Interaction between substance P and excitatory amino acid receptors in modulation of nociceptive responses of cat spinal dorsal horn neurons.
Co-effects of microelectrophoretic application of 2-amino-5-phosphonovalerate (APV), ketamine, 6,7-dinitroqinoxaline-2,3-dione (DNQX), kynurenate (Kyn) and spantide on 34 spinal dorsal horn neurons were studied. Co-application of spantide and APV or DNQX produced a synergetic inhibition of responses by tibial stimulation in 10/23 and 3/8 neurons, respectively, and also in 3/8 neurons by administration of DL-sodium homocysteate. Spantide enhanced APV- or ketamine-induced inhibition of C responses of 8/19 neurons to sural stimulation, DNQX induced that of 2/4 neurons to gastrocnemius-soleous stimulation (GS), and Kyn induced that to both sural (8/19) and GS (2/4). The results suggest an interaction of SP and NMDA, non-NMDA receptors in processing spinal nociception.
Song
X J
XJ
Shanghai Brain Research Institute, Chinese Academy of Sciences, Shanghai.
Zhao
Z Q
ZQ
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology*; D000818:Animals; D002415:Cats; D004558:Electric Stimulation; D006710:Homocysteine / Q000031:analogs & derivatives / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology; D007736:Kynurenic Acid / Q000494:pharmacology; D009132:Muscles / Q000294:innervation; D064729:Neurokinin-1 Receptor Antagonists; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D009619:Nociceptors / Q000187:drug effects / Q000502:physiology*; D011810:Quinoxalines / Q000494:pharmacology*; D017470:Receptors, Glutamate / Q000187:drug effects / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology*; D018040:Receptors, Neurokinin-1 / Q000502:physiology*; D013116:Spinal Cord / Q000502:physiology*; D013373:Substance P / Q000031:analogs & derivatives* / Q000494:pharmacology; D013497:Sural Nerve / Q000502:physiology
D064729:Neurokinin-1 Receptor Antagonists; D011810:Quinoxalines; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D018040:Receptors, Neurokinin-1; D006710:Homocysteine; C007956:homocysteic acid; D013373:Substance P; C056723:FG 9041; D007649:Ketamine; D015763:2-Amino-5-phosphonovalerate; C042867:spantide; D007736:Kynurenic Acid