title: Nimesulide in the treatment of menstrual migraine.
abstract: In a controlled double-blind clinical trial, 30 patients aged 18 to 45 years, with menstrual migraine, were randomly assigned to 2 parallel treatment groups of 15 patients each. One group received granular nimesulide 100mg 3 times daily and the other group received placebo. Each treatment was given for 10 days, starting from the onset of migraine symptoms, and was repeated for the 2 following menstrual cycles. The overall assessment of efficacy in the 2 groups was based on hourly self-evaluation of pain during each study day. In patients treated with nimesulide, pain intensity and duration were significantly reduced compared with placebo (p = 0.0001) during all the menstrual cycles in the study.
authors.affiliation: Centro Cefalee VI Clinica Medica, Università La Sapienza, Rome, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Giacovazzo
authors.forename: M F
authors.initials: MF
authors.lastname: Gallo
authors.forename: V
authors.initials: V
authors.lastname: Guidi
authors.forename: R
authors.initials: R
authors.lastname: Rico
authors.forename: I
authors.initials: I
authors.lastname: Scaricabarozzi
mesh_terms: D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008599:Menstruation Disturbances / Q000188:drug therapy*; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D013449:Sulfonamides / Q000627:therapeutic use*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; C012655:nimesulide