[The effect of calcium-regulating hormones on the renal transport of calcium in hypertension].
Enhanced and diminished calcemia following administration of parathormone and calcitonin in hypertensive patients, respectively, were found not to differ from relevant values in healthy subjects. Calciuretic effect of parathormone results from its action on the bone and renal calcium transport. Quantitatively, the effects on the bone and renal calcium transport. Quantitatively, the effects on the bone presenting as elevated calcemia and calcium filtration capacity, its excreted fraction and renal excretion prevail, being less pronounced in hypertensive patients. A direct renal effect of parathyroid hormone indicated by stimulation of calcium tubular reabsorption is weaker in hypertensive subjects. Calcitonin administration inhibits tubular calcium reabsorption in the less degree in hypertensive subjects. The disorders in calciuretic function of the kidney in hypertension are secondary to reduced kidney sensitivity to the action of calcium regulating hormones.
D000328:Adult; D001692:Biological Transport / Q000187:drug effects; D002116:Calcitonin / Q000008:administration & dosage / Q000494:pharmacology*; D002118:Calcium / Q000032:analysis / Q000378:metabolism*; D004231:Diuresis / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000188:drug therapy / Q000378:metabolism* / Q000503:physiopathology; D007273:Injections, Intramuscular; D007668:Kidney / Q000187:drug effects* / Q000378:metabolism / Q000503:physiopathology; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000008:administration & dosage / Q000494:pharmacology*; D013054:Spectrophotometry, Atomic
D010281:Parathyroid Hormone; C039549:parathyroidin; D002116:Calcitonin; D002118:Calcium
Vliianie kal'tsiĭreguliruiushchikh gormonov na pochechnyĭ transport kal'tsiia pri gipertonicheskoĭ bolezni.