Detection of mutagenicity of diphenyl ether herbicides in Salmonella typhimurium YG1026 and YG1021.
Three kinds of diphenyl ether herbicides, 4-nitrophenyl 2,4,6-trichlorophenyl ether (CNP, chlornitrofen), 2,4-dichlorophenyl 3-methoxy-4-nitrophenyl ether (chlomethoxynil) and 2,4-dichlorophenyl 3-methoxycarbonyl-4-nitrophenyl ether (bifenox), were tested for mutagenicity in Salmonella typhimurium YG1026 and YG1021, which have high nitroreductase activity, and also in S. typhimurium TA100 and TA98. CNP and chlomethoxynil showed mutagenicity in S. typhimurium YG1026, without S9 mix, inducing 50 and 304 revertants per microgram. These mutagenicities were suppressed by the addition of S9 mix. CNP and chlomethoxynil were also mutagenic to YG1021 with and without S9 mix, and their mutagenicities were lower than those to YG1026. On the other hand, bifenox was mutagenic to YG1026 only with S9 mix, inducing 3.0 revertants per micrograms. These three herbicides showed no mutagenicity in S. typhimurium TA100 and TA98 either with or without S9 mix.
Oguri
A
A
Biochemistry Division, National Cancer Center Research Institute, Tokyo, Japan.
Karakama
K
K
Arakawa
N
N
Sugimura
T
T
Wakabayashi
K
K
D004305:Dose-Response Relationship, Drug; D006540:Herbicides / Q000494:pharmacology*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D010647:Phenyl Ethers / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics*; D013045:Species Specificity
D006540:Herbicides; D009153:Mutagens; D010647:Phenyl Ethers; C010422:2,4,6-trichlorophenyl 4-nitrophenyl ether; C050421:bifenox; C054410:chlormethoxynil