title: The SOS function-inducing activity of the new nitrothiophenic derivatives in Escherichia coli.
abstract: Genotoxicity and cytotoxic effects of eight new nitrothiophenic compounds with trypanocidal activity were determined by means of the SOS Chromotest assay. Our results indicate that all nitro compounds with one aromatic ring in the R group were genotoxic without and with metabolic activation. The compounds with two aromatic rings in the R group, except for indazol-1-yl, were strongly cytotoxic but they were unable to induce SOS functions without metabolic activation. However, after metabolic activation no cytotoxic effect was observed for these compounds. The role of the nitroreductases to explain the different genotoxic responses of these nitrothiophenic derivatives is discussed.
authors.affiliation: Departamento de Biofísica, Instituto de Biociências-UFRGS, Porto Alegre, RS, Brazil.
authors.forename: K V
authors.initials: KV
authors.lastname: da Silva
authors.forename: B
authors.initials: B
authors.lastname: Mester
authors.forename: J A
authors.initials: JA
authors.lastname: Henriques
mesh_terms: D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D015394:Molecular Structure; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009574:Nitro Compounds / Q000633:toxicity*; D013014:SOS Response, Genetics; D013329:Structure-Activity Relationship; D013876:Thiophenes / Q000633:toxicity*
chemical_list: D009153:Mutagens; D009574:Nitro Compounds; D013876:Thiophenes