EPR study of spermine interaction with multilamellar phosphatidylcholine liposomes.
The interaction of spermine with egg-yolk phosphatidylcholine liposomes was investigated. The EPR spin labeling technique evidenced that spermine induces modifications of some membrane functions of biological interest like water permeability and is a possible modulator of diffusion processes for charged and polar molecules. The association constant for a hypothesized complex between spermine and the phosphate group of phosphatidylcholine was evaluated by enzymatic methods.
D003497:Cyclic N-Oxides / Q000378:metabolism; D004578:Electron Spin Resonance Spectroscopy; D008051:Lipid Bilayers / Q000378:metabolism; D008081:Liposomes / Q000378:metabolism*; D015335:Molecular Probes / Q000737:chemistry / Q000378:metabolism; D010713:Phosphatidylcholines / Q000378:metabolism*; D013096:Spermine / Q000378:metabolism* / Q000494:pharmacology; D013113:Spin Labels; D013229:Stearic Acids / Q000737:chemistry / Q000378:metabolism
D003497:Cyclic N-Oxides; D008051:Lipid Bilayers; D008081:Liposomes; D015335:Molecular Probes; D010713:Phosphatidylcholines; D013113:Spin Labels; D013229:Stearic Acids; D013096:Spermine