title: Early life-stage effects in medaka (Oryzias latipes) following in ovo exposure to polyamine biosynthetic inhibitors.
abstract: Medaka, Oryzias latipes, were exposed in ovo to the polyamine (PA) biosynthesis inhibitors alpha-difluoromethylornithine (DFMO) and methylglyoxal bis(guanylhydrazone) (MGBG). In an additional group, spermine, the end product of the PA pathway, was added with DFMO and MGBG for a "rescue" treatment. At 4 days posthatch, length, DNA and RNA content, and swimming endurance were measured. The only parameter affected by treatment was swimming endurance which revealed decreased latent time to fatigue with increased dose, although not statistically significant. The rescue group, however, did demonstrate a statistically significant decrease in fatigue latency as compared to controls.
authors.affiliation: Department of Pharmacology, School of Pharmacy, University of Mississippi, University 38677.
authors.forename: L S
authors.initials: LS
authors.lastname: Ortego
authors.forename: A C
authors.initials: AC
authors.lastname: Nimrod
authors.forename: W T
authors.initials: WT
authors.lastname: Brehm
authors.forename: G R
authors.initials: GR
authors.lastname: Parsons
authors.forename: W H
authors.initials: WH
authors.lastname: Benson
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004247:DNA / Q000032:analysis; D000518:Eflornithine / Q000494:pharmacology*; D008935:Mitoguazone / Q000494:pharmacology*; D009990:Oryzias; D010063:Ovum / Q000187:drug effects / Q000254:growth & development*; D010807:Physical Endurance / Q000187:drug effects; D012313:RNA / Q000032:analysis; D013997:Time Factors
chemical_list: D012313:RNA; D004247:DNA; D008935:Mitoguazone; D000518:Eflornithine