Human immunodeficiency virus type 1 (HIV-1) and human hematopoietic progenitor cells.
Besides a progressive depletion of CD4+ T-lymphocytes, other peripheral blood cytopenias, (granulocytopenia, anemia and thrombocytopenia) are frequently observed in HIV-1 seropositive individuals, especially in patients with overt AIDS. Various experimental evidences suggest that HIV-1 could play a direct role in the pathogenesis of HIV-1 related peripheral blood cytopenias, affecting the survival/proliferation capacity of hematopoietic progenitors. CD34+ human hematopoietic progenitors, however, are substantially not susceptible to HIV-1 infection either in vitro and in vivo and their defects seem rather related to an alteration of bone marrow and peripheral blood microenvironments due to the presence of soluble HIV-1 specific products.
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Institute of Microbiology, University of Bologna, St. Orsola General Hospital, Italy.
Furlini
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Zauli
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La Placa
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D000163:Acquired Immunodeficiency Syndrome / Q000097:blood* / Q000150:complications / Q000473:pathology*; D015703:Antigens, CD / Q000032:analysis*; D018952:Antigens, CD34; D001853:Bone Marrow / Q000473:pathology*; D002454:Cell Differentiation; D002470:Cell Survival; D006679:HIV Seropositivity / Q000097:blood* / Q000473:pathology; D015497:HIV-1; D006402:Hematologic Diseases / Q000150:complications; D006412:Hematopoietic Stem Cells / Q000473:pathology*; D006801:Humans
D015703:Antigens, CD; D018952:Antigens, CD34