title: The effects of a ring chromosome on the meiotic segregation of other chromosomes in Saccharomyces cerevisiae.
abstract: Meiotic chromosome segregation must occur with high fidelity in order to prevent the generation of aneuploid cells. We have previously described the identification and genetic characterization of a yeast mutant with defects in meiotic sister-chromatid segregation. We attributed the phenotype in this mutant to a dominant allele, which we referred to as SID1-1. These mutants appeared to exhibit high levels of non-disjunction and precocious separation of sister-chromatids of chromosome III, as well as precocious separation of sister chromatids of chromosome VIII and a univalent artificial chromosome. We show here that the unusual meiotic behavior of chromosome III in these strains is due to the presence of a ring III chromosome, rather than a mutant gene. Additional experiments demonstrate that a ring III/rod III pair alters the meiotic segregation of a univalent artificial chromosome.
authors.affiliation: Department of Molecular Biology and Microbiology, Tufts University, Boston, MA 02111, USA.
authors.forename: M
authors.initials: M
authors.lastname: Flatters
authors.forename: R
authors.initials: R
authors.lastname: Maxfield
authors.forename: D
authors.initials: D
authors.lastname: Dawson
mesh_terms: D018244:Chromosomes, Artificial, Yeast; D015825:Chromosomes, Fungal; D004171:Diploidy; D006238:Haploidy; D006579:Heterozygote; D008540:Meiosis; D009154:Mutation; D010641:Phenotype; D011995:Recombination, Genetic; D012303:Ring Chromosomes; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D013172:Spores, Fungal