[Study on the lung targeting gelatin microspheres of streptomycin sulphate].
This paper is reported the technology of lung targeting gelatin microspheres of streptomycin sulphate (SMS). The microspheres were prepared with natural biodegradable gelatin as the load material and castor oil as the oil phase. The experimental conditions were optimized, the mean volume diameter obtained being 9.7 microns and the mean rate of encapsulation 15.69%. The content, shape and size of the microspheres showed no remarkable change after storage at 37 degrees C RH 75% for 3 months. Activation energy of heat decomposition E = 75.86kJ/mol. In vitro, the SMS release rate was found to accord with Higuchi equation with t1/2 = 8.6h. In vivo (rabbits) the gelatin microspheres were proved to be concentrated in the lung.
D000818:Animals; D016503:Drug Delivery Systems; D005780:Gelatin; D008168:Lung / Q000378:metabolism; D008863:Microspheres; D011817:Rabbits; D013307:Streptomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D014018:Tissue Distribution
D005780:Gelatin; D013307:Streptomycin