title: Sequential resection of residual abdominal and thoracic masses after chemotherapy for metastatic non-seminomatous germ cell tumours.
abstract: Thirty-eight patients with advanced non-seminomatous germ cell tumours (NSGCTs) underwent multiple surgical interventions (two in 33 patients, three in four patients, four in one patient) after cisplatin-based chemotherapy. All patients had normal serum tumour markers but persistent radiographic masses. The larger mass was routinely resected first. Fifteen patients (39%) had dissimilar histological findings at sequential surgical procedures, 12 of whom demonstrated less favourable pathological features during the first operation and three at the second. Patients who underwent both retroperitoneal lymph node dissection (RPLND) and lung resection showed less favourable histological features in the retroperitoneum in nine cases and in the lung in three cases. Eight of 16 patients (50%) without mature teratoma in their primary tumours showed complete necrosis/fibrosis at all surgical interventions, whereas all patients whose primary tumour was classified as malignant teratoma intermediate demonstrated mature teratoma at least at one anatomical site. As histology of post-chemotherapy residual masses cannot be extrapolated from one anatomical site to another, patients usually are properly managed by excision of all residual masses. In particular, in patients with necrosis/fibrosis at lung resection omission of RPLND is not advised.
authors.affiliation: Department of Internal Medicine III, Klinikum Grosshadern, University of Munich, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Gerl
authors.forename: C
authors.initials: C
authors.lastname: Clemm
authors.forename: N
authors.initials: N
authors.lastname: Schmeller
authors.forename: H
authors.initials: H
authors.lastname: Dienemann
authors.forename: M
authors.initials: M
authors.lastname: Weiss
authors.forename: M
authors.initials: M
authors.lastname: Kriegmair
authors.forename: U
authors.initials: U
authors.lastname: Löhrs
authors.forename: W
authors.initials: W
authors.lastname: Wilmanns
mesh_terms: D000008:Abdominal Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005355:Fibrosis; D018237:Germinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D006801:Humans; D008297:Male; D009336:Necrosis; D018239:Seminoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D013724:Teratoma / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*; D013899:Thoracic Neoplasms / Q000188:drug therapy* / Q000556:secondary / Q000601:surgery*
chemical_list: D001761:Bleomycin; D005047:Etoposide; D003520:Cyclophosphamide; D002945:Cisplatin