Characterization of anti-myeloperoxidase antibodies in vasculitis.
Anti-myeloperoxidase (MPO) antibodies are frequently encountered in patients with vasculitis. Using a competitive inhibition ELISA test and immunoblotting, we suggest that anti-MPO antibodies might represent a heterogenous group of auto-antibodies directed against different conformational epitopes of MPO molecule.
Tadros
M
M
Department of Nephrology, S. Carlo Hospital, Milan, Italy.
Pozzi
C
C
Radice
A
A
Sinico
R A
RA
D'Amico
G
G
D019268:Antibodies, Antineutrophil Cytoplasmic; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D006801:Humans; D015151:Immunoblotting; D007074:Immunoglobulin G / Q000097:blood / Q000276:immunology; D009195:Peroxidase / Q000276:immunology*; D014657:Vasculitis / Q000276:immunology*
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D000939:Epitopes; D007074:Immunoglobulin G; D009195:Peroxidase