[Cytokeratin-positive angiosarcoma of the adrenal gland].
Cytological, biopsy and autopsy findings in a patients suffering from massively metastasizing adrenal angiosarcoma are reported. Histogenetic typing of the tumour initially manifestating itself by osseous and liver metastases was problematic with regard to its partially epithelioid structure and its positivity upon cytokeratin immunostaining. Of relevance for the correct typing was the finding that the tumour cells in addition exhibited positivity for vascular markers. This case confirms literature data according to which cytokeratin expression not infrequently may be encountered in endothelial neoplasms and which by no means should lead to exclude such a tentative diagnosis.
Jochum
W
W
Departement Pathologie, Universität Zürich.
Schröder
S
S
Risti
B
B
Marincek
B
B
von Hochstetter
A
A
D000310:Adrenal Gland Neoplasms / Q000473:pathology*; D000311:Adrenal Glands / Q000473:pathology; D000328:Adult; D000911:Antibodies, Monoclonal; D000941:Antigens / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D014408:Biomarkers, Tumor / Q000032:analysis*; D015815:Cell Adhesion Molecules / Q000032:analysis; D005167:Factor VII / Q000032:analysis; D005266:Femoral Neoplasms / Q000473:pathology / Q000556:secondary*; D005270:Femur Head / Q000473:pathology; D006394:Hemangiosarcoma / Q000473:pathology / Q000556:secondary*; D006801:Humans; D007633:Keratins / Q000032:analysis*; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000473:pathology / Q000556:secondary*; D008297:Male; D019408:Platelet Endothelial Cell Adhesion Molecule-1
D000911:Antibodies, Monoclonal; D000941:Antigens; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; D015815:Cell Adhesion Molecules; D019408:Platelet Endothelial Cell Adhesion Molecule-1; C031500:factor VII related antigen; D007633:Keratins; D005167:Factor VII