Argyrophilic thread-like structure in corticobasal degeneration and supranuclear palsy.
Massive argyrophilic thread-like structures (ATS) are observed in corticobasal degeneration and, in varied degrees, in some cases of progressive supranuclear palsy. Immunohistochemically, ATS has a full length of phosphorylated tau epitopes without ubiquitin. Gallyas- and immuno-electron microscopic observation revealed that ATS is a cytoskeletal abnormality occurred in both the inner and outer loop of the oligodendroglia. tau-Positive oligodendroglial tangles were distributed in the same region as ATS.
Ikeda
K
K
Department of Neuropathology, Tokyo Institute of Psychiatry, Japan.
Akiyama
H
H
Haga
C
C
Kondo
H
H
Arima
K
K
Oda
T
T
D000368:Aged; D001479:Basal Ganglia / Q000473:pathology*; D002540:Cerebral Cortex / Q000473:pathology*; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D009410:Nerve Degeneration; D013494:Supranuclear Palsy, Progressive / Q000473:pathology*; D016875:tau Proteins / Q000378:metabolism
D000939:Epitopes; D016875:tau Proteins