title: Mutagenicity of K-region oxides and imines of chrysene, benzo[c]phenanthrene and benzo[g]chrysene in Salmonella typhimurium.
abstract: The K-region oxides and imines of chrysene, benzo[c]phenanthrene and benzo[g]chrysene were investigated for mutagenicity in Salmonella typhimurium TA98 and TA100, using two different exposure media. All six compounds were mutagenic under all four experimental conditions. The imines were 17-3800 times more potent than the corresponding oxides. Omission of KCl (125 mM) from the exposure medium resulted in enhanced mutagenic effects. The enhancement was stronger in strain TA98 (3.1-5.2-fold) than in strain TA100 (1.3-2.5-fold), suggesting an influence on the bacteria rather than on the chemicals.
authors.affiliation: Department of Toxicology, Johannes Gutenberg University, Mainz, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Glatt
authors.forename: E
authors.initials: E
authors.lastname: Abu-Shqara
authors.forename: R G
authors.initials: RG
authors.lastname: Harvey
authors.forename: J
authors.initials: J
authors.lastname: Blum
mesh_terms: D001388:Aziridines / Q000633:toxicity*; D002911:Chrysenes / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004852:Epoxy Compounds / Q000633:toxicity*; D007097:Imines / Q000633:toxicity; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010616:Phenanthrenes / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
chemical_list: D001388:Aziridines; D002911:Chrysenes; D004852:Epoxy Compounds; D007097:Imines; D009153:Mutagens; D010616:Phenanthrenes; C088285:chrysene-5,6-imine; C088286:benzo(g)chrysene-9,10-imine; C050403:chrysene-5,6-oxide; C052681:benzo(c)phenanthrene 5,6-oxide; C088287:benzo(c)phenanthrene-5,6-imine; C002615:benzo(c)phenanthrene