Trisomy 2, trisomy 20, and del(17p) as sole chromosomal abnormalities in three cases of hepatoblastoma.
Short-term cultures of three hepatoblastomas were analyzed cytogenetically. Trisomy 2, trisomy 20, and a deletion of 17p were found as the sole abnormalities, yielding the karyotypes 47,XY, + 2; 47,XX, + 20; and 46,XX,del(17)(p12)/46,XX. This is the first reported case of deletion of 17p as the sole chromosomal abnormality in a hepatoblastoma and the first reported case of trisomy 20 without double minute chromosomes as a sole chromosomal abnormality in hepatoblastoma.
Tonk
V S
VS
Department of Pathology, University of Texas Southwestern Medical Center, Dallas 75235-9072.
Wilson
K S
KS
Timmons
C F
CF
Schneider
N R
NR
D002872:Chromosome Deletion; D002886:Chromosomes, Human, Pair 17; D002889:Chromosomes, Human, Pair 2; D002890:Chromosomes, Human, Pair 20; D005260:Female; D018197:Hepatoblastoma / Q000235:genetics*; D006801:Humans; D007223:Infant; D007621:Karyotyping; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D014314:Trisomy / Q000235:genetics*