[Physiopathology of pruritus].
Itching is the predominant symptom of inflammatory skin diseases. Present evidence indicates that histamine and unidentified peptides mediate itching. No evidence is available that lymphokines or cytokines play a direct role as itch mediators. Prostaglandins serve an important synergistic function in itching. Evidence points to a role for opioid peptides of the central nervous system in the perception of itch and as direct mediators. Pruritus may be a prominent symptom in uraemia, biliary obstruction, atopic dermatitis and neoplasia.
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M
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Service de Dermatologie, Hôpitaux St Pierre et Brugmann, Bruxelles.
D006636:Histamine Release; D006801:Humans; D018847:Opioid Peptides / Q000502:physiology; D011458:Prostaglandins E / Q000502:physiology; D011537:Pruritus / Q000503:physiopathology*; D012871:Skin Diseases / Q000503:physiopathology*; D012881:Skin Temperature
D018847:Opioid Peptides; D011458:Prostaglandins E