title: [The effect of IL-1 receptor antagonist on bleomycin-induced pulmonary fibrosis].
abstract: Interleukin-1 (IL-1) is a cytokine with diverse biological activities. It can serve as a fibroblast (FB) growth factor which involves in the development of pulmonary fibrosis. IL-1 receptor antagonist (IL-1ra) can compete with IL-1 for occupancy of surface receptors of target cells without agonist effect. In order to find a new method to treat pulmonary fibrosis, we investigated the effect of recombinant human IL-1ra on the development of pulmonary fibrosis by evaluating collagen content, histological change, and TGF-beta mRNA expression in the rats bleomycin-induced pulmonary fibrosis. The results indicate are that there are no significant difference between the IL-1ra treated group and the control group.
authors.affiliation: First Teaching Hospital, Beijing Medical University.
authors.forename: B
authors.initials: B
authors.lastname: He
authors.forename: G R
authors.initials: GR
authors.lastname: Zhao
authors.forename: X M
authors.initials: XM
authors.lastname: Liu
mesh_terms: D000818:Animals; D001761:Bleomycin; D053590:Interleukin 1 Receptor Antagonist Protein; D008297:Male; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000628:therapy*; D051381:Rats; D017208:Rats, Wistar; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D011994:Recombinant Proteins / Q000627:therapeutic use; D012795:Sialoglycoproteins / Q000627:therapeutic use*
chemical_list: C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D011994:Recombinant Proteins; D012795:Sialoglycoproteins; D001761:Bleomycin