Multiple effects of interferon on the replication of human immunodeficiency virus type 1.
In this review, I shall summarize the major findings about the effect of IFN on the replication of HIV-1 virus in model systems in vitro and will describe the known molecular mechanisms involved in the IFN-mediated inhibition of HIV-1 replication. Finally, I shall relate these findings to the unique features of the HIV-1 replication cycle.
Pitha
P M
PM
Oncology Center, Johns Hopkins University, Baltimore, MD 21231.
D015497:HIV-1 / Q000187:drug effects* / Q000254:growth & development; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D016086:Lentivirus / Q000187:drug effects; D008264:Macrophages / Q000382:microbiology; D011533:Proviruses; D013601:T-Lymphocytes / Q000382:microbiology; D014158:Transcription, Genetic; D014779:Virus Replication / Q000187:drug effects
D007372:Interferons