Treatment of linear localized scleroderma with the anti-allergic drug, tranilast.
A 14-year-old boy with linear localized scleroderma had a dramatic improvement in contractures after treatment with N-(3',4'-dimethoxycinnamoyl) anthranilic acid (tranilast, Rizaben). The observation that this anti-allergic drug was effective in localized scleroderma lends further support to the concept that mast cells play a role in increased collagen synthesis in this disease.
Taniguchi
S
S
Department of Dermatology, Osaka City University Medical School, Japan.
Yorifuji
T
T
Hamada
T
T
D000293:Adolescent; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006801:Humans; D007866:Leg; D008297:Male; D009068:Movement; D012594:Scleroderma, Localized / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology; D014033:Toe Joint / Q000503:physiopathology; D062367:ortho-Aminobenzoates / Q000627:therapeutic use*
D006634:Histamine H1 Antagonists; D062367:ortho-Aminobenzoates; C012293:tranilast