How neurotransmitters affect axoplasmic transport?
The effects of acetylcholine (ACh) and adrenaline on fast axoplasmic transport of cultured superior cervical ganglion cells were analyzed with a computer-assisted video-enhanced differential interference contrast microscopic system. ACh suppressed the transport reversibly in both anterograde and retrograde directions, and adrenaline increased the transport reversibly. These effects are related to the amount of c-AMP. This amount of c-AMP in connection with neurotransmitters controls the axoplasmic transport, which in turn is related to the activity of the neuron.
Takenaka
T
T
Department of Physiology, Yokohama City University, Japan.
Kawakami
T
T
Bandou
Y
Y
Hikawa
N
N
Gotoh
H
H
D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001370:Axonal Transport / Q000502:physiology*; D002478:Cells, Cultured; D000242:Cyclic AMP / Q000378:metabolism; D004837:Epinephrine / Q000494:pharmacology; D007091:Image Processing, Computer-Assisted; D051379:Mice; D008810:Mice, Inbred C57BL; D008858:Microscopy, Phase-Contrast; D016501:Neurites / Q000502:physiology / Q000648:ultrastructure; D018377:Neurotransmitter Agents / Q000502:physiology*; D015388:Organelles / Q000502:physiology; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000378:metabolism; D017783:Superior Cervical Ganglion / Q000166:cytology / Q000502:physiology
D018377:Neurotransmitter Agents; D011950:Receptors, Cholinergic; D000242:Cyclic AMP; D000109:Acetylcholine; D004837:Epinephrine