Alterations in the concentration of serotonergic and dopaminergic substances in the cerebrospinal fluid of patients with Parkinson's disease, and their changes after L-dopa administration.
In untreated patients with Parkinson's disease (PD), the total (free and conjugated) serotonin (5-HT) and dopamine (DA) concentrations in the cerebrospinal fluid decreased significantly. While the 5-HT concentration displayed a non-significant trend of negative correlation with the DA concentration in controls, it had a significant positive correlation with the DA concentration in untreated PD patients. In L-dopa-treated patients, the DA concentration increased remarkably, whereas the 5-HT concentration decreased further compared with untreated patients. The tryptophan, 5-hydroxyindolacetic acid (5-HIAA), and 3-OH kynurenine concentrations had significant positive correlations with L-dopa doses. The 5-HT concentration had a significant positive correlation with scores of psychomatric testing in L-dopa-treated patients.
Tohgi
H
H
Department of Neurology, Iwate Medical University, Morioka, Japan.
Abe
T
T
Takahashi
S
S
Takahashi
J
J
Hamato
H
H
D000368:Aged; D004298:Dopamine / Q000134:cerebrospinal fluid* / Q000502:physiology; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D007737:Kynurenine / Q000031:analogs & derivatives / Q000134:cerebrospinal fluid; D007980:Levodopa / Q000627:therapeutic use*; D008875:Middle Aged; D010300:Parkinson Disease / Q000134:cerebrospinal fluid* / Q000188:drug therapy / Q000523:psychology; D011594:Psychometrics; D012701:Serotonin / Q000134:cerebrospinal fluid* / Q000502:physiology
C005045:3-hydroxykynurenine; D012701:Serotonin; D007737:Kynurenine; D007980:Levodopa; D006897:Hydroxyindoleacetic Acid; D004298:Dopamine