title: [DNA polymorphism of the BoLA-DRB3 gene in cattle in connection with resistance and susceptibility to leukemia].
abstract: Polymorphism of exon 2 of the BoLA-DRB3 gene was investigated by the PCR-RFLP method in a sample of healthy and leukemia-afflicted Black Pied cattle. Allele variety was studied and allele frequencies were determined in a total sample and in the two groups. Alleles mediating resistance (BoLA-DRB3.2*11, *23, and *28) and susceptibility to leukemia (DRB3.2*22, *24, *16, and *8) were revealed in Black Pied cattle. The dominant type of inheritance of the disease resistance was confirmed. On the basis of original and published data obtained earlier for Holstein-Friesian cattle, a conclusion was made about the universal character of the spectrum of BoLA-DRB3 alleles providing resistance and susceptibility to leukemia.
mesh_terms: D000483:Alleles; D000818:Animals; D001483:Base Sequence; D002417:Cattle / Q000235:genetics* / Q000276:immunology; D004247:DNA; D017931:DNA Primers; D016583:Enzootic Bovine Leukosis / Q000235:genetics* / Q000276:immunology; D005091:Exons; D005784:Gene Amplification; D005787:Gene Frequency; D020022:Genetic Predisposition to Disease; D006649:Histocompatibility Antigens / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D015183:Restriction Mapping
chemical_list: D017931:DNA Primers; D006649:Histocompatibility Antigens; D004247:DNA
vernacular_title: DNK-polimorfizm gena BoLa-DRB3 u krupnogo rogatogo skota v sviazi s ustoĭchivost'iu i vospriimchivost'iu k leĭkozu.