Alteration in the antigenic structure of M1 protein of influenza A virus mutant resistant to a new antiviral compound mopyridone.
Using 14 monoclonal antibodies (MoAbs) in solid-phase ELISA it was found that influenza virus A/Hong Kong/1/68 (H3N2) mutants resistant to the antiviral compound mopyridone as compared to the mopyridone-sensitive mutant manifested significant changes in the antigenic structure (sites 1A, 2 and 3) of M1 protein. No differences in M1 were found between rimantadine-resistant and rimantadine-sensitive mutants of influenza virus A(H3N2).
Galabov
A S
AS
Institute of Microbiology, Bulgarian Academy of Sciences, Sofia.
Khristova
M L
ML
Uzunov
S
S
Wassilewa
L
L
Bucher
D J
DJ
Kharitonenkov
I G
IG
D000818:Animals; D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral / Q000276:immunology; D000998:Antiviral Agents / Q000494:pharmacology*; D002642:Chick Embryo; D004352:Drug Resistance, Microbial; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000276:immunology; D009980:Influenza A virus / Q000187:drug effects / Q000276:immunology*; D009154:Mutation; D011744:Pyrimidinones / Q000494:pharmacology*; D012299:Rimantadine / Q000494:pharmacology; D014763:Viral Matrix Proteins / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000914:Antibodies, Viral; D000956:Antigens, Viral; D000998:Antiviral Agents; D000939:Epitopes; C031540:M-protein, influenza virus; C488936:M1 protein, Influenza A virus; D011744:Pyrimidinones; D014763:Viral Matrix Proteins; D012299:Rimantadine; C047314:1-morpholinomethyl-tetrahydro-1(1H)-pyrimidinone