Isoprinosine stimulates granulocyte chemiluminescence and inhibits monocyte chemiluminescence in vitro.
Isoprinosine may delay disease progression in human immunodeficiency virus infection, presumably through modulation of lymphocyte function. However, the influence of isoprinosine on phagocyte function is largely unknown. This study describes the effects of isoprinosine and azidothymidine on phagocyte chemiluminescence and migration. Incubation with isoprinosine concentrations of 250 micrograms/ml and above increased the chemiluminescence of granulocytes. Random migration of granulocytes was decreased at isoprinosine concentrations of 50 micrograms/ml and higher, but chemotaxis was not affected. Azidothymidine exerted no effect on the chemiluminescence or migration of granulocytes. For monocytes, luminol-enhanced chemiluminescence was reduced at isoprinosine concentrations of 250 micrograms/ml and above, whereas migration was not affected. These findings suggest that the immunomodulatory properties of isoprinosine may extend to phagocytic cells. This may be of significance in the treatment of immunodeficiency states.
Flø
R W
RW
Medical Department B, Haukeland Hospital, University of Bergen, Norway.
Naess
A
A
Albrektsen
G
G
Solberg
C O
CO
D002465:Cell Movement / Q000187:drug effects; D002634:Chemotaxis, Leukocyte / Q000187:drug effects; D006098:Granulocytes / Q000166:cytology* / Q000187:drug effects; D006801:Humans; D066298:In Vitro Techniques; D007542:Inosine Pranobex / Q000494:pharmacology*; D008163:Luminescent Measurements; D009000:Monocytes / Q000166:cytology* / Q000187:drug effects; D015215:Zidovudine / Q000494:pharmacology
D015215:Zidovudine; D007542:Inosine Pranobex