Monoamine-activated alpha 2-macroglobulin inhibits neurite outgrowth, survival, choline acetyltransferase, and dopamine concentration of neurons by blocking neurotrophin-receptor (trk) phosphorylation and signal transduction.
Koo
P H
PH
Department of Microbiology and Immunology, Northeastern Ohio Universities College of Medicine, Rootstown 44272.
Liebl
D J
DJ
Qiu
W S
WS
Hu
Y Q
YQ
Dluzen
D E
DE
D000818:Animals; D015306:Biogenic Monoamines / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D002795:Choline O-Acetyltransferase / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism; D006801:Humans; D007231:Infant, Newborn; D016501:Neurites / Q000502:physiology; D009474:Neurons / Q000502:physiology; D010766:Phosphorylation / Q000187:drug effects; D016548:Prosencephalon / Q000166:cytology / Q000502:physiology*; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000187:drug effects*; D017475:Receptors, Nerve Growth Factor / Q000187:drug effects*; D015398:Signal Transduction / Q000187:drug effects*; D013045:Species Specificity; D000511:alpha-Macroglobulins / Q000494:pharmacology*
D015306:Biogenic Monoamines; D017475:Receptors, Nerve Growth Factor; D000511:alpha-Macroglobulins; D002795:Choline O-Acetyltransferase; D020794:Receptor Protein-Tyrosine Kinases; D004298:Dopamine