Linkage mapping of the Aldo-2, Pax-5, Ambp, and D4h9S3E loci on mouse chromosome 4 in the region of homology with human chromosome 9.
The genes for aldolase-B (ALDOB), the alpha 1-microglobulin/bikunin precursor (AMBP), the paired box gene PAX5, and the anonymous DNA marker D9S3 map to human chromosome 9 (HSA9). We have set out to map the mouse homologues of each of these genes. The mouse genes for Pax-5 and Ambp previously have been shown to map to MMU4. We have used an interspecific backcross to confirm these localizations and to map the mouse homologues of ALDOB (Aldo-2) and D9S3 (D4H9S3E) to the same chromosome. These genes were mapped with respect to the four anchor loci for MMU4. In addition, the panel of backcross DNAs had previously been typed for delta-amino levulinate dehydratase (Lv), orosomucoid-1 (Orm-1), and hexabrachion (Hxb), the human homologues of which map to HSA9q. The recombination distances +/- the standard error between each pair of loci are D4Nds4-1.6 +/- 1.1-D4H9S3E-4.0 +/- 1.7-Galt-0.8 +/- 0.8-Pax-5-4.8 +/- 1.9-Aldo-2-6.3 +/- 2.2-(Lv, Orm-1, Ambp)-1.6 +/- 1.1-Hxb-4.0 +/- 1.7-Tyrp-1-4.8 +/- 1.9-Ifa. The data from this study have extended the known region of conserved synteny between human chromosome 9 and mouse chromosome 4.
Pilz
A
A
Department of Genetics and Biometry, University College London, United Kingdom.
Fountain
J
J
Peters
J
J
Abbott
C
C
D000510:Alpha-Globulins / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9; D005634:Fructose-Bisphosphate Aldolase / Q000235:genetics*; D005801:Genes, Homeobox; D008040:Genetic Linkage; D005819:Genetic Markers; D006023:Glycoproteins / Q000235:genetics*; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D008562:Membrane Glycoproteins; D051379:Mice / Q000235:genetics*; D011480:Protease Inhibitors; D011498:Protein Precursors / Q000235:genetics; D014360:Trypsin Inhibitor, Kunitz Soybean
D000510:Alpha-Globulins; D005819:Genetic Markers; D006023:Glycoproteins; D007527:Isoenzymes; D008562:Membrane Glycoproteins; D011480:Protease Inhibitors; D011498:Protein Precursors; C109148:SPINT2 protein, human; C016001:alpha-1-microglobulin; D014360:Trypsin Inhibitor, Kunitz Soybean; D005634:Fructose-Bisphosphate Aldolase