Colorectal cancer prognosis and expression of exon-v6-containing CD44 proteins.
CD44 variants containing v6 confer metastatic potential to rat carcinoma cell-lines. In man, CD44v6 is increasingly expressed during colorectal tumour progression. In 68 colorectal carcinoma patients, survival analysis showed that CD44v6 expression in the tumours was associated with tumour-related death. In patients who had an apparently radical resection of their primary tumour, CD44v6 expression had prognostic value independent of Dukes' stage. CD44v6 expression may reflect propensity for metastasis after apparently curative surgery, making adjuvant therapy an option in these patients.
Mulder
J W
JW
Department of Pathology, University of Amsterdam, Netherlands.
Kruyt
P M
PM
Sewnath
M
M
Oosting
J
J
Seldenrijk
C A
CA
Weidema
W F
WF
Offerhaus
G J
GJ
Pals
S T
ST
D002352:Carrier Proteins / Q000276:immunology*; D015179:Colorectal Neoplasms / Q000235:genetics / Q000276:immunology* / Q000473:pathology; D005091:Exons; D006801:Humans; D018960:Hyaluronan Receptors; D009367:Neoplasm Staging; D011379:Prognosis; D011956:Receptors, Cell Surface / Q000276:immunology*; D016201:Receptors, Lymphocyte Homing / Q000276:immunology*; D016019:Survival Analysis
D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D011956:Receptors, Cell Surface; D016201:Receptors, Lymphocyte Homing