[Tumoral vascular density in breast tumors and their effect on recurrence-free survival].
Angiogenesis quantitation of 106 patients with primary breast cancer and 35 patients with adenofibroma of the breast was compared and examined to its prognostic relevance for five-years disease-free survival in breast cancer patients. Immunocytochemical staining for Factor VIII-related antigen was performed to outline vascular endothelium. We found a significant higher vessel density in breast cancer patients who experienced recurrence (17.4) than in those with no recurrence (9.4) or with adenofibroma (8.7) [p < 0.0001]. The probability of five-years recurrence-free survival for patients with a primary tumor of high vessel density was at 52.3% and 86.4% for tumors of low microvessel density (p < 0.0011). Microvessel density proved to be an independent prognostic factor for breast cancer recurrence in the Cox-Model (relative risk 2.047, p = 0.0002).
Obermair
A
A
Universitäts-Frauenklinik, Abteilung Geburtshilfe und Gynäkologie, Allgemeines Krankenhaus Wien.
Czerwenka
K
K
Kurz
C
C
Kaider
A
A
Sevelda
P
P
D014408:Biomarkers, Tumor / Q000032:analysis; D001940:Breast / Q000098:blood supply* / Q000473:pathology; D001943:Breast Neoplasms / Q000098:blood supply* / Q000401:mortality / Q000628:therapy; D002196:Capillaries / Q000473:pathology; D003131:Combined Modality Therapy; D005260:Female; D018226:Fibroadenoma / Q000098:blood supply* / Q000401:mortality / Q000628:therapy; D006801:Humans; D008207:Lymphatic Metastasis; D015411:Mastectomy, Modified Radical; D015412:Mastectomy, Segmental; D009367:Neoplasm Staging; D009389:Neovascularization, Pathologic / Q000473:pathology*; D011379:Prognosis; D011446:Prospective Studies; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D015996:Survival Rate; D014841:von Willebrand Factor / Q000032:analysis
D014408:Biomarkers, Tumor; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D014841:von Willebrand Factor