Developmental studies on vasoactive intestinal peptide, substance P and calcitonin gene-related peptide in salivary glands of postnatal rats.
The development of vasoactive intestinal peptide, substance P and calcitonin gene-related peptide in parotid, submandibular and sublingual glands of the male rat was followed by immunochemistry and immunocytochemistry. The total amounts of these peptides increased in surges during the first 8 weeks of the animal's life; one within 2-4 weeks and the other beginning 1-2 weeks later. Nerve fibres containing these peptides were present at birth showing a pattern of distribution similar to that in adults. During the first 4 weeks the nerve fibres increased in number.
Ekström
J
J
Department of Pharmacology, University of Göteborg, Sweden.
Ekman
R
R
Håkanson
R
R
Luts
A
A
Sundler
F
F
D000818:Animals; D000831:Animals, Newborn; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D008297:Male; D009412:Nerve Fibers / Q000737:chemistry; D010306:Parotid Gland / Q000737:chemistry / Q000254:growth & development / Q000294:innervation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012469:Salivary Glands / Q000737:chemistry*; D013361:Sublingual Gland / Q000737:chemistry / Q000254:growth & development / Q000294:innervation; D013363:Submandibular Gland / Q000737:chemistry / Q000254:growth & development / Q000294:innervation; D013373:Substance P / Q000032:analysis*; D014660:Vasoactive Intestinal Peptide / Q000032:analysis*
D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D015740:Calcitonin Gene-Related Peptide