title: Resistance to pseudorabies virus with enhanced interferon production and natural killer cell activity in mice treated with serum thymic factor.
abstract: Susceptibility to pseudorabies virus (PRV) infection in mice, which were continuously depleted of natural killer (NK) cell activity by injection of anti-asialo GM1, was examined. Effects of serum thymic factor (FTS) on susceptibility of mice to PRV were also investigated. In mice with depleted NK cell activity, the mortality of PRV-infected mice was markedly high, whereas that of FTS-pretreated mice was significantly lower than the controls. Reduced susceptibility to PRV was demonstrated in mice treated with anti-asialo GM1 antisera before the PRV infection. Such a reduced susceptibility was not observed in mice inoculated with the antisera on day 1 post-infection (PI). To analyze the FTS-induced resistance to PRV infection, NK cell activity, macrophage activity, and interferon (IFN) productions were studied. Interferon production and NK cell activity were enhanced in the FTS-pretreated mice, suggesting that interferon may play an important role in this FTS-induced resistance to PRV infection.
authors.affiliation: National Institute of Animal Health, Ibaraki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Onodera
authors.forename: K
authors.initials: K
authors.lastname: Yoshihara
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Tsuda
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: A
authors.initials: A
authors.lastname: Awaya
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Yukawa
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004198:Disease Susceptibility / Q000276:immunology; D005677:G(M1) Ganglioside / Q000037:antagonists & inhibitors / Q000276:immunology; D011558:Herpesvirus 1, Suid / Q000276:immunology / Q000472:pathogenicity / Q000502:physiology*; D007106:Immune Sera; D007113:Immunity, Innate; D007372:Interferons / Q000096:biosynthesis*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D008262:Macrophage Activation; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D011557:Pseudorabies / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms; D013935:Thymic Factor, Circulating / Q000494:pharmacology / Q000627:therapeutic use*; D014774:Virulence; D014779:Virus Replication
chemical_list: D007106:Immune Sera; D005677:G(M1) Ganglioside; C018835:asialo GM1 ganglioside; D007372:Interferons; D013935:Thymic Factor, Circulating