[In vivo effects of 24R,25-dihydroxyvitamin D3 on kidney alkaline phosphatase and gamma-glutamyltransferase of hypophysectomized rats].
The effects of 24R, 25-dihydroxyvitamin D3 (24, 25 (OH)2 D3) on alkaline phosphatase (ALP), gamma-glutamyltransferase (GGT) and acid phosphatase (ACP) activities were investigated on renal cortex of hypophysectomized (Hx) rats. ALP activity was increased by +27, +56 and +60% as compared to controls respectively 3, 6 and 12 h after intraperitoneal administration of the secosteroid (10 pmoles/100 g body weight). Stimulations of GGT activity began only after 6 h (+30%) and 12 h (+ 46%). ACP activity was not modified. In vivo, the two enzymatic inductions in kidneys of Hx rats were higher and longer than those obtained in vitro.
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Laboratoire de Physiologie, CHU-UFR des Sciences Médicales et Pharmaceutiques, Angers.
Girault
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Prelot
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D015650:24,25-Dihydroxyvitamin D 3 / Q000494:pharmacology*; D000469:Alkaline Phosphatase / Q000187:drug effects*; D000818:Animals; D007016:Hypophysectomy; D007668:Kidney / Q000187:drug effects* / Q000201:enzymology; D010902:Pituitary Gland / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D005723:gamma-Glutamyltransferase / Q000187:drug effects*
D015650:24,25-Dihydroxyvitamin D 3; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase