Changes in liver drug glucuronidation during cholestasis are non predictable.
Liver microsomal glucuronidation of acetaminophen, chloramphenicol, salicylic acid, lorazepam, p-nitrophenol and morphine were measured in 8 days bile duct ligated rats. Compared to normals, cholestatic rats showed a decrease of 31% for p-nitrophenol glucuronidation; salicylic acid glucuronidation increased 281%; acetaminophen glucuronidation increased 38% while morphine, chloramphenicol and lorazepam values were similar to controls. We concluded that cholestasis produces non predictable changes on liver drug glucuronidation pathways.
Ouvina
G B
GB
Catedra de Fisiopatologia, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires.
Lemberg
A
A
Bengochea
L A
LA
D000082:Acetaminophen / Q000378:metabolism; D000818:Animals; D002701:Chloramphenicol / Q000378:metabolism; D002779:Cholestasis / Q000378:metabolism*; D005965:Glucuronates / Q000378:metabolism*; D014453:Glucuronosyltransferase / Q000378:metabolism; D008140:Lorazepam / Q000378:metabolism; D008297:Male; D008862:Microsomes, Liver / Q000378:metabolism*; D009020:Morphine / Q000378:metabolism; D009243:NAD / Q000378:metabolism; D009596:Nitrophenols / Q000378:metabolism; D004364:Pharmaceutical Preparations / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012459:Salicylates / Q000378:metabolism; D020156:Salicylic Acid
D005965:Glucuronates; D009596:Nitrophenols; D004364:Pharmaceutical Preparations; D012459:Salicylates; D009243:NAD; D000082:Acetaminophen; D002701:Chloramphenicol; D009020:Morphine; D014453:Glucuronosyltransferase; D008140:Lorazepam; D020156:Salicylic Acid