title: Tissue repair: a critical determinant in CCl4 hepatotoxicity.
abstract: A single antimitotic dose of colchicine administered 24 hr after a single ip dose of CCl4 profoundly enhanced lethality in the adult Sprague-Dawley male rat from < 10% to over > or = 70% within the next 24 hr. These findings suggest that disruption of normal hepatic cellular repair processes is a critical factor affecting the outcome of CCl4 intoxication.
authors.affiliation: School of Public Health, University of Massachusetts, Amherst 01003.
authors.forename: E J
authors.initials: EJ
authors.lastname: Calabrese
authors.forename: D A
authors.initials: DA
authors.lastname: Leonard
authors.forename: L A
authors.initials: LA
authors.lastname: Baldwin
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000473:pathology*; D056486:Chemical and Drug Induced Liver Injury / Q000473:pathology*; D003078:Colchicine / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D003078:Colchicine