[Evaluation of sialic acid levels in serum and degree of sialic acid in gamma-globulin fraction and C-reactive protein in hemodialysed patients].
Regulation of immunological processes associated with complement system activation and immunoglobulin binding depends, among others, on the presence of sialic acids. In haemodialysed patients an increase is found of serum sialic acid level. The purpose of the work was the determination of sialic acid content in gamma-globulins and C-reactive protein, that is in immunologically active glycoproteins. The relationship was also studied between the amount of sialic acids and the level of immune complexes. After examination of a group of 15 haemodialysed patients increased degree of sialization of gamma-globulins was found, as compared with a control group. However, the degree of sialization of C-reactive protein in these patients was decreased in relation to the control group. The changes observed in sialic acid content in gamma-globulins and C-reactive protein in haemodialysed patients modify the function and persistence in circulation of these glycoproteins which may be one of the causes of immunological disturbances in these patients.
Swatowski
A
A
Katedra i Klinika Nefrologii Ak. Med., Lublinie.
Kozioł
M
M
Mierzicki
P
P
Ksiazek
A
A
D000328:Adult; D000936:Antigen-Antibody Complex / Q000032:analysis; D002097:C-Reactive Protein / Q000032:analysis*; D006801:Humans; D006435:Renal Dialysis; D012794:Sialic Acids / Q000097:blood*; D005719:gamma-Globulins / Q000032:analysis*
D000936:Antigen-Antibody Complex; D012794:Sialic Acids; D005719:gamma-Globulins; D002097:C-Reactive Protein