Oral terbutaline in the outpatient management of preterm labor.
OBJECTIVE
Our purpose was to prove our hypothesis that once preterm uterine contractions and/or labor is controlled with intravenous tocolysis, oral terbutaline, as a maintenance drug, does not prolong pregnancy.


METHODS
Before discharge, 184 patients between 24 and 35 completed weeks' gestation were prospectively randomized to continued bed rest either with or without oral terbutaline. Assignment was made with stratification into four groups: group 1, those patients with a Bishop score > or = 5 with oral terbutaline (n = 50); group 2, those with a Bishop score > or = 5 without oral terbutaline (n = 53); group 3, those with a Bishop score < 5 with oral terbutaline (n = 41); group 4, those with a Bishop score < 5 without oral terbutaline (n = 40). Oral terbutaline was discontinued at 37 completed weeks.


RESULTS
No statistically significant differences were found in the number of readmissions, the number of unscheduled hospital visits, and the neonatal outcomes among the four groups. The gestational age at delivery and percent of deliveries at > or = 37 weeks were not significantly different when group 1 was compared with group 2 and group 3 was compared with group 4.


CONCLUSIONS
Oral terbutaline maintenance does not improve pregnancy outcome in patients who have had initial successful intravenous tocolysis.
How
H Y
HY
Department of Obstetrics and Gynecology, University of Louisville School of Medicine, USA.
Hughes
S A
SA
Vogel
R L
RL
Gall
S A
SA
Spinnato
J A
JA
D000284:Administration, Oral; D000328:Adult; D001510:Bed Rest; D001724:Birth Weight; D002585:Cesarean Section; D036861:Delivery, Obstetric; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D007232:Infant, Newborn, Diseases / Q000453:epidemiology; D007902:Length of Stay; D009017:Morbidity; D007752:Obstetric Labor, Premature / Q000517:prevention & control*; D010045:Outpatients; D011247:Pregnancy; D013726:Terbutaline / Q000008:administration & dosage / Q000627:therapeutic use*
D013726:Terbutaline