On the scoring of FISH-"painted" chromosome-type exchange aberrations.
The effectiveness of FISH painting for easy detection of radiation-induced chromosome aberrations lies, principally, in the fact that only part of any exchange event is highlighted. However, this partial detection imposes certain limitations when the technique is applied to fundamental studies with primary aberrations, particularly at higher doses, when Complex exchanges are present. Some of these limitations are discussed in this paper.
Savage
J R
JR
MRC Radiobiology Unit, Chilton, Didcot, UK.
Simpson
P
P
D000818:Animals; D002869:Chromosome Aberrations; D006801:Humans; D017404:In Situ Hybridization, Fluorescence