title: The effects of a carotid-jugular fistula on cerebral blood flow in the cat: an experimental study in the chronic period.
abstract: The purpose of the present study was to investigate the effects of feline carotid-jugular fistula (Spetzler's model) on cerebral blood flow at 8 weeks after creation of the fistula. Using laser-Doppler flowmetry, cortical cerebral blood flow (CBF) on the fistula side was measured in 10 cats, Occlusion of the fistula showed no cortical CBF changes in 6 animals, but transient increases in 4. CO2 reactivity in the closed fistula was preserved. No neurological or histological abnormalities were recognized. These findings suggested that cerebral hemodynamic changes due to Spetzler's CJ fistula model are minimal even in the chronic period after fistulization. Therefore, creation of another experimental arterio-venous fistula model is mandatory for the investigation of hemodynamic changes following resection of a cerebral arteriovenous malformation.
mesh_terms: D000818:Animals; D001164:Arteriovenous Fistula / Q000503:physiopathology*; D002340:Carotid Artery Diseases / Q000503:physiopathology*; D002415:Cats; D002560:Cerebrovascular Circulation / Q000502:physiology*; D002908:Chronic Disease; D004195:Disease Models, Animal; D006439:Hemodynamics / Q000502:physiology*; D002538:Intracranial Arteriovenous Malformations / Q000503:physiopathology*; D007601:Jugular Veins