Effect of beta-sitosterol on uterine biochemistry: a comparative study with estradiol and progesterone.
Administration of estradiol/progesterone to ovariectomized animals significantly increased the uterine weight, RNA, DNA and protein concentrations. Similarly, administration of beta-sitosterol alone or in combination with estradiol caused a marked increase in the above parameters and the maximum influence was evident only after median and high dose treatments. However, administration of median/high dose of beta-sitosterol along with progesterone accentuated only the RNA and protein concentrations but exerted an inhibitory effect on sitosterol-induced increment in uterine weight and DNA concentrations.
Malini
T
T
Department of Endocrinology, Dr. ALM Post Graduate Institute of Basic Medical Sciences, Taramani, Madras, India.
Vanithakumari
G
G
D000818:Animals; D004247:DNA / Q000187:drug effects; D004958:Estradiol / Q000494:pharmacology*; D004967:Estrogens / Q000494:pharmacology*; D004968:Estrogens, Non-Steroidal; D005260:Female; D007529:Isoflavones; D009929:Organ Size / Q000187:drug effects; D010052:Ovariectomy; D048789:Phytoestrogens; D028321:Plant Preparations; D011374:Progesterone / Q000494:pharmacology*; D011506:Proteins / Q000187:drug effects; D012313:RNA / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012855:Sitosterols / Q000494:pharmacology*; D014599:Uterus / Q000033:anatomy & histology / Q000737:chemistry / Q000187:drug effects*
D004967:Estrogens; D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations; D011506:Proteins; D012855:Sitosterols; D011374:Progesterone; D004958:Estradiol; C025473:gamma-sitosterol; D012313:RNA; D004247:DNA