Stabilization of inducible nitric oxide synthase by monoclonal antibodies.
We have produced 14 monoclonal antibodies to inducible nitric oxide synthase purified from rat peritoneal cytotoxic activated macrophages. None of the antibodies showed neutralizing activity, but some of them enhanced the enzyme activity through stabilization of the enzyme.
Hattori
R
R
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Kosuga
K
K
Eizawa
H
H
Sase
K
K
Inoue
R
R
Sunamoto
M
M
Ichimori
Y
Y
Sato
K
K
Mori
T
T
Takahashi
K
K
D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis* / Q000276:immunology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D015153:Blotting, Western; D004790:Enzyme Induction; D005260:Female; D006801:Humans; D006825:Hybridomas; D007150:Immunohistochemistry; D007223:Infant; D051379:Mice; D008807:Mice, Inbred BALB C; D019001:Nitric Oxide Synthase; D051381:Rats; D017208:Rats, Wistar
D000911:Antibodies, Monoclonal; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases