Inhibition of pancreatic exocrine secretion by galanin.
The influence of extrapancreatic nerves on the inhibition of meal- and secretogogue-induced pancreatic secretion by galanin was studied in conscious dogs. Chronic pancreatic fistulae were created in five mongrel dogs and a second group of five dogs also underwent complete pancreatic denervation. After recovery, galanin dose response (150-1,200 pmol/kg/h) revealed that 600 pmol/kg/h was the lowest dose of galanin to significantly inhibit pancreatic exocrine secretion. Pancreatic responses to a mixed meal, cholecystokinin (CCK) dose response (12.5-200 ng/kg/h), and secretin dose response (16-500 ng/kg/h) were determined. The experiments were then replicated with a continuous background infusion of galanin (600 pmol/kg/h). Galanin inhibited meal-, CCK-, and secretin-induced bicarbonate outputs in both the innervated and denervated pancreas. Galanin also inhibited meal- and CCK-induced protein responses in both groups. We conclude that extrapancreatic nerves do not mediate the inhibitory effects of galanin.
Brodish
R J
RJ
Department of Surgery, University of Cincinnati Medical Center, Ohio.
Kuvshinoff
B W
BW
Fink
A S
AS
McFadden
D W
DW
D000818:Animals; D001639:Bicarbonates / Q000378:metabolism; D002766:Cholecystokinin / Q000494:pharmacology; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D019004:Galanin; D009479:Neuropeptides / Q000494:pharmacology*; D010179:Pancreas / Q000187:drug effects* / Q000294:innervation / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D011506:Proteins / Q000378:metabolism
D001639:Bicarbonates; D009479:Neuropeptides; D010455:Peptides; D011506:Proteins; D019004:Galanin; D002766:Cholecystokinin