Dopamine-dependent diastolic dysfunction in moderate hypothermia.
We designed an experimental animal study to study the effects of dopamine (DA) on diastolic function in hypothermia. DA was applied at five incremental infusion rates in 6 sheep during normothermia and moderate hypothermia (29 degrees C). Left ventricular end-diastolic pressure (LVEDP) was increased during hypothermia as compared with normothermia at all doses of DA. Contraction and relaxation velocity were changed only slightly during hypothermia; during normothermia, both velocities were markedly increased. The pronounced hemodynamic effect observed during hypothermia was further intensified by occurrence of aftercontractions, which disappeared at very high DA doses. These paradoxic results were considered the result of hypothermia-induced reduction in active transport mechanisms responsible for regulation of the cytoplasmic CA2+ concentration. The generally reduced inotropic effect of DA, the risk of paradoxic reactions, and the occurrence of aftercontractions must be taken into account when emergency drugs are administered clinically during hypothermia.
Schröder
T
T
Abteilung Anaesthesiologische Forschung, Universität Göttingen, Germany.
Hering
J P
JP
Heidelmeyer
C F
CF
Pahl
R
R
Sipinková
I
I
Hellige
G
G
D000818:Animals; D003971:Diastole / Q000187:drug effects*; D004195:Disease Models, Animal; D004298:Dopamine / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006439:Hemodynamics / Q000187:drug effects*; D007035:Hypothermia / Q000503:physiopathology*; D009200:Myocardial Contraction / Q000187:drug effects; D012756:Sheep; D016277:Ventricular Function, Left / Q000187:drug effects
D004298:Dopamine