title: Reversible myoclonic encephalopathy revealing the AIDS-dementia complex.
abstract: A 40-year-old HIV-positive right handed homosexual man was admitted for progressive mental deterioration coexisting with permanent segmental middle-amplitude arrhythmic, asynchronous and asymmetrical myoclonic jerks. EEG showed fronto-central bursts of rhythmic triphasic 1.5-2 Hz sharp waves similar to the characteristic periodic pattern of Jakob-Creutzfeldt disease. Biological procedures were negative, thus eliminating a metabolic encephalopathy. Dramatic neurological improvement occurred shortly after initiation of i.v. and then oral zidovudine which produced perfect EEG normalisation. This unusual electroclinical presentation of the AIDS-dementia complex underlines the fact that this affection may present a diagnostic challenge, particularly in individuals in whom HIV infection is unknown.
authors.affiliation: Service de Neurologie, Hôpital Pasteur, Nice, France.
authors.forename: P
authors.initials: P
authors.lastname: Thomas
authors.forename: M
authors.initials: M
authors.lastname: Borg
mesh_terms: D015526:AIDS Dementia Complex / Q000150:complications*; D000328:Adult; D001921:Brain / Q000473:pathology / Q000503:physiopathology*; D004569:Electroencephalography; D004831:Epilepsies, Myoclonic / Q000209:etiology / Q000503:physiopathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male