Electrocorticographic evaluation of iobitridol, a nonionic contrast medium, during selective cerebral arteriography in rabbits.
OBJECTIVE
To study the effects of iobitridol, a nonionic contrast medium, on the electrocorticography and the blood-brain barrier structure in rabbits.


METHODS
Iobitridol was compared with isoosmolar mannitol and isotonic saline after selective injection (2.5 mL per rabbit in 30 seconds) into the internal carotid artery in the rabbit (six per group). The electrocorticograms (two frontooccipital leads) were then subjected to spectral analysis (fast Fourier transform). Evans blue dye served as a marker of blood-brain barrier damage.


RESULTS
No blood-brain barrier damage was found, regardless of the treatment administered. Selective catheterization induced an increase in slow waves (0 to 4 Hz). Analyzed both spectrally (distribution of frequency bands, position of the maximum peak with respect to the distribution, and cerebral electric power) and conventionally, iobitridol did not modify the electrocorticograph parameters in the animals. This also applied to the mannitol and saline solutions.


CONCLUSIONS
No chemotoxic effects of iobitridol were found.
Trocherie
S
S
Commissariat à l'Energie Atomique, Fontenay-aux-Roses, France.
Alaoui
F
F
Idée
J M
JM
Santus
R
R
Court
L
L
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects; D002533:Cerebral Angiography; D002540:Cerebral Cortex / Q000187:drug effects*; D003287:Contrast Media / Q000494:pharmacology*; D004569:Electroencephalography / Q000187:drug effects*; D005583:Fourier Analysis; D007472:Iohexol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D011817:Rabbits; D012815:Signal Processing, Computer-Assisted
D003287:Contrast Media; C093233:iobitridol; D007472:Iohexol