The extent of amyloid deposition in brain in patients with Down's syndrome does not depend upon the apolipoprotein E genotype.
The extent of deposition of amyloid beta protein (A beta) was investigated in 20 elderly patients with Down's syndrome, using the end-specific monoclonal antibodies BC05 and BA27 to detect the presence of A beta 42(43) and A beta 40 (respectively), and related to apolipoprotein E (ApoE) genotype. No significant differences in the amount of A beta deposited in the brain, either as A beta 42(43) or A beta 40, were noted in patients possessing an ApoE E4 allele, compared to those without. Patients with an ApoE E4 allele in general died at an earlier age than those with only ApoE E3 alleles, the latter in turn being outlived by those with an ApoE E2 allele. In Down's syndrome therefore, ApoE may influence the timing of onset, or the rate of progression, of disease but without affecting the type or total amount of pathology accumulated.
Mann
D M
DM
Department of Pathological Sciences, University of Manchester, UK.
Pickering-Brown
S M
SM
Siddons
M A
MA
Iwatsubo
T
T
Ihara
Y
Y
Asami-Odaka
A
A
Suzuki
N
N
D000368:Aged; D000544:Alzheimer Disease; D016564:Amyloid beta-Protein Precursor / Q000378:metabolism*; D000911:Antibodies, Monoclonal / Q000276:immunology; D001057:Apolipoproteins E / Q000378:metabolism*; D001921:Brain / Q000378:metabolism; D004314:Down Syndrome / Q000209:etiology* / Q000378:metabolism*; D005625:Frontal Lobe / Q000378:metabolism; D005838:Genotype; D006801:Humans; D008875:Middle Aged
D016564:Amyloid beta-Protein Precursor; D000911:Antibodies, Monoclonal; D001057:Apolipoproteins E