[Immunological mechanisms of the formation of ecologically-induced pathology].
The paper provides the results of examining about 3,000 industrial workers exposed to various xenobiotics. Various phases of immune responses were noted in 40-60% of persons with nonspecific chronic pulmonary, gastrointestinal, gynecological diseases at remission. 10-20% of the industrial workers under study were diagnosed as having secondary immunodeficiency whose criteria were the presence of one of clinical syndromes, a sharply significant reduction in immunoglobulins, normal levels of circulating immune complexes and normal values of the lymphocytic enzymes alpha-glycerophosphate dehydrogenase, succinate dehydrogenase, lactate dehydrogenase. The stimulation of the immune system in clinically healthy individuals who have a service length of 3 year or more should be regarded as development of an immune response to a xenobiotic or its metabolites.
Trufakin
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VA
Trunova
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LA
D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000139:chemically induced; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000276:immunology*; D016273:Occupational Exposure / Q000009:adverse effects; D015262:Xenobiotics / Q000009:adverse effects*
D000936:Antigen-Antibody Complex; D007136:Immunoglobulins; D015262:Xenobiotics