Nitric oxide in the management of persistent pulmonary hypertension of the newborn--an unusual cause of failure.
A diagnosis of persistent pulmonary hypertension of the newborn should be reviewed if there is a failure to respond to appropriate treatment. We report a case in which both conventional therapy and inhaled nitric oxide failed to break the cycle of right-to-left shunting. Reassessment revealed a massive pulmonary arteriovenous malformation for which surgery was successfully performed in the neonatal period.
D000280:Administration, Inhalation; D001165:Arteriovenous Malformations / Q000175:diagnosis*; D003937:Diagnosis, Differential; D011464:Epoprostenol / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use*; D010547:Persistent Fetal Circulation Syndrome / Q000175:diagnosis / Q000188:drug therapy*; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011651:Pulmonary Artery / Q000002:abnormalities*; D011667:Pulmonary Veins / Q000002:abnormalities*; D012121:Respiration, Artificial; D017211:Treatment Failure; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D010975:Platelet Aggregation Inhibitors; D014665:Vasodilator Agents; D009569:Nitric Oxide; D011464:Epoprostenol