title: Establishment and validation of a dose-effect curve for gamma-rays by cytogenetic analysis.
abstract: A dose-effect curve obtained by analysis of dicentric chromosomes after irradiation of peripheral blood samples, from one donor, at 11 different doses of gamma-rays is presented. For the elaboration of this curve, more than 18,000 first division metaphases have been analyzed. The results fit very well to the linear-quadratic model. To validate the curve, samples from six individuals (three controls and three occupationally exposed persons) were irradiated at 2 Gy. The results obtained, when compared with the curve, showed that in all cases the 95% confidence interval included the 2 Gy dose, with estimated dose ranges from 1.82 to 2.19 Gy.
authors.affiliation: Departament de Biologia Animal, Biologia Vegetal i Ecologia, Facultat de Ciències, Universitat Autònoma de Barcelona, Spain.
authors.forename: J F
authors.initials: JF
authors.lastname: Barquinero
authors.forename: L
authors.initials: L
authors.lastname: Barrios
authors.forename: M R
authors.initials: MR
authors.lastname: Caballín
authors.forename: R
authors.initials: R
authors.lastname: Miró
authors.forename: M
authors.initials: M
authors.lastname: Ribas
authors.forename: A
authors.initials: A
authors.lastname: Subias
authors.forename: J
authors.initials: J
authors.lastname: Egozcue
mesh_terms: D001769:Blood / Q000528:radiation effects; D002877:Chromosomes, Human / Q000528:radiation effects; D005720:Gamma Rays; D006801:Humans; D066298:In Vitro Techniques; D011829:Radiation Dosage