Granulocyte colony-stimulating factor enhances the expression of CD62 on platelets in vivo.
The expression of CD41, CD42 and CD62 on platelets was determined in ten patients with and without G-CSF treatment. CD41 and CD42 is expressed in nearly 100% of the platelets without change after G-CSF treatment. The expression of CD62 on the platelets' surface is significantly enhanced by G-CSF indicating a depletion of the alpha-granules. No platelet aggregation was observed. The enhanced secretion of thrombocyte-specific proteins does not induce aggregation but may promote ADP-induced aggregation. Furthermore, the surface-bound and soluble CD62 binds specifically to macrophages and endothelial cells and is involved in the regulation of inflammatory processes. Thus indirect mechanisms may supplement direct effects of G-CSF after chemotherapy.
Avenarius
H J
HJ
Abteilung Hämatologie und Onkologie, Medizinische Hochschule Hannover, Germany.
Freund
M
M
Kleine
H D
HD
Heussner
P
P
Poliwoda
H
H
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006801:Humans; D008297:Male; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins / Q000097:blood*
D015703:Antigens, CD; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor