A hippocampal protein associated with paraneoplastic neurologic syndrome and small cell lung carcinoma.
A hippocampal 38 kd autoantigen recognized by an autoantibody from the serum of a patient with paraneoplastic limbic encephalitis (PLE) and small cell lung carcinoma (SCLC) was isolated by screening a human hippocampal cDNA library. The 1,991-nucleotide ple21 clone was obtained and the deduced 350-residue protein encoded by the ple21 cDNA clone was found to be highly homologous to the neuron-specific RNA recognition motifs (RRMs)-containing proteins. The homologies were confined to the RRMs and the RRM connecting region. The presence of RRM in the antigenic protein may be important in the pathogenesis of SCLC-associated paraneoplastic neurologic syndrome.
Sakai
K
K
Department of Neurology, Kanazawa Medical University, Ishikawa, Japan.
Gofuku
M
M
Kitagawa
Y
Y
Ogasawara
T
T
Hirose
G
G
Yamazaki
M
M
Koh
C S
CS
Yanagisawa
N
N
Steinman
L
L
D000595:Amino Acid Sequence; D001324:Autoantigens / Q000096:biosynthesis*; D001483:Base Sequence; D018288:Carcinoma, Small Cell / Q000378:metabolism*; D002531:Cerebellum / Q000378:metabolism; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000378:metabolism; D051959:ELAV Proteins; D000067778:ELAV-Like Protein 3; D005625:Frontal Lobe / Q000378:metabolism; D005727:Ganglia, Spinal / Q000378:metabolism; D015723:Gene Library; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000096:biosynthesis*; D010257:Paraneoplastic Syndromes / Q000378:metabolism*; D011061:Poly A / Q000302:isolation & purification / Q000378:metabolism; D012313:RNA / Q000302:isolation & purification / Q000378:metabolism; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D011994:Recombinant Proteins / Q000096:biosynthesis; D017386:Sequence Homology, Amino Acid
D001324:Autoantigens; D018076:DNA, Complementary; D051959:ELAV Proteins; D000067778:ELAV-Like Protein 3; C490264:ELAVL3 protein, human; D009419:Nerve Tissue Proteins; D012333:RNA, Messenger; D016601:RNA-Binding Proteins; D011994:Recombinant Proteins; D011061:Poly A; D012313:RNA