title: Autopsy report of acute necrotizing opticomyelopathy associated with thyroid cancer.
abstract: We report an autopsied case of paraneoplastic necrotizing myelopathy. The patient had bilateral blindness, quadriplegia, and dyspnea of acute onset and died without remission 7 weeks later. The severe tissue necrosis and demyelination were found in the optic chiasm and from the medulla oblongata throughout the whole length of spinal cord. A papillary carcinoma was found in the thyroid gland at autopsy. In the present case IgG, myelin basic protein and activated helper T cells were increased in the CSF at onset, suggesting a mechanism of autoimmune demyelination for the condition.
authors.affiliation: Department of Internal Medicine, Saga Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kuroda
authors.forename: M
authors.initials: M
authors.lastname: Miyahara
authors.forename: T
authors.initials: T
authors.lastname: Sakemi
authors.forename: M
authors.initials: M
authors.lastname: Matsui
authors.forename: T
authors.initials: T
authors.lastname: Ryu
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
authors.forename: E
authors.initials: E
authors.lastname: Sasadomi
authors.forename: H
authors.initials: H
authors.lastname: Sugihara
mesh_terms: D001327:Autoimmune Diseases / Q000473:pathology; D001344:Autopsy; D002291:Carcinoma, Papillary / Q000473:pathology*; D003711:Demyelinating Diseases / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D008526:Medulla Oblongata / Q000473:pathology*; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid; D009336:Necrosis; D009897:Optic Chiasm / Q000473:pathology*; D010257:Paraneoplastic Syndromes / Q000134:cerebrospinal fluid / Q000473:pathology*; D013116:Spinal Cord / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000134:cerebrospinal fluid / Q000473:pathology*
chemical_list: D007074:Immunoglobulin G; D004676:Myelin Basic Protein