Effect of contignasterol on histamine release induced by anti-immunoglobulin E from rat peritoneal mast cells.
In rat peritoneal mass cells induced by anti-immunoglobulin E (anti-IgE), contignasterol (1) inhibited histamine release in a dose-dependent manner. On the other hand, a reduction product of contignasterol (2) did not inhibit histamine release from mast cells induced by anti-IgE.
Takei
M
M
Forschungsinstitut Borstel, Germany.
Burgoyne
D L
DL
Andersen
R J
RJ
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D006636:Histamine Release / Q000187:drug effects*; D007073:Immunoglobulin E / Q000276:immunology*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000276:immunology / Q000378:metabolism*; D010084:Oxidation-Reduction; D010529:Peritoneal Cavity / Q000166:cytology; D011161:Porifera / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D013261:Sterols / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D000888:Antibodies, Anti-Idiotypic; D013261:Sterols; C091550:contignasterol; D007073:Immunoglobulin E