title: Hormonal receptors, cell proliferation fraction (Ki-67) and c-erbB-2 amplification in breast cancer. Relationship between differentiation degree and axillary lymph node metastases.
abstract: In view of the limitations of conventional prognostic factors such as differentiation degree, metastatic lymph nodes, hormonal receptors and others, especially when early lesions are found, additional new markers have been studied, such as gene amplification and cell proliferation index, in order to choose the appropriate treatment. Primary breast carcinoma tumors from 97 patients were examined for differentiation degree, metastatic lymph nodes, hormonal receptors, c-erbB-2 amplification and cell proliferation index (Ki-67). A negative relationship with hormonal receptors and c-erbB-2 amplification, Ki-67 and differentiation degree was found, whereas the relationship between c-erbB-2, Ki-67 and differentiation degree was positive. No relationship was found between these factors and metastatic lymph nodes. The concurrence of high cell proliferation index, c-erbB-2 amplification and negative hormonal receptor presence would indicate a subpopulation with a high risk of recurrence. But a larger survival study is necessary to correlate these factors with clinical outcome.
authors.affiliation: Department of Pathology, Verge de la Cinta Hospital, Tortosa, Tarragona, Spain.
authors.forename: J J
authors.initials: JJ
authors.lastname: Sirvent
authors.forename: M
authors.initials: M
authors.lastname: Santafé
authors.forename: M T
authors.initials: MT
authors.lastname: Salvadó
authors.forename: T
authors.initials: T
authors.lastname: Alvaro
authors.forename: A
authors.initials: A
authors.lastname: Raventós
authors.forename: J
authors.initials: J
authors.lastname: Palacios
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001365:Axilla; D001943:Breast Neoplasms / Q000473:pathology*; D002277:Carcinoma / Q000473:pathology*; D002454:Cell Differentiation; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen; D008198:Lymph Nodes / Q000473:pathology; D008207:Lymphatic Metastasis; D008597:Menstrual Cycle; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D009687:Nuclear Proteins / Q000032:analysis*; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis* / Q000235:genetics; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis; D011987:Receptors, Steroid / Q000032:analysis*; D013194:Staining and Labeling / Q000379:methods
chemical_list: D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D011987:Receptors, Steroid