Thioallyl compounds: potent inhibitors of cell proliferation.
S-Allylmercaptocysteine was shown to inhibit vascular smooth-muscle and umbilical endothelial cell proliferation. Inhibition was dose-dependent and affected smooth-muscle cells more than endothelial cells. S-Allylmercaptocysteine was two orders of magnitude more potent than S-allylcysteine and cells grown in its presence showed distinct changes in their phosphorylation compared to untreated controls. Among the proteins whose phosphorylation was altered were GTP-activating protein, protein tyrosine phosphatase-1B and p34cdc2. We conclude that thioallyl compounds, natural constituents of garlic and known to inhibit malignant cells, can also reduce the proliferation of normal cells.
Lee
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Division of Hematology/Oncology, Memorial Hospital of Rhode Island, Pawtucket 02860.
Steiner
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Lin
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D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D001013:Aorta, Thoracic / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D016203:CDC2 Protein Kinase / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects*; D002478:Cells, Cultured; D003545:Cysteine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D020690:GTPase-Activating Proteins; D005737:Garlic; D006801:Humans; D007700:Kinetics; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D010750:Phosphoproteins / Q000378:metabolism*; D010766:Phosphorylation; D019000:Phosphotyrosine; D010946:Plants, Medicinal; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D051381:Rats; D014443:Tyrosine / Q000031:analogs & derivatives / Q000032:analysis; D014471:Umbilical Veins
D000970:Antineoplastic Agents; D020690:GTPase-Activating Proteins; D010750:Phosphoproteins; D011506:Proteins; C086300:S-allylmercaptocysteine; D019000:Phosphotyrosine; D014443:Tyrosine; C065299:S-allylcysteine; D016203:CDC2 Protein Kinase; D017027:Protein Tyrosine Phosphatases; D003545:Cysteine