Method for systemic anaphylactic challenge in the rat using subplantar route.
Intravenous injection of antigen is the fastest and most effective way of eliciting anaphylactic shock in previously sensitized rats. When intravenous injection is difficult or undesirable, subplantar challenge is a preferable alternative to the intraperitoneal route.
Levine
S
S
Nathan S. Kline Institute for Psychiatric Research, Orangeburg, NY 10962.
Saltzman
A
A
D000536:Aluminum Hydroxide / Q000276:immunology; D000707:Anaphylaxis / Q000209:etiology*; D000818:Animals; D004195:Disease Models, Animal; D005528:Foot; D005620:Freund's Adjuvant; D007271:Injections, Intradermal; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D007279:Injections, Subcutaneous; D010047:Ovalbumin / Q000008:administration & dosage* / Q000276:immunology; D010567:Pertussis Vaccine / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew / Q000276:immunology*; D005719:gamma-Globulins / Q000008:administration & dosage* / Q000276:immunology
D010567:Pertussis Vaccine; D005719:gamma-Globulins; D000536:Aluminum Hydroxide; D010047:Ovalbumin; D005620:Freund's Adjuvant