title: [The circadian rhythm of fluctuations in the gonadoliberin level in the rat hypothalamus and the effect on it of different xenobiotics].
abstract: An obvious circadian rhythm of the gonadoliberine levels was found in the Organum vasculosum of Lamina terminalis: the level being very low in the morning, rising 5-fold after midday and 10-fold at 5-6 p.m. The rhythm did not depend on the oestrous cycle stage and was not found in males. Xenobiotics interfere with the rhythm due, probably, to lowering of the suppressive tonus.
authors.forename: M G
authors.initials: MG
authors.lastname: Stepanov
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002940:Circadian Rhythm / Q000187:drug effects* / Q000502:physiology; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis / Q000187:drug effects* / Q000502:physiology; D007031:Hypothalamus / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D013997:Time Factors; D015262:Xenobiotics / Q000494:pharmacology*
chemical_list: D015262:Xenobiotics; D007987:Gonadotropin-Releasing Hormone