Action of MgSO4 differs from moricizine and verapamil on ouabain-induced ventricular tachycardia in normomagnesemic conscious dogs.
We performed a comparative study to determine whether acute administration of MgSO4, moricizine, and verapamil to conscious dogs with normal plasma magnesium levels (0.75 +/- 0.06 mM) terminates ouabain-induced ventricular tachycardia (VT). This arrhythmia is dependent on triggered activity (TA) resulting from delayed afterdepolarizations (DADs). In animals with surgically induced complete atrioventricular (AV) block, monomorphic VT was induced by programmed ventricular stimulation during continuous intravenous (i.v.) infusion of ouabain. At the moment of drug administration, VT persisted for at least 20 min, while the rate was stable for at least 5 min. A single dose of MgSO4 (100 mg/kg i.v.) abolished only VTs with cycle lengths > or = 320 ms (335 +/- 10 ms); VTs with faster cycle lengths (300 +/- 20 ms) were merely slowed, although the increase in plasma magnesium levels was considerable and comparable in both groups (3.9 +/- 1.6 and 4.8 +/- 1.9 mM). In contrast, moricizine (2 mg/kg i.v.) and verapamil (0.5-1.0 mg/kg i.v.) terminated both fast and slow VTs. The cycle length of VT ranged from 280 to 320 ms (mean 300 +/- 15 ms) for moricizine and 260-330 ms (mean 300 +/- 25 ms) for verapamil.(ABSTRACT TRUNCATED AT 250 WORDS)
Vos
M A
MA
Department of Cardiology, University of Limburg, Maastricht, The Netherlands.
Fazekas
T
T
Gorgels
A P
AP
Leunissen
J D
JD
Wellens
H J
HJ
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D004285:Dogs; D004558:Electric Stimulation; D005260:Female; D006327:Heart Block; D008275:Magnesium Deficiency / Q000503:physiopathology; D008278:Magnesium Sulfate / Q000097:blood / Q000494:pharmacology*; D008297:Male; D016293:Moricizine / Q000494:pharmacology*; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology; D010042:Ouabain / Q000037:antagonists & inhibitors* / Q000633:toxicity; D013617:Tachycardia, Supraventricular / Q000139:chemically induced / Q000503:physiopathology*; D014700:Verapamil / Q000494:pharmacology*
D009467:Neuromuscular Depolarizing Agents; D016293:Moricizine; D010042:Ouabain; D008278:Magnesium Sulfate; D014700:Verapamil