title: Safety aspects of non-depolarizing neuromuscular blocking agents with special reference to rocuronium bromide.
abstract: The safety of neuromuscular relaxants can be assessed according to their cardiovascular and autonomic effects, their liability to release histamine, their tendency to cause anaphylactic/anaphylactoid reactions, their effect on cholinesterase, on intra-ocular and intracranial pressure, their tendency to cumulation and their reversibility. Any adverse effects of metabolites are also potential problems. Against these standards, rocuronium may have some mild vagolytic activity. Apart from that, its safety profile is indistinguishable from that of vecuronium.
authors.affiliation: Department of Anaesthetics, Queen's University of Belfast, Northern Ireland.
authors.forename: R K
authors.initials: RK
authors.lastname: Mirakhur
mesh_terms: D000732:Androstanols / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D000818:Animals; D002800:Cholinesterase Inhibitors / Q000494:pharmacology; D006439:Hemodynamics / Q000187:drug effects; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D003473:Neuromuscular Nondepolarizing Agents / Q000009:adverse effects* / Q000037:antagonists & inhibitors; D000077123:Rocuronium
chemical_list: D000732:Androstanols; D002800:Cholinesterase Inhibitors; D003473:Neuromuscular Nondepolarizing Agents; D000077123:Rocuronium