Molecular mimicry between GQ1b ganglioside and lipopolysaccharides of Campylobacter jejuni isolated from patients with Fisher's syndrome.
We isolated Campylobacter jejuni from 2 patients with Fisher's syndrome subsequent to enteritis. Crude lipopolysaccharide fractions were extracted from the bacteria and separated by thin-layer chromatography. Monoclonal antibodies to GQ1b ganglioside (GMR13 and 7F5) reacted with both lipopolysaccharide fractions, indicating that the lipopolysaccharides bear the GQ1b epitope. This is the first report of molecular mimicry between neural tissue components and the antecedent infectious agents of Fisher's syndrome.
Yuki
N
N
Department of Neurology, Tokyo Medical and Dental University, Japan.
Taki
T
T
Takahashi
M
M
Saito
K
K
Yoshino
H
H
Tai
T
T
Handa
S
S
Miyatake
T
T
D000911:Antibodies, Monoclonal; D002169:Campylobacter Infections / Q000276:immunology*; D016123:Campylobacter jejuni / Q000276:immunology* / Q000302:isolation & purification; D002524:Cerebellar Ataxia / Q000276:immunology* / Q000382:microbiology; D002855:Chromatography, Thin Layer; D000939:Epitopes; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D008070:Lipopolysaccharides / Q000276:immunology*; D008297:Male; D018716:Molecular Mimicry; D009886:Ophthalmoplegia / Q000276:immunology / Q000382:microbiology; D013577:Syndrome
D000911:Antibodies, Monoclonal; D000939:Epitopes; D005732:Gangliosides; D008070:Lipopolysaccharides; C039129:GQ1b ganglioside