title: Role of TCR zeta chain in T cell development and selection.
abstract: Signals mediated by the T cell receptor (TCR) are required for thymocyte maturation and selection. To examine the role of TCR zeta chain signals in development, TCR expression was restored in zeta-deficient mice with transgenic zeta chains that partially or completely lacked sequences required for signal transduction. The zeta chain played a role in thymic development by promoting TCR surface expression, but zeta-mediated signals were not essential because TCRs that contained signaling-deficient zeta chains promoted T cell maturation and transduced signals associated with thymic selection.
authors.affiliation: Division of Hematologic Products, Food and Drug Administration, Bethesda, MD 20892.
authors.forename: E W
authors.initials: EW
authors.lastname: Shores
authors.forename: K
authors.initials: K
authors.lastname: Huang
authors.forename: T
authors.initials: T
authors.lastname: Tran
authors.forename: E
authors.initials: E
authors.lastname: Lee
authors.forename: A
authors.initials: A
authors.lastname: Grinberg
authors.forename: P E
authors.initials: PE
authors.lastname: Love
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000032:analysis / Q000235:genetics; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D018956:CD5 Antigens; D016827:CD8 Antigens / Q000032:analysis; D004268:DNA-Binding Proteins; D015536:Down-Regulation; D015870:Gene Expression; D018398:Homeodomain Proteins; D037181:Lectins, C-Type; D008198:Lymph Nodes / Q000276:immunology; D008565:Membrane Proteins / Q000235:genetics / Q000502:physiology*; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D011506:Proteins / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D000099192:CD69 Antigens
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015704:CD4 Antigens; D018956:CD5 Antigens; D016827:CD8 Antigens; D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D037181:Lectins, C-Type; D008565:Membrane Proteins; D011506:Proteins; D012333:RNA, Messenger; D011948:Receptors, Antigen, T-Cell; D000099192:CD69 Antigens; C499308:Rag2 protein, mouse; C064655:V(D)J recombination activating protein 2; C054979:antigen T cell receptor, zeta chain; C064658:RAG-1 protein