Fatal cerebral infarction in an asymptomatic young patient with primary antiphospholipid syndrome.
An 18-year-old woman with primary antiphospholipid syndrome developed a major cerebral infarction leading to brain death despite intensive treatment with steroids, urokinase, glyceol and heparin. Fatal strokes associated with this syndrome are rare. A computed tomographic scan of the brain suggested occlusion of the main trunk of the right middle cerebral artery. The titer of antibodies against cardiolipin/ beta 2-glycoprotein I complex in serum was extremely high.
Muneta
S
S
Department of Internal Medicine, Matsuyama Red Cross Hospital, Ehime, Japan.
Yokota
E
E
Watanabe
S
S
Matsumoto
I
I
Yamashita
Y
Y
D000293:Adolescent; D016736:Antiphospholipid Syndrome / Q000150:complications*; D001053:Apolipoproteins / Q000276:immunology; D001323:Autoantibodies / Q000032:analysis; D002308:Cardiolipins / Q000276:immunology; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000209:etiology*; D017809:Fatal Outcome; D005260:Female; D006023:Glycoproteins / Q000276:immunology; D006801:Humans; D014057:Tomography, X-Ray Computed; D053482:beta 2-Glycoprotein I
D001053:Apolipoproteins; D001323:Autoantibodies; D002308:Cardiolipins; D006023:Glycoproteins; D053482:beta 2-Glycoprotein I