Impaired G-CSF production at post-transcriptional level in a patient with chronic idiopathic neutropenia.
Chronic idiopathic neutropenia (CIN) is a disorder characterized by severe neutropenia and a maturational arrest of the neutrophil precursors in the bone marrow. The pathogenesis of this disorder has been obscure. We examined the production of endogenous G-CSF and the expression of G-CSFmRNA in a patient with adult type CIN. The G-CSF production by the patient's mononuclear cells was deficient in spite of the adequate accumulation of G-CSFmRNA. Our data suggests that the defect in the endogenous G-CSF production at the post-transcriptional level is likely to be an aetiological factor in CIN.
Morikawa
K
K
Department of Internal Medicine, Shimane Medical University.
Yamamori
S
S
Oiwa
K
K
Morikawa
S
S
Oseko
F
F
Kubota
T
T
Nakamura
T
T
D000368:Aged; D002478:Cells, Cultured; D002908:Chronic Disease; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D008297:Male; D009000:Monocytes / Q000378:metabolism; D009503:Neutropenia / Q000097:blood* / Q000209:etiology / Q000235:genetics; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis; D014158:Transcription, Genetic
D012333:RNA, Messenger; D016179:Granulocyte Colony-Stimulating Factor