Substance P containing polymer implants protect against striatal excitotoxicity.
The present study examined whether substance P (Sub P) could protect against quinolinic acid (QA)-induced lesions of the striatum, as measured by a loss of striatal D1 dopamine receptors. Sub P was extruded into Evac polymer rods for slow release. One 4 mm rod segment was implanted unilaterally into the striatum of each rat. One week later, animals received a striatal injection of QA (50, 75 or 100 nmol/microliters) medial to the implanted rod. Controls received QA alone. Three weeks later, there was a dose-dependent loss of D1 receptors following QA. Sub P rods protected the striatum from QA-induced D1 receptor loss at this time. These results support the neuroprotection role of Sub P on excitotoxicity.
Sanberg
P R
PR
Department of Surgery, University of South Florida, College of Medicine, Tampa 33612.
Emerich
D F
DF
Aebischer
P
P
Amisetti
S M
SM
Ouellette
W
W
Koutouzis
T K
TK
Cahill
D W
DW
Norman
A B
AB
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects*; D008297:Male; D011108:Polymers; D019736:Prostheses and Implants; D017378:Quinolinic Acid / Q000037:antagonists & inhibitors*; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects; D013373:Substance P / Q000032:analysis / Q000494:pharmacology*
D011108:Polymers; D017447:Receptors, Dopamine D1; D013373:Substance P; D017378:Quinolinic Acid