title: Vascular biology: relevance of nitric oxide in vascular and nonvascular tissue with normal and decreased renal function.
abstract: Nitric oxide has been recognized as an important paracrine or autocrine system during the past decade. The generalized importance of this rather simple molecule has been demonstrated in of a variety of neural, epithelial, vascular and immune systems. The degree to which alterations in nitric oxide metabolism contribute to the physiologic and pathophysiologic status of patients with end-stage renal disease remains to be fully defined in both experimental animals and in humans afflicted with renal disease.
authors.affiliation: Department of Medicine, University of California, San Diego School of Medicine 92161.
authors.forename: R C
authors.initials: RC
authors.lastname: Blantz
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000378:metabolism; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D004730:Endothelium, Vascular / Q000502:physiology* / Q000503:physiopathology; D004790:Enzyme Induction; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000503:physiopathology / Q000517:prevention & control; D007249:Inflammation / Q000503:physiopathology; D007674:Kidney Diseases / Q000503:physiopathology*; D009569:Nitric Oxide / Q000502:physiology*; D019001:Nitric Oxide Synthase; D012772:Shock, Septic / Q000503:physiopathology; D019323:omega-N-Methylarginine
chemical_list: D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases