Replacement of L-Lys by D-Lys(NH2) in peptide Ala-Arg-Pro-Ala-Lys (peptide 6A) increases its coronary blood flow-promoting properties.
Peptide 6A, a degradation of B beta chain of fibrinogen, is known to increase coronary and femoral blood flow. In this study, we examined the effects of peptide 32, an analogue of peptide 6A on coronary blood flow in anesthetized dogs. Intracoronary administration of equimolar amounts of peptide 32 and peptide 6A showed a greater (p < 0.05) increase in blood flow with peptide 32. Intravenous administration of peptide 32 also resulted in greater and longer-lasting increase in coronary blood flow. The greater blood flow enhancing effect of peptide 32 than that of peptide 6A may relate to absence of its degradation by angiotensin converting enzyme.
Saldeen
T G
TG
Department of Forensic Medicine, Uppsala University, Sweden.
Nichols
W W
WW
Saldeen
K
K
Wallin
R
R
Mehta
J L
JL
D000595:Amino Acid Sequence; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D004285:Dogs; D015773:Enalaprilat / Q000494:pharmacology; D005338:Fibrin Fibrinogen Degradation Products / Q000737:chemistry / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects; D008239:Lysine / Q000737:chemistry / Q000378:metabolism; D008407:Mast Cells / Q000378:metabolism; D008969:Molecular Sequence Data; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism; D051381:Rats; D014655:Vascular Resistance / Q000187:drug effects*
D005338:Fibrin Fibrinogen Degradation Products; C026893:fibrinogen peptide 6A; C086496:peptide 32; D007703:Peptidyl-Dipeptidase A; D015773:Enalaprilat; D008239:Lysine