[Indicators of lipoprotein metabolism in normolipemic men after myocardial infarct].
BACKGROUND
In some patients with ischaemic heart disease disorders of the lipoprotein metabolism were found although the plasma cholesterol and triglyceride levels were not elevated. The objective of the present work was to assess parameters of the lipoprotein metabolism which could differentiate normolipidaemic probands with an increased risk of myocardial infarction.


RESULTS
The authors examined a group of 21 men with normal values of plasma cholesterol and triglycerides who had suffered 6 months to 3 years ago from a myocardial infarction. As compared with a control group of normolipidaemic men without evidence of ischaemic heart disease, these patients had significantly lower HDL-C concentrations (-22%, p < 0.01), in particular due to a lower sub-fraction HDL,-C (-29%, p < 0.001), a higher apolipoprotein B concentration in LDL (+36%, p < 0.00) and a lower value of the cholesterol/apolipoprotein B ratio in LDL (-25%, p < 0.05). The total cholesterol, triglyceride, LDL cholesterol, HDL2-cholesterol, apolipoprotein A-1 concentration and cholesterol/apolipoprotein A-1 ratio in HDL did not different significantly. The method of discrimination analysis revealed that for the differentiation of the two groups assessment of apolipoprotein B in LDL and HDL3-C are most useful. By this approach 80% of the patients in the group were correctly classified.


CONCLUSIONS
The results of the presented work confirmed the importance of assessment of apolipoprotein B and HDL-C, incl. its sub-fractions for estimating the risk of ischaemic heart disease in normolipidaemic subjects.
D006801:Humans; D008055:Lipids / Q000097:blood*; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood*
D008055:Lipids; D008074:Lipoproteins
Ukazatele lipoproteinového metabolismu u normolipidemických muzů po infarktu myokardu.