title: In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.
abstract: Genotoxicity evaluation of a widely used glucocorticoid medicine, dexamethasone, was undertaken using in vitro and in vivo assays. Analyses of chromosomal aberrations, sister-chromatid exchanges (SCEs) in human lymphocytes and micronuclei and SCEs in mouse bone marrow showed the drug to be capable of attacking the genetic material. However, the Ames/Salmonella assay, both with and without S9 mix, did not show any increase in His+ revertants.
authors.affiliation: Department of Human Genetics, Guru Nanak Dev University, Amritsar, India.
authors.forename: H
authors.initials: H
authors.lastname: Singh
authors.forename: J R
authors.initials: JR
authors.lastname: Singh
authors.forename: V S
authors.initials: VS
authors.lastname: Dhillon
authors.forename: D
authors.initials: D
authors.lastname: Bali
authors.forename: H
authors.initials: H
authors.lastname: Paul
mesh_terms: D000818:Animals; D001711:Biotransformation; D002869:Chromosome Aberrations; D003907:Dexamethasone / Q000633:toxicity*; D006801:Humans; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens; D012485:Salmonella typhi / Q000187:drug effects; D012854:Sister Chromatid Exchange
chemical_list: D009153:Mutagens; D003907:Dexamethasone