[The biological properties of two CD71 McAbs].
Two monoclonal antibodies (McAbs), HI160 and HI166, recognize different epitopes of the CD71 antigen. Their biological properties have been studied, and the results demonstrated that both had down-regulation effects. HI160 McAb not only inhibited the activation and proliferation of T and B lymphocytes but also the growth of CFU-GM. HI166 McAb only inhibited the activation and proliferation of T lymphocytes. The differences in the biological properties of the two CD71 McAbs might be due to the different epitopes recognized by them. The application value of these McAbs is discussed.
Yang
C
C
Institute of Hematology, CAMS and PUMC, Tianjin.
Shen
D
D
Yang
X
X
D000911:Antibodies, Monoclonal / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D003114:Colony-Forming Units Assay; D000939:Epitopes / Q000276:immunology; D006801:Humans; D008213:Lymphocyte Activation; D011990:Receptors, Transferrin; D013601:T-Lymphocytes / Q000276:immunology
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; C068126:CD71 antigen; D000939:Epitopes; D011990:Receptors, Transferrin