title: Population data and forensic efficiency values for the STR systems HumVWA, HumMBP and HumFABP.
abstract: Population studies were carried out on Caucasians from north-west Germany using the short tandem repeat (STR) systems HumVWA (locus: 12p12-12pter), HumMBP (locus: 18q23-pter) and HumFABP (locus: 4q28-q31). After electrophoresis 9 alleles could be identified for HumVWA in a sample size of 321 unrelated individuals and 4 alleles were found for HumFABP in 106 individuals. For HumMBP-A 10 alleles and for HumMBP-B 7 alleles and 1 intermediate allele were determined in a sample size of 143 individuals. No deviations from Hardy-Weinberg equilibrium could be observed. In a small family study (HumVWA-n = 129; HumMBP-n = 59; HumFABP-n = 48) no new mutations could be found for HumMBP-A and HumFABP whereas 2 mutations were found in HumMBP-B and one mutation in HumVWA. Positive results could be obtained from 1 ng-20 pg (HumVWA, HumFABP) and 1 ng-100 pg (HumMBP) template DNA.
authors.affiliation: Institut für Rechtsmedizin, Münster, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Möller
authors.forename: P
authors.initials: P
authors.lastname: Wiegand
authors.forename: C
authors.initials: C
authors.lastname: Grüschow
authors.forename: S A
authors.initials: SA
authors.lastname: Seuchter
authors.forename: M P
authors.initials: MP
authors.lastname: Baur
authors.forename: B
authors.initials: B
authors.lastname: Brinkmann
mesh_terms: D000483:Alleles; D001801:Blood Stains; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D004252:DNA Mutational Analysis; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005787:Gene Frequency / Q000235:genetics; D005828:Genetics, Population; D005858:Germany; D006801:Humans; D004676:Myelin Basic Protein / Q000235:genetics*; D009363:Neoplasm Proteins; D010641:Phenotype; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*; D025521:Tumor Suppressor Proteins; D014841:von Willebrand Factor / Q000235:genetics*
chemical_list: D002352:Carrier Proteins; C107608:FABP7 protein, human; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D004676:Myelin Basic Protein; D009363:Neoplasm Proteins; D025521:Tumor Suppressor Proteins; D014841:von Willebrand Factor