title: Are rogue cells an indicator of cancer risk due to the action of bacterial restriction endonucleases?
abstract: Cytogenetic surveys in normal individuals have occasionally shown the occurrence of cells with multiple chromosome-type aberrations in some of the subjects. These cells, which are rare, have been termed as rogue cells. Rogue cells, which have been observed worldwide, have a mysterious nature. It has been suggested that they may give rise to cancer. Various mechanisms have been considered for the causation of the rouge-cell phenomenon in the past but none of them appears to be fully justified. In this paper we propose their occurrence due to the action of bacterial restriction endonucleases.
authors.affiliation: Genetics Unit, Bhagwan Mahavir Medical Research Centre, Hyderabad, India.
authors.forename: Y R
authors.initials: YR
authors.lastname: Ahuja
authors.forename: G
authors.initials: G
authors.lastname: Obe
mesh_terms: D000818:Animals; D001419:Bacteria / Q000201:enzymology*; D001424:Bacterial Infections / Q000201:enzymology / Q000235:genetics; D002869:Chromosome Aberrations; D004262:DNA Restriction Enzymes / Q000378:metabolism*; D006801:Humans; D007621:Karyotyping; D009369:Neoplasms / Q000209:etiology / Q000235:genetics / Q000473:pathology*; D011230:Precancerous Conditions / Q000378:metabolism; D012307:Risk Factors
chemical_list: D004262:DNA Restriction Enzymes