Production of granulocyte colony-stimulating factor by head and neck carcinomas.
Detectable levels of G-CSF by enzyme-linked immunosorbent assay (ELISA) were found in sera of 4 out of 15 patients with head and neck carcinomas. Also cells prepared from the tumors of these 4 patients secreted G-CSF. The supernatants of cells derived from all 15 patients did not contain granulocyte-monocyte CSF, monocyte CSF, tumor necrosis factor-alpha, transforming growth factor-beta 1, epidermal growth factor, interleukin (IL)-1 beta and IL-6. These findings suggest that leukocytosis in patients with carcinomas might be due to the production of G-CSF by tumor cells.
Tsukuda
M
M
Department of Otorhinolaryngology, Yokohama City University, School of Medicine, Kanagawa, Japan.
Nagahara
T
T
Yago
T
T
Matsuda
H
H
Yanoma
S
S
D002474:Cell-Free System; D016207:Cytokines / Q000096:biosynthesis; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis / Q000096:biosynthesis* / Q000276:immunology; D006258:Head and Neck Neoplasms / Q000378:metabolism*; D006801:Humans; D016188:Receptors, Granulocyte Colony-Stimulating Factor; D014407:Tumor Cells, Cultured
D016207:Cytokines; D016188:Receptors, Granulocyte Colony-Stimulating Factor; D016179:Granulocyte Colony-Stimulating Factor