title: [Disorders of fetoplacental function in pregnant women with diabetes].
abstract: The paper presents the first results obtained as a part of a screening programme of detection of congenital developmental defects of the fetus. Pregnancies with diabetes are one of the risk groups in this respect. We have divided our patients (n = 58) into two groups. In the first there were 28 diabetics in the 15th-16th week of pregnancy. They were examined for alpha-1-fetoprotein (MS AFP) and trophoblast-specific beta-1-glycoprotein (MS SP1): in chosen cases chorionic gonadotropine (MS HCG) was assessed at the same time. The second group were 35 insulin-dependent pregnant diabetics followed-up in Regional Ambulance of Central Bohemia and hospitalized at the First Clinic of Obstetrics and Gynaecology of the First Medical Faculty, whose MS SP1 levels were being assessed (usually in one-week intervals) during the second and third trimester of pregnancy. 21 patients were simultaneously examined for glycated serum proteins. Our study confirmed MS AFP levels of diabetics in the 15th-16th week of pregnancy to be range of low limit of normal values (0.5-1.0 MOM). MS HCG levels in sera of diabetics ranged from 5,000 to 60,000 IU/ml in the 15th-16th week. Comparing glycated serum proteins of women with physiological pregnancies with those of healthy non-pregnant controls we had found no differences. In diabetics the values found in the second and third trimester of pregnancy were increased.
authors.affiliation: Ustav pro toxikologii a soudní chemii, lekarská fakulta Univerzity Karlovy, Praha.
authors.forename: L
authors.initials: L
authors.lastname: Mikulíková
authors.forename: J
authors.initials: J
authors.lastname: Struplová
authors.forename: L
authors.initials: L
authors.lastname: Fialová
authors.forename: I
authors.initials: I
authors.lastname: Malbohan
mesh_terms: D006063:Chorionic Gonadotropin / Q000097:blood; D000013:Congenital Abnormalities / Q000175:diagnosis; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis; D006801:Humans; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000097:blood*; D011268:Pregnancy-Specific beta 1-Glycoproteins / Q000032:analysis*; D011296:Prenatal Diagnosis; D000509:alpha-Fetoproteins / Q000032:analysis*
chemical_list: D006063:Chorionic Gonadotropin; D011268:Pregnancy-Specific beta 1-Glycoproteins; D000509:alpha-Fetoproteins