Improvement of patency in small veins following dextran and/or low-molecular-weight heparin treatment.
A clinical dose of dextran 70 had significant antithrombotic effects in small, severely traumatized veins, and the effect was enhanced by the addition of low-molecular-weight heparin. These effects were achieved without bleeding problems in this model.
Zhang
B
B
Department of Experimental Research, Malmö General Hospital, Sweden.
Wieslander
J B
JB
D000818:Animals; D003911:Dextrans / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D015951:Factor Xa / Q000378:metabolism; D006400:Hematocrit; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D008297:Male; D010314:Partial Thromboplastin Time; D011817:Rabbits; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy*; D014654:Vascular Patency / Q000187:drug effects*; D014680:Veins / Q000187:drug effects / Q000503:physiopathology
D003911:Dextrans; D006495:Heparin, Low-Molecular-Weight; D015951:Factor Xa