Inhibition of Semliki Forest virus multiplication in L-cells by combinations of interferon and ribavirin as measured by plaque titration and direct enzyme immunoassay.
Inhibition of Semliki Forest virus (SFV) multiplication in L-cell monolayers by combinations of mouse interferon (IFN) and ribavirin was measured by plaque titration and by direct enzyme immunoassay of SFV in L-cells. When critically inhibitory quantities of IFN and ribavirin were combined, an additive inhibitory effect was observed in either assay.
Harmsen
T
T
Eijkman-Winkler Laboratory for Medical Microbiology, Utrecht University, The Netherlands.
Van Veenendaal
D
D
Kraaijeveld
C A
CA
D000818:Animals; D004357:Drug Synergism; D007124:Immunoenzyme Techniques; D007372:Interferons / Q000494:pharmacology*; D007739:L Cells; D051379:Mice; D012254:Ribavirin / Q000494:pharmacology*; D012672:Semliki forest virus / Q000254:growth & development*; D010948:Viral Plaque Assay; D014779:Virus Replication / Q000187:drug effects
D012254:Ribavirin; D007372:Interferons