title: The CD19/CD21 signal transduction complex of B lymphocytes.
abstract: CD19 and CD21 are B-cell surface molecules that associate with each other and with CD81 and Leu-13 to generate a signal transduction complex that is independent of the antigen receptor. Current studies, reviewed here by Thomas Tedder, Liang-Ji Zhou and Pablo Engel, indicate an important biological role for this protein complex in the regulation of B-cell development and activation.
authors.affiliation: Dept of Immunology, Duke University Medical Center, Durham, NC 27710.
authors.forename: T F
authors.initials: TF
authors.lastname: Tedder
authors.forename: L J
authors.initials: LJ
authors.lastname: Zhou
authors.forename: P
authors.initials: P
authors.lastname: Engel
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000276:immunology*; D018941:Antigens, CD19; D000943:Antigens, Differentiation / Q000096:biosynthesis / Q000276:immunology; D000944:Antigens, Differentiation, B-Lymphocyte / Q000096:biosynthesis / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D017464:Receptors, Complement 3d / Q000096:biosynthesis / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D018941:Antigens, CD19; D000943:Antigens, Differentiation; D000944:Antigens, Differentiation, B-Lymphocyte; D017464:Receptors, Complement 3d; C062010:leu-13 antigen