Common structural patterns of cytokine outer surfaces.
Schemes of the four-helix bundle surfaces of interleukin-2, -4, -5, granulocyte/macrophage-, granulocyte-, macrophage-colony-stimulating factor, interferon-beta, -gamma and growth hormone were designed. All cytokines appeared to have the structurally similar "holes" on the surfaces. They were suggested to serve as a part of the main receptor-binding sites.
Denesyuk
A I
AI
Institute of Immunology, Moscow Region, Russia.
Zav'yalov
V P
VP
Korpela
T
T
D016207:Cytokines / Q000648:ultrastructure*; D016179:Granulocyte Colony-Stimulating Factor / Q000648:ultrastructure; D013006:Growth Hormone / Q000737:chemistry; D016899:Interferon-beta / Q000648:ultrastructure; D007371:Interferon-gamma / Q000648:ultrastructure; D007376:Interleukin-2 / Q000737:chemistry; D015848:Interleukin-5 / Q000737:chemistry; D016173:Macrophage Colony-Stimulating Factor / Q000648:ultrastructure; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
D016207:Cytokines; D007376:Interleukin-2; D015848:Interleukin-5; D016179:Granulocyte Colony-Stimulating Factor; D016899:Interferon-beta; D016173:Macrophage Colony-Stimulating Factor; D007371:Interferon-gamma; D013006:Growth Hormone