title: Inhibition of a 5-HT3 receptor-mediated current by the selective serotonin uptake inhibitor, fluoxetine.
abstract: The effect of the selective serotonin uptake inhibitor, fluoxetine, on the inward current mediated by 5-HT3 receptors was investigated with the whole-cell patch-clamp technique. Fluoxetine inhibited the peak 5-HT current with an IC50 value of 1.2 microM. During continuous application of fluoxetine at concentrations of < or = 1 microM, there was a transient decrease in the fluoxetine-induced inhibition of 5-HT current. It is suggested that fluoxetine may have a short-lived action on 5-HT current and that the 5-HT3 receptor is a possible acting site for the therapeutic use of fluoxetine.
authors.affiliation: Laboratory of Molecular and Cellular Neurobiology, National Institute on Alcohol Abuse and Alcoholism, Rockville, MD 20852.
authors.forename: P
authors.initials: P
authors.lastname: Fan
mesh_terms: D000818:Animals; D004594:Electrophysiology; D005473:Fluoxetine / Q000494:pharmacology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism*; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009620:Nodose Ganglion / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000502:physiology; D012702:Serotonin Antagonists / Q000378:metabolism
chemical_list: D007473:Ion Channels; D012702:Serotonin Antagonists; D005473:Fluoxetine; D012701:Serotonin