title: [Drug distribution and antitumor effect of bleomycin incorporated in poly DL-lactic acid in rats].
abstract: Two bleomycin (BLM)-containing agents (BLM-PLA, BLM-SOL) were prepared, and the drug distribution and antitumor effect were studied. BLM-PLA is an agent in which BLM is incorporated into biodegradable low-molecular-weight polylactic acid, and BLM-SOL is an aqueous solution of BLM. BLM-PLA or BLM-SOL was subcutaneously administered in the back of rats. When BLM-PLA was implanted, high BLM activity of the connective tissues near the implants was maintained for 2 weeks. On the other hand, BLM activity was very low when BLM-SOL was administered. The effects of BLM-PLA, BLM-SOL and nontreatment on tumor growth and survival time were compared using subcutaneous tumor of Yoshida sarcoma in 21 rats each. The survivors and mean survival time in BLM-PLA group, BLM-SOL group and nontreatment group was 14 and 44.6 days, 5 and 23.7 days, and 0 and 11.3 days, respectively. BLM-PLA was superior to BLM-SOL in both drug distribution and antitumor effect, and consequently BLM-PLA could be a useful tool in loco-regional chemotherapy.
authors.affiliation: First Dept. of Surgery, Kagoshima University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Kumanohoso
authors.forename: S
authors.initials: S
authors.lastname: Natsugoe
authors.forename: K
authors.initials: K
authors.lastname: Tokuda
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: M
authors.initials: M
authors.lastname: Sagara
authors.forename: T
authors.initials: T
authors.lastname: Shinkawa
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Yamada
authors.forename: H
authors.initials: H
authors.lastname: Fukuzaki
authors.forename: T
authors.initials: T
authors.lastname: Aikou
mesh_terms: D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D007773:Lactates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011108:Polymers / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D012517:Sarcoma, Yoshida / Q000378:metabolism* / Q000473:pathology; D014018:Tissue Distribution
chemical_list: D003692:Delayed-Action Preparations; D007773:Lactates; D011108:Polymers; D001761:Bleomycin