Thyrotropin-secreting adenoma in an adolescent girl without increased serum thyrotropin-alpha.
A 13-year-old girl with poor weight gain and pubertal delay was referred for hyperthyroidism. Slightly elevated levels of circulating thyroid hormones failed to suppress circulating thyrotropin (TSH) levels. Despite appropriate thyrotropin-releasing hormone stimulation of TSH secretion, a thyrotropin-secreting pituitary adenoma was identified as the cause of inappropriate TSH secretion.
Korn
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EA
Department of Pediatrics (Endocrinology) and Internal Medicine (Endocrinology), Yale University School of Medicine, New Haven, Conn. 06520-8064.
Gaich
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G
Brines
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M
Carpenter
T O
TO
D000236:Adenoma / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D000293:Adolescent; D005260:Female; D015292:Glycoprotein Hormones, alpha Subunit / Q000097:blood*; D006801:Humans; D008279:Magnetic Resonance Imaging; D010911:Pituitary Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000601:surgery; D013972:Thyrotropin / Q000378:metabolism*; D013973:Thyrotropin-Releasing Hormone
D015292:Glycoprotein Hormones, alpha Subunit; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin