[Changes in the weight of the uterus, ovaries and adrenal glands in sexually mature rats treated with estradiol and reserpine].
Immature rats of the Wistar strain were used for the experiments. The treatment was administrated on the 35, 36, 37th day after delivery. The animals were divided into 4 groups. The first group received only saline solution, the second group were treated with reserpine, the third group with estradiole, and the forth group with both reserpine and estradiole. The animals were sacrificed on the 38th day after delivery. There was a statistically significant increase in the weight of the uterus and the ovaries after treatment with estradiole alone, and the same was observed for the group treated with reserpine and estradiole. The latter showed less increase in the uterine weight, which might be due to an impairment of estradiole synthesis caused by reserpine. The wight of the adrenal glands of the immature female rats was increased after treatment with estradiole and reserpine. This implies an involvement of the adrenergic system in the interaction between estradiole and testosterone in immature rats.
D000311:Adrenal Glands / Q000187:drug effects*; D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects*; D011247:Pregnancy; D051381:Rats; D012110:Reserpine / Q000494:pharmacology*; D012741:Sexual Maturation / Q000187:drug effects*; D013997:Time Factors; D014599:Uterus / Q000187:drug effects*
D004958:Estradiol; D012110:Reserpine
Promeni v tegloto na matkata, iaĭchnitsite i nadbŭbretsite na polovo-nezreli plŭkhcheta, tretirani s estradiol i rezerpin.