title: Does transcription by RNA polymerase play a direct role in the initiation of replication?
abstract: RNA polymerases have been implicated in the initiation of replication in bacteria. The conflicting evidence for a role in initiation in eukaryotes is reviewed.
authors.affiliation: CRC Nuclear Structure and Function Research Group, Sir William Dunn School of Pathology, University of Oxford, UK.
authors.forename: A B
authors.initials: AB
authors.lastname: Hassan
authors.forename: P R
authors.initials: PR
authors.lastname: Cook
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000235:genetics; D019915:DNA Primase; D004261:DNA Replication; D012321:DNA-Directed RNA Polymerases / Q000502:physiology*; D004330:Drosophila / Q000196:embryology; D005057:Eukaryotic Cells / Q000502:physiology*; D008957:Models, Genetic; D011387:Prokaryotic Cells / Q000502:physiology*; D012313:RNA / Q000502:physiology; D012316:RNA Nucleotidyltransferases / Q000502:physiology; D014157:Transcription Factors / Q000502:physiology; D014158:Transcription, Genetic; D014981:Xenopus / Q000196:embryology
chemical_list: C034477:RNA primers; D014157:Transcription Factors; D012313:RNA; D019915:DNA Primase; D012316:RNA Nucleotidyltransferases; D012321:DNA-Directed RNA Polymerases