Diagnostic and therapeutic potential of poly(benzyl L-glutamate).
Poly(benzyl L-glutamate) (PBLG) microcapsules, prepared by a solvent evaporation technique for intravenous injection, are evaluated for their potential use in diagnostic computed tomographic enhancement of liver images. The smaller microcapsules, < 3 microns, loaded with a radiopaque contrast material, ethyl iopanoate (IOPAE), produced prolonged opacification of the liver when delivered intravenously. In vivo tissue distribution studies of PBLG-131I-IOPAE (5 microCi/rat, iv) showed that liver had the highest uptake (percent of injected dose/g of tissue) among other organs 24 h postinjection. An in vitro estrogen receptor assay in pig uteri indicated that PBLG conjugated with estrone did not interfere with estrogen receptor affinity, suggesting the estrogen therapy potential of PBLG-estrone.
Yang
D J
DJ
Division of Diagnostic Imaging, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Li
C
C
Nikiforow
S
S
Gretzer
M B
MB
Kuang
L R
LR
Lopez
M S
MS
Vargas
K
K
Wallace
S
S
D000818:Animals; D002214:Capsules; D003287:Contrast Media / Q000737:chemistry* / Q000493:pharmacokinetics; D004337:Drug Carriers; D004798:Enzymes / Q000097:blood; D004970:Estrone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D005260:Female; D007480:Iopanoic Acid / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D007668:Kidney / Q000000981:diagnostic imaging; D008099:Liver / Q000000981:diagnostic imaging; D010316:Particle Size; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D011817:Rabbits; D051381:Rats; D011960:Receptors, Estrogen / Q000378:metabolism; D013552:Swine; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed
D002214:Capsules; D003287:Contrast Media; D004337:Drug Carriers; D004798:Enzymes; D011960:Receptors, Estrogen; C087640:ethyl iopanoate; C087639:3-aminoethylestrone; C003172:poly-gamma-benzyl-L-glutamate; D011099:Polyglutamic Acid; D004970:Estrone; D007480:Iopanoic Acid