title: The G gamma:A gamma ratios in the fetal hemoglobin of newborns of the Man ethnic group and their gamma-globin gene arrangements.
abstract: The G gamma:A gamma ratios of Hb F were determined in 331 newborn babies of the Man ethnic group in Liaoning Province, P.R. China, using polyacrylamide gel electrophoresis; in 27 cases they were also determined by reversed phase high performance liquid chromatography. The results showed that a high G gamma value (> 80%) was present in four cases (1.21%) and low G gamma values (30-48%) in six cases (1.81%); not a single case with the A gamma T [A gamma 75(E19)Ile->Thr] chain was found. Gene mapping analysis demonstrated that two babies with high G gamma values had the -G gamma-G gamma-/-G gamma-A gamma- (0.60%), and two others the -G gamma-AG gamma-A gamma-/-G gamma-A gamma- (0.60%) arrangements. Two of the four babies with low G gamma values were identified as -A gamma-A gamma-/-G gamma-A gamma- (0.60%) and the other two as -GA gamma-/-G gamma-A gamma- (0.60%). The genotype -A gamma-A gamma- has not been reported before in Chinese.
authors.affiliation: Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing.
authors.forename: W D
authors.initials: WD
authors.lastname: Chen
authors.forename: P C
authors.initials: PC
authors.lastname: Jia
authors.forename: S S
authors.initials: SS
authors.lastname: Chen
authors.forename: C C
authors.initials: CC
authors.lastname: Liang
authors.forename: B S
authors.initials: BS
authors.lastname: Wang
authors.forename: S
authors.initials: S
authors.lastname: Gao
authors.forename: X J
authors.initials: XJ
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Wang
authors.forename: S K
authors.initials: SK
authors.lastname: Qu
mesh_terms: D044466:Asian People / Q000235:genetics*; D002681:China; D002874:Chromosome Mapping; D005006:Ethnicity; D005319:Fetal Hemoglobin / Q000235:genetics*; D015321:Gene Rearrangement; D005914:Globins / Q000032:analysis / Q000235:genetics*; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*
chemical_list: D005914:Globins; D005319:Fetal Hemoglobin