Discovery, mechanism and expected clinical significance of selective cytotoxicity of 2-chloro-2'-deoxyadenosine (2-CdA).
2-Chloro-2'-deoxyadenosine (2-CdA) is a new promising antileukemic and immusuppressive agent. Discovery of 2-CdA and its unique properties, methods of synthesis, data explaining mechanism of its selective cytotoxicity, and current clinical status of the drug are briefly reviewed.
Grieb
P
P
Department of Neurophysiology, Polish Academy of Sciences, Warsaw.
D000964:Antimetabolites, Antineoplastic / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D017338:Cladribine / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity; D006801:Humans; D007166:Immunosuppressive Agents / Q000138:chemical synthesis / Q000494:pharmacology* / Q000633:toxicity
D000964:Antimetabolites, Antineoplastic; D007166:Immunosuppressive Agents; D017338:Cladribine