title: Tannic acid is not mutagenic in germ cells but weakly genotoxic in somatic cells of Drosophila melanogaster.
abstract: Tannic acid (TA) was tested for genotoxic activity in three different assays (1-3) in Drosophila melanogaster by feeding of larvae or adult flies. TA did not induce sex-linked recessive lethals (1) nor sex-chromosome loss, mosaicism or non-disjunction (2) in male germ cells. In the wing somatic mutation and recombination test (SMART) (3) TA was found to be toxic for larvae of the high bioactivation cross and produced a weak positive response. These results suggest that this compound, when administered orally to larvae or adults of D. melanogaster, is not mutagenic and clastogenic in male germ cells, but weakly genotoxic in somatic cells of the wing imaginal disk.
mesh_terms: D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D017344:Genes, Insect / Q000187:drug effects; D005804:Genes, Lethal; D005808:Genes, Recessive; D047348:Hydrolyzable Tannins / Q000633:toxicity*; D007814:Larva; D008297:Male; D009030:Mosaicism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009630:Nondisjunction, Genetic; D011995:Recombination, Genetic; D012729:Sex Chromosome Aberrations
chemical_list: D047348:Hydrolyzable Tannins; D009153:Mutagens