title: [Premorbid intelligence diagnosis with the MWT-B(Multiple Choice Word Test-B) in patients with Alzheimer disease].
abstract: The usefulness of the multiple-choice word test (MWT-B) was tested as a measure for premorbid intelligence in 107 patients with probable Alzheimer's disease following the NINCDS-ADRDA criteria. The patients were allocated to three groups according to severity of dementia: mild (n = 40), moderate (n = 41) and severe (n = 26). Dementia severity was assessed with the Mini Mental State Test (MMST). The mean of the raw values of the MWT-B (maximum 37) in the group with mild dementia was 28.0 (SD = 5.57), in the group with moderate dementia 23.3 (SD = 8.01), and in the group with severe dementia 6.7 (SD = 8.44), indicating a parallel worsening with the other tests. The MWT-B value of the whole sample correlated with the MMST value (r = 0.70); a significant correlation still existed in patients with mild and moderate dementia. These results confirm that the MWT-B is relevant for dementia. The rate of cerebral glucose metabolism, measured with positron emission tomography (PET) and 18F-fluorodeoxy-glucose (FDG) correlated significantly with the MWT-B scores in the Alzheimer-sensitive temporoparietal region (r = 0.43; P = 0.001) and frontal brain region (r = 0.37; P < 0.05). Whether or not it can be used as a screening measure of dementia will have to be decided on the basis of its scales for sensitivity and specificity.
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000145:classification / Q000175:diagnosis* / Q000503:physiopathology / Q000523:psychology; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000503:physiopathology; D006801:Humans; D007361:Intelligence Tests / Q000706:statistics & numerical data*; D008609:Mental Status Schedule / Q000706:statistics & numerical data; D008875:Middle Aged; D011594:Psychometrics; D015203:Reproducibility of Results; D014055:Tomography, Emission-Computed; D014825:Vocabulary
chemical_list: D001786:Blood Glucose
vernacular_title: Zur Problematik der prämorbiden Intelligenzdiagnostik mit dem MWT-B bei Patienten mit Alzheimer-Erkrankung.