Fetal marrow suppression after maternal chemotherapy for leukaemia.
A preterm baby, whose mother received chemotherapy for acute leukaemia during pregnancy, required intensive care because of profound anaemia and neutropenia. Haemopoietic progenitor cell studies showed fetal marrow suppression. Those caring for such mothers and babies should know the possible serious effects chemotherapy for malignancies can have on a developing fetus. Long term follow up of the baby is imperative.
Murray
N A
NA
Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Acolet
D
D
Deane
M
M
Price
J
J
Roberts
I A
IA
D000208:Acute Disease; D000328:Adult; D000740:Anemia / Q000139:chemically induced* / Q000628:therapy; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D004921:Erythropoietin / Q000627:therapeutic use; D005047:Etoposide / Q000009:adverse effects; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007231:Infant, Newborn; D007235:Infant, Premature, Diseases / Q000139:chemically induced* / Q000628:therapy; D007951:Leukemia, Myeloid / Q000188:drug therapy*; D009503:Neutropenia / Q000139:chemically induced* / Q000628:therapy; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000188:drug therapy*; D011297:Prenatal Exposure Delayed Effects
D004921:Erythropoietin; D016179:Granulocyte Colony-Stimulating Factor; D005047:Etoposide