Preferential inhibition of inducible nitric oxide synthase by ebselen.
Ebselen, 2-phenyl-1,2-benzisoselenazole-3(2H)-one can preferentially inhibit the activity of inducible nitric oxide (NO) synthase with little inhibition of endothelial constitutive NO synthase within a certain concentration range. This suggests that ebselen deserves further in vivo studies to examine its possible application to the therapy of septic shock where inducible NO synthase is responsible for vasodilation.
Hattori
R
R
Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
Inoue
R
R
Sase
K
K
Eizawa
H
H
Kosuga
K
K
Aoyama
T
T
Masayasu
H
H
Kawai
C
C
Sasayama
S
S
Yui
Y
Y
D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D002417:Cattle; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology; D004790:Enzyme Induction; D054833:Isoindoles; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000201:enzymology; D019001:Nitric Oxide Synthase; D016566:Organoselenium Compounds / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D001393:Azoles; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases