Iodine induced splitting of peptide bonds in human thyroglobulin.
Human thyroglobulin pretreated with iodine (1mM) at alkaline pH is split to small molecular weight fragments after reduction with dithiothreitol. Iodine pretreatment alone did not induce any changes in the thyroglobulin molecular weight.
Gardas
A
A
Clinical Biochemistry Department Medical Centre of Postgraduate Education Warsaw, Poland.
Domek
H
H
D002851:Chromatography, High Pressure Liquid; D004226:Dithioerythritol / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007455:Iodine / Q000494:pharmacology*; D008970:Molecular Weight; D010455:Peptides / Q000032:analysis / Q000378:metabolism*; D013954:Thyroglobulin / Q000032:analysis / Q000378:metabolism*
D010455:Peptides; D004226:Dithioerythritol; D013954:Thyroglobulin; D007455:Iodine