[The effects of salvia miltiorrhiza, polysaccharide sulphate, dextran 40 and mannitol on the viscoelasticity properties of red blood cell suspension].
In vitro, the effects of Dextran 40(DX40), mannitol, salvia miltiorrhiza and polysaccharide Sulphate (PSS) on the viscoelasticity properties of red cell suspensions were studied. The results demonstrated that when the concentration of the drugs increased, mannitol increased eta 5 x 96, eta 51 x 2, eta', eta" and G', and DX 40 increased the values of eta' eta" and G', but it had no obvious effect on eta 5 x 96 and eta 51 x 2; salvia miltiorrhiza and PSS had no obvious effect on eta 5 x 96, eta 51 x 2, eta', eta'' and G'. However, the average values of eta', eta'' and G' of Salvia miltiorrhiza and PSS groups were lower than those of DX 40 and Mannitol groups. Clinically, these four drugs in treatment doses might improve viscoelasticity properties of whole blood. For treating the ischemic cerebral vascular diseases and hyperviscosity syndromes, Salvia miltiorrhiza and PSS could be infused faster, but DX40 and mannitol should be infused slowly.
Yang
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Y
Wang
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L
Li
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L
Chen
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H
D001809:Blood Viscosity / Q000187:drug effects*; D003911:Dextrans / Q000494:pharmacology; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D004548:Elasticity; D004912:Erythrocytes / Q000187:drug effects*; D006801:Humans; D008353:Mannitol / Q000494:pharmacology; D010936:Plant Extracts; D011134:Polysaccharides / Q000494:pharmacology*; D027561:Salvia miltiorrhiza
D003911:Dextrans; D004365:Drugs, Chinese Herbal; D010936:Plant Extracts; D011134:Polysaccharides; D008353:Mannitol