title: Intestinal transplantation at the University of Pittsburgh.
abstract: Our experience with clinical intestinal transplantation under FK 506 immunosuppression showed that 50% of the recipients were able to be independent from TPN after transplantation, but 10% require partial TPN with functioning grafts, 10% needed total TPN after graft removal, and 30% of the recipients died postoperatively, mostly from sepsis due to severe graft rejection. For further improvement in patient survival and in the quality of life for patients after intestinal transplantation, it is mandatory to establish a new strategy for treatment and prevention of graft rejection and systemic infection.
authors.affiliation: Pittsburgh Transplantation Institute, University of Pittsburgh Medical Center, Pennsylvania.
authors.forename: S
authors.initials: S
authors.lastname: Todo
authors.forename: A
authors.initials: A
authors.lastname: Tzakis
authors.forename: J
authors.initials: J
authors.lastname: Reyes
authors.forename: K
authors.initials: K
authors.lastname: Abu-Elmagd
authors.forename: H
authors.initials: H
authors.lastname: Furukawa
authors.forename: B
authors.initials: B
authors.lastname: Nour
authors.forename: Z
authors.initials: Z
authors.lastname: Kadry
authors.forename: J
authors.initials: J
authors.lastname: Fung
authors.forename: T E
authors.initials: TE
authors.lastname: Starzl
mesh_terms: D000328:Adult; D002675:Child, Preschool; D005500:Follow-Up Studies; D006084:Graft Rejection / Q000517:prevention & control; D006085:Graft Survival; D006801:Humans; D007422:Intestines / Q000637:transplantation*; D016031:Liver Transplantation; D010289:Parenteral Nutrition, Total; D011788:Quality of Life; D012189:Retrospective Studies; D018805:Sepsis; D015996:Survival Rate; D016559:Tacrolimus / Q000627:therapeutic use; D013997:Time Factors; D014180:Transplantation / Q000379:methods / Q000401:mortality
chemical_list: D016559:Tacrolimus