1;17 translocations and other chromosome 17 rearrangements in human primary neuroblastoma tumors and cell lines.
We report on the finding of a t(1;17) in two primary neuroblastomas. Subsequent fluorescence in situ hybridization (FISH) analysis revealed the presence of 1;17 translocations in four out of nine neuroblastoma cell lines. The chromosome 1 short arm breakpoints were determined using region-specific probes. FISH screening also demonstrated or confirmed the presence of 11;17 translocations in three cell lines and other chromosome 17 rearrangements in those cell lines that did not carry a t(1;17) or t(11;17). Our data extend previous cytogenetic findings and suggest that, in addition to the known involvement of chromosome 1, one or more genes on chromosome 17 also play a role in neuroblastoma development.
Van Roy
N
N
Department of Medical Genetics, University Hospital, Gent, Belgium.
Laureys
G
G
Cheng
N C
NC
Willem
P
P
Opdenakker
G
G
Versteeg
R
R
Speleman
F
F
D000310:Adrenal Gland Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary; D001853:Bone Marrow / Q000473:pathology; D001859:Bone Neoplasms / Q000235:genetics / Q000473:pathology / Q000556:secondary; D001932:Brain Neoplasms / Q000235:genetics* / Q000473:pathology; D002460:Cell Line; D002675:Child, Preschool; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002878:Chromosomes, Human, Pair 1; D002886:Chromosomes, Human, Pair 17; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D009447:Neuroblastoma / Q000235:genetics* / Q000473:pathology / Q000556:secondary; D014178:Translocation, Genetic; D014407:Tumor Cells, Cultured