title: [Physiopathology of pruritus].
abstract: Itching is the predominant symptom of inflammatory skin diseases. Present evidence indicates that histamine and unidentified peptides mediate itching. No evidence is available that lymphokines or cytokines play a direct role as itch mediators. Prostaglandins serve an important synergistic function in itching. Evidence points to a role for opioid peptides of the central nervous system in the perception of itch and as direct mediators. Pruritus may be a prominent symptom in uraemia, biliary obstruction, atopic dermatitis and neoplasia.
authors.affiliation: Service de Dermatologie, Hôpitaux St Pierre et Brugmann, Bruxelles.
authors.forename: M
authors.initials: M
authors.lastname: Song
mesh_terms: D006636:Histamine Release; D006801:Humans; D018847:Opioid Peptides / Q000502:physiology; D011458:Prostaglandins E / Q000502:physiology; D011537:Pruritus / Q000503:physiopathology*; D012871:Skin Diseases / Q000503:physiopathology*; D012881:Skin Temperature
chemical_list: D018847:Opioid Peptides; D011458:Prostaglandins E