Plasma granulocyte-colony stimulating factor concentrations ([G-CSF]) in the early neonatal period.
We studied G-CSF concentrations ([G-CSF]) at birth and their relationship with neutrophil count, incidence of infection, gestational age, labour, and the presence of maternal pregnancy-induced hypertension. Plasma [G-CSF] were significantly elevated in babies with suspected infection and in those of hypertensive mothers, compared to healthy babies delivered by elective caesarian section (median [range] = 3101 [75- > 5000] pg/ml and 153 [45-857] pg/ml versus 32 [11-266] pg/ml; P < 0.0001); and were unrelated to neutrophil count and gestational age. Initial high concentrations (> 100 pg/ml) declined by 7 d (P < 0.0001).
Russell
A R
AR
Department of Child Health, St George's Hospital Medical School, London.
Davies
E G
EG
McGuigan
S
S
Scopes
G J
GJ
Daly
S
S
Gordon-Smith
E C
EC
D000375:Aging / Q000097:blood; D002585:Cesarean Section; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D006973:Hypertension / Q000097:blood*; D007231:Infant, Newborn / Q000097:blood*; D007239:Infections / Q000097:blood*; D008431:Maternal-Fetal Exchange / Q000502:physiology; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000097:blood*; D011251:Pregnancy Complications, Infectious / Q000097:blood
D016179:Granulocyte Colony-Stimulating Factor