title: An intraperitoneal tumorous mass caused by granulomas of microfibrillar collagen hemostat (Avitene).
abstract: Microfibrillar collagen hemostat (Avitene) is an absorbable topical hemostatic agent prepared from purified bovine corium collagen. Herein, we report the case of a 56-year-old woman who had undergone an ovariohysterectomy for an ovarian mucinous cystadenocarcinoma 3 months previously and then required a second operation for an intraperitoneal mass associated with microfibrillar collagen hemostat. Microscopically, the resected mass was composed mostly of foreign-body granulomas with microfibrillar collagen hemostat materials. Microfibrillar collagen hemostat was used to control bleeding during the first operation. In a very small portion, however, a recurrent mucinous cystadenocarcinoma was also present. This case is worthy of note in that microfibrillar collagen hemostat may produce huge granulomatous masses that clinically mimic a neoplasm, inducing unnecessary and extensive treatment.
authors.affiliation: Department of Internal Medicine, Kawasaki Medical School, Kurashiki, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Kamei
authors.forename: K
authors.initials: K
authors.lastname: Tomimatu
authors.forename: T
authors.initials: T
authors.lastname: Manabe
mesh_terms: D003094:Collagen / Q000009:adverse effects* / Q000648:ultrastructure; D018282:Cystadenocarcinoma, Mucinous / Q000601:surgery; D003937:Diagnosis, Differential; D005260:Female; D015745:Granuloma, Foreign-Body / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007044:Hysterectomy; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010051:Ovarian Neoplasms / Q000601:surgery; D010052:Ovariectomy; D010534:Peritoneal Neoplasms / Q000175:diagnosis; D014057:Tomography, X-Ray Computed
chemical_list: D003094:Collagen