Evaluation of Caralluma tuberculata pretreatment for the protection of rat gastric mucosa against toxic damage.
The ethanolic extract of Caralluma tuberculata N. E. Brown has been screened for its potential to protect gastric mucosa against the injuries caused by 80% ethanol, 0.2 M NaOH, hypertonic saline, and indomethacin. C. tuberculata at doses of 250, 500, and 1000 mg/kg body wt given 30 min before the necrotizing agents provided dose-dependent protection against the damage caused by all tested agents. The effects caused by ethanol were further investigated. Treatment of rats with 1 ml of 80% ethanol (gavage) was found to cause depletion of stomach-wall mucus, to lower the concentrations of proteins, nucleic acids, and nonprotein sulfhydryl groups in the stomach wall, and to cause histopathological lesions, including necrosis, erosions, congestion, and hemorrhage, of the stomach wall. C. tuberculata treatment caused a dose-dependent protection against all these effects. In the same manner it affected malondialdehyde concentrations altered by ethanol treatment. C. tuberculata also offered protection against mucosal damage caused by indomethacin. The protective effects of C. tuberculata in addition to its effects on mucus production and nonprotein sulfhydryl concentration may be mediated through its free radical scavenging and prostaglandin inducing properties.
al-Harbi
M M
MM
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Qureshi
S
S
Raza
M
M
Ahmed
M M
MM
Afzal
M
M
Shah
A H
AH
D000284:Administration, Oral; D000818:Animals; D004247:DNA / Q000032:analysis; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000633:toxicity*; D005753:Gastric Mucosa / Q000187:drug effects*; D007213:Indomethacin / Q000037:antagonists & inhibitors / Q000633:toxicity; D008297:Male; D008315:Malondialdehyde / Q000032:analysis; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D011506:Proteins / Q000032:analysis; D012313:RNA / Q000032:analysis; D051381:Rats; D017208:Rats, Wistar; D012965:Sodium Chloride / Q000633:toxicity; D012972:Sodium Hydroxide / Q000633:toxicity; D013270:Stomach / Q000737:chemistry* / Q000473:pathology; D013438:Sulfhydryl Compounds / Q000032:analysis
D010936:Plant Extracts; D011506:Proteins; D013438:Sulfhydryl Compounds; D000431:Ethanol; D012965:Sodium Chloride; D008315:Malondialdehyde; D012972:Sodium Hydroxide; D012313:RNA; D004247:DNA; D007213:Indomethacin