[The role of arginine-vasopressin and substance P in the pathogenesis of hypertension and their interrelation].
In this study, the concentration of plasma arginine vasopressin (AVP) and substance P (SP) in normotensive subjects as well as patients with essential hypertension was measured. The results showed that: (1) The concentration of plasma AVP in patients with essential hypertension (21.83 +/- 1.30ng/L) was significantly higher than that in normotensive subjects (11.02 +/- 1.05 ng/L) (P < 0.001). The level of plasma SP in hypertensive subjects (276.60 +/- 21.35 pmol/L) was obviously lower than that in normotensive subjects (958.20 +/- 31.13 pmol/L) (P < 0.001). (2) The level of plasma AVP decreased (from 24.88 +/- 1.63 to 8.69 +/- 1.39 ng/L, P < 0.001) and that of plasma SP increased (from 331.40 +/- 48.18 to 958.80 +/- 39.30 pmol/L, P < 0.001) after antihypertensive drug treatment. (3) A negative correlation was found between the level of plasma AVP and SP in patients with essential hypertension (r = -0.564, P < 0.001), but no correlation was found between them in normotensive subjects (r = -0.096, P > 0.05). It is suggested that the abnormal level of plasma AVP and SP plays a role in the pathogenesis of hypertension.
Cao
S P
SP
Department of Cardiology, Tang Du Hospital, Fourth Military Medical University, Xi'an.
Zhao
L Y
LY
D000328:Adult; D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001127:Arginine Vasopressin / Q000502:physiology*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000188:drug therapy / Q000209:etiology; D008297:Male; D008875:Middle Aged; D013373:Substance P / Q000502:physiology*
D000959:Antihypertensive Agents; D001127:Arginine Vasopressin; D013373:Substance P