VIP enhances and nitric oxide synthase inhibitor reduces survival of rat lungs perfused ex vivo.
VIP delayed the onset of edematous lung injury in isolated perfused rat lungs by 64%, and was more effective than PGI2 in prolonging lung survival ex vivo. While PGI2 increased survival by 37 min versus Krebs/BSA only, VIP increased it by 2 h and 17 min. On the other hand, inhibition of NO. synthase, which protected the lung against oxidant injury caused by paraquat or X/XO,3 actually hastened the onset of injury caused by prolonged perfusion ex vivo, suggesting opposite roles for NO. in different forms of oxidant injury.
Pakbaz
H
H
SUNY at Stony Brook.
Berisha
H
H
Sharaf
H
H
Foda
H D
HD
Said
S I
SI
D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology; D066298:In Vitro Techniques; D008168:Lung / Q000187:drug effects; D019331:NG-Nitroarginine Methyl Ester; D019001:Nitric Oxide Synthase; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion; D051381:Rats; D014660:Vasoactive Intestinal Peptide / Q000494:pharmacology*
D014660:Vasoactive Intestinal Peptide; D001120:Arginine; D011464:Epoprostenol; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D019331:NG-Nitroarginine Methyl Ester