title: The CSF myelin basic protein: a reliable marker of actual cerebral damage in hydrocephalus.
abstract: Raised ventricular CSF myelin basic protein (MBP) concentration has been evidenced in 17 shunted hydrocephalic patients. Contemporary evaluation both from ventricular and lumbar CSF samples showed a concentration ratio of 20:1. In all cases the raised values of ventricular CSF concentration of MBP demonstrated a significant decrease after shunt operation. This preliminary report suggests that this marker is an important index of actual brain damage in hydrocephalus and could be taken in account for the indication of shunt operation.
authors.affiliation: Servizio di Medicina Nucleare, Università di Padova, Ospedale Regionale di Treviso, Italy.
authors.forename: P L
authors.initials: PL
authors.lastname: Longatti
authors.forename: G
authors.initials: G
authors.lastname: Canova
authors.forename: F
authors.initials: F
authors.lastname: Guida
authors.forename: A
authors.initials: A
authors.lastname: Carniato
authors.forename: M
authors.initials: M
authors.lastname: Moro
authors.forename: A
authors.initials: A
authors.lastname: Carteri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001925:Brain Damage, Chronic / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis*; D002675:Child, Preschool; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid* / Q000150:complications / Q000601:surgery; D007427:Intracranial Pressure; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid*; D017287:Ventriculoperitoneal Shunt
chemical_list: D015415:Biomarkers; D004676:Myelin Basic Protein