[The resistance of activated partial thromboplastin time to heparin infusion during hemodialysis].
Activated partial thromboplastin time (aPTT) during heparin infusion in 10 patients on regular dialytic treatment was evaluated. At end-dialysis (3 hours) plasma heparinization ranged between 2000-4000 IU and from the clinical point of view dialytic performance was good. At end-dialysis aPTT was 53 +/- 14 seconds: this value is under the prescribed aPTT prolongation (1.5-2 times baseline values) to achieve a therapeutic heparin plasma level. Physiopathological implications of this aPTT "resistance" to heparin infusion are studied.
Camici
M
M
Istituto di Clinica Medica II, Ospedale S. Chiara, Università degli Studi, Pisa.
Sagripanti
A
A
Barsotti
G
G
Baicchi
U
U
Evangelisti
L
L
Morelli
E
E
Giovannetti
S
S
D000328:Adult; D000368:Aged; D000990:Antithrombin III / Q000032:analysis; D005340:Fibrinogen / Q000032:analysis; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D008875:Middle Aged; D010314:Partial Thromboplastin Time; D011516:Prothrombin / Q000032:analysis; D006435:Renal Dialysis; D013925:Thromboplastin / Q000187:drug effects*
D000990:Antithrombin III; D011516:Prothrombin; D005340:Fibrinogen; D006493:Heparin; D013925:Thromboplastin