Induction of heat shock protein and prevention of caerulein-induced pancreatitis by water-immersion stress in rats.
Water-immersion stress is known to be involved in the development of hemorrhagic pancreatitis in caerulein-induced pancreatitis, when the stress is given following caerulein injection. The effects of pre-treatment with water-immersion to caerulein-induced pancreatitis were investigated in this study. 1. A 60-kDa heat shock protein was induced by pre-treatment with water-immersion stress in the pancreas. 2. Intra-peritoneal injection of caerulein (40 micrograms/kg) induced acute pancreatitis in rats without pre-treatment with water-immersion. However, when the rats were pre-treated with water-immersion, acute pancreatitis was not developed and no change of serum amylase levels was observed by i.p. injection of caerulein.
Otaka
M
M
First Department of Internal Medicine, Akita University School of Medicine, Japan.
Itoh
H
H
Kuwabara
T
T
Zeniya
A
A
Fujimori
S
S
Otani
S
S
Tashima
Y
Y
Masamune
O
O
D000681:Amylases / Q000097:blood; D000704:Analysis of Variance; D000818:Animals; D002108:Ceruletide / Q000008:administration & dosage / Q000633:toxicity*; D006360:Heat-Shock Proteins / Q000096:biosynthesis*; D007274:Injections, Intraperitoneal; D008297:Male; D008970:Molecular Weight; D010179:Pancreas / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014867:Water / Q000494:pharmacology*
D006360:Heat-Shock Proteins; D014867:Water; D002108:Ceruletide; D000681:Amylases