Modulation of associative memory function in a biophysical simulation of rat piriform cortex.
1. Associative memory function was analyzed in a realistic biophysical simulation of rat piriform (olfactory) cortex containing 240 pyramidal cells and 58 each of two types of inhibitory interneurons. Pyramidal cell simulations incorporated six different intrinsic currents and three different synaptic currents. We investigated the hypothesis that acetylcholine sets the appropriate dynamics for learning within the network, whereas removal of cholinergic modulation sets the appropriate dynamics for recall. The associative memory function of the network was tested during recall after simulation of the cholinergic suppression of intrinsic fiber synaptic transmission and the cholinergic suppression of neuronal adaptation during learning. 2. Hebbian modification of excitatory synaptic connections between pyramidal cells during learning of patterns of afferent activity allowed the model to show the basic associative memory property of completion during recall in response to degraded versions of those patterns, as evaluated by a performance measure based on normalized dot products. 3. During learning of multiple overlapping patterns of afferent activity, recall of previously learned patterns interfered with the learning of new patterns. As more patterns were stored this interference could lead to the exponential growth of a large number of excitatory synaptic connections within the network. This runaway synaptic modification during learning led to excessive excitatory activity during recall, preventing the accurate recall of individual patterns. 4. Runaway synaptic modification of excitatory intrinsic connections could be prevented by selective suppression of synaptic transmission at these synapses during learning. This allowed effective recall of single learned afferent patterns in response to degraded versions of those patterns, without interference from other learned patterns. 5. During learning, cholinergic suppression of neuronal adaptation enhanced the activity of cortical pyramidal cells in response to afferent input, compensating for decreased activity due to suppression of intrinsic fiber synaptic transmission. This modulation of adaptation led to more rapid learning of afferent input patterns, as demonstrated by higher values of the performance measure. 6. During recall, when suppression of excitatory intrinsic synaptic transmission was removed, continued cholinergic suppression of neuronal adaptation led to the spread of excessive activity. More stable activity patterns during recall could be obtained when the cholinergic suppression of neuronal adaptation was removed at the same time as the cholinergic suppression of synaptic transmission. 7. A realistic biophysical simulation of the effects of acetylcholine on synaptic transmission and neuronal adaptation in the piriform cortex shows that these effects act together to set the appropriate dynamics for learning, whereas removal of both effects sets the appropriate dynamics for recall.
Barkai
E
E
Department of Psychology, Harvard University, Cambridge, Massachusetts 02138.
Bergman
R E
RE
Horwitz
G
G
Hasselmo
M E
ME
D000109:Acetylcholine / Q000502:physiology; D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001245:Association Learning / Q000502:physiology*; D002540:Cerebral Cortex / Q000502:physiology*; D002799:Cholinergic Fibers / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D007395:Interneurons / Q000502:physiology; D007473:Ion Channels / Q000502:physiology; D011939:Mental Recall / Q000502:physiology*; D009433:Neural Inhibition / Q000502:physiology; D016571:Neural Networks, Computer; D009833:Olfactory Pathways / Q000502:physiology*; D051381:Rats; D012984:Software; D009435:Synaptic Transmission / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D007473:Ion Channels; D005680:gamma-Aminobutyric Acid; D000109:Acetylcholine