Molecular linkage of hantavirus pulmonary syndrome to the white-footed mouse, Peromyscus leucopus: genetic characterization of the M genome of New York virus.
The complete M segment sequences of hantaviruses amplified from tissues of a patient with hantavirus pulmonary syndrome in the northeastern United States and from white-footed mice, Peromyscus leucopus, from New York were 99% identical and differed from those of Four Corners virus by 23%. The serum of this patient failed to recognize a conserved, immunodominant epitope of the Four Corners virus G1 glycoprotein. Collectively, these findings indicate that P. leucopus harbors a genetically and antigenically distinct hantavirus that causes hantavirus pulmonary syndrome.
D000595:Amino Acid Sequence; D000818:Animals; D003411:Arvicolinae / Q000821:virology; D000939:Epitopes / Q000032:analysis / Q000737:chemistry; D016679:Genome, Viral; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics* / Q000302:isolation & purification; D018804:Hantavirus Pulmonary Syndrome / Q000635:transmission* / Q000821:virology*; D006801:Humans; D008969:Molecular Sequence Data; D009511:New England; D009518:New York; D010542:Peromyscus / Q000821:virology*; D010802:Phylogeny; D051381:Rats / Q000821:virology; D017386:Sequence Homology, Amino Acid; D014763:Viral Matrix Proteins / Q000235:genetics*
D000939:Epitopes; D014763:Viral Matrix Proteins