Glucagonoma syndrome with increased lactate dehydrogenase isoenzymes: octreotide treatment.
Glucagonoma Syndrome is a rare syndrome comprising hyperglucagonemia, diabetes mellitus, necrolytic migratory erythema and hypoaminoacidemia in the setting of a glucagon producing, alpha cell tumour of the pancreas. We report a case of Glucagonoma Syndrome palliatively treated successfully with octreotide. In addition to classical clinical and biochemical findings, this patient also had a Glomus Jugulare tumour, and Empty Sella Syndrome and demonstrated an unusual pattern of plasma lactate dehydrogenase isoenzymes, features not previously reported in this syndrome.
Siller
G M
GM
Royal Brisbane Hospital.
Strutton
G M
GM
Moore
G A
GA
Kanowski
D M
DM
Nedwich
J A
JA
D004652:Empty Sella Syndrome / Q000150:complications; D005260:Female; D005925:Glomus Jugulare Tumor / Q000473:pathology; D005935:Glucagonoma / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D006801:Humans; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000473:pathology; D015282:Octreotide / Q000627:therapeutic use*; D010166:Palliative Care; D010190:Pancreatic Neoplasms / Q000150:complications / Q000188:drug therapy* / Q000201:enzymology / Q000473:pathology; D013577:Syndrome
D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D015282:Octreotide