title: Serum amylase determinations in pediatric patients presenting to the ED with acute abdominal pain or trauma.
abstract: The objective of this study was to evaluate the overall impact of serum amylase determinations in the initial management of patients presenting to the pediatric emergency department (ED) with the acute onset of abdominal pain or trauma. All cases of patients younger than 18 years of age who presented to the pediatric ED for whom a serum amylase value was determined during an 18-month period were reviewed. Data were collected retrospectively, including serum amylase concentration, age, gender, presenting complaint, discharge/admission status, diagnosis, and discharge plans or inpatient management to evaluate the impact of serum amylase determinations. Seven hundred twenty-three cases were reviewed during the study period. Six hundred fifty-six patients met study criteria, with 385 serum amylase determinations performed for the evaluation of acute abdominal pain and 271 for acute trauma. Sixty-seven serum amylase determinations were also sent for other reasons. Overall, 12 of 656 study patients had elevated amylase levels (1.8%) during the study period (range, 130 to 2318 U/L). Eight of 271 amylase levels sent to the laboratory for trauma (3.0%), and 4 of 385 sent for abdominal pain (1.0%) were elevated. Overall, serum amylase concentration had no influence on whether or not the patient was admitted to the hospital. Of the 12 patients with elevated amylase levels sent for abdominal pain or trauma, only 2 had their clinical management affected by the serum amylase concentration. In both cases, the patient presented with subacute abdominal pain related to significant abdominal trauma that had occurred 2 to 3 weeks earlier. Both patients showed evidence of pancreatic insult with diagnostic imaging studies.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pediatrics, Rhode Island Hospital, Brown University, Providence 02903.
authors.forename: H K
authors.initials: HK
authors.lastname: Simon
authors.forename: A
authors.initials: A
authors.lastname: Muehlberg
authors.forename: J G
authors.initials: JG
authors.lastname: Linakis
mesh_terms: D000007:Abdominal Injuries / Q000201:enzymology*; D015746:Abdominal Pain / Q000201:enzymology*; D000059:Accidents; D000208:Acute Disease; D000293:Adolescent; D000681:Amylases / Q000097:blood*; D002648:Child; D004630:Emergencies; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009104:Multiple Trauma / Q000175:diagnosis / Q000201:enzymology; D010195:Pancreatitis / Q000175:diagnosis / Q000201:enzymology*; D012189:Retrospective Studies; D014949:Wounds, Nonpenetrating / Q000201:enzymology*
chemical_list: D000681:Amylases