Creatinine clearance: an inadequate marker of renal filtration in patients with early posthepatitic cirrhosis (Child A) without fluid retention and muscle wasting.
Glomerular filtration rate (GFR) was measured in 19 patients with Child A liver cirrhosis by comparing the endogenous creatinine clearance with inulin clearance. Inulin clearance averaged 90 +/- 4.4 ml/min x 1.73 m2, while creatinine clearance averaged 122 +/- 7 ml/min x 1.73 m2 (p < 0.001). The overestimation of GFR by creatinine was present in 18 of 19 patients and was inversely correlated with inulin clearance (r = -0.452, p < 0.04). The data point to the unsuitability of creatinine as a marker of filtration in early posthepatitic cirrhosis (Child A).
D015415:Biomarkers / Q000032:analysis; D003404:Creatinine / Q000378:metabolism*; D005260:Female; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006505:Hepatitis / Q000150:complications; D006801:Humans; D007444:Inulin / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged
D015415:Biomarkers; D007444:Inulin; D003404:Creatinine