[The anti-arrhythmia effect of Rhodiola rosea and its possible mechanism].
A course injection of Rhodiola rosea extract for eight days was reported to increase the resistance of experimental animals to adrenalin- or CaCl2-induced arrhythmias. Preliminary injection of naloxone in a dose of 0.5 mg/kg eliminated the antiarrhythmic effect of Rhodiola. Indomethacin had no effect the antiarrhythmic action of Rhodiola. The antiarrhythmic effect of Rhodiola course injections was assumed to be associated with the induction of opioid peptides biosynthesis.
Lishmanov
Iu B
IuB
Maslova
L V
LV
Maslov
L N
LN
Dan'shina
E N
EN
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002122:Calcium Chloride; D005117:Cardiac Complexes, Premature / Q000139:chemically induced / Q000188:drug therapy; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009270:Naloxone / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D014693:Ventricular Fibrillation / Q000139:chemically induced / Q000188:drug therapy
D000889:Anti-Arrhythmia Agents; D010936:Plant Extracts; D009270:Naloxone; D002122:Calcium Chloride; D007213:Indomethacin; D004837:Epinephrine