Autocrine growth factors produced in the thyroid.
This catalogue of autocrine growth factors is limited to proteins--metabolites of iodine and prostaglandins are omitted and they are undoubtedly of autocrine importance in the thyroid, as elsewhere. However, this summary of polypeptide growth factors secreted by the thyroid illustrates the potential cells have to condition their environment to modify their responses to external stimuli. This enables cells in different tissues to respond to agonists in different ways. The effects of TSH on IGF, IGFBP and IGF receptor production and the effects of IGFBPs on IGF action are good examples of this amplified response. Many pieces of the jigsaw, however, remain to be found and put in place before a clear picture of the regulation and roles of these factors can be made.
Eggo
M C
MC
Department of Medicine, University of Birmingham, Queen Elizabeth Hospital, Edgbaston, UK.
Sheppard
M C
MC
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology; D002478:Cells, Cultured; D016232:Endothelins / Q000502:physiology; D006133:Growth Substances / Q000502:physiology*; D018970:Insulin-Like Growth Factor Binding Protein 1; D007378:Interleukins / Q000502:physiology; D051379:Mice; D051381:Rats; D017978:Receptors, Growth Factor / Q000502:physiology; D013552:Swine; D013961:Thyroid Gland / Q000502:physiology*; D013972:Thyrotropin / Q000502:physiology
D002352:Carrier Proteins; D016232:Endothelins; D006133:Growth Substances; D018970:Insulin-Like Growth Factor Binding Protein 1; D007378:Interleukins; D017978:Receptors, Growth Factor; D009320:Atrial Natriuretic Factor; D013972:Thyrotropin