Antimutagenicity of lemon grass (Cymbopogon citratus Stapf) to various known mutagens in salmonella mutation assay.
Lemon grass (Cymbopogon citratus Stapf) was extracted with 80% ethanol. The extract was not found to be mutagenic in the Salmonella mutation test with or without metabolic activation. However, the extract was found to possess antimutagenic properties towards chemical-induced mutation in Salmonella typhimurium strains TA98 and TA100. Mutagenicity of AFB1, Trp-P-1, Trp-P-2, Glu-P-1, Glu-P-2, IQ, MNNG and AF-2, was inhibited by the extract of lemon grass in a dose-dependent manner, but no effect was found on the mutagenic activity of benzo[a]pyrene.
Vinitketkumnuen
U
U
Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand.
Puatanachokchai
R
R
Kongtawelert
P
P
Lertprasertsuke
N
N
Matsushima
T
T
D016587:Antimutagenic Agents / Q000494:pharmacology*; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D009152:Mutagenicity Tests; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D006109:Poaceae; D012485:Salmonella typhi / Q000187:drug effects
D016587:Antimutagenic Agents; D010936:Plant Extracts