title: 1-Aryl-2-amino/hydrazino-4-phenyl-1,6-dihydro-1,3,5-triazine-6-thione and related thiocarbamides/thiosemicarbazides as antithyroidal agents.
abstract: Different 1-aryl-2-benzylmercapto-4-phenyl-1,6-dihydro-1,3,5-triazine-6- thiones have been synthesized by known methods. These triazines on treatment with ammonia/hydrazine hydrate afforded the corresponding 1-aryl-2-amino/hydrazino-4-phenyl-1,6-dihydro-1,3,5-triazine-6-thiones which on treatment with arylisothiocyanates afforded the related thiocarbamide/thiosemicarbazides. Some of these compounds show appreciable antithyroidal activity.
authors.affiliation: Department of Chemistry, Banaras Hindu University, Varanasi, India.
authors.forename: R
authors.initials: R
authors.lastname: Prasad
authors.forename: P K
authors.initials: PK
authors.lastname: Srivastava
mesh_terms: D000818:Animals; D013956:Antithyroid Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D013889:Thiouracil / Q000494:pharmacology; D014227:Triazines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D013956:Antithyroid Agents; D014227:Triazines; D013889:Thiouracil