Host cell antigenic profile acquired by HIV-1 is a marker of its cellular origin.
HIV-1 acquires cell membrane proteins during budding. The cell membrane proteins (CMP) profile of laboratory HIV-1 strains grown in different host cells was established, by using an immobilized antibody capture (IAC), to verify whether CMPs present on HIV-1 correlate with its host cell origin. HIV-1 grown in different cell lines incorporates cell markers such as CD3, CD19, CD14, CD31 and IL 2-R, according to the distinctive expression of these antigens on the host cells. Furthermore, also T-tropic and monocytotropic HIV-1 strains display host cell specific markers, supporting the hypothesis that virus associated CMPs are a marker of host cell origin.
Abbate
I
I
Institute of Virology, University La Sapienza, Rome, Italy.
Capobianchi
M R
MR
Fais
S
S
Castilletti
C
C
Mercuri
F
F
Cordiali Fei
P
P
Ameglio
F
F
Dianzani
F
F
D015703:Antigens, CD / Q000378:metabolism; D002460:Cell Line; D002462:Cell Membrane / Q000276:immunology; D015488:HIV Antigens / Q000378:metabolism*; D015497:HIV-1 / Q000254:growth & development / Q000276:immunology*; D006801:Humans; D008565:Membrane Proteins / Q000378:metabolism*
D015703:Antigens, CD; D015488:HIV Antigens; D008565:Membrane Proteins