title: Benign lymphangioendothelioma.
abstract: We describe a 40-year-old white man with a red-brown, indurated plaque on the proximal aspect of his right thigh. The lesion had been present since birth, and the patient had a 20-year clinical history of recurrent cellulitis in the same area. The histopathologic features of the lesion included permeation of the dermis by flattened, endothelium-lined channels without cellular atypia, hemorrhage, or inflammation. The endothelial cells were stained intensely with monoclonal antibody anti-CD34 (clone MY10). In addition, antibodies to factor VIII antigen, HLA-DR, smooth muscle actin, ICAM-1, and the lectin Ulex europaeus labeled the luminal cells. The basement membrane of the channels stained with anti-type IV collagen and laminin. Desmin-positive cells were abundant adjacent to the channels. Factor XIIIa stained both mononuclear cells and occasional dendritic cells in the perivascular area. Ki-67 immunolabeling could not be demonstrated on fresh or frozen tissue. Electron microscopy revealed the presence of both tight junctions and a well-formed, continuous basement membrane but the absence of Weibel-Palade bodies.
authors.affiliation: Department of Dermatology, Stanford University Medical Center, CA.
authors.forename: G S
authors.initials: GS
authors.lastname: Herron
authors.forename: R V
authors.initials: RV
authors.lastname: Rouse
authors.forename: J C
authors.initials: JC
authors.lastname: Kosek
authors.forename: B R
authors.initials: BR
authors.lastname: Smoller
authors.forename: B M
authors.initials: BM
authors.lastname: Egbert
mesh_terms: D000328:Adult; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34; D006801:Humans; D008202:Lymphangioma / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D008297:Male; D012878:Skin Neoplasms / Q000175:diagnosis / Q000276:immunology / Q000473:pathology*; D013848:Thigh
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018952:Antigens, CD34