Loco-regional treatment for esophageal cancer with bleomycin adsorbed to activated carbon particles.
Bleomycin (BLM) was adsorbed to activated carbon particles (BLM-CH), and the effective distribution of BLM in the regional lymph nodes and surrounding connective tissues was studied in 10 patients with mid-thoracic esophageal cancer. One ml of BLM-CH was injected submucosally into the tumor and normal esophageal wall endoscopically one or three days prior to operation. BLM activity was found both in the lymph nodes and connective tissues, not only in the mediastinal region but in the cervical and abdominal regions. Degenerative or inflammatory changes were microscopically observed in 6 out of 23 lymph nodes with metastatic foci. BLM-CH could be a useful tool in targeting chemotherapy for esophageal cancer.
Natsugoe
S
S
First Department of Surgery, Kagoshima University School of Medicine, Japan.
Aikou
T
T
Shimada
M
M
Kumanohoso
T
T
Shimazu
H
H
Nakamura
K
K
D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002244:Carbon; D003238:Connective Tissue / Q000378:metabolism; D004938:Esophageal Neoplasms / Q000188:drug therapy*; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008198:Lymph Nodes / Q000378:metabolism; D008297:Male; D008875:Middle Aged
D001761:Bleomycin; D002244:Carbon