Neurochemical profiles in cerebrospinal fluid of stroke-prone spontaneously hypertensive rats.
The purpose of the present study was to evaluate stroke-prone spontaneously hypertensive rats (SHRSP) neurochemically by determining the cerebrospinal fluid (CSF) levels of acetylcholine (ACh), norepinephrine (NE) and serotonin (5-HT) as an index of central neuronal activity. The CSF ACh levels of 15- to 20-week-old SHRSP were significantly lower than those of age-matched Wistar Kyoto rats (WKY) both under the urethane/alpha-chloralose anesthesia and in freely moving conditions. The difference in the CSF ACh levels between SHRSP and WKY was more marked at 30-40 weeks. Sustained changes were not observed in the CSF NE and 5-HT levels. Thus, the progressive dysfunction in the central cholinergic system may characterize the pathophysiological state of this animal model with cerebral lesions caused by continuous high blood pressure.
Togashi
H
H
First Department of Pharmacology, Hokkaido University School of Medicine, Sapporo, Japan.
Matsumoto
M
M
Yoshioka
M
M
Hirokami
M
M
Minami
M
M
Saito
H
H
D015102:3,4-Dihydroxyphenylacetic Acid / Q000134:cerebrospinal fluid; D000109:Acetylcholine / Q000134:cerebrospinal fluid; D000818:Animals; D015306:Biogenic Monoamines / Q000134:cerebrospinal fluid*; D001794:Blood Pressure / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000134:cerebrospinal fluid* / Q000235:genetics; D006719:Homovanillic Acid / Q000134:cerebrospinal fluid; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid; D008297:Male; D017551:Microdialysis; D009638:Norepinephrine / Q000134:cerebrospinal fluid; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY; D012701:Serotonin / Q000134:cerebrospinal fluid
D015306:Biogenic Monoamines; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D000109:Acetylcholine; D009638:Norepinephrine; D006719:Homovanillic Acid