Urinary excretion of thromboxane and markers for renal injury in patients undergoing cardiopulmonary bypass.
Urinary excretion of selected markers for renal injury, as well as urinary excretion rates of the thromboxane metabolite, 11-keto-thromboxane B2 (11k-TXB2), was studied in 36 male patients undergoing coronary bypass surgery using cardiopulmonary bypass (CPB). In all patients, excretion of both tubular (N-acetyl-beta-D-glucosaminidase [beta NAG]; alpha 1-microglobulin [alpha 1-MG]) and glomerular markers (albumin [Alb]; transferrin [Trf]; immunoglobulin G [IgG]) sharply increased on Day 1 after CPB, and they remained elevated throughout the observation period of 5 days. Urinary excretion rates of 11k-TXB2 markedly increased on Day 1 after surgery, and they rapidly decreased thereafter. In 12 of the 36 patients, a temporary increase of serum creatinine levels (> 1.30 mg/dl) was noted following surgery. A positive correlation was found between serum creatinine levels and excretion of the tubular enzyme beta NAG (r = 0.36; p < 0.05), but not between creatinine levels and alpha 1-MG or the glomerular markers. Furthermore, no correlation between urinary excretion of 11k-TXB2 and any of the urinary markers for renal injury could be detected. Our data do not strengthen the hypothesis that acute renal injury observed during CPB is related to exaggerated thromboxane biosynthesis in these patients. Monitoring of urinary markers for incipient renal damage, particularly excretion of beta NAG, might be of additional diagnostic value for detection of otherwise subclinical renal injury in patients undergoing CPB.
Jörres
A
A
Department of Nephrology, Universitätsklinikum Rudolf Virchow, Berlin-Charlottenburg, Germany.
Kordonouri
O
O
Schiessler
A
A
Hess
S
S
Farke
S
S
Gahl
G M
GM
Müller
C
C
Djurup
R
R
D000118:Acetylglucosaminidase / Q000652:urine; D058186:Acute Kidney Injury / Q000175:diagnosis* / Q000209:etiology / Q000652:urine; D000368:Aged; D000419:Albuminuria / Q000652:urine; D000510:Alpha-Globulins / Q000652:urine; D015415:Biomarkers / Q000652:urine; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery; D003404:Creatinine / Q000097:blood; D006801:Humans; D007074:Immunoglobulin G / Q000652:urine; D008297:Male; D008875:Middle Aged; D013929:Thromboxane B2 / Q000031:analogs & derivatives* / Q000652:urine; D014168:Transferrin / Q000652:urine
D000510:Alpha-Globulins; D015415:Biomarkers; D007074:Immunoglobulin G; D014168:Transferrin; C016001:alpha-1-microglobulin; D013929:Thromboxane B2; C049235:11-dehydro-thromboxane B2; D003404:Creatinine; D000118:Acetylglucosaminidase