Chromosome abnormalities in benign prostatic hyperplasia.
We combined conventional cytogenetic analysis and fluorescence in situ hybridization of short-term cultures of 28 samples from benign prostatic hyperplasia. Loss of the Y chromosome was the most common chromosome change, followed by trisomy 7. Trisomy 7, however, may be unrelated to the origin of benign prostate hyperplasia, in which the only and not very specific change seems to be the loss of the Y chromosome.
Aly
M S
MS
Centre for Human Genetics, University of Leuven, Belgium.
Dal Cin
P
P
Van de Voorde
W
W
van Poppel
H
H
Ameye
F
F
Baert
L
L
Van den Berghe
H
H
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000818:Animals; D002478:Cells, Cultured; D002872:Chromosome Deletion; D002897:Chromosomes, Human, Pair 7; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008875:Middle Aged; D011470:Prostatic Hyperplasia / Q000235:genetics*; D011817:Rabbits; D014314:Trisomy; D014998:Y Chromosome