Expression of the large myelin-associated glycoprotein isoform in rat oligodendrocytes around cerebral infarcts.
An immunohistochemical method that uses two specific antisera-distinguishable myelin-associated glycoprotein (MAG) isoforms showed an expression of large MAG isoform (L-MAG) protein in the oligodendrocyte cytoplasms in the white matter around experimental cerebral infarcts produced by occlusion of the left middle cerebral artery in the rat. L-MAG protein also was detected in the white matter on the contralateral side. This protein appears prior to S-MAG protein in myelination and remyelination in the central and peripheral nervous systems, and is believed to function in myelin formation. Because L-MAG protein has been found in the oligodendrocyte cytoplasm only in the early development period, its appearance in this cytoplasm after ischemic insult is evidence of MAG regeneration.
Ishiguro
H
H
Department of Neurology, Niigata University, Japan.
Inuzuka
T
T
Fujita
N
N
Sato
S
S
Nakano
R
R
Tamura
A
A
Kirino
T
T
Miyatake
T
T
D000818:Animals; D002544:Cerebral Infarction / Q000378:metabolism*; D003593:Cytoplasm / Q000737:chemistry; D007124:Immunoenzyme Techniques; D008297:Male; D008970:Molecular Weight; D009185:Myelin Proteins / Q000032:analysis* / Q000737:chemistry; D018992:Myelin-Associated Glycoprotein; D009836:Oligodendroglia / Q000737:chemistry* / Q000648:ultrastructure; D051381:Rats; D017207:Rats, Sprague-Dawley
D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein