[Chemotherapy and radiochemotherapy of colorectal cancers: adjuvant and palliative therapeutic procedures].
Palliative treatment in metastatic colorectal carcinoma is primarily based on 5-fluorouracil. The remission rates have been improved by biomodulation and by continuous infusion of 5-FU. Adjuvant treatment for carcinoma of the colon and rectum is used in subgroups of patients in order to improve the results of surgical treatment. After curative resection of a colonic carcinoma with lymph node metastasis (TNM stage III) treatment with levamisole and 5-FU is indicated. As the risk of local failure is increased in carcinoma of the rectum adjuvant pelvic radiation therapy is used, eventually combined with systemic chemotherapy. In order to define the subgroups of patients who might profit by palliative or adjuvant treatment and in order to develop more effective combination therapies patients should be entered into prospective randomized trials.
Porschen
R
R
Abteilung Innere Medizin I, Eberhard-Karls-Universität Tübingen.
Bermann
A
A
D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D003131:Combined Modality Therapy; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D009367:Neoplasm Staging; D010166:Palliative Care; D018714:Radiotherapy, Adjuvant
D000970:Antineoplastic Agents; D005472:Fluorouracil