title: [Analysis of ovalbumin-specific T cell lines established from patients with hen egg allergy].
abstract: Ten ovalbumin (OVA)-specific T cell lines (TCLs) were established from peripheral blood mononuclear cells of 6 patients with hen egg allergy, and the antigen recognition of these TCLs was characterized. Two OVA epitopes were determined by use of 3 synthetic OVA peptides which have been known as murine T cell epitopes. Blocking of antigen-specific T cell proliferation by anti-HLA class II monoclonal antibodies suggest that all 3 HLA class II molecules could act as restriction elements for T cell recognition of OVA. This is the first demonstration of OVA epitopes recognized by T cells in patients with hen egg allergy, as far as we know.
authors.affiliation: Department of Pediatrics, Chiba University School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Katsuki
authors.forename: N
authors.initials: N
authors.lastname: Shimojo
authors.forename: K
authors.initials: K
authors.lastname: Honma
authors.forename: Y
authors.initials: Y
authors.lastname: Kohno
authors.forename: H
authors.initials: H
authors.lastname: Niimi
authors.forename: J E
authors.initials: JE
authors.lastname: Coligan
authors.forename: H
authors.initials: H
authors.lastname: Tsunoo
mesh_terms: D002460:Cell Line; D002648:Child; D002675:Child, Preschool; D004531:Eggs; D000939:Epitopes / Q000276:immunology; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D007223:Infant; D008297:Male; D010047:Ovalbumin / Q000276:immunology*; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology*
chemical_list: D000939:Epitopes; D010047:Ovalbumin