title: S.C.S. effectiveness in patients affected by peripheral chronic arterial disease: our 5 years experience.
abstract: Spinal cord stimulation (S.C.S.) showed a valid clinical effect in the treatment of chronic obliterative arteriopathy of the lower limbs at an advanced stage (III-IV stages) and of phantom limb pain syndrome (P.L.P.S.). Secretion patterns of various biochemical mediators were evaluated and mechanism, by which analgesic and vasodilatator actions occur, were thus accounted for. There is not agreement on this subject. We report our experience on 60 patients (age range 28-91), observed over the period 1987-92. Blood values of some chemical mediators (beta-endorphins, Kinins, Serotonin, PGE) were determined before and after stabilization of the S.C.S. implant (from 2 up to 6 months) and compared with the objective clinical and TCpO2 data. Statistical significance was checked of variations obtained (Student's "t" test). High significant increase of TCpO2, beta-endorphins, PGE, (p < 0.01) and the Kinins (p < 0.05) was found but there were no significant alteration of Serotonin. Results are explained and an S.C.S. effect at the spinal cord metamer level with a cortical integration (pointed out by the increase of the beta-endorphins) is suggested. Analgesic effectiveness and vasodilatator action of S.C.S. implant is stressed as long as it is carried out only when a correct indication is established in the absence of contraindications or important risk.
authors.affiliation: Department of Surgical and Anatomical Sciences, University of Palermo, Italy.
authors.forename: I
authors.initials: I
authors.lastname: Cassina
authors.forename: N M
authors.initials: NM
authors.lastname: Pinelli
authors.forename: E
authors.initials: E
authors.lastname: Bentivegna
authors.forename: F
authors.initials: F
authors.lastname: Messina
authors.forename: S
authors.initials: S
authors.lastname: Piazza
authors.forename: C
authors.initials: C
authors.lastname: Comandè
authors.forename: S
authors.initials: S
authors.lastname: Lo Bosco
authors.forename: F
authors.initials: F
authors.lastname: Talarico
authors.forename: M
authors.initials: M
authors.lastname: Palazzo Adriano
authors.forename: V
authors.initials: V
authors.lastname: Candiloro
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001157:Arterial Occlusive Diseases / Q000097:blood / Q000628:therapy*; D004599:Electric Stimulation Therapy; D004723:Endorphins / Q000097:blood; D005260:Female; D006801:Humans; D007705:Kinins / Q000097:blood; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D016491:Peripheral Vascular Diseases / Q000097:blood / Q000628:therapy*; D010591:Phantom Limb / Q000628:therapy; D011458:Prostaglandins E / Q000097:blood; D012701:Serotonin / Q000097:blood; D013116:Spinal Cord / Q000503:physiopathology*
chemical_list: D004723:Endorphins; D007705:Kinins; D011458:Prostaglandins E; D012701:Serotonin