Recent studies on the characterization of loop diuretics.
This article provides a survey of transport mechanisms in the loop of Henle and of secondary effects on electrolyte excretion of loop diuretics. Results are presented of experiments that define ion transport in the thick ascending limb. New data on ion channels and transport regulation in this tubule segment are summarized. In addition, the mechanisms underlying enhanced sodium chloride and water transport after diuretics in tubule segments that are located downstream of the loop of Henle are surveyed. Finally, the effects of K depletion and chronic metabolic acidosis on diuretic potency of torasemide as well as possible antialdosterone effects of torasemide are evaluated.
Giebisch
G
G
Department of Cellular and Molecular Physiology, Yale University School of Medicine, New Haven, Connecticut 06510.
Klein-Robbenhaar
G
G
D000818:Animals; D004232:Diuretics / Q000494:pharmacology*; D006801:Humans; D007473:Ion Channels / Q000187:drug effects; D017136:Ion Transport / Q000187:drug effects; D008138:Loop of Henle / Q000187:drug effects* / Q000378:metabolism; D013449:Sulfonamides / Q000494:pharmacology*; D000077786:Torsemide
D004232:Diuretics; D007473:Ion Channels; D013449:Sulfonamides; D000077786:Torsemide