Enteral feeding a structured lipid emulsion containing fish oil prevents the fatty liver of sepsis.
Fish oils (FO) have been shown to reduce plasma triglycerides (TG). In this study we evaluated whether enteral feeding with a structured lipid emulsion (SLE) containing FO and medium-chain triglycerides (MCT) would prevent the hypertriglyceridemia and fatty infiltration of the liver that develops during sepsis. For five days, male Lewis rats (275-300 g) were fed intragastrically a nutritionally complete diet containing a SLE or a similar diet with a soybean oil emulsion (SOE) in place of the SLE. On the fifth day, sepsis was induced by intravenously injecting 8 x 10(7) live Escherichia coli colonies/100 g b.w.; 24 h later the control SLE, septic SLE, control SOE, and septic SOE rats were sacrificed. Diet, but not treatment, had a significant effect on serum TG and free fatty acids (FFA). Feeding the SLE reduced the plasma FFA of the control and septic rats by more than 50% in comparison to both control and septic rats fed the SOE. Soleus muscle activity of lipoprotein lipase from the septic SLE rats was 44% higher than the control SLE rats. Soleus muscle from the septic SLE rats also had a twofold greater activity of lipoprotein lipase than the septic SOE rats. TG did not accumulate in the livers of the septic rats fed SLE when compared to the control SLE rats and the rats fed the SOE. Livers from the septic rats fed the SLE had a third of the TG that were present in the livers from the septic rats fed the SOE.(ABSTRACT TRUNCATED AT 250 WORDS)
D000818:Animals; D002784:Cholesterol / Q000097:blood; D004655:Emulsions; D004750:Enteral Nutrition; D005227:Fatty Acids / Q000008:administration & dosage*; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005234:Fatty Liver / Q000209:etiology / Q000517:prevention & control*; D005395:Fish Oils / Q000008:administration & dosage* / Q000627:therapeutic use; D015228:Hypertriglyceridemia / Q000517:prevention & control; D008099:Liver / Q000378:metabolism; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D018805:Sepsis / Q000150:complications*; D013024:Soybean Oil / Q000008:administration & dosage; D014280:Triglycerides / Q000008:administration & dosage* / Q000097:blood / Q000378:metabolism
D004655:Emulsions; D005227:Fatty Acids; D005230:Fatty Acids, Nonesterified; D005395:Fish Oils; D014280:Triglycerides; D013024:Soybean Oil; D002784:Cholesterol