title: Predicting the severity of rhesus alloimmunization: monocyte-mediated chemiluminescence versus maternal anti-D antibody estimation.
abstract: Anti-D haemolytic antibody concentration and chemiluminescence (CLT) opsonic index was measured in maternal blood obtained from 20 alloimmunized pregnancies at 17-28 weeks undergoing intrauterine fetal blood sampling for the estimation of fetal haemoglobin concentration. The fetal haemoglobin concentration was significantly associated with the maternal serum CLT opsonic index (r = -0.566, P < 0.01) but not with the maternal anti-D concentration (r = -0.329). The data of this study indicate that measurement of maternal serum CLT opsonic index may be more accurate than anti-D quantification in providing non-invasive prediction of the degree of fetal anaemia.
authors.affiliation: Department of Haematology, Kings College Hospital Medical School, London.
authors.forename: A G
authors.initials: AG
authors.lastname: Buggins
authors.forename: B
authors.initials: B
authors.lastname: Thilaganathan
authors.forename: H
authors.initials: H
authors.lastname: Hambley
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D000740:Anemia / Q000097:blood* / Q000175:diagnosis; D005260:Female; D005315:Fetal Diseases / Q000097:blood* / Q000175:diagnosis; D005319:Fetal Hemoglobin / Q000032:analysis; D006801:Humans; D008163:Luminescent Measurements; D009000:Monocytes; D011247:Pregnancy; D011379:Prognosis; D012203:Rh Isoimmunization / Q000276:immunology*
chemical_list: D005319:Fetal Hemoglobin