Modern concepts of immunotherapy.
Although common allergies have been considered as immediate IgE antibody mediated responses, attention is now turning to inflammatory responses that appear to be initiated by T-cell responses to peptides from allergens presented in combination with HLA class II molecules. Although classic immunotherapy with allergen extracts has been found to downregulate these T-cell responses, more efficient and safe methods are being sought.
Norman
P S
PS
Johns Hopkins Asthma and Allergy Center, Baltimore, Maryland 21224.
D000818:Animals; D003888:Desensitization, Immunologic; D015536:Down-Regulation; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D013601:T-Lymphocytes / Q000276:immunology
D000939:Epitopes