Mutagenic activity of three synthetic isomers of the food carcinogen 2-amino-3-methylimidazo[4,5-f]quinoline (IQ) in the Ames test.
The mutagenic activities of three isomers of IQ, with the pyridine N-atom at different positions, were measured in the Ames test with Salmonella typhimurium TA98 and enzymatic activation (S9). All test compounds showed lower activities than IQ. Interestingly, the amount of protein in the S9 mix does not seem to influence the mutagenic activity of the '8-IQ' isomer.
Vikse
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Graduate Research Laboratory, Stabekk College, Bekkestua, Norway.
Klungsøyr
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Grivas
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D000818:Animals; D066298:In Vitro Techniques; D007536:Isomerism; D008099:Liver / Q000201:enzymology; D009152:Mutagenicity Tests / Q000379:methods; D009153:Mutagens / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D011804:Quinolines / Q000737:chemistry / Q000378:metabolism / Q000633:toxicity*; D051381:Rats; D012486:Salmonella typhimurium / Q000187:drug effects
D009153:Mutagens; D011804:Quinolines; C029216:2-amino-3-methylimidazo(4,5-f)quinoline