Immunogenetic aspects of IgE-mediated responses.
The reported significant HLA association is consistent with the codominant expression of MHC-linked Ir genes. Similar studies are needed in the case of the other HLA-immune response associations. It seems unlikely that any unique HLA-D genetic sequence will be found only among subjects responding to a particular Ag. It is likely, however, that we will find that a particular sequence is a necessary, but not sufficient, requirement for responsiveness to a particular antigenic epitope. Previous family studies, in which failed to observed parent-to-child transmission of specific immune responsiveness to a particular allergen, suggest that further genetic and/or environmental factors are required for the expression of specific immune responsiveness. These factors include variations in the degree of antigenic exposure. Of particular importance is the need for Ag-specific TcR genes to be expressed in the mature T-cell repertoire. In study of the specific immune response, there have been several studies of the protein and DNA sequences of allergenic proteins; therefore, in regard to understanding the genetics of specific immune responsiveness to allergens and its relationship to atopic diseases, rapid advances can be anticipated over the next several years.
Huang
S K
SK
Johns Hopkins University School of Medicine, Johns Hopkins Asthma and Allergy Center, Baltimore, MD 21224.
Yi
M
M
Kumai
M
M
Marsh
D G
DG
D000485:Allergens / Q000276:immunology*; D000938:Antigen-Presenting Cells / Q000276:immunology; D052179:Antigens, Plant; D000939:Epitopes / Q000276:immunology; D005799:Genes, Dominant; D005803:Genes, Immunoglobulin; D005802:Genes, MHC Class II; D006684:HLA-DR Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics* / Q000276:immunology; D007073:Immunoglobulin E / Q000276:immunology*; D008213:Lymphocyte Activation; D010940:Plant Proteins / Q000276:immunology*; D011058:Pollen / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D006255:Rhinitis, Allergic, Seasonal / Q000235:genetics / Q000276:immunology
D000485:Allergens; D052179:Antigens, Plant; D000939:Epitopes; D006684:HLA-DR Antigens; D010940:Plant Proteins; D011948:Receptors, Antigen, T-Cell; C069543:group 5 allergens, Ambrosia; D007073:Immunoglobulin E