title: Chronic effect of the irreversible and reversible selective MAO-A inhibitors on rat pineal melatonin biosynthesis.
abstract: Acute administration of the irreversible MAO-A inhibitor, clorgyline (2.0 mg/kg, s.c.) and the reversible MAO-A inhibitor, moclobemide (10 mg/kg, s.c.), increased rat pineal melatonin and related indoles content (HPLC-fluorimetric method). Chronic (21 days) administration of clorgyline attenuated the acute effect of clorgyline on pineal melatonin biosynthesis. The acute effect of moclobemide on melatonin biosynthesis was not affected by chronic moclobemide administration. The observed difference in the chronic effects of irreversible and reversible selective MAO-A inhibitors on melatonin biosynthesis could have clinical implications.
authors.affiliation: Pineal Research Laboratory, VAMC, Providence, Rhode Island.
authors.forename: G F
authors.initials: GF
authors.lastname: Oxenkrug
authors.forename: P J
authors.initials: PJ
authors.lastname: Requintina
authors.forename: I M
authors.initials: IM
authors.lastname: McIntyre
authors.forename: K
authors.initials: K
authors.lastname: White
mesh_terms: D000818:Animals; D001549:Benzamides / Q000008:administration & dosage / Q000494:pharmacology; D003010:Clorgyline / Q000008:administration & dosage / Q000494:pharmacology; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008550:Melatonin / Q000096:biosynthesis*; D020912:Moclobemide; D008995:Monoamine Oxidase / Q000378:metabolism*; D008996:Monoamine Oxidase Inhibitors / Q000008:administration & dosage* / Q000494:pharmacology; D010870:Pineal Gland / Q000378:metabolism*; D051381:Rats; D011916:Rats, Inbred F344; D012701:Serotonin / Q000031:analogs & derivatives / Q000378:metabolism; D013997:Time Factors
chemical_list: D001549:Benzamides; D008996:Monoamine Oxidase Inhibitors; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008995:Monoamine Oxidase; D008550:Melatonin; D003010:Clorgyline; C006389:N-acetylserotonin; D020912:Moclobemide