[The dynamics of the structural-functional parameters of the chromatin in regenerating rat liver].
Three fractions of chromatin were obtained from nuclei of the regenerating rat liver: transcriptionally low active (TLA), transcriptionally active (TA) and membrane-bound (MB). Changes in fractions distribution, functional activities and structural reorganization during the cell cycle were found. At the peak of transcription (15 h after PHE) an increase in the relative content of TA and MB fractions as well as an increase of the level of incorporated labelled precursors in RNA of TLA and TA fractions compared to control were observed. At the peak of replication (20 h after PHE) the relative content of TA and MB fractions increased as well, while the level of incorporation of labelled precursors in RNA of TLA and TA fractions was significantly lower than in control.
Mozzhukhina
T G
TG
Glushakova
T V
TV
Litoshenko
A Ia
AIa
D000818:Animals; D002453:Cell Cycle; D002843:Chromatin / Q000378:metabolism / Q000648:ultrastructure*; D004247:DNA / Q000096:biosynthesis; D004261:DNA Replication; D005260:Female; D006498:Hepatectomy; D008099:Liver / Q000378:metabolism / Q000648:ultrastructure*; D008115:Liver Regeneration; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors; D014158:Transcription, Genetic
D002843:Chromatin; D012313:RNA; D004247:DNA