title: Biphenotypic M0 acute myeloid leukemia with trisomy-4.
abstract: We report here a rare case of biphenotypic M0 acute myeloid leukemia (AML) associated with trisomy 4. The literature of trisomy 4 in acute leukemia was reviewed. M2 and M4 AML are the most common FAB subtypes associated with trisomy 4. The clinical course of this entity is generally comparable with other non-trisomy 4 cases of AML. Despite the speculation made when first described, no specific environmental toxin has been found to be associated with this entity. C-kit oncogene has been mapped to chromosome 4 recently, and the role of this proto-oncogene in leukemogenesis of trisomy 4 associated leukemia should be further investigated.
authors.affiliation: Division of Hematology, University of Southern California, Los Angeles 90033.
authors.forename: Y K
authors.initials: YK
authors.lastname: Keung
authors.forename: B
authors.initials: B
authors.lastname: Kaplan
authors.forename: D
authors.initials: D
authors.lastname: Douer
mesh_terms: D000208:Acute Disease; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis; D018826:CD13 Antigens / Q000032:analysis; D002894:Chromosomes, Human, Pair 4; D004253:DNA Nucleotidylexotransferase / Q000032:analysis; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006801:Humans; D007951:Leukemia, Myeloid / Q000145:classification / Q000175:diagnosis / Q000235:genetics / Q000473:pathology*; D008297:Male; D009363:Neoplasm Proteins / Q000032:analysis; D010641:Phenotype; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000175:diagnosis; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D014314:Trisomy
chemical_list: D015703:Antigens, CD; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte; D014408:Biomarkers, Tumor; C000715470:MAS1 protein, human; D009363:Neoplasm Proteins; D000090063:Proto-Oncogene Mas; D004253:DNA Nucleotidylexotransferase; D018826:CD13 Antigens