Co-expression of endothelial cell and macrophage antigens in Kaposi's sarcoma cells.
The histopathogenesis of Kaposi's sarcoma (KS) was investigated using immunocytochemistry in 12 skin biopsies obtained from two AIDS patients, nine patients with the classic form, and one organ-transplant patient. KS cells revealed a peculiar antigenic profile, being characterized by co-expression of endothelial and macrophage markers. KS cells were stained for von Willebrand factor (vWF); for vascular endothelial (VE) cadherin, an endothelial specific adhesion molecule; and for PECAM/CD31. In addition, they expressed the macrophage antigens PAM-1, CD68, and CD14, and were positive for vitronectin receptor and alpha-1,5,6/beta-1 integrins. KS cells were weakly stained for ICAM-1 in 6 of 12 cases and were negative for VCAM-1 and E-selectin.
Uccini
S
S
II Pathological Anatomy, University La Sapienza, Roma, Italy.
Ruco
L P
LP
Monardo
F
F
Stoppacciaro
A
A
Dejana
E
E
La Parola
I L
IL
Cerimele
D
D
Baroni
C D
CD
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology*; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D002196:Capillaries; D015815:Cell Adhesion Molecules / Q000032:analysis; D004729:Endothelium, Lymphatic / Q000473:pathology*; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016023:Integrins / Q000032:analysis; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D018950:Lipopolysaccharide Receptors; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D016024:Receptors, Cytoadhesin / Q000032:analysis; D019030:Receptors, Vitronectin; D012514:Sarcoma, Kaposi / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D019010:Vascular Cell Adhesion Molecule-1; D014841:von Willebrand Factor / Q000032:analysis; D000097382:CD68 Molecule
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D016023:Integrins; D018799:Intercellular Adhesion Molecule-1; D018950:Lipopolysaccharide Receptors; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D016024:Receptors, Cytoadhesin; D019030:Receptors, Vitronectin; D019010:Vascular Cell Adhesion Molecule-1; D014841:von Willebrand Factor; C067980:CD68 antigen, human; D000097382:CD68 Molecule