Disposition of maternal ketoconazole in breast milk.
Infant exposure to ketoconazole in human milk was calculated to be 0.4% on average (maximum 1.4%) of those expected from therapeutic doses given directly to infants. Potential risk of adverse reactions from this low exposure level seem to be outweighed by the benefits of breast-feeding.
Moretti
M E
ME
Department of Pediatrics, Hospital for Sick Children, Toronto, Ontario, Canada.
Ito
S
S
Koren
G
G
D000328:Adult; D001942:Breast Feeding; D005260:Female; D006801:Humans; D007223:Infant; D007654:Ketoconazole / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008895:Milk, Human / Q000737:chemistry*; D009181:Mycoses / Q000188:drug therapy*; D013997:Time Factors
D007654:Ketoconazole