Concentration of serum amyloid P component in the CSF as a possible marker of cerebral amyloid deposits in Alzheimer's disease.
Serum amyloid P component (SAP) is a normal plasma protein produced in the liver and co-deposited with amyloid fibrils in all types of amyloidosis, including cerebral beta-protein amyloid deposits associated with Alzheimer's disease (AD). We have measured its concentration and those of alpha 2-macroglobulin, IgG and albumin in the CSF of 51 patients with AD and 50 healthy and disease control subjects. The mean levels of SAP were 12.8 ng/ml in AD and 8.5 ng/ml in controls (P < 0.0125); there was no difference in the levels of the other proteins studied. The observed concentrations of SAP were much lower than expected for a protein of molecular weight 254620. The difference between AD and controls suggests that the concentration of SAP in the CSF may be affected by the presence of cerebral amyloidosis.
Hawkins
P N
PN
Immunological Medicine Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Rossor
M N
MN
Gallimore
J R
JR
Miller
B
B
Moore
E G
EG
Pepys
M B
MB
D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid* / Q000378:metabolism; D000682:Amyloid / Q000378:metabolism*; D015415:Biomarkers / Q000134:cerebrospinal fluid; D001921:Brain / Q000378:metabolism*; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D001523:Mental Disorders / Q000134:cerebrospinal fluid; D012016:Reference Values; D012709:Serum Albumin / Q000134:cerebrospinal fluid; D000683:Serum Amyloid P-Component / Q000134:cerebrospinal fluid*; D000511:alpha-Macroglobulins / Q000134:cerebrospinal fluid
D000682:Amyloid; D015415:Biomarkers; D007074:Immunoglobulin G; D012709:Serum Albumin; D000683:Serum Amyloid P-Component; D000511:alpha-Macroglobulins