Is urodilatin (rather than atriopeptin) the primary natriuretic peptide of the ANP family?
This article summarizes evidence supporting the hypothesis that urodilatin, rather than atriopeptin, is the member of the atrial natriuretic peptide family primarily involved in the regulation of renal sodium excretion. A number of lines of evidence imply that atriopeptin is only of trivial importance in the regulation of sodium excretion during normal living conditions. On the other hand, urodilatin, which is produced in the kidneys, has properties very similar to atriopeptin. Moreover, its excretion in the urine appears to correlate quite closely with the concomitant excretion of sodium.
Goetz
K L
KL
St. Luke's Hospital and Foundation, Kansas City, Missouri 64111.
D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology*; D004285:Dogs; D006801:Humans; D009318:Natriuresis; D010446:Peptide Fragments / Q000502:physiology*; D012964:Sodium / Q000652:urine
D010446:Peptide Fragments; C056452:Ularitide; D009320:Atrial Natriuretic Factor; D012964:Sodium