Mycoplasma pneumoniae lacks immunologically-active eukaryotic actin-like antigens.
Mycoplasma pneumoniae was tested for immunologically active eukaryotic actin-like antigens with the use of both polyclonal and monoclonal anti-actin antibodies. No reactivity was demonstrable. Monoclonal antibody OC2F5, which reacts with a M. pneumoniae antigen that co-migrates with actin in one-dimensional sodium dodecyl sulphate polyacrylamide electrophoresis, did not recognize actin. Organism-specific actin antigens are not likely to be responsible for the development of smooth muscle antibodies during acute M. pneumoniae infection.
Cimolai
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Department of Pathology, University of Birtish Columbia, Vancouver, Canada.
D000199:Actins / Q000276:immunology*; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial / Q000276:immunology*; D003429:Cross Reactions; D004591:Electrophoresis, Polyacrylamide Gel; D000939:Epitopes; D009130:Muscle, Smooth / Q000276:immunology; D009177:Mycoplasma pneumoniae / Q000276:immunology*
D000199:Actins; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D000939:Epitopes