Biokinetics of iodine-131 in rat thyroid following lead and lithium supplementation.
The impact of lead as an environmental pollutant on the I-131 uptake and retention in rat thyroid was assayed alone and in combination with lithium treatment. Lead treatment significantly stimulated the 2- and 24-h uptake of I-131 in the thyroid, and the 24-h uptake showed the maximum stimulation after 3 mo of lead treatment. On the contrary, lithium supplementation reduced the uptake significantly and the maximum decrease was noticed after 2 mo of lithium administration. Further, simultaneous lead and lithium treatment resulted in more pronounced increase in the uptake of I-131 by the thyroid, which was maximum after 3 mo of combined treatment. The thyroid biological half-life of I-131 (Tbiol) was found to be increased significantly following lead and lithium treatments when given separately. Interestingly, combined lead and lithium treatment given up to 2 mo further prolonged the Tbiol of I-131, thus reflecting its increased retention.
Singh
B
B
Department of Biophysics, Panjab University, Chandigarh, India.
Dhawan
D
D
Chand
B
B
Mangal
P C
PC
D000818:Animals; D004785:Environmental Pollutants / Q000494:pharmacology*; D005260:Female; D006207:Half-Life; D007455:Iodine / Q000493:pharmacokinetics*; D007457:Iodine Radioisotopes; D007854:Lead / Q000494:pharmacology*; D008094:Lithium / Q000494:pharmacology*; D051381:Rats; D013961:Thyroid Gland / Q000187:drug effects / Q000378:metabolism*
D004785:Environmental Pollutants; D007457:Iodine Radioisotopes; D007854:Lead; D007455:Iodine; D008094:Lithium