Successful reversal of neutropenia in Felty's syndrome with recombinant granulocyte colony stimulating factor.
We report two patients with Felty's syndrome and chronic skin ulcers treated successfully with recombinant granulocyte colony stimulating factor (GCSF). In both cases granulocytes returned to the normal range within days of starting treatment, and their cutaneous ulcers improved. In one patient granulocytes were maintained at normal levels with a regimen of GCSF 3 micrograms/kg twice weekly for 14 months.
Choi
M F
MF
Department of Medicine, University of Alberta, Canada.
Mant
M J
MJ
Turner
A R
AR
Akabutu
J J
JJ
Aaron
S L
SL
D000368:Aged; D005258:Felty Syndrome / Q000150:complications / Q000628:therapy*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012883:Skin Ulcer / Q000209:etiology
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor