title: Management of pineal non-germinoma germ cell tumor with residual teratoma and normal alpha-fetoprotein.
abstract: A 16-year-old white male presented with multiple abnormal extraocular movements secondary to an enhancing pineal tumor. Subtotal resection of the lesion revealed a mixed malignant germ cell tumor. The preoperative serum alpha-fetoprotein (AFP) was markedly elevated at 155 IU/L. The patient subsequently received radiotherapy and adjuvant chemotherapy consisting of cisplatin rotating monthly with vincristine and cyclophosphamide, with dramatic tumor regression and return of AFP to normal. Eighteen months later the persistence of a substantial tumor mass despite a normal AFP raised concern for residual active tumor. Histological examination of the resected lesion revealed benign teratoma and fibrous tissue. Repeat management of mixed malignant germ cell tumors, which demonstrate a persistent mass following an initial response to treatment.
authors.affiliation: Department of Surgery (Neurosurgery), Duke University Medical Center, Durham, North Carolina 27710.
authors.forename: J R
authors.initials: JR
authors.lastname: Nashold
authors.forename: W J
authors.initials: WJ
authors.lastname: Oakes
authors.forename: H S
authors.initials: HS
authors.lastname: Friedman
authors.forename: E C
authors.initials: EC
authors.lastname: Halperin
authors.forename: M
authors.initials: M
authors.lastname: Soo
authors.forename: B
authors.initials: B
authors.lastname: Hockenberger
authors.forename: G N
authors.initials: GN
authors.lastname: Fuller
authors.forename: R
authors.initials: R
authors.lastname: Tien
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000175:diagnosis / Q000628:therapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D003520:Cyclophosphamide / Q000008:administration & dosage; D018237:Germinoma / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D008297:Male; D010870:Pineal Gland; D012086:Reoperation; D013724:Teratoma / Q000175:diagnosis; D014750:Vincristine / Q000008:administration & dosage; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D000509:alpha-Fetoproteins; D014750:Vincristine; D003520:Cyclophosphamide; D002945:Cisplatin