title: Effect of finasteride on serum PSA concentration in men with benign prostatic hyperplasia. Results from the North American phase III clinical trial.
abstract: Finasteride, a 5-alpha reductase inhibitor recently introduced for the treatment of symptomatic benign prostatic hyperplasia, reduces prostate size and decreases serum PSA concentration. To interpret PSA in men treated with finasteride, it is necessary to take the reduction into account. This article describes the effect of finasteride on the serum PSA concentration in the North American Phase III clinical trial and discusses implications of these findings for the interpretation of serum PSA in men treated with finasteride.
authors.affiliation: Merck Research Laboratories, Rahway, New Jersey.
authors.forename: H A
authors.initials: HA
authors.lastname: Guess
authors.forename: J F
authors.initials: JF
authors.lastname: Heyse
authors.forename: G J
authors.initials: GJ
authors.lastname: Gormley
authors.forename: E
authors.initials: E
authors.lastname: Stoner
authors.forename: J E
authors.initials: JE
authors.lastname: Oesterling
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004311:Double-Blind Method; D018120:Finasteride / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood / Q000188:drug therapy*
chemical_list: D018120:Finasteride; D017430:Prostate-Specific Antigen