The anticlastogenic effect of tocopherol in peritoneal macrophages of benznidazole-treated and ovariectomized mice.
Cytogenetic studies revealed a significant increase in the frequency of structural chromosome aberrations of peritoneal macrophages from hyperimmune Swiss mice after ovariectomy. The administration of the nitroarene benznidazole caused a large number of chromosomal deletions in peritoneal macrophages of sham-ovariectomized animals. The clastogenic effect of benznidazole was much greater in peritoneal macrophages of ovariectomized mice. The anti-oxidant alpha-tocopherol protected the peritoneal macrophages from developing ovariectomy- or benznidazole-induced chromosomal aberrations, thus suggesting free radical damage in these processes.
Lacava
Z G
ZG
Department of Genetics and Morphology, University of Brasilia, DF, Brazil.
Luna
H
H
D000704:Analysis of Variance; D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D005260:Female; D017737:Macrophages, Peritoneal / Q000166:cytology / Q000187:drug effects* / Q000473:pathology; D051379:Mice; D008938:Mitosis / Q000187:drug effects; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D009593:Nitroimidazoles / Q000633:toxicity*; D010052:Ovariectomy; D014344:Trypanocidal Agents / Q000633:toxicity*; D014810:Vitamin E / Q000494:pharmacology*
D016587:Antimutagenic Agents; D009153:Mutagens; D009593:Nitroimidazoles; D014344:Trypanocidal Agents; D014810:Vitamin E; C009999:benzonidazole