Emergence of alpha 5 beta 1 fibronectin- and alpha v beta 3 vitronectin-receptor expression in melanocytic tumour progression.
Cell adhesion is crucial in the process of tumour progression. As integrins are important receptor molecules involved in cell adhesion, we studied the distribution of the alpha 1-6, alpha v, alpha IIb, beta 1, beta 3, and beta 4 integrin subunits in tissue sections of common naevocellular naevi (n = 22), dysplastic naevi (16), thin (24) and thick primary cutaneous melanomas (28), and melanoma metastases (25). We found correlated expression of alpha 1/alpha 2, of alpha 4/alpha 5/beta 3, and of alpha 6/beta 4. Decrease of alpha 6 and beta 4, and increase of alpha 4 and alpha v were found to be correlated with melanoma progression. Furthermore, expression of alpha 5 and beta 3 was detected only in primary melanoma and melanoma metastasis. Our findings indicate that during melanoma progression alterations in integrin expression occur, the most striking being emergence of alpha 5 beta 1 fibronectin and alpha v beta 3 vitonectin receptor.
Danen
E H
EH
Department of Pathology, University Hospital Nijmegen, The Netherlands.
Ten Berge
P J
PJ
Van Muijen
G N
GN
Van 't Hof-Grootenboer
A E
AE
Bröcker
E B
EB
Ruiter
D J
DJ
D001706:Biopsy; D006801:Humans; D007150:Immunohistochemistry; D016023:Integrins / Q000032:analysis* / Q000096:biosynthesis*; D008545:Melanoma / Q000737:chemistry* / Q000556:secondary; D009361:Neoplasm Invasiveness / Q000503:physiopathology; D009506:Nevus / Q000737:chemistry* / Q000473:pathology; D016024:Receptors, Cytoadhesin / Q000032:analysis / Q000096:biosynthesis; D017469:Receptors, Fibronectin; D019030:Receptors, Vitronectin; D012878:Skin Neoplasms / Q000737:chemistry* / Q000473:pathology
D016023:Integrins; D016024:Receptors, Cytoadhesin; D017469:Receptors, Fibronectin; D019030:Receptors, Vitronectin