Predicting the severity of rhesus alloimmunization: monocyte-mediated chemiluminescence versus maternal anti-D antibody estimation.
Anti-D haemolytic antibody concentration and chemiluminescence (CLT) opsonic index was measured in maternal blood obtained from 20 alloimmunized pregnancies at 17-28 weeks undergoing intrauterine fetal blood sampling for the estimation of fetal haemoglobin concentration. The fetal haemoglobin concentration was significantly associated with the maternal serum CLT opsonic index (r = -0.566, P < 0.01) but not with the maternal anti-D concentration (r = -0.329). The data of this study indicate that measurement of maternal serum CLT opsonic index may be more accurate than anti-D quantification in providing non-invasive prediction of the degree of fetal anaemia.
Buggins
A G
AG
Department of Haematology, Kings College Hospital Medical School, London.
Thilaganathan
B
B
Hambley
H
H
Nicolaides
K H
KH
D000740:Anemia / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005315:Fetal Diseases / Q000097:blood* / Q000175:diagnosis; D005319:Fetal Hemoglobin / Q000032:analysis; D006801:Humans; D008163:Luminescent Measurements; D009000:Monocytes; D011247:Pregnancy; D011379:Prognosis; D012203:Rh Isoimmunization / Q000276:immunology*
D005319:Fetal Hemoglobin