Vascular origin of Kaposi's sarcoma. Expression of leukocyte adhesion molecule-1, thrombomodulin, and tissue factor.
We studied seven cases of Kaposi's sarcomas (KS) obtained from patients with AIDS and one KS from a patient without HIV infection. Antigen expression was studied by immunocytochemistry and mRNA expression by in situ hybridisation. The markers tested were endothelial leukocyte adhesion molecule-1, thrombomodulin, and tissue factor. In all tumors (AIDS and non-AIDS associated) these markers reacted positive, indicating transcription and translation of these genes in KS. The synthesis and expression of tissue factor and thrombomodulin suggests that KS is a tumor that has tissue factor-mediated thrombin formation under the control of thrombomodulin. The expression of thrombomodulin and endothelial leukocyte adhesion molecule-1 provides evidence for the vascular origin of KS.
Zhang
Y M
YM
Department of Medicine, Pathology and Anatomy, University of Heidelberg, Germany.
Bachmann
S
S
Hemmer
C
C
van Lunzen
J
J
von Stemm
A
A
Kern
P
P
Dietrich
M
M
Ziegler
R
R
Waldherr
R
R
Nawroth
P P
PP
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001808:Blood Vessels / Q000502:physiology*; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D019040:E-Selectin; D006801:Humans; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D012514:Sarcoma, Kaposi / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D018180:Thrombomodulin / Q000378:metabolism*; D013925:Thromboplastin / Q000378:metabolism*
D015815:Cell Adhesion Molecules; D019040:E-Selectin; D018180:Thrombomodulin; D013925:Thromboplastin