The use of intravenous gammaglobulin, heparin and aspirin in the maintenance of pregnancy of freeze thawed embryo in a patient with lupus-type anticoagulant.
A case of lupus anticoagulant and repeated fetal loss with a successful delivery of a healthy baby after transfer of thawed frozen embryos and intravenous immunoglobulin administration is described. The repeated fetal loss was due to vascular disturbances caused by lupus anticoagulants. Early implantation was not affected. Anticoagulants and/or steroids did not help in further establishing pregnancy. Intravenous immunoglobulin combined with heparin and aspirin led to term pregnancy and the birth of a healthy child.
Ron-el
R
R
Department of Obstetrics and Gynecology, Assaf Harofeh Medical Center, Tel Aviv University, Zerifin, Israel.
Vinder
A
A
Golan
A
A
Herman
A
A
Raziel
A
A
Caspi
E
E
Sidi
Y
Y
D000328:Adult; D016736:Antiphospholipid Syndrome / Q000188:drug therapy*; D001241:Aspirin / Q000008:administration & dosage*; D015925:Cryopreservation; D004359:Drug Therapy, Combination; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D006493:Heparin / Q000008:administration & dosage*; D006801:Humans; D007275:Injections, Intravenous; D011247:Pregnancy; D011250:Pregnancy Complications, Hematologic / Q000188:drug therapy*; D011256:Pregnancy Outcome; D005719:gamma-Globulins / Q000008:administration & dosage*
D005719:gamma-Globulins; D006493:Heparin; D001241:Aspirin