Assignment of the human gene for the water channel of renal collecting duct Aquaporin 2 (AQP2) to chromosome 12 region q12-->q13.
The chromosomal localization of the gene encoding Aquaporin 2 (previously called WCH-CD), which acts as a water channel in the collecting tubules of the kidney, was determined. Southern blot hybridizations of chromosomal DNA from a panel of 25 different human-rodent hybrid cell lines assigned AQP2 to the q-arm of human chromosome 12. Additionally, in situ hybridization on R-banded metaphase chromosomes localized AQP2 to the q12-->q13 region of this chromosome.
Deen
P M
PM
Department of Physiology, University of Nijmegen, The Netherlands.
Weghuis
D O
DO
Sinke
R J
RJ
Geurts van Kessel
A
A
Wieringa
B
B
van Os
C H
CH
D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D017931:DNA Primers; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping
C496023:AQP2 protein, human; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D017931:DNA Primers; D007473:Ion Channels; D008565:Membrane Proteins