Effect of age and sex on copper-induced toxicity in the macular mutant mouse. An animal model for Menkes' kinky-hair disease.
It was determined if the sensitivity in macular mutant mouse to copper-induced toxicity was affected by sex or age. The sensitivity in 6-8-d-old or 3-4-wk-old macular mutant mouse to copper-induced toxicity was not affected by sex. However, 8-9-wk-old mutant females were more sensitive to copper-induced toxicity than mutant males. Furthermore, 6-8-d-old or 3-4-wk-old mutant males were more sensitive to copper-induced toxicity than 8-9-wk-old mutant males. However, age-related differences in sensitivity to copper-induced toxicity did not occur significantly in mutant females. On the other hand, in the case of normal mice, the sensitivity in 6-8-d-old or 3-4-wk-old mice to copper-induced toxicity was not also affected by sex. In contrast to mutant, however, 8-9-wk-old normal males were more sensitive to copper-induced toxicity than 8-9-wk-old normal females. Adult males were also more sensitive to copper-induced toxicity than 6-8-d-old or 3-4-wk-old males. However, age-related differences in sensitivity to copper-induced toxicity did not occur significantly in normal females. These results indicate that sex- and age-related differences in the copper-induced toxicity exist in macular mutant mice.
Shiraishi
N
N
Department of Environmental and Occupational Health, Kochi Medical School, Japan.
Taguchi
T
T
Kinebuchi
H
H
D000375:Aging / Q000473:pathology*; D000818:Animals; D003300:Copper / Q000008:administration & dosage / Q000633:toxicity*; D004195:Disease Models, Animal; D005260:Female; D007279:Injections, Subcutaneous; D008268:Macular Degeneration; D008297:Male; D007706:Menkes Kinky Hair Syndrome / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains; D012737:Sex Factors
D003300:Copper