Solid cell nests of the thyroid in medullary thyroid carcinoma.
Solid cell nests of the thyroid gland were studied in 44 patients with medullary thyroid carcinoma. In 10 (22.7%) patients, solid cell nests were revealed in the vicinity of tumour foci (five cases) or in the contralateral thyroid lobe and isthmus (four cases); in one case the location was indeterminate. In all seven cases in which immunohistochemical studies were carried out, solid cell nests showed negative staining for thyroglobulin, calcitonin and chromogranin A, findings which were distinct from those in medullary thyroid carcinoma. It is therefore suggested that solid cell nests of the thyroid are not precursors of this tumour.
Ozaki
O
O
Surgical Branch, Ito Hospital, Tokyo, Japan.
Ito
K
K
Fujisawa
T
T
Kawano
M
M
Iwabuchi
H
H
Kitamura
Y
Y
Sugino
K
K
Mimura
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D002272:Carcinoembryonic Antigen / Q000032:analysis; D018276:Carcinoma, Medullary / Q000473:pathology*; D002648:Child; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D009418:S100 Proteins / Q000032:analysis; D013961:Thyroid Gland / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000473:pathology*
D002272:Carcinoembryonic Antigen; D009418:S100 Proteins; D007633:Keratins