Inhibition of urethan induced lung tumour growth in strain A mice by 5-methyl cytidine.
In two in vivo experiments, low doses of 5-methyl cytidine significantly suppressed the growth of urethan-induced lung tumours in strain A mice while higher doses were less effective. This inverse dose-response relationship mimics the previously reported effect of 5-methyl cytidine on mammary tumour growth in C3H mice. The finding that 5-methyl cytidine inhibits lung tumour growth as well as mammary tumour growth suggests this nucleoside may be an effective inhibitor of solid tumour growth in general. A study of the effect of 5-methyl cytidine on mouse lung tumour cell viability in vitro suggests that the direct cytotoxic effect of 5-methyl cytidine is dependent on the cell cycle. Since cell-cycle dependent agents do not inhibit lung tumour growth in vivo, 5-methyl cytidine probably inhibits mouse lung tumour growth indirectly by some effect on the host rather than by a direct cytotoxic effect on the lung tumour.
D000236:Adenoma / Q000139:chemically induced / Q000188:drug therapy*; D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002470:Cell Survival / Q000187:drug effects; D003562:Cytidine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D008175:Lung Neoplasms / Q000139:chemically induced / Q000188:drug therapy*; D051379:Mice; D009374:Neoplasms, Experimental / Q000188:drug therapy; D014520:Urethane
D014520:Urethane; D003562:Cytidine; C016568:5-methylcytidine