title: [Preoperative cytodiagnosis by needle aspiration of follicular thyroid lesions].
abstract: In the period 1989-92, 2729 F.N.A.B. were performed: 585 with an histological control were reviewed. The aim of the study was to evaluate the risk of carcinomatous occurrence in the follicular-structured smears and to suggest a new cytodiagnostic classification. Out of 398 follicular-structured smears, 188 were colloid nodules (CN), 38 thyreocytic hyperplasias without nuclear atypia (THWNA), 146 predominantly follicular lesions (PFL), 26 follicular lesions with nuclear pleomorphism (FLWNP). The last one showed a high incidence of neoplasia (69.2%) and carcinoma (46.1%); the second and the third only a difference in the incidence of benign neoplasms (32.9 vs. 15.8%), with almost the same percentage of occurrence of malignancies (2.6 vs. 2.1%). Such results suggest that a six-months dilatory strategy might be useful in simple follicular lesions (THWNA and PFL) whereas a cytological follicular pattern with nuclear pleomorphism requires a surgical treatment for the high risk of carcinomatous occurrence.
authors.affiliation: Istituto di Anatomia e Istologia patologica, Università Cattolica del S. Cuore, Roma.
authors.forename: G
authors.initials: G
authors.lastname: Fadda
authors.forename: C
authors.initials: C
authors.lastname: Rabitti
authors.forename: A
authors.initials: A
authors.lastname: Verzì
authors.forename: G
authors.initials: G
authors.lastname: Gullotta
authors.forename: M
authors.initials: M
authors.lastname: Lancia
authors.forename: A
authors.initials: A
authors.lastname: Bianchi
authors.forename: A
authors.initials: A
authors.lastname: Capelli
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis; D001707:Biopsy, Needle / Q000706:statistics & numerical data; D002277:Carcinoma / Q000175:diagnosis / Q000473:pathology; D003951:Diagnostic Errors; D005069:Evaluation Studies as Topic; D006801:Humans; D012680:Sensitivity and Specificity; D013194:Staining and Labeling; D013959:Thyroid Diseases / Q000175:diagnosis* / Q000473:pathology; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000175:diagnosis / Q000473:pathology
chemical_list: D014408:Biomarkers, Tumor