Serum insulin-like growth factor binding protein-1 in pregnant women: decreased concentrations following an oral glucose load.
Serum concentrations of insulin-like growth factor binding protein-1 (IGFBP-1) were measured in men and in non-pregnant and pregnant women. Peak serum IGFBP-1 levels occurred mid-gestation followed by a slight decline towards term. Women with gestational diabetes had higher serum IGFBP-1 concentrations than apparently healthy women at comparable gestation. Following administration of an oral glucose load, serum IGFBP-1 concentrations were decreased within 2 h in men and in pregnant women while IGF-I levels remained constant. These results suggested that IGFBP-1 regulates IGF-I activity in pregnancy in a similar manner to that in the non-pregnant state.
O'Leary
P C
PC
Department of Pathology, King Edward Memorial Hospital for Women, Subiaco, Australia.
Longley
M
M
D000284:Administration, Oral; D002352:Carrier Proteins / Q000097:blood*; D016640:Diabetes, Gestational / Q000097:blood*; D005260:Female; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D018969:Insulin-Like Growth Factor Binding Proteins; D008297:Male; D011247:Pregnancy / Q000097:blood*; D011863:Radioimmunoassay; D013002:Somatomedins
D002352:Carrier Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D013002:Somatomedins; D005947:Glucose