title: Antimutagenicity in Euglena gracilis.
abstract: The genotoxic effect of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) and furadantine (Fu) was significantly decreased by standard antimutagens (ascorbic acid, alpha-tocopherol, chlorophyllin and sodium selenite) in the unicellular flagellate Euglena gracilis. The effects of these compounds were verified also by a bacterial test in which three strains of Salmonella typhimurium, TA97, TA100, and TA102, were used. The above compounds were antimutagenic in strains of bacteria used, except for chlorophyllin which had no effect on strain TA102.
authors.affiliation: Institute of Molecular and Subcellular Biology, Comenius University, Bratislava, Slovak Republic.
authors.forename: P
authors.initials: P
authors.lastname: Foltínová
authors.forename: N
authors.initials: N
authors.lastname: Lahitová
authors.forename: L
authors.initials: L
authors.lastname: Ebringer
mesh_terms: D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D005056:Euglena gracilis / Q000187:drug effects* / Q000235:genetics; D008769:Methylnitronitrosoguanidine / Q000633:toxicity; D009152:Mutagenicity Tests / Q000379:methods*; D009582:Nitrofurantoin / Q000633:toxicity
chemical_list: D016587:Antimutagenic Agents; D008769:Methylnitronitrosoguanidine; D009582:Nitrofurantoin