[Protein S deficiency, acute phase reaction and thrombosis].
Protein S deficiency increases risk of thrombosis. At present, we have information on 63 Norwegian individuals with hereditary protein S deficiency belonging to 25 different families. 42 of the individuals have experienced at least one thromboembolic episode, and seven a cerebral infarction before the age of 70 years. The amount of free protein S in plasma is dependent on variation of the acute phase protein C4b-binding protein (C4bBP). Acute phase response with increased C4bBP induces free protein S deficiency, and increases risk of thrombosis. In patients with protein S deficiency, warfarin may reduce free protein S to critically low levels, and thus explain why, in some patients, recurrent thrombosis occurs during warfarin treatment. In this situation, warfarin should be replaced by heparin.
Odegaard
O R
OR
Sentrallaboratoriet, Aker sykehus, Oslo.
Try
K
K
Ly
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B
Gundersen
T
T
Linnebo
S
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D000209:Acute-Phase Proteins / Q000276:immunology* / Q000378:metabolism; D000328:Adult; D000368:Aged; D002352:Carrier Proteins / Q000276:immunology; D005260:Female; D006801:Humans; D016167:Integrin alphaXbeta2; D008297:Male; D008875:Middle Aged; D009664:Norway; D017293:Protein S / Q000235:genetics; D018455:Protein S Deficiency; D012307:Risk Factors; D013923:Thromboembolism / Q000097:blood / Q000209:etiology / Q000235:genetics; D013924:Thrombophlebitis / Q000097:blood / Q000209:etiology / Q000235:genetics; D013927:Thrombosis / Q000097:blood / Q000209:etiology* / Q000235:genetics
D000209:Acute-Phase Proteins; D002352:Carrier Proteins; D016167:Integrin alphaXbeta2; D017293:Protein S