Human d-amphetamine drug discrimination: methamphetamine and hydromorphone.
Standard measures of subjective and discriminative effects of drugs were compared in 5 human volunteers. Subjects responded on a second-order color-tracking procedure, where 30 mg of d-amphetamine served as a discriminative stimulus for one response and its absence as the discriminative stimulus for another response. Self-reported subjective effects were assessed concurrently using the single-dose questionnaire, subscales of the Addiction Research Center Inventory, and several analogue rating scales. On different days following discrimination acquisition, varying doses of d-amphetamine, methamphetamine, and hydromorphone were administered. In these test sessions, either response was reinforced. Methamphetamine and d-amphetamine occasioned dose-related increases in d-amphetamine appropriate responding; hydromorphone did not. Methamphetamine and d-amphetamine occasioned dose-related increases in reports of the drug received being most like "speed"; hydromorphone occasioned dose-related increases in reports of the drug received being most like "dope." All three drugs occasioned dose-related increases in reports of drug liking, and increases in the morphine-benzedrine group, amphetamine, and benzedrine group scales of the Addiction Research Center Inventory. This experiment demonstrated that although explicit discriminative control of behavior by a drug may covary with drug identification, it does not necessarily covary with other self-reported subjective effects. Thus, the complementary nature of the data provided by drug discrimination and standard subjective-effects measures provides quantitative and qualitative data useful in studying both relatively novel compounds and the behavioral biology of psychoactive drugs in general.
Lamb
R J
RJ
Hahnemann University, Philadelphia, Pennsylvania 19102-1192.
Henningfield
J E
JE
D000328:Adult; D003913:Dextroamphetamine / Q000008:administration & dosage*; D004193:Discrimination Learning; D004305:Dose-Response Relationship, Drug; D006801:Humans; D004091:Hydromorphone / Q000008:administration & dosage*; D008297:Male; D008694:Methamphetamine / Q000008:administration & dosage*; D019966:Substance-Related Disorders; D011795:Surveys and Questionnaires
D008694:Methamphetamine; D004091:Hydromorphone; D003913:Dextroamphetamine