[Anti-inflammatory effect of a traditional Chinese medicine, ren-shen-yang-rong-tang (Japanese name: ninjin-youei-to), on alveolar macrophages stimulated by RANTES or TNF-alpha].
This study was performed to clarify the effect of RANTES or TNF-alpha on rabbit alveolar macrophages and the anti-inflammatory effect of NINJIN-YOUEI-TO on alveolar macrophages stimulated by RANTES or TNF-alpha. Phagocytosis of alveolar macrophages was dose-dependently stimulated by RANTES or TNF-alpha. However, phagocytosis of alveolar macrophages was completely suppressed to the basal level when alveolar macrophages were preincubated with NINJIN-YOUEI-TO at 37 degrees C for 20 min. These results suggest that NINJIN-YOUEI-TO has an anti-inflammatory effect on alveolar macrophages through a process still to be determined.
Aoki
T
T
Department of Pediatrics, Kansai Medical University.
Kojima
T
T
Kameda
N
N
Yoshijima
S
S
Ono
A
A
Kobayashi
Y
Y
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D018946:Chemokine CCL5; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D008222:Lymphokines / Q000494:pharmacology*; D016676:Macrophages, Alveolar / Q000276:immunology*; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D018946:Chemokine CCL5; D004365:Drugs, Chinese Herbal; D008222:Lymphokines; D014409:Tumor Necrosis Factor-alpha; C072867:ren-shen-yang-rong-tang