Extramammary Paget's disease associated with prostate adenocarcinoma.
A case of scrotal and penile extramammary Paget's disease (EMPD) and concurrent prostate adenocarcinoma in a 59-year-old patient is presented. Immunohistochemically, the tumor cells of both the EMPD and prostate stained positively for prostate-specific antigen. Six previously reported cases of EMPD associated with prostate adenocarcinoma are reviewed, along with a discussion of current theories of the pathogenesis of EMPD.
Sleater
J P
JP
Department of Pathology and Laboratory Medicine, University of Florida College of Medicine, Gainesville 32610.
Ford
M J
MJ
Beers
B B
BB
D000230:Adenocarcinoma / Q000473:pathology*; D002272:Carcinoembryonic Antigen / Q000032:analysis; D005834:Genital Neoplasms, Male / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000473:pathology*; D010145:Paget Disease, Extramammary / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000473:pathology*; D009418:S100 Proteins / Q000032:analysis
D002272:Carcinoembryonic Antigen; D009418:S100 Proteins; D017430:Prostate-Specific Antigen