Comparison of a lesion-inducing isolate and a non-lesional isolate of Candida albicans in an immunosuppressed rat model of oral candidiasis.
Two distinct strain-related patterns of organism-host interaction on dorsal tongue of immunocompetent rats have been identified for Candida albicans: some isolates induce mucosal lesions, while other isolates penetrate the keratin layer but do not produce a lesion. This study examined the behavior of each of the two types of isolates in a cyclosporin-immunosuppressed rat model. Groups B (normal) and D (cyclosporin) were orally inoculated with a lesion-inducing isolate of C. albicans, while a non-lesional isolate was given to Groups A (normal) and C (cyclosporin). A typical dorsal tongue lesion developed in 4/18 rats in Group B and in 13/16 in Group D (P = 0.00267). No significant difference in infection rate between the normal and cyclosporin-treated animals was seen for the non-lesional isolate. The lack of a host inflammatory response associated with the non-lesional isolate may represent an ecologic advantage for the organism.
Allen
C M
CM
Section of Oral and Maxillofacial Surgery and Pathology, Ohio State University, Columbus 43210.
Saffer
A
A
Meister
R K
RK
Beck
F M
FM
Bradway
S
S
D000818:Animals; D016516:CD4-CD8 Ratio; D002176:Candida albicans / Q000145:classification* / Q000302:isolation & purification / Q000502:physiology*; D002180:Candidiasis, Oral / Q000382:microbiology* / Q000473:pathology; D016572:Cyclosporine; D004463:Ecology; D005260:Female; D006084:Graft Rejection / Q000473:pathology; D016867:Immunocompromised Host; D007633:Keratins; D009061:Mouth Mucosa / Q000382:microbiology / Q000473:pathology; D051381:Rats; D011912:Rats, Inbred ACI; D017207:Rats, Sprague-Dawley; D016038:Skin Transplantation / Q000276:immunology / Q000473:pathology; D006377:T-Lymphocytes, Helper-Inducer / Q000473:pathology; D050378:T-Lymphocytes, Regulatory / Q000473:pathology; D014059:Tongue / Q000382:microbiology* / Q000473:pathology
D007633:Keratins; D016572:Cyclosporine