title: First use of G-CSF in chlorpromazine-induced agranulocytosis: a report of two cases.
abstract: Chlorpromazine-induced agranulocytosis is an uncommon disorder associated with a high frequency of fatality. We describe two patients with chlorpromazine-induced granulocytosis in whom granulocyte colony stimulating factor (G-CSF) administration enhanced the speed of neutrophil recovery. No toxicity was noted with G-CSF and both patients made a successful recovery. We propose there is a role for such cytokine therapy in patients with life-threatening agranulocytosis in order to speed the recovery of neutrophils.
authors.affiliation: Burnley General Hospital, UK.
authors.forename: J R
authors.initials: JR
authors.lastname: Kendra
authors.forename: F P
authors.initials: FP
authors.lastname: Rugman
authors.forename: T A
authors.initials: TA
authors.lastname: Flaherty
authors.forename: A
authors.initials: A
authors.lastname: Myers
authors.forename: N
authors.initials: N
authors.lastname: Horsfield
authors.forename: A
authors.initials: A
authors.lastname: Barton
authors.forename: L
authors.initials: L
authors.lastname: Russell
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000139:chemically induced / Q000188:drug therapy*; D002746:Chlorpromazine / Q000009:adverse effects*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008875:Middle Aged; D009504:Neutrophils / Q000187:drug effects
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D002746:Chlorpromazine