title: Coenzymes Q9 and Q10 in skeletal and cardiac muscle in tumour-bearing exercising rats.
abstract: Physical exercise increases metabolic rate, and induces both adaptational biogenesis of mitochondria in skeletal muscle and an increase in antioxidant capacity. The onset of experimental anorexia and cachexia can be delayed by voluntary exercise. As skeletal muscle is the main target for cancer cachexia, we determined the levels of coenzymes Q9 and Q10 in skeletal muscle from tumour-bearing exercising rats, and compared them to those of sedentary tumour-bearers and controls. Both tumour-bearing groups had increased levels of coenzymes Q9 and Q10 in the anterior tibial muscle (P < 0.05 for exercised animals). In the soleus muscle, only the tumour-bearing exercising animals demonstrated an increase in the levels of both coenzymes (P < 0.05). In cardiac muscle, the presence of tumour and exercise reduced the levels of coenzymes below that of sedentary controls. Exercise counteracted the anaemia in the tumour-bearing host (P < 0.05). In conclusion, the increase in antioxidant capacity in skeletal muscle indicates a defence mechanism in the tumour-bearing hosts which is augmented by physical exercise.
authors.affiliation: Department of Surgery, Sahlgrenska Hospital, University of Göteborg, Sweden.
authors.forename: P
authors.initials: P
authors.lastname: Daneryd
authors.forename: F
authors.initials: F
authors.lastname: Aberg
authors.forename: G
authors.initials: G
authors.lastname: Dallner
authors.forename: L
authors.initials: L
authors.lastname: Ernster
authors.forename: T
authors.initials: T
authors.lastname: Scherstén
authors.forename: B
authors.initials: B
authors.lastname: Soussi
mesh_terms: D000818:Animals; D002100:Cachexia / Q000201:enzymology; D003067:Coenzymes; D004734:Energy Metabolism; D005260:Female; D018482:Muscle, Skeletal / Q000201:enzymology*; D009206:Myocardium / Q000201:enzymology*; D009374:Neoplasms, Experimental / Q000201:enzymology*; D010805:Physical Conditioning, Animal / Q000502:physiology*; D051381:Rats; D011920:Rats, Inbred WF; D014451:Ubiquinone / Q000031:analogs & derivatives / Q000378:metabolism*
chemical_list: D003067:Coenzymes; D014451:Ubiquinone; C024989:coenzyme Q10; C030571:ubiquinone 9