title: Expression of 25(OH) vitamin D3 24-hydroxylase gene in glial cells.
abstract: The expression of the 25(OH) vitamin D3 24-hydroxylase gene was studied in C6 glioma and rat primary glial cell culture. The expression of the 25(OH)D3 24-hydroxylase gene was not detected in C6 glioma or glial cells cultured in a serum-free medium. However, the 25(OH)D3 24-hydroxylase mRNA was induced in a dose-dependent manner in cells treated with 1,25(OH)2D3. These findings provide further evidence for an involvement of vitamin D3 metabolites in brain function.
authors.affiliation: INSERUM U 298 CHU Angers, France.
authors.forename: P
authors.initials: P
authors.lastname: Naveilhan
authors.forename: I
authors.initials: I
authors.lastname: Neveu
authors.forename: C
authors.initials: C
authors.lastname: Baudet
authors.forename: K Y
authors.initials: KY
authors.lastname: Ohyama
authors.forename: P
authors.initials: P
authors.lastname: Brachet
authors.forename: D
authors.initials: D
authors.lastname: Wion
mesh_terms: D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D015152:Blotting, Northern; D002117:Calcitriol / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D005910:Glioma / Q000201:enzymology; D006801:Humans; D009457:Neuroglia / Q000201:enzymology*; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D014407:Tumor Cells, Cultured
chemical_list: D012313:RNA; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase; D002117:Calcitriol