title: Filaggrin immunoreactive composite keratohyalin granules specific to acrosyringia and related tumours.
abstract: The luminal cell layer of acrosyringia contains heterogeneous globular keratohyalin granules, some of which contain basophilic and eosinophilic components. Using immunoelectron microscopy we found that the majority of the granules, which are basophilic, are strongly reactive to an anti-filaggrin antibody, while the minority, which are eosinophilic, are not. Similar heterogeneous keratohyalin granules were observed in syringomas and in an eccrine syringofibroadenoma. Since such granules are not normally observed in other human cutaneous epithelia, it is suggested that these composite keratohyalin granules with partial filaggrin immunoreactivity might serve as a useful marker for acrosyringial differentiation in both normal and pathological material.
authors.affiliation: Department of Cell Pathology, St John's Institute of Dermatology, St Thomas's Hospital, London, UK.
authors.forename: A
authors.initials: A
authors.lastname: Ishida-Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Iizuka
authors.forename: R A
authors.initials: RA
authors.lastname: Eady
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002648:Child; D003594:Cytoplasmic Granules / Q000378:metabolism / Q000473:pathology / Q000648:ultrastructure; D004439:Eccrine Glands; D004817:Epidermis / Q000378:metabolism / Q000473:pathology* / Q000648:ultrastructure; D005121:Extremities; D005260:Female; D018226:Fibroadenoma / Q000737:chemistry / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D000091344:Filaggrin Proteins; D006801:Humans; D006818:Hyalin / Q000378:metabolism; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins; D007633:Keratins / Q000378:metabolism; D008297:Male; D008854:Microscopy, Electron; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D012871:Skin Diseases / Q000276:immunology / Q000378:metabolism / Q000473:pathology*; D013544:Sweat Gland Neoplasms / Q000737:chemistry / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure; D018252:Syringoma / Q000737:chemistry / Q000276:immunology / Q000473:pathology* / Q000648:ultrastructure
chemical_list: C000717249:FLG protein, human; D000091344:Filaggrin Proteins; D007381:Intermediate Filament Proteins; C001500:keratohyalin; D007633:Keratins