Prevalence of HCV-antibodies and HCV-RNA in donor blood in Tokushima Prefecture.
The incidence of C100-3 among the blood specimens qualified for transfusion according to the conventional criteria was 1.1%. The incidence of C100-3 in donor blood in Tokushima Prefecture is not significantly different from that reported for all Japan. Of the donors positive for the conventional screening test and C100-3, 73.6% showed high ALT levels. For all antibodies, the incidence of HCV-RNA was very low in the donors positive for a single antibody, but was high in those positive for multiple antibodies. All of the donors showing the 3 antibodies were positive for HCV-RNA. While a test for multiple antibodies is thought to be effective for the screening of HCV, more blood needs to be discarded, having a serious cost-performance problem. The O.D. value for C100-3 and the 2nd antibody seem to be useful reference value for antibody titers.
Honda
H
H
2nd Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.
Hibino
S
S
Nii
C
C
Horikita
M
M
Kamamura
M
M
Nishikado
T
T
Horie
T
T
Okahisa
T
T
Shibata
H
H
Shimizu
I
I
D000293:Adolescent; D000328:Adult; D001782:Blood Donors; D016174:Hepacivirus / Q000235:genetics / Q000276:immunology; D006508:Hepatitis Antibodies / Q000097:blood*; D018937:Hepatitis C Antibodies; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood*
D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D012367:RNA, Viral