title: The influence of ovarian follicular activity on late proliferative phase serum IGFBP-1 in down-regulated assisted conception cycles.
abstract: Serum insulin-like growth factor binding protein-1 (IGFBP-1) concentrations were measured at the end of the proliferative phase in infertility patients undergoing normal menstrual cycle frozen embryo transfer, exogenous hormone-supported frozen embryo transfer and in-vitro fertilization (IVF) treatment cycles. These patients were divided into five groups according to their ovarian follicular activity. The exogenous hormone-supported frozen embryo transfer group, who had no ovarian follicles, and the IVF groups (number of follicles ranging from 4-38) showed statistically higher serum IGFBP-1 concentrations when compared to the normal menstrual cycle group (P < or = 0.01). There was no significant difference in the serum IGFBP-1 concentrations between the exogenous hormone support frozen embryo transfer group and the poor or normal response IVF groups (number of follicles ranging from 4 to 16). An IVF group that displayed an excessive response to our standard human menopausal gonadotrophin stimulation (> 20 mature follicles or oestradiol > 10,000 pmol/l) showed a significantly higher serum IGFBP-1 concentration when compared with the other groups (P = 0.001). This subgroup was subsequently given a modified (follicle-stimulating hormone) stimulation regime which resulted in a significant reduction in serum IGFBP-1 concentrations (P < 0.05). There was no correlation between serum oestradiol and IGFBP-1 overall or within the patient groups. We conclude that serum IGFBP-1 concentrations in our down-regulated assisted conception cycles did not increase in line with ovarian follicular activity, unless an excessive response was displayed.
authors.affiliation: Department of Obstetrics and Gynaecology, Princess Anne Hospital, Southampton, Hampshire, UK.
authors.forename: I D
authors.initials: ID
authors.lastname: Arthur
authors.forename: F W
authors.initials: FW
authors.lastname: Anthony
authors.forename: G M
authors.initials: GM
authors.lastname: Masson
authors.forename: E J
authors.initials: EJ
authors.lastname: Thomas
mesh_terms: D000328:Adult; D002352:Carrier Proteins / Q000097:blood*; D015925:Cryopreservation; D004624:Embryo Transfer; D004958:Estradiol / Q000097:blood; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007247:Infertility, Female / Q000628:therapy; D018970:Insulin-Like Growth Factor Binding Protein 1; D007986:Luteinizing Hormone / Q000008:administration & dosage / Q000627:therapeutic use; D008596:Menotropins / Q000627:therapeutic use; D008597:Menstrual Cycle; D006080:Ovarian Follicle / Q000502:physiology*; D011247:Pregnancy
chemical_list: D002352:Carrier Proteins; D018970:Insulin-Like Growth Factor Binding Protein 1; D004958:Estradiol; D008596:Menotropins; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone