title: [Substantiation of the use of prostaglandin- and kininogenesis in general anesthesia and postoperative analgesia].
abstract: The expediency of introducing prostaglandin- and kininogenesis inhibitors (acelysin and kontrykal) into general anesthesia and postoperative analgesia has been substantiated and the advantages of the application of these specific nonopiate components of surgical analgesia have been shown. The above inhibitors alleviate local and general homeostasis disorders associated with excessive production of prostaglandins and kinins during surgical trauma and increase the efficacy of analgesia, reducing the need in narcotic analgesics.
authors.forename: N A
authors.initials: NA
authors.lastname: Osipova
authors.forename: S V
authors.initials: SV
authors.lastname: Sviridov
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000700:Analgesics / Q000627:therapeutic use*; D000768:Anesthesia, General; D007611:Aprotinin / Q000627:therapeutic use*; D001241:Aspirin / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D005998:Glycine / Q000627:therapeutic use*; D006801:Humans; D007705:Kinins / Q000096:biosynthesis; D008239:Lysine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D011453:Prostaglandins / Q000096:biosynthesis; D013997:Time Factors
chemical_list: D000700:Analgesics; D004338:Drug Combinations; D007705:Kinins; D011453:Prostaglandins; C076488:acetylsalicylate, glycine, lysine drug combination; D007611:Aprotinin; D008239:Lysine; D001241:Aspirin; D005998:Glycine