title: Correction of neutropenia with rHuG-CSF after loss of response to rHuGM-CSF following autologous bone marrow transplant.
abstract: We describe a patient who presented with graft failure following autologous BMT, with an initial response of the neutrophil count to rHuGM-CSF but eventual loss of this response. Subsequently, this patient responded to rHuG-CSF. This could be explained by the fact that rHuG-CSF stimulates both early and late myeloid progenitor cells whereas rHuGM-CSF stimulates mainly the intermediate myeloid progenitor cells. This finding suggests that rHuG-CSF should be investigated for the treatment of patients with graft failure following ABMT.
authors.affiliation: Department of Pediatrics, Memorial Sloan-Kettering Cancer Center, New York, New York 10021.
authors.forename: F
authors.initials: F
authors.lastname: Boulad
authors.forename: A
authors.initials: A
authors.lastname: Gillio
authors.forename: T N
authors.initials: TN
authors.lastname: Small
authors.forename: M A
authors.initials: MA
authors.lastname: Bonilla
authors.forename: P
authors.initials: P
authors.lastname: Philips
authors.forename: M
authors.initials: M
authors.lastname: Ruggiero
authors.forename: D
authors.initials: D
authors.lastname: Emanuel
authors.forename: F
authors.initials: F
authors.lastname: Ghavimi
authors.forename: N A
authors.initials: NA
authors.lastname: Kernan
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D009503:Neutropenia / Q000628:therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use; D014182:Transplantation, Autologous
chemical_list: D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor