Deletion of 3p25-->pter in a primary follicular thyroid carcinoma and its metastasis.
We report the cytogenetic analysis of a follicular thyroid carcinoma and its bone metastasis. Both lesions had identical chromosomal abnormalities, with a der(3)t(2;3)(q13;p25) as the most likely primary clonal alteration. Our findings corroborate previous observations of frequent 3p deletions in thyroid follicular carcinomas and suggest that the minimal chromosomal region of loss in these tumors is 3p25-->pter.
Roque
L
L
Institute for Molecular Pathology and Immunology, University of Porto-IPATIMUP, Portugal.
Castedo
S
S
Clode
A
A
Soares
J
J
D018263:Adenocarcinoma, Follicular / Q000235:genetics* / Q000556:secondary; D000368:Aged; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D007621:Karyotyping; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000556:secondary; D014407:Tumor Cells, Cultured