[A study of biological characteristics of large bowel adenocarcinomas showing mucin production; examination of histological differentiation and cell kinetics].
In order to clarify the biological behavior of mucin producing cancers of colon, we analyzed 32 cases showing histological heterogeneity in the tumors, by mucin histochemistry. 28 cases were mucinous adenocarcinoma, forming with tubular structures, and the remaining 4 cases were signet-ring cell carcinomas. HID-AB stain demonstrated that the mucin component was almost similar to that of normal mucosa around the cancer. In the tubular forming portions, in which polyploid or aneuploid cells were often detected, the growth fraction of cancers was significantly higher than in that of the other portions.
Kawasaki
C
C
Department of Pathology, Shiga University of Medical Science.
Hosokawa
Y
Y
Hattori
T
T
Suwo
M
M
Hirano
M
M
Yamamoto
A
A
Fujimura
M
M
Mori
A
A
D002288:Adenocarcinoma, Mucinous / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018279:Carcinoma, Signet Ring Cell / Q000378:metabolism / Q000401:mortality / Q000473:pathology; D002453:Cell Cycle; D003110:Colonic Neoplasms / Q000378:metabolism / Q000401:mortality / Q000473:pathology*; D004273:DNA, Neoplasm / Q000032:analysis; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009077:Mucins / Q000096:biosynthesis*; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen; D013194:Staining and Labeling; D015996:Survival Rate
D004273:DNA, Neoplasm; D009077:Mucins; D009687:Nuclear Proteins; D018809:Proliferating Cell Nuclear Antigen