Some aspects of neonatal essential fatty acid status are altered by linoleic acid supplementation of women during pregnancy.
To study the effect of maternal linoleic acid [18:2(n-6), LA] supplementation during pregnancy on neonatal essential fatty acid status, pregnant women with relatively low plasma linoleic acid concentrations before 16 wk of gestation (n = 21) were supplied with foods rich in linoleic acid, resulting in an additional intake of 10 g/d of linoleic acid from the 20th week of gestation until delivery. One of the two control groups consisted of pregnant women with comparably low plasma linoleic acid concentrations at the start of the study (LL-control group, n = 22); the other consisted of women with habitually high plasma linoleic acid concentrations (HL-control group, n = 21). The neonatal essential fatty acid status was assessed by determining the fatty acid composition of phospholipids (PL) isolated from umbilical plasma and umbilical vessel walls. The maternal linoleic acid status in the LA-supplemented group increased to a level comparable to that of the HL-control group, but the neonatal linoleic acid status did not differ from that of either control group. Linoleic acid supplementation did result in slightly, but significantly, higher total amounts of (n-6) long-chain polyenes in umbilical plasma and vein vessel wall phospholipids compared with the LL-control group. This increase was associated with significantly lower total amounts of (n-3) long-chain polyenes. In the HL-control group, the concentration of (n-3) long-chain polyenes in umbilical plasma and vessel walls was significantly lower than in the LA-supplemented and the LL-control group.(ABSTRACT TRUNCATED AT 250 WORDS)
D000328:Adult; D005228:Fatty Acids, Essential / Q000097:blood / Q000378:metabolism*; D005260:Female; D005312:Fetal Blood / Q000737:chemistry; D005527:Food, Fortified; D006801:Humans; D007231:Infant, Newborn / Q000378:metabolism*; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D009752:Nutritional Status; D010743:Phospholipids / Q000032:analysis / Q000097:blood; D011090:Polyenes / Q000032:analysis / Q000097:blood / Q000378:metabolism; D011247:Pregnancy / Q000097:blood / Q000378:metabolism*; D011262:Pregnancy Trimester, Second / Q000378:metabolism; D011263:Pregnancy Trimester, Third / Q000378:metabolism
D005228:Fatty Acids, Essential; D008041:Linoleic Acids; D010743:Phospholipids; D011090:Polyenes; D019787:Linoleic Acid