E-selectin and interleukin-2 receptor alpha-chain expression in alopecia universalis.
A study of the histopathological abnormalities in a case of alopecia universalis was accompanied by immunohistochemical analysis of the expression of intercellular adhesion molecule-1 (ICAM-1) and E-selectin (formerly known as endothelial leukocyte adhesion molecule-1) within the skin. ICAM-1 expression on follicular epithelium co-localized with intraepithelial mononuclear cells (MNC) positive for the interleukin-2 receptor alpha-chain (IL-2R) or HLA-DR. Aberrant expression of E-selectin was observed on dermal endothelium. Although restricted to one case, these new observations concerning the expression of E-selectin and IL-2R in alopecia universalis are consistent with the view that extravascular trafficking of MNC into follicular epithelium may play a key role in the pathogenesis of alopecia universalis and that use of agents that interfere with this process may be an effective therapeutic strategy.
Rilo
H L
HL
Department of Surgery, University of Pittsburgh Medical Center, PA.
Carroll
P B
PB
Subbotin
V
V
Johnson
N
N
Van Thiel
D H
DH
Thomson
A W
AW
D000328:Adult; D000505:Alopecia / Q000276:immunology* / Q000378:metabolism* / Q000473:pathology; D015703:Antigens, CD / Q000096:biosynthesis*; D015815:Cell Adhesion Molecules / Q000096:biosynthesis*; D019040:E-Selectin; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D005260:Female; D006197:Hair / Q000378:metabolism / Q000473:pathology; D006801:Humans; D018799:Intercellular Adhesion Molecule-1; D007963:Leukocytes, Mononuclear / Q000378:metabolism / Q000473:pathology; D011971:Receptors, Immunologic / Q000096:biosynthesis*; D015375:Receptors, Interleukin-2 / Q000096:biosynthesis*
D015703:Antigens, CD; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D011971:Receptors, Immunologic; D015375:Receptors, Interleukin-2; D018799:Intercellular Adhesion Molecule-1