title: Increased activity of gamma-glutamyl hydrolase in human sarcoma cell lines: a novel mechanism of intrinsic resistance to methotrexate (MTX).
authors.affiliation: Program of Molecular Pharmacology and Therapeutics, Sloan-Kettering Institute for Cancer Research, New York, NY 10021.
authors.forename: W W
authors.initials: WW
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Waltham
authors.forename: W
authors.initials: W
authors.lastname: Tong
authors.forename: B I
authors.initials: BI
authors.lastname: Schweitzer
authors.forename: J R
authors.initials: JR
authors.lastname: Bertino
mesh_terms: D002460:Cell Line; D004351:Drug Resistance / Q000502:physiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D007945:Leukemia, Lymphoid; D008727:Methotrexate / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism / Q000633:toxicity*; D011099:Polyglutamic Acid / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism; D014407:Tumor Cells, Cultured; D011623:gamma-Glutamyl Hydrolase / Q000378:metabolism*
chemical_list: D011099:Polyglutamic Acid; C014085:methotrexate polyglutamate; D011623:gamma-Glutamyl Hydrolase; D008727:Methotrexate