Possible link between anaphylactoid reactions to anaesthetics and chemicals in cosmetics and biocides.
Binding-inhibition studies involving human IgE antibody to suxamethonium, SUX (from a patient with a near-fatal reaction), were performed with five different quaternary ammonium compounds (QAC): three common ingredients of cosmetics and two commonly used disinfectants, cetrimide and benzalkonium. All the five QAC showed immunological cross-reaction with SUX. In addition, at high concentrations, they released histamine from basophils of normal subjects. Thus, QAC may be both sensitizers and histamine releasers.
Weston
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Pharmacology Department, University College London, UK.
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D000707:Anaphylaxis / Q000503:physiopathology*; D000777:Anesthetics / Q000009:adverse effects* / Q000276:immunology; D003358:Cosmetics / Q000009:adverse effects*; D003429:Cross Reactions; D004202:Disinfectants / Q000009:adverse effects* / Q000276:immunology; D006241:Haptens / Q000276:immunology; D006636:Histamine Release / Q000187:drug effects; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology; D009466:Neuromuscular Blocking Agents / Q000009:adverse effects; D011852:Radioallergosorbent Test
D000777:Anesthetics; D003358:Cosmetics; D004202:Disinfectants; D006241:Haptens; D009466:Neuromuscular Blocking Agents; D007073:Immunoglobulin E