[The effect of different types of recombinant interferon on the induction of 2,5-oligoadenylate synthetase in natural killers and the tumor cells in bladder cancer patients].
Recombinant interferon treatment of donors' and bladder cancer patients' lymphocytes results in activation of natural killer cells which is in correlation with enhanced activity of 2,5-oligoadenylate synthetase in them. The study of sensitivity of bladder cancer cell primary cultures showed that the cells are sensitive to various interferons virtually in all the cases observed as indicated by high synthetase activity. The baseline level of 2,5-oligoadenylate synthetase in tumor cells surpassed that in natural killers from healthy donors which may be related to elevated levels of serum gamma-interferon in the above patients.
Vozianov
A F
AF
Drannik
G N
GN
Verkhatskaia
A A
AA
Zavelevich
M P
MP
Prokhnevskaia
E L
EL
Verkhatskiĭ
P P
PP
Klimenko
I A
IA
D015088:2',5'-Oligoadenylate Synthetase / Q000096:biosynthesis / Q000097:blood / Q000187:drug effects*; D000328:Adult; D002295:Carcinoma, Transitional Cell / Q000201:enzymology / Q000628:therapy*; D002469:Cell Separation; D002478:Cells, Cultured / Q000187:drug effects / Q000201:enzymology; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D007372:Interferons / Q000097:blood / Q000627:therapeutic use*; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000201:enzymology; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects / Q000201:enzymology; D001749:Urinary Bladder Neoplasms / Q000201:enzymology / Q000628:therapy*
D011994:Recombinant Proteins; D007372:Interferons; D015088:2',5'-Oligoadenylate Synthetase