title: Structural similarities between myelin and hydrophobic surfactant associated proteins: protein motifs for interacting with bilayers.
abstract: A group of predicted structural similarities exist between the hydrophobic pulmonary surfactant protein SP-B and SP-C and the hydrophobic proteins of myelin, either the myelin basic protein and the proteolipid protein of central nervous system myelin, or the P0 protein of peripheral myelin. These similarities include, among other factors, the charge density, post-translational modification by fatty acids, some potential periodicity in primary structure and an overall hydrophobicity. The similarities suggest that these proteins might have similar means of interacting with each other and with lipid bilayers in their respective biological systems.
authors.affiliation: Departamento de Bioquímica, Facultad de Ciencias Biologicas, Universidad Complutense, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Pérez-Gil
authors.forename: K M
authors.initials: KM
authors.lastname: Keogh
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002417:Cattle; D004285:Dogs; D006801:Humans; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000737:chemistry; D009185:Myelin Proteins / Q000737:chemistry*; D018991:Myelin Proteolipid Protein; D017433:Protein Structure, Secondary; D011510:Proteolipids / Q000737:chemistry; D011663:Pulmonary Surfactants / Q000737:chemistry*; D011817:Rabbits; D051381:Rats; D013045:Species Specificity; D013329:Structure-Activity Relationship; D013552:Swine; D014867:Water
chemical_list: D004676:Myelin Basic Protein; D009185:Myelin Proteins; D018991:Myelin Proteolipid Protein; D011510:Proteolipids; D011663:Pulmonary Surfactants; D014867:Water