In vivo localized proton NMR spectroscopy of thiamine-deficient rat brain.
Thiamine deficiency (TD) in rats produces lesions similar to those found in humans suffering from Wernicke's encephalopathy, an organic mental disorder associated with alcoholism. Male Sprague-Dawley rats (n = 29) were deprived of thiamine via a regimen of thiamine-deficient chow and daily intraperitoneal injections of the thiamine antagonist pyrithiamine hydrobromide. Spectra were obtained by using the STEAM sequence. No significant change occurred in the ratio of Cr/NAA, while the ratio of Cho/NAA declined significantly (60 +/- 11%) on Day 14. Eleven rats received intraperitoneal injections of thiamine hydrochloride at the end of 12 days, and dose-dependent recovery in Cho/NAA was observed.
Lee
H
H
Department of Radiology, Vanderbilt University Medical Center, Nashville, TN 37232-2675, USA.
Tarter
J
J
Holburn
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GE
Price
R R
RR
Weinstein
D D
DD
Martin
P R
PR
D000425:Alcohol Amnestic Disorder / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism* / Q000473:pathology; D003401:Creatine / Q000378:metabolism; D004151:Dipeptides / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D018698:Glutamic Acid / Q000378:metabolism; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D010725:Phosphocreatine / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013831:Thiamine / Q000627:therapeutic use; D013832:Thiamine Deficiency / Q000188:drug therapy / Q000378:metabolism*; D014899:Wernicke Encephalopathy / Q000378:metabolism
D004151:Dipeptides; D010725:Phosphocreatine; C027172:isospaglumic acid; D018698:Glutamic Acid; D003401:Creatine; D013831:Thiamine