Role of granulocyte colony-stimulating factor in the immune response to acute bacterial infection in the nonneutropenic host: an overview.
Granulocyte colony-stimulating factor (G-CSF) regulates the production and potentiates the function of neutrophils. Studies of animals and patients have shown that levels of G-CSF increase in response to certain types of acute bacterial infection; for example, levels of this factor increase in the lungs and in serum during pneumonia. Investigations of several nonneutropenic animal models of severe bacterial infection have indicated that exogenous recombinant G-CSF--either alone or in combination with antibiotics--can significantly enhance host defenses and improve rates of survival. Trials of recombinant G-CSF for the prevention or treatment of serious infection in clinical settings have recently been initiated.
Nelson
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Section of Pulmonary/Critical Care Medicine, Louisiana State University Medical Center, New Orleans.
D000208:Acute Disease; D000818:Animals; D001424:Bacterial Infections / Q000276:immunology*; D002986:Clinical Trials as Topic; D016179:Granulocyte Colony-Stimulating Factor / Q000276:immunology*; D006801:Humans; D051379:Mice; D009504:Neutrophils / Q000276:immunology*; D011014:Pneumonia / Q000276:immunology*; D051381:Rats
D016179:Granulocyte Colony-Stimulating Factor