title: Development of neutralizing and binding antibodies to interferon (IFN) in patients undergoing IFN therapy.
abstract: Since the 1970's, people started to use interferon as a therapeutic agent against infectious and neoplastic diseases. Since the beginning of its therapeutical use, it was demonstrated that some patients produce, when treated with interferon, antibodies able to neutralize its biological activity. This paper will review and discuss what it is currently known about the technical, biological, and clinical aspects of these antibodies.
authors.affiliation: Department of Biomedicine, University of Pisa, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Antonelli
mesh_terms: D006525:Hepatitis, Viral, Human / Q000188:drug therapy*; D006801:Humans; D007372:Interferons / Q000276:immunology* / Q000627:therapeutic use*; D009500:Neutralization Tests
chemical_list: D007372:Interferons