Mechanisms for the elimination of potentially lytic complement-fixing variable surface glycoprotein antibody-complexes in Trypanosoma brucei.
Live antibody-coated Trypanosoma brucei parasites remove variable surface glycoprotein (VSG)-antibody complexes from their surface upon warming to 37 degrees C and evade antibody-activated complement lysis by both protein synthesis-dependent and protein synthesis-independent mechanisms. The protein synthesis-dependent process follows antibody-mediated trypanosome agglutination, whereas the protein synthesis-independent mechanism can occur in the absence of trypanosome agglutination. The latter process leads to a more rapid elimination of complement-fixing VSG-antibody complexes.
Russo
D C
DC
L. F. Kimball Research Institute, New York Blood Center, NY 10021.
Williams
D J
DJ
Grab
D J
DJ
D000371:Agglutination; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D000913:Antibodies, Protozoan / Q000276:immunology*; D000918:Antibody Specificity; D000936:Antigen-Antibody Complex / Q000378:metabolism*; D003167:Complement Activation; D000939:Epitopes; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D015800:Protozoan Proteins / Q000096:biosynthesis; D014346:Trypanosoma brucei brucei / Q000166:cytology / Q000276:immunology*; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000936:Antigen-Antibody Complex; D000939:Epitopes; D015800:Protozoan Proteins; D014643:Variant Surface Glycoproteins, Trypanosoma