Calphostin C, a potent and specific inhibitor of protein kinase C, reduces phorbol ester-induced but not primary Ca(2+)-induced catecholamine secretion from digitonin-permeabilized bovine adrenal medullary cells.
Isosaki
M
M
Department of Pharmacology, Nara Medical University, Kashihara, Japan.
Minami
N
N
Nakashima
T
T
D000313:Adrenal Medulla / Q000187:drug effects* / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D002463:Cell Membrane Permeability; D004072:Digitonin / Q000494:pharmacology*; D004347:Drug Interactions; D009281:Naphthalenes; D011083:Polycyclic Compounds / Q000494:pharmacology*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors*; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology*
D002395:Catecholamines; D009281:Naphthalenes; D011083:Polycyclic Compounds; D011493:Protein Kinase C; C058819:calphostin C; D004072:Digitonin; D013755:Tetradecanoylphorbol Acetate; D002118:Calcium