Dose-response relationships of micronuclei in human lymphocytes induced by fission neutrons and by low LET radiations.
The induction of micronuclei in cytokinesis-blocked human lymphocytes of different donors has been measured after G0 irradiation in vitro with a mixed fission neutron-gamma-ray beam, 220 kV X-rays and 60Co gamma-rays. The dose-response relationships for the micronucleus yields were linear-quadratic for both types of low LET radiations. The linear model applied for neutron-induced micronuclei over the dose range 0-0.66 Gy. At higher doses a saturation effect became apparent. For neutron-induced micronucleus yields a limiting RBE value of 12.2 was derived from the ratio of the alpha coefficients of neutrons and 60Co gamma-rays.
Huber
R
R
Institute of Radiobiology, GSF-Forschungszentrum für Umwelt und Gesundheit, Oberschleissheim, Germany.
Schraube
H
H
Nahrstedt
U
U
Braselmann
H
H
Bauchinger
M
M
D002478:Cells, Cultured; D003037:Cobalt Radioisotopes; D004307:Dose-Response Relationship, Radiation; D004735:Energy Transfer; D005214:Fast Neutrons; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000648:ultrastructure; D048629:Micronuclei, Chromosome-Defective / Q000528:radiation effects*; D011829:Radiation Dosage; D012062:Relative Biological Effectiveness; D014965:X-Rays
D003037:Cobalt Radioisotopes