[Streptomycin-induced severe aplastic anemia successfully treated with high-dose methylprednisolone pulse therapy and rhG-CSF].
An 83-year-old male was admitted with pulmonary tuberculosis. He was started on rifampicin, isoniazid, and streptomycin (SM). The hematological data at 12 weeks after the treatment showed pancytopenia (RBC: 2.14 x 10(6)/microliters, Hb: 7.2g/dl, Plt: 1.8 x 10(4)/microliters, WBC: 700/microliters). All the above medicines were discontinued and he received bolus methylprednisolone (bmPSL) and recombinant human granulocyte-colony stimulating factor (rhG-CSF). After 3 cycles of bmPSL, red blood cells and platelets gradually increased. White blood cells also increased in response to rhG-CSF. Bone marrow aspirate and biopsy specimens showed normocellularity, indicating recovery from aplastic anemia. Drug lymphocyte stimulation test was positive for SM.
Umeno
Y
Y
Department of Internal Medicine, Saga Prefectural Kohseikan Hospital.
Miyamoto
Y
Y
Ohta
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D000741:Anemia, Aplastic / Q000139:chemically induced* / Q000628:therapy*; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage*; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D011994:Recombinant Proteins / Q000627:therapeutic use; D013307:Streptomycin / Q000009:adverse effects*
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D008775:Methylprednisolone; D013307:Streptomycin