title: Cadmium chloride induces dose-dependent increases in the frequency of micronuclei in mouse bone marrow.
abstract: The frequency of micronucleated polychromatic erythrocytes (MPCE) and normochromatic erythrocytes (MNCE) was studied in Swiss albino mice treated with 0, 0.025, 0.05, 0.1, 0.25, 0.5, 1 and 2 mg/kg body weight of cadmium chloride. It was observed that cadmium chloride induced a dose-dependent increase in the frequency of MPCE and MNCE. However, this increase was significant only after treatment with 0.05 mg/kg of CdCl2 (MPCE). The polychromatic and normochromatic erythrocyte ratio (PCE/NCE ratio) declined with the increase in CdCl2 dose and this depletion was dose-dependent. A significant decline was observed only after 0.25 mg/kg CdCl2. The dose-response relationship for all three parameters was linear-quadratic.
authors.affiliation: Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: G C
authors.initials: GC
authors.lastname: Jagetia
authors.forename: S K
authors.initials: SK
authors.lastname: Adiga
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000648:ultrastructure; D002104:Cadmium / Q000633:toxicity*; D019256:Cadmium Chloride; D002712:Chlorides / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D015162:Micronucleus Tests
chemical_list: D002712:Chlorides; D002104:Cadmium; D019256:Cadmium Chloride