title: Linkage relationships between keratin-associated protein (KRTAP) genes and growth hormone in sheep.
abstract: The ovine hair keratin-associated protein (KRTAP) genes are grouped into several families. In this study, we analyzed linkage relationships between members of four KRTAP families and growth hormone and beta-hemoglobin. Restriction fragment length polymorphisms and a microsatellite polymorphism were typed in 10 sire groups from a flock of Australian Merino sheep. Two linkages, both previously undetected in sheep or any other mammal, were found. They were between growth hormone (GH) and the high-sulfur keratin gene family KRTAP1 (previously called high-sulfur B2C) at theta = 0.10, Z = 3.01 and between two high-glycine-tyrosine class genes, KRTAP6 (previously high-glycine-tyrosine type II) and KRTAP8 (previously high-glycine-tyrosine type I-F), at theta = 0.15, Z = 5.0. The high level of conservation of the mammalian genome at these recombination values suggests that these linkages might be found in distantly related mammalian species.
authors.affiliation: School of Biological Sciences, Macquarie University, New South Wales, Australia.
authors.forename: Y M
authors.initials: YM
authors.lastname: Parsons
authors.forename: L R
authors.initials: LR
authors.lastname: Piper
authors.forename: D W
authors.initials: DW
authors.lastname: Cooper
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D008040:Genetic Linkage; D013006:Growth Hormone / Q000235:genetics*; D006197:Hair / Q000378:metabolism; D007633:Keratins / Q000235:genetics*; D008126:Lod Score; D008322:Mammals / Q000235:genetics; D005810:Multigene Family; D012150:Polymorphism, Restriction Fragment Length; D011506:Proteins / Q000235:genetics*; D011995:Recombination, Genetic; D012756:Sheep / Q000235:genetics*
chemical_list: D011506:Proteins; D007633:Keratins; D013006:Growth Hormone