Molecular biologic investigations of proto-oncogenes and growth factors in human testicular tumors.
Molecular genetic alterations of known protoncogenes and growth factors, e.g. c-kit and its ligand SCF as well as hst1 and c-myc, are likely to play a role in the development of testicular cancer. In addition, identification and analysis of genes located on the frequently altered chromosome 12 represent an important focus of research. Genetic alterations may occur in a stepwise fashion, as described in other human tumors, leading to the development of the various histologic subtypes of testicular germ cell tumors. The characterization of these alterations are most likely to extend the traditional histopathologic tumor classifications.
Strohmeyer
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Department of Clinical Research and Development Oncology, Schering AG, Berlin, Germany.
D014408:Biomarkers, Tumor / Q000032:analysis / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics*; D002881:Chromosomes, Human, Pair 12; D054278:Embryonal Carcinoma Stem Cells; D066246:ErbB Receptors / Q000032:analysis / Q000235:genetics*; D051518:Fibroblast Growth Factor 3; D051519:Fibroblast Growth Factor 4; D005346:Fibroblast Growth Factors / Q000235:genetics; D005784:Gene Amplification; D015972:Gene Expression Regulation, Neoplastic; D005819:Genetic Markers; D018237:Germinoma / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008297:Male; D008967:Molecular Biology; D014411:Neoplastic Stem Cells / Q000473:pathology; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D011518:Proto-Oncogene Proteins / Q000235:genetics; D019009:Proto-Oncogene Proteins c-kit; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics; D011519:Proto-Oncogenes / Q000235:genetics*; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics; D018719:Erb-b2 Receptor Tyrosine Kinases; D016184:Receptors, Colony-Stimulating Factor / Q000235:genetics; D013736:Testicular Neoplasms / Q000175:diagnosis / Q000235:genetics*; D016211:Transforming Growth Factor alpha / Q000032:analysis / Q000235:genetics*
D014408:Biomarkers, Tumor; D066246:ErbB Receptors; D051518:Fibroblast Growth Factor 3; D051519:Fibroblast Growth Factor 4; D005346:Fibroblast Growth Factors; D005819:Genetic Markers; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins; D019009:Proto-Oncogene Proteins c-kit; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger; D020794:Receptor Protein-Tyrosine Kinases; D018719:Erb-b2 Receptor Tyrosine Kinases; D016184:Receptors, Colony-Stimulating Factor; D016211:Transforming Growth Factor alpha; C496444:FGF3 protein, human; C496445:FGF4 protein, human