title: Mutation induction by accelerated heavy ions in bacteria.
abstract: Induction of lacI- forward mutations in Escherichia coli Ymcl and his(-)-->his+ reversions in Salmonella typhimurium TA102 was investigated after irradiation with heavy ions in the range of Z = 1-36. Particle specific energies (E) were in the range of 1-600 MeV/u. A strong dependence of the mutation induction cross-section (sigma m) on both particle energy and LETinfinity was observed. The results suggest that two different ranges of LETinfinity can be distinguished. In the range of high LETinfinity (> 100 keV/micron) sigma m increases with increasing specific particle energy if LETinfinity is kept constant (Fe ions as compared with carbon ions or alpha-particles). In the range of low LETinfinity (< 100 keV/micron) sigma m decreases with increasing energy (Ne ions as compared with He ions).
authors.affiliation: Institute of Biophysics, Academy of Sciences of the Czech Republic, Brno.
authors.forename: S
authors.initials: S
authors.lastname: Kozubek
authors.forename: L
authors.initials: L
authors.lastname: Rýznar
authors.forename: G
authors.initials: G
authors.lastname: Horneck
mesh_terms: D003903:Deuterium; D004735:Energy Transfer; D004926:Escherichia coli / Q000235:genetics / Q000528:radiation effects*; D005720:Gamma Rays; D005798:Genes, Bacterial / Q000528:radiation effects; D006371:Helium; D007477:Ions; D007501:Iron; D016296:Mutagenesis; D009356:Neon; D010315:Particle Accelerators; D012486:Salmonella typhimurium / Q000235:genetics / Q000528:radiation effects*
chemical_list: D007477:Ions; D006371:Helium; D009356:Neon; D003903:Deuterium; D007501:Iron