title: Severity of abnormality influences decision to terminate pregnancies affected with fetal neural tube defects.
abstract: We examined parental decision concerning pregnancy management in women having fetuses with neural tube defects (NTDs) to determine whether severity of defect or method of detection has an impact on the decision making process. Analysis of decisions by 50 women, whose pregnancies were affected by an isolated neural tube defect (NTD) and characterized by a singleton gestation at 24 gestational weeks or less with normal chromosomal complement (46,XX or 46,XY), were assessed. All 23 women carrying fetuses with anencephaly elected to terminate their pregnancies. Of the 27 women carrying fetuses with spina bifida, 21 (77.8%) elected to terminate their pregnancies and 6 (22.2%) elected to continue their pregnancies. Of the 6 pregnancies that were continued, 4 were initially detected by ultrasonography and 2 were ascertained by maternal serum alpha-fetoprotein screening; defects ranged from 2 to 14 vertebral bodies, and none of the defects were craniad to the T9 level. This is in comparison to 5 of the 21 spina bifida cases that were elective pregnancy terminations, which were characterized by fetal lesions craniad to the T9 level. Severity of NTD thus appears to influence the decision to continue or terminate an affected pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, University of Tennessee, Memphis 38103-2896.
authors.forename: C
authors.initials: C
authors.lastname: Grevengood
authors.forename: L P
authors.initials: LP
authors.lastname: Shulman
authors.forename: J S
authors.initials: JS
authors.lastname: Dungan
authors.forename: P
authors.initials: P
authors.lastname: Martens
authors.forename: O P
authors.initials: OP
authors.lastname: Phillips
authors.forename: D S
authors.initials: DS
authors.lastname: Emerson
authors.forename: R E
authors.initials: RE
authors.lastname: Felker
authors.forename: J L
authors.initials: JL
authors.lastname: Simpson
authors.forename: S
authors.initials: S
authors.lastname: Elias
mesh_terms: D000028:Abortion, Induced; D000653:Amniotic Fluid / Q000737:chemistry; D005260:Female; D005865:Gestational Age; D006801:Humans; D007621:Karyotyping; D009436:Neural Tube Defects / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000473:pathology; D011247:Pregnancy; D037841:Pregnant People; D014463:Ultrasonography; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins