title: Risperidone in the treatment of pervasive developmental disorder.
abstract: Elevated concentrations of blood serotonin have been documented in autistic children and mentally retarded adults. Antiserotonergic pharmacotherapy has been partially effective in treating a subgroup of children with autistic disorder. Therefore, the possibility is raised that an antiserotonergic treatment may be of value to adult psychiatric patients with a history of pervasive developmental disorder. Two such cases are described where the patients underwent psychiatric and neuropsychological examination before and after treatment with risperidone, a potent 5-HT2 antagonist with additional D2 antagonistic properties. Particular improvements were documented in both patients, despite long histories of cognitive compromise and high likelihood of damage to the central nervous system.
authors.affiliation: Department of Psychiatry, University of Alberta, Edmonton, Canada.
authors.forename: S E
authors.initials: SE
authors.lastname: Purdon
authors.forename: W
authors.initials: W
authors.lastname: Lit
authors.forename: A
authors.initials: A
authors.lastname: Labelle
authors.forename: B D
authors.initials: BD
authors.lastname: Jones
mesh_terms: D000293:Adolescent; D000328:Adult; D014150:Antipsychotic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D001321:Autistic Disorder / Q000097:blood / Q000188:drug therapy / Q000523:psychology; D002648:Child; D002659:Child Development Disorders, Pervasive / Q000097:blood / Q000188:drug therapy* / Q000523:psychology; D005500:Follow-Up Studies; D006801:Humans; D008607:Intellectual Disability / Q000097:blood / Q000188:drug therapy / Q000523:psychology; D007555:Isoxazoles / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D009483:Neuropsychological Tests; D010880:Piperidines / Q000009:adverse effects / Q000627:therapeutic use*; D018967:Risperidone; D012701:Serotonin / Q000097:blood; D013239:Stereotyped Behavior / Q000187:drug effects
chemical_list: D014150:Antipsychotic Agents; D007555:Isoxazoles; D010880:Piperidines; D012701:Serotonin; D018967:Risperidone