A double-blind comparison of nimesulide and ketoprofen in dental surgery.
The efficacy and tolerability of nimesulide were compared with those of ketoprofen when administered rectally in a double-blind investigation of 46 patients scheduled for dental surgery. Nimesulide was more effective and more rapid than ketoprofen in ameliorating the painful inflammatory symptoms (pain at rest and upon mastication) and signs (swelling and hyperaemia) associated with the operation. These effects were accompanied by improved quality of sleep and recovery of masticatory and swallowing function, which was superior for nimesulide-treated patients.
Pierleoni
P
P
Istituto di OdontoGnatoStomatologia, Università di Firenze, Italy.
Tonelli
P
P
Scaricabarozzi
I
I
D000328:Adult; D000368:Aged; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007249:Inflammation / Q000188:drug therapy*; D007660:Ketoprofen / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010149:Postoperative Pain / Q000188:drug therapy*; D013449:Sulfonamides / Q000627:therapeutic use*; D014081:Tooth Extraction; D014095:Tooth, Impacted / Q000601:surgery
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D007660:Ketoprofen; C012655:nimesulide