[The effect of glucocorticoid hormones on the blood pressure and contractile activity of the mesenteric arteries in rats].
Methylprednisolone (MP) induced first a decrease and then an increase of the blood pressure in Wistar rats. The hypertensive effect stabilised after three administrations. The contractile response amplitude in electric stimulation of the vascular-motor nerves first increased and then sharply dropped. The glycocorticoids were concluded to reduce the contractile properties of vessels simultaneously increasing the blood pressure.
Il'ina
N M
NM
Didenko
A V
AV
Iazykov
V V
VV
Shaliapina
V G
VG
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D007274:Injections, Intraperitoneal; D007275:Injections, Intravenous; D008297:Male; D008638:Mesenteric Arteries / Q000187:drug effects / Q000502:physiology; D008775:Methylprednisolone / Q000008:administration & dosage / Q000494:pharmacology*; D009119:Muscle Contraction / Q000187:drug effects*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D008775:Methylprednisolone