title: On the other hand: the stereoselectivity of drug action at ion channels.
abstract: Ion channels are pharmacological receptors with specific drug binding sites. These binding sites define specific structure-function relationships for the actions of drug classes. Interpretation of these structure-function relationships may be complex because of state-dependent drug-channel interactions. These state-dependent interactions determine affinity and access of drug to binding sites and may result in both quantitative and qualitative changes in structure-function relationships including stereoselectivity. A channel-active drug may exhibit antagonist or activator properties according to membrane potential and the stereoselectivity of interaction may also change with channel state.
authors.affiliation: School of Pharmacy, State University of New York, Buffalo 14260.
authors.forename: D J
authors.initials: DJ
authors.lastname: Triggle
mesh_terms: D000818:Animals; D006801:Humans; D007473:Ion Channels / Q000187:drug effects*; D011955:Receptors, Drug / Q000187:drug effects; D013237:Stereoisomerism
chemical_list: D007473:Ion Channels; D011955:Receptors, Drug