title: Age-dependent somatic excision of transposable element Tc1 in Caenorhabditis elegans.
abstract: The Tc1 element of the free-living nematode Caenorhabditis elegans is a well characterized transposon that is present in 30-500 copies per haploid genome, depending on the strain. Excision of Tc1 elements, which occurs readily in somatic tissues during larval development, has not previously been examined during aging of adult worms. We have identified a recently inserted Tc1 element in the KR1787 mutator strain of C. elegans and have found that Tc1 somatic excision at that site increases by more than 14-fold during the organism's lifespan.
authors.affiliation: University of Arkansas for Medical Sciences, Department of Medicine, Little Rock.
authors.forename: N K
authors.initials: NK
authors.lastname: Egilmez
authors.forename: R J
authors.initials: RJ
authors.lastname: Shmookler Reis
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D015139:Blotting, Southern; D017173:Caenorhabditis elegans / Q000235:genetics / Q000254:growth & development*; D003001:Cloning, Molecular; D004251:DNA Transposable Elements / Q000235:genetics*; D017384:Sequence Deletion
chemical_list: D004251:DNA Transposable Elements