Acute effects of intravascular absorption of 32% dextran 70 on blood coagulation, electrolytes and arterial blood gas.
Thirty-two percent dextran 70 is used to help visualize the uterine cavity during hysteroscopy and is also used intraperitoneally to prevent adhesions. We measured serum electrolytes, serum osmolarity, hematocrit, arterial blood gas and coagulation profile in 11 patients receiving dextran 70 while undergoing hysteroscopy. Dextran 70 had no significant effect on prothrombin time, partial thromboplastin time, thrombin time, fibrinogen level or serum osmolarity. There was a significant decrease in hematocrit, serum sodium and oxygen tension of arterial blood (PaO2). The decrease in sodium and hematocrit suggested hemodilution. This study demonstrated that 32% dextran 70 had a minimal effect on the majority of laboratory parameters measured.
Mangar
D
D
Department of Anesthesiology, Tampa General Hospital, Florida 33601.
Herzbrun
L
L
Camporesi
E M
EM
D000042:Absorption; D001777:Blood Coagulation / Q000187:drug effects*; D001784:Blood Gas Analysis; D003911:Dextrans / Q000009:adverse effects / Q000493:pharmacokinetics*; D005260:Female; D006400:Hematocrit; D006438:Hemodilution; D006801:Humans; D015907:Hysteroscopy / Q000379:methods*; D009994:Osmolar Concentration; D010100:Oxygen / Q000097:blood*; D012964:Sodium / Q000097:blood*; D014592:Uterine Hemorrhage / Q000097:blood* / Q000175:diagnosis / Q000601:surgery*
D003911:Dextrans; D012964:Sodium; D010100:Oxygen