title: Hyaline globules in uterine malignant mixed müllerian tumours. A diagnostic aid?
abstract: In order to evaluate the presence of hyaline globules (HGs) in uterine malignant mixed müllerian tumours (MMMT), and its possible diagnostic value in haematoxylin & eosin stained sections, a retrospective microscopic study of 38 cases (13 homologous and 25 heterologous) was carried out. Intra- and extracellular HGs were found in 31 MMMT (81.6%), 8 homologous (61.5%) and 23 heterologous (92%). In addition, strong alpha-1-antitrypsin immunoreactivity was also noted in the HGs of 10 cases out of 13 investigated. In initial diagnostic curettage material, HGs were observed in 18 of 22 cases (81.8%), 6 of 9 homologous (66.7%) and 12 of 13 heterologous (92.3%). In view of the high incidence of HGs in curettage specimens, their finding in haematoxylin & eosin stained sections could orientate a histopathologic preoperative diagnosis of MMMT, specially of heterologous type, and may be considered a diagnostic tool in order to indicate an early, planned therapy and staging in these neoplasms of poor prognosis.
authors.affiliation: Department of Pathology, Faculty of Medicine from Córdoba, Spain.
authors.forename: C
authors.initials: C
authors.lastname: Reymundo
authors.forename: M
authors.initials: M
authors.lastname: Toro
authors.forename: C
authors.initials: C
authors.lastname: Morales
authors.forename: A
authors.initials: A
authors.lastname: López-Beltrán
authors.forename: F
authors.initials: F
authors.lastname: Nogales
authors.forename: F
authors.initials: F
authors.lastname: Nogales
mesh_terms: D005260:Female; D006801:Humans; D006818:Hyalin; D002479:Inclusion Bodies / Q000648:ultrastructure*; D018200:Mixed Tumor, Mullerian / Q000175:diagnosis / Q000473:pathology*; D010503:Periodic Acid-Schiff Reaction; D012189:Retrospective Studies; D014594:Uterine Neoplasms / Q000175:diagnosis / Q000473:pathology*; D000515:alpha 1-Antitrypsin / Q000032:analysis
chemical_list: D000515:alpha 1-Antitrypsin