title: Inhibition of nitric oxide synthase by antineoplastic anthracyclines.
abstract: Nitric oxide synthase, the enzyme responsible for the synthesis of nitric oxide and citrulline from arginine, was potently inhibited by the anthracycline antibiotics doxorubicin (Ki = 24 microM) and aclarubicin (Ki = 50 microM). These drugs were non-competitive inhibitors with respect to arginine. This action on nitric oxide synthase may explain some of the cardiovascular and cytotoxic actions of these chemotherapeutic drugs.
authors.affiliation: Department of Psychiatry, University of British Columbia, Vancouver, Canada.
authors.forename: D
authors.initials: D
authors.lastname: Luo
authors.forename: S R
authors.initials: SR
authors.lastname: Vincent
mesh_terms: D015250:Aclarubicin / Q000494:pharmacology*; D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001120:Arginine / Q000378:metabolism; D001923:Brain Chemistry; D002956:Citrulline / Q000378:metabolism; D004317:Doxorubicin / Q000494:pharmacology*; D008297:Male; D019001:Nitric Oxide Synthase; D051381:Rats; D017208:Rats, Wistar
chemical_list: D002956:Citrulline; D015250:Aclarubicin; D004317:Doxorubicin; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases