Modification of fat and carbohydrate metabolism by neurohypophyseal hormones. III. Effect of oxytocin on non-esterified fatty acid, glucose, triglyceride and cholesterol levels in rat serum.
The authors determined the effect of s.c. injected oxytocin on serum non-esterified fatty acid, triglyceride, cholesterol and glucose levels in fed and fasting rats of both sexes, in doses of 2.5 and 5 I.U./kg. No changes in non-esterified fatty acid levels were found in fasting animals of either sex. In fed males, non-esterified fatty acid levels rose abruptly after both doses; in fed females they fell after the larger dose. In fed animals of both sexes, the smaller dose of oxytocin produced a decrease, and the larger dose an increase, in triglyceride levels. In fasting females, triglyceride levels fell after both doses; in fasting males a temporary increase was found after the larger dose. In the great majority of cases cholesterol levels displayed a tendency to fall, in both males and females. In the case of glucose, a transient increase was recorded in fed animals of both sexes after the smaller dose and a decrease in males after the larger dose. In fasting animals, glucose levels temporarily rose in every case.
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D005215:Fasting; D005230:Fatty Acids, Nonesterified / Q000097:blood*; D005260:Female; D005502:Food; D007700:Kinetics; D008297:Male; D010121:Oxytocin / Q000494:pharmacology*; D051381:Rats; D012737:Sex Factors; D014280:Triglycerides / Q000097:blood*
D001786:Blood Glucose; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D010121:Oxytocin; D002784:Cholesterol