title: Dermatome mapping in the rat hindlimb by electrical stimulation of the spinal nerves.
abstract: In rats treated with Evans blue (i.v.), electrical stimulation of the lumbar spinal nerves produced an extravasation zone in the skin. Stimulation of L1 produced extravasation in the lower abdomen; that of L2, in the cranial region of the hindlimb; that of L3, in the ventral region of the hindlimb and the medial paw; that of L4, in the lateral region of the hindlimb and the middle paw; that of L5, in the caudal region of the hindlimb and the lateral paw; and that of L6, in the caudal region of the hindlimb and the scrotum. Since the substance P antagonist FK224 inhibited the extravasation caused by stimulation of the sciatic nerve, the extravasation zones appeared to be related to antidromic activation of afferent C-fibers. Thus, a dermatome of afferent C-fibers was revealed in rats.
authors.affiliation: Department of Orthopaedic Surgery, Chiba University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: Y
authors.initials: Y
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Sakamoto
mesh_terms: D000344:Afferent Pathways / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000502:physiology*; D001931:Brain Mapping; D004558:Electric Stimulation; D006470:Hemorrhage; D006614:Hindlimb / Q000294:innervation*; D008297:Male; D009412:Nerve Fibers / Q000187:drug effects / Q000502:physiology; D010456:Peptides, Cyclic / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012611:Scrotum / Q000294:innervation; D012867:Skin / Q000294:innervation*; D013127:Spinal Nerves / Q000502:physiology*; D013373:Substance P / Q000037:antagonists & inhibitors
chemical_list: D010456:Peptides, Cyclic; C075570:FK 224; D013373:Substance P