title: Non-metastatic childhood ependymomas.
abstract: OBJECTIVE
  Intracranial ependymomas of childhood are relatively infrequent. There are significant disagreements concerning optimal postoperative treatment as well as the patterns of relapse following treatment. The purpose of this retrospective study was the analysis of the recurrence pattern and therefore the implication on the extent of the radiotherapy fields. Data from 37 patients referred within 19 years were used for this study.
  
  
  METHODS
  From April 1975 to July 1993, 37 children aged 1-14 years were referred for postoperative treatment of an intracranial ependymoma. Twenty-eight children received postoperative radiation therapy and 26 patients received chemotherapy. The median follow-up is 6 years (range 2 months to 19 years).
  
  
  RESULTS
  Overall survival and event free survival at 5 and 10 years were 40%. Eighteen children relapsed. Relapses occurred from 1.5 months to 3.6 years post treatment. Relapses were distant in four cases and local in 14. Age, sex, extent of primary resection, chemotherapy and type of radiation therapy did not influence the outcome. Children with poorly differentiated tumors who did not receive postoperative radiation therapy had a higher relapse rate but this difference is not statistically significant.
  
  
  CONCLUSIONS
  Despite doses of radiation > or = 50 Gy the majority of recurrences were local. Our results, despite the small number of patients are in accordance to those previously published, suggest that prophylactic craniospinal irradiation is superfluous. Better means of achieved local control are required, such as three-dimensional conformal radiation therapy with dose-escalation study or hyperfractionation regimen.
authors.affiliation: Department of Radiotherapy-Oncology, Centre Léon Bérard, Lyon, France.
authors.forename: C
authors.initials: C
authors.lastname: Carrie
authors.forename: C
authors.initials: C
authors.lastname: Mottolese
authors.forename: E
authors.initials: E
authors.lastname: Bouffet
authors.forename: S
authors.initials: S
authors.lastname: Negrier
authors.forename: T H
authors.initials: TH
authors.lastname: Bachelot
authors.forename: C
authors.initials: C
authors.lastname: Lasset
authors.forename: S
authors.initials: S
authors.lastname: Helfre
authors.forename: J
authors.initials: J
authors.lastname: Guyotat
authors.forename: C L
authors.initials: CL
authors.lastname: Lapras
authors.forename: M
authors.initials: M
authors.lastname: Brunat-Mentigny
mesh_terms: D000293:Adolescent; D001932:Brain Neoplasms / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004806:Ependymoma / Q000401:mortality / Q000532:radiotherapy / Q000628:therapy*; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D012008:Recurrence; D012189:Retrospective Studies; D015996:Survival Rate