[Molecular bases of cancer immunology].
The immune system is a tight network of different types of cells and molecules. The coordinated action of these elements mounts a precise immune response against tumor cells. However, these cells present several escape mechanisms, leading to tumor progression. This paper shows several cellular and molecular events involved in the regulation of the immune response against tumor cells. The interaction of several molecules such as MHC, TcR, adhesins, tumor antigens and cytokines are discussed, as well as the most recent knowledge about escape mechanisms and immunotherapy.
Barrera-Rodríguez
R
R
Departamento de Bioquímica, Instituto Nacional de Enfermedades Respiratorias, México.
Peralta-Zaragoza
O
O
Madrid-Marina
V
V
D000951:Antigens, Neoplasm / Q000276:immunology; D002448:Cell Adhesion; D003115:Colony-Stimulating Factors / Q000276:immunology; D006801:Humans; D007167:Immunotherapy; D016233:Immunotherapy, Active; D007372:Interferons / Q000276:immunology; D007378:Interleukins / Q000276:immunology; D008285:Major Histocompatibility Complex / Q000276:immunology; D009369:Neoplasms / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D011946:Receptors, Antigen / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology; D019139:Tumor Escape; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D000951:Antigens, Neoplasm; D003115:Colony-Stimulating Factors; D007378:Interleukins; D011946:Receptors, Antigen; D014409:Tumor Necrosis Factor-alpha; D007372:Interferons