Effect of microbial fractions and vehicle on survival of mice bearing Lewis lung carcinoma.
Mice bearing pulmonary metastases of the Lewis lung carcinoma were treated iv with a nonviable microbial vaccine following amputation of the primary inoculation site. The vaccine consisted of BCG cell wall skeleton, trehalose, dimycolate, and endotoxin attached to mineral oil microdroplets. Single and repeated doses ranging from 15 to 675 micrograms were tested. Survival was modestly but consistently prolonged by vaccination. A portion of the activity appeared to be due to the Tween saline-oil vehicle. A single low dose (15 micrograms) was as efficacious as higher or repeated doses.
D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage / Q000627:therapeutic use*; D002277:Carcinoma / Q000628:therapy*; D002462:Cell Membrane / Q000276:immunology; D003311:Cord Factors / Q000008:administration & dosage; D004731:Endotoxins / Q000008:administration & dosage; D007275:Injections, Intravenous; D008175:Lung Neoplasms / Q000556:secondary / Q000628:therapy*; D051379:Mice; D008810:Mice, Inbred C57BL; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000628:therapy; D011136:Polysorbates / Q000008:administration & dosage*
D001500:BCG Vaccine; D003311:Cord Factors; D004731:Endotoxins; D011136:Polysorbates