title: Antitumor, anti-inflammatory and analgesic property of embelin, a plant product.
abstract: Embelin, a plant-based benzoquinone derivative, has been found to exhibit significant antitumor activity in methylcholanthrene-induced fibrosarcoma in albino rats besides enhancing their survival time. The drug also has an appreciable action on pain and inflammation. The changes in DNA, RNA and protein levels in various organs in the tumor-bearing control and the drug-treated animals were also studied.
authors.affiliation: Department of Biochemistry, University of Madras, India.
authors.forename: M
authors.initials: M
authors.lastname: Chitra
authors.forename: E
authors.initials: E
authors.lastname: Sukumar
authors.forename: V
authors.initials: V
authors.lastname: Suja
authors.forename: C S
authors.initials: CS
authors.lastname: Devi
mesh_terms: D000700:Analgesics / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D016227:Benzoquinones / Q000494:pharmacology / Q000627:therapeutic use*; D004247:DNA / Q000378:metabolism; D005354:Fibrosarcoma / Q000188:drug therapy*; D008297:Male; D010146:Pain / Q000188:drug therapy; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D011506:Proteins / Q000378:metabolism; D012313:RNA / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000700:Analgesics; D000894:Anti-Inflammatory Agents, Non-Steroidal; D016227:Benzoquinones; D010936:Plant Extracts; D011506:Proteins; D012313:RNA; D004247:DNA; C010945:embelin