title: Chemoprevention of mammary tumor virus-induced and chemical carcinogen-induced rodent mammary tumors by natural plant products.
abstract: The natural plant products turmeric, beta-carotene, catechin, and betel leaf extract were evaluated for their antitumor effects on mammary tumorigenesis in murine mammary tumor expressing C3H (Jax) mice and in Wistar rats treated with the chemical carcinogen 7-12-dimethylbenz(a)anthracene (DMBA). Administration of turmeric through the diet and of beta-carotene, catechin, and betel leaf extract through the drinking water to virgin female C3H mice resulted in decreased tumor incidence and tumor burden. Administering 5% turmeric in the diet from 2 months of age showed suppression of mammary tumor virus-related reverse transcriptase activity and of preneoplastic changes in the mammary glands. Furthermore, feeding turmeric from 6 months of age resulted in a 100% inhibition of mammary tumors. In the DMBA model of rat mammary tumorigenesis, administration of turmeric, catechin, and betel leaf extract resulted in decreased tumor burden and tumor incidence, and a delay in the onset of mammary tumors.
authors.affiliation: Carcinogenesis Division, Cancer Research Institute, Bombay, India.
authors.forename: S V
authors.initials: SV
authors.lastname: Bhide
authors.forename: M A
authors.initials: MA
authors.lastname: Azuine
authors.forename: M
authors.initials: M
authors.lastname: Lahiri
authors.forename: N T
authors.initials: NT
authors.lastname: Telang
mesh_terms: D015127:9,10-Dimethyl-1,2-benzanthracene; D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D001114:Areca; D002273:Carcinogens; D002338:Carotenoids / Q000627:therapeutic use*; D002392:Catechin / Q000627:therapeutic use*; D030024:Curcuma; D005260:Female; D008325:Mammary Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control* / Q000821:virology; D008324:Mammary Tumor Virus, Mouse / Q000302:isolation & purification; D051379:Mice; D008809:Mice, Inbred C3H; D010936:Plant Extracts / Q000627:therapeutic use*; D010938:Plant Oils / Q000627:therapeutic use; D010946:Plants, Medicinal; D012194:RNA-Directed DNA Polymerase / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D019207:beta Carotene
chemical_list: D016588:Anticarcinogenic Agents; D002273:Carcinogens; D010936:Plant Extracts; D010938:Plant Oils; D019207:beta Carotene; D002338:Carotenoids; D015127:9,10-Dimethyl-1,2-benzanthracene; C012596:turmeric extract; D002392:Catechin; D012194:RNA-Directed DNA Polymerase