The clinical relevance of L26, a B-cell-specific antibody, in Hodgkin's disease.
Although Reed-Sternberg cells and their variants (RS/V) in most cases of Hodgkin's disease (HD) lack lymphocyte-associated antigens, some cases of HD, particularly nodular lymphocyte-predominant HD (NLPHD), contain RS/V cells that appear to be of B-cell origin. This study was designed to test whether differences in clinical presentation and therapeutic response exist between patients with HD of various histologic types whose tumors contain RS/V cells that express antigens recognized by L26, an antibody directed against B lymphocytes, and those that do not. We studied 46 patients with stages I and II HD who were treated with radiotherapy alone between 1969 and 1986. Although the expression of L26 and the other antibodies was not predictive for relapse-free, cause-specific, or absolute survival, the labeling of the RS/V cells with L26, independent of histologic type, was significantly associated with peripheral lymph nodal presentation, male gender, and infradiaphragmatic presentation.
Molot
R J
RJ
Department of Pathology, University of Florida College of Medicine, Gainesville.
Mendenhall
N P
NP
Barré
D M
DM
Braylan
R C
RC
D015703:Antigens, CD / Q000032:analysis*; D018951:Antigens, CD20; D000944:Antigens, Differentiation, B-Lymphocyte / Q000032:analysis*; D000951:Antigens, Neoplasm / Q000032:analysis*; D005260:Female; D006689:Hodgkin Disease / Q000276:immunology / Q000401:mortality / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D016130:Immunophenotyping; D008297:Male; D009367:Neoplasm Staging; D016539:Reed-Sternberg Cells / Q000276:immunology*; D016019:Survival Analysis
D015703:Antigens, CD; D018951:Antigens, CD20; D000944:Antigens, Differentiation, B-Lymphocyte; D000951:Antigens, Neoplasm