Induction of chromosome aberrations by pyrimethamine in cultured Chinese hamster (CHL) cells.
Induction of chromosome aberrations was investigated in cultured Chinese hamster cells treated with pyrimethamine. Pyrimethamine without metabolic activation strongly induced structural chromosome aberrations in a dose-dependent manner. Aberrant metaphase cells occurred at a frequency of 80%, when cells were treated at 1.6 microgram/ml for 48 h.
Ono
T
T
National Veterinary Assay Laboratory, Tokyo, Japan.
Norimatsu
M
M
Yoshimura
H
H
D000818:Animals; D002460:Cell Line; D002869:Chromosome Aberrations; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D005260:Female; D008168:Lung / Q000166:cytology; D008938:Mitosis / Q000187:drug effects; D009153:Mutagens / Q000633:toxicity*; D011739:Pyrimethamine / Q000633:toxicity*
D009153:Mutagens; D011739:Pyrimethamine