title: Modulation of the growth of hematopoietic human stem cells by growth factors: comparison of umbilical cord blood with bone marrow.
abstract: The growth of cord blood and bone marrow myeloid mononuclear cells in response to single and multiple growth factors has been examined. Single factors such as IL-3, IL-6, GM-CSF, and stem cell factor did not optimally stimulate growth of cord blood CFU-GM. However a synergistic stimulation was observed when the factors were combined. This effect was seen in both the presence and absence of added fetal calf serum.
authors.affiliation: Service de Médecine Interne, Clinique Henri Tagnon, Institut J. Bordet, Brussels, Belgium.
authors.forename: C
authors.initials: C
authors.lastname: DeBruyn
authors.forename: P
authors.initials: P
authors.lastname: Stryckmans
authors.forename: D
authors.initials: D
authors.lastname: Bron
authors.forename: P
authors.initials: P
authors.lastname: Ley
authors.forename: M
authors.initials: M
authors.lastname: Degueldre
authors.forename: A
authors.initials: A
authors.lastname: Delforge
mesh_terms: D015703:Antigens, CD; D018952:Antigens, CD34; D002469:Cell Separation / Q000295:instrumentation / Q000379:methods*; D003973:Diatrizoate; D005312:Fetal Blood / Q000166:cytology*; D005362:Ficoll; D005780:Gelatin; D006412:Hematopoietic Stem Cells; D006801:Humans; D007231:Infant, Newborn; D008747:Methylcellulose; D011205:Povidone; D012822:Silicon Dioxide
chemical_list: D015703:Antigens, CD; D018952:Antigens, CD34; D003973:Diatrizoate; D005362:Ficoll; C016039:Percoll; D012822:Silicon Dioxide; D005780:Gelatin; D008747:Methylcellulose; D011205:Povidone