Cytogenetic findings in malignant triton tumor.
Malignant triton tumor is a rare histologic variant of malignant schwannoma that shows both neural and skeletal muscle differentiation. In this study, cytogenetic analysis of a recurrent malignant triton tumor of the forearm from a 26-year-old female and a primary paraspinal malignant triton tumor from a 27-year-old female revealed complex karyotypes displaying multiple numerical and structural abnormalities. Abnormalities shared by both tumors included three copies of chromosome 22 and structural rearrangements of chromosomes 2, 7, and 21 at identical or closely located breakpoints.
Travis
J A
JA
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5440.
Sandberg
A A
AA
Neff
J R
JR
Bridge
J A
JA
D000328:Adult; D002869:Chromosome Aberrations / Q000235:genetics*; D025063:Chromosome Disorders; D005260:Female; D006801:Humans; D007621:Karyotyping; D009442:Neurilemmoma / Q000235:genetics*; D013125:Spinal Neoplasms / Q000235:genetics*; D013933:Thumb