Extending the B7 (CD80) gene family.
B7-1 and B7-2 are members of the immunoglobulin superfamily (IgSF) and important regulators of T cell-mediated immune responses. Despite sharing only limited sequence identity, B7-1 and B7-2 bind common receptors, CD28 and CTLA-4, on T cells and have similar functional properties. We have found that the extracellular V (ariable)-like domains of B7-1 and B7-2 share significant sequence similarities with 3 major histocompatibility complex (MHC)-encoded members of the IgSF: butyrophilin, myelin/oligodendrocyte glycoprotein, and the chicken MHC molecule, B-G. This raises the question whether there is an evolutionary link between the MHC, which encodes molecules regulating the antigen specificity of T lymphocyte responses, and B7 molecules, which co-stimulate these responses in antigen-nonspecific fashion.
Linsley
P S
PS
Bristol-Myers Squibb Pharmaceutical Research Institute, Seattle, Washington 98121.
Peach
R
R
Gladstone
P
P
Bajorath
J
J
D000595:Amino Acid Sequence; D015703:Antigens, CD; D018122:B7-1 Antigen / Q000737:chemistry / Q000235:genetics*; D051940:B7-2 Antigen; D000071797:Butyrophilins; D016384:Consensus Sequence; D008562:Membrane Glycoproteins / Q000737:chemistry; D008969:Molecular Sequence Data; D009185:Myelin Proteins / Q000737:chemistry; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D011506:Proteins / Q000737:chemistry; D016415:Sequence Alignment; D013601:T-Lymphocytes / Q000276:immunology
D015703:Antigens, CD; C090881:B-G antigen, Gallus gallus; D018122:B7-1 Antigen; D051940:B7-2 Antigen; D000071797:Butyrophilins; D008562:Membrane Glycoproteins; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D063308:Myelin-Oligodendrocyte Glycoprotein; D011506:Proteins