[The reversibility of a blockade of corticofugal pulse trains to the neurons of the caudate nucleus in cats evoked by the neurotoxin MPTP].
In anesthetised cats, the number of the caudate nucleus neurons responding to a cortical stimulation with latency less than 8.0 ms, increased within 10-12 days after the MPTP administration and then gradually recovers by the 45th-54th day after the neurotoxin administration. Dopamine seems to exert a protecting-inhibiting effect on transmission of corticofugal glutamatergic impulses travelling towards the neostriatum neurons.
Oleshko
N N
NN
D000200:Action Potentials / Q000187:drug effects / Q000502:physiology; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects* / Q000502:physiology; D018492:Dopamine Antagonists / Q000633:toxicity*; D004558:Electric Stimulation; D020267:MPTP Poisoning; D008297:Male; D008839:Microelectrodes; D009044:Motor Cortex / Q000187:drug effects* / Q000502:physiology; D009433:Neural Inhibition / Q000187:drug effects* / Q000502:physiology; D009474:Neurons / Q000187:drug effects* / Q000502:physiology; D011930:Reaction Time / Q000187:drug effects / Q000502:physiology; D013997:Time Factors
D018492:Dopamine Antagonists; D001058:Apomorphine