[Significance of AgNOR analysis of urothelial carcinomas].
Biopsies of normal and atypical/dysplastic epithelium of the urinary bladder as well as transitional cell carcinomas grades I to III were stained with a silver nitrate solution, and the silver-stained nucleolar organizer regions were evaluated. The AgNOR-analysis shows highly significant differences in the G II subgroups, similar to the results of nucleolar subgrading. Because of the significantly differing 5-year survival rates, it can be justified to divide transitional cell carcinomas into two groups: a low-risk group with favorable prognosis (G Ia to G IIa), and a high-risk group with poor prognosis (G IIb to G IIIa,b).
Helpap
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Institut für Pathologie, Singen.
Loesevitz
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D001706:Biopsy; D002295:Carcinoma, Transitional Cell / Q000401:mortality / Q000473:pathology*; D004848:Epithelium / Q000473:pathology; D006652:Histological Techniques; D006801:Humans; D009697:Nucleolus Organizer Region / Q000473:pathology* / Q000648:ultrastructure; D011379:Prognosis; D012835:Silver Nitrate; D015996:Survival Rate; D001743:Urinary Bladder / Q000473:pathology*; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000473:pathology*
D012835:Silver Nitrate