title: The relationship of uterine and umbilical Doppler resistance to fetal and placental protein synthesis in the second trimester.
abstract: The relation of uteroplacental and umbilical Doppler resistance index (RI) to peripheral levels of alphafetoprotein (AFP), human chorionic gonadotrophin (hCG), human placental lactogen (HPL), Schwangerswaft protein (SP1), pregnancy-associated placental protein A (PAPP-A) and insulin-like growth factor binding protein 1 (IGP-BP1) at 16-24 weeks was established in a cross-sectional study of 183 unselected singleton pregnancies. There was an association between high values of uteroplacental RI and high hCG levels, and high umbilical RI values with high hCG and HPL levels. Thus, in the mid-trimester, the levels of some placental proteins seem to be related to placental resistance.
authors.affiliation: Department of Obstetrics and Gynaecology, University College and Middlesex School of Medicine, London, UK.
authors.forename: S
authors.initials: S
authors.lastname: Bewley
authors.forename: T
authors.initials: T
authors.lastname: Chard
authors.forename: G
authors.initials: G
authors.lastname: Grudzinskas
authors.forename: S
authors.initials: S
authors.lastname: Campbell
mesh_terms: D002352:Carrier Proteins / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood; D005260:Female; D005312:Fetal Blood / Q000378:metabolism; D005333:Fetus / Q000098:blood supply / Q000378:metabolism*; D005865:Gestational Age; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1; D010920:Placenta / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000378:metabolism*; D010928:Placental Lactogen / Q000097:blood; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000096:biosynthesis*; D011266:Pregnancy-Associated Plasma Protein-A / Q000378:metabolism; D016216:Ultrasonography, Prenatal; D014472:Umbilicus / Q000000981:diagnostic imaging; D014599:Uterus / Q000098:blood supply / Q000000981:diagnostic imaging; D014655:Vascular Resistance; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D006063:Chorionic Gonadotropin; D018970:Insulin-Like Growth Factor Binding Protein 1; D011257:Pregnancy Proteins; D000509:alpha-Fetoproteins; D010928:Placental Lactogen; D011266:Pregnancy-Associated Plasma Protein-A