Re-emergence of GAP-43 in cochlear nucleus and superior olive following cochlear ablation in the rat.
The effect of cochlear lesion on the expression of the growth associated protein GAP-43 in superior olive and cochlear nucleus was studied in the rat. In normal development of these auditory brainstem nuclei, GAP-43 immunoreactivity is high perinatally but low 10 days postnatally or thereafter. Removal of one spiral ganglion in grown-up animals caused a substantial re-emergence of GAP-43 immunoreactivity in varicose fibers of the ipsilateral ventral cochlear nucleus and cell bodies of the lateral superior olive. These findings suggest that a reactive synaptogenesis takes place in the cochlear nucleus as a consequence of deafening through spiral ganglion loss.
D000818:Animals; D001306:Auditory Pathways / Q000378:metabolism; D017626:Cochlear Nucleus / Q000378:metabolism*; D019922:GAP-43 Protein; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000096:biosynthesis* / Q000378:metabolism; D009412:Nerve Fibers / Q000276:immunology; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000378:metabolism; D009473:Neuronal Plasticity / Q000502:physiology*; D009847:Olivary Nucleus / Q000502:physiology*; D010750:Phosphoproteins / Q000096:biosynthesis* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D019922:GAP-43 Protein; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D010750:Phosphoproteins