title: [The determination of the antigenic determinant of protective monoclonal antibodies specific to the Francisella tularensis lipopolysaccharide].
abstract: F. tularensis lipopolysaccharide (LPS) was studied with the use of monoclonal antibodies (McAb) having protective properties. The binding site of these McAb (IgG2a) is localized on the O-chain of LPS. In contrast to LPS isolated from vaccine strain 15, LPS isolated from F. tularensis cells in the R-form has no O-chains and does not interact with McAb.
authors.forename: V S
authors.initials: VS
authors.lastname: Khlebnikov
authors.forename: I R
authors.initials: IR
authors.lastname: Golovlev
authors.forename: N V
authors.initials: NV
authors.lastname: Tokhtamysheva
authors.forename: S F
authors.initials: SF
authors.lastname: Averin
authors.forename: D P
authors.initials: DP
authors.lastname: Kulevatskiĭ
authors.forename: G K
authors.initials: GK
authors.lastname: Grechko
authors.forename: A A
authors.initials: AA
authors.lastname: Averina
authors.forename: S S
authors.initials: SS
authors.lastname: Vetchinin
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis* / Q000302:isolation & purification; D000911:Antibodies, Monoclonal / Q000032:analysis* / Q000302:isolation & purification; D000918:Antibody Specificity; D001666:Binding Sites, Antibody / Q000276:immunology; D000939:Epitopes / Q000032:analysis* / Q000302:isolation & purification; D005604:Francisella tularensis / Q000276:immunology* / Q000472:pathogenicity; D006825:Hybridomas / Q000276:immunology; D007158:Immunologic Techniques; D008070:Lipopolysaccharides / Q000276:immunology* / Q000302:isolation & purification; D051379:Mice; D008807:Mice, Inbred BALB C; D012692:Serial Passage; D014774:Virulence / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000939:Epitopes; D008070:Lipopolysaccharides