title: Carbamate analogues of tocainide.
abstract: A series of the new aminoalkyl esters of chlor-, methyl- and alkoxy carbanilates was synthesized. All the compounds prepared were found to exhibit antiarrhythmic activities comparable with those of mexiletine.
authors.affiliation: Department of Medicinal Chemistry, Faculty of Pharmacy, Comenius University, Bratislava, Slovak Republic.
authors.forename: L
authors.initials: L
authors.lastname: Cernusková
authors.forename: L
authors.initials: L
authors.lastname: Benes
authors.forename: J
authors.initials: J
authors.lastname: Csöllei
authors.forename: I
authors.initials: I
authors.lastname: Tumová
authors.forename: P
authors.initials: P
authors.lastname: Svec
mesh_terms: D000157:Aconitine; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000517:prevention & control; D001281:Atrial Fibrillation / Q000139:chemically induced / Q000517:prevention & control; D002219:Carbamates / Q000138:chemical synthesis / Q000494:pharmacology*; D005117:Cardiac Complexes, Premature / Q000139:chemically induced / Q000517:prevention & control; D004837:Epinephrine; D006168:Guinea Pigs; D008801:Mexiletine / Q000494:pharmacology; D010042:Ouabain; D051381:Rats; D016677:Tocainide / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000494:pharmacology*
chemical_list: D000889:Anti-Arrhythmia Agents; D002219:Carbamates; D008801:Mexiletine; D016677:Tocainide; D010042:Ouabain; D000157:Aconitine; D004837:Epinephrine