[The neurohumoral status in depression].
In 66 patients with endogenous depression (34 males and 32 females) the concentrations of biogene amine metabolites (vanilmandelic acid (VMA), 5-hydroxyindole acetic acid (5-HIIA), adrenaline and noradrenaline) were examined in 24-hrs urine and hormone in the serum: iodothyronine (T-3), thyroxine (T-4), thyroglobulin (Tg), thyroid-stimulating hormone (TSH), adrenocorticotropic hormone (ACTH), cortisol, prolactin and growth hormones. The examination was performed prior to the initiation of antidepressant therapy and 30 days after its application. The biogene amine metabolites were in reference values before initiation of the therapy, although values of 5-HIIA in women and were closer to the lower limit. Thirty days after the initiation of the antidepressant therapy the statistically significant difference was found at the level of p < 0.05 for adrenalin in men and for VMA and 5-HIIA in women. The hormone values before initiation of the therapy showed increased values of growth hormone, cortisol in men and of thyroglobulin, growth hormone and cortisol in women. At the end of the antidepressant therapy the statistically significant difference was found at the level of p < 0.05 for thyroglobulin and TSH in men and for thyroglobulin, growth hormone and cortisol in women. By comparing the results obtained before and after the antidepressant therapy, the statistically significant difference was found at the level of p < 0.05 for Tg in men and for Tg, T-3, prolactin and growth hormone compared to the women. It has been concluded that in patients with endogenous depression the important role in pathogenesis of the disease have some neurobiogenic disorders.
Preradović
M
M
Vojnomedicinska akademija, Klinika za psihijatriju, Institut za nuklearnu medicinu, Centralna klinicko-hemijska laboratorija.
Savanović
V
V
Lazarov
A
A
Mihajlović
M
M
D000328:Adult; D000368:Aged; D003866:Depressive Disorder / Q000188:drug therapy / Q000378:metabolism*; D004837:Epinephrine / Q000378:metabolism; D005260:Female; D006728:Hormones / Q000378:metabolism; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D018377:Neurotransmitter Agents / Q000378:metabolism*; D009638:Norepinephrine / Q000378:metabolism; D014642:Vanilmandelic Acid / Q000378:metabolism
D006728:Hormones; D018377:Neurotransmitter Agents; D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; D009638:Norepinephrine; D004837:Epinephrine