title: [Interferon-induced retinal changes].
abstract: Fifty patients treated with interferon for chronic type C hepatitis, chronic type B hepatitis and renal cell carcinoma were examined for retinal complications. Retinal hemorrhages or cotton wool spots were observed in 23 (46%) of the patients. Retinal hemorrhages without cotton wool spots were found in 14 patients, cotton wool spots without retinal hemorrhages in 5 patients, and both hemorrhages and cotton wool spots in four patients. These findings were potentially reversible. There was one case of branch retinal artery occlusion and one case with microaneurysm. Red blood cell count decreased significantly in the patients with retinopathy compared with those without retinopathy (p < 0.05%). Patients with diabetes, hypertension, retinal arterial sclerosis, and anemia were at risk for retinopathy.
authors.affiliation: Department of Ophthalmology, Koga General Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Chuman
authors.forename: N
authors.initials: N
authors.lastname: Nao-i
authors.forename: A
authors.initials: A
authors.lastname: Sawada
authors.forename: T
authors.initials: T
authors.lastname: Kawano
authors.forename: M
authors.initials: M
authors.lastname: Shigehira
mesh_terms: D002292:Carcinoma, Renal Cell / Q000628:therapy; D005260:Female; D006509:Hepatitis B / Q000628:therapy; D006526:Hepatitis C / Q000628:therapy; D006801:Humans; D007372:Interferons / Q000009:adverse effects*; D007680:Kidney Neoplasms / Q000628:therapy; D008297:Male; D008875:Middle Aged; D012164:Retinal Diseases / Q000209:etiology*; D012166:Retinal Hemorrhage / Q000209:etiology
chemical_list: D007372:Interferons