Larsen syndrome in siblings with consanguineous parents.
Two siblings with Larsen syndrome and consanguineous parents are described, both with multiple joint dislocations and the typical facial appearance. Short stature is marked in both children and one had a diaphragmatic hernia which has not been previously described in this condition.
Topley
J M
JM
Department of Paediatrics, College of Medicine, Blantyre, Malawi.
Varady
E
E
Lestringant
G G
GG
D000015:Abnormalities, Multiple / Q000235:genetics*; D003241:Consanguinity; D002658:Developmental Disabilities / Q000235:genetics; D005145:Face / Q000002:abnormalities*; D005260:Female; D005500:Follow-Up Studies; D006130:Growth Disorders / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn; D007596:Joints / Q000002:abnormalities*; D008297:Male; D013577:Syndrome