title: The inner-core, outer-core and capsule cells of the human Pacinian corpuscles: an immunohistochemical study.
abstract: The distribution of several markers for Schwann cells and perineurial cells, including S-100 protein, Leu-7 antigen, vimentin and epithelial membrane antigen was studied immunohistochemically in Pacinian corpuscles from human digital skin. Formaldehyde fixed paraffin embedded tissues, and monoclonal antibodies were used. A positive immunostaining for S-100 protein, Leu-7 antigen and vimentin was found in the inner-core cells, whereas the outer-core and capsule lamellae were labelled for both epithelial membrane antigen and vimentin. The pattern of vimentin immunoreactivity was not homogeneous but focally distributed, and occasionally, positive immunoreactivity for vimentin was observed in blood vessels supplying the capsule. Present results provide evidence that some antibodies against Schwann cells and perineurial fibroblastic cells, selectively stain the Pacinian corpuscles derivatives while others are commonly expressed for non-neuronal cells of sensory nerve corpuscles.
authors.affiliation: Departamento de Morfología y Biología Celular, Universidad de Oviedo, Spain.
authors.forename: J A
authors.initials: JA
authors.lastname: Vega
authors.forename: M E
authors.initials: ME
authors.lastname: Del Valle
authors.forename: J J
authors.initials: JJ
authors.lastname: Haro
authors.forename: F J
authors.initials: FJ
authors.lastname: Naves
authors.forename: B
authors.initials: B
authors.lastname: Calzada
authors.forename: R
authors.initials: R
authors.lastname: Uribelarrea
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal; D015703:Antigens, CD / Q000032:analysis; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D015415:Biomarkers; D018959:CD57 Antigens; D002648:Child; D006801:Humans; D007124:Immunoenzyme Techniques; D008562:Membrane Glycoproteins / Q000032:analysis; D008875:Middle Aged; D018396:Mucin-1; D009077:Mucins / Q000032:analysis; D009419:Nerve Tissue Proteins / Q000032:analysis; D010141:Pacinian Corpuscles / Q000737:chemistry / Q000166:cytology*; D009418:S100 Proteins / Q000032:analysis; D012583:Schwann Cells / Q000648:ultrastructure; D014746:Vimentin / Q000032:analysis
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D015415:Biomarkers; D018959:CD57 Antigens; D008562:Membrane Glycoproteins; D018396:Mucin-1; D009077:Mucins; D009419:Nerve Tissue Proteins; D009418:S100 Proteins; D014746:Vimentin