title: Selective loss of NADPH-diaphorase-containing neurons in the dentate gyrus following transient ischemia.
abstract: The effect of transient forebrain ischemia on NADPH-diaphorase-containing neurons was examined in the dentate gyrus of the gerbil. NADPH-diaphorase histochemistry was performed in animals subjected to temporary occlusion of the common carotid arteries and sham-operated animals. Seven days following transient ischemia, the number of NADPH-diaphorase-positive neurons in the infragranular zone of the dentate gyrus was reduced by approximately 50% compared with control animals. Since neighboring granule cells are known to be resistant to this level of ischemic challenge, the present observations indicate that NADPH-diaphorase-containing neurons in the dentate gyrus are selectively vulnerable to brief ischemia.
authors.affiliation: Department of Neurological Surgery, University of Virginia, Charlottesville 22908.
authors.forename: S C
authors.initials: SC
authors.lastname: Hong
authors.forename: G
authors.initials: G
authors.lastname: Lanzino
authors.forename: J
authors.initials: J
authors.lastname: Collins
authors.forename: N F
authors.initials: NF
authors.lastname: Kassell
authors.forename: K S
authors.initials: KS
authors.lastname: Lee
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000032:analysis; D000818:Animals; D005849:Gerbillinae; D006624:Hippocampus / Q000201:enzymology / Q000473:pathology*; D002546:Ischemic Attack, Transient / Q000201:enzymology / Q000473:pathology*; D009252:NADPH Dehydrogenase / Q000032:analysis*; D009474:Neurons / Q000201:enzymology / Q000473:pathology*; D019001:Nitric Oxide Synthase; D016548:Prosencephalon
chemical_list: D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D009252:NADPH Dehydrogenase