title: [PSA volume quotient: an additional parameter in diagnosis of locally confined prostate cancer].
abstract: The sensitivity and specificity of prostate-specific antigen density (PSAD), a quotient of serum PSA and prostate volume, in the detection of localized prostate cancer was analysed in a prospective study. A total of 235 patients were examined, 145 without prostate cancer and 90 patients before radical prostatectomy for localized prostate cancer. PSAD was determined by dividing the serum level of PSA by the volume of the entire prostate (estimated by transrectal ultrasound) and multiplying by 100. Using a PSAD of 15, the specificity achieved in our collective was the same as with an absolute PSA value of 4 ng/ml (88.9-90%). On the other hand, with the PSAD of 15 we also found the same sensitivity as with an ab-solute PSA of 10 ng/ml (75.2-76.5%).
authors.affiliation: Urologische Universitätsklinik Ulm.
authors.forename: H W
authors.initials: HW
authors.lastname: Gottfried
authors.forename: K
authors.initials: K
authors.lastname: Kleinschmidt
authors.forename: P
authors.initials: P
authors.lastname: Flohr
authors.forename: K
authors.initials: K
authors.lastname: Miller
authors.forename: R
authors.initials: R
authors.lastname: Hautmann
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011467:Prostate / Q000473:pathology; D017430:Prostate-Specific Antigen / Q000097:blood*; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000473:pathology / Q000601:surgery; D012016:Reference Values
chemical_list: D017430:Prostate-Specific Antigen