A high frequency of induction of chromosome aberrations in the bone marrow cells of LEC strain rats by X-irradiation.
LEC strain rats, which have been known to develop hereditarily spontaneous fulminant hepatitis 4 to 5 months after birth, are highly sensitive to whole-body X-irradiation when compared to WKAH strain rats. The present results showed that the frequencies of all types of chromosome aberrations induced by X-irradiation in the bone marrow cells of LEC rats were approximately 2- to 3-fold higher than those of WKAH rats, though no significant difference was observed in the frequency of spontaneous chromosome aberrations between LEC and WKAH rats.
Okui
T
T
Hokkaido Institute of Public Health, Sapporo, Japan.
Hayashi
M
M
Endoh
D
D
Sato
F
F
Kasai
N
N
Watanabe
T
T
Namioka
S
S
D000818:Animals; D001853:Bone Marrow / Q000528:radiation effects*; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D011836:Radiation Tolerance / Q000235:genetics*; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar; D014916:Whole-Body Irradiation