title: Different expression of the myotonin protein kinase gene in discrete areas of human brain.
abstract: We have examined the myotonin protein kinase (MT-PK) gene expression in different human brain areas. Four different spliced forms, comprising exons 13 and 14, were identified and characterized. One form (MYOT-A), lacking the entire exon 13, had not been detected in other studies and it is likely to be a brain-specific transcript. Different brain areas show a specific transcription pattern. These results suggest that MT-PK may have specialized functions in different areas of central nervous system. Alterations of this complex expression pattern could be responsible for the mental status impairment observed in myotonic dystrophy patients.
mesh_terms: D017398:Alternative Splicing; D001483:Base Sequence; D001921:Brain / Q000201:enzymology*; D017931:DNA Primers; D005091:Exons; D015870:Gene Expression; D006801:Humans; D008969:Molecular Sequence Data; D065636:Myotonin-Protein Kinase; D009928:Organ Specificity; D016133:Polymerase Chain Reaction; D011494:Protein Kinases / Q000096:biosynthesis* / Q000235:genetics; D017346:Protein Serine-Threonine Kinases; D014158:Transcription, Genetic
chemical_list: C585517:DMPK protein, human; D017931:DNA Primers; D011494:Protein Kinases; D065636:Myotonin-Protein Kinase; D017346:Protein Serine-Threonine Kinases