title: Prostaglandin D2, F2 alpha, E2, and E1 in early phase of experimental acute necrohemorrhagic pancreatitis in rats.
abstract: Changes in endogenous pancreas production of prostaglandins D2, F2 alpha, E2, and E1 in early stages of acute necrotizing pancreatitis induced by intraductal administration of 3.5% sodium taurocholate have been determined by radioimmunoassay of chromatographically purified tissue extracts. For this purpose 18 male Wistar rats were randomized in three groups: control, pancreatitis, and pancreatitis plus indomethacin. Pancreas tissue samples were obtained 5 min after pancreatitis induction. In the pancreatitis-induced group, prostaglandins D2, F2 alpha, and E2 show significantly increased tissue levels relative to the controls whereas prostaglandin E1 remains unmodified. These results suggest a role for series 2 prostaglandins in the earlier stages of pancreatitis.
authors.affiliation: Molecular Pathology Unit, CID-CSIC, Barcelona, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Closa
authors.forename: J
authors.initials: J
authors.lastname: Roselló-Catafau
authors.forename: L
authors.initials: L
authors.lastname: Fernández-Cruz
authors.forename: E
authors.initials: E
authors.lastname: Gelpí
mesh_terms: D000208:Acute Disease; D000527:Alprostadil / Q000096:biosynthesis; D000681:Amylases / Q000097:blood; D000818:Animals; D015237:Dinoprost / Q000096:biosynthesis; D015232:Dinoprostone / Q000096:biosynthesis; D006470:Hemorrhage / Q000150:complications*; D007213:Indomethacin / Q000494:pharmacology; D008049:Lipase / Q000097:blood; D008297:Male; D009336:Necrosis; D010179:Pancreas / Q000378:metabolism / Q000473:pathology; D010195:Pancreatitis / Q000139:chemically induced / Q000150:complications / Q000378:metabolism*; D015230:Prostaglandin D2 / Q000096:biosynthesis; D011453:Prostaglandins / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013656:Taurocholic Acid
chemical_list: D011453:Prostaglandins; D013656:Taurocholic Acid; D015237:Dinoprost; D008049:Lipase; D000681:Amylases; D000527:Alprostadil; D015232:Dinoprostone; D015230:Prostaglandin D2; D007213:Indomethacin