Immunodeficiency due to a faulty interaction between T cells and B cells.
The identification of the ligand for CD40, gp39, which is expressed on the membrane of activated CD4+ T-helper cells, has sparked intense investigation into the roles of this molecule in physiological B-cell activation. Recently, it has become clear that some human immunodeficiencies, such as X-linked hyper IgM syndrome and common variable immunodeficiency are linked to mutations in the gp39 gene or are a result of defective expression of gp39, leading to suboptimal, or a lack of, B-cell activation by T-helper cells.
Laman
J D
JD
Department of Immunological and Infectious Diseases, Institute of Health and Prevention TNO, Rijswjk, The Netherlands.
Claassen
E
E
Noelle
R J
RJ
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D019013:CD40 Antigens; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000276:immunology*; D008024:Ligands; D013601:T-Lymphocytes / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D019013:CD40 Antigens; D008024:Ligands; D014409:Tumor Necrosis Factor-alpha