title: Human osteoclast-like cells recognize laminin via an RGD independent mechanism.
abstract: Interactions between cells from human giant cell tumors of bone and the extracellular matrix protein laminin were studied. Cells were capable of recognizing this substratum via a RGD-independent mechanism. Recognition induces adhesion and spreading onto laminin. This protein triggered the release of cellular FN which in turn enhanced recruitment of the beta 1 chain-containing integrin receptor.
authors.affiliation: Istituto di Anatomia Umana Normale, Università di Bari.
authors.forename: S
authors.initials: S
authors.lastname: Colucci
authors.forename: M
authors.initials: M
authors.lastname: Grano
authors.forename: P
authors.initials: P
authors.lastname: Zigrino
authors.forename: G
authors.initials: G
authors.lastname: Santacroce
authors.forename: G
authors.initials: G
authors.lastname: Zambonin
authors.forename: A
authors.initials: A
authors.lastname: Teti
authors.forename: A
authors.initials: A
authors.lastname: Zambonin Zallone
mesh_terms: D000595:Amino Acid Sequence; D001859:Bone Neoplasms / Q000473:pathology; D002448:Cell Adhesion / Q000187:drug effects; D005353:Fibronectins / Q000378:metabolism; D018212:Giant Cell Tumor of Bone / Q000473:pathology; D006801:Humans; D019012:Integrin beta1; D016023:Integrins / Q000378:metabolism; D007797:Laminin / Q000378:metabolism*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000494:pharmacology*; D010010:Osteoclasts / Q000187:drug effects / Q000378:metabolism*; D017474:Receptors, Laminin / Q000378:metabolism; D014407:Tumor Cells, Cultured
chemical_list: D005353:Fibronectins; D019012:Integrin beta1; D016023:Integrins; D007797:Laminin; D009842:Oligopeptides; D017474:Receptors, Laminin; C047981:arginyl-glycyl-aspartic acid; C058161:glycyl-arginyl-glycyl-aspartyl-seryl-proline; C058347:glycyl-arginyl-glycyl-glutamyl-seryl-proline