New finding of Schinzel-Giedion syndrome: a case with a malignant sacrococcygeal teratoma.
We report on a boy with Schinzel-Giedion syndrome (SGS) with a previously unreported manifestation, a malignant sacrococcygeal teratoma. This is the second case of SGS to have a malignancy, as one earlier case had a hepatoblastoma. We postulate that the occurrence of 2 uncommon embryonic tumors among these patients with a rare syndrome may mean that risk of malignancy may be a component of this syndrome.
Robin
N H
NH
Division of Human Genetics and Molecular Biology, Children's Hospital of Philadelphia, Pennsylvania 19104.
Grace
K
K
DeSouza
T G
TG
McDonald-McGinn
D
D
Zackai
E H
EH
D000015:Abnormalities, Multiple / Q000235:genetics; D001921:Brain / Q000473:pathology; D003050:Coccyx; D002658:Developmental Disabilities / Q000150:complications* / Q000235:genetics; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D012307:Risk Factors; D012447:Sacrum; D013577:Syndrome; D013724:Teratoma / Q000150:complications* / Q000175:diagnosis / Q000601:surgery