Inter-alpha-trypsin inhibitor polymorphism. An improved phenotyping procedure and two new alleles.
Serum samples treated with chondroitinase ABC and sialidase were investigated for the detection of inter-alpha-trypsin inhibitor (ITI) polymorphism. The improved phenotyping procedure has proved to be the most practical method for ITI phenotyping. The ITI allele frequencies were examined in 2 population samples from Japanese (n = 365) and Thais (n = 150). Three common alleles, ITI*1, ITI*2, and ITI*3 were identified in both populations, but the Thai population showed a higher frequency of ITI*1 and a lower frequency of ITI*3. Two new alleles were found, which were tentatively denoted ITI*Y and ITI*T. The ITI*T allele frequency in Thais was 0.047.
Harada
A
A
Department of Forensic Medicine, Yamagata University School of Medicine, Japan.
Umetsu
K
K
Suzuki
T
T
D000483:Alleles; D000510:Alpha-Globulins / Q000235:genetics*; D005787:Gene Frequency / Q000235:genetics; D005828:Genetics, Population; D006801:Humans; D007564:Japan; D010641:Phenotype; D011110:Polymorphism, Genetic / Q000235:genetics*; D013785:Thailand; D014361:Trypsin Inhibitors / Q000235:genetics*
D000510:Alpha-Globulins; D014361:Trypsin Inhibitors; C011877:inter-alpha-inhibitor