title: At least two different regions are involved in allelic imbalance on chromosome arm 16q in breast cancer.
abstract: Loss of heterozygosity (LOH) or allelic imbalance, the latter term referring to both loss and gain of an allele, on the long arm of chromosome 16 has been repeatedly found in cancers of, e.g., the breast and prostate. This indicates the presence of one or more tumor suppressor genes on 16q. To locate the gene(s) more precisely, a detailed allelic imbalance map of 20 polymorphic markers on this chromosome arm was made for 79 sporadic breast carcinomas. LOH of one or more markers was found in 63% of the tumors. Some had allelic imbalance on a region of 16q which failed to overlap with the LOH in other tumors. We therefore assigned two separate "smallest regions of overlap" to 16q and suggest that this chromosome arm contains at least two different tumor suppressor genes.
authors.affiliation: Department of Pathology, University of Leiden, The Netherlands.
authors.forename: A M
authors.initials: AM
authors.lastname: Cleton-Jansen
authors.forename: E W
authors.initials: EW
authors.lastname: Moerland
authors.forename: N J
authors.initials: NJ
authors.lastname: Kuipers-Dijkshoorn
authors.forename: D F
authors.initials: DF
authors.lastname: Callen
authors.forename: G R
authors.initials: GR
authors.lastname: Sutherland
authors.forename: B
authors.initials: B
authors.lastname: Hansen
authors.forename: P
authors.initials: P
authors.lastname: Devilee
authors.forename: C J
authors.initials: CJ
authors.lastname: Cornelisse
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics*; D002869:Chromosome Aberrations; D002885:Chromosomes, Human, Pair 16 / Q000648:ultrastructure*; D016147:Genes, Tumor Suppressor; D005819:Genetic Markers; D006579:Heterozygote; D006801:Humans; D009857:Oncogenes; D012150:Polymorphism, Restriction Fragment Length; D017384:Sequence Deletion
chemical_list: D005819:Genetic Markers