Group II phospholipase A2 in serum in critically ill surgical patients.
OBJECTIVE
To study the association of increased serum group II phospholipase A2 concentrations to C-reactive protein concentrations in the sera of critically ill surgical patients.


METHODS
Prospective study.


METHODS
Surgical intensive care unit (ICU) of a university hospital.


METHODS
Sixty-seven consecutive patients admitted to the surgical ICU.


METHODS
The catalytic activity of phospholipase A2 and the serum concentrations of group II phospholipase A2 and C-reactive protein were measured daily during each patient's stay in the ICU. A total of 205 blood samples were taken. In addition, the preoperative serum levels of group II phospholipase A2 were determined in patients admitted for cardiac surgery.


RESULTS
Serum group II phospholipase A2 values correlated statistically significantly with the catalytic activity of phospholipase A2 and serum C-reactive protein values. In particular, severe infections, diseases involving tissue destruction, and elective operations per se, caused considerable increases in serum group II phospholipase A2 concentrations.


CONCLUSIONS
Our results support the earlier presented idea that group II phospholipase A2 is an acute-phase reactant.
Grönroos
J M
JM
Department of Surgery, University of Turku, Finland.
Kuttila
K
K
Nevalainen
T J
TJ
D000209:Acute-Phase Proteins / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000032:analysis; D002384:Catalysis; D002648:Child; D002675:Child, Preschool; D004796:Clinical Enzyme Tests / Q000706:statistics & numerical data; D016638:Critical Illness; D005260:Female; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010741:Phospholipases A / Q000097:blood*; D054467:Phospholipases A2; D011446:Prospective Studies; D013514:Surgical Procedures, Operative / Q000706:statistics & numerical data
D000209:Acute-Phase Proteins; D002097:C-Reactive Protein; D010741:Phospholipases A; D054467:Phospholipases A2