Effects of irradiation on the expression of the adhesion molecules (NCAM, ICAM-1) by glioma cell lines.
The expression of the intercellular adhesion molecule-1 (ICAM-1) and neural cell adhesion molecule (NCAM) by glioma cell lines was investigated. The effects of interferon (IFN)-gamma or irradiation on the expression was also assessed. Two glioma cell lines showed more than 75% NCAM-positive cells. After treatment with IFN-gamma or irradiation, another three cell lines were induced to show more than 50% positive cells. Three glioma cell lines showed more than 50% ICAM-1-positive cells. After treatment with IFN-gamma, another two cell lines were induced to show more than 50% positive cells. After treatment with irradiation, one more cell line was induced to show more than 50% positive cells. ICAM-1 and NCAM expression by glioma cell lines is susceptible to modulation by IFN-gamma or irradiation.
Yamanaka
R
R
Department of Neurosurgery, Niigata University.
Tanaka
R
R
Yoshida
S
S
D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D015816:Cell Adhesion Molecules, Neuronal / Q000096:biosynthesis*; D002460:Cell Line; D005910:Glioma / Q000378:metabolism*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma / Q000494:pharmacology; D039841:Leukocyte L1 Antigen Complex; D011830:Radiation Effects; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000528:radiation effects
D015815:Cell Adhesion Molecules; D015816:Cell Adhesion Molecules, Neuronal; D039841:Leukocyte L1 Antigen Complex; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma