Neurofibromatosis 1 mRNA expression in blood vessels.
Vascular hypertrophic lesions occur in neurofibromatosis type 1 (NF1). The role of the gene which causes NF1 in the growth and development of blood vessels is not known. mRNA expression of the NF1 gene was studied in blood vessels in the transition between intact and culture and in quiescent and proliferative conditions. The expression and alternative splicing pattern of the catalytic domain of NF1 consistently changed in proliferating cells, supporting a role for this gene in the regulation of growth of vascular smooth muscle and the vascular pathology in NF1.
Ahlgren-Beckendorf
J A
JA
Department of Neurology, University of Texas Medical Branch, Galveston 77555.
Maggio
W W
WW
Chen
F
F
Kent
T A
TA
D000818:Animals; D001011:Aorta / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D002455:Cell Division; D002478:Cells, Cultured; D017931:DNA Primers; D018076:DNA, Complementary / Q000096:biosynthesis / Q000378:metabolism; D015870:Gene Expression / Q000187:drug effects; D016514:Genes, Neurofibromatosis 1; D006801:Humans; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D009456:Neurofibromatosis 1 / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000379:methods; D012333:RNA, Messenger / Q000096:biosynthesis* / Q000378:metabolism; D012194:RNA-Directed DNA Polymerase; D051381:Rats; D011921:Rats, Inbred WKY; D012701:Serotonin / Q000494:pharmacology
D017931:DNA Primers; D018076:DNA, Complementary; D012333:RNA, Messenger; D012701:Serotonin; D012194:RNA-Directed DNA Polymerase