title: A study of tachykinin-immunoreactivity in the cat visual cortex.
abstract: The localization of tachykinin-immunoreactivity in the cat visual cortex (area 17) was investigated using immunohistochemical methods. Strong laminar specificity was observed, with immunoreactivity highest in layer V, followed by layers I, VI, II and III, and the lowest density in layer IV. Most of the immunoreactive product was localized in neuronal processes. A few immunopositive cell bodies were also present. The immunopositive neurons were non-pyramidal, multipolar, or bipolar in shape, and mostly found in layer V. There were particularly dense immunopositive fibers and varicosities around somata in layer V. These may represent tachykinin-containing presynaptic terminals (boutons). The results provide anatomical evidence that tachykinins may primarily affect layer V neurons in the cat visual cortex.
authors.affiliation: Department of Ophthalmology, University of British Columbia, Vancouver, Canada.
authors.forename: Q
authors.initials: Q
authors.lastname: Gu
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: M S
authors.initials: MS
authors.lastname: Cynader
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002415:Cats; D007150:Immunohistochemistry; D015288:Neurokinin A / Q000276:immunology / Q000378:metabolism; D015287:Neurokinin B / Q000276:immunology / Q000378:metabolism; D009474:Neurons / Q000502:physiology; D017729:Presynaptic Terminals / Q000378:metabolism; D013373:Substance P / Q000276:immunology / Q000378:metabolism; D015320:Tachykinins / Q000276:immunology / Q000378:metabolism*; D014793:Visual Cortex / Q000033:anatomy & histology* / Q000502:physiology / Q000648:ultrastructure
chemical_list: D000911:Antibodies, Monoclonal; D015320:Tachykinins; D013373:Substance P; D015288:Neurokinin A; D015287:Neurokinin B