title: Patterns of antibodies to hepatitis C virus and hepatitis C virus replication in children with chronic non-A, non-B hepatitis.
abstract: Antibodies to hepatitis C virus (HCV), investigated by second- and third-generation assays, were detected in 74% of 43 children with chronic non-A, non-B hepatitis. The polymerase chain reaction identified HCV ribonucleic acid in 26 (93%) of 28 seropositive and in 1 of 10 seronegative cases. Intermittent HCV ribonucleic acid positivity, suggesting low and fluctuating viremia, was frequent in younger patients.
authors.affiliation: Pediatric Clinic, 2nd Faculty, Naples, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Bortolotti
authors.forename: P
authors.initials: P
authors.lastname: Vajro
authors.forename: C
authors.initials: C
authors.lastname: Barbera
authors.forename: C
authors.initials: C
authors.lastname: Crivellaro
authors.forename: L
authors.initials: L
authors.lastname: Zancan
authors.forename: R
authors.initials: R
authors.lastname: Giacchino
authors.forename: G
authors.initials: G
authors.lastname: Nebbia
authors.forename: L
authors.initials: L
authors.lastname: Lepore
authors.forename: E
authors.initials: E
authors.lastname: Barbierato
authors.forename: L
authors.initials: L
authors.lastname: De Moliner
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification* / Q000502:physiology; D006508:Hepatitis Antibodies / Q000032:analysis*; D006526:Hepatitis C / Q000235:genetics / Q000276:immunology / Q000821:virology*; D018937:Hepatitis C Antibodies; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D014766:Viremia / Q000235:genetics / Q000276:immunology / Q000821:virology*; D014779:Virus Replication
chemical_list: D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D012367:RNA, Viral