[Preserving intestinal function after severe burn injury].
To study the changes of the bowel-barrier function and its preservation, we developed a new animal model. A specially bred miniswine (Guizhou species) was used with multiple catheterizations for sampling different blood from portal, inferior mesenteric as will as jugular (central) veins. The animals were sustained with 30% III burns of TBSA 7 days after catheterization and divided randomly into early feeding (EF) group, given a complete diet beginning from 2 hours postburn (n = 6) and delayed feeding (DF) group, given the same diet initiating on 4 days postburn (n = 6). The results indicated that the bowel-barrier function was weakened significantly early postburn so that the translocation of both endotoxin and bacteria from the gut to portal vein was evidently increased. However, improving the intestinal mucosa ischemia, preserving mucosal mass and maintaining bowel-microecological balance through early enteral feeding, as revealed in this study, could enhance the barrier function, and the translocation of bacteria and endotoxin would be thus decreased to some extent.
Shao
H
H
Burn Institute, Southwestern Hospital, Third Military Medical University, Chongqing.
You
Z Y
ZY
Wang
S L
SL
D000818:Animals; D002056:Burns / Q000178:diet therapy / Q000503:physiopathology*; D004247:DNA / Q000378:metabolism; D004731:Endotoxins / Q000097:blood; D004750:Enteral Nutrition; D007413:Intestinal Mucosa / Q000378:metabolism / Q000503:physiopathology*; D008297:Male; D012313:RNA / Q000378:metabolism; D011897:Random Allocation; D013552:Swine; D013556:Swine, Miniature; D013997:Time Factors
D004731:Endotoxins; D012313:RNA; D004247:DNA