[Nasal polyps and substance P: a preliminary report].
Nasal-sinusal polyposis is a disease with a multifactorial pathogenesis that is often indicative of focal hyperactivity. In the human nasal mucosa are present trigeminal nervous fibres which release Substance P and other neuropeptides in reply to multiple stimuli. Employing immunohistochemical methods the Authors studied the presence and the distribution of SP in tissue biopsies made during surgery in 18 patients with a non-allergic nasal polyposis. In 8 cases, including all those subjects with recurrences, an immunohistochemical positivity towards SP was noticed. The Authors suggest possible involvement of SP in the pathogenesis of some forms of nasal polyposis.
Beatrice
F
F
I Cattedra di Clinica Otorinolaringoiatrica, Università di Torino.
Aluffi
P
P
Bottomicca
F
F
Perlasco
L
L
Sartoris
A
A
D000911:Antibodies, Monoclonal / Q000276:immunology; D006801:Humans; D009298:Nasal Polyps / Q000276:immunology / Q000503:physiopathology*; D013373:Substance P / Q000276:immunology / Q000502:physiology*
D000911:Antibodies, Monoclonal; D013373:Substance P