Differential distribution of norepinephrine and serotonin along the dorsal-ventral axis of the hippocampal formation.
Norepinephrine (NE) and Serotonin (5-HT) are differentially distributed along the dorsal-ventral axis of the Hippocampal Formation (HF). A kinetic analysis of the uptake of labeled NE and 5-HT was performed to assess the relative density of nerve terminals which accumulate NE and 5-HT (Vmax) and the apparent affinity for uptake (Km). The results reveal a greater density of NE and 5-HT terminals in the ventral HF and a higher Km for 5-HT uptake in the dorsal HF. The results are discussed in terms of potential explanation of reported differences following independent manipulation of the dorsal and ventral hippocampal formation.
D000818:Animals; D006624:Hippocampus / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000378:metabolism*; D051381:Rats; D011941:Receptors, Adrenergic / Q000378:metabolism; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011985:Receptors, Serotonin; D012701:Serotonin; D009638:Norepinephrine