title: Induction of specific-locus and dominant lethal mutations in male mice by trophosphamide.
abstract: Trophosphamide induced dominant lethal and specific-locus mutations in spermatozoa and spermatids of mice. The induction pattern of specific-locus and dominant lethal mutations shows two maxima in the mating intervals 1-4 and 9-16 days post treatment. The nature of induced mutations is suggested to be intergenic.
authors.affiliation: GSF-Forschungszentrum für Umwelt und Gesundheit, GmbH, Institut für Säugetiergenetik, Neuherberg, Oberschleissheim, Germany.
authors.forename: U H
authors.initials: UH
authors.lastname: Ehling
authors.forename: A
authors.initials: A
authors.lastname: Neuhäuser-Klaus
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D013087:Spermatids / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects
chemical_list: D000970:Antineoplastic Agents; D009153:Mutagens; D003520:Cyclophosphamide; C003726:trofosfamide