title: Selenium depletion in patients on home parenteral nutrition. The effect of selenium supplementation.
abstract: Severe selenium (Se) depletion was found in nine patients receiving long-term home parenteral nutrition because of short bowel syndrome. Plasma Se ranged from 0-0.51 (median 0.21 mumol/L), and erythrocyte Se ranged from 0.7-2.6 (median 1.8 mumol/gHgb), which was significantly lower than in the controls. Glutathione peroxidase (GSHPx) in plasma and erythrocytes was also decreased. After bolus injections with 200 micrograms Se/d in the form of sodium selenite for 4 mo, followed by 100 micrograms/d for 8 mo, plasma Se increased to values slightly but significantly higher than in the controls. Erythrocyte Se reached normal levels in most of the patients after 4 mo substitution, but it remained lower than in the controls. Following Se supplementation, plasma and erythrocyte GSHPx did not differ between patients and controls. These data suggest that all patients receiving long-term parenteral nutrition because of short bowel syndrome should receive at least 100 micrograms sodium selenite/d when given as bolus injections to avoid Se depletion.
authors.affiliation: Medical Department A, Rigshospitalet, Denmark.
authors.forename: T
authors.initials: T
authors.lastname: Rannem
authors.forename: K
authors.initials: K
authors.lastname: Ladefoged
authors.forename: E
authors.initials: E
authors.lastname: Hylander
authors.forename: J
authors.initials: J
authors.lastname: Hegnhøj
authors.forename: S
authors.initials: S
authors.lastname: Jarnum
mesh_terms: D000328:Adult; D004912:Erythrocytes / Q000378:metabolism; D005260:Female; D005979:Glutathione Peroxidase / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D016331:Parenteral Nutrition, Home / Q000009:adverse effects*; D012643:Selenium / Q000008:administration & dosage / Q000097:blood / Q000172:deficiency*
chemical_list: D005979:Glutathione Peroxidase; D012643:Selenium