The CSF myelin basic protein: a reliable marker of actual cerebral damage in hydrocephalus.
Raised ventricular CSF myelin basic protein (MBP) concentration has been evidenced in 17 shunted hydrocephalic patients. Contemporary evaluation both from ventricular and lumbar CSF samples showed a concentration ratio of 20:1. In all cases the raised values of ventricular CSF concentration of MBP demonstrated a significant decrease after shunt operation. This preliminary report suggests that this marker is an important index of actual brain damage in hydrocephalus and could be taken in account for the indication of shunt operation.
Longatti
P L
PL
Servizio di Medicina Nucleare, Università di Padova, Ospedale Regionale di Treviso, Italy.
Canova
G
G
Guida
F
F
Carniato
A
A
Moro
M
M
Carteri
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001925:Brain Damage, Chronic / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis*; D002675:Child, Preschool; D006801:Humans; D006849:Hydrocephalus / Q000134:cerebrospinal fluid* / Q000150:complications / Q000601:surgery; D007427:Intracranial Pressure; D008875:Middle Aged; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid*; D017287:Ventriculoperitoneal Shunt
D015415:Biomarkers; D004676:Myelin Basic Protein