Altered monamine metabolism in caudate-putamen of iron-deficient rats.
The effect of iron deficiency on brain monoamine metabolism using in vivo microdialysis techniques has not been previously reported. We, therefore, examined the monoamines, dopamine and norepinephrine, and their metabolites at steady state by in vivo microdialysis in rat brain caudate-putamen in 11-week-old iron-deficient anemic (hemoglobin < 7 g/dl) and control rats (Hb > 14 g/dl). Caudate-putamen dopamine (DA), dihydroxyphenyl acetic acid (DOPAC), and homovanillic acid (HVA) concentrations were increased by 53%, 57%, and 30% (p < 0.001), respectively, in iron-deficient rats in samples collected over a 4-h period. While diminished numbers of D2 receptors have been previously reported, the present findings suggest an additional defect in monoamine uptake and catabolism.
Beard
J L
JL
Nutrition Department, Pennsylvania State University, University Park 16802.
Chen
Q
Q
Connor
J
J
Jones
B C
BC
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D015306:Biogenic Monoamines / Q000378:metabolism*; D001835:Body Weight / Q000502:physiology; D002421:Caudate Nucleus / Q000378:metabolism*; D004032:Diet; D006719:Homovanillic Acid / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D000090463:Iron Deficiencies; D008297:Male; D017551:Microdialysis; D009929:Organ Size / Q000502:physiology; D011699:Putamen / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D015306:Biogenic Monoamines; D015102:3,4-Dihydroxyphenylacetic Acid; D006897:Hydroxyindoleacetic Acid; D006719:Homovanillic Acid