Adhesive signaling in platelets.
The anucleate platelet must perform its hemostatic functions in the absence of transcriptional regulation. Central among these functions is cell adhesion, which is mediated by multiple specialized plasma membrane receptors. The adhesive function of one of the key receptors, integrin alpha IIb beta 3, is regulated by intracellular signals triggered by platelet agonists and antagonists. Recent evidence indicates that adhesion receptors can transduce extracellular signals into the platelet to activate intracellular signaling pathways that affect hemostasis.
Shattil
S J
SJ
Division of Hematology-Oncology, University of Pennsylvania Medical Center, Philidelphia 19104.
Ginsberg
M H
MH
Brugge
J S
JS
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000502:physiology; D005340:Fibrinogen / Q000737:chemistry / Q000502:physiology; D006801:Humans; D019012:Integrin beta1; D016023:Integrins / Q000502:physiology; D008024:Ligands; D008954:Models, Biological; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry; D019000:Phosphotyrosine; D010973:Platelet Adhesiveness / Q000502:physiology*; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D010980:Platelet Membrane Glycoproteins / Q000502:physiology; D016024:Receptors, Cytoadhesin / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology; D014443:Tyrosine / Q000031:analogs & derivatives / Q000502:physiology
D015703:Antigens, CD; D019012:Integrin beta1; D016023:Integrins; D008024:Ligands; D009842:Oligopeptides; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D010980:Platelet Membrane Glycoproteins; D016024:Receptors, Cytoadhesin; D019000:Phosphotyrosine; D014443:Tyrosine; C047981:arginyl-glycyl-aspartic acid; D005340:Fibrinogen