Tissue repair: a critical determinant in CCl4 hepatotoxicity.
A single antimitotic dose of colchicine administered 24 hr after a single ip dose of CCl4 profoundly enhanced lethality in the adult Sprague-Dawley male rat from < 10% to over > or = 70% within the next 24 hr. These findings suggest that disruption of normal hepatic cellular repair processes is a critical factor affecting the outcome of CCl4 intoxication.
Calabrese
E J
EJ
School of Public Health, University of Massachusetts, Amherst 01003.
Leonard
D A
DA
Baldwin
L A
LA
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D003078:Colchicine / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D003078:Colchicine