Effects of B subunit of cholera toxin on histamine release from rat peritoneal mast cells.
We studied the effects of B subunit of cholera toxin (CTB) on secretagogue-induced histamine release from rat peritoneal mast cells. CTB inhibited the release of histamine in response to compound 48/80, but not in response to mastoparan, substance P, concanavalin A or ionophore A23187. The results suggest that CTB can be used as a tool for studying the cellular events involved in histamine release from mast cells.
Sugimoto
K
K
Department of Biomedical Food Research, National Institute of Health, Tokyo, Japan.
Kasuga
F
F
Kumagai
S
S
D000818:Animals; D002118:Calcium / Q000378:metabolism; D002478:Cells, Cultured; D002772:Cholera Toxin / Q000494:pharmacology*; D003285:Contractile Proteins; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology*; D008840:Microfilament Proteins / Q000235:genetics*; D010529:Peritoneal Cavity / Q000166:cytology; D051304:Profilins; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D003285:Contractile Proteins; D008840:Microfilament Proteins; C495740:Pfn1 protein, rat; D051304:Profilins; D003189:p-Methoxy-N-methylphenethylamine; D002772:Cholera Toxin; D002118:Calcium