[The level of the eosinophils in the blood, serum immunoglobulins and circulating immune complexes and interferon production in patients with unilocular echinococcosis depending on the location of the cysts].
The correlations between blood eosinophils, serum immunoglobulins (Ig), circulating immune complexes (CIC) content, alpha- and gamma-interferon (IFN) production and HLA class I antigens were analyzed in 33 patients with hydatid disease aged 37.5 +/- 1.5 years. Direct correlation between the activity of gamma-IFN production, blood eosinophils, IgG and specific IgE content was found in patients with multiple pulmonary damage. In this group the high level of CIC correlated with the high content of IgG and specific IgE. In patients with solitary and multiple cysts in the liver in spite of high alpha- and gamma-IFN production the levels of total and specific IgE were low, IgG and CIC contents were moderate and eosinophils percent was low. In patients with combined damage of the liver and multiple cysts in the abdominal cavity high CIC production correlated directly with high total IgE content. In the total group of patients percent of HLA B5 carriers was significantly higher than in controls: 36.6 and 14.7 respectively (R = 0.01 after Fischer) that correlated with comparatively active gamma-IFN production in patients with the pulmonary and the liver cysts. The possible explanation of the different immune response in patients with the different localisation of the parasite cysts are discussed.
Ozeretskovskaia
N N
NN
Legon'kov
Iu A
IuA
Shcherbakov
A M
AM
Suntsov
S N
SN
Sabgaĭda
T P
TP
Grigorian
S S
SS
Gervazieva
V B
VB
D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D002648:Child; D004444:Echinococcosis, Hepatic / Q000097:blood* / Q000276:immunology; D004445:Echinococcosis, Pulmonary / Q000097:blood* / Q000276:immunology; D004804:Eosinophils / Q000166:cytology*; D005260:Female; D006680:HLA Antigens / Q000097:blood; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D007372:Interferons / Q000097:blood*; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged
D000936:Antigen-Antibody Complex; D006680:HLA Antigens; D007136:Immunoglobulins; D007372:Interferons