Effects of chronic brofaromine administration on biogenic amines including sulphatoxymelatonin and acid metabolites in patients with bulimia nervosa.
Brofaromine, a selective and reversible inhibitor of monoamine oxidase-A (MAO-A) was given to 19 women while 17 received placebo for 8 weeks. All met DSM III-R criteria for bulimia nervosa, a psychiatric disorder in which uncontrolled overeating episodes are accompanied by purging activities and extreme concerns about body shape and weight. The following indices were measured: plasma and urinary phenylacetic acid (PAA), homovanillic acid (HVA), vanillylmandellic acid (VMA); plasma tryptamine (T), beta phenylethylamine (PE), and 5-hydroxyindoleacetic acid (5-HIAA) and urinary 6-sulphatoxymelatonin (aMT6s). PE levels remained the same but T showed a trend toward elevation over time. Twenty-four hour levels of urinary aMT6s in BN patients were higher at week 4 when compared to baseline and week 8. There was a significant reduction in plasma VMA and HVA over time during treatment with brofaromine and both plasma HVA and VMA were significantly lower for the brofaromine group compared to placebo at week 4. Plasma 5-HIAA was significantly higher for the brofaromine group after 8 weeks when compared to placebo. Urinary VMA decreased significantly from baseline to week 4 with a partial elevation at 8 weeks. Urinary VMA was also significantly lower in patients on brofaromine at week 4. This study verifies that brofaromine complies with predicted MAO-A inhibiting patterns in a clinical population.
Kennedy
S H
SH
Department of Psychiatry, University of Toronto, Ontario, Canada.
Davis
B A
BA
Brown
G M
GM
Ford
C G
CG
d'Souza
J
J
D000293:Adolescent; D000328:Adult; D001679:Biogenic Amines / Q000378:metabolism*; D002032:Bulimia / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D006719:Homovanillic Acid / Q000097:blood / Q000652:urine; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D008550:Melatonin / Q000031:analogs & derivatives* / Q000378:metabolism / Q000652:urine; D008996:Monoamine Oxidase Inhibitors / Q000627:therapeutic use*; D010880:Piperidines / Q000627:therapeutic use*; D014363:Tryptamines / Q000652:urine; D014642:Vanilmandelic Acid / Q000097:blood / Q000652:urine
D001679:Biogenic Amines; D008996:Monoamine Oxidase Inhibitors; D010880:Piperidines; D014363:Tryptamines; C054513:6-sulfatoxymelatonin; C030820:tryptamine; D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; C038213:brofaromine; D008550:Melatonin; D006719:Homovanillic Acid