Evaluation of the SOS chromotest for detection of genotoxic drugs.
In the present investigation, the SOS Chromotest with E. coli PQ37 was evaluated. The potential of the test to identify genotoxic properties of different cytostatics was examined. Only intercalating agents showed good activity. The SOS Chromotest appeared to be less effective than the Salmonella mutagenicity test in the detection of alkylating agents.
Marczewska
J
J
Drug Institute, Department of Vitamins, Chełmska, Poland.
Chłopkiewicz
B
B
Ejchart
A
A
Koziorowska
J
J
D000477:Alkylating Agents / Q000633:toxicity; D004926:Escherichia coli / Q000235:genetics*; D005069:Evaluation Studies as Topic; D007364:Intercalating Agents / Q000633:toxicity; D009152:Mutagenicity Tests / Q000379:methods*; D009153:Mutagens / Q000633:toxicity*; D013014:SOS Response, Genetics
D000477:Alkylating Agents; D007364:Intercalating Agents; D009153:Mutagens