Dermal toxicity of hexachlorocyclohexane and pirimiphos-methyl in female rats.
Technical hexachlorocyclohexane (100 mg/kg/d) and pirimiphosmethyl EC 50 (250 mg/kg/d) given individually and in combination to female rats for 7, 15 or 30 d by skin application caused poisoning, pathomorphological changes in vital organs, and significant enzymatic changes in liver and serum. The changes produced by the 2 compounds in combination did not suggest potentiation at the tested dose levels.
Raizada
R B
RB
Pesticide Toxicology Laboratory, Industrial Toxicology Research Centre, Lucknow, India.
Srivastava
M K
MK
Kaushal
R A
RA
Singh
R P
RP
Gupta
K P
KP
Dikshith
T S
TS
D000279:Administration, Cutaneous; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D001556:Hexachlorocyclohexane / Q000008:administration & dosage / Q000633:toxicity*; D007306:Insecticides / Q000008:administration & dosage / Q000633:toxicity*; D008099:Liver / Q000187:drug effects; D009929:Organ Size / Q000187:drug effects; D009946:Organothiophosphorus Compounds / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000187:drug effects
D007306:Insecticides; D009946:Organothiophosphorus Compounds; C014153:pirimiphos methyl; D001556:Hexachlorocyclohexane