title: Tumor volume and stage in carcinoma of the prostate detected by elevations in prostate specific antigen.
abstract: We reviewed the surgical specimen from 142 men undergoing radical prostatectomy for prostate cancer detected because of an elevation in serum prostate specific antigen alone. No patient had a palpable abnormality suggestive of cancer. One patient had no identifiable tumor in the radical prostatectomy specimen, 8 (6%) had only a few high power microscopic fields showing cancer, 40 (28%) had an estimated tumor volume of less than 1 cc and 93 (65%) had a tumor volume of greater than 1 cc. Surgical margins were positive in 37 patients (26%) and negative in 105 (73%). Most patients with cancer detected because of modest elevation in prostate specific antigen, even without palpable abnormalities, have a clinically significant tumor volume and are good candidates for radical prostatectomy.
authors.affiliation: Department of Urology, Vanderbilt University Medical Center, Nashville, Tennessee.
authors.forename: R
authors.initials: R
authors.lastname: Scaletscky
authors.forename: M O
authors.initials: MO
authors.lastname: Koch
authors.forename: C W
authors.initials: CW
authors.lastname: Eckstein
authors.forename: S L
authors.initials: SL
authors.lastname: Bicknell
authors.forename: G F
authors.initials: GF
authors.lastname: Gray
authors.forename: J A
authors.initials: JA
authors.lastname: Smith
mesh_terms: D000230:Adenocarcinoma / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D000368:Aged; D014408:Biomarkers, Tumor / Q000097:blood*; D001707:Biopsy, Needle; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D011467:Prostate / Q000473:pathology*; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery
chemical_list: D014408:Biomarkers, Tumor; D017430:Prostate-Specific Antigen