The insulin-like growth factor I receptor gene is the target for the 15q26 amplicon in breast cancer.
We report the amplification and overexpression of the IGFIR (insulin-like growth factor I receptor) gene in primary breast cancers with an amplification of band 15q26. The involvement of IGFIR, which may vary in frequency from 2-3% in unselected tumor series to more than 10% in breast cancers with hsr, may represent an important event in tumor progression.
Almeida
A
A
CNRS URA 620, Institut Curie, Section de Biologie, Paris, France.
Muleris
M
M
Dutrillaux
B
B
Malfoy
B
B
D015152:Blotting, Northern; D015139:Blotting, Southern; D001943:Breast Neoplasms / Q000235:genetics*; D002265:Carboxylic Ester Hydrolases / Q000096:biosynthesis / Q000235:genetics; D002884:Chromosomes, Human, Pair 15; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics*; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins; D051578:Proto-Oncogene Proteins c-fes; D012334:RNA, Neoplasm / Q000235:genetics; D017526:Receptor, IGF Type 1 / Q000096:biosynthesis / Q000235:genetics*
D004273:DNA, Neoplasm; D009363:Neoplasm Proteins; D011518:Proto-Oncogene Proteins; D012334:RNA, Neoplasm; D011505:Protein-Tyrosine Kinases; D017526:Receptor, IGF Type 1; C496645:FES protein, human; D051578:Proto-Oncogene Proteins c-fes; D002265:Carboxylic Ester Hydrolases