title: Histocytochemistry of glycoconjugates in nasal inverted papilloma.
abstract: In order to investigate the changes in cellular distribution of the glycocalyces in nasal inverted papilloma, formalin-fixed, paraffin-embedded biopsy specimens of inverted papilloma were analyzed by the avidin-biotin-peroxidase complex technique for the demonstration of peanut agglutinin (PNA) receptors, concanavalin A (Canavalia ensiformis agglutinin; ConA) receptors, carcinoembryonic antigen (CEA), and keratin, and compared with normal nasal mucosa, nasal polyps, and papillary adenocarcinoma. The inverted papillomas were positive for PNA and CEA, to the same degree as papillary adenocarcinoma. Their PNA binding was related to the degree of dysplasia. The ConA reaction was intermediate between that of normal mucosa and adenocarcinoma. The results suggest that the alteration of cellular glycoprotein structure in inverted papilloma is associated with its biologic characterization.
authors.affiliation: Department of Otolaryngology, Changhai Hospital, Shanghai, People's Republic of China.
authors.forename: H
authors.initials: H
authors.lastname: Huang
authors.forename: D
authors.initials: D
authors.lastname: Jing
authors.forename: Z
authors.initials: Z
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Zhou
authors.forename: D
authors.initials: D
authors.lastname: Ma
mesh_terms: D000328:Adult; D010367:Arachis; D002272:Carcinoembryonic Antigen; D003208:Concanavalin A; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000276:immunology; D037102:Lectins; D008297:Male; D008562:Membrane Glycoproteins / Q000378:metabolism*; D008875:Middle Aged; D009669:Nose Neoplasms / Q000378:metabolism*; D018308:Papilloma, Inverted / Q000378:metabolism*; D019887:Peanut Agglutinin; D037121:Plant Lectins
chemical_list: D002272:Carcinoembryonic Antigen; D037102:Lectins; D008562:Membrane Glycoproteins; D019887:Peanut Agglutinin; D037121:Plant Lectins; D003208:Concanavalin A; D007633:Keratins