title: Argyrophilic thread-like structure in corticobasal degeneration and supranuclear palsy.
abstract: Massive argyrophilic thread-like structures (ATS) are observed in corticobasal degeneration and, in varied degrees, in some cases of progressive supranuclear palsy. Immunohistochemically, ATS has a full length of phosphorylated tau epitopes without ubiquitin. Gallyas- and immuno-electron microscopic observation revealed that ATS is a cytoskeletal abnormality occurred in both the inner and outer loop of the oligodendroglia. tau-Positive oligodendroglial tangles were distributed in the same region as ATS.
authors.affiliation: Department of Neuropathology, Tokyo Institute of Psychiatry, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: H
authors.initials: H
authors.lastname: Akiyama
authors.forename: C
authors.initials: C
authors.lastname: Haga
authors.forename: H
authors.initials: H
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Arima
authors.forename: T
authors.initials: T
authors.lastname: Oda
mesh_terms: D000368:Aged; D001479:Basal Ganglia / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D009410:Nerve Degeneration; D013494:Supranuclear Palsy, Progressive / Q000473:pathology*; D016875:tau Proteins / Q000378:metabolism
chemical_list: D000939:Epitopes; D016875:tau Proteins