alpha-Fetoprotein producing gastric carcinomas: a comparative study of three different subtypes.
Nine cases of gastric carcinoma with excessive production of alpha-fetoprotein (AFP) were analyzed morphologically, histochemically and biochemically. Consequently, it was proposed that AFP-producing gastric carcinomas should be divided into three subtypes: (i) hepatoid type; (ii) yolk sac tumor-like type; and (iii) fetal gastrointestinal type. The data from the study suggested that the hepatoid type and the yolk sac tumor-like type are derived from liver cell metaplasia and yolk sac cell metaplasia of common poorly differentiated medullary adenocarcinoma, respectively. The fetal gastrointestinal type seemed to be a result of the imitation of fetal gastrointestinal epithelium by common tubular adenocarcinoma. The hepatoid type was also the most common in the file of AFP-producing gastric carcinoma. Unfortunately, most of the hepatoid types seemed to be highly malignant.
Motoyama
T
T
Department of Pathology, Niigata University School of Medicine, Japan.
Aizawa
K
K
Watanabe
H
H
Fukase
M
M
Saito
K
K
D000368:Aged; D000369:Aged, 80 and over; D003208:Concanavalin A / Q000378:metabolism; D005260:Female; D006651:Histocytochemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D037102:Lectins; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011485:Protein Binding; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000648:ultrastructure; D000509:alpha-Fetoproteins / Q000096:biosynthesis* / Q000378:metabolism
D037102:Lectins; D000509:alpha-Fetoproteins; D003208:Concanavalin A