Eicosanoids, fatty acids and neutrophils: their relevance to the pathophysiology of disease.
PUFA and their eicosanoid metabolites are potent biological modifiers. They have beneficial effects in a number of diseases, which may result in part from their direct actions on neutrophils as well as from their ability to modulate eicosanoid biosynthesis. A consideration of their interactions with other cell types, e.g. lymphocytes and macrophages, is beyond the scope of this review. Small alterations in structure can result in large changes in the neutrophil response. This will have important implications for the further development and use of fatty acids for therapeutic purposes.
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism; D004194:Disease / Q000209:etiology*; D015777:Eicosanoids / Q000502:physiology*; D005227:Fatty Acids / Q000502:physiology*; D005395:Fish Oils / Q000494:pharmacology; D006801:Humans; D008084:Lipoxygenase / Q000378:metabolism; D009504:Neutrophils / Q000502:physiology*; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism
D015777:Eicosanoids; D005227:Fatty Acids; D005395:Fish Oils; D016718:Arachidonic Acid; D008084:Lipoxygenase; D011451:Prostaglandin-Endoperoxide Synthases