Localized, late-onset, high-grade lymphoma following bone marrow transplantation: response to combination chemotherapy.
Non-Hodgkin's lymphoma is the commonest secondary cancer following bone marrow transplantation (BMT). We report the case of a 42-year-old man who developed a laryngeal high-grade B-cell lymphoma 5 years following a matched T depleted BMT for CML. Polymerase chain reaction (PCR) analysis using the microsatellite marker Cyp 19 demonstrated the donor origin of involved tissue. Epstein-Barr virus (EBV) genomic sequences were identified by PCR. Although EBV related B-cell lymphoproliferative disorders (BLPD) post BMT are difficult to treat, there was a complete remission in this patient following three courses of chemotherapy (CHOP) administered with G-CSF. This case of late-onset BLPD appears clinically distinct from the well-defined, aggressive, early post-transplant BLPD.
O'Riordan
J M
JM
Department of Haematology, St James's Hospital, Dublin, Ireland.
Molloy
K
K
O'Briain
D S
DS
Corbally
N
N
Devaney
D
D
McShane
D
D
Considine
N
N
McCann
S R
SR
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006566:Herpesviridae Infections / Q000150:complications*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy; D008228:Lymphoma, Non-Hodgkin / Q000000981:diagnostic imaging / Q000382:microbiology* / Q000628:therapy; D008297:Male; D009333:Neck / Q000000981:diagnostic imaging; D016609:Neoplasms, Second Primary / Q000382:microbiology; D016133:Polymerase Chain Reaction; D011241:Prednisone / Q000008:administration & dosage; D014057:Tomography, X-Ray Computed; D014412:Tumor Virus Infections / Q000150:complications*; D014750:Vincristine / Q000008:administration & dosage
D016179:Granulocyte Colony-Stimulating Factor; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone