Tracing the spread of fibronectin type III domains in bacterial glycohydrolases.
The evolutionary spread of 22 fibronectin type III (Fn3) sequences among a dozen bacterial enzymes has been traced by searching databases with the non-Fn3 parts of the enzyme sequences. Numerous homologues were found that lacked the Fn3 domains. In each case the related sequences were aligned, phylogenetic trees were constructed, and the occurrences of Fn3 units on the trees were noted. Comparison with phylogenetic trees prepared from the Fn3 segments themselves allowed inferences to be made about when the Fn3 units were shuffled into their present positions.
Little
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Center for Molecular Genetics, University of California, San Diego, La Jolla 92093-0634.
Bork
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Doolittle
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D000595:Amino Acid Sequence; D000681:Amylases / Q000235:genetics; D001419:Bacteria / Q000235:genetics; D001482:Base Composition; D005075:Biological Evolution; D002480:Cellulase / Q000235:genetics; D002688:Chitinases / Q000235:genetics; D005353:Fibronectins / Q000235:genetics*; D006026:Glycoside Hydrolases / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D016415:Sequence Alignment
D005353:Fibronectins; D000681:Amylases; D006026:Glycoside Hydrolases; D002688:Chitinases; D002480:Cellulase; C065616:exo-poly-alpha-galacturonosidase