[Cryohemosorption--a method of removal of lipoprotein-antibody immune complexes and other atherogenic substances in patients with atherosclerosis].
The efficacy of extracorporeal cryohemosorption was estimated in the treatment of atherosclerotic patients in terms of the autoimmune theory of the pathogenesis of this disease. There was a slight decrease in the plasma levels of total cholesterol and triglycerides, there was over 2-fold reduction in the plasma levels of fibrinogen and fibronectin. All major components of apo B-containing lipoproteins and immunoglobulin G were found as part of the cryoprecipitate. An extremely high concentration of lipid hydroperoxides in the precipitate suggest that cryoprecipitation removes not only autoimmune complexes, but highly-atherogenic peroxide-modified lipoproteins. The three-fold decrease in the levels of lipoprotein-antibody complexes resulted in lower atherogenicity of apo B-containing lipoproteins. It is suggested that the mechanism responsible for beneficial clinical action of cryohemosorption sessions is largely associated with the removal of autoimmune lipoprotein-antibody complexes and peroxide-modified apo B-containing lipoproteins than correction of lipid metabolism.
Klimov
A N
AN
Denisenko
A D
AD
Belotserkovskiĭ
M V
MV
Gurevich
K Ia
KIa
Vinogradov
A G
AG
Makoveĭchuk
E G
EG
Vasil'eva
L E
LE
Oleĭnik
I A
IA
Tikhonova
L N
LN
Sitnikova
O D
OD
D000328:Adult; D000368:Aged; D000936:Antigen-Antibody Complex; D001053:Apolipoproteins / Q000032:analysis; D001161:Arteriosclerosis / Q000097:blood / Q000276:immunology / Q000628:therapy*; D001323:Autoantibodies / Q000276:immunology*; D001327:Autoimmune Diseases; D002784:Cholesterol / Q000097:blood; D005069:Evaluation Studies as Topic; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005353:Fibronectins / Q000032:analysis; D006464:Hemoperfusion; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D008074:Lipoproteins / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood
D000936:Antigen-Antibody Complex; D001053:Apolipoproteins; D001323:Autoantibodies; D005353:Fibronectins; D007074:Immunoglobulin G; D008074:Lipoproteins; D014280:Triglycerides; D005340:Fibrinogen; D002784:Cholesterol