Anti-allergy actions of alkylphenyl alpha-D-mannopyranosides.
The inhibitory effects of alkylphenyl alpha-D-mannopyranosides on histamine release from rat peritoneal mast cells induced by an antigen-antibody reaction were examined. Among the compounds tested, 2,4,6-trimethylphenyl alpha-D-mannopyranoside exhibited the strongest inhibitory effect. Furthermore, the 2,4,6-trimethylphenyl alpha-D-mannopyranoside suppressed the Schultz-Dale reaction and 48 h homologous passive cutaneous anaphylaxis (PCA), suggesting that this compound may be a useful lead compound in the development of novel anti-allergy drugs.
Wang
T C
TC
Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Japan.
Kakegawa
H
H
Matsumoto
H
H
Satoh
T
T
D000818:Animals; D000001:Calcimycin / Q000494:pharmacology; D006636:Histamine Release / Q000187:drug effects*; D006967:Hypersensitivity / Q000188:drug therapy*; D008297:Male; D008362:Mannosides / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects*; D010537:Peritoneum; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
D008362:Mannosides; D000001:Calcimycin