In vitro and in vivo genotoxicity evaluation of hormonal drugs. II. Dexamethasone.
Genotoxicity evaluation of a widely used glucocorticoid medicine, dexamethasone, was undertaken using in vitro and in vivo assays. Analyses of chromosomal aberrations, sister-chromatid exchanges (SCEs) in human lymphocytes and micronuclei and SCEs in mouse bone marrow showed the drug to be capable of attacking the genetic material. However, the Ames/Salmonella assay, both with and without S9 mix, did not show any increase in His+ revertants.
Singh
H
H
Department of Human Genetics, Guru Nanak Dev University, Amritsar, India.
Singh
J R
JR
Dhillon
V S
VS
Bali
D
D
Paul
H
H
D000818:Animals; D001711:Biotransformation; D002869:Chromosome Aberrations; D003907:Dexamethasone / Q000633:toxicity*; D006801:Humans; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009152:Mutagenicity Tests; D009153:Mutagens; D012485:Salmonella typhi / Q000187:drug effects; D012854:Sister Chromatid Exchange
D009153:Mutagens; D003907:Dexamethasone