p-Chlorophenylalanine damages pancreatic acinar cell of the chicken.
1. Birds were injected intraperitoneally with DL-p-chlorophenylalanine (p-CP), which is an inhibitor of phenylalanine hydroxylase, or saline one day before the experiment. The weight and cell size of pancreas increased by the p-CP treatment. 2. The application of acetylcholine (5.50 x 10(-9) to 5.50 x 10(-5) M) caused a dose dependent increase in amylase release from the superfused segment of pancreas, although the response significantly decreased in the pancreatic segment treated with p-CP, compared with the control.
Furuse
M
M
Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan.
Satoh
S
S
Yang
S I
SI
Watanabe
T
T
Okumura
J
J
D000109:Acetylcholine / Q000494:pharmacology; D000681:Amylases / Q000378:metabolism; D000818:Animals; D002645:Chickens; D010134:Fenclonine / Q000494:pharmacology*; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010179:Pancreas / Q000166:cytology* / Q000187:drug effects / Q000201:enzymology
D000681:Amylases; D000109:Acetylcholine; D010134:Fenclonine