Element variations in pregnant and nonpregnant female rats orally intoxicated by aluminum lactate.
Pregnant or nonpregnant female rats were orally intoxicated by aluminum lactate (400 mg Al/kg/d) from d 0-19 of gestation to determine the treatment's influence on element variations in the females and their fetuses. The aluminum levels of plasma, liver, spleen, and kidneys were significantly higher in treated pregnant rats than non-pregnant female rats. Differences of P, Ca, Cu, Zn, or Mg levels were observed among the four groups of female rats in the tissues and plasma. The aluminum content of the 20-d-old fetuses did not significantly differ between the treated and control groups. On the contrary, calcium and magnesium levels in the whole fetuses from treated or nontreated dams are significantly different.
Muller
G
G
Centre des Sciences de l'Environnement, Toxicologie-Neurotoxicologie, Université de Metz, France.
Burnel
D
D
Gery
A
A
Lehr
P R
PR
D000284:Administration, Oral; D000535:Aluminum / Q000097:blood / Q000378:metabolism*; D000818:Animals; D005260:Female; D005333:Fetus / Q000378:metabolism*; D005865:Gestational Age; D007668:Kidney / Q000378:metabolism; D007773:Lactates / Q000008:administration & dosage / Q000633:toxicity*; D019344:Lactic Acid; D008099:Liver / Q000378:metabolism; D008297:Male; D011247:Pregnancy; D011256:Pregnancy Outcome; D011270:Pregnancy, Animal / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000378:metabolism; D014131:Trace Elements / Q000097:blood / Q000378:metabolism
D007773:Lactates; D014131:Trace Elements; D019344:Lactic Acid; D000535:Aluminum