The importance of the clinico-pathological presentations in the evaluation of the survival of patients with IgA nephropathy.
The authors analyzed renal biopsy specimens, clinical data (erythruria/hematuria, severity of proteinuria, occurrence of hypertension and renal failure) and survival (using the original method by Cutler and Ederer) in 60 patients with IgA nephropathy, 34 were male and 26 female aged between 15 and 56 years (32.8 +/- 9.1). The authors divided all cases in 5 classes taking into consideration glomerular changes: class 1 disease-minimal lesions, class 2-minor changes, classes 3-focal and segmental lesions, class 4-diffuse proliferation and class 5 disease-diffuse sclerotic changes. The authors found that: class 1 was younger than the others; macroscopic hematuria was more frequent in classes 1 and 2; proteinuria was significantly higher in classes and 3; and hypertension was absent in class 1 correlating with the severity of glomerular changes. Development of chronic renal failure and occurrence of kidney death also correlated directly with the severity of histologic glomerular classes.
Polenaković
M
M
Department of Nephrology, Faculty of Medicine, Skopje, Macedonia.
Grcevska
L
L
Polenaković
H
H
Josifovska
T
T
D000293:Adolescent; D000328:Adult; D005260:Female; D005922:Glomerulonephritis, IGA / Q000401:mortality* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D015996:Survival Rate