title: The role of genomic imprinting in implantation.
abstract: OBJECTIVE
  To outline the possible role of the imprinted genes in early human embryogenesis and implantation.
  
  
  METHODS
  Literature review.
  
  
  METHODS
  Studies examining the issues of genomic imprinting, implantation, gestational trophoblastic diseases, placental gene expression, and trophoblast invasion.
  
  
  RESULTS
  Certain genes have been shown to be expressed either in the embryo or in the uterine decidua before implantation. Some of these have been shown to be parentally imprinted, that is, expressed either from their paternal or maternal origin. The paternally expressed genes are linked to placental proliferation and invasiveness.
  
  
  CONCLUSIONS
  Clinical and basic data from different disciplines indicate that genomic imprinting may be crucial to the process of implantation.
authors.affiliation: Silberman Institute of Life Sciences, Hebrew University, Mount Scopus, Jerusalem, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Goshen
authors.forename: Z
authors.initials: Z
authors.lastname: Ben-Rafael
authors.forename: B
authors.initials: B
authors.lastname: Gonik
authors.forename: O
authors.initials: O
authors.lastname: Lustig
authors.forename: V
authors.initials: V
authors.lastname: Tannos
authors.forename: N
authors.initials: N
authors.lastname: de-Groot
authors.forename: A A
authors.initials: AA
authors.lastname: Hochberg
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin / Q000235:genetics; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004303:Dosage Compensation, Genetic; D010064:Embryo Implantation / Q000235:genetics*; D005260:Female; D018392:Genomic Imprinting; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics; D008297:Male; D010446:Peptide Fragments / Q000235:genetics
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D007335:Insulin-Like Growth Factor II