[Histological assessment of the liver long after interferon treatment in patients with chronic type C hepatitis].
The effects of interferon on chronic hepatitis C long after the treatments were assessed biochemically, virologically and histologically. Among the 12 cases who showed normal alanine aminotransferase (ALT) levels and seroconversion of HCV RNA after treatment, histological improvements were observed in 8. In contrast, among the 11 cases who showed abnormal ALT levels and HCV viremia after treatment, histological improvements were observed in only 1. Histological improvement of the liver was thus, well correlated with normalization of ALT levels and seroconversion of HCV RNA. These data indicate that complete histological resolution of chronic hepatitis C is obtainable by elimination of the virus by interferon treatment.
Yokosuka
O
O
First Department of Medicine, Chiba University School of Medicine.
Hosoda
K
K
Omata
M
M
D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000473:pathology* / Q000628:therapy*; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D008099:Liver / Q000473:pathology*; D012367:RNA, Viral / Q000097:blood
D015415:Biomarkers; D012367:RNA, Viral; D007372:Interferons