title: Effects of adenosine on chronotropic responses of rat atria to alpha and beta adrenergic stimulation.
abstract: The chronotropic response of rat atria to beta adrenergic stimulation required higher concentrations of agonist in the presence of adenosine. This anti beta-adrenergic effect could attenuate the tachycardia induced by the increased sympathetic tone during cardiac ischemia. The sensitivity to alpha adrenergic stimulation did not change in the presence of adenosine.
authors.affiliation: Centro de Investigationes Cardiovasculares, Facultad de Ciencias Medicas, Universidad Nacional de La Plata, Argentina.
authors.forename: O A
authors.initials: OA
authors.lastname: Gende
mesh_terms: D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D010656:Phenylephrine / Q000494:pharmacology*; D011224:Prazosin / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010656:Phenylephrine; D000241:Adenosine; D011224:Prazosin