Signal transducing mechanisms in interferon action (a brief review).
Experimental results suggest that protein kinase C (PK-C) may play a substantial role in the action of IFNs, but the precise biochemical pathway remains unknown. Recent evidences reveal the complexity of the mechanism of IFN-action and show that the IFN-alpha, -beta and -gamma induced pathways are overlapping. We briefly discuss what is known in this field and suggest a way in which the contrasting views might be reconciled.
Premecz
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Microbiological Research Group, B. Johan National Institute of Hygiene, Budapest, Hungary.
Markovits
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Földes
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D000818:Animals; D002460:Cell Line; D006801:Humans; D007372:Interferons / Q000494:pharmacology*; D051379:Mice; D011493:Protein Kinase C / Q000378:metabolism*; D015398:Signal Transduction
D007372:Interferons; D011493:Protein Kinase C