title: Mycoserological study of the treatment of paediatric cystic fibrosis patients with Saccharomyces boulardii (Saccharomyces cerevisiae Hansen CBS 5926).
abstract: Saccharomyces boulardii (SB) (Saccharomces cerevisiae Hansen CBS 5926) is a yeast widely used in humans for the prevention and treatment of infectious enterocolitis. SB is said also to antagonize Candida albicans when given orally to living organisms. This double-blind trial was performed to determine the effect and tolerance of SB as an oral therapeutic in patients suffering from cystic fibrosis receiving long-term treatment with cephalosporins or cotrimoxazole, by examining C. albicans counts in the intestine. Extensive mycoserological examinations for drug safety evaluation were also performed. To be selected for the study patients had to present C. albicans in their intestinal flora. None of the patients enrolled exhibited clinical symptoms of candidosis. A daily dose of 750 mg (250 mg t.i.d.) of lyophilized SB given for 21 days did not affect the number of C. albicans commensals in those patients. However, the mycoserological data confirmed the safety of SB treatment with respect to a hypothetically possible SB fungaemia and a possible falsification of Candida serology.
mesh_terms: D000892:Anti-Infective Agents, Urinary / Q000627:therapeutic use; D000908:Antibodies, Fungal / Q000032:analysis; D002176:Candida albicans / Q000302:isolation & purification*; D002177:Candidiasis / Q000517:prevention & control*; D002511:Cephalosporins / Q000627:therapeutic use; D002648:Child; D003550:Cystic Fibrosis / Q000382:microbiology / Q000628:therapy*; D004311:Double-Blind Method; D005243:Feces / Q000382:microbiology; D006801:Humans; D012441:Saccharomyces cerevisiae; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000627:therapeutic use
chemical_list: D000892:Anti-Infective Agents, Urinary; D000908:Antibodies, Fungal; D002511:Cephalosporins; D015662:Trimethoprim, Sulfamethoxazole Drug Combination