Clastogenicity of red pepper (Capsicum frutescens L.) extracts.
Extracts from the fruits of Capsicum frutescens L. were tested for their clastogenicity using the mouse-bone-marrow micronucleus (mouse-MN) assay. Results of the mouse-MN, an in vivo method, indicated that the isolate CF-1 is clastogenic at the maximum tolerated dose of 1.22 mg/kg mouse. Statistical analysis using the Wilcoxon two-sample test showed that the null hypothesis, mu tetracycline = muCF-1, is acceptable at 0.05 and 0.01 degrees of significance. Hence, the clastogenicity of CF-1 is statistically similar to that of tetracycline, a known clastogen, at the 5% and 1% levels of significance.
Villaseñor
I M
IM
Institute of Chemistry, University of the Philippines, Diliman, Quezon City.
de Ocampo
E J
EJ
D000473:Alkanes / Q000633:toxicity; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002211:Capsaicin / Q000737:chemistry / Q000633:toxicity*; D002212:Capsicum / Q000737:chemistry; D005591:Chemical Fractionation; D051379:Mice; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000737:chemistry / Q000633:toxicity*; D010946:Plants, Medicinal
D000473:Alkanes; D009153:Mutagens; D010936:Plant Extracts; C024713:n-tetradecane; D002211:Capsaicin