A test of brain electrical source analysis (BESA): a simulation study.
The present report summarizes the results of a simulation study on the accuracy of Scherg's implementation of spatio-temporal analysis (BESA) for estimating the parameters (wave shape, location, orientation) of the intracranial sources of event-related brain potentials (ERPs) recorded from the scalp. In view of the subjective factors that might influence a solution, 10 subjects, ranging from those with much experience with ERPs and extensive background in the use of BESA to those with little experience with BESA and/or no knowledge of ERPs, independently analyzed a set of simulated somatosensory ERP data. The simulation contained wave forms from 32 electrode sites generated by a combination of 10 dipole sources. The primary question was how faithfully the different subjects would depict the source wave shapes, locations and orientations. Based on the 9 subjects who were familiar with ERPs, the grand-average cross-correlation coefficient between subjects' estimated and actual source wave shapes was 0.89 (standard deviation (S.D.) = 0.17). The grand-average location error, based upon a head diameter of 17 cm, was 1.4 cm (S.D. = 1.0 cm). The grand-average orientation error was 24.4 degrees (S.D. = 20 degrees).
Miltner
W
W
Department of Medical Psychology, University of Tübingen, FRG.
Braun
C
C
Johnson
R
R
Simpson
G V
GV
Ruchkin
D S
DS
D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D003198:Computer Simulation; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D006801:Humans; D008959:Models, Neurological; D009949:Orientation / Q000502:physiology; D011930:Reaction Time / Q000502:physiology