Mutagenic risk in psoriatic patients before and after 8-methoxypsoralen and long-wave ultraviolet radiation.
Sister-chromatid exchange (SCE) analysis was carried out in different age groups prior to and after therapy with 8-Methoxypsoralen (8-MOP) followed by exposure of the patient to long-wave UV-A (PUVA) and compared to control. The SCE frequencies were increased significantly in PUVA-treated patients as compared to their pre-treatment SCE levels and to controls. A significant increase in SCEs was found in smoking PUVA-treated patients as compared to non-smoking PUVA-treated patients. This study indicates a detectable chromosome-damaging effect of PUVA therapy on its human users.
Sardaş
S
S
Gazi University, Faculty of Pharmacy, Toxicology Department, Ankara, Turkey.
Karahalil
B
B
Karakaya
A E
AE
Saşmaz
R
R
D000293:Adolescent; D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D002648:Child; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016296:Mutagenesis; D011701:PUVA Therapy / Q000009:adverse effects*; D011565:Psoriasis / Q000188:drug therapy*; D012854:Sister Chromatid Exchange; D012907:Smoking / Q000009:adverse effects