title: Extrinsic denervation increases NADPH diaphorase staining in myenteric nerves of guinea pig ileum.
abstract: The number of nicotinamide adenine dinucleotide phosphate diaphorase (NADPH-d)-positive cells in the myenteric plexus increased 1 week after surgical extrinsic denervation of a loop of guinea pig ileum. NADPH-d staining in submucosal ganglia and vasoactive intestinal polypeptide immunoreactivity in submucosal and myenteric ganglia were not affected by denervation. Similar data were obtained after systemic capsaicin, but not 6-hydroxy-dopamine treatment, suggesting that loss of primary afferents increases NADPH-d staining. Increases in NADPH-d may be part of an adaptive process allowing normal gut function after loss of extrinsic nerves.
authors.affiliation: Department of Pharmacology and Toxicology, Michigan State University, East Lansing 48824.
authors.forename: A M
authors.initials: AM
authors.lastname: Yunker
authors.forename: J J
authors.initials: JJ
authors.lastname: Galligan
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D002211:Capsaicin / Q000494:pharmacology; D003714:Denervation; D006168:Guinea Pigs; D007082:Ileum / Q000294:innervation*; D008297:Male; D009197:Myenteric Plexus / Q000166:cytology / Q000187:drug effects / Q000201:enzymology*; D009252:NADPH Dehydrogenase / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism; D016627:Oxidopamine / Q000494:pharmacology; D013194:Staining and Labeling; D013373:Substance P / Q000378:metabolism; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism
chemical_list: D013373:Substance P; D014660:Vasoactive Intestinal Peptide; D016627:Oxidopamine; D009252:NADPH Dehydrogenase; D015740:Calcitonin Gene-Related Peptide; D002211:Capsaicin