Microorganism-induced or enhanced mediator release: a possible mechanism in organic dust related diseases.
Bacteria were found to trigger mediator release, including histamine, leukotriene B4, and prostaglandin D2. Furthermore, histamine release caused by allergens as well as by nonimmunological reactions was enhanced by bacteria, endotoxins, and spores from molds. Mediator release and its enhancement play a crucial role for bronchoconstriction and inflammatory events in the airways. These effects of allergens, microorganisms, and other noxious agents in dusts may, therefore, in concert be responsible for the symptoms in organic dust related diseases.
Norn
S
S
Department of Pharmacology, University of Copenhagen, Panum Institute, Denmark.
D000391:Air Microbiology; D004391:Dust / Q000009:adverse effects*; D004781:Environmental Exposure / Q000009:adverse effects*; D006636:Histamine Release / Q000502:physiology*; D006801:Humans; D006967:Hypersensitivity / Q000209:etiology / Q000503:physiopathology*; D008171:Lung Diseases / Q000209:etiology / Q000503:physiopathology*
D004391:Dust