title: Novel microbial metabolites of the phoslactomycins family induce production of colony-stimulating factors by bone marrow stromal cells. I. Taxonomy, fermentation and biological properties.
abstract: Three metabolites were isolated from the culture broth of an actinomycete strain identified as Streptomyces platensis SANK 60191, that induce the production of colony-stimulating factors (CSFs) by stromal cell line KM-102 at ED50 concentrations from 40 to 200 ng/ml. The compounds induced quantities of granulocyte CSF (G-CSF) and granulocyte-macrophage CSF (GM-CSF) comparable to those induced by interleukin-1, a strong CSF inducer. These metabolites were called leustroducsins (A, B and C) and were later found to be structurally related to phoslactomycins. This is the first report of CSF inducing activity by members of the phoslactomycin class.
authors.affiliation: Bioscience Research Laboratories, Sankyo Co., Ltd., Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kohama
authors.forename: R
authors.initials: R
authors.lastname: Enokita
authors.forename: T
authors.initials: T
authors.lastname: Okazaki
authors.forename: H
authors.initials: H
authors.lastname: Miyaoka
authors.forename: A
authors.initials: A
authors.lastname: Torikata
authors.forename: M
authors.initials: M
authors.lastname: Inukai
authors.forename: I
authors.initials: I
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Kagasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Sakaida
authors.forename: A
authors.initials: A
authors.lastname: Satoh
mesh_terms: D000935:Antifungal Agents / Q000494:pharmacology; D001853:Bone Marrow / Q000187:drug effects* / Q000378:metabolism; D002460:Cell Line; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D009943:Organophosphorus Compounds / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D011753:Pyrones; D013302:Streptomyces / Q000737:chemistry*; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D007783:Lactones; D009943:Organophosphorus Compounds; D011753:Pyrones; D016179:Granulocyte Colony-Stimulating Factor; C084413:leustroducsin A; C084414:leustroducsin B; C084415:leustroducsin C; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; C038752:leptomycin A