title: Methyl tertiary butyl ether in human blood after exposure to oxygenated fuel in Fairbanks, Alaska.
abstract: Residents of Fairbanks, Alaska reported health complaints when 15%, by volume, methyl tertiary butyl ether (MTBE) was added to gasoline during an oxygenated fuel program. We conducted an exposure survey to investigate the effect of the program on human exposure to MTBE. We studied 18 workers in December 1992 during the program and 28 workers in February 1993 after the program was suspended. All workers were heavily exposed to motor vehicle exhaust or gasoline fumes. In December, the median post-shift blood concentration of MTBE in the workers was 1.8 micrograms/l (range, 0.2-37.0 micrograms/l), and in February the median post-shift blood concentration of MTBE in the 28 workers was 0.24 micrograms/l (range, 0.05-1.44 micrograms/l; p = .0001). Blood MTBE levels were measurably higher during the oxygenated fuel program in Fairbanks than after the program was suspended.
authors.affiliation: Centers for Disease Control and Prevention, National Center for Environmental Health, Atlanta, Georgia.
authors.forename: R L
authors.initials: RL
authors.lastname: Moolenaar
authors.forename: B J
authors.initials: BJ
authors.lastname: Hefflin
authors.forename: D L
authors.initials: DL
authors.lastname: Ashley
authors.forename: J P
authors.initials: JP
authors.lastname: Middaugh
authors.forename: R A
authors.initials: RA
authors.lastname: Etzel
mesh_terms: D000328:Adult; D000395:Air Pollutants, Occupational / Q000032:analysis; D000413:Alaska; D000440:Butanols / Q000097:blood; D004987:Ethers / Q000097:blood*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D005742:Gasoline / Q000032:analysis*; D006801:Humans; D008297:Male; D008738:Methyl Ethers; D016273:Occupational Exposure; D011795:Surveys and Questionnaires; D001335:Vehicle Emissions / Q000032:analysis; D020002:tert-Butyl Alcohol
chemical_list: D000395:Air Pollutants, Occupational; D000440:Butanols; D004987:Ethers; D005742:Gasoline; D008738:Methyl Ethers; D001335:Vehicle Emissions; C043243:methyl tert-butyl ether; D020002:tert-Butyl Alcohol