Synthesis of 4-alkoxyaryl beta-D-glucopyranosides and their inhibitory effects on histamine release from rat peritoneal mast cells induced by concanavalin A.
The inhibitory effects of newly synthesized 4-alkoxyaryl beta-D-glucopyranosides on histamine release from rat peritoneal mast cells induced by concanavalin A were examined. A plot of hydrophobicity (k') against inhibitory activity of the compounds showed a distinct maximum, and 4-decyloxy-2,3,6-trimethylphenyl beta-D-glucopyranoside was the most potent inhibitor among the tested compounds.
Wang
T C
TC
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Furukawa
H
H
Nihro
Y
Y
Kakegawa
H
H
Matsumoto
H
H
Satoh
T
T
D000818:Animals; D003208:Concanavalin A / Q000037:antagonists & inhibitors / Q000494:pharmacology; D005960:Glucosides / Q000138:chemical synthesis* / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D010529:Peritoneal Cavity / Q000166:cytology; D051381:Rats; D017207:Rats, Sprague-Dawley
D005960:Glucosides; D003208:Concanavalin A