title: [Multiple endocrine neoplasia type 1. Digestive hormones in the screening].
abstract: Detection of subjects from a multiple endocrine neoplasia type 1 family must rest on clinical, biochemical and radiological data, since study of the genome is unable to detect these subjects. In the new family described here, 6 out of the 14 subjects explored were affected. One had a confirmed pancreatic endocrine tumour and in 3 others a pancreatic endocrine tumour was highly probable, since insulin and glucagon levels, as well as ultrasonic exploration of the pancreas were pathological. Measurements of gastrointestinal hormones gave normal results in all cases. We conclude that to detect this endocrine neoplasia in subjects at risk it seems necessary to measure plasma insulin levels and perform an abdominal ultrasonography.
authors.affiliation: Service d'Endocrinologie, Diabétologie et Nutrition, Hôpital Edouard Herriot, Lyon.
authors.forename: A
authors.initials: A
authors.lastname: Carreau
authors.forename: C
authors.initials: C
authors.lastname: Badet
authors.forename: M
authors.initials: M
authors.lastname: Laville
authors.forename: R
authors.initials: R
authors.lastname: Mornex
authors.forename: J A
authors.initials: JA
authors.lastname: Chayvialle
authors.forename: H
authors.initials: H
authors.lastname: Rousset
authors.forename: J P
authors.initials: JP
authors.lastname: Riou
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001786:Blood Glucose / Q000032:analysis; D002096:C-Peptide / Q000032:analysis; D002648:Child; D005260:Female; D005755:Gastrins / Q000032:analysis*; D005934:Glucagon / Q000032:analysis; D006801:Humans; D007328:Insulin / Q000097:blood; D008297:Male; D008875:Middle Aged; D009377:Multiple Endocrine Neoplasia / Q000097:blood / Q000235:genetics / Q000517:prevention & control*; D010190:Pancreatic Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000235:genetics / Q000517:prevention & control*; D010191:Pancreatic Polypeptide / Q000032:analysis*; D010911:Pituitary Neoplasms / Q000097:blood / Q000235:genetics / Q000517:prevention & control*; D012307:Risk Factors; D013373:Substance P / Q000032:analysis; D014463:Ultrasonography; D014660:Vasoactive Intestinal Peptide / Q000032:analysis
chemical_list: D001786:Blood Glucose; D002096:C-Peptide; D005755:Gastrins; D007328:Insulin; D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D010191:Pancreatic Polypeptide; D005934:Glucagon