Increase in the concentrations of brain serotonin and 5-hydroxyindoleacetic acid during growth of a transplanted murine lymphoma.
The concentrations of serotonin (5-HT) and its metabolite, 5-hydroxyindoleacetic acid (5-HIAA) were studied in discrete brain areas of mice bearing transplantable Dalton's lymphoma (DL). Marked rise in 5-HT level (p < 0.05) was observed in serotonin secreting cell rich area--raphe region--as well as in hypothalamus and caudate putamen. High 5-HT level in these discrete areas was maintained throughout the period of tumor growth. Appreciable increase in 5-HT concentration was also observed in midbrain at the late stage (day 15 post-transplantation) of tumor growth. Unlike 5-HT, there was little change in 5-HIAA levels at the early stage (day 7) of tumor growth, and this was followed by a fall in 5-HIAA level around day 10 post-transplantation. However, the concentration of this 5-HT metabolite increased considerably at the late phase of tumor proliferation. The results suggest a close relationship between serotonin level in discrete brain regions and growth of an experimental tumor in mice.
Banik
S
S
Department of Endocrinology, Chittaranjan National Cancer Institute (Research Center), Calcutta, India.
Ray
M R
MR
Choudhury
S
S
Lahiri
T
T
D000818:Animals; D001923:Brain Chemistry; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism*; D008223:Lymphoma / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D012701:Serotonin / Q000378:metabolism*; D013997:Time Factors
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid