Hypoxemia and increased fetal hemoglobin synthesis.
Fetal hemoglobin (HbF) synthesis in children with congenital cyanotic heart disease was compared that in normal children. Children with hypoxemia had higher levels of hemoglobin, total HbF, and HbF synthesis. In these children there was also an inverse correlation between HbF synthesis and oxygen content, as well as between HbF synthesis and hemoglobin concentration. Thus hypoxemia increases HbF synthesis.
Bard
H
H
Neonatology Service, St. Justine's Hospital, Montreal, Quebec, Canada.
Fouron
J C
JC
Gagnon
C
C
Gagnon
J
J
D002648:Child; D002675:Child, Preschool; D003490:Cyanosis; D004921:Erythropoietin / Q000097:blood; D005319:Fetal Hemoglobin / Q000096:biosynthesis*; D006330:Heart Defects, Congenital / Q000097:blood / Q000378:metabolism*; D006801:Humans; D000860:Hypoxia / Q000378:metabolism*; D007223:Infant
D004921:Erythropoietin; D005319:Fetal Hemoglobin