title: Sciatic axotomy compromises axonal transport of transganglionic tracer BSI-B4 from the soma to the central terminals of C fibre afferents.
abstract: The C afferent specific lectin BSI-B4 was used to examine the effects of sciatic axotomy on axonal transport by the C afferent subpopulation. From about 4 days after sciatic nerve lesion, BSI-B4 injected into the peripheral nerve is transported only as far as the neuronal cell bodies in the dorsal root ganglion. The previous demonstrations of A beta afferent terminal sprouting into lamina II, and the atrophy of lamina II terminals, in response to sciatic lesions may be related to the inability of C afferents to maintain transganglionic transport.
authors.affiliation: Department of Anatomical Sciences, University of Queensland, St. Lucia, Australia.
authors.forename: P D
authors.initials: PD
authors.lastname: Kitchener
authors.forename: P
authors.initials: P
authors.lastname: Wilson
authors.forename: P J
authors.initials: PJ
authors.lastname: Snow
mesh_terms: D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D001369:Axons / Q000502:physiology*; D005260:Female; D005727:Ganglia, Spinal / Q000166:cytology / Q000378:metabolism*; D006651:Histocytochemistry; D037102:Lectins; D009410:Nerve Degeneration / Q000502:physiology; D009412:Nerve Fibers / Q000378:metabolism*; D009475:Neurons, Afferent / Q000378:metabolism*; D037121:Plant Lectins; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000502:physiology*
chemical_list: C045475:Griffonia simplicifolia lectins; D037102:Lectins; D037121:Plant Lectins