title: Comparative study of hepatitis C virus antibody between hemodialysis and continuous ambulatory peritoneal dialysis patients.
abstract: We have done cross sectional and prospective studies to determine the prevalence and the clinical significance of antibodies to the hepatitis C virus (Anti-HCV) in 54 hemodialysis (HD) patients and 227 continuous ambulatory peritoneal dialysis (CAPD) patients. Fifteen patients (27.8%) were anti-HCV (+) among the HD group, and twelve patients (5.3%) were anti-HCV (+) among the CAPD group. In the HD group, the positivity of anti-HCV correlated with the duration of HD, but there was no significant correlation with the history of transfusion, the amount of transfusion and abnormal alanine aminotransferase (ALT). At the follow-up study in 164 cases (HD 50 cases, CAPD 114 cases) after 6 months, one of 14 anti-HCV (+) CAPD patients was converted to anti-HCV (-) and two of 35 anti-HCV (-) HD patients were converted to anti-HCV (+). In conclusion, the prevalence of anti-HCV was significantly higher in HD patients compared to CAPD patients, and the positivity for anti-HCV in HD patients correlated with the duration of HD. A regular follow-up of anti-HCV and isolation of anti-HCV (+) HD patients with a separate machine may be needed to prevent the transmission of the hepatitis C virus during hemodialysis.
authors.affiliation: Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea.
authors.forename: H Y
authors.initials: HY
authors.lastname: Lee
authors.forename: D H
authors.initials: DH
authors.lastname: Kang
authors.forename: C S
authors.initials: CS
authors.lastname: Park
authors.forename: K Y
authors.initials: KY
authors.lastname: Kim
authors.forename: S W
authors.initials: SW
authors.lastname: Kang
authors.forename: H S
authors.initials: HS
authors.lastname: Kim
authors.forename: K H
authors.initials: KH
authors.lastname: Choi
authors.forename: S K
authors.initials: SK
authors.lastname: Ha
authors.forename: D S
authors.initials: DS
authors.lastname: Han
mesh_terms: D000328:Adult; D003430:Cross-Sectional Studies; D005260:Female; D016174:Hepacivirus / Q000276:immunology; D006508:Hepatitis Antibodies / Q000032:analysis*; D018937:Hepatitis C Antibodies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D011446:Prospective Studies; D006435:Renal Dialysis
chemical_list: D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies