Effects of single intravenous administration of urapidil and diltiazem in patients with nonfixed pulmonary hypertension secondary to chronic obstructive lung disease.
In patients with chronic obstructive lung disease (COLD), pulmonary hypertension (PH) often develops in addition over the course of years. In this study, the acute effects of urapidil and diltiazem in patients with mild PH secondary to COLD were investigated. Eighteen male and 2 female patients, aged 42-78 years, received in randomized, single-blind fashion single intravenous (i.v.) doses of either urapidil (35-50 mg, n = 10) or diltiazem (25 mg, n = 10). Mean pulmonary artery pressure (MPAP), pulmonary wedge pressure (PWP), mean arterial blood pressure (BP) (MAP), and arterial and central venous blood gases were determined at rest and during exercise (starting with 25 W with increases in 25-W steps) before and after drug administration. Urapidil caused a significant reduction in MPAP (from 19 +/- 7 to 15 +/- 4 mm Hg, p < 0.01), PWP (from 9 +/- 3 to 7 +/- 2 mm Hg, p < 0.05), but not significantly in MAP at rest, whereas with diltiazem only MAP was decreased (from 103 +/- 14 to 98 +/- 12 mm Hg, p < 0.05) and MPAP and PWP were not significantly increased.(ABSTRACT TRUNCATED AT 250 WORDS)
Späh
F
F
Department of Internal Medicine I (Cardiology), City Hospital, Konstanz, Germany.
Kottman
R
R
Schmidt
U
U
D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage* / Q000494:pharmacology; D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000008:administration & dosage* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D004110:Diltiazem / Q000008:administration & dosage* / Q000494:pharmacology; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000188:drug therapy* / Q000209:etiology; D007275:Injections, Intravenous; D008173:Lung Diseases, Obstructive / Q000150:complications*; D008297:Male; D008875:Middle Aged; D010879:Piperazines / Q000008:administration & dosage* / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects; D011669:Pulmonary Wedge Pressure / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents; D010879:Piperazines; C015568:urapidil; D004110:Diltiazem