[Control over prostatic functional activity].
The investigation of the tendency in the development of benign hyperplasia of the prostate is a crucial point in decision on the treatment initiation, schedule and policy. In view of this, the knowledge of the intensity of cellular proliferation and secretion, i.e. prostatic functional activity, in line with detrusor assessment is held essential. Optimal criteria of this value can be obtained by histological examination of prostatic biopsies, investigation of androgen and estrogen receptors in distant adenomatous nodes, by comparison of various biochemical ingredients in prostatic secretion. Twelve biochemical ingredients of prostatic secretion were studied in patients of the control group, in those with prostatic stones, adenoma, chronic prostatitis. The treatment included either androgenic, or antiandrogenic, or estrogenic therapy. Prostatic secretion biochemistry analyzed mathematically showed fluctuations in zinc ions concentration which appeared most significant. It is inferred that zinc ion concentration in prostatic secretion must be considered a significant means of overall evaluation of prostatic function able to represent the capacity of glandular epithelium for response to androgenic stimulation or estrogenic (antiandrogenic) inhibition of secretory and proliferative processes.
Goriunov
V G
VG
Kuz'min
G E
GE
Evdokimov
V V
VV
Evseev
L P
LP
Alakhverdov
G G
GG
D006801:Humans; D008297:Male; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000188:drug therapy / Q000503:physiopathology; D015032:Zinc / Q000032:analysis
D015032:Zinc