Synthetic gonadotrophin-releasing hormone (GnRH) vaccines incorporating GnRH and synthetic T-helper epitopes.
A vaccine against the gonadotrophin-releasing hormone (GnRH) is being developed as an immunological method for treatment of prostatic hypertrophy, based on the observation that active immunization against GnRH leads to the production of anti-GnRH antibodies which results in the shrinkage of the prostate gland. We have been investigating the regulation of anti-GnRH antibody responses by carrier molecules. In previous studies we showed that the use of large protein molecules as carriers limits the use of such a vaccine owing to potential problems of carrier-induced anti-haptenic suppression. In this report we show that synthetic T-helper epitopes can be used as carriers for the generation of anti-GnRH antibody responses.
Sad
S
S
National Institute of Immunology, New Delhi, India.
Chauhan
V S
VS
Arunan
K
K
Raghupathy
R
R
D000818:Animals; D000906:Antibodies / Q000276:immunology; D000917:Antibody Formation; D004168:Diphtheria Toxoid / Q000276:immunology / Q000494:pharmacology; D000939:Epitopes / Q000276:immunology*; D007987:Gonadotropin-Releasing Hormone / Q000276:immunology*; D007114:Immunization; D000922:Immunotoxins / Q000276:immunology / Q000494:pharmacology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D010446:Peptide Fragments / Q000276:immunology / Q000494:pharmacology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology*; D018074:Vaccines, Conjugate / Q000276:immunology / Q000494:pharmacology*
D000906:Antibodies; D004168:Diphtheria Toxoid; D000939:Epitopes; D000922:Immunotoxins; D010446:Peptide Fragments; D018074:Vaccines, Conjugate; D007987:Gonadotropin-Releasing Hormone