[Clinical and experimental study of benign prostatic hyperplasia with intraglandular injection of chuan shen tong].
1038 cases of benign prostatic hyperplasia (BPH) were treated by injection of Chuan Shen Tong (CST), a Chinese herbal medicine, into the prostate gland. At the end of treatment the effective rate was 96%. After the treatment the BPH with urodynamic measurement was studied and it was found that the peak flow rate and mean flow rate increased 18% and 41.8% respectively. Transabdominal and transrectal ultrasonographies were used to measure the shrinkage of prostate's size after the injection treatment to be 0.51 and 0.4 cm (mean diameter) respectively. Animal model of BPH was established by the testosterone propionate. The prostatic weight and prostatic index was measured in mice after the injection of CST, it significantly decreased compared with that of the control (P < 0.01). The pathological findings: The hyperplastic papillae disappeared and the body of prostate markedly shrank in size. Experiment dogs has been carried out for the prostate quantitative analysis. The result revealed that the prostate parenchyma and intercellular substance shrank to 26.8% and 4.5% respectively.
Zhao
Y J
YJ
91st Hospital of PLA, Yanzhou.
Lu
F N
FN
D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D051379:Mice; D008875:Middle Aged; D011467:Prostate / Q000000981:diagnostic imaging / Q000473:pathology; D011470:Prostatic Hyperplasia / Q000188:drug therapy* / Q000473:pathology; D014463:Ultrasonography; D014563:Urodynamics / Q000187:drug effects
D004365:Drugs, Chinese Herbal