Clinical and immunological analysis of annular erythema associated with Sjögren syndrome.
Clinical and immunopathological analysis was performed on 24 cases of Sjögren syndrome with annular erythema (AESjS). AESjS predominantly appears on the cheek of the face where skin temperature is relatively low in comparison with other sites. VCAM-1 and ICAM-1 were strongly expressed on endothelial cells of AESjS, while epidermal expression of ICAM-1 was focal and weak. VCAM-1 mRNA expression was also much more intense compared to systemic lupus erythematosus. The lymphocyte response to staphylococcal enterotoxin B was higher in AESjS than that of controls, and cells positive for T cell receptor V beta 6,9,12 were expanded after the culture. Superantigen-driven endothelial-cell-dependent T cell infiltration to the skin plays a crucial role in AESjS.
Katayama
I
I
Department of Dermatology, Tokyo Medical and Dental University School of Medicine, Japan.
Yamamoto
T
T
Otoyama
K
K
Matsunaga
T
T
Nishioka
K
K
D000293:Adolescent; D000328:Adult; D000368:Aged; D015815:Cell Adhesion Molecules / Q000032:analysis; D002648:Child; D004730:Endothelium, Vascular / Q000737:chemistry; D004817:Epidermis / Q000737:chemistry; D004890:Erythema / Q000150:complications* / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D005148:Facial Dermatoses / Q000503:physiopathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D012859:Sjogren's Syndrome / Q000150:complications* / Q000276:immunology / Q000378:metabolism / Q000503:physiopathology; D012867:Skin / Q000098:blood supply; D012881:Skin Temperature; D019010:Vascular Cell Adhesion Molecule-1
D015815:Cell Adhesion Molecules; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1