Prevention of experimental venous thrombosis in rabbits with low molecular weight heparin, dextran and their combinations, administered before or during induction of venous endothelial trauma.
An in vivo experimental venous thrombosis model based on endothelial damage and flow reduction was used to investigate the effect of low molecular weight heparin (LMWH) alone and in combination with dextran and the effect of surgical and endothelial trauma on thrombus formation, formation of occlusive thrombi and thrombus weights. Five groups with 15 rabbits in each were studied. Two groups received dalteparin (50 anti-Xa IU/kg i.v.) before surgical trauma or after, during the endothelial trauma and two groups received dalteparin (50 anti-Xa IU/kg i.v.) with dextran 70 (1 g/kg i.v.) before surgical trauma or after, during the endothelial trauma. Compared to a control group (saline) all treatment regimes reduced significantly the frequency of thrombosis and occlusive thrombi as well as thrombus weights. No significant difference was observed between the identical treatment groups when the substances were introduced before respective after surgical trauma. It is concluded, from the present study that thromboprophylaxis with LMWH in this particular in vivo model, given before or after surgical trauma is equally effective. Dextran has a certain augmenting thromboprophylactic effect when added to LMWH in this model.
Matthiasson
S E
SE
Department of Surgery, Lund University, Malmö General Hospital, Sweden.
Lindblad
B
B
Bergqvist
D
D
D000818:Animals; D003911:Dextrans / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000293:injuries; D005260:Female; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D008297:Male; D011183:Postoperative Complications; D011817:Rabbits; D013924:Thrombophlebitis / Q000209:etiology / Q000517:prevention & control*; D013997:Time Factors
D003911:Dextrans; D006495:Heparin, Low-Molecular-Weight