title: [Agranulocytosis induced by synthetic antithyroid drugs: efficacy of hematopoietic growth factors].
abstract: Agranulocytosis is the most serious problem, potentially fatal, that can occur during antithyroid drug therapy. The use of hematopoietic growth factors is an attractive approach to reduce the period of this drug-induced neutropenia. We report two cases of severe antithyroid drug-related agranulocytosis (granulocyte count < 0.1 x 10(9)/L) treated with Granulocyte Colony-Stimulating Factor (G-CSF) or Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF). The delay to observe a granulocyte count superior to 1 x 10(9)/L was respectively 1 and 5 days. Our results, with others, clearly show that hematopoietic growth factors are effective in severe antithyroid drug-induced agranulocytosis.
authors.affiliation: Service d'Hématologie, Hôpital Victor Dupouy, Argenteuil.
authors.forename: P
authors.initials: P
authors.lastname: Genet
authors.forename: M
authors.initials: M
authors.lastname: Pulik
authors.forename: F
authors.initials: F
authors.lastname: Lionnet
authors.forename: C
authors.initials: C
authors.lastname: Bremont
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000380:Agranulocytosis / Q000139:chemically induced* / Q000188:drug therapy*; D013956:Antithyroid Agents / Q000009:adverse effects*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006728:Hormones / Q000009:adverse effects*; D006801:Humans
chemical_list: D013956:Antithyroid Agents; D006728:Hormones; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor