Effect of terfenadine on substance P and vasoactive intestinal polypeptide concentrations in nasal secretions from patients with nasal allergy.
Before terfenadine treatment, the mean substance P and vasoactive intestinal polypeptide (VIP) concentrations in nasal secretions from nasal allergy patients tended to be higher than the values of healthy subjects. During terfenadine treatment, the mean substance P concentrations in nasal secretions from patients allergic to house dust or pollen were significantly decreased to 62 and 39% of the initial values, respectively. The mean VIP concentrations in nasal secretions from the house dust allergy patients and the pollen allergy patients were significantly decreased to 52 and 18% of the initial values, respectively. Plasma substance P and VIP concentrations were not affected by nasal allergic symptom and terfenadine treatment.
Takeyama
M
M
Department of Clinical Pharmacy, Oita Medical University, Japan.
Mori
K
K
Morikawa
N
N
Asakura
S
S
Chaen
T
T
Watanabe
N
N
Mogi
G
G
D000293:Adolescent; D000328:Adult; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D007124:Immunoenzyme Techniques; D009297:Nasal Mucosa / Q000187:drug effects* / Q000378:metabolism; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy* / Q000378:metabolism; D006255:Rhinitis, Allergic, Seasonal / Q000188:drug therapy* / Q000378:metabolism; D013373:Substance P / Q000378:metabolism*; D016593:Terfenadine / Q000494:pharmacology*; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D016593:Terfenadine