[Clinical experiences of granulocyte colony stimulating factor for granulocytopenia after AC bypass].
We have successfully treated 3 cases of granulocytopenia, using Granulocyte Colony Stimulating Factor (G-CSF) after AC bypass surgery. All cases were male, aged 68, 75 & 54 years old, and underwent AC bypass surgery without transfusion except in case 1. Granulocyte cell counts decreased to 135/mm3 on 39th post-operative days (POD) in case 1, 624/mm3 on 13 rd POD in case 2, and 514/mm3 on 20th POD in case 3. In case 1, 300 micrograms of G-CSF was given intravenously for 3 days. In case 2, 100 micrograms of G-CSF for 1 day and 50 micrograms for 3 days was given subcutaneously, and in case 3, 100 micrograms of G-CSF was also given subcutaneously for 2 days. And their granulocyte cell counts all increased within few days. G-CSF is effective for patients with granulocytopenia after AC bypass surgery, but we need more experiences to know the best way of administration.
Yamamura
M
M
Department of Surgery, Cardiovascular Institute, Tokyo, Japan.
Aoki
K
K
Asakura
T
T
Tadokoro
M
M
Furuta
S
S
Kashiwagi
H
H
Itoh
H
H
Sagara
K
K
Abe
S
S
Asakawa
H
H
D000368:Aged; D000380:Agranulocytosis / Q000628:therapy*; D000787:Angina Pectoris / Q000601:surgery; D001026:Coronary Artery Bypass; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000628:therapy*
D016179:Granulocyte Colony-Stimulating Factor