Permselectivity in thin membrane nephropathy.
The glomerular permselectivity to polydisperse neutral dextrans was compared in 6 patients with thin membrane nephropathy (TMN) and 10 healthy controls. Despite having normal renal hemodynamics and minimal proteinuria, the patients with TMN had significantly increased fractional clearance of neutral molecules with Stokes radius > 42 A. Conventional theories of glomerular barrier size selectivity cannot fully explain these data since they would predict that our patients would have had nephrotic range proteinuria.
Thomas
D M
DM
Institute of Nephrology, University of Wales College of Medicine, Cardiff Royal Infirmary, Cardiff, United Kingdom.
Coles
G A
GA
Griffiths
D F
DF
Williams
J D
JD
D000328:Adult; D003911:Dextrans / Q000493:pharmacokinetics*; D005260:Female; D015433:Glomerulonephritis, Membranous / Q000503:physiopathology*; D006439:Hemodynamics; D006801:Humans; D007678:Kidney Glomerulus / Q000503:physiopathology*; D008297:Male; D008657:Metabolic Clearance Rate; D010316:Particle Size; D010539:Permeability
D003911:Dextrans