title: The extrapyramidal effects of phenothiazines on patients.
abstract: The phenothiazines have been used for many years in the treatment of psychoses. They act by blocking dopamine receptors. Unfortunately, they can also produce extrapyramidal side-effects (EPS). The pharmacological origins of these side-effects are explored in this paper and their presentation, prevalence and reversibility are considered. Non-motor adverse effects are also described, and implications for patient monitoring and education are also noted.
authors.forename: J
authors.initials: J
authors.lastname: Sims
mesh_terms: D014150:Antipsychotic Agents / Q000009:adverse effects*; D004298:Dopamine / Q000378:metabolism; D065127:Dopamine D2 Receptor Antagonists; D004409:Dyskinesia, Drug-Induced / Q000209:etiology; D006801:Humans; D010640:Phenothiazines / Q000009:adverse effects*; D017448:Receptors, Dopamine D2 / Q000502:physiology
chemical_list: D014150:Antipsychotic Agents; D065127:Dopamine D2 Receptor Antagonists; D010640:Phenothiazines; D017448:Receptors, Dopamine D2; D004298:Dopamine