title: Epinephrine-induced ventricular premature complexes due to early afterdepolarizations and effects of verapamil and propranolol in a patient with congenital long QT syndrome.
abstract: We report a patient with congenital long QT syndrome in whom early afterdepolarizations (EADs) were demonstrated on monophasic action potential (MAP) recordings in the left ventricular mid-base inferior wall. Epinephrine infusion at 5 micrograms/min increased the amplitude of the EADs and the late component of the T(U) wave. Epinephrine also induced ventricular premature complexes (VPCs) with right bundle branch block morphology and left-axis deviation that occurred from the peak of the EADs. Verapamil injection (5 mg) during continuous epinephrine infusion abolished all VPCs with a slight reduction in the amplitude of the EADs. Propranolol injection (5 mg) in addition to verapamil further reduced the amplitude of the EADs and the late component of the T(U) wave. These findings suggest that the epinephrine-induced VPCs were closely related to triggered rhythm arising from the EADs, and that both verapamil and propranolol were effective for the suppression of VPCs and EADs.
authors.affiliation: Department of Internal Medicine, National Cardiovascular Center, Osaka, Japan.
authors.forename: W
authors.initials: W
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Ohe
authors.forename: T
authors.initials: T
authors.lastname: Kurita
authors.forename: T
authors.initials: T
authors.lastname: Tokuda
authors.forename: K
authors.initials: K
authors.lastname: Shimomura
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000328:Adult; D005117:Cardiac Complexes, Premature / Q000503:physiopathology*; D004837:Epinephrine; D005260:Female; D006801:Humans; D008133:Long QT Syndrome / Q000151:congenital / Q000188:drug therapy* / Q000503:physiopathology*; D011433:Propranolol / Q000627:therapeutic use*; D014700:Verapamil / Q000627:therapeutic use*
chemical_list: D011433:Propranolol; D014700:Verapamil; D004837:Epinephrine