Acute systemic vanadate poisoning presenting as cerebrovascular ischemia with prolonged reversible neurological deficits (PRIND).
A 22-year-old woman is reported who attempted suicide by oral ingestion of approximately 10-15 g ammonium metavanadate (NH4VO3). A few hours later she developed gastrointestinal symptoms followed by a transient right sensomotor hemiparesis and aphasic disturbances. Brain MRI and SPECT with 99mTc-HMPAO revealed a lesion in the left parietal cortex. Plasmapheresis, ascorbic acid and desferoxamine led to a complete clinical recovery within a few days.
Schlake
H P
HP
Department of Neurosurgery, University of Würzburg, Germany.
Bertram
H P
HP
Husstedt
I W
IW
Schuierer
G
G
D000328:Adult; D001037:Aphasia / Q000139:chemically induced; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D002546:Ischemic Attack, Transient / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D008657:Metabolic Clearance Rate / Q000502:physiology; D009460:Neurologic Examination / Q000187:drug effects; D013406:Suicide, Attempted; D014638:Vanadates / Q000493:pharmacokinetics / Q000506:poisoning*
D014638:Vanadates