Thyroid hormone excess and osteoporosis.
Current thinking and available clinical data on the relationship between hyperthyroidism and bone disease are discussed. Data are also presented on TSH-suppressive and non-suppressive thyroid hormone therapy and its effect on bone. Although these data are clearly inconsistent, some risk factors for thyroid hormone induced osteopenia seem to be accepted: long standing, clinically manifest hyperthyroidism (a very rare disorder today because of early diagnosis and appropriate therapy), old age, menopause and total thyroidectomy. Thyroid hormone therapy (whether TSH-suppressive or not) has not been proven so far to lead to manifest osteoporosis.
Leb
G
G
Medical University Clinic, Karl Franzens University, Graz, Austria.
Warnkross
H
H
Obermayer-Pietsch
B
B
D000328:Adult; D000368:Aged; D013956:Antithyroid Agents / Q000009:adverse effects / Q000627:therapeutic use; D001851:Bone Diseases, Metabolic / Q000139:chemically induced / Q000503:physiopathology; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000139:chemically induced / Q000503:physiopathology*; D012307:Risk Factors; D013963:Thyroid Hormones / Q000502:physiology; D013972:Thyrotropin / Q000037:antagonists & inhibitors / Q000502:physiology
D013956:Antithyroid Agents; D013963:Thyroid Hormones; D013972:Thyrotropin