Inhibition of human immunodeficiency virus type 1 replication by human interferons alpha, beta and gamma.
The effect of various preparations of human interferon (HuIFN) upon human immunodeficiency virus (HIV-1) replication in cell lines and primary cultures of peripheral blood lymphocytes (PBL) was investigated. Natural interferon alpha (nHuIFN-alpha) exhibited a much higher inhibitory effect upon HIV-1 replication than did recombinant HuIFN-alpha (rHuIFN-alpha).
Yamamoto
J K
JK
Department of Medicine, School of Veterinary Medicine, University of California, Davis 95616.
Kruzel
M L
ML
Louie
H
H
Georgiades
J A
JA
D002460:Cell Line; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology; D016899:Interferon-beta / Q000494:pharmacology; D007371:Interferon-gamma / Q000494:pharmacology; D007372:Interferons / Q000494:pharmacology*; D008214:Lymphocytes / Q000382:microbiology; D014779:Virus Replication / Q000187:drug effects*
D016898:Interferon-alpha; D016899:Interferon-beta; D007371:Interferon-gamma; D007372:Interferons