[Immunologic tolerance after experimental liver transplantation].
Allografts in the rat liver are rejected less vigorously than other primarily vascularized allografts; they show a better survival rate and induce donor-specific unresponsiveness or tolerance in some donor-recipient combinations. This overview focuses on the immunologic mechanisms of this privileged status of liver allografts. A variety of possible mechanisms, such as generation of suppressor T-cells, humoral factors and microchimerism, has been related to the observed hyporeactivity. A further analysis of these phenomena may enhance the development of clinical organ transplantation protocols that allow for establishment of donor-specific unresponsiveness without the need for life-long immunosuppression.
Knoop
M
M
Klinik für Allgemein-, Viszeral- und Transplantationschirurgie, Virchow Klinikum, Humboldt Universität zu Berlin.
Neumann
U
U
Neuhaus
P
P
D000818:Animals; D006084:Graft Rejection / Q000276:immunology; D007108:Immune Tolerance / Q000276:immunology; D016031:Liver Transplantation / Q000276:immunology*; D051381:Rats; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014181:Transplantation Immunology / Q000276:immunology; D014184:Transplantation, Homologous