title: Substance P containing polymer implants protect against striatal excitotoxicity.
abstract: The present study examined whether substance P (Sub P) could protect against quinolinic acid (QA)-induced lesions of the striatum, as measured by a loss of striatal D1 dopamine receptors. Sub P was extruded into Evac polymer rods for slow release. One 4 mm rod segment was implanted unilaterally into the striatum of each rat. One week later, animals received a striatal injection of QA (50, 75 or 100 nmol/microliters) medial to the implanted rod. Controls received QA alone. Three weeks later, there was a dose-dependent loss of D1 receptors following QA. Sub P rods protected the striatum from QA-induced D1 receptor loss at this time. These results support the neuroprotection role of Sub P on excitotoxicity.
authors.affiliation: Department of Surgery, University of South Florida, College of Medicine, Tampa 33612.
authors.forename: P R
authors.initials: PR
authors.lastname: Sanberg
authors.forename: D F
authors.initials: DF
authors.lastname: Emerich
authors.forename: P
authors.initials: P
authors.lastname: Aebischer
authors.forename: S M
authors.initials: SM
authors.lastname: Amisetti
authors.forename: W
authors.initials: W
authors.lastname: Ouellette
authors.forename: T K
authors.initials: TK
authors.lastname: Koutouzis
authors.forename: D W
authors.initials: DW
authors.lastname: Cahill
authors.forename: A B
authors.initials: AB
authors.lastname: Norman
mesh_terms: D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects*; D008297:Male; D011108:Polymers; D019736:Prostheses and Implants; D017378:Quinolinic Acid / Q000037:antagonists & inhibitors*; D011869:Radioligand Assay; D051381:Rats; D017207:Rats, Sprague-Dawley; D017447:Receptors, Dopamine D1 / Q000187:drug effects; D013373:Substance P / Q000032:analysis / Q000494:pharmacology*
chemical_list: D011108:Polymers; D017447:Receptors, Dopamine D1; D013373:Substance P; D017378:Quinolinic Acid