Efficacy of intraperitoneal sodium carboxymethylcellulose in preventing postoperative adhesion formation.
Various regimens to reduce postoperative intraperitoneal adhesion formation have been tested; however, none has been consistently successful. The purpose of this study was to compare the efficacy of three compounds instilled into the peritoneal cavity--32% dextran 70, 0.9% normal saline and sodium carboxymethylcellulose--to no therapy on their ability to prevent postoperative adhesion formation in the New Zealand white rabbit. Bilateral posterior uterine horn incisions and cecal and transverse colon abrasions were performed during a two-phased study on each of 25 rabbits that were randomly assigned in a blind fashion into one of four study groups. Two weeks postoperatively, each rabbit underwent an autopsy to assess the magnitude of intraperitoneal adhesion formation. Adhesion scores were determined by counting the number of adhesions and assigning one or two points for each thin, filmy or dense, broad adhesion. As compared to no therapy, all three substances tested significantly reduced adhesion formation. Although 32% dextran 70 and 0.9% normal saline showed similar results, the degree of adhesion formation was reduced most significantly with sodium carboxymethylcellulose (P < .002) Sodium carboxymethylcellulose is effective in preventing postoperative adhesion formation in the New Zealand white rabbit.
Heidrick
G W
GW
Department of Obstetrics and Gynecology, University of Oklahoma College of Medicine, Oklahoma City.
Pippitt
C H
CH
Morgan
M A
MA
Thurnau
G R
GR
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000627:therapeutic use*; D003911:Dextrans / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery; D007322:Instillation, Drug; D010532:Peritoneal Diseases / Q000175:diagnosis / Q000517:prevention & control*; D011183:Postoperative Complications / Q000175:diagnosis / Q000517:prevention & control*; D011817:Rabbits; D011897:Random Allocation; D012720:Severity of Illness Index; D016037:Single-Blind Method; D012965:Sodium Chloride / Q000627:therapeutic use*; D000267:Tissue Adhesions
D003911:Dextrans; D012965:Sodium Chloride; D002266:Carboxymethylcellulose Sodium