Steroidogenic impairment after lindane treatment in male rats.
The effect on testicular steroidogenesis after lindane (delta-isomer of hexachlorocyclohexane) administration of 4 and 8 mg/kg, i.p. daily for 45 days to male mature rats was investigated. A significant decline in testicular weight of both test groups was observed. Cellular degeneration in Leydig cells of the 8 mg/kg treated group was conspicuous. A sharp decline in the Leydig cell's population and morphological deformation were supported by the decreased activities of testicular hyaluronidase and 3 beta delta 5-hydroxysteroid dehydrogenase. A high level of testicular cholesterol and depletion of ascorbic acid were also responsible for steroidogenic impairment in the treated groups. These impairments also led to a significant diminution in serum testosterone.
Chowdhury
A R
AR
National Institute of Occupational Health, Meghani Nagar, Ahmedabad, India.
Gautam
A K
AK
D015096:3-Hydroxysteroid Dehydrogenases / Q000378:metabolism; D000818:Animals; D002452:Cell Count / Q000187:drug effects; D002784:Cholesterol / Q000378:metabolism*; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D006821:Hyaluronoglucosaminidase / Q000378:metabolism; D007985:Leydig Cells / Q000187:drug effects; D008297:Male; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011919:Rats, Inbred Strains; D013737:Testis / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D013739:Testosterone / Q000097:blood
D013739:Testosterone; D001556:Hexachlorocyclohexane; D002784:Cholesterol; D015096:3-Hydroxysteroid Dehydrogenases; D006821:Hyaluronoglucosaminidase