title: Protein metabolism in brain and muscle tissues of Mus booduga following repeated oral benzenehexachloride feeding.
abstract: Protein metabolism was studied in the brain and muscle tissues of mice, Mus booduga after administering orally 50 mg/kg body weight of benzenehexachloride (BHC) daily for 1, 5 and 15 days. Both tissues exhibited considerable decline in all the protein fractions such as total, soluble and structural proteins. This corroborates with the increased levels of free amino acids (FAA) and protease. To fortify these alterations, elevation in the activities of aspartate aminotransferase (AAT), alanine aminotransferase (AlAT) and glutamate dehydrogenase (GDH) were noticed. The two nitrogenous end products namely, ammonia and urea levels were also increased. These results clearly demonstrate the impairment of protein metabolism due to sublethal BHC toxicity.
authors.affiliation: Department of Zoology, Sri Krishnadevaraya University, Anantapur, India.
authors.forename: G H
authors.initials: GH
authors.lastname: Philip
authors.forename: P M
authors.initials: PM
authors.lastname: Reddy
authors.forename: R
authors.initials: R
authors.lastname: Ramamurthi
mesh_terms: D000284:Administration, Oral; D000410:Alanine Transaminase / Q000378:metabolism; D000641:Ammonia / Q000378:metabolism; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001921:Brain / Q000187:drug effects / Q000378:metabolism*; D005969:Glutamate Dehydrogenase / Q000378:metabolism; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000633:toxicity*; D051379:Mice; D018482:Muscle, Skeletal / Q000187:drug effects / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D014508:Urea / Q000378:metabolism
chemical_list: D011506:Proteins; D001556:Hexachlorocyclohexane; D000641:Ammonia; D014508:Urea; D005969:Glutamate Dehydrogenase; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase