Catecholaminergic projections from the solitary tract nucleus to the perifornical hypothalamus.
The source of adrenergic and other catecholaminergic fibers innervating the perifornical lateral hypothalamus was localized in the medulla after combination of Fluoro-Gold retrograde tracing and immunohistochemistry for either tyrosine-hydroxylase or phenylethanolamine-N-methyltransferase. Following perifornical injections, Fluoro-Gold-labeled neurons were observed mainly in regions including the noradrenergic and adrenergic cell groups. In the caudal solitary tract nucleus, two kinds of doubly labeled neurons were found: a) numerous noradrenergic neurons in the A2 group at the level of, or caudal to the area postrema; b) some adrenergic neurons in the C2 group at a level immediately rostral to the area postrema. These catecholaminergic neurons connecting the caudal solitary tract nucleus to the perifornical hypothalamus might convey feeding relevant information such as glycemic level or satiety signals.
Pierret
P
P
Laboratoire de Neurobiologie, CNRS, Université de Provence, Marseille, France.
Christolomme
A
A
Bosler
O
O
Perrin
J
J
Orsini
J C
JC
D000818:Animals; D001370:Axonal Transport; D015415:Biomarkers / Q000032:analysis; D005456:Fluorescent Dyes; D007026:Hypothalamic Area, Lateral / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D008526:Medulla Oblongata / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D010625:Phenylethanolamine N-Methyltransferase / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D017552:Solitary Nucleus / Q000033:anatomy & histology / Q000166:cytology / Q000502:physiology*; D013266:Stilbamidines; D014446:Tyrosine 3-Monooxygenase / Q000032:analysis
C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D015415:Biomarkers; D005456:Fluorescent Dyes; D013266:Stilbamidines; D014446:Tyrosine 3-Monooxygenase; D010625:Phenylethanolamine N-Methyltransferase