[Pharmacological properties of aprotinin and its therapeutic use in heart surgery].
Aprotinin (Trasylol) is a protease-specific inhibitor that has been used for over 5 years in extracorporeal circulation (ECC) during cardiac surgery. Patients treated with this inhibitor have considerably less postoperative bleeding, along with correspondingly lower consumption of blood products. This article reviews the history of the drug, its pharmacokinetics and pharmacodynamics, its usefulness in biological sciences and its clinical application in cardiac surgery, as well as drug interactions and side effects.
Carrera
A
A
Servicio de Anestesiología y Reanimación, Clínica Puerta de Hierro, Madrid.
Fernández
P
P
García del Valle
S
S
de la Quintana
B
B
Martínez
M V
MV
D007611:Aprotinin / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000627:therapeutic use; D006348:Cardiac Surgical Procedures; D005112:Extracorporeal Circulation; D005342:Fibrinolysis / Q000187:drug effects; D006487:Hemostasis / Q000187:drug effects; D006801:Humans; D007249:Inflammation
D007611:Aprotinin