title: Experimental Chlamydia pneumoniae infection in mice: effect of reinfection and passive immunization.
abstract: NIH/S mice were infected intranasally with Chlamydia pneumoniae isolate Kajaani 6 and rechallenged after either 28 or 70 days. A partial resistance to reinfection, indicated by a reduced recovery of live organisms, was noted at both time points of rechallenge: positive isolations from lung homogenates and/or bronchoalveolar lavage fluids were observed in fewer mice and the yields of isolated chlamydiae remained smaller, as compared to primary infection. However, a previous infection did not confer any protection against inflammatory changes. A strong peribronchial and perivascular inflammation with infiltrating lymphocytes and plasma cells was noted in the lungs of primary infected, as well as reinfected, mice. The effect of passive immunization was also studied. When mice were given convalescent or hyperimmune sera intraperitoneally before inoculation, lower C. pneumoniae isolation yields were detected. As in the rechallenge experiment, marked inflammation could still be seen in the lungs, now with polymorphonuclear leukocyte infiltration. The results suggest that immunological reactions play a role in the pathogenesis of C. pneumoniae infection. Antibodies may be important in reducing the amount of infective elementary bodies, but complete clearing of C. pneumoniae could not be achieved in these experiments, even less a protection against inflammatory lung changes.
mesh_terms: D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000382:microbiology; D002690:Chlamydia Infections / Q000276:immunology* / Q000503:physiopathology / Q000517:prevention & control; D016993:Chlamydophila pneumoniae / Q000276:immunology; D007116:Immunization, Passive; D007156:Immunologic Memory; D008168:Lung / Q000473:pathology; D051379:Mice