title: Radioimmunoscintigraphy with 111indium labeled CYT-356 for the detection of occult prostate cancer recurrence.
abstract: We assessed the safety and ability of the 111indium labeled immunoconjugate 7E11-C5.3-glycyl-tyrosyl-(N,e-diethylenetriaminepentaacetic acid)-lysine (CYT-356) to detect sites of occult prostate cancer in 27 subjects who had undergone radical prostatectomy and whose only evidence of recurrent disease was an increasing (0.8 ng./ml. or greater) serum prostate specific antigen (PSA). All subjects underwent whole body scintigraphy between 2 and 4 days following the radiopharmaceutical injection. Routine blood work and human anti-mouse antibody titers were monitored. Scintigraphic findings were compared with clinical parameters, prostatic fossa biopsy results and conventional imaging techniques. Except for transient hypotension in 1 subject following the second infusion, no side effects or human anti-mouse antibody titers were detected. In 22 subjects 1 or more lesions were detected, of which 11 (50%) were confirmed by biopsy, computerized tomography or magnetic resonance imaging. Of 14 subjects with lesions in the prostatic fossa 13 had biopsies performed, 8 (62%) of which were positive. Magnetic resonance imaging confirmed tumor in the spine and chest computerized tomography findings were compatible with lesions seen in the mediastinum in 1 subject each. There was a statistically significant relationship between detecting a scan abnormality and the initial pathological stage of disease but not with the serum PSA. These data provide preliminary evidence that 111indium labeled CYT-356 can be safely administered and readministered, and it detects sites of occult prostate cancer recurrence in subjects whose PSA is increasing following radical prostatectomy.
authors.affiliation: Department of Radiology, University of Iowa College of Medicine, Iowa City.
authors.forename: D
authors.initials: D
authors.lastname: Kahn
authors.forename: R D
authors.initials: RD
authors.lastname: Williams
authors.forename: D W
authors.initials: DW
authors.lastname: Seldin
authors.forename: J A
authors.initials: JA
authors.lastname: Libertino
authors.forename: M
authors.initials: M
authors.lastname: Hirschhorn
authors.forename: R
authors.initials: R
authors.lastname: Dreicer
authors.forename: G J
authors.initials: GJ
authors.lastname: Weiner
authors.forename: D
authors.initials: D
authors.lastname: Bushnell
authors.forename: J
authors.initials: J
authors.lastname: Gulfo
mesh_terms: D006801:Humans; D007205:Indium Radioisotopes; D008279:Magnetic Resonance Imaging; D008297:Male; D009362:Neoplasm Metastasis / Q000000981:diagnostic imaging; D009364:Neoplasm Recurrence, Local; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging*; D016719:Radioimmunodetection / Q000009:adverse effects
chemical_list: D007205:Indium Radioisotopes; D017430:Prostate-Specific Antigen