Impact of lead pollution on the status of other trace metals in blood and alterations in hepatic functions.
Lead pollution and its impact on the status of four other trace elements--Fe, Zn, Br, and Rb--have been studied in the whole blood samples of different population groups employing energy dispersive X-ray fluorescence technique. These population groups included normal, automobile workers and lead battery manufacturers. The maximum increase in the concentration of trace elements in the blood samples of automobile workers and battery manufacturers was observed for Pb, when compared with normal Pb-B levels. The effect of lead pollution had significantly reduced Zn levels in automobile workers. Fe-B levels in automobile workers had been found to be reduced significantly as compared to control, whereas in battery workers the reduction was not significant. The concentration of Br was greatly enhanced in the blood samples of automobile workers, whereas Rb-B levels were significantly higher in both the automobile and battery workers. Oral administration of lead acetate (100 mg/kg body wt) to experimental rats significantly decreased the activities of hepatic transaminases after 3 and 4 mo of treatment, whereas the activity of hepatic alkaline phosphatase decreased significantly after 4 mo of treatment. It is concluded from this study that higher Pb-B levels greatly influence the levels of other trace elements in human blood samples and also the activities of hepatic transaminases as well as alkaline phosphatase in experimental rats.
Singh
B
B
Biophysics Department, Panjab University, Chandigarh, India.
Dhawan
D
D
Nehru
B
B
Garg
M L
ML
Mangal
P C
PC
Chand
B
B
Trehan
P N
PN
D000284:Administration, Oral; D000328:Adult; D000469:Alkaline Phosphatase / Q000378:metabolism; D000818:Animals; D001966:Bromine / Q000097:blood; D005260:Female; D006801:Humans; D007501:Iron / Q000097:blood; D007854:Lead / Q000097:blood* / Q000633:toxicity; D007855:Lead Poisoning / Q000378:metabolism*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008111:Liver Function Tests; D008297:Male; D009784:Occupational Diseases / Q000378:metabolism*; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D012413:Rubidium / Q000097:blood; D013052:Spectrometry, X-Ray Emission; D014131:Trace Elements / Q000097:blood*; D000637:Transaminases / Q000378:metabolism; D015032:Zinc / Q000097:blood
D009942:Organometallic Compounds; D014131:Trace Elements; D007854:Lead; D007501:Iron; D000637:Transaminases; D000469:Alkaline Phosphatase; D015032:Zinc; D012413:Rubidium; C008261:lead acetate; D001966:Bromine