Influence of hexachlorocyclohexane on phosphoinositides in rat erythrocyte membranes and brain.
Single exposure of rats to hexachlorocyclohexane (100 mg/kg) did not cause any significant change in phosphoinositide levels in rat erythrocyte membrane and cerebrum (fore brain) 2 or 24 h after exposure. However, the phosphoinositide turnover and generation of second messengers from phosphoinositides were increased in the treated erythrocyte membranes as judged from a marked increase in the incorporation of [2-3H]inositol into phosphoinositides 24 h after the treatment. A significant decrease in phosphatidylinositol (PI), phosphatidylinositol 4-phosphate (PIP) and phosphatidylinositol 4,5-bisphosphate (PIP2) was observed in the erythrocyte membrane and cerebrum of rats repeatedly exposed to the pesticide for 3 or 6 months. This drastic reduction in phosphoinositide levels suggests adverse effects on vital membrane and cell functions modulated by phosphoinositides.
Agrawal
D
D
Industrial Toxicology Research Centre, Lucknow, India.
Subramoniam
A
A
Afaq
F
F
D000818:Animals; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D005260:Female; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D010716:Phosphatidylinositols / Q000378:metabolism*; D016548:Prosencephalon / Q000187:drug effects / Q000378:metabolism*; D051381:Rats
D010716:Phosphatidylinositols; D001556:Hexachlorocyclohexane