Antitumoral effect of bleomycin+dolomite combination treatment, in mice bearing Ehrlich ascites carcinoma.
Dolomite, a mineral composed of magnesium and calcium carbonates, potentiates the antitumoral activity of bleomycin: While 40 days after inoculation, no mice survived the Ehrlich ascites tumor burden, 44% of them survived it after bleomycin treatment, and 63% after a simultaneous treatment of bleomycin and dolomite. The beneficial antitumor effect of dolomite is probably related to its high content (12.8%) of magnesium.
Scheller
S
S
Department of Microbiology and Immunology, Silesian School of Medicine, Zabrze-Rokitnica, Poland.
Krol
W
W
Skirmuntt
K
K
Zydowicz
G
G
Shani
J
J
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage / Q000627:therapeutic use*; D002119:Calcium Carbonate / Q000008:administration & dosage / Q000627:therapeutic use*; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy*; D005260:Female; D008274:Magnesium / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008903:Minerals / Q000627:therapeutic use
D008903:Minerals; D001761:Bleomycin; D002119:Calcium Carbonate; D008274:Magnesium; C028042:calcium magnesium carbonate