title: Microwave influence on the isolated heart function: I. Effect of modulation.
abstract: Dependence of the microwave effect on modulation parameters (pulse width, duty ratio, and peak intensity) was studied in an isolated frog auricle preparation. The rate and amplitude of spontaneous auricle twitches were measured during and after a 2 min exposure to 915 or 885 MHz microwaves and were compared to preexposure values. The studied ranges of modulation parameters were: pulse width, 10(-6)-10(-2) s; duty ratio, 7:100000, and peak specific absorption rate, 100-3000 W/kg. Combinations of the parameters were chosen by chance, and about 400 various exposure regimes were tested. The experiments established that no regime was effective unless the average microwave power was high enough to induce preparation heating (0.1-0.4 degree C). The twitch rate instantly increased, and the amplitude decreased, as the temperature rose; similar changes could be induced by equivalent conventional heating. The data provide evidence that the effect of short-term microwave exposure on the isolated heart pacemaker and contractile functions depends on pulse modulation just as much as modulation determines the average absorbed power. These functions demonstrated no specific dependence on exposure parameters such as frequency or power windows.
mesh_terms: D000818:Animals; D004307:Dose-Response Relationship, Radiation; D006321:Heart / Q000502:physiology* / Q000528:radiation effects; D006339:Heart Rate / Q000528:radiation effects*; D066298:In Vitro Techniques; D008872:Microwaves; D009200:Myocardial Contraction / Q000528:radiation effects*; D011896:Rana temporaria; D013696:Temperature; D013997:Time Factors