[The effect of staphylococcal peptidoglycan on macrophage interferon formation and bactericidal activity].
Staphylococcus aureus cell-wall peptidoglycan has been shown to stimulate the bactericidal activity of peritoneal exudate macrophages. A more pronounced activating effect of peptidoglycan on the bactericidal activity of macrophages has been detected in the stimulated test. Peptidoglycan in doses of 5-100 mg induced interferon production by intact mouse splenocytes after 24-hour exposition with it. Peptidoglycan has been found to produce the most intensive effect on interferon production when injected intraperitoneally in a dose of 100 mg after 4-hour exposition.
Pozur
V K
VK
Rashevskaia
E V
EV
Lazarenko
L N
LN
Krivokhatskaia
L D
LD
Spivak
N Ia
NIa
D000818:Animals; D002473:Cell Wall; D004305:Dose-Response Relationship, Drug; D007369:Interferon Inducers / Q000494:pharmacology*; D007372:Interferons / Q000096:biosynthesis / Q000187:drug effects*; D017737:Macrophages, Peritoneal / Q000187:drug effects* / Q000276:immunology; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010457:Peptidoglycan / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects; D013211:Staphylococcus aureus; D013268:Stimulation, Chemical
D007369:Interferon Inducers; D010457:Peptidoglycan; D007372:Interferons