title: Endothelium localization of ETB receptor revealed by immunohistochemistry.
abstract: The ETB receptor has been found to be predominantly expressed in the vascular endothelium of various bovine tissues by immunostaining with a highly specific antiserum that does not cross-react with ETA. The tissues examined include the lung, trachea, kidney, adrenal gland, pituitary gland, and cerebellum. The wide-spread localization of ETB in the endothelial lining suggests that there is an ETB-mediated autocrine system of endothelin, which plays an important role in regulation of the functions of endothelial cells.
authors.affiliation: Department of Biological Sciences, Tokyo Institute of Technology, Japan.
authors.forename: M A
authors.initials: MA
authors.lastname: Ghoneim
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: S
authors.initials: S
authors.lastname: Hirose
authors.forename: T
authors.initials: T
authors.lastname: Nagasawa
authors.forename: H
authors.initials: H
authors.lastname: Hagiwara
mesh_terms: D000818:Animals; D000918:Antibody Specificity; D002417:Cattle; D004730:Endothelium, Vascular / Q000033:anatomy & histology / Q000378:metabolism*; D007150:Immunohistochemistry; D017466:Receptors, Endothelin / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*
chemical_list: D017466:Receptors, Endothelin