Stratification of the channel domain in neurotransmitter receptors.
Analyses of the ionic pore of ligand-gated ion channels at the amino acid level reveal a structural and functional stratification of the M2 channel domain. Mutations in the equatorial and outer regions affect channel gating, whereas mutations of other amino acid rings alter ionic permeability or selectivity.
Bertrand
D
D
Department of Physiology, Centre Medical Universitaire, Geneva, Switzerland.
Galzi
J L
JL
Devillers-Thiéry
A
A
Bertrand
S
S
Changeux
J P
JP
D000818:Animals; D001665:Binding Sites; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000037:antagonists & inhibitors / Q000737:chemistry*; D017434:Protein Structure, Tertiary; D017981:Receptors, Neurotransmitter / Q000737:chemistry*
D007473:Ion Channels; D017981:Receptors, Neurotransmitter