title: Thalifaberidine, a cytotoxic aporphine-benzylisoquinoline alkaloid from Thalictrum faberi.
abstract: From Thalictrum faberi, thalifaberidine [1], a new aporphine-benzylisoquinoline alkaloid, together with four known alkaloids, thalifaramine [2], thalifaricine [3], thalifarazine [4], and thalifaronine [5], were isolated. Thalifaberidine [1] was identified as 6',8-desmethylthalifaberine, and its 1H- and 13C-nmr data were completely assigned through the use of one- and two-dimensional nmr techniques. Thalifaberidine [1], thalifaberine [6], and thalifasine [7] showed cytotoxic activity against several human cancer cell lines, as well as antimalarial activity.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612.
authors.forename: L Z
authors.initials: LZ
authors.lastname: Lin
authors.forename: S F
authors.initials: SF
authors.lastname: Hu
authors.forename: K
authors.initials: K
authors.lastname: Zaw
authors.forename: C K
authors.initials: CK
authors.lastname: Angerhofer
authors.forename: H
authors.initials: H
authors.lastname: Chai
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
authors.forename: J
authors.initials: J
authors.lastname: Lin
authors.forename: D M
authors.initials: DM
authors.lastname: Zheng
mesh_terms: D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D001060:Aporphines / Q000737:chemistry / Q000302:isolation & purification*; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification* / Q000494:pharmacology; D006678:HIV / Q000201:enzymology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D051379:Mice; D018894:Reverse Transcriptase Inhibitors; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D001060:Aporphines; D004365:Drugs, Chinese Herbal; D018894:Reverse Transcriptase Inhibitors; C091306:thalifaberidine