Protein kinase regulation: insights from crystal structure analysis.
The crystal structures of three protein kinases in various states of activity have recently been determined. Analysis of these structures is providing unprecedented insight into the precise atomic movements underlying protein kinase regulation.
Morgan
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Department of Physiology, University of California, San Francisco 94143-0444.
De Bondt
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D000595:Amino Acid Sequence; D000818:Animals; D042846:CDC2-CDC28 Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000737:chemistry; D002645:Chickens; D017124:Conserved Sequence; D017868:Cyclic AMP-Dependent Protein Kinases / Q000737:chemistry; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases; D006706:Homeostasis; D006801:Humans; D051379:Mice; D019950:Mitogen-Activated Protein Kinase 1; D008969:Molecular Sequence Data; D011494:Protein Kinases / Q000737:chemistry* / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases; D017433:Protein Structure, Secondary; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000737:chemistry; D051381:Rats; D011972:Receptor, Insulin / Q000737:chemistry; D017386:Sequence Homology, Amino Acid; D015398:Signal Transduction
D011494:Protein Kinases; D011972:Receptor, Insulin; D016392:Proto-Oncogene Proteins pp60(c-src); D017346:Protein Serine-Threonine Kinases; D017868:Cyclic AMP-Dependent Protein Kinases; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D042846:CDC2-CDC28 Kinases; C495894:CDK2 protein, human; C495893:Cdk2 protein, mouse; C495892:Cdk2 protein, rat; D051357:Cyclin-Dependent Kinase 2; D018844:Cyclin-Dependent Kinases; D019950:Mitogen-Activated Protein Kinase 1