Fetal lung maturation in congenital diaphragmatic hernia.
OBJECTIVE
Our purpose was to determine whether congenital diaphragmatic hernia is associated with abnormalities of fetal lung maturation.


METHODS
We measured surfactant protein A and saturated phosphatidylcholine in amniotic fluid from 19 pregnancies with a prenatal diagnosis of congenital diaphragmatic hernia (gestational age 16 to 40 weeks) and 48 control pregnancies (gestational age 16 to 39 weeks). Results were compared by analysis of covariance.


RESULTS
Beyond 34 weeks of gestation there was a progressive rise in amniotic fluid surfactant protein A and saturated phosphatidylcholine in control pregnancies, whereas in most fetuses with prenatal diagnosis of congenital diaphragmatic hernia these values remained low (p < 0.01). Amniotic fluid surfactant protein A was lower in fetuses with congenital diaphragmatic hernia who died or required extracorporeal membrane oxygenation than in survivors treated with conventional management (4.9 +/- 2.9 vs 16.8 +/- 5.7 micrograms/ml surfactant protein A, respectively, p < 0.05 by Mann-Whitney U test).


CONCLUSIONS
There are decreased surfactant components in amniotic fluid in many pregnancies complicated by congenital diaphragmatic hernia, which may reflect fetal lung immaturity or hypoplasia.
Moya
F R
FR
Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas 75235-9063, USA.
Thomas
V L
VL
Romaguera
J
J
Mysore
M R
MR
Maberry
M
M
Bernard
A
A
Freund
M
M
D000649:Amniocentesis; D015415:Biomarkers / Q000032:analysis; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D005313:Fetal Death; D005333:Fetus; D005865:Gestational Age; D006023:Glycoproteins / Q000032:analysis; D006548:Hernia, Diaphragmatic / Q000175:diagnosis* / Q000503:physiopathology; D065630:Hernias, Diaphragmatic, Congenital; D006801:Humans; D008168:Lung / Q000196:embryology*; D010713:Phosphatidylcholines / Q000032:analysis*; D011247:Pregnancy; D011510:Proteolipids / Q000032:analysis*; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants / Q000032:analysis*; D012016:Reference Values
D015415:Biomarkers; D006023:Glycoproteins; D010713:Phosphatidylcholines; D011510:Proteolipids; D037661:Pulmonary Surfactant-Associated Proteins; D011663:Pulmonary Surfactants