Antioxidative and antimutagenic effects of theaflavins from black tea.
Theaflavins, polyphenolic ingredients of black tea, were observed to inhibit in vitro lipid peroxidation in the erythrocyte membrane ghost and microsomal systems. Theaflavins also showed inhibition of DNA single-strand cleavage and mutagenicity, both induced by hydrogen peroxide. These results suggest that theaflavins scavenge radicals to produce antioxidative and antimutagenic effects. It was also found that the gallic acid moiety of theaflavins is essential for their potent antioxidative activities.
Shiraki
M
M
Food Research Laboratories, Mitsui Norin Co., Ltd., Shizuoka, Japan.
Hara
Y
Y
Osawa
T
T
Kumon
H
H
Nakayama
T
T
Kawakishi
S
S
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D000975:Antioxidants / Q000494:pharmacology*; D044946:Biflavonoids; D001711:Biotransformation; D002392:Catechin; D004277:DNA, Single-Stranded / Q000187:drug effects; D004910:Erythrocyte Membrane / Q000187:drug effects; D006861:Hydrogen Peroxide / Q000633:toxicity; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects; D008862:Microsomes, Liver / Q000187:drug effects / Q000378:metabolism; D009153:Mutagens / Q000633:toxicity; D011817:Rabbits; D051381:Rats; D013662:Tea / Q000737:chemistry*
D016587:Antimutagenic Agents; D000975:Antioxidants; D044946:Biflavonoids; D004277:DNA, Single-Stranded; D009153:Mutagens; D013662:Tea; C056068:theaflavin; D002392:Catechin; D006861:Hydrogen Peroxide