title: Chromophobe renal cell carcinoma: a report of two cases.
abstract: Chromophobe renal cell carcinoma (RCC) is a recently established subtype of RCC, which has rarely been reported in Japan. In this communication, the authors report two Japanese cases of chromophobe RCC together with the immunohistochemical findings. The tumors were composed of sheets and cribriform glands formed by tumor cells with cloudy and reticular cytoplasm. Ultrastructurally, the cytoplasm was filled with numerous microvesicles. The tumor cells were positive for cytokeratin, epithelial membrane antigen, and Tamm-Horsfall protein. Occasionally, LeuM1-positive cells were also noted. Vimentin was negative, unlike the usual RCC. Reactivity for peanut agglutinin was more frequent than that to Lotus tetragonolobus agglutinin. The results of this study suggest that the tumor cells possessed phenotypes similar to the distal nephron rather than to the proximal tubular cells.
authors.affiliation: Department of Pathology, Yokohama City University, School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Fukushima
authors.forename: Y
authors.initials: Y
authors.lastname: Nagashima
authors.forename: Y
authors.initials: Y
authors.lastname: Nakatani
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Fukasawa
authors.forename: Y
authors.initials: Y
authors.lastname: Satomi
authors.forename: K
authors.initials: K
authors.lastname: Yu
authors.forename: Y
authors.initials: Y
authors.lastname: Miyagi
authors.forename: I
authors.initials: I
authors.lastname: Aoki
authors.forename: K
authors.initials: K
authors.lastname: Misugi
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D002292:Carcinoma, Renal Cell / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D007680:Kidney Neoplasms / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D037102:Lectins / Q000737:chemistry; D016256:Lewis X Antigen; D014746:Vimentin / Q000032:analysis
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D037102:Lectins; D016256:Lewis X Antigen; D014746:Vimentin; D007633:Keratins