[Change in the functional activity of the blood complement system after administration of adrenaline to animals].
Epinephrine given to non-inbred male albino rats in a pharmacological dose of 1 mg/kg was studied for effects on their serum complement. Following 5 min of its administration, the complement activity both of blood overall and individual parameters reduced by 0.4-0.7 log2 as compared with the baseline, 20 minutes after it significantly increased up to 0.5 log 2 as compared with the baseline titer, and returned to the baseline level 2 hours later. Following 24 hours of epinephrine administration, complement activity again increased, by reaching its peak on days 2 and 3 of the experiment and accounting for 1.5-2.0 log2 as compared with the baseline titer. The alpha-adrenoblocker tropaphen did not affect the epinephrine-induced suppression of complement activity 5 minutes after its use and enhanced the mediated effect of the complement activity growth-associated hormone on days 2 and 3 of the experiment. Blockade with the beta-adrenoreceptor inderal virtually failed to affect the complement-mediated action on epinephrine on days 2 and 3 of its use.
Vasin
M V
MV
Kuznetsova
L N
LN
D000818:Animals; D003165:Complement System Proteins / Q000502:physiology*; D004837:Epinephrine / Q000494:pharmacology*; D005069:Evaluation Studies as Topic; D008297:Male; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000502:physiology*; D011943:Receptors, Adrenergic, beta / Q000502:physiology*
D011942:Receptors, Adrenergic, alpha; D011943:Receptors, Adrenergic, beta; D003165:Complement System Proteins; D004837:Epinephrine