Inhibitory effects of Cistus populifolius on contractile responses in the isolated rat duodenum.
The medicinal plant Cistus populifolius L., shows an important dose-dependent spasmolytic activity. The ability of the Cistus extract to inhibit both acetylcholine (ACh) (3.4 x 10(-8)-6.8 x 10(-5) M) and CaCl2 (2 x 10(-4)-1.28 x 10(-2) M)-induced contractions and the relaxing effect on K+ (75 mM)-induced contractions may indicate a non-specific receptor antagonist. However, this action may be related to the influx of extracellular Ca2+. These antispasmodic effects are partly consistent with the use of C. populifolius in folk medicine for certain gastrointestinal disorders.
D000109:Acetylcholine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D000818:Animals; D002122:Calcium Chloride / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004386:Duodenum / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects; D009126:Muscle Relaxation / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects*; D010276:Parasympatholytics / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D011188:Potassium / Q000037:antagonists & inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D010276:Parasympatholytics; D010936:Plant Extracts; D002122:Calcium Chloride; D000109:Acetylcholine; D011188:Potassium