title: Specificity and editing by apoptosis of virus-induced cytotoxic T lymphocytes.
abstract: Recent studies have defined an immunological network by which the acute cytotoxic T-lymphocyte response to viral infection modulates or is modulated by the antigen load and by crossreactive memory T cells. Down regulation of the acute CTL response can be associated with either antigen-dependent or antigen-independent apoptosis, and the host enters a state of immune deficiency as these T cells become sensitized to apoptotic mechanisms.
authors.affiliation: Department of Pathology, University of Massachusetts Medical Center, North Worcester 01655-0125.
authors.forename: L K
authors.initials: LK
authors.lastname: Selin
authors.forename: R M
authors.initials: RM
authors.lastname: Welsh
mesh_terms: D000818:Animals; D017209:Apoptosis; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D007519:Isoantigens / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
chemical_list: D000939:Epitopes; D007519:Isoantigens