Time-dependent changes in platelet aggregation, fibrinolytic activity, and peripheral serotonergic measures in rats subjected to water immersion restraint stress.
The effects of water immersion restraint stress on collagen-induced platelet aggregation in whole blood, and on the fibrinolytic and serotonergic systems in rats have been studied. One hour long stress caused a release of tissue plasminogen activator (tPA) into the blood and a shortening of euglobulin clot lysis time (ECLT), whereas restraint of longer duration was responsible for a reduction in platelet aggregation, an elevation in the activity of plasminogen activator inhibitor with a concomitant fall in tPA and a prolongation of ECLT relative to controls. Whole-blood and plasma serotonin and its metabolite 5-hydroxyindoleacetic acid were also higher in the stressed rats and whole-blood serotonin level showed a negative correlation with tPA in the stressed rats. Either stress and/or its duration are responsible for changes in both fibrinolytic and serotonergic systems.
Malyszko
J
J
Department of Physiology, Hamamatsu University School of Medicine, Shizuoka, Japan.
Urano
T
T
Takada
Y
Y
Takada
A
A
D000208:Acute Disease; D000818:Animals; D005342:Fibrinolysis / Q000502:physiology*; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D007101:Immersion; D008297:Male; D010974:Platelet Aggregation / Q000502:physiology*; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D012701:Serotonin / Q000502:physiology*; D013312:Stress, Physiological / Q000097:blood*; D013997:Time Factors; D014867:Water
D014867:Water; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid