Caffeine- and aminophylline-induced seizures.
The epileptogenicity of caffeine and aminophylline was studied in rats. Intraperitoneal administration of caffeine produced an immediate excitation and seizures followed by an encephalopathy. A progression from encephalopathy to seizures was observed following aminophylline administration. During the development of behavioral seizures, the EEGs showed a progression from fast activity isolated or bursts of spikes and/or sharp waves to full-blown epileptiform discharges. A wide spectrum of cardiac arrhythmias was observed during and following the seizures. Epileptiform activities ranging from isolated or bursts of spikes and/or sharp waves to continuous epileptiform discharges were observed following local application of the drugs to the cerebral cortex.
D000628:Aminophylline / Q000633:toxicity*; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D002110:Caffeine / Q000633:toxicity*; D002540:Cerebral Cortex / Q000187:drug effects; D004562:Electrocardiography; D004569:Electroencephalography; D005029:Ethylenediamines / Q000009:adverse effects; D007274:Injections, Intraperitoneal; D051381:Rats; D012640:Seizures / Q000139:chemically induced*; D013806:Theophylline / Q000009:adverse effects; D013997:Time Factors
D005029:Ethylenediamines; D000628:Aminophylline; D002110:Caffeine; D013806:Theophylline