The mniopetals, new inhibitors of reverse transcriptases from a Mniopetalum species (Basidiomycetes). I. Producing organism, fermentation, isolation and biological activities.
Six novel enzyme inhibitors of RNA-directed DNA-polymerases of human immunodeficiency-, avian myeloblastosis and murine leukemia viruses were isolated from fermentations of a canadian Mniopetalum species. They were named mniopetals A, B, C, D, E and F. Their structures were elucidated by spectroscopic methods. The compounds, in addition to their inhibitory activities on reverse transcriptases, exhibit antimicrobial and cytotoxic properties.
Kuschel
A
A
LB Biotechnology, The University, Kaiserslautern, FRG.
Anke
T
T
Velten
R
R
Klostermeyer
D
D
Steglich
W
W
König
B
B
D000935:Antifungal Agents / Q000096:biosynthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000302:isolation & purification / Q000494:pharmacology*; D009189:Avian Myeloblastosis Virus / Q000201:enzymology; D001487:Basidiomycota / Q000737:chemistry* / Q000378:metabolism*; D005285:Fermentation; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000201:enzymology; D008979:Moloney murine leukemia virus / Q000201:enzymology; D018894:Reverse Transcriptase Inhibitors; D014764:Viral Proteins / Q000037:antagonists & inhibitors
D000935:Antifungal Agents; D000998:Antiviral Agents; D018894:Reverse Transcriptase Inhibitors; D014764:Viral Proteins; D054303:HIV Reverse Transcriptase