Parametric stimulation of hemopoietic stem cells in normals and in certain leukemias.
The paper discusses certain distributive and clustering modes of stimulus P and of its receptors. When combined with topologic features peculiar to sources and stem cells, these parameters account not only for the cycling variations typical of normal stem cells but also for seemingly paradoxical shifts in proliferative activity of cells grafted into patients with chronic myeloid leukemias.
D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000502:physiology*; D006801:Humans; D007938:Leukemia / Q000503:physiopathology*; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000503:physiopathology / Q000628:therapy; D008954:Models, Biological; D012016:Reference Values