Monoclonal antibody G10 which recognises microtubule-associated protein 1x identifies growing axons of neurons microtransplanted into adult rat hippocampus.
Monoclonal antibody G10 recognises an epitope on microtubule-associated protein 1x, a developmentally regulated cytoskeletal protein expressed in immature axons of the central and peripheral nervous systems. Here we report that G10 can be used to identify the axonal projections of syngeneic embryonic (E14-E15) hippocampal cells microtransplanted by a minimally traumatic technique into intact adult host hippocampus.
Brook
G A
GA
Norman and Sadie Lee Research Centre, National Institute for Medical Research, Mill Hill, London, UK.
Woodhams
P L
PL
Shah
B
B
Raisman
G
G
D000818:Animals; D000911:Antibodies, Monoclonal; D001369:Axons / Q000648:ultrastructure*; D016380:Brain Tissue Transplantation / Q000502:physiology*; D000939:Epitopes / Q000032:analysis; D016332:Fetal Tissue Transplantation / Q000502:physiology; D006624:Hippocampus / Q000166:cytology / Q000637:transplantation*; D007150:Immunohistochemistry; D008869:Microtubule-Associated Proteins / Q000032:analysis*; D009474:Neurons / Q000166:cytology* / Q000637:transplantation*; D051381:Rats; D014185:Transplantation, Isogeneic
D000911:Antibodies, Monoclonal; D000939:Epitopes; D008869:Microtubule-Associated Proteins; C085284:microtubule-associated protein 1B