Nonselective cation channels in exocrine gland cells.
The nonselective cation channel has been described in a wide variety of nonexcitable cells. However even in such closely related tissues as the pancreatic acinar cell and the lacrimal acinar cell, which both possess a superficially similar channel, recent work has shown fundamental differences in channel regulation (Sasaki and Gallacher, 1992; Thorn and Petersen, 1992). These differences are a reflection of a diverse function of the nonselective channel in different tissues.
Thorn
P
P
Physiological Laboratory, University of Liverpool, U.K.
Petersen
O H
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D000109:Acetylcholine / Q000494:pharmacology; D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D002412:Cations / Q000378:metabolism; D002460:Cell Line; D002766:Cholecystokinin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D004492:Edetic Acid / Q000494:pharmacology; D005088:Exocrine Glands / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D007765:Lacrimal Apparatus / Q000187:drug effects / Q000502:physiology; D008564:Membrane Potentials / Q000187:drug effects; D010179:Pancreas / Q000502:physiology; D015290:Second Messenger Systems; D013363:Submandibular Gland / Q000502:physiology
D002412:Cations; D007473:Ion Channels; D000255:Adenosine Triphosphate; D002766:Cholecystokinin; D004492:Edetic Acid; D000242:Cyclic AMP; D000109:Acetylcholine; D002118:Calcium