title: Histological, histochemical and ultrastructural features of hyaline inclusions in hepatocytes of striped dolphins (Stenella coeruleoalba).
abstract: Many striped dolphins (Stenella coeruleoalba) which died in the recent morbillivirus epizootic in the Mediterranean Sea had hyaline inclusions in hepatocytes. We investigated the histological, histochemical and ultrastructural features of these inclusions in two affected dolphins. Histochemical tests indicated that they contained glycoprotein but not lipid. Ultrastructurally, they consisted of granular, moderately electron-dense material, bounded by a membrane. A central or eccentric core of highly electron-dense material was usually apparent. The inclusions were probably of lysosomal origin.
authors.affiliation: Department of Pathology, Department of Agriculture for Northern Ireland, Stormont, Belfast.
authors.forename: S
authors.initials: S
authors.lastname: Kennedy
authors.forename: G
authors.initials: G
authors.lastname: Di Guardo
authors.forename: S
authors.initials: S
authors.lastname: McConnell
authors.forename: D
authors.initials: D
authors.lastname: Moffett
authors.forename: U
authors.initials: U
authors.lastname: Agrimi
mesh_terms: D000820:Animal Diseases / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology; D000818:Animals; D000956:Antigens, Viral / Q000032:analysis; D001996:Bronchopneumonia / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology / Q000662:veterinary; D004196:Disease Outbreaks / Q000662:veterinary; D004289:Dolphins / Q000033:anatomy & histology*; D006023:Glycoproteins / Q000032:analysis; D006524:Hepatitis, Viral, Animal / Q000453:epidemiology / Q000382:microbiology / Q000473:pathology*; D002479:Inclusion Bodies / Q000737:chemistry / Q000648:ultrastructure*; D007558:Italy / Q000453:epidemiology; D008099:Liver / Q000473:pathology*; D008168:Lung / Q000473:pathology; D008247:Lysosomes / Q000648:ultrastructure; D008522:Mediterranean Sea; D018103:Morbillivirus / Q000276:immunology / Q000302:isolation & purification; D018185:Morbillivirus Infections / Q000453:epidemiology / Q000473:pathology / Q000662:veterinary*; D010503:Periodic Acid-Schiff Reaction; D011078:Polychlorinated Biphenyls / Q000009:adverse effects; D013194:Staining and Labeling
chemical_list: D000956:Antigens, Viral; D006023:Glycoproteins; D011078:Polychlorinated Biphenyls