title: Two-year follow-up study of a patient with Parkinson's disease and severe motor fluctuations treated by co-grafts of adrenal medulla and peripheral nerve into bilateral caudate nuclei: case report.
abstract: We performed co-grafts of adrenal medulla and peripheral nerve into the bilateral caudate nuclei of a 43-year-old patient with advanced Parkinson's disease who showed severe daily motor fluctuations before surgery. There were no postoperative complications, and a 2-year follow-up result is presented. The patient showed a gradual and significant amelioration of the parkinsonian symptoms starting 2 weeks after transplantation. The alleviation of akinesia during "off" periods was the most apparent clinical improvement and continued for 2 years after surgery. The dosage of L-dopa/benserazide was significantly reduced after surgery compared with that before surgery. The results indicate that co-grafts of adrenal medulla with peripheral nerve may be useful for the treatment of Parkinson's disease in the long term.
authors.affiliation: Department of Neurological Surgery, Okayama University Medical School, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Date
authors.forename: S
authors.initials: S
authors.lastname: Asari
authors.forename: T
authors.initials: T
authors.lastname: Ohmoto
mesh_terms: D000203:Activities of Daily Living / Q000145:classification; D000313:Adrenal Medulla / Q000473:pathology / Q000637:transplantation*; D000328:Adult; D002421:Caudate Nucleus / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007367:Intercostal Nerves / Q000473:pathology / Q000637:transplantation*; D009048:Motor Skills / Q000502:physiology; D009416:Nerve Regeneration / Q000502:physiology; D009460:Neurologic Examination; D010300:Parkinson Disease / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D011183:Postoperative Complications / Q000503:physiopathology; D016896:Treatment Outcome