Interferon inhibitors and/or inactivators in sera from patients with neoplasias.
Measurements of interferons, their inhibitors and/or inactivators and tumor necrosis factor-like activities in sera from patients with neoplasias were performed. Interferon activity could not be detected in 96% of the sera samples examined. In contrast, both interferon inhibitors and/or inactivators and tumor necrosis factor-like activities were found in a high proportion (25-100%) of sera from cancer patients but not in sera from normal individuals.
Tsantakis
G
G
3rd Department of Internal Medicine, NIMTS Hospital, Athens, Greece.
Schizas
N
N
Havredaki
M
M
D003602:Cytotoxicity, Immunologic; D006801:Humans; D007372:Interferons / Q000037:antagonists & inhibitors*; D009369:Neoplasms / Q000097:blood* / Q000276:immunology; D014407:Tumor Cells, Cultured / Q000187:drug effects; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D014409:Tumor Necrosis Factor-alpha; D007372:Interferons