Cardiac response to autonomic drugs in atria of diabetic mouse.
Comparisons of chronotropic effects of sympathomimetic and parasympathomimetic agents were made in isolated atria from alloxan-induced diabetic and age-matched control mice. In atria from mice rendered diabetic for three months, the cardiac response to bethanechol was potentiated compared with that of the age-matched control atria. However, the cardiac responses of atria from alloxan-treated mice to noradrenaline, 3-isobutyl-1-methyl-xanthine and 1,1-dimethyl-4-phenyl piperazinium iodide were similar to those of the controls.
Wong
K K
KK
Institute of Pharmacology, National Yang Ming Medical College, Taipei, Taiwan, Republic of China.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology*; D000496:Alloxan; D000818:Animals; D018723:Bethanechol / Q000494:pharmacology*; D001786:Blood Glucose / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D004246:Dimethylphenylpiperazinium Iodide / Q000494:pharmacology*; D006321:Heart / Q000187:drug effects*; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D051379:Mice; D008813:Mice, Inbred ICR; D009638:Norepinephrine / Q000494:pharmacology*
D001786:Blood Glucose; D018723:Bethanechol; D004246:Dimethylphenylpiperazinium Iodide; D000496:Alloxan; D015056:1-Methyl-3-isobutylxanthine; D009638:Norepinephrine