title: Effect of aibellin, a peptide antibiotic, on propionate production in the rumen of goats.
abstract: Aibellin was administered in feed to goats (16 to 18 kg of BW) for 12 d. At 80 mg/d, the molar percentage of propionate in rumen fluid increased significantly in 8 d, and the effect lasted for as long as 10 d after administration ceased. Total VFA concentration, protozoa numbers, and NDF digestibility were not depressed significantly at this dosage but were reduced at 100 mg/d with little further increase in the molar percentage of propionate. Therefore, the optimal dosage of aibellin was 80 mg/d under our experimental conditions. In contrast, monensin (30 mg/d) and gramicidin D (60 mg/d) decreased total VFA concentration and protozoa numbers when supplemented to obtain molar percentages of propionate comparable to 80 mg/d of aibellin. From these results, aibellin may be easier and safer to use than monensin and gramicidin D to modify rumen fermentation.
authors.affiliation: Department of Agriculture, Meiji University, Kawasaki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hino
authors.forename: H
authors.initials: H
authors.lastname: Saitoh
authors.forename: T
authors.initials: T
authors.lastname: Miwa
authors.forename: M
authors.initials: M
authors.lastname: Kanda
authors.forename: S
authors.initials: S
authors.lastname: Kumazawa
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000494:pharmacology*; D023181:Antimicrobial Cationic Peptides; D004043:Dietary Fiber; D004063:Digestion / Q000187:drug effects / Q000502:physiology; D056890:Eukaryota / Q000187:drug effects; D005232:Fatty Acids, Volatile / Q000096:biosynthesis; D005285:Fermentation / Q000187:drug effects; D006041:Goats / Q000378:metabolism*; D006096:Gramicidin / Q000494:pharmacology; D008985:Monensin / Q000494:pharmacology; D010455:Peptides; D011422:Propionates / Q000378:metabolism*; D012417:Rumen / Q000378:metabolism* / Q000469:parasitology
chemical_list: D000900:Anti-Bacterial Agents; D023181:Antimicrobial Cationic Peptides; D004043:Dietary Fiber; D005232:Fatty Acids, Volatile; D010455:Peptides; D011422:Propionates; D006096:Gramicidin; C083352:aibellin; D008985:Monensin; C029658:propionic acid