[Clinical and prognostic significance of cellular immunity factors in patients with chronic liver diseases].
The paper presents the results of comprehensive studies of quantitative and functional parameters of cellular immunity in 283 patients with chronic liver diseases, using various rosette tests and monoclonal antibody phenotyping of immunocompetent cells. The pattern of changes in blood immunocompetent cells and immunoglobulins allows prediction of the natural history of chronic active hepatitis and hepatic cirrhosis of viral and alcoholic origin. The data on autorosette-forming and hepatic-specific lipoprotein-sensitive rosette-forming cells were found to be the most informative. As compared to health, there were substantial changes in the subpopulation composition of immunocompetent cells and immunoglobulins in hepatic cirrhosis. The changes in immunoregulatory theophylline-resistant (OKT4+, OKT8+, T mu and T gamma) and theophylline-sensitive E-rosetting, as well as effector (ICO11+ and ICOHM1+) cells were the leading immunopathogenetic link of hepatic cirrhosis. In the latter, the subpopulation composition of immunocompetent cells depended on the activity of a pathological process, the state of compensation, as well as the levels of HBsAg and blood anti-delta-antibodies. The subpopulation analysis of immunocompetent cells enabled the author to outline the specific features of the immune status of etiological types, as well as predictive types of chronic active hepatitis and hepatic cirrhosis, which may serve as evidence for goal-oriented immunomodulating therapy.
Podymova
S D
SD
Rachvelishvili
N B
NB
D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D015415:Biomarkers / Q000097:blood; D016516:CD4-CD8 Ratio; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000097:blood*; D006521:Hepatitis, Chronic / Q000276:immunology*; D006801:Humans; D007121:Immunocompetence; D007136:Immunoglobulins / Q000097:blood*; D008104:Liver Cirrhosis, Alcoholic / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011379:Prognosis; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015415:Biomarkers; D006514:Hepatitis B Surface Antigens; D007136:Immunoglobulins