title: Regulation of interleukin-5 production by peripheral blood mononuclear cells from atopic patients with FK506, cyclosporin A and glucocorticoid.
abstract: Upon stimulation with phorbol ester and ionomycin, peripheral blood mononuclear cells (PBMC) of atopic patients with moderate eosinophilia produced significantly higher amounts of IL-5 compared to that of normal subjects. This finding renders further support to the notion that T cell-eosinophilic inflammation plays a central role in allergic disorders. IL-5 induction in vitro was completely inhibited by immunosuppressant FK506, cyclosporin A and dexamethasone. FK506 applied in vivo effectively suppressed clinical symptoms of atopic dermatitis and IL-5 production of PBMC. FK506 and cyclosporin A may become a better therapeutic modality against allergic diseases.
authors.affiliation: Department of Medicine, University of Tokyo, Faculty of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Suko
authors.forename: Y
authors.initials: Y
authors.lastname: Nishizaki
authors.forename: O
authors.initials: O
authors.lastname: Kaminuma
authors.forename: G
authors.initials: G
authors.lastname: Matsuzaki
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Etoh
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
authors.forename: N
authors.initials: N
authors.lastname: Tsuruoka
authors.forename: H
authors.initials: H
authors.lastname: Okudaira
mesh_terms: D000287:Administration, Topical; D001249:Asthma / Q000276:immunology; D002118:Calcium / Q000494:pharmacology; D016572:Cyclosporine / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood* / Q000188:drug therapy; D015848:Interleukin-5 / Q000096:biosynthesis*; D007476:Ionophores / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism*; D010703:Phorbol Esters / Q000494:pharmacology; D016559:Tacrolimus / Q000008:administration & dosage / Q000494:pharmacology*
chemical_list: D015848:Interleukin-5; D007476:Ionophores; D010703:Phorbol Esters; D003907:Dexamethasone; D016572:Cyclosporine; D002118:Calcium; D016559:Tacrolimus