A comparison of nimesulide and diclofenac in the treatment of acute superficial thrombophlebitis.
In a double-blind study, the efficacy and tolerability of nimesulide (100mg twice daily) were compared with those of diclofenac (50mg twice daily) when administered orally to 50 patients with acute superficial thrombophlebitis of the lower limbs. Pain relief and amelioration of inflammation were apparent in patients treated with either nimesulide or diclofenac; however, gastric intolerance was noted more frequently in those receiving diclofenac. The results of this study suggest that nimesulide should be considered as an alternative to diclofenac and other first-line NSAIDs in the treatment of acute superficial thrombophlebitis.
Ferrari
E
E
Cattedra di Chirurgia Vascolare, Università di Firenze, Italy.
Pratesi
C
C
Scaricabarozzi
I
I
D000208:Acute Disease; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004008:Diclofenac / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D013449:Sulfonamides / Q000627:therapeutic use*; D013924:Thrombophlebitis / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D004008:Diclofenac; C012655:nimesulide