Secondary myelodysplastic syndrome following bone marrow transplantation: report of two cases.
We report two cases of secondary myelodysplastic syndrome (SMDS) which followed successful treatment of a primary malignancy with high-dose chemotherapy supported by reinfusion of autologous stem cells. The SMDS was diagnosed 24 months and 40 months, respectively, following autografting. Both patients lived for 7 months after the diagnosis of SMDS. Our cases support the view that there is an increased risk of SMDS/acute leukemia following autologous marrow transplantation.
Chan
T
T
Department of Haematology and Medical Oncology, Peter MacCallum Cancer Institute, Melbourne, Australia.
Juneja
S
S
Wolf
M
M
Januszewicz
E
E
Cooper
I
I
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001761:Bleomycin / Q000008:administration & dosage; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D004305:Dose-Response Relationship, Drug; D004317:Doxorubicin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D006801:Humans; D002955:Leucovorin / Q000008:administration & dosage; D008223:Lymphoma / Q000188:drug therapy / Q000628:therapy; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D009190:Myelodysplastic Syndromes / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D011241:Prednisone / Q000008:administration & dosage; D011344:Procarbazine / Q000008:administration & dosage; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000628:therapy; D012307:Risk Factors; D018239:Seminoma / Q000188:drug therapy / Q000628:therapy; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000628:therapy; D014182:Transplantation, Autologous; D014750:Vincristine / Q000008:administration & dosage
D001761:Bleomycin; D011344:Procarbazine; D014750:Vincristine; D005047:Etoposide; D004317:Doxorubicin; D003520:Cyclophosphamide; D002955:Leucovorin; D011241:Prednisone; D008727:Methotrexate