Curative effects on rat sarcomas obtained after a treatment combining two monoclonal antibodies.
The effects of a treatment involving two monoclonal antibodies (Ab) were evaluated on benzo(a)pyrene [B(a)P]-induced malignant sarcomas in Sprague-Dawley female rats. These Ab were, respectively, an anti-anti-conjugated B(a)P AB, an internal image of conjugated B(a)P, called AIB1, and an anti-conjugated L-DOPA Ab. They were biweekly injected into animals with small clinically palpable tumors. Anti-'phosphatidylinositol-like' autoantibody (autoAb) levels which were significantly higher in B(a)P-treated rat sera were decreased after Ab treatment. Tumor growth was slowed down compared with that of controls and animal survival was increased. This treatment was more efficient than that involving AIB1 alone. The anti-conjugated L-DOPA Ab may play a role in neovascularization, which is known to be critical for tumor growth.
Chagnaud
J L
JL
Laboratoire d'Immunologie et Pathologie, Université de Bordeaux II, France.
Faiderbe
S
S
Geffard
M
M
D000818:Animals; D000911:Antibodies, Monoclonal / Q000378:metabolism / Q000494:pharmacology*; D001323:Autoantibodies / Q000378:metabolism; D005260:Female; D007167:Immunotherapy; D000922:Immunotoxins / Q000494:pharmacology*; D007980:Levodopa / Q000494:pharmacology*; D009389:Neovascularization, Pathologic / Q000628:therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D012513:Sarcoma, Experimental / Q000098:blood supply / Q000276:immunology / Q000628:therapy*
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D000922:Immunotoxins; D007980:Levodopa