Expression of thrombospondin-1 (TSP1) and its receptor (CD36) in healthy and diseased human skin.
In the present study, an analysis was made of the expression pattern of thrombospondin-1 (TSP1) and its receptor (CD36) in skin biopsies obtained from healthy volunteers and from patients with lichen planus, lupus erythematosus, cutaneous T-cell lymphoma and psoriasis vulgaris. Using monoclonal antibodies against TSP1 in biopsies from the healthy volunteers and from both clinically involved and uninvolved skin of the patients, a specific peroxidase-positive reaction was detected around the sweat glands in the dermis. In all cases investigated, the CD36-positive lesional keratinocytes remained TSP1-negative. These findings favour the hypothesis that CD36-positive keratinocytes might have some functional relevance via oxidized low-density lipoprotein and/or collagen fibrils, without any connection with TSP1.
Bégány
A
A
Department of Dermatology, University Medical School Debrecen, Hungary.
Simon
M
M
Dehmel
N
N
Hunyadi
J
J
D015703:Antigens, CD / Q000032:analysis*; D018955:CD36 Antigens; D015815:Cell Adhesion Molecules / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008010:Lichen Planus / Q000378:metabolism; D008180:Lupus Erythematosus, Systemic / Q000378:metabolism; D016399:Lymphoma, T-Cell / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000032:analysis*; D011565:Psoriasis / Q000378:metabolism; D016024:Receptors, Cytoadhesin / Q000032:analysis*; D012867:Skin / Q000378:metabolism*; D012871:Skin Diseases / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism; D019699:Thrombospondins
D015703:Antigens, CD; D018955:CD36 Antigens; D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D016024:Receptors, Cytoadhesin; D019699:Thrombospondins