title: Antibody response to a Babesia bigemina rhoptry-associated protein 1 surface-exposed and neutralization-sensitive epitope in immune cattle.
abstract: Protective immunity against Babesia bigemina is hypothesized to involve antibodies directed against merozoite surface-exposed epitopes. Levels of antibody against a rhoptry-associated protein 1 (RAP-1) B-lymphocyte epitope, defined by surface-reactive and inhibitory monoclonal antibodies, in immune cattle sera were determined. All cattle produced antibodies to the epitope; however, there was limited correlation between immune protection induced by infection or RAP-1 immunization and the level of antibody to the neutralization-sensitive B-lymphocyte epitope examined.
authors.affiliation: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164-7040.
authors.forename: T C
authors.initials: TC
authors.lastname: Ushe
authors.forename: G H
authors.initials: GH
authors.lastname: Palmer
authors.forename: L
authors.initials: L
authors.lastname: Sotomayor
authors.forename: J V
authors.initials: JV
authors.lastname: Figueroa
authors.forename: G M
authors.initials: GM
authors.lastname: Buening
authors.forename: L E
authors.initials: LE
authors.lastname: Perryman
authors.forename: T F
authors.initials: TF
authors.lastname: McElwain
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan / Q000096:biosynthesis*; D000953:Antigens, Protozoan / Q000276:immunology*; D001403:Babesia / Q000145:classification; D001404:Babesiosis / Q000276:immunology* / Q000517:prevention & control; D002417:Cattle; D002418:Cattle Diseases / Q000276:immunology* / Q000517:prevention & control; D000939:Epitopes / Q000276:immunology; D008565:Membrane Proteins / Q000276:immunology; D009500:Neutralization Tests; D015800:Protozoan Proteins / Q000276:immunology*; D013045:Species Specificity; D014611:Vaccination
chemical_list: D000911:Antibodies, Monoclonal; D000913:Antibodies, Protozoan; D000953:Antigens, Protozoan; D000939:Epitopes; D008565:Membrane Proteins; D015800:Protozoan Proteins; C065352:rhoptry associated protein, Plasmodium