Effects of lindane exposure on rainbow trout (Oncorhynchus mykiss) immunity. II. In vitro restoration of antibody-secreting cells and lymphocyte proliferation activity by nitrogranulogen after in vivo immunosuppression due to lindane.
A dose-dependent immunomodulatory effect of Nitrogranulogen (NGG) was observed in vitro on antibody-secreting cells and lymphocyte proliferation in rainbow trout. Because different doses of lindane (10, 50 and 100 mg/kg, injected intraperitoneally) had a depressing effect on the same immune functions, the authors restored them using NGG in vitro.
Siwicki
A K
AK
Ichthyopathology and Immunology Laboratory, Inland Fisheries Institute, Piaseczno, Poland.
Dunier
M
M
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000921:Antibody-Producing Cells / Q000187:drug effects*; D002455:Cell Division / Q000187:drug effects / Q000276:immunology; D004305:Dose-Response Relationship, Drug; D017753:Ecosystem; D001556:Hexachlorocyclohexane / Q000037:antagonists & inhibitors / Q000633:toxicity*; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology; D008466:Mechlorethamine / Q000494:pharmacology*; D017686:Oncorhynchus mykiss / Q000276:immunology*; D013154:Spleen / Q000187:drug effects* / Q000276:immunology
D008466:Mechlorethamine; D001556:Hexachlorocyclohexane