Sephadex-induced granulomatous alveolitis in rat: effects of antigen manipulation.
A granulomatous alveolitis, with multinuclear cell formation combined with an eosinophilic peribronchiolitis, was achieved in rats by intratracheal administration of sephadex beads (G-200, Pharmacia, Sweden). The pattern of inflammation and the degree of postgranulomatous fibrosis were substantially dampened when the particles were dispersed by ultrasonification. The animals were analyzed with bronchoalveolar lavage and tissue morphology.
Bjermer
L
L
Department of Lung Medicine, University Hospital, Umeå, Sweden.
Sandström
T
T
Särnstrand
B
B
Brattsand
R
R
D000818:Animals; D001992:Bronchoalveolar Lavage Fluid; D003911:Dextrans / Q000008:administration & dosage / Q000009:adverse effects*; D004803:Eosinophilic Granuloma / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D008168:Lung / Q000276:immunology*; D017563:Lung Diseases, Interstitial / Q000139:chemically induced* / Q000276:immunology / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D003911:Dextrans; C025614:sephadex