title: Adequate enzymatic substitution in treating exocrine pancreatic insufficiency.
abstract: The chymotrypsin in the stool test was used to monitor adequate enzymatic substitution in treating exocrine pancreatic insufficiency with 18 patients (16 suffering from chronic pancreatitis and 2 having passed duodenopancreatectomy due to pancreatic cancer). This test helps to identify pancreatic insufficiency and can be successfully used in monitoring the adequate amount of pancreatic substitute, which, we have found, differs from patient to patient. The dosage can be higher in cases of chronic pancreatitis than in those required after duodenopancreatectomy.
authors.affiliation: 2nd Medical Clinic, Medical Faculty, Palacký University, Olomouc, Czech Republic.
authors.forename: I
authors.initials: I
authors.lastname: Simek
authors.forename: K
authors.initials: K
authors.lastname: Kubias
authors.forename: M
authors.initials: M
authors.lastname: Duda
mesh_terms: D000681:Amylases / Q000627:therapeutic use*; D002908:Chronic Disease; D002918:Chymotrypsin / Q000032:analysis; D016903:Drug Monitoring; D010450:Endopeptidases / Q000627:therapeutic use*; D005243:Feces; D006801:Humans; D008049:Lipase / Q000627:therapeutic use*; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000601:surgery; D016577:Pancreaticoduodenectomy; D010194:Pancreatin / Q000627:therapeutic use*; D010195:Pancreatitis / Q000188:drug therapy*
chemical_list: D010194:Pancreatin; D008049:Lipase; D000681:Amylases; D010450:Endopeptidases; D002918:Chymotrypsin