Inhibitory effect of calf fetuin on the cytotoxic activity of LAK cell-derived factors and tumor necrosis factor.
A protein-inhibiting LAK cell-mediated cytotoxicity was isolated from a LAK cell-conditioned medium. The N-terminal amino acid sequence of this protein appeared to be identical to fetal calf fetuin. Pure isolated fetuin, as well as commercially available preparations of this protein, were shown to inhibit cytotoxic activity of both cytotoxic proteins released by LAK cells and TNF.
Chertov OYu
Shemyakin Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow.
Ermolaeva
M V
MV
Satpaev
D K
DK
Saschenko
L P
LP
Kabanova
O D
OD
Lukanidin
E M
EM
Lukjianova
T I
TI
Redchenko
I V
IV
Blishchenko LYu
Gnuchev
N V
NV
D000818:Animals; D002417:Cattle; D017077:Culture Media, Conditioned; D003602:Cytotoxicity, Immunologic; D005347:Fibroblasts; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D051379:Mice; D011994:Recombinant Proteins / Q000096:biosynthesis; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*; D000509:alpha-Fetoproteins / Q000276:immunology*
D017077:Culture Media, Conditioned; D011994:Recombinant Proteins; D014409:Tumor Necrosis Factor-alpha; D000509:alpha-Fetoproteins