[Preventive effect of Rhodiolae rosea in spontaneous liver carcinogenesis in a mice model of high-tumor strain].
Different schemes of Rhodiolae rosea usage per os for prophylaxis of mouse hereditary hepatomas have been studied. A long-term effect on stimulation of tissue integration, T-immune activity and sufficient decrease of tumour frequency has been shown for R. rosea usage in early ontogenesis. A short-term effect on tissue and immune parameters has been demonstrated for R. rosea usage in middle ontogenesis. High-tumour frequency (as in the control), but tumour size decrease (comparing to the control) has been noticed in this case. A tendency to synchronic alterations of tissue integration and T-immune activity has been established in these experiments. It can be attributed to the assumption of communication between tissue (local) and immune (common) defence from tumour growth in the organism.
Bocharova
O A
OA
Serebriakova
R V
RV
Bodrova
N B
NB
D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D015994:Incidence; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000453:epidemiology / Q000276:immunology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D008954:Models, Biological; D010936:Plant Extracts / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013997:Time Factors
D010936:Plant Extracts