Comparative effects of the dihydropyridine-type calcium-agonists (-)-S-Bay K 8644, (+/-)-Bay-W 5035 and (+/-)-Bay-T 5006 on human platelet aggregability.
1. Human platelet aggregation induced by collagen is concentration-dependently inhibited by dihydropyridine (DHP)-type calcium(Ca)-agonists. 2. There was no significant difference between the maximal anti-aggregatory effects or the anti-aggregatory potencies of (-)-S-Bay-K 8644 (EC50: 5.3 +/- 1.5 x 10(-5) M), (+/-)-Bay-W 5035 (EC50: 14.9 +/- 8.8 x 10(-5) M) or (+/-)-Bay-T 5006 (EC50: 2.7 +/- 1.9 x 10(-5) M) (P > 0.05). 3. Antiaggregatory effects of DHP-type Ca-agonists seem to be independent of Ca-channel activation.
Rump
A F
AF
Institut für Pharmakologie, Universität Köln, Germany.
Boller
M
M
Berkels
R
R
Rösen
R
R
Fricke
U
U
Klaus
W
W
D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology; D000328:Adult; D002120:Calcium Channel Agonists / Q000494:pharmacology*; D002319:Cardiovascular System / Q000187:drug effects; D004095:Dihydropyridines / Q000494:pharmacology; D006801:Humans; D015394:Molecular Structure; D009539:Nicotinic Acids / Q000494:pharmacology; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011724:Pyridazines / Q000494:pharmacology; D013329:Structure-Activity Relationship
D002120:Calcium Channel Agonists; D004095:Dihydropyridines; D009539:Nicotinic Acids; D010975:Platelet Aggregation Inhibitors; D011724:Pyridazines; C082958:Bay W 5035; C082957:Bay T 5006; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester