Depressed hepatic dihydropyrimidine dehydrogenase activity and fluorouracil-related toxicities.
Stéphan
F
F
Hôpital Tenon, Paris, France.
Etienne
M C
MC
Wallays
C
C
Milano
G
G
Clergue
F
F
D000230:Adenocarcinoma / Q000201:enzymology; D000328:Adult; D000964:Antimetabolites, Antineoplastic / Q000009:adverse effects* / Q000378:metabolism; D001927:Brain Diseases / Q000139:chemically induced* / Q000201:enzymology; D002430:Cecal Neoplasms / Q000201:enzymology; D042943:Dihydrouracil Dehydrogenase (NADP); D005260:Female; D005472:Fluorouracil / Q000009:adverse effects* / Q000378:metabolism; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000556:secondary; D010088:Oxidoreductases / Q000378:metabolism*; D015275:Tumor Lysis Syndrome / Q000201:enzymology / Q000209:etiology*
D000964:Antimetabolites, Antineoplastic; D010088:Oxidoreductases; D042943:Dihydrouracil Dehydrogenase (NADP); D005472:Fluorouracil