Inhibition of endogenous dopamine release in amphibian retina by L-2-amino-4-phosphonobutyric acid (L-AP4) and trans-2-aminocyclopentane-1,3-dicarboxylate (ACPD).
The metabotropic glutamate receptor agonists 2-amino-4-phosphonobutyric acid (AP4) and trans-2-aminocyclopentane-1,3-dicarboxylate (ACPD) blocked light-stimulated dopamine release from Xenopus laevis retina. ACPD suppressed release in darkness but AP4 did not. AP4 blocked release stimulated in darkness by picrotoxin, a GABA-A receptor antagonist. The data suggest that regulation of dopamine release in Xenopus retina involves subpopulations of metabotropic glutamate receptors.
Boatright
J H
JH
Department of Pharmacology, Emory University School of Medicine, Atlanta, GA 30322-3090.
Gordon
J R
JR
Iuvone
P M
PM
D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D003515:Cycloleucine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D007473:Ion Channels / Q000187:drug effects / Q000378:metabolism; D008027:Light; D009498:Neurotoxins / Q000494:pharmacology*; D010852:Picrotoxin / Q000494:pharmacology; D018094:Receptors, Metabotropic Glutamate / Q000819:agonists*; D012160:Retina / Q000378:metabolism*; D017949:Retinal Cone Photoreceptor Cells / Q000187:drug effects / Q000378:metabolism; D017948:Retinal Rod Photoreceptor Cells / Q000187:drug effects / Q000378:metabolism; D013237:Stereoisomerism; D014982:Xenopus laevis
D000613:Aminobutyrates; D003515:Cycloleucine; D004298:Dopamine; D007473:Ion Channels; D009498:Neurotoxins; D010852:Picrotoxin; D018094:Receptors, Metabotropic Glutamate; C036361:1-amino-1,3-dicarboxycyclopentane; C012729:2-amino-4-phosphonobutyric acid