title: Towards engineering pathways for the synthesis of analgesics and antitussives.
authors.affiliation: Institute of Biotechnology, University of Cambridge, United Kingdom.
authors.forename: N C
authors.initials: NC
authors.lastname: Bruce
authors.forename: D A
authors.initials: DA
authors.lastname: Caswell
authors.forename: C E
authors.initials: CE
authors.lastname: French
authors.forename: A M
authors.initials: AM
authors.lastname: Hailes
authors.forename: M T
authors.initials: MT
authors.lastname: Long
authors.forename: D L
authors.initials: DL
authors.lastname: Willey
mesh_terms: D000429:Alcohol Oxidoreductases / Q000235:genetics / Q000378:metabolism; D000449:Aldehyde Reductase / Q000235:genetics; D000595:Amino Acid Sequence; D000700:Analgesics / Q000378:metabolism*; D000996:Antitussive Agents / Q000378:metabolism*; D001426:Bacterial Proteins; D001483:Base Sequence; D001711:Biotransformation; D003001:Cloning, Molecular; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D005798:Genes, Bacterial; D005818:Genetic Engineering; D006853:Hydrocodone / Q000378:metabolism; D004091:Hydromorphone / Q000378:metabolism; D008969:Molecular Sequence Data; D009020:Morphine / Q000737:chemistry / Q000493:pharmacokinetics; D010088:Oxidoreductases / Q000378:metabolism; D016958:Pseudomonas putida / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
chemical_list: D000700:Analgesics; D000996:Antitussive Agents; D001426:Bacterial Proteins; D004269:DNA, Bacterial; D006853:Hydrocodone; D009020:Morphine; D010088:Oxidoreductases; D000429:Alcohol Oxidoreductases; D000449:Aldehyde Reductase; C045221:morphine 6-dehydrogenase; C087820:morphinone reductase; D004091:Hydromorphone