Expression of the receptor for macrophage colony stimulating factor by brain microglia and its upregulation in brains of patients with Alzheimer's disease and amyotrophic lateral sclerosis.
The receptor for macrophage colony stimulating factor (CSF-1) was localized immunohistochemically in postmortem human brain tissue. Microglia constitutively expressed the receptor for CSF-1 and its expression was upregulated in lesions of Alzheimer's disease and amyotrophic lateral sclerosis. The CSF-1 mediated pathway appears to be involved in the response and activation of microglia in the central nervous system lesions.
Akiyama
H
H
Tokyo Institute of Psychiatry, Japan.
Nishimura
T
T
Kondo
H
H
Ikeda
K
K
Hayashi
Y
Y
McGeer
P L
PL
D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000378:metabolism*; D000690:Amyotrophic Lateral Sclerosis / Q000378:metabolism*; D001921:Brain / Q000378:metabolism*; D002102:Cadaver; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D017628:Microglia / Q000378:metabolism*; D008875:Middle Aged; D016186:Receptor, Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D013194:Staining and Labeling; D015854:Up-Regulation
D016186:Receptor, Macrophage Colony-Stimulating Factor