[In vitro modulation of the production of the cytokine HILDA/LIF, secreted by human endometrial explants: preliminary results].
Human endometrium from fertile women secrete HILDA/LIF in vitro. In endometrial explants from women suffering from an unexplained sterility or women whose fertilized eggs do not implant the in vitro secretion is significantly reduced. HILDA/LIF secretion is increased by IL-1 and decreased by IL-4. CSF-1 has little effects on secretion from fertile women but clearly inhibits secretion from some infertile women. Altogether, the results suggest that HILDA/LIF might be involved in human implantation.
D000328:Adult; D046508:Culture Techniques; D010064:Embryo Implantation / Q000187:drug effects / Q000502:physiology*; D004717:Endometrium / Q000187:drug effects / Q000254:growth & development / Q000378:metabolism*; D005260:Female; D006131:Growth Inhibitors / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D007247:Infertility, Female / Q000503:physiopathology*; D007375:Interleukin-1 / Q000502:physiology; D015847:Interleukin-4 / Q000502:physiology; D015850:Interleukin-6; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines / Q000378:metabolism* / Q000502:physiology; D016173:Macrophage Colony-Stimulating Factor / Q000502:physiology
D006131:Growth Inhibitors; D007375:Interleukin-1; D015850:Interleukin-6; C507837:LIF protein, human; D053605:Leukemia Inhibitory Factor; D008222:Lymphokines; D015847:Interleukin-4; D016173:Macrophage Colony-Stimulating Factor
Modulation in vitro de la production de la cytokine HILDA/LIF sécrétée par des explants d'endomètre humain: résultats préliminaires.