Defining rules for the peptide-MHC class II interaction.
Recent work has begun to clarify the molecular events governing peptide interaction with MHC class II proteins. The requirements for peptide binding to class I and class II molecules seem to be similar. Despite differences in peptide length, anchor residues defining allele-specific peptide motifs can also be found in class II binding peptides. The presence of conserved and allele-specific anchors appears to explain the promiscuity and the specificity of peptide recognition by DR molecules.
Sinigaglia
F
F
Roche Milano Ricerche, Milan, Italy.
Hammer
J
J
D000483:Alleles; D000595:Amino Acid Sequence; D000818:Animals; D000939:Epitopes; D000949:Histocompatibility Antigens Class II / Q000235:genetics / Q000276:immunology*; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry / Q000276:immunology*; D011485:Protein Binding
D000939:Epitopes; D000949:Histocompatibility Antigens Class II; D010455:Peptides