Direct analysis of tumor-associated peptide antigens.
Adoptive immunotherapy with tumor-specific cytotoxic T lymphocytes (CTLs) can induce tumor regressions in animals and in human cancer patients. Antigens recognized by CTLs from cancer patients are being sought as possible immunogens, a number of which have been identified during the past year. The ultimate result may be the development of novel peptide-based immunotherapies and a new understanding of the T-cell response to human cancer.
Slingluff
C L
CL
University of Virginia Health Sciences Center, Charlottesville.
Hunt
D F
DF
Engelhard
V H
VH
D000595:Amino Acid Sequence; D000818:Animals; D000951:Antigens, Neoplasm / Q000096:biosynthesis / Q000737:chemistry / Q000276:immunology*; D000939:Epitopes / Q000032:analysis / Q000276:immunology; D006801:Humans; D008545:Melanoma / Q000276:immunology; D008969:Molecular Sequence Data; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D000951:Antigens, Neoplasm; D000939:Epitopes; D010455:Peptides