No linkage or association between multiple sclerosis and the myelin basic protein gene in affected sibling pairs.
Myelin basic protein was examined as a candidate gene for susceptibility to multiple sclerosis using two adjacent amplification fragment length polymorphisms (AmpFLPs), containing seven and six highly informative alleles respectively. No allelic association was found with multiple sclerosis, comparing 77 cases and 88 controls, and there was no evidence for linkage in 73 affected sibling pairs, using the methods of identity by descent and identity by state.
Wood
N W
NW
University of Cambridge Neurology unit, Addenbrooke's Hospital, UK.
Holmans
P
P
Clayton
D
D
Robertson
N
N
Compston
D A
DA
D000328:Adult; D000368:Aged; D000483:Alleles; D004276:DNA, Satellite / Q000235:genetics; D005784:Gene Amplification; D008040:Genetic Linkage; D006801:Humans; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000235:genetics*; D004676:Myelin Basic Protein / Q000235:genetics*; D010375:Pedigree; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid
D004276:DNA, Satellite; D004676:Myelin Basic Protein