title: Striking similarities between HIV-1 Env protein and the apoptosis mediating cell surface antigen Fas. Role in the pathogenesis of AIDS.
abstract: We have designed a computer strategy in order to detect systematically peptidic sites with the potential of interfering with the immune regulatory processes. Applying this software to HIV-1 proteins has led us to unravel a few peptidic sites which could either act directly or be the targets of an auto-immune reaction during HIV-1 infection. We previously reported that the SLWDQ pentapeptide identity with a critical site of CD4 could trigger in HIV-1 infected individuals both an humoral and a cellular autoimmune reaction. In this study, we focused on surprising similitudes unravelled by our software Automat, between HIV-1/2 and another immunoregulatory molecule, the Fas protein which is also called the apoptosis-mediating cell-surface antigen.
authors.affiliation: Laboratoire de Physiopathologie Cellulaire, Université P & M Curie, Paris, France.
authors.forename: J F
authors.initials: JF
authors.lastname: Zagury
authors.forename: H
authors.initials: H
authors.lastname: Cantalloube
authors.forename: A
authors.initials: A
authors.lastname: Achour
authors.forename: Y Y
authors.initials: YY
authors.lastname: Cho
authors.forename: L
authors.initials: L
authors.lastname: Fall
authors.forename: A
authors.initials: A
authors.lastname: Lachgar
authors.forename: V
authors.initials: V
authors.lastname: Chams
authors.forename: A
authors.initials: A
authors.lastname: Astgen
authors.forename: D
authors.initials: D
authors.lastname: Biou
authors.forename: O
authors.initials: O
authors.lastname: Picard
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000378:metabolism; D000954:Antigens, Surface / Q000737:chemistry*; D015704:CD4 Antigens / Q000737:chemistry / Q000276:immunology; D015699:HIV Envelope Protein gp120 / Q000737:chemistry* / Q000276:immunology; D015497:HIV-1; D066298:In Vitro Techniques; D017386:Sequence Homology, Amino Acid; D012984:Software; D019014:fas Receptor
chemical_list: D000954:Antigens, Surface; D015704:CD4 Antigens; D015699:HIV Envelope Protein gp120; D019014:fas Receptor