Effect of fepradinol on rat hind paw oedema induced by several inflammatory agents.
Fepradinol is an effective non-steroidal anti-inflammatory agent. The effect on rat paw oedema induced by various phlogistic agents was investigated. The inhibitory effect of fepradinol (25 mg kg-1, p.o.) on dextran-induced oedema was nearly equal to that of cyproheptadine (10 mg kg-1, p.o.). On oedema induced by platelet-activating factor only fepradinol (25 mg kg-1, p.o.) and phenidone (100 mg kg-1, p.o.) clearly inhibited the inflammatory process. Both the above induced oedemas are thought to be unrelated to prostaglandins in the rat system and therefore, the anti-inflammatory activity against them is not shared by selective cyclo-oxygenase inhibitors. Fepradinol (25 mg kg-1, p.o.) displayed an inhibitory effect on the early and late stage of kaolin- and nystatin-induced oedemas in contrast with indomethacin (10 mg kg-1, p.o.) and piroxicam (10 mg kg-1, p.o.) which only inhibited the late stage. The results obtained in this study confirm that fepradinol is a potent anti-inflammatory agent and indicate that its mechanism of action is different from that of other anti-inflammatory compounds.
Masso
J M
JM
Department of Pharmacology, ELMU S.A., Madrid, Spain.
Conde
J R
JR
Villar
A M
AM
Martorell
J
J
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D003911:Dextrans; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D004983:Ethanolamines / Q000627:therapeutic use*; D005528:Foot / Q000473:pathology; D007616:Kaolin; D008297:Male; D009761:Nystatin; D010972:Platelet Activating Factor; D051381:Rats; D017208:Rats, Wistar
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003911:Dextrans; D004983:Ethanolamines; D010972:Platelet Activating Factor; D009761:Nystatin; D007616:Kaolin; C078462:fepradinol