title: RNA expression of complement regulatory proteins in human brain tumors.
abstract: The expression of complement regulatory proteins (CRP) on the surface of neoplastic cells has been proposed as a mechanism by which these cells evade immune surveillance. We have examined the RNA expression of the genes that encode 5 kinds of CRP in various human brain tumors to determine whether CRP expression might play a role in the malignant progression of these tumors. The benign and atypical meningiomas, and the astrocytomas showed high expression of SP-40,40, low expression of CD59, and barely detectable expression of CD46, CD55 and S-protein. The benign and atypical menigiomas showed significantly greater expression of SP-40,40 at the RNA level when compared to malignant meningiomas. This study describes the mRNA expression of meningiomas, astrocytomas, tumor cell lines and normal human tissues.
authors.affiliation: Department of Molecular Genetics, Biochemistry and Microbiology, University of Cincinnati College of Medicine, OH 45267-0524.
authors.forename: N
authors.initials: N
authors.lastname: Shinoura
authors.forename: S C
authors.initials: SC
authors.lastname: Heffelfinger
authors.forename: M
authors.initials: M
authors.lastname: Miller
authors.forename: O I
authors.initials: OI
authors.lastname: Shamraj
authors.forename: N H
authors.initials: NH
authors.lastname: Miura
authors.forename: J J
authors.initials: JJ
authors.lastname: Larson
authors.forename: N
authors.initials: N
authors.lastname: DeTribolet
authors.forename: R E
authors.initials: RE
authors.lastname: Warnick
authors.forename: J J
authors.initials: JJ
authors.lastname: Tew
authors.forename: A G
authors.initials: AG
authors.lastname: Menon
mesh_terms: D015703:Antigens, CD / Q000235:genetics; D001254:Astrocytoma / Q000235:genetics; D001483:Base Sequence; D001932:Brain Neoplasms / Q000235:genetics*; D018958:CD55 Antigens; D018957:CD59 Antigens; D051152:Clusterin; D003169:Complement Inactivator Proteins / Q000235:genetics*; D006023:Glycoproteins; D006801:Humans; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins / Q000235:genetics; D008579:Meningioma / Q000235:genetics; D018832:Molecular Chaperones; D008969:Molecular Sequence Data; D012313:RNA / Q000032:analysis*; D014407:Tumor Cells, Cultured; D019096:Vitronectin
chemical_list: D015703:Antigens, CD; D018958:CD55 Antigens; D018957:CD59 Antigens; D051152:Clusterin; D003169:Complement Inactivator Proteins; D006023:Glycoproteins; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins; D018832:Molecular Chaperones; D012313:RNA; D019096:Vitronectin; C497857:CD46 protein, human; C495242:CLU protein, human