title: Human and rodent DNA sequence comparisons: a mosaic model of genomic evolution.
abstract: Three patterns of DNA sequence conservation have been identified from five human and rodent genomic sequence comparisons. First, a divergent pattern was observed in the noncoding sequences of the beta-globin and gamma-crystallin gene clusters, and second, a highly conserved pattern was observed in the noncoding regions of the T cell receptor C alpha-C delta, and the alpha- and beta-myosin-heavy-chain genes. A third, mixed pattern has also been found in the immunoglobulin IgH C mu-C delta gene region. These three patterns of genomic evolution pose the fascinating possibility that large portions of the genome evolve at different rates.
mesh_terms: D000818:Animals; D003459:Crystallins / Q000235:genetics; D019143:Evolution, Molecular; D005803:Genes, Immunoglobulin; D005914:Globins / Q000235:genetics; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D008957:Models, Genetic; D018995:Myosin Heavy Chains / Q000235:genetics; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D012377:Rodentia / Q000235:genetics*; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D003459:Crystallins; D011948:Receptors, Antigen, T-Cell; D005914:Globins; D018995:Myosin Heavy Chains