title: Chromosome studies in Alzheimer's disease patients: distribution of dicentric breakpoints in lymphocytes irradiated in vitro.
abstract: A previous study showed a significant increase in dicentric frequency in lymphocytes irradiated in vitro from non-familial Alzheimer's disease patients compared to normal age-matched controls. This study examined the distribution of the chromosome breakpoints involved in the dicentric formation and found a non-specific increase in all chromosomes.
authors.affiliation: Genetics Unit, Geoffrey Schofield Laboratories, British Nuclear Fuels plc, Westlakes Science and Technology Park, Moor Rowe, Cumbria, UK.
authors.forename: C A
authors.initials: CA
authors.lastname: Shippey
authors.forename: S E
authors.initials: SE
authors.lastname: Tobi
authors.forename: R F
authors.initials: RF
authors.lastname: Itzhaki
authors.forename: E J
authors.initials: EJ
authors.lastname: Tawn
mesh_terms: D000544:Alzheimer Disease / Q000235:genetics*; D002869:Chromosome Aberrations; D002878:Chromosomes, Human, Pair 1; D002889:Chromosomes, Human, Pair 2; D002893:Chromosomes, Human, Pair 3; D004260:DNA Repair; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000528:radiation effects; D008297:Male