Pinocytic stimulation in Dictyostelium discoideum by gamma-benzene hexachloride.
Pinocytic activity is greatly stimulated in gamma-BHC (gamma isomer of benzene hexachloride) treated, vegetative cells of Dictyostelium discoideum as measured by 14C sucrose or FITC-dextran uptake. Transmission electron microscopic studies also reveal the presence of a greater number of pinosomal vesicles in the pesticide-treated Dictyostelium amoebae. The enhanced pinocytic activity has been discussed in relation to lipophilic interactions of gamma-BHC with the hydrophobic cell surface and the observed changes in the cytoskeletal proteins of the treated cells.
Gayatri
R
R
School of Life Sciences, Jawaharlal Nehru University, New Delhi, India.
Chatterjee
S
S
D000818:Animals; D002250:Carbon Radioisotopes; D002462:Cell Membrane / Q000502:physiology / Q000648:ultrastructure; D003911:Dextrans / Q000493:pharmacokinetics; D004023:Dictyostelium / Q000502:physiology* / Q000648:ultrastructure; D004591:Electrophoresis, Polyacrylamide Gel; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D008854:Microscopy, Electron; D010873:Pinocytosis / Q000187:drug effects*; D013395:Sucrose / Q000493:pharmacokinetics
D002250:Carbon Radioisotopes; D003911:Dextrans; C015219:fluorescein isothiocyanate dextran; D013395:Sucrose; D001556:Hexachlorocyclohexane; D016650:Fluorescein-5-isothiocyanate