The reduced expression of HLA-class II antigens and adhesion molecules on monocyte surface after phagocytosis of bacteria.
The reduced expression of HLA-class II antigens (DQ and DP) and some intercellular adhesion molecules (CD11b, CD54 and CD58) was found on monocytes after phagocytosis of bacteria (S. aureus, E. coli, P. aeruginosa, S. enteritidis) but not of latex particles. In contrast, the expression of HLA-DR, CD11a and CD18 was not changed in the course of phagocytosis. The observed changes were related to the amount of phagocytosed bacteria but not to their viability or phagocytosis induced physical changes expressed as the reduction of FSC signal during flow cytometry analysis.
Baran
J
J
Department of Clinical Immunology and Microbiology, Polish-American Institute of Paediatrics, Jagiellonian University Collegium Medicum, Cracow.
Pryjma
J
J
D000818:Animals; D017951:Antigen Presentation; D001419:Bacteria / Q000276:immunology*; D001769:Blood; D002417:Cattle; D015815:Cell Adhesion Molecules / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000276:immunology* / Q000378:metabolism; D018950:Lipopolysaccharide Receptors / Q000502:physiology; D008213:Lymphocyte Activation; D010587:Phagocytosis / Q000235:genetics / Q000502:physiology; D010641:Phenotype; D013601:T-Lymphocytes / Q000276:immunology
D015815:Cell Adhesion Molecules; D000949:Histocompatibility Antigens Class II; D018950:Lipopolysaccharide Receptors