title: Antifungal effects of cyclosporine and FK 506 are mediated via immunophilin-dependent calcineurin inhibition.
authors.affiliation: Department of Genetics, Howard Hughes Medical Institute, Duke University Center, Durham, NC 27710.
authors.forename: J
authors.initials: J
authors.lastname: Heitman
authors.forename: M E
authors.initials: ME
authors.lastname: Cardenas
authors.forename: T
authors.initials: T
authors.lastname: Breuder
authors.forename: C
authors.initials: C
authors.lastname: Hemenway
authors.forename: R S
authors.initials: RS
authors.lastname: Muir
authors.forename: E
authors.initials: E
authors.lastname: Lim
authors.forename: L
authors.initials: L
authors.lastname: Goetz
authors.forename: D
authors.initials: D
authors.lastname: Zhu
authors.forename: M
authors.initials: M
authors.lastname: Lorenz
authors.forename: K
authors.initials: K
authors.lastname: Dolinski
mesh_terms: D000591:Amino Acid Isomerases / Q000096:biosynthesis / Q000235:genetics; D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology*; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D002352:Carrier Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D016572:Cyclosporine / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D006360:Heat-Shock Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism*; D008322:Mammals; D008954:Models, Biological; D016296:Mutagenesis; D019696:Peptidylprolyl Isomerase; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D012441:Saccharomyces cerevisiae / Q000187:drug effects* / Q000235:genetics / Q000378:metabolism; D016559:Tacrolimus / Q000494:pharmacology*; D022021:Tacrolimus Binding Proteins
chemical_list: D000935:Antifungal Agents; D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D006360:Heat-Shock Proteins; D016572:Cyclosporine; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases; D000591:Amino Acid Isomerases; D022021:Tacrolimus Binding Proteins; D019696:Peptidylprolyl Isomerase; D016559:Tacrolimus