[Membranolytic activity of gradex].
The membranolytic activity of gradex towards bacterial protoplasts and human erythrocytes has been demonstrated. Dextran shows no such activity. The lytic activity of gradex towards protoplasts is much lower as compared to gramicidin S. The increase in gramicidin S content from 2 to 5% caused no significant changes in the lytic activity of gradex towards protoplasts. The reduced form of gradex nad no hemolytic effect on human erythrocytes up to a concentration of 300 micrograms/ml. However, the non-reduced form of gradex af a concentration of 500 micrograms/ml lysed from 31 to 48% of erythrocytes depending on the antibiotic content in the polymeric matrix.
Petrykina
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ZM
Polin
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D001410:Bacillus megaterium / Q000648:ultrastructure; D001412:Bacillus subtilis / Q000648:ultrastructure; D003911:Dextrans / Q000494:pharmacology*; D004910:Erythrocyte Membrane / Q000187:drug effects*; D006096:Gramicidin / Q000494:pharmacology* / Q000031:analogs & derivatives; D006461:Hemolysis / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007425:Intracellular Membranes / Q000187:drug effects*
D003911:Dextrans; C066571:gradex; D006096:Gramicidin