Serum soluble E-selectin levels in Kawasaki disease.
Serum sE-selectin levels in KD were tested. In the KD patients' sera during the acute phase, the levels of circulating sE-selectin were markedly elevated (27.5 +/- 10.9 ng/ml) compared to 3.1 +/- 1.0 ng/ml in the control subjects (p < 0.0001). The serum sE-selectin levels remained significantly elevated in the subacute phase (16.2 +/- 7.3 ng/ml; p < 0.005). The acute phase sE-selectin levels and TNF-alpha correlated well in a linear pattern (r2 = 0.64, p < 0.01). Also the acute phase sE-selectin levels and IL-6 were well correlated (r2 = 0.54, p < 0.05). The elevated serum sE-selectin levels in patients with KD provides additional evidence for the relationship between acute vasculitis and serum sE-selectin.
Kim
D S
DS
Department of Pediatrics, Yonsei University College of Medicine, Seoul, Korea.
Lee
K Y
KY
D000209:Acute-Phase Proteins / Q000032:analysis* / Q000096:biosynthesis; D000210:Acute-Phase Reaction / Q000276:immunology; D015415:Biomarkers / Q000097:blood; D015815:Cell Adhesion Molecules / Q000096:biosynthesis / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D003327:Coronary Disease / Q000209:etiology / Q000517:prevention & control; D019040:E-Selectin; D005260:Female; D006801:Humans; D007223:Infant; D015850:Interleukin-6 / Q000096:biosynthesis / Q000097:blood; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000276:immunology* / Q000503:physiopathology*; D011971:Receptors, Immunologic / Q000032:analysis* / Q000096:biosynthesis; D012044:Regression Analysis; D012720:Severity of Illness Index; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis / Q000096:biosynthesis
D000209:Acute-Phase Proteins; D015415:Biomarkers; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D015850:Interleukin-6; D011971:Receptors, Immunologic; D014409:Tumor Necrosis Factor-alpha