Ultrasonography endometrial patterns in different hormonal treatments to induce ovulation.
As several studies report that transvaginal ultrasound of endometrial thickness may help distinguish fertile from infertile cycles, we assessed endometrial growth and morphology in 124 infertile women. The patients underwent different ovulation induction treatments: clomiphene citrate (CC), human menopausal gonadotropin (hMG) and human chorionic gonadotropin (hCG), analogous Gn-RH and hMG (aGn-RH+hMG). CC administration is followed by a slackening of endometrial maturation. The US pattern H (typical of the ovulatory phase) appears on day 13 (76.9% of the cases) in spontaneous cycles and on day 16 (75% of the cases) in CC-induced cycles. The H pattern on day 20 in CC-induced cycles persisted in the patients who did not conceive. In aGn-RH-stimulated cycles the endometrial pattern H appears on days 13 (41.66%) and 16 (83.33%), not preceded by a Hi image. The endometrial pattern Hi was always observed in the patients who did not conceive. Our retrospective study of endometrial US morphology shows that the different ovulation induction treatments may affect the day of appearance of the various endometrial patterns. These results, which need further confirmation, can allow the changes of conceiving to be investigated during the stimulation protocol of every single stimulated cycle.
Beneventi
F
F
Clinica Ostetrica e Ginecologia, Policlinico San Matteo IRCSS, Università degli Studi di Pavia.
Sampaolo
P
P
Polatti
F
F
Filoni
G M
GM
Masanti
M L
ML
Persiani
P
P
Zara
C
C
D000328:Adult; D016009:Chi-Square Distribution; D006063:Chorionic Gonadotropin / Q000008:administration & dosage*; D002996:Clomiphene / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D004717:Endometrium / Q000000981:diagnostic imaging* / Q000187:drug effects; D005260:Female; D005300:Fertility Agents, Female / Q000008:administration & dosage*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage*; D006801:Humans; D007247:Infertility, Female / Q000000981:diagnostic imaging / Q000188:drug therapy; D008596:Menotropins / Q000008:administration & dosage*; D008597:Menstrual Cycle / Q000187:drug effects; D010062:Ovulation Induction / Q000379:methods*; D012189:Retrospective Studies; D013997:Time Factors; D014463:Ultrasonography / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D002996:Clomiphene; D007987:Gonadotropin-Releasing Hormone; D008596:Menotropins