Comparison between transforming growth factor alpha and epidermal growth factor in the protection of rat gastric mucosa against drug-induced injury.
This study was designed to compare the protective effect of recombinant human TGF alpha or EGF against drug-induced damage to the rat gastric mucosa. Parenteral administration of TGF alpha and EGF prevented 100% ethanol-induced mucosal injury to a similar extent. Furthermore, both peptides, in non-antisecretory doses, significantly decreased the gastric mucosal damage brought about by acidified aspirin. TGF alpha and EGF did not afford significant protection of the gastric mucosa when administered orogastrically. We also evaluated the effect of TGF alpha and EGF on insoluble (adherent) gastric mucin and found that both compounds dose-dependently stimulated adherent mucin in a time frame consistent with their protective effect. In conclusion, TGF alpha and EGF are equally effective in preventing drug-induced injury to the rat gastric mucosa.
Romano
M
M
Veterans Affairs Medical Center, Nashville, Tennessee.
Kraus
E R
ER
Boland
C R
CR
Coffey
R J
RJ
D000818:Animals; D001241:Aspirin / Q000633:toxicity; D004815:Epidermal Growth Factor / Q000494:pharmacology*; D000431:Ethanol / Q000633:toxicity; D005744:Gastric Acid / Q000378:metabolism; D005752:Gastric Mucins / Q000378:metabolism; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011994:Recombinant Proteins / Q000494:pharmacology; D016211:Transforming Growth Factor alpha / Q000494:pharmacology*
D005752:Gastric Mucins; D011994:Recombinant Proteins; D016211:Transforming Growth Factor alpha; D000431:Ethanol; D004815:Epidermal Growth Factor; D001241:Aspirin