title: Cell cycle dependence of foamy retrovirus infection.
abstract: In common with oncoviruses but unlike the lentivirus human immunodeficiency virus type 1, foamy (spuma) viruses require host cell proliferation for productive infection. We show that human immunodeficiency virus type 1 replicates in RD-CD4 cells regardless of the growth arrest condition of the cells, while murine leukemia virus is unable to infect growth-arrested RD-CD4 cells or cells progressing through a partial cell cycle that includes S phase but not mitosis. Human foamy virus, like murine leukemia virus, does not productively infect G1/S or G2 growth-arrested cells. Two other foamy viruses, simian foamy virus type 1, isolated from a macaque, and simian foamy virus type 6, isolated from a chimpanzee, also fail to establish productive infection in G1/S-arrested cells.
mesh_terms: D000818:Animals; D016590:Aphidicolin / Q000494:pharmacology; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D002453:Cell Cycle / Q000187:drug effects / Q000528:radiation effects; D002455:Cell Division; D002460:Cell Line; D016193:G1 Phase; D016195:G2 Phase; D015497:HIV-1 / Q000472:pathogenicity / Q000502:physiology*; D006801:Humans; D009052:Leukemia Virus, Murine / Q000502:physiology; D008251:Macaca / Q000821:virology; D002679:Pan troglodytes / Q000821:virology; D013045:Species Specificity; D016092:Spumavirus / Q000302:isolation & purification / Q000472:pathogenicity / Q000502:physiology*; D014779:Virus Replication
chemical_list: D016590:Aphidicolin