Cytogenetic monitoring of a village population potentially exposed to a low level of environmental pollutants. Phase 1:SCE analysis.
By analogy to the techniques applied for monitoring biological effects of exposure to genotoxic agents in occupational populations, we have carried out cytogenetic monitoring in a group of inhabitants of a village (Mellery, Belgium) suspected to have been exposed to a variety of toxic environmental pollutants. These pollutants probably originated from a neighboring chemical wastes site. A group of 51 environmentally exposed and 52 reference persons (including children) were examined for the frequency of sister-chromatid exchanges (SCE) in their peripheral blood lymphocytes. The technique was further refined by using a high frequency cells (HFC) analysis. Analysis of the reference subgroups showed a significant difference between non-smoking adults and children. The influence of tobacco was clear, too. In the exposed group, no significant differences could be demonstrated between either the smokers or the non-smokers or the children. Furthermore, not only were the mean frequencies of SCE higher than in the respective reference subgroups but comparison between the two groups also showed a higher number of individuals presenting a HFC level above the background in the exposed group. Surprisingly, the difference was more pronounced for the children. A follow-up of the same exposed population carried out 18 months later and after remediation of the atmospheric chemical release, the previously observed tendencies in the exposure parameter remained unmodified.
Lakhanisky
T
T
Division of Toxicology, Institute of Hygiene and Epidemiology, Brussels, Belgium.
Bazzoni
D
D
Jadot
P
P
Joris
I
I
Laurent
C
C
Ottogali
M
M
Pays
A
A
Planard
C
C
Ros
Y
Y
Vleminckx
C
C
D000328:Adult; D001530:Belgium; D002478:Cells, Cultured; D002648:Child; D004784:Environmental Monitoring / Q000379:methods*; D004785:Environmental Pollutants / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D008297:Male; D012016:Reference Values; D012854:Sister Chromatid Exchange / Q000187:drug effects*
D004785:Environmental Pollutants