Satellite oligodendrocytes and myelin are displaced in the cortex of the reeler mouse.
The spatial distribution of satellite (perineuronal) oligodendrocytes and myelin was studied in the cortices of normal and reeler mice. In normal mice, satellite oligodendrocytes were concentrated in the inner third of the cortex. In reeler mice, satellite oligodendrocytes were present beneath the pial surface and distributed throughout the width of the cortex. In reeler mice, but not normal mice, myelin was present in patches beneath the pia and distributed throughout the width of the cortex. The abnormal position of satellite oligodendrocytes and myelin coincides with the displacement of neurons and axons in the cortex of reeler mice. These studies indicate that the distribution of cortical oligodendrocytes is influenced by neuronal/axonal position.
LeVine
S M
SM
Department of Physiology, University of Kansas Medical Center, Kansas City 66160.
Torres
M V
MV
D000375:Aging / Q000502:physiology; D000818:Animals; D001369:Axons / Q000648:ultrastructure; D002540:Cerebral Cortex / Q000254:growth & development / Q000648:ultrastructure*; D006651:Histocytochemistry; D051379:Mice; D008818:Mice, Neurologic Mutants; D009186:Myelin Sheath / Q000648:ultrastructure*; D009474:Neurons / Q000648:ultrastructure; D009836:Oligodendroglia / Q000648:ultrastructure*; D016612:Paraffin Embedding; D013194:Staining and Labeling