Tolerability of nimesulide and ketoprofen in paediatric patients with traumatic or surgical fractures.
The anti-inflammatory and analgesic activities of orally administered nimesulide and ketoprofen were assessed in a group of 71 paediatric patients (aged 7 to 14 years) with orthopaedic disorders. Both drugs had similar efficacy. The greatest advantage of nimesulide was its better tolerability: only 3 nimesulide-treated patients (8.6%) experienced side effects related to the drug, compared with 12 (33%) of the ketoprofen-treated children.
Facchini
R
R
Institute of Clinical Orthopaedics II, University of Milan, Italy.
Selva
G
G
Peretti
G
G
D000293:Adolescent; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002648:Child; D005260:Female; D050723:Fractures, Bone / Q000188:drug therapy*; D006801:Humans; D007660:Ketoprofen / Q000009:adverse effects / Q000627:therapeutic use*; D008297:Male; D010146:Pain / Q000188:drug therapy*; D013449:Sulfonamides / Q000009:adverse effects / Q000627:therapeutic use*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D013449:Sulfonamides; D007660:Ketoprofen; C012655:nimesulide