title: Treatment of linear localized scleroderma with the anti-allergic drug, tranilast.
abstract: A 14-year-old boy with linear localized scleroderma had a dramatic improvement in contractures after treatment with N-(3',4'-dimethoxycinnamoyl) anthranilic acid (tranilast, Rizaben). The observation that this anti-allergic drug was effective in localized scleroderma lends further support to the concept that mast cells play a role in increased collagen synthesis in this disease.
authors.affiliation: Department of Dermatology, Osaka City University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Taniguchi
authors.forename: T
authors.initials: T
authors.lastname: Yorifuji
authors.forename: T
authors.initials: T
authors.lastname: Hamada
mesh_terms: D000293:Adolescent; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007866:Leg; D008297:Male; D009068:Movement; D012594:Scleroderma, Localized / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D014033:Toe Joint / Q000503:physiopathology; D062367:ortho-Aminobenzoates / Q000627:therapeutic use*
chemical_list: D006634:Histamine H1 Antagonists; D062367:ortho-Aminobenzoates; C012293:tranilast