[Immunoprophylactic and immunotherapeutic effects of adoptively transferred LAK cells on L615 leukemia suffering mice].
The immunoprophylactic and immunotherapeutic effects of LAK cells transferred adoptively on L615-suffering mice were studied. The results showed that adoptive transfer of LAK cells could increase the survival rate of the mice and prolong the mean survival time of mice with advanced L615 leukemia. IL-2 in appropriate concentration was required in the adoptive immunotherapy, and the combined use of LAK cells with 5-FU or IFN-r had no additive immunotherapeutic effects. The results also revealed that the immunotherapeutic activity of the transferred LAK cells maintained a relatively long period of time in the host body.
Zhao
T H
TH
Department of Microbiology, Chengde Medical College, Hebei.
D000818:Animals; D003131:Combined Modality Therapy; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D016219:Immunotherapy, Adoptive; D007372:Interferons / Q000627:therapeutic use; D007376:Interleukin-2 / Q000276:immunology; D015979:Killer Cells, Lymphokine-Activated / Q000637:transplantation*; D007942:Leukemia, Experimental / Q000276:immunology / Q000517:prevention & control / Q000628:therapy*; D008297:Male; D051379:Mice
D007376:Interleukin-2; D007372:Interferons; D005472:Fluorouracil