Increased platelet activating factor synthesis in experimental colitis after diclofenac and 5-amino-salicylic acid.
We examined the role of platelet activating factor in dextran induced colitis in mice. The release of pro-inflammatory platelet activating factor by colonic mucosa after the application of prednisolone was markedly decreased, unaffected after treatment with the platelet activating factor receptor antagonist BN52021 and significantly increased after treatment with 5-amino-salicylic acid and diclofenac. This increase of platelet activating factor could be responsible for the harmful effects often seen after treatment with specific cyclooxygenase inhibitors during inflammation.
Zijlstra
F J
FJ
Department of Pharmacology, Erasmus University Rotterdam, Netherlands.
Van Dijk
J P
JP
Wilson
J H
JH
D010131:Aminosalicylic Acid / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003092:Colitis / Q000139:chemically induced / Q000378:metabolism*; D003911:Dextrans; D004008:Diclofenac / Q000008:administration & dosage / Q000494:pharmacology*; D004224:Diterpenes; D005260:Female; D046934:Ginkgolides; D007783:Lactones / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D011239:Prednisolone / Q000494:pharmacology
D003911:Dextrans; D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; D004008:Diclofenac; D010131:Aminosalicylic Acid; D011239:Prednisolone; C045856:ginkgolide B