Swertifrancheside, an HIV-reverse transcriptase inhibitor and the first flavone-xanthone dimer, from Swertia franchetiana.
The first flavone-xanthone C-glucoside, swertifrancheside, was isolated from Swertia franchetiana, and its structure was elucidated on the basis of spectroscopic analysis as 1,5,8-trihydroxy-3-methoxy-7-(5',7',3'',4''- tetrahydroxy-6'-C-beta-D-glucopyranosyl-4'-oxy-8'-flavyl)-xanthone . This compound was a moderately potent inhibitor of HIV reverse transcriptase.
Wang
J N
JN
Department of Phytochemistry, Institute of Medicinal Plant Development, Beijing, People's Republic of China.
Hou
C Y
CY
Liu
Y L
YL
Lin
L Z
LZ
Gil
R R
RR
Cordell
G A
GA
D000962:Antimalarials / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D004354:Drug Screening Assays, Antitumor; D005419:Flavonoids / Q000302:isolation & purification* / Q000494:pharmacology; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000201:enzymology*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D010946:Plants, Medicinal / Q000737:chemistry*; D018894:Reverse Transcriptase Inhibitors; D014966:Xanthenes / Q000302:isolation & purification* / Q000494:pharmacology; D044004:Xanthones
D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D005419:Flavonoids; D018894:Reverse Transcriptase Inhibitors; D014966:Xanthenes; D044004:Xanthones; C087101:swertifrancheside; D054303:HIV Reverse Transcriptase