The Costello syndrome: report of a case and review of the literature.
A 5-year-old girl with the Costello syndrome is reported. Her clinical manifestations included growth and developmental delay, a distinct facial appearance with sparse and curly hair, nasal papillomata, and dark loose skin of the hands and feet. These manifestations, especially nasal papilloma, an age-dependent anomaly, are distinct in the Costello syndrome.
Kondo
I
I
Department of Hygiene, Ehime University School of Medicine, Japan.
Tamanaha
K
K
Ashimine
K
K
D000015:Abnormalities, Multiple / Q000235:genetics*; D002648:Child; D002658:Developmental Disabilities / Q000235:genetics*; D005145:Face / Q000002:abnormalities; D005260:Female; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D017880:Limb Deformities, Congenital; D009669:Nose Neoplasms / Q000235:genetics; D010212:Papilloma / Q000235:genetics; D012868:Skin Abnormalities; D013577:Syndrome