Schnitzler's syndrome associated with sensorimotor neuropathy.
We describe a patient with chronic urticaria in association with monoclonal IgM gammopathy (Schnitzler's syndrome). Seven years after the onset of the cutaneous lesions sensorimotor neuropathy developed. Myelin-associated glycoprotein was detected in the patient's serum. High doses of corticosteroids improved the skin condition but failed to prevent the neuropathy. Six months of treatment with immunoglobulins was without benefit.
Lebbe
C
C
Service de Dermatologie, Hôpital Saint-Louis, Paris, France.
Rybojad
M
M
Klein
F
F
Oksenhendler
E
E
Catala
M
M
Danon
F
F
Morel
P
P
D000368:Aged; D003711:Demyelinating Diseases / Q000150:complications*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications / Q000473:pathology*; D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D008297:Male; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D013577:Syndrome; D014581:Urticaria / Q000150:complications / Q000473:pathology*
D007075:Immunoglobulin M; D007145:Immunoglobulin kappa-Chains; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein