Endothelium localization of ETB receptor revealed by immunohistochemistry.
The ETB receptor has been found to be predominantly expressed in the vascular endothelium of various bovine tissues by immunostaining with a highly specific antiserum that does not cross-react with ETA. The tissues examined include the lung, trachea, kidney, adrenal gland, pituitary gland, and cerebellum. The wide-spread localization of ETB in the endothelial lining suggests that there is an ETB-mediated autocrine system of endothelin, which plays an important role in regulation of the functions of endothelial cells.
Ghoneim
M A
MA
Department of Biological Sciences, Tokyo Institute of Technology, Japan.
Yamamoto
T
T
Hirose
S
S
Nagasawa
T
T
Hagiwara
H
H
D000818:Animals; D000918:Antibody Specificity; D002417:Cattle; D004730:Endothelium, Vascular / Q000033:anatomy & histology / Q000378:metabolism*; D007150:Immunohistochemistry; D017466:Receptors, Endothelin / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*
D017466:Receptors, Endothelin