title: Potassium and calcium channel dependence of bursting in cultured neuronal networks.
abstract: Increases in extracellular potassium concentrations reliably increase burst rates in cultured fetal murine spinal cord networks. This effect could be mimicked by either blocking voltage-gated potassium conductances or facilitating excitatory synaptic interactions, but not by blocking specific calcium-dependent potassium conductances or tonic depolarization. Spontaneous bursting in cultured networks is apparently dependent on potassium currents and intracellular calcium levels, but not on the pharmacologically characterized calcium-dependent potassium conductances.
authors.affiliation: Center for Network Neuroscience, University of North Texas, Denton 76203.
authors.forename: B K
authors.initials: BK
authors.lastname: Rhoades
authors.forename: G W
authors.initials: GW
authors.lastname: Gross
mesh_terms: D015761:4-Aminopyridine / Q000494:pharmacology; D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D001030:Apamin / Q000494:pharmacology; D017609:Barium Compounds / Q000494:pharmacology; D001640:Bicuculline / Q000031:analogs & derivatives / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology*; D002586:Cesium / Q000494:pharmacology; D018999:Charybdotoxin; D002712:Chlorides / Q000494:pharmacology; D002794:Choline / Q000494:pharmacology; D004110:Diltiazem / Q000494:pharmacology; D004594:Electrophysiology / Q000295:instrumentation / Q000379:methods; D005333:Fetus; D015636:Magnesium Chloride / Q000494:pharmacology; D051379:Mice; D009116:Muscarine / Q000494:pharmacology; D016202:N-Methylaspartate / Q000494:pharmacology; D009415:Nerve Net / Q000502:physiology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009924:Organ Culture Techniques; D010042:Ouabain / Q000494:pharmacology; D015221:Potassium Channels / Q000187:drug effects / Q000502:physiology*; D011189:Potassium Chloride / Q000494:pharmacology; D012604:Scorpion Venoms / Q000494:pharmacology; D013116:Spinal Cord / Q000502:physiology*; D019789:Tetraethylammonium; D013757:Tetraethylammonium Compounds / Q000494:pharmacology; D014701:Veratridine / Q000494:pharmacology
chemical_list: D017609:Barium Compounds; D015220:Calcium Channels; D002712:Chlorides; D015221:Potassium Channels; D012604:Scorpion Venoms; D013757:Tetraethylammonium Compounds; D015636:Magnesium Chloride; C024986:barium chloride; D018999:Charybdotoxin; D002586:Cesium; D015124:8-Bromo Cyclic Adenosine Monophosphate; D001030:Apamin; C017069:bicuculline methiodide; D010042:Ouabain; D016202:N-Methylaspartate; D019789:Tetraethylammonium; D011189:Potassium Chloride; D014701:Veratridine; D009116:Muscarine; D015761:4-Aminopyridine; D004110:Diltiazem; C028019:cesium chloride; D002794:Choline; D000109:Acetylcholine; D001640:Bicuculline