Pharmacological characteristics of potassium-induced, glycogenolysis in astrocytes.
Elevated extracellular concentrations of the potassium ion ([K+]o) stimulate glycogenolysis in primary cultures of mouse astrocytes that have been grown in the presence of dibutyryl cyclic AMP but not in corresponding cultures which have not been treated in this manner. The response is potently inhibited by nifedipine, suggesting that it is evoked by entry of calcium ions through voltage dependent L-channels. The benzodiazepine midazolam, which is known to enhance calcium entry at concentrations of [K+]o causing submaximum calcium entry, increases the glycogenolytic effect by such levels of [K+]o.
Subbarao
K V
KV
Department of Pharmacology, University of Saskatchewan, Saskatoon, Canada.
Stolzenburg
J U
JU
Hertz
L
L
D000818:Animals; D001253:Astrocytes / Q000187:drug effects*; D002478:Cells, Cultured / Q000187:drug effects; D000242:Cyclic AMP / Q000494:pharmacology; D006003:Glycogen / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D008874:Midazolam / Q000494:pharmacology; D009543:Nifedipine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology*; D013997:Time Factors
D006003:Glycogen; D000242:Cyclic AMP; D009543:Nifedipine; D008874:Midazolam; D011188:Potassium