Human granulocyte colony-stimulating factor (G-CSF), the premier granulopoietin: biology, clinical utility, and receptor structure and function.
In summary, both G-CSF and GM-CSF have been identified, cloned, and produced for pharmacologic use in humans. While both G-CSF and GM-CSF have had significant impact in the treatment of neutropenic states, G-CSF appears to be more advantageous than GM-CSF in overall efficacy and paucity of side effects. Much has been discovered about the structure of the G-CSF receptor but further work is necessary to determine its mechanism of signal transduction. As our understanding of G-CSF signaling advances, the therapeutic impact of our knowledge about G-CSF biology will evolve from the current focus on enhancing its effects in hematologic and oncologic illnesses to decreasing its effects in inflammatory conditions where overexhuberant neutrophil infiltration and activation cause disease.
Tkatch
L S
LS
Department of Medicine, University of Pittsburgh School of Medicine, PA 15213.
Tweardy
D J
DJ
D000163:Acquired Immunodeficiency Syndrome / Q000628:therapy; D000595:Amino Acid Sequence; D000818:Animals; D016026:Bone Marrow Transplantation; D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology* / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D006098:Granulocytes / Q000378:metabolism / Q000502:physiology*; D006410:Hematopoiesis / Q000502:physiology*; D006801:Humans; D007938:Leukemia / Q000628:therapy; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000628:therapy*; D009503:Neutropenia / Q000628:therapy*; D011289:Preleukemia / Q000628:therapy; D016188:Receptors, Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism*; D015398:Signal Transduction; D033581:Stem Cell Transplantation
D016188:Receptors, Granulocyte Colony-Stimulating Factor; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor