[Electrocorticographic evaluation of the neurologic tolerability of iobitridol (Xenetix), a new non-ionic contrast medium in rabbits].
Electro-corticographic tracings (two longitudinal leads, bipolar assembly) were recorded from curarized rabbits (5/group) receiving selective internal carotid artery injections of either iobitridol, a new non-ionic contrast medium, or iohexol, the high osmolar diatrizoate or hypertonic mannitol (isotonic to the non-ionic agents). A further group was submitted to the surgical preparation but was not injected. The solutions were injected at a dose of 2.5 ml during 30 seconds. The animals were anaesthetized (halothane) during the surgical period. The permeability of the blood-brain barrier was assessed by means of the extravasation of Evans'blue. Tracings were visually assessed and a semi-quantitative method for blind evaluation of fast/slow rhythms was used. This method was pharmacologically validated by the use of pentobarbital and pentylenetetrazole. Diatrizoate and iohexol induced respectively 3 and 2 paroxystic tracings during or immediately after the injection period. Iobitridol and hypertonic mannitol did not cause such effect. Paroxystic tracings in the iohexol group were not associated with extravasation of Evans'blue in the cerebral parenchyma. Blood brain barrier was disrupted in all rabbits receiving the high osmolar agent diatrizoate. Tracings of the control group were characterized by a progressive increase of fast rhythms, as those of the iobitridol and mannitol groups. On the contrary, iohexol and especially diatrizoate induced an increase in the proportion of slow waves. Taken together, these data suggest that iobitridol shows an excellent tolerability potential for clinical use.
D000818:Animals; D001812:Blood-Brain Barrier; D001921:Brain / Q000187:drug effects*; D003287:Contrast Media / Q000009:adverse effects*; D003973:Diatrizoate / Q000494:pharmacology; D004569:Electroencephalography; D005119:Extravasation of Diagnostic and Therapeutic Materials; D007472:Iohexol / Q000494:pharmacology; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D011817:Rabbits; D012640:Seizures / Q000139:chemically induced
D003287:Contrast Media; D003973:Diatrizoate; D008353:Mannitol; D007472:Iohexol
Evaluation électrocorticographique de la tolérance neurologique de l'iobitridol (Xenetix), un nouveau produit de contraste non-ionique, chez le lapin.