Five new cytotoxic T cell epitopes identified within Epstein-Barr virus nuclear antigen 3.
Epstein-Barr virus (EBV) CD8+ cytotoxic T lymphocyte (CTL) epitopes are currently being considered for inclusion into subunit vaccines. Here we describe the characterization of five new CTL epitopes within EBV nuclear antigen 3 (EBNA3), confirming EBNA3 as a major target for CTL recognition.
Burrows
S R
SR
Queensland Institute of Medical Research, Bancroft Centre, Brisbane, Australia.
Gardner
J
J
Khanna
R
R
Steward
T
T
Moss
D J
DJ
Rodda
S
S
Suhrbier
A
A
D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D016827:CD8 Antigens / Q000276:immunology; D002144:Callithrix; D002461:Cell Line, Transformed; D002467:Cell Nucleus / Q000276:immunology; D004268:DNA-Binding Proteins / Q000276:immunology*; D000939:Epitopes / Q000032:analysis / Q000276:immunology*; D019309:Epstein-Barr Virus Nuclear Antigens; D004854:Herpesvirus 4, Human / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008969:Molecular Sequence Data; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
D000956:Antigens, Viral; D016827:CD8 Antigens; D004268:DNA-Binding Proteins; D000939:Epitopes; D019309:Epstein-Barr Virus Nuclear Antigens; D014614:Vaccines, Synthetic; D014765:Viral Vaccines