Alteration of substance P-mediated vasodilatation and sympathetic vasoconstriction in the rat knee joint by adjuvant-induced inflammation.
The effects of nerve stimulation and topical administration of substance P (SP) on the blood flow supplying the rat knee joint were measured using laser Doppler perfusion imaging. A comparison was made between the responses found in normal knees and those observed in a group of animals with unilateral chronic inflammation induced by intra-articular injection of Freund's adjuvant, 1 week prior to experimentation. In control knees, nerve stimulation produced a frequency-dependent vasoconstriction over the range of 5-30 Hz and application of SP caused a dose-dependent vasodilatation. Chronically inflamed joints showed virtually no response to either nerve stimulation or SP application, suggesting a radical alteration in sympathetic and neuropeptidergic actions.
McDougall
J J
JJ
Institute of Physiology, University of Glasgow, UK.
Karimian
S M
SM
Ferrell
W R
WR
D000818:Animals; D001169:Arthritis, Experimental / Q000473:pathology / Q000503:physiopathology*; D004558:Electric Stimulation; D005620:Freund's Adjuvant; D006614:Hindlimb / Q000098:blood supply / Q000473:pathology* / Q000502:physiology; D007091:Image Processing, Computer-Assisted; D007270:Injections, Intra-Articular; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow / Q000187:drug effects / Q000502:physiology; D013373:Substance P / Q000494:pharmacology / Q000502:physiology*; D013564:Sympathetic Nervous System / Q000503:physiopathology*; D014661:Vasoconstriction / Q000502:physiology*; D014664:Vasodilation / Q000502:physiology*
D013373:Substance P; D005620:Freund's Adjuvant