Genetic analyses of cell-matrix interactions in development.
The extracellular matrix and its cell surface receptors are thought to be important in development. Recent applications of targeted mutagenesis in mice have begun to test hypotheses based on in vitro data and patterns of expression. 'Knockout' mutations of matrix molecules and integrins reveal complexities arising from multiple receptors and ligands.
Hynes
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Howard Hughes Medical Institute and Center for Cancer Research, Massachusetts Institute of Technology, Cambridge 02139.
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology*; D002450:Cell Communication; D004627:Embryonic Induction / Q000235:genetics*; D016326:Extracellular Matrix Proteins / Q000235:genetics / Q000502:physiology*; D005353:Fibronectins / Q000235:genetics / Q000502:physiology; D018390:Gene Targeting; D016023:Integrins / Q000235:genetics / Q000502:physiology; D051379:Mice; D018345:Mice, Knockout; D009024:Morphogenesis / Q000235:genetics; D016297:Mutagenesis, Site-Directed; D011956:Receptors, Cell Surface / Q000502:physiology*; D017469:Receptors, Fibronectin / Q000235:genetics / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D013234:Stem Cells
D015815:Cell Adhesion Molecules; D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D016023:Integrins; D011956:Receptors, Cell Surface; D017469:Receptors, Fibronectin