title: Influence of surgery on serum concentrations of hyaluronan.
abstract: OBJECTIVE
  To investigate the changes in serum hyaluronan concentrations in response to surgery.
  
  
  METHODS
  A prospective case series evaluating serum hyaluronan concentrations before, during, and after surgery.
  
  
  METHODS
  Operating room and recovery room of a university hospital.
  
  
  METHODS
  Twelve consecutive patients undergoing vascular surgery because of arterial insufficiency of the lower extremities.
  
  
  RESULTS
  Serum hyaluronan concentrations were measured before and after induction of anesthesia and before, during, and after surgery. Routine chemical analyses of blood samples were made before and after surgery. Blood loss and fluid volumes infused were registered. Mean serum hyaluronan concentrations increased from baseline 25 +/- 10 (SD) to 36 +/- 15 micrograms/L (p < .05) during surgery, and increased further at 1 hr after the end of surgery to 52 +/- 38 micrograms/L (p < .001 compared with baseline), but had decreased nearly to baseline levels at 2 hrs postoperatively. A positive correlation was seen between peak hyaluronan concentrations and baseline serum hyaluronan levels (r2 = .73; p < .001), but no strong relationship was seen between serum hyaluronan concentrations and other parameters studied.
  
  
  CONCLUSIONS
  Surgery is accompanied by a small increase in serum hyaluronan concentrations in humans. The major increase is seen in the postoperative period, and is probably due to increased influx of interstitial hyaluronan when the returning muscular tone activates lymph flow.
authors.affiliation: Department of Anesthesiology, University Hospital, Linköping, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Berg
authors.forename: J F
authors.initials: JF
authors.lastname: Hesselvik
authors.forename: T C
authors.initials: TC
authors.lastname: Laurent
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D000768:Anesthesia, General; D001157:Arterial Occlusive Diseases / Q000097:blood* / Q000601:surgery*; D016063:Blood Loss, Surgical; D001810:Blood Volume; D000077324:Crystalloid Solutions; D003911:Dextrans / Q000627:therapeutic use; D005110:Extracellular Space; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood*; D007432:Intraoperative Period; D007552:Isotonic Solutions; D016018:Least-Squares Analysis; D007866:Leg / Q000098:blood supply*; D016014:Linear Models; D008208:Lymphatic System / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000502:physiology; D010952:Plasma Substitutes / Q000627:therapeutic use; D011184:Postoperative Period; D011446:Prospective Studies; D015532:Rehydration Solutions / Q000627:therapeutic use
chemical_list: D000077324:Crystalloid Solutions; D003911:Dextrans; D007552:Isotonic Solutions; D010952:Plasma Substitutes; D015532:Rehydration Solutions; D006820:Hyaluronic Acid