t(1;19) without detectable E2A rearrangements in two t(14;18)-positive lymphoma/leukemia cases.
Translocation t(1;19)(q23;p13) plays a crucial role in the pathogenesis of childhood pre-B cell leukemia and results in the formation of a fusion gene E2A-PBX1 that encodes a hybrid transcription factor with oncogenic potential. Here we describe two cases, one follicular lymphoma and one acute lymphoblastic leukemia/lymphoma, characterized by a complex karyotype including t(14;18), t(8;14), as well as t(1;19). Molecular studies in both cases failed to show rearrangements of the E2A gene. These results suggest that the t(1;19) found as a secondary chromosome change in t(14;18)-positive lymphoma/leukemia might be a molecular variant of the t(1;19) that is typical of childhood pre-B cell leukemia.
Wlodarska
I
I
Center for Human Genetics, University of Leuven, Belgium.
Stul
M
M
De Wolf-Peeters
C
C
Verhoef
G
G
Mecucci
C
C
Cassiman
J J
JJ
Van den Berghe
H
H
D015139:Blotting, Southern; D002051:Burkitt Lymphoma / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1; D002883:Chromosomes, Human, Pair 14; D002887:Chromosomes, Human, Pair 18; D002888:Chromosomes, Human, Pair 19; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000235:genetics; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007621:Karyotyping; D016393:Lymphoma, B-Cell / Q000235:genetics*; D008224:Lymphoma, Follicular / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D051820:TCF Transcription Factors; D058125:Transcription Factor 7-Like 1 Protein; D014157:Transcription Factors; D014178:Translocation, Genetic
D004268:DNA-Binding Proteins; D051820:TCF Transcription Factors; C544912:TCF7L1 protein, human; D058125:Transcription Factor 7-Like 1 Protein; D014157:Transcription Factors