Thalasselis syndrome and genetic theories on keratoconus.
BACKGROUND
Previous theories of the pathogenesis of keratoconus have only described partial aspects of the disease.


METHODS
Studies are reviewed that have demonstrated a statistical and physiological relation between keratoconus, magnesium deficiency, type A behavior, and allergy, which constitute the Thalasselis Syndrome.


RESULTS
The Thalasselis syndrome integrates old and new theories on keratoconus, mitral valve prolapse, and tetany/menopause. Keratoconus is also associated with genetic diseases like Down syndrome, Marfan syndrome, and other conditions related to collagen disturbance and biochemical abnormalities in protein synthesis.


CONCLUSIONS
This syndrome suggests that the genetic disturbance that causes these alterations could be influenced by metabolic factors in which magnesium deficiency could be involved.
D000015:Abnormalities, Multiple / Q000209:etiology*; D003094:Collagen / Q000378:metabolism; D003315:Cornea / Q000378:metabolism; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology*; D007640:Keratoconus / Q000209:etiology* / Q000378:metabolism; D008274:Magnesium / Q000378:metabolism; D008275:Magnesium Deficiency / Q000209:etiology*; D013577:Syndrome; D014434:Type A Personality
D003094:Collagen; D008274:Magnesium