Peculiarities of the clastogenic properties of chrysotile-asbestos fibers and zeolite particles.
It has been established that chrysotile-asbestos fibers and zeolite particles induce chromosome aberrations in human lymphocytes from whole blood cultures, peritoneal fluid cells and bone marrow cells of mice. It is shown that the level of cytogenetic response from the intraperitoneal administration of chrysotile-asbestos fibers and zeolite particles depends on the time of their exposure. Further, it is shown that SOD eliminates the cytogenetic effect of chrysotile-asbestos fibers, while catalase inhibits that of zeolite particles. Recommendations concerning testing for the mutagenic properties of mineral fibers and particles are given, and possible mechanisms of their damaging effects are discussed.
Durnev
A D
AD
Research Institute of Pharmacology of Russian Acad. Med., Moscow.
Daugel-Dauge
N O
NO
Korkina
L G
LG
Seredenin
S B
SB
D000818:Animals; D016587:Antimutagenic Agents; D017632:Asbestos, Serpentine / Q000037:antagonists & inhibitors / Q000633:toxicity*; D002374:Catalase / Q000494:pharmacology; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000633:toxicity*; D013482:Superoxide Dismutase / Q000494:pharmacology; D017641:Zeolites / Q000037:antagonists & inhibitors / Q000633:toxicity*
D016587:Antimutagenic Agents; D017632:Asbestos, Serpentine; D009153:Mutagens; D017641:Zeolites; D002374:Catalase; D013482:Superoxide Dismutase