title: A placebo-controlled trial of isoprinosine in patients with multiple sclerosis.
abstract: Isoprinosine was used under double-blind, randomised, and placebo-controlled conditions in 52 patients with relapsing/remitting or progressive multiple sclerosis. All patients received pulsed treatment with methylprednisolone. There was no significant effect of treatment on clinical disability or the accumulation of MRI abnormalities, after correction of results for multiple comparisons. It is concluded that isoprinosine is not effective therapy for multiple sclerosis.
authors.affiliation: Department of Neurology, University Hospital of Wales, Heath Park, Cardiff, UK.
authors.forename: N M
authors.initials: NM
authors.lastname: Milligan
authors.forename: D H
authors.initials: DH
authors.lastname: Miller
authors.forename: D A
authors.initials: DA
authors.lastname: Compston
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000704:Analysis of Variance; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007542:Inosine Pranobex / Q000008:administration & dosage / Q000627:therapeutic use*; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000188:drug therapy* / Q000473:pathology; D012008:Recurrence; D016896:Treatment Outcome
chemical_list: D007542:Inosine Pranobex