[Co-involvement of catecholaminergic and gabaergic transmission in the electro-cortical response to central galanin administration in the rabbit].
The involvement of catecholaminergic and gabaergic transmission in the electrocortical pattern induced by centrally administered galanin was investigated in the rabbit. The inhibition of catecholamine synthesis by both DDC and alphaMPT potentiated the EEG effect of the peptide. Baclofen and muscimol significantly enhanced the EEG response to GAL. However the interaction between the peptide and gabaergic transmission seemed mainly to involve the type A receptor system.
Maurelli
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M
Istituto Neurologico C. Mondino, Università di Pavia.
Marchioni
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Tartara
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D000818:Animals; D001418:Baclofen / Q000494:pharmacology; D002395:Catecholamines / Q000037:antagonists & inhibitors / Q000502:physiology*; D004050:Ditiocarb / Q000494:pharmacology; D004347:Drug Interactions; D004569:Electroencephalography / Q000187:drug effects*; D018756:GABA Antagonists; D019004:Galanin; D007276:Injections, Intraventricular; D008781:Methyltyrosines / Q000494:pharmacology; D009118:Muscimol / Q000494:pharmacology; D010455:Peptides / Q000008:administration & dosage / Q000494:pharmacology*; D011817:Rabbits; D009435:Synaptic Transmission / Q000187:drug effects*; D019805:alpha-Methyltyrosine; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D002395:Catecholamines; D018756:GABA Antagonists; D008781:Methyltyrosines; D010455:Peptides; D009118:Muscimol; D005680:gamma-Aminobutyric Acid; D019805:alpha-Methyltyrosine; D019004:Galanin; D004050:Ditiocarb; D001418:Baclofen