Suppression of in vivo tumor-induced angiogenesis by the protein-bound polysaccharide PSK.
The anti-angiogenic effects of an antitumor protein-bound polysaccharide, PSK, obtained from cultured mycelia of Coriolus versicolor in basidiomycetes were examined by the mouse dorsal air sac assay. PSK suppressed the mouse hepatoma MH134-induced angiogenesis when assessed by morphological and biochemical examinations. This finding suggested that the anti-metastatic effect of PSK is attributed to the suppression of tumor-induced angiogenesis.
Kanoh
T
T
Kureha Chemical Ind. Co., Ltd., Biomedical Research Laboratories, Tokyo, Japan.
Matsunaga
K
K
Saito
K
K
Fujii
T
T
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D008114:Liver Neoplasms, Experimental / Q000098:blood supply* / Q000188:drug therapy; D051379:Mice; D008809:Mice, Inbred C3H; D008813:Mice, Inbred ICR; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D011509:Proteoglycans / Q000494:pharmacology*
D000903:Antibiotics, Antineoplastic; D011509:Proteoglycans; C010770:polysaccharide-K