title: In vivo ventricular lesion growth in radiofrequency catheter ablation.
abstract: While radiofrequency catheter ablation has proved highly effective in the treatment of various supraventricular tachyarrhythmias, results in the treatment of ventricular tachycardia invite improvement. Knowledge of lesion growth in vivo might improve understanding of this discrepancy. So far only information from in vitro and in vivo studies using a small 2 mm tip electrode is available. Growth of ventricular radiofrequency lesions created with a 4 mm ablation electrode was studied in 11 closed-chest dogs. Endocardial ablations were performed at 31 left and 15 right ventricular sites at a power setting of 25 Watts and 5, 10, 20, 30 or 60 seconds pulse duration. Macroscopic and histopathologic lesion examination were performed after one week survival. Mean lesion volume increased from 52 mm3 after 5 seconds pulse duration to a maximum 388 mm3 and approximately 7 mm depth after 30 seconds. Lesions were prolate spheroid in form, with a sparing of subendocardial myocardium and maximum lesion diameter at some millimeters depth. Results indicate that catheter positioning at no more than 7 mm from the target is required for successful ablation. Due to lesion geometry, subendocardial targets demand even more exact catheter positioning, while subepicardial substrates may not be ammenable to ablation if ventricular wall thickness exceeds 7 mm at the ablation site. Repeated pulses at adjacent sites may be required for ablation of extended arrhythmogenic areas. Volume at 5 seconds was only approximately 15% of mature lesions. Therefore, the use of a short 'test pulse' after careful mapping may be useful to pinpoint the most appropriate site for ablation in discrete pathways.
authors.affiliation: Heart-Lung Institute, University Hospital, Utrecht, The Netherlands.
authors.forename: T A
authors.initials: TA
authors.lastname: Simmers
authors.forename: F H
authors.initials: FH
authors.lastname: Wittkampf
authors.forename: R N
authors.initials: RN
authors.lastname: Hauer
authors.forename: E O
authors.initials: EO
authors.lastname: Robles de Medina
mesh_terms: D000818:Animals; D017115:Catheter Ablation / Q000295:instrumentation / Q000379:methods; D002467:Cell Nucleus / Q000648:ultrastructure; D004285:Dogs; D006097:Granulation Tissue / Q000473:pathology; D006352:Heart Ventricles / Q000473:pathology / Q000601:surgery; D009206:Myocardium / Q000473:pathology*; D009336:Necrosis; D017180:Tachycardia, Ventricular / Q000473:pathology* / Q000601:surgery*; D013927:Thrombosis / Q000473:pathology; D013997:Time Factors