Successful treatment of neutropenia in the hyper-immunoglobulin M syndrome with granulocyte colony-stimulating factor.
METHODS
A young boy with hyper-immunoglobulin M (IgM) syndrome had recurrent severe infections, failure to thrive, and chronic neutropenia for 2 years despite treatment with i.v. gammaglobulin (IVIG).


RESULTS
With the addition of granulocyte colony-stimulating factor (G-CSF; Filgrastim, Amgen, Inc., Thousand Oaks, CA), increased doses of IVIG, and prophylactic trimethoprim-sulfamethoxazole, his absolute neutrophil count increased from 0.64 x 10(9)/L to 3.36 x 10(9)/L, and he has been free of significant infection for the past 22 months.


CONCLUSIONS
The use of G-CSF merits consideration in patients with hyper-IgM syndrome and severe neutropenia.
Wang
W C
WC
Department of Hematology/Oncology, St. Jude Children's Research Hospital, Memphis, Tennessee 38101.
Cordoba
J
J
Infante
A J
AJ
Conley
M E
ME
D002648:Child; D008040:Genetic Linkage; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D006942:Hypergammaglobulinemia / Q000097:blood / Q000150:complications / Q000628:therapy*; D007075:Immunoglobulin M / Q000097:blood*; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008297:Male; D009503:Neutropenia / Q000628:therapy*; D013577:Syndrome; D014960:X Chromosome
D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; D016179:Granulocyte Colony-Stimulating Factor