title: Effects of L-thyroxine on serum lipid profiles in infants with congenital hypothyroidism.
abstract: Serum lipid profiles and the effects of thyroid hormone on them were studied in infants with congenital hypothyroidism. Serum total cholesterol, high-density lipoprotein cholesterol (HDLC), and low-density lipoprotein cholesterol levels were increased in infants with hypothyroidism;L-thyroxine therapy decreased the HDLC levels, leading to a reduction in serum concentrations of total cholesterol. It appears that thyroid hormone suppresses circulating HDLC, although the mechanism was not discovered in this study.
mesh_terms: D003409:Congenital Hypothyroidism; D006801:Humans; D007037:Hypothyroidism / Q000097:blood / Q000188:drug therapy; D007223:Infant; D007231:Infant, Newborn; D008055:Lipids / Q000097:blood*; D018709:Statistics, Nonparametric; D013974:Thyroxine / Q000008:administration & dosage*
chemical_list: D008055:Lipids; D013974:Thyroxine