title: t(1;19) without detectable E2A rearrangements in two t(14;18)-positive lymphoma/leukemia cases.
abstract: Translocation t(1;19)(q23;p13) plays a crucial role in the pathogenesis of childhood pre-B cell leukemia and results in the formation of a fusion gene E2A-PBX1 that encodes a hybrid transcription factor with oncogenic potential. Here we describe two cases, one follicular lymphoma and one acute lymphoblastic leukemia/lymphoma, characterized by a complex karyotype including t(14;18), t(8;14), as well as t(1;19). Molecular studies in both cases failed to show rearrangements of the E2A gene. These results suggest that the t(1;19) found as a secondary chromosome change in t(14;18)-positive lymphoma/leukemia might be a molecular variant of the t(1;19) that is typical of childhood pre-B cell leukemia.
authors.affiliation: Center for Human Genetics, University of Leuven, Belgium.
authors.forename: I
authors.initials: I
authors.lastname: Wlodarska
authors.forename: M
authors.initials: M
authors.lastname: Stul
authors.forename: C
authors.initials: C
authors.lastname: De Wolf-Peeters
authors.forename: G
authors.initials: G
authors.lastname: Verhoef
authors.forename: C
authors.initials: C
authors.lastname: Mecucci
authors.forename: J J
authors.initials: JJ
authors.lastname: Cassiman
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D015139:Blotting, Southern; D002051:Burkitt Lymphoma / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D002888:Chromosomes, Human, Pair 19; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008224:Lymphoma, Follicular / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D051820:TCF Transcription Factors; D058125:Transcription Factor 7-Like 1 Protein; D014157:Transcription Factors; D014178:Translocation, Genetic
chemical_list: D004268:DNA-Binding Proteins; D051820:TCF Transcription Factors; C544912:TCF7L1 protein, human; D058125:Transcription Factor 7-Like 1 Protein; D014157:Transcription Factors