title: Buprenorphine: duration of blockade of effects of intramuscular hydromorphone.
abstract: Six opioid-dependent in-patients were maintained on daily sublingual doses of buprenorphine at 2, 6, and 12 mg/day for five days at each dose in a randomized, balanced sequence. Placebo buprenorphine was substituted for the next three days, and challenge doses of the mu agonist hydromorphone were administered on the three days. Planned comparisons in a 3-factor ANOVA showed dose-dependent hydromorphone effects, significant blockade of 'high' by the 12 mg buprenorphine dose, and no differences on hydromorphone-induced 'high' across 72 h of active buprenorphine. The data suggest that the blockade by buprenorphine of 'high' persists for at least 72 h after the last dose of buprenorphine.
authors.affiliation: Connecticut Mental Health Center, New Haven 06519.
authors.forename: M I
authors.initials: MI
authors.lastname: Rosen
authors.forename: E A
authors.initials: EA
authors.lastname: Wallace
authors.forename: T J
authors.initials: TJ
authors.lastname: McMahon
authors.forename: H R
authors.initials: HR
authors.lastname: Pearsall
authors.forename: S W
authors.initials: SW
authors.lastname: Woods
authors.forename: L H
authors.initials: LH
authors.lastname: Price
authors.forename: T R
authors.initials: TR
authors.lastname: Kosten
mesh_terms: D000286:Administration, Sublingual; D000328:Adult; D002047:Buprenorphine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D004091:Hydromorphone / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D009293:Opioid-Related Disorders / Q000534:rehabilitation*; D016037:Single-Blind Method; D013375:Substance Withdrawal Syndrome / Q000209:etiology; D013997:Time Factors
chemical_list: D002047:Buprenorphine; D004091:Hydromorphone