Maternal serum markers. Estimation of the risk of Down's syndrome: a prospective study.
The risk of Down's syndrome pregnancies can be estimated by quantitation of maternal serum markers, namely alpha-fetoprotein, unconjugated estriol and human chorionic gonadotropin (triple test). A prospective study of 2892 pregnant women (median age 33.5 years) is reported. The detection rate of Down's syndrome pregnancies was 80% (confidence intervals 45%-100%) when a risk of 1:380 or greater was considered "screen positive", the false positive rate was 13.3% (confidence intervals 12.0%-14.5%). The importance of the accurate assessment of gestational age and the time of blood sampling are emphasized. Our findings are compared with similar studies performed in other laboratories.
Mancini
G
G
Ente Ospedaliero Sant'Anna, USL-IX, Turin, Italy.
Perona
M
M
Dall'Amico
D
D
Bollati
C
C
Albano
F
F
Mazzone
R
R
Rosso
M
M
Grosso
E
E
Migone
N
N
Fiocchi
F
F
D000328:Adult; D000649:Amniocentesis; D015415:Biomarkers / Q000097:blood; D006063:Chorionic Gonadotropin / Q000097:blood*; D015331:Cohort Studies; D004314:Down Syndrome / Q000175:diagnosis / Q000453:epidemiology*; D004964:Estriol / Q000097:blood*; D005189:False Positive Reactions; D005260:Female; D005865:Gestational Age; D006801:Humans; D007621:Karyotyping; D008403:Mass Screening; D008423:Maternal Age; D011247:Pregnancy / Q000097:blood*; D018566:Pregnancy, High-Risk; D011296:Prenatal Diagnosis; D011446:Prospective Studies; D012306:Risk; D000509:alpha-Fetoproteins / Q000032:analysis*
D015415:Biomarkers; D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D004964:Estriol