Inhibition of eukaryote signal-regulated protein kinases by plant-derived catechin-related compounds.
The cladodes of Phyllocladus trichomanoides, the bark of Pseudotsuga menziesii and the heartwood of Acacia melanoxylon contain catechin derivatives that are potent inhibitors of rat brain protein kinase C. Most of these compounds are also inhibitors of bovine heart cyclic AMP-dependent protein kinase catalytic subunit and wheat Ca(2+)-dependent protein kinase. However, these compounds are either not inhibitors or are relatively poor inhibitors of avian myosin light chain kinase. The most potent protein kinase inhibitors are the procyanidin dimer, trimer and tetramer from the bark of Pseudotsuga menziesii. These compounds are among the most potent plant-derived protein kinase inhibitors yet found.
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Department of Biochemistry, La Trobe University, Bundoora, Victoria, Australia.
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D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D001921:Brain / Q000201:enzymology; D002392:Catechin / Q000494:pharmacology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000037:antagonists & inhibitors; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D008969:Molecular Sequence Data; D015394:Molecular Structure; D009219:Myosin-Light-Chain Kinase / Q000037:antagonists & inhibitors; D010944:Plants / Q000737:chemistry*; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D016392:Proto-Oncogene Proteins pp60(c-src) / Q000378:metabolism; D051381:Rats; D015398:Signal Transduction; D014908:Triticum / Q000201:enzymology; D017871:Calcium-Calmodulin-Dependent Protein Kinases
D002392:Catechin; D017868:Cyclic AMP-Dependent Protein Kinases; D005419:Flavonoids; D009219:Myosin-Light-Chain Kinase; D047428:Protein Kinase Inhibitors; D011494:Protein Kinases; D016392:Proto-Oncogene Proteins pp60(c-src); D017871:Calcium-Calmodulin-Dependent Protein Kinases