The rodent dominant lethal assay: regulatory questions concerning appraisal of an industrial chemical as exemplified by 1,3-butadiene.
Ashby has recently described a clear diagrammatic model for the presentation and assessment of test data from dominant lethal tests. From a regulatory perspective, this approach has the merit of providing data in a standard format. Having recently evaluated the dominant lethal test data for butadiene, we have identified several areas for consideration and discussion.
Brooke
I M
IM
Smith
A J
AJ
D000818:Animals; D002070:Butadienes / Q000633:toxicity*; D002617:Chemical Industry; D005260:Female; D005799:Genes, Dominant / Q000187:drug effects*; D005804:Genes, Lethal / Q000187:drug effects*; D008297:Male; D051379:Mice; D009153:Mutagens / Q000633:toxicity*; D016273:Occupational Exposure; D011247:Pregnancy / Q000187:drug effects
D002070:Butadienes; D009153:Mutagens; C031763:1,3-butadiene