title: Resistance to atracurium: Wegener's granulomatosis--a case report.
abstract: Few previous reports clarified that patients with an increased alpha 1 globulin fraction in their serum protein electrophoresis, will have resistance to the neuromuscular block of atracurium. Having a patient with diagnosis of Wegener's granulomatosis and a marked elevation of alpha 1 globulin fraction in her electrophoresis, we took this opportunity to monitor the neuromuscular block of atracurium. The data obtained, confirm previous studies showing that patients with a marked increase in alpha 1 globulin fraction may have a resistance to the action of atracurium.
authors.affiliation: Department of Anaesthesia, Medical Faculty of KTU, Trabzon, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Lüleci
authors.forename: G
authors.initials: G
authors.lastname: Aktürk
authors.forename: N
authors.initials: N
authors.lastname: Kalaç
mesh_terms: D001279:Atracurium / Q000008:administration & dosage / Q000494:pharmacology*; D004351:Drug Resistance; D005260:Female; D014890:Granulomatosis with Polyangiitis / Q000097:blood / Q000503:physiopathology*; D006801:Humans; D009469:Neuromuscular Junction / Q000187:drug effects* / Q000503:physiopathology; D009961:Orosomucoid / Q000032:analysis; D000511:alpha-Macroglobulins / Q000032:analysis
chemical_list: D009961:Orosomucoid; D000511:alpha-Macroglobulins; D001279:Atracurium