The proto-oncogene of v-eyk (v-ryk) is a novel receptor-type protein tyrosine kinase with extracellular Ig/GN-III domains.
v-ryk is the oncogene in the avian acute oncogenic retrovirus RPL30, its cellular counterpart, c-ryk, is described in this report. To avoid the confusion caused by another gene with the same name, we renamed v-ryk to be v-eyk, thereby changing the proto-oncogene's name to c-eyk. c-eyk is expressed highly in chicken spleen and moderately in many other tissues including embryonic tissues. Its cDNA is 3061 base pairs encoding a receptor-type protein tyrosine kinase (PTK) of 974 amino acids. Compared to c-Eyk, v-Eyk is a truncated PTK lacking the extracellular and transmembrane regions of c-Eyk in addition to two amino acid changes. c-Eyk has two C2-type Ig domains and two FN-III domains in its extracellular region, forming a new subfamily of receptor-type PTK together with UFO/Axl/Ark. As suggested by Ig/Fn-III domains in many cell adhesion molecules, this subfamily of PTK may mediate cell-cell interaction.
Jia
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Rockefeller University, New York, New York 10021-6399.
Hanafusa
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D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D002462:Cell Membrane / Q000201:enzymology; D002642:Chick Embryo; D002645:Chickens; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics; D006801:Humans; D008565:Membrane Proteins / Q000737:chemistry; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D015513:Oncogene Proteins; D015514:Oncogene Proteins, Fusion / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D009928:Organ Specificity; D011061:Poly A / Q000302:isolation & purification / Q000378:metabolism; D017433:Protein Structure, Secondary; D000090063:Proto-Oncogene Mas; D011519:Proto-Oncogenes; D012313:RNA / Q000302:isolation & purification / Q000378:metabolism; D012333:RNA, Messenger / Q000302:isolation & purification / Q000378:metabolism; D020794:Receptor Protein-Tyrosine Kinases / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D012190:Retroviridae / Q000235:genetics; D017386:Sequence Homology, Amino Acid; D013154:Spleen / Q000378:metabolism; D014764:Viral Proteins
C000715470:MAS1 protein, human; D008565:Membrane Proteins; D015513:Oncogene Proteins; D015514:Oncogene Proteins, Fusion; D000090063:Proto-Oncogene Mas; D012333:RNA, Messenger; D014764:Viral Proteins; C076739:v-ryk protein, avian retrovirus; D011061:Poly A; D012313:RNA; D004247:DNA; D020794:Receptor Protein-Tyrosine Kinases