title: Histopathological study following catheter guided radiofrequency current ablation of the slow pathway in a patient with atrioventricular nodal reentrant tachycardia.
abstract: The present study examined histological changes induced by catheter guided radiofrequency current in a patient with AV nodal reentrant tachycardia who underwent cardiac transplantation 1 week after ablation of the slow pathway. During the electrophysiology study AV nodal conduction curves were discontinuous and AV nodal reentry was induced. At the conclusion of the procedure there was no evidence of slow pathway function. Histological sections from the explanted heart demonstrated a sharply demarcated atrial lesion (5 x 5 x 4 mm) extending from the septal portion of the tricuspid annulus to the posterior border of the AV node. The lesion did not encompass the compact AV node. These observations support the hypothesis that the slow pathway is comprised of atrial approaches to the AV node and is distinct from the compact AV node.
authors.affiliation: Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri 63110.
authors.forename: M C
authors.initials: MC
authors.lastname: Gamache
authors.forename: S
authors.initials: S
authors.lastname: Bharati
authors.forename: M
authors.initials: M
authors.lastname: Lev
authors.forename: B D
authors.initials: BD
authors.lastname: Lindsay
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D001283:Atrioventricular Node / Q000473:pathology* / Q000503:physiopathology; D002036:Bundle of His / Q000503:physiopathology; D005117:Cardiac Complexes, Premature / Q000503:physiopathology; D017115:Catheter Ablation; D003331:Coronary Vessels / Q000473:pathology / Q000503:physiopathology; D004562:Electrocardiography; D005355:Fibrosis; D006325:Heart Atria / Q000473:pathology / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*