Serum vitronectin receptor in alcoholic liver disease: correlation with fibronectin receptor and morphological features.
In order to clarify the significance of serum level of vitronectin receptor (VNR) in alcoholic liver disease (ALD), we have investigated the relationship with fibronectin receptor (FNR) and histological liver features in 21 ALD patients. Serum level of VNR and FNR was measured by enzyme immunoassay. Liver disease activity was scored based on levels of fibrosis and focal intralobular necrosis and degeneration. The serum level of VNR (micrograms/ml) was significantly higher in the patients with hepatic fibrosis (9.87 +/- 2.51) and liver cirrhosis (10.80 +/- 1.52) than in normal subjects (5.51 +/- 0.52, P < 0.01) and fatty liver subjects (6.58 +/- 0.58, P < 0.05). A positive correlation was found between serum levels of VNR and fibronectin receptor (FNR) (P < 0.05). A positive correlation was observed between the serum level of FNR and the degree of hepatic fibrosis or focal intralobular necrosis and degeneration, while no correlation was found between the serum level of VNR and the degree of histological features. A positive correlation was also noted between the serum level of FNR and N-terminal type III procollagen aminopeptide (PIIIP) (P < 0.001), while no correlation was observed between the serum level of VNR and PIIIP. We conclude that the serum level of VNR is increased in patients with advanced alcoholic liver disease. However, the mechanism by which serum levels of beta subunit of VNR and FNR are increased may be different.
Yamauchi
M
M
First Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Mizuhara
Y
Y
Toda
G
G
D000328:Adult; D015415:Biomarkers / Q000097:blood; D005260:Female; D005355:Fibrosis; D006801:Humans; D016023:Integrins / Q000032:analysis*; D008108:Liver Diseases, Alcoholic / Q000097:blood* / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D011347:Procollagen / Q000097:blood; D016024:Receptors, Cytoadhesin / Q000032:analysis*; D017469:Receptors, Fibronectin / Q000032:analysis; D019030:Receptors, Vitronectin
D015415:Biomarkers; D016023:Integrins; D011347:Procollagen; D016024:Receptors, Cytoadhesin; D017469:Receptors, Fibronectin; D019030:Receptors, Vitronectin