title: Sequence and localization of a novel FK506-binding protein to mouse chromosome 11.
abstract: We have isolated a unique gene from a mouse JB6 epidermal cell cDNA expression library, termed FKBPRP, that codes for a protein having domains that share between 37 and 44% amino acid sequence identity and 60% similarity with members of the family of FK506-binding proteins. The FKBPRP protein has three repeats contained within its sequence that share between 48 and 58% identity to each other. We have localized the FKBPRP gene to mouse Chromosome 11, and crosses of different murine strains provided the gene order centromere--FKBPRP-Int-4-Pkca-Es-3.
authors.affiliation: Biological Carcinogenesis and Development Program, NCI-Frederick Cancer Research and Development Center, Frederick, Maryland.
authors.forename: S L
authors.initials: SL
authors.lastname: Simek
authors.forename: C A
authors.initials: CA
authors.lastname: Kozak
authors.forename: D
authors.initials: D
authors.lastname: Winterstein
authors.forename: G
authors.initials: G
authors.lastname: Hegamyer
authors.forename: N H
authors.initials: NH
authors.lastname: Colburn
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D002874:Chromosome Mapping; D006360:Heat-Shock Proteins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D017386:Sequence Homology, Amino Acid; D016559:Tacrolimus / Q000378:metabolism*; D022021:Tacrolimus Binding Proteins
chemical_list: D002352:Carrier Proteins; D006360:Heat-Shock Proteins; D022021:Tacrolimus Binding Proteins; D016559:Tacrolimus