title: Renal tubular acidosis preceding systemic lupus erythematosus.
abstract: A 10-year-old girl with distal renal tubular acidosis (RTA) for 4 years (adequately treated for 3 years) developed clinical features suggesting systemic lupus erythematosus (SLE) with supportive laboratory evidence. She had heavy proteinuria and a decreased creatinine clearance (CCr). Renal biopsy showed diffuse proliferative and sclerosing glomerulonephritis with severe tubulointerstitial changes. Following treatment with corticosteroids and cyclophosphamide, she had a clinical remission, an increase in CCr and recovery from systemic acidosis. It is likely that distal RTA in this patient was a manifestation of SLE.
authors.affiliation: Department of Paediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
authors.forename: A
authors.initials: A
authors.lastname: Bagga
authors.forename: Y
authors.initials: Y
authors.lastname: Jain
authors.forename: R N
authors.initials: RN
authors.lastname: Srivastava
authors.forename: U N
authors.initials: UN
authors.lastname: Bhuyan
mesh_terms: D000141:Acidosis, Renal Tubular / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D002648:Child; D003520:Cyclophosphamide / Q000627:therapeutic use; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D007668:Kidney / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications* / Q000188:drug therapy
chemical_list: D005938:Glucocorticoids; D003520:Cyclophosphamide