title: Acrolein genotoxicity in Drosophila melanogaster. II. Influence of mus201 and mus308 mutations.
abstract: The influence of mus201 and mus308 mutants on acrolein mutagenicity was analyzed with the Drosophila melanogaster sex-linked recessive lethal test (SLRL), using the maternal approach, to further study the mechanisms of action of this chemical. The hypermutability indices obtained were 2.59 for mus201 and 0.52 for mus308 conditions. Statistical analysis indicates that whereas part of the acrolein-induced lesions are repaired by excision mechanism, as expected for a cyclic agent, there is no demonstrable influence of the mus308 locus on the mutagenicity of this chemical.
authors.affiliation: Departamento de Biología Funcional, Universidad de Oviedo, Spain.
authors.forename: A R
authors.initials: AR
authors.lastname: Barros
authors.forename: M A
authors.initials: MA
authors.lastname: Comendador
authors.forename: L M
authors.initials: LM
authors.lastname: Sierra
mesh_terms: D000171:Acrolein / Q000633:toxicity*; D000818:Animals; D002874:Chromosome Mapping; D004260:DNA Repair; D004331:Drosophila melanogaster / Q000187:drug effects* / Q000235:genetics; D005260:Female; D008297:Male; D009154:Mutation
chemical_list: D000171:Acrolein