title: The fastest genome evolution ever described: HIV variation in situ.
abstract: Human immunodeficiency virus is an RNA virus in which the degree of genetic variation observed is phenomenal--up to 20% within an infected individual. This is essentially due to remorseless cycles of viral replication, most probably due to chronic activation of the immune system. It can be estimated that the number of variants in existence worldwide must be in excess of 10(14)-10(18), and given the nature of RNA viruses even more novel variants should emerge.
authors.affiliation: Unité de Rétrovirologie Moléculaire, Institut Pasteur, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Wain-Hobson
mesh_terms: D005075:Biological Evolution; D014644:Genetic Variation; D016679:Genome, Viral; D006678:HIV / Q000235:genetics* / Q000502:physiology; D015658:HIV Infections / Q000382:microbiology; D006801:Humans; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D013997:Time Factors
chemical_list: D012194:RNA-Directed DNA Polymerase