Tenascin: does it play a role in epidermal morphogenesis and homeostasis?
Tenascin is a large glycoprotein of the extracellular matrix. Its complex multidomain structure, along with its unique distribution during embryogenesis, inflammation, wound healing, and tumorigenesis suggest this protein may play a significant role in regulating cell proliferation, migration, and differentiation. In this review I will summarize the structural features of tenascin and its localization in skin and discuss some of the potential roles of tenascin in the regulation of keratinocyte biology.
Lightner
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VA
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710.
D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology*; D004817:Epidermis / Q000254:growth & development*; D016326:Extracellular Matrix Proteins / Q000502:physiology*; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D019063:Tenascin
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D019063:Tenascin