title: The effect of exercise and zinc supplement on the hematological parameters in rats.
abstract: This study evaluates the consequences of a session of intensive short-duration exercise and Zn supplementation on different hematological variables. Forty male Wistar rats were divided into four groups (n = 10): the first nonsupplemented, maintained at rest (R); the second nonsupplemented, undergoing exercise (E); the third supplemented with Zn, kept at rest (ZnR); and the fourth supplemented with Zn, undergoing exercise (ZnE). Zinc supplements (200 ppm) were given in drinking water. The exercise consisted of a single session of swimming until exhaustion. At rest, RBC, Hb, and Hto fell (p < 0.05), whereas red cell indices, MCV, and MCH rose (p < 0.05) in +ZnR compared with R; MCHC remained unchanged (ZnR vs R). After exercise, RBC, Hb, and Hto increased significantly in E and in ZnE compared with R and ZnR, respectively. In addition, RBC and Hb were lower (p < 0.01) in ZnE compared with E; however, MCV and MCH were higher (p < 0.05) in the group ZnE vs E. With respect to white blood cells--leukocytes (WBC), lymphocytes (LYMPH), and neutrophils (NEUT)--no significant differences were observed between groups at rest (ZnR vs R). WBC and LYMPH increased significantly in E with respect to the rest situation (E vs R), but this did not happen in supplemented animals (ZnE vs ZnR). Level of pH decreased after exercise both in E and in ZnE, but the fall was lower in the latter. We believe that a single session of swimming until exhaustion leads to an increase in RBC, Hb, and Hto without causing changes in MCV, MCH, and MCHC.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Physiology and Biochemistry, University of Valladolid, School of Physiotherapy, Soria, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Cordova
authors.forename: F J
authors.initials: FJ
authors.lastname: Navas
authors.forename: J F
authors.initials: JF
authors.lastname: Escanero
mesh_terms: D000138:Acidosis / Q000209:etiology / Q000517:prevention & control; D000818:Animals; D001773:Blood Cells / Q000187:drug effects*; D004912:Erythrocytes / Q000187:drug effects; D008297:Male; D010805:Physical Conditioning, Animal; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000494:pharmacology*
chemical_list: D015032:Zinc