Leukotrienes C4 and D4 promote angiogenesis via a receptor-mediated interaction.
The involvement of leukotrienes in angiogenesis was investigated in the in vivo chick chorioallantoic membrane system. In this system leukotrienes C4 and D4 promoted angiogenesis in a dose-dependent manner. Leukotriene B4 was ineffective. The potent and selective peptidyl leukotriene receptor antagonist, SK&F 104353-Z2, abolished the angiogenic effects of leukotrienes C4 and D4 and reduced unstimulated angiogenesis. These results indicate that leukotrienes C4 and D4 promote angiogenesis in the chick chorioallantoic membrane via a receptor-mediated interaction.
Tsopanoglou
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NE
Department of Pharmacology, Medical School, University of Patras, Greece.
Pipili-Synetos
E
E
Maragoudakis
M E
ME
D000818:Animals; D002642:Chick Embryo; D003998:Dicarboxylic Acids / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005321:Extraembryonic Membranes / Q000187:drug effects / Q000378:metabolism; D017997:Leukotriene C4 / Q000494:pharmacology*; D017998:Leukotriene D4 / Q000494:pharmacology*; D009389:Neovascularization, Pathologic / Q000139:chemically induced*; D018077:Receptors, Leukotriene / Q000187:drug effects*; D013189:SRS-A / Q000037:antagonists & inhibitors
D003998:Dicarboxylic Acids; D018077:Receptors, Leukotriene; D013189:SRS-A; D017997:Leukotriene C4; D017998:Leukotriene D4; C052393:pobilukast