Adoptive transfer of experimental allergic neuritis in the immune suppressed host.
Experimental allergic neuritis (EAN) was induced in normal and irradiated Lewis rats by passively transferring T cells sensitized to SP-26, a peptide fragment of P2 myelin protein. The recipients became sick 4-8 days post transfer and the degree of disability correlated directly with the dose of T cells. Smaller doses caused demyelination of nerve roots and sciatic nerves and larger doses produced more severe demyelination and significant axonal degeneration. Irradiated recipients developed similar clinical EAN and showed macrophage-mediated demyelination despite severe suppression of the host inflammatory response.
Hahn
A F
AF
Department of Clinical Neurological Sciences, University of Western Ontario, London, Canada.
Feasby
T E
TE
Lovgren
D
D
Wilkie
L
L
D000818:Animals; D001369:Axons / Q000473:pathology / Q000648:ultrastructure; D004487:Edema / Q000473:pathology; D005260:Female; D007114:Immunization; D016219:Immunotherapy, Adoptive; D007249:Inflammation / Q000473:pathology; D004676:Myelin Basic Protein / Q000276:immunology*; D018996:Myelin P2 Protein; D009186:Myelin Sheath / Q000473:pathology; D009410:Nerve Degeneration; D009444:Neuritis, Autoimmune, Experimental / Q000276:immunology / Q000473:pathology*; D010446:Peptide Fragments / Q000276:immunology; D051381:Rats; D011917:Rats, Inbred Lew; D012584:Sciatic Nerve / Q000473:pathology*; D013126:Spinal Nerve Roots / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology* / Q000637:transplantation; D013997:Time Factors; D014916:Whole-Body Irradiation
D004676:Myelin Basic Protein; D018996:Myelin P2 Protein; D010446:Peptide Fragments