Anti-inflammatory activities of methanolic extract and alkaloidal components from Corydalis tuber.
A methanolic extract (CM-ext) from Corydalis tuber (Corydalis turtschaninovii Besser forma yanhusuo Y. H. Chou et C. C. Hsu) has been screened for activity in experimental models of inflammation. CM-ext (200 or 500 mg/kg, p.o.) inhibited an increase in vascular permeability in mice induced by acetic acid, and reduced acute paw edema in rats induced by compound 48/80 or carrageenin. CM-ext suppressed the development of adjuvant-induced edema in arthritic rats. CM-ext and its alkaloidal components, dehydrocorydaline, d-glaucine and l-tetrahydrocoptisine inhibited compound 48/80-induced histamine release from peritoneal mast cells of rats. Since these substances from C. tuber were found to be effective in both the acute and chronic phases of inflammation, the crude drug C. tuber can be considered to exert anti-inflammatory activity.
Kubo
M
M
Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
Matsuda
H
H
Tokuoka
K
K
Ma
S
S
Shiomoto
H
H
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001060:Aporphines / Q000494:pharmacology; D001169:Arthritis, Experimental / Q000188:drug therapy; D001600:Berberine Alkaloids / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004487:Edema / Q000188:drug therapy; D005260:Female; D006168:Guinea Pigs; D006636:Histamine Release / Q000187:drug effects; D007082:Ileum / Q000187:drug effects; D066298:In Vitro Techniques; D007249:Inflammation / Q000188:drug therapy*; D008297:Male; D000432:Methanol / Q000737:chemistry; D051379:Mice; D009119:Muscle Contraction / Q000187:drug effects; D009130:Muscle, Smooth / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
D000470:Alkaloids; D000894:Anti-Inflammatory Agents, Non-Steroidal; D001060:Aporphines; D001600:Berberine Alkaloids; D004365:Drugs, Chinese Herbal; C007232:dehydrocorydalin; C014212:stylopine; C005004:glaucine; D000432:Methanol