title: Induction of transcription factor AP2 mRNA expression in rat primary afferent neurons during acute inflammation.
abstract: We have examined immediate early gene mRNA expression, using in situ hybridisation in innervating dorsal root ganglion (DRG) neurons following peripheral adjuvant injection. Neuronal expression of mRNAs encoding NGFI-A (nerve growth factor-induced), NGFI-B, c-jun, jun D and jun B was undetectable in untreated controls and was unchanged following adjuvant injection. AP-2 mRNA was expressed in the majority of DRG neurons in untreated controls and was significantly increased (217 +/- 43% control) 1 h after adjuvant injection. AP2 mRNA levels returned to control values by 2 h post-injection. AP-2 may form part of the early transcriptional response that induces neuropeptide gene expression in DRG after adjuvant injection.
authors.affiliation: Department of Medicine, Western General Hospital, University of Edinburgh, UK.
authors.forename: L F
authors.initials: LF
authors.lastname: Donaldson
authors.forename: D S
authors.initials: DS
authors.lastname: McQueen
authors.forename: J R
authors.initials: JR
authors.lastname: Seckl
mesh_terms: D000208:Acute Disease; D000818:Animals; D001169:Arthritis, Experimental / Q000378:metabolism* / Q000473:pathology; D004268:DNA-Binding Proteins / Q000235:genetics*; D005727:Ganglia, Spinal / Q000378:metabolism / Q000473:pathology; D017781:Genes, Immediate-Early; D008297:Male; D009475:Neurons, Afferent / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000235:genetics*
chemical_list: D004268:DNA-Binding Proteins; D050656:Transcription Factor AP-2; D014157:Transcription Factors