Synthesis of antibodies against measles virus and myelin by in vitro stimulated B-cells derived from patients with subacute sclerosing panencephalitis.
Subacute sclerosing panencephalitis (SSPE) patients carry persistent measles virus infection in the brain. Furthermore, the blood lymphocytes contain viral RNA. Lymphocytes derived from 6 SSPE patients were stimulated with Epstein-Barr virus (EBV). Production of antibodies against measles virus of the IgG isotype was detected in the supernatants of cell cultures of all patients, regardless of the disease's activity, duration or interferon therapy. In contrast, only some of these cell cultures also produced antibodies against myelin.
Wirguin
I
I
Department of Neurology, Hadassah University Hospital, Jerusalem, Israel.
Steinitz
M
M
Sicsic
C
C
Abramsky
O
O
Brenner
T
T
D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000276:immunology*; D000918:Antibody Specificity; D001402:B-Lymphocytes / Q000276:immunology*; D002461:Cell Line, Transformed; D002478:Cells, Cultured; D002648:Child; D004660:Encephalitis / Q000276:immunology; D005260:Female; D005699:Galactosylceramides / Q000276:immunology*; D004854:Herpesvirus 4, Human; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology*; D008213:Lymphocyte Activation; D008297:Male; D008459:Measles virus / Q000276:immunology*; D009103:Multiple Sclerosis / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology*; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology; D013344:Subacute Sclerosing Panencephalitis / Q000097:blood / Q000134:cerebrospinal fluid / Q000276:immunology*
D000914:Antibodies, Viral; D005699:Galactosylceramides; D007074:Immunoglobulin G; D004676:Myelin Basic Protein; C002454:galactocerebroside