title: Dideoxy sequencing and structural analysis of the rat insulin-like growth factor binding protein-1 gene.
abstract: Insulin-like growth factor binding protein-1 (IGFBP-1) is an important modulator of IGF bioavailability. To facilitate studies of IGFBP-1 regulation and function in rodent models, we cloned the rat IGFBP-1 gene and analyzed its structure by dideoxy sequencing. The rat IGFBP-1 gene is relatively small (approximately 5 kb) and contains 4 exons and 3 introns, similar to the human IGFBP-1 gene.
authors.affiliation: Department of Medicine, University of Illinois College of Medicine, Chicago.
authors.forename: R
authors.initials: R
authors.lastname: Lacson
authors.forename: D
authors.initials: D
authors.lastname: Oehler
authors.forename: E
authors.initials: E
authors.lastname: Yang
authors.forename: R
authors.initials: R
authors.lastname: Goswami
authors.forename: T
authors.initials: T
authors.lastname: Unterman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I; D008969:Molecular Sequence Data; D051381:Rats
chemical_list: D002352:Carrier Proteins; D018076:DNA, Complementary; D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I