Stem cell factor is a potent synergistic factor in hematopoiesis.
Stem cell factor (SCF), a ligand for c-kit, has a broad range of activities including effects on cells at or near the level of the multipotential stem cell as well as on committed cells. Preclinical studies show that SCF can protect against lethal irradiation, elicit multilineage responses in peripheral blood and bone marrow cellularity, and increase circulating peripheral blood progenitor cells (PBPC) in a dose-dependent manner. Recombinant human SCF has major clinical potential through its synergy with other factors, especially recombinant human granulocyte colony-stimulating factor, to enhance mobilization of PBPC.
Morstyn
G
G
Amgen Inc., Thousand Oaks, CA 91320-1789.
Brown
S
S
Gordon
M
M
Crawford
J
J
Demetri
G
G
Rich
W
W
McGuire
B
B
Foote
M
M
McNiece
I
I
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D006410:Hematopoiesis / Q000502:physiology*; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000502:physiology; D006801:Humans; D066298:In Vitro Techniques; D009369:Neoplasms / Q000628:therapy; D019089:Stem Cell Factor
D016298:Hematopoietic Cell Growth Factors; D019089:Stem Cell Factor