Fas antigen and p55 TNF receptor signal apoptosis through distinct pathways.
The Fas Ag and the p55 TNF receptor (TNF-R1) are related molecules that can signal apoptosis. Some tumor cell lines are selectively killed by Fas activation and others by TNF-R1 activation even though both receptors are often co-expressed. TNF-R1-mediated cytotoxicity can be selectively inhibited under conditions in which Fas-mediated cell death is not affected. Activation of both receptors results in synergistic signaling of apoptosis. These results indicate that different biochemical pathways are activated by Fas and TNF-R1. Combination treatment with agonists of Fas and TNF-R1 may have therapeutic potential.
Wong
G H
GH
Department of Cardiovascular Research, Genentech, Inc., South San Francisco, CA 94080.
Goeddel
D V
DV
D000818:Animals; D000954:Antigens, Surface / Q000502:physiology*; D017209:Apoptosis; D002460:Cell Line; D003513:Cycloheximide / Q000494:pharmacology; D003602:Cytotoxicity, Immunologic; D006801:Humans; D051379:Mice; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology*; D019014:fas Receptor
D000954:Antigens, Surface; D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor; D003513:Cycloheximide