The fate of GPI-anchored molecules.
Glycosylphosphatidylinositol (GPI)-anchored proteins comprise a diverse class of membrane molecules. They protect cells from complement-mediated lysis, control cell to cell adhesion, activate T cells, and play a role in the etiology of slow viral diseases. Despite their functional diversity, GPI-anchored proteins are all attached to the plasma membrane by a common glycolipid anchor. We will examine one aspect of GPI-anchor metabolism, namely, the processing of the molecule after it arrives at the plasma membrane. After biosynthesis and transport to the plasma membrane, the GPI-anchored protein can be endocytosed and degraded or cleaved and released. The enzymatic machinery controlling the catabolism of GPI-anchored molecules at the plasma membrane is likely to play a central role in regulating the cell surface expression of these molecules.
Censullo
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P
Division of Immunology, New York University School of Medicine, New York 10016.
Davitz
M A
MA
D015703:Antigens, CD / Q000378:metabolism*; D018958:CD55 Antigens; D016222:Fibroblast Growth Factor 2 / Q000378:metabolism*; D006001:Glycoconjugates / Q000378:metabolism*; D017261:Glycosylphosphatidylinositols / Q000737:chemistry / Q000378:metabolism*; D019812:Heparan Sulfate Proteoglycans; D006497:Heparan Sulfate / Q000378:metabolism*; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D015394:Molecular Structure; D010739:Phospholipase D / Q000378:metabolism*; D011509:Proteoglycans / Q000378:metabolism*
D015703:Antigens, CD; D018958:CD55 Antigens; D016222:Fibroblast Growth Factor 2; D006001:Glycoconjugates; D017261:Glycosylphosphatidylinositols; D019812:Heparan Sulfate Proteoglycans; D006497:Heparan Sulfate; D008562:Membrane Glycoproteins; D010739:Phospholipase D; D011509:Proteoglycans