title: Cardiovascular effects of moderate normovolaemic haemodilution during enflurane-nitrous oxide anaesthesia in man.
abstract: The cardiovascular effects of mild normovolaemic haemodilution during enflurane-nitrous oxide anaesthesia were studied in 20 patients with normal cardiac function before, during and after total hip replacement. After induction of anaesthesia, patients were randomly allocated to one control group (C), or one haemodiluted group (H) where Hct was decreased to 30% by replacement of blood volume by an identical volume of hydroxyethyl starch 200/05. Each patient was monitored with a pulmonary artery catheter allowing the measurement of right ventricular ejection fraction. During haemodilution, stroke index and right ventricular end-diastolic volume index increased from 33.1 +/- 7.9 to 39.3 +/- 7.1 ml.M-2 and from 73.8 +/- 20.3 to 94.9 +/- 18.5 ml.M-2 respectively (mean +/- s.d., both P < 0.05). However, heart rate decreased so that cardiac index did not change. O2 delivery decreased significantly (from 389 +/- 70 to 311 +/- 63 ml.min-1.m-2; P < 0.05), but was not different to the control group. O2 consumption was maintained by an increase in O2 extraction. During the surgical procedure, cardiac index was higher in the haemodiluted group than in the control group, so that O2 delivery was similar in the two groups. O2 consumption tended to be greater in the haemodiluted group. In patients with normal cardiac function, enflurane-nitrous oxide anesthesia could alter the normal physiologic response to mild normovolaemic haemodilution.
authors.affiliation: Department of Anaesthesiology, Erasme University Hospital, Free University of Brussels, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Van der Linden
authors.forename: M
authors.initials: M
authors.lastname: Wathieu
authors.forename: E
authors.initials: E
authors.lastname: Gilbart
authors.forename: E
authors.initials: E
authors.lastname: Engelman
authors.forename: J C
authors.initials: JC
authors.lastname: Wautrecht
authors.forename: A
authors.initials: A
authors.lastname: Lenaers
authors.forename: J L
authors.initials: JL
authors.lastname: Vincent
mesh_terms: D000769:Anesthesia, Inhalation; D001794:Blood Pressure / Q000187:drug effects; D001810:Blood Volume; D002302:Cardiac Output / Q000187:drug effects; D004737:Enflurane / Q000494:pharmacology*; D005260:Female; D006321:Heart / Q000187:drug effects*; D006400:Hematocrit; D006438:Hemodilution / Q000379:methods; D006622:Hip Prosthesis; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009609:Nitrous Oxide / Q000494:pharmacology*; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption / Q000187:drug effects; D013318:Stroke Volume / Q000187:drug effects; D014655:Vascular Resistance / Q000187:drug effects; D016277:Ventricular Function, Left / Q000187:drug effects; D016278:Ventricular Function, Right / Q000187:drug effects
chemical_list: D006895:Hydroxyethyl Starch Derivatives; D004737:Enflurane; D009609:Nitrous Oxide; D010100:Oxygen