title: Higher environmental temperature-induced increase in body temperature: involvement of serotonin in GABA mediated interaction of opioidergic system.
abstract: Exposure (2 h) of adult male albino rats to higher environmental temperature (HET, 40 degrees C) significantly increased body temperature (BT). Administration of (a) 5-HTP (5 mg/kg, i.p.) or morphine (1 mg/kg, i.p.) or physostigmine (0.2 mg/kg, i.p.) alone significantly increased and (b) methysergide (1 mg/kg, i.p.) or naloxone (1 mg/kg, i.p.) or atropine (5 mg/kg, i.p.) reduced the BT of both normal and HET exposed rats. Further, it was observed that morphine prevented the methysergide-induced hypothermia and 5-HTP potentiated the morphine-induced hyperthermia in both normal and HET exposed conditions. Biochemical study also indicates that serotonin metabolism was increased but GABA utilization was reduced following exposure to HET.5-HTP or bicuculline-induced hyperthermia in control and HET exposed rat was potentiated with the coadministration of bicuculline and 5-HTP. The cotreatment of bicuculline with methysergide prevented the methysergide-induced attenuation of BT of heat exposed rat, rather BT was significantly enhanced indicating that inhibition of GABA system under heat exposed condition may activate the serotonergic activity. Further (a) enhancement of (i) morphine-induced hyperthermia with physostigmine (ii) physostigmine- or morphine+physostigmine-induced increase of BT with 5-HTP and (b) reduction of (i) morphine- or morphine + 5-HTP-induced hyperthermia with atropine and (ii) atropine-induced hypothermia with 5-HTP in both normal and HET exposed conditions suggest that HET exposure activates the cholinergic system through the activation of opioidergic and serotonergic system and hence increased the BT. Thus, it may be concluded that there is an involvement of serotonergic regulation in the opioidergic-cholinergic interaction via GABA system in HET-induced increase in BT.
authors.affiliation: Department of Biochemistry, University College of Science, University of Calcutta, India.
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
authors.forename: M K
authors.initials: MK
authors.lastname: Poddar
mesh_terms: D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001831:Body Temperature / Q000187:drug effects; D004723:Endorphins / Q000502:physiology*; D005968:Glutamate Decarboxylase / Q000378:metabolism; D006358:Hot Temperature; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D008784:Methysergide / Q000494:pharmacology; D009020:Morphine / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010830:Physostigmine / Q000494:pharmacology; D051381:Rats; D012701:Serotonin / Q000502:physiology*; D014364:Tryptophan / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D004723:Endorphins; D012701:Serotonin; D009270:Naloxone; D006897:Hydroxyindoleacetic Acid; D005680:gamma-Aminobutyric Acid; D009020:Morphine; D001285:Atropine; D014364:Tryptophan; D010830:Physostigmine; D006916:5-Hydroxytryptophan; D005968:Glutamate Decarboxylase; D008784:Methysergide