Effects of chronic social stress on tyrosine hydroxylase mRNA and protein levels.
Males housed in mixed sex groups quickly form dominance hierarchies; subordinates can be further subdivided into stress responsive subordinates (SRS) and non-responsive subordinates (NRS) based on corticosterone responses to a novel stressor. Tyrosine hydroxylase (TH) mRNA levels measured with in situ hybridization were elevated in locus coeruleus (LC) of NRS compared to singly or pair-housed controls; NRS also had higher TH levels than dominants. TH protein levels determined by immunoautoradiography were also higher in LC of NRS and SRS versus pair-housed controls.
D000818:Animals; D001483:Base Sequence; D002908:Chronic Disease; D005260:Female; D008125:Locus Coeruleus / Q000201:enzymology; D008297:Male; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D012930:Social Dominance; D013315:Stress, Psychological / Q000201:enzymology*; D014446:Tyrosine 3-Monooxygenase / Q000235:genetics*
D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D014446:Tyrosine 3-Monooxygenase