[Common mechanisms of cardiac damage and adaptation in ischemia and reperfusion (components for the construction of the general theory of cardiac pathology)].
The paper deals with the common cellular and molecular mechanisms responsible for the development of cardiac abnormalities of various genesis. These include changes in cardiomyocytic energy supply processes; physicochemical states and structures of their membranes, in myocardial cell enzymatic activity, intra- and extracellular concentrations and ratios of ions to fluid, in cardiomyocytic electrophysiological parameters, their genetic programme and/or mechanisms of its implementation, in cardiac neurohumoral regulation. It also outlines the specific intra- and extracardiac mechanisms of adaptation of the heart in its lesion of various origin.
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D000818:Animals; D006801:Humans; D017202:Myocardial Ischemia / Q000503:physiopathology*; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology*