[The effect of absorbent materials with drugs on wound healing].
Absorptive hydrophilic materials (MAH) containing dioxydin and terrilytin as drug components were studied in experiments on guinea pigs infected with K-11 strain of E. coli. The results showed that the wounds in animals who did not receive treatment were cleaned by the 14th day, while the wounds in animals treated by applications of MAH with dioxydin and terrilytin became clean on the 3rd day, i. e. 5 times quicker. Absorptive hydrophilic materials containing dioxydin and teriilytin were easily handled, easily applied and removed, they did not injure the granulation tissue, and intensified growth of peripheral epithelialization. Thus, experimental study showed absorptive hydrophilic materials containing dioxydin and terrilytin to be highly effective in the treatment of purulent wounds, which allows them to be recommended for clinical use.
Buianov
V M
VM
Egiev
V N
VN
Akimova
A Ia
AIa
Gritskova
I V
IV
D000287:Administration, Topical; D000681:Amylases / Q000008:administration & dosage*; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage*; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D004195:Disease Models, Animal; D004337:Drug Carriers; D004338:Drug Combinations; D004927:Escherichia coli Infections / Q000628:therapy*; D005069:Evaluation Studies as Topic; D006168:Guinea Pigs; D010447:Peptide Hydrolases / Q000008:administration & dosage*; D011810:Quinoxalines / Q000008:administration & dosage*; D016060:Sorption Detoxification / Q000379:methods; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects; D014946:Wound Infection / Q000628:therapy*
D000890:Anti-Infective Agents; D000893:Anti-Inflammatory Agents; D004337:Drug Carriers; D004338:Drug Combinations; D011810:Quinoxalines; C001077:dioxidine; C009402:amylase, phosphates, proteases drug combinations; D000681:Amylases; D010447:Peptide Hydrolases