Influence of anti-inflammatory treatments on experimental infection of rats with Fasciola hepatica: changes in serum levels of inflammatory markers during the early stages of fasciolosis.
Anti-inflammatory treatments with dexamethasone, indomethacin or aspirin shortly before or immediately after the experimental infection of rats with Fasciola hepatica resulted in an increase in the rats' burden of adult flukes, suggesting that the inflammatory system played an active part in the rats' immune defense against invasive F hepatica. An anti-parasitic effect of cyclosporin A on F hepatica infection in rats was also demonstrated. A weekly study of various inflammatory markers (acute phase proteins, leucocytes and platelets) demonstrated that no inflammatory reaction had occurred after the first two weeks of infection, but that there was a significant increase in acute phase proteins after three and four weeks. These increases indicated that a chronic inflammatory reaction, associated with liver damage and an increasing eosinophilia, had occurred.
Baeza
E
E
Institut National de la Recherche Agronomique, Centre de Tours, Laboratoire d'Immunopathologie des Maladies Parasitaires, Nouzilly, France.
Poitou
I
I
Delers
F
F
Boulard
C
C
D000209:Acute-Phase Proteins / Q000032:analysis; D000704:Analysis of Variance; D000818:Animals; D000909:Antibodies, Helminth / Q000097:blood; D000917:Antibody Formation; D000947:Antigens, Helminth / Q000276:immunology; D001241:Aspirin / Q000627:therapeutic use*; D015415:Biomarkers / Q000097:blood; D003176:Complement C3 / Q000032:analysis; D016572:Cyclosporine / Q000627:therapeutic use; D003907:Dexamethasone / Q000627:therapeutic use*; D005210:Fasciola hepatica; D005211:Fascioliasis / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D007213:Indomethacin / Q000627:therapeutic use*; D007249:Inflammation; D007958:Leukocyte Count; D008297:Male; D010976:Platelet Count; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D000209:Acute-Phase Proteins; D000909:Antibodies, Helminth; D000947:Antigens, Helminth; D015415:Biomarkers; D003176:Complement C3; D003907:Dexamethasone; D016572:Cyclosporine; D005340:Fibrinogen; D001241:Aspirin; D007213:Indomethacin