title: Effects of short-term high-dose testosterone propionate administration on medium molecular-weight proteins of human seminal plasma.
abstract: Effects of short-term high-dose testosterone propionate treatment on medium molecular-weight proteins (lactoferrin, albumin, prostatic acid phosphatase, prostate specific antigen) and on zinc and fructose levels were investigated in the seminal plasma of seven normal volunteers. A significant reduction in levels of prostatic-acid phosphatase, zinc and, to a lesser degree, prostate-specific antigen, lactoferrin and fructose was observed on the 14th day of androgen treatment, concomitantly with the maximal increase in free androgen-circulating levels. The data obtained suggest that testosterone administration may induce a reduction in the sex accessory-gland secretion. Indeed, this effect tends to disappear with withdrawal of hormone treatment. Therefore, the authors suggest a close follow-up of prostatic and vesicular function during the long-term high-dose testosterone intake, used frequently as anabolic treatment by athletes and body builders.
authors.affiliation: Department of Cellular Biology, University of Calabria, Cosenza, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Carpino
authors.forename: D
authors.initials: D
authors.lastname: Sisci
authors.forename: S
authors.initials: S
authors.lastname: Aquila
authors.forename: E
authors.initials: E
authors.lastname: Beraldi
authors.forename: M T
authors.initials: MT
authors.lastname: Sessa
authors.forename: L
authors.initials: L
authors.lastname: Siciliano
authors.forename: G
authors.initials: G
authors.lastname: De Luca
authors.forename: S
authors.initials: S
authors.lastname: Andò
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D000418:Albumins / Q000378:metabolism; D013196:Dihydrotestosterone / Q000097:blood; D005632:Fructose / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism; D007781:Lactoferrin / Q000378:metabolism; D008297:Male; D011467:Prostate / Q000201:enzymology; D017430:Prostate-Specific Antigen / Q000378:metabolism; D029584:Prostatic Secretory Proteins; D011506:Proteins / Q000302:isolation & purification / Q000378:metabolism*; D011863:Radioimmunoassay; D012661:Semen / Q000187:drug effects / Q000378:metabolism*; D029589:Seminal Plasma Proteins; D013739:Testosterone / Q000097:blood / Q000494:pharmacology*; D015032:Zinc / Q000378:metabolism
chemical_list: D000418:Albumins; D007527:Isoenzymes; D029584:Prostatic Secretory Proteins; D011506:Proteins; D029589:Seminal Plasma Proteins; C043076:beta-microseminoprotein; D013196:Dihydrotestosterone; D005632:Fructose; D013739:Testosterone; D000135:Acid Phosphatase; D007781:Lactoferrin; D017430:Prostate-Specific Antigen; D015032:Zinc