Striking similarities between HIV-1 Env protein and the apoptosis mediating cell surface antigen Fas. Role in the pathogenesis of AIDS.
We have designed a computer strategy in order to detect systematically peptidic sites with the potential of interfering with the immune regulatory processes. Applying this software to HIV-1 proteins has led us to unravel a few peptidic sites which could either act directly or be the targets of an auto-immune reaction during HIV-1 infection. We previously reported that the SLWDQ pentapeptide identity with a critical site of CD4 could trigger in HIV-1 infected individuals both an humoral and a cellular autoimmune reaction. In this study, we focused on surprising similitudes unravelled by our software Automat, between HIV-1/2 and another immunoregulatory molecule, the Fas protein which is also called the apoptosis-mediating cell-surface antigen.
Zagury
J F
JF
Laboratoire de Physiopathologie Cellulaire, Université P & M Curie, Paris, France.
Cantalloube
H
H
Achour
A
A
Cho
Y Y
YY
Fall
L
L
Lachgar
A
A
Chams
V
V
Astgen
A
A
Biou
D
D
Picard
O
O
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000378:metabolism; D000954:Antigens, Surface / Q000737:chemistry*; D015704:CD4 Antigens / Q000737:chemistry / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000737:chemistry* / Q000276:immunology; D015497:HIV-1; D066298:In Vitro Techniques; D017386:Sequence Homology, Amino Acid; D012984:Software; D019014:fas Receptor
D000954:Antigens, Surface; D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D019014:fas Receptor