title: Leptomeningeal infiltration in esthesioneuroblastoma: report of two cases with poor prognosis.
abstract: Esthesioneuroblastoma is a rare neoplasm of neuroectodermal origin, arising from the olfactory epithelium in the roof of the nasal cavity. Extension to the brain can occur less frequently than local recurrence, but leptomeningeal metastases without brain involvement have rarely been mentioned. We report 2 cases with poor prognosis of leptomeningeal infiltration during the evolution of esthesioneuroblastoma.
authors.affiliation: Unité CNRS 1340, Hôpital G.R.-Laennec, Nantes, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Louboutin
authors.forename: C
authors.initials: C
authors.lastname: Maugard-Louboutin
authors.forename: P
authors.initials: P
authors.lastname: Fumoleau
mesh_terms: D000293:Adolescent; D000368:Aged; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D016371:Cranial Irradiation; D018304:Esthesioneuroblastoma, Olfactory / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology / Q000556:secondary* / Q000628:therapy; D008578:Meninges / Q000473:pathology; D010166:Palliative Care; D010255:Paranasal Sinus Neoplasms / Q000473:pathology / Q000628:therapy*; D011379:Prognosis; D014057:Tomography, X-Ray Computed