Comparison of amlodipine and captopril in hypertension based on 24-hour ambulatory monitoring.
The efficacy and toleration of once-daily amlodipine (5-10 mg o.d.) and captopril (25-50 mg b.i.d.) were compared in 45 patients with mild-to-moderate essential hypertension. Twenty-four-hour ambulatory blood pressure monitoring was performed at baseline and at the end of the 8-week study period. Clinic blood pressure, heart rate, and adverse events were assessed during a placebo run-in and after 2, 4, and 8 weeks of treatment. Both amlodipine and captopril significantly reduced clinic blood pressure without affecting heart rate. Between-treatment comparisons showed that amlodipine produced a significantly greater reduction in sitting diastolic blood pressure than captopril. Ambulatory blood pressure monitoring revealed a sustained reduction in both systolic and diastolic blood pressure throughout a full 24-h period in patients taking amlodipine. In contrast, however, the effects of captopril were no longer evident during the final 3 h of the dosing interval. Both drugs were generally well tolerated, and the incidence of adverse events was similar in each group. This study demonstrates that amlodipine is more effective as a once-daily antihypertensive agent than captopril administered twice daily.
Lacourcière
Y
Y
Hypertension Research Unit, Le Centre Hospitalier de l'Université Laval, Ste-Foy, Québec, Canada.
Poirier
L
L
Provencher
P
P
D000328:Adult; D000368:Aged; D000553:Ambulatory Care; D017311:Amlodipine / Q000009:adverse effects / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D001795:Blood Pressure Determination / Q000379:methods; D002216:Captopril / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic
D017311:Amlodipine; D002216:Captopril