title: Further evaluation of transurethral laser ablation of the prostate in patients treated with anticoagulant therapy.
abstract: Transurethral Nd:YAG laser ablation of the prostate gland was used to treat benign prostatic hyperplasia (BPH) in 20 patients on Warfarin anticoagulant therapy, and in two patients with abnormal coagulation parameters secondary to haematologic disorders. Preliminary results for the first 10 of these patients has been reported previously. The mean pre-operative international normalized ratio (INR) was 2.6 (range 1.19 to 5.25) and the mean prostate volume was 56 cc (13.6-112 cc). All patients had significant subjective and objective indicators of prostatic obstruction and six patients were in urinary retention. Postoperative improvement in symptom score, maximum flow rate and post-void residual was noted in 82% of patients at 3 months, 89% at 6 months and 75% at 1 year. Two patients have required revision laser or transurethral resection of the prostate (TURP) for persistent obstruction, while one patient required revision TURP for intractable haematuria. Three patients developed haematuria requiring transfusion while four patients had mild haematuria requiring no intervention. Laser ablation of the prostate can be used successfully and safely to treat prostatic obstruction in patients with abnormal coagulation parameters, or in those who are fully anticoagulated. Anticoagulation can be maintained during surgery in this group unlike TURP where pre-operative reversal is necessary with reinstitution of therapy several days postoperatively. Other authors report at least a 50% blood transfusion rate in this group. Laser prostatectomy appears the more appealing surgical option in these patients.
authors.affiliation: Department of Urology, St Vincent's Hospital, Melbourne, Victoria, Australia.
authors.forename: T E
authors.initials: TE
authors.lastname: Kingston
authors.forename: A K
authors.initials: AK
authors.lastname: Nonnenmacher
authors.forename: H
authors.initials: H
authors.lastname: Crowe
authors.forename: A J
authors.initials: AJ
authors.lastname: Costello
authors.forename: A
authors.initials: A
authors.lastname: Street
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001777:Blood Coagulation; D006350:Heart Valve Prosthesis; D006801:Humans; D053685:Laser Therapy / Q000379:methods*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011468:Prostatectomy; D011470:Prostatic Hyperplasia / Q000601:surgery*; D011517:Prothrombin Time; D013924:Thrombophlebitis / Q000188:drug therapy; D014859:Warfarin / Q000627:therapeutic use*
chemical_list: D014859:Warfarin