title: [Comparison of 5% human albumin and 6% 200/0.5 HES as exclusive colloid components in large surgical interventions].
abstract: OBJECTIVE
  It was the purpose of the following study to compare effects of 6% hydroxyethyl starch 200/0.5 (HES) and albumin 5% (HA5) on haemostasis, haemodynamics, oncotic function and plasmatic homoeostasis.
  
  
  METHODS
  In 2 randomised groups of 20 patients each undergoing large surgery (criteria of exclusion: anaemia, renal, liver, and coagulation disorders, ASA classification > III) we treated up to 1000 ml with colloid solution, from 1000 ml up to 5000 ml with packed red blood cells (PRBC) and colloid solution (1:1) and above 5000 ml with PRBC and fresh frozen plasma (1:1). Group HES received HES and group HA5 albumin as exclusive colloid component and both continuously lactated Ringers' at a rate of 500 ml/h. We measured the parameters before operation, after each 1000 ml colloid up to 3000 ml application and at the end of operation and we registered total blood output/intake.
  
  
  RESULTS
  We found comparable amounts of blood loss and blood intake (mean total amount of colloid solution: HES 2044 +/- 579 ml; HA5 2547 +/- 980 ml). We didn't find any differences in haemodynamics nor in haematocrit, platelets or global coagulation parameters which only showed dilutional influences. Differences existed in total serum protein (HES 32.8 +/- 6.5 gr/l; HA5 54 +/- 5.5 gr/l at OP's end); however COP was maintained in both groups during the whole study period at normal ranges. Plasmatic haemostasis showed to a large extent corresponding values. Remarkable was the development of a metabolic acidosis in the HA5 group.
  
  
  CONCLUSIONS
  Regarding total blood output/intake, haemodynamic functions, haematological parameters, coagulation, oncotic function, and plasmatic homoeostasis, HES is a safe colloid if contra-indications are taken into account, capable of replacing albumin 5% entirely as a colloid component of treatment of even large blood losses intraoperatively above the recommended dose of 20 ml/kg BW/d.
authors.affiliation: Klinik für Anästhesiologie, Kliniken der Universität Ulm.
authors.forename: N
authors.initials: N
authors.lastname: Vogt
authors.forename: U
authors.initials: U
authors.lastname: Bothner
authors.forename: M
authors.initials: M
authors.lastname: Georgieff
mesh_terms: D000328:Adult; D000368:Aged; D016063:Blood Loss, Surgical / Q000503:physiopathology*; D001802:Blood Substitutes / Q000008:administration & dosage*; D001810:Blood Volume / Q000502:physiology; D005260:Female; D005440:Fluid Therapy; D006400:Hematocrit; D006438:Hemodilution; D006439:Hemodynamics / Q000502:physiology*; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000008:administration & dosage*; D007431:Intraoperative Complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D012709:Serum Albumin / Q000008:administration & dosage*; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D001802:Blood Substitutes; D006895:Hydroxyethyl Starch Derivatives; D012709:Serum Albumin