Anti-tubulin immunohistochemistry study of Echinococcus granulosus protoscolices incubated with albendazole and albendazole sulphoxide in vitro.
Tubulin content was immunohistochemically studied in Echinococcus granulosus protoscolices incubated with albendazole and albendazole sulphoxide alone or in combination. Tubulin immunoreactivity was very patent in the control protoscolices and was mainly located in the sucker region and the invagination channel of protoscolices. Treated protoscolices always showed less immunoreactivity than did control protoscolices. We concluded that albendazole and its metabolite albendazole sulphoxide produce tubulin alterations in E. granulosus protoscolices.
Pérez-Serrano
J
J
Laboratory of Parasitology, Faculty of Pharmacy, University of Alcalá de Henares, Madrid, Spain.
Denegri
G
G
Casado
N
N
Bodega
G
G
Rodríguez-Caabeiro
F
F
D015766:Albendazole / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D000909:Antibodies, Helminth / Q000276:immunology; D002417:Cattle; D004446:Echinococcus / Q000737:chemistry / Q000187:drug effects* / Q000648:ultrastructure; D007150:Immunohistochemistry; D012756:Sheep / Q000469:parasitology; D014404:Tubulin / Q000032:analysis* / Q000276:immunology
D000909:Antibodies, Helminth; D014404:Tubulin; D015766:Albendazole; C027186:albendazole sulfoxide