title: The effects of dorsal and ventral noradrenergic system lesions with DSP-4 on emotional-defensive behavior and regional brain monoamines content in the cat.
abstract: As a result of selective lesions of dorsal (DB) and ventral (VB) noradrenergic system (DSP-4 i.c.) it was observed that these two systems are functionally differentiated and only DB participates in the regulation of post-carbachol emotional-defensive behavior in the cat. Following DB lesion an increase in emotional-defensive excitation occurred and HPLC analysis showed a significant reduction of NA concentration in the posterior hypothalamus, midbrain central gray matter and frontal cortex and decreased turnover of 5-HT in all "emotional brain areas" (hypothalamus, midbrain, amygdala, hippocampus) and frontal cortex. Following VB lesion there were no significant changes of post-carbachol defensive behavior and HPLC analysis showed a significant reduction of NA in the anterior and posterior hypothalamus, midbrain central gray matter and amygdala and an increased turnover of 5-HT in the posterior hypothalamus and midbrain central gray matter. The results obtained can be interpreted in relation to functional interactions between the NA and 5-HT systems.
authors.affiliation: Department of Neurophysiology, University of Lódź, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Wieczorek
authors.forename: A
authors.initials: A
authors.lastname: Romaniuk
mesh_terms: D018663:Adrenergic Agents / Q000494:pharmacology*; D000378:Agonistic Behavior / Q000187:drug effects / Q000502:physiology*; D000679:Amygdala / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology; D001596:Benzylamines / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000502:physiology*; D001931:Brain Mapping; D002217:Carbachol / Q000494:pharmacology; D002415:Cats; D004644:Emotions / Q000187:drug effects / Q000502:physiology*; D005260:Female; D005625:Frontal Lobe / Q000187:drug effects / Q000502:physiology; D006624:Hippocampus / Q000187:drug effects / Q000502:physiology; D007031:Hypothalamus / Q000187:drug effects / Q000502:physiology; D008297:Male; D009638:Norepinephrine / Q000502:physiology*; D010487:Periaqueductal Gray / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000502:physiology*
chemical_list: D018663:Adrenergic Agents; D001596:Benzylamines; D012701:Serotonin; D002217:Carbachol; C012102:DSP 4; D009638:Norepinephrine