[Pattern of expression of integrins in alveolar epithelia of fetal and adult lungs and interstitial lung diseases].
We studied the expression of integrin alpha and beta chains on alveolar epithelia in normal and fibrotic lung tissue by immunohistochemistry. Alveolar epithelia and their precursor cells in fetal lung tissue consistently expressed alpha 1, alpha 2, alpha v and beta 1 chains. Neoexpression of alpha 4, alpha 6 and beta 4 chains was detected on alveolar epithelia of fibrotic lung tissue. Adhesion blocking assays with isolated type II pneumocytes were performed to investigate the substrate specificity of the alpha chains. alpha 1, alpha 2 and alpha 3 demonstrated a specificity for collagen, alpha 4, alpha 5 and alpha 6 for fibronectin, alpha 3 and alpha 6 for laminin and finally alpha 5 and alpha v for vitronectin.
Papadopoulos
T
T
Pathologisches Institut der Universität Würzburg.
Sirtl
K
K
Dämmrich
J
J
Müller-Hermelink
H K
HK
D000328:Adult; D004847:Epithelial Cells; D004848:Epithelium / Q000473:pathology; D005333:Fetus; D005455:Fluorescent Antibody Technique; D005865:Gestational Age; D006801:Humans; D007150:Immunohistochemistry; D016023:Integrins / Q000032:analysis* / Q000096:biosynthesis; D011650:Pulmonary Alveoli / Q000166:cytology* / Q000196:embryology / Q000473:pathology*; D011658:Pulmonary Fibrosis / Q000473:pathology*
D016023:Integrins