Pressor response induced by the hippocampal administration of neostigmine is suppressed by M1 muscarinic antagonist.
We investigated the roles played by three muscarinic receptors (M1, M2, and M3) in the pressor response with bradycardia that followed the injection of neostigmine (5 x 10(-8) mol) into the hippocampus of anesthetized rats. These changes were blocked by the co-administration of methylatropine (5 x 10(-8) mol). The intrahippocampal injection of pirenzepine (M1 antagonist) (5 x 10(-9) - 5 x 10(-7) mol) suppressed the neostigmine-induced pressor response dose-dependently. However injection of gallamine (M2 antagonist) (5 x 10(-8) - 5 x 10(-7) mol) and of 4-DAMP (M1 and M3 antagonist) (5 x 10(-8) - 5 x 10(-7) mol) did not suppress this hypertensive response. These findings suggest that the neostigmine-induced pressor response with bradycardia is mediated through the M1 muscarinic receptor subtype.
D000818:Animals; D001286:Atropine Derivatives / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D004347:Drug Interactions; D005703:Gallamine Triethiodide / Q000494:pharmacology; D006339:Heart Rate / Q000187:drug effects; D006624:Hippocampus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D018727:Muscarinic Antagonists / Q000494:pharmacology*; D009388:Neostigmine / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010277:Parasympathomimetics / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D010880:Piperidines / Q000494:pharmacology; D010890:Pirenzepine / Q000494:pharmacology; D011311:Pressoreceptors / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D011976:Receptors, Muscarinic / Q000145:classification / Q000502:physiology
D001286:Atropine Derivatives; D018727:Muscarinic Antagonists; D010277:Parasympathomimetics; D010880:Piperidines; D011976:Receptors, Muscarinic; D009388:Neostigmine; D010890:Pirenzepine; C006649:methylatropine; C042375:4-diphenylacetoxy-1,1-dimethylpiperidinium; D005703:Gallamine Triethiodide