title: Modification of atrioventricular conduction using a combined laser-electrode catheter.
abstract: Ablation of the AV junction is an accepted technique for the management of selected supraventricular tachyarrhythmias. Radiofrequency ablation appears to be safe and effective for AV junction ablation in most patients, but the need for firm tissue contact may make it less effective for ventricular tachycardia and certain ectopic/atrial tachycardias. Laser energy can also be delivered through a catheter, and thus it may be an attractive alternative energy source for ablation. A new laser-electrode catheter was developed for modification of conduction through the AV node as a model for ablation of an arrhythmia substrate. A window for delivery of continuous-wave Nd:YAG laser energy was placed between the two electrodes of a bipolar electrode catheter. In vitro studies using a matrix of power versus time were performed to determine the energy that would create lesions of the appropriate size in vivo. Using this information, advanced AV block was successfully created in 16 of 17 dogs (94%) with the laser-electrode catheter. Advanced AV block was successfully created in all four dogs in the chronic study, and it persisted for 1-24 weeks of follow-up until sacrifice of the animals. Histologic examination demonstrated discrete thermal damage at the AV junction with no instances of septal perforation in the acute studies or progressive necrosis in chronically maintained dogs. Advanced AV block may be produced consistently and safely in dogs using a combined laser-electrode catheter.
authors.affiliation: Department of Medicine, University of Florida, Gainesville 32610.
authors.forename: A B
authors.initials: AB
authors.lastname: Curtis
authors.forename: M
authors.initials: M
authors.lastname: Mansour
authors.forename: S E
authors.initials: SE
authors.lastname: Friedl
authors.forename: T
authors.initials: T
authors.lastname: Tomaru
authors.forename: G R
authors.initials: GR
authors.lastname: Barbeau
authors.forename: S J
authors.initials: SJ
authors.lastname: Normann
authors.forename: G S
authors.initials: GS
authors.lastname: Abela
mesh_terms: D000538:Aluminum Silicates; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000601:surgery; D001283:Atrioventricular Node / Q000473:pathology / Q000601:surgery*; D002036:Bundle of His / Q000473:pathology / Q000503:physiopathology; D017115:Catheter Ablation / Q000295:instrumentation*; D004285:Dogs; D004562:Electrocardiography; D004566:Electrodes; D004867:Equipment Design; D006327:Heart Block / Q000601:surgery; D006339:Heart Rate / Q000502:physiology; D017075:Laser Coagulation / Q000295:instrumentation*; D009206:Myocardium / Q000473:pathology; D009354:Neodymium; D013997:Time Factors; D015019:Yttrium
chemical_list: D000538:Aluminum Silicates; D009354:Neodymium; D015019:Yttrium