The effect of aluminum chloride on some steps of heme biosynthesis in rats after oral exposure.
Certain disturbances in heme biosynthesis induced by aluminum chloride were examined. The experiment was performed on female rats that received AlCl3 orally at the dose 100 mg Al/kg daily for 21 d. The effects of aluminum on the activity of delta-aminolevulinic acid synthetase (ALA-S), dehydratase (ALA-D), and heme oxygenase (O.H.) were observed on 3, 7, 14, and 21 d in liver and kidneys of rats. Also the activity of ALA-D in blood and the concentration of delta-aminolevulinic acid (ALA-U) in urine were observed. Orally administered aluminum caused increase in the activity of ALA-D in the liver and blood, and parallel decrease of ALA-U in urine (r = -0.85) of rats. Aluminum chloride also induced an increase of ALA-S and O.H. in the liver but not in the kidneys. The changes of the enzymes activity participating in heme biosynthesis after administration of aluminum may be correlated with anemia and iron metabolism in rats.
Chmielnicka
J
J
Medical University of Lodz, School of Pharmacy, Department of Toxicological Chemistry, Poland.
Nasiadek
M
M
Lewandowska-Zyndul
E
E
D000624:5-Aminolevulinate Synthetase / Q000378:metabolism*; D000284:Administration, Oral; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000008:administration & dosage / Q000633:toxicity*; D000622:Aminolevulinic Acid / Q000097:blood / Q000652:urine; D000818:Animals; D002712:Chlorides / Q000008:administration & dosage / Q000633:toxicity*; D005260:Female; D006400:Hematocrit; D006418:Heme / Q000096:biosynthesis*; D006419:Heme Oxygenase (Decyclizing) / Q000378:metabolism*; D007668:Kidney / Q000187:drug effects / Q000201:enzymology; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D000623:Porphobilinogen Synthase / Q000097:blood* / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride; D006418:Heme; D000622:Aminolevulinic Acid; D006419:Heme Oxygenase (Decyclizing); D000624:5-Aminolevulinate Synthetase; D000623:Porphobilinogen Synthase