[Role of interleukin-2 receptor in mitogenic action of C-reactive protein on lymphocytes].
There is evidence that native pentameric C-reactive protein (CRP) and its nonmitogenic monomeric subunits compete with IL 2 at the level of lymphocyte proliferation triggering and block IL 2 receptors due to structural and antigenic similarities between CRP and IL 2. The mechanisms of mitogenic action of CRP and evolutionary bases of the CRP-cytokine system relationship are discussed.
Nazarov
P G
PG
Polevshchikov
A V
AV
D002097:C-Reactive Protein / Q000276:immunology / Q000502:physiology*; D002455:Cell Division; D006801:Humans; D007376:Interleukin-2 / Q000276:immunology / Q000494:pharmacology / Q000502:physiology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology / Q000502:physiology*; D015375:Receptors, Interleukin-2 / Q000276:immunology / Q000502:physiology*; D011994:Recombinant Proteins / Q000494:pharmacology
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D011994:Recombinant Proteins; D002097:C-Reactive Protein