title: Long-term follow-up study of adenomatous hyperplasia in liver cirrhosis.
abstract: The purpose of this study was to investigate the natural history of adenomatous hyperplasia (AH) in liver cirrhosis, which is suspected of being a precancerous condition of hepatocellular carcinoma (HCC). Sixteen patients with 19 histologically proven AH nodules were followed-up over time with ultrasonographic (US) examinations performed every 3-4 months. The biopsy was repeated whenever the volume of the lesion increased, its US pattern changed, or there was a change in the alpha-fetoprotein values. Thirteen out of 19 AH (68.4%) evolved toward HCC after 8-31 months (mean 14.2 months). Malignant transformation was proved in 7/18 AH within 1 year of its initial detection, in 12/15 AH within 2 years, and in 13/14 AH within 4 years. Six AH remained unchanged in size and US pattern for 9-70 months (mean 29.5 months). Long term follow-up of AH confirms that this lesion is a precursor of HCC.
authors.affiliation: Cattedra di Radiologia, Università di Pisa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Lencioni
authors.forename: D
authors.initials: D
authors.lastname: Caramella
authors.forename: C
authors.initials: C
authors.lastname: Bartolozzi
authors.forename: G
authors.initials: G
authors.lastname: Di Coscio
mesh_terms: D018248:Adenoma, Liver Cell / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D000368:Aged; D001706:Biopsy / Q000379:methods; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D002471:Cell Transformation, Neoplastic; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006965:Hyperplasia / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D008103:Liver Cirrhosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D008113:Liver Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions; D012189:Retrospective Studies; D013997:Time Factors; D014463:Ultrasonography; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000509:alpha-Fetoproteins