Choriocarcinoma presenting as a cutaneous metastasis.
The rare presentation of choriocarcinoma as a cutaneous metastasis in a 23-year-old male is reported. Histological and immunohistochemical analysis of the biopsy material demonstrated two distinct cell populations, syncytiotrophoblasts and cytotrophoblasts, with syncytiotrophoblasts strongly positive for human chorionic gonadotropin antigen. Subsequent clinical evaluation revealed a testicular tumor with metastases to lungs, brain, liver and kidney and increased serum levels of human chorionic gonadotropin. The patient died shortly after diagnosis due to complications of metastatic disease despite chemotherapy.
D000328:Adult; D001932:Brain Neoplasms / Q000556:secondary; D002822:Choriocarcinoma / Q000473:pathology*; D003937:Diagnosis, Differential; D006801:Humans; D007680:Kidney Neoplasms / Q000556:secondary; D008113:Liver Neoplasms / Q000556:secondary; D008175:Lung Neoplasms / Q000556:secondary; D008297:Male; D012878:Skin Neoplasms / Q000473:pathology* / Q000556:secondary*; D013736:Testicular Neoplasms / Q000473:pathology*