Effect of lindane on phosphatidylinositol synthesis by cerebral cortex after acute and subchronic treatment.
1. The incorporation of myo-[2-3H]inositol into phosphatidylinositols was unmodified in brain cortex miniprisms from convulsant rats. 2. However, the incorporation had increased by 300-400% in non convulsant rats which had received the same amount of lindane at a lower concentration. 3. This result suggests that phosphatidylinositols are implicated in the convulsion syndrome. 4. Experiments with lindane added in vitro were performed with both subchronically lindane intoxicated and untreated rats. 5. The results show an interesting lack of parallelism. 6. This might indicate the development of some resistance to the effects of lindane, possibly as the result of complex compensatory changes in inositol lipid biosynthesis.
del Hoyo
N
N
Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá, Madrid, Spain.
Pulido
J A
JA
Pérez-Albarsanz
M A
MA
D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D003292:Convulsants / Q000494:pharmacology; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D008297:Male; D010716:Phosphatidylinositols / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D003292:Convulsants; D010716:Phosphatidylinositols; D001556:Hexachlorocyclohexane