Induction of specific-locus and dominant lethal mutations in male mice by trophosphamide.
Trophosphamide induced dominant lethal and specific-locus mutations in spermatozoa and spermatids of mice. The induction pattern of specific-locus and dominant lethal mutations shows two maxima in the mating intervals 1-4 and 9-16 days post treatment. The nature of induced mutations is suggested to be intergenic.
Ehling
U H
UH
GSF-Forschungszentrum für Umwelt und Gesundheit, GmbH, Institut für Säugetiergenetik, Neuherberg, Oberschleissheim, Germany.
Neuhäuser-Klaus
A
A
D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity*; D003520:Cyclophosphamide / Q000031:analogs & derivatives* / Q000633:toxicity; D005260:Female; D005799:Genes, Dominant; D005804:Genes, Lethal; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D013087:Spermatids / Q000187:drug effects; D013094:Spermatozoa / Q000187:drug effects
D000970:Antineoplastic Agents; D009153:Mutagens; D003520:Cyclophosphamide; C003726:trofosfamide