Ig-secreting and interferon-gamma-producing cells in mice mucosally immunized with influenza virus.
1. Oral immunization of mice with influenza virus type A/Udorn, induced antigen-specific IgA antibodies in external secretions (e.g., saliva and fecal extract). 2. Increased numbers of antigen-specific IgA spot-forming cells (SFC) were seen in mononuclear cells isolated from IgA-effector tissues (e.g., SG) of mice orally-immunized with influenza virus. 3. Following oral or systemic immunization of mice, IFN gamma-secreting cells (Th1 type) displayed a characteristic pattern of distribution which was related to the route of immunization.
Novak
M
M
Secretech Inc., Birmingham, AL, USA.
Yamamoto
M
M
Fujihashi
K
K
Moldoveanu
Z
Z
Kiyono
H
H
McGhee
J R
JR
Mestecky
J
J
D000284:Administration, Oral; D000818:Animals; D000914:Antibodies, Viral / Q000096:biosynthesis / Q000097:blood; D000921:Antibody-Producing Cells / Q000276:immunology*; D000956:Antigens, Viral / Q000008:administration & dosage; D001402:B-Lymphocytes / Q000276:immunology; D018928:Immunity, Mucosal; D007114:Immunization; D007070:Immunoglobulin A / Q000097:blood; D007071:Immunoglobulin A, Secretory / Q000096:biosynthesis; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood; D009980:Influenza A virus / Q000276:immunology*; D007279:Injections, Subcutaneous; D007371:Interferon-gamma / Q000096:biosynthesis*; D051379:Mice; D008807:Mice, Inbred BALB C; D018417:Th1 Cells / Q000276:immunology
D000914:Antibodies, Viral; D000956:Antigens, Viral; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D007371:Interferon-gamma