title: Diagnostic and management problems in childhood visceral leishmaniasis in south-western Saudi Arabia.
abstract: The diagnosis and management of childhood visceral leishmaniasis were studied in 51 parasitologically proven cases from Abha, Saudi Arabia. Bone marrow aspiration was positive in 40 of 47 cases (85%). Splenic aspiration, though rarely used because of perceived dangers, was not associated with complications and revealed the parasite in all 12 cases in which it was used. There was prompt response to sodium stibogluconate, with defervescence in 93% and decrease of hepatosplenomegaly in 67% of patients within 1 week of commencing chemotherapy. A dose of 20 mg/kg/day for at least 3 weeks was generally safe and effective in achieving cure and preventing relapse. Two children with persistent massive splenomegaly after the first course responded to prolonged chemotherapy. Bronchopneumonia and severe cytopenia were common complications. Disseminated intravascular coagulation and hepatitis were associated with a poor outcome. The four patients who died had a progressive course with multiple complications. Early detection and appropriate management of complications may help to reduce morbidity and mortality in childhood visceral leishmaniasis.
authors.affiliation: Department of Child Health, College of Medicine, King Saud University, Abha, Saudi Arabia.
authors.forename: B
authors.initials: B
authors.lastname: Benjamin
authors.forename: S H
authors.initials: SH
authors.lastname: Annobil
authors.forename: W A
authors.initials: WA
authors.lastname: Bassuni
mesh_terms: D000967:Antimony Sodium Gluconate / Q000008:administration & dosage / Q000627:therapeutic use*; D001856:Bone Marrow Examination; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007273:Injections, Intramuscular; D007898:Leishmaniasis, Visceral / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy / Q000628:therapy*; D008297:Male; D012189:Retrospective Studies; D012529:Saudi Arabia; D013154:Spleen / Q000473:pathology
chemical_list: D000967:Antimony Sodium Gluconate