title: Effect of cionin on histamine and acid secretion by the perfused rat stomach.
abstract: BACKGROUND
  The protochordean octapeptide cionin is structurally a hybrid of mammalian cholecystokinin (CCK) and gastrin. An earlier study has shown that cionin in mammals stimulates gallbladder contraction and gastric somatostatin release, similarly to CCK-8.
  
  
  METHODS
  In the present study we examined the effect of cionin on histamine release and acid secretion of the stomach, both effects being mediated by CCK-B/gastrin receptors.
  
  
  RESULTS
  Cionin induced a concentration-dependent increase in histamine release and acid secretion in the isolated, vascularly perfused rat stomach, detectable at a concentration of 4 pM and reaching a maximum at a concentration of 512 pM. The CCK-B/gastrin receptor antagonist L 365,260 abolished the stimulating effect of cionin on both histamine release and acid secretion, whereas the CCK-A receptor antagonist L 364,718 only had a faint effect.
  
  
  CONCLUSIONS
  Cionin is a potent and efficient stimulator of gastric histamine release and acid secretion interacting via a CCK-B receptor.
authors.affiliation: Dept. of Surgery, Trondheim University Hospital, Norway.
authors.forename: R
authors.initials: R
authors.lastname: Mårvik
authors.forename: A H
authors.initials: AH
authors.lastname: Johnsen
authors.forename: J F
authors.initials: JF
authors.lastname: Rehfeld
authors.forename: A
authors.initials: A
authors.lastname: Sandvik
authors.forename: H L
authors.initials: HL
authors.lastname: Waldum
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism*; D005753:Gastric Mucosa / Q000378:metabolism*; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000494:pharmacology*; D010671:Phenylurea Compounds; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors
chemical_list: D001570:Benzodiazepinones; D009479:Neuropeptides; D010671:Phenylurea Compounds; D011949:Receptors, Cholecystokinin; C063059:cionin; C058121:L 365260