title: [Palliative treatment by endoprosthesis of icterus caused by distal biliary tumoral obstruction].
abstract: Between March 1982 and December 1987, 466 patients (256 women, 210 men, mean age 73 years) with tumor obstruction of the common bile duct were referred to our department. The causes of obstruction were carcinoma of the pancreas (298 patients), carcinoma of the ampulla of Vater (32 patients) and carcinoma of the common bile duct (136 patients). Endoscopical insertion of a biliary prosthesis was initially possible in 377 patients (81%). In case of failure, patients were referred to the radiologist for percutaneous drainage. Successful drainage was obtained in 58 patients with an overall success rate of 93% (435 patients). Endoscopic replacement was necessary in 170 cases for 114 patients and was successful in 155 (91%). Pruritus was relieved in 89% of the patients. Serum bilirubin levels decreased more than 75% after initial endoscopic endoprosthesis, repeated endoscopic endoprosthesis and percutaneous prosthesis insertion in 80%, 79%, and 62% of the patients, respectively. Short term complications of endoscopic endoprosthesis occurred in 28% of patients with a mortality rate of 8%. Percutaneous prosthesis complications occurred in 33% of patients with a mortality rate of 11%. In the long term, cholangitis was the main complication and occurred in 27% of patients with a delay of 103 +/- 105 days. Intestinal obstruction was observed in 7% of patients. The average life expectancy of endoscopic endoprosthesis and percutaneous prosthesis was 109 +/- 157 and 92 +/- 101 days, respectively. The average life expectancy of patients was 163 +/- 224 days.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Service des Maladies, Centre Hospitalier de Bicêtre, Le Kremlin-Bicêtre.
authors.forename: C
authors.initials: C
authors.lastname: Buffet
authors.forename: T
authors.initials: T
authors.lastname: Couderc
authors.forename: J
authors.initials: J
authors.lastname: Fritsch
authors.forename: A
authors.initials: A
authors.lastname: Choury
authors.forename: J F
authors.initials: JF
authors.lastname: Lefebvre
authors.forename: V
authors.initials: V
authors.lastname: Marteau
authors.forename: O
authors.initials: O
authors.lastname: Ink
authors.forename: D
authors.initials: D
authors.lastname: Bonnel
authors.forename: C
authors.initials: C
authors.lastname: Liguory
authors.forename: J P
authors.initials: JP
authors.lastname: Etienne
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002761:Cholangitis / Q000209:etiology / Q000401:mortality; D001651:Cholestasis, Extrahepatic / Q000209:etiology / Q000401:mortality / Q000628:therapy*; D003138:Common Bile Duct Neoplasms / Q000150:complications* / Q000473:pathology; D016145:Endoscopy, Digestive System / Q000379:methods; D005260:Female; D006801:Humans; D007440:Intubation / Q000009:adverse effects / Q000379:methods*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000150:complications* / Q000473:pathology; D011183:Postoperative Complications; D015607:Stents