title: Stabilization of inducible nitric oxide synthase by monoclonal antibodies.
abstract: We have produced 14 monoclonal antibodies to inducible nitric oxide synthase purified from rat peritoneal cytotoxic activated macrophages. None of the antibodies showed neutralizing activity, but some of them enhanced the enzyme activity through stabilization of the enzyme.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Hattori
authors.forename: K
authors.initials: K
authors.lastname: Kosuga
authors.forename: H
authors.initials: H
authors.lastname: Eizawa
authors.forename: K
authors.initials: K
authors.lastname: Sase
authors.forename: R
authors.initials: R
authors.lastname: Inoue
authors.forename: M
authors.initials: M
authors.lastname: Sunamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Ichimori
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: T
authors.initials: T
authors.lastname: Mori
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis* / Q000276:immunology; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D015153:Blotting, Western; D004790:Enzyme Induction; D005260:Female; D006801:Humans; D006825:Hybridomas; D007150:Immunohistochemistry; D007223:Infant; D051379:Mice; D008807:Mice, Inbred BALB C; D019001:Nitric Oxide Synthase; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000911:Antibodies, Monoclonal; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases