title: Epithelial deposits of immunoglobulin G1 and activated complement co-localize with the "M(r) 40kD" putative auto-antigen in ulcerative colitis.
abstract: In conclusion, the "M(r) 40kD" antigen is expressed on the apical face of colonic enterocytes often in spatial relation to immune complexes in active UC, apparently targeting an IgG1-mediated autoimmune attack. Thus, our findings support the notion that an autoimmune response to the "M(r) 40kD" antigen, with local production of specific IgG1, is a possible immunopathological mechanism(s) in UC.
authors.affiliation: Laboratory for Immunohistochemistry and Immunopathology (LIIPAT), University of Oslo, National Hospital, Norway.
authors.forename: T S
authors.initials: TS
authors.lastname: Halstensen
authors.forename: K M
authors.initials: KM
authors.lastname: Das
authors.forename: P
authors.initials: P
authors.lastname: Brandtzaeg
mesh_terms: D001324:Autoantigens / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism*; D003093:Colitis, Ulcerative / Q000276:immunology* / Q000473:pathology; D003106:Colon / Q000276:immunology / Q000473:pathology; D003167:Complement Activation; D003165:Complement System Proteins / Q000302:isolation & purification / Q000378:metabolism*; D006801:Humans; D018928:Immunity, Mucosal; D007074:Immunoglobulin G / Q000302:isolation & purification / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000276:immunology* / Q000473:pathology; D008970:Molecular Weight; D014018:Tissue Distribution
chemical_list: D001324:Autoantigens; D007074:Immunoglobulin G; D003165:Complement System Proteins