title: [The inhibition of Mycoplasma pneumoniae adhesion in a fetuin test system by synthetic analogs and polymeric forms of neuraminic acid].
abstract: Eight glycosides and structural analogues of neuraminic acid as well as eight polymeric forms of N-acetyl neuraminic acid have been studied for their inhibitory effect on adhesion of Mycoplasma pneumoniae. Maximum inhibiting effect among low-molecular compounds was manifested by 2-->3 sialyllactose which, being used in concentrations 5.0 and 10.0 micrograms/ml, inhibited adhesion of mycoplasmas by 76 and 87%, respectively. These indices for other derivatives in the above mentioned concentrations were as follows (%): 2-->6 sialyllactose, 31 and 74%; alpha-Me-glycoside NeuAc, 75 and 85%; alpha-Bn-glycoside-N-trifluoruracetyl NeuAc, 30 and 63%; alpha-Bn-glycoside NeuAc, 32 and 59%; alpha-Bn-glycoside-4-epi-NeuAc, 20 and 27%; beta-Bn-glycoside NeuAc, 2-4%; beta-me-glycoside NeuAc, 4-5%. The maximum inhibiting effect (50% inhibition at concentration 2.5 mumol) among polymeric forms was exerted by the conjugate alpha-benzeneglycoside with polyacrylic acid containing 12 mol% of NeuAc. Conjugates with 8, 16 and 20 mol% of NeuAc possessed a bit less activity. The 50% concentration for them was 5.3, 3.1 and 8.3 mumol, respectively. Polymeric forms on the basis of polyacrylamide proved less active.
authors.forename: I P
authors.initials: IP
authors.lastname: Tokovenko
authors.forename: I G
authors.initials: IG
authors.lastname: Skripal'
authors.forename: L P
authors.initials: LP
authors.lastname: Malinovskaia
authors.forename: N E
authors.initials: NE
authors.lastname: Baĭramova
authors.forename: L V
authors.initials: LV
authors.lastname: Mochalova
authors.forename: A B
authors.initials: AB
authors.lastname: Tuzikov
authors.forename: N V
authors.initials: NV
authors.lastname: Bovin
mesh_terms: D001422:Bacterial Adhesion / Q000187:drug effects*; D003864:Depression, Chemical; D007536:Isomerism; D008970:Molecular Weight; D009177:Mycoplasma pneumoniae / Q000187:drug effects* / Q000472:pathogenicity*; D009438:Neuraminic Acids / Q000494:pharmacology*; D011108:Polymers; D013329:Structure-Activity Relationship; D000509:alpha-Fetoproteins
chemical_list: D009438:Neuraminic Acids; D011108:Polymers; D000509:alpha-Fetoproteins