title: Juxtacrine intercellular signaling: another way to do it.
abstract: Intercellular interactions in which one cell sends a signal to another cell, inducing a change in function of the second cell, are common in morphogenesis, development, inflammation, and repair of the lung and other organs. In juxtacrine intercellular signaling, the molecule that induces the functional changes in the target cell remains associated with the plasma membrane of the signaling cell, rather than acting in the fluid phase. This feature distinguishes juxtacrine signaling from endocrine and paracrine stimulation and provides a mechanism for strict spatial control of activation of one cell by another. Juxtacrine signaling is likely to be common in physiologic events that require tight regulation, and disruption of juxtacrine signaling may lead to pathologic outcomes. In this minireview, general principles as well as several specific examples of juxtacrine signaling are discussed.
authors.affiliation: Nora Eccles Harrison Cardiovascular Research and Training Institute, University of Utah School of Medicine, Salt Lake City.
authors.forename: G A
authors.initials: GA
authors.lastname: Zimmerman
authors.forename: D E
authors.initials: DE
authors.lastname: Lorant
authors.forename: T M
authors.initials: TM
authors.lastname: McIntyre
authors.forename: S M
authors.initials: SM
authors.lastname: Prescott
mesh_terms: D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology; D002450:Cell Communication / Q000502:physiology*; D029721:Drosophila Proteins; D019040:E-Selectin; D005136:Eye Proteins / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000502:physiology; D010972:Platelet Activating Factor / Q000502:physiology; D011498:Protein Precursors / Q000502:physiology; D018000:Receptors, Peptide; D015398:Signal Transduction / Q000502:physiology*; D016211:Transforming Growth Factor alpha / Q000502:physiology
chemical_list: D015815:Cell Adhesion Molecules; D029721:Drosophila Proteins; D019040:E-Selectin; D005136:Eye Proteins; D008562:Membrane Glycoproteins; D010972:Platelet Activating Factor; D011498:Protein Precursors; D018000:Receptors, Peptide; D016211:Transforming Growth Factor alpha; C072141:boss protein, Drosophila; C052268:protransforming growth factor alpha