title: Malignant transformation of benign gliomas during interstitial irradiation.
abstract: Interstitial curietherapy with 125-Iodine is an effective therapeutic option in the treatment of low grade gliomas. Four cases with astrocytoma grade II are presented, where tumour growth characteristics have changed to anaplasia during interstitial irradiation after a primary period of tumour regression. Anaplastic transformation could be due to a radiation effect or an insufficient therapeutic influence of interstitial irradiation on natural tumour progression of glioma growth due to genetic events.
authors.affiliation: Department of Neurosurgery, Philipps University Marburg, Federal Republic of Germany.
authors.forename: D
authors.initials: D
authors.lastname: Hellwig
authors.forename: H D
authors.initials: HD
authors.lastname: Mennel
authors.forename: B L
authors.initials: BL
authors.lastname: Bauer
authors.forename: E
authors.initials: E
authors.lastname: List-Hellwig
authors.forename: E A
authors.initials: EA
authors.lastname: Koop
authors.forename: H O
authors.initials: HO
authors.lastname: Neidel
mesh_terms: D000328:Adult; D001254:Astrocytoma / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D001918:Brachytherapy; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery; D002455:Cell Division / Q000528:radiation effects*; D002471:Cell Transformation, Neoplastic / Q000473:pathology / Q000528:radiation effects*; D003131:Combined Modality Therapy; D017809:Fatal Outcome; D005260:Female; D005909:Glioblastoma / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D006801:Humans; D007457:Iodine Radioisotopes / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D009381:Neoplasms, Radiation-Induced / Q000473:pathology* / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D014057:Tomography, X-Ray Computed
chemical_list: D007457:Iodine Radioisotopes