Cell adhesion. Fibronectin and integrin knockouts come unstuck.
Mice with homozygous null mutations in the genes encoding fibronectin or the alpha5 integrin subunit die as embryos. The types of embryonic defect confirm some ideas about fibronectin function but cast doubt on others.
Watt
F M
FM
Keratinocyte Laboratory, Imperial Cancer Research Fund, London, UK.
Hodivala
K J
KJ
D000595:Amino Acid Sequence; D000818:Animals; D002448:Cell Adhesion / Q000235:genetics / Q000502:physiology*; D005314:Embryonic and Fetal Development; D005353:Fibronectins / Q000235:genetics / Q000502:physiology; D016023:Integrins / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D008969:Molecular Sequence Data; D009154:Mutation; D009842:Oligopeptides / Q000235:genetics; D017469:Receptors, Fibronectin
D005353:Fibronectins; D016023:Integrins; D009842:Oligopeptides; D017469:Receptors, Fibronectin; C047981:arginyl-glycyl-aspartic acid