Induction of Th2 responses in infectious diseases.
Recent work on T-helper (Th) cell subset maturation has focused on defining the cellular source of early IL-4, which promotes precursor (naive) CD4+ Th cells to differentiate into Th type 2 (Th2) cells, and also on the roles of counter-regulatory cytokines, costimulatory signals, and antigen in the induction of Th2 responses. Results suggest that not all Th2 cells are equivalent in their ontogeny.
D000818:Animals; D002454:Cell Differentiation / Q000276:immunology; D007111:Immunity, Cellular; D007239:Infections / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*