Immune response to human papillomavirus type 16 E6 gene in a live vaccinia vector.
Immunization of mice with a recombinant vaccinia virus expressing the human papillomavirus type 16 (HPV-16) E6 gene elicits specific antibody, proliferative and cytotoxic T lymphocyte responses. T and B cell epitopes were mapped by using synthetic peptides. This study provides the background to future investigation aimed at developing prophylactic and therapeutic vaccines against HPV-16 infection and cervical cancer.
Gao
L
L
Department of Biology, University College London, U.K.
Chain
B
B
Sinclair
C
C
Crawford
L
L
Zhou
J
J
Morris
J
J
Zhu
X
X
Stauss
H
H
D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000276:immunology; D001483:Base Sequence; D004268:DNA-Binding Proteins; D000939:Epitopes; D005260:Female; D005822:Genetic Vectors; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000096:biosynthesis / Q000235:genetics / Q000276:immunology*; D027383:Papillomaviridae / Q000235:genetics / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014614:Vaccines, Synthetic / Q000096:biosynthesis / Q000276:immunology*; D014616:Vaccinia virus / Q000235:genetics*
D000914:Antibodies, Viral; D004268:DNA-Binding Proteins; C052603:E6 protein, Human papillomavirus type 18; D000939:Epitopes; D009856:Oncogene Proteins, Viral; D014614:Vaccines, Synthetic