Differential expression of interleukin-2 receptors (alpha and beta chain) in mature lymphoid neoplasms.
We investigated the expression of interleukin-2 receptors (IL-2R) in 60 adult patients with mature lymphoid neoplasms by flow cytometric analysis, using two monoclonal antibodies, anti-Tac for IL-2R alpha-chain (IL-2R alpha) and Mik-beta 1 for IL-2R beta-chain (IL-2R beta). Among B-cell malignancies, IL-2R alpha was found in 13/25 (52%) cases of chronic lymphocytic leukemia (CLL) and its variants, 3/14 (21%) of a heterogeneous group of non-Hodgkin's lymphoma (NHL) and none of the plasma cell diseases. IL-2R beta was not observed in any of B-cell neoplasms. IL-2R alpha was more frequently expressed in CD11b(+) B-cell neoplasms than in CD11b(-) (P < 0.05). In T-cell disorders, all three cases of adult T-cell leukemia/lymphoma expressed IL-2R alpha but not IL-2R beta. IL-2R beta was detected in 3/8 cases of CLL and 2/3 of NHL and none of these cases expressed IL-2R alpha. CD8(+) malignant T-cells commonly displayed IL-2R beta. These data indicate that the IL-2R alpha and IL-2R beta in mature lymphoid neoplasms was expressed independently each other and was associated with the particular phenotypical characteristics of neoplastic cells, respectively.
Nakase
K
K
Department of Internal Medicine, Yamada Red Cross Hospital, Misono, Japan.
Kita
K
K
Nasu
K
K
Ueda
T
T
Tanaka
I
I
Shirakawa
S
S
Tsudo
M
M
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D018956:CD5 Antigens; D016827:CD8 Antigens / Q000032:analysis; D005434:Flow Cytometry; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000276:immunology / Q000473:pathology; D007952:Leukemia, Plasma Cell / Q000276:immunology / Q000473:pathology; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000276:immunology / Q000473:pathology; D008223:Lymphoma / Q000737:chemistry / Q000276:immunology / Q000648:ultrastructure*; D015375:Receptors, Interleukin-2 / Q000737:chemistry / Q000276:immunology / Q000502:physiology*
D015703:Antigens, CD; D018956:CD5 Antigens; D016827:CD8 Antigens; D015375:Receptors, Interleukin-2