A cultural study on corneal explants and clinic assessment of the effectiveness of treating corneal ulcers induced by alkal test with topic aprotinin and fibronectin.
The A.A. studied the effectiveness of colliriums containing fibronectins aprotinin, and fibronectin associated with aprotinin compared to a placebo using 12 rabbits in which a deep corneal ulcer was induced by alkal. The results showed the same effectiveness of the three collyrium versus the placebo there was clinical recovery in all cases and restoration of corneal trasparency for 13 out of 15 treated eyes. Cellular cultures obtained from primary explants of treated corneal cells, compared with non treated groups, gave the same outcome of the clinical's ones.
Cosimi
M F
MF
Department of Pathology City Hospital U.S.S.L., Alessandria.
Cerqueti
M P
MP
Lomolino
G
G
Re
P
P
Casagranda
I
I
D000287:Administration, Topical; D000818:Animals; D007611:Aprotinin / Q000627:therapeutic use*; D002478:Cells, Cultured; D003320:Corneal Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004359:Drug Therapy, Combination; D005353:Fibronectins / Q000627:therapeutic use*; D009883:Ophthalmic Solutions; D011817:Rabbits; D012972:Sodium Hydroxide
D005353:Fibronectins; D009883:Ophthalmic Solutions; D012972:Sodium Hydroxide; D007611:Aprotinin