title: Atrial flutter termination by overdrive transesophageal pacing and the facilitating effect of oral propafenone.
abstract: Transesophageal overdrive atrial pacing is effective and safe for atrial flutter termination. The influence of antiarrhythmic drug therapy on this procedure is controversial. In this study, we investigated whether oral propafenone may facilitate this procedure. Thirty patients with type I atrial flutter were randomized into 2 groups in which transesophageal pacing was attempted: group A, without treatment; and group B, after oral administration of propafenone 600 mg. Transesophageal pacing was effective in interrupting atrial flutter in 53% of patients (8 of 15) in group A and in 87% of patients (13 of 15) in group B. A significant lengthening of the flutter cycle was observed with respect to the baseline in patients given propafenone (261 +/- 23 vs 217 +/- 25, p < 0.01). Sinus rhythm resumed at a shorter paced cycle in group A patients (166 +/- 13 vs 187 +/- 14 ms, p < 0.01). The transesophageal threshold for stable atrial capture was significantly lower in group A (20.5 +/- 0.2 vs 23.3 +/- 1.2, p < 0.01). In no patient was the threshold for atrial capture higher than the pain threshold. We did not observe abrupt enhancement of atrioventricular conduction. We conclude that propafenone is effective and safe when used with transesophageal pacing in the termination of atrial flutter. The slowing effect of the drug on intraatrial conduction and the possible stabilizing effect on the reentry circuit appear to be outweighed by the positive effect of propafenone on the excitable gap of the circuit, facilitating its capture and accounting for the beneficial effect of the drug on arrhythmia termination.
authors.affiliation: Cardiology Department, Policlinico San Pietro, Ponte San Pietro, Bergamo, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Doni
authors.forename: P
authors.initials: P
authors.lastname: Della Bella
authors.forename: A
authors.initials: A
authors.lastname: Kheir
authors.forename: M
authors.initials: M
authors.lastname: Manfredi
authors.forename: C
authors.initials: C
authors.lastname: Piemonti
authors.forename: E
authors.initials: E
authors.lastname: Staffiere
authors.forename: A
authors.initials: A
authors.lastname: Rimondini
authors.forename: C
authors.initials: C
authors.lastname: Fiorentini
mesh_terms: D000284:Administration, Oral; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D001282:Atrial Flutter / Q000188:drug therapy / Q000628:therapy*; D002304:Cardiac Pacing, Artificial; D004562:Electrocardiography; D006329:Heart Conduction System / Q000187:drug effects; D006801:Humans; D011405:Propafenone / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies
chemical_list: D000889:Anti-Arrhythmia Agents; D011405:Propafenone