Effect of steroid eluting versus conventional electrodes on propafenone induced rise in chronic ventricular pacing threshold.
The aim of this study was to evaluate chronic ventricular pacing threshold increase after oral propafenone therapy. Eighty-three patients affected by advanced atrioventricular block and sick sinus syndrome were studied at least 3 months after pacemaker implantation, before and after oral propafenone therapy (450-900 mg/day based on body weight). The patients were subdivided into three groups according to the type of unipolar electrode that was implanted: group I (41 patients) Medtronic CapSure 4003, group II (30 patients) Medtronic Target Tip 4011, and group III (12 patients) Osypka Vy screw-in lead. In all cases a Medtronic unipolar pacemaker was implanted: 30 Minix, 23 Activitrax, 14 Elite, 12 Legend, and 4 Pasys. Propafenone blood level was measured in 75 patients 3-5 hours after propafenone administration. The pacing autothreshold was measured at 0.8 V, 1.6 V, and 2.5 V by reducing pulse width. At the three different outputs before and after propafenone, threshold increments were significantly lower in group I in comparison with group II and group III (propafenone ranging from < 0.001 to < 0.05). No significant difference was found in pacing impedance or in propafenone plasma concentration in the three groups. Strength-duration curves were drawn for each group at baseline and after propafenone administration. Before propafenone, in group I, the knee was markedly shifted to the left and downward as compared to the classic curve, so that the steep part was predominant; in group II and group III this shift was progressively less evident.(ABSTRACT TRUNCATED AT 250 WORDS)
Cornacchia
D
D
Department of Cardiology, Ospedale per gli Infermi, Faenza, Italy.
Fabbri
M
M
Maresta
A
A
Nigro
P
P
Sorrentino
F
F
Puglisi
A
A
Ricci
R
R
Peraldo
C
C
Fazzari
M
M
Pistis
G
G
D000368:Aged; D002304:Cardiac Pacing, Artificial; D003131:Combined Modality Therapy; D004562:Electrocardiography; D004567:Electrodes, Implanted; D005260:Female; D006327:Heart Block / Q000628:therapy; D006352:Heart Ventricles / Q000503:physiopathology; D006801:Humans; D008297:Male; D010138:Pacemaker, Artificial; D011405:Propafenone / Q000008:administration & dosage* / Q000493:pharmacokinetics; D012804:Sick Sinus Syndrome / Q000628:therapy; D013256:Steroids / Q000008:administration & dosage*
D013256:Steroids; D011405:Propafenone