[HTLV-I and retinal antigen recognized by T cells].
MT-2 immune but not naive murine (B10.BR) spleen cells responded not only to HTLV-I-infected cell lines but also to retinal antigens of various species by antigen-induced cell proliferation. The phenotype of the responding cells against HTLV-I-infected cell lines as well as retinal antigens was Thy-1.2+, CD4+ and CD8-. The antigen-induced cell proliferation against both HTLV-I-infected cell lines and retinal antigens was clearly inhibited by monoclonal antibodies to CD3, CD4, and MHC class II (I-AK). These data indicate that an epitope of HTLV-I-infected cell lines recognized by the CD4+ T cell is crossreactive to that of retinal antigens.
Fukushima
A
A
Department of Ophthalmology, Kochi Medical School, Japan.
Ueno
H
H
Fujimoto
S
S
D000818:Animals; D000941:Antigens / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology*; D002460:Cell Line; D003429:Cross Reactions; D000939:Epitopes / Q000276:immunology; D005260:Female; D015486:HTLV-I Antigens / Q000276:immunology*; D051379:Mice; D008815:Mice, Inbred Strains; D012160:Retina / Q000276:immunology*; D013045:Species Specificity; D013047:Specific Pathogen-Free Organisms
D000941:Antigens; D000939:Epitopes; D015486:HTLV-I Antigens