Serotonin level and turnover rate in brown adipose tissue of developing rats.
The level and turnover rate (TR) of serotonin (5-HT) were determined in the brown adipose tissue (BAT) of rats born and reared at 28 degrees C and 16 degrees C. The serotonin/norepinephrine ratio was high in BAT of both groups for the first 2 days. Thereafter it fell. During the first 3 days, the TR was three times higher in 16 degrees C rats than in 28 degrees C rats. A similar difference was observed for the 5-HIAA/5-HT ratio during that period. It is concluded that 5-HT may act on BAT thermogenesis in cold-exposed pups but its mechanism of action is still hypothetical.
Bertin
R
R
Laboratoire d'Adaptation Energétique à l'Environnement, Ecole Pratique des Hautes Etudes, Paris, France.
Mouroux
I
I
De Marco
F
F
Portet
R
R
D002001:Adipose Tissue, Brown / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005333:Fetus / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007700:Kinetics; D008297:Male; D009638:Norepinephrine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D013696:Temperature
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D009638:Norepinephrine