title: Messenger plasticity in primary sensory neurons following axotomy and its functional implications.
abstract: Following peripheral axotomy, long-lasting changes in the expression of neuropeptides and their receptors in primary sensory neurons are observed. These changes involve the downregulation of the excitatory peptides substance P and calcitonin gene-related peptide and the upregulation of the inhibitory peptides neuropeptide tyrosine and galanin, resulting in a reduction of transmission in the dorsal horn. The changes observed are thought to represent adaptive responses to limit the consequences of peripheral nerve damage to the organism as a whole and to promote survival and recovery of the individual neuron.
authors.affiliation: Dept of Neuroscience, Huddinge University Hospital, Karolinska Institute, Stockholm, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Hökfelt
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: Z
authors.initials: Z
authors.lastname: Wiesenfeld-Hallin
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D001369:Axons; D005786:Gene Expression Regulation; D008253:Macaca mulatta; D008959:Models, Neurological; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D009475:Neurons, Afferent / Q000378:metabolism*; D009479:Neuropeptides / Q000096:biosynthesis* / Q000235:genetics; D009569:Nitric Oxide / Q000502:physiology; D010146:Pain / Q000503:physiopathology; D059348:Peripheral Nerve Injuries; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017981:Receptors, Neurotransmitter / Q000096:biosynthesis* / Q000235:genetics
chemical_list: D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D012333:RNA, Messenger; D017981:Receptors, Neurotransmitter; D009569:Nitric Oxide