Hyperthyroidism secondary to a pituitary adenoma secreting TSH, FSH, alpha-subunit and GH.
A 51-year-old man had been treated for hyperthyroidism with antithyroid drugs for 8 years. He was then found to have a large pituitary adenoma with biochemical evidence of overproduction of TSH, FSH and alpha-subunit. Subsequent immunocytochemical and tissue culture studies confirmed secretion of these hormones. In addition, the tumour stained for GH and was capable of GH production in vitro. This combination of hormones produced by a pituitary adenoma has not been previously reported.
Patrick
A W
AW
Department of Endocrinology, Walton Hospital, Liverpool, UK.
Atkin
S L
SL
MacKenzie
J
J
Foy
P M
PM
White
M C
MC
MacFarlane
I A
IA
D000236:Adenoma / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D005640:Follicle Stimulating Hormone / Q000378:metabolism; D015292:Glycoprotein Hormones, alpha Subunit / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006801:Humans; D006980:Hyperthyroidism / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000473:pathology; D010908:Pituitary Hormones, Anterior / Q000378:metabolism*; D010911:Pituitary Neoplasms / Q000150:complications* / Q000378:metabolism / Q000473:pathology; D013972:Thyrotropin / Q000378:metabolism
D015292:Glycoprotein Hormones, alpha Subunit; D010908:Pituitary Hormones, Anterior; D005640:Follicle Stimulating Hormone; D013972:Thyrotropin; D013006:Growth Hormone