title: Methotrexate-induced leukoencephalopathy. A case report.
abstract: A six-year-old girl with non-Hodgkin's lymphoma who was treated with both intravenous (IV) and intrathecal (IT) methotrexate and developed brain damage secondary to the cytostatic drug is described. This patient displayed hypertension, hypothermia/hyperthermia, lethargy, deterioration and coma as clinical findings, and bilateral, focal white matter hyperintensities in the occipital lobes were seen in her magnetic resonance imaging (MRI). Treatment-related leukoencephalopathy is one such adverse effect of IT methotrexate administration on the central nervous system and usually appears in a generalized form.
authors.affiliation: Department of Pediatrics, Hacettepe University Faculty of Medicine, Ankara.
authors.forename: I
authors.initials: I
authors.lastname: Ilhan
authors.forename: A
authors.initials: A
authors.lastname: Cila
authors.forename: M
authors.initials: M
authors.lastname: Büyükpamukçu
authors.forename: C
authors.initials: C
authors.lastname: Akyüz
authors.forename: T
authors.initials: T
authors.lastname: Kutluk
authors.forename: S
authors.initials: S
authors.lastname: Berberoğlu
mesh_terms: D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects*; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008279:Magnetic Resonance Imaging; D008727:Methotrexate / Q000009:adverse effects*; D014057:Tomography, X-Ray Computed
chemical_list: D000964:Antimetabolites, Antineoplastic; D008727:Methotrexate