Stimulation of adenosine A2a receptors in the rat striatum induces catalepsy that is reversed by antagonists of N-methyl-D-aspartate receptors.
Bilateral infusion of the selective adenosine A2a agonist CGS 21680C (1 microgram per side) into the anterodorsal striatum of rats produced profound catalepsy. Intraperitoneal coadministration of the non-competitive N-methyl-D-aspartate (NMDA) antagonist dizocilpine (0.16 mg/kg) or the competitive NMDA antagonist CGP 37849 (4 mg/kg) completely reversed CGS 21680C-induced catalepsy, while lower doses of both NMDA antagonists induced no or only weak anticataleptic effects. The adenosine A2a receptor localization to striatopallidal neurons suggests that a selective activation of the striatopallidal efferent pathway is involved in the expression of catalepsy induced by intrastriatal infusion of CGS 21680C. In addition, striatopallidal neurons seem to be an important neuronal substrate of the anticataleptic effects of NMDA antagonists.
Hauber
W
W
Department of Animal Physiology, University of Stuttgart, Germany.
Münkle
M
M
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives / Q000494:pharmacology; D000241:Adenosine / Q000031:analogs & derivatives / Q000494:pharmacology; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy*; D003342:Corpus Striatum / Q000187:drug effects*; D016291:Dizocilpine Maleate / Q000494:pharmacology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D005917:Globus Pallidus / Q000187:drug effects; D008297:Male; D009434:Neural Pathways / Q000187:drug effects; D018696:Neuroprotective Agents / Q000494:pharmacology; D010627:Phenethylamines / Q000494:pharmacology; D058906:Purinergic P1 Receptor Agonists; D051381:Rats; D017207:Rats, Sprague-Dawley; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*; D013268:Stimulation, Chemical
D000927:Anticonvulsants; D018691:Excitatory Amino Acid Antagonists; D018696:Neuroprotective Agents; D010627:Phenethylamines; D058906:Purinergic P1 Receptor Agonists; D016194:Receptors, N-Methyl-D-Aspartate; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; C064539:2-amino-4-methyl-5-phosphono-3-pentenoic acid; D016291:Dizocilpine Maleate; D015763:2-Amino-5-phosphonovalerate; D000241:Adenosine