Seizure-induced activation of enkephalin- and somatostatin-synthesizing neurons.
The extent of the neuronal network that is activated by kainic acid-induced seizures was anatomically identified and neurochemically characterized. Seizure-activated neurons were identified through the immunocytochemical demonstration of Fos protein in neuronal nuclei. These seizure-activated neurons were characterized by determining if they contained the mRNA for somatostatin or enkephalin, using in situ hybridization procedures. The results demonstrate that a majority of enkephalin- and somatostatin-synthesizing neurons expressed the Fos protein following seizures and that they represent a major component of the kainic acid-induced, seizure-activated neuronal network.
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004745:Enkephalins / Q000096:biosynthesis*; D005786:Gene Expression Regulation; D007608:Kainic Acid; D008297:Male; D009474:Neurons / Q000378:metabolism*; D009928:Organ Specificity; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D012640:Seizures / Q000378:metabolism*; D013004:Somatostatin / Q000096:biosynthesis*
D004745:Enkephalins; D012333:RNA, Messenger; D013004:Somatostatin; D007608:Kainic Acid