title: T lymphocyte receptor deficiencies.
abstract: Signalling through the TCR is mediated by the cytoplasmic tails of the CD3 complex. Deficiencies in the expression of different CD3 components have lead to dramatic, yet dissimilar, effects on T-cell development and to selective deficits in peripheral T-cell subsets. Recent studies of human patients and animal models with CD3 deficiencies are providing insights into the redundant and unique roles of these molecules.
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000235:genetics* / Q000276:immunology; D008969:Molecular Sequence Data; D017260:Receptor-CD3 Complex, Antigen, T-Cell / Q000096:biosynthesis / Q000172:deficiency* / Q000235:genetics
chemical_list: D017260:Receptor-CD3 Complex, Antigen, T-Cell