A mouse Y chromosome gene encoded by a region essential for spermatogenesis and expression of male-specific minor histocompatibility antigens.
A new mouse Y chromosome gene, Smcy, has been isolated from the region encoding Spy, a spermatogenesis gene and Hya and Sdma, the genes that, respectively, control the expression of the male specific minor histocompatibility antigen H-Y, as measured by specific T-cell assays and the serologically detected male antigen SDMA. Smcy is well conserved on the Y in mouse, man and even marsupials. It is expressed in all adult male tissues tested and can also be detected during mouse development from as early as two cells. In addition, its human Y homologue, SMCY, is expressed in multiple tissues and maps to the same Yq deletion interval as the human H-Y antigen controlling locus, HY.
Agulnik
A I
AI
Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103.
Mitchell
M J
MJ
Lerner
J L
JL
Woods
D R
DR
Bishop
C E
CE
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D004247:DNA / Q000235:genetics; D017931:DNA Primers; D005260:Female; D015870:Gene Expression / Q000235:genetics*; D006182:H-Y Antigen / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008297:Male; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction / Q000379:methods; D012194:RNA-Directed DNA Polymerase; D015183:Restriction Mapping; D017384:Sequence Deletion; D017386:Sequence Homology, Amino Acid; D012727:Sex Characteristics; D013091:Spermatogenesis / Q000235:genetics*; D013737:Testis / Q000378:metabolism; D014998:Y Chromosome
D017931:DNA Primers; D006182:H-Y Antigen; D004247:DNA; D012194:RNA-Directed DNA Polymerase