Intraperitoneal dizocilpine induces cortical spike-wave seizure discharges in rats.
Dizocilpine has been shown to be anticonvulsant in several experimental models of epilepsy. Nevertheless, 0.3 or 0.5 mg/kg intraperitoneal (i.p.) dizocilpine produced cortical spike-wave discharges (SWDs) in four of seven rats. The SWDs were accompanied by behavioral arrest, and also showed: a narrow range of induction times (around 25 min post-injection); hippocampal spikes closely correlated with the cortical spikes of the SWDs; a precipitous drop out of fast (45-100 Hz) cortical EEG; myoclonic bursts in nuchal EMG that began during the cortical slow waves. These findings suggest that patients being treated experimentally for stroke with non-competitive N-methyl-D-aspartate (NMDA) cation channel blockers should be monitored for seizures.
Feinberg
I
I
Department of Psychiatry, VA/UCD Sleep Laboratory TB 148, University of California, Davis, USA.
Campbell
I G
IG
Marrs
J C
JC
D000818:Animals; D016291:Dizocilpine Maleate / Q000633:toxicity*; D004569:Electroencephalography / Q000187:drug effects*; D004576:Electromyography / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects; D007274:Injections, Intraperitoneal; D008297:Male; D018696:Neuroprotective Agents / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced*
D018696:Neuroprotective Agents; D016291:Dizocilpine Maleate