Successful resolution of persistent trophoblastic disease after partial mole with the EMA-CO regimen.
A 29-year-old nullipara with partial hydatidiform mole at 8 weeks had pre-evacuation hCG levels of 275,000 mIU/ml. Free beta-hCG levels were measured as 3% (normal value below 4%). The patient developed persistent gestational trophoblastic disease, failed to respond to methotrexate and actinomycin D, but has responded to combination chemotherapy with EMA-CO. Such a response to EMA-CO was not reported previously.
Dgani
R
R
Department of Obstetrics and Gynecology, Kaplan Hospital, Rehovot, Israel.
Zalel
Y
Y
Biran
H
H
Blickstein
I
I
Caspi
B
B
Weissman
A
A
Shoham
Z
Z
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D006063:Chorionic Gonadotropin / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human; D003520:Cyclophosphamide / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage / Q000627:therapeutic use; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D006801:Humans; D006828:Hydatidiform Mole / Q000150:complications* / Q000601:surgery; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use; D010446:Peptide Fragments / Q000097:blood; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000209:etiology; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000150:complications* / Q000188:drug therapy / Q000601:surgery; D014619:Vacuum Curettage; D014750:Vincristine / Q000008:administration & dosage
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D003609:Dactinomycin; D014750:Vincristine; D005047:Etoposide; D003520:Cyclophosphamide; D008727:Methotrexate