Immediate adverse reaction to aminophylline.
We present a patient who experienced an immediate adverse reaction following intravenous administration of aminophylline. Skin prick, intradermal, and patch tests, RAST and indirect ELISA assays with aminophylline, theophylline and ethylenediamine were negative. A positive histamine release test was found only with ethylenediamine. Single-blind placebo-controlled challenges were positive with aminophylline and negative with theophylline. Our results suggest the reaction was a type I hypersensitivity reaction to ethylenediamine, but a nonimmune mechanism could not be excluded.
de la Hoz
B
B
Department of Allergy, General Hospital, Albacete, Spain.
Pérez
C
C
Tejedor
M A
MA
Lázaro
M
M
Salazar
F
F
Cuevas
M
M
D000284:Administration, Oral; D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology; D004342:Drug Hypersensitivity / Q000209:etiology*; D005029:Ethylenediamines / Q000276:immunology; D005260:Female; D006636:Histamine Release; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007114:Immunization; D009532:Nickel / Q000009:adverse effects; D012882:Skin Tests
D005029:Ethylenediamines; D000628:Aminophylline; C031234:ethylenediamine; D009532:Nickel