Gabapentin toxicity in children manifesting as behavioral changes.
Pediatric experience with gabapentin (GBP), a new antiepileptic drug (AED), is limited. We described 3 learning disabled children, 1 aged 7 and 2 aged 10 years, with intractable partial seizures who developed severe behavioral problems while receiving modest doses of GBP. The children became hyperactive and had explosive outburst consisting of aggressive and oppositional behavior. The behavioral problems were sufficiently severe to require discontinuation of GBP despite moderately improved seizure control.
D000085:Acetates / Q000009:adverse effects*; D000339:Affect / Q000187:drug effects; D000374:Aggression; D000588:Amines; D000927:Anticonvulsants / Q000009:adverse effects*; D001519:Behavior / Q000187:drug effects*; D002648:Child; D003509:Cyclohexanecarboxylic Acids; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D000077206:Gabapentin; D006801:Humans; D008297:Male; D012640:Seizures / Q000188:drug therapy*; D016896:Treatment Outcome; D005680:gamma-Aminobutyric Acid
D000085:Acetates; D000588:Amines; D000927:Anticonvulsants; D003509:Cyclohexanecarboxylic Acids; D005680:gamma-Aminobutyric Acid; D000077206:Gabapentin