title: [Adsorption of aclacinomycin A onto polyisobutylcyanoacrylate nanoparticles].
abstract: The mechanism of adsorption of aclacinomycin A onto polyisobutylcyanoacrylate nanoparticle and the factors effecting the adsorption were studied. The adsorption process reached equilibrium in 15 minutes. The results showed that the surface charge densities of the nanoparticles, pH, ionic strength and temperature effected the adsorption. Adsorption isotherms of aclacinomycin A onto polyisobutylcyanoacrylate nanoparticles could be described with Freundlich equation Y = 1.0188 C0.6494 (r = 0.9945) and with Langmuir equation C/Y = 0.7363C + 0.4027 (r = 0.9331) respectively. The main actions between aclacinomycine A and polyisobutylcyanoacrylate nanoparticles were electrostatic and ionic action.
mesh_terms: D015250:Aclarubicin / Q000008:administration & dosage* / Q000737:chemistry; D000327:Adsorption; D003487:Cyanoacrylates; D016503:Drug Delivery Systems; D004659:Enbucrilate; D006863:Hydrogen-Ion Concentration; D008863:Microspheres; D011108:Polymers
chemical_list: D003487:Cyanoacrylates; D011108:Polymers; D015250:Aclarubicin; D004659:Enbucrilate