Stimulation of gastric somatostatin mRNA abundance by substance P in capsaicin-treated rats.
The spinal afferent neurons serving the stomach influence a variety of different gastric functions that together can be considered protective; it is not known whether the stomach can adapt to the loss of these neurons. We now report that in conscious rats pretreated with capsaicin to lesion small-diameter afferents, but not in control rats, i.v. infusion of substance P for 6 h increased the abundance of mRNA encoding somatostatin in antrum; there was no change in a reference mRNA, glyceraldehyde phosphate dehydrogenase. Substance P had no effect on somatostatin mRNA in the gastric corpus in either control or capsaicin-treated rats. An increased sensitivity of antral somatostatin cells to substance P may be one of the adaptive changes that occurs in the stomach of capsaicin-treated rats.
Dimaline
R
R
Physiological Laboratory, University of Liverpool, UK.
Evans
D
D
Forster
E
E
Dockray
G J
GJ
D000818:Animals; D000831:Animals, Newborn; D015152:Blotting, Northern; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology; D002211:Capsaicin / Q000494:pharmacology*; D005753:Gastric Mucosa / Q000378:metabolism*; D015347:RNA Probes; D012333:RNA, Messenger / Q000096:biosynthesis*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000096:biosynthesis*; D013270:Stomach / Q000187:drug effects / Q000294:innervation; D013373:Substance P / Q000494:pharmacology*
D015347:RNA Probes; D012333:RNA, Messenger; D013373:Substance P; D013004:Somatostatin; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin