Stimulation of alveolar macrophages by BCG vaccine enhances the process of lung fibrosis induced by bleomycin.
It was found that the BCG vaccine injected subcutaneously to the rats enhances the process of lung fibrosis induced by bleomycin. Pretreatment of rats with this vaccine results in accumulation of activated macrophages in lung interstitium and in the bronchoalveolar spaces. It may be suggested that the activated macrophages release various cytokines which may stimulate the proliferation of fibroblasts and biosynthesis of extracellular matrix components.
Chyczewska
E
E
Department of Pulmonary Diseases and Tuberculosis, Academy of Medicine, Białystok, Poland.
Chyczewski
L
L
Bańkowski
E
E
Sułkowski
S
S
Nikliński
J
J
D000818:Animals; D001500:BCG Vaccine / Q000494:pharmacology*; D001761:Bleomycin / Q000633:toxicity*; D008168:Lung / Q000473:pathology; D008262:Macrophage Activation; D016676:Macrophages, Alveolar / Q000502:physiology*; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000473:pathology; D051381:Rats; D017208:Rats, Wistar
D001500:BCG Vaccine; D001761:Bleomycin