[The induction of alloantigen-specific cytotoxic T-lymphocytes by the intravenous immunization of mice].
It is shown possible to induce specific cytotoxic T-lymphocytes (CTL) in the course of intravenous (i.v.) immunization of Balb/c mice by 2000-rad-irradiated allogeneic C57Bl/6 splenocytes in a dose of 9 x 10(7). The induced CTL express Thy1.2+L3T4-Ly2+ cell surface markers. No correlation was observed between the level of cytotoxic activity and the ability to inhibit proliferation in the population of lymphocytes primed by i.v. immunization.
Krivoshein
Iu S
IuS
Anosova
N G
NG
Brondz
B D
BD
Kronin
V V
VV
Popov
I A
IA
D000818:Animals; D003601:Cytotoxicity Tests, Immunologic; D000939:Epitopes / Q000276:immunology*; D007114:Immunization / Q000379:methods*; D007275:Injections, Intravenous; D007519:Isoantigens / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D013154:Spleen / Q000166:cytology / Q000276:immunology / Q000528:radiation effects / Q000637:transplantation; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D018800:Thy-1 Antigens / Q000276:immunology
D000939:Epitopes; D007519:Isoantigens; D018800:Thy-1 Antigens