Prostacyclin contributes to nitroglycerin-mediated relaxation of human umbilical arteries.
This study compared the action of nitroglycerin (GTN) and linsidomine (SIN-1) on vessel tone and prostacyclin (PGI2) production of human umbilical arteries in vitro. GTN-induced vessel relaxation was significantly attenuated by indomethacin pretreatment. This was associated with a significant inhibition of the fourfold stimulation of PGI2 release by GTN. No such effects were seen with SIN-1. We concluded that GTN-induced PGI2 release contributed to the vasodilatory action of organic nitrates in the fetoplacental circulation.
Klockenbusch
W
W
Institut für Pharmakologie, Heinrich-Heine-Universität Düsseldorf, Germany.
Schrör
K
K
D011464:Epoprostenol / Q000378:metabolism*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007213:Indomethacin / Q000494:pharmacology; D008981:Molsidomine / Q000031:analogs & derivatives / Q000494:pharmacology; D009126:Muscle Relaxation / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects*; D005996:Nitroglycerin / Q000494:pharmacology*; D011247:Pregnancy; D014469:Umbilical Arteries / Q000187:drug effects* / Q000378:metabolism; D014664:Vasodilation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology
D014665:Vasodilator Agents; C002385:linsidomine; D008981:Molsidomine; D011464:Epoprostenol; D005996:Nitroglycerin; D007213:Indomethacin