title: Alteration by Iloprost of the vasospastic effects of endothelin-1 in rabbit cerebral vessels.
abstract: The reversal of endothelin-1 induced cerebral vasospasm with Iloprost was studied in the rabbit. Vasospasm in the basilar artery was evaluated by angiography; cerebral ischaemia by 'red-neurone-count' on light microscopy and morphological changes by electron microscopy. A potent antagonistic effect of Iloprost against ET-1 was observed in each of the parameters measured.
authors.affiliation: Department of Neurosurgery, Gazi University Faculty of Medicine, Ankara, Turkey.
authors.forename: I S
authors.initials: IS
authors.lastname: Keskil
authors.forename: M K
authors.initials: MK
authors.lastname: Baykaner
authors.forename: H
authors.initials: H
authors.lastname: Sencer
authors.forename: O
authors.initials: O
authors.lastname: Ataoğlu
authors.forename: E
authors.initials: E
authors.lastname: Ilgit
authors.forename: B
authors.initials: B
authors.lastname: Erdoğan
authors.forename: N
authors.initials: N
authors.lastname: Ceviker
authors.forename: Z S
authors.initials: ZS
authors.lastname: Ercan
mesh_terms: D000818:Animals; D001488:Basilar Artery / Q000473:pathology / Q000648:ultrastructure; D001921:Brain / Q000473:pathology / Q000648:ultrastructure; D002533:Cerebral Angiography; D016232:Endothelins / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D005260:Female; D016285:Iloprost / Q000008:administration & dosage / Q000494:pharmacology*; D007269:Injections, Intra-Arterial; D002546:Ischemic Attack, Transient / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D008297:Male; D009474:Neurons / Q000187:drug effects / Q000648:ultrastructure; D011817:Rabbits; D013345:Subarachnoid Hemorrhage / Q000473:pathology
chemical_list: D016232:Endothelins; D016285:Iloprost