Selective loss of NADPH-diaphorase-containing neurons in the dentate gyrus following transient ischemia.
The effect of transient forebrain ischemia on NADPH-diaphorase-containing neurons was examined in the dentate gyrus of the gerbil. NADPH-diaphorase histochemistry was performed in animals subjected to temporary occlusion of the common carotid arteries and sham-operated animals. Seven days following transient ischemia, the number of NADPH-diaphorase-positive neurons in the infragranular zone of the dentate gyrus was reduced by approximately 50% compared with control animals. Since neighboring granule cells are known to be resistant to this level of ischemic challenge, the present observations indicate that NADPH-diaphorase-containing neurons in the dentate gyrus are selectively vulnerable to brief ischemia.
Hong
S C
SC
Department of Neurological Surgery, University of Virginia, Charlottesville 22908.
Lanzino
G
G
Collins
J
J
Kassell
N F
NF
Lee
K S
KS
D000594:Amino Acid Oxidoreductases / Q000032:analysis; D000818:Animals; D005849:Gerbillinae; D006624:Hippocampus / Q000201:enzymology / Q000473:pathology*; D002546:Ischemic Attack, Transient / Q000201:enzymology / Q000473:pathology*; D009252:NADPH Dehydrogenase / Q000032:analysis*; D009474:Neurons / Q000201:enzymology / Q000473:pathology*; D019001:Nitric Oxide Synthase; D016548:Prosencephalon
D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D009252:NADPH Dehydrogenase