[EEG and autonomic effects of centrally administered galanin in the rabbit].
The effects of centrally administered galanin (10 and 20 mcg) on the EEG, somatic behaviour and some autonomic parameters have been studied in unanesthetized rabbits. In this species the peptide induced a dose related increase in electrocortical power spectrum density and behavioural sedation. Autonomic changes, consisting in moderate hyperthermia and bradypnea, were seen only after the highest dose of the peptide. These data support a central action of the peptide and suggest a role for galanin as sedative neuropeptide.
Maurelli
M
M
Istituto Neurologico C. Mondino, Università di Pavia.
Marchioni
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Tartara
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D000818:Animals; D001341:Autonomic Nervous System / Q000187:drug effects*; D001522:Behavior, Animal / Q000187:drug effects; D001831:Body Temperature / Q000187:drug effects; D004562:Electrocardiography / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects*; D019004:Galanin; D006993:Hypnotics and Sedatives / Q000494:pharmacology*; D007276:Injections, Intraventricular; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D012119:Respiration / Q000187:drug effects
D006993:Hypnotics and Sedatives; D010455:Peptides; D019004:Galanin