Expression of the complement membrane attack complex and its inhibitors in Pick disease brain.
The immunohistochemical localization of the complement membrane attack complex (MAC) was examined in Pick disease brain and compared with the distribution of three of its inhibitors, vitronectin, protectin and clusterin. Pick bodies were stained intensely for both the MAC and protectin, weakly for vitronectin, but negatively for clusterin. However, the clusterin antibody intensely stained some pyramidal neurons in affected cortical areas, including ballooned neurons. The present study indicates that a complement-mediated attack is associated with the formation of Pick bodies, and provides further suggestive evidence that clusterin may be a marker for active neuronal degeneration.
Yasuhara
O
O
Kinsmen Laboratory of Neurological Research, University of British Columbia, Vancouver, Canada.
Aimi
Y
Y
McGeer
E G
EG
McGeer
P L
PL
D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD / Q000096:biosynthesis; D018957:CD59 Antigens; D002462:Cell Membrane / Q000378:metabolism; D051152:Clusterin; D015938:Complement Membrane Attack Complex / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D003165:Complement System Proteins / Q000378:metabolism; D003704:Dementia / Q000378:metabolism* / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis; D006023:Glycoproteins / Q000096:biosynthesis; D006624:Hippocampus / Q000378:metabolism / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008562:Membrane Glycoproteins / Q000096:biosynthesis; D008875:Middle Aged; D018832:Molecular Chaperones; D009410:Nerve Degeneration / Q000502:physiology; D009419:Nerve Tissue Proteins / Q000096:biosynthesis; D017966:Pyramidal Cells / Q000378:metabolism; D019096:Vitronectin
D015703:Antigens, CD; D018957:CD59 Antigens; C495242:CLU protein, human; D051152:Clusterin; D015938:Complement Membrane Attack Complex; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D018832:Molecular Chaperones; D009419:Nerve Tissue Proteins; D019096:Vitronectin; D003165:Complement System Proteins