[The effect of a lipoxygenase inhibitor on the modulation of cholinoreceptor plasticity by 15-HETE].
The role of acyclic eicosanoids in the modulation of the plasticity of somatic cholinoreceptors, due to 15(S)-hydroxy-(5Z,8Z,11Z,13E)-eicosatetraenoic acid (15-HETE), was studied in identified neurons of Helix lucorum. Lipoxygenase inhibitor, nordihydroguaiaretic acid blocks the effects of 15-HETE on the extinction of the inward current, evoked by the rhythmic application of acetylcholine on the neuron. The conclusion was reached that the short-latency effect of 15-HETE, on the plasticity of cholinoreceptors is due to the inhibition it produces on the 5-lipoxygenase. This effect leads to a lowering on the level of acyclic eicosanoids which are formed by the action of this enzyme. The potentiation of the effect of the acyclic eicosanoids, whose synthesis is renewed in the second phase, is a plausible explanation of the long-latency modulatory effect of 15-HETE.
Pivovarov
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Egido-Villareal
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D000109:Acetylcholine / Q000494:pharmacology; D000818:Animals; D004347:Drug Interactions; D006372:Helix, Snails; D006893:Hydroxyeicosatetraenoic Acids / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D066298:In Vitro Techniques; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology; D009637:Masoprocol / Q000494:pharmacology*; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008839:Microelectrodes; D009473:Neuronal Plasticity / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011950:Receptors, Cholinergic / Q000187:drug effects* / Q000502:physiology; D013997:Time Factors
D006893:Hydroxyeicosatetraenoic Acids; D007473:Ion Channels; D011950:Receptors, Cholinergic; C025984:15-hydroxy-5,8,11,13-eicosatetraenoic acid; D009637:Masoprocol; D000109:Acetylcholine