title: A comparison of nimesulide and placebo in the treatment of minor traumatic soft tissue lesions in children.
abstract: A total of 40 children with minor traumatic injuries of soft tissues were randomly assigned to oral treatment with nimesulide (50mg twice daily) or placebo for 5 days in a double-blind investigation. Results demonstrated that therapy with nimesulide was associated with a significant resolution of symptoms (pain at rest and during movement) and signs (oedema, immobility and haematoma), which was statistically superior to that demonstrated for placebo. Furthermore, nimesulide was well tolerated by all patients and was not associated with gastrointestinal problems. These findings suggest that nimesulide is a suitable therapy for children with minor traumatic lesions.
authors.affiliation: V Clinica Pediatrica, Università di Milano, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Giovannini
authors.forename: G V
authors.initials: GV
authors.lastname: Zuccotti
authors.forename: I
authors.initials: I
authors.lastname: Scaricabarozzi
authors.forename: V
authors.initials: V
authors.lastname: Locatelli
authors.forename: E
authors.initials: E
authors.lastname: Riva
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002648:Child; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D010919:Placebos; D017695:Soft Tissue Injuries / Q000188:drug therapy*; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010919:Placebos; D013449:Sulfonamides; C012655:nimesulide