title: Altered angiotensin-II receptors in human hepatocellular and hepatic metastatic colon cancers.
abstract: OBJECTIVE
  To characterize angiotensin-II receptor density and affinity in normal and cirrhotic livers and in hepatocellular and metastatic colorectal cancer.
  
  
  BACKGROUND
  Several studies have indicated a possible beneficial effect of angiotensin-II as a biologic response modifier in the treatment of hepatic or metastatic colon cancer. This is based on evidence that angiotensin-II will cause a selective increase in arterial vasoconstriction in normal liver compared with tumor.
  
  
  METHODS
  Human hepatoma (5), metastatic colon (10), or cirrhotic (3) liver was obtained. Non-tumor-bearing regions served as normal liver. Angiotensin-II receptor binding was determined on membranes with 125I-angiotensin-II and in situ studies were performed using the biotin-avidin detection system.
  
  
  RESULTS
  Angiotensin-II receptor density was markedly down-regulated in tumor compared with normal or cirrhotic liver.
  
  
  CONCLUSIONS
  A loss of angiotensin-II receptors occurs on the neovasculature of hepatic tumors.
authors.affiliation: Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, Maryland.
authors.forename: J V
authors.initials: JV
authors.lastname: Sitzmann
authors.forename: Y
authors.initials: Y
authors.lastname: Wu
authors.forename: J L
authors.initials: JL
authors.lastname: Cameron
mesh_terms: D000328:Adult; D000368:Aged; D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000098:blood supply / Q000378:metabolism* / Q000556:secondary*; D015179:Colorectal Neoplasms / Q000378:metabolism* / Q000556:secondary*; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D008099:Liver / Q000378:metabolism; D008103:Liver Cirrhosis / Q000378:metabolism; D008113:Liver Neoplasms / Q000098:blood supply / Q000378:metabolism* / Q000556:secondary*; D008114:Liver Neoplasms, Experimental / Q000098:blood supply / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009389:Neovascularization, Pathologic / Q000378:metabolism; D051381:Rats; D011945:Receptors, Angiotensin / Q000378:metabolism*
chemical_list: D011945:Receptors, Angiotensin