title: A multicentre double-blind investigation comparing nimesulide and naproxen in the treatment of minor sport injuries.
abstract: A total of 660 patients with minor traumatic sport-related lesions of soft tissues were recruited to a randomised double-blind 7-day study to evaluate the efficacy and the tolerability of oral nimesulide (300 mg/day) in comparison with naproxen (750 mg/day). Both drugs were similarly effective in reducing the degree of oedema and intensity of pain, with most patients experiencing remission, which allowed resumption of regular sporting activities. Both drugs were generally well tolerated, although gastrointestinal intolerance was more frequently associated with naproxen therapy.
authors.affiliation: Associazione Nazionale dei Medici Specialisti in Medicina dello Sport, Università di Chieti, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Calligaris
authors.forename: I
authors.initials: I
authors.lastname: Scaricabarozzi
authors.forename: L
authors.initials: L
authors.lastname: Vecchiet
mesh_terms: D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001265:Athletic Injuries / Q000188:drug therapy*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009288:Naproxen / Q000627:therapeutic use*; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D009288:Naproxen; C012655:nimesulide