Sweet's syndrome associated with G-CSF.
Sweet's syndrome (SS) developed in two patients with acute myeloid leukaemia (AML) treated with granulocyte colony stimulating factor (G-CSF) for febrile neutropenia due to AML chemotherapy. Fever, painful skin and conjunctival lesions developed and neutrophilic infiltration was detected at biopsy specimens. Neutrophilia was not detected. Skin lesions regressed within 1-2 weeks and conjunctival lesions within 4 weeks following the cessation of G-CSF. We conclude that SS may be a complication of G-CSF therapy and tender skin and/or conjunctival lesions developing during G-CSF therapy should suggest the possibility of SS.
Paydaş
S
S
Department of Oncology, Cukurova University Faculty of Medicine, Balcali, Adana, Turkey.
Sahin
B
B
Seyrek
E
E
Soylu
M
M
Gonlusen
G
G
Acar
A
A
Tuncer
I
I
D000208:Acute Disease; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy; D016463:Sweet Syndrome / Q000139:chemically induced*
D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor