title: An antifungal naphthoquinone, xanthones and secoiridoids from Swertia calycina.
abstract: A chemical and biological screening of 25 species of the Gentianaceae family has been undertaken. Both methanolic and dichloromethane extracts of Swertia calycina exhibited a strong antifungal activity against Cladosporium cucumerinum and Candida albicans. The compound responsible for this activity has been isolated and identified as 2-methoxy-1,4-naphthoquinone. It is the first naphthoquinone to be described in Gentianaceae species. LC-UV and LC-TSP-MS analysis of the crude extracts of Swertia calycina also allowed on-line identification of six known xanthones and secoiridoids.
mesh_terms: D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D005960:Glucosides / Q000302:isolation & purification* / Q000494:pharmacology; D057888:Iridoid Glucosides; D039823:Iridoids; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009285:Naphthoquinones / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts; D011714:Pyrans / Q000302:isolation & purification* / Q000494:pharmacology; D012432:Rwanda
chemical_list: D000935:Antifungal Agents; D005960:Glucosides; D057888:Iridoid Glucosides; D039823:Iridoids; D009285:Naphthoquinones; D010936:Plant Extracts; D011714:Pyrans; C096118:2-methoxy-1,4-naphthoquinone; C049412:sweroside