Studies on antidepressant action of a new oxazolidinone derivative AS-8.
On the basis of previous laboratory studies AS-8 was suggested to possess antidepressant-like activity. Forced swim test, learned helplessness and conflict Vogel's test were performed after three prior administrations of AS-8 (24, 5 and 1 h before the test). The data have shown that AS-8 produces moderate antidepressant effect but did not induce anxiolytic-like action. Biochemical data revealed increased brain 5-HT and 5-HIAA levels following AS-8 administration. The combined treatment of rats with AS-8 (100 mg/kg) and amitriptyline (5 mg/kg) or desipramine (1.25 mg/kg) significantly stimulated active behavior in the forced swim test above the level obtained with each of the drug given separately. The present data suggest the potential antidepressant efficacy of AS-8 in conjunction with small doses of tricyclic antidepressants.
Kostowski
W
W
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Płaźnik
A
A
Bidziński
A
A
Rosnowska
E
E
Jessa
M
M
Nazar
M
M
D000639:Amitriptyline / Q000097:blood / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D003891:Desipramine / Q000097:blood / Q000494:pharmacology; D004357:Drug Synergism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008124:Locomotion / Q000187:drug effects; D008297:Male; D009025:Morpholines / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D023303:Oxazolidinones; D005082:Physical Exertion / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism
C090700:AS 8; D000928:Antidepressive Agents; D009025:Morpholines; D010080:Oxazoles; D023303:Oxazolidinones; D000639:Amitriptyline; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D003891:Desipramine