title: The plasma concentration of soluble Fc-gamma RIII is related to production of neutrophils.
abstract: Fc gamma RIII (the CD16-antigen), a low-affinity receptor for IgG, is expressed by neutrophils, natural killer lymphocytes and macrophages. A soluble form of Fc gamma RIII has been identified in human plasma. This soluble form of Fc gamma RIII (sFc gamma RIII) originates from release by neutrophils. In the present study we show by transfusions of plasma that contains sFc gamma RIII of one allotype (NA1-Fc gamma RIII) in recipients homozygous for the other allotype (NA2-Fc gamma RIII) that the clearance of sFc gamma RIII is about 0.7 ml/min. Because the concentration of sFc gamma RIII was found to be constant in a small cohort of donors followed for about 1.5 years, the half-life of NA1-sFc gamma RIII is about 1.8 d, assuming a one-compartment model. The plasma concentration of sFc gamma RIII depended mainly on the production of neutrophils in the bone marrow, and was not influenced by shifts of neutrophils from one pool to another (storage, marginating or circulating pool). Because Fc gamma RIII is only expressed on mature neutrophils, this implies that the concentration of sFc gamma RIII depends on production of mature neutrophils.
authors.affiliation: Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, Amsterdam.
authors.forename: T W
authors.initials: TW
authors.lastname: Huizinga
authors.forename: M
authors.initials: M
authors.lastname: de Haas
authors.forename: M H
authors.initials: MH
authors.lastname: van Oers
authors.forename: M
authors.initials: M
authors.lastname: Kleijer
authors.forename: H
authors.initials: H
authors.lastname: Vilé
authors.forename: P A
authors.initials: PA
authors.lastname: van der Wouw
authors.forename: A
authors.initials: A
authors.lastname: Moulijn
authors.forename: H
authors.initials: H
authors.lastname: van Weezel
authors.forename: D
authors.initials: D
authors.lastname: Roos
authors.forename: A E
authors.initials: AE
authors.lastname: von dem Borne
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000097:blood / Q000628:therapy; D002455:Cell Division; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology / Q000627:therapeutic use; D006207:Half-Life; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000097:blood / Q000628:therapy; D009503:Neutropenia / Q000378:metabolism / Q000628:therapy; D009504:Neutrophils / Q000166:cytology* / Q000378:metabolism; D017452:Receptors, IgG / Q000378:metabolism*
chemical_list: D017452:Receptors, IgG; D016179:Granulocyte Colony-Stimulating Factor