Effect of purinergic receptor antagonists suramin and theobromine on tumor-induced angiogenesis in BALB/c mice.
The purinergic receptor antagonists suramin (SRN) and theobromine (TBR) were examined for their anti-angiogenic activity in BALB/c mice. SRN or TBR were subcutaneously administered to BALB/c mice in doses of 1-125 mg/kg body weight on days 0, 1 and 2 after intradermal inoculation of E14/W lung carcinoma cells. It was shown that SRN and TBR inhibited tumor-related angiogenesis. Accordingly, it may be suggested that purinoceptor antagonists may inhibit neovascularization in tumor growth and metastasis.
Gil
M
M
National Research Institute of Tuberculosis and Lung Diseases, Warsaw.
Skopińska-Rózewska
E
E
Radomska
D
D
Demkow
U
U
Skurzak
H
H
Rochowska
M
M
Beuth
J
J
Roszkowski
K
K
D000818:Animals; D002277:Carcinoma / Q000098:blood supply; D007279:Injections, Subcutaneous; D008175:Lung Neoplasms / Q000098:blood supply; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009374:Neoplasms, Experimental / Q000098:blood supply* / Q000188:drug therapy; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D058914:Purinergic Antagonists; D013498:Suramin / Q000494:pharmacology*; D013805:Theobromine / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D058914:Purinergic Antagonists; D013498:Suramin; D013805:Theobromine