Expression of 25(OH) vitamin D3 24-hydroxylase gene in glial cells.
The expression of the 25(OH) vitamin D3 24-hydroxylase gene was studied in C6 glioma and rat primary glial cell culture. The expression of the 25(OH)D3 24-hydroxylase gene was not detected in C6 glioma or glial cells cultured in a serum-free medium. However, the 25(OH)D3 24-hydroxylase mRNA was induced in a dose-dependent manner in cells treated with 1,25(OH)2D3. These findings provide further evidence for an involvement of vitamin D3 metabolites in brain function.
Naveilhan
P
P
INSERUM U 298 CHU Angers, France.
Neveu
I
I
Baudet
C
C
Ohyama
K Y
KY
Brachet
P
P
Wion
D
D
D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D015152:Blotting, Northern; D002117:Calcitriol / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D005910:Glioma / Q000201:enzymology; D006801:Humans; D009457:Neuroglia / Q000201:enzymology*; D012313:RNA / Q000096:biosynthesis; D051381:Rats; D014407:Tumor Cells, Cultured
D012313:RNA; D015090:25-Hydroxyvitamin D3 1-alpha-Hydroxylase; D002117:Calcitriol