title: Nitric oxide--from mediator to medicines.
abstract: Nitric oxide is involved in a wide range of physiological processes in humans and in animals. It controls vascular tone, acts as a neurotransmitter and neuromodulator in the central and peripheral nervous systems and influences the activity of the immune system. Substances that selectively enhance or inhibit its synthesis or removal and modify its effects, are likely to yield interesting therapeutic agents.
authors.affiliation: St George's Hospital Medical School, London.
authors.forename: P
authors.initials: P
authors.lastname: Vallance
authors.forename: S
authors.initials: S
authors.lastname: Moncada
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000502:physiology; D000818:Animals; D004730:Endothelium, Vascular / Q000378:metabolism; D006801:Humans; D009130:Muscle, Smooth / Q000378:metabolism; D009569:Nitric Oxide / Q000096:biosynthesis / Q000276:immunology / Q000502:physiology*; D019001:Nitric Oxide Synthase; D014666:Vasomotor System / Q000502:physiology
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases