title: Peripheral blood stem cell mobilization using high-dose cyclophosphamide and G-CSF in pretreated patients with lymphoma.
abstract: Peripheral blood stem cell (PBSC) mobilization for autologous transplantation is more difficult in treated patients and those with bone marrow involvement. In 17 pretreated lymphoma patients, cyclophosphamide (4 g/m2) and G-CSF mobilized a median circulating peak of 1959 CFU-GM/ml on day 12.5. PBSC harvesting commenced when WBC was 1 x 10(9)/l at day 10.5 collected a median of 21.2 x 10(4)/CFU-GM/kg. 13/17 (76%) patients exceeded the 10 x 10(4) CFU-GM/kg threshold for engraftment. The CFU-GM yield was significantly higher in patients whose WBC recovered from 1-5 x 10(9)/l in less than 3 days and correlated with the maximum WBC pre and post the cyclophosphamide induced nadir. This regime safely mobilized adequate PBSC in the majority of pretreated lymphoma patients.
authors.affiliation: Department of Haematology, Royal Infirmary of Edinburgh, Scotland.
authors.forename: J I
authors.initials: JI
authors.lastname: Craig
authors.forename: R S
authors.initials: RS
authors.lastname: Anthony
authors.forename: A
authors.initials: A
authors.lastname: Stewart
authors.forename: E B
authors.initials: EB
authors.lastname: Thomson
authors.forename: J
authors.initials: J
authors.lastname: Gillon
authors.forename: A C
authors.initials: AC
authors.lastname: Parker
mesh_terms: D000328:Adult; D003520:Cyclophosphamide / Q000494:pharmacology*; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008223:Lymphoma / Q000097:blood* / Q000628:therapy; D008875:Middle Aged; D010976:Platelet Count / Q000187:drug effects
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D003520:Cyclophosphamide