title: [Treatment of high malignancy lymphoma with intensive short-term chemotherapy using the MACOP-B regimen].
abstract: We present our results of a MACOP-B regimen in a series of 46 patients with high-grade NHL. The complete remission rate was 74% for patients with advanced stage disease. The excellent tolerance allowed this regimen to be given on an outpatient basis in the majority of cases. The median follow-up for the living patients is 28 months. Although some patients received additional treatment that could influence the results, the predicted DFS (disease-free survival) at 45 months of 57% compares favorably with the best results published so far with more toxic regimens.
authors.affiliation: Service d'hématologie, Hôtel-Dieu, Paris, France.
authors.forename: A
authors.initials: A
authors.lastname: Delmer
authors.forename: F
authors.initials: F
authors.lastname: Bauduer
authors.forename: A
authors.initials: A
authors.lastname: Ruskoné-Fourmestraux
authors.forename: F
authors.initials: F
authors.lastname: Ajchenbaum-Cymbalista
authors.forename: B
authors.initials: B
authors.lastname: Delmas-Marsalet
authors.forename: B
authors.initials: B
authors.lastname: Rio
authors.forename: J P
authors.initials: JP
authors.lastname: Marie
authors.forename: R
authors.initials: R
authors.lastname: Zittoun
mesh_terms: D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000627:therapeutic use; D003520:Cyclophosphamide / Q000627:therapeutic use; D004317:Doxorubicin / Q000627:therapeutic use; D004361:Drug Tolerance; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy*; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D011239:Prednisolone / Q000627:therapeutic use; D011446:Prospective Studies; D015996:Survival Rate; D016896:Treatment Outcome; D014750:Vincristine / Q000627:therapeutic use
chemical_list: D001761:Bleomycin; D014750:Vincristine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011239:Prednisolone; D008727:Methotrexate