[The specific activity and immunological safety of the intranasal method of revaccination with a live measles vaccine made from the Leningrad-16 strain].
The search for alternative routes for administration of live measles vaccine is associated both with the threat of infection with human immunodeficiency virus, hepatitis B virus, and with the development of a more physiological, natural and less traumatic mode of vaccine administration. The influence of the intranasal administration on the general condition of the immune system, its immunomodulating effect (the emergence of inducer suppressors, cell response to the inactivated virus), was studied as well as the level and intensity of secretory and general humoral immunity. The studies confirmed the immunological effectiveness and safety of the intranasal administration of a live measles vaccine and suggested its advantages for revaccination against measles.
Iuminova
N V
NV
Krasnova
V P
VP
Liashenko
V A
VA
Vedunova
S L
SL
D000281:Administration, Intranasal; D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000097:blood; D000918:Antibody Specificity; D000956:Antigens, Viral / Q000276:immunology; D004306:Dose-Response Relationship, Immunologic; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007117:Immunization, Secondary / Q000009:adverse effects / Q000379:methods*; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood; D008458:Measles Vaccine / Q000008:administration & dosage / Q000009:adverse effects / Q000276:immunology*; D008459:Measles virus / Q000276:immunology; D012449:Safety; D013997:Time Factors
D000914:Antibodies, Viral; D000956:Antigens, Viral; D000939:Epitopes; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D008458:Measles Vaccine