Heavy metals enhance the reactivation of nitrous acid-treated adenovirus in HeLa cells.
Treatment of HeLa cells with cadmium chloride and zinc chloride increases the survival rate of nitrous acid-treated adenovirus 2 (ade2). This increase is maximal if the time interval between cell treatment and virus infection is delayed by 36 h. The induction process requires protein synthesis only during the 3-h period immediately following treatment; cycloheximide does not prevent the expression of enhanced reactivation if added to the cells after this time.
Piperakis
S M
SM
Department of Biology, National Centre for Scientific Research, Demokritos, Athens, Greece.
D000260:Adenoviruses, Human / Q000187:drug effects / Q000254:growth & development*; D002104:Cadmium / Q000494:pharmacology*; D019256:Cadmium Chloride; D002712:Chlorides / Q000494:pharmacology*; D003513:Cycloheximide / Q000494:pharmacology; D006367:HeLa Cells; D006801:Humans; D009608:Nitrous Acid / Q000494:pharmacology*; D013997:Time Factors; D017967:Zinc Compounds / Q000494:pharmacology*
D002712:Chlorides; D017967:Zinc Compounds; D002104:Cadmium; C016837:zinc chloride; D003513:Cycloheximide; D019256:Cadmium Chloride; D009608:Nitrous Acid