title: Localized, late-onset, high-grade lymphoma following bone marrow transplantation: response to combination chemotherapy.
abstract: Non-Hodgkin's lymphoma is the commonest secondary cancer following bone marrow transplantation (BMT). We report the case of a 42-year-old man who developed a laryngeal high-grade B-cell lymphoma 5 years following a matched T depleted BMT for CML. Polymerase chain reaction (PCR) analysis using the microsatellite marker Cyp 19 demonstrated the donor origin of involved tissue. Epstein-Barr virus (EBV) genomic sequences were identified by PCR. Although EBV related B-cell lymphoproliferative disorders (BLPD) post BMT are difficult to treat, there was a complete remission in this patient following three courses of chemotherapy (CHOP) administered with G-CSF. This case of late-onset BLPD appears clinically distinct from the well-defined, aggressive, early post-transplant BLPD.
authors.affiliation: Department of Haematology, St James's Hospital, Dublin, Ireland.
authors.forename: J M
authors.initials: JM
authors.lastname: O'Riordan
authors.forename: K
authors.initials: K
authors.lastname: Molloy
authors.forename: D S
authors.initials: DS
authors.lastname: O'Briain
authors.forename: N
authors.initials: N
authors.lastname: Corbally
authors.forename: D
authors.initials: D
authors.lastname: Devaney
authors.forename: D
authors.initials: D
authors.lastname: McShane
authors.forename: N
authors.initials: N
authors.lastname: Considine
authors.forename: S R
authors.initials: SR
authors.lastname: McCann
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006566:Herpesviridae Infections / Q000150:complications*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000628:therapy; D008297:Male; D009333:Neck / Q000000981:diagnostic imaging; D016609:Neoplasms, Second Primary / Q000382:microbiology; D016133:Polymerase Chain Reaction; D011241:Prednisone / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D014412:Tumor Virus Infections / Q000150:complications*; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone