The effects of a long term treatment with cyclophosphamide on the thymus and on some blood parameters in Wistar rats.
Adult Wistar rats of both sexes were treated with Cyclophosphamide (a Romanian product), for 12 month. The Cyclophosphamide was given in the food, in 3 different doses (0.31, 1.25, respectively 2.5 mg/kg body weight). The modifications produced in the thymus and blood plasma were dose and sex dependent, and they emphasize an alteration in the protein metabolism, which is not accompanied by an involuntion of the thymus itself.
Giurgea
R
R
Institute of Biological Research, Cluj-Napoca Faculty of Biology, Cluj-Napoca.
Roşioru
C
C
Roman
I
I
D000588:Amines / Q000097:blood; D000818:Animals; D001769:Blood / Q000187:drug effects*; D001798:Blood Proteins / Q000032:analysis / Q000187:drug effects; D003520:Cyclophosphamide / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009584:Nitrogen / Q000097:blood; D012313:RNA / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D013950:Thymus Gland / Q000187:drug effects* / Q000378:metabolism; D013997:Time Factors
D000588:Amines; D001798:Blood Proteins; D012313:RNA; D003520:Cyclophosphamide; D009584:Nitrogen