[Dopamine antibodies in parkinsonism patients and their possible role in the pathogenesis of the parkinsonian syndrome].
Dopamine antibodies (DAb) were found in the blood serum of parkinsonian patients, middle-aged and elderly, but not young. There was a correlation between the DAb incidence and dominant symptom in the middle-aged and elderly patients and between DAb and anginal parkinsonism in the elderly patients. DAb-binding serum gamma-globulins of parkinsonian patients injected into rat caudate nuclei induced the pathogenetic mechanism of Parkinson's syndrome (the generator of pathologically enhanced excitation-GPEE) in this brain part and evoked main parkinsonian symptoms (oligokinesia, rigidity and tremor). This effect was more expressed in the elderly rats compared with the young animals. The DAb role in the Parkinson's syndrome pathogenesis and in L-DOPA therapeutic tolerance formation is discussed.
Man'kovskiĭ
N B
NB
Karaban'
I N
IN
Kryzhanovskiĭ
G N
GN
Evseev
V A
VA
Magaeva
S V
SV
Vetrila
L A
LA
Trekova
N A
NA
Basharova
L A
LA
Golubev
K M
KM
D000328:Adult; D000368:Aged; D000375:Aging / Q000276:immunology; D000906:Antibodies / Q000008:administration & dosage / Q000097:blood / Q000633:toxicity*; D000918:Antibody Specificity; D002421:Caudate Nucleus; D004298:Dopamine / Q000276:immunology*; D004569:Electroencephalography; D006801:Humans; D007267:Injections; D008875:Middle Aged; D010300:Parkinson Disease / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D010302:Parkinson Disease, Secondary / Q000209:etiology* / Q000276:immunology / Q000503:physiopathology; D005719:gamma-Globulins / Q000008:administration & dosage / Q000032:analysis / Q000633:toxicity
D000906:Antibodies; D005719:gamma-Globulins; D004298:Dopamine