title: [Regional adjuvant therapy in colorectal liver metastases: requirements for clinical therapy studies from the statistical viewpoint].
abstract: The most important methodical principles of clinical trials in oncology are presented and applied to the special field of adjuvant chemotherapy for liver metastases in colorectal cancer. The presentation is based on accepted biometrical principles in medicine and on our experience in several cancer trials. Special regard is given to the German multicenter study of the liver metastases working group in the "Deutsche Krebsgesellschaft".
authors.affiliation: Institut für Medizinische Biometrie der Philipps-Universität Marburg.
authors.forename: H H
authors.initials: HH
authors.lastname: Müller
authors.forename: H
authors.initials: H
authors.lastname: Schäfer
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage* / Q000009:adverse effects; D017024:Chemotherapy, Adjuvant; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D003131:Combined Modality Therapy; D003627:Data Interpretation, Statistical; D006801:Humans; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000556:secondary* / Q000601:surgery; D015337:Multicenter Studies as Topic; D016032:Randomized Controlled Trials as Topic / Q000706:statistics & numerical data*; D015996:Survival Rate; D016896:Treatment Outcome
chemical_list: D000970:Antineoplastic Agents