[Inclusion of labeled precursors of macromolecular compounds in the mycobacterial cells in the presence of DP-2 preparation].
The changes in the inclusion of 3H-phenylalanine, methyl-3H-thymidine, [2-14C]-thymidine and [5-3H]-uridine in the cells of pathogenic M. bovis-8, opportunistic M. fortuitum and saprophitic M. phlei, M. B-5 were comparatively investigated in introduction of 0.01 and 0.10% concentrations of the drug DP-2. It is shown that 0.10% DP-2 completely stops the radionuclides supply to the cells. It is suggested that the target of the drug may exist in the sphere of amino acid biosynthesis. The presence of DP-2 is capable of disturbing transport of substances to the cells.
Dermicheva
S G
SG
Dosanov
K Sh
KSh
Koronelli
T V
TV
D000596:Amino Acids / Q000378:metabolism*; D001431:Bacteriological Techniques; D003470:Culture Media; D004269:DNA, Bacterial / Q000096:biosynthesis; D004202:Disinfectants / Q000494:pharmacology*; D007553:Isotope Labeling; D046911:Macromolecular Substances; D009161:Mycobacterium / Q000187:drug effects* / Q000378:metabolism; D009163:Mycobacterium bovis / Q000187:drug effects / Q000378:metabolism; D009168:Mycobacterium phlei / Q000187:drug effects / Q000378:metabolism; D009170:Nontuberculous Mycobacteria / Q000187:drug effects / Q000378:metabolism; D010649:Phenylalanine / Q000378:metabolism; D012329:RNA, Bacterial / Q000096:biosynthesis; D013936:Thymidine / Q000378:metabolism; D014529:Uridine / Q000378:metabolism
D000596:Amino Acids; D003470:Culture Media; D004269:DNA, Bacterial; D004202:Disinfectants; D046911:Macromolecular Substances; D012329:RNA, Bacterial; D010649:Phenylalanine; D013936:Thymidine; D014529:Uridine