[Stereotaxic destruction of the ventrolateral thalamic nucleus in combination with the transplantation of fetal and xenogeneic tissue in Parkinson's disease].
Four patients with Stage III-IV Parkinson's disease were operated on. Stereotactic cryodestruction of the ventrolateral nucleus was made, followed 10 minutes later by implantation of mixed fetal and xenogenic nerve tissue cells. The nerve cells-the fetal part-are obtained from human fetuses in the age range of 14-18 weeks of development. Tissues from the ventral portion of the midbrain and basal ganglia of the forebrain were used. Neurogenic layings of Notch Drosophila melanogaster mutants serve as a xenograft. The mixture of nerve cells were prepared in ratios of 1000:20 and 1000:12. The follow-up of the patients lasted a year. Relapses were absent. The effect occurred on the operating table (in the combination of nuclear destruction and nerve cell transplantation) and only 6 months later only during transplantation of nerve cells (without destruction). An attempt of transplanting the above fetal xenogenic mixture of nerve cells to patients previously undergone 2 ineffective stereotactic operations provided no significant clinical effect. The concurrent destruction of ventrolateral nuclei in combination with fetal xenogenic tissue grafting is considered to be promising.
D000818:Animals; D001479:Basal Ganglia / Q000196:embryology / Q000637:transplantation; D016380:Brain Tissue Transplantation / Q000379:methods*; D003452:Cryosurgery; D004331:Drosophila melanogaster; D005260:Female; D016332:Fetal Tissue Transplantation / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008636:Mesencephalon / Q000196:embryology / Q000637:transplantation; D008875:Middle Aged; D009417:Nerve Tissue / Q000637:transplantation; D013238:Stereotaxic Techniques; D013787:Thalamic Nuclei / Q000601:surgery*; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
Stereotaksicheskaia destruktsiia ventrolateral'nogo iadra talamusa v sochetanii s transplantatsieĭ fetal'no-ksenogennoĭ tkani pri bolezni Parkinsona.