Developmental changes in serum IGF-1 and IGFBP levels and liver IGFBP-3 mRNA expression in intrauterine growth-retarded and control swine.
The 29 M(r) x 10(-3) IGFBP was significantly elevated (P < 0.01) in IUGR piglets at 90 days fetally and at birth. Developmentally, 29 M(r) x 10(-3) IGFBP levels were higher fetally and at birth than at 21 and 49 days of age (P < 0.05). At 90 days fetally, hepatic IGFBP-3 mRNA levels were very high, while circulating levels of IGFBP-3 were extremely low whereas postnatally, hepatic IGFBP-3 mRNA and serum IGFBP-3 levels were parallel. This study provides new information concerning the developmental expression of IGFBP-3 and the relationship between serum levels of the 29 M(r) x 10(-3) IGFBP and IUGR in swine.
Kampman
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KA
Department of Animal Science, Ohio State University, Ohio Agriculture Research and Development Center, Columbus 43210.
Ramsay
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White
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D000818:Animals; D000831:Animals, Newborn; D015152:Blotting, Northern; D002352:Carrier Proteins / Q000235:genetics* / Q000378:metabolism; D005317:Fetal Growth Retardation / Q000662:veterinary*; D005326:Fetal Proteins / Q000378:metabolism; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008099:Liver / Q000378:metabolism; D012333:RNA, Messenger / Q000096:biosynthesis; D011863:Radioimmunoassay; D013002:Somatomedins / Q000378:metabolism*; D013552:Swine / Q000097:blood / Q000196:embryology / Q000378:metabolism*
D002352:Carrier Proteins; D005326:Fetal Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D012333:RNA, Messenger; D013002:Somatomedins; D007334:Insulin-Like Growth Factor I