title: P-glycoprotein expression as unfavorable prognostic factor in acute myeloid leukemia.
abstract: In order to further define the role of the MDR1 gene in acute myeloid leukemia (AML), we determined the association between the presence of P-glycoprotein on leukemic cells and the efficacy of therapy in patients with AML. Immunocytochemistry with monoclonal antibody C219 was performed to demonstrate the presence of P-glycoprotein. Positive staining ranged from 0 to 60% of the leukemic cells. For further analysis, patients were assigned into groups with 0-5% staining cells (group 1, n = 33) and with > 5% staining cells (group 2, n = 19). The complete remission rate of induction chemotherapy was 76% for group 1 but only 32% for group 2 (p = 0.002). The median duration of overall survival was 19 months for patients in group 1 as compared to 3 months for patients in group 2 (p = 0.007). The data indicate that P-glycoprotein expression is associated with an unfavorable prognosis in patients with AML.
authors.affiliation: Clinic for Internal Medicine I, University of Vienna Medical School, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Zöchbauer
authors.forename: A
authors.initials: A
authors.lastname: Gsur
authors.forename: R
authors.initials: R
authors.lastname: Brunner
authors.forename: P A
authors.initials: PA
authors.lastname: Kyrle
authors.forename: K
authors.initials: K
authors.lastname: Lechner
authors.forename: R
authors.initials: R
authors.lastname: Pirker
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000911:Antibodies, Monoclonal; D002352:Carrier Proteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D004351:Drug Resistance; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007951:Leukemia, Myeloid / Q000235:genetics / Q000503:physiopathology*; D008297:Male; D008562:Membrane Glycoproteins / Q000032:analysis / Q000235:genetics / Q000502:physiology*; D008875:Middle Aged; D011379:Prognosis; D012313:RNA / Q000235:genetics
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000911:Antibodies, Monoclonal; D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D012313:RNA