Effect of platelet activating factor (PAF) on the formation of blood vessels in subcutaneous implants in mice.
Angiogenesis accompanies inflammatory processes and many other pathological conditions. We have studied the effect of platelet-activating factor (PAF) a well-known inflammatory mediator, as a promoter of angiogenesis in the sponge implant model in mice. Development of blood vessels and blood flow were monitored by use of a 133Xe washout technique. The results showed PAF to have angiogenic activity, which was inhibited by WEB 2086, and the PAF-induced vasculature to have normal pharmacological reactivity.
Andrade
S P
SP
Department of Physiology and Biophysics, Federal University of Minas Gerais, Belo Horizonte, Brazil.
Vieira
L B
LB
Bakhle
Y S
YS
Piper
P J
PJ
D000804:Angiotensin II / Q000494:pharmacology; D000818:Animals; D016232:Endothelins / Q000494:pharmacology; D007700:Kinetics; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic; D010972:Platelet Activating Factor / Q000494:pharmacology*; D019736:Prostheses and Implants; D014980:Xenon Radioisotopes
D016232:Endothelins; D010972:Platelet Activating Factor; D014980:Xenon Radioisotopes; D000804:Angiotensin II