[The participation of opioid peptides in forming the nonspecific protective reactions of the body].
The mechanisms of action of the opioid system on forming the nonspecific protective reactions of the body were investigated in rabbits and CBA mice injected the native preparation interleukin-1 (IL-1) of the rabbit after preinjection to the same animals with synthetic analog of leu-enkephalin--dalargin (D) or naloxone. Injection of D with IL-I to mice produced a 1.5 lower content of C-reactive protein (CRP) than in the control. Naloxone injected with saline or D prior to IL 1, prevented IL-1-induced rise in CRP level. The property of IL-1 was found to slow down process of summation of peripheral nociceptive impulses in the CNS of rabbits after i.v. injection the pyrogenic dose of IL-1. The preinjection of naloxone blocked these phenomenon and pyrogenic effect of IL-1 in the rabbits. The effects observed are supposed to result from the interaction of leukopeptides and opioid peptides at the level of cell receptors.
Gritskevich
N L
NL
Korneva
E A
EA
D000209:Acute-Phase Proteins / Q000032:analysis / Q000187:drug effects; D000818:Animals; D002097:C-Reactive Protein / Q000032:analysis / Q000187:drug effects; D004347:Drug Interactions; D004723:Endorphins / Q000502:physiology*; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives / Q000494:pharmacology; D007113:Immunity, Innate / Q000187:drug effects / Q000502:physiology*; D007375:Interleukin-1 / Q000494:pharmacology; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D009270:Naloxone / Q000494:pharmacology; D011817:Rabbits; D013997:Time Factors
D000209:Acute-Phase Proteins; D004723:Endorphins; D007375:Interleukin-1; D009270:Naloxone; D016308:Enkephalin, Leucine-2-Alanine; D002097:C-Reactive Protein; C040996:enkephalin-Leu, Ala(2)-Arg(6)-