Peripheral blood stem cell mobilization using high-dose cyclophosphamide and G-CSF in pretreated patients with lymphoma.
Peripheral blood stem cell (PBSC) mobilization for autologous transplantation is more difficult in treated patients and those with bone marrow involvement. In 17 pretreated lymphoma patients, cyclophosphamide (4 g/m2) and G-CSF mobilized a median circulating peak of 1959 CFU-GM/ml on day 12.5. PBSC harvesting commenced when WBC was 1 x 10(9)/l at day 10.5 collected a median of 21.2 x 10(4)/CFU-GM/kg. 13/17 (76%) patients exceeded the 10 x 10(4) CFU-GM/kg threshold for engraftment. The CFU-GM yield was significantly higher in patients whose WBC recovered from 1-5 x 10(9)/l in less than 3 days and correlated with the maximum WBC pre and post the cyclophosphamide induced nadir. This regime safely mobilized adequate PBSC in the majority of pretreated lymphoma patients.
Craig
J I
JI
Department of Haematology, Royal Infirmary of Edinburgh, Scotland.
Anthony
R S
RS
Stewart
A
A
Thomson
E B
EB
Gillon
J
J
Parker
A C
AC
D000328:Adult; D003520:Cyclophosphamide / Q000494:pharmacology*; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects* / Q000378:metabolism*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008223:Lymphoma / Q000097:blood* / Q000628:therapy; D008875:Middle Aged; D010976:Platelet Count / Q000187:drug effects
D016179:Granulocyte Colony-Stimulating Factor; D003520:Cyclophosphamide