[Neurophysiologic analysis of the effects of the centrally acting analgesics moradol, tramal and nubain].
The analysis of measurements of early and late components of somatosensory (SSEP) and visual evoked potentials (VEP) in healthy examinees was used to compare the central mechanisms responsible for the analgesic action of moradol, tramal, and nubain. As compared to tramal and nubain, moradol was found to cause a more profound increase in the amplitude of early SSEP components. With this, all three agents were equal in suppressing the amplitude of late SSEP and VEP components. The effects of the drugs on SSEP and VEP, as well as on the sensory and psychoemotional components of human pain perception were also evaluated. The potential features of anesthesiological application of the drugs under study were discussed.
Dolina
O A
OA
Meĭzerov
E E
EE
Blinov
A V
AV
Litovchenko
V S
VS
Koroleva
M V
MV
D000328:Adult; D002077:Butorphanol / Q000494:pharmacology*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009266:Nalbuphine / Q000494:pharmacology*; D012016:Reference Values; D014147:Tramadol / Q000494:pharmacology*
D014147:Tramadol; D009266:Nalbuphine; D002077:Butorphanol