Gene transfer into human hematopoietic progenitor cells: a review of current clinical protocols.
Recent reviews by Clay Smith (1992) in this journal and by W. French Anderson (1990) and A. Dusty Miller (1992) have described the technologies used for gene transfer, the potential applications of the approach, and the safety issues that require consideration. This review will have a narrower focus. It will deal specifically with current and forthcoming clinical protocols for gene transfer into hemopoietic progenitor cells, because a major goal of gene therapy for malignant and nonmalignant disease is to transfer and express genes on a long-term basis in these cells or their progeny.
Brenner
M K
MK
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, TN 38101.
D000208:Acute Disease; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34; D015415:Biomarkers; D001804:Blood Transfusion, Autologous; D001853:Bone Marrow / Q000473:pathology; D016465:Bone Marrow Purging; D002985:Clinical Protocols; D018014:Gene Transfer Techniques / Q000592:standards; D015316:Genetic Therapy / Q000379:methods; D005822:Genetic Vectors; D006085:Graft Survival; D006410:Hematopoiesis; D018380:Hematopoietic Stem Cell Transplantation; D006412:Hematopoietic Stem Cells / Q000737:chemistry; D006801:Humans; D007951:Leukemia, Myeloid / Q000473:pathology; D014411:Neoplastic Stem Cells / Q000473:pathology; D016133:Polymerase Chain Reaction
D015703:Antigens, CD; D018952:Antigens, CD34; D015415:Biomarkers