Anti-emetic profile of a non-peptide neurokinin NK1 receptor antagonist, CP-99,994, in ferrets.
In the ferret, 5-HT3 receptor antagonists are effective in controlling emesis produced by cytotoxic agents or radiation. To investigate the possibility that substance P has a role, as well as 5-HT, in the emetic reflex pathway, we have examined the anti-emetic effects of a NK1 receptor antagonist (racemic CP-99,994) in the ferret. Racemic CP-99,994 was effective against a range of emetogens, comprising cytotoxic drugs, radiation, morphine, ipecacuanha and copper sulphate.
Bountra
C
C
Department of Gastrointestinal Pharmacology, Glaxo Group Research Ltd., Greenford, Middx, UK.
Bunce
K
K
Dale
T
T
Gardner
C
C
Jordan
C
C
Twissell
D
D
Ward
P
P
D000818:Animals; D005289:Ferrets; D008297:Male; D015288:Neurokinin A / Q000037:antagonists & inhibitors*; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use*; D013237:Stereoisomerism; D013373:Substance P / Q000378:metabolism*; D014839:Vomiting / Q000139:chemically induced / Q000188:drug therapy*
D010880:Piperidines; C080755:3-(2-methoxybenzylamino)-2-phenylpiperidine; D013373:Substance P; D015288:Neurokinin A