title: Pathologic changes related to subcutaneous implantation of chlormadinone acetate for preventing estrus in bitches.
abstract: Pathologic changes related to chlormadinone acetate (CAP) implantation were examined using 14 bitches given doses 2.5 to 25 mg/kg for 2 years. Absence of corpus luteum in bitches given 5 mg/kg or more supported long-term preventive effect of CAP on estrus. The uteri were dose-dependently enlarged and mucometra was occasionally found. Endometrial epithelium hyperplasia was observed but less in smaller doses. Changes in the mammary gland were only growth and lactation at normal degree. No remarkable changes were observed in ACTH and LH cells in the pituitary gland. Low, stable levels of CAP maintained in plasma by subcutaneous implantation seemed to be the main reason for absence or slight CAP-related pathologic changes.
authors.affiliation: Pet Raisers' Guidance Center, Shizuoka Prefecture, Hamamatsu, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sahara
authors.forename: M
authors.initials: M
authors.lastname: Murakoshi
authors.forename: T
authors.initials: T
authors.lastname: Nishina
authors.forename: H
authors.initials: H
authors.lastname: Kino
authors.forename: T
authors.initials: T
authors.lastname: Tsutsui
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000818:Animals; D002715:Chlormadinone Acetate / Q000008:administration & dosage / Q000494:pharmacology / Q000633:toxicity*; D003338:Corpus Luteum / Q000187:drug effects / Q000473:pathology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D004343:Drug Implants; D004717:Endometrium / Q000187:drug effects / Q000473:pathology*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology; D004971:Estrus / Q000187:drug effects*; D005260:Female; D006965:Hyperplasia; D007774:Lactation / Q000187:drug effects; D007986:Luteinizing Hormone / Q000378:metabolism; D008321:Mammary Glands, Animal / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D010053:Ovary / Q000187:drug effects / Q000473:pathology*; D010902:Pituitary Gland / Q000187:drug effects / Q000378:metabolism; D014599:Uterus / Q000187:drug effects / Q000473:pathology*
chemical_list: D004343:Drug Implants; D002715:Chlormadinone Acetate; D000324:Adrenocorticotropic Hormone; D007986:Luteinizing Hormone