title: Potent inhibitors of histamine release: polyhydroxylated sterols from the Okinawan soft coral Sinularia abrupta.
abstract: A new polyhydroxylated steroid (24-methylene-1 alpha, 3 beta, 11 alpha-trihydroxycholest-5-ene-18-oic acid-3-acetate, 1) and known related compounds (2-4) from the soft coral Sinularia abrupta have potently inhibited histamine release from rat peritoneal mast cells induced by anti-immunoglobulin E. The inhibitory effect of 1 was approximately 6500 times stronger than that of disodium cromoglycate, a well-known antiallergic drug.
authors.affiliation: Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Shoji
authors.forename: A
authors.initials: A
authors.lastname: Umeyama
authors.forename: M
authors.initials: M
authors.lastname: Takei
authors.forename: S
authors.initials: S
authors.lastname: Arihara
mesh_terms: D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000494:pharmacology; D002782:Cholestenes / Q000302:isolation & purification / Q000494:pharmacology; D003063:Cnidaria / Q000737:chemistry*; D006633:Histamine Antagonists / Q000302:isolation & purification / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006900:Hydroxylation; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013261:Sterols / Q000302:isolation & purification* / Q000494:pharmacology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D002782:Cholestenes; D006633:Histamine Antagonists; D013261:Sterols; C026408:anti-IgE antibodies; C089098:sinulabosterol