title: Primary rhabdoid tumour of the skin in a 14-month-old child.
abstract: We report on a primary cutaneous rhabdoid tumour in a 14-month-old child, to the best of our knowledge, the second case in the literature. The tumour showed a multipolypoid gross appearance and classical histological features. The neoplastic cells were positive for keratin and vimentin and most were positive for proliferating cell nuclear antigen. The ultrastructural examination revealed typical intracytoplasmic aggregates of intermediate filaments. The tumour showed a very aggressive course, and the child died 5 months after the diagnosis of cerebral metastasis.
authors.affiliation: Institute of Pathology, 2nd Faculty of Medicine, University of Naples Federico II, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Boscaino
authors.forename: V
authors.initials: V
authors.lastname: Donofrio
authors.forename: L
authors.initials: L
authors.lastname: Tornillo
authors.forename: S
authors.initials: S
authors.lastname: Staibano
authors.forename: G
authors.initials: G
authors.lastname: De Rosa
mesh_terms: D001932:Brain Neoplasms / Q000556:secondary; D002466:Cell Nucleolus / Q000648:ultrastructure; D002467:Cell Nucleus / Q000648:ultrastructure; D003593:Cytoplasm / Q000648:ultrastructure; D017809:Fatal Outcome; D006801:Humans; D006818:Hyalin / Q000648:ultrastructure; D007150:Immunohistochemistry; D002479:Inclusion Bodies / Q000648:ultrastructure; D007223:Infant; D007382:Intermediate Filaments / Q000648:ultrastructure; D007633:Keratins / Q000032:analysis; D008297:Male; D015388:Organelles / Q000648:ultrastructure; D018335:Rhabdoid Tumor / Q000151:congenital* / Q000473:pathology* / Q000556:secondary / Q000648:ultrastructure; D012878:Skin Neoplasms / Q000151:congenital* / Q000473:pathology* / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis
chemical_list: D014746:Vimentin; D007633:Keratins