Inhibition of visna virus replication and cytopathic effect in sheep choroid plexus cell cultures by selected anti-HIV agents.
Several anti-HIV agents were tested against visna virus replication and cytopathic effect (CPE) in sheep choroid plexus cell cultures. Sulphated polysaccharides (i.e., dextran sulphate, pentosan polysulphate and heparin) and plant lectins, which inhibit viral adsorption and fusion, were found to be 10- to 40-fold less active against visna virus than against HIV. Bicyclam derivatives were at least 250-fold less active against visna virus and the highly HIV-1 specific TIBO derivatives were without a significant inhibitory effect on visna virus at subtoxic concentrations. In contrast, several 2',3'-dideoxynucleosides and acyclic nucleoside phosphonate analogues, which inhibit reverse transcription, were found to be very effective inhibitors of visna virus replication and viral CPE in cell culture.
D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D001570:Benzodiazepinones / Q000494:pharmacology; D002417:Cattle; D002478:Cells, Cultured; D002831:Choroid Plexus / Q000166:cytology; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D015497:HIV-1; D037102:Lectins / Q000494:pharmacology; D011758:Pyrroles / Q000494:pharmacology; D018894:Reverse Transcriptase Inhibitors / Q000494:pharmacology; D012756:Sheep; D014779:Virus Replication / Q000187:drug effects*; D014790:Visna-maedi virus / Q000187:drug effects* / Q000502:physiology
D000998:Antiviral Agents; D001570:Benzodiazepinones; D037102:Lectins; D011758:Pyrroles; D018894:Reverse Transcriptase Inhibitors; C072173:Ro 5-3335