title: Prevalence of antibodies to hepatitis C virus in populations at low and high risk for sexually transmitted diseases in Rio de Janeiro.
abstract: In order to investigate the sexual transmission of the Hepatitis C Virus (HCV), the prevalence of specific antibodies in populations at high and low risk for sexually transmitted diseases (STDs) was evaluated. The population at low risk for STDs was composed of persons who voluntarily donated blood at the Hospital Universitário Clementino Fraga Filho (HUCFF) between July and November, 1990 (n = 2494). The population at high risk for STDs was drawn from an ongoing study on the natural history of Human Immunodeficiency Virus (HIV) infection (n = 210, 187 with sexual risk factors for HIV infection). All samples were screened using a first generation ELISA. Repeat reactive samples were then tested in a second generation RIBA. For all ELISA positive samples, two sex and age-matched ELISA negative controls were selected. Data pertaining to the presence of antibodies to the Hepatitis B core antigen (anti-HBC antibodies) and to Treponema pallidum were abstracted from the medical records. The prevalence of RIBA 2 confirmed HCV infection among the blood donors was 2.08%, which is well above the reported prevalence in similar populations from developed western countries. Among the HIV infected homosexuals, the encountered prevalence was 7.96% (p < 0.0005). For the whole group with sexually acquired HIV infection, the prevalence was 8.02% (p < 0.000005). Anti-HBc antibodies were more frequently present in anti-HCV RIBA-2 confirmed positive blood donors than in controls (p < 0.001). 33.3% of the HCV-positive blood donors and 11.04% controls were found to be anti-HBc positive (p < 0.0005).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Laboratório de Pesquisas do Programa SIDA/AIDS, Hospital Universitário Clementino Fraga Filho, Rio de Janeiro, Brasil.
authors.forename: M
authors.initials: M
authors.lastname: Edelenyi-Pinto
authors.forename: A P
authors.initials: AP
authors.lastname: Carvalho
authors.forename: C
authors.initials: C
authors.lastname: Nogueira
authors.forename: O
authors.initials: O
authors.lastname: Ferreira Júnior
authors.forename: M
authors.initials: M
authors.lastname: Schechter
mesh_terms: D001782:Blood Donors; D001938:Brazil; D016174:Hepacivirus / Q000276:immunology; D006508:Hepatitis Antibodies / Q000032:analysis*; D006526:Hepatitis C / Q000175:diagnosis / Q000276:immunology*; D018937:Hepatitis C Antibodies; D006801:Humans; D015995:Prevalence; D012749:Sexually Transmitted Diseases / Q000276:immunology*
chemical_list: D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies