title: Increases in chromosome aberrations and in abnormal sperm morphology in rubber factory workers.
abstract: Subjects working at a rubber plant in a chemicals warehouse or in calandering and bambury units were analyzed for both sperm parameters and structural chromosome aberrations in peripheral blood lymphocytes. Sperm analysis was performed in a group of 24 workers for comparison with fertile (n = 24) and infertile (n = 24) control groups. The statistical analyses of semen volume, vitality and sperm count did not show significant differences between exposed and fertile groups but significant differences were found from the infertile group. A significantly lower proportion of normal sperm head shapes was found in exposed subjects when compared to the fertile group (40.1 vs. 57.8). Seven exposed workers were re-analyzed 1 year later and their sperm parameters did not change. The cytogenetic analysis showed a significant increase (3.90%) in the percentage of cells with aberrations in bambury workers (n = 11). However, no differences were found between calandering workers (n = 8) and control subjects (n = 10). Workplace air samples taken on the day of tissue sampling did not show any increase above the Cuban maximal allowed concentration for benzo[a]pyrene or toluene.
authors.affiliation: Centro Nacional de Investigaciones Científicas, Departamento Productos Naturales, Havana, Cuba.
authors.forename: A
authors.initials: A
authors.lastname: Rendón
authors.forename: A
authors.initials: A
authors.lastname: Rojas
authors.forename: S I
authors.initials: SI
authors.lastname: Fernandez
authors.forename: I
authors.initials: I
authors.lastname: Pineda
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002869:Chromosome Aberrations; D005298:Fertility; D005500:Follow-Up Studies; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure; D012307:Risk Factors; D012408:Rubber; D013076:Sperm Count; D013094:Spermatozoa / Q000002:abnormalities* / Q000648:ultrastructure
chemical_list: D012408:Rubber