Signaling mechanisms in thymocyte selection.
The processes known as positive and negative selection that determine the fate of T and B cells depend on finely tuned interactions between the T-cell receptor complex, CD4 or CD8 co-receptors, and a peptide-MHC complex. New work indicates that the avidity of this interaction is critical in the determination of its outcome. The effects of these interactions on developing thymocytes are also a function of the unique activation properties with which thymocytes are programmed just before they undergo selection.
Rothenberg
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Division of Biology, California Institute of Technology, Pasadena 91125.
D000818:Animals; D000954:Antigens, Surface / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D008024:Ligands; D011518:Proto-Oncogene Proteins / Q000502:physiology; D019253:Proto-Oncogene Proteins c-bcl-2; D011948:Receptors, Antigen, T-Cell / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000166:cytology*; D013950:Thymus Gland / Q000166:cytology* / Q000254:growth & development*; D019014:fas Receptor
D000954:Antigens, Surface; D008024:Ligands; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D011948:Receptors, Antigen, T-Cell; D011956:Receptors, Cell Surface; D019014:fas Receptor