Constitutional trisomy 8 and myelodysplasia: report of a case and review of the literature.
A diagnosis of myelodysplastic syndrome was made in an 18-year-old patient with Warkany syndrome due to constitutional trisomy 8 mosaicism. The possible causal role of this particular chromosome constitution with respect to myelodysplasia and embryonal childhood tumors is discussed.
Zollino
M
M
Istituto di Genetica Medica, Università Cattolica del Sacro Cuore, Roma, Italy.
Genuardi
M
M
Bajer
J
J
Tornesello
A
A
Mastrangelo
S
S
Zampino
G
G
Mastrangelo
R
R
Neri
G
G
D000293:Adolescent; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D014314:Trisomy