title: [Endocrine chemotherapy for prostatic cancer].
abstract: We carried out a randomized joint study on endocrine therapy and endocrine chemotherapy for prostatic cancer at our department and 17 affiliated institutions. Of 80 patients entered, 39 patients were treated with chlormadinone acetate alone (group A) and 41 patients were treated with chlormadinone acetate in combination with UFT (group B). After excluding 10 inappropriate patients, Stage C was observed in 14 patients in group A and 13 in group B, and stage D in 20 patients in group A and 23 in group B. Side effects were observed in 8.8% (3/34) in group A and 22.2% (8/30) in group B without a significant difference. The anti-tumor effects (response rate) and clinical effects with respect to each item did not significantly differ between the two groups. The non-recurrence rate and survival rate were significantly higher in group B than in group A. These findings suggest the usefulness of endocrine chemotherapy using UFT.
authors.affiliation: Department of Urology, Osaka City University Medical School.
authors.forename: T
authors.initials: T
authors.lastname: Maekawa
authors.forename: N
authors.initials: N
authors.lastname: Kashihara
authors.forename: M
authors.initials: M
authors.lastname: Tsujita
authors.forename: Y
authors.initials: Y
authors.lastname: Morikawa
authors.forename: N
authors.initials: N
authors.lastname: Hayahara
authors.forename: T
authors.initials: T
authors.lastname: Nishijima
authors.forename: K
authors.initials: K
authors.lastname: Ezaki
authors.forename: M
authors.initials: M
authors.lastname: Senju
authors.forename: M
authors.initials: M
authors.lastname: Iritani
authors.forename: M
authors.initials: M
authors.lastname: Yamaguchi
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002715:Chlormadinone Acetate / Q000008:administration & dosage; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000473:pathology; D015996:Survival Rate; D005641:Tegafur / Q000008:administration & dosage; D014498:Uracil / Q000008:administration & dosage
chemical_list: D002715:Chlormadinone Acetate; D005641:Tegafur; D014498:Uracil