title: Sugar-DNA molecular recognition: specific interaction of alpha-1,4-glucopyranose chains with DNA in the minor groove.
abstract: alpha(1,4) glucopyranose chains (dextrins) are shown to interact with DNA via hydrophobic interactions from the minor groove side, while alpha(1,6) dextrans do not bind DNA. The observed specific alpha(1,4) linked sugar-DNA interactions may have importance in recognition of DNA by ene-diyne class of antibiotics via their saccharide units which have mostly alpha(1,4) linkages.
authors.affiliation: Division of Organic Chemistry, National Chemical Laboratory, Pune, India.
authors.forename: A G
authors.initials: AG
authors.lastname: Krishna
authors.forename: D
authors.initials: D
authors.lastname: Balasubramanian
authors.forename: K N
authors.initials: KN
authors.lastname: Ganesh
mesh_terms: D001483:Base Sequence; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D004247:DNA / Q000737:chemistry*; D003911:Dextrans / Q000737:chemistry; D003912:Dextrins / Q000737:chemistry*; D008320:Maltose / Q000737:chemistry; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009429:Netropsin / Q000737:chemistry; D009690:Nucleic Acid Conformation; D009838:Oligodeoxyribonucleotides / Q000138:chemical synthesis / Q000737:chemistry*; D013050:Spectrometry, Fluorescence; D014312:Trisaccharides / Q000737:chemistry
chemical_list: D003911:Dextrans; D003912:Dextrins; D009838:Oligodeoxyribonucleotides; D014312:Trisaccharides; C008317:maltotriose; D009429:Netropsin; D008320:Maltose; D004247:DNA