Cutaneous T-cell lymphoma with massive co-infiltration of polyclonal B cells.
A 76-year-old man presented with a 3-month history of a cutaneous nodule on the right thigh. The tumour was composed of CD3+, large atypical cells, and CD20+, small normal-appearing cells. Flow cytometry showed that CD20+ cells outnumbered CD3+ cells. By Southern blot hybridization analyses, the malignant cells were shown to be of T-cell origin, because of the presence of rearranged bands for the beta chain of the T-cell receptor, but not for the immunoglobulin heavy chain. This case represents a T-cell lymphoma intermingled with a large number of non-neoplastic B cells.
Yagi
H
H
Department of Dermatology, Hamamatsu University School of Medicine, Japan.
Ogai
M
M
Izumi
T
T
Ebihara
T
T
Sugiura
M
M
Tokura
Y
Y
Takigawa
M
M
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D018951:Antigens, CD20; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology*; D015139:Blotting, Southern; D017252:CD3 Complex / Q000032:analysis; D006801:Humans; D016130:Immunophenotyping; D007866:Leg; D016399:Lymphoma, T-Cell / Q000276:immunology / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000276:immunology / Q000473:pathology*
D015703:Antigens, CD; D018951:Antigens, CD20; D000944:Antigens, Differentiation, B-Lymphocyte; D017252:CD3 Complex