[Anticonvulsive effect of the antioxidant ionol].
The influence of the antioxidant ionol on the intensity of epileptic activity in rats has been studied. The epileptic activity was induced by penicillin application to the sensorimotor cortex. It was established that preliminary injection to rats of ionol abolished the effect of lipoperoxidation in the focus of hyperactivity and decreased by a factor of 10(1) the number of seizures recorded on the electrocorticogram in the course of the focus existence.
D000818:Animals; D000927:Anticonvulsants; D000975:Antioxidants / Q000494:pharmacology*; D002084:Butylated Hydroxytoluene / Q000494:pharmacology* / Q000627:therapeutic use; D002540:Cerebral Cortex / Q000378:metabolism; D004569:Electroencephalography; D008054:Lipid Peroxides / Q000096:biosynthesis; D010406:Penicillins; D051381:Rats; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology
D000927:Anticonvulsants; D000975:Antioxidants; D008054:Lipid Peroxides; D010406:Penicillins; D002084:Butylated Hydroxytoluene
Protivosudorozhnyĭ éffekt antioksidanta ionola.