[The effect of the neuropeptide galanin on active avoidance in rats].
Administration of galanin into the lateral brain ventricles induced a dose-dependent impairment of memory in the active avoidance test in rats. Atropine both induced the impairment of memory and potentiated the galanin amnestic effect. Naloxone had no such action as well as ketamine. Galanin seems to impair memory via suppressing cholinergic and activating opioid peptidergic transmission in the CNS.
Shandra
A A
AA
Mazarati
A M
AM
Servetskiĭ
K L
KL
D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001362:Avoidance Learning / Q000187:drug effects* / Q000502:physiology; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005108:Extinction, Psychological / Q000187:drug effects / Q000502:physiology; D019004:Galanin; D007649:Ketamine / Q000494:pharmacology; D008297:Male; D008568:Memory / Q000187:drug effects / Q000502:physiology; D009270:Naloxone / Q000494:pharmacology; D009479:Neuropeptides / Q000008:administration & dosage / Q000494:pharmacology*; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012054:Reinforcement, Psychology
D009479:Neuropeptides; D010455:Peptides; D009270:Naloxone; D007649:Ketamine; D001285:Atropine; D019004:Galanin