Chromosome studies in Alzheimer's disease patients: distribution of dicentric breakpoints in lymphocytes irradiated in vitro.
A previous study showed a significant increase in dicentric frequency in lymphocytes irradiated in vitro from non-familial Alzheimer's disease patients compared to normal age-matched controls. This study examined the distribution of the chromosome breakpoints involved in the dicentric formation and found a non-specific increase in all chromosomes.
Shippey
C A
CA
Genetics Unit, Geoffrey Schofield Laboratories, British Nuclear Fuels plc, Westlakes Science and Technology Park, Moor Rowe, Cumbria, UK.
Tobi
S E
SE
Itzhaki
R F
RF
Tawn
E J
EJ
D000544:Alzheimer Disease / Q000235:genetics*; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D004260:DNA Repair; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male