Value of preoperative PSA in predicting pathologic stage of patients undergoing salvage prostatectomy.
OBJECTIVE
To evaluate the relationship of prostate-specific antigen (PSA) levels and pathologic stage in patients with prostate cancer treated with radiation therapy and undergoing salvage radical prostatectomy.


METHODS
Retrospective analysis of preoperative PSA levels and final pathology in 24 men undergoing salvage prostatectomy following prior radiation therapy.


RESULTS
Although preoperative PSA values were significantly higher in patients with positive surgical margins, preoperative PSA levels failed to predict the presence of absence of extracapsular extension, seminal vesicle involvement, or lymph node metastasis.


CONCLUSIONS
Our results suggest that PSA is not a reliable method of accurately predicting the pathologic stage of patients who are candidates for salvage radical prostatectomy.
Younes
E
E
Department of Urology, Harper Hospital, Detroit, Michigan.
Haas
G P
GP
Montie
J E
JE
Smith
J B
JB
Powell
I J
IJ
Pontes
J E
JE
D000368:Aged; D003131:Combined Modality Therapy; D006801:Humans; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011300:Preoperative Care; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood* / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D012189:Retrospective Studies
D017430:Prostate-Specific Antigen