title: Reversibility of brain-stem evoked potential abnormalities in abstinent chronic alcoholics: one year follow-up.
abstract: Brain-stem auditory evoked potentials (BAEPs) were studied in 34 chronic alcoholics who had been abstinent for 1 year, and in age- and sex-matched control subjects. The patients were examined 3 times, at 1 month, 5 months and 1 year after the start of the abstinence treatment. At 1 month of abstinence the alcoholics showed differences with respect to controls in the peak V latency (P < 0.01), and in the III-V (P < 0.01) and I-V (P < 0.01) intervals. After 1 year of abstinence a significant improvement in the V (P < 0.01), III-V (P < 0.01) and I-V (P < 0.01) parameters was recorded. The most notable development was in the 5-12 month period, with shortening in V latency (P < 0.01) and in the I-V interval (P < 0.01); in the first 5 months there was only shortening in the III-V interval (P < 0.01). This improvement was also indicated by a decrease in the number of patients with BAEP parameter abnormalities. The recovery of the functions impaired by chronic alcohol consumption after 1 year of abstinence was incomplete, although the tendency was towards normalization.
authors.affiliation: Departamento de Psicoloxía Clínica e Psicobioloxía, Universidade de Santiago de Compostela, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Cadaveira
authors.forename: M
authors.initials: M
authors.lastname: Corominas
authors.forename: S
authors.initials: S
authors.lastname: Rodríguez Holguín
authors.forename: M
authors.initials: M
authors.lastname: Sánchez-Turet
authors.forename: C
authors.initials: C
authors.lastname: Grau
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000437:Alcoholism / Q000503:physiopathology*; D000704:Analysis of Variance; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011930:Reaction Time / Q000502:physiology