title: [Virus-associated hemophagocytic syndrome due to rubella virus in an adult].
abstract: A 57-year-old woman was admitted to our hospital because of fever and eruption. On admission, her white blood cell count was 1,600/ml, and platelet count 1.7 x 10(4)/ml. Ferritin and lysozyme were elevated. Bone marrow aspiration showed 4% histiocyte with hemophagocytosis. The anti-rubella virus antibody titer was 1:64, and that at convalescence stage was 1:254. Therefore, she was diagnosed to have virus-associated hemophagocytic syndrome (VAHS). Steroid (methylprednisolone 1,000 mg x 3 days) and gamma globulin therapy were initiated. Her clinical condition and laboratory data were promptly improved. Thus, it was suggested that steroid-pulse and gamma globulin therapy are effective in the early stage of this syndrome in adult.
authors.affiliation: Department of Internal Medicine, Kishiwada City Hospital.
authors.forename: H
authors.initials: H
authors.lastname: Marusawa
authors.forename: K
authors.initials: K
authors.lastname: Hamamoto
mesh_terms: D004334:Drug Administration Schedule; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D008775:Methylprednisolone / Q000008:administration & dosage; D008875:Middle Aged; D012409:Rubella; D005719:gamma-Globulins / Q000008:administration & dosage
chemical_list: D005719:gamma-Globulins; D008775:Methylprednisolone