title: Cardioactive effects of Eremophila alternifolia extracts.
abstract: An aqueous extract obtained from the leaves of the traditional Aboriginal medicinal plant Eremophila alternifolia R.Br. (Myoporaceae) was tested on isolated hearts of normotensive rats using the Langendorff heart preparation. A single injection of the extract into the retrograge perfusion solution induced cardioactivity, consisting of a short initial increase in force of contraction (positive inotropism), followed by a decrease in the force (negative inotropism) with simultaneous increase in heart rate (positive chronotropism) and in coronary perfusion rate. These effects were not mediated by alpha- or beta-adrenergic receptors.
authors.affiliation: School of Environmental Biology, Curtin University of Technology, Perth, Australia.
authors.forename: M
authors.initials: M
authors.lastname: Pennacchio
authors.forename: E
authors.initials: E
authors.lastname: Alexander
authors.forename: E L
authors.initials: EL
authors.lastname: Ghisalberti
authors.forename: G S
authors.initials: GS
authors.lastname: Richmond
mesh_terms: D000818:Animals; D001315:Australia; D002316:Cardiotonic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006339:Heart Rate / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008519:Medicine, Traditional; D009200:Myocardial Contraction / Q000187:drug effects*; D010477:Perfusion; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal; D051381:Rats; D017208:Rats, Wistar; D011942:Receptors, Adrenergic, alpha / Q000187:drug effects / Q000378:metabolism; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000378:metabolism
chemical_list: D002316:Cardiotonic Agents; D010936:Plant Extracts; D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta