The regularity of changes of the Chou-Fasman parameters within the genetic code.
It has been shown that Chou-Fasman conformational parameters of amino acids, which reflect their ability to adopt a definite conformation within the peptide chain, change very regularly within the genetic code, arranged in the manner discussed recently by Siemion and Stefanowicz (1992a) (BioSystems 27, 77-84). Two mutually perpendicular C2 axes of pseudosymmetry appear in the center of the diagrams (between ACY and ACR threonine codons) presenting the changes of P alpha and P beta parameters. The left and right parts of diagrams superimpose on each other quite well when the symmetry operation involving a proper axis is performed. This phenomenon is due, in our opinion, to the regular arrangement of equivalent codons in the 'one-step mutation' ring formed by 64 triplets of the genetic code.
Siemion
I Z
IZ
Institute of Chemistry, Wroctaw University, Poland.
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry / Q000235:genetics; D001483:Base Sequence; D003062:Codon / Q000235:genetics; D005815:Genetic Code; D008956:Models, Chemical; D008957:Models, Genetic; D008969:Molecular Sequence Data; D017354:Point Mutation; D011487:Protein Conformation; D012313:RNA / Q000235:genetics
D000596:Amino Acids; D003062:Codon; D012313:RNA