[How tumors abuse their host: the transcription factor c-ets1 and the regulation of tumor angiogenesis or invasion].
During their progression, epithelial tumors induce a stromal reaction essential for their development and for metastasis. In situ hybridization studies have revealed that the protooncogene c-ets1 is expressed in endothelial cells at the beginning tumor angiogenesis, and in stromal fibroblasts surrounding invasive tumors. C-ets1 encodes a transcription factor that may activate the transcription of genes encoding collagenase 1, stromelysin 1 and urokinase plasminogen activator, proteases involved in extracellular matrix degradation. A working hypothesis is that c-Ets1 takes part in regulating invasive processes by controlling the transcription of these genes. Experimental evidences that may confirm this hypothesis will be discussed.
Vandenbunder
B
B
Laboratoire d'Oncologie Moléculaire, CNRS URA 1160, Institut Pasteur de Lille.
Wernert
N
N
Stéhelin
D
D
D000818:Animals; D001483:Base Sequence; D002277:Carcinoma / Q000235:genetics*; D017364:Collagenases / Q000235:genetics; D004273:DNA, Neoplasm / Q000235:genetics*; D015972:Gene Expression Regulation, Neoplastic / Q000235:genetics*; D006801:Humans; D019278:Matrix Metalloproteinase 3; D008666:Metalloendopeptidases / Q000235:genetics; D008969:Molecular Sequence Data; D009361:Neoplasm Invasiveness / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D009389:Neovascularization, Pathologic / Q000235:genetics*; D011200:Poultry; D050784:Proto-Oncogene Protein c-ets-1; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors / Q000235:genetics*; D014568:Urokinase-Type Plasminogen Activator / Q000235:genetics
D004273:DNA, Neoplasm; C494041:ETS1 protein, human; D009363:Neoplasm Proteins; D050784:Proto-Oncogene Protein c-ets-1; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors; D014568:Urokinase-Type Plasminogen Activator; D017364:Collagenases; D008666:Metalloendopeptidases; D019278:Matrix Metalloproteinase 3