Mechanism-based approaches to inhibition of the synthesis and degradation of folate and antifolate polyglutamates.
Kalman
T I
TI
Department of Medicinal Chemistry, State University of New York, Buffalo 14260.
D001692:Biological Transport / Q000187:drug effects; D015195:Drug Design; D005493:Folic Acid Antagonists / Q000378:metabolism* / Q000494:pharmacology*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000378:metabolism; D008727:Methotrexate / Q000031:analogs & derivatives* / Q000378:metabolism; D015394:Molecular Structure; D010453:Peptide Synthases / Q000037:antagonists & inhibitors*; D011099:Polyglutamic Acid / Q000031:analogs & derivatives* / Q000378:metabolism; D011624:Pteroylpolyglutamic Acids / Q000378:metabolism*; D013329:Structure-Activity Relationship; D011623:gamma-Glutamyl Hydrolase / Q000037:antagonists & inhibitors*
D005493:Folic Acid Antagonists; D011624:Pteroylpolyglutamic Acids; D011099:Polyglutamic Acid; C014085:methotrexate polyglutamate; D011623:gamma-Glutamyl Hydrolase; D010453:Peptide Synthases; C023103:folylpolyglutamate synthetase; D008727:Methotrexate