Comparative analysis of fluctuation of serum tumor markers in advanced cancer of prostate.
Serial serum prostate tumor markers (acid phosphatase, prostate-specific antigen-Yang, prostate-specific antigen-Hybritech, lipid-associated sialic acid in plasma, and tissue polypeptide antigen) were obtained every four hours during a twenty-four-hour interval from men with Stage D adenocarcinoma of the prostate. No therapeutic or diagnostic manipulations occurred during sample procurement, so that the amount of fluctuation in these serum prostate cancer markers could be determined. The average co-efficient of variation for acid phosphatase 28.8, prostate-specific antigen-Yang 8.85, prostate-specific antigen-Hybritech 7.2, lipid-associated sialic acid in plasma (LASA-P) 6.19, and tissue polypeptide antigen (TPA) 14.75 indicate that prostate-specific antigen determined by either method fluctuates minimally, indicating stability and, because it is prostate-cancer specific, is the most useful tumor marker tested.
Maatman
T J
TJ
Department of Urology, Michigan Urological Clinic, Grand Rapids.
D000135:Acid Phosphatase / Q000097:blood; D000230:Adenocarcinoma / Q000097:blood* / Q000473:pathology; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000097:blood*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid; D009367:Neoplasm Staging; D010455:Peptides / Q000097:blood; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology; D012794:Sialic Acids / Q000097:blood; D013997:Time Factors; D019396:Tissue Polypeptide Antigen
D014408:Biomarkers, Tumor; D008055:Lipids; D010455:Peptides; D012794:Sialic Acids; D019396:Tissue Polypeptide Antigen; C054080:lipid-associated sialic acid; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen; D019158:N-Acetylneuraminic Acid