Cardioactive effects of Eremophila alternifolia extracts.
An aqueous extract obtained from the leaves of the traditional Aboriginal medicinal plant Eremophila alternifolia R.Br. (Myoporaceae) was tested on isolated hearts of normotensive rats using the Langendorff heart preparation. A single injection of the extract into the retrograge perfusion solution induced cardioactivity, consisting of a short initial increase in force of contraction (positive inotropism), followed by a decrease in the force (negative inotropism) with simultaneous increase in heart rate (positive chronotropism) and in coronary perfusion rate. These effects were not mediated by alpha- or beta-adrenergic receptors.
Pennacchio
M
M
School of Environmental Biology, Curtin University of Technology, Perth, Australia.
Alexander
E
E
Ghisalberti
E L
EL
Richmond
G S
GS
D000818:Animals; D001315:Australia; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008519:Medicine, Traditional; D009200:Myocardial Contraction / Q000187:drug effects*; D010477:Perfusion; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism
D002316:Cardiotonic Agents; D010936:Plant Extracts; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta