Therapy other than reverse transcriptase inhibitors for HIV infection.
Antiretroviral drugs against HIV infection have been developed that inhibit various stages of the HIV replication cycle. Agents other than reverse transcriptase inhibitors are reviewed with particular attention to those under study in clinical trials, including inhibitors of the virus-encoded protease enzyme. In addition, innovative strategies using gene therapy are described. It is concluded that combinations of agents may be the best approach for minimizing toxicity and reducing or delaying the emergence of drug-resistant virus during therapy.
Kaplan
J C
JC
Infectious Disease Unit, Massachusetts General Hospital, Boston.
Hirsch
M S
MS
D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000628:therapy*; D000998:Antiviral Agents / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D015316:Genetic Therapy; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D006801:Humans; D018894:Reverse Transcriptase Inhibitors; D014779:Virus Replication
D000998:Antiviral Agents; D004279:DNA, Viral; D018894:Reverse Transcriptase Inhibitors