[The quality of the preservation of lungs using different solutions (an experimental study)].
Effects of different perfusion conditions and storage of isolated dog lungs on the process of edema development were studied. Sixty-nine mongrel dogs were used in the study. In case of a 15 min perfusion via the pulmonary artery and 12 h storage lung condition depended mainly on the type of solution and addition of protective drugs to this solution. Euro-Collins and low-potassium electrolytic solution markedly increased capillary hydrostatic pressure and drastically reduced plasma colloid-osmotic pressure. As a result filtration coefficient increased and as soon as an hour after reperfusion onset a marked pulmonary edema developed. Use of LPD solution without drugs added for 2.5 h reperfusion was associated with a moderate increase of capillary hydrostatic pressure and negligible decrease of plasma colloid-osmotic pressure. If the reperfusion were longer plasma colloid-osmotic pressure reduced, this leading to development of moderate pulmonary edema. A 15 min lung perfusion via the pulmonary artery and 12 h storage at 1 degree C in LPD solution with membrane protectors and antioxidants was associated with virtually unchanged capillary hydrostatic pressure, plasma colloid-osmotic pressure, and filtration coefficient and, hence, no pulmonary edema.
Khodzhimatov
G M
GM
Movsesov
R V
RV
Zhavoronkov
N A
NA
Ivanova
A G
AG
Zhidkov
I L
IL
Sheremet'eva
G F
GF
Dement'eva
I I
II
Perel'man
M I
MI
D000818:Animals; D000975:Antioxidants; D003911:Dextrans; D004285:Dogs; D005069:Evaluation Studies as Topic; D005260:Female; D005947:Glucose; D006982:Hypertonic Solutions; D008168:Lung / Q000473:pathology / Q000502:physiology*; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion / Q000295:instrumentation / Q000379:methods; D011654:Pulmonary Edema / Q000209:etiology / Q000473:pathology; D015427:Reperfusion Injury / Q000209:etiology / Q000473:pathology; D013997:Time Factors
D000975:Antioxidants; D003911:Dextrans; C037096:Euro-Collins' solution; D006982:Hypertonic Solutions; C083290:low potassium dextran glucose solution; D005947:Glucose