[The effect of long-term monotherapy with preparations from the 4 basic groups of antihypertensive agents on the quality of life in patients with mild and moderate arterial hypertension. The Multicenter Captopril and the Quality of Life Study. The working group of the Multicenter Captopril and the Quality of Life Study].
A multicenter, controlled, open, randomized trial of antihypertensive and life quality (LQ) effects of monotherapy with captopril vs propranolol, hydrochlorothiazide and nifedipine included 345 males aged 35-60 years with mild and moderate hypertension. The results of 8-month treatment provided the conclusions: the drugs were much alike by antihypertensive efficacy, LQ parameters proved more beneficial in the group on captopril than those on nifedipine and propranolol, hydrochlorothiazide failed to improve life quality, captopril is an effective and safe antihypertensive drug superior to the drugs of 3 other antihypertensive drug groups by positively affecting LQ.
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001382:Azerbaijan; D002216:Captopril / Q000627:therapeutic use*; D006801:Humans; D006852:Hydrochlorothiazide / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000627:therapeutic use; D011433:Propranolol / Q000627:therapeutic use; D011788:Quality of Life; D012426:Russia; D013223:Statistics as Topic; D014455:Ukraine
D000959:Antihypertensive Agents; D006852:Hydrochlorothiazide; D002216:Captopril; D011433:Propranolol; D009543:Nifedipine
Vliianie dlitel'noĭ monoterapii preparatami iz chetyrekh osnovnykh grupp antigipertenzivnykh sredstv na kachestvo zhizni bol'nykh miagkoĭ i umerennoĭ arterial'noĭ gipertonieĭ. Mnogotsentrovoe issledovanie "Kaptopril i kachestvo zhizni". Rabochaia gruppa mnogotsentrovogo issledovaniia "Kaptopril i kachestvo zhizni".