A model for beta-amyloid aggregation and neurotoxicity based on the free radical generating capacity of the peptide: implications of "molecular shrapnel" for Alzheimer's disease.
D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000633:toxicity*; D000818:Animals; D003402:Creatine Kinase / Q000037:antagonists & inhibitors; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals; D005849:Gerbillinae; D005974:Glutamate-Ammonia Ligase / Q000037:antagonists & inhibitors; D006801:Humans; D006900:Hydroxylation; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000201:enzymology; D009498:Neurotoxins / Q000633:toxicity*; D012459:Salicylates / Q000378:metabolism; D013113:Spin Labels; D013574:Synaptosomes / Q000187:drug effects / Q000378:metabolism
D016229:Amyloid beta-Peptides; D005609:Free Radicals; D009498:Neurotoxins; D012459:Salicylates; D013113:Spin Labels; D003402:Creatine Kinase; D005974:Glutamate-Ammonia Ligase