[Biorhythms of the lymphoid system and possibilities of immunomodulating chronotherapy].
The paper provides the authors' own data and the data available in the literature concerning diurnal rhythms of immunological parameters in the development of experimental immunopathological conditions. Desynchronizing these rhythms, a change in the light regime is shown to accelerate the time course of the development of an autoimmune process in mice. The potentialities of chronotherapy of experimental immunodeficiencies with thymic preparations have been studied. It is emphasized that chronobiological studies are particularly essential in solving the biomedical problems of the Far North with its extreme conditions and a great deal of desynchronizing factors.
Shurlygina
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Trufakin
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D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D002909:Chronobiology Phenomena; D002940:Circadian Rhythm; D016867:Immunocompromised Host; D008198:Lymph Nodes / Q000187:drug effects / Q000276:immunology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010455:Peptides / Q000494:pharmacology; D010507:Periodicity; D013154:Spleen / Q000187:drug effects / Q000276:immunology*; D013947:Thymosin / Q000031:analogs & derivatives*; D013949:Thymus Extracts / Q000494:pharmacology; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology*
D000276:Adjuvants, Immunologic; D010455:Peptides; D013949:Thymus Extracts; C065652:timoptin; D013947:Thymosin; C036191:T-activin