title: [The impact of the prevention of cerebral toxoplasmosis].
abstract: In France, where 70% of adults are latently infected by toxoplasma, from 20% to 40% of patients with AIDS developed toxoplasmic encephalitis until recently. The prophylactic use of drugs which are active against pneumocystis and toxoplasma has proven to be efficient. These drugs are trimethoprim-sulfamethoxazole or dapsone-pyrimethamine. With the extent of these primary prophylaxis, there is a decrease of risk of toxoplasma encephalitis; thus the rate of toxoplasma encephalitis among opportunistic infections has fallen off from 19% of the patients in 1988 to 6% in 1994, in the department of infectious diseases of the Pitié-Salpêtrière hospital. However, toxoplasmic abscesses occurring despite the prophylaxis are frequently slow growing lesions which can become huge with a moderate mass effect, mimicking the pattern of primary cerebral lymphoma. The rule of antitoxoplasmic trial treatment must be strictly followed, even under prophylaxis.
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000517:prevention & control*; D000328:Adult; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000627:therapeutic use; D000981:Antiprotozoal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D001922:Brain Abscess / Q000175:diagnosis / Q000469:parasitology; D001932:Brain Neoplasms / Q000175:diagnosis; D018890:Chemoprevention; D003622:Dapsone / Q000008:administration & dosage / Q000627:therapeutic use; D003937:Diagnosis, Differential; D004338:Drug Combinations; D004660:Encephalitis / Q000469:parasitology / Q000517:prevention & control; D005602:France; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000175:diagnosis; D011739:Pyrimethamine / Q000008:administration & dosage / Q000627:therapeutic use; D016781:Toxoplasmosis, Cerebral / Q000517:prevention & control*; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000890:Anti-Infective Agents; D000981:Antiprotozoal Agents; D004338:Drug Combinations; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D003622:Dapsone; D011739:Pyrimethamine
vernacular_title: Impact de la prévention de la toxoplasmose cérébrale.