title: [The mechanisms of the changes in coronary vascular resistance in anaphylactic shock].
abstract: Anaphylactic shock decreased the coronary perfusion pressure, systemic arterial pressure and cardiac output in anesthetised dogs. After combined inhibition of cyclo-oxygenase and lipoxygenase with linoleate-hydroxamic acid, the anaphylactic coronary constriction and morphological cardiac lesions were considerably diminished. Activation of the lipoxygenase pathway seems to play a major role in development of the coronary constriction in anaphylaxis.
authors.forename: A A
authors.initials: AA
authors.lastname: Moĭbenko
authors.forename: L A
authors.initials: LA
authors.lastname: Grabovskiĭ
authors.forename: V N
authors.initials: VN
authors.lastname: Kotsiuruba
authors.forename: V N
authors.initials: VN
authors.lastname: Bulakh
authors.forename: L V
authors.initials: LV
authors.lastname: Tumanovskaia
authors.forename: V I
authors.initials: VI
authors.lastname: Azarov
authors.forename: I A
authors.initials: IA
authors.lastname: Butovich
mesh_terms: D000707:Anaphylaxis / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D003331:Coronary Vessels / Q000503:physiopathology* / Q000648:ultrastructure; D004285:Dogs; D007114:Immunization / Q000379:methods; D007213:Indomethacin / Q000494:pharmacology; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology; D013997:Time Factors; D014655:Vascular Resistance / Q000502:physiology*
chemical_list: D008041:Linoleic Acids; D016718:Arachidonic Acid; C089594:linoleic acid hydroxamate; D019787:Linoleic Acid; D007213:Indomethacin