[The localization and preliminary characteristics of antigenic sites (B epitopes) in the nucleocapsid protein of the Lassa virus].
Nucleocapsid protein of Lassa virus contains 4 epitope sites. Three of them were localized in amino acid position 123-1 27, 337-346, and 518-527. Monoclonal antibody 1108 specific to Lassa virus NP-protein reacted with 123-127 synthetic peptide in solid-phase ELISA and precipitated nucleocapsid proteins of Machupo, Tacaribe, and Mopeia arenaviruses in RIP.
Vladyko
A S
AS
Bystrova
S I
SI
Malakhova
I V
IV
Kunitskaia
L Ia
LIa
Lemeshko
N N
NN
Kras'ko
A G
AG
Kozhich
A T
AT
Lukashevich
I S
IS
D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000097:blood*; D001116:Arenaviridae / Q000235:genetics / Q000276:immunology; D002213:Capsid / Q000235:genetics / Q000276:immunology*; D036022:Capsid Proteins; D000939:Epitopes / Q000097:blood*; D006168:Guinea Pigs; D007114:Immunization; D007836:Lassa virus / Q000235:genetics / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000235:genetics / Q000276:immunology; D018075:RNA, Complementary / Q000235:genetics; D012367:RNA, Viral / Q000235:genetics; D015531:Radioimmunoprecipitation Assay; D014758:Viral Core Proteins / Q000235:genetics / Q000276:immunology*
D000956:Antigens, Viral; D036022:Capsid Proteins; D000939:Epitopes; D009842:Oligopeptides; D018075:RNA, Complementary; D012367:RNA, Viral; D014758:Viral Core Proteins; C110151:nucleocapsid protein, lassa virus