Uterine carcinomas in mother cats after intrafetal inoculation of allogeneic tumor cells (K248 C and P).
Three out of 13 queens that had undergone injection of tumor cells from an allogeneic feline mammary carcinoma cell line through the wall of the pregnant uterus developed a carcinoma of the uterus. The possible role of immune tolerance associated with pregnancy and/or major histocompatibility complex (MHC) compatibility is discussed.
Minke
J M
JM
Department of Pathology, Faculty of Veterinary Medicine, University of Utrecht, Netherlands.
Hensen
E J
EJ
Misdorp
W
W
D000818:Animals; D002277:Carcinoma / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D002371:Cat Diseases / Q000276:immunology / Q000473:pathology*; D002415:Cats; D005260:Female; D005333:Fetus; D005500:Follow-Up Studies; D007108:Immune Tolerance; D007267:Injections / Q000662:veterinary; D008285:Major Histocompatibility Complex / Q000276:immunology; D008325:Mammary Neoplasms, Experimental / Q000276:immunology / Q000473:pathology*; D009362:Neoplasm Metastasis; D009368:Neoplasm Transplantation / Q000662:veterinary; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000276:immunology / Q000473:pathology / Q000662:veterinary*; D014184:Transplantation, Homologous / Q000662:veterinary; D014407:Tumor Cells, Cultured; D014594:Uterine Neoplasms / Q000276:immunology / Q000473:pathology / Q000662:veterinary*