title: Improved outcome of systemic lupus erythematosus among children in Durban, South Africa.
abstract: As systemic lupus erythematosus (SLE) is an uncommon disorder of childhood and is rarely seen among children in developing countries, management is not based on secure criteria and is often a matter of individual preference. In our previous experience, all four children suffering from SLE died soon after diagnosis. Aggressive therapy has been recommended to deal with such problems in the third world. We now report improved management of four more children with SLE seen since 1988 at King Edward VIII Hospital and observed for from 21 to 57 months. All our patients had evidence of renal involvement, with severe disease in two patients confirmed on renal biopsy; three had neurological involvement. The mainstay of treatment was a combination of steroids, azathioprine and chloroquine together with pulse methylprednisolone or cyclophosphamide for severe relapses. Disease activity was closely monitored, using clinical and laboratory criteria. Following therapy, all patients are in a stable condition and in clinical remission; one has mild renal impairment. These early results suggest that the judicious use of a few drugs, together with regular and meticulous follow-up, can greatly improve the prognosis of childhood SLE, even in third world countries.
authors.affiliation: Department of Paediatrics, King Edward VIII Hospital, Durban, South Africa.
authors.forename: R
authors.initials: R
authors.lastname: Bhimma
authors.forename: H M
authors.initials: HM
authors.lastname: Coovadia
authors.forename: M
authors.initials: M
authors.lastname: Adhikari
mesh_terms: D001379:Azathioprine / Q000627:therapeutic use; D002648:Child; D002738:Chloroquine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000188:drug therapy*; D008297:Male; D011379:Prognosis; D012074:Remission Induction; D013019:South Africa; D013256:Steroids / Q000627:therapeutic use*
chemical_list: D013256:Steroids; D002738:Chloroquine; D001379:Azathioprine