title: Alumina as a filler for bone cement: a feasibility study.
abstract: A composite bone cement of Alcoa A-10 Alumina and very finely ground poly(methyl methacrylate) beads (PMMA) was fabricated. It was tested in an attempt to improve on the conventionally used pure PMMA bone cement. By knowing the densities of the powders and their volumes, the mass of each was calculated for the most efficient packing of PMMA and Al2O3 powders and a 65% PMMA: 35% Al2O3 ratio by weight composition was determined. This was tested, as well as the pure cement so comparisons could be made. Cylinders for the strength tests were also made of silane treated Al2O3. The compositions were tested for compressive and tensile strengths. The pure PMMA, composite and silane treated composite had compressive strengths of 79.64 +/- 13.0, 83.17 +/- 4.8, and 71.52 +/- 8.6 MPa and the tensile strengths were 6.69 +/- 0.6, 5.12 +/- 0.3, and 7.12 +/- 0.5 MPa respectively. Also the 65%-35% PMMA-Al2O3 composite required 64% less monomer for mixing than did the pure cement which is thought to be better for tissue healing. The maximum temperature attained from room temperature was 110 degrees-115 degrees C for both cements. The composite took 6.5 min longer to reach its peak temperature than did the pure cement. The bone cements were implanted for one week in a rabbit and both compositions seemed acceptable by the tissue.
mesh_terms: D000535:Aluminum / Q000627:therapeutic use*; D000537:Aluminum Oxide / Q000627:therapeutic use*; D000818:Animals; D001843:Bone Cements / Q000009:adverse effects; D007249:Inflammation; D008768:Methylmethacrylates; D008855:Microscopy, Electron, Scanning; D011817:Rabbits; D013696:Temperature
chemical_list: D001843:Bone Cements; D008768:Methylmethacrylates; D000535:Aluminum; D000537:Aluminum Oxide