title: Expression of the large myelin-associated glycoprotein isoform in rat oligodendrocytes around cerebral infarcts.
abstract: An immunohistochemical method that uses two specific antisera-distinguishable myelin-associated glycoprotein (MAG) isoforms showed an expression of large MAG isoform (L-MAG) protein in the oligodendrocyte cytoplasms in the white matter around experimental cerebral infarcts produced by occlusion of the left middle cerebral artery in the rat. L-MAG protein also was detected in the white matter on the contralateral side. This protein appears prior to S-MAG protein in myelination and remyelination in the central and peripheral nervous systems, and is believed to function in myelin formation. Because L-MAG protein has been found in the oligodendrocyte cytoplasm only in the early development period, its appearance in this cytoplasm after ischemic insult is evidence of MAG regeneration.
authors.affiliation: Department of Neurology, Niigata University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ishiguro
authors.forename: T
authors.initials: T
authors.lastname: Inuzuka
authors.forename: N
authors.initials: N
authors.lastname: Fujita
authors.forename: S
authors.initials: S
authors.lastname: Sato
authors.forename: R
authors.initials: R
authors.lastname: Nakano
authors.forename: A
authors.initials: A
authors.lastname: Tamura
authors.forename: T
authors.initials: T
authors.lastname: Kirino
authors.forename: T
authors.initials: T
authors.lastname: Miyatake
mesh_terms: D000818:Animals; D002544:Cerebral Infarction / Q000378:metabolism*; D003593:Cytoplasm / Q000737:chemistry; D007124:Immunoenzyme Techniques; D008297:Male; D008970:Molecular Weight; D009185:Myelin Proteins / Q000032:analysis* / Q000737:chemistry; D018992:Myelin-Associated Glycoprotein; D009836:Oligodendroglia / Q000737:chemistry* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein