In vivo effect of chlorophyllin on gamma-ray-induced sister chromatid exchange in murine bone marrow cells.
The aim of the present work is to determine the radioprotective capacity of chlorophyllin, by measuring the reduction of gamma-ray-induced sister-chromatid exchange (SCE) in murine bone marrow cells in vivo. The results obtained in two separate experiments, using 10, 50 and 100 micrograms of chlorophyllin per g of body weight (bw), indicate that chlorophyllin per se did not have any effect on the SCE frequency and that the dose of 100 micrograms/g bw protects 100% against the induction of SCE by 1.0 Gy of gamma-rays; 50 micrograms/g bw protects less than 50% and 10 micrograms/g bw affords no protection.
Morales-Ramírez
P
P
Instituto Nacional de Investigaciones Nucleares, Mexico, D.F.
García-Rodríguez
M C
MC
D000818:Animals; D016587:Antimutagenic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D001835:Body Weight; D001853:Bone Marrow / Q000528:radiation effects; D002735:Chlorophyllides / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D016587:Antimutagenic Agents; D002735:Chlorophyllides; C007020:chlorophyllin