[Extracorporeal immunostimulating effect of terrilytin and lysozyme in vibration injury].
In injection of allogeneic erythrocytes treated with terrilytin of lysozyme (LTE) the most marked effect was produced by LTE injection in vibration-exposed rats (VER). When the VER were given injections of various fractions (light, moderate, and heavy) of erythrocytes previously incubated with enzymes, the heavy LTE possessed a marked immunostimulating effect. However, the heavy erythrocyte fraction proved to cause a stronger effect when it was treated successively with terrilytin and lysozyme. It was established that injection of this fraction does not influence the production of immunosuppression factors, in VER, which are produced by splenic cells adhering to the plastic after the vibration action, but induced the production of the immunostimulating factor by VER cells which do not adhere to the plastic.
Prokopenko
L G
LG
Siplivaia
L E
LE
Chalyĭ
G A
GA
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000681:Amylases / Q000627:therapeutic use*; D000818:Animals; D004338:Drug Combinations; D009113:Muramidase / Q000627:therapeutic use*; D010447:Peptide Hydrolases / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014732:Vibration / Q000009:adverse effects*
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D009113:Muramidase; D010447:Peptide Hydrolases