title: Transbronchial biopsy in patients with pulmonary eosinophilic granuloma. Comparison with findings on open lung biopsy.
abstract: We evaluated the findings on transbronchial biopsy specimens in reference to open lung biopsy specimens from 12 patients with pulmonary eosinophilic granuloma. Features in transbronchial biopsy specimens were further contrasted to those of patients with interstitial fibrosis and nondiagnostic biopsy specimens for localized lesions. Transbronchial biopsy specimens were randomized and graded for histologic features and cellularity. Patients with eosinophilic granuloma had more macrophages (P < .05) but equivalent numbers of eosinophils, neutrophils, and Langerhans' cells compared with those of the other two groups. Only two endoscopic biopsy specimens were histologically diagnostic or highly consistent with eosinophilic granuloma. We conclude that the diagnosis of eosinophilic granuloma is possible on transbronchial biopsy but requires a high index of suspicion. The demonstration of Langerhans' cells by immunohistochemical staining for S100 protein is a useful adjunct. The low diagnostic yield for eosinophilic granuloma on transbronchial biopsy results from inadequate sampling and from the nonspecific appearance of discrete lesions in small tissue samples.
authors.affiliation: Department of Pathology, Case Western Reserve University School of Medicine, MetroHealth Medical Center, Cleveland, Ohio 44109.
authors.forename: I
authors.initials: I
authors.lastname: Housini
authors.forename: J F
authors.initials: JF
authors.lastname: Tomashefski
authors.forename: A
authors.initials: A
authors.lastname: Cohen
authors.forename: J
authors.initials: J
authors.lastname: Crass
authors.forename: J
authors.initials: J
authors.lastname: Kleinerman
mesh_terms: D000328:Adult; D001706:Biopsy / Q000379:methods*; D001980:Bronchi; D004803:Eosinophilic Granuloma / Q000276:immunology / Q000473:pathology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D008168:Lung / Q000276:immunology / Q000473:pathology*; D008171:Lung Diseases / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000473:pathology; D012189:Retrospective Studies; D009418:S100 Proteins / Q000032:analysis; D013194:Staining and Labeling
chemical_list: D009418:S100 Proteins