title: Detection of naphthols and aflatoxins in Nigerian cord blood.
abstract: Widespread use of napthol-containing compounds and frequent contamination of foods by aflatoxins occurs in Nigeria. Napthols cause haemolysis and aflatoxins are hepatotoxic. A study was carried out to determine the extent of fetal exposure to these compounds and their influence on birthweight. Cord blood samples were collected at delivery from 625 babies and their sera were analysed for aflatoxins and naphthols. Mothers' histories and babies' weights were recorded. Naphthols were detected in 6.9% and aflatoxins in 14.6% of serum samples. No correlation was found between the presence of either compound and birthweight. Reported exposure to naphthalene-containing compounds was not related to detection of serum naphthol. Results show considerable fetal exposure to these potentially toxic compounds in Ibadan, Nigeria.
authors.affiliation: Liverpool School of Tropical Medicine, UK.
authors.forename: S M
authors.initials: SM
authors.lastname: Maxwell
authors.forename: J B
authors.initials: JB
authors.lastname: Familusi
authors.forename: O
authors.initials: O
authors.lastname: Sodeinde
authors.forename: M C
authors.initials: MC
authors.lastname: Chan
authors.forename: R G
authors.initials: RG
authors.lastname: Hendrickse
mesh_terms: D000348:Aflatoxins / Q000097:blood*; D001724:Birth Weight; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D009284:Naphthols / Q000097:blood*; D009549:Nigeria; D011247:Pregnancy
chemical_list: D000348:Aflatoxins; D009284:Naphthols; C029350:1-naphthol; C028405:2-naphthol