Galanin antagonists block galanin-induced feeding in the hypothalamus and amygdala of the rat.
Galanin significantly increased food intake when microinjected into the region of the central nucleus of the amygdala as well as into the paraventricular nucleus of the hypothalamus. In the amygdala this effect was specific to feeding; no change in grooming, resting, or other behaviour was observed after galanin treatment. These results provide evidence that the amygdala may be an important site in the mediation of galanin-induced feeding. The galanin receptor antagonists, C7 and M40, antagonized galanin-induced feeding, while having no effect alone on food consumption in free-feeding rats. These new galanin receptor antagonists provide useful tools for further investigating the role of endogenous galanin in the regulation of feeding.
Corwin
R L
RL
Section on Behavioral Neuropharmacology, National Institute of Mental Health, Bethesda, MD 20892.
Robinson
J K
JK
Crawley
J N
JN
D000595:Amino Acid Sequence; D000679:Amygdala / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D005247:Feeding Behavior / Q000187:drug effects*; D019004:Galanin; D006120:Grooming / Q000187:drug effects; D008297:Male; D008845:Microinjections; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D010286:Paraventricular Hypothalamic Nucleus / Q000187:drug effects / Q000502:physiology*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000494:pharmacology*; D010455:Peptides / Q000008:administration & dosage / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013373:Substance P / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology
C079517:M40; D009479:Neuropeptides; D010446:Peptide Fragments; D010455:Peptides; C079788:galanin (1-13)-spantide amide; D013373:Substance P; D019004:Galanin