title: Effectiveness of concomitant setiptiline maleate (Tecipul) on negative symptoms of schizophrenia.
abstract: 1. Setiptiline maleate was administered to schizophrenic patients with the object of improving their negative symptoms. 2. Moderate improvements were observed in 58% of the treated patients, thus usefulness of this drug was demonstrated. 3. There was no aggravation of symptoms, and side effects were minor. 4. Measurements of plasma monoamine metabolites showed a tendency of MHPG to decrease and a significant decrease in 5-HIAA, but no change in the level of HVA was observed, suggesting a relationship between the negative symptoms and noradrenaline and/or serotonin systems.
authors.affiliation: Chikusuikai Hospital, Chikusuikai Institute for Neuroinformation, Yame-city, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kuniyoshi
authors.forename: J
authors.initials: J
authors.lastname: Nakamura
authors.forename: C
authors.initials: C
authors.lastname: Miura
authors.forename: K
authors.initials: K
authors.lastname: Inanaga
mesh_terms: D000328:Adult; D015306:Biogenic Monoamines / Q000097:blood; D002908:Chronic Disease; D005260:Female; D006719:Homovanillic Acid / Q000097:blood; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D008297:Male; D008734:Methoxyhydroxyphenylglycol / Q000097:blood; D008803:Mianserin / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood / Q000188:drug therapy*; D012565:Schizophrenic Psychology; D012702:Serotonin Antagonists / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D015306:Biogenic Monoamines; D012702:Serotonin Antagonists; D008803:Mianserin; D008734:Methoxyhydroxyphenylglycol; D006897:Hydroxyindoleacetic Acid; C050605:setiptiline; D006719:Homovanillic Acid