[The mechanism of the anti-arrhythmia action of opioid receptor agonists and antagonists].
Enkephalins were injected intravenously at a dose of 0.1 mg/kg 15 minutes or 6 hours before adrenalin or CaCl2 injection. Enkephalins were reported to prevent adrenal ventricular extrasystoles but not to influence CaCl2-induced dysrhythmias. Maximum antiarrhythmic effect of enkephalins was demonstrated 6 hours later after the intravenous injection. Naloxone at a dose of 2 mg/kg and morphine at a dose of 1.5 mg/kg prevent adrenal arrhythmias 15 min and 6 hours later after injection. We believe that peripheral delta opiate receptors activation by enkephalins as well as the blockade of non-identified opiate receptors by naloxone prevent arrhythmias.
Maslov
L N
LN
Lishmanov
Iu B
IuB
Székely
J I
JI
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology* / Q000627:therapeutic use; D002122:Calcium Chloride; D005117:Cardiac Complexes, Premature / Q000139:chemically induced / Q000517:prevention & control; D004353:Drug Evaluation, Preclinical; D004745:Enkephalins / Q000494:pharmacology* / Q000627:therapeutic use; D004837:Epinephrine; D008024:Ligands; D008297:Male; D009270:Naloxone / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D011957:Receptors, Opioid / Q000187:drug effects*; D013997:Time Factors
D000889:Anti-Arrhythmia Agents; D004745:Enkephalins; D008024:Ligands; D011957:Receptors, Opioid; D009270:Naloxone; D002122:Calcium Chloride; D004837:Epinephrine