title: Estimating multipoint recombination fractions.
abstract: The likelihood in linkage investigations can be expressed as a polynomial in the relevant recombination fractions. With polymorphic characters, this can be reduced to a product of separate factors for female and male recombinations, with only mild loss of information. With three generation data the polynomials take a specially simple form. Algorithms are given for finding maximum likelihood estimates and their standard errors.
mesh_terms: D005260:Female; D008040:Genetic Linkage; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008957:Models, Genetic; D010375:Pedigree; D011995:Recombination, Genetic; D012727:Sex Characteristics