'Perineuronal nets' around cortical interneurons expressing parvalbumin are rich in tenascin.
'Perineuronal nets' are ill-known structures enwrapping the cell bodies and proximal dendrites of certain neurons in the brain. It is as yet unclear if they represent a cytological entity or extracellular material. Using immunohistochemical methods we have detected the presence of the extracellular matrix-protein, tenascin, in the 'perineuronal nets' surrounding certain cortical interneurons. We have also shown that tenascin antibodies label the circumference of parvalbumin-immunoreactive neurons preferentially. We conclude that this classical matrix protein is a major component of 'perineuronal nets'. Therefore, 'perineuronal nets' may represent sites of privileged adhesion between nerve and glial cells.
Celio
M R
MR
Institute of Histology and General Embryology, University of Fribourg, Pérolles, Switzerland.
Chiquet-Ehrismann
R
R
D000818:Animals; D000918:Antibody Specificity; D015816:Cell Adhesion Molecules, Neuronal / Q000378:metabolism*; D002540:Cerebral Cortex / Q000166:cytology / Q000378:metabolism*; D004591:Electrophoresis, Polyacrylamide Gel; D016326:Extracellular Matrix Proteins / Q000378:metabolism*; D015151:Immunoblotting; D007150:Immunohistochemistry; D007395:Interneurons / Q000378:metabolism*; D008297:Male; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009457:Neuroglia / Q000378:metabolism; D010320:Parvalbumins / Q000096:biosynthesis*; D051381:Rats; D011919:Rats, Inbred Strains; D019063:Tenascin
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D009419:Nerve Tissue Proteins; D010320:Parvalbumins; D019063:Tenascin