Clastogenicity of trophosphamide in somatic and germinal cells of mice.
Trophosphamide, a chemotherapeutic agent structurally related to cyclophosphamide, was tested in the micronucleus and heritable translocation assays in mice. It induced a linear increase of micronuclei in polychromatic erythrocytes 24 h after treatment with 1, 5, 25 or 50 mg/kg. In spermatids and spermatozoa of mice heritable translocations were induced by 150 mg/kg with an average frequency of 6%. The doubling doses calculated for micronucleus induction and heritable translocation induction were 5.0 and 1.3 mg/kg, respectively. These values are in the same order of magnitude and suggest that somatic and germinal cells are similarly sensitive to the clastogenic action of trophosphamide.
Adler
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GSF-Forschungszentrum für Umwelt und Gesundheit, GmbH, Institut für Säugetiergenetik, Neuherberg, Oberschleissheim, Germany.
Schriever-Schwemmer
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Kliesch
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D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000633:toxicity; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D013087:Spermatids / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects*; D014178:Translocation, Genetic
D000970:Antineoplastic Agents; D009153:Mutagens; D003520:Cyclophosphamide; C003726:trofosfamide