[Experimental choroidal neovascularization in the rat].
We successfully produced, highly (78%) reproducible experimental choroidal neovascularization (ChNV) in the subretinal space of pigmented rats with intense diode laser photocoagulation. ChNV in the pigmented rat was characterized by rapid development of neovascular membrane and proliferation of retinal pigment epithelium in the subretinal space. This procedure may be useful as an experimental model for ChNV.
Tobe
T
T
Department of Ophthalmology, Kansai Medical University, Osaka, Japan.
Takahashi
K
K
Ohkuma
H
H
Uyama
M
M
D000818:Animals; D002829:Choroid / Q000098:blood supply*; D004195:Disease Models, Animal; D017075:Laser Coagulation; D008297:Male; D008854:Microscopy, Electron; D008855:Microscopy, Electron, Scanning; D009389:Neovascularization, Pathologic / Q000473:pathology*; D010857:Pigment Epithelium of Eye / Q000473:pathology / Q000648:ultrastructure; D051381:Rats; D011914:Rats, Inbred BN