title: Current density analysis of outward currents in acutely isolated rat entorhinal cortex cells.
abstract: Entorhinal cortex stellate and pyramidal cells were acutely isolated from juvenile rats. Using the whole-cell configuration of the patch-clamp method outward potassium currents were recorded. A fast transient A-current and a sustained outward current could be measured in both stellate and pyramidal cells. The A-current density was significantly larger in pyramidal cells than in stellate cells. In contrast, stellate cells possessed a larger current density of the delayed rectifier current as well as the Ca2+ activated K+ current than pyramidal cells. Moreover, superficial stellate cells exhibited large delayed rectifier currents and only small A-currents while entorhinal cortex deep layer pyramidal cells displayed larger A-currents than delayed rectifier currents.
authors.affiliation: Institut für Neurophysiologie, Universität zu Köln, FRG.
authors.forename: C
authors.initials: C
authors.lastname: Eder
authors.forename: U
authors.initials: U
authors.lastname: Heinemann
mesh_terms: D000818:Animals; D002118:Calcium / Q000502:physiology; D018728:Entorhinal Cortex / Q000166:cytology / Q000378:metabolism*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D015221:Potassium Channels / Q000187:drug effects / Q000378:metabolism; D017966:Pyramidal Cells / Q000187:drug effects / Q000378:metabolism; D051381:Rats
chemical_list: D007473:Ion Channels; D015221:Potassium Channels; D002118:Calcium