Sugar-DNA molecular recognition: specific interaction of alpha-1,4-glucopyranose chains with DNA in the minor groove.
alpha(1,4) glucopyranose chains (dextrins) are shown to interact with DNA via hydrophobic interactions from the minor groove side, while alpha(1,6) dextrans do not bind DNA. The observed specific alpha(1,4) linked sugar-DNA interactions may have importance in recognition of DNA by ene-diyne class of antibiotics via their saccharide units which have mostly alpha(1,4) linkages.
Krishna
A G
AG
Division of Organic Chemistry, National Chemical Laboratory, Pune, India.
Balasubramanian
D
D
Ganesh
K N
KN
D001483:Base Sequence; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004247:DNA / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry; D003912:Dextrins / Q000737:chemistry*; D008320:Maltose / Q000737:chemistry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009429:Netropsin / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014312:Trisaccharides / Q000737:chemistry
D003911:Dextrans; D003912:Dextrins; D009838:Oligodeoxyribonucleotides; D014312:Trisaccharides; C008317:maltotriose; D009429:Netropsin; D008320:Maltose; D004247:DNA