[Protease inhibitors as immunomodulators in experimental acute pancreatitis and staphylococcal infection].
The influence of protease-inhibiting preparations on the development of humoral immune response in diseases involving the development of secondary immunodeficiency (experimentally induced acute pancreatitis and staphylococcal infection) has been studied. Five injections of contrycal and epsilon-aminocaproic acid (epsilon-ACA), starting from day 1 after the induction of acute pancreatitis, normalized the immune response induced by sheep red blood cells 24 hours after operation. In staphylococcal infection protease-inhibiting preparations (contrycal, epsilon-ACA, Amben) produced a protective effect, increasing the survival rate and the mean survival time of the animals infected with staphylococci.
Chalyĭ
G A
GA
Prokopenko
L G
LG
Latysh
N A
NA
D010129:4-Aminobenzoic Acid / Q000627:therapeutic use; D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D015119:Aminocaproic Acid / Q000627:therapeutic use; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D007611:Aprotinin / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010195:Pancreatitis / Q000188:drug therapy* / Q000276:immunology / Q000401:mortality; D011480:Protease Inhibitors / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D013203:Staphylococcal Infections / Q000188:drug therapy* / Q000276:immunology / Q000401:mortality; D013997:Time Factors; D062366:para-Aminobenzoates
D000276:Adjuvants, Immunologic; D011480:Protease Inhibitors; D062366:para-Aminobenzoates; C015668:4-aminomethylbenzoic acid; D007611:Aprotinin; D010129:4-Aminobenzoic Acid; D015119:Aminocaproic Acid