The integrin alpha 4 beta 1 and its counter receptor VCAM-1 in development and immune function.
The integrin alpha 4 beta 1 and its counter receptor vascular cell adhesion molecule-1 (VCAM-1) mediate well-described cell-cell interactions that are critical for immune function. However, these receptors also mediate cell-cell interactions that are important for skeletal muscle differentiation. We have found that contrasting transcriptional mechanisms control their patterns of expression in the immune system and in muscle. Recent studies indicate that alpha 4 beta 1 and VCAM-1 are also expressed in a number of developing tissues, implying that these receptors have a general role in facilitating cell-cell interactions during development.
Dean
D C
DC
Washington University School of Medicine, St. Louis, MO 63110.
Iademarco
M F
MF
Rosen
G D
GD
Sheppard
A M
AM
D000818:Animals; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000502:physiology*; D002450:Cell Communication / Q000276:immunology / Q000502:physiology; D002454:Cell Differentiation / Q000502:physiology; D004727:Endothelium / Q000276:immunology / Q000502:physiology; D006801:Humans; D039041:Integrin alpha4beta1; D016023:Integrins / Q000276:immunology / Q000502:physiology*; D024510:Muscle Development; D016029:Receptors, Very Late Antigen / Q000276:immunology / Q000502:physiology*; D019010:Vascular Cell Adhesion Molecule-1
D015815:Cell Adhesion Molecules; D039041:Integrin alpha4beta1; D016023:Integrins; D016029:Receptors, Very Late Antigen; D019010:Vascular Cell Adhesion Molecule-1