Anti-inflammatory activity of the bark of Hippocratea excelsa.
The ethanol extract of the plant Hippocratea excelsa was examined for its anti-inflammatory effects using several animal models. It produced significant inhibition of carrageenan-induced paw edema and reduced the weight of cotton pellet-induced granuloma at doses of 25-100 mg/kg. The extract was found to exert a protective effect on heat-induced erythrocyte lysis at concentrations of 25, 50 and 100 micrograms/ml. In chronic models of formaldehyde and adjuvant arthritis, its anti-arthritic activity was found to be less than that of phenylbutazone (PNB). It may be inferred that the ethanol extract is effective against both exudative-proliferative and chronic phases of inflammation.
Perez
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RM
Escuela Superior de Ingenieria Quimica e Industrias extractivas, I.P.N., México D.F., Mexico.
Perez
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Zavala
M A
MA
Salazar
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M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan / Q000008:administration & dosage / Q000633:toxicity; D004195:Disease Models, Animal; D004305:Dose-Response Relationship, Drug; D004487:Edema / Q000188:drug therapy; D004912:Erythrocytes / Q000187:drug effects / Q000473:pathology; D000431:Ethanol / Q000737:chemistry; D005557:Formaldehyde / Q000008:administration & dosage / Q000633:toxicity; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D006358:Hot Temperature / Q000009:adverse effects; D008297:Male; D010653:Phenylbutazone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014197:Trees
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D010936:Plant Extracts; D005557:Formaldehyde; D000431:Ethanol; D002351:Carrageenan; D010653:Phenylbutazone