CSF 5-HIAA predicts suicide risk after attempted suicide.
Suicide risk after attempted suicide, as predicted by cerebrospinal fluid (CSF) monoamine metabolite concentrations, was studied in a sample of 92 psychiatric mood disorder inpatients admitted shortly after attempting suicide. The potential of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) in the CSF to predict suicide risk within the first year after attempted suicide was studied by means of survival analysis after after median split subgrouping. Eleven patients (12%) committed suicide within 1 year after attempted suicide. Eight of these belonged to the below-the-median (< 87 nM) CSF 5-HIAA subgroup, that is, the suicide risk was 17% as compared with 7% among those with above-the-median CSF 5-HIAA. The cumulative number of survived patient-months during the first year after attempted suicide was significantly lower in the low CSF 5-HIAA subgroup. It was concluded that low CSF 5-HIAA predicts short-range suicide risk after attempted suicide in mood disorder psychiatric inpatients. These findings lend further support to the serotonin hypothesis of suicide risk.
Nordström
P
P
Department of Clinical Neuroscience, Karolinska Institute, Stockholm.
Samuelsson
M
M
Asberg
M
M
Träskman-Bendz
L
L
Aberg-Wistedt
A
A
Nordin
C
C
Bertilsson
L
L
D000328:Adult; D000368:Aged; D001008:Anxiety Disorders / Q000134:cerebrospinal fluid / Q000401:mortality / Q000523:psychology; D001714:Bipolar Disorder / Q000134:cerebrospinal fluid* / Q000401:mortality / Q000523:psychology; D002423:Cause of Death; D003866:Depressive Disorder / Q000134:cerebrospinal fluid* / Q000401:mortality / Q000523:psychology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000134:cerebrospinal fluid*; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D011618:Psychotic Disorders / Q000134:cerebrospinal fluid / Q000401:mortality / Q000523:psychology; D012307:Risk Factors; D012701:Serotonin / Q000502:physiology; D013405:Suicide / Q000523:psychology / Q000706:statistics & numerical data; D013406:Suicide, Attempted / Q000523:psychology* / Q000706:statistics & numerical data; D000092864:Suicide Prevention
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid