[Evaluation of adequate heparinization during artificial circulation in the framework of prolonged intraoperative administration of high doses of aprotinin].
The aim of this research was to evaluate the effect of high aprotinin doses on activated coagulation time (ACT) in patients with aortocoronary bypass. A total of 100 patients were examined. All of them were administered in a double blind test either aprotinin or placebo in standard doses. Our results permit a conclusion that adequate heparinization during aprotinin therapy can be achieved at ACT values more than 750 sec and protamine sulphate dose should be estimated from initially administered heparin dose. With ACT values exceeding twofold the usual ones there was no evidence of excessive heparinization leading to marked thrombocytopenia and bleeding.
Dement'eva
I I
II
Charnaia
M A
MA
Shabalkin
B V
BV
Iavorovskiĭ
A G
AG
Piatnitskaia
G Kh
GKh
D000328:Adult; D000368:Aged; D007611:Aprotinin / Q000008:administration & dosage* / Q000494:pharmacology; D001777:Blood Coagulation / Q000187:drug effects; D001780:Blood Coagulation Tests; D001026:Coronary Artery Bypass; D004311:Double-Blind Method; D005260:Female; D006493:Heparin / Q000008:administration & dosage* / Q000494:pharmacology; D006801:Humans; D007430:Intraoperative Care; D008297:Male; D008875:Middle Aged
D006493:Heparin; D007611:Aprotinin