Multiple pulmonary nodules manifested in a patient with NK cell granular lymphocyte proliferative disorder.
An 18-year-old man was admitted to our hospital with high temperature and dyspnea. A chest radiograph revealed the presence of multiple round nodules compatible with a metastatic lung cancer. The peripheral white blood cell count was 22,000/mm3 and more than 85 percent were atypical large lymphocytes with azurophilic granules. He was diagnosed as having natural killer (NK)-cell granular lymphocyte proliferative disorder (NK-GLPD) as the lymphocytes were positive with CD56, a cell surface marker characteristic for NK cells. The major pathologic finding of the tissue collected from the pulmonary nodules by transbronchial lung biopsy was infiltration of mostly large granular lymphocytes.
Furuno
T
T
Research Institute for the Diseases of the Chest, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Hara
N
N
Hagimoto
N
N
Mori
N
N
Muranishi
H
H
D000293:Adolescent; D015703:Antigens, CD / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D019002:CD56 Antigen; D002455:Cell Division; D004854:Herpesvirus 4, Human / Q000276:immunology; D006801:Humans; D007244:Infectious Mononucleosis / Q000175:diagnosis; D007694:Killer Cells, Natural / Q000276:immunology* / Q000473:pathology; D008168:Lung / Q000276:immunology / Q000473:pathology*; D008171:Lung Diseases / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D008232:Lymphoproliferative Disorders / Q000000981:diagnostic imaging / Q000276:immunology / Q000473:pathology*; D008297:Male; D011859:Radiography
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D019002:CD56 Antigen