SLe(x) expression of normal CD34 positive bone marrow haemopoietic progenitor cells.
We investigated sialylated Lewis x (sLe(x)) antigen expression on CD34 positive (CD34+) haemopoietic progenitors in the bone marrow of eight healthy volunteers using monoclonal antibodies. We found that in all the samples examined, CD34+ bone marrow progenitors strongly expressed the sLe(x) antigen. This contradicts previous publications which reported sLe(x) expression on malignant blast cells but not on normal CD34+ progenitor cells.
Karakantza
M
M
Department of Cellular and Molecular Sciences, St George's Hospital Medical School, London.
Gibson
F M
FM
Cavenagh
J D
JD
Ball
S E
SE
Gordon
M Y
MY
Gordon-Smith
E C
EC
D015703:Antigens, CD / Q000032:analysis*; D018952:Antigens, CD34; D001853:Bone Marrow / Q000276:immunology*; D005455:Fluorescent Antibody Technique; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D006801:Humans; D016256:Lewis X Antigen / Q000032:analysis*
D015703:Antigens, CD; D018952:Antigens, CD34; D016256:Lewis X Antigen