[Cellular mechanisms of calcium regulation of cardiac rhythm in children with ectopic arrhythmias].
Regulation of intracellular calcium homeostasis by means of secondary mediators calmodulin and 4,5-inositol phosphates (products of phosphatidyl inositol hydrolysis) was studied in children with ectopic forms of arrhythmias. Alterations in the system calmodulin-Ca2+ and the activity of phosphoinosite metabolism correlated highly with clinical manifestations of the arrhythmias. The data obtained suggest that a number of molecular mechanisms and responsible for arrhythmias were realized in cell membranes and depended on a complex of intracellular messengers affected within various steps of the hormonal signal transmission.
Bershova
T V
TV
Bakanov
M I
MI
Bokeriia
L A
LA
Serbin
V I
VI
Mamedova
T N
TN
Mikhaĭlova
I L
IL
D002118:Calcium / Q000502:physiology*; D002147:Calmodulin / Q000502:physiology; D005117:Cardiac Complexes, Premature / Q000503:physiopathology*; D002648:Child; D006706:Homeostasis; D006801:Humans; D007295:Inositol Phosphates / Q000502:physiology; D015290:Second Messenger Systems; D015398:Signal Transduction; D013617:Tachycardia, Supraventricular / Q000503:physiopathology*
D002147:Calmodulin; D007295:Inositol Phosphates; C066454:inositol 4,5-bisphosphate; D002118:Calcium