5-HT-related, anxiety- and/or aggression-driven depression.
Mood lowering is considered to be the prime factor in the diagnosis of depression. However, it has been proposed that in a subset of cases of depression, the primary symptoms are anxiety and/or aggression. It has also been shown that these symptoms coincide with disturbance of 5-hydroxytryptamine (5-HT), which is frequently seen in depressed patients and has been suggested to be a vulnerability factor in the onset of depressive phases. If the concept of this proposed subset of depression--termed "5-HT-related, anxiety-and/or aggression-driven depression"--is accepted, this will lead to a review of the mode of diagnosis of depression and a reorientation of research into antidepressant drugs.
Van Praag
H M
HM
Academic Psychiatric Centre, University of Limburg, Maastrict, The Netherlands.
D000374:Aggression / Q000187:drug effects / Q000502:physiology*; D000928:Antidepressive Agents / Q000627:therapeutic use; D001008:Anxiety Disorders / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D003866:Depressive Disorder / Q000188:drug therapy / Q000503:physiopathology* / Q000523:psychology; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012701:Serotonin / Q000502:physiology*
D000928:Antidepressive Agents; D011985:Receptors, Serotonin; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid