Platelet aggregation in response to four low molecular weight heparins and the heparinoid ORG 10172 in patients with heparin-induced thrombocytopenia.
A simple rapid platelet aggregation test was used to evaluate cross-reactivity of four low molecular weight heparins and the heparinoid ORG 10172 in three patients with heparin-induced thrombocytopenia. The low molecular weight heparins cross-reacted in 11 out of 12 tests. The heparinoid ORG 10172 did not cross-react in any of the patients. One patient was treated with ORG 10172 and thrombocytopenia resolved.
Keeling
D M
DM
Department of Haematology, Adenbrooke's Hospital, Cambridge.
Richards
E M
EM
Baglin
T P
TP
D000328:Adult; D000368:Aged; D000925:Anticoagulants / Q000494:pharmacology*; D002809:Chondroitin Sulfates; D003429:Cross Reactions; D003871:Dermatan Sulfate; D005260:Female; D006025:Glycosaminoglycans / Q000494:pharmacology*; D006493:Heparin / Q000009:adverse effects; D006495:Heparin, Low-Molecular-Weight / Q000494:pharmacology*; D006496:Heparinoids / Q000494:pharmacology; D006497:Heparan Sulfate; D006801:Humans; D010974:Platelet Aggregation / Q000187:drug effects*; D013921:Thrombocytopenia / Q000139:chemically induced*
D000925:Anticoagulants; D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D006025:Glycosaminoglycans; D006493:Heparin; D006495:Heparin, Low-Molecular-Weight; D006496:Heparinoids; D006497:Heparan Sulfate; C035838:danaparoid