title: Lack of effect of acute acetaldehyde treatment on X chromosome segregation in Drosophila melanogaster females.
abstract: The effect of acute acetaldehyde treatments on X chromosome segregation was tested in germinal cells of Drosophila melanogaster females. The experiments were carried out using a test system where the nondisjunctional females (XXY) and only 1/4 of the expected regular progeny are viable. 24 h old virgin females were exposed for 60 min to 3, 4 and 5% acetaldehyde solutions by means of soaked tissue paper placed at the bottom of regular culture vials. After mating the females were brooded daily. Two additional experiments were performed with 0-2 h old and 4-5 day old virgin females using a 4% acetaldehyde solution. The results obtained show that acetaldehyde did not affect X chromosomal segregation in oocytes. This lack of effect could result from the highly efficient ADH-ALDH dependent detoxifying mechanism operating in Drosophila melanogaster.
authors.affiliation: Departamento de Radiobiología, Comisión Nacional de Energía Atómica, Buenos Aires, Argentina.
authors.forename: M
authors.initials: M
authors.lastname: Rey
authors.forename: A M
authors.initials: AM
authors.lastname: Palermo
authors.forename: E R
authors.initials: ER
authors.lastname: Muñoz
mesh_terms: D000079:Acetaldehyde / Q000633:toxicity*; D000426:Alcohol Dehydrogenase / Q000378:metabolism; D000818:Animals; D016009:Chi-Square Distribution; D004305:Dose-Response Relationship, Drug; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000201:enzymology / Q000235:genetics; D000431:Ethanol / Q000633:toxicity; D005260:Female; D008297:Male; D008540:Meiosis / Q000187:drug effects; D009152:Mutagenicity Tests; D009630:Nondisjunction, Genetic; D014960:X Chromosome / Q000187:drug effects*
chemical_list: D000431:Ethanol; D000426:Alcohol Dehydrogenase; D000079:Acetaldehyde