Galantide stimulates sexual behaviour in male rats.
While intracerebroventricular injection of galanin (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin. These data further suggest that galanin plays a physiological role in male sexual behavior.
Benelli
A
A
Department of Biomedical Sciences, University of Modena, Italy.
Arletti
R
R
Bertolini
A
A
Menozzi
B
B
Basaglia
R
R
Poggioli
R
R
D000818:Animals; D005260:Female; D019004:Galanin / Q000031:analogs & derivatives; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009479:Neuropeptides / Q000008:administration & dosage / Q000494:pharmacology; D010052:Ovariectomy; D010455:Peptides / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013373:Substance P / Q000031:analogs & derivatives*
D009479:Neuropeptides; D010455:Peptides; C074975:galantide; D013373:Substance P; D019004:Galanin