Trolox attenuates cortical neuronal injury induced by iron, ultraviolet light, glucose deprivation, or AMPA.
The vitamin E analog, trolox, protected cultured cortical neurons against damage induced by exposure to either iron ions or ultraviolet (UV) light, consistent with an ability to inhibit free radical-mediated cytotoxicity. Trolox also reduced neuronal death induced by 24 h exposure to alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid (AMPA), but not that induced by N-methyl-D-aspartate (NMDA). When combined with the NMDA receptor antagonist dextrorphan, trolox also reduced the neuronal injury induced by glucose deprivation.
Chow
H S
HS
Department of Neurology and Neurological Sciences, Stanford University, CA 94305.
Lynch
J J
JJ
Rose
K
K
Choi
D W
DW
D000818:Animals; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000187:drug effects / Q000473:pathology* / Q000528:radiation effects; D002839:Chromans / Q000494:pharmacology*; D003917:Dextrorphan / Q000494:pharmacology; D004338:Drug Combinations; D005947:Glucose / Q000172:deficiency*; D007501:Iron / Q000494:pharmacology*; D051379:Mice; D009457:Neuroglia / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D009474:Neurons / Q000187:drug effects / Q000473:pathology / Q000528:radiation effects; D014466:Ultraviolet Rays; D014810:Vitamin E / Q000031:analogs & derivatives; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology*
D002839:Chromans; D004338:Drug Combinations; D003917:Dextrorphan; D014810:Vitamin E; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D007501:Iron; D005947:Glucose; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid