[Met-enkephalin and substance P. Comparison of CSF levels in patients with chronic pain based on a sampling procedure].
The purpose of this study was to evaluate the Met-enkephalin and the SP-like immunoreactivity levels in the CSF of 16 patients suffering from chronic sciatalgia and to compare them with those of 8 control subjects. Eight of the patients had a ventriculo-peritoneal shunt which made it possible to collect samples of CSF painlessly. For the others patients and controls, CSF samples were collected by lumbar puncture. The results showed that there was no difference in the Met-enkephalin and SP levels whatever the method of sample collection. On the other hand, SP-like immunoreactivity was lower in patients suffering from chronic pain.
Guieu
R
R
Laboratoire de Biochimie, Faculté de Médecine, secteur Nord, Université de Provence, Marseille.
Tardy-Gervet
M F
MF
Giraud
P
P
Boudouresque
F
F
D000328:Adult; D000368:Aged; D002908:Chronic Disease; D004744:Enkephalin, Methionine / Q000134:cerebrospinal fluid*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010146:Pain / Q000134:cerebrospinal fluid*; D012494:Sampling Studies; D013129:Spinal Puncture; D013373:Substance P / Q000134:cerebrospinal fluid*; D017287:Ventriculoperitoneal Shunt
D013373:Substance P; D004744:Enkephalin, Methionine