Paraganglioma of the lung--developed after exposure to nuclear radiation by the Tschernobyl atomic reactor accident?
A 36-year-old Russian patient had been exposed to severe nuclear radiation during the Tschernobyl accident and developed Cushing's syndrome in September 1991. After bilateral adrenalectomy a small centrally localized lung tumor in the left segment S6 was diagnosed, and the syndrome was correlated to primary lung cancer. Thoracotomy and resection of the segments S6 revealed a primary ACTH-producing lung tumor of the cell type of a paraganglioma. The patient lost his symptoms after curative tumor resection. The case is discussed under the aspects of tumor etiology, its clinical course and immunohistochemical findings.
Hagemeyer
O
O
Department of Pathology, Thoraxklinik, Heidelberg.
Gabius
H J
HJ
Kayser
K
K
D000324:Adrenocorticotropic Hormone / Q000032:analysis; D000328:Adult; D003480:Cushing Syndrome / Q000209:etiology; D006801:Humans; D007633:Keratins / Q000032:analysis; D008175:Lung Neoplasms / Q000209:etiology* / Q000473:pathology; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D010235:Paraganglioma / Q000209:etiology* / Q000473:pathology; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D011210:Power Plants; D018788:Radioactive Hazard Release; D016159:Tumor Suppressor Protein p53 / Q000032:analysis; D014455:Ukraine; D014746:Vimentin / Q000032:analysis
D016159:Tumor Suppressor Protein p53; D014746:Vimentin; D007633:Keratins; D000324:Adrenocorticotropic Hormone; D010751:Phosphopyruvate Hydratase