title: Use of G-CSF alone to mobilize peripheral blood stem cells for collection from children.
abstract: We report the data of 19 children with neuroblastoma (NB) or Ewing's sarcoma (EW) who had peripheral blood stem cells (PBSCs) harvested after mobilization by: (1) cyclophosphamide (CY) + etoposide + G-CSF, (2) CY + GM-CSF, or (3) G-CSF alone. There were no consistent differences in the number of PBSCs collected following these three different mobilization regimens as assessed by CFU-GM. 17 patients were reinfused with PBSCs after myeloablative therapy and had successful haemopoietic recovery. These results show that in children with solid tumours such as NB or EW a sufficient number of PBSCs can be collected after G-CSF alone, and that PBSCs collected following stimulation by G-CSF alone are as effective in reconstituting haemopoiesis as those collected after mobilizing chemotherapy + HGFs.
authors.affiliation: CHRU, Clermont Ferrand, France.
authors.forename: J
authors.initials: J
authors.lastname: Kanold
authors.forename: C
authors.initials: C
authors.lastname: Rapatel
authors.forename: M
authors.initials: M
authors.lastname: Berger
authors.forename: J
authors.initials: J
authors.lastname: Chassagne
authors.forename: P
authors.initials: P
authors.lastname: Lutz
authors.forename: L
authors.initials: L
authors.lastname: de Lumley
authors.forename: D
authors.initials: D
authors.lastname: Plantaz
authors.forename: J P
authors.initials: JP
authors.lastname: Vannier
authors.forename: G
authors.initials: G
authors.lastname: Malpuech
authors.forename: F
authors.initials: F
authors.lastname: Deméocq
mesh_terms: D002648:Child; D002675:Child, Preschool; D003520:Cyclophosphamide / Q000627:therapeutic use; D015672:Erythroid Precursor Cells / Q000502:physiology*; D005047:Etoposide / Q000627:therapeutic use; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D007231:Infant, Newborn; D009447:Neuroblastoma / Q000628:therapy; D012512:Sarcoma, Ewing / Q000628:therapy
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D005047:Etoposide; D003520:Cyclophosphamide