Controlled release of multi-component cytotoxic agents from radiation polymerized composites.
Multi-component cytotoxic (anticancer) agents such as mitomycin C (MMC), adryamycin (ADM) and 1-(2-tetrahydrofuryl-5-fluorouracil) (FT-207), were entrapped in a single common composite by radiation-induced polymerization of glass-forming monomers in the presence of polymers. The release profiles of each cytotoxic agent were controlled by the contents and compositions of three cytotoxic agents in the matrix. The release rates of each cytotoxic agent were retarded by addition of an adsorbent and accelerated by addition of a pore-making agent. The release fom the common matrix of a cytotoxic agent and its promoter which have markedly different molecular weights [e.g. MMC and urokinase (UK)] was also investigated. A double entrapping method was successfully used for controlled release in such cases. In conclusion it was found that the release profiles of multi-components in a single matrix could be controlled by using these techniques.
D003692:Delayed-Action Preparations; D004317:Doxorubicin / Q000008:administration & dosage* / Q000528:radiation effects; D005472:Fluorouracil / Q000008:administration & dosage* / Q000528:radiation effects; D066298:In Vitro Techniques; D008937:Mitomycins / Q000008:administration & dosage* / Q000528:radiation effects; D011108:Polymers / Q000528:radiation effects; D013927:Thrombosis; D014466:Ultraviolet Rays
D003692:Delayed-Action Preparations; D008937:Mitomycins; D011108:Polymers; D004317:Doxorubicin; D005472:Fluorouracil