title: Transdermal scopolamine for reduction of drooling in developmentally delayed children.
abstract: Ten developmentally delayed children with excessive drooling were randomized in a double-blind, placebo-controlled study to assess the efficacy and safety of transdermal scopolamine. Over half of the patients had a statistically significant reduction in drooling, and one-third had cessation of drooling, while wearing the scopolamine patch. This short-term study supports earlier reports of the safety and efficacy of transdermal scopolamine for reducing excessive drooling in developmentally disabled children.
authors.affiliation: Department of Pediatrics and Neurology, US Naval Hospital, Portsmouth, VA 23708.
authors.forename: D W
authors.initials: DW
authors.lastname: Lewis
authors.forename: C
authors.initials: C
authors.lastname: Fontana
authors.forename: L K
authors.initials: LK
authors.lastname: Mehallick
authors.forename: Y
authors.initials: Y
authors.lastname: Everett
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D002648:Child; D002658:Developmental Disabilities / Q000150:complications*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D012601:Scopolamine / Q000627:therapeutic use*; D012798:Sialorrhea / Q000188:drug therapy* / Q000209:etiology
chemical_list: D010919:Placebos; D012601:Scopolamine