Human AQP2 and MIP genes, two members of the MIP family, map within chromosome band 12q13 on the basis of two-color FISH.
The human AQP2 (collecting duct water channel, aquaporin 2) gene encodes a 271 amino acid protein and is a member of the MIP (major intrinsic protein of lens fiber) gene family. Using two-color fluorescence in situ hybridization on high-resolution R-banded chromosomes and human genomic DNA clones for AQP2 and MIP as probes, we found that both genes mapped closely within the human chromosome region 12q13.
Saito
F
F
Department of Cytogenetics, Tokyo Medical and Dental University, Japan.
Sasaki
S
S
Chepelinsky
A B
AB
Fushimi
K
K
Marumo
F
F
Ikeuchi
T
T
D000818:Animals; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D001426:Bacterial Proteins / Q000235:genetics*; D002478:Cells, Cultured; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D020104:Immunophilins; D017404:In Situ Hybridization, Fluorescence / Q000379:methods; D007473:Ion Channels / Q000235:genetics*; D008214:Lymphocytes / Q000166:cytology / Q000378:metabolism; D008565:Membrane Proteins / Q000235:genetics*; D005810:Multigene Family; D019696:Peptidylprolyl Isomerase
C496023:AQP2 protein, human; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D001426:Bacterial Proteins; D007473:Ion Channels; D008565:Membrane Proteins; D020104:Immunophilins; D019696:Peptidylprolyl Isomerase