[The myeloperoxidase of the polymorphonuclear leukocytes as a marker of the stage of Opisthorchis invasion and as an indicator of the efficacy of chemotherapy].
A total of 152 patients with Opisthorchis infection at the acute and chronic stage of the diseases, as well as 1-3 days and 1-2 months after therapy with biltricide in a dose of 60 mg/kg body weight. Intracellular myeloperoxidase was spectrophotometrically determined. Its activity was demonstrated to be significantly varying at the different opisthorchiasis stage. At the acute stage there was a 6-fold increase in the activity of the enzyme as compared with that at the chronic stage. The therapy resulted in the drop of myeloperoxidase levels, at the same time the authors interpret the heterodirectional changes in the activity of myeloperoxidase in the early post-therapeutic period as a fact of individual anthelmintic intolerance the normalization of the parameter studied 1 month after the therapy only in 42.1% of the cases as a fact residual Opisthorchis antigen persistence.
D000208:Acute Disease; D000980:Antiplatyhelmintic Agents / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D004341:Drug Evaluation; D006801:Humans; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology*; D009889:Opisthorchiasis / Q000188:drug therapy* / Q000201:enzymology*; D009195:Peroxidase / Q000097:blood* / Q000187:drug effects; D011223:Praziquantel / Q000627:therapeutic use*; D013053:Spectrophotometry; D013997:Time Factors
D000980:Antiplatyhelmintic Agents; D015415:Biomarkers; D011223:Praziquantel; D009195:Peroxidase
Mieloperoksidaza polimorfno-iadernykh leĭkotsitov kak marker stadii opistorkhoznoĭ invazii i indikator éffektivnosti khimioterapii.