[The mechanisms of the changes in coronary vascular resistance in anaphylactic shock].
Anaphylactic shock decreased the coronary perfusion pressure, systemic arterial pressure and cardiac output in anesthetised dogs. After combined inhibition of cyclo-oxygenase and lipoxygenase with linoleate-hydroxamic acid, the anaphylactic coronary constriction and morphological cardiac lesions were considerably diminished. Activation of the lipoxygenase pathway seems to play a major role in development of the coronary constriction in anaphylaxis.
Moĭbenko
A A
AA
Grabovskiĭ
L A
LA
Kotsiuruba
V N
VN
Bulakh
V N
VN
Tumanovskaia
L V
LV
Azarov
V I
VI
Butovich
I A
IA
D000707:Anaphylaxis / Q000097:blood / Q000209:etiology / Q000473:pathology / Q000503:physiopathology*; D000818:Animals; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors / Q000097:blood; D001794:Blood Pressure / Q000502:physiology; D002302:Cardiac Output / Q000502:physiology; D003331:Coronary Vessels / Q000503:physiopathology* / Q000648:ultrastructure; D004285:Dogs; D007114:Immunization / Q000379:methods; D007213:Indomethacin / Q000494:pharmacology; D019787:Linoleic Acid; D008041:Linoleic Acids / Q000494:pharmacology; D013997:Time Factors; D014655:Vascular Resistance / Q000502:physiology*
D008041:Linoleic Acids; D016718:Arachidonic Acid; C089594:linoleic acid hydroxamate; D019787:Linoleic Acid; D007213:Indomethacin