Cytotoxic diterpenoids from Isodon megathyrsus.
A new diterpenoid, megathyrin A, together with three known compounds, rabdocoetsins B, C, and D, were isolated from the leaves of Isodon megathyrsus, and their structures and nmr spectral data were assigned by a combination of one- and two-dimensional nmr techniques. These compounds displayed significant cytotoxic activity.
Sun
H D
HD
Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Kunming, Yunnan, People's Republic of China.
Lin
Z W
ZW
Niu
F D
FD
Lin
L Z
LZ
Chai
H
H
Pezzuto
J M
JM
Cordell
G A
GA
D000962:Antimalarials / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification / Q000494:pharmacology*; D002470:Cell Survival / Q000187:drug effects; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D004365:Drugs, Chinese Herbal / Q000737:chemistry / Q000494:pharmacology*; D054303:HIV Reverse Transcriptase; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D018894:Reverse Transcriptase Inhibitors
D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase