title: The emergence of clathrin-independent pinocytic pathways.
abstract: Receptor-mediated endocytosis via clathrin-coated vesicles is by far the best characterized example of pinocytosis. It has been suggested that clathrin-coated vesicles mediate all pinocytosis in mammalian cells. This is still a matter of debate, however, and recent results provide strong evidence for 'clathrin-independent' pinocytic pathways. The selective regulation of these alternate endocytic pathways and the identification of receptors targeted to them provide new tools for the functional and mechanistic characterization of clathrin-independent pinocytosis.
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D002966:Clathrin / Q000502:physiology*; D018699:Coated Vesicles / Q000502:physiology; D034281:Dynamins; D020558:GTP Phosphohydrolases / Q000502:physiology; D006801:Humans; D008969:Molecular Sequence Data; D010873:Pinocytosis / Q000502:physiology; D015854:Up-Regulation
chemical_list: D002966:Clathrin; D020558:GTP Phosphohydrolases; D034281:Dynamins