title: Ciliary cation conductances in olfactory receptor cells of the clawed toad Xenopus laevis.
abstract: One transduction pathway in olfactory receptor neurons is a cascade of receptors, a G-protein, adenylate cyclase, cAMP, and a cyclic nucleotide-activated cation conductance. Here, we show that this conductance is also present in olfactory cells of Xenopus laevis. With optical recordings from the cell's dendritic knob, we show that this conductance, when activated by odors, leads to an increase of intracellular calcium. It is further shown that there is a second cation conductance on the cilia of these cells which is modulated by calcium and can be activated by the application of odorants.
authors.affiliation: Physiologisches Institut der Universität, Göttingen, FRG.
authors.forename: D
authors.initials: D
authors.lastname: Schild
mesh_terms: D015124:8-Bromo Cyclic Adenosine Monophosphate / Q000494:pharmacology; D000818:Animals; D002118:Calcium / Q000494:pharmacology; D015220:Calcium Channels / Q000187:drug effects / Q000502:physiology; D002412:Cations / Q000378:metabolism; D002923:Cilia / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism; D004553:Electric Conductivity; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008465:Mechanoreceptors / Q000502:physiology*; D008564:Membrane Potentials / Q000187:drug effects; D009812:Odorants; D015398:Signal Transduction; D012903:Smell / Q000502:physiology*; D014982:Xenopus laevis
chemical_list: D015220:Calcium Channels; D002412:Cations; D007473:Ion Channels; D015124:8-Bromo Cyclic Adenosine Monophosphate; D015544:Inositol 1,4,5-Trisphosphate; D000242:Cyclic AMP; D002118:Calcium