Living related liver transplantation in children.
We reviewed 37 living related liver transplantations (LRLT) performed by our department during the last 27 months on children with end-stage liver disease. The patients were 15 boys and 22 girls aged 7 months to 15 years with biliary atresia (27), cryptogenic cirrhosis (3), Budd-Chiari syndrome (2), progressive intrahepatic cholestasis (2), protoporphyria (1), Wilson's disease (1), and fulminant hepatitis (1). The donors were 14 fathers and 23 mothers. Grafts were made from the left lateral segment (19), left lateral segment with partial S4 (11), left lobe (6), and right lobe (1). After graft harvesting all donors resumed normal liver function and normal life. The recipient underwent total hepatectomy with preservation of the inferior vena cava. FK506 and low-dose steroids were used for immunosuppression. The survival rate was 90% (27/30) in elective cases and 57% (4/7) in emergency cases. Six recipients had functioning grafts but died of extrahepatic complications. Hepatic vein stenosis occurred in 3 cases at 3 months after LRLT and was successfully treated by balloon dilatation. Portal vein stenosis occurred in 1 case at 8 months after LRLT and was also safely dilated. We incurred no hepatic artery thrombosis after introducing microsurgery techniques. Among 12 viral, 5 bacterial, and 3 fungal postoperative infections, 1 Candida pneumonia and 1 EBV-associated lymphoma were lethal. Three patients with ABO-blood group compatible grafts and one with an incompatible graft developed acute rejection, which was controlled in evey case by steroid bolus and/or increasing the dose of FK506. There were no definite episodes of rejection in ABO-identical cases. Children with moderate growth retardation (> or = -1.5 SD of normal growth) caught up in growth soon after LRLT, but those with severe retardation (<-1.5 SD) were slow to attain age-normal height. Appropriate timing, meticulous surgical procedures, and comprehensive management of complications are crucial for successful outcome with LRLT. LRLT is a promising option for alleviating the shortage of livers for pediatric transplantation and may be regarded as an independent modality to supplement cadaver donation.
Tanaka
K
K
Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Uemoto
S
S
Tokunaga
Y
Y
Fujita
S
S
Sano
K
K
Yamamoto
E
E
Sugano
M
M
Awane
M
M
Yamaoka
Y
Y
Kumada
K
K
D000208:Acute Disease; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D004630:Emergencies; D005260:Female; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000188:drug therapy / Q000453:epidemiology; D006085:Graft Survival; D006130:Growth Disorders / Q000453:epidemiology / Q000209:etiology; D006503:Hepatic Veins; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007223:Infant; D007239:Infections / Q000453:epidemiology / Q000382:microbiology; D017093:Liver Failure / Q000209:etiology / Q000601:surgery*; D016031:Liver Transplantation / Q000009:adverse effects* / Q000379:methods* / Q000401:mortality; D008297:Male; D008866:Microsurgery / Q000295:instrumentation / Q000379:methods; D011169:Portal Vein; D013256:Steroids / Q000627:therapeutic use; D016019:Survival Analysis; D015996:Survival Rate; D016559:Tacrolimus / Q000627:therapeutic use; D016896:Treatment Outcome; D014689:Venous Insufficiency / Q000453:epidemiology / Q000209:etiology / Q000628:therapy
D013256:Steroids; D016559:Tacrolimus