Predictive modelling of the 3-D structure of interleukin-13.
Several atomic structures are now available for the family of helical cytokines, which includes growth hormone as well as many of the interleukins. Using structural information from five members of this family, two alternative models of interleukin (IL)-13 are proposed. IL-13 has biological properties similar to those of IL-4 and, like the other interleukins, is a potentially important pharmaceutical target. The model of IL-13 is discussed and compared with the known interleukin structures.
Bamborough
P
P
Oxford Centre for Molecular Science, Physical Chemistry, Laboratory, UK.
Duncan
D
D
Richards
W G
WG
D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D004220:Disulfides / Q000737:chemistry; D016179:Granulocyte Colony-Stimulating Factor / Q000737:chemistry / Q000235:genetics; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000737:chemistry / Q000235:genetics; D013006:Growth Hormone / Q000737:chemistry / Q000235:genetics; D006801:Humans; D018793:Interleukin-13 / Q000737:chemistry* / Q000235:genetics; D007376:Interleukin-2 / Q000737:chemistry / Q000235:genetics; D015847:Interleukin-4 / Q000737:chemistry / Q000235:genetics; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011487:Protein Conformation; D015202:Protein Engineering; D017386:Sequence Homology, Amino Acid
D004220:Disulfides; D018793:Interleukin-13; D007376:Interleukin-2; D016179:Granulocyte Colony-Stimulating Factor; D015847:Interleukin-4; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D013006:Growth Hormone