Amylase-producing Bence Jones multiple myeloma with pancreatitis-like symptoms.
Amylase-producing tumors are mainly adenocarcinomas and, in rare instances, multiple myelomas. We describe here a first case of amylase-producing Bence Jones type myeloma with pancreatitis-like symptoms and the second in a Caucasian patient. The finding of salivary-type hyperamylasemia in a 72-year-old female with a possible pancreatitis made us suspect the diagnosis. Amylase production was observed in bone marrow cultures in which 96% of cellularity was composed of plasmablasts. Serum amylase level decreased when chemotherapy was given.
Lopez
J
J
Department of Hematology, Hospital Ramón y Cajal, Madrid, Spain.
Ulibarrena
C
C
Gonzalez-Porque
P
P
Navas
G
G
Roldan
E
E
Cancelas
J A
JA
Perez-Oteyza
J
J
Burgaleta
C
C
García-Laraña
J
J
Sastre
J L
JL
D000368:Aged; D000681:Amylases / Q000096:biosynthesis* / Q000097:blood; D001536:Bence Jones Protein; D001853:Bone Marrow / Q000201:enzymology / Q000473:pathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D009101:Multiple Myeloma / Q000175:diagnosis* / Q000201:enzymology; D010195:Pancreatitis / Q000175:diagnosis*; D010950:Plasma Cells / Q000473:pathology; D012463:Saliva / Q000201:enzymology
D001536:Bence Jones Protein; D000681:Amylases