title: Co-expression of endothelial cell and macrophage antigens in Kaposi's sarcoma cells.
abstract: The histopathogenesis of Kaposi's sarcoma (KS) was investigated using immunocytochemistry in 12 skin biopsies obtained from two AIDS patients, nine patients with the classic form, and one organ-transplant patient. KS cells revealed a peculiar antigenic profile, being characterized by co-expression of endothelial and macrophage markers. KS cells were stained for von Willebrand factor (vWF); for vascular endothelial (VE) cadherin, an endothelial specific adhesion molecule; and for PECAM/CD31. In addition, they expressed the macrophage antigens PAM-1, CD68, and CD14, and were positive for vitronectin receptor and alpha-1,5,6/beta-1 integrins. KS cells were weakly stained for ICAM-1 in 6 of 12 cases and were negative for VCAM-1 and E-selectin.
authors.affiliation: II Pathological Anatomy, University La Sapienza, Roma, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Uccini
authors.forename: L P
authors.initials: LP
authors.lastname: Ruco
authors.forename: F
authors.initials: F
authors.lastname: Monardo
authors.forename: A
authors.initials: A
authors.lastname: Stoppacciaro
authors.forename: E
authors.initials: E
authors.lastname: Dejana
authors.forename: I L
authors.initials: IL
authors.lastname: La Parola
authors.forename: D
authors.initials: D
authors.lastname: Cerimele
authors.forename: C D
authors.initials: CD
authors.lastname: Baroni
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology / Q000473:pathology*; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D002196:Capillaries; D015815:Cell Adhesion Molecules / Q000032:analysis; D004729:Endothelium, Lymphatic / Q000473:pathology*; D004730:Endothelium, Vascular / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D016023:Integrins / Q000032:analysis; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D018950:Lipopolysaccharide Receptors; D008264:Macrophages / Q000276:immunology / Q000473:pathology*; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D016024:Receptors, Cytoadhesin / Q000032:analysis; D019030:Receptors, Vitronectin; D012514:Sarcoma, Kaposi / Q000276:immunology / Q000473:pathology*; D012867:Skin / Q000473:pathology*; D019010:Vascular Cell Adhesion Molecule-1; D014841:von Willebrand Factor / Q000032:analysis; D000097382:CD68 Molecule
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D000951:Antigens, Neoplasm; D015815:Cell Adhesion Molecules; D016023:Integrins; D018799:Intercellular Adhesion Molecule-1; D018950:Lipopolysaccharide Receptors; D019408:Platelet Endothelial Cell Adhesion Molecule-1; D016024:Receptors, Cytoadhesin; D019030:Receptors, Vitronectin; D019010:Vascular Cell Adhesion Molecule-1; D014841:von Willebrand Factor; C067980:CD68 antigen, human; D000097382:CD68 Molecule