Some desmoid tumors are characterized by trisomy 8.
Ten desmoid tumors were examined by chromosome banding analysis and by in situ hybridization on short-term cultures and frozen sections. Trisomy 8 was detected in four out of ten tumors, of which only one had shown trisomy 8 by karyotype analysis. Since trisomy 8 has been reported in superficial fibromatoses, which are clinically distinct but histologically similar to desmoid tumors, the occurrence of trisomy 8 in both may be a further indication of a close relationship.
Dal Cin
P
P
Centre for Human Genetics, University of Leuven, Belgium.
Sciot
R
R
Aly
M S
MS
Delabie
J
J
Stas
M
M
De Wever
I
I
Van Damme
B
B
Van den Berghe
H
H
D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8; D005260:Female; D018221:Fibromatosis, Abdominal / Q000235:genetics* / Q000473:pathology; D018222:Desmoid Tumors / Q000235:genetics* / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014314:Trisomy; D014407:Tumor Cells, Cultured