title: Localization of nitric oxide synthase immunoreactivity in mast cells of human nasal mucosa.
abstract: Nitric oxide (NO)-synthase immunoreactivity has been detected for the first time in mast cells of human normal nasal mucosa, with an antibody specific for neuronal NO-synthase. Intense immunoreactivity was revealed in secretion granules of mast cells but was found in mast cell granules free in the extracellular matrix only in some instances; no reactivity was found in the cytoplasm of this or other cell types. These findings suggest that human nasal mast cells contain a particulate isoform of NO-synthase, which shares epitopes with neuronal NO-synthase and is rapidly removed from granules upon exocytosis.
authors.affiliation: Department of Human Anatomy and Histology, Section E. Allara, University of Florence, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Bacci
authors.forename: R
authors.initials: R
authors.lastname: Arbi-Riccardi
authors.forename: B
authors.initials: B
authors.lastname: Mayer
authors.forename: C
authors.initials: C
authors.lastname: Rumio
authors.forename: M B
authors.initials: MB
authors.lastname: Borghi-Cirri
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D006801:Humans; D008297:Male; D008407:Mast Cells / Q000201:enzymology*; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D009297:Nasal Mucosa / Q000201:enzymology*; D019001:Nitric Oxide Synthase
chemical_list: D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases