title: Compatibility and stability of ondansetron hydrochloride with morphine sulfate and with hydromorphone hydrochloride in 0.9% sodium chloride injection at 4, 22, and 32 degrees C.
abstract: The physical compatibility and chemical stability of ondansetron hydrochloride 0.1 and 1 mg/mL with morphine sulfate 1 mg/mL and with hydromorphone hydrochloride 0.5 mg/mL in 0.9% sodium chloride injection were studied. Test solutions of the drugs in 0.9% sodium chloride injection were prepared in triplicate and stored at 4, 22, and 32 degrees C. Samples were removed immediately and at various time points over 31 days and stored at -70 degrees C until analyzed. Physical compatibility was assessed visually and by measuring turbidity with a color-correcting turbidimeter and particle content with a light-obscuration particle sizer and counter. Chemical stability was determined by measuring the concentration of each drug in duplicate with stability-indicating high-performance liquid chromatography. There were no visual or subvisual changes in turbidity or particle content in any of the test solutions at any of the time points. There was little or no loss of any of the drugs. When admixed in 0.9% sodium chloride injection, ondansetron hydrochloride 0.1 and 1 mg/mL plus morphine sulfate 1 mg/mL or hydromorphone hydrochloride 0.5 mg/mL were compatible and stable for at least 7 days at 32 degrees C and for at least 31 days at 4 and 22 degrees C.
authors.affiliation: Division of Pharmacy, University of Texas M. D. Anderson Cancer Center, Houston 77030.
authors.forename: L A
authors.initials: LA
authors.lastname: Trissel
authors.forename: Q
authors.initials: Q
authors.lastname: Xu
authors.forename: J F
authors.initials: JF
authors.lastname: Martinez
authors.forename: J L
authors.initials: JL
authors.lastname: Fox
mesh_terms: D002851:Chromatography, High Pressure Liquid; D004344:Drug Incompatibility; D004355:Drug Stability; D006801:Humans; D004091:Hydromorphone / Q000737:chemistry*; D009020:Morphine / Q000737:chemistry*; D017294:Ondansetron / Q000737:chemistry*; D012965:Sodium Chloride / Q000737:chemistry*; D013696:Temperature
chemical_list: D012965:Sodium Chloride; D017294:Ondansetron; D009020:Morphine; D004091:Hydromorphone