Neurotrophic effects of substance P on hippocampal neurons in vitro.
The potential neurotrophic effect of substance P-like immunoreactivity present in culture media was assessed in rat embryonic day 18 hippocampal cultures. The neurokinin-1 (substance P) receptor antagonist CP-96345 induced neurotoxicity that was dose dependent and attenuated by addition of substance P or the neurokinin-1 agonist [Sar9,Met(O2)11]-SP. These studies suggest that under some conditions neurokinin-1 receptor stimulation promotes neuronal survival.
Whitty
C J
CJ
Department of Psychiatry, Wayne State University School of Medicine, Detroit, MI 48201.
Kapatos
G
G
Bannon
M J
MJ
D000818:Animals; D001713:Biphenyl Compounds / Q000494:pharmacology / Q000633:toxicity; D002478:Cells, Cultured; D017077:Culture Media, Conditioned; D006624:Hippocampus / Q000166:cytology* / Q000187:drug effects; D064729:Neurokinin-1 Receptor Antagonists; D009474:Neurons / Q000187:drug effects*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D018040:Receptors, Neurokinin-1 / Q000187:drug effects; D013373:Substance P / Q000494:pharmacology*
D001713:Biphenyl Compounds; D017077:Culture Media, Conditioned; D064729:Neurokinin-1 Receptor Antagonists; D012333:RNA, Messenger; D018040:Receptors, Neurokinin-1; D013373:Substance P; C066892:CP 96345