A tumor cell line producing granulocyte colony-stimulating factor and an immune suppressive factor.
From a patient, both a cell line incapable of secreting granulocyte colony-stimulating factor (G-CSF) (TC873) and a cell line capable of secreting G-CSF (TCM902) were established. The effector cells induced, with TC873 cells showed a high lytic capacity against two types of tumor cells. The effector cells induced by TCM902 cells did not show such capacity. Furthermore, the TCM902 cells excreted a factor suppressing the proliferation of lymphokine activated killer (LAK) cells and the autologous tumor cell lysis of tumor associated lymphocytes. This factor probably is TFG-beta 1.
Tsukuda
M
M
Department of Otorhinolaryngology, Yokohama City University, School of Medicine, Kanagawa, Japan.
Nagahara
T
T
Mikami
Y
Y
Yago
T
T
Matsuda
H
H
Yanoma
S
S
D002474:Cell-Free System / Q000276:immunology; D016207:Cytokines / Q000378:metabolism; D003602:Cytotoxicity, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D007166:Immunosuppressive Agents / Q000378:metabolism*; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D007963:Leukocytes, Mononuclear / Q000276:immunology; D007959:Lymphocyte Culture Test, Mixed; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D016188:Receptors, Granulocyte Colony-Stimulating Factor; D014407:Tumor Cells, Cultured
D016207:Cytokines; D007166:Immunosuppressive Agents; D016188:Receptors, Granulocyte Colony-Stimulating Factor; D016179:Granulocyte Colony-Stimulating Factor