title: H reflex studies in neurolathyrism.
abstract: Sixteen patients with lathyrism, age ranging between 18 and 55 years and duration of illness between 2 and 25 years, underwent H reflex studies with the aim of studying motor neurone excitability. The patients had marked spasticity (Ashworth score ranging between 2 and 5) and mild to moderate leg weakness. Knee and ankle reflexes were exaggerated in all and the plantar response was extensor in 14 patients. The H reflex abnormalities included increased HM ratio indicating increased motoneurone excitability, significant lack of vibratory inhibition indicating altered transmission in the premotoneuronal portion of the H reflex pathway, and lack of reciprocal inhibition (P < 0.01). These H reflex abnormalities were not related to spasticity, weakness, clonus or plantar response. The H reflex recovery curve in 6 patients revealed increased excitability throughout the recovery curve. The secondary facilitation started and peaked slightly earlier than normal, and the late depression was not marked indicating change in excitability of motoneurones or of interneurones.
authors.affiliation: Department of Neurology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
authors.forename: U K
authors.initials: UK
authors.lastname: Misra
authors.forename: C M
authors.initials: CM
authors.lastname: Pandey
mesh_terms: D000293:Adolescent; D000328:Adult; D004576:Electromyography; D006181:H-Reflex / Q000502:physiology*; D006801:Humans; D007842:Lathyrism / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000209:etiology / Q000503:physiopathology*; D009132:Muscles / Q000503:physiopathology; D011930:Reaction Time / Q000502:physiology