[The content of dynorphin, Met-enk-Arg6-Phe7 and substance P (1-11) in the brain of mice with different levels of ethanol consumption].
The dynorphin A (1-17), Met-enkephalin-Arg6-Phe7 and substance P levels were determined by RIA following Sep-Pak separation in the striatum, hippocampus and spinal cord of three strains of mice (C57Bl10/D1, A/Sn, A. CA). The C57Bl10/D1 mice had high consumption of 10% ethanol at free choice schedule, whereas the A/Sn and A. CA mice had very low one. The Met-enkephalin-Arg6-Phe7 level was found to be decreased only in the spinal cord and striatum of C57Bl10/D1 mice. It is suggested that decreased synthesis or processing of the proenkephalin may at least partly determine the high level of ethanol consumption by this strain of mice.
Iukhananov
R Iu
RIu
Klodt
P M
PM
Shemanov
A Iu
AIu
Rat'kin
A E
AE
Nyberg
F
F
Maĭskiĭ
A I
AI
D000428:Alcohol Drinking / Q000378:metabolism*; D000704:Analysis of Variance; D000818:Animals; D001923:Brain Chemistry; D003342:Corpus Striatum / Q000737:chemistry; D004399:Dynorphins / Q000032:analysis*; D004744:Enkephalin, Methionine / Q000031:analogs & derivatives* / Q000032:analysis; D006624:Hippocampus / Q000737:chemistry; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D010446:Peptide Fragments / Q000032:analysis*; D011863:Radioimmunoassay / Q000706:statistics & numerical data; D013045:Species Specificity; D013116:Spinal Cord / Q000737:chemistry; D013373:Substance P / Q000032:analysis*
D010446:Peptide Fragments; D013373:Substance P; D004744:Enkephalin, Methionine; C027511:enkephalin-Met, Arg(6)-Phe(7)-; D004399:Dynorphins