Absolute stereostructures of hydramacrosides A and B, new bioactive secoiridoid glucoside complexes from the leaves of Hydrangea macrophylla Seringe var. thunbergii Makino.
Two new bioactive secoiridoid glucoside complexes named hydramacrosides A and B were isolated from the leaves of Hydrangea macrophylla SERINGE var. thunbergii MAKINO. The absolute stereostructures of hydramacrosides A and B were elucidated on the basis of chemical and physicochemical evidence which included the application of the 13C NMR glycosylation shift rule of 1, 1'-disaccharides and the modified Mosher's method. Hydramacrosides A and B exhibited inhibitory effect on the histamine release from rat mast cells induced by antigen-antibody reaction.
Yoshikawa
M
M
Kyoto Pharmaceutical University, Japan.
Ueda
T
T
Matsuda
H
H
Yamahara
J
J
Murakami
N
N
D000818:Animals; D000937:Antigen-Antibody Reactions; D005947:Glucose / Q000378:metabolism; D005960:Glucosides / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006031:Glycosylation; D006633:Histamine Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D039823:Iridoids; D009682:Magnetic Resonance Spectroscopy; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D010936:Plant Extracts / Q000737:chemistry; D010946:Plants, Medicinal; D011714:Pyrans / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D013237:Stereoisomerism
D005960:Glucosides; D006633:Histamine Antagonists; D039823:Iridoids; D010936:Plant Extracts; D011714:Pyrans; D005947:Glucose