Radioprotective effect of stobadine in the mouse micronucleus test.
Induction of micronuclei was studied 40 h post irradiation in peripheral blood reticulocytes of male mice treated or not with stobadine dipalmitate (70.07 mg/kg body weight) at two time intervals (2 h or 1 h) prior to and immediately after 6.5 Gy 60Co exposure. A significant decrease of micronucleated reticulocytes was observed in the group of mice pretreated 2 h (P < 0.05) or 1 h (P < 0.01) before irradiation. 60Co irradiation followed by treatment with stobadine did not lead to the same protective effect in the micronucleus assay. It is therefore assumed that a radical-scavenging mechanism must be involved in radioprotection by stobadine.
Chorvatovicová
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Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D002243:Carbolines / Q000494:pharmacology*; D003037:Cobalt Radioisotopes / Q000633:toxicity*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015162:Micronucleus Tests; D016296:Mutagenesis / Q000187:drug effects*; D011837:Radiation-Protective Agents; D012156:Reticulocytes / Q000528:radiation effects
D000975:Antioxidants; D002243:Carbolines; D003037:Cobalt Radioisotopes; D011837:Radiation-Protective Agents; C100106:dicarbine