title: Saccharin-induced hyperplasia of the rat urinary bladder.
abstract: Dietary administration of sodium saccharin to male Fischer rats increased the rate of DNA synthesis of the urinary bladder epithelium as measured by tritiated thymidine uptake. A multifocal mild epithelial hyperplasia was induced, which was most readily detected by scanning electron microscopy, with pleomorphic microvilli present on many of the hyperplastic cells.
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004247:DNA / Q000096:biosynthesis; D006965:Hyperplasia / Q000139:chemically induced; D008297:Male; D051381:Rats; D012439:Saccharin / Q000494:pharmacology*; D001743:Urinary Bladder / Q000187:drug effects* / Q000473:pathology
chemical_list: D004247:DNA; D012439:Saccharin