Modulation by polymyxin B of the effects of interferon on human myelogenous leukemia cells.
Natural and recombinant human interferon-alpha (IFN-alpha) and -gamma (IFN-gamma) exert differentiation-inducing and cytocidal effects in vitro on cells of the human myeloblastic leukemia cell line ML-2. These activities of IFNs are modulated by polymyxin B (PMB), a cyclic polycationic peptide antibiotic effective on Gram-negative bacilli. The modulating effect of PMB varies according to the species of IFN, namely, PMB enhances the activities of either natural IFN-gamma or recombinant IFN-gamma, while it inhibits the effects of either natural IFN-alpha or recombinant IFN-alpha. The cause of this variety in PMB effect on IFNs remains to be clarified.
Tamura
M
M
Hayashibara Biochemical Laboratories, Inc., Okayama, Japan.
Nagano
Y
Y
D002454:Cell Differentiation; D002470:Cell Survival; D004950:Esterases / Q000378:metabolism; D006801:Humans; D007370:Interferon Type I / Q000494:pharmacology; D016898:Interferon-alpha / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000819:agonists* / Q000037:antagonists & inhibitors*; D015470:Leukemia, Myeloid, Acute / Q000188:drug therapy*; D010587:Phagocytosis; D011112:Polymyxin B / Q000494:pharmacology*; D011994:Recombinant Proteins; D014407:Tumor Cells, Cultured
D007370:Interferon Type I; D016898:Interferon-alpha; D011994:Recombinant Proteins; D007371:Interferon-gamma; D007372:Interferons; D004950:Esterases; D011112:Polymyxin B