The human gene for water channel aquaporin 1 (AQP1) is localized on chromosome 7p15-->p14.
The chromosomal localization of the gene encoding aquaporin 1 (previously called CHIP28), which acts as a water channel in erythrocytes and in the renal proximal tubules and descending limbs of Henle, was determined. Southern blot hybridizations on chromosomal DNA of a panel of 25 different human x rodent hybrid cell lines localized the aquaporin 1 gene to human chromosome 7. Additionally, in situ hybridization on R-banded metaphase chromosomes sublocalized the aquaporin 1 gene (AQP1) to 7p15-->p14, and some sequence-tagged sites in this region were identified.
Deen
P M
PM
Department of Physiology, University of Nijmegen, The Netherlands.
Weghuis
D O
DO
Geurs van Kessel
A
A
Wieringa
B
B
van Os
C H
CH
D000818:Animals; D051398:Aquaporin 1; D020346:Aquaporins; D001483:Base Sequence; D001789:Blood Group Antigens; D002874:Chromosome Mapping; D002897:Chromosomes, Human, Pair 7; D004247:DNA; D006801:Humans; D006822:Hybrid Cells; D007473:Ion Channels / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D051381:Rats
C496020:AQP1 protein, human; C496022:Aqp1 protein, rat; D020346:Aquaporins; D001789:Blood Group Antigens; D007473:Ion Channels; D008565:Membrane Proteins; D051398:Aquaporin 1; D004247:DNA