breast cancer in women considered at risk is being investigated in a placebo-controlled trial sponsored by the National Institutes of Health. Whether tamoxifen also protects against the development of cardiovascular disease in this trial is also of considerable interest.
D018592:Cross-Over Studies; D004311:Double-Blind Method; D004965:Estrogen Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood / Q000378:metabolism*; D008875:Middle Aged; D010084:Oxidation-Reduction; D017698:Postmenopause / Q000187:drug effects* / Q000378:metabolism; D013629:Tamoxifen / Q000627:therapeutic use*
D004965:Estrogen Antagonists; D008077:Lipoproteins, LDL; D013629:Tamoxifen