Polarographic reduction and carcinogenic index tg alpha of 5-aza nucleosides possessing antileukemic activity.
Polarographic behavior of arabinosyl-5-azacytosine (ara-AC) and 5-azacytidine in anhydrous dimethylformamide and in Britton Robinson buffer is described. 5-Azacytidine and ara-AC underwent two-electron reduction under the polarographic conditions used. Carcinogenic index tg alpha estimated in the presence of alpha-lipoic acid was 0.295 for 5-azacytidine and 0.275 for ara-AC.
Vachálková
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Department of Experimental Therapy, Slovak Academy of Sciences, Bratislava.
Novotný
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L
Pískala
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D000970:Antineoplastic Agents / Q000737:chemistry*; D001374:Azacitidine / Q000737:chemistry* / Q000633:toxicity* / Q000031:analogs & derivatives; D002273:Carcinogens / Q000737:chemistry / Q000633:toxicity*; D003561:Cytarabine / Q000737:chemistry; D003562:Cytidine / Q000737:chemistry; D015394:Molecular Structure; D010084:Oxidation-Reduction; D011048:Polarography; D013329:Structure-Activity Relationship
D000970:Antineoplastic Agents; D002273:Carcinogens; D003561:Cytarabine; D003562:Cytidine; C022121:fazarabine; D001374:Azacitidine