Mutagenicity of mild gasification products in Salmonella typhimurium.
Mild gasification is a coal-conversion technology that is currently under development in order to help meet future energy needs. 7 products from this process were assayed for mutagenic activity in the pre-incubation variant of the Salmonella assay (Ames test) using both DMSO and Tween 80 as sample solvents. Significant mutagenic activity was detected only in the wide-boiling-point composite materials, and the amount of this activity was found to be dependent on the solvent utilized. The highest number of revertants detected were on TA98 and its O-acetyltransferase over-producing derivative, YG1024, in the presence of the S9 microsomal fraction. Aromatic amines were suggested as a possible source of the mutagenic activity elicited. An examination of the liquid and tar phases of one composite material (MG-120) indicated that the mutagenic activity was restricted to the tar phase.
Stamm
S C
SC
Microbiology Section, National Institute for Occupational Safety and Health, Morgantown, WV 26505-2888.
Lan
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W
Zhong
B Z
BZ
Whong
W Z
WZ
Ong
T
T
D003031:Coal / Q000633:toxicity*; D004121:Dimethyl Sulfoxide; D005579:Fossil Fuels / Q000633:toxicity; D009152:Mutagenicity Tests; D011136:Polysorbates; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics
D003031:Coal; D005579:Fossil Fuels; D011136:Polysorbates; D004121:Dimethyl Sulfoxide