Caloric restriction, aging, and antioxidant enzymes.
The basic mechanisms of aging and its retardation by caloric restriction (CR) remain unclear. One suggested means by which CR could retard aging is based on production of mitochondrial free radicals, and efficiency of their subsequent metabolism. Currently, there is little information concerning the influences of age and CR on the rates of in vivo mitochondrial free radical production. However, evidence for CR-induced modulation of free radical detoxification capacities is mounting. The direction of the influence of CR on free radical detoxification is tissue-specific. These effects are broad and appear to provide positive advantage.
Feuers
R J
RJ
Division of Genetic Toxicology, National Center for Toxicological Research, Jefferson, AR 72079.
Weindruch
R
R
Hart
R W
RW
D000375:Aging / Q000378:metabolism*; D000818:Animals; D000975:Antioxidants / Q000378:metabolism*; D002149:Energy Intake; D004798:Enzymes / Q000378:metabolism*; D005609:Free Radicals; D006801:Humans
D000975:Antioxidants; D004798:Enzymes; D005609:Free Radicals