Action of intraduodenal ethanol on exocrine pancreatic secretion in chronic alcoholic rats fed with different diets.
The effects of diet composition (equilibrated and fat- and protein-rich) in combination with chronic ethanol ingestion on pancreatic exocrine secretion were studied in rats after a 7-month treatment period, also analyzing under these experimental conditions the acute effects of intraduodenal administration of 20% ethanol. Chronic consumption of ethanol affected pancreatic flow but its acute administration stimulated the secretion of fluid, especially in control rats. Total protein secretion is depressed in all rats receiving ethanol as fluid, but this was increased when rats drank water. Amylase activity depends on carbohydrate levels, decreased with fat and protein-rich diet but not with ethanol ingestion. Diet composition by itself did not affect specific trypsin activity but this increased significantly when a fat- and protein-rich diet was administered together with ethanol. Trypsin activity remained unchanged when ethanol was perfused into the duodenum in animals receiving ethanol chronically.
de Dios
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Departamento de Fisiología y Farmacología, Facultad de Biología, Universidad de Salamanca, Spain.
Gallego
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Manso
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MA
D000437:Alcoholism / Q000378:metabolism* / Q000473:pathology; D000681:Amylases / Q000378:metabolism; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004032:Diet; D004386:Duodenum; D004435:Eating; D002149:Energy Intake; D000431:Ethanol / Q000008:administration & dosage / Q000494:pharmacology*; D006128:Growth / Q000187:drug effects; D007441:Intubation, Gastrointestinal; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010189:Pancreatic Juice / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014357:Trypsin / Q000378:metabolism
D000431:Ethanol; D000681:Amylases; D014357:Trypsin