title: Effects of neuropeptide Y on lung vascular permeability in the pulmonary circulation of rats.
abstract: The effects of neuropeptides on the capillary filtration coefficient in the vessels of the pulmonary circulation were examined, using isolated lung perfusion preparations from rats. Neuropeptide Y and neurokinin A elevated the filtration coefficient, and calcitonin gene related peptide diminished it. Neurotensin and substance P did not affect the value at concentrations less than 10(-7) M. The number of extravasated carbon particle deposits subsequent to tracheal application of neuropeptide Y during spontaneous respiration increased in a dose-dependent manner. From these results, we conclude that neuropeptide Y may increase vascular permeability in the pulmonary circulation.
authors.affiliation: Section of Biology, Aichi Prefectural Institute of Health, Nagoya, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Hirabayashi
authors.forename: K
authors.initials: K
authors.lastname: Nishiwaki
authors.forename: K
authors.initials: K
authors.lastname: Taki
authors.forename: Y
authors.initials: Y
authors.lastname: Shimada
authors.forename: N
authors.initials: N
authors.lastname: Ishikawa
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D008297:Male; D015288:Neurokinin A / Q000494:pharmacology; D009478:Neuropeptide Y / Q000494:pharmacology*; D009479:Neuropeptides / Q000494:pharmacology*; D009496:Neurotensin / Q000494:pharmacology; D011652:Pulmonary Circulation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013373:Substance P / Q000494:pharmacology
chemical_list: D009478:Neuropeptide Y; D009479:Neuropeptides; D013373:Substance P; D009496:Neurotensin; D015288:Neurokinin A; D015740:Calcitonin Gene-Related Peptide