title: SLe(x) expression of normal CD34 positive bone marrow haemopoietic progenitor cells.
abstract: We investigated sialylated Lewis x (sLe(x)) antigen expression on CD34 positive (CD34+) haemopoietic progenitors in the bone marrow of eight healthy volunteers using monoclonal antibodies. We found that in all the samples examined, CD34+ bone marrow progenitors strongly expressed the sLe(x) antigen. This contradicts previous publications which reported sLe(x) expression on malignant blast cells but not on normal CD34+ progenitor cells.
authors.affiliation: Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London.
authors.forename: M
authors.initials: M
authors.lastname: Karakantza
authors.forename: F M
authors.initials: FM
authors.lastname: Gibson
authors.forename: J D
authors.initials: JD
authors.lastname: Cavenagh
authors.forename: S E
authors.initials: SE
authors.lastname: Ball
authors.forename: M Y
authors.initials: MY
authors.lastname: Gordon
authors.forename: E C
authors.initials: EC
authors.lastname: Gordon-Smith
mesh_terms: D015703:Antigens, CD / Q000032:analysis*; D018952:Antigens, CD34; D001853:Bone Marrow / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D016256:Lewis X Antigen / Q000032:analysis*
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34; D016256:Lewis X Antigen