title: Regional oxygen consumption persists in dyskinetic canine myocardium.
abstract: Regional myocardial O2 consumption was measured in anesthetized dogs both in baseline conditions and during intracoronary infusion of lidocaine, verapamil, sodium citrate, or 2,3-butanedione-monoxime (BDM). Despite regional hypokinesis and dyskinesis during drug infusion, regional O2 consumption was reduced only 30-40% by lidocaine, verapamil, and citrate and not at all by BDM. These results cast doubt on an important assumption of the "hibernation" theory: the protective matching of regional perfusion and contraction.
authors.affiliation: Department of Anesthesiology and Critical Care Medicine, University of Pittsburgh, Pennsylvania.
authors.forename: C W
authors.initials: CW
authors.lastname: Buffington
authors.forename: D P
authors.initials: DP
authors.lastname: Strum
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D001794:Blood Pressure; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002951:Citrates / Q000494:pharmacology; D003326:Coronary Circulation; D003931:Diacetyl / Q000031:analogs & derivatives* / Q000494:pharmacology; D004285:Dogs; D006339:Heart Rate; D007261:Infusions, Intra-Arterial; D008012:Lidocaine / Q000494:pharmacology; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000517:prevention & control*; D010101:Oxygen Consumption / Q000187:drug effects*; D014700:Verapamil / Q000494:pharmacology
chemical_list: D002121:Calcium Channel Blockers; D002951:Citrates; C004717:diacetylmonoxime; D008012:Lidocaine; D014700:Verapamil; D003931:Diacetyl