[Sequential monitoring of various HCV-related markers in chronic hepatitis C with interferon treatment].
Interferon (IFN) which is a powerful antiviral cytokine is capable to cure approximately 40% of patients with chronic hepatitis C. We should like to know in detail whether IFN is operating enough to improve chronic hepatitis C during IFN treatment. Therefore it was evaluated what kind of HCV related markers were important to monitor the clinical course. We discussed HCV-RNA (RT-PCR, DNA probe assay) and some antibodies to HCV including our new IgM antibody to a HCV core peptide, cp14 (amino acid 5-40 of the core protein). HCV-RNA assayed by RT-PCR was considered best to monitor the therapeutic effect of IFN on chronic hepatitis C. However, as it is still not in general, IgM anti-cp14 might be an alternative in monitoring the response to IFN in patients with chronic hepatitis C.
Nagayama
R
R
First Department of Medicine, Teikyo University School of Medicine.
Shoji
S
S
Miyake
K
K
D015415:Biomarkers / Q000032:analysis*; D002908:Chronic Disease; D015342:DNA Probes; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology; D006508:Hepatitis Antibodies / Q000032:analysis; D006526:Hepatitis C / Q000628:therapy*; D018937:Hepatitis C Antibodies; D006801:Humans; D007075:Immunoglobulin M / Q000032:analysis; D007372:Interferons / Q000627:therapeutic use*; D008991:Monitoring, Physiologic; D012367:RNA, Viral; D016896:Treatment Outcome; D014758:Viral Core Proteins / Q000032:analysis
D015415:Biomarkers; D015342:DNA Probes; D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D007075:Immunoglobulin M; D012367:RNA, Viral; D014758:Viral Core Proteins; C069130:nucleocapsid protein, Hepatitis C virus; D007372:Interferons