Biased representation of immunoglobulin heavy chain variable region subgroups in chronic lymphocytic leukemia.
The distribution of three immunoglobulin heavy chain variable region gene subgroups (VH1, 3 and 5) was investigated, using the polymerase chain reaction technique, in 53 patients with chronic lymphocytic leukemia. Thirty-seven patients displayed rearrangements of one of the above three gene segments. Over-representation of the VH5 subgroup was observed relative to its small size.
Hakim
I
I
Institute of Hematology, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
Amariglio
N
N
Brok-Simoni
F
F
Grossman
Z
Z
Ramot
B
B
Ben-Bassat
I
I
Rechavi
G
G
D015703:Antigens, CD / Q000235:genetics; D001483:Base Sequence; D015982:Bias; D018956:CD5 Antigens; D004247:DNA / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain / Q000235:genetics*; D005828:Genetics, Population; D016678:Genome; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000235:genetics*; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D008214:Lymphocytes; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D013269:Stochastic Processes
D015703:Antigens, CD; D018956:CD5 Antigens; D007135:Immunoglobulin Variable Region; D004247:DNA