T cell vaccination in multiple sclerosis: hopes and facts.
Six MS-patients were inoculated three times with autologous attenuated MBP-specific T cell clones at two month intervals. No toxic effects were observed. After the third inoculation the precursor frequency of the MBP-specific T cells dropped to undetectable levels in all patients. Injection of attenuated MBP-specific T cells gave rise to a pronounced response of anti-clonotypic T cells and a limited anti-ergotypic response. The anti-clonotypic T cells proliferated in the presence of the vaccine clones and were inhibitory and cytotoxic for the same vaccine clones. This clinical trial shows for the first time that antigen specific T cell vaccination in humans is feasible. The results obtained are highly promising for future treatments of Multiple Sclerosis and other autoimmune diseases.
Zhang
J
J
Dr. L. Willems Instituut, Diepenbeek.
Raus
J
J
D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D009103:Multiple Sclerosis / Q000628:therapy*; D004676:Myelin Basic Protein / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology / Q000637:transplantation*; D014182:Transplantation, Autologous; D014611:Vaccination
D004676:Myelin Basic Protein