Patterns of blood pressure variability in normotensive and hypertensive rats.
We sought patterns in mean arterial pressure of normotensive rats and alterations in chronic hypertension. Pressure was recorded for 4-6 days by telemetry from conscious, unrestrained rats and sampled digitally at 3 Hz, using normotensive Sprague-Dawley rats, spontaneously hypertensive rats (SHR), and Sprague-Dawley rats with two-kidney, one-clip renovascular hypertension (2K,1C). Time series analysis was by fast Fourier transform. Power spectra were divided into ultradian (frequencies > 1/day), circadian (frequency = 1/day), and infradian (frequencies < 1/day) domains. In the ultradian band from approximately 0.1 to 10 mHz the spectra were 1/f and without distinct peaks. The slopes were not significantly different among the groups and ranged from -1.03 to -1.61. At frequencies > 10 mHz, power continued to decrease but with a lower slope. A peak centered at approximately 100 mHz was present in both normotensive and 2K,1C rats but not in SHR. SHR had significantly more ultradian power than the others. The circadian rhythm modulated power in the ultradian band. Modulation was most prominent in normotensives, in which the ultradian activity was highest during the night when rats are active and lowest during the day; less pronounced in 2K,1C; and not detectable in SHR. There are regular patterns of blood pressure fluctuations and specific modifications to the patterns by different forms of hypertension.
Holstein-Rathlou
N H
NH
Department of Physiology and Biophysics, Brown University, Providence, Rhode Island 02912, USA.
He
J
J
Wagner
A J
AJ
Marsh
D J
DJ
D000204:Activity Cycles; D000818:Animals; D001794:Blood Pressure; D002940:Circadian Rhythm; D005583:Fourier Analysis; D006973:Hypertension / Q000503:physiopathology*; D006978:Hypertension, Renovascular / Q000503:physiopathology; D051381:Rats; D011918:Rats, Inbred SHR; D017207:Rats, Sprague-Dawley; D012016:Reference Values; D013686:Telemetry