[Role of neuropeptides in the lateralization of brain (as exemplified by behavior in radial maze].
The effects of thyroid-releasing hormone (TRH) and substance P (SP) on rat brain lateralization have been studied by three test methods: T-maze, 12-arm radial maze (r. m.) and rotometry. The animals were given 415 micrograms/kg of TRH i. p. or 25 micrograms/kg of TRH intranasally or 50 micrograms/kg of SP i. p. The number of errors and time of task solution in r. m. decreased in the first day of TRH administration. Simultaneously, left-sided deviations in maze-arm choices appeared in some rats' strategy, which made successive arm choices possible. SP induced search activity in rats at the stage of acquisition, yet SP given in the period of tolerant r. m. performance caused degradation of short-time memory and right-sided lateralization appeared.
Chepurnov
S A
SA
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D004780:Environment, Controlled; D007839:Functional Laterality / Q000187:drug effects*; D008570:Memory, Short-Term / Q000187:drug effects*; D051381:Rats; D013373:Substance P / Q000494:pharmacology*; D013973:Thyrotropin-Releasing Hormone / Q000494:pharmacology*
D013373:Substance P; D013973:Thyrotropin-Releasing Hormone