[The lysosomal hydrolase activity in the blood of patients with inflammatory processes in the parotid gland with surgical pathology of the organs of the abdominal cavity].
Activities of lysosomal enzymes (acid phosphatase, beta-galactosidase, cathepsin D) were measured in the blood of 38 patients with acute nonepidemic parotitis, caused by surgical diseases of the abdominal organs, and the status of glutathion antioxidant system studied. When appearing in the blood, lysosomal enzymes were found to join the chain cytolytic process or local proteolysis reactions, thus possibly becoming an important pathogenetic component in the development of acute parotitis induced by surgical diseases of the abdominal organs. The authors come to a conclusion about contribution of lysosomal enzymes to the mechanisms of impairment of the parotid gland, an increased level of these enzymes in the blood being indicative of pathologic changes on tissues. The authors emphasize that current approaches to pathogenetic treatment of acute nonepidemic parotitis should be revised.
Dolgov
S N
SN
Filipenko
P S
PS
D000005:Abdomen / Q000601:surgery*; D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D004796:Clinical Enzyme Tests / Q000706:statistics & numerical data; D005260:Female; D006801:Humans; D006867:Hydrolases / Q000097:blood*; D015227:Lipid Peroxidation; D008247:Lysosomes / Q000201:enzymology*; D008297:Male; D008875:Middle Aged; D010309:Parotitis / Q000175:diagnosis* / Q000209:etiology
D006867:Hydrolases