Econazole, a blocker of Ca2+ influx, selectively suppresses LTP of EPSPs in hippocampal slices.
Econazole--an agent that suppresses Ca2+ influx triggered by depletion of internal Ca-stores in non-excitable cells--was bath-applied to submerged slices from Sprague-Dawley rats. Econazole (15-20 microM) had no consistent effect on afferent volleys, EPSPs or population spikes; but in seven out of nine slices, it prevented the induction of tetanic long-term potentiation (LTP) of field EPSPS. By contrast, all slices showed a marked LTP of population spikes. Ca2+ influx induced by tetanic depletion of Ca2+ stores may be essential for LTP of excitatory synaptic transmission.
Forghani
R
R
Anaesthesia Research Department, McGill University, McIntyre Centre, Montréal, PQ, Canada.
Krnjević
K
K
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004464:Econazole / Q000494:pharmacology*; D006624:Hippocampus / Q000187:drug effects*; D017774:Long-Term Potentiation / Q000187:drug effects*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D002121:Calcium Channel Blockers; D004464:Econazole