title: Neurological dysfunction in asymptomatic HIV-1 infected men: evidence from evoked potentials. HNRC Group.
abstract: Neurological function in 159 subjects infected by the human immunodeficiency virus (HIV) who had no neurological symptoms or signs (129 asymptomatic, 30 with ARC/AIDS) was compared to that of 62 controls by means of pattern-reversal evoked potentials (PREPs), brain-stem auditory evoked potentials (BAEPs), median nerve somatosensory evoked potentials (MSEPs), tibial nerve somatosensory evoked potentials (TSEPs) and nerve conduction studies (NCSs). Central nervous system somatosensory conduction from lumbar cord to cortex was prolonged in both asymptomatic seropositive and ARC/AIDS groups, while peripheral somatosensory conduction, NCSs and PREP delays occurred only in the ARC/AIDS group. BAEPs did not show significant differences among groups. TSEPs were abnormal in 8% of asymptomatic carriers and 43% of patients with ARC/AIDS, MSEPs in 7% and 20%, PREPs in 4% and 0%, and BAEPs in 1% and 0% respectively. One or more evoked potentials were abnormal in 18 of 129 (14%) asymptomatic carriers and 13 of 30 (43%) subjects with ARC/AIDS as compared with 1 of 62 (2%) seronegative controls. We conclude that asymptomatic HIV carriers have subclinical neurological impairment of central somatosensory function and that the neurological impairment increases with disease progression to involve peripheral nerves and visual system.
authors.affiliation: Department of Neurosciences, University of California, San Diego School of Medicine, La Jolla.
authors.forename: V J
authors.initials: VJ
authors.lastname: Iragui
authors.forename: J
authors.initials: J
authors.lastname: Kalmijn
authors.forename: L J
authors.initials: LJ
authors.lastname: Thal
authors.forename: I
authors.initials: I
authors.lastname: Grant
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D004569:Electroencephalography; D005071:Evoked Potentials / Q000502:physiology*; D015658:HIV Infections / Q000503:physiopathology*; D015497:HIV-1; D006801:Humans; D008297:Male; D008875:Middle Aged; D009422:Nervous System Diseases / Q000382:microbiology / Q000503:physiopathology*; D009431:Neural Conduction / Q000502:physiology; D011930:Reaction Time / Q000502:physiology