The effect of graded ascorbic acid intake on the activity of GSH-Px in the liver of female guinea pigs.
Differing antioxidant potentials created by graded ascorbic acid supplementation (1, 10, 100 mg per animal daily) evoked changes in the level of glutathione peroxidase activity and lipid peroxides in the liver of female guinea pigs. The group with the lowest ascorbic acid intake (1 mg) had the lowest activity of glutathione peroxidase and the highest level of lipid peroxides. The two other groups (10 and 100 mg) showed enhancement of glutathione peroxidase activity and decline in lipid peroxides. There was no difference between the groups with 10 and 100 mg ascorbic acid intake.
Kováciková
Z
Z
Institute of Clinical and Preventive Medicine, Bratislava, Slovak Republic.
Ginter
E
E
Madaric
A
A
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005979:Glutathione Peroxidase / Q000378:metabolism*; D006168:Guinea Pigs; D015227:Lipid Peroxidation / Q000187:drug effects; D008099:Liver / Q000187:drug effects* / Q000201:enzymology; D008315:Malondialdehyde / Q000378:metabolism
D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D001205:Ascorbic Acid