Mutations in immunoglobulin V gene promoters may cause reduced germline transcription and diminished recombination frequencies.
D001402:B-Lymphocytes / Q000378:metabolism; D001483:Base Sequence; D002999:Clone Cells; D004254:DNA Nucleotidyltransferases / Q000378:metabolism; D005786:Gene Expression Regulation; D015322:Gene Rearrangement, B-Lymphocyte; D005803:Genes, Immunoglobulin; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D007146:Immunoglobulin lambda-Chains / Q000235:genetics; D008745:Methylation; D008969:Molecular Sequence Data; D009154:Mutation; D011401:Promoter Regions, Genetic; D011995:Recombination, Genetic; D014158:Transcription, Genetic; D045567:VDJ Recombinases
D007135:Immunoglobulin Variable Region; D007146:Immunoglobulin lambda-Chains; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases