Effects of adenosine on chronotropic responses of rat atria to alpha and beta adrenergic stimulation.
The chronotropic response of rat atria to beta adrenergic stimulation required higher concentrations of agonist in the presence of adenosine. This anti beta-adrenergic effect could attenuate the tachycardia induced by the increased sympathetic tone during cardiac ischemia. The sensitivity to alpha adrenergic stimulation did not change in the presence of adenosine.
Gende
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Centro de Investigationes Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Argentina.
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D010656:Phenylephrine / Q000494:pharmacology*; D011224:Prazosin / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar
D010656:Phenylephrine; D000241:Adenosine; D011224:Prazosin