title: Impaired G-CSF production at post-transcriptional level in a patient with chronic idiopathic neutropenia.
abstract: Chronic idiopathic neutropenia (CIN) is a disorder characterized by severe neutropenia and a maturational arrest of the neutrophil precursors in the bone marrow. The pathogenesis of this disorder has been obscure. We examined the production of endogenous G-CSF and the expression of G-CSFmRNA in a patient with adult type CIN. The G-CSF production by the patient's mononuclear cells was deficient in spite of the adequate accumulation of G-CSFmRNA. Our data suggests that the defect in the endogenous G-CSF production at the post-transcriptional level is likely to be an aetiological factor in CIN.
authors.affiliation: Department of Internal Medicine, Shimane Medical University.
authors.forename: K
authors.initials: K
authors.lastname: Morikawa
authors.forename: S
authors.initials: S
authors.lastname: Yamamori
authors.forename: K
authors.initials: K
authors.lastname: Oiwa
authors.forename: S
authors.initials: S
authors.lastname: Morikawa
authors.forename: F
authors.initials: F
authors.lastname: Oseko
authors.forename: T
authors.initials: T
authors.lastname: Kubota
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D002478:Cells, Cultured; D002908:Chronic Disease; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008297:Male; D009000:Monocytes / Q000378:metabolism; D009503:Neutropenia / Q000097:blood* / Q000209:etiology / Q000235:genetics; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D014158:Transcription, Genetic
chemical_list: D012333:RNA, Messenger; D016179:Granulocyte Colony-Stimulating Factor