Lead effect on the oxidation resistance of erythrocyte membrane in rat triton-induced hyperlipidemia.
The anemia observed in severe chronic lead poisoning is in part attributable to alterations in the erythrocyte physicochemical properties. Since they are partly related to the membrane lipid composition, the aim of the present study was to determine the effects of a triton-induced hyperlipidemia on the resistance to oxidation of erythrocyte membranes in lead-treated Wistar rats. Our results showed that triton administration to lead-treated rats induced an increase in erythrocyte choline phospholipid levels together with a significant decrease in the erythrocyte membrane lipid resistance to oxidation. These results led us to suggest that anemia in lead poisoning is linked to interactions between lead present in the membrane and plasma phospholipids. Their increase in rat hyperlipidemia induced by triton resulted in a decrease in the membrane resistance to oxidation and finally in an erythrocyte fragility leading to their destruction.
Zimmermann
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Department of Biochemistry, Faculty of Medicine Paris-Ouest, UFR des Saints Pères, France.
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D000818:Animals; D004910:Erythrocyte Membrane / Q000187:drug effects / Q000378:metabolism*; D005227:Fatty Acids / Q000097:blood; D005260:Female; D006949:Hyperlipidemias / Q000139:chemically induced / Q000378:metabolism*; D007854:Lead / Q000097:blood / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008055:Lipids / Q000097:blood; D010084:Oxidation-Reduction; D010949:Plasma / Q000737:chemistry; D011092:Polyethylene Glycols; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013054:Spectrophotometry, Atomic; D017392:Thiobarbituric Acid Reactive Substances / Q000378:metabolism; D014131:Trace Elements / Q000097:blood; D015430:Weight Gain / Q000187:drug effects
D005227:Fatty Acids; D008055:Lipids; D017392:Thiobarbituric Acid Reactive Substances; D014131:Trace Elements; D007854:Lead; D011092:Polyethylene Glycols