title: [Ocular involvement in Whipple disease].
abstract: PATIENTS AND METHODS We present a 57-year-old white man with progressive deterioration of vision, who had a prolonged history of weakness, migratory arthralgias and loss of weight. Bilateral panuveitis, with iritis, inflammatory vitreous opacities associated with small, round, grayish retinal lesions. The duodenum showed a swollen mucosa, which was flecked over with pinpoint grayish grains. A small-bowel biopsy disclosed PAS-positive granules in the macrophages of the lamina propria mucosa, pathognomonic of Whipple's disease. RESULTS After antibiotic treatment with trimethoprim and sulfamethoxazole there was no relapse of the panuveitis during the follow-up period of 18 months.
authors.affiliation: Augenklinik der Universität Essen.
authors.forename: M
authors.initials: M
authors.lastname: Schrenk
authors.forename: K
authors.initials: K
authors.lastname: Metz
authors.forename: A
authors.initials: A
authors.lastname: Heiligenhaus
authors.forename: P
authors.initials: P
authors.lastname: Layer
authors.forename: N
authors.initials: N
authors.lastname: Bornfeld
authors.forename: A
authors.initials: A
authors.lastname: Wessing
mesh_terms: D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009887:Ophthalmoscopy; D012160:Retina / Q000473:pathology; D012164:Retinal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage; D014606:Uveitis, Anterior / Q000175:diagnosis* / Q000473:pathology; D014822:Vitreous Body / Q000473:pathology*; D008061:Whipple Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology
chemical_list: D015662:Trimethoprim, Sulfamethoxazole Drug Combination