Glutamate receptor update.
The past year has seen significant advances in matching the actions of recombinant glutamate receptors with the actions of native receptors, and in mapping their distribution and regulation. The discovery of a novel RNA editing mechanism for AMPA receptors and a revised view of the transmembrane topology of the NMDA receptor subunit, NR1, are particularly noteworthy. Seven metabotropic glutamate receptor subtypes have been identified with several interesting expression patterns and transduction mechanisms; results from work on these subtypes has led to a provocative model of the ligand-binding site. Functional studies of metabotropic receptors have been enhanced by the development of the first subtype-specific antagonist.
Westbrook
G L
GL
Oregon Health Sciences University, Portland 97201.
D000818:Animals; D001483:Base Sequence; D006801:Humans; D007473:Ion Channels / Q000235:genetics / Q000378:metabolism; D007700:Kinetics; D008958:Models, Molecular; D008969:Molecular Sequence Data; D017393:RNA Editing; D018091:Receptors, AMPA / Q000235:genetics; D017470:Receptors, Glutamate / Q000235:genetics*; D018092:Kainic Acid Receptors / Q000235:genetics; D018094:Receptors, Metabotropic Glutamate / Q000235:genetics; D014018:Tissue Distribution
D007473:Ion Channels; D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D018092:Kainic Acid Receptors; D018094:Receptors, Metabotropic Glutamate