title: Genetic linkage of proteolipid protein (PLP) and thyroxine-binding globulin (TBG) on the ovine X chromosome.
abstract: Restriction fragment length polymorphisms (RFLPs) demonstrating X-linked inheritance have been identified for proteolipid protein (PLP) and thyroxine-binding globulin (TBG) in sheep. Genetic linkage between ovine PLP and TBG was examined in a three-generation flock containing 122 individuals. Significant linkage between the loci was observed with a combined lod score of 7.48 at a recombination fraction of 5 cM.
authors.affiliation: Department of Biochemistry, University of Otago, Dunedin, New Zealand.
authors.forename: J A
authors.initials: JA
authors.lastname: Sise
authors.forename: V
authors.initials: V
authors.lastname: Hanrahan
authors.forename: G W
authors.initials: GW
authors.lastname: Montgomery
authors.forename: D F
authors.initials: DF
authors.lastname: Hill
mesh_terms: D000483:Alleles; D000818:Animals; D004247:DNA / Q000097:blood / Q000302:isolation & purification; D005260:Female; D005787:Gene Frequency; D008040:Genetic Linkage; D008297:Male; D009185:Myelin Proteins / Q000235:genetics*; D018991:Myelin Proteolipid Protein; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D012756:Sheep / Q000235:genetics*; D013975:Thyroxine-Binding Proteins / Q000235:genetics*; D014960:X Chromosome
chemical_list: D009185:Myelin Proteins; D018991:Myelin Proteolipid Protein; D013975:Thyroxine-Binding Proteins; D004247:DNA