Role of proteinase/antiproteinase inhibitor disequilibrium in the bioincompatibility induced by artificial surfaces.
As one aspect of bioincompatibility, the importance of activation of proteolytic systems as a result of an imbalance between protease and antiprotease activity has been increasingly recognized. This principle is illustrated by selected studies in our laboratory. These concern (i) generation of kinins on membranes with negative surface charge, (ii) activation of the complement system as a function of binding to the membrane of the regulatory protein H, (iii) generation of thrombin-antithrombin complexes (TAT), and (iv) generation of plasmin/antiplasmin complexes with an interesting discrepancy between in vivo and in vitro.
Deppisch
R
R
Gambro Research and Development, Hechingen, Germany.
Haug
U
U
Göhl
H
H
Ritz
E
E
D000818:Animals; D000933:Antifibrinolytic Agents; D000990:Antithrombin III / Q000737:chemistry*; D001672:Biocompatible Materials; D001777:Blood Coagulation; D003167:Complement Activation; D005112:Extracorporeal Circulation; D005341:Fibrinolysin / Q000037:antagonists & inhibitors* / Q000737:chemistry; D005342:Fibrinolysis; D006801:Humans; D007705:Kinins / Q000096:biosynthesis; D010447:Peptide Hydrolases / Q000737:chemistry*; D000979:alpha-2-Antiplasmin / Q000737:chemistry
D000933:Antifibrinolytic Agents; D001672:Biocompatible Materials; D007705:Kinins; D000979:alpha-2-Antiplasmin; C046193:antithrombin III-protease complex; C037742:plasmin-plasmin inhibitor complex; D000990:Antithrombin III; D010447:Peptide Hydrolases; D005341:Fibrinolysin