title: Statistics of RNA melting kinetics.
abstract: We present and study the behavior of a simple kinetic model for the melting of RNA secondary structures, given that those structures are known. The model is then used as a map that assigns structure dependent overall rate constants of melting (or refolding) to a sequence. This induces a "landscape" of reaction rates, or activation energies, over the space of sequences with fixed length. We study the distribution and the correlation structure of these activation energies.
authors.affiliation: Institut für Theoretische Chemie, Universität Wien, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Tacker
authors.forename: W
authors.initials: W
authors.lastname: Fontana
authors.forename: P F
authors.initials: PF
authors.lastname: Stadler
authors.forename: P
authors.initials: P
authors.lastname: Schuster
mesh_terms: D001483:Base Sequence; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004926:Escherichia coli / Q000737:chemistry; D007700:Kinetics; D008954:Models, Biological; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry*; D012329:RNA, Bacterial / Q000737:chemistry; D012360:RNA, Transfer, Phe / Q000737:chemistry; D013223:Statistics as Topic; D013696:Temperature
chemical_list: D012329:RNA, Bacterial; D012360:RNA, Transfer, Phe; D012313:RNA