[The physiological role of the structural-functional changes in the air-blood barrier of the lungs in supplying the body with oxygen under the action of extreme factors].
Hypoxic states, under the effect of extreme factors, induced changes in the endothelium of the lung capillaries irrespective of the nature of the factors (exo- or endogenous) causing the hypoxic state. Significant changes of the mitochondrial apparatus of the lung air-blood barrier cells occurred in the hypoxic hypoxia. The data obtained suggest that the thickness of the ABB, under extreme conditions, cannot serve as a parameter of the morphofunctional state of the lung ABB. The compensatory-adaptive response of the cell structures seem to decrease the oxygen diffusion from the alveolar gas into the blood of the lung capillaries.
Seredenko
M M
MM
Rozova
E V
EV
D000531:Altitude; D000818:Animals; D015824:Blood-Air Barrier / Q000502:physiology*; D006470:Hemorrhage / Q000473:pathology / Q000503:physiopathology; D000860:Hypoxia / Q000473:pathology / Q000503:physiopathology*; D008168:Lung / Q000503:physiopathology* / Q000648:ultrastructure; D008297:Male; D008854:Microscopy, Electron; D009584:Nitrogen / Q000008:administration & dosage; D010100:Oxygen / Q000008:administration & dosage / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar
C041364:nitrox; D009584:Nitrogen; D010100:Oxygen