[The value of Sm-153-EDTMP for treatment of metastatic bone pain and improving quality of life].
Sm-153-EDTMP (ethylenediaminetetramethylene phosphonic acid), a beta-particle and gamma-emitting radionuclide, was used for pain control of bone metastasis. Fourty patients with bone metastasis were administrated a single intravenous injection of 29.6 MBq/kg (0.8mCi/kg), and 7 of them received more than one injection. No obvious side effect was observed. The skeletal images obtained with Sm-153-EDTMP were similar to that of Tc-99m-MDP SPECT images. Follow up study (at least 30 days) revealed bone pain relief and improved quality of life in 82.5% of the treated patients.
Jiang
C Y
CY
Cancer Hospital of Shanghai Medical University.
Zhu
B L
BL
Zhang
Y J
YJ
D000328:Adult; D000368:Aged; D001859:Bone Neoplasms / Q000532:radiotherapy* / Q000556:secondary*; D001943:Breast Neoplasms / Q000473:pathology; D002614:Chelating Agents / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010148:Intractable Pain / Q000532:radiotherapy*; D010166:Palliative Care; D011788:Quality of Life; D011868:Radioisotopes / Q000627:therapeutic use*; D012493:Samarium / Q000627:therapeutic use*
D002614:Chelating Agents; D009943:Organophosphorus Compounds; D011868:Radioisotopes; C018940:(ethylenedinitrilo)-tetramethylenephosphonic acid; D012493:Samarium