title: Childhood-onset schizophrenia: timely neurobiological research.
abstract: OBJECTIVE
  To review timely research on childhood-onset schizophrenia in view of advances in biological research on, and neurodevelopmental theories of, the later-onset disorder.
  
  
  METHODS
  Research issues are outlined including further clarification of ICD- and DSM-defined childhood schizophrenia, and differentiation from autism "spectrum" and other subtle, chronic developmental disorders. Key neurobiological advances are reviewed for which child studies are relevant and feasible.
  
  
  CONCLUSIONS
  It is anticipated that narrowly defined childhood-onset schizophrenics will constitute a predominantly male population. A high rate of family illness or chromosomal and/or brain developmental abnormalities, which will be instructive regarding the pathophysiology of later-onset schizophrenia, is expected.
authors.affiliation: Child Psychiatry Branch, National Institute of Mental Health, Bethesda, MD 20892.
authors.forename: K
authors.initials: K
authors.lastname: McKenna
authors.forename: C T
authors.initials: CT
authors.lastname: Gordon
authors.forename: J L
authors.initials: JL
authors.lastname: Rapoport
mesh_terms: D017668:Age of Onset; D001288:Attention; D001321:Autistic Disorder / Q000175:diagnosis / Q000523:psychology; D001921:Brain / Q000378:metabolism / Q000503:physiopathology; D001927:Brain Diseases / Q000150:complications / Q000235:genetics; D002675:Child, Preschool; D002869:Chromosome Aberrations; D025063:Chromosome Disorders; D002658:Developmental Disabilities / Q000175:diagnosis / Q000523:psychology; D003937:Diagnosis, Differential; D005260:Female; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D002666:Psychology, Child; D012559:Schizophrenia / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D012737:Sex Factors
chemical_list: D006719:Homovanillic Acid