The CD19/CD21 signal transduction complex of B lymphocytes.
CD19 and CD21 are B-cell surface molecules that associate with each other and with CD81 and Leu-13 to generate a signal transduction complex that is independent of the antigen receptor. Current studies, reviewed here by Thomas Tedder, Liang-Ji Zhou and Pablo Engel, indicate an important biological role for this protein complex in the regulation of B-cell development and activation.
Tedder
T F
TF
Dept of Immunology, Duke University Medical Center, Durham, NC 27710.
Zhou
L J
LJ
Engel
P
P
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000276:immunology*; D018941:Antigens, CD19; D000943:Antigens, Differentiation / Q000096:biosynthesis / Q000276:immunology; D000944:Antigens, Differentiation, B-Lymphocyte / Q000096:biosynthesis / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D017464:Receptors, Complement 3d / Q000096:biosynthesis / Q000276:immunology*; D015398:Signal Transduction / Q000276:immunology*
D015703:Antigens, CD; D018941:Antigens, CD19; D000943:Antigens, Differentiation; D000944:Antigens, Differentiation, B-Lymphocyte; D017464:Receptors, Complement 3d; C062010:leu-13 antigen