Immunotropic activity of lupin seeds extracts and fractions from Lupinus angustifolius and Lupinus albus.
The results demonstrated immunotropic activity of seeds extracts and fractions from Lupinus angustifolius and Lupinus albus. Plaque forming cells (PFC) number to SRBC (sheep red blood cells) were elevated by an extract from Lupinus angustifolius and lowered by extracts from Lupinus albus. All preparations obtained from Lupinus angustifolius reduced the number of rosette forming cells (E-RFC). These preparations suppressed also the intensity of graft versus host reaction (GVHR) in case when the donors were treated. Lupinus albus extract suppressed GVH reaction when recipients were treated. Lupin extracts stimulated draining popliteal lymph nodes in PLN assay.
Błaszczyk
B
B
Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław.
Stobiecki
M
M
Kowalczyk-Bronisz
S H
SH
Gulewicz
K
K
Szymaniec
S
S
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects / Q000276:immunology; D006968:Hypersensitivity, Delayed / Q000276:immunology; D007075:Immunoglobulin M / Q000276:immunology; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D010936:Plant Extracts / Q000494:pharmacology*; D012397:Rosette Formation; D012639:Seeds / Q000737:chemistry; D012756:Sheep
D000276:Adjuvants, Immunologic; D007075:Immunoglobulin M; D010936:Plant Extracts