Dideoxy sequencing and structural analysis of the rat insulin-like growth factor binding protein-1 gene.
Insulin-like growth factor binding protein-1 (IGFBP-1) is an important modulator of IGF bioavailability. To facilitate studies of IGFBP-1 regulation and function in rodent models, we cloned the rat IGFBP-1 gene and analyzed its structure by dideoxy sequencing. The rat IGFBP-1 gene is relatively small (approximately 5 kb) and contains 4 exons and 3 introns, similar to the human IGFBP-1 gene.
Lacson
R
R
Department of Medicine, University of Illinois College of Medicine, Chicago.
Oehler
D
D
Yang
E
E
Goswami
R
R
Unterman
T
T
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D003001:Cloning, Molecular; D018076:DNA, Complementary; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I; D008969:Molecular Sequence Data; D051381:Rats
D002352:Carrier Proteins; D018076:DNA, Complementary; D018970:Insulin-Like Growth Factor Binding Protein 1; D007334:Insulin-Like Growth Factor I