CD46, a primate-specific receptor for measles virus.
Measles virus normally infects only primate cells. The receptor for measles virus has recently been shown to be the complement regulator CD46, also known as membrane cofactor protein. Transfection of rodent cells with human CD46 renders them susceptible to the virus, suggesting that transgenic animals may prove useful for testing antiviral agents and vaccines.
Dörig
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Biotechnology Research Institute, National Research Council of Canada, Montréal.
Marcil
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Richardson
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CD
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D004198:Disease Susceptibility; D000939:Epitopes / Q000276:immunology; D006801:Humans; D008457:Measles / Q000276:immunology / Q000821:virology*; D008459:Measles virus / Q000276:immunology*; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000276:immunology / Q000502:physiology*; D008969:Molecular Sequence Data; D011323:Primates / Q000276:immunology*
D015703:Antigens, CD; C497857:CD46 protein, human; D000939:Epitopes; D051916:Membrane Cofactor Protein; D008562:Membrane Glycoproteins