title: The clinical staging of rectal cancer in patients treated by preoperative radiotherapy.
abstract: We describe the results of clinical and (or) surgical staging used by the same surgeon to select a group of 41 patients with advanced rectal cancer for preoperative radiotherapy. Fifteen patients with resectable but advanced rectal cancer were subjected to a short course of radiotherapy (30 Gy in 10 days), immediately followed by resection. High dose preoperative radiotherapy (50-56 Gy in 5 weeks) was administered to 26 patients with borderline resectable or fixed cancer. Adequate resection of the tumour was possible in 21 of these 26 patients 4 weeks after the end of the radiotherapy. A total of 36 patients thus underwent resection after preoperative radiotherapy. No radiotherapy related acute or late morbidity was seen. On 31 December 1992 the results were investigated retrospectively. The median time since entering into the study was 87 months (range 27-141). During the follow-up, pelvic recurrence was detected in six patients; one patient had concomitant distant metastases. The local recurrence free survival at 5 years calculated by the Kaplan-Meier method was 72% (95% CI 58-85). Distant metastases without local recurrence developed in 11 patients. The calculated survival at 5 years was 45% (95% CI 30.5-59).
authors.affiliation: Department of Surgery, University Hospital, Groningen, The Netherlands.
authors.forename: L M
authors.initials: LM
authors.lastname: Buhre
authors.forename: N H
authors.initials: NH
authors.lastname: Mulder
authors.forename: J
authors.initials: J
authors.lastname: Oldhoff
authors.forename: B G
authors.initials: BG
authors.lastname: Szabó
authors.forename: A J
authors.initials: AJ
authors.lastname: Grond
authors.forename: R C
authors.initials: RC
authors.lastname: Verschueren
mesh_terms: D001932:Brain Neoplasms / Q000556:secondary; D003125:Colostomy; D003131:Combined Modality Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000473:pathology; D009367:Neoplasm Staging; D010166:Palliative Care; D010386:Pelvic Neoplasms / Q000473:pathology; D011300:Preoperative Care; D011879:Radiotherapy Dosage; D012004:Rectal Neoplasms / Q000473:pathology* / Q000532:radiotherapy* / Q000601:surgery; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome