title: Brachytherapy in sarcomas.
abstract: Historically, amputation was the standard local treatment for soft tissue sarcomas of the extremity. Although this procedure provided excellent local control, the adverse impact of this procedure on quality of life was obvious. In an effort to maximize the functional outcome of sarcoma therapy, various groups initiated studies aimed at doing less radical operations in conjunction with radiation therapy.
mesh_terms: D000206:Actuarial Analysis; D000671:Amputation, Surgical; D001918:Brachytherapy / Q000009:adverse effects; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005121:Extremities; D005260:Female; D006801:Humans; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000532:radiotherapy; D010166:Palliative Care; D011446:Prospective Studies; D011788:Quality of Life; D018714:Radiotherapy, Adjuvant; D016032:Randomized Controlled Trials as Topic; D012189:Retrospective Studies; D012509:Sarcoma / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D012983:Soft Tissue Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D016896:Treatment Outcome; D014945:Wound Healing / Q000528:radiation effects