The cytoskeleton and membrane transport.
This review summarizes recent studies demonstrating that the actin-based cytoskeleton regulates the activity of many ion channels and transport proteins. Stretch-activated ion channels; channels conductive to chloride, to sodium, and to potassium; electroneutral transport proteins, including the Na(+)-K(+)-2Cl-cotransporter, the Na+/H+ exchanger, and the organic osmolyte transporter; as well as water channels are all regulated by the actin cytoskeleton. Several potential mechanisms whereby the actin cytoskeleton and microtubules regulate transport protein activity are discussed.
Mills
J W
JW
Department of Physiology, Dartmouth Medical School, Hanover, NH 03755-3836.
Schwiebert
E M
EM
Stanton
B A
BA
D000818:Animals; D001692:Biological Transport; D003599:Cytoskeleton / Q000502:physiology*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008565:Membrane Proteins / Q000378:metabolism*; D014867:Water / Q000378:metabolism
D007473:Ion Channels; D008565:Membrane Proteins; D014867:Water