Effect of ibuprofen and diclofenac on the chemotaxis induced by substance P and transforming growth factor-beta on human monocytes and polymorphonuclear cells.
The neuropeptide substance P and the cytokine transforming growth factor-beta are potent chemotactic factors for monocytes or polymorphonuclear cells. They are present in synovial fluid of arthritic patients, and participate in the pathogenesis of arthritis. We investigated, in vitro, the effect of two non-steroidal anti-inflammatory drugs, ibuprofen and diclofenac, on the chemotactic effect of substance P and transforming growth factor-beta at concentrations that can be present in the synovial fluid of arthritic patients. Both drugs decrease the chemotaxis induced by substance P and transforming growth factor-beta, at concentrations that can be easily reached in the synovial fluid during therapy. This event could be involved in the effect of some non-steroidal anti-inflammatory drugs on the development and progress of arthritic disease.
Locatelli
L
L
Department of Pharmacology, School of Medicine, University of Milano, Italy.
Sacerdote
P
P
Mantegazza
P
P
Panerai
A E
AE
D001168:Arthritis / Q000188:drug therapy; D002633:Chemotaxis / Q000187:drug effects*; D004008:Diclofenac / Q000494:pharmacology*; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D066298:In Vitro Techniques; D009000:Monocytes / Q000187:drug effects*; D009504:Neutrophils / Q000187:drug effects*; D013373:Substance P; D013582:Synovial Fluid / Q000276:immunology; D016212:Transforming Growth Factor beta
D016212:Transforming Growth Factor beta; D004008:Diclofenac; D013373:Substance P; D007052:Ibuprofen