Plasmalemmal caveolae and GPI-anchored membrane proteins.
Caveolae are essential endocytic organelles that use glycosyl-phosphatidyl-inositol (GPI)-anchored membrane proteins to concentrate low molecular weight substances before delivery to the cell. Caveolae and GPI-anchored proteins are uniquely adapted for this task. Recent advances suggest that this endocytic pathway also has an important role in modulating the interaction of a cell with its environment. Many vital functions that occur in this organelle remain to be discovered.
Anderson
R G
RG
Department of Cell Biology and Neuroscience, University of Texas, Southwestern Medical Center, Dallas 75235.
D000818:Animals; D000081247:CSK Tyrosine-Protein Kinase; D015220:Calcium Channels / Q000032:analysis; D002462:Cell Membrane / Q000648:ultrastructure*; D017261:Glycosylphosphatidylinositols / Q000737:chemistry*; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate; D053496:Inositol 1,4,5-Trisphosphate Receptors; D008565:Membrane Proteins / Q000737:chemistry*; D015388:Organelles / Q000648:ultrastructure*; D011505:Protein-Tyrosine Kinases / Q000737:chemistry; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000737:chemistry; D018160:Receptors, Cytoplasmic and Nuclear / Q000032:analysis; D019061:src-Family Kinases
D015220:Calcium Channels; D017261:Glycosylphosphatidylinositols; C506926:ITPR1 protein, human; D053496:Inositol 1,4,5-Trisphosphate Receptors; D008565:Membrane Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D015544:Inositol 1,4,5-Trisphosphate; D011505:Protein-Tyrosine Kinases; D000081247:CSK Tyrosine-Protein Kinase; D016392:Proto-Oncogene Proteins pp60(c-src); D019061:src-Family Kinases; C000631346:CSK protein, human