Effect of ibuprofen treatment during experimental acute otitis media.
In this study, the efficacy of concurrent treatment of experimental acute otitis media with ibuprofen and ampicillin was evaluated in chinchillas with respect to clearance of the effusion, presence of mucosal inflammation, and modulation of biochemical markers. Forty chinchillas were infected with non-typable Haemophilus influenzae and randomly assigned to treatment with either IM ampicillin (control) or ampicillin plus ibuprofen beginning on day 2 post inoculation. On days 5 and 10, animals from each group were killed, effusions recovered for biochemical assay, and the middle ears prepared for histological study. Differences in outcome measures favoring the control group were observed at the 5 day endpoint. However, at the 10 day endpoint, mucosal thickness was significantly less, the number of effusion free ears greater, and the concentrations of free fatty acids and thromboxane less in the animals treated with the combined therapy when compared to the control group. These results suggest that the addition of ibuprofen to ampicillin for the treatment of acute otitis media alters disease pathogenesis in this infectious model.
D000208:Acute Disease; D000667:Ampicillin / Q000627:therapeutic use; D000818:Animals; D002682:Chinchilla; D004359:Drug Therapy, Combination; D004432:Ear, Middle / Q000737:chemistry / Q000187:drug effects* / Q000503:physiopathology; D005230:Fatty Acids, Nonesterified / Q000032:analysis; D006193:Haemophilus influenzae / Q000187:drug effects* / Q000472:pathogenicity; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D018655:Lymphocyte Count / Q000187:drug effects; D010033:Otitis Media / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D013931:Thromboxanes / Q000032:analysis
D005230:Fatty Acids, Nonesterified; D013931:Thromboxanes; D000667:Ampicillin; D007052:Ibuprofen