Mapping of the 19p13 breakpoint in an ovarian carcinoma between the INSR and TCF3 loci.
Chromosome rearrangements involving band 19p13 have been described in about half of all ovarian carcinomas. Four ovarian carcinomas with translocations of 19p13 were investigated with 11 DNA probes for markers localized to this band. All markers exhibited normal restriction patterns, suggesting that they were not rearranged. The 19p13 breakpoint of one tumor was mapped to a location between the INSR and the TCF3 loci.
Aman
P
P
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Pejovic
T
T
Wennborg
A
A
Heim
S
S
Mitelman
F
F
D002277:Carcinoma / Q000235:genetics*; D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D005819:Genetic Markers; D006801:Humans; D010051:Ovarian Neoplasms / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D011972:Receptor, Insulin / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics; D014178:Translocation, Genetic
D015342:DNA Probes; D004273:DNA, Neoplasm; D005819:Genetic Markers; D014157:Transcription Factors; D011972:Receptor, Insulin