[Status of nucleic acid and total protein synthesis in hematopoietic organs in mice with alloxan diabetes].
Rates of 3H-thymidine, 3H-uridine and 14C-glycine incorporation in nucleic acids and total proteins were studied in cells of bone marrow, spleen, thymus and ileocecal lymph nodes tissues of BALB/c mice with subacute alloxan diabetes (content of blood sugar was higher than 14 mmol/l). Synthesis of DNA, RNA and protein was not considerably inhibited in the thymus tissue of the impaired animals which may correlate with pronounced dysfunction of cytotoxic T lymphocytes typical for the disease.
Kozlov
Iu A
IuA
Volkova
N P
NP
Baĭkov
A N
AN
Novitskiĭ
V V
VV
D000496:Alloxan; D000818:Animals; D001853:Bone Marrow / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis*; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D008198:Lymph Nodes / Q000378:metabolism; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis*; D013154:Spleen / Q000378:metabolism; D013950:Thymus Gland / Q000378:metabolism
D012313:RNA; D000496:Alloxan; D004247:DNA