title: Biochemical and genetic dissection of mitotic chromosome condensation.
abstract: The molecular mechanisms responsible for mitotic chromosome condensation are unknown. Two independent approaches, biochemical studies in vertebrate cells and genetic analyses in yeasts, have converged recently, leading to the identification of a family of putative ATPases that play a fundamental role in this process. Further characterization of these proteins promises to uncover a highly dynamic aspect of mitotic chromosome architecture.
mesh_terms: D000251:Adenosine Triphosphatases / Q000502:physiology; D000818:Animals; D002875:Chromosomes / Q000737:chemistry* / Q000235:genetics*; D007399:Interphase; D008938:Mitosis; D009687:Nuclear Proteins / Q000502:physiology
chemical_list: D009687:Nuclear Proteins; D000251:Adenosine Triphosphatases