Comparative study on cytogenetic damage induced by homo-aza-steroidal esters in human lymphocytes.
The effect of P[N,N-bis(2-chloroethyl)amino]phenylacetate esters of 3 beta-hydroxy-N-methyl-17 alpha-aza-D-homo-5 alpha-androstan-17-one (compound 3) and 3 beta-hydroxy-17 alpha-aza-D-homo-5 alpha-androstane (compound 2) on sister-chromatid exchange (SCE) frequencies and on human lymphocytes proliferation kinetics was studied. The results are compared with those of the P[N,N-bis(2-chloroethyl)amino]phenylacetate esters of 3 beta-hydroxy-17 alpha-aza-D-homo-5 alpha-androstan-17-one (compound 1). All compounds were found to be active in inducing markedly increased SCE rates and cell division delays. A correlation between potency for SCE induction, effectiveness in cell division delay and previously established antitumour activity of these compounds was observed.
Mourelatos
D
D
Department of General Biology and Genetics, Faculty of Medicine, Aristotelian University, Thessaloniki, Greece.
Papageorgiou
A
A
Boutis
L
L
Catsoulacos
P
P
D000731:Androstanes / Q000633:toxicity*; D000970:Antineoplastic Agents / Q000633:toxicity*; D001378:Azasteroids / Q000633:toxicity*; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects*; D009153:Mutagens / Q000633:toxicity*; D009588:Nitrogen Mustard Compounds / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects
D000731:Androstanes; D000970:Antineoplastic Agents; D001378:Azasteroids; D009153:Mutagens; D009588:Nitrogen Mustard Compounds; C077967:3-hydroxy-17-aza-D-homoandrostan-4-N,N-bis(2-chloroethyl)aminophenylacetate; C077969:3-hydroxy-N-methyl-17-aza-D-homoandrostan-17-one-4-N,N-bis(2-chloroethyl)aminophenylacetate; C017888:NSC 290205