Todralazine influence upon the mutagenicity of some direct- and indirect-acting mutagens.
Todralazine decreased the mutagenic activity of tested direct- and indirect-acting mutagens. Despite the marked differences between efficient todralazine doses (ED50) it was observed that, in the case of tested indirect mutagens as well as in some of the direct mutagens, the decrease of mutagenicity by todralazine was very strong, exceeding 80% in some cases.
Gasiorowski
K
K
Medical Academy, Department of Basic Medical Sciences, Wroclaw, Poland.
Szyba
K
K
Urban
J
J
D015112:4-Nitroquinoline-1-oxide / Q000633:toxicity; D015127:9,10-Dimethyl-1,2-benzanthracene / Q000037:antagonists & inhibitors; D000585:Aminacrine / Q000633:toxicity; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001386:Azides / Q000037:antagonists & inhibitors; D001564:Benzo(a)pyrene / Q000037:antagonists & inhibitors; D001711:Biotransformation; D003630:Daunorubicin / Q000037:antagonists & inhibitors; D004305:Dose-Response Relationship, Drug; D008741:Methyl Methanesulfonate / Q000037:antagonists & inhibitors; D008748:Methylcholanthrene / Q000633:toxicity; D008862:Microsomes, Liver / Q000201:enzymology; D016685:Mitomycin / Q000037:antagonists & inhibitors; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D019810:Sodium Azide; D014032:Todralazine / Q000494:pharmacology*
D016587:Antimutagenic Agents; D001386:Azides; D009153:Mutagens; D001564:Benzo(a)pyrene; D016685:Mitomycin; D008748:Methylcholanthrene; D015112:4-Nitroquinoline-1-oxide; D015127:9,10-Dimethyl-1,2-benzanthracene; D000585:Aminacrine; D019810:Sodium Azide; D008741:Methyl Methanesulfonate; D014032:Todralazine; D003630:Daunorubicin