Superfluous neurotransmitters?
In recent years, studies have suggested that the complexity of eukaryotic gene regulation, with its recurring and interacting motifs of cis and trans-acting regulatory elements, might result in superfluous gene expression. This conclusion is supported by a variety of experimental results that suggest that non-adaptive gene expression might be common. However, with few exceptions, the practical ramifications of unnecessary gene expression for cell biologists have not been addressed directly; this is particularly true for peptidergic neurophysiology, a field that might be plagued more than most with the consequences of this phenomenon. In this article, Chauncey W. Bowers discusses the superfluous expression of neuropeptides in the nervous system in the context of gene regulation extrapolated from studies in Drosophila.
Bowers
C W
CW
Division of Neurosciences, Beckman Research Institute, City of Hope, Duarte, CA 91010.
D000818:Animals; D005786:Gene Expression Regulation / Q000502:physiology*; D006801:Humans; D009479:Neuropeptides / Q000235:genetics / Q000502:physiology; D018377:Neurotransmitter Agents / Q000235:genetics / Q000502:physiology*
D009479:Neuropeptides; D018377:Neurotransmitter Agents