[Effect of autoinducers of anabiosis for some microorganisms on rat liver mitochondria respiration].
2-(4-Hydroxyphenyl)ethane-1-ol (tyrosol) and 5-n-alkyl(C19,C21)resorcinols produced by some microorganisms as anabiosis autoregulators (factors d1) inhibit the electron transport and uncouple oxidative phosphorylation in the respiratory chain of rat liver mitochondria: a 50% decrease of the respiratory control is caused by 0.32-0.36 mumol of tyrosol or by 0.21-0.26 mumol of alkylresorcinols per mg of protein. Alkylresorcinols reduce the NADH-dehydrogenase and succinate dehydrogenase activities in mitochondria, whereas tyrosol acts predominantly on the NADH-dehydrogenase activity.
Nenashev
V A
VA
Pridachina
N N
NN
El'-Registran
G I
GI
Zolotareva
I N
IN
Batrakov
S G
SG
D000818:Animals; D004579:Electron Transport / Q000187:drug effects; D008930:Mitochondria, Liver / Q000201:enzymology / Q000378:metabolism*; D009245:NADH Dehydrogenase / Q000378:metabolism; D010626:Phenylethyl Alcohol / Q000031:analogs & derivatives* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012118:Resorcinols / Q000494:pharmacology*; D012441:Saccharomyces cerevisiae / Q000737:chemistry* / Q000502:physiology; D013385:Succinate Dehydrogenase / Q000378:metabolism
D012118:Resorcinols; C011867:4-hydroxyphenylethanol; D013385:Succinate Dehydrogenase; D009245:NADH Dehydrogenase; D010626:Phenylethyl Alcohol