Chemically-induced aneuploidy in mammalian oocytes.
The ability of certain chemicals to elevate the frequency of aneuploidy above spontaneous levels in mammalian experimental models prompts the concern that a similar situation might exist in humans. Validation of experimental models for aneuploidy studies is in progress since there is much to be learned about the causes and mechanisms of chemically-induced aneuploidy. Several biological variables have been shown to influence the results from aneuploidy assays. In this review, we examine these variables as they relate to female germ cell aneuploid assays. Also, we have found that the aneuploidy results obtained from different cell types, sexes, and experimental models cannot necessarily be expected to agree due to certain anatomic and physiologic differences and the end points measured.
Mailhes
J B
JB
Department of Obstetrics and Gynecology, Louisiana State University Medical Center, Shreveport 71130.
Marchetti
F
F
D000782:Aneuploidy; D000818:Animals; D002970:Cleavage Stage, Ovum / Q000187:drug effects; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009865:Oocytes / Q000187:drug effects*
D009153:Mutagens