Granulocyte colony-stimulating factor inhibits the endogenous leukotriene production in tumour patients.
Granulocyte colony-stimulating factor (G-CSF) is virtually devoid of inflammatory side-effects when given to patients in therapeutic doses. This is in contrast to other haemopoietic cytokines such as granulocyte-macrophage colony-stimulating factor (GM-CSF) or interleukin-3 (IL-3) which may promote inflammatory reactions by increasing the number and/or activity of monocytes, eosinophils, mast cells and basophils. Inflammatory reactions to GM-CSF and IL-3 appear to be related to an increased formation of leukotrienes, known as potent mediators of allergy and inflammation. Here we report that, in contrast to GM-CSF or IL-3, G-CSF has the potential to inhibit the leukotriene production in vivo. G-CSF may thus act as an anti-inflammatory agent. The differential effects of G-CSF and other haemopoietins on endogenous leukotrienes may be of major clinical significance.
Denzlinger
C
C
Medizinische Klinik III, Klinikum Grosshadern, Germany.
Holler
E
E
Reisbach
G
G
Hiller
E
E
Wilmanns
W
W
D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006801:Humans; D017999:Leukotriene E4 / Q000096:biosynthesis / Q000652:urine*; D008228:Lymphoma, Non-Hodgkin / Q000652:urine*; D008297:Male; D011994:Recombinant Proteins / Q000494:pharmacology; D013736:Testicular Neoplasms / Q000652:urine*
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D017999:Leukotriene E4