4-Guanidino-Neu5Ac2en fails to protect chickens from infection with highly pathogenic avian influenza virus.
The effectiveness of the novel sialidase inhibitor 4-guanidino-Neu5Ac2en, which is highly effective in mouse and ferret models of influenza virus infection (von Itzstein et al. (1993) Nature 363, 418-423), has been assessed as a prophylactic agent in the prevention of infection of chickens with highly pathogenic avian influenza viruses. At best a small delay in the onset of pyrexia and death was observed with one strain of fowl plague virus, but not with two other strains. These results demonstrate that a locally acting drug may be ineffective if virus can escape from the site of inoculation and replicate elsewhere.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001831:Body Temperature; D002460:Cell Line; D002645:Chickens; D006146:Guanidines; D009980:Influenza A virus / Q000187:drug effects / Q000472:pathogenicity; D005585:Influenza in Birds / Q000401:mortality / Q000517:prevention & control*; D011714:Pyrans; D012794:Sialic Acids / Q000494:pharmacology*; D053243:Zanamivir
D000998:Antiviral Agents; D006146:Guanidines; D011714:Pyrans; D012794:Sialic Acids; D053243:Zanamivir