[The immunoadjuvant properties of hydroxyapatite with ultrahigh dispersity].
Chemically pure hydroxyapatite (HA) with particles less than 140 microns, less than 60 microns, and 0.01 to 0.03 microns was studied. The immunoadjuvant properties were assessed from the count of IgM-secreting cells and titer of IgG antibodies. Mice were immunized with Salmonella Vi antigen, using mixtures of the antigen with HA with different size of particles. Preparations with particles less than 60 microns and 0.01 to 0.03 micron had a reliable immunoadjuvant effect, whereas HA with particles of up to 140 microns in size did not show such an effect; these data are in line with those published elsewhere about HA as a surfactant. At the same time, our findings give grounds to speak about new prospects of HA use as a carrier of immunocorrective properties.
Zuev
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Novikov
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Pankratov
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D000276:Adjuvants, Immunologic / Q000737:chemistry / Q000494:pharmacology*; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D001672:Biocompatible Materials / Q000737:chemistry / Q000494:pharmacology*; D017886:Durapatite / Q000737:chemistry / Q000494:pharmacology*; D007111:Immunity, Cellular / Q000187:drug effects; D007114:Immunization; D007074:Immunoglobulin G / Q000097:blood / Q000187:drug effects; D007075:Immunoglobulin M / Q000097:blood / Q000187:drug effects; D051379:Mice; D010316:Particle Size; D011135:Polysaccharides, Bacterial; D012485:Salmonella typhi / Q000276:immunology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000942:Antigens, Bacterial; D001672:Biocompatible Materials; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D011135:Polysaccharides, Bacterial; D017886:Durapatite