Hyphodontal, a new antifungal inhibitor of reverse transcriptases from Hyphodontia sp. (Corticiaceae, Basidiomycetes).
In a search for inhibitors of RNA-directed DNA polymerases a new isolactarane sesquiterpenoid, hyphodontal (1), was isolated from fermentations of a Canadian Hyphodontia species. Its structure was elucidated by spectroscopic methods. Hyphodontal strongly inhibits the growth of several yeasts and is a non-competitive inhibitor of avian myeloblastosis virus (Ki 346 microM) and Moloney murine leukemia virus (Ki 112 microM) reverse transcriptases. In addition, cytotoxic and antifungal activities were observed.
Erkel
G
G
Lehrbereich Biotechnologie der Universität, Bundesrepublik Deutschland.
Anke
T
T
Velten
R
R
Gimenez
A
A
Steglich
W
W
D009189:Avian Myeloblastosis Virus / Q000201:enzymology; D001487:Basidiomycota / Q000254:growth & development*; D005285:Fermentation; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000201:enzymology; D007700:Kinetics; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D008979:Moloney murine leukemia virus / Q000201:enzymology; D009152:Mutagenicity Tests; D018894:Reverse Transcriptase Inhibitors; D012486:Salmonella typhimurium / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D015003:Yeasts / Q000201:enzymology
D018894:Reverse Transcriptase Inhibitors; D012717:Sesquiterpenes; C090582:hyphodontal; D054303:HIV Reverse Transcriptase