title: Induction of chromosome aberrations by pyrimethamine in cultured Chinese hamster (CHL) cells.
abstract: Induction of chromosome aberrations was investigated in cultured Chinese hamster cells treated with pyrimethamine. Pyrimethamine without metabolic activation strongly induced structural chromosome aberrations in a dose-dependent manner. Aberrant metaphase cells occurred at a frequency of 80%, when cells were treated at 1.6 microgram/ml for 48 h.
authors.affiliation: National Veterinary Assay Laboratory, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: M
authors.initials: M
authors.lastname: Norimatsu
authors.forename: H
authors.initials: H
authors.lastname: Yoshimura
mesh_terms: D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D008168:Lung / Q000166:cytology; D008938:Mitosis / Q000187:drug effects; D009153:Mutagens / Q000633:toxicity*; D011739:Pyrimethamine / Q000633:toxicity*
chemical_list: D009153:Mutagens; D011739:Pyrimethamine