Glucocorticoid negative feedback in pituitary corticotropes. Pivotal role for calcineurin inhibition of adenylyl cyclase.
Shipston
M J
MJ
Department of Pharmacology, University of Edinburgh, Scotland, UK.
Hernando
F
F
Barnard
R J
RJ
Antoni
F A
FA
D000067956:Adenylyl Cyclase Inhibitors; D000324:Adrenocorticotropic Hormone / Q000378:metabolism*; D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D019703:Calcineurin; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D002148:Calmodulin-Binding Proteins / Q000502:physiology*; D002460:Cell Line; D003346:Corticotropin-Releasing Hormone / Q000494:pharmacology*; D000242:Cyclic AMP / Q000378:metabolism; D016572:Cyclosporine / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004533:Egtazic Acid / Q000494:pharmacology; D005246:Feedback; D051379:Mice; D009553:Nimodipine / Q000494:pharmacology; D010749:Phosphoprotein Phosphatases / Q000502:physiology*; D010902:Pituitary Gland / Q000187:drug effects / Q000502:physiology; D010911:Pituitary Neoplasms; D016559:Tacrolimus / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000067956:Adenylyl Cyclase Inhibitors; D002148:Calmodulin-Binding Proteins; D000001:Calcimycin; D004533:Egtazic Acid; D009553:Nimodipine; D003907:Dexamethasone; D016572:Cyclosporine; D000324:Adrenocorticotropic Hormone; D003346:Corticotropin-Releasing Hormone; D000242:Cyclic AMP; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases; D002118:Calcium; D016559:Tacrolimus