Kinetics of bioconcentration and clearance of 28 polychlorinated biphenyl congeners in zebrafish (Brachydanio rerio).
Bioconcentration experiments were performed on 28 polychlorinated biphenyl (PCB) congeners with NCl = 2 to NCl = 10, evaluating them simultaneously. Bioconcentration factors (BCFs) were calculated from the uptake rate constant (k1) and the clearance rate constant (k2) as BCF = k1/k2. BCFs on a wet weight basis ranged from 7710 to 940,000. They were correlated with octanol-water partition coefficients (P). The curvilinear relationship between log BCF and log P based upon data covering the log P range 5.06 to 8.18. About a log P of 7.38, a range of "optimal lipophilicity," results in highest BCFs for PCBs, above which the degree of bioconcentration decreases.
Fox
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Fachbereich Chemie, Universität Oldenburg, FRG.
Zauke
G P
GP
Butte
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W
D000818:Animals; D050356:Lipid Metabolism; D011078:Polychlorinated Biphenyls / Q000493:pharmacokinetics*; D015027:Zebrafish / Q000378:metabolism*
D011078:Polychlorinated Biphenyls