Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition.
Heitman
J
J
Department of Genetics, Howard Hughes Medical Institute, Duke University Center, Durham, NC 27710.
Cardenas
M E
ME
Breuder
T
T
Hemenway
C
C
Muir
R S
RS
Lim
E
E
Goetz
L
L
Zhu
D
D
Lorenz
M
M
Dolinski
K
K
D000591:Amino Acid Isomerases / Q000096:biosynthesis / Q000235:genetics; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D002352:Carrier Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D016572:Cyclosporine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006360:Heat-Shock Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D008322:Mammals; D008954:Models, Biological; D016296:Mutagenesis; D019696:Peptidylprolyl Isomerase; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D016559:Tacrolimus / Q000494:pharmacology*; D022021:Tacrolimus Binding Proteins
D000935:Antifungal Agents; D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D006360:Heat-Shock Proteins; D016572:Cyclosporine; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases; D000591:Amino Acid Isomerases; D022021:Tacrolimus Binding Proteins; D019696:Peptidylprolyl Isomerase; D016559:Tacrolimus