Interleukin-10 in the vitreous of patients with primary intraocular lymphoma.
OBJECTIVE
To find an accurate and simple method to diagnose primary intraocular lymphoma.


METHODS
We prospectively analyzed concentrations of interleukin-10, interleukin-1, interleukin-2, interleukin-4, and interleukin-6 in vitrectomy specimens from three patients with primary intraocular lymphoma and five patients with uveitis by enzyme-linked immunosorbent assay.


RESULTS
Interleukin-10 in the vitreous was detected in patients with primary intraocular lymphoma. Interleukin-10 levels correlated with clinical activity and the number of malignant cells.


CONCLUSIONS
Concentrations of interleukin-10 in the vitreous may be a helpful clue to both clinicians and pathologists in diagnosing primary intraocular lymphoma.
D004797:Enzyme-Linked Immunosorbent Assay; D005134:Eye Neoplasms / Q000175:diagnosis* / Q000601:surgery; D006801:Humans; D016753:Interleukin-10 / Q000032:analysis*; D007378:Interleukins / Q000032:analysis; D016393:Lymphoma, B-Cell / Q000175:diagnosis* / Q000601:surgery; D011446:Prospective Studies; D014605:Uveitis / Q000175:diagnosis / Q000601:surgery; D014821:Vitrectomy; D014822:Vitreous Body / Q000737:chemistry*
D007378:Interleukins; D016753:Interleukin-10