[Participation of opioid receptor of the kappa-, mu-, and delta-types in regulating the humoral immune response].
The alteration of opioid receptor total binding level as well as ae- and mu-, delta-type distribution has been investigated on the every day of primary and secondary immune response on bovine gamma-globulin. It has been shown that a level of opioid binding measured with [3H]naloxone increased by 6 times during the primary, and by 1.5 times during the secondary immune response on the antigen. A maximal value of opioid receptor activity has been observed at the 7-th and the 5-th days correspondingly, i.e. at the peak of the response. Receptor activity has been measured by displacement of [3H]naloxone with corresponding selective opioid ligand. Growth of the quantity of ae-receptors and decrease of that of mu- and delta-receptor types has been found to take place starting with zero time till 7-th and 5-th days of response development. A reverse picture has been detected during the immune response falling down. Selective ae-ligand stimulated the secretion of specific antibodies to bovine gamma-globulin, whereas mu- and delta-ligands suppressed the antibody production. Functional role of different types of opioid peptides taking part in immune regulation is analyzed.
Dubinin
K V
KV
Zakharova
L A
LA
Alekseev
T A
TA
Khegaĭ
L A
LA
Zaĭtsev
S V
SV
D000818:Animals; D000917:Antibody Formation / Q000502:physiology*; D002417:Cattle; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D009270:Naloxone / Q000378:metabolism; D011485:Protein Binding; D017465:Receptors, Opioid, delta / Q000502:physiology*; D017473:Receptors, Opioid, kappa / Q000502:physiology*; D017450:Receptors, Opioid, mu / Q000502:physiology*; D005719:gamma-Globulins / Q000378:metabolism
D017465:Receptors, Opioid, delta; D017473:Receptors, Opioid, kappa; D017450:Receptors, Opioid, mu; D005719:gamma-Globulins; D009270:Naloxone