Circulating autoantibody to mature neurons and astrocytes of humans and some mammals present in a demented patient with autoimmune disorder.
Circulating autoantibody to a 48-kD nuclear protein in neurons and astrocytes of the human and bovine cerebrum were present in the serum of a demented patient with an autoimmune disorder. Other human visceral organs, dorsal root ganglion cells, neuroblastoma and glioblastoma cell lines, and rat cerebrum did not react with the patient's serum. No sera from age-matched controls, including those with Alzheimer's disease, reacted with the 48-kD protein. Only the mature neurons and astrocytes of humans and some mammals express the 48-kD protein. This antibody may be responsible for the patient's demented condition.
Kaneko
K
K
Department of Neurology, Tokyo Medical and Dental University, Japan.
Seki
K
K
Ishida
K
K
Uchihara
T
T
Kanda
T
T
Inuzuka
T
T
Miyatake
T
T
D000368:Aged; D000544:Alzheimer Disease / Q000276:immunology / Q000473:pathology; D000818:Animals; D001253:Astrocytes / Q000276:immunology*; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000276:immunology*; D001921:Brain / Q000276:immunology* / Q000473:pathology; D002417:Cattle; D003704:Dementia / Q000175:diagnosis / Q000276:immunology*; D003937:Diagnosis, Differential; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000276:immunology*; D009687:Nuclear Proteins / Q000276:immunology
D001323:Autoantibodies; D000939:Epitopes; D009687:Nuclear Proteins