title: Immunohistochemical localization of tyrosine hydroxylase, substance P, neuropeptide-Y and leucine-enkephalin in developing human retinal amacrine cells.
abstract: Prenatal changes in the neurotransmitter/neuromodulator profiles of tyrosine hydroxylase (for dopamine), substance P, neuropeptide Y, and leucine-enkephalin were studied in developing human retinal amacrine cells by the use of immunohistochemical techniques. Tyrosine hydroxylase was localized between 10 and 12 weeks of gestation, substance P and neuropeptide Y appeared little later around 14 weeks, and leucine-enkephalin-like immunoreactivity was observed at 16 weeks.
authors.affiliation: Department of Anatomy (2nd Division), Gifu University School of Medicine, Japan.
authors.forename: G
authors.initials: G
authors.lastname: Jotwani
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: S
authors.initials: S
authors.lastname: Wadhwa
mesh_terms: D004743:Enkephalin, Leucine / Q000276:immunology / Q000378:metabolism*; D005260:Female; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D009478:Neuropeptide Y / Q000276:immunology / Q000378:metabolism*; D011247:Pregnancy; D012160:Retina / Q000166:cytology / Q000254:growth & development* / Q000378:metabolism; D013373:Substance P / Q000276:immunology / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000276:immunology / Q000378:metabolism*
chemical_list: D009478:Neuropeptide Y; D013373:Substance P; D004743:Enkephalin, Leucine; D014446:Tyrosine 3-Monooxygenase