title: [The biological activity of saparal in an influenzal infection].
abstract: The antiviral and interferon-inducing activity of saparal, an adaptogen of plant origin, was studied. Tests in experimental mice demonstrated the interferon-inducing activity of saparal providing its antiviral effect. An optimal scheme of saparal administration was developed. The preparation had no direct inhibitory effect on influenza virus replication. The application of saparal for prophylaxis among workers resulted in a 2-fold or greater decrease of influenza and other ARD morbidity and in an increase of endogenous serum interferon level in 67-75% of the persons examined.
authors.forename: M S
authors.initials: MS
authors.lastname: Paramonova
authors.forename: V M
authors.initials: VM
authors.lastname: Gagarinova
authors.forename: M A
authors.initials: MA
authors.lastname: Rodina
authors.forename: V M
authors.initials: VM
authors.lastname: Guseva
authors.forename: V V
authors.initials: VV
authors.lastname: Burmistrova
authors.forename: Z A
authors.initials: ZA
authors.lastname: Osipova
authors.forename: O A
authors.initials: OA
authors.lastname: Aksenov
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000627:therapeutic use*; D002478:Cells, Cultured; D002642:Chick Embryo; D004341:Drug Evaluation; D004353:Drug Evaluation, Preclinical; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects; D007251:Influenza, Human / Q000097:blood / Q000188:drug therapy* / Q000453:epidemiology / Q000517:prevention & control; D007369:Interferon Inducers / Q000627:therapeutic use*; D007372:Interferons / Q000097:blood / Q000187:drug effects; D051379:Mice; D010936:Plant Extracts / Q000627:therapeutic use*; D012426:Russia / Q000453:epidemiology; D012621:Seasons
chemical_list: D000998:Antiviral Agents; D007369:Interferon Inducers; D010936:Plant Extracts; C057659:saparal; D007372:Interferons