Clinical and biologic characteristics of CD7+ acute myeloid leukemia. Our experience and literature review.
Six patients with acute myeloid leukemia (AML) expressing CD7 antigen (CD7+ AML) were studied. They consisted of five patients with M1 and one with an M2 morphology. Two cases expressed other lymphoid-associated antigens, in addition to CD7. The complete remission rate was 50%. One patient had central nervous system recurrence. Cytogenetic analysis demonstrated normal karyotypes in all the cases. All but one had germline configurations of the T-cell receptor (TCR) genes and immunoglobulin heavy chain gene. However, all did not have detectable recombinase activating gene-1 activity by the RT-PCR technique. We performed colony formation assay in two patients, and no enhancement of colony formation by granulocyte colony-stimulating factor was noted. The results presented here, together with those reported previously, suggest that CD7+ AML may demonstrate lineage infidelity.
Shimamoto
T
T
First Department of Internal Medicine, Tokyo Medical College, Japan.
Ohyashiki
J H
JH
Ohyashiki
K
K
Kawakubo
K
K
Inatomi
Y
Y
Fujieda
H
H
Nakazawa
S
S
Kimura
N
N
Miyauchi
J
J
Toyama
K
K
D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D001483:Base Sequence; D002648:Child; D017931:DNA Primers; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D018398:Homeodomain Proteins; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007133:Immunoglobulin Joining Region / Q000235:genetics; D016130:Immunophenotyping; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D014407:Tumor Cells, Cultured
D015703:Antigens, CD; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte; D017931:DNA Primers; D018398:Homeodomain Proteins; D007143:Immunoglobulin Heavy Chains; D007133:Immunoglobulin Joining Region; D011948:Receptors, Antigen, T-Cell; C064658:RAG-1 protein; D016179:Granulocyte Colony-Stimulating Factor