title: Metallic stents in malignant biliary obstruction: results of a multicenter European study of 240 patients.
abstract: OBJECTIVE
  In this retrospective multicenter study, the authors analyzed the clinical efficacy of different metallic stents in the palliative treatment of patients with neoplastic obstructive jaundice.
  
  
  METHODS
  Two hundred forty patients were treated in four European centers. Causes of obstruction were pancreatic carcinoma (n = 84), biliary neoplasm (n = 99), metastases in hilar nodes (n = 34), primary or secondary liver tumors (n = 4), and other tumors (n = 19). A total of 388 metallic stents were used: 300 Wallstents, 35 nitinol Strecker stents, 40 Gianturco-Rosch Z stents, and 13 tantalum Strecker stents.
  
  
  RESULTS
  Overall 25- and 50-week survival rates were 42% and 16%, respectively; the 30-day mortality rate was 14.6%. Two deaths were related to the procedure (0.8%); 19 patients (8%) had major complications. The 25-week patency rate was significantly higher for the nitinol Strecker stents and the Wallstents (78% and 67%, respectively) than for the Z stents and the tantalum Strecker stents (30% and 20%, respectively) (P < .01 and P < .001, respectively). Average patency was 8.3, 5.9, 2.3, and 4.0 months, respectively. Reintervention due to stent obstruction was necessary in 53 patients.
  
  
  CONCLUSIONS
  The Wallstent and the nitinol Strecker stents were the most effective in achieving long-term palliation. Patency was significantly affected by the level of obstruction but not by the type of obstructing tumor.
authors.affiliation: Department of Radiology, University of Rome La Sapienza, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Rossi
authors.forename: M
authors.initials: M
authors.lastname: Bezzi
authors.forename: M
authors.initials: M
authors.lastname: Rossi
authors.forename: A
authors.initials: A
authors.lastname: Adam
authors.forename: N
authors.initials: N
authors.lastname: Chetty
authors.forename: M E
authors.initials: ME
authors.lastname: Roddie
authors.forename: V
authors.initials: V
authors.lastname: Iacari
authors.forename: W
authors.initials: W
authors.lastname: Cwikiel
authors.forename: C L
authors.initials: CL
authors.lastname: Zollikofer
authors.forename: F
authors.initials: F
authors.lastname: Antonucci
mesh_terms: D000368:Aged; D000497:Alloys; D001661:Biliary Tract Neoplasms / Q000150:complications*; D002779:Cholestasis / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D005060:Europe; D005260:Female; D006801:Humans; D008297:Male; D010166:Palliative Care / Q000379:methods*; D010190:Pancreatic Neoplasms / Q000150:complications*; D012189:Retrospective Studies; D015607:Stents; D015996:Survival Rate; D013635:Tantalum; D014025:Titanium
chemical_list: D000497:Alloys; C013616:nitinol; D013635:Tantalum; D014025:Titanium