Non-response to a recombinant pre-S2-containing hepatitis B vaccine: association with the HLA-system.
In this study, the immunogenicity of a recombinant pre-S2 containing hepatitis B vaccine was determined in a cohort of 147 homosexual men. Both seroconversion rate and geometric mean titers indicated that pre-S2 was less immunogenic than HBsAg. Forty-eight subjects, including nine non-responders and seven high-responders to HBsAg, were tested for HLA Class I and II antigens to study a possible association between HLA-type and non-response. Both HLA-B8 and HLA-DR3 were clearly overrepresented in non-responders to HBsAg. Non-response to pre-S2, observed in 7/9 non responders and 6/39 responders to HBsAg, was not associated with any of the tested HLA markers.
D000328:Adult; D015331:Cohort Studies; D005805:Genes, MHC Class I; D015795:HLA-B8 Antigen / Q000302:isolation & purification; D015803:HLA-DR3 Antigen / Q000302:isolation & purification; D006514:Hepatitis B Surface Antigens / Q000235:genetics / Q000276:immunology; D017325:Hepatitis B Vaccines / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D011994:Recombinant Proteins
D015795:HLA-B8 Antigen; D015803:HLA-DR3 Antigen; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D011994:Recombinant Proteins