title: Antihypertensive activity of 6-O-galloyl-D-glucose, a phenolic glycoside from Sapium sebiferum.
abstract: The antihypertensive activity of a phenolic glycoside contained in the leaves of Sapium sebiferum was investigated. From intravenous screening using spontaneously hypertensive rats, 6-O-galloyl-D-glucose was identified as an active substance. The hypotensive action of this compound appears to be produced by an inhibition of noradrenaline release and/or a direct vasodilatation.
authors.affiliation: Department of Pharmacy, Taipei Medical College, Taiwan, Republic of China.
authors.forename: F L
authors.initials: FL
authors.lastname: Hsu
authors.forename: Y Y
authors.initials: YY
authors.lastname: Lee
authors.forename: J T
authors.initials: JT
authors.lastname: Cheng
mesh_terms: D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000494:pharmacology; D000315:Adrenalectomy; D000818:Animals; D000959:Antihypertensive Agents / Q000302:isolation & purification / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D047348:Hydrolyzable Tannins; D008729:Methoxamine / Q000494:pharmacology; D009638:Norepinephrine / Q000097:blood; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D011918:Rats, Inbred SHR; D013634:Tannins / Q000302:isolation & purification / Q000494:pharmacology*; D014664:Vasodilation / Q000187:drug effects
chemical_list: D000959:Antihypertensive Agents; D047348:Hydrolyzable Tannins; D013634:Tannins; C087111:6-O-galloylglucose; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D008729:Methoxamine; D009638:Norepinephrine