Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systemic Candida albicans infections in normal and immunosuppressed mice.
SK&F 107647, a novel synthetic dimeric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in gamma irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu "nude" mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.
DeMarsh
P L
PL
Department of Anti-Infectives, Smithkline Beecham Pharmaceuticals, King of Prussia, PA 19406.
Sucoloski
S K
SK
Frey
C L
CL
Bhatnagar
P K
PK
Koltin
Y
Y
Actor
P
P
Petteway
S R
SR
D000818:Animals; D002177:Candidiasis / Q000276:immunology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005720:Gamma Rays / Q000009:adverse effects; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007165:Immunosuppression Therapy; D007375:Interleukin-1 / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009842:Oligopeptides / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D015996:Survival Rate
D007375:Interleukin-1; D009842:Oligopeptides; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; C086049:SK&F 107647