title: Primary pulmonary germ cell tumor with blastomatous differentiation.
abstract: We describe the clinical and pathologic findings of a patient with mixed blastoma-germ cell malignancy primary in the lung. Serum alpha-fetoprotein levels were elevated at presentation, and normalized with anti-germ cell chemotherapy. The resection specimen contained massively necrotic germ cell tumor with viable mature neural tissue, plus viable biphasic blastoma with stromal bone and skeletal muscle differentiation. It is not clear whether the germ cell component represents unusual differentiation of a somatic cell line or whether the blastoma component represents an unusual pattern of teratomatous differentiation.
authors.affiliation: Department of Pathology, Vancouver General Hospital, British Columbia, Canada.
authors.forename: R R
authors.initials: RR
authors.lastname: Miller
authors.forename: K
authors.initials: K
authors.lastname: Champagne
authors.forename: R C
authors.initials: RC
authors.lastname: Murray
mesh_terms: D003537:Cystadenoma / Q000097:blood / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D018237:Germinoma / Q000097:blood / Q000473:pathology*; D006392:Hemangioma, Cavernous / Q000097:blood / Q000473:pathology; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood / Q000473:pathology; D008175:Lung Neoplasms / Q000097:blood / Q000473:pathology*; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000097:blood / Q000473:pathology*; D010051:Ovarian Neoplasms / Q000097:blood / Q000473:pathology; D018202:Pulmonary Blastoma / Q000097:blood / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins