Sequence of a cDNA clone encoding the Atlantic salmon alpha 1-microglobulin/bikunin protein.
We report here the nucleotide sequence of a cDNA clone encoding the salmon (Salmo salar) alpha 1-microglobulin/bikunin precursor protein (sAMBP). The encoded precursor shows 36 and 42% amino acid (aa) similarity to the AMBP of pig and human, respectively. Signature aa motifs are conserved. The data infer that the ancestral AMBP gene arose more than 450 million years ago, before the tetrapod-fish divergence.
Hanley
S
S
Department of Microbiology, University College, Galway, Ireland.
Powell
R
R
D000510:Alpha-Globulins / Q000235:genetics*; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary; D006023:Glycoproteins / Q000235:genetics*; D006801:Humans; D008562:Membrane Glycoproteins; D008969:Molecular Sequence Data; D011480:Protease Inhibitors; D012474:Salmon / Q000235:genetics*; D014360:Trypsin Inhibitor, Kunitz Soybean
D000510:Alpha-Globulins; D018076:DNA, Complementary; D006023:Glycoproteins; D008562:Membrane Glycoproteins; D011480:Protease Inhibitors; C109148:SPINT2 protein, human; C016001:alpha-1-microglobulin; D014360:Trypsin Inhibitor, Kunitz Soybean