title: Trisomy 2, trisomy 20, and del(17p) as sole chromosomal abnormalities in three cases of hepatoblastoma.
abstract: Short-term cultures of three hepatoblastomas were analyzed cytogenetically. Trisomy 2, trisomy 20, and a deletion of 17p were found as the sole abnormalities, yielding the karyotypes 47,XY, + 2; 47,XX, + 20; and 46,XX,del(17)(p12)/46,XX. This is the first reported case of deletion of 17p as the sole chromosomal abnormality in a hepatoblastoma and the first reported case of trisomy 20 without double minute chromosomes as a sole chromosomal abnormality in hepatoblastoma.
authors.affiliation: Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072.
authors.forename: V S
authors.initials: VS
authors.lastname: Tonk
authors.forename: K S
authors.initials: KS
authors.lastname: Wilson
authors.forename: C F
authors.initials: CF
authors.lastname: Timmons
authors.forename: N R
authors.initials: NR
authors.lastname: Schneider
mesh_terms: D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D002889:Chromosomes, Human, Pair 2; D002890:Chromosomes, Human, Pair 20; D005260:Female; D018197:Hepatoblastoma / Q000235:genetics*; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D014314:Trisomy / Q000235:genetics*