title: Clozapine for early developmental delays with childhood-onset schizophrenia: protocol and 15-month outcome.
abstract: This paper reports on the pharmacotherapy and long-term follow-up of a child treated with clozapine. It is one of the earliest American experiences with this agent in children to date. Clozapine was relatively effective and safe in this patient. Additional features of the case are the early social and developmental delays preceding schizophrenia, the response of symptoms of childhood-onset schizophrenia to clozapine, and the reduction in tardive dyskinesia symptoms while taking clozapine. Compared to recommendations for dosing adults, a slower rate of increasing clozapine doses was important for this child. For future reference, the protocol and consent form used for this course of treatment are included.
authors.affiliation: George Washington University School of Medicine, Washington, DC.
authors.forename: K E
authors.initials: KE
authors.lastname: Towbin
authors.forename: E M
authors.initials: EM
authors.lastname: Dykens
authors.forename: R G
authors.initials: RG
authors.lastname: Pugliese
mesh_terms: D000293:Adolescent; D002648:Child; D003024:Clozapine / Q000009:adverse effects / Q000627:therapeutic use*; D002658:Developmental Disabilities / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D011569:Psychiatric Status Rating Scales; D012561:Schizophrenia, Childhood / Q000188:drug therapy* / Q000523:psychology; D016896:Treatment Outcome
chemical_list: D003024:Clozapine