title: The influence of environmental factors on behavioural problems in 8-year-old children exposed to amphetamine during fetal life.
abstract: Sixty-five children born to women who all used amphetamine during pregnancy were followed prospectively up to the age of 8 years. There was a statistically significant correlation between the extent (among and duration) of amphetamine exposure during fetal life and psychometric tests, aggressive behavior, adjustment and general assessment, indicating a worse outcome for children who had been more exposed to the drug. Alcohol use during pregnancy as well as attitude towards pregnancy also showed a statistical correlation to the outcome. Predictors of the child's psychosocial environment were few and only maternal psychiatric treatment, alcohol abuse and number of custodians correlated with aggressive behavior and general assessment.
authors.affiliation: Department of Pediatrics, Karolinska Institute, St. Göran's Children's Hospital, Stockholm, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Billing
authors.forename: M
authors.initials: M
authors.lastname: Eriksson
authors.forename: B
authors.initials: B
authors.lastname: Jonsson
authors.forename: G
authors.initials: G
authors.lastname: Steneroth
authors.forename: R
authors.initials: R
authors.lastname: Zetterström
mesh_terms: D000437:Alcoholism; D000662:Amphetamines / Q000009:adverse effects*; D002648:Child; D002653:Child Behavior Disorders / Q000175:diagnosis* / Q000209:etiology; D002669:Child Welfare; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000175:diagnosis / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008425:Maternal Behavior; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D002666:Psychology, Child; D012737:Sex Factors; D019966:Substance-Related Disorders
chemical_list: D000662:Amphetamines