A comparison of the effects of sodium saccharin in NBR rats and in intact and castrated male F344 rats.
High doses of sodium saccharin (NaSac) increase proliferation in the bladder of the rat, with a male preponderance. The possibility that alpha 2u-globulin is involved in its mechanism of action was evaluated by feeding it at 7.5% of the diet to NCI-Black-Reiter (NBR) male rats, which do not synthesize liver-derived alpha 2u-globulin. NaSac affected urinary parameters similarly in F344 and NBR male rats, but NBR rats consumed more water leading to greater urinary volume. NaSac produced less proliferation in NBR than in intact F344 rats, with intermediate changes in castrated F344 males, which had intermediate urinary alpha 2u-globulin levels.
Garland
E M
EM
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-3135.
St John
M
M
Asamoto
M
M
Eklund
S H
SH
Mattson
B J
BJ
Johnson
L S
LS
Cano
M
M
Cohen
S M
SM
D000510:Alpha-Globulins / Q000652:urine; D000818:Animals; D002432:Cecum / Q000033:anatomy & histology; D007668:Kidney / Q000033:anatomy & histology; D008099:Liver / Q000033:anatomy & histology; D008297:Male; D009919:Orchiectomy; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344; D012439:Saccharin / Q000494:pharmacology*
D000510:Alpha-Globulins; C013803:alpha 2u globulin; D012439:Saccharin