title: Aprotinin does not decrease early graft patency after coronary artery bypass grafting despite reducing postoperative bleeding and use of donated blood.
abstract: Forty-five male patients with planned coronary artery bypass operation were randomized in a double blind fashion to receive either 6 million kallikrein inactivator units of aprotinin (high-dose group), 2 million kallikrein inactivator units of aprotinin (low-dose group), or placebo (control group). Postoperative bleeding was significantly decreased in both aprotinin groups in comparison to that in the control group (590 ml [290 to 1800 ml] high-dose group and 650 ml [280 to 1900 ml] low-dose group versus 920 ml (350 to 2700 ml) control group, p < 0.001). There was no difference between the two aprotinin groups. The need for postoperative blood transfusion was significantly lower in the aprotinin groups (1.46 [0 to 4] blood units high-dose group and 1.65 [0 to 5] blood units low-dose group versus 2.43 [0 to 7] blood units control group, p < 0.05). All patients underwent coronary angiography between the seventh and twelfth postoperative day. No difference was found among the three groups in patency of vein grafts-93.8% in the high-dose group, 94.5% in the low-dose groups, and 93.3% in the control group. Therefore, aprotinin significantly reduced postoperative bleeding and transfusion requirement after coronary artery bypass grafting without influencing early graft patency.
authors.affiliation: Second Department of Surgery, University Hospital of Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Havel
authors.forename: F
authors.initials: F
authors.lastname: Grabenwöger
authors.forename: J
authors.initials: J
authors.lastname: Schneider
authors.forename: G
authors.initials: G
authors.lastname: Laufer
authors.forename: G
authors.initials: G
authors.lastname: Wollenek
authors.forename: A
authors.initials: A
authors.lastname: Owen
authors.forename: P
authors.initials: P
authors.lastname: Simon
authors.forename: H
authors.initials: H
authors.lastname: Teufelsbauer
authors.forename: E
authors.initials: E
authors.lastname: Wolner
mesh_terms: D007611:Aprotinin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D001803:Blood Transfusion; D017023:Coronary Angiography; D001026:Coronary Artery Bypass; D004311:Double-Blind Method; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging; D006470:Hemorrhage / Q000517:prevention & control*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D013997:Time Factors
chemical_list: D007611:Aprotinin