title: Relief of metastatic biliary obstruction by stent placement: is it worthwhile?
abstract: Twenty-one patients undergoing stent placement for extra-hepatic biliary obstruction by metastatic disease were reviewed. Primary tumours (colorectal 8, stomach 4, breast 2, ovary 2, others 5) had been diagnosed 13 months (median) before presentation with bile duct obstruction, which was at the porta hepatis or common hepatic duct in 14 patients and in the common bile duct in seven. Endoscopic stent placement was achieved in 14 out of 20 patients in whom it was attempted. A percutaneous trans-hepatic procedure was necessary in five patients. Two patients could not be stented. Median survival was 5 months (range 1 month to 6 years) in patients stented successfully but only 1 month (2 weeks to 3 months) in unsuccessful cases (P < 0.01). Nine patients survived more than 4 months. Patients with proximal obstruction fared less well than those with distal obstruction; they required more procedures and survived for shorter periods (median 1 month versus 5 months, P < 0.05). Worthwhile palliation is afforded to almost half these patients by endoscopic stent placement and individual patients may achieve prolonged, symptom-free survival.
authors.affiliation: Department of Surgery, University Hospital of South Manchester, UK.
authors.forename: I D
authors.initials: ID
authors.lastname: Anderson
authors.forename: J M
authors.initials: JM
authors.lastname: Manson
authors.forename: D F
authors.initials: DF
authors.lastname: Martin
authors.forename: D E
authors.initials: DE
authors.lastname: Tweedle
mesh_terms: D000328:Adult; D000368:Aged; D001650:Bile Duct Neoplasms / Q000150:complications* / Q000401:mortality / Q000556:secondary; D001943:Breast Neoplasms / Q000473:pathology; D002779:Cholestasis / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D015179:Colorectal Neoplasms / Q000473:pathology; D004322:Drainage; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000473:pathology; D010166:Palliative Care; D015607:Stents / Q000009:adverse effects; D013274:Stomach Neoplasms / Q000473:pathology; D015996:Survival Rate