Experimental evidence of ototoxicity of ear drops. A review of the literature.
Evidence of ototoxicity as derived from laboratory experiments on animal models and from a few prospective controlled studies in man is reviewed. Data are gathered for the different components and antibiotics contained in ototopical preparations. An attempt is made to answer the question whether these laboratory findings are valid in the clinical situation in man.
D000287:Administration, Topical; D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000633:toxicity*; D004195:Disease Models, Animal; D006199:Hair Cells, Auditory, Inner / Q000187:drug effects; D006319:Hearing Loss, Sensorineural / Q000139:chemically induced*; D006801:Humans; D009092:Mucous Membrane / Q000187:drug effects; D012996:Solutions; D013045:Species Specificity
D000900:Anti-Bacterial Agents; D012996:Solutions