title: Therapy other than reverse transcriptase inhibitors for HIV infection.
abstract: Antiretroviral drugs against HIV infection have been developed that inhibit various stages of the HIV replication cycle. Agents other than reverse transcriptase inhibitors are reviewed with particular attention to those under study in clinical trials, including inhibitors of the virus-encoded protease enzyme. In addition, innovative strategies using gene therapy are described. It is concluded that combinations of agents may be the best approach for minimizing toxicity and reducing or delaying the emergence of drug-resistant virus during therapy.
authors.affiliation: Infectious Disease Unit, Massachusetts General Hospital, Boston.
authors.forename: J C
authors.initials: JC
authors.lastname: Kaplan
authors.forename: M S
authors.initials: MS
authors.lastname: Hirsch
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000188:drug therapy / Q000628:therapy*; D000998:Antiviral Agents / Q000627:therapeutic use*; D015496:CD4-Positive T-Lymphocytes / Q000821:virology; D004279:DNA, Viral / Q000235:genetics / Q000378:metabolism; D015316:Genetic Therapy; D015497:HIV-1 / Q000187:drug effects / Q000235:genetics / Q000502:physiology; D006801:Humans; D018894:Reverse Transcriptase Inhibitors; D014779:Virus Replication
chemical_list: D000998:Antiviral Agents; D004279:DNA, Viral; D018894:Reverse Transcriptase Inhibitors