title: [The effects of intramuscular and oral prophylaxis with vitamin K on the coagulation status of low-weight newborn infants].
abstract: The present prospective study carried out in 1993 in the SFH "Maĭchin Dom"--Sofia, includes newborn infants with birth weight below 2500 g. and aims to compare the effect of the prophylaxis of the haemorrhagic disease of the newborn by intramuscular and peroral application of vit. K. For this purpose some coagulation screening tests were followed out in intervals of 4-5 days during the first two weeks of life. These two groups are compared between one another and with non-prophylacted with vit. K healthy newborn babies. The results so obtained allow to make the conclusion that, on one side, the haemostasis of newborns with low birth weight is very labile and, on another, that the peroral and the intramuscular ways of prophylaxis with vit. K have the same effectiveness.
mesh_terms: D000284:Administration, Oral; D000375:Aging / Q000097:blood; D000704:Analysis of Variance; D001777:Blood Coagulation / Q000187:drug effects*; D001780:Blood Coagulation Tests / Q000706:statistics & numerical data; D006801:Humans; D007230:Infant, Low Birth Weight / Q000097:blood*; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D011446:Prospective Studies; D014812:Vitamin K / Q000008:administration & dosage*; D006475:Vitamin K Deficiency Bleeding / Q000517:prevention & control
chemical_list: D014812:Vitamin K
vernacular_title: Efekti ot intramuskulnata i oralnata profilaktika s vitamin K vŭrkhu sŭstoianieto na koagulatsiiata pri novrodeni detsa s nisko teglo.