title: Disturbances in growth hormone secretion and action in adolescents with anorexia nervosa.
abstract: Women in whom anorexia nervosa develops during adolescence have failure of linear growth associated with low levels of insulin-like growth factor I (IGF-1). To investigate the pathophysiology of growth retardation in adolescents with anorexia nervosa, we measured basal growth hormone (GH), growth hormone-binding protein (GHBP), IGF-1, and insulin-like growth factor binding protein-3 (IGFBP-3) in three groups of patients: (1) 28 recently hospitalized female adolescents with anorexia nervosa, (2) 23 of the same patients after partial weight restoration, and (3) 28 healthy control subjects matched for age, sex, and pubertal stage. Fasting GH levels in group 1 did not differ significantly from those in group 3. In contrast, serum GHBP (p < 0.001), IGF-1 (p < 0.001), and IGFBP-3 (p < 0.01) were significantly lower in group 1 than in group 3. Serum GHBP and IGFBP-3 levels were positively correlated with body mass index. Serum GHBP levels were low in patients in all five pubertal stages and even in those shown to have adequate GH secretion. In group 2 (after refeeding) the serum IGF-1 concentration increased significantly and GHBP and IGFBP-3 returned to normal. We conclude that patients with anorexia nervosa have diminished GH action resulting in decreased secretion of IGF-1. The positive correlation with body mass index and the reversibility with refeeding suggest that these changes are secondary to malnutrition. Altered GH function that occurs during the years of active growth can explain the growth retardation seen in anorexia nervosa.
authors.affiliation: Department of Pediatrics, Schneider Children's Hospital of Long Island Jewish Medical Center, Albert Einstein College of Medicine, New Hyde Park, New York.
authors.forename: N H
authors.initials: NH
authors.lastname: Golden
authors.forename: P
authors.initials: P
authors.lastname: Kreitzer
authors.forename: M S
authors.initials: MS
authors.lastname: Jacobson
authors.forename: F I
authors.initials: FI
authors.lastname: Chasalow
authors.forename: J
authors.initials: J
authors.lastname: Schebendach
authors.forename: S M
authors.initials: SM
authors.lastname: Freedman
authors.forename: I R
authors.initials: IR
authors.lastname: Shenker
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology*; D001481:Basal Metabolism; D015992:Body Mass Index; D002352:Carrier Proteins / Q000097:blood; D016022:Case-Control Studies; D002648:Child; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006131:Growth Inhibitors / Q000097:blood; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D013002:Somatomedins / Q000032:analysis*
chemical_list: D002352:Carrier Proteins; D006131:Growth Inhibitors; D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; C051815:somatotropin-binding protein