[Hypothyroidism followed by hyperthyroidism under treatment with amiodarone].
Hypothyroidism followed by hyperthyroidism is described in two patients treated by amiodarone. Euthyroidism was rapidly restored after treatment with antithyroid drugs and potassium perchlorate. The physiopathology of amiodarone-induced hypothyroidism is discussed. Withdrawal of amiodarone is advised in the case of both hypothyroidism and hyperthyroidism.
Martin-Du Pan
R C
RC
Unité de la thyroïde, Hôpital cantonal, Genève.
Goumaz
M O
MO
Perrotet
C
C
Burger
A
A
D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects*; D013956:Antithyroid Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D007037:Hypothyroidism / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010472:Perchlorates / Q000627:therapeutic use; D017680:Potassium Compounds / Q000627:therapeutic use
D013956:Antithyroid Agents; D010472:Perchlorates; D017680:Potassium Compounds; C009006:potassium perchlorate; D000638:Amiodarone