title: Structure and chromosomal localization of the gene encoding the human myelin protein zero (MPZ).
abstract: We describe the cloning, characterization, and chromosomal mapping of the human myelin protein zero (MPZ) gene. The gene is about 7 kb long and consists of six exons corresponding to the functional domains. All exon-intron junction sequences conform to the GT/AG rule. The 5'-flanking region of the gene has a TA-rich element (TATA-like box), two CAAT boxes, and a single defined transcription initiation site detected by the primer extension method. The gene for human MPZ was assigned to chromosome 1q22-q23 by spot blot hybridization of flow-sorted human chromosomes and fluorescence in situ hybridization. The localization of the MPZ gene coincides with the locus for Charcot-Marie-Tooth disease type 1B, determined by linkage analysis.
authors.affiliation: Department of Pediatrics, Akita University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hayasaka
authors.forename: M
authors.initials: M
authors.lastname: Himoro
authors.forename: Y
authors.initials: Y
authors.lastname: Wang
authors.forename: M
authors.initials: M
authors.lastname: Takata
authors.forename: S
authors.initials: S
authors.lastname: Minoshima
authors.forename: N
authors.initials: N
authors.lastname: Shimizu
authors.forename: M
authors.initials: M
authors.lastname: Miura
authors.forename: K
authors.initials: K
authors.lastname: Uyemura
authors.forename: G
authors.initials: G
authors.lastname: Takada
mesh_terms: D001483:Base Sequence; D002607:Charcot-Marie-Tooth Disease / Q000235:genetics; D002878:Chromosomes, Human, Pair 1; D018076:DNA, Complementary / Q000235:genetics; D005091:Exons; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007438:Introns; D008969:Molecular Sequence Data; D018993:Myelin P0 Protein; D009185:Myelin Proteins / Q000235:genetics*; D015183:Restriction Mapping
chemical_list: D018076:DNA, Complementary; D018993:Myelin P0 Protein; D009185:Myelin Proteins