Mutagenicity of 1,3-butadiene inhalation in somatic and germinal cells of mice.
Inhalation exposure of mice to 50, 200, 500 or 1300 ppm of 1,3-butadiene for 6 h per day for 5 consecutive days caused micronuclei in mouse bone marrow and peripheral blood erythrocytes. The dose response was non-linear. The slope of the curve flattened with increasing exposure concentration. Coat color spots were found in the mouse spot test after exposure of pregnant females on pregnancy days 8-12 to 500 ppm of 1,3-butadiene. Dominant lethal mutations were induced in spermatozoa and late spermatids after exposure of male mice to 1300 ppm with the 5-day exposure regimen. Thus, in the mouse 1,3-butadiene is a somatic and germ cell mutagen.
Adler
I D
ID
Institut für Säugetiergenetik, GSF-Forschungszentrum für Umwelt und Gesundheit GmbH, Oberschleissheim, Germany.
Cao
J
J
Filser
J G
JG
Gassner
P
P
Kessler
W
W
Kliesch
U
U
Neuhäuser-Klaus
A
A
Nüsse
M
M
D000280:Administration, Inhalation; D000818:Animals; D001853:Bone Marrow / Q000187:drug effects* / Q000473:pathology; D001854:Bone Marrow Cells; D002070:Butadienes / Q000008:administration & dosage / Q000633:toxicity*; D003433:Crosses, Genetic; D004305:Dose-Response Relationship, Drug; D004912:Erythrocytes / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D005260:Female; D005434:Flow Cytometry; D005799:Genes, Dominant; D005804:Genes, Lethal; D005854:Germ Cells / Q000187:drug effects*; D006200:Hair Color; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000187:drug effects*; D012737:Sex Factors
D002070:Butadienes; D009153:Mutagens; C031763:1,3-butadiene