Isotype and antigen specificity of pertussis agglutinins following whole-cell pertussis vaccination and infection with Bordetella pertussis.
Elevated agglutinin titers have been shown to correlate with protection from disease following whole-cell pertussis vaccination, but the isotype and antigen specificity of human agglutinating antibodies is unknown. In 13 immunoassays, immunoglobulin G antifimbria antibodies had the strongest correlation with agglutinin titers following culture-proven infection with Bordetella pertussis (R' = 0.79; P < 0.0001) and following whole-cell pertussis vaccination (R' = 0.87, P < 0.0001).
Mink
C M
CM
Laboratory of Pertussis, Food and Drug Administration, Bethesda, Maryland.
O'Brien
C H
CH
Wassilak
S
S
Deforest
A
A
Meade
B D
BD
D000373:Agglutinins / Q000032:analysis*; D000907:Antibodies, Bacterial / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes; D006801:Humans; D007132:Immunoglobulin Isotypes / Q000032:analysis*; D010567:Pertussis Vaccine / Q000276:immunology*; D014611:Vaccination; D014917:Whooping Cough / Q000276:immunology*
D000373:Agglutinins; D000907:Antibodies, Bacterial; D000939:Epitopes; D007132:Immunoglobulin Isotypes; D010567:Pertussis Vaccine