title: [High-dose progestational contraception: advantages].
abstract: In spite of the nearly total effectiveness of classic estrogen-progestogen oral contraception and its good overall tolerance, in a not inconsiderable number of situations yet, it is not possible to resort to it. These situations are the following: high blood pressure, hyperlipemia, diabetes, minor mastopathy, premenstrual tension either spontaneous or under estroprogestogen therapy. Macroprogestational contraception using either pregnanes (chlormadinone acetate) or nor-pregnanes, promegestone, nomegestrol acetate, can be then the right solution. Clinical and metabolic tolerance is excellent. In the occurrence of hypoestrogeny symptoms, a combination of nomegestrol acetate-estradiol 17 beta, transdermally administered, has given top results in a preliminary study.
authors.forename: C
authors.initials: C
authors.lastname: Jamin
mesh_terms: D000279:Administration, Cutaneous; D000328:Adult; D002715:Chlormadinone Acetate / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D003277:Contraceptives, Oral, Combined / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D004958:Estradiol / Q000097:blood / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D015994:Incidence; D008535:Megestrol; D008599:Menstruation Disturbances / Q000139:chemically induced / Q000453:epidemiology; D009649:Norpregnadienes / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D045167:Progesterone Congeners / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D011397:Promegestone / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D003277:Contraceptives, Oral, Combined; D009649:Norpregnadienes; D045167:Progesterone Congeners; D002715:Chlormadinone Acetate; D004958:Estradiol; C038501:nomegestrol acetate; D011397:Promegestone; D008535:Megestrol