[Iatrogenic fibrosis in cancerology (2): main etiologies and therapeutic possibilities].
Fibrosis in oncology concerns iatrogenic pathology, after radiotherapy or bleomycin, and also after surgery or neoadjuvant chemotherapy. Specificity of certain etiologic conditions are described in detail. Some therapeutic attitudes are discussed. Corticoids are useful in the management of inflammatory fibrosis attacks. Other drugs under study are used in an attempt to reduce the late fibrotic process, namely liposomal superoxide dismutase.
Delanian
S
S
Service d'oncologie-radiothérapie, hôpital Necker-Enfants-Malades Paris V, France.
Lefaix
J L
JL
Housset
M
M
D000893:Anti-Inflammatory Agents / Q000627:therapeutic use; D000970:Antineoplastic Agents / Q000009:adverse effects*; D000975:Antioxidants / Q000627:therapeutic use; D001761:Bleomycin / Q000009:adverse effects; D005355:Fibrosis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D006801:Humans; D007049:Iatrogenic Disease; D009369:Neoplasms / Q000628:therapy*; D011832:Radiation Injuries / Q000150:complications* / Q000188:drug therapy / Q000473:pathology
D000893:Anti-Inflammatory Agents; D000970:Antineoplastic Agents; D000975:Antioxidants; D001761:Bleomycin