Effect of NG-nitro-L-arginine on shock induced by endotoxin and by platelet activating factor in dogs.
When NG-nitro-L-arginine, a nitric oxide synthase inhibitor, administration was started 5 min prior to shock induction in anesthetized dogs, a partial restoration was observed in endotoxin-induced shock and a complete recovery in platelet activating factor (PAF)-induced shock. When NG-nitro-L-arginine infusion was started 5 min after shock induction, no significant recovery was observed in endotoxin-induced shock and a complete recovery in PAF-induced shock. These data indicate that enhanced production of nitric oxide by vascular endothelial cells may contribute to endotoxin- or PAF-induced shock and also that some mediators including inducible nitric oxide synthase and/or cellular damage might be involved in endotoxin-induced shock.
Takekoshi
K
K
Department of Endocrinology, Dokkyo University School of Medicine, Tochigi, Japan.
Kasai
K
K
Suzuki
Y
Y
Sekiguchi
Y
Y
Banba
N
N
Nakamura
T
T
Shimoda
S
S
D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors; D000704:Analysis of Variance; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D004285:Dogs; D004730:Endothelium, Vascular / Q000166:cytology / Q000378:metabolism; D004731:Endotoxins / Q000633:toxicity; D005260:Female; D008297:Male; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase; D019335:Nitroarginine; D010972:Platelet Activating Factor / Q000633:toxicity; D012769:Shock / Q000139:chemically induced / Q000188:drug therapy*; D012772:Shock, Septic / Q000188:drug therapy*
D004731:Endotoxins; D010972:Platelet Activating Factor; D019335:Nitroarginine; D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases