Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.
Embelin, a plant-based benzoquinone derivative, has been found to exhibit significant antitumor activity in methylcholanthrene-induced fibrosarcoma in albino rats besides enhancing their survival time. The drug also has an appreciable action on pain and inflammation. The changes in DNA, RNA and protein levels in various organs in the tumor-bearing control and the drug-treated animals were also studied.
Chitra
M
M
Department of Biochemistry, University of Madras, India.
Sukumar
E
E
Suja
V
V
Devi
C S
CS
D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D016227:Benzoquinones / Q000494:pharmacology / Q000627:therapeutic use*; D004247:DNA / Q000378:metabolism; D005354:Fibrosarcoma / Q000188:drug therapy*; D008297:Male; D010146:Pain / Q000188:drug therapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016227:Benzoquinones; D010936:Plant Extracts; D011506:Proteins; D012313:RNA; D004247:DNA; C010945:embelin