title: Prostate-specific antigen and transrectal ultrasound of the prostate in detection of prostate cancer.
abstract: Detection of prostate cancer can be enhanced over the level historically obtained by digital rectal examination through the combined use of serum prostate-specific antigen and digital rectal examination, followed by transrectal ultrasonic examination of the prostate and ultrasonically guided biopsy if either of the initial studies is abnormal. Use of age-specific reference ranges for prostate-specific antigen results in greater sensitivity of this serum marker in patients below the age of 60 y and greater specificity in older patients.
authors.affiliation: Section of Urology, Emory University School of Medicine, Atlanta, Georgia.
authors.forename: W H
authors.initials: WH
authors.lastname: Cooner
mesh_terms: D006801:Humans; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000000981:diagnostic imaging*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000601:surgery; D012007:Rectum / Q000000981:diagnostic imaging; D018084:Ultrasonography, Interventional / Q000379:methods
chemical_list: D017430:Prostate-Specific Antigen