Epidermolytic palmoplantar keratoderma cosegregates with a keratin 9 mutation in a pedigree with breast and ovarian cancer.
Epidermolytic palmoplantar keratosis (EPPK) cosegregates with breast and ovarian cancers in a large French pedigree, raising the possibility that a single genetic mutation might cause these conditions and offering a potential lead to the identification of a hereditary breast/ovarian cancer gene. We have performed linkage analysis and show that the EPPK locus lies on the long arm of chromosome 17 near the type I keratin gene cluster and the proposed breast cancer gene (BRCA1). The type I keratin 9 gene has been partially sequenced in four affected individuals. A single base mutation within the rod domain of the protein cosegregates with EPPK in all affected individuals tested. Although inheritance of this mutation is likely responsible for EPPK, it is unlikely to be the cause of the breast and ovarian cancer.
Torchard
D
D
Laboratoire d'Oncologie Moléculaire, CNRS URA 1158, Institut Gustave Roussy, Villejuif, France.
Blanchet-Bardon
C
C
Serova
O
O
Langbein
L
L
Narod
S
S
Janin
N
N
Goguel
A F
AF
Bernheim
A
A
Franke
W W
WW
Lenoir
G M
GM
D000293:Adolescent; D000328:Adult; D000595:Amino Acid Sequence; D001483:Base Sequence; D001943:Breast Neoplasms / Q000150:complications / Q000235:genetics*; D002886:Chromosomes, Human, Pair 17; D004252:DNA Mutational Analysis; D017931:DNA Primers / Q000235:genetics; D005260:Female; D005602:France; D008040:Genetic Linkage; D006801:Humans; D007633:Keratins / Q000235:genetics*; D007645:Keratoderma, Palmoplantar / Q000150:complications / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010051:Ovarian Neoplasms / Q000150:complications / Q000235:genetics*; D010375:Pedigree; D017354:Point Mutation
D017931:DNA Primers; D007633:Keratins