title: Does the mast cell have an intrinsic role in the pathogenesis of interstitial cystitis?
abstract: In order to examine the role of mast cells in the inflammatory bladder disease interstitial cystitis, mast cells isolated from the human bladder of normal and diseased tissue were challenged with a range of secretagogues. Calcium ionophore A23187 and anti-IgE caused histamine release from all bladder mast cells in a dose-related manner. Mast cells from the diseased tissue were far more responsive than those from the normal tissue. Mast cells from the muscle of normal bladder were responsive towards substance P and compound 48/80. However, mast cells from interstitial cystitis bladder did not release significant amounts of histamine with these two secretagogues.
authors.affiliation: Department of Chemistry, University College London, UK.
authors.forename: A M
authors.initials: AM
authors.lastname: Frenz
authors.forename: T J
authors.initials: TJ
authors.lastname: Christmas
authors.forename: F L
authors.initials: FL
authors.lastname: Pearce
mesh_terms: D000001:Calcimycin / Q000494:pharmacology; D003556:Cystitis / Q000473:pathology*; D006636:Histamine Release / Q000187:drug effects / Q000502:physiology; D006801:Humans; D007073:Immunoglobulin E / Q000494:pharmacology; D066298:In Vitro Techniques; D008407:Mast Cells / Q000502:physiology*; D009130:Muscle, Smooth / Q000166:cytology / Q000473:pathology; D013373:Substance P / Q000494:pharmacology; D001743:Urinary Bladder / Q000166:cytology / Q000473:pathology* / Q000502:physiology; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D013373:Substance P; D007073:Immunoglobulin E; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine