title: Quality of life after the menopause: influence of hormonal replacement therapy.
abstract: OBJECTIVE
  Our purpose was to demonstrate the clinical efficacy and effect of hormone replacement therapy in menopause on quality of life.
  
  
  METHODS
  A randomized, open, 6-month comparison of hormone replacement therapy (estradiol transdermal system [Estraderm TTS] plus chlormadinone) and symptomatic treatment (verapipride) was performed. Analysis was by intention to treat.
  
  
  RESULTS
  In 499 postmenopausal women with moderate and severe symptoms enrolled by 101 physicians, hormone replacement therapy was superior to symptomatic treatment on all assessments of quality of life and clinical efficacy. The effects were independent of the incidence of hot flushes.
  
  
  CONCLUSIONS
  The effect of hormone replacement therapy on the quality of life of postmenopausal women was significantly superior to symptomatic treatment.
authors.affiliation: Hopital Boucicaut, Paris, France.
authors.forename: M A
authors.initials: MA
authors.lastname: Limouzin-Lamothe
authors.forename: N
authors.initials: N
authors.lastname: Mairon
authors.forename: C R
authors.initials: CR
authors.lastname: Joyce
authors.forename: M
authors.initials: M
authors.lastname: Le Gal
mesh_terms: D000279:Administration, Cutaneous; D002715:Chlormadinone Acetate / Q000627:therapeutic use; D002979:Climacteric / Q000187:drug effects; D004958:Estradiol / Q000627:therapeutic use*; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008875:Middle Aged; D017698:Postmenopause / Q000187:drug effects*; D011788:Quality of Life; D013469:Sulpiride / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D002715:Chlormadinone Acetate; D004958:Estradiol; D013469:Sulpiride; C027429:veralipride