Prolongation of action of local anaesthetic by a possible complexation: clinical trials.
Long lasting pain relief for patients of malignancy involving head, neck, face and patients of trigeminal neuralgia was sought by the use of lignocaine with addition of complexing agents. Five patients with severe intractable pain of malignancy involving the trigeminal (V cranial) nerve mainly the maxillary and mandibular divisions, two patients of trigeminal neuralgia with trigger zone in maxillary division were treated. Remarkable prolongation of action of pain relief up to 6 weeks could be achieved. The recurred pain was also of less severity especially radiation was less. An explanation of the possible mechanism is offered.
Desai
K P
KP
Department of Chemistry, Shivaji University, Kolhapur.
Desai
P M
PM
D000328:Adult; D000779:Anesthetics, Local / Q000627:therapeutic use*; D004357:Drug Synergism; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications; D006801:Humans; D008297:Male; D008875:Middle Aged; D009407:Nerve Block; D010166:Palliative Care / Q000379:methods*; D014277:Trigeminal Neuralgia / Q000209:etiology / Q000628:therapy*
D000779:Anesthetics, Local