[Calcium antagonists and primary prevention of coronary disease].
APSIS (Angina Prognosis Study in Stockholm) compared the effects of verapamil 480 mg/day and metoprolol 200 mg/day on the prognosis of 809 patients with stable angina over an average period of three and a half years. No difference was observed between the two treatment groups in terms of mortality, number of cardiovascular events or in term of quality of life. Verapamil seemed to be as effective and as well tolerated as the betablocker for long term therapy of stable angina. Moreover, an ancillary study suggests that it has a platelet anti-aggregant effect.
Rehnqvist
N
N
Karolinska Institutet, Danderyds Sjulhus, Suède.
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy*; D003327:Coronary Disease / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000009:adverse effects / Q000627:therapeutic use*; D008875:Middle Aged; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D014700:Verapamil / Q000009:adverse effects / Q000627:therapeutic use*
D014700:Verapamil; D008790:Metoprolol