Bacteria-induced IgE-mediated histamine release: examination of patients with chronic bronchitis (CB) during acute exacerbations.
Twelve patients hospitalized with acute exacerbations of chronic bronchitis (CB) and infected in the lower respiratory tract with H. influenzae (HI) or Streptococcus pneumoniae (SP) were examined. Bacteria, isolated from the expectorate caused an IgE-mediated histamine release from the patient's own blood leukocytes, indicating that all were sensitized to their own bacteria. Sensitization was only observed in some of the patients when tested with a standard panel of HI or SP obtained from other patients, indicating the importance of using the patient relevant bacterial antigenic determinants. No sensitization was found in twelve controls. The patients showed cellular hyperreactivity to HI and SP, i.e. the releasability was higher than in the control group. The cellular hyperreactivity was not dependent on sensitization since it was also found against the non-infecting species. Both sensitization and cellular hyperreactivity may contribute to the aggravation of the disease.
Norn
S
S
Department of Pharmacology, University of Copenhagen, Panum Institute, Denmark.
Jensen
L
L
Kjaergaard
L L
LL
Permin
H
H
Skov
P S
PS
Espersen
F
F
D000368:Aged; D000369:Aged, 80 and over; D001419:Bacteria / Q000276:immunology*; D001491:Basophils / Q000187:drug effects / Q000378:metabolism; D016535:Bronchial Hyperreactivity / Q000503:physiopathology; D001991:Bronchitis / Q000276:immunology / Q000378:metabolism*; D002908:Chronic Disease; D006193:Haemophilus influenzae / Q000276:immunology; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007073:Immunoglobulin E / Q000502:physiology*; D008875:Middle Aged; D013296:Streptococcus pneumoniae / Q000276:immunology
D007073:Immunoglobulin E