title: Successful use of methadone in nociceptive cancer pain unresponsive to morphine.
abstract: Morphine is the mainstay of pain control in cancer patients. We describe three patients in whom adequate analgesia was not obtained with morphine, and discuss the role of morphine metabolites and the use of methadone as an alternative strong opioid analgesic.
authors.affiliation: Hospice of the Good Shepherd, Chester, UK.
authors.forename: G
authors.initials: G
authors.lastname: Leng
authors.forename: M J
authors.initials: MJ
authors.lastname: Finnegan
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008691:Methadone / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage* / Q000009:adverse effects; D009369:Neoplasms / Q000503:physiopathology*; D010147:Pain Measurement; D010148:Intractable Pain / Q000188:drug therapy*; D010166:Palliative Care / Q000379:methods*
chemical_list: D009020:Morphine; D008691:Methadone