title: Dedifferentiated chondrosarcoma with t(9;22)(q34;q11-12).
abstract: Translocation t(9;22)(q22-31;q11-12) is associated with the myxoid variant of chondrosarcoma. We present here a report of a patient with a dedifferentiated grade IV chondrosarcoma, which originated from the iliac bone and contained areas of grade I chondrosarcoma. There was no evidence of myxoid differentiation. The tumor had the karyotype 46,X,-X,t(9;22)(q34;q11-12), + mar[5]/52-61,x?,2-3 min,inc[9]/46,XX[2]. It is possible that the different breakpoints in the t(9;22) may reflect different histopathologic subgroups of chondrosarcoma.
authors.affiliation: Department of Medical Genetics, University of Helsinki, Finland.
authors.forename: M
authors.initials: M
authors.lastname: Tarkkanen
authors.forename: T
authors.initials: T
authors.lastname: Wiklund
authors.forename: M
authors.initials: M
authors.lastname: Virolainen
authors.forename: I
authors.initials: I
authors.lastname: Elomaa
authors.forename: S
authors.initials: S
authors.lastname: Knuutila
mesh_terms: D000368:Aged; D000782:Aneuploidy; D001859:Bone Neoplasms / Q000235:genetics* / Q000473:pathology; D002454:Cell Differentiation; D002813:Chondrosarcoma / Q000235:genetics* / Q000473:pathology; D002869:Chromosome Aberrations; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22 / Q000648:ultrastructure*; D002899:Chromosomes, Human, Pair 9 / Q000648:ultrastructure*; D005260:Female; D006801:Humans; D007085:Ilium; D007621:Karyotyping; D014178:Translocation, Genetic; D014960:X Chromosome