Intercrines in brain pathology. Expression of intercrines in a multiple sclerosis and Morbus Creutzfeldt-Jakob lesion.
Expression of cytokine genes regulating vascular permeability and chemoattraction was studies by polymerase chain reaction in RNA from two different types of brain lesions: a multiple sclerosis plaque and in tissue from a patient with Creutzfeldt-Jakob disease. While cytokine genes encoding vascular permeability factor, interleukin (IL)-2, IL-4, or IL-10, generally associated with active inflammatory processes, were not expressed, we observed expression of some intercrine genes in both types of lesions. As these lesions share a common set of structural features such as prominent astrogliosis and glial cells are known producers of intercrines, we suggest that intercrines have a role in the formation of gliotic brain lesions.
Schluesener
H J
HJ
Institut für Hirnforschung, Eberhard-Karls Universität Tübingen, Germany.
Meyermann
R
R
D000368:Aged; D001921:Brain / Q000378:metabolism / Q000473:pathology*; D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics / Q000473:pathology*; D016207:Cytokines / Q000096:biosynthesis* / Q000235:genetics; D004587:Electrophoresis, Agar Gel; D005260:Female; D005786:Gene Expression Regulation; D006801:Humans; D007378:Interleukins / Q000096:biosynthesis / Q000235:genetics; D008297:Male; D009103:Multiple Sclerosis / Q000235:genetics / Q000473:pathology*; D016133:Polymerase Chain Reaction; D012313:RNA / Q000302:isolation & purification
D016207:Cytokines; D007378:Interleukins; D012313:RNA