title: Gynaecomastia caused by a primary mediastinal seminoma.
abstract: The case of a young man aged 26 is reported. He presented with a short history of painful gynaecomastia, and no other associated symptoms. Radiological investigations showed a mass in the anterior mediastinum. Endocrine investigations showed high circulating oestradiol and high hCG-beta levels. There was no evidence of primary testicular tumour or metastases. Surgical removal of the mediastinal mass led to normalization of oestradiol and hCG-beta levels and regression of gynaecomastia. Histology showed the tumour to be a primary mediastinal seminoma staining positively for hCG-beta. Further treatment consisted of chemotherapy with etoposide and cis-platinum. The patient has remained well with no evidence of disease recurrence. The tumour markers remain normal.
authors.affiliation: Department of Endocrinology, General Infirmary at Leeds, UK.
authors.forename: D K
authors.initials: DK
authors.lastname: Nagi
authors.forename: W G
authors.initials: WG
authors.lastname: Jones
authors.forename: P E
authors.initials: PE
authors.lastname: Belchetz
mesh_terms: D000328:Adult; D006063:Chorionic Gonadotropin / Q000097:blood; D018997:Chorionic Gonadotropin, beta Subunit, Human; D003131:Combined Modality Therapy; D004958:Estradiol / Q000097:blood; D006177:Gynecomastia / Q000097:blood / Q000209:etiology* / Q000628:therapy; D006801:Humans; D008297:Male; D008479:Mediastinal Neoplasms / Q000097:blood / Q000150:complications* / Q000628:therapy; D010446:Peptide Fragments / Q000097:blood; D018239:Seminoma / Q000097:blood / Q000150:complications* / Q000628:therapy
chemical_list: D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D010446:Peptide Fragments; D004958:Estradiol