Influences of alkylphenyl alpha-D-mannopyranosides on histamine release from rat peritoneal mast cells induced by concanavalin A.
The influence of mannose, glucose, galactose and their corresponding methyl and phenyl glycopyranosides, as well as a series of alkylphenyl alpha-D-mannopyranosides, on histamine release from rat peritoneal mast cells induced by concanavalin A was examined. Among the compounds tested, the inhibitory effects of compounds bearing a 2,6-dimethyl substituent were stronger than the others. The results suggest that the binding ability of phenyl alpha-D-mannopyranoside may be markedly enhanced by the introduction of a 2,6-dimethyl substituent into the benzene nuclei of aglycones.
Wang
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TC
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Kakegawa
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Matsumoto
H
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Satoh
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T
D000818:Animals; D003208:Concanavalin A / Q000494:pharmacology*; D005690:Galactose / Q000494:pharmacology; D005947:Glucose / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D008297:Male; D008358:Mannose / Q000494:pharmacology; D008362:Mannosides / Q000138:chemical synthesis / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D010537:Peritoneum / Q000166:cytology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013329:Structure-Activity Relationship
D008362:Mannosides; D003208:Concanavalin A; D005947:Glucose; D008358:Mannose; D005690:Galactose