title: The association between enteric bacterial overgrowth and gastrointestinal motility after subtotal liver resection or portal vein obstruction in rats.
abstract: OBJECTIVE
  To test the hypothesis that intestinal motility is delayed after hepatectomy, which alters the ecology of the enteric microflora and contributes to the development of bacterial translocation from the gut.
  
  
  METHODS
  Open experimental study.
  
  
  METHODS
  University department of surgery.
  
  
  METHODS
  Adult male Sprague-Dawley rats (n = 6 in each group at each time point).
  
  
  METHODS
  Sham operation, 90% hepatectomy, and portal venous obstruction.
  
  
  METHODS
  Intestinal morphology, immunocytochemistry of the enteric nervous system, enteric bacterial growth in the small intestine and colon, and intestinal transit time.
  
  
  RESULTS
  Intestinal transit was already delayed one hour after 90% hepatectomy, and histopathological alterations and overgrowth by Escherichia Coli had developed after two hours. There were significant differences in intestinal transit time between sham operated rats and those subjected to portal venous obstruction on the one hand, and those that underwent 90% hepatectomy on the other. There was no difference in intestinal transit time between rats with portal venous obstruction and the sham operated animals.
  
  
  CONCLUSIONS
  Delayed intestinal transit after 90% hepatectomy may contribute to enteric bacterial overgrowth and thereby contribute to the development of bacterial translocation from the gut.
authors.affiliation: Department of Surgery, Lund University, Sweden.
authors.forename: X D
authors.initials: XD
authors.lastname: Wang
authors.forename: W D
authors.initials: WD
authors.lastname: Guo
authors.forename: Q
authors.initials: Q
authors.lastname: Wang
authors.forename: R
authors.initials: R
authors.lastname: Andersson
authors.forename: E
authors.initials: E
authors.lastname: Ekblad
authors.forename: V
authors.initials: V
authors.lastname: Soltesz
authors.forename: S
authors.initials: S
authors.lastname: Bengmark
mesh_terms: D000818:Animals; D002432:Cecum / Q000502:physiology; D002860:Chromium Radioisotopes; D003106:Colon / Q000737:chemistry / Q000382:microbiology / Q000473:pathology / Q000502:physiology; D004386:Duodenum / Q000737:chemistry / Q000382:microbiology / Q000473:pathology; D017615:Enteric Nervous System / Q000473:pathology; D004755:Enterobacteriaceae / Q000254:growth & development* / Q000302:isolation & purification; D004926:Escherichia coli / Q000254:growth & development / Q000302:isolation & purification; D005769:Gastrointestinal Motility / Q000502:physiology*; D006498:Hepatectomy; D006975:Hypertension, Portal / Q000382:microbiology / Q000503:physiopathology*; D007082:Ileum / Q000737:chemistry / Q000382:microbiology / Q000473:pathology; D007583:Jejunum / Q000382:microbiology / Q000473:pathology / Q000502:physiology; D008297:Male; D009478:Neuropeptide Y / Q000032:analysis; D011169:Portal Vein / Q000601:surgery*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013373:Substance P / Q000032:analysis; D014660:Vasoactive Intestinal Peptide / Q000032:analysis
chemical_list: D002860:Chromium Radioisotopes; D009478:Neuropeptide Y; D013373:Substance P; D014660:Vasoactive Intestinal Peptide