Altered angiotensin-II receptors in human hepatocellular and hepatic metastatic colon cancers.
OBJECTIVE
To characterize angiotensin-II receptor density and affinity in normal and cirrhotic livers and in hepatocellular and metastatic colorectal cancer.


BACKGROUND
Several studies have indicated a possible beneficial effect of angiotensin-II as a biologic response modifier in the treatment of hepatic or metastatic colon cancer. This is based on evidence that angiotensin-II will cause a selective increase in arterial vasoconstriction in normal liver compared with tumor.


METHODS
Human hepatoma (5), metastatic colon (10), or cirrhotic (3) liver was obtained. Non-tumor-bearing regions served as normal liver. Angiotensin-II receptor binding was determined on membranes with 125I-angiotensin-II and in situ studies were performed using the biotin-avidin detection system.


RESULTS
Angiotensin-II receptor density was markedly down-regulated in tumor compared with normal or cirrhotic liver.


CONCLUSIONS
A loss of angiotensin-II receptors occurs on the neovasculature of hepatic tumors.
Sitzmann
J V
JV
Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
Wu
Y
Y
Cameron
J L
JL
D000328:Adult; D000368:Aged; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000378:metabolism* / Q000556:secondary*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000556:secondary*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism; D008113:Liver Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000556:secondary*; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism; D051381:Rats; D011945:Receptors, Angiotensin / Q000378:metabolism*
D011945:Receptors, Angiotensin