Gonadotropin and prolactin secretion in prepubertal female rats treated with 8-hydroxy-2-(di-n-propylamino) tetralin.
The effect of serotoninergic activation on gonadotropin and prolactin release were analysed in 16-day-old intact female rats. In the first experiment, females were decapitated 30 min after i.p. administration of 100 mg/kg of 5-hydroxytryptophan (5-HTP) or vehicle; in the second experiment the rats were decapitated 15 and 30 min after i.p. injection of vehicle or some doses (0.1, 1 and 10 mg/kg) of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT), a selective agonist of the serotonin (5-HT)1A receptors. We found that: 1) serum follicle-stimulating hormone (FSH), luteinizing-hormone (LH) and prolactin concentrations increased after 5-HTP administration; 2) serum LH and prolactin concentrations and pituitary prolactin content increased after administration of 8-OH-DPAT. Our results indicate that in prepubertal rats, activation of serotoninergic system stimulated gonadotropin and prolactin release, and that 5-HT1A receptors are involved in this effect. In addition, the simultaneous increase in serum and pituitary prolactin content suggests that 8-OH-DPAT enhances prolactin synthesis.
Aguilar
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E
Department of Physiology, Faculty of Medicine, University of Cordoba, Spain.
Ranchal
A
A
Aguilar
R
R
Pinilla
L
L
D006916:5-Hydroxytryptophan / Q000494:pharmacology; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006062:Gonadotropins / Q000378:metabolism*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007031:Hypothalamus / Q000187:drug effects / Q000378:metabolism; D007986:Luteinizing Hormone / Q000097:blood; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D011388:Prolactin / Q000096:biosynthesis / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects; D012701:Serotonin / Q000378:metabolism; D012741:Sexual Maturation / Q000502:physiology
D006062:Gonadotropins; D011985:Receptors, Serotonin; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D006916:5-Hydroxytryptophan