Central vein occlusion study of photocoagulation. Manual of operations. Central Vein Occlusion Study Group.
This paper is the complete protocol (Manual of Operations) used in the Central Vein Occlusion Study (CVOS). The CVOS is a randomized clinical trial and natural history study of central retinal vein occlusion supported by the National Eye Institute. The administrative structure includes a Data and Safety Monitoring Board, 9 clinical centers, a coordinating center, and a photograph reading center. The Manual of Operations describes study design, organization, policies, and procedures. Procedures described in detail include measurement of visual acuity, fundus and iris photography, fluorescein angiography, and quality control.
D000328:Adult; D002985:Clinical Protocols; D015355:Glaucoma, Neovascular / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D007498:Iris / Q000098:blood supply*; D007511:Ischemia; D017075:Laser Coagulation / Q000379:methods; D008269:Macular Edema / Q000209:etiology / Q000601:surgery*; D015337:Multicenter Studies as Topic; D009389:Neovascularization, Pathologic / Q000209:etiology / Q000517:prevention & control*; D010349:Patient Compliance; D011446:Prospective Studies; D016032:Randomized Controlled Trials as Topic; D012107:Research Design; D015356:Retinal Artery Occlusion / Q000150:complications / Q000601:surgery*; D014792:Visual Acuity