title: Photoneural regulation of rat pineal nitric oxide synthase.
abstract: We report here a photoneural regulation of nitric oxide synthase (NOS) activity in the rat pineal gland. In the absence of the adrenergic stimulation following constant light exposure (LL) or denervation, pineal NOS activity is markedly reduced. A maximal drop is measured after 8 days in LL. When rats are housed back in normal light:dark (LD) conditions (12:12), pineal NOS activity returns to normal after 4 days. A partial decrease in pineal NOS activity is also observed when rats are placed for 8 days in LD 18:6 or shorter dark phases, indicating that pineal NOS activity reflects the length of the dark phase. Because it is known that norepinephrine (NE) is released at night from the nerve endings in the pineal gland and this release is blocked by exposure to light, our data suggest that NOS is controlled by adrenergic mechanisms. Our observation may also explain the lack of cyclic GMP response to NE observed in animals housed in constant light.
authors.affiliation: Department of Psychiatry, Geneva University Medical School, Chêne-Bourg, Switzerland.
authors.forename: N C
authors.initials: NC
authors.lastname: Schaad
authors.forename: J
authors.initials: J
authors.lastname: Vanecek
authors.forename: P E
authors.initials: PE
authors.lastname: Schulz
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D005728:Ganglia, Sympathetic; D015171:Ganglionectomy; D008027:Light; D008297:Male; D009424:Nervous System Physiological Phenomena; D019001:Nitric Oxide Synthase; D017440:Photoperiod; D010870:Pineal Gland / Q000201:enzymology* / Q000294:innervation* / Q000528:radiation effects; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases