Cytokine production in patients with mite-sensitive bronchial asthma.
We examined the eosinophil viability-enhancing activity (EVEA) of peripheral blood mononuclear cells (PBMNCs) obtained from mite-sensitive bronchial asthma (BA) and normal control subjects. Mite concentrations of 1 and 10 micrograms/ml significantly increased EVEA in BA patients as compared with normal controls (p < 0.05 and p < 0.05, respectively). The level of IFN-gamma in PBMNC culture supernatants was higher in BA patients than in normal controls. Dexamethasone, cyclosporin A and FK506 significantly inhibited EVEA in BA patients (p < 0.05 to p < 0.001).
Okubo
Y
Y
First Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto, Japan.
Hossain
M
M
Sekiguchi
M
M
D000485:Allergens / Q000009:adverse effects*; D000818:Animals; D000906:Antibodies / Q000494:pharmacology; D001249:Asthma / Q000276:immunology* / Q000378:metabolism; D002470:Cell Survival / Q000187:drug effects / Q000276:immunology; D016572:Cyclosporine / Q000494:pharmacology; D016207:Cytokines / Q000096:biosynthesis*; D003907:Dexamethasone / Q000494:pharmacology; D004804:Eosinophils / Q000166:cytology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis / Q000276:immunology; D006801:Humans; D007371:Interferon-gamma / Q000096:biosynthesis / Q000276:immunology; D007377:Interleukin-3 / Q000096:biosynthesis / Q000276:immunology; D015848:Interleukin-5 / Q000096:biosynthesis / Q000276:immunology; D008925:Mites / Q000276:immunology*; D016559:Tacrolimus / Q000494:pharmacology
D000485:Allergens; D000906:Antibodies; D016207:Cytokines; D007377:Interleukin-3; D015848:Interleukin-5; D003907:Dexamethasone; D007371:Interferon-gamma; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D016572:Cyclosporine; D016559:Tacrolimus