[Possibilities of using Salmonella cya, crp mutants as vectors of an oral recombinant vaccine].
The Salmonella typhimurium B-2/1 double mutant with cya and crp mutations was obtained by a recombination process. The mutant exhibited a low virulence and inability to utilize citrate. In terms of these properties, the mutant differs from the wild-type strain. The mutant is able to persist in the body of mice, cattle, and monkeys, provoking the immune response to its oral administration.
Boĭchenko
M N
MN
Vorob'ev
A A
AA
Gusev
V V
VV
Tymchuk
S N
SN
D000284:Administration, Oral; D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000235:genetics* / Q000276:immunology; D002417:Cattle; D051379:Mice; D009154:Mutation; D010215:Papio; D012486:Salmonella typhimurium / Q000235:genetics* / Q000276:immunology / Q000472:pathogenicity; D014614:Vaccines, Synthetic / Q000008:administration & dosage / Q000235:genetics* / Q000276:immunology; D014774:Virulence
D001428:Bacterial Vaccines; D014614:Vaccines, Synthetic