Apolipoprotein A1-derived amyloid in human aortic atherosclerotic plaques.
Amyloid deposits in the aortic intima are very common in association with atherosclerosis and aging. In the present study, a major fibril protein purified from amyloid present in human atherosclerotic plaques was shown to be a 69-amino acid N-terminal fragment of apolipoprotein AI. Although senile form of localized apolipoprotein AI-derived amyloidosis has recently been documented in pulmonary vessels of dogs, this is the first example of a localized human amyloid derived from this apolipoprotein.
D000368:Aged; D000369:Aged, 80 and over; D000595:Amino Acid Sequence; D000682:Amyloid / Q000302:isolation & purification*; D001013:Aorta, Thoracic / Q000737:chemistry / Q000473:pathology*; D016632:Apolipoprotein A-I / Q000302:isolation & purification*; D001161:Arteriosclerosis / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D008969:Molecular Sequence Data
D000682:Amyloid; D016632:Apolipoprotein A-I