Serotonin receptors and therapeutics.
Since its discovery, serotonin (5-hydroxytryptamine = 5-HT) has become a major player on the neurotransmitter "stage". Multiple receptor subtypes for 5-HT have been identified and classified, and a vast pharmacology of 5-HT has emerged. In particular, 5-HT has been shown to exert marked effects on the cardiovascular system, central nervous system (CNS) and gastrointestinal (GI) tract, and important ligands have been developed that mimic or block its action selectively. Furthermore, drugs that release 5-HT, and others that prevent its uptake, have been developed. This brief review focuses on the pharmacology of 5-HT agonists and antagonists that exhibit, at least partly, clinical relevance.
Launay
J M
JM
FRA C. Bernard Neurochimie des Communications Cellulaires, Hôpital St. Louis, Paris, France.
Callebert
J
J
Bondoux
D
D
Loric
S
S
Maroteaux
L
L
D000818:Animals; D014151:Anti-Anxiety Agents / Q000627:therapeutic use; D000928:Antidepressive Agents / Q000627:therapeutic use; D000932:Antiemetics / Q000627:therapeutic use; D006224:Cricetinae; D000242:Cyclic AMP / Q000502:physiology; D004285:Dogs; D004330:Drosophila; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D001523:Mental Disorders / Q000188:drug therapy* / Q000503:physiopathology; D051379:Mice; D008881:Migraine Disorders / Q000188:drug therapy; D015394:Molecular Structure; D051381:Rats; D011985:Receptors, Serotonin / Q000145:classification / Q000187:drug effects* / Q000502:physiology; D012701:Serotonin / Q000502:physiology*; D012702:Serotonin Antagonists / Q000737:chemistry / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use*; D017366:Serotonin Receptor Agonists / Q000737:chemistry / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use*; D017367:Selective Serotonin Reuptake Inhibitors / Q000737:chemistry / Q000145:classification / Q000494:pharmacology / Q000627:therapeutic use*; D015398:Signal Transduction; D013329:Structure-Activity Relationship; D014839:Vomiting / Q000188:drug therapy
D014151:Anti-Anxiety Agents; D000928:Antidepressive Agents; D000932:Antiemetics; D000242:Cyclic AMP; D007473:Ion Channels; D011985:Receptors, Serotonin; D012701:Serotonin; D012702:Serotonin Antagonists; D017366:Serotonin Receptor Agonists; D017367:Selective Serotonin Reuptake Inhibitors