title: Increased coexpression of CFTR and S100 calcium binding proteins MRP8 and MRP14 mRNAs in cystic fibrosis human tracheal gland cells.
abstract: We have demonstrated for the first time, by Northern analysis, the presence of the S-100 calcium binding proteins MRP8 (also called "cystic fibrosis protein") and MRP14 mRNAs in cultured human tracheal gland cells, obtained from normal and cystic fibrosis (CF) patients. A significant increase of these mRNAs in cells of CF origin (as well as that of CFTR mRNA) is shown. These results allow us to assume a potential pretranslational regulation of MRP8 and MRP14 gene expression related to the presence of a mutated CFTR gene.
authors.affiliation: Groupe de Recherche sur les Glandes Exocrines, Faculté de médecine, Marseille, France.
authors.forename: W
authors.initials: W
authors.lastname: Renaud
authors.forename: M
authors.initials: M
authors.lastname: Merten
authors.forename: C
authors.initials: C
authors.lastname: Figarella
mesh_terms: D000943:Antigens, Differentiation / Q000235:genetics*; D002135:Calcium-Binding Proteins / Q000235:genetics*; D040501:Calgranulin A; D040502:Calgranulin B; D003106:Colon / Q000378:metabolism; D003550:Cystic Fibrosis / Q000235:genetics*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D015870:Gene Expression; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*; D012333:RNA, Messenger / Q000235:genetics; D014132:Trachea / Q000502:physiology*
chemical_list: D000943:Antigens, Differentiation; C505032:CFTR protein, human; D002135:Calcium-Binding Proteins; D040501:Calgranulin A; D040502:Calgranulin B; D008565:Membrane Proteins; D012333:RNA, Messenger; D019005:Cystic Fibrosis Transmembrane Conductance Regulator