An additional HpaII polymorphism in exon 2 of the human platelet membrane glycoprotein IIIa gene.
A novel HpaII polymorphic site caused by a T-->G transversion at codon 40 of the GP3a locus is described. It was found together with another polymorphic HpaII site at codon 33. Both are associated with the immunologically defined HPA-1b antigen.
Perichon
B
B
INSERM U 120, Hôpital Robert Debré, Paris, France.
Clemenceau
S
S
Romand
A
A
Elion
J
J
Kaplan
C
C
Krishnamoorthy
R
R
D016824:Antigens, Human Platelet / Q000235:genetics; D001483:Base Sequence; D002874:Chromosome Mapping; D002886:Chromosomes, Human, Pair 17; D004247:DNA; D019003:Deoxyribonuclease HpaII; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism; D005091:Exons; D006801:Humans; D008969:Molecular Sequence Data; D010980:Platelet Membrane Glycoproteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D016824:Antigens, Human Platelet; D010980:Platelet Membrane Glycoproteins; C083451:human platelet antigen 1b; D004247:DNA; D019003:Deoxyribonuclease HpaII; D015252:Deoxyribonucleases, Type II Site-Specific