title: Growth, hemorrhage, and regression of multiple intracerebral vasoformative tumors: report of an unusual case.
abstract: A rare case of multiple hemorrhagic vascular tumors of the cerebrum and cerebellum is reported. Computed tomographic scans in a 16-year-old girl revealed multifocal brain lesions with "jewel ring"-like areas of contrast enhancement. An old hematoma cavity was found inside the surgical specimen. Histologically, it was a vascular tumor composed of anastomosing vascular channels with proliferating endothelial cells and hemorrhages at different stages. Upon further histopathological study, this lesion could not be classified as any known vascular tumor entity, although it resembled some vascular tumors, such as cavernous hemangioma and hemangioendothelioma. The patient received steroid and alpha interferon treatment. The lesions initially increased in number once, then resolved 10 months after onset. The neuroradiological and histopathological features in the present case were characteristic, and the clinical course was unusual.
authors.affiliation: Department of Neurological Surgery, Kagawa Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Honma
authors.forename: T
authors.initials: T
authors.lastname: Fujiwara
authors.forename: N
authors.initials: N
authors.lastname: Sasaoka
authors.forename: S
authors.initials: S
authors.lastname: Nagao
mesh_terms: D000293:Adolescent; D000305:Adrenal Cortex Hormones / Q000008:administration & dosage; D001932:Brain Neoplasms / Q000473:pathology / Q000601:surgery*; D002455:Cell Division / Q000502:physiology; D002533:Cerebral Angiography; D002543:Cerebral Hemorrhage / Q000473:pathology / Q000601:surgery*; D003131:Combined Modality Therapy; D003937:Diagnosis, Differential; D005260:Female; D005500:Follow-Up Studies; D006390:Hemangioendothelioma / Q000473:pathology / Q000601:surgery; D006391:Hemangioma / Q000473:pathology / Q000601:surgery*; D006392:Hemangioma, Cavernous / Q000473:pathology / Q000601:surgery; D006801:Humans; D016898:Interferon-alpha / Q000008:administration & dosage; D009378:Neoplasms, Multiple Primary / Q000473:pathology / Q000601:surgery*; D014057:Tomography, X-Ray Computed
chemical_list: D000305:Adrenal Cortex Hormones; D016898:Interferon-alpha