Effect of tenoxicam and indomethacin on the chemotaxis induced by substance P and interleukin-8 on human monocytes and polymorphonuclear cells.
The neuropeptide substance P and the cytokine interleukin-8 are potent chemotactic factors for monocytes and/or polymorphonuclear cells. They are present in the synovial fluid of arthritic patients, and participate in the pathogenesis of arthritis. We investigated in vitro the effect of two non-steroidal antiinflammatory drugs, tenoxicam and indomethacin, on the chemotactic effect of substance P and interleukin-8 at concentrations that can be reached in the synovial fluid of arthritic patients. Both drugs decreased the chemotaxis induced by substance P and interleukin-8 at concentrations that can be reached in the synovial fluid during therapy. This result could be of importance for the use of these two non-steroidal antiinflammatory drugs in studying the development and progress of arthritic disease.
Sacerdote
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Department of Pharmacology, School of Medicine, University of Milan, Italy.
Panerai
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D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D016209:Interleukin-8 / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009000:Monocytes / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects*; D010894:Piroxicam / Q000031:analogs & derivatives* / Q000494:pharmacology; D013373:Substance P / Q000037:antagonists & inhibitors* / Q000494:pharmacology
D016209:Interleukin-8; D010894:Piroxicam; D013373:Substance P; D007213:Indomethacin; C032801:tenoxicam