Effect of H2O2 on adriamycin-induced cytotoxicity in vitro.
Normal and malignant cell lines, sensitive and resistant to adriamycin, have been treated with H2O2 to look for the possibility of protection from the cytotoxic action of adriamycin on the cells. Pre-treatment of adriamycin-resistant cells with H2O2 partially protects them against the cytotoxicity of adriamycin.
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D016466:CHO Cells / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D006224:Cricetinae; D004249:DNA Damage; D004317:Doxorubicin / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004351:Drug Resistance; D004790:Enzyme Induction / Q000187:drug effects; D005057:Eukaryotic Cells / Q000187:drug effects*; D005609:Free Radicals; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology*; D008861:Microsomes / Q000187:drug effects / Q000201:enzymology; D016877:Oxidants / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D000903:Antibiotics, Antineoplastic; D005609:Free Radicals; D016877:Oxidants; D004317:Doxorubicin; D006861:Hydrogen Peroxide