title: [Hypothyroidism followed by hyperthyroidism under treatment with amiodarone].
abstract: Hypothyroidism followed by hyperthyroidism is described in two patients treated by amiodarone. Euthyroidism was rapidly restored after treatment with antithyroid drugs and potassium perchlorate. The physiopathology of amiodarone-induced hypothyroidism is discussed. Withdrawal of amiodarone is advised in the case of both hypothyroidism and hyperthyroidism.
authors.affiliation: Unité de la thyroïde, Hôpital cantonal, Genève.
authors.forename: R C
authors.initials: RC
authors.lastname: Martin-Du Pan
authors.forename: M O
authors.initials: MO
authors.lastname: Goumaz
authors.forename: C
authors.initials: C
authors.lastname: Perrotet
authors.forename: A
authors.initials: A
authors.lastname: Burger
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000638:Amiodarone / Q000009:adverse effects*; D013956:Antithyroid Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D007037:Hypothyroidism / Q000139:chemically induced* / Q000188:drug therapy / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D010472:Perchlorates / Q000627:therapeutic use; D017680:Potassium Compounds / Q000627:therapeutic use
chemical_list: D013956:Antithyroid Agents; D010472:Perchlorates; D017680:Potassium Compounds; C009006:potassium perchlorate; D000638:Amiodarone