Antiplatelet activity of synthetic and natural resveratrol in red wine.
The antiaggregating effect of the phytoalexin resveratrol (3,4,5-trihydroxystilbene), alone or associated with red wine, and polyphenol have been evaluated in vitro at different concentrations on platelet-rich plasma from healthy volunteers. Resveratrol at the concentration of 3.56 micrograms/l was able to lower platelet aggregation by 50.3% +/- 1.83. Red wine containing 1.2 mg/l of natural trans-resveratrol and 3.6 milligrams of polyphenols diluted 1000-fold (final resveratrol concentration: 1.2 micrograms/l) inhibited platelet aggregation by 41.9% +/- 2.11. By adding resveratrol to the wine up to a concentration of 1.2 micrograms/l, inhibition was raised to 78.5% +/- 4.70. These results suggest that the antiaggregating activity of resveratrol is related to its concentration in wine.
D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D012016:Reference Values; D000077185:Resveratrol; D013267:Stilbenes / Q000494:pharmacology*; D014920:Wine / Q000032:analysis*
D010975:Platelet Aggregation Inhibitors; D013267:Stilbenes; D000077185:Resveratrol