Cyclic AMP-gated cation channels of olfactory receptor neurons.
Odor-induced electrical activity in vertebrate olfactory receptor neurons is, at least in part, the result of the direct cyclic AMP-dependent activation of a nonselective cation channel. Single-channel recordings from extraciliary regions of isolated salamander olfactory receptor neurons have greatly improved our knowledge about distinctive properties of the cAMP-gated channel such as channel kinetics, modulation through divalent cations, and pharmacology. Because of the central role of these channels in the transduction cascade, these efforts have led to a better understanding of the physiology of olfactory transduction.
Zufall
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Section of Neurobiology, Yale University, School of Medicine, New Haven, Connecticut 06510.
D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D002412:Cations / Q000378:metabolism; D002413:Cations, Divalent / Q000494:pharmacology; D002462:Cell Membrane / Q000187:drug effects / Q000502:physiology; D000242:Cyclic AMP / Q000378:metabolism*; D006152:Cyclic GMP / Q000494:pharmacology; D015640:Ion Channel Gating / Q000502:physiology; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009474:Neurons / Q000502:physiology*; D009812:Odorants; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction; D012903:Smell / Q000502:physiology*; D014562:Caudata
D002412:Cations; D002413:Cations, Divalent; D007473:Ion Channels; D000242:Cyclic AMP; D006152:Cyclic GMP; D015056:1-Methyl-3-isobutylxanthine