Chemosensitivity of C-cells in bullfrog dorsal root ganglia to substance P and adenosine 5'-triphosphate.
Dissociated bullfrog dorsal root ganglion cells were voltage clamped in the whole-cell configuration. In small C-cells having 20 microns as averaged diameter, substance-P (0.1-1 microM) inhibited an M-type potassium current while ATP (1-10 microM) activated a sodium-potassium current. In large A-cells (approximately 65 microns in diameter) in which ATP has been shown to inhibit M-current, substance P (0.1-1 microM) also inhibited this potassium current without activating the sodium-potassium current. Results provided evidence for the distinction between A- and C-cells in terms of their chemosensitivity.
Tokimasa
T
T
Department of Physiology, Kurume University School of Medicine, Japan.
Tsurusaki
M
M
Akasu
T
T
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D004553:Electric Conductivity; D005071:Evoked Potentials / Q000187:drug effects; D005727:Ganglia, Spinal / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D066298:In Vitro Techniques; D009474:Neurons / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D011892:Rana catesbeiana; D013373:Substance P / Q000494:pharmacology*
D015220:Calcium Channels; D013373:Substance P; D000255:Adenosine Triphosphate