A simple method for estimating the skeletal uptake of diphosphonates.
It is possible to obtain an estimate of the bone uptake of diphosphonates after 3 h (BU) on the basis of the difference between the dose administered and the sum of the component eliminated in the urine plus the component present in the extra-osseous volume of distribution. The results of this simple method have been compared in 15 patients using whole body retention at 24 h (determined by means of a complete urine collection) and the ratio of plasma concentrations of 51Cr-EDTA/99Tcm-HMDP after 3 h (DPS). Both DPS and BU can be used on a practical basis, and therefore be used routinely with scintigraphy. The added advantage is that, for BU, the use of a second radiopharmaceutical is avoided.
D000328:Adult; D000368:Aged; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000378:metabolism*; D002860:Chromium Radioisotopes / Q000097:blood / Q000493:pharmacokinetics; D004164:Diphosphonates / Q000493:pharmacokinetics*; D004492:Edetic Acid / Q000032:analysis / Q000493:pharmacokinetics; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D011877:Radionuclide Imaging; D012016:Reference Values; D012044:Regression Analysis; D013669:Technetium Tc 99m Medronate / Q000031:analogs & derivatives* / Q000493:pharmacokinetics
D002860:Chromium Radioisotopes; D004164:Diphosphonates; C024226:technetium Tc 99m hydroxymethylene diphosphonate; D004492:Edetic Acid; D013669:Technetium Tc 99m Medronate