Antimutagenicity of three isomers of aminobenzoic acid in Salmonella typhimurium.
The m-, o- and p-isomers of aminobenzoic acid (ABA) repressed the mutagenicity of N-methyl-N'-nitro-N-nitrosoguanidine (MNNG) in Salmonella typhimurium TA100. Their antimutagenic potency was in the order of o-ABA > m-ABA > p-ABA. The mechanism of this antimutagenicity is ascribed mainly to the decomposition of MNNG induced by the aminobenzoic acid isomers outside or within the bacterial cells. The inhibition of plant cell peroxidases and bacterial acetyltransferases that are required for the plant activation of 2-aminofluorene (2-AF) to mutagenic product(s) may participate in the repression of 2-AF mutagenesis by the aminobenzoic acids in S. typhimurium strain YG1024. The aminobenzoic acid isomers exhibited no inhibitory effects towards the direct-acting agent 2-acetoxy-2-acetylaminofluorene, the stable diacetylated metabolic product of 2-AF.
Gichner
T
T
Institute of Experimental Botany, Prague, Czech Republic.
Voutsinas
G
G
Patrineli
A
A
Kappas
A
A
Plewa
M J
MJ
D000099:Acetoxyacetylaminofluorene / Q000633:toxicity*; D000123:Acetyltransferases / Q000037:antagonists & inhibitors; D062365:Aminobenzoates / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000494:pharmacology*; D002460:Cell Line; D005449:Fluorenes / Q000633:toxicity*; D007536:Isomerism; D007700:Kinetics; D009152:Mutagenicity Tests; D010544:Peroxidases / Q000037:antagonists & inhibitors; D010947:Plants, Toxic; D012486:Salmonella typhimurium / Q000187:drug effects*; D013329:Structure-Activity Relationship; D014026:Nicotiana / Q000187:drug effects / Q000201:enzymology
D062365:Aminobenzoates; D016587:Antimutagenic Agents; D005449:Fluorenes; C012177:2-aminofluorene; D000099:Acetoxyacetylaminofluorene; D010544:Peroxidases; D000123:Acetyltransferases