title: Spinal co-administration of peptide substance P antagonist increases antinociceptive effect of the opioid peptide biphalin.
abstract: Intrathecal injection of 0.25 micrograms of undecapeptide substance P antagonist (SPA) produced transient antinociception with a peak effect at 5 min. Increasing the SPA dose resulted in neurotoxicity. Intrathecal injection of the opioid peptide biphalin (BIP) produced antinociception for over 3 hrs without neurotoxicity. Co-administration of SPA (at subtoxic doses) increased BIP's antinociceptive effect. Naltrexone reversed analgesia due to BIP alone as well as after BIP+SPA.
authors.affiliation: Department of Pharmacodynamics, Medical Academy, Warsaw, Poland.
authors.forename: K
authors.initials: K
authors.lastname: Misterek
authors.forename: I
authors.initials: I
authors.lastname: Maszczynska
authors.forename: A
authors.initials: A
authors.lastname: Dorociak
authors.forename: S W
authors.initials: SW
authors.lastname: Gumulka
authors.forename: D B
authors.initials: DB
authors.lastname: Carr
authors.forename: S K
authors.initials: SK
authors.lastname: Szyfelbein
authors.forename: A W
authors.initials: AW
authors.lastname: Lipkowski
mesh_terms: D000700:Analgesics / Q000008:administration & dosage* / Q000494:pharmacology; D000818:Animals; D004357:Drug Synergism; D004745:Enkephalins / Q000008:administration & dosage* / Q000494:pharmacology; D007278:Injections, Spinal; D008297:Male; D009271:Naltrexone / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy*; D010147:Pain Measurement; D051381:Rats; D017208:Rats, Wistar; D013373:Substance P / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000037:antagonists & inhibitors / Q000494:pharmacology
chemical_list: D000700:Analgesics; D004745:Enkephalins; D013373:Substance P; D009271:Naltrexone; C032132:substance P, prolyl(2)-tryptophan(7,9)-; C053673:biphalin