title: Inducible nitric oxide synthase activity in hepatocytes is dependent on the coinduction of tetrahydrobiopterin synthesis.
authors.affiliation: University of Pittsburgh, Department of Surgery, PA 15261.
authors.forename: M
authors.initials: M
authors.lastname: Di Silvio
authors.forename: D A
authors.initials: DA
authors.lastname: Geller
authors.forename: S S
authors.initials: SS
authors.lastname: Gross
authors.forename: A
authors.initials: A
authors.lastname: Nussler
authors.forename: P
authors.initials: P
authors.lastname: Freeswick
authors.forename: R L
authors.initials: RL
authors.lastname: Simmons
authors.forename: T R
authors.initials: TR
authors.lastname: Billiar
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives / Q000494:pharmacology; D001708:Biopterins / Q000031:analogs & derivatives* / Q000096:biosynthesis; D002478:Cells, Cultured; D016207:Cytokines / Q000494:pharmacology; D004790:Enzyme Induction; D006136:GTP Cyclohydrolase / Q000096:biosynthesis*; D015870:Gene Expression; D007042:Hypoxanthines / Q000494:pharmacology; D008070:Lipopolysaccharides / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D008727:Methotrexate / Q000494:pharmacology; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D019323:omega-N-Methylarginine
chemical_list: D016207:Cytokines; D007042:Hypoxanthines; D008070:Lipopolysaccharides; D012333:RNA, Messenger; D001708:Biopterins; D019323:omega-N-Methylarginine; D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D006136:GTP Cyclohydrolase; C017202:2,4-diaminohypoxanthine; C003402:sapropterin; D008727:Methotrexate