Changes in pentobarbital induced sleeping-time in mice infected with Schistosoma mansoni and immunosuppressed.
To evaluate whether the intensity of the hepatic granulomatous response induced by S. mansoni eggs plays a role in drug metabolism, mice were infected with 40 cercariae and tested to assess the sodic pentobarbital induced sleeping-time. To decrease the inflammatory reaction the animals were irradiated with 400 Rad or received azathioprine, 20 mg/kg, 3 times a week, for 4 weeks, respectively in or beginning in the 33th post-infection day. In infected animals receiving azathioprine the area of the hepatic granulomas was smaller and the sleeping-time was similar to that of non-infected ones (controls). In mice infected and irradiated the granuloma dimensions were similar to those of animals only infected, in these two latter groups of animals, the sleeping-time was more prolonged than that of the control animals. These results show that: 1) mice with unaltered hepatic granulomatous reaction show reduction in metabolism of sodic pentobarbital; 2) granulomatous response diminished by azathioprine does not interfere with the capacity of metabolism of the anesthetic drug.
D000818:Animals; D001379:Azathioprine / Q000627:therapeutic use; D005260:Female; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007165:Immunosuppression Therapy; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010424:Pentobarbital / Q000494:pharmacology*; D012555:Schistosomiasis mansoni / Q000188:drug therapy / Q000503:physiopathology* / Q000532:radiotherapy; D012890:Sleep / Q000502:physiology*; D013997:Time Factors
D006993:Hypnotics and Sedatives; D007166:Immunosuppressive Agents; D010424:Pentobarbital; D001379:Azathioprine