Heparin enhances generation of natural killer activity in vitro.
The effect of heparin on generation and activity of NK cells in vitro were studied. Heparin decreased NK cytotoxicity when present in the assay. In contrast, the agent increased generation of NK cytotoxicity and showed synergistic action with recombinant IL2.
Wasik
M
M
Department of Laboratory Diagnostics, Medical Academy, Warsaw, Poland.
Górski
A
A
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic / Q000187:drug effects; D006493:Heparin / Q000494:pharmacology*; D006801:Humans; D016219:Immunotherapy, Adoptive; D007376:Interleukin-2 / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects* / Q000276:immunology*; D007938:Leukemia / Q000628:therapy; D014407:Tumor Cells, Cultured
D000276:Adjuvants, Immunologic; D007376:Interleukin-2; D006493:Heparin