Carboplatin treatment induces dose-dependent increases in the frequency of micronuclei in Ehrlich ascites tumor cells.
The effect of various doses (75-300 mg/kg b.w.) of carboplatin on the induction of micronuclei in Ehrlich ascites tumor (EAT) cells was studied. Carboplatin treatment resulted in a dose-dependent increase in the frequency of micronucleated EAT cells. Carboplatin treatment also decreased the mitotic index. The dose-effect curves were linear-quadratic for all the parameters studied. The maximal effect of the drug was obtained in all the treatments after 48 h.
Quintana
E
E
Deparmento de Biología Animal, Facultad de Ciencias Biológicas, Universidad de Valencia, Spain.
Pertusa
J
J
González
R
R
Renau-Piqueras
J
J
D000818:Animals; D016190:Carboplatin / Q000633:toxicity*; D002286:Carcinoma, Ehrlich Tumor; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D014407:Tumor Cells, Cultured
D009153:Mutagens; D016190:Carboplatin