title: [Modeling antigenic determinants of the hepatitis A virus using synthetic peptides].
abstract: Monoclonal and polyclonal anti-hepatitis A (HAV) antibodies were used to search for peptides mimicking the antigenic determinants of HAV. Synthetic peptides VP1 115-139, VP1 117-139, VP1 126-139, VP2 69-99, VP2 80-99, VP3 45-57, VP3 137-150, were shown to bind the anti-HAV antibodies in ELISA. Peptides VP1 115-139, VP1 117-139, VP2 69-99 were utilized to produce the antipeptide antibodies. Mice were immunized with the free peptides or with their conjugates with ovalbumin. Only the free VP2 69-99 caused formation of HAV binding antibodies.
authors.forename: L N
authors.initials: LN
authors.lastname: Kulik
authors.forename: V S
authors.initials: VS
authors.lastname: Ivanov
authors.forename: L D
authors.initials: LD
authors.lastname: Chikin
authors.forename: N P
authors.initials: NP
authors.lastname: Berkova
authors.forename: A T
authors.initials: AT
authors.lastname: Kozhich
authors.forename: A E
authors.initials: AE
authors.lastname: Gabriélian
authors.forename: V T
authors.initials: VT
authors.lastname: Ivanova
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes / Q000737:chemistry*; D006507:Hepatovirus / Q000276:immunology*; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010455:Peptides / Q000737:chemistry*
chemical_list: D000911:Antibodies, Monoclonal; D000939:Epitopes; D010455:Peptides