Effect of cyclosporin and the prostacyclin analogue iloprost on human glomerular vasoreactivity.
Cyclosporin is known to cause a decrease in renal blood flow and glomerular filtration rate in both humans and animals. These acute modifications are reversible if the drug is withdrawn, and seem to be caused by a local hormonal imbalance between vasoconstricting and vasodilating substances. We studied human glomeruli incubated with either CsA alone, iloprost alone, or CsA + iloprost. Photomicrographs of glomeruli were taken at t0, t1, t2 and t5 min and glomerular areas were measured with a videoanalyser linked to a computer. Results show a significant vasoconstriction with CsA alone, and no significant modification of glomerular areas with iloprost or CsA + iloprost. We conclude that iloprost prevents CsA-induced vasoconstriction in human glomeruli in vitro.
Le Guen
E
E
Department of Nephrology and Transplantation, Hôpital Pellegrin, Bordeaux, France.
Morel
D
D
L'Azou
B
B
Cambar
J
J
Potaux
L
L
D016572:Cyclosporine / Q000633:toxicity*; D006801:Humans; D016285:Iloprost / Q000494:pharmacology*; D007678:Kidney Glomerulus / Q000098:blood supply / Q000187:drug effects*; D014661:Vasoconstriction / Q000187:drug effects*
D016572:Cyclosporine; D016285:Iloprost