title: Phenotypic characterisation of stellate and giant cells in giant cell fibroma by immunocytochemistry.
abstract: The origin of the stromal, stellate and multinucleate cells in oral giant cell fibroma is unclear. Sixteen giant cell fibromas were stained immunocytochemically for keratin (MNF 116), vimentin, S-100 protein, neurofilaments, glial fibrillary acidic protein, alpha-smooth muscle actin, desmin, CD31 (PECAM-1), CD68, Factor XIIIa and prolyl 4-hydroxylase (5B5). In all cases positive staining was found with vimentin and prolyl 4-hydroxylase, indicating a functional fibroblast phenotype. Reactivity for Factor XIIIa was seen in two cases and in only one was a small number of giant cells stained, suggesting that the majority of oral giant cell fibromas are unrelated to the histologically similar fibrous papule of the nose or facial angiofibroma.
authors.affiliation: Department of Oral Medicine and Pathology, UMDS Guy's Hospital, London, England.
authors.forename: E W
authors.initials: EW
authors.lastname: Odell
authors.forename: C
authors.initials: C
authors.lastname: Lock
authors.forename: T L
authors.initials: TL
authors.lastname: Lombardi
mesh_terms: D000199:Actins / Q000032:analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D000818:Animals; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D015815:Cell Adhesion Molecules / Q000032:analysis; D003893:Desmin / Q000032:analysis; D005260:Female; D005347:Fibroblasts / Q000473:pathology; D005350:Fibroma / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D005870:Giant Cell Tumors / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000737:chemistry / Q000145:classification / Q000473:pathology*; D016900:Neurofilament Proteins / Q000032:analysis; D010641:Phenotype; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011393:Procollagen-Proline Dioxygenase / Q000032:analysis; D009418:S100 Proteins / Q000032:analysis; D017154:Stromal Cells / Q000473:pathology; D011503:Transglutaminases / Q000032:analysis; D014746:Vimentin / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D000199:Actins; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015815:Cell Adhesion Molecules; D003893:Desmin; D005904:Glial Fibrillary Acidic Protein; D007633:Keratins; D016900:Neurofilament Proteins; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D011393:Procollagen-Proline Dioxygenase; D009418:S100 Proteins; D011503:Transglutaminases; D014746:Vimentin; C067980:CD68 antigen, human; D000097382:CD68 Molecule