1-Aryl-2-amino/hydrazino-4-phenyl-1,6-dihydro-1,3,5-triazine-6-thione and related thiocarbamides/thiosemicarbazides as antithyroidal agents.
Different 1-aryl-2-benzylmercapto-4-phenyl-1,6-dihydro-1,3,5-triazine-6- thiones have been synthesized by known methods. These triazines on treatment with ammonia/hydrazine hydrate afforded the corresponding 1-aryl-2-amino/hydrazino-4-phenyl-1,6-dihydro-1,3,5-triazine-6-thiones which on treatment with arylisothiocyanates afforded the related thiocarbamide/thiosemicarbazides. Some of these compounds show appreciable antithyroidal activity.
Prasad
R
R
Department of Chemistry, Banaras Hindu University, Varanasi, India.
Srivastava
P K
PK
D000818:Animals; D013956:Antithyroid Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013889:Thiouracil / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
D013956:Antithyroid Agents; D014227:Triazines; D013889:Thiouracil