Fas antigen mRNA induction in postischemic murine brain.
Fas antigen mRNA induction in the brain was examined using a transient global cerebral ischemia model in BALB/C mice. Northern blot analysis revealed little Fas antigen mRNA expression in the brains of sham-operated mice. A marked induction of Fas mRNA expression was detected in the brains of mice 6 h after 30 min of cerebral ischemia. These results suggest a possible apoptotic mechanism for cell death, mediated by the Fas antigen, in postischemic brain.
Matsuyama
T
T
Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Hata
R
R
Tagaya
M
M
Yamamoto
Y
Y
Nakajima
T
T
Furuyama
J
J
Wanaka
A
A
Sugita
M
M
D000818:Animals; D000954:Antigens, Surface / Q000235:genetics*; D017209:Apoptosis / Q000276:immunology*; D001483:Base Sequence; D004195:Disease Models, Animal; D002546:Ischemic Attack, Transient / Q000276:immunology*; D008297:Male; D008565:Membrane Proteins / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000096:biosynthesis*; D011956:Receptors, Cell Surface / Q000276:immunology*; D019014:fas Receptor
D000954:Antigens, Surface; D008565:Membrane Proteins; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D019014:fas Receptor