title: RNA polymerase: structural determinant of the chromatin loop and the chromosome.
abstract: Current models for RNA synthesis involve an RNA polymerase that tracks along a static template. However, research on chromatin loops suggests that the template slides past a stationary polymerase; individual polymerases tie the chromatin fibre into loops and clusters of polymerases determine the basic structure of the interphase and metaphase chromosome. RNA polymerase is then both a player and a manager of the chromosome loop.
authors.affiliation: CRC Nuclear Structure and Function Research Group, Sir William Dunn School of Pathology, University of Oxford, UK.
authors.forename: P R
authors.initials: PR
authors.lastname: Cook
mesh_terms: D016477:Artifacts; D001426:Bacterial Proteins / Q000378:metabolism; D002466:Cell Nucleolus / Q000378:metabolism; D002843:Chromatin / Q000378:metabolism / Q000648:ultrastructure*; D002875:Chromosomes / Q000378:metabolism / Q000648:ultrastructure*; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004261:DNA Replication; D012321:DNA-Directed RNA Polymerases / Q000737:chemistry / Q000378:metabolism*; D004800:Enzymes, Immobilized; D008863:Microspheres; D008957:Models, Genetic; D009068:Movement; D010784:Photomicrography; D011485:Protein Binding; D012313:RNA / Q000096:biosynthesis*; D013048:Specimen Handling; D013698:Templates, Genetic; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D002843:Chromatin; D004800:Enzymes, Immobilized; D012313:RNA; D004247:DNA; D012321:DNA-Directed RNA Polymerases