title: Preferential inhibition of inducible nitric oxide synthase by ebselen.
abstract: Ebselen, 2-phenyl-1,2-benzisoselenazole-3(2H)-one can preferentially inhibit the activity of inducible nitric oxide (NO) synthase with little inhibition of endothelial constitutive NO synthase within a certain concentration range. This suggests that ebselen deserves further in vivo studies to examine its possible application to the therapy of septic shock where inducible NO synthase is responsible for vasodilation.
authors.affiliation: Department of Internal Medicine, Faculty of Medicine, Kyoto University, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Hattori
authors.forename: R
authors.initials: R
authors.lastname: Inoue
authors.forename: K
authors.initials: K
authors.lastname: Sase
authors.forename: H
authors.initials: H
authors.lastname: Eizawa
authors.forename: K
authors.initials: K
authors.lastname: Kosuga
authors.forename: T
authors.initials: T
authors.lastname: Aoyama
authors.forename: H
authors.initials: H
authors.lastname: Masayasu
authors.forename: C
authors.initials: C
authors.lastname: Kawai
authors.forename: S
authors.initials: S
authors.lastname: Sasayama
authors.forename: Y
authors.initials: Y
authors.lastname: Yui
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D002417:Cattle; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology; D004790:Enzyme Induction; D054833:Isoindoles; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000201:enzymology; D019001:Nitric Oxide Synthase; D016566:Organoselenium Compounds / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000975:Antioxidants; D001393:Azoles; D054833:Isoindoles; D016566:Organoselenium Compounds; C042986:ebselen; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases