Regulation of interleukin-5 production by peripheral blood mononuclear cells from atopic patients with FK506, cyclosporin A and glucocorticoid.
Upon stimulation with phorbol ester and ionomycin, peripheral blood mononuclear cells (PBMC) of atopic patients with moderate eosinophilia produced significantly higher amounts of IL-5 compared to that of normal subjects. This finding renders further support to the notion that T cell-eosinophilic inflammation plays a central role in allergic disorders. IL-5 induction in vitro was completely inhibited by immunosuppressant FK506, cyclosporin A and dexamethasone. FK506 applied in vivo effectively suppressed clinical symptoms of atopic dermatitis and IL-5 production of PBMC. FK506 and cyclosporin A may become a better therapeutic modality against allergic diseases.
Mori
A
A
Department of Medicine, University of Tokyo, Faculty of Medicine, Japan.
Suko
M
M
Nishizaki
Y
Y
Kaminuma
O
O
Matsuzaki
G
G
Ito
K
K
Etoh
T
T
Nakagawa
H
H
Tsuruoka
N
N
Okudaira
H
H
D000287:Administration, Topical; D001249:Asthma / Q000276:immunology; D002118:Calcium / Q000494:pharmacology; D016572:Cyclosporine / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000097:blood* / Q000188:drug therapy; D015848:Interleukin-5 / Q000096:biosynthesis*; D007476:Ionophores / Q000494:pharmacology; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism*; D010703:Phorbol Esters / Q000494:pharmacology; D016559:Tacrolimus / Q000008:administration & dosage / Q000494:pharmacology*
D015848:Interleukin-5; D007476:Ionophores; D010703:Phorbol Esters; D003907:Dexamethasone; D016572:Cyclosporine; D002118:Calcium; D016559:Tacrolimus