Activation of lamina propria T lymphocytes in Crohn's disease.
Crohn's disease is characterized by chronic inflammatory infiltrates and granuloma formation in the gut. T cell directed immunotherapy appears to be effective in relieving these symptoms. Under normal conditions, lamina propria T lymphocytes have a low proliferative response to antigen receptor stimulation in vitro due to the influence of the local intestinal environment. This study shows that lamina propria T lymphocytes exhibit an enhanced response to antigen receptor stimulation in active Crohn's disease, which may contribute in its pathogenesis.
Qiao
L
L
Applied Immunology, German Cancer Research Center, Heidelberg.
Schürmann
G
G
Meuer
S C
SC
Autschbach
F
F
D017252:CD3 Complex / Q000378:metabolism; D016022:Case-Control Studies; D003424:Crohn Disease / Q000209:etiology / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D006801:Humans; D018928:Immunity, Mucosal; D066298:In Vitro Techniques; D007376:Interleukin-2 / Q000096:biosynthesis; D007413:Intestinal Mucosa / Q000276:immunology; D008213:Lymphocyte Activation; D013601:T-Lymphocytes / Q000276:immunology*
D017252:CD3 Complex; D007376:Interleukin-2