Effects of low doses of aprotinin on clotting times activated with celite and kaolin.
The effects of aprotinin (2 x 10(6) and 4 x 10(6) PIU Iniprol) on the activated clotting time (ACT) with both celite- and kaolin-activated tubes were investigated in 52 patients, scheduled for elective coronary artery bypass grafting. Two whole blood samples (2 ml sample volume) were tested simultaneously with Hemochron automated timing systems at different intervals before, during and after cardiopulmonary bypass. At none of the times of measurement there was a difference in ACT measured with celite or with kaolin as coagulation activator. It is concluded that when aprotinin is used in this low dose regimen, celite- and kaolin-activated tubes are equally reliable for monitoring ACT.
Farooqi
N
N
Department of Anesthesia, University Hospital Antwerp, Edegem, Belgium.
De Hert
S
S
Vlaeminck
R
R
De Bakker
A
A
Govaerts
E
E
Vermeyen
K
K
D007611:Aprotinin / Q000494:pharmacology*; D001777:Blood Coagulation / Q000187:drug effects*; D001026:Coronary Artery Bypass; D007692:Diatomaceous Earth / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D007616:Kaolin / Q000494:pharmacology; D008297:Male; D014914:Whole Blood Coagulation Time
D007616:Kaolin; D007692:Diatomaceous Earth; D007611:Aprotinin