Cystic fibrosis heterozygote resistance to cholera toxin in the cystic fibrosis mouse model.
The effect of the number of cystic fibrosis (CF) alleles on cholera toxin (CT)-induced intestinal secretion was examined in the CF mouse model. CF mice that expressed no CF transmembrane conductance regulator (CFTR) protein did not secrete fluid in response to CT. Heterozygotes expressed 50 percent of the normal amount of CFTR protein in the intestinal epithelium and secreted 50 percent of the normal fluid and chloride ion in intestinal epithelium and secreted 50 percent of the normal fluid and chloride ion and fluid secretion suggests that CF heterozygotes might possess a selective advantage of resistance to cholera.
Gabriel
S E
SE
Department of Medicine, University of North Carolina, Chapel Hill 27599.
Brigman
K N
KN
Koller
B H
BH
Boucher
R C
RC
Stutts
M J
MJ
D000483:Alleles; D000818:Animals; D001826:Body Fluids / Q000378:metabolism*; D018118:Chloride Channels / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D002772:Cholera Toxin / Q000633:toxicity*; D003433:Crosses, Genetic; D000242:Cyclic AMP / Q000378:metabolism; D003550:Cystic Fibrosis / Q000235:genetics* / Q000503:physiopathology; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D005260:Female; D006579:Heterozygote; D007413:Intestinal Mucosa / Q000378:metabolism*; D007421:Intestine, Small / Q000378:metabolism; D008297:Male; D008565:Membrane Proteins / Q000235:genetics* / Q000378:metabolism; D051379:Mice
D018118:Chloride Channels; D002712:Chlorides; D008565:Membrane Proteins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D002772:Cholera Toxin; D000242:Cyclic AMP