Lp(a): an acute-phase reactant?
The present study was designed to confirm the transient increases of plasma Lp(a) levels as an acute-phase reactant and to clarify the significance of these increases with the use of patients with acute myocardial infarction and patients subjected to surgical operations. Although interleukin 6, C-reactive protein and alpha 1 antitrypsin reached the maximal levels 1-2 days, 3 days and 4-5 days, respectively, after the episodes, the peak time of Lp(a) levels was delayed some extent in both patient groups. Studying the transient increases of Lp(a) levels as a function of apo(a) isoforms analyzed by density-gradient ultracentrifugation and SDS-PAGE, the higher-density Lp(a) particles preferentially containing high-molecular-weight apo(a) isoforms increased more than the lower-density Lp(a) particles containing low-molecular-weight apo(a) after the episodes. The immunohistochemical findings suggest that Lp(a) may play an important role as an acute-phase reactant in the repair of tissue injury, especially in the process of angiogenesis.
Noma
A
A
Department of Laboratory Medicine, Gifu University School of Medicine, Japan.
Abe
A
A
Maeda
S
S
Seishima
M
M
Makino
K
K
Yano
Y
Y
Shimokawa
K
K
D000210:Acute-Phase Reaction / Q000097:blood*; D001053:Apolipoproteins / Q000378:metabolism; D053241:Apoprotein(a); D002097:C-Reactive Protein / Q000378:metabolism; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D015850:Interleukin-6 / Q000097:blood; D007700:Kinetics; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood; D009389:Neovascularization, Pathologic / Q000378:metabolism; D013514:Surgical Procedures, Operative; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D001053:Apolipoproteins; D015850:Interleukin-6; D017270:Lipoprotein(a); D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein; D053241:Apoprotein(a)