title: Increased production of immune activation marker neopterin by colony-stimulating factors in gynecological cancer patients.
abstract: Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have recently been introduced in the treatment of chemotherapy-induced neutropenia. Effects of these CSFs on the cellular immune system were evaluated in 38 neutropenic gynecological cancer patients during chemotherapy. In addition to restoring the leukocyte count, GM-CSF--to a greater extent than G-CSF--also induced neopterin, a sensitive marker of macrophages activated by interferons. This effect was confirmed in vitro by investigating the effects of these CSFs on interferon-gamma-mediated pathways in THP-I human myelomonocytic cells. The results suggest activation of immune effector cells by GM-CSF.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital, Innsbruck, Austria.
authors.forename: C
authors.initials: C
authors.lastname: Marth
authors.forename: G
authors.initials: G
authors.lastname: Weiss
authors.forename: A
authors.initials: A
authors.lastname: Koza
authors.forename: G
authors.initials: G
authors.lastname: Reibnegger
authors.forename: G
authors.initials: G
authors.lastname: Daxenbichler
authors.forename: A G
authors.initials: AG
authors.lastname: Zeimet
authors.forename: D
authors.initials: D
authors.lastname: Fuchs
authors.forename: H
authors.initials: H
authors.lastname: Wachter
authors.forename: O
authors.initials: O
authors.lastname: Dapunt
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000652:urine; D001708:Biopterins / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000652:urine; D002460:Cell Line; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000276:immunology* / Q000378:metabolism; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D008875:Middle Aged; D019798:Neopterin
chemical_list: D014408:Biomarkers, Tumor; D016179:Granulocyte Colony-Stimulating Factor; D001708:Biopterins; D019798:Neopterin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor