title: Haemorrhagic-ischaemic lesions of the neonatal brain: correlation between cerebral visual impairment, neurodevelopmental outcome and MRI in infancy.
abstract: The relationship between the degree of cerebral visual impairment, established using the acuity card procedure, and the extent of neurological sequelae was assessed in 65 at-risk neonates in a prospective follow-up study. MRI and CT scans were performed in all infants with severe neurological sequelae. 11 of 12 children with an acuity at or below the 10th centile at 18 months developed cerebral palsy: the underlying condition was extensive cystic leukomalacia in all. An acuity above the 10th centile was no guarantee of normal development, as 10 out of 52 such infants developed cerebral palsy. MRI and CT scans showed that periventricular high signal intensity in the occipital area was a non-specific finding with regard to visual function. Extensive periventricular white matter loss and involvement of the striate/parastriate cortex was found in the most severely visually impaired infants.
authors.affiliation: Department of Child Neurology, Whilhelmina Children's Hospital, Utrecht, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Eken
authors.forename: L S
authors.initials: LS
authors.lastname: de Vries
authors.forename: Y
authors.initials: Y
authors.lastname: van der Graaf
authors.forename: L C
authors.initials: LC
authors.lastname: Meiners
authors.forename: O
authors.initials: O
authors.lastname: van Nieuwenhuizen
mesh_terms: D002545:Brain Ischemia / Q000145:classification / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D016022:Case-Control Studies; D002543:Cerebral Hemorrhage / Q000145:classification / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D002658:Developmental Disabilities / Q000453:epidemiology / Q000209:etiology*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D007969:Leukomalacia, Periventricular / Q000145:classification / Q000150:complications* / Q000175:diagnosis / Q000453:epidemiology; D008279:Magnetic Resonance Imaging; D008297:Male; D011379:Prognosis; D011446:Prospective Studies; D012720:Severity of Illness Index; D014057:Tomography, X-Ray Computed; D017585:Ultrasonography, Doppler, Transcranial; D014786:Vision Disorders / Q000145:classification / Q000175:diagnosis / Q000453:epidemiology / Q000209:etiology*; D014792:Visual Acuity