title: Sweet's syndrome associated with G-CSF.
abstract: Sweet's syndrome (SS) developed in two patients with acute myeloid leukaemia (AML) treated with granulocyte colony stimulating factor (G-CSF) for febrile neutropenia due to AML chemotherapy. Fever, painful skin and conjunctival lesions developed and neutrophilic infiltration was detected at biopsy specimens. Neutrophilia was not detected. Skin lesions regressed within 1-2 weeks and conjunctival lesions within 4 weeks following the cessation of G-CSF. We conclude that SS may be a complication of G-CSF therapy and tender skin and/or conjunctival lesions developing during G-CSF therapy should suggest the possibility of SS.
authors.affiliation: Department of Oncology, Cukurova University Faculty of Medicine, Balcali, Adana, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Paydaş
authors.forename: B
authors.initials: B
authors.lastname: Sahin
authors.forename: E
authors.initials: E
authors.lastname: Seyrek
authors.forename: M
authors.initials: M
authors.lastname: Soylu
authors.forename: G
authors.initials: G
authors.lastname: Gonlusen
authors.forename: A
authors.initials: A
authors.lastname: Acar
authors.forename: I
authors.initials: I
authors.lastname: Tuncer
mesh_terms: D000208:Acute Disease; D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D007951:Leukemia, Myeloid / Q000188:drug therapy; D008297:Male; D009503:Neutropenia / Q000139:chemically induced / Q000188:drug therapy; D016463:Sweet Syndrome / Q000139:chemically induced*
chemical_list: D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor