title: Discrimination between demented patients and normals based on topographic EEG slow wave activity: comparison between z statistics, discriminant analysis and artificial neural network classifiers.
abstract: The topographic distributions of absolute delta and theta powers were used to classify demented patients and normals by means of z statistics, discriminant analysis and artificial neural networks (NN). The data were taken from two psychopharmacological studies in mildly to moderately demented patients (111 and 96 patients for studies I and II, respectively) and from 56 normal healthy controls. All patients were diagnosed according to DSM-III criteria and were free of medication for at least 2 weeks. The NN used was a strictly layered feed-forward network with complete connections. The z-transformed absolute power values in the combined delta and theta frequency range at 17 electrodes, recorded in a 3 min vigilance-controlled EEG with eyes closed, were used as input. After having trained the NN successfully by backpropagating of errors, the generalization test with independent data results in a classification performance of 90% determined by "relative operating characteristic" analysis. The NN out-performed z statistics and discriminant analysis. This high percentage of correct classifications may justify the development of further application of NNs based on topographic EEG data.
authors.affiliation: Department of Psychiatry, University of Vienna, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Anderer
authors.forename: B
authors.initials: B
authors.lastname: Saletu
authors.forename: B
authors.initials: B
authors.lastname: Klöppel
authors.forename: H V
authors.initials: HV
authors.lastname: Semlitsch
authors.forename: H
authors.initials: H
authors.lastname: Werner
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000503:physiopathology*; D001931:Brain Mapping; D003704:Dementia / Q000503:physiopathology*; D016002:Discriminant Analysis; D004569:Electroencephalography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016571:Neural Networks, Computer; D012372:ROC Curve; D012680:Sensitivity and Specificity