title: Vagal control of pyloric resistance.
abstract: Pyloric resistance is probably a major factor regulating gastric emptying of liquids, but its nervous control is unknown. The role of efferent vagal pathways in pyloric resistance was evaluated in 13 anesthetized pigs. Pyloric resistance was assessed by simultaneous recording of gastropyloroduodenal motility and transpyloric flow during gastric emptying of saline. Cervical vagotomy suppressed all antral pressure events, increased the number of pressure events localized at the pylorus, and decreased the frequency of the flow pulses (P < 0.05), without affecting either pyloric resistance or the characteristics of flow pulses. Electrical stimulation of the cervical and the thoracic vagi both decreased pyloric resistance by about 60% and increased the stroke volume of flow pulses (P < 0.05). The reduced pyloric resistance was mainly related to an alteration of the temporal relationship between flow pulses and pyloric pressure events. These results indicate that vagal efferents could provide inhibitory inputs to pyloric resistance. A reduction in pyloric resistance contributes to the increased flow rate observed during vagal stimulation.
mesh_terms: D000818:Animals; D003080:Cold Temperature; D004558:Electric Stimulation; D055590:Electromagnetic Phenomena; D005260:Female; D005746:Gastric Emptying; D005769:Gastrointestinal Motility; D011312:Pressure; D011708:Pylorus / Q000294:innervation / Q000502:physiology*; D012212:Rheology; D013552:Swine; D014628:Vagotomy; D014630:Vagus Nerve / Q000502:physiology*