Induction of interferon by virus glycoprotein(s) in lymphoid cells through interaction with the cellular receptors via lectin-like action: an alternative interferon induction mechanism.
When animals and cells are infected with a virus, interferon is produced. Viral-nucleic acid is considered to be one of actual components for interferon induction. In addition, viral glycoproteins trigger interferon induction in lymphoid cells by membrane-membrane interaction via a lectin-like activity. A biological significance of lectin-like activity of viral glycoproteins is discussed.
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Department of Microbiology, Mie University School of Medicine, Japan.
D000818:Animals; D002460:Cell Line; D002462:Cell Membrane / Q000502:physiology; D016207:Cytokines / Q000502:physiology; D003599:Cytoskeleton / Q000502:physiology; D006023:Glycoproteins / Q000494:pharmacology / Q000502:physiology*; D007372:Interferons / Q000096:biosynthesis*; D037102:Lectins / Q000378:metabolism / Q000494:pharmacology; D008214:Lymphocytes / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism; D014764:Viral Proteins / Q000494:pharmacology / Q000502:physiology*; D018406:Virus Physiological Phenomena
D016207:Cytokines; D006023:Glycoproteins; D037102:Lectins; D011991:Receptors, Virus; D014764:Viral Proteins; D007372:Interferons