[Immunohistochemical study of neuroendocrine cells and prostate-specific antigen in prostate carcinoma].
In 21 cases of prostate adenocarcinoma and 4 cases of prostate hyperplasia, neuroendocrine (NE) cells were studied immunohistochemically with anti-chromogranin antibody. NE cells were detected in 8 cases (38.8%), in which 4 were found positive for serotonin and 2 for glucagon. 25 cases of prostatic specimens and 7 cases of nonprostatic adenocarcinomas were labelled with prostate-specific antigen (PSA). It was shown that expression of PSA was closely correlated with differentiation of prostatic adenocarcinomas. Reaction of PSA was stronger in well-moderately differentiated adenocarcinoma than in poorly differentiated one. For staining pattern, positive reaction of PSA was located in the apical border in well-moderately differentiated adenocarcinoma, but in the cytoplasm and cell membrane in poorly differentiated one.
Yao
G Y
GY
Department of Pathology, Zhej iang Medical University, Hangzhou.
Lai
M D
MD
Chen
P H
PH
D000230:Adenocarcinoma / Q000737:chemistry*; D000368:Aged; D000369:Aged, 80 and over; D005934:Glucagon / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000032:analysis*; D011471:Prostatic Neoplasms / Q000737:chemistry*; D012701:Serotonin / Q000032:analysis*
D012701:Serotonin; D005934:Glucagon; D017430:Prostate-Specific Antigen