title: The role of ultrasound in prostate cancer detection in patients with an elevated prostate specific antigen level but no prostatic nodule.
abstract: An increased level of prostate specific antigen (PSA) in the blood is a relatively sensitive indicator of prostate disease; a significant minority of men with increased PSA will have prostate carcinoma. A total of 736 men with a PSA elevation of greater than 4.2 without a rectally palpable prostate mass were evaluated with transrectal ultrasound at the Ultrasound Institute of Baltimore over a three-year period. Transrectal biopsy under ultrasound control was performed when a localized mass was seen on ultrasound or the prostate was small and the PSA level significantly elevated (93% of the series underwent biopsy). There was a positive biopsy yield for cancer of 38.5% in the cases biopsied. This high positive yield was achieved by combining high quality ultrasound with two to three samples from a visible mass and random samples from other sites.
authors.affiliation: Ultrasound Institute of Baltimore.
authors.forename: R C
authors.initials: RC
authors.lastname: Sanders
mesh_terms: D000328:Adult; D000368:Aged; D006801:Humans; D008297:Male; D008875:Middle Aged; D010173:Palpation; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology; D012680:Sensitivity and Specificity; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen