Dosimetry and toxicity of samarium-153-EDTMP administered for bone pain due to skeletal metastases.
Palliation of bone pain in patients with cancer metastatic to bone is being evaluated in several cancer centers by the administration of the bone-seeking phosphonate ethylenediaminetetramethylenephosphonic acid (EDTMP) chelated with the beta particle-emitting radionuclide 153Sm.


METHODS
In this study, 153Sm-EDTMP was intravenously injected into 19 patients over a 1-min period. Patients received up to four injections of 18.5 MBq (0.5 mCi) or 37 MBq (1.0 mCi) per kilogram of body weight. Skeletal retention was calculated from urinary excretion.


RESULTS
No uptake of 153Sm-EDTMP in nonskeletal tissues was observed in whole-body gamma camera images. The mean skeletal uptake for all patients was 54% +/- 16% of the injected dose (%ID). This resulted in the bone marrow receiving 89 cGy/GBq +/- 27 cGy/GBq (3.28 cGy/mCi +/- 0.99 cGy/mCi), with calculated marrow doses ranging from 27 cGy to 338 cGy. For each patient, the estimated radiation absorbed dose to the marrow was correlated to the percent decrease in platelet number, ranging from 7.4% to 78.9%.


CONCLUSIONS
Since the deviation of uptake between the four injections for a given patient (7.6% ID) was less than the deviation for all patients (16% ID), the initial dose may be used to estimate the skeletal uptake for the remaining doses. These radiation dose estimates permit patients at risk to be identified prior to reaching myelotoxicity and develop dose-response models. Thirteen patients (68%) reported significant pain relief from this radionuclide therapy. Bone pain appears to be alleviated by 153Sm-EDTMP with limited red marrow doses and no toxic effects in other organs.
Bayouth
J E
JE
Department of Radiation Physics, University of Texas M.D. Anderson Cancer Center, Houston 77030.
Macey
D J
DJ
Kasi
L P
LP
Fossella
F V
FV
D001853:Bone Marrow / Q000187:drug effects; D001859:Bone Neoplasms / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging; D002614:Chelating Agents / Q000627:therapeutic use; D006801:Humans; D009943:Organophosphorus Compounds / Q000009:adverse effects / Q000627:therapeutic use*; D010146:Pain / Q000209:etiology / Q000532:radiotherapy*; D010166:Palliative Care; D011868:Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use*; D011877:Radionuclide Imaging; D011879:Radiotherapy Dosage; D012493:Samarium / Q000009:adverse effects / Q000627:therapeutic use*
D002614:Chelating Agents; D009943:Organophosphorus Compounds; D011868:Radioisotopes; C018940:(ethylenedinitrilo)-tetramethylenephosphonic acid; D012493:Samarium