IgG Fc receptors that resemble class I major histocompatibility complex antigens.
(1) The intestinal Fc receptors of neonatal rats and mice consists of beta 2m and an alpha-chain that is similar to those of MHC class I and CD1 antigens. (2) Mouse and rat FcRns are highly conserved. There are no amino acid substitutions in the 90 amino acid alpha 3 domain, and only one in the 40 amino acid cytoplasmic tail. (3) Despite its similarity to class I MHC antigens, the mouse FcRn alpha-chain is encoded outside the MHC, on chromosome 7.
Simister
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Rosenstiel Center for Basic Biomedical Sciences and Biology Department, Brandies University, Waltham, MA 02254-9110.
D000595:Amino Acid Sequence; D000818:Animals; D000831:Animals, Newborn; D015703:Antigens, CD / Q000235:genetics; D018949:Antigens, CD1; D002874:Chromosome Mapping; D017124:Conserved Sequence; D005260:Female; D015789:HLA-A2 Antigen / Q000737:chemistry; D015395:Histocompatibility Antigens Class I / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D007074:Immunoglobulin G / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D051379:Mice; D008969:Molecular Sequence Data; D011247:Pregnancy; D051381:Rats; D017452:Receptors, IgG / Q000737:chemistry* / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D015703:Antigens, CD; D018949:Antigens, CD1; D015789:HLA-A2 Antigen; D015395:Histocompatibility Antigens Class I; D007074:Immunoglobulin G; D017452:Receptors, IgG