title: Cholecystokinin is not a major regulator in the digestive system in the chicken.
abstract: To find out whether physiological concentrations of cholecystokinin (CCK), a gastrointestinal hormone in mammals, are also active in chickens, the pancreatic amylase secretory response to CCK-8 was investigated in vitro. Rat pancreatic acini responded to the physiological concentration of CCK-8, but in chickens amylase release was induced at a concentration of CCK-8 1000 times higher than that observed in rats. In another experiment, biliary flow was tested with several doses of CCK-8. The bile flow was stimulated in a dose-dependent fashion, but a significant enhancement was not obtained at a concentration of 0.5 micrograms CCK-8/kg body weight, which was considerably higher than physiological ones. It is concluded that endogenous CCK does not have an important role in the digestive system in the chicken.
authors.affiliation: Laboratory of Animal Nutrition, School of Agriculture, Nagoya University, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Furuse
authors.forename: Y H
authors.initials: YH
authors.lastname: Choi
authors.forename: J
authors.initials: J
authors.lastname: Okumura
mesh_terms: D000681:Amylases / Q000378:metabolism; D000818:Animals; D002645:Chickens / Q000502:physiology*; D002766:Cholecystokinin / Q000502:physiology*; D004063:Digestion / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000201:enzymology; D051381:Rats; D012844:Sincalide / Q000008:administration & dosage / Q000494:pharmacology
chemical_list: D002766:Cholecystokinin; D000681:Amylases; D012844:Sincalide