Antigenic analysis of hematopoiesis: a review.
The ability to immunophenotype the heterogeneous populations of cells within bone marrow has given investigators the tools to identify, enumerate, and isolate cells of any lymphohematopoietic lineage. These cells can, in turn, be studied in morphologic, growth, biochemical, and molecular biological assays, and used for clinical transplantation, with or without in vitro expansion. Although the map of normal marrow lymphohematopoiesis has been largely determined, there is still some controversy regarding the identity and maturation pathways of lymphohematopoietic progenitors and stem cells. The currently available information on this area is reviewed and interpreted in this article.
Civin
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Division of Pediatric Oncology, Johns Hopkins Oncology Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287-5001.
Gore
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D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D018952:Antigens, CD34; D000943:Antigens, Differentiation / Q000032:analysis; D015415:Biomarkers; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D004253:DNA Nucleotidylexotransferase; D015672:Erythroid Precursor Cells / Q000166:cytology; D006684:HLA-DR Antigens / Q000032:analysis; D006410:Hematopoiesis / Q000276:immunology*; D006412:Hematopoietic Stem Cells / Q000166:cytology / Q000276:immunology; D006801:Humans; D016130:Immunophenotyping; D008562:Membrane Glycoproteins
D015703:Antigens, CD; D018952:Antigens, CD34; D000943:Antigens, Differentiation; D015415:Biomarkers; D006684:HLA-DR Antigens; D008562:Membrane Glycoproteins; D004253:DNA Nucleotidylexotransferase; D036541:ADP-ribosyl Cyclase; C498154:CD38 protein, human; D051997:ADP-ribosyl Cyclase 1