title: Interferon-alpha hybrids.
abstract: The alpha-interferons (IFN-alpha) belong to a family of polypeptides comprising several subtypes. Using recombinant DNA technology, it has been possible to create IFN hybrids that provide novel combinations of the amino acid residues from the parental protein sequences. They have been used to study structure-activity relationships of IFN-alpha and interactions with the IFN-alpha receptor, and to create analogs of natural IFNs with novel properties for potential therapeutic application. The biological data obtained with these hybrids are now evaluated in terms of the published structural and homology models of IFN-beta and -alpha.
mesh_terms: D000818:Animals; D002417:Cattle; D003198:Computer Simulation; D004274:DNA, Recombinant / Q000737:chemistry / Q000235:genetics; D005786:Gene Expression Regulation / Q000235:genetics; D006801:Humans; D016898:Interferon-alpha / Q000737:chemistry / Q000145:classification / Q000235:genetics / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D007694:Killer Cells, Natural / Q000166:cytology / Q000187:drug effects; D051379:Mice; D008961:Models, Structural; D009154:Mutation; D017471:Receptors, Interferon / Q000187:drug effects* / Q000378:metabolism; D013329:Structure-Activity Relationship; D009626:Terminology as Topic
chemical_list: D004274:DNA, Recombinant; D016898:Interferon-alpha; D017471:Receptors, Interferon