Immunomodulation by soluble factors from tumor cells cultured in vivo in diffusion chambers.
The delayed-type hypersensitivity (DTH) response and lymphocyte-mediated angiogenesis were determined in mice bearing in vivo cultures of mammary tumor cells in diffusion chambers (DCs). Soluble tumor products which diffuse from the DCs were able to stimulate the immune system for both the DTH reaction and angiogenic activity by spleen cells.
Klein
S
S
Departamento de Investigaciones, Instituto de Oncologia A. H. Roffo, Universidad de Buenos Aires, Argentina.
Jasnis
M A
MA
Diament
M
M
Davel
L
L
Aguirre
J
J
de Bonaparte
Y P
YP
D000230:Adenocarcinoma / Q000098:blood supply / Q000276:immunology / Q000473:pathology*; D000818:Animals; D046508:Culture Techniques / Q000295:instrumentation / Q000379:methods; D004058:Diffusion; D006968:Hypersensitivity, Delayed; D008214:Lymphocytes / Q000276:immunology; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply / Q000276:immunology / Q000473:pathology*; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic; D014407:Tumor Cells, Cultured