title: A generalized ionic model of the neuronal membrane electrical activity.
abstract: A new ionic model of the neuronal-membrane electrical activity has been developed. The proposed model generalizes those usually quoted in the literature, taking into account the significant ionic currents, the temperature dependence of the electrical parameters, and the stochastic synaptic inputs. The model allows us to simulate both the membrane firing activity, as a function of the temperature, and the membrane resistance behavior, as a function of temperature and of intracellular calcium concentration. The I-V nonlinear characteristic, together with histograms and correlograms of the time intervals between spikes, have been numerically reproduced. Various comparisons we have carried out with available experimental data show a good theoretical-experimental agreement.
authors.affiliation: Department of Electronic Engineering, La Sapienza University of Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Bernardi
authors.forename: G
authors.initials: G
authors.lastname: D'Inzeo
authors.forename: S
authors.initials: S
authors.lastname: Pisa
mesh_terms: D002118:Calcium / Q000378:metabolism; D002462:Cell Membrane / Q000502:physiology; D004553:Electric Conductivity; D007473:Ion Channels / Q000502:physiology*; D008564:Membrane Potentials; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D011188:Potassium / Q000378:metabolism; D012016:Reference Values; D012964:Sodium / Q000378:metabolism; D013269:Stochastic Processes; D013569:Synapses / Q000502:physiology; D013696:Temperature
chemical_list: D007473:Ion Channels; D012964:Sodium; D011188:Potassium; D002118:Calcium