Characterization and decomposition of voltage-activated ionic currents using a fitting numerical method.
The application of a computer-based numerical method for fast determination of the kinetic parameters of voltage-activated ionic currents is described. Currents with different kinetics and ionic backgrounds are fitted satisfactorily with Hodgkin-Huxley-like functions, and multicomponent currents are decomposed. The method offers a way to separate ionic-current components without pharmacological isolation.
Szücs
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Balaton Limnological Research Institute of the Hungarian Academy of Sciences, Tihany, Hungary.
D000465:Algorithms; D000818:Animals; D003627:Data Interpretation, Statistical; D004594:Electrophysiology / Q000379:methods*; D006372:Helix, Snails / Q000502:physiology; D007473:Ion Channels / Q000502:physiology*; D008433:Mathematics; D009474:Neurons / Q000502:physiology; D015221:Potassium Channels / Q000502:physiology; D012984:Software
D007473:Ion Channels; D015221:Potassium Channels