[The molecular aspects of the action of the radioprotector indralin].
The effect of indralin on the metabolic parameters in peripheral blood and organs of irradiated dogs and mice have been studied by EPR, NMR and radioisotope methods. It has been shown that indralin stimulated biosynthesis of DNA precursors as well as of DNA and proteins in the organs and stabilized the rate of ATP and glycogen synthesis. As a result indralin reduced considerably the changes produced by gamma-irradiation on the macromolecular biosynthesis during the early post-irradiation period. Indralin has induced marked favorable changes in the rate of macromolecular synthesis, normalized the ATP and glycogen content, induced ribonucleotide reductase activity and increased the Fe(3+)-transferrin content during development of compensatory-repair response in the irradiated animals. Indralin prevented hyperdevelopment of the repair response and its breakdown due to radiation-induced exhaustion of viability of many important cellular and body systems after irradiation with lethal doses.
Chernov
G A
GA
Shliakova
T G
TG
Sharygin
V L
VL
Sharf
V G
VG
Todorov
I N
IN
Mitrokhin
Iu I
IuI
Efremova
O I
OI
Khristianovich
D S
DS
Rozantseva
T V
TV
Pulatova
M K
MK
D000818:Animals; D004247:DNA / Q000096:biosynthesis / Q000737:chemistry / Q000528:radiation effects; D004285:Dogs; D004307:Dose-Response Relationship, Radiation; D004353:Drug Evaluation, Preclinical; D004578:Electron Spin Resonance Spectroscopy; D004734:Energy Metabolism / Q000187:drug effects; D005260:Female; D005720:Gamma Rays; D046911:Macromolecular Substances; D008297:Male; D051379:Mice; D010636:Phenols / Q000494:pharmacology* / Q000627:therapeutic use; D014176:Protein Biosynthesis; D011506:Proteins / Q000737:chemistry / Q000528:radiation effects; D012313:RNA / Q000096:biosynthesis / Q000737:chemistry / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000378:metabolism / Q000517:prevention & control; D011837:Radiation-Protective Agents / Q000494:pharmacology* / Q000627:therapeutic use
D046911:Macromolecular Substances; D010636:Phenols; D011506:Proteins; D011837:Radiation-Protective Agents; C086896:indralin; D012313:RNA; D004247:DNA