Changes in the level of blood suppressor CD8+CD57+ lymphocytes, when HIV-1 p24 antigen reappears in the blood.
Using the marker Leu2 + Leu7 + to detect the CD8 suppressor cells (CD88+CD57+), we have observed that their blood level, which increases after primoinfection, during the latent period, increases still further just before and when the p24 antigen returns and is present in the blood. Its ratio over cytotoxic CD8+ cells remains high during the AIDS period, though the absolute number decreases.
Mathé
G
G
Institut de Cancérologie et d'Immunologie Hôpital Suisse de Paris, Issy-les-Moulineaux, France.
Morette
C
C
Hallard
M
M
Sala
M
M
Orbach-Arbouys
S
S
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015703:Antigens, CD / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D001772:Blood Cell Count; D018959:CD57 Antigens; D016827:CD8 Antigens / Q000276:immunology*; D016655:HIV Core Protein p24 / Q000276:immunology*; D006679:HIV Seropositivity / Q000097:blood; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D018959:CD57 Antigens; D016827:CD8 Antigens; D016655:HIV Core Protein p24