title: [Nocturnal ventricular arrhythmia in patients with sleep apnea and suspected coronary heart disease].
abstract: BACKGROUND
  Patients with sleep apnea and nocturnal brady- and tachyarrhythmia are considered to be patients at especially high risk within the group of all apnea patients.
  
  
  METHODS
  13 patients with sleep apnea (apnea-index > 10 events/h), suspected coronary heart disease and known increased frequency of nocturnal premature ventricular contractions (PVC) were studied. Polysomnography, long-term ECG and six-lead ECG were performed.
  
  
  RESULTS
  Within the period studied (1.00 to 6.00 o'clock), an average of 47 PVC per hour was recorded (range 4 to 337/h). In two patients 24 episodes of nocturnal myocardial ischemia were observed, but were not accompanied by PVC. Interestingly only 387 of 1371 premature ventricular contractions (28.2%) were associated to apnea/hyperventilation episodes. Arrhythmia occurred mainly during sleep stages I/II and REM (n.s.). There was a tendency towards more frequent PVC with more pronounced oxygen desaturations.
  
  
  CONCLUSIONS
  Patients with coronary heart disease, obstructive sleep apnea and severe hyoxemia are at higher risk of developing nocturnal PVC because reduced hypoxic tolerance of the heart may lead to electrical instability.
authors.affiliation: Zentrum Innere Medizin, Medizinische Poliklinik, Philipps-Universität, Marburg.
authors.forename: U
authors.initials: U
authors.lastname: Koehler
authors.forename: T
authors.initials: T
authors.lastname: Glaremin
authors.forename: W
authors.initials: W
authors.lastname: Cassel
authors.forename: M
authors.initials: M
authors.lastname: Feuring
authors.forename: T
authors.initials: T
authors.lastname: Pomykaj
authors.forename: H
authors.initials: H
authors.lastname: Schäfer
authors.forename: M
authors.initials: M
authors.lastname: Stellwaag
mesh_terms: D001919:Bradycardia / Q000503:physiopathology*; D005117:Cardiac Complexes, Premature / Q000503:physiopathology; D002940:Circadian Rhythm / Q000502:physiology; D003327:Coronary Disease / Q000503:physiopathology*; D015716:Electrocardiography, Ambulatory; D005260:Female; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D012891:Sleep Apnea Syndromes / Q000503:physiopathology*; D012895:Sleep, REM / Q000502:physiology; D017180:Tachycardia, Ventricular / Q000503:physiopathology*
chemical_list: D010100:Oxygen