Calcitonin gene-related peptide innervation of A2-catecholamine cells in the nucleus of the solitary tract of the rat.
By using double immunolabeling light and electron microscopic techniques, dense neuronal network of calcitonin-related peptide (CGRP) has been visualized in the nucleus of the solitary tract with complete overlapping of the tyrosine hydroxylase (TH)-containing cells. TH-immunoreactive perikarya and dendrites were seen in synaptic contact with CGRP-immunopositive fibers, indicating that CGRP, by carrying sensory signals may influence autonomic regulatory mechanisms in the NTS through local catecholaminergic neurons.
D000818:Animals; D001341:Autonomic Nervous System / Q000737:chemistry*; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D007124:Immunoenzyme Techniques; D008297:Male; D009638:Norepinephrine / Q000032:analysis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017552:Solitary Nucleus / Q000737:chemistry* / Q000166:cytology; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
D014446:Tyrosine 3-Monooxygenase; D015740:Calcitonin Gene-Related Peptide; D009638:Norepinephrine