title: Immediate adverse reaction to aminophylline.
abstract: We present a patient who experienced an immediate adverse reaction following intravenous administration of aminophylline. Skin prick, intradermal, and patch tests, RAST and indirect ELISA assays with aminophylline, theophylline and ethylenediamine were negative. A positive histamine release test was found only with ethylenediamine. Single-blind placebo-controlled challenges were positive with aminophylline and negative with theophylline. Our results suggest the reaction was a type I hypersensitivity reaction to ethylenediamine, but a nonimmune mechanism could not be excluded.
authors.affiliation: Department of Allergy, General Hospital, Albacete, Spain.
authors.forename: B
authors.initials: B
authors.lastname: de la Hoz
authors.forename: C
authors.initials: C
authors.lastname: Pérez
authors.forename: M A
authors.initials: MA
authors.lastname: Tejedor
authors.forename: M
authors.initials: M
authors.lastname: Lázaro
authors.forename: F
authors.initials: F
authors.lastname: Salazar
authors.forename: M
authors.initials: M
authors.lastname: Cuevas
mesh_terms: D000284:Administration, Oral; D000368:Aged; D000628:Aminophylline / Q000008:administration & dosage / Q000009:adverse effects*; D017449:Dermatitis, Allergic Contact / Q000209:etiology; D004342:Drug Hypersensitivity / Q000209:etiology*; D005029:Ethylenediamines / Q000276:immunology; D005260:Female; D006636:Histamine Release; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology; D007114:Immunization; D009532:Nickel / Q000009:adverse effects; D012882:Skin Tests
chemical_list: D005029:Ethylenediamines; D000628:Aminophylline; C031234:ethylenediamine; D009532:Nickel