title: A new biological activity for the neuropeptide FMRFamide: experimental evidence for a secretagogue effect on amylase secretion in the scallop Pecten maximus.
abstract: FMRFamide immunoreactivity in the digestive tract of the bivalve mollusc Pecten maximus was investigated by immunocytochemistry. Positive FMRFamide-like immunoreactivity was detected in nerve fibres in close contact with exocrine alpha amylase secreting cells. Physiological studies on enzymatically dissociated cells of the stomach-digestive gland complex demonstrated the involvement of FMRFamide and analogues in the control of alpha amylase release from the cells. The FMRFamide-induced secretion was shown to be time- and dose-dependent. In contrast to most naturally occurring vertebrate secretagogues which are hormones, FMRFamide appears to work in our in vitro system as a paracrine factor.
authors.affiliation: Laboratoire de Biologie et Biotechnologies Marines, IBBA, IFREMER Unité de Recherches Marines 14, Université de Caen, France.
authors.forename: P
authors.initials: P
authors.lastname: Favrel
authors.forename: W
authors.initials: W
authors.lastname: Giard
authors.forename: N
authors.initials: N
authors.lastname: Benlimane
authors.forename: E
authors.initials: E
authors.lastname: Boucaud-Camou
authors.forename: M
authors.initials: M
authors.lastname: Henry
mesh_terms: D000595:Amino Acid Sequence; D000681:Amylases / Q000378:metabolism*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D019835:FMRFamide; D007150:Immunohistochemistry; D008969:Molecular Sequence Data; D008974:Mollusca / Q000378:metabolism*; D009479:Neuropeptides / Q000032:analysis / Q000494:pharmacology*
chemical_list: D009479:Neuropeptides; D019835:FMRFamide; D000681:Amylases