Insulin-like growth factors I and II are reduced in plasma from growth retarded children with chronic liver disease.
This study shows that blood from young children (< 3 years) with end stage liver disease, contains less IGF-I, IGF-II and IGFBPs than blood from normally growing children without liver disease, despite the provision of adequate calories. These low levels are likely to contribute to growth failure in children with end stage liver disease.
Quirk
P
P
Children's Nutrition Research Centre, Royal Children's Hospital, Brisbane, Australia.
Owens
P
P
Moyse
K
K
Chin
S
S
Wall
C
C
Ballard
J
J
Shepherd
R
R
D002352:Carrier Proteins / Q000097:blood; D002675:Child, Preschool; D002908:Chronic Disease; D005260:Female; D006130:Growth Disorders / Q000097:blood* / Q000209:etiology; D006801:Humans; D007223:Infant; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007335:Insulin-Like Growth Factor II / Q000378:metabolism*; D008107:Liver Diseases / Q000097:blood* / Q000150:complications; D008297:Male
D002352:Carrier Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II