Peptidergic nerves in the ureter.
Vasoactive intestinal peptide (VIP) and substance P were demonstrated in the pig ureter by immunohistochemical techniques. Nerves containing these materials were related mainly to the smooth muscle layer in the normal and obstructed ureter. In isolated ureteral segments, VIP caused relaxation at doses exceeding 0.18 micrograms/ml, with no significant difference seen in the effect on normal and obstructed ureter. Vasoactive intestinal polypeptide may play a role in the regulation of ureteral smooth muscle tone.
Godet
A
A
Department of Urology, University of Iowa College of Medicine, Iowa City.
Heidger
P M
PM
Winfield
H N
HN
D000818:Animals; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D008297:Male; D009130:Muscle, Smooth / Q000737:chemistry / Q000294:innervation; D009474:Neurons / Q000737:chemistry* / Q000166:cytology / Q000502:physiology; D013373:Substance P / Q000032:analysis*; D013552:Swine; D014513:Ureter / Q000294:innervation* / Q000502:physiology; D014517:Ureteral Obstruction / Q000473:pathology / Q000503:physiopathology; D014660:Vasoactive Intestinal Peptide / Q000032:analysis*
D013373:Substance P; D014660:Vasoactive Intestinal Peptide