title: Hispidospermidin, a novel phospholipase C inhibitor produced by Chaetosphaeronema hispidulum (Cda) Moesz NR 7127. II. Isolation, characterization and structural elucidation.
abstract: Hispidospermidin (1) is a novel phospholipase C inhibitor produced by Chaetosphaeronema hispidulum (Cda) Moesz NR 7127. Its structure (C25H47N3O) has been elucidated as a cage compound with a trimethylspermidine side chain based on various NMR studies, including 1H-1H COSY, 13C-1H COSY, HOHAHA, HMBC, COLOC and long range J C-H resolved 2D spectroscopy. The absolute configuration of 1 has been elucidated by modified Mosher's method on the (R)- and (S)-MTPA amides of a derivative of 1.
authors.affiliation: Nippon Roche Research Center, Kamakura, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ohtsuka
authors.forename: Y
authors.initials: Y
authors.lastname: Itezono
authors.forename: N
authors.initials: N
authors.lastname: Nakayama
authors.forename: A
authors.initials: A
authors.lastname: Sakai
authors.forename: N
authors.initials: N
authors.lastname: Shimma
authors.forename: K
authors.initials: K
authors.lastname: Yokose
authors.forename: H
authors.initials: H
authors.lastname: Seto
mesh_terms: D002597:Chaetomium / Q000378:metabolism*; D011083:Polycyclic Compounds / Q000737:chemistry* / Q000302:isolation & purification*; D013095:Spermidine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification; D013237:Stereoisomerism; D013329:Structure-Activity Relationship; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors*
chemical_list: D011083:Polycyclic Compounds; C086148:hispidospermidin; D010738:Type C Phospholipases; D013095:Spermidine