Pentacyclic triterpenes derived from Maprounea africana are potent inhibitors of HIV-1 reverse transcriptase.
Pengsuparp
T
T
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612.
Cai
L
L
Fong
H H
HH
Kinghorn
A D
AD
Pezzuto
J M
JM
Wani
M C
MC
Wall
M E
ME
D001565:Benzoates / Q000302:isolation & purification* / Q000494:pharmacology; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000201:enzymology*; D015498:HIV-2 / Q000201:enzymology; D010946:Plants, Medicinal / Q000737:chemistry*; D012194:RNA-Directed DNA Polymerase; D018894:Reverse Transcriptase Inhibitors; D013329:Structure-Activity Relationship; D013636:Tanzania; D014315:Triterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D001565:Benzoates; D018894:Reverse Transcriptase Inhibitors; D014315:Triterpenes; C087541:1-hydroxymaprounic 3-p-hydroxybenzoate; C087542:2-hydroxymaprounic acid 2,3-bis(4-hydroxybenzoate); C072416:reverse transcriptase, Human immunodeficiency virus 2; D054303:HIV Reverse Transcriptase; D012194:RNA-Directed DNA Polymerase