title: Carcinogenicity of dietary dimethylnitrosomorpholine, N-methyl-N'-nitro-N-nitrosoguanidine, and dibromoethane in rainbow trout.
abstract: Eighteen-mo feeding trials of rainbow trout were used to test the carcinogenicity of 5 chemicals in this species. A single exposure level was used for each substance. The doses and chemicals tested were 1,556 ppm 2,6-dimethylnitrosomorpholine (DMNM), 500 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), 2,000 ppm 1,2-dibromoethane (DBE), 2,000 ppm 1,1-dichloroethylene (DCE), and 200 ppm cyclophosphamide (CP). Liver and/or glandular stomach neoplasms were produced by DMNM (liver and stomach), MNNG (stomach), and DBE (chiefly, stomach tumors). In addition, DMNM produced a low incidence of swimbladder papillomas and caused testicular atrophy in 50% of treated males. DCE and CP produced no neoplasms at the exposure levels used. No evidence of other chronic toxicity was seen for any of the 5 compounds.
authors.affiliation: Marine/Freshwater Biomedical Sciences Center, Oregon State University, Corvallis 97331, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Hendricks
authors.forename: D W
authors.initials: DW
authors.lastname: Shelton
authors.forename: P M
authors.initials: PM
authors.lastname: Loveland
authors.forename: C B
authors.initials: CB
authors.lastname: Pereira
authors.forename: G S
authors.initials: GS
authors.lastname: Bailey
mesh_terms: D000821:Animal Feed; D000818:Animals; D002273:Carcinogens; D003520:Cyclophosphamide / Q000633:toxicity; D004000:Dichloroethylenes / Q000633:toxicity; D015946:Ethylene Dibromide / Q000633:toxicity*; D005260:Female; D008297:Male; D008769:Methylnitronitrosoguanidine / Q000633:toxicity*; D009602:Nitrosamines / Q000633:toxicity*; D017686:Oncorhynchus mykiss; D012727:Sex Characteristics
chemical_list: D002273:Carcinogens; D004000:Dichloroethylenes; D009602:Nitrosamines; D008769:Methylnitronitrosoguanidine; C014130:N-nitroso-2,6-dimethylmorpholine; D015946:Ethylene Dibromide; C029297:vinylidene chloride; D003520:Cyclophosphamide