An assessment of the efficacy and tolerability of nimesulide vs paracetamol in children after adenotonsillectomy.
The efficacy and tolerability of nimesulide were assessed and compared with those of paracetamol in the treatment of 35 children with pain and inflammation following adenotonsillectomy. The antipyretic and analgesic efficacy of the 2 drugs was similar, although more patients had complete remission of pain after 4 days of treatment with nimesulide. Both drugs were well tolerated, even though occasional elevation of transaminase enzymes and alkaline phosphatase was noted in the nimesulide-treated group. It is postulated that this effect may have been attributable to the volatile anaesthetics used during surgery.
Pasquale
G
G
Divisione Otorinolaringoiatrica, Istituto G. Gaslini, Genova, Italy.
Scaricabarozzi
I
I
D'Agostino
R
R
Taborelli
G
G
Vallarino
R
R
D000082:Acetaminophen / Q000627:therapeutic use*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D010149:Postoperative Pain / Q000188:drug therapy*; D016037:Single-Blind Method; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use*; D014068:Tonsillectomy / Q000009:adverse effects
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D000082:Acetaminophen; C012655:nimesulide