title: [Pathological basis for elevation of serum prostate specific antigen].
abstract: 67 patients with serum prostate specific antigen (PSA) over 4ng/ml were investigated pathologically. All the patients had prostatic lesions: prostate cancer (24) and benign prostatic lesions (43). The serum PSA was conspicuously higher in the carcinoma group than in the benign group (P < 0.01). When 10ng/ml was used as the low limit to detect prostate cancer, the sensitivity and specificity were 83.3% and 74.4% respectively. We suggest that the range of serum PSA from 4.0 to 10.0ng/ml should be considered dangerous in detecting prostate cancer. The epithelium-blood barrier lesion and epithelial hyperplasia of the prostate might be the pathological basis for the elevation of serum PSA.
authors.affiliation: Institute of Urology, Beijing Medical University.
authors.forename: T L
authors.initials: TL
authors.lastname: Xia
authors.forename: F M
authors.initials: FM
authors.lastname: Deng
authors.forename: T
authors.initials: T
authors.lastname: Feng
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003937:Diagnosis, Differential; D006801:Humans; D006965:Hyperplasia; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000276:immunology*; D011471:Prostatic Neoplasms / Q000276:immunology* / Q000473:pathology; D012680:Sensitivity and Specificity
chemical_list: D017430:Prostate-Specific Antigen