Anti-HIV effect of gramicidin in vitro: potential for spermicide use.
Gramicidin, cation channel forming ionophore with antibacterial properties, was studied in vitro for inhibition of human immunodeficiency virus (HIV) infection of MT-4 lymphocytes. Effective antiviral concentrations required for complete HIV inactivation were three orders of magnitude lower than 10 micrograms/ml cytotoxic dose. Gramicidin, routinely used as a contraceptive agent, should be considered for clinical application as a spermicide with antiviral activity.
Bourinbaiar
A S
AS
Department of Biochemistry, New York University Medical Center, New York 10016.
Krasinski
K
K
Borkowsky
W
W
D000595:Amino Acid Sequence; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D006096:Gramicidin / Q000494:pharmacology*; D006678:HIV / Q000187:drug effects*; D016655:HIV Core Protein p24 / Q000032:analysis; D006801:Humans; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D008969:Molecular Sequence Data; D013089:Spermatocidal Agents
D016655:HIV Core Protein p24; D013089:Spermatocidal Agents; D006096:Gramicidin