Chromosomal anomalies in atypical adenomatous hyperplasia and carcinoma of the prostate using fluorescence in situ hybridization.
OBJECTIVE
The genetic alterations of atypical adenomatous hyperplasia (AAH) of the prostate, a possible precursor of prostate adenocarcinoma, have not been previously investigated.


METHODS
We used fluorescence in situ hybridization with centromere-specific probes for chromosomes 7, 8, 10, 12, and Y to evaluate chromosomal anomalies in atypical adenomatous hyperplasia (23 foci) and adenocarcinoma (31 foci) in 19 whole-mount radical prostatectomy specimens.


RESULTS
Chromosomal anomalies were found in 2 foci (9%) of AAH and 17 foci (55%) of carcinoma. There was no relationship between the chromosomal anomalies in AAH and matched foci of carcinoma.


CONCLUSIONS
These findings indicate that AAH is not obviously linked genetically to prostate cancer, although it occasionally contains chromosomal anomalies.
Qian
J
J
Department of Laboratory Medicine, Mayo Clinic, Rochester, MN 55905, USA.
Jenkins
R B
RB
Bostwick
D G
DG
D000230:Adenocarcinoma / Q000235:genetics*; D000368:Aged; D002869:Chromosome Aberrations; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000235:genetics*; D011471:Prostatic Neoplasms / Q000235:genetics*