title: Effects of weight reduction on circulating parathyroid hypertensive factor levels.
abstract: This study evaluated changes in parathyroid hypertensive factor (PHF) in 18 obese individuals. PHF levels were measured prior to the onset of a low calorie diet (800 kcal/day), and at 3-4 weeks, 7-8 weeks, and 11-12 weeks after initiation of the diet. Blood pressure, forearm vascular resistance, and platelet intracellular calcium ([Ca2+]i) levels were also measured at the same time. Although blood pressure, vascular resistance, and platelet [Ca2+]i decreased significantly in association with the low-calorie diet and weight reduction, PHF levels did not change significantly during the 12-week diet period. We conclude that PHF levels do not track with reductions in blood pressure, vascular resistance, and platelet [Ca2+]i levels in obese individuals.
authors.affiliation: Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201.
authors.forename: J R
authors.initials: JR
authors.lastname: Sowers
authors.forename: P R
authors.initials: PR
authors.lastname: Standley
authors.forename: R Z
authors.initials: RZ
authors.lastname: Lewanczuk
authors.forename: P K
authors.initials: PK
authors.lastname: Pang
mesh_terms: D000818:Animals; D001685:Biological Factors / Q000097:blood*; D001792:Blood Platelets / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002118:Calcium / Q000097:blood; D004038:Diet, Reducing; D005260:Female; D006801:Humans; D008297:Male; D009765:Obesity / Q000097:blood / Q000178:diet therapy; D051381:Rats; D017207:Rats, Sprague-Dawley; D014655:Vascular Resistance / Q000502:physiology; D015431:Weight Loss / Q000502:physiology*
chemical_list: D001685:Biological Factors; C064505:parathyroid hypertensive factor; D002118:Calcium