title: Efficacy of the hematoregulatory peptide SK&F 107647 in experimental systemic Candida albicans infections in normal and immunosuppressed mice.
abstract: SK&F 107647, a novel synthetic dimeric pentapeptide, has been shown to be a potent hematoregulatory agent. The potential for the hematoregulatory factors elicited by SK&F 107647 to confer protection in experimental models of systemic Candida albicans infection was evaluated in immunosuppressed and immunocompetent mice. Prophylactic treatment with recombinant human interleukin-1 (rhIL-1), recombinant human granulocyte colony stimulating factor (rhG-CSF), or the hematoregulatory peptide SK&F 107647 significantly increased survival times in gamma irradiated immunosuppressed as well as non-irradiated immunocompetent mice challenged with a lethal dose of C. albicans. Protection was also observed in athymic nu/nu "nude" mice. Additionally, significant increases in survival in non-irradiated immunocompetent mice dosed by oral gavage were observed. These results indicate that SK&F 107647 can significantly enhance natural host resistance to experimental C. albicans infections both in immunosuppressed and immunocompetent mice.
authors.affiliation: Department of Anti-Infectives, Smithkline Beecham Pharmaceuticals, King of Prussia, PA 19406.
authors.forename: P L
authors.initials: PL
authors.lastname: DeMarsh
authors.forename: S K
authors.initials: SK
authors.lastname: Sucoloski
authors.forename: C L
authors.initials: CL
authors.lastname: Frey
authors.forename: P K
authors.initials: PK
authors.lastname: Bhatnagar
authors.forename: Y
authors.initials: Y
authors.lastname: Koltin
authors.forename: P
authors.initials: P
authors.lastname: Actor
authors.forename: S R
authors.initials: SR
authors.lastname: Petteway
mesh_terms: D000818:Animals; D002177:Candidiasis / Q000276:immunology / Q000517:prevention & control*; D004195:Disease Models, Animal; D005720:Gamma Rays / Q000009:adverse effects; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007165:Immunosuppression Therapy; D007375:Interleukin-1 / Q000627:therapeutic use; D051379:Mice; D008807:Mice, Inbred BALB C; D008819:Mice, Nude; D009842:Oligopeptides / Q000627:therapeutic use*; D011994:Recombinant Proteins / Q000627:therapeutic use; D015996:Survival Rate
chemical_list: D007375:Interleukin-1; D009842:Oligopeptides; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; C086049:SK&F 107647