Metastatic prostate cancer pulmonary nodules: beneficial effects of combination therapy and subsequent withdrawal of flutamide.
A case is presented of a middle-aged man suffering from stage D2 prostate cancer with pulmonary metastases who responded favorably, first, to endocrine combination therapy with the antiandrogen flutamide and an LHRH agonist for 5.5 years, and, second, to the subsequent withdrawal of Flutamide at the time of the progression of the disease. This case has several exceptional features: absence of bone metastases, pulmonary metastatic nodules characterized as focal neuroendocrine differentiation, and a positive response to antiandrogen withdrawal upon relapse of metastases after initial positive response. The concept of escape to androgen blockade and development of androgenic hypersensitivity is discussed.
Cusan
L
L
Endocrine Research Clinic, CHUL Research Center, Québec, Canada.
Gomez
J L
JL
Dupont
A
A
Diamond
P
P
Lemay
M
M
Moore
S
S
Labrie
F
F
D000135:Acid Phosphatase / Q000097:blood; D000230:Adenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001707:Biopsy, Needle; D001842:Bone and Bones / Q000000981:diagnostic imaging; D005485:Flutamide / Q000008:administration & dosage / Q000627:therapeutic use*; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000037:antagonists & inhibitors; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000556:secondary; D008297:Male; D008875:Middle Aged; D011467:Prostate / Q000201:enzymology / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000473:pathology*; D011877:Radionuclide Imaging; D013183:Sputum / Q000382:microbiology; D014057:Tomography, X-Ray Computed; D017329:Triptorelin Pamoate / Q000031:analogs & derivatives
D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D005485:Flutamide; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen; C066438:deslorelin