Technetium-99m-sestamibi imaging with nitrate infusion to detect viable hibernating myocardium and predict postrevascularization recovery.
We tested the relationship of nitrate-induced changes in 99mTc-sestamibi perfusion tomography and first-pass radionuclide angiocardiography (FPRNA) with postrevascularization functional recovery of asynergic territories.


METHODS
Twenty-eight patients, all with prior infarction and left ventricular dysfunction, underwent two 99mTc-sestamibi rest studies: one under baseline conditions and the other with nitrate infusion. The baseline study was repeated after revascularization. Changes in global and regional perfusion and ventricular function were evaluated by perfusion tomography and FPRNA. Hibermating myocardium was identified by functional recovery in postrevascularization FPRNA.


RESULTS
Eleven patients and 31 segments in 19 coronary territories had functional recovery. Nitrate-induced FPRNA changes showed poor agreement with postrevascularization modifications: kappa = 0.24, ns, for the global and kappa = 0.32, p < 0.01 for regional function. The agreement between nitrate-induced and postrevascularization perfusion changes was good both considering the patients (k = 0.57, p < 0.01) and the abnormal coronary territories (k = 0.63, p < 0.0005). The agreement of nitrate-induced perfusion changes with postrevascularization functional outcome was excellent on a patient (k = 1, p < 0.0005), and coronary territory basis (k = 0.82, p < 0.0005). Conversely, the agreement between nitrate and postrevascularization FPRNA was poor: k = 0.18, ns.


CONCLUSIONS
These data suggest that the nitrate-induced changes in 99mTc-sestamibi perfusion imaging are useful to detect hibernating myocardium which recovers its function after revascularization.
D000787:Angina Pectoris / Q000000981:diagnostic imaging* / Q000628:therapy; D005260:Female; D006801:Humans; D007548:Isosorbide Dinitrate; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging* / Q000628:therapy; D009204:Myocardial Revascularization; D011237:Predictive Value of Tests; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon; D014665:Vasodilator Agents; D018487:Ventricular Dysfunction, Left / Q000000981:diagnostic imaging* / Q000628:therapy; D015646:Ventriculography, First-Pass
D014665:Vasodilator Agents; D017256:Technetium Tc 99m Sestamibi; D007548:Isosorbide Dinitrate