title: Effect of purinergic receptor antagonists suramin and theobromine on tumor-induced angiogenesis in BALB/c mice.
abstract: The purinergic receptor antagonists suramin (SRN) and theobromine (TBR) were examined for their anti-angiogenic activity in BALB/c mice. SRN or TBR were subcutaneously administered to BALB/c mice in doses of 1-125 mg/kg body weight on days 0, 1 and 2 after intradermal inoculation of E14/W lung carcinoma cells. It was shown that SRN and TBR inhibited tumor-related angiogenesis. Accordingly, it may be suggested that purinoceptor antagonists may inhibit neovascularization in tumor growth and metastasis.
authors.affiliation: National Research Institute of Tuberculosis and Lung Diseases, Warsaw.
authors.forename: M
authors.initials: M
authors.lastname: Gil
authors.forename: E
authors.initials: E
authors.lastname: Skopińska-Rózewska
authors.forename: D
authors.initials: D
authors.lastname: Radomska
authors.forename: U
authors.initials: U
authors.lastname: Demkow
authors.forename: H
authors.initials: H
authors.lastname: Skurzak
authors.forename: M
authors.initials: M
authors.lastname: Rochowska
authors.forename: J
authors.initials: J
authors.lastname: Beuth
authors.forename: K
authors.initials: K
authors.lastname: Roszkowski
mesh_terms: D000818:Animals; D002277:Carcinoma / Q000098:blood supply; D007279:Injections, Subcutaneous; D008175:Lung Neoplasms / Q000098:blood supply; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D058914:Purinergic Antagonists; D013498:Suramin / Q000494:pharmacology*; D013805:Theobromine / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D058914:Purinergic Antagonists; D013498:Suramin; D013805:Theobromine