[The effect of thymalin, dalargin and "Mucosalin" on the course of an experimental duodenal ulcer].
A peptide was obtained at our chair, from the mucous membrane of the stomach of the pig, using a method of acid extraction. The above peptide belongs to the group of cytomedines and is conventionally called "mucozaline". As many as 80 Wistar male rats were used in comparative evaluation of thymaline, dallargine and "mucozaline" for their effect on the course of duodenal ulcer in the rat. The results obtained showed that regulatory peptides play an important part in protection of the gastric and duodenal mucosa against the damaging factors. Of the above agents, it is "mucozaline" that has the greatest protective action, with dallargine and thymaline following it in the declining order.
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D003543:Cysteamine; D004353:Drug Evaluation, Preclinical; D004381:Duodenal Ulcer / Q000139:chemically induced / Q000188:drug therapy*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005753:Gastric Mucosa; D008297:Male; D010455:Peptides / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013552:Swine; D013951:Thymus Hormones / Q000627:therapeutic use*
D000276:Adjuvants, Immunologic; D000897:Anti-Ulcer Agents; D010455:Peptides; D013951:Thymus Hormones; C053892:cytomedins; D003543:Cysteamine; D016308:Enkephalin, Leucine-2-Alanine; C032805:thymalin; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie timalina, dalargina i "Mukozalina" na techenie éksperimental'noĭ iazvy dvenadtsatiperstnoĭ kishki.