title: Galantide stimulates sexual behaviour in male rats.
abstract: While intracerebroventricular injection of galanin (5 micrograms/rat) inhibited sexual behavior in experienced male rats--without producing any other locomotor or behavioral deficit-, injection of the galanin antagonist, galantide, by the same route (1 or 2 micrograms/rat) stimulated sexual behavior (improving arousal, motivation and performance indexes) and antagonized the effect of galanin. These data further suggest that galanin plays a physiological role in male sexual behavior.
authors.affiliation: Department of Biomedical Sciences, University of Modena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Benelli
authors.forename: R
authors.initials: R
authors.lastname: Arletti
authors.forename: A
authors.initials: A
authors.lastname: Bertolini
authors.forename: B
authors.initials: B
authors.lastname: Menozzi
authors.forename: R
authors.initials: R
authors.lastname: Basaglia
authors.forename: R
authors.initials: R
authors.lastname: Poggioli
mesh_terms: D000818:Animals; D005260:Female; D019004:Galanin / Q000031:analogs & derivatives; D007276:Injections, Intraventricular; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D009479:Neuropeptides / Q000008:administration & dosage / Q000494:pharmacology; D010052:Ovariectomy; D010455:Peptides / Q000008:administration & dosage / Q000037:antagonists & inhibitors* / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012726:Sexual Behavior, Animal / Q000187:drug effects*; D013373:Substance P / Q000031:analogs & derivatives*
chemical_list: D009479:Neuropeptides; D010455:Peptides; C074975:galantide; D013373:Substance P; D019004:Galanin