title: Inhibition of human immunodeficiency virus type 1 replication by human interferons alpha, beta and gamma.
abstract: The effect of various preparations of human interferon (HuIFN) upon human immunodeficiency virus (HIV-1) replication in cell lines and primary cultures of peripheral blood lymphocytes (PBL) was investigated. Natural interferon alpha (nHuIFN-alpha) exhibited a much higher inhibitory effect upon HIV-1 replication than did recombinant HuIFN-alpha (rHuIFN-alpha).
authors.affiliation: Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
authors.forename: J K
authors.initials: JK
authors.lastname: Yamamoto
authors.forename: M L
authors.initials: ML
authors.lastname: Kruzel
authors.forename: H
authors.initials: H
authors.lastname: Louie
authors.forename: J A
authors.initials: JA
authors.lastname: Georgiades
mesh_terms: D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology; D016899:Interferon-beta / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D008214:Lymphocytes / Q000382:microbiology; D014779:Virus Replication / Q000187:drug effects*
chemical_list: D016898:Interferon-alpha; D016899:Interferon-beta; D007371:Interferon-gamma; D007372:Interferons