Induction of micronuclei in peripheral blood and bone marrow erythrocytes of rats and mice exposed to 1,3-butadiene by inhalation.
Female CB6F1 mice and male Wistar rats were exposed to different concentrations of 1,3-butadiene (1,3-BD) by inhalation. Micronucleus tests using both peripheral blood erythrocytes and femoral marrow cells of these animals were performed. Cells were stained either using conventional acridine orange (AO) staining or supravitally using AO-coated slides. Dose-dependent increases in the frequency of micronuclei (MN) were observed both in blood and in bone marrow cells in mice. 1,3-BD did not, however, increase the frequency of MN in either blood or bone marrow cells of rats at any of the tested concentrations.
Autio
K
K
Institute of Occupational Health, Laboratory of Molecular and Cellular Toxicology, Helsinki, Finland.
Renzi
L
L
Catalan
J
J
Albrecht
O E
OE
Sorsa
M
M
D000280:Administration, Inhalation; D000818:Animals; D001853:Bone Marrow / Q000473:pathology*; D002070:Butadienes / Q000008:administration & dosage / Q000633:toxicity*; D004307:Dose-Response Relationship, Radiation; D004912:Erythrocytes / Q000187:drug effects* / Q000473:pathology; D005260:Female; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar
D002070:Butadienes; D009153:Mutagens; C031763:1,3-butadiene