Methods to study peptides associated with MHC class I molecules.
It is now an accepted fact that peptides of self or non-self origin form an essential component of the MHC class I structure. The peptide component of the heterotrimer contains the essential determinants recognized by the T-cell receptors of cytotoxic T lymphocytes, be it an antigen-specific, alloimmune or autoimmune response. Because of the importance of the recognition process, several methods have been developed to characterize naturally processed peptides presented by the class I molecules.
Joyce
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Department of Microbiology and Immunology, Pennsylvania State University College of Medicine, Milton S Hershey Medical Center, Hershey.
Nathenson
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D000818:Animals; D000939:Epitopes / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D006801:Humans; D007158:Immunologic Techniques; D013058:Mass Spectrometry; D010455:Peptides / Q000276:immunology*; D011854:Radiochemistry; D017421:Sequence Analysis; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D010455:Peptides