[The importance and limits of laboratory tests for evaluating the transplacental passage of fetal erythrocytes into the maternal circulation].
The KBB acid elution test is used to assess the presence and extent of transplacental passage of fetal cells into the maternal circulation both as a diagnostic aid in detecting hemorrhage before birth and in monitoring pregnancies at risk for hemolytic disease of the newborn. However the technique is ineffective when an hereditary Hb-pathy with associated increase in HbF is present in the mother, like the HPFH, delta-beta thalassemia and other hereditary abnormal hemoglobins. A mother with HPFH and another mother with delta-beta thalassemia with false positive result of the acid-elution test are described and the need for an extension of the clinical and laboratory study in families with hereditary HbF disorder is stressed.
Levi D'Ancona
R
R
Clinica Ostetrica e Ginecologica, Istituto per l'Infanzia Burlo Garofolo, Trieste.
Ricci
G
G
Alberico
S
S
Pregazzi
R
R
Maso
G
G
Molaro
G L
GL
D000328:Adult; D003937:Diagnosis, Differential; D004912:Erythrocytes / Q000737:chemistry*; D005189:False Positive Reactions; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D005331:Fetomaternal Transfusion / Q000097:blood / Q000175:diagnosis*; D006403:Hematologic Tests / Q000379:methods; D006801:Humans; D011247:Pregnancy; D012680:Sensitivity and Specificity; D017086:beta-Thalassemia / Q000175:diagnosis
D005319:Fetal Hemoglobin