Stimulation and inhibition of angiogenesis by placental proliferin and proliferin-related protein.
In many mammalian species, the placenta is the site of synthesis of proteins in the prolactin and growth hormone family. Analysis of two such proteins, proliferin (PLF) and proliferin-related protein (PRP), revealed that they are potent regulators of angiogenesis; PLF stimulated and PRP inhibited endothelial cell migration in cell culture and neovascularization in vivo. The mouse placenta secretes an angiogenic activity during the middle of pregnancy that corresponds primarily to PLF, but later in gestation releases a factor that inhibits angiogenesis, which was identified as PRP. Incubation of placental tissue with PLF led to the specific binding of this hormone to capillary endothelial cells. Thus PLF and PRP may regulate the initiation and then the cessation of placental neovascularization.
Jackson
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Department of Biochemistry, Molecular Biology, and Cell Biology, Northwestern University, Evanston, IL 60208.
Volpert
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Bouck
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Linzer
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D000818:Animals; D002417:Cattle; D002465:Cell Movement / Q000187:drug effects; D003315:Cornea / Q000098:blood supply; D046508:Culture Techniques; D004730:Endothelium, Vascular / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology; D006023:Glycoproteins / Q000378:metabolism / Q000494:pharmacology*; D006133:Growth Substances / Q000378:metabolism / Q000494:pharmacology*; D036341:Intercellular Signaling Peptides and Proteins; D009389:Neovascularization, Pathologic; D010920:Placenta / Q000098:blood supply*; D011247:Pregnancy; D011257:Pregnancy Proteins / Q000494:pharmacology*; D011388:Prolactin; D051381:Rats
D006023:Glycoproteins; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; C057074:Plfr protein, mouse; D011257:Pregnancy Proteins; C000634106:Prl2c2 protein, mouse; C489178:Prl7d1 protein, rat; D016222:Fibroblast Growth Factor 2; D011388:Prolactin