Subpopulations of CD34-positive haemopoietic progenitors in fetal blood.
Flow cytometry was used to determine the percentage and number of circulating CD34+ cells in fetal blood from 100 pregnancies at 13-38 weeks gestation. When expressed as a percentage of the total number of lymphocytes, the proportion of CD34+ cells decreased exponentially from a mean of 11.1% (9.2 x 10(7)/l) at 13 weeks to 1.0% (3.0 x 10(7)/l) at 38 weeks (r = 0.751, P < 0.0001). The use of primitive fetal blood CD34+ progenitor cells for prenatal somatic gene therapy may have distinct advantages over postnatal somatic gene therapy.
Thilaganathan
B
B
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital School of Medicine, London.
Nicolaides
K H
KH
Morgan
G
G
D015703:Antigens, CD / Q000276:immunology*; D018952:Antigens, CD34; D003430:Cross-Sectional Studies; D005312:Fetal Blood / Q000276:immunology*; D005434:Flow Cytometry; D005865:Gestational Age; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D018655:Lymphocyte Count; D016131:Lymphocyte Subsets; D012044:Regression Analysis
D015703:Antigens, CD; D018952:Antigens, CD34