The effect of TPP, theophylline and theobromine on the angiogenic activity of mononuclear leucocytes obtained from diabetic patients with proliferative retinopathy.
Tołpa Peat Preparation (TPP) administered in various doses does not influence the ability of mononuclear cells (MNC) obtained from diabetic patients with proliferative retinopathy to induce neovascularization response in H-LIA test. Methylxanthines (theophylline, theobromine) significantly decrease the angiogenic activity of these cells. The therapeutic value of these drugs in proliferative retinopathy should be evaluated.
Skopiński
P
P
Laboratory of Electron Microscopy, Institute of Biostructure, School of Medicine, Warsaw, Poland.
Zukowska
M
M
Małkowska-Zwierz
W
W
Radomska
D
D
Retelska
D
D
Kecik
D
D
Domosławski
M
M
Sobczyńska
A
A
Pawińska
M
M
Skopińska-Rózewska
E
E
D000293:Adolescent; D000328:Adult; D000596:Amino Acids / Q000494:pharmacology*; D000818:Animals; D002241:Carbohydrates / Q000494:pharmacology*; D002648:Child; D003930:Diabetic Retinopathy / Q000473:pathology*; D004338:Drug Combinations; D006801:Humans; D006812:Humic Substances / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic / Q000209:etiology*; D012987:Soil; D013805:Theobromine / Q000494:pharmacology*; D013806:Theophylline / Q000494:pharmacology*; D014574:Uronic Acids / Q000494:pharmacology*
D000596:Amino Acids; D002241:Carbohydrates; D004338:Drug Combinations; D006812:Humic Substances; D012987:Soil; C084029:Tolpa; D014574:Uronic Acids; D013806:Theophylline; D013805:Theobromine