title: The septum pellucidum and spatial ability of children with optic nerve hypoplasia.
abstract: Animal studies suggest that spatial skills are dependent on an intact septum pellucidum. This theory was tested by comparing patients who were visually impaired due to bilateral optic nerve hypoplasia: 13 with a septum pellucidum were compared with six children without a septum pellucidum. There was no difference in spatial ability. The finding of an absent septum pellucidum may only indicate the timing of a congenital brain insult, and it cannot be used to predict specific clinical, neuroendocrinological, cognitive or spatial abnormalities.
authors.affiliation: Newcomen Centre, Guy's Hospital, London.
authors.forename: M
authors.initials: M
authors.lastname: Groenveld
authors.forename: K R
authors.initials: KR
authors.lastname: Pohl
authors.forename: H
authors.initials: H
authors.lastname: Espezel
authors.forename: J E
authors.initials: JE
authors.lastname: Jan
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis / Q000209:etiology; D005260:Female; D006801:Humans; D007360:Intelligence; D007361:Intelligence Tests; D008297:Male; D009900:Optic Nerve / Q000002:abnormalities*; D009901:Optic Nerve Diseases / Q000150:complications* / Q000175:diagnosis; D010468:Perceptual Disorders / Q000209:etiology; D012688:Septum Pellucidum / Q000002:abnormalities* / Q000502:physiology; D013028:Space Perception; D014786:Vision Disorders / Q000209:etiology