title: [Effect of excessive fluoride intake on mental work capacity of children and a preliminary study of its mechanism].
abstract: We made an investigation in 157 children, aged 12-13, born and grew up in a coal burning pattern endemic fluorosis area and an experiment on excessive fluoride intake in rat. The results showed: (1) Excessive fluoride intake since early childhood would reduce mental work capacity (MWC) and hair zinc content: (2) The effect on zinc metabolism was a mechanism of influence on MWC by excessive fluoride intake; (3) Excessive fluoride intake decreased 5-hydroxy indole acetic acid and increased norepinephrine in rat brain; whether this is also a mechanism of the influence on MWC awaits confirmation.
authors.forename: Y
authors.initials: Y
authors.lastname: Li
authors.forename: X
authors.initials: X
authors.lastname: Li
authors.forename: S
authors.initials: S
authors.lastname: Wei
mesh_terms: D000293:Adolescent; D000818:Animals; D001921:Brain / Q000378:metabolism*; D002648:Child; D005458:Fluoride Poisoning / Q000378:metabolism / Q000523:psychology*; D006197:Hair / Q000378:metabolism; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008606:Mental Processes; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000378:metabolism
chemical_list: D006897:Hydroxyindoleacetic Acid; D015032:Zinc; D009638:Norepinephrine