title: Increase in serum alpha-fetoprotein without recurrent disease after hepatectomy for hepatocellular carcinoma.
abstract: The case of a 58-year-old man with clinically-stable and compensated HBsAg-positive liver cirrhosis is reported. In April 1991, the patient underwent partial hepatectomy to treat a solitary 3.5 cm hepatocellular carcinoma (HCC), (Edmonson scale I), in the 5th liver segment. His serum alpha-fetoprotein (AFP) level was 24 ng/ml. After hepatectomy, the AFP level dropped to 8 ng/ml, but between the 4th and 12th month it rose gradually from 72 ng/ml to 4,520 ng/ml. Hepatic recurrence of HCC was excluded, but a 6 cm solitary metastasis (Edmonson scale III-IV) was detected on the right adrenal. Adrenalectomy was performed and two months later the patient is doing well and his AFP level is 51 ng/ml. The methodological approach to diagnosis, treatment and follow-up of HCC, and the relationship between AFP and liver and metastatic HCC, are discussed.
authors.affiliation: Clinica Medica III, University of Modena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cristani
authors.forename: G
authors.initials: G
authors.lastname: Cioni
authors.forename: M
authors.initials: M
authors.lastname: De Santis
authors.forename: L
authors.initials: L
authors.lastname: Chianese
authors.forename: G
authors.initials: G
authors.lastname: Gozzetti
authors.forename: E
authors.initials: E
authors.lastname: Ventura
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000097:blood / Q000556:secondary / Q000601:surgery; D000315:Adrenalectomy; D006528:Carcinoma, Hepatocellular / Q000097:blood* / Q000556:secondary / Q000601:surgery; D006498:Hepatectomy; D006801:Humans; D008113:Liver Neoplasms / Q000097:blood* / Q000473:pathology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D000509:alpha-Fetoproteins / Q000378:metabolism*
chemical_list: D000509:alpha-Fetoproteins