Trilineage response in severe aplastic anemia following long-term therapy with recombinant human granulocyte colony-stimulating factor.
We investigated the effects of long-term therapy with recombinant human granulocyte colony-stimulating factor (rhG-CSF) in a 69-year-old man with severe aplastic anemia (SAA). The patient was too old to receive a bone marrow transplantation, and high-dose methylprednisolone and antilymphocyte globulin were ineffective. We administered rhG-CSF in combination with metenolone acetate. Trilineage blood cell components were recovered 6 months later. These findings suggest that long-term G-CSF therapy may be beneficial in patients with SAA who are not candidates for bone marrow transplantation.
Ashihara
E
E
Second Department of Medicine, Kyoto Prefectural University of Medicine, Japan.
Shimazaki
C
C
Hirata
T
T
Okawa
K
K
Oku
N
N
Goto
H
H
Inaba
T
T
Fujita
N
N
Nakagawa
M
M
D000368:Aged; D000741:Anemia, Aplastic / Q000097:blood / Q000473:pathology / Q000628:therapy*; D001772:Blood Cell Count; D001853:Bone Marrow / Q000473:pathology; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011994:Recombinant Proteins / Q000627:therapeutic use
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor