Cytotoxic and genetic effects of X-irradiation of human cells in the presence of chlorpromazine.
Human epidermoid carcinoma cells (Hep-2) were X-irradiated in the presence of 5-10 micrograms/ml of chlorpromazine (CPZ). Survival of the cells decreased with increasing CPZ concentration. Lymphocytes from three normal volunteers exposed to X-irradiation in the presence of CPZ showed an increased frequency of dicentric and ring formation.
Karmakar
P
P
Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, India.
Dasgupta
U B
UB
Poddar
R K
RK
D000328:Adult; D002470:Cell Survival / Q000187:drug effects* / Q000528:radiation effects*; D002746:Chlorpromazine / Q000633:toxicity*; D002869:Chromosome Aberrations; D006801:Humans; D007621:Karyotyping; D008214:Lymphocytes / Q000187:drug effects / Q000528:radiation effects; D011836:Radiation Tolerance / Q000187:drug effects*; D014407:Tumor Cells, Cultured; D014965:X-Rays
D002746:Chlorpromazine