title: Ultrastructure of the hypothalamo-neurohypophysial system in rats exposed to lead. I. Magnocellular nuclei.
abstract: The effect of lead on ultrastructure of supraoptic and paraventricular neurons was studied in rats allowed to drink lead acetate solution instead of water during 6 weeks. Generally, the neurosecretory neurons appeared to be sensitive to lead dependently on its concentrations, but the ultrastructural patterns of the individual neurons varied from cell to cell and suggested the co-existence of the neurons in different functional states such as the increased secretory activity, adaptive responses or cellular degeneration.
mesh_terms: D000818:Animals; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000648:ultrastructure; D007855:Lead Poisoning / Q000097:blood / Q000473:pathology*; D008297:Male; D008854:Microscopy, Electron; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000648:ultrastructure*; D051381:Rats; D017208:Rats, Wistar; D013495:Supraoptic Nucleus / Q000187:drug effects / Q000648:ultrastructure*