A variant mRNA species encoding a truncated form of Fas antigen in the rat liver.
A variant form of the Fas antigen cDNA was isolated from the rat liver. The cDNA contains an insertion sequence of 25 nucleotide residues and codes for a protein consisting of 65 amino acids representing a signal peptide and an N-terminal portion of the extracytoplasmic domain of Fas antigen. The expression of a variant mRNA species is less abundant in the liver compared with that of an ordinary mRNA species. The variant mRNA, though its function is unknown, is plausibly produced by an alternative splicing.
Kimura
K
K
Department of Biochemistry, National Defense Medical College, Saitama, Japan.
Wakatsuki
T
T
Yamamoto
M
M
D000595:Amino Acid Sequence; D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D001483:Base Sequence; D015152:Blotting, Northern; D014644:Genetic Variation; D008099:Liver / Q000276:immunology; D008565:Membrane Proteins / Q000235:genetics*; D008969:Molecular Sequence Data; D011061:Poly A / Q000235:genetics; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000235:genetics*; D051381:Rats; D017422:Sequence Analysis, DNA; D017384:Sequence Deletion; D017386:Sequence Homology, Amino Acid; D012995:Solubility; D013950:Thymus Gland / Q000276:immunology; D019014:fas Receptor
D000954:Antigens, Surface; D008565:Membrane Proteins; D012333:RNA, Messenger; D019014:fas Receptor; D011061:Poly A