[Changes in hemodynamic parameters and temperature regimen in the system mother-placenta-fetus as affected by various drugs].
In the chronic experiments at the end of pregnancy the effects of the infusion to mother of some drugs (trental, reopolyglucin and their combination) on the female of a rabbit and its fetuses normally developed and growth retarded were studied. It was found that changes in the intensity of maternal-placental blood flow, induced by the infusion of drugs to mother lead to the changes of gradient between temperature of fetus and mother, which reflect intensity of feto-placental blood flow and consequently the intensity of fetal heat loss. The possible unfavourable influence of these drugs on fetus temperature regimen and consequently on its metabolic processes under the treatment of placental insufficient and growth retardation have been taken into consideration.
Kavraĭskaia
I A
IA
Nazarova
L A
LA
D000818:Animals; D001833:Body Temperature Regulation / Q000187:drug effects*; D003911:Dextrans / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008431:Maternal-Fetal Exchange; D010431:Pentoxifylline / Q000494:pharmacology*; D010920:Placenta / Q000098:blood supply / Q000187:drug effects*; D011247:Pregnancy; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects
D003911:Dextrans; D010431:Pentoxifylline