title: Variability of left atrial bloodflow predicts intolerance of ventricular demand pacing and may cause pacemaker syndrome.
abstract: Variability of left and right atrial and left ventricular bloodflow was studied using transthoracic and transesophageal Doppler echocardiography and related to pacemaker mode preference during everyday activity. Bloodflow variability was less at all sites during dual chamber pacing compared to single chamber pacing. However, in patients suffering from pacemaker syndrome and who prefer DDDR pacing, significantly increased variability of left atrial antegrade (but not retrograde) bloodflow during VVIR pacing compared to DDDR pacing was noted, which was not evident in patients tolerating VVIR mode pacing. This effect was not detected at any other site and suggests that adverse left atrial hemodynamics may result in intolerance to VVI/R mode pacing and might cause pacemaker syndrome.
authors.affiliation: Department of Cardiology, Guy's Hospital, London, United Kingdom.
authors.forename: N
authors.initials: N
authors.lastname: Sulke
authors.forename: J
authors.initials: J
authors.lastname: Chambers
authors.forename: E
authors.initials: E
authors.lastname: Sowton
mesh_terms: D000328:Adult; D000368:Aged; D016279:Atrial Function, Left; D001783:Blood Flow Velocity; D002304:Cardiac Pacing, Artificial / Q000009:adverse effects / Q000379:methods*; D004311:Double-Blind Method; D004452:Echocardiography; D017548:Echocardiography, Transesophageal; D005260:Female; D006325:Heart Atria / Q000000981:diagnostic imaging*; D006327:Heart Block / Q000000981:diagnostic imaging / Q000503:physiopathology / Q000628:therapy; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D010138:Pacemaker, Artificial; D017060:Patient Satisfaction; D011667:Pulmonary Veins / Q000503:physiopathology; D013577:Syndrome; D014683:Vena Cava, Superior / Q000503:physiopathology