Alteration by Iloprost of the vasospastic effects of endothelin-1 in rabbit cerebral vessels.
The reversal of endothelin-1 induced cerebral vasospasm with Iloprost was studied in the rabbit. Vasospasm in the basilar artery was evaluated by angiography; cerebral ischaemia by 'red-neurone-count' on light microscopy and morphological changes by electron microscopy. A potent antagonistic effect of Iloprost against ET-1 was observed in each of the parameters measured.
Keskil
I S
IS
Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Turkey.
Baykaner
M K
MK
Sencer
H
H
Ataoğlu
O
O
Ilgit
E
E
Erdoğan
B
B
Ceviker
N
N
Ercan
Z S
ZS
D000818:Animals; D001488:Basilar Artery / Q000473:pathology / Q000648:ultrastructure; D001921:Brain / Q000473:pathology / Q000648:ultrastructure; D002533:Cerebral Angiography; D016232:Endothelins / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005260:Female; D016285:Iloprost / Q000008:administration & dosage / Q000494:pharmacology*; D007269:Injections, Intra-Arterial; D002546:Ischemic Attack, Transient / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D011817:Rabbits; D013345:Subarachnoid Hemorrhage / Q000473:pathology
D016232:Endothelins; D016285:Iloprost