title: Localization of striatal and nigral tachykinin receptors in the rat.
abstract: The effects of lesioning mesostriatal dopamine projections or striatal neurons on tachykinin binding in the basal ganglia were assessed in the rat. 6-Hydroxydopamine lesions of the medial forebrain bundle destroyed striatal dopamine terminals as assessed by [3H]mazindol autoradiography, but did not significantly affect the binding of NK-1 ([3H][Sar9,Met(O2)11]substance P) or NK-3 ([3H]senktide) tachykinin ligands in the striatum. 6-Hydroxydopamine lesions significantly reduced NK-3 binding in the substantia nigra pars compacta, but not the ventral tegmental area. In contrast, striatal quinolinic acid lesions reduced both NK-1 and NK-3 binding in the striatum, but failed to affect NK-3 binding in the substantia nigra. These findings suggest that both NK-1 and NK-3 receptors within the striatum are predominantly post-synaptic with respect to dopamine neurons, whereas nigral NK-3 receptors are located on dopaminergic neurons.
authors.affiliation: Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
authors.forename: A J
authors.initials: AJ
authors.lastname: Stoessl
mesh_terms: D000818:Animals; D001345:Autoradiography; D003342:Corpus Striatum / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D008454:Mazindol / Q000378:metabolism; D008474:Medial Forebrain Bundle / Q000187:drug effects; D016627:Oxidopamine / Q000494:pharmacology; D010446:Peptide Fragments / Q000378:metabolism; D017378:Quinolinic Acid / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018039:Receptors, Tachykinin / Q000378:metabolism*; D013373:Substance P / Q000031:analogs & derivatives / Q000378:metabolism; D013378:Substantia Nigra / Q000378:metabolism*; D014018:Tissue Distribution
chemical_list: D010446:Peptide Fragments; D018039:Receptors, Tachykinin; C054724:senktide; D013373:Substance P; D016627:Oxidopamine; D008454:Mazindol; D017378:Quinolinic Acid