Recurrent cervical lymphadenopathy due to Ki-1 lymphoma in an elderly female.
A 70-year-old female presented with recurring cervical lymphadenopathy over a 5-year period. Intermittently, symptoms of respiratory and GI tract disease occurred, raising the possibility of malignancy. Investigation of these systems and of the breasts were negative. A lymph node biopsy was eventually done and showed intrasinusoidal proliferations of CD30-positive malignant cells which were also characterized ultrastructurally. Therapy with CHOP has produced a good initial response. The value of electron microscopy in diagnostic pathology is illustrated.
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002467:Cell Nucleus / Q000648:ultrastructure; D003520:Cyclophosphamide / Q000008:administration & dosage; D003593:Cytoplasm / Q000648:ultrastructure; D004317:Doxorubicin / Q000008:administration & dosage; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D007150:Immunohistochemistry; D008198:Lymph Nodes / Q000473:pathology*; D017728:Lymphoma, Large-Cell, Anaplastic / Q000188:drug therapy / Q000473:pathology* / Q000648:ultrastructure; D008854:Microscopy, Electron; D009333:Neck; D011241:Prednisone / Q000008:administration & dosage; D012008:Recurrence; D014750:Vincristine / Q000008:administration & dosage
D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone