[The determination of the antigenic determinant of protective monoclonal antibodies specific to the Francisella tularensis lipopolysaccharide].
F. tularensis lipopolysaccharide (LPS) was studied with the use of monoclonal antibodies (McAb) having protective properties. The binding site of these McAb (IgG2a) is localized on the O-chain of LPS. In contrast to LPS isolated from vaccine strain 15, LPS isolated from F. tularensis cells in the R-form has no O-chains and does not interact with McAb.
Khlebnikov
V S
VS
Golovlev
I R
IR
Tokhtamysheva
N V
NV
Averin
S F
SF
Kulevatskiĭ
D P
DP
Grechko
G K
GK
Averina
A A
AA
Vetchinin
S S
SS
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis* / Q000302:isolation & purification; D000911:Antibodies, Monoclonal / Q000032:analysis* / Q000302:isolation & purification; D000918:Antibody Specificity; D001666:Binding Sites, Antibody / Q000276:immunology; D000939:Epitopes / Q000032:analysis* / Q000302:isolation & purification; D005604:Francisella tularensis / Q000276:immunology* / Q000472:pathogenicity; D006825:Hybridomas / Q000276:immunology; D007158:Immunologic Techniques; D008070:Lipopolysaccharides / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D008807:Mice, Inbred BALB C; D012692:Serial Passage; D014774:Virulence / Q000276:immunology
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000939:Epitopes; D008070:Lipopolysaccharides