title: Proliferative advantage rather than classical drug resistance as the cause of treatment failure in chronic myelogenous leukemia.
abstract: This presentation discusses the role that proliferative advantage plays in making both the chronic and blastic phases of CML resistant to therapy. A case is made for the addition of "regrowth" inhibitors between courses of chemotherapy as a means of increasing the efficacy of therapy by suppressing or reducing the proliferative advantage that the target cells enjoy over those cells which one would like to repopulate the hematopoietic system.
authors.affiliation: Division of Hematology/Oncology, Rush Presbyterian-St. Luke's Medical Center, Chicago, IL 60612.
authors.forename: H D
authors.initials: HD
authors.lastname: Preisler
authors.forename: A
authors.initials: A
authors.lastname: Raza
authors.forename: M
authors.initials: M
authors.lastname: Baccarani
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001752:Blast Crisis / Q000188:drug therapy / Q000473:pathology; D002352:Carrier Proteins / Q000378:metabolism; D002455:Cell Division / Q000187:drug effects; D004351:Drug Resistance; D004357:Drug Synergism; D015973:Gene Expression Regulation, Leukemic / Q000187:drug effects; D016259:Genes, myc / Q000187:drug effects; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology / Q000627:therapeutic use; D007372:Interferons / Q000494:pharmacology / Q000627:therapeutic use; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000188:drug therapy* / Q000235:genetics / Q000473:pathology; D015466:Leukemia, Myeloid, Chronic-Phase / Q000188:drug therapy / Q000473:pathology; D008562:Membrane Glycoproteins / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D014411:Neoplastic Stem Cells / Q000187:drug effects / Q000473:pathology*; D012641:Selection, Genetic; D017211:Treatment Failure; D014212:Tretinoin / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D002352:Carrier Proteins; D007155:Immunologic Factors; D008562:Membrane Glycoproteins; D009363:Neoplasm Proteins; D014212:Tretinoin; D007372:Interferons