title: Inter-alpha-trypsin inhibitor polymorphism. An improved phenotyping procedure and two new alleles.
abstract: Serum samples treated with chondroitinase ABC and sialidase were investigated for the detection of inter-alpha-trypsin inhibitor (ITI) polymorphism. The improved phenotyping procedure has proved to be the most practical method for ITI phenotyping. The ITI allele frequencies were examined in 2 population samples from Japanese (n = 365) and Thais (n = 150). Three common alleles, ITI*1, ITI*2, and ITI*3 were identified in both populations, but the Thai population showed a higher frequency of ITI*1 and a lower frequency of ITI*3. Two new alleles were found, which were tentatively denoted ITI*Y and ITI*T. The ITI*T allele frequency in Thais was 0.047.
authors.affiliation: Department of Forensic Medicine, Yamagata University School of Medicine, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Harada
authors.forename: K
authors.initials: K
authors.lastname: Umetsu
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
mesh_terms: D000483:Alleles; D000510:Alpha-Globulins / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D005828:Genetics, Population; D006801:Humans; D007564:Japan; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D013785:Thailand; D014361:Trypsin Inhibitors / Q000235:genetics*
chemical_list: D000510:Alpha-Globulins; D014361:Trypsin Inhibitors; C011877:inter-alpha-inhibitor