title: Structural organization of the genes encoding human and murine FK506-binding protein (FKBP) 13 and comparison to FKBP1.
abstract: FK506-binding protein (FKBP)12 and FKBP13 are members of a family of proteins which bind the immunosuppressant drugs, FK506 and rapamycin. FKBP12 and FKBP13 are encoded by distinct genes, designated FKBP1 and FKBP2, respectively. The structure of human FKBP1 was previously characterized. We now report the genomic structure of the human and murine FKBP2 genes. Comparison of FKBP1 and FKBP2 reveals significant homology and correlation of intron positions in the C-terminal region, suggesting that these genes may have evolved from a common ancestral gene.
authors.affiliation: Division of Infectious Diseases, Children's Hospital, Boston, MA 02115.
authors.forename: B A
authors.initials: BA
authors.lastname: Hendrickson
authors.forename: W
authors.initials: W
authors.lastname: Zhang
authors.forename: R J
authors.initials: RJ
authors.lastname: Craig
authors.forename: Y J
authors.initials: YJ
authors.lastname: Jin
authors.forename: B E
authors.initials: BE
authors.lastname: Bierer
authors.forename: S
authors.initials: S
authors.lastname: Burakoff
authors.forename: A G
authors.initials: AG
authors.lastname: DiLella
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015139:Blotting, Southern; D002352:Carrier Proteins / Q000235:genetics*; D003001:Cloning, Molecular; D005091:Exons; D006360:Heat-Shock Proteins / Q000235:genetics*; D006801:Humans; D007438:Introns; D051379:Mice; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D016559:Tacrolimus; D022021:Tacrolimus Binding Proteins
chemical_list: D002352:Carrier Proteins; D006360:Heat-Shock Proteins; C070133:FKBP-13; D022021:Tacrolimus Binding Proteins; D016559:Tacrolimus