Angiogenesis inhibition: a review.
In this review we discuss the concept of anti-angiogenesis, which is the inhibition of neovascularization. Anti-angiogenic agents are viewed from the standpoint of their effect on various elements of the angiogenic process, including induction of vascular discontinuity, endothelial cell movement, endothelial cell proliferation, and three-dimensional restructuring of patent vessels. An effort is made to place the many different approaches to anti-angiogenesis research into a comprehensible structure, in order to identify problems of evaluation and interpretation, thereby providing a clearer basis for determining promising and needed directions for further investigation.
Auerbach
W
W
Center for Developmental Biology, University of Wisconsin, Madison 53706.
Auerbach
R
R
D000818:Animals; D001485:Basement Membrane / Q000378:metabolism; D002450:Cell Communication; D002455:Cell Division / Q000187:drug effects; D002465:Cell Movement / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D006801:Humans; D009389:Neovascularization, Pathologic / Q000517:prevention & control*