Topical capsaicin-pharmacology and potential role in the treatment of temporomandibular pain.
Capsaicin is an over-the-counter topical analgesic marketed at 0.025% and 0.075% concentrations. It is currently approved by the United States Food and Drug Administration for the topical relief of pain due to rheumatoid arthritis, osteoarthritis and various neuralgias. This paper will review the basic and clinical pharmacology of capsaicin, and discuss its potential role in the management of pain in the temporomandibular joint region.
Hersh
E V
EV
Department of Oral and Maxillofacial Surgery/Pharmacology, University of Pennsylvania School of Dental Medicine, Philadelphia.
Pertes
R A
RA
Ochs
H A
HA
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D002211:Capsaicin / Q000494:pharmacology* / Q000627:therapeutic use*; D002908:Chronic Disease; D005157:Facial Pain / Q000188:drug therapy*; D006801:Humans; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology; D013373:Substance P / Q000037:antagonists & inhibitors / Q000502:physiology; D013705:Temporomandibular Joint Disorders / Q000188:drug therapy*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013373:Substance P; D002211:Capsaicin