The expression of FMS, KIT and FLT3 in hematopoietic malignancies.
Three receptor molecules, belonging to the class III of receptor tyrosine kinases, namely the receptors for colony-stimulating factor 1, CSF1R (product of the FMS proto-oncogene) and Steel factor, SLFR (product of the KIT proto-oncogene), as well as the recently identified FLT3/FLK2 gene product, appear to play distinct roles in normal hematopoietic differentiation. Their potential role in leukemic hematopoiesis has been approached by expression studies in hematopoietic malignancies, especially in acute leukemias of the myeloid and lymphoid lineages. We present here a review of available data, and discuss the possible significance and potential applications of these results.
Birg
F
F
Laboratoire d'Hématologie Moléculaire, Unité 119 de l'INSERM, Marseille, France.
Rosnet
O
O
Carbuccia
N
N
Birnbaum
D
D
D000208:Acute Disease; D004790:Enzyme Induction; D015973:Gene Expression Regulation, Leukemic; D016298:Hematopoietic Cell Growth Factors / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D006412:Hematopoietic Stem Cells / Q000201:enzymology; D006801:Humans; D007938:Leukemia / Q000201:enzymology* / Q000235:genetics; D016173:Macrophage Colony-Stimulating Factor / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D009363:Neoplasm Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D014411:Neoplastic Stem Cells / Q000201:enzymology; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics / Q000502:physiology; D011956:Receptors, Cell Surface / Q000096:biosynthesis* / Q000235:genetics; D019089:Stem Cell Factor; D051941:fms-Like Tyrosine Kinase 3
D016298:Hematopoietic Cell Growth Factors; C000715470:MAS1 protein, human; D009363:Neoplasm Proteins; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D011956:Receptors, Cell Surface; D019089:Stem Cell Factor; D016173:Macrophage Colony-Stimulating Factor; C497970:FLT3 protein, human; D020794:Receptor Protein-Tyrosine Kinases; D051941:fms-Like Tyrosine Kinase 3