The role of cytokines in the generation of skin lesions in dermatitis herpetiformis.
The infiltration of polymorphonuclear neutrophils (PMN) into the upper dermis which characterizes the skin lesions of dermatitis herpetiformis (DH) has never been satisfactorily explained. This study has shown that lesional skin of patients with DH has increased expression of endothelial leucocyte adhesion molecules (ELAM) in the deep dermis, combined with a markedly increased staining for interleukin 8 (IL-8) in the basal epidermal layer. Dendritic cells which stained for granulocyte macrophage colony stimulating factor (GM-CSF) were also observed at the dermo-epidermal junction, and this phenomenon was more pronounced in lesional than in uninvolved DH skin. ELAM, IL-8 and GM-CSF are known to promote infiltration and activation of PMN, and it is suggested that these cytokines may play a key role in the generation of DH lesions.
Graeber
M
M
Department of Dermatology, St Mary's Hospital, London, U.K.
Baker
B S
BS
Garioch
J J
JJ
Valdimarsson
H
H
Leonard
J N
JN
Fry
L
L
D000328:Adult; D015815:Cell Adhesion Molecules / Q000032:analysis; D016207:Cytokines / Q000276:immunology*; D003874:Dermatitis Herpetiformis / Q000276:immunology*; D019040:E-Selectin; D004817:Epidermis / Q000276:immunology; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D016209:Interleukin-8 / Q000032:analysis; D015603:Keratinocytes / Q000276:immunology; D009504:Neutrophils / Q000276:immunology; D012867:Skin / Q000276:immunology*
D015815:Cell Adhesion Molecules; D016207:Cytokines; D019040:E-Selectin; D016209:Interleukin-8; D016178:Granulocyte-Macrophage Colony-Stimulating Factor