[The effect of a blockade of the dopamine D2 receptors in the cat neostriatum on the neuronal background activity and reactions of the reticular portion of the substantia nigra related to saccadic eye movements].
In cats, the activity of the substantia nigra reticular part's neurons was extracellularly recorded prior to and after haloperidol administration into the head of the caudate nucleus. The number of neurons with burst-type firing increased after the administration from 34 to 61 per cent. The excitatory/inhibitory responses ratio associated with saccadic eyes movements also increased from 0.04 to 0.4. The above changes seem to follow a disinhibition of the GABA-ergic neurons under the effect of blockade of the neostriatum D2 dopamine receptors.
Voloshin
M Ia
MIa
Lukhanina
E P
EP
Kolomiets
B P
BP
D000344:Afferent Pathways / Q000187:drug effects / Q000502:physiology; D000818:Animals; D002415:Cats; D003864:Depression, Chemical; D004585:Electrooculography; D006220:Haloperidol / Q000494:pharmacology; D008839:Microelectrodes; D008845:Microinjections; D017072:Neostriatum / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D010775:Photic Stimulation; D017448:Receptors, Dopamine D2 / Q000187:drug effects* / Q000502:physiology; D012438:Saccades / Q000187:drug effects* / Q000502:physiology; D013378:Substantia Nigra / Q000187:drug effects* / Q000502:physiology
D017448:Receptors, Dopamine D2; D006220:Haloperidol