title: Salmeterol inhibits anaphylactic histamine release from guinea-pig isolated mast cells.
abstract: Salmeterol (1 nM-100 microM) showed an inhibitory action on anaphylactic histamine release from mast cells, isolated from pleural and peritoneal cavities of actively sensitized guinea-pigs and stimulated by incubation with allergen. The effect is concentration-dependent and is reduced by the beta-adrenoceptor antagonist propranolol (1 microM). This study supports the hypothesis of an anti-inflammatory property of salmeterol, which concerns cells involved in the early phases of asthma.
authors.affiliation: Department of Preclinical and Clinical Pharmacology, University of Florence, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Gentilini
authors.forename: M
authors.initials: M
authors.lastname: Grazia di Bello
authors.forename: S
authors.initials: S
authors.lastname: Raspanti
authors.forename: D
authors.initials: D
authors.lastname: Bindi
authors.forename: S
authors.initials: S
authors.lastname: Mugnai
authors.forename: L
authors.initials: L
authors.lastname: Zilletti
mesh_terms: D000318:Adrenergic beta-Agonists / Q000494:pharmacology*; D000420:Albuterol / Q000031:analogs & derivatives* / Q000494:pharmacology; D000707:Anaphylaxis / Q000188:drug therapy*; D000818:Animals; D005470:Fluorometry; D006168:Guinea Pigs; D006633:Histamine Antagonists / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D066298:In Vitro Techniques; D008297:Male; D008407:Mast Cells / Q000187:drug effects*; D010529:Peritoneal Cavity / Q000166:cytology; D010994:Pleura / Q000166:cytology; D011433:Propranolol / Q000494:pharmacology; D000068299:Salmeterol Xinafoate
chemical_list: D000318:Adrenergic beta-Agonists; D006633:Histamine Antagonists; D000068299:Salmeterol Xinafoate; D011433:Propranolol; D000420:Albuterol