title: Combination chemotherapy with epirubicin, cisplatin and 5-fluorouracil for the palliation of advanced gastric and oesophageal adenocarcinoma.
abstract: The palliative efficacy of laser therapy with combination chemotherapy (cisplatin, epirubicin and continuous infusion of 5-fluorouracil) was assessed in 34 patients with inoperable gastro-oesophageal cancer. Comparison was made with a group of 30 patients treated previously by laser alone. Twenty patients responded to chemotherapy. There was a significant improvement in dysphagia, as measured by a decreased laser requirement to maintain satisfactory swallowing. In this non-randomized prospective phase II trial, palliation was attained and some responses were long-lasting (median duration of response 8.7 (range 2.3 to more than 29.2) months).
authors.affiliation: Department of Medical Oncology, United Medical School of Guy's Hospital, London, UK.
authors.forename: M S
authors.initials: MS
authors.lastname: Highley
authors.forename: F X
authors.initials: FX
authors.lastname: Parnis
authors.forename: G A
authors.initials: GA
authors.lastname: Trotter
authors.forename: S J
authors.initials: SJ
authors.lastname: Houston
authors.forename: R T
authors.initials: RT
authors.lastname: Penson
authors.forename: P G
authors.initials: PG
authors.lastname: Harper
authors.forename: R C
authors.initials: RC
authors.lastname: Mason
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D015251:Epirubicin / Q000008:administration & dosage; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000401:mortality; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods*; D011379:Prognosis; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000401:mortality; D016019:Survival Analysis
chemical_list: D015251:Epirubicin; D002945:Cisplatin; D005472:Fluorouracil