title: Early detection of rifampin in human nerve tissue after an oral dose of 600 milligrams.
abstract: Rifampin in picogram quantities inhibited the ability of Mycobacterium bovis 44 BCG P3 to release 14CO2 from the oxidation of [14C]palmitic acid. By using these mycobacteria in a bioassay, samples of serum and posterior tibial nerve were assayed for inhibitory concentrations of rifampin. Within 8 to 12 h after ingestion of 600 mg of rifampin, the drug was detected in eight patients in concentrations ranging from 0.52 to 4.1 micrograms/ml in serum and in concentrations ranging from 0.6 to 6.3 ng/mg in posterior tibial nerve fiber tissue.
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001681:Biological Assay; D006801:Humans; D007917:Leprostatic Agents / Q000493:pharmacokinetics* / Q000494:pharmacology; D007918:Leprosy / Q000382:microbiology; D008875:Middle Aged; D009163:Mycobacterium bovis / Q000187:drug effects / Q000378:metabolism; D009417:Nerve Tissue / Q000378:metabolism*; D010084:Oxidation-Reduction; D010169:Palmitic Acids / Q000378:metabolism; D012293:Rifampin / Q000493:pharmacokinetics* / Q000494:pharmacology; D013979:Tibial Nerve / Q000378:metabolism
chemical_list: D007917:Leprostatic Agents; D010169:Palmitic Acids; D012293:Rifampin