title: Bone formation markers and pain palliation in bone metastases treated with strontium-89.
abstract: In several bone disorders, including those with metastatic involvement, changes in procollagen type I C-terminal and type III N-terminal peptides are detected, as indications of altered bone metabolism. Assessment of bone turnover could play a role in the evaluation of response to Strontium-89 used as palliative treatment in symptomatic bone metastases from various primary tumors. A correlation between bone formation rate markers procollagen I and III and efficacy of ionic Strontium-89 was shown in a group of 13 patients who underwent treatment with 4 mCi of Strontium-89 for painful bone metastases: 5 from breast, 7 from prostate, and 1 from lung carcinoid cancer. Assessed as a modification of analgesic intake, pain, and ambulation, there were 6 complete remissions, 3 partial remissions, and 4 nonresponders. The duration of the response was from 2 to 11 months. Procollagen I and III levels were found to be highly abnormal in those with no benefit from Strontium-89 administration but were in the normal range or only slightly elevated in those achieving complete or partial pain control, thus correlating with the clinical response.
authors.affiliation: Radiotherapy Department, Casa Sollievo Sofferenza, San Giovanni R, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Guerrieri
authors.forename: S
authors.initials: S
authors.lastname: Modoni
authors.forename: S
authors.initials: S
authors.lastname: Parisi
authors.forename: V
authors.initials: V
authors.lastname: Fusco
authors.forename: V
authors.initials: V
authors.lastname: Oriolo
authors.forename: G
authors.initials: G
authors.lastname: Rendina
authors.forename: P G
authors.initials: PG
authors.lastname: Paleani-Vettori
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015519:Bone Density / Q000528:radiation effects*; D001859:Bone Neoplasms / Q000503:physiopathology / Q000532:radiotherapy* / Q000556:secondary; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010166:Palliative Care / Q000379:methods*; D013326:Strontium Radioisotopes / Q000627:therapeutic use*
chemical_list: D013326:Strontium Radioisotopes