Sheep gene mapping: assignment of ALDOB, CYP19, WT and SOX2 by somatic cell hybrid analysis.
Twenty-four hamster-sheep hybrid cell lines representing eleven ovine synteny groups were used to make syntenic assignments for seven loci ALDOB (aldolase B, fructose biophosphate); AMH (anti-Müllerian hormone); CYP19 [cytochrome P450 aromatase, subfamily XIX (aromatization of androgens)]; WT (Wilms' tumour gene); SOX2 (SRY-related HMG-box gene 2); FSHB (follicle-stimulating hormone, beta polypeptide); and SRY (sex region of Y chromosome). These loci were assigned to synteny groups U11(chr2) (ALDOB); U19 (AMH); U3(chr7) (CYP19); and to chromosome 15 (WT) and 1 (SOX2). SRY defines the hybrids containing the Y chromosome.
D000818:Animals; D054304:Anti-Mullerian Hormone; D001141:Aromatase / Q000235:genetics*; D001483:Base Sequence; D002874:Chromosome Mapping; D017931:DNA Primers; D004268:DNA-Binding Proteins / Q000235:genetics*; D005640:Follicle Stimulating Hormone / Q000235:genetics; D037201:Follicle Stimulating Hormone, beta Subunit; D005634:Fructose-Bisphosphate Aldolase / Q000235:genetics*; D016162:Genes, Wilms Tumor; D006023:Glycoproteins; D006131:Growth Inhibitors / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D008297:Male; D008969:Molecular Sequence Data; D009095:Mullerian Ducts; D009687:Nuclear Proteins; D016133:Polymerase Chain Reaction; D051876:Sex-Determining Region Y Protein; D012756:Sheep / Q000235:genetics*; D013735:Testicular Hormones / Q000235:genetics; D014157:Transcription Factors; D014998:Y Chromosome
D017931:DNA Primers; D004268:DNA-Binding Proteins; D037201:Follicle Stimulating Hormone, beta Subunit; D006023:Glycoproteins; D006131:Growth Inhibitors; D009687:Nuclear Proteins; C497745:SRY protein, human; D051876:Sex-Determining Region Y Protein; D013735:Testicular Hormones; D014157:Transcription Factors; D054304:Anti-Mullerian Hormone; D005640:Follicle Stimulating Hormone; D001141:Aromatase; D005634:Fructose-Bisphosphate Aldolase