Iloprost attenuates trauma-related pulmonary sequestration of leucocytes and platelets.
The purpose of this study was to investigate the effects of iloprost, a synthetic prostacyclin analogue, on the pulmonary cellular trapping after a standardized soft tissue trauma. In two groups 1 and 2 iloprost was given in doses of 100 ng/kg/min commencing 30 and 20 min respectively prior to trauma and ceasing 10 min after trauma. 111Indium-oxine was used to label neutrophils in 6 animals from each group. Platelets were labelled in 6 and 7 animals respectively. A third group of 11 pigs served as a control and did not receive iloprost. The pulmonary sequestration of platelets and neutrophils was studied dynamically with a gamma camera and directly after trauma was significantly less in group 1 when compared to the control group. A rise in pulmonary vascular resistance and pulmonary arterial pressure was seen in the control group immediately after trauma but this was not evident in the iloprost groups. PaO2 decreased significantly in group 1 and 2 during the iloprost infusion. The results indicate that iloprost attenuates the pulmonary cellular sequestration and changes in central hemodynamics during trauma in this model.
Malmros
C
C
Department of Anesthesiology, University Hospital, Lund, Sweden.
Blomquist
S
S
Mårtensson
L
L
Thörne
J
J
D000818:Animals; D001792:Blood Platelets / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects; D016285:Iloprost / Q000494:pharmacology*; D007205:Indium Radioisotopes; D007700:Kinetics; D007962:Leukocytes / Q000502:physiology*; D008168:Lung / Q000098:blood supply / Q000473:pathology; D055370:Lung Injury; D009504:Neutrophils / Q000502:physiology; D011651:Pulmonary Artery / Q000503:physiopathology; D013552:Swine; D014655:Vascular Resistance / Q000187:drug effects
D007205:Indium Radioisotopes; D016285:Iloprost