title: NASPE Young Investigator Awardee-1993. Computer model of the atrioventricular node predicts reentrant arrhythmias.
abstract: BACKGROUND
  Following atrial premature beats, the AV node may exhibit sustained reentrant tachyarrhythmias, isolated echo beats, or discontinuities in the recovery curve (the plot of conduction time versus atrial cycle length). A computer model was used to examine the hypothesis that spatial variation of AV nodal passive electrical resistance may account for these phenomena.
  
  
  RESULTS
  A computer model of a rectangular lattice of electrotonically linked elements whose ionic kinetics simulated nodal ionic flux was developed. The model showed that there exists a resistance value that minimizes the effective refractory period, because high resistance prevents depolarization of distal elements, while low resistance allows leakage of depolarizing current by electrotonic transmission, preventing activation of proximal elements. High resistances stabilized reentry by slowing conduction. Simulations incorporating equal resistance values between elements predicted increased AV nodal conduction times with increasing prematurity of atrial impulses. A model with a gradual change in resistance between fibers produced discontinuities and tachycardia, but not both simultaneously. Uniform anisotropy produced preferential transverse block, leading to echo beats and "fast-slow" tachycardia, but not recovery curve discontinuities. Nonuniform anisotropy could produce reentry, but tachycardia often occurred without discontinuities. Dividing the lattice into two electrotonically linked parallel pathways with different resistance values ("dual pathway model") predicted recovery curve discontinuities, echo beats, and tachycardia. At critical atrial cycle lengths, only the (high resistance) slow pathway conducted antegradely, while the fast pathway conducted retrogradely, to generate the typical "slow-fast" tachycardia. Responses of the dual pathway model to ablation were consistent with clinical data, including the previous observation of a decrease in fast pathway effective refractory period after slow pathway ablation.
  
  
  CONCLUSIONS
  Differences in passive electrical resistance of electronically linked dual pathways within the AV node may account for functional longitudinal dissociation, reentrant arrhythmias, and responses to catheter ablation therapy.
authors.affiliation: Division of Health Sciences and Technology, Harvard Medical School-Massachusetts Institute of Technology.
authors.forename: C T
authors.initials: CT
authors.lastname: Leffler
authors.forename: J P
authors.initials: JP
authors.lastname: Saul
mesh_terms: D001363:Awards and Prizes; D002304:Cardiac Pacing, Artificial; D003198:Computer Simulation; D006801:Humans; D012955:Societies, Medical; D013611:Tachycardia, Atrioventricular Nodal Reentry; D014481:United States