4-Hydroxyphenylretinamide in the chemoprevention of cancer.
It has been suggested that ultimately half of all cancers might be prevented by early interventions (Costa, 1993). 4HPR has been shown to be an effective and safe agent in various in vivo animal trials and well tolerated in human trials. At present multiple clinical trials are assessing its efficacy in preventing a variety of cancers.
D018890:Chemoprevention; D004358:Drug Therapy; D017313:Fenretinide / Q000009:adverse effects / Q000494:pharmacology* / Q000627:therapeutic use*; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D012176:Retinoids / Q000494:pharmacology*
D012176:Retinoids; D017313:Fenretinide