title: A new transgenic mouse model of chronic hyperglycemia.
abstract: Expression under the control of the mouse transferrin promoter of a transgene encoding a soluble secreted derivative of the ectodomain of the human insulin receptor in transgenic mice results in the accumulation of this high-affinity insulin-binding protein in the plasma. Alterations of glucose homeostasis are observed including postabsorptive hyperglycemia concomitant with increased hepatic glucose production and hyperinsulinemia. Thus, this is the first transgenic animal model of chronic hyperglycemia with alterations in glucose homeostasis that are produced without a targeted alteration of pancreatic function. These mice provide a new experimental model to follow the progression and long-term consequences of chronic hyperglycemia.
authors.affiliation: W.M. Keck Center for Genome Informatics, Texas A&M University, Houston 77030.
authors.forename: E M
authors.initials: EM
authors.lastname: Schaefer
authors.forename: V
authors.initials: V
authors.lastname: Viard
authors.forename: J
authors.initials: J
authors.lastname: Morin
authors.forename: P
authors.initials: P
authors.lastname: Ferré
authors.forename: L
authors.initials: L
authors.lastname: Pénicaud
authors.forename: P
authors.initials: P
authors.lastname: Ramos
authors.forename: S D
authors.initials: SD
authors.lastname: Maika
authors.forename: L
authors.initials: L
authors.lastname: Ellis
authors.forename: R E
authors.initials: RE
authors.lastname: Hammer
mesh_terms: D000818:Animals; D001667:Binding, Competitive; D001786:Blood Glucose / Q000378:metabolism; D015152:Blotting, Northern; D002908:Chronic Disease; D004195:Disease Models, Animal; D005947:Glucose / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D006943:Hyperglycemia / Q000097:blood / Q000235:genetics / Q000378:metabolism*; D007328:Insulin / Q000097:blood / Q000378:metabolism; D007700:Kinetics; D051379:Mice; D008822:Mice, Transgenic; D011401:Promoter Regions, Genetic; D011485:Protein Binding; D012313:RNA / Q000032:analysis / Q000302:isolation & purification; D011972:Receptor, Insulin / Q000096:biosynthesis* / Q000235:genetics / Q000378:metabolism; D014168:Transferrin / Q000235:genetics
chemical_list: D001786:Blood Glucose; D007328:Insulin; D014168:Transferrin; D012313:RNA; D011972:Receptor, Insulin; D005947:Glucose