[Drug-induced organic mood disorders].
Firstly, we reviewed the drugs (ex, corticosteroid, interferon) which were thought to be related to organic mood disorders in the literature, and discussed a number of problems with assessment of drug-induced mental disorders. Next, we investigated 1) the antidepressant-induced switch rate from depression to mania and 2) the latency from administration to manic onset in three groups (Major depression: single episode, Major depression: recurrent, Bipolar disorder: depressed). Our data showed, 1) the switch rate was 17.2, 14.3, 32.0% and 2) the latency to onset was 69.9, 65.9, 37.1 days, respectively. The latency to onset showed no significant difference in three groups. (ANOVA, p < 0.05) Clomipramine, amitriptyline, imipramine, and dosulepin had the higher switch rate above 10%.
Sasaki
I
I
Department of Neuropsychiatry, Oita Medical University.
Fujii
I
I
D000928:Antidepressive Agents / Q000009:adverse effects; D000959:Antihypertensive Agents / Q000009:adverse effects*; D006801:Humans; D007372:Interferons / Q000009:adverse effects; D013256:Steroids / Q000009:adverse effects; D019966:Substance-Related Disorders
D000928:Antidepressive Agents; D000959:Antihypertensive Agents; D013256:Steroids; D007372:Interferons