[Blood screening for Down's syndrome in women under 35 years of age with an age-independent index].
The need for alternatives to amniocentesis, beset by 1% abortion rate, has been increasingly voiced over the past years and also includes the under 35 age group. However, the known age-dependent screening programs such as Alpha program according to Wald (1988) and the Dermalog Program according to Norgaard-Pederson (1990) only yield a detection rate of 50 or, at best, 70% (Müller, 1992) for this age group. We tried to improve this result by index calculation. Compared to the tested age-dependent screening programs the Ulm Index achieves a 25 to 40% higher detection rate (85%). For pregnant women beyond 35 years the detection rate of Down's syndrome can even be raised to 95-100% by a combination of the Alpha or Dermalog program with the Ulm Index, without entailling an increase in the rate of false-positive results.
Benz
R
R
Gynäkologische Praxisklinik Ulm.
Müller
U
U
Krahner-Pilat
M
M
Wagner-Geuder
S
S
Terinde
R
R
D000328:Adult; D000649:Amniocentesis; D001499:Bayes Theorem; D006063:Chorionic Gonadotropin / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human; D004314:Down Syndrome / Q000097:blood / Q000235:genetics / Q000517:prevention & control*; D004964:Estriol / Q000097:blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008403:Mass Screening; D008423:Maternal Age; D010446:Peptide Fragments / Q000097:blood; D010641:Phenotype; D011237:Predictive Value of Tests; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D018566:Pregnancy, High-Risk; D011296:Prenatal Diagnosis; D012307:Risk Factors; D000509:alpha-Fetoproteins / Q000032:analysis
D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D000509:alpha-Fetoproteins; D004964:Estriol