Solubilization of keratin debris in conservative treatment of middle ear cholesteatoma: an in vitro study.
A variety of solutions were tested in vitro to find a suitable solvent which could be used in clinical practice for cholesteatoma debris. Though a little weak as a solvent, a liquid soap composed mainly of plant oil did not cause irritation of the middle ear mucosa, and was thought to be a promising solvent with which to rinse away tenacious debris, especially when used in combination with hydrogen peroxide.
Gyo
K
K
Department of Otolaryngology, Ehime University School of Medicine, Japan.
Sasaki
Y
Y
D002781:Cholesteatoma / Q000628:therapy*; D004427:Ear Diseases / Q000628:therapy; D004432:Ear, Middle; D006801:Humans; D006861:Hydrogen Peroxide / Q000494:pharmacology; D007633:Keratins / Q000187:drug effects*; D012915:Soaps / Q000494:pharmacology; D012995:Solubility; D012997:Solvents / Q000494:pharmacology*; D007507:Therapeutic Irrigation / Q000379:methods
D012915:Soaps; D012997:Solvents; D007633:Keratins; D006861:Hydrogen Peroxide