title: Non-sensitizing epicutaneous skin tests prevent subsequent induction of immune tolerance.
abstract: Oral administration of nickel or chromium to naive guinea pigs results in immune unresponsiveness to subsequent induction of allergic contact hypersensitivity. Such "oral tolerance" depends on the oral dose, is antigen specific, T-suppressor-cell mediated, and very persistent. In contrast, oral antigen administration to sensitized animals results at best in transient desensitization. Here we report that even non-sensitizing epicutaneous skin contacts prevented the subsequent induction of oral tolerance. These data support the view that primed T cells are less sensitive to suppressor T-cell function than naive T cells.
authors.affiliation: Department of Pathology, Vrije Universiteit, Amsterdam, The Netherlands.
authors.forename: I M
authors.initials: IM
authors.lastname: van Hoogstraten
authors.forename: B M
authors.initials: BM
authors.lastname: von Blomberg
authors.forename: D
authors.initials: D
authors.lastname: Boden
authors.forename: G
authors.initials: G
authors.lastname: Kraal
authors.forename: R J
authors.initials: RJ
authors.lastname: Scheper
mesh_terms: D000284:Administration, Oral; D000287:Administration, Topical; D000485:Allergens / Q000008:administration & dosage / Q000009:adverse effects; D000818:Animals; D002857:Chromium / Q000008:administration & dosage / Q000009:adverse effects; D017449:Dermatitis, Allergic Contact / Q000209:etiology / Q000276:immunology / Q000473:pathology; D003877:Dermatitis, Contact / Q000209:etiology; D004817:Epidermis / Q000276:immunology* / Q000473:pathology; D000939:Epitopes; D005260:Female; D006168:Guinea Pigs; D007108:Immune Tolerance / Q000276:immunology*; D009532:Nickel / Q000008:administration & dosage / Q000009:adverse effects; D012882:Skin Tests; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology / Q000502:physiology
chemical_list: D000485:Allergens; D000939:Epitopes; D002857:Chromium; D009532:Nickel