Distortion in the parental transmission of HLA-A2 haplotypes (locus A,B).
The parental transmission of HLA-2 antigen in association with the epitopes BW4 and BW6 (class I HLA haplotypes locus A,B) was analyzed in sons and daughters from 42 families in which one of the parents carried the HLA-A2 antigen. When the parental transmission of A2 BW4 and A2 BW6 was compared, it was observed that a significantly higher number of siblings inherited the haplotype A2 BW4 from the paternal than from the maternal haplotype. Although the number of cases is small, the mode of inheritance of haplotype A2 BW6 was completely different. The genetic distortion in the transmission of HLA-2 BW4 and HLA-2 BW6 was observed in children of both sexes.
Komlos
L
L
B. Gattegno Research Institute of Human Reproduction and Fetal Development, Hasharon Hospital, Golda Medical Center, Petah-Tiqva, Israel.
Livni
E
E
Klein
T
T
Halbrecht
I
I
Hart
J
J
Zaizov
R
R
D003602:Cytotoxicity, Immunologic; D000939:Epitopes / Q000235:genetics; D005220:Fathers; D005260:Female; D015789:HLA-A2 Antigen / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics / Q000276:immunology; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange / Q000235:genetics / Q000276:immunology; D008957:Models, Genetic; D009035:Mothers; D011247:Pregnancy
D000939:Epitopes; D015789:HLA-A2 Antigen