FR901228, a novel antitumor bicyclic depsipeptide produced by Chromobacterium violaceum No. 968. I. Taxonomy, fermentation, isolation, physico-chemical and biological properties, and antitumor activity.
A novel antitumor bicyclic depsipeptide, FR901228, was isolated from a broth culture of Chromobacterium violaceum No. 968 as colorless prisms and the molecular formula was determined as C24H36N4O6S2. This antibiotic reverted the transformed morphology of a Ha-ras transformant to normal, and exhibited prominent antitumor activities against murine and human tumor cell lines both in vitro and in vivo.
Ueda
H
H
Exploratory Research Laboratories, Fujisawa Pharmaceutical Co., Ltd., Ibaraki, Japan.
Nakajima
H
H
Hori
Y
Y
Fujita
T
T
Nishimura
M
M
Goto
T
T
Okuhara
M
M
D016475:3T3 Cells / Q000187:drug effects; D000230:Adenocarcinoma / Q000188:drug therapy; D000818:Animals; D000900:Anti-Bacterial Agents / Q000096:biosynthesis / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D002277:Carcinoma / Q000188:drug therapy; D002461:Cell Line, Transformed; D002861:Chromobacterium / Q000378:metabolism*; D047630:Depsipeptides; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005285:Fermentation; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D008819:Mice, Nude; D008826:Microbial Sensitivity Tests; D009368:Neoplasm Transplantation; D010456:Peptides, Cyclic; D016559:Tacrolimus / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D047630:Depsipeptides; D010456:Peptides, Cyclic; C087123:romidepsin; D016559:Tacrolimus