Salmeterol inhibits anaphylactic histamine release from guinea-pig isolated mast cells.
Salmeterol (1 nM-100 microM) showed an inhibitory action on anaphylactic histamine release from mast cells, isolated from pleural and peritoneal cavities of actively sensitized guinea-pigs and stimulated by incubation with allergen. The effect is concentration-dependent and is reduced by the beta-adrenoceptor antagonist propranolol (1 microM). This study supports the hypothesis of an anti-inflammatory property of salmeterol, which concerns cells involved in the early phases of asthma.
Gentilini
G
G
Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
Grazia di Bello
M
M
Raspanti
S
S
Bindi
D
D
Mugnai
S
S
Zilletti
L
L
D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D000707:Anaphylaxis / Q000188:drug therapy*; D000818:Animals; D005470:Fluorometry; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D010529:Peritoneal Cavity / Q000166:cytology; D010994:Pleura / Q000166:cytology; D011433:Propranolol / Q000494:pharmacology; D000068299:Salmeterol Xinafoate
D000318:Adrenergic beta-Agonists; D006633:Histamine Antagonists; D000068299:Salmeterol Xinafoate; D011433:Propranolol; D000420:Albuterol