Clorgyline effect on pineal melatonin biosynthesis in Roman high- and low-avoidance rats.
Pineal melatonin and related indoles levels were higher in Roman high- than in Roman low-avoidance rats, while 5-HIAA/5-HT ratio, as an index of MAO activity was higher in low- than in high-avoidance rats. Clorgyline stimulated pineal melatonin biosynthesis in both lines of rats. However, melatonin and N-acetylserotonin levels remained higher and 5-HIAA levels remained lower in the high avoidance rats treated with low dose (0.5 mg/kg) while treatment with 1.0 mg/kg of clorgyline eliminated the differences in melatonin production between high- and low-avoidance rats.
Requintina
P J
PJ
Pineal Research Laboratory, VAMC, Providence, Rhode Island.
Driscoll
P
P
Oxenkrug
G F
GF
D000818:Animals; D001362:Avoidance Learning / Q000502:physiology*; D003010:Clorgyline / Q000494:pharmacology*; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008297:Male; D008550:Melatonin / Q000096:biosynthesis*; D010870:Pineal Gland / Q000378:metabolism*; D051381:Rats; D011919:Rats, Inbred Strains / Q000378:metabolism* / Q000523:psychology*; D012701:Serotonin / Q000031:analogs & derivatives / Q000378:metabolism
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D008550:Melatonin; D003010:Clorgyline; C006389:N-acetylserotonin