title: Granulocyte colony-stimulating factor enhances the expression of CD62 on platelets in vivo.
abstract: The expression of CD41, CD42 and CD62 on platelets was determined in ten patients with and without G-CSF treatment. CD41 and CD42 is expressed in nearly 100% of the platelets without change after G-CSF treatment. The expression of CD62 on the platelets' surface is significantly enhanced by G-CSF indicating a depletion of the alpha-granules. No platelet aggregation was observed. The enhanced secretion of thrombocyte-specific proteins does not induce aggregation but may promote ADP-induced aggregation. Furthermore, the surface-bound and soluble CD62 binds specifically to macrophages and endothelial cells and is involved in the regulation of inflammatory processes. Thus indirect mechanisms may supplement direct effects of G-CSF after chemotherapy.
authors.affiliation: Abteilung Hämatologie und Onkologie, Medizinische Hochschule Hannover, Germany.
authors.forename: H J
authors.initials: HJ
authors.lastname: Avenarius
authors.forename: M
authors.initials: M
authors.lastname: Freund
authors.forename: H D
authors.initials: HD
authors.lastname: Kleine
authors.forename: P
authors.initials: P
authors.lastname: Heussner
authors.forename: H
authors.initials: H
authors.lastname: Poliwoda
mesh_terms: D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000097:blood*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology*; D006801:Humans; D008297:Male; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins / Q000097:blood*
chemical_list: D015703:Antigens, CD; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor