Sister-chromatid exchanges in epileptic patients on anticonvulsant therapy.
Sister-chromatid exchanges (SCE) have been studied to analyze genotoxic effects in epileptic patients on anticonvulsant therapy. All patients had an increased frequency of SCE per metaphase (p < 0.001) compared to controls, indicating a genotoxic effect of anticonvulsant drugs.
Sardaş
S
S
University of Gazi, Department of Toxicology, Faculty of Pharmacy, Ankara, Turkey.
Ada
M
M
Karakaya
A E
AE
Aydin
N
N
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000009:adverse effects*; D002648:Child; D002869:Chromosome Aberrations / Q000139:chemically induced / Q000235:genetics*; D025063:Chromosome Disorders; D004827:Epilepsy / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D012854:Sister Chromatid Exchange
D000927:Anticonvulsants