title: [Encephalitis lethargica].
abstract: We report the case of a 34-year old patient who first complained of fever, confusion and transient ophthalmoplegia and then developed akinetic mutism, frontal lobe, pyramidal tract and extrapyramidal signs. Clinical and electrophysiological data support a diagnosis of encephalitis lethargica. Magnetic resonance imaging showed hyperintensive lesions in various brain regions. The patient responded to corticosteroid treatment. Two years after the onset of the first clinical signs he had recovered completely and today, after 5 years, he shows no sign of disease.
authors.affiliation: Fondazione Istituto Neurologico C. Mondino, Pavia, Italien.
authors.forename: L
authors.initials: L
authors.lastname: Barletta
authors.forename: F
authors.initials: F
authors.lastname: Simonetti
authors.forename: J
authors.initials: J
authors.lastname: Karau
authors.forename: R
authors.initials: R
authors.lastname: Manni
authors.forename: C
authors.initials: C
authors.lastname: Uggetti
authors.forename: T E
authors.initials: TE
authors.lastname: Poloni
authors.forename: P
authors.initials: P
authors.lastname: Pergami
authors.forename: F
authors.initials: F
authors.lastname: Savoldi
authors.forename: M
authors.initials: M
authors.lastname: Ceroni
mesh_terms: D000328:Adult; D002540:Cerebral Cortex / Q000473:pathology / Q000503:physiopathology; D004569:Electroencephalography / Q000187:drug effects; D004671:Encephalitis, Arbovirus / Q000175:diagnosis* / Q000188:drug therapy / Q000503:physiopathology; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D009460:Neurologic Examination / Q000187:drug effects; D010301:Parkinson Disease, Postencephalitic / Q000473:pathology / Q000503:physiopathology
chemical_list: D008775:Methylprednisolone