title: NG-nitro-L-arginine methyl ester does not affect balloon catheter-induced intimal hyperplasia in rats.
abstract: The L-arginine derived NO-cGMP pathway's role in the response of the arterial wall to balloon catheter injury was examined. Rats were given the nitric oxide synthase inhibitor NG-nitro-L-arginine methyl ester (10 mg/kg po twice daily) or vehicle for 6 days before and 2 weeks after balloon catheter injury. NG-nitro-L-arginine methyl ester treatment increased blood pressure and inhibited acetylcholine responses in aortic rings but did not alter the lesions produced by balloon injury. Our results suggest that the L-arginine derived NO-cGMP pathway does not play a significant role in the response of the artery wall to balloon injury in the rat.
authors.affiliation: Schering-Plough Research Institute, Kenilworth, New Jersey.
authors.forename: R W
authors.initials: RW
authors.lastname: Watkins
authors.forename: K
authors.initials: K
authors.lastname: Pula
authors.forename: J
authors.initials: J
authors.lastname: Cook
authors.forename: L
authors.initials: L
authors.lastname: Hoos
authors.forename: R
authors.initials: R
authors.lastname: McLeod
authors.forename: N A
authors.initials: NA
authors.lastname: Prioli
authors.forename: H R
authors.initials: HR
authors.lastname: Davis
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D002339:Carotid Arteries / Q000187:drug effects / Q000473:pathology*; D020212:Carotid Artery Injuries; D002404:Catheterization; D006152:Cyclic GMP / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D006965:Hyperplasia / Q000209:etiology*; D066298:In Vitro Techniques; D008297:Male; D019331:NG-Nitroarginine Methyl Ester; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase; D051381:Rats; D017207:Rats, Sprague-Dawley; D017539:Tunica Intima / Q000187:drug effects / Q000293:injuries / Q000473:pathology*
chemical_list: D009569:Nitric Oxide; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D006152:Cyclic GMP; D000109:Acetylcholine; D019331:NG-Nitroarginine Methyl Ester