title: Some desmoid tumors are characterized by trisomy 8.
abstract: Ten desmoid tumors were examined by chromosome banding analysis and by in situ hybridization on short-term cultures and frozen sections. Trisomy 8 was detected in four out of ten tumors, of which only one had shown trisomy 8 by karyotype analysis. Since trisomy 8 has been reported in superficial fibromatoses, which are clinically distinct but histologically similar to desmoid tumors, the occurrence of trisomy 8 in both may be a further indication of a close relationship.
authors.affiliation: Centre for Human Genetics, University of Leuven, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: R
authors.initials: R
authors.lastname: Sciot
authors.forename: M S
authors.initials: MS
authors.lastname: Aly
authors.forename: J
authors.initials: J
authors.lastname: Delabie
authors.forename: M
authors.initials: M
authors.lastname: Stas
authors.forename: I
authors.initials: I
authors.lastname: De Wever
authors.forename: B
authors.initials: B
authors.lastname: Van Damme
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000293:Adolescent; D000328:Adult; D002675:Child, Preschool; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8; D005260:Female; D018221:Fibromatosis, Abdominal / Q000235:genetics* / Q000473:pathology; D018222:Desmoid Tumors / Q000235:genetics* / Q000473:pathology; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014314:Trisomy; D014407:Tumor Cells, Cultured