[Forgetfulness and amnesia: receptor mechanisms and brain mapping].
Inability to remember and amnesia have been shown to be active neurochemical processes. The coupled processes (blockade of the triggering DA stimulating system and activation of the inhibitory GABA-ergic system with the predominant value of postsynaptic D-2 receptors) are a neurochemical basis for development of amnesia. The mechanisms of spontaneous forgetting is provided by a decrease in the activity of the dopaminergic system along with the enhancement of benzodiazepine-GABA-ergic interferentional inhibition. The observed changes in dopamine metabolism, para-tyramine appearance, as well as restructure of D-2 receptors provide the activity of dopamine increasing mechanism which determines the retention of memory traces. A computer model of the spatial interaction of the dopamine membrane-receptor complex was constructed by scanning the samples of synaptic membranes after learning and amnesia. A new method of inducing psychogenic amnesia in human beings has been elaborated. Amnesia is characterized by the absence of increases in the number of cortical connections reflecting the emotional factor of information.
Ilíuchenok
R Iu
RIu
Dubrovina
N I
NI
Podgornaia
O V
OV
Galkina
O V
OV
D000647:Amnesia / Q000503:physiopathology*; D003198:Computer Simulation; D006801:Humans; D008569:Memory Disorders / Q000503:physiopathology*; D017448:Receptors, Dopamine D2 / Q000502:physiology*
D017448:Receptors, Dopamine D2