title: [Whipple's disease--a rare cause of secondary amyloidosis].
abstract: Two cases of Whipple's disease with secondary amyloidosis are described. One patient had a nephrotic syndrome, the other malabsorption. The chronic inflammatory stimulus of Whipple's disease is discussed as a trigger for the development of secondary amyloidosis. The clinical symptoms of seronegative arthritis, weight loss, chronic diarrhea, intermittent fever and lymphadenopathy may be the clue to the diagnosis of Whipple's disease. Peroral intestinal biopsy is the diagnostic procedure of choice. Adequate antibiotic treatment with a regimen of penicillin and trimethoprim-sulfamethoxazole is indicated and prevents the development of secondary amyloidosis.
authors.affiliation: Medizinische Klinik I, Kliniken der Stadt Köln, Krankenhaus Merheim.
authors.forename: P
authors.initials: P
authors.lastname: Leidig
authors.forename: M
authors.initials: M
authors.lastname: Stolte
authors.forename: B
authors.initials: B
authors.lastname: Krakamp
authors.forename: S
authors.initials: S
authors.lastname: Störkel
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000686:Amyloidosis / Q000209:etiology* / Q000473:pathology; D001706:Biopsy; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D007678:Kidney Glomerulus / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology / Q000473:pathology; D000685:Serum Amyloid A Protein / Q000032:analysis; D008061:Whipple Disease / Q000150:complications* / Q000473:pathology
chemical_list: D000685:Serum Amyloid A Protein