title: Pseudomonas cepacia empyema necessitatis after lung transplantation in two patients with cystic fibrosis.
abstract: Lung transplantation is an accepted modality for patients with cystic fibrosis (CF) who have end-stage respiratory failure. The postoperative course of these patients is often complicated by serious infections with organisms such as Pseudomonas aeruginosa and Pseudomonas cepacia that may be multiply resistant to conventional antimicrobial agents. We describe two patients with CF who, after double lung transplantation, developed the unusual complication of empyema and empyema necessitatis due to P cepacia that was resistant to all tested antibiotics.
authors.affiliation: Department of Pediatrics, University of Pittsburgh School of Medicine.
authors.forename: B E
authors.initials: BE
authors.lastname: Noyes
authors.forename: M G
authors.initials: MG
authors.lastname: Michaels
authors.forename: G
authors.initials: G
authors.lastname: Kurland
authors.forename: J M
authors.initials: JM
authors.lastname: Armitage
authors.forename: D M
authors.initials: DM
authors.lastname: Orenstein
mesh_terms: D000293:Adolescent; D000900:Anti-Bacterial Agents; D016956:Burkholderia cepacia / Q000187:drug effects / Q000302:isolation & purification; D002648:Child; D003550:Cystic Fibrosis / Q000601:surgery*; D004322:Drainage; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D016724:Empyema, Pleural / Q000382:microbiology* / Q000628:therapy; D006801:Humans; D016040:Lung Transplantation; D008297:Male; D008826:Microbial Sensitivity Tests; D011183:Postoperative Complications / Q000382:microbiology* / Q000628:therapy; D011552:Pseudomonas Infections / Q000209:etiology* / Q000628:therapy
chemical_list: D000900:Anti-Bacterial Agents