[Synovial angiogenesis].
Synovial angiogenesis i.e. the formation of new capillaries from pre-existent capillaries, is a prominent feature of articular inflammation. Since its regulation is tightly controlled, angiogenesis should disappear after recovery from acute episode. However, it may persist in chronic synovial inflammation such as rheumatoid arthritis (RA). Thus RA should be considered as an "angiogenic disease". This is the result of biochemical events which have contributed to the breakdown of the extracellular matrix and to the release of angiogenic factors in the local micro-environment. The growth of the pannus is dependent on the local angiogenesis which contributes to the destruction of joint cartilage. The development of inhibitors of synovial angiogenesis could offer a new therapeutic hope in RA.
Lioté
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F
Centre Viggo Petersen (clinique de rhumatologie et laboratoire d'histopathologie de la synoviale) hôpital Lariboisière, Paris.
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000503:physiopathology / Q000628:therapy; D006801:Humans; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D010003:Osteoarthritis / Q000503:physiopathology; D013583:Synovial Membrane / Q000098:blood supply*