Role of CD40-CD40-ligand interaction in Ig-isotype switching.
Ig-isotype switching to IgE requires interleukin-4 and a contact-dependent T-cell signal delivered by the ligand for CD40. The recent discovery that defects in the gene encoding the CD40 ligand are the underlying cause of the X-linked hyper IgM syndrome highlights the role of CD40 and its ligand in Ig-isotype switching.
Fuleihan
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R
Children's Hospital, Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115.
Ramesh
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N
Geha
R S
RS
D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000502:physiology*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000235:genetics / Q000502:physiology*; D019013:CD40 Antigens; D023201:CD40 Ligand; D006801:Humans; D017578:Immunoglobulin Class Switching / Q000276:immunology*; D007153:Immunologic Deficiency Syndromes / Q000235:genetics / Q000276:immunology; D008024:Ligands; D008562:Membrane Glycoproteins / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000276:immunology
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D019013:CD40 Antigens; D008024:Ligands; D008562:Membrane Glycoproteins; D023201:CD40 Ligand