title: Antimutagenicity of lemon grass (Cymbopogon citratus Stapf) to various known mutagens in salmonella mutation assay.
abstract: Lemon grass (Cymbopogon citratus Stapf) was extracted with 80% ethanol. The extract was not found to be mutagenic in the Salmonella mutation test with or without metabolic activation. However, the extract was found to possess antimutagenic properties towards chemical-induced mutation in Salmonella typhimurium strains TA98 and TA100. Mutagenicity of AFB1, Trp-P-1, Trp-P-2, Glu-P-1, Glu-P-2, IQ, MNNG and AF-2, was inhibited by the extract of lemon grass in a dose-dependent manner, but no effect was found on the mutagenic activity of benzo[a]pyrene.
authors.affiliation: Department of Biochemistry, Faculty of Medicine, Chiang Mai University, Thailand.
authors.forename: U
authors.initials: U
authors.lastname: Vinitketkumnuen
authors.forename: R
authors.initials: R
authors.lastname: Puatanachokchai
authors.forename: P
authors.initials: P
authors.lastname: Kongtawelert
authors.forename: N
authors.initials: N
authors.lastname: Lertprasertsuke
authors.forename: T
authors.initials: T
authors.lastname: Matsushima
mesh_terms: D016587:Antimutagenic Agents / Q000494:pharmacology*; D001711:Biotransformation; D004305:Dose-Response Relationship, Drug; D009152:Mutagenicity Tests; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D006109:Poaceae; D012485:Salmonella typhi / Q000187:drug effects
chemical_list: D016587:Antimutagenic Agents; D010936:Plant Extracts