title: Effect of platelet activating factor (PAF) on the formation of blood vessels in subcutaneous implants in mice.
abstract: Angiogenesis accompanies inflammatory processes and many other pathological conditions. We have studied the effect of platelet-activating factor (PAF) a well-known inflammatory mediator, as a promoter of angiogenesis in the sponge implant model in mice. Development of blood vessels and blood flow were monitored by use of a 133Xe washout technique. The results showed PAF to have angiogenic activity, which was inhibited by WEB 2086, and the PAF-induced vasculature to have normal pharmacological reactivity.
authors.affiliation: Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
authors.forename: S P
authors.initials: SP
authors.lastname: Andrade
authors.forename: L B
authors.initials: LB
authors.lastname: Vieira
authors.forename: Y S
authors.initials: YS
authors.lastname: Bakhle
authors.forename: P J
authors.initials: PJ
authors.lastname: Piper
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D016232:Endothelins / Q000494:pharmacology; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic; D010972:Platelet Activating Factor / Q000494:pharmacology*; D019736:Prostheses and Implants; D014980:Xenon Radioisotopes
chemical_list: D016232:Endothelins; D010972:Platelet Activating Factor; D014980:Xenon Radioisotopes; D000804:Angiotensin II