Specificity and editing by apoptosis of virus-induced cytotoxic T lymphocytes.
Recent studies have defined an immunological network by which the acute cytotoxic T-lymphocyte response to viral infection modulates or is modulated by the antigen load and by crossreactive memory T cells. Down regulation of the acute CTL response can be associated with either antigen-dependent or antigen-independent apoptosis, and the host enters a state of immune deficiency as these T cells become sensitized to apoptotic mechanisms.
Selin
L K
LK
Department of Pathology, University of Massachusetts Medical Center, North Worcester 01655-0125.
Welsh
R M
RM
D000818:Animals; D017209:Apoptosis; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D007156:Immunologic Memory; D007519:Isoantigens / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*
D000939:Epitopes; D007519:Isoantigens