Nitric oxide (NO) synthase inhibitors abolish cocaine-induced toxicity in mice.
Repeated administration of cocaine (45 mg/kg/day) for 7 days to Swiss-Webster mice resulted in a progressive increase in the convulsive response to cocaine and augmentation in lethality rate. Pretreatment with the nitric oxide (NO) synthase inhibitors, L-NAME (100 mg/kg/day) or NO-Arg (25 mg/kg/day), prior to cocaine administration completely abolished the sensitization to the convulsive and lethal responses to cocaine. These findings suggest a role for NO in cocaine-induced toxicity.
Itzhak
Y
Y
Department of Biochemistry and Molecular Biology, University of Miami School of Medicine, FL 33101.
D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D003042:Cocaine / Q000037:antagonists & inhibitors* / Q000633:toxicity; D016291:Dizocilpine Maleate / Q000494:pharmacology; D008297:Male; D051379:Mice; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000037:antagonists & inhibitors*; D019001:Nitric Oxide Synthase; D019335:Nitroarginine; D017478:Receptors, Phencyclidine / Q000187:drug effects; D012640:Seizures / Q000139:chemically induced
D017478:Receptors, Phencyclidine; D019335:Nitroarginine; D009569:Nitric Oxide; D016291:Dizocilpine Maleate; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D003042:Cocaine; D019331:NG-Nitroarginine Methyl Ester