Cystic fibrosis gene therapy using an adenovirus vector: in vivo safety and efficacy in nasal epithelium.
Welsh
M J
MJ
Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242.
Smith
A E
AE
Zabner
J
J
Rich
D P
DP
Graham
S M
SM
Gregory
R J
RJ
Pratt
B M
BM
Moscicki
R A
RA
D000260:Adenoviruses, Human / Q000502:physiology; D000281:Administration, Intranasal; D002985:Clinical Protocols; D003264:Containment of Biohazards; D003550:Cystic Fibrosis / Q000235:genetics / Q000628:therapy*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D003673:Defective Viruses / Q000502:physiology; D004848:Epithelium; D005069:Evaluation Studies as Topic; D015316:Genetic Therapy / Q000009:adverse effects / Q000379:methods; D005822:Genetic Vectors; D006801:Humans; D008565:Membrane Proteins / Q000235:genetics; D009297:Nasal Mucosa; D012306:Risk; D012449:Safety; D014779:Virus Replication
C505032:CFTR protein, human; D008565:Membrane Proteins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator