Buprenorphine: duration of blockade of effects of intramuscular hydromorphone.
Six opioid-dependent in-patients were maintained on daily sublingual doses of buprenorphine at 2, 6, and 12 mg/day for five days at each dose in a randomized, balanced sequence. Placebo buprenorphine was substituted for the next three days, and challenge doses of the mu agonist hydromorphone were administered on the three days. Planned comparisons in a 3-factor ANOVA showed dose-dependent hydromorphone effects, significant blockade of 'high' by the 12 mg buprenorphine dose, and no differences on hydromorphone-induced 'high' across 72 h of active buprenorphine. The data suggest that the blockade by buprenorphine of 'high' persists for at least 72 h after the last dose of buprenorphine.
Rosen
M I
MI
Connecticut Mental Health Center, New Haven 06519.
Wallace
E A
EA
McMahon
T J
TJ
Pearsall
H R
HR
Woods
S W
SW
Price
L H
LH
Kosten
T R
TR
D000286:Administration, Sublingual; D000328:Adult; D002047:Buprenorphine / Q000008:administration & dosage* / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D004091:Hydromorphone / Q000008:administration & dosage / Q000009:adverse effects / Q000037:antagonists & inhibitors*; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects; D009293:Opioid-Related Disorders / Q000534:rehabilitation*; D016037:Single-Blind Method; D013375:Substance Withdrawal Syndrome / Q000209:etiology; D013997:Time Factors
D002047:Buprenorphine; D004091:Hydromorphone