title: What makes an mRNA anti-sense-itive?
abstract: Antisense RNA has been used for some time as a versatile tool for silencing gene expression. There is ample evidence for gene regulation by endogenous antisense transcripts in prokaryotes and increasing insight into the molecular mechanisms underlying such regulation. The introduction of antisense gene constructs into eukaryotes has now become routine but the mechanisms by which gene expression is inhibited are barely understood. In recent years, several examples of endogenous eukaryotic antisense transcripts have been discovered, some of which probably serve regulatory functions. Here we will discuss a model to explain mechanisms of antisense-mediated gene silencing.
authors.affiliation: Max-Planck-Institut für Biochemie, Martinsried, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Nellen
authors.forename: C
authors.initials: C
authors.lastname: Lichtenstein
mesh_terms: D000818:Animals; D015870:Gene Expression; D006801:Humans; D051379:Mice; D009693:Nucleic Acid Hybridization / Q000235:genetics; D012313:RNA / Q000235:genetics; D020365:RNA Helicases; D012316:RNA Nucleotidyltransferases / Q000235:genetics; D016372:RNA, Antisense; D012330:RNA, Double-Stranded / Q000235:genetics; D012333:RNA, Messenger
chemical_list: D016372:RNA, Antisense; D012330:RNA, Double-Stranded; D012333:RNA, Messenger; D012313:RNA; D012316:RNA Nucleotidyltransferases; D020365:RNA Helicases