[Leukocyte adhesion molecules in chronic inflammatory diseases of the cornea].
Using immunohistochemical techniques, we investigated the expression of leukocyte adhesion molecules-intercellular adhesion molecule-1 (ICAM-1), E-selectin (endothelial leukocyte adhesion molecule-1), and vascular cell adhesion molecule-1 (VCAM-1)--in various chronic inflammatory corneal diseases of different etiology. ICAM-1 was focally expressed on epithelial cells and showed an increased expression, on keratocytes, corneal endothelial cells, and vascular endothelial cells. E-selectin was present on vascular endothelial cells of several corneas, while VCAM-1 was found particularly on macrophages and only sporadically on vascular endothelial cells. Our results suggest that ICAM-1, E-selectin, and VCAM-1 may be involved in the pathogenesis of various chronic inflammatory corneal diseases, particularly in the selective recruitment of different leukocyte populations.
Philipp
W
W
Abteilung für Ophthalmologie, Universität Innsbruck, Osterreich.
Göttinger
W
W
D000328:Adult; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002908:Chronic Disease; D003315:Cornea / Q000378:metabolism / Q000473:pathology; D019040:E-Selectin; D006684:HLA-DR Antigens / Q000378:metabolism; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007634:Keratitis / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D019010:Vascular Cell Adhesion Molecule-1
D015815:Cell Adhesion Molecules; D019040:E-Selectin; D006684:HLA-DR Antigens; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1