title: The effect of TPP, theophylline and theobromine on the angiogenic activity of mononuclear leucocytes obtained from diabetic patients with proliferative retinopathy.
abstract: Tołpa Peat Preparation (TPP) administered in various doses does not influence the ability of mononuclear cells (MNC) obtained from diabetic patients with proliferative retinopathy to induce neovascularization response in H-LIA test. Methylxanthines (theophylline, theobromine) significantly decrease the angiogenic activity of these cells. The therapeutic value of these drugs in proliferative retinopathy should be evaluated.
authors.affiliation: Laboratory of Electron Microscopy, Institute of Biostructure, School of Medicine, Warsaw, Poland.
authors.forename: P
authors.initials: P
authors.lastname: Skopiński
authors.forename: M
authors.initials: M
authors.lastname: Zukowska
authors.forename: W
authors.initials: W
authors.lastname: Małkowska-Zwierz
authors.forename: D
authors.initials: D
authors.lastname: Radomska
authors.forename: D
authors.initials: D
authors.lastname: Retelska
authors.forename: D
authors.initials: D
authors.lastname: Kecik
authors.forename: M
authors.initials: M
authors.lastname: Domosławski
authors.forename: A
authors.initials: A
authors.lastname: Sobczyńska
authors.forename: M
authors.initials: M
authors.lastname: Pawińska
authors.forename: E
authors.initials: E
authors.lastname: Skopińska-Rózewska
mesh_terms: D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D002241:Carbohydrates / Q000494:pharmacology*; D002648:Child; D003930:Diabetic Retinopathy / Q000473:pathology*; D004338:Drug Combinations; D006801:Humans; D006812:Humic Substances / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic / Q000209:etiology*; D012987:Soil; D013805:Theobromine / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology*; D014574:Uronic Acids / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D002241:Carbohydrates; D004338:Drug Combinations; D006812:Humic Substances; D012987:Soil; C084029:Tolpa; D014574:Uronic Acids; D013806:Theophylline; D013805:Theobromine