title: [The quality of the preservation of lungs using different solutions (an experimental study)].
abstract: Effects of different perfusion conditions and storage of isolated dog lungs on the process of edema development were studied. Sixty-nine mongrel dogs were used in the study. In case of a 15 min perfusion via the pulmonary artery and 12 h storage lung condition depended mainly on the type of solution and addition of protective drugs to this solution. Euro-Collins and low-potassium electrolytic solution markedly increased capillary hydrostatic pressure and drastically reduced plasma colloid-osmotic pressure. As a result filtration coefficient increased and as soon as an hour after reperfusion onset a marked pulmonary edema developed. Use of LPD solution without drugs added for 2.5 h reperfusion was associated with a moderate increase of capillary hydrostatic pressure and negligible decrease of plasma colloid-osmotic pressure. If the reperfusion were longer plasma colloid-osmotic pressure reduced, this leading to development of moderate pulmonary edema. A 15 min lung perfusion via the pulmonary artery and 12 h storage at 1 degree C in LPD solution with membrane protectors and antioxidants was associated with virtually unchanged capillary hydrostatic pressure, plasma colloid-osmotic pressure, and filtration coefficient and, hence, no pulmonary edema.
authors.forename: G M
authors.initials: GM
authors.lastname: Khodzhimatov
authors.forename: R V
authors.initials: RV
authors.lastname: Movsesov
authors.forename: N A
authors.initials: NA
authors.lastname: Zhavoronkov
authors.forename: A G
authors.initials: AG
authors.lastname: Ivanova
authors.forename: I L
authors.initials: IL
authors.lastname: Zhidkov
authors.forename: G F
authors.initials: GF
authors.lastname: Sheremet'eva
authors.forename: I I
authors.initials: II
authors.lastname: Dement'eva
authors.forename: M I
authors.initials: MI
authors.lastname: Perel'man
mesh_terms: D000818:Animals; D000975:Antioxidants; D003911:Dextrans; D004285:Dogs; D005069:Evaluation Studies as Topic; D005260:Female; D005947:Glucose; D006982:Hypertonic Solutions; D008168:Lung / Q000473:pathology / Q000502:physiology*; D008297:Male; D009926:Organ Preservation / Q000379:methods*; D010477:Perfusion / Q000295:instrumentation / Q000379:methods; D011654:Pulmonary Edema / Q000209:etiology / Q000473:pathology; D015427:Reperfusion Injury / Q000209:etiology / Q000473:pathology; D013997:Time Factors
chemical_list: D000975:Antioxidants; D003911:Dextrans; C037096:Euro-Collins' solution; D006982:Hypertonic Solutions; C083290:low potassium dextran glucose solution; D005947:Glucose