title: Inhibitory effects of (4-alkoxy-2, 3, 6-trimethylphenyl) glycopyranosides on histamine release induced by antigen-antibody reaction.
abstract: The inhibitory effects of newly synthesized 4-alkoxy-2, 3, 6-trimethylphenyl D-glycopyranosides on histamine release induced by antigen-antibody reaction were examined. Among the compounds tested, 4-hexoxy-2, 3, 6-trimethylphenyl alpha-D-mannopyranoside exhibited the strongest inhibitory effect. Furthermore, 4-hexoxy-2, 3, 6-trimethylphenyl alpha-D-glucopyranoside and alpha-D-galactopyranoside markedly inhibited antigen-induced histamine release, and their activities were more potent than those of the corresponding beta-anomers. These results suggest that these compounds may possess excellent anti-allergic activities.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors.forename: T C
authors.initials: TC
authors.lastname: Wang
authors.forename: H
authors.initials: H
authors.lastname: Kakegawa
authors.forename: S
authors.initials: S
authors.lastname: Nakaishi
authors.forename: H
authors.initials: H
authors.lastname: Matsumoto
authors.forename: T
authors.initials: T
authors.lastname: Satoh
mesh_terms: D000818:Animals; D000937:Antigen-Antibody Reactions / Q000502:physiology*; D002478:Cells, Cultured; D006027:Glycosides / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects* / Q000502:physiology; D051381:Rats
chemical_list: D006027:Glycosides