Angiotensin AT1 receptor blockade by specific antibody prevented two-kidney, one-clip renal hypertension in the rat.
The effect of chronic angiotensin AT1 receptor blockade by a specific antibody on the development of two-kidney, one-clip renal hypertension was studied in Wistar rats. Renal artery constriction resulted in a fast and large increase in blood pressure in comparison with that of control rats. On the other hand, the pre-immunization of rats with a small part of the angiotensin AT1 receptor completely prevented the development of renal hypertension. We conclude that the development of two-kidney, one-clip renal hypertension can be blocked by a specific antibody raised against a part of the angiotensin AT1 receptor.
Zelezná
B
B
Institute of Molecular Genetics, Prague, Czech Republic.
Veselský
L
L
Velek
J
J
Zicha
J
J
Kunes
J
J
D000595:Amino Acid Sequence; D000803:Angiotensin I / Q000378:metabolism*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D001794:Blood Pressure / Q000502:physiology; D006978:Hypertension, Renovascular / Q000503:physiopathology / Q000517:prevention & control*; D008297:Male; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000138:chemical synthesis / Q000276:immunology; D051381:Rats; D017208:Rats, Wistar; D011945:Receptors, Angiotensin / Q000276:immunology; D012077:Renal Artery / Q000502:physiology; D005719:gamma-Globulins / Q000276:immunology
D057911:Angiotensin Receptor Antagonists; D010446:Peptide Fragments; D011945:Receptors, Angiotensin; D005719:gamma-Globulins; D000803:Angiotensin I