title: Localisation of the breast-ovarian cancer susceptibility gene (BRCA1) on 17q12-21 to an interval of < or = 1 cM.
abstract: A breast-ovarian cancer susceptibility gene, BRCA1, which is responsible for disease in approximately 45% of breast cancer families and most families that contain breast and ovarian cancer, has been assigned by genetic linkage to 17q12-21. Here, we report the analysis of three marker-disease recombinants in families that contain breast and ovarian cancer, two of which strongly suggest a location for BRCA1 telomeric to D17S702, a microsatellite polymorphism, and a third which suggests a location centromeric to EDH17B, the gene encoding estradiol-17B dehydrogenase. If the interpretation of these recombinants is correct, the results localise BRCA1 to an interval of < or = 1 cM.
authors.affiliation: Department of Pathology, University of Cambridge, UK.
authors.forename: S A
authors.initials: SA
authors.lastname: Smith
authors.forename: R A
authors.initials: RA
authors.lastname: DiCioccio
authors.forename: J P
authors.initials: JP
authors.lastname: Struewing
authors.forename: D F
authors.initials: DF
authors.lastname: Easton
authors.forename: H H
authors.initials: HH
authors.lastname: Gallion
authors.forename: H
authors.initials: H
authors.lastname: Albertsen
authors.forename: S
authors.initials: S
authors.lastname: Mazoyer
authors.forename: B
authors.initials: B
authors.lastname: Johansson
authors.forename: E
authors.initials: E
authors.lastname: Steichen-Gersdorf
authors.forename: M
authors.initials: M
authors.lastname: Stratton
mesh_terms: D000328:Adult; D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D017931:DNA Primers; D004276:DNA, Satellite; D004960:Estradiol Dehydrogenases / Q000235:genetics; D005260:Female; D020022:Genetic Predisposition to Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010051:Ovarian Neoplasms / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic
chemical_list: D017931:DNA Primers; D004276:DNA, Satellite; D004960:Estradiol Dehydrogenases