title: A note on modeling mechano-chemical transduction with an application to a skin receptor.
abstract: Strain-sensitive (also called stretch-sensitive) ionic channels are thought to be present in various mechanoreceptors. The gating of these channels is precipitated by mechanical strains, as opposed to the usual activation processes of changes in membrane potential or other ligands. Below we present a class of models for the strain-activated mechanism, compare our approach to one of Sachs and Lecar (1991) and apply the gating mechanism to a model of a specific mechanoreceptor, namely a Pacinian corpuscle neurite model. The simulation experiment suggests the activation energy of the channel depends linearly, rather than nonlinearly, on the (hoop) strain in the receptor membrane.
authors.affiliation: Department of Mathematics, SUNY at Buffalo 14214.
authors.forename: J
authors.initials: J
authors.lastname: Bell
authors.forename: M H
authors.initials: MH
authors.lastname: Holmes
mesh_terms: D000818:Animals; D006801:Humans; D015640:Ion Channel Gating; D007473:Ion Channels / Q000502:physiology*; D008433:Mathematics; D008465:Mechanoreceptors / Q000502:physiology*; D008959:Models, Neurological; D015398:Signal Transduction; D012867:Skin / Q000294:innervation*
chemical_list: D007473:Ion Channels