Effects of lindane exposure on rainbow trout (Oncorhynchus mykiss) immunity. I. Effect of lindane on antibody-secreting cells (ASC) measured by ELISPOT assay.
Yersinia ruckeri vaccine was injected in rainbow trout 7 days after ip contamination with 10, 50, or 100 mg lindane per kilogram body weight. The antibody-secreting cells measured by ELISPOT assay were affected by the insecticide, slightly for 10 mg and strongly for higher concentrations. Consequently the antibody production in sera, measured by agglutination, was suppressed.
Dunier
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M
Laboratoire de Toxicologie Metabolique et Ecotoxicologie, INRA-ENVL, Marcy l'Etoile, France.
Siwicki
A K
AK
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000921:Antibody-Producing Cells / Q000187:drug effects*; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D007111:Immunity, Cellular / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects / Q000276:immunology; D017686:Oncorhynchus mykiss / Q000276:immunology*; D018675:Toxicity Tests; D015007:Yersinia / Q000276:immunology
D000907:Antibodies, Bacterial; D001556:Hexachlorocyclohexane