Serum lactate dehydrogenase isoenzyme 1. An early indicator of relapse in patients with testicular germ cell tumors.
The present study aimed to evaluate serum lactate dehydrogenase isoenzyme 1 (S-LD-1) as an indicator of relapse for patients with testicular germ cell tumors. Twenty-seven patients were investigated with repeated determinations of S-LD-1 from diagnosis to relapse; 9 had seminoma and 18 nonseminomatous tumors. Eleven of 21 had raised S-LD-1 at relapse (4 with seminoma). Seven of the 27 patients had a raised S-LD-1 for median 2 months (1.4-4.5 months) before relapse was detected. Thus, S-LD-1 is of use, complementary to clinical examinations, determinations of serum alpha fetoprotein and human chorionic gonadotropin, and CT scans, in monitoring patients with testicular germ cell tumors for relapse.
D000293:Adolescent; D000328:Adult; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood; D004796:Clinical Enzyme Tests; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D009373:Neoplasms, Germ Cell and Embryonal / Q000201:enzymology / Q000473:pathology*; D018239:Seminoma / Q000201:enzymology / Q000473:pathology*; D013736:Testicular Neoplasms / Q000201:enzymology / Q000473:pathology*; D013997:Time Factors
D014408:Biomarkers, Tumor; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase