[Serum pancreatic enzymes in patients with chronic renal failure on hemodialysis and in transplant patients].
OBJECTIVE
The aim of this study was to evaluate which of serum pancreatic enzymes was less influenced by chronic renal failure (CRF).


METHODS
40 patients with CRF undergoing hemodialysis (A group) and 24 renal transplant patients (B group) were considered. None of these patients showed clinical and instrumental findings of exocrine pancreas disease. Total amylase (T Amy), pancreatic isoamylase (P Amy), lipase (L) and Elastase-1 (E-1) were measured (in A group immediately before hemodialysis).


RESULTS
In A group T Amy and P Amy showed a significant correlation with serum creatinine level. In A group T Amy serum levels were increased in 65% of cases, P Amy in 72.5%, L in 47.5%, E-1 in 10%; in B group T Amy serum levels were increased in 41.6%, P Amy in 20.1%, L in 8.3% and E-1 in 4.1%. Statistical comparison showed a significantly lower percentages in B group considering P Amy (p < 0.001) and L (p = 0.003).


CONCLUSIONS
Our data suggest that E-1 is the only pancreatic enzyme whose specificity is not limited by CRF and thereby may be of value in the diagnosis of the exocrine pancreatic disease in patients with CRF on hemodialysis.
Manes
G
G
Centro Malattie Pancreas, Ospedale Cardarelli di Napoli.
Ricci
E
E
Rabitti
P G
PG
Caruso
S
S
Carraturo
I
I
Laccetti
M
M
Uomo
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D000681:Amylases / Q000097:blood; D002648:Child; D005260:Female; D006801:Humans; D007517:Isoamylase / Q000097:blood; D007676:Kidney Failure, Chronic / Q000201:enzymology* / Q000628:therapy*; D016030:Kidney Transplantation; D008049:Lipase / Q000097:blood; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000097:blood; D006435:Renal Dialysis
D008049:Lipase; D000681:Amylases; D007517:Isoamylase; D010196:Pancreatic Elastase