[Thieno(2',3':3,4)pyrazolo(1,5-a)pyrimidines and -triazines: synthesis of a novel ring system].
The novel tricyclic ring systems 14 can be prepared by reaction of thienopyrazoles 5 with 1,3-dielectrophiles, such as acetylacetone, dibenzoylmethane or 1,2,4-dithiazole 8. An other synthetic route for the preparation of the tricyclic systems, based on the pyrazoloazines 13, was investigated. The compounds 5 and 14 were tested for antiulcer activity.
Briel
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Institut für Pharmazie, Universität Leipzig.
D000818:Animals; D000897:Anti-Ulcer Agents / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D011720:Pyrazoles / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D011743:Pyrimidines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity; D051381:Rats; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology / Q000633:toxicity
D000897:Anti-Ulcer Agents; D011720:Pyrazoles; D011743:Pyrimidines; D014227:Triazines