title: [Significance of total dose of IFN in the treatment of chronic hepatitis C].
abstract: Two hundred thirteen patients with chronic hepatitis C were treated with IFN for 4 to 52 weeks and complete response, in which ALT levels sustained within the normal value after more than 6 months following IFN treatment, was achieved in only 10% of the patients treated with less than 300 MU of IFN, whereas it was 42% in those treated with more than 500 MU, hence the total amount of IFN is important in the treatment of chronic hepatitis C. The duration of the treatment (4 to 52 weeks) made little difference in the response when more than 500 MU of IFN were administered.
authors.affiliation: First Department of Medicine, Chiba University School of Medicine.
authors.forename: F
authors.initials: F
authors.lastname: Imazeki
authors.forename: O
authors.initials: O
authors.lastname: Yokosuka
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D002908:Chronic Disease; D006526:Hepatitis C / Q000628:therapy*; D006801:Humans; D007372:Interferons / Q000008:administration & dosage*; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000097:blood; D016896:Treatment Outcome
chemical_list: D015415:Biomarkers; D012367:RNA, Viral; D007372:Interferons; D000410:Alanine Transaminase