Fluid shifts induced by the administration of 7.5% sodium chloride in 6% dextran 70 (HSD) in dehydrated swine.
This study determined the effects of HSD administration on fluid distribution, following dehydration in Female Yucatan micro pigs. Dehydration at 33 degrees C resulted in: significantly increased core temperature (37.2 +/- 0.2 (mean +/- SE) to 39.0 +/- 0.1 degrees C), and decreased (4.4 +/- 0.4%) body weight and plasma volume (PV, 43 +/- 2 to 37 +/- 1 ml/kg). HSD but not saline administration resulted in significant increases (over postdehydration levels) in PV (46 +/- 3 ml/kg), sodium concentration (141 +/- 1 to 150 +/- 2 mEq/L), and osmolality (291 +/- 2 to 307 +/- 11 mOsm). Following return of water to the animals, these values returned to baseline levels. Since insensible (respiratory and transdermal) water loss for the 24 hr at 23 degrees C was 714 +/- 64 ml, and for the 24 hr at 33 degrees C was 653 +/- 64 ml, increasing the ambient temperature did not result in increased dehydration in swine. HSD administration restored PV to baseline levels despite prior water loss dehydration.
Matthew
C B
CB
U.S. Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760-5007.
Durkot
M J
MJ
Patterson
D R
DR
D000818:Animals; D001794:Blood Pressure; D003681:Dehydration / Q000503:physiopathology / Q000628:therapy*; D003911:Dextrans / Q000627:therapeutic use*; D005260:Female; D010953:Plasma Volume; D012151:Resuscitation; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D013552:Swine
D003911:Dextrans; D012462:Saline Solution, Hypertonic