[Drug distribution and antitumor effect of bleomycin incorporated in poly DL-lactic acid in rats].
Two bleomycin (BLM)-containing agents (BLM-PLA, BLM-SOL) were prepared, and the drug distribution and antitumor effect were studied. BLM-PLA is an agent in which BLM is incorporated into biodegradable low-molecular-weight polylactic acid, and BLM-SOL is an aqueous solution of BLM. BLM-PLA or BLM-SOL was subcutaneously administered in the back of rats. When BLM-PLA was implanted, high BLM activity of the connective tissues near the implants was maintained for 2 weeks. On the other hand, BLM activity was very low when BLM-SOL was administered. The effects of BLM-PLA, BLM-SOL and nontreatment on tumor growth and survival time were compared using subcutaneous tumor of Yoshida sarcoma in 21 rats each. The survivors and mean survival time in BLM-PLA group, BLM-SOL group and nontreatment group was 14 and 44.6 days, 5 and 23.7 days, and 0 and 11.3 days, respectively. BLM-PLA was superior to BLM-SOL in both drug distribution and antitumor effect, and consequently BLM-PLA could be a useful tool in loco-regional chemotherapy.
Kumanohoso
T
T
First Dept. of Surgery, Kagoshima University School of Medicine.
Natsugoe
S
S
Tokuda
K
K
Shimada
M
M
Sagara
M
M
Shinkawa
T
T
Nakamura
K
K
Yamada
K
K
Fukuzaki
H
H
Aikou
T
T
D000818:Animals; D001761:Bleomycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D003692:Delayed-Action Preparations; D007773:Lactates / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011108:Polymers / Q000008:administration & dosage / Q000493:pharmacokinetics*; D051381:Rats; D012517:Sarcoma, Yoshida / Q000378:metabolism* / Q000473:pathology; D014018:Tissue Distribution
D003692:Delayed-Action Preparations; D007773:Lactates; D011108:Polymers; D001761:Bleomycin