title: Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis.
abstract: The receptor for macrophage colony stimulating factor (CSF-1) was localized immunohistochemically in postmortem human brain tissue. Microglia constitutively expressed the receptor for CSF-1 and its expression was upregulated in lesions of Alzheimer's disease and amyotrophic lateral sclerosis. The CSF-1 mediated pathway appears to be involved in the response and activation of microglia in the central nervous system lesions.
authors.affiliation: Tokyo Institute of Psychiatry, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Akiyama
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
authors.forename: H
authors.initials: H
authors.lastname: Kondo
authors.forename: K
authors.initials: K
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: P L
authors.initials: PL
authors.lastname: McGeer
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002102:Cadaver; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D017628:Microglia / Q000378:metabolism*; D008875:Middle Aged; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D013194:Staining and Labeling; D015854:Up-Regulation
chemical_list: D016186:Receptor, Macrophage Colony-Stimulating Factor