title: Systemic bone growth factors in light breed mares and their foals.
abstract: There is a high incidence of bony pathology in race horses. Thus, plasma GH, IGF-1, osteocalcin (OC), calcium (Ca) and inorganic phosphorus (P) concentrations were measured in 12 healthy Selle Français foals and their dams during the first five months after birth. Plasma IGF-1 and OC concentrations were higher in foals than in mares (336 +/- 25 vs 230 +/- 18 ng/ml, P < 0.05; 52.5 +/- 3.2 vs 4.9 +/- 0.1 ng/mg, P < 0.01, respectively). A significant positive linear relationship could be established between these two parameters in foals (IGF-1 = 19 + 0.619 OC; P < 0.05). Another striking evidence was the increase in plasma IGF-1, OC and P concentrations observed during the first week of postnatal life. IGF-1, OC, P and Ca concentrations remained elevated during the experimental period, indicating an intense skeletal growth (confirmed by growth curve) in these animals.
authors.affiliation: INRA Clermont-Theix, Saint-Genès-Champanelle, France.
authors.forename: M J
authors.initials: MJ
authors.lastname: Davicco
authors.forename: Y
authors.initials: Y
authors.lastname: Faulconnier
authors.forename: V
authors.initials: V
authors.lastname: Coxam
authors.forename: H
authors.initials: H
authors.lastname: Dubroeucq
authors.forename: W
authors.initials: W
authors.lastname: Martin-Rosset
authors.forename: J P
authors.initials: JP
authors.lastname: Barlet
mesh_terms: D000375:Aging; D000818:Animals; D001846:Bone Development; D002118:Calcium / Q000097:blood; D005260:Female; D013006:Growth Hormone / Q000097:blood; D006736:Horses / Q000097:blood*; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D007743:Labor, Obstetric; D015675:Osteocalcin / Q000097:blood; D010758:Phosphorus / Q000097:blood; D011247:Pregnancy
chemical_list: D015675:Osteocalcin; D010758:Phosphorus; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D002118:Calcium