Regional oxygen consumption persists in dyskinetic canine myocardium.
Regional myocardial O2 consumption was measured in anesthetized dogs both in baseline conditions and during intracoronary infusion of lidocaine, verapamil, sodium citrate, or 2,3-butanedione-monoxime (BDM). Despite regional hypokinesis and dyskinesis during drug infusion, regional O2 consumption was reduced only 30-40% by lidocaine, verapamil, and citrate and not at all by BDM. These results cast doubt on an important assumption of the "hibernation" theory: the protective matching of regional perfusion and contraction.
Buffington
C W
CW
Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, Pennsylvania.
Strum
D P
DP
Watanabe
S
S
D000818:Animals; D001794:Blood Pressure; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002951:Citrates / Q000494:pharmacology; D003326:Coronary Circulation; D003931:Diacetyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D004285:Dogs; D006339:Heart Rate; D007261:Infusions, Intra-Arterial; D008012:Lidocaine / Q000494:pharmacology; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000517:prevention & control*; D010101:Oxygen Consumption / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology
D002121:Calcium Channel Blockers; D002951:Citrates; C004717:diacetylmonoxime; D008012:Lidocaine; D014700:Verapamil; D003931:Diacetyl