The complexity of dopamine receptors and psychopharmacotherapy in children.
The efficacy of dopaminergic antagonists, which are neuroleptics, has been shown in children in varied clinical situations. Five dopaminergic receptors (D1, D2, D3, D4, D5) have thus far been cloned: their existence has thus been confirmed, but their functional significance remains to be determined. This publication reviews their main characteristics. The multiplicity of cerebral dopamine receptors is consistent with the future development of new, more selective and discriminating psychotropic drugs. The diversity of interactions of dopaminergic receptors, among themselves and with receptors for other neurotransmitters, however, explains the difficulty in understanding the mechanism of action of neuroleptics and defining their more rational use in children.
Guérin
P
P
Département de Psychopathologie de l'Enfant et de Neurophysiologie du Développement, INSERM U316-CHU Bretonneau, Tours, France.
Barthélémy
C
C
Garreau
B
B
Héraut
J
J
Muh
J P
JP
Lelord
G
G
D000293:Adolescent; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001665:Binding Sites; D001921:Brain / Q000187:drug effects / Q000378:metabolism / Q000503:physiopathology*; D002450:Cell Communication / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D017362:Cyclic AMP Response Element-Binding Protein / Q000502:physiology; D002658:Developmental Disabilities / Q000378:metabolism / Q000503:physiopathology*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D008297:Male; D011954:Receptors, Dopamine / Q000187:drug effects* / Q000502:physiology
D014150:Antipsychotic Agents; D017362:Cyclic AMP Response Element-Binding Protein; D011954:Receptors, Dopamine; D006160:Guanosine Triphosphate; D004298:Dopamine