Role of chlorophyllin as an in vivo anticlastogen: protection against gamma-radiation and chemical clastogens.
Chlorophyllin was evaluated in the mouse bone marrow micronucleus test for its possible protective effects against chromosomal damage induced by gamma-radiation, cyclophosphamide, N-nitroso-N-ethylurea and urethane. Three doses of chlorophyllin (50, 100 and 200 mg/kg, b.w.) were orally administered to mice 2 h before exposure to the clastogens under investigation. The results obtained demonstrated that chlorophyllin can significantly reduce the incidence of micronucleated polychromatic erythrocytes induced by gamma-radiation (1.15 Gy) and all the three chemical clastogens. However with the exception of cyclophosphamide there was no indication of a dose response for the in vivo anticlastogenic effects of chlorophyllin.
Abraham
S K
SK
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Sarma
L
L
Kesavan
P C
PC
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002735:Chlorophyllides / Q000494:pharmacology*; D005720:Gamma Rays / Q000009:adverse effects*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009154:Mutation; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*
D016587:Antimutagenic Agents; D002735:Chlorophyllides; C007020:chlorophyllin