Pre-eclampsia and serum antibodies to oxidised low-density lipoprotein.
Oxidised low-density lipoprotein (Ox-LDL) has been associated with arterial foam-cell formation, and autoantibodies to Ox-LDL are present in human serum. Lipid peroxidation is enhanced in pre-eclampsia. We assessed whether the titre of IgG autoantibody to an epitope of Ox-LDL, malondialdehyde-conjugated low-density lipoprotein (MDA-LDL), was increased in the sera of pre-eclamptic patients. 16 such patients had significantly higher mean titres of autoantibodies to MDA-LDL than healthy pregnant women (p = 0.028). In a multiple regression model, pre-eclamptic patients still had a significantly higher mean titre (p = 0.048). Enhanced lipid peroxidation may be involved in the foam-cell formation of decidua and in the pathogenesis of pre-eclampsia.
Branch
D W
DW
Department of Obstetrics and Gynecology, University of Utah Health Sciences Center, Salt Lake City.
Mitchell
M D
MD
Miller
E
E
Palinski
W
W
Witztum
J L
JL
D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D016022:Case-Control Studies; D000939:Epitopes / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008077:Lipoproteins, LDL / Q000276:immunology* / Q000378:metabolism; D008315:Malondialdehyde / Q000276:immunology; D010084:Oxidation-Reduction; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy; D012044:Regression Analysis
D001323:Autoantibodies; D000939:Epitopes; D007074:Immunoglobulin G; D008077:Lipoproteins, LDL; D008315:Malondialdehyde