title: KP-1: not a specific marker. Staining of 137 sarcomas, 48 lymphomas, 28 carcinomas, 7 malignant melanomas and 8 cystosarcoma phyllodes.
abstract: This study documents the reactions of the monoclonal antibody KP-1, which detects histiocytes in paraffin sections, with 137 sarcomas, 48 lymphomas, 28 carcinomas, 7 malignant melanomas and 8 cystosarcoma phyllodes. The soft tissue sarcomas had been previously immunophenotyped. Positive staining was obtained in all categories of sarcoma except clear-cell sarcomas. Most categories of sarcoma showed staining in less than 10% of tumour cells although a minority of leiomyosarcomas showed more extensive staining. Five of 7 malignant melanomas were also positive while all lymphomas and carcinomas were negative. We conclude that KP-1 positivity is not helpful in supporting the histiocytic origin of a tumour and is of limited value in the differential diagnosis of soft tissue sarcomas or their separation from other categories of malignancy.
authors.affiliation: Department of Pathology, Royal College of Surgeons in Ireland, Dublin.
authors.forename: M
authors.initials: M
authors.lastname: Cassidy
authors.forename: B
authors.initials: B
authors.lastname: Loftus
authors.forename: A
authors.initials: A
authors.lastname: Whelan
authors.forename: B
authors.initials: B
authors.lastname: Sabt
authors.forename: D
authors.initials: D
authors.lastname: Hickey
authors.forename: K
authors.initials: K
authors.lastname: Henry
authors.forename: M
authors.initials: M
authors.lastname: Leader
mesh_terms: D015703:Antigens, CD / Q000032:analysis*; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D001943:Breast Neoplasms / Q000737:chemistry*; D002277:Carcinoma / Q000737:chemistry*; D005260:Female; D006801:Humans; D008223:Lymphoma / Q000737:chemistry*; D008545:Melanoma / Q000737:chemistry*; D003557:Phyllodes Tumor / Q000737:chemistry*; D012509:Sarcoma / Q000737:chemistry*; D012983:Soft Tissue Neoplasms / Q000737:chemistry*; D013194:Staining and Labeling; D000097382:CD68 Molecule
chemical_list: D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D014408:Biomarkers, Tumor; C067980:CD68 antigen, human; D000097382:CD68 Molecule