The effects of clozapine on neurocognition: an overview.
Clozapine has proved effective in alleviating a wide range of psychiatric symptoms in schizophrenia. Its effects on cognitive function in schizophrenia are more variable. Clozapine appears to have a salutary effect on some aspects of attention, response speed, and fluency, whereas it appears to have a mild but adverse effect on visual memory and some executive functions. This profile may be related to the affinity of clozapine for dopaminergic type I and muscarinic receptors and relative lack of affinity for dopaminergic type II receptors.
Goldberg
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Clinical Brain Disorders Branch, National Institute of Mental Health Neurosciences Center, St. Elizabeths, Washington, D.C. 20032.
Weinberger
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D003024:Clozapine / Q000494:pharmacology* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects*; D003072:Cognition Disorders / Q000188:drug therapy / Q000523:psychology; D004298:Dopamine / Q000502:physiology; D006801:Humans; D007555:Isoxazoles / Q000494:pharmacology / Q000627:therapeutic use; D009483:Neuropsychological Tests; D010880:Piperidines / Q000494:pharmacology / Q000627:therapeutic use; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology; D018967:Risperidone; D012559:Schizophrenia / Q000188:drug therapy* / Q000503:physiopathology; D012565:Schizophrenic Psychology; D016896:Treatment Outcome
D007555:Isoxazoles; D010880:Piperidines; D011954:Receptors, Dopamine; D011976:Receptors, Muscarinic; D003024:Clozapine; D018967:Risperidone; D004298:Dopamine