Enhancement of cytogenetic damage and of antineoplastic effect in lymphoid L1210 leukemia cells treated with prostaglandin E2 and cyclophosphamide in vivo.
An enhanced frequency of sister-chromatid exchanges (SCEs) and increased cell division delays induced by cyclophosphamide (CP) were observed when lymphoid L1210 leukemia cells were post-treated in vivo with prostaglandin E2 (PGE2). CP gave a slight, non-significant increase in survival while PGE2 gave a slight, non-significant decrease in survival. However, PGE2 in combination with CP was found to have a non-significant potentiating effect on survival in comparison with mice treated with CP alone. In mice treated with the combined CP (5 micrograms/g b.w.) plus PGE2 (2 micrograms/g b.w.) treatment, a significant (P < 0.01) enhancement of survival time in comparison with the untreated controls was observed.
Mourelatos
D
D
Department of General Biology and Genetics, Faculty of Medicine, Aristotle's University, Thessaloniki, Greece.
Mioglou
E
E
Kristi
Z
Z
Dozi-Vassiliades
J
J
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000494:pharmacology*; D015232:Dinoprostone / Q000494:pharmacology*; D004357:Drug Synergism; D007939:Leukemia L1210 / Q000188:drug therapy; D008297:Male; D051379:Mice; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D012854:Sister Chromatid Exchange; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D003520:Cyclophosphamide; D015232:Dinoprostone