title: [Poisonous chemicals and urolithiasis].
abstract: For the last 30 years urolithiasis incidence in Kirghizia has been growing. Its prevalence is the highest in Chu and Osh rural areas (89%) where farmers widely use toxic insecticides. Urban population develop the disease more often (63%), especially employees (57.7%) versus workers (27.7%). Urolithiasis occurs in workers 8 times more frequently than in farmers. Food products contain insecticides in quantities much higher than MAC. The contamination concerns fruit and vegetables in a lesser and meat, milk products in greater degrees. In renal tissue, blood, urine of urolithiasis patients concentrations of the chemicals were increased 4 times against the control samples. In renal tissue and fat of urolithiasis animals nephrotoxic insecticides levels surpassed those in the controls 2-3 times. Uroliths contain chemicals in great concentrations also. Basing on the conformity of geography of insecticides us a ge with urolithiasis epidemiological data, high concentrations of the chemicals in food and biological objects, frequent occurrence of recurrent urolithiasis in patients known to acquire high chemicals levels in renal tissue and urine, it is inferred that toxic chemicals are involved in nephrolithiasis genesis by tubular impairment.
authors.forename: M T
authors.initials: MT
authors.lastname: Tynaliev
mesh_terms: D016573:Agrochemicals / Q000009:adverse effects* / Q000032:analysis; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced / Q000378:metabolism; D003634:DDT / Q000009:adverse effects / Q000032:analysis; D005506:Food Contamination / Q000706:statistics & numerical data; D001556:Hexachlorocyclohexane / Q000009:adverse effects / Q000032:analysis; D006801:Humans; D015994:Incidence; D007668:Kidney / Q000737:chemistry; D007707:Kyrgyzstan / Q000453:epidemiology; D010573:Pesticide Residues / Q000009:adverse effects / Q000032:analysis; D015995:Prevalence; D012424:Rural Population / Q000706:statistics & numerical data; D014505:Urban Population / Q000706:statistics & numerical data; D014545:Urinary Calculi / Q000139:chemically induced* / Q000453:epidemiology / Q000378:metabolism / Q000662:veterinary
chemical_list: D016573:Agrochemicals; D010573:Pesticide Residues; D001556:Hexachlorocyclohexane; D003634:DDT