Nitric oxide synthase inhibitors 7- and 6-nitroindazole relax smooth muscle in vitro.
7-Nitroindazole induced concentration-dependent relaxation of precontracted rabbit aorta, dog middle cerebral artery, rat anococcygeus muscle and rat stomach fundus. Relaxations to 7-nitroindazole in rabbit aorta were unaffected by nitric oxide synthase blockade or endothelial removal. 6-Nitroindazole also caused concentration-dependent relaxation in dog middle cerebral artery and rabbit aorta, being equipotent with 7-nitroindazole in both tissues. These data suggest that indazole derivatives can induce an endothelium- and nitric oxide synthase-independent relaxation of smooth muscle in vitro.
Medhurst
A D
AD
Department of Neurology, SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK.
Greenlees
C
C
Parsons
A A
AA
Smith
S J
SJ
D000525:Alprazolam / Q000494:pharmacology; D000818:Animals; D001381:Azepines / Q000494:pharmacology; D003092:Colitis / Q000139:chemically induced / Q000503:physiopathology; D003106:Colon / Q000187:drug effects / Q000378:metabolism*; D005769:Gastrointestinal Motility / Q000187:drug effects*; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D009479:Neuropeptides / Q000378:metabolism* / Q000502:physiology; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013373:Substance P / Q000378:metabolism / Q000502:physiology; D014230:Triazoles / Q000494:pharmacology; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism / Q000502:physiology
D001381:Azepines; D007457:Iodine Radioisotopes; D009479:Neuropeptides; D010972:Platelet Activating Factor; D014230:Triazoles; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; C063964:bepafant; D000525:Alprazolam