[Inhibitors of plasmin-like enzymes and autofibronectin in the treatment of corneal epithelial defects].
Effects of instillations of proteinase inhibitors and autologous fibronectin on the course of regeneration processes in corneal epithelial defects were studied in patients after perforating and lamellar keratoplasty, cataract extraction, trabecul- and vitrectomy. Proteinase inhibitors contrykal or gordox were administered to these patients to neutralize increased activity of lacrimal plasmin-like enzymes which was 899.3 +/- 80.8 rel. U on day 1 of observation vs. 50.72 +/- 7.73 in normal subjects. Contrykal (gordox) helped significantly reduce these enzymes activities in patients with corneal epithelial defects in comparison with the control group as soon as during the first days of the observation. Combined use of contrykal (gordox) and autologous fibronectin helped attain complete epithelialization in all the patients in 12.3 +/- 1.7 days (47.9 +/- 6.3 days in controls).
Polunin
G S
GS
Kasparov
A A
AA
Makarov
I A
IA
Ovchinnikov
A N
AN
D007611:Aprotinin / Q000627:therapeutic use; D003316:Corneal Diseases / Q000188:drug therapy* / Q000201:enzymology; D004341:Drug Evaluation; D004728:Endothelium, Corneal / Q000187:drug effects*; D005341:Fibrinolysin / Q000032:analysis / Q000037:antagonists & inhibitors*; D005353:Fibronectins / Q000302:isolation & purification / Q000627:therapeutic use*; D006801:Humans; D011183:Postoperative Complications / Q000188:drug therapy* / Q000201:enzymology; D011480:Protease Inhibitors / Q000627:therapeutic use*; D013666:Tears / Q000201:enzymology; D013997:Time Factors; D014361:Trypsin Inhibitors / Q000627:therapeutic use
D005353:Fibronectins; D011480:Protease Inhibitors; D014361:Trypsin Inhibitors; C011475:gordox; D007611:Aprotinin; D005341:Fibrinolysin