title: Transient expression of beta-NADPH diaphorase in developing rat dorsal root ganglia neurons.
abstract: We report here that during early fetal rat development, most, if not all, dorsal root ganglion (DRG) cells were stained by the beta-NADPH diaphorase histochemical reaction, indicating that they expressed nitric oxide synthase. During late fetal development, most DRG cells lost their diaphorase activity, but a small subset (located in all DRGs, but primarily in mid-thoracic DRGs) remained diaphorase-positive in adult animals. The transient expression of this enzyme suggests that nitric oxide may play a role during development that differs from its function in mature cells.
authors.affiliation: Division of Neuroscience, Beckman Research Institute of the City of Hope, Duarte, CA 91010-0269.
authors.forename: R
authors.initials: R
authors.lastname: Wetts
authors.forename: J E
authors.initials: JE
authors.lastname: Vaughn
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000032:analysis; D000818:Animals; D005314:Embryonic and Fetal Development / Q000502:physiology; D005727:Ganglia, Spinal / Q000166:cytology / Q000196:embryology / Q000201:enzymology*; D009252:NADPH Dehydrogenase / Q000032:analysis*; D009474:Neurons / Q000201:enzymology*; D019001:Nitric Oxide Synthase; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D009252:NADPH Dehydrogenase