Experimental cholesteatoma in the rat.
The etiology of cholesteatoma is still enigmatic. Of the current theories, none has been confirmed with adequately convincing evidence. A completely suitable animal model has not hitherto been available and there is still a need for further experimental studies of this entity. As a possible experimental model we suggest dimethyl-benzanthracene induced cholesteatoma in the rat.
Schmidt
S H
SH
Department of Otorhinolaryngology, University of Umeå, Sweden.
Hellström
S
S
D015127:9,10-Dimethyl-1,2-benzanthracene / Q000009:adverse effects*; D000818:Animals; D018424:Cholesteatoma, Middle Ear / Q000139:chemically induced* / Q000473:pathology; D004195:Disease Models, Animal; D004424:Ear Canal / Q000187:drug effects / Q000473:pathology; D004432:Ear, Middle / Q000187:drug effects / Q000473:pathology; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D005064:Eustachian Tube / Q000187:drug effects / Q000473:pathology; D007633:Keratins / Q000187:drug effects; D010035:Otitis Media, Suppurative / Q000139:chemically induced / Q000473:pathology; D051381:Rats; D017207:Rats, Sprague-Dawley; D014432:Tympanic Membrane / Q000187:drug effects / Q000473:pathology
D015127:9,10-Dimethyl-1,2-benzanthracene; D007633:Keratins