title: Clinical and immune aspects of idiopathic acute tubulointerstitial nephritis and uveitis syndrome.
abstract: Five patients with idiopathic interstitial nephritis and uveitis without bone marrow granulomas were followed-up for 1 year. Ophthalmological examination revealed bilateral anterior uveitis. Light microscopy of the renal tissue revealed predominant lymphocyte infiltration of the interstitium. Immunohistochemical analysis revealed a clear predominance of memory T lymphocytes (CD45RO+) in the interstitial and tubular infiltration. HLA typing, and immunophenotypic studies of peripheral blood mononuclear cells including absolute lymphocyte and monocyte counts were assessed. The patients' peripheral T-cell subpopulation did not significantly differ from control studies. With steroid treatment maintained during a period of 6-9 months renal function and uveitis responded dramatically in all patients. After 1-year follow-up, only 1 patient showed a relapse of uveitis, but there was complete clinical recovery of the nephritis in all 5 patients. The aim of this study was to describe the 1-year follow-up of 5 new cases of acute tubulointerstitial nephritis and uveitis syndrome, and assess some aspects of their cellular immunity.
authors.affiliation: Nephrology Service, Hospital Ntra Sra del Pino, Las Palmas de Gran Canaria, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Rodriguez-Perez
authors.forename: M
authors.initials: M
authors.lastname: Cruz-Alamo
authors.forename: P
authors.initials: P
authors.lastname: Perez-Aciego
authors.forename: M
authors.initials: M
authors.lastname: Macía-Heras
authors.forename: A
authors.initials: A
authors.lastname: Naranjo-Hernandez
authors.forename: C
authors.initials: C
authors.lastname: Plaza-Toledano
authors.forename: L
authors.initials: L
authors.lastname: Hortal-Cascon
authors.forename: A
authors.initials: A
authors.lastname: Fernandez-Rodriguez
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016130:Immunophenotyping; D007668:Kidney / Q000276:immunology / Q000473:pathology; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D009395:Nephritis, Interstitial / Q000188:drug therapy / Q000276:immunology*; D011241:Prednisone / Q000627:therapeutic use; D013577:Syndrome; D013601:T-Lymphocytes / Q000473:pathology; D014606:Uveitis, Anterior / Q000188:drug therapy / Q000276:immunology*
chemical_list: D011241:Prednisone