[In vitro modification of plasma viscosity and erythrocyte aggregation by four plasma substitutes].
We tested the haemorheological effects of the addition of 3.5% oxypolygelatine, 10% dextran 40, 6% dextran 75 or 5% albumin, respectively, to fresh donor blood of 25 healthy young persons. We examined the aggregation and the viscosity of substituent plasma mixtures in such various, but constant volume relations as may be present during intravenous infusion. Albumin reduced viscosity and aggregation, but especially dextran 75 increased both parameters significantly.
Brehme
S
S
Abteilung für Kardiologie, Angiologie, Pulmologie und Nephrologie, Humboldt-Universität zu Berlin, Chartié.
Keysser
G
G
Turowski
A
A
Schmidt
H H
HH
Lerche
D
D
D000328:Adult; D001809:Blood Viscosity / Q000187:drug effects*; D003911:Dextrans / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004903:Erythrocyte Aggregation / Q000187:drug effects*; D005260:Female; D005780:Gelatin / Q000031:analogs & derivatives / Q000494:pharmacology; D006400:Hematocrit; D006438:Hemodilution; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D010952:Plasma Substitutes / Q000494:pharmacology*; D012709:Serum Albumin / Q000494:pharmacology
D003911:Dextrans; D010952:Plasma Substitutes; D012709:Serum Albumin; D005780:Gelatin; C002803:oxypolygelatine