title: Rectal adenocarcinoma with germ cell elements treated with chemotherapy.
abstract: A patient with adenocarcinoma of the rectum containing germ cell elements in the form of endodermal sinus tumor and choriocarcinoma is described, believed to be the first such tumor reported in the literature. The serum levels of alpha-fetoprotein and human chorionic gonadotropin were markedly elevated. The source of the markers was localized to the neoplastic tissue by the immunoperoxidase technique. The patient developed extensive hepatic metastases thought to be due to choriocarcinoma for which she received chemotherapy. One wk after commencing treatment a massive fatal hepatic hemorrhage occurred.
authors.affiliation: Department of Pathology, Royal Women's Hospital, Melbourne, Victoria.
authors.forename: A G
authors.initials: AG
authors.lastname: Ostör
authors.forename: W M
authors.initials: WM
authors.lastname: McNaughton
authors.forename: D W
authors.initials: DW
authors.lastname: Fortune
authors.forename: D
authors.initials: D
authors.lastname: Rischin
authors.forename: B L
authors.initials: BL
authors.lastname: Hillcoat
authors.forename: C B
authors.initials: CB
authors.lastname: Riley
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000473:pathology*; D000328:Adult; D002822:Choriocarcinoma / Q000097:blood / Q000473:pathology* / Q000556:secondary; D006063:Chorionic Gonadotropin / Q000097:blood; D018240:Endodermal Sinus Tumor / Q000097:blood / Q000473:pathology*; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000556:secondary*; D008727:Methotrexate / Q000627:therapeutic use; D009378:Neoplasms, Multiple Primary / Q000097:blood / Q000473:pathology*; D012004:Rectal Neoplasms / Q000097:blood / Q000473:pathology*; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D006063:Chorionic Gonadotropin; D000509:alpha-Fetoproteins; D008727:Methotrexate