Carcinogen-DNA interaction: complexing of distamycin-A with DNA is necessary for its inhibitory effect on the N-methyl-N-nitrosourea induced methylation of DNA.
D000818:Animals; D004247:DNA / Q000378:metabolism*; D004214:Distamycins / Q000494:pharmacology*; D008745:Methylation; D008770:Methylnitrosourea / Q000037:antagonists & inhibitors / Q000378:metabolism*; D009607:Nitrosourea Compounds / Q000378:metabolism*; D011758:Pyrroles / Q000494:pharmacology*; D051381:Rats
D004214:Distamycins; D009607:Nitrosourea Compounds; D011758:Pyrroles; D008770:Methylnitrosourea; D004247:DNA