The role of stem cell factor in mobilization of peripheral blood progenitor cells: synergy with G-CSF.
The use of cytokine mobilized peripheral blood progenitor cells (PBPC) in transplantation following chemotherapy has led to enhanced engraftment. Granulocyte-colony stimulating factor (G-CSF) has been shown in a number of clinical studies to be an effective mobilizer of PBPC. Preclinical data in mice and primates have demonstrated a potential role for the use of stem cell factor (SCF) in mobilization of PBPC. In the studies presented here, low doses of SCF are shown to synergize with optimal doses of G-CSF to enhance the number and quality of PBPC compared to G-CSF alone. Phase I studies using r-metHuSCF demonstrated mast cell-related dose limiting effects. The data presented here have led to Phase I/II studies to evaluate the potential use of low doses of SCF in combination with G-CSF for mobilization of PBPC.
McNiece
I K
IK
Amgen, Inc., Thousand Oaks, California 91320-1789.
Briddell
R A
RA
Hartley
C A
CA
Andrews
R G
RG
D000818:Animals; D004357:Drug Synergism; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology*; D016298:Hematopoietic Cell Growth Factors / Q000502:physiology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000502:physiology*; D006801:Humans; D019089:Stem Cell Factor
D016298:Hematopoietic Cell Growth Factors; D019089:Stem Cell Factor; D016179:Granulocyte Colony-Stimulating Factor