2-Nitropropane-induced liver DNA and RNA base modifications: differences between Sprague-Dawley rats and New Zealand white rabbits.
2-Nitropropane (2-NP), a hepatocarcinogen in male Sprague-Dawley rats but not, under the same conditions, in male New Zealand White rabbits, induces characteristic base modifications in rat liver DNA and RNA including increases in 8-oxoguanine and the formation of 8-aminoguanine. We compared the levels of these modifications in the two animal species at 6, 18 and 42 h after a single i.p. treatment with 1.12 mmol/kg 2-NP. Significantly less nucleic acid base modifications were found to be produced in rabbit liver than in rat liver. Thus, the relative resistance of the rabbit to the hepatocarcinogenicity of 2-NP correlates with decreased levels of 2-NP-induced liver DNA and RNA base damage.
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Division of Biochemical Pharmacology, American Health Foundation, Valhalla, NY 10595.
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Sodum
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Sohn
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D000818:Animals; D001711:Biotransformation; D002851:Chromatography, High Pressure Liquid; D004247:DNA / Q000187:drug effects; D004249:DNA Damage; D003849:Deoxyguanosine / Q000096:biosynthesis; D006151:Guanosine / Q000031:analogs & derivatives / Q000096:biosynthesis / Q000378:metabolism; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009153:Mutagens / Q000633:toxicity*; D009595:Nitroparaffins / Q000633:toxicity*; D009696:Nucleic Acids / Q000187:drug effects* / Q000378:metabolism; D009705:Nucleosides / Q000378:metabolism*; D011407:Propane / Q000031:analogs & derivatives* / Q000633:toxicity; D012313:RNA / Q000187:drug effects; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D013045:Species Specificity
D009153:Mutagens; D009595:Nitroparaffins; D009696:Nucleic Acids; D009705:Nucleosides; D006151:Guanosine; C032533:8-aminoguanosine; D012313:RNA; D004247:DNA; D003849:Deoxyguanosine; C016617:2-nitropropane; D011407:Propane