One-sided invasion events in homologous recombination at double-strand breaks.
Two classes of homologous recombination mechanism for repair of double-strand breaks (DSBs) have been described in eukaryotes so far. One is conservative and has been explained by the double-strand break repair model (Szostak et al., 1983), whereas the other one is non-conservative and has been explained by the single-strand annealing model (Lin et al., 1984). Here, we will review data supporting the existence of another homologous recombination mechanism for double-strand break repair. We will present the one-sided invasion model that we have proposed to explain this mechanism and discuss its potential implication in various homologous recombination events.
Belmaaza
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Blood Transfusion Services, Canadian Red Cross Society, Montreal, Que.
Chartrand
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D000818:Animals; D004247:DNA / Q000378:metabolism*; D004260:DNA Repair / Q000502:physiology*; D005784:Gene Amplification; D008957:Models, Genetic; D011995:Recombination, Genetic / Q000502:physiology*
D004247:DNA