title: MR imaging of regional cardiac function: low-pass filtering of wall thickness curves.
abstract: Wall thickness curves (WTCs) derived from MR images are subject to considerable measurement error. This study determines the effects of low-pass Fourier filtering of WTCs on functional parameters derived from the curve: peak rate of wall thinning (PRWT) and time to PRWT (TPRWT). The inter-subject standard deviation (SD) of PRWT changed from 0.35 to 0.18, and the SD of TPRWT from 34.3 to 29.5. Differences between neighboring segments decreased from 0.31 to 0.15% mean thickness/ms for PRWT (P = 0.012), and from 35.0 to 19.0 ms for TPRWT (P = 0.005). It is concluded that filtering of MR imaging-derived WTCs contributes to a better representation of myocardial wall motion.
authors.affiliation: Department of Diagnostic Radiology, University Hospital Leiden, The Netherlands.
authors.forename: H J
authors.initials: HJ
authors.lastname: Lamb
authors.forename: R R
authors.initials: RR
authors.lastname: Singleton
authors.forename: R J
authors.initials: RJ
authors.lastname: van der Geest
authors.forename: G M
authors.initials: GM
authors.lastname: Pohost
authors.forename: A
authors.initials: A
authors.lastname: de Roos
mesh_terms: D000328:Adult; D005260:Female; D006321:Heart / Q000033:anatomy & histology* / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000379:methods*; D008297:Male; D008875:Middle Aged