title: Changes in serum amylase level following hepatic resection in chronic liver disease.
abstract: OBJECTIVE
  Factors that were likely to cause hyperamylasemia following hepatic resection were studied.
  
  
  METHODS
  Case-comparison study.
  
  
  METHODS
  Institutional practice.
  
  
  METHODS
  Seventy-one patients who underwent hepatic resection because of primary or secondary liver tumors and other benign disease, and who had no history of pancreatitis, were divided into four groups. Patients were divided into groups according to the presence or absence of underlying liver disease and the vascular occlusion methods used during hepatic resection (Pringle maneuver or the hemihepatic vascular occlusion technique). The Pringle maneuver was chosen for patients in whom the duration of liver parenchymal transection was expected to be short and/or the hepatic hilum had severe adhesion precluding the safe dissection of the hepatic artery and portal vein.
  
  
  METHODS
  Serum amylase levels were measured on the preoperative day and on postoperative days 1, 2, 4, 6, 7, 10, and 14. Preoperative liver function, operative blood loss, operative time, and vascular occlusion time were examined.
  
  
  RESULTS
  Patients with chronic liver disease (CLD group) had high serum amylase levels during the preoperative and postoperative periods. Patients in the CLD group who underwent the Pringle maneuver (Pringle-L group) had significantly elevated postoperative serum amylase levels in comparison with their preoperative serum amylase levels. Pancreatitis developed in two patients in the Pringle-L group--one of them died.
  
  
  CONCLUSIONS
  These results strongly suggest that prolonged complete occlusion of the portal vein for hepatectomy in patients with chronic liver disease has a serious influence on postoperative serum amylase levels.
authors.affiliation: First Department of Surgery, Shinshu University, School of Medicine, Matsumoto, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Miyagawa
authors.forename: M
authors.initials: M
authors.lastname: Makuuchi
authors.forename: S
authors.initials: S
authors.lastname: Kawasaki
authors.forename: T
authors.initials: T
authors.lastname: Kakazu
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000681:Amylases / Q000097:blood*; D000704:Analysis of Variance; D016063:Blood Loss, Surgical; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000401:mortality / Q000601:surgery; D016022:Case-Control Studies; D002908:Chronic Disease; D005112:Extracorporeal Circulation / Q000009:adverse effects* / Q000379:methods; D005260:Female; D006498:Hepatectomy / Q000009:adverse effects* / Q000379:methods; D006509:Hepatitis B / Q000097:blood* / Q000401:mortality / Q000601:surgery; D006526:Hepatitis C / Q000097:blood* / Q000401:mortality / Q000601:surgery; D006801:Humans; D008102:Liver Circulation; D008103:Liver Cirrhosis / Q000097:blood* / Q000401:mortality / Q000601:surgery; D008111:Liver Function Tests; D008113:Liver Neoplasms / Q000097:blood* / Q000401:mortality / Q000601:surgery; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D012307:Risk Factors; D015996:Survival Rate; D013997:Time Factors
chemical_list: D000681:Amylases