Neuropeptide Y and galanin are coexpressed in rat large type A sensory neurons after peripheral transection.
Neuropeptide Y (NPY)-like immunoreactivity (IR) was observed in 20-30% of ipsilateral dorsal root ganglion (DRG) neurons (L4-5) after unilateral transection of rat sciatic nerve. Most of these neurons contained 200 kDa subunit of neurofilaments and galanin. Immunohistochemical analysis combined with retrograde tracing method demonstrated that NPY-IR was detected in cutaneous and muscular sensory, but not in visceral sensory neurons. These findings suggest that NPY coexists with galanin in injured large type A cells, which may innervate the mechanoreceptors in the skin and muscle, such as corpuscles of Meissner and Pacini, or muscle spindles.
Kashiba
H
H
Department of Physiology, Kansai College of Acupuncture Medicine, Osaka. Japan.
Noguchi
K
K
Ueda
Y
Y
Senba
E
E
D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis; D048429:Cell Size / Q000502:physiology; D019004:Galanin; D005727:Ganglia, Spinal / Q000737:chemistry / Q000473:pathology; D007150:Immunohistochemistry; D008297:Male; D009475:Neurons, Afferent / Q000737:chemistry*; D009478:Neuropeptide Y / Q000032:analysis*; D009479:Neuropeptides / Q000032:analysis*; D010455:Peptides / Q000032:analysis*; D051381:Rats; D017208:Rats, Wistar; D012584:Sciatic Nerve / Q000293:injuries*
D009478:Neuropeptide Y; D009479:Neuropeptides; D010455:Peptides; D019004:Galanin; D015740:Calcitonin Gene-Related Peptide