title: Kinetics of distribution of recirculating lymphocytes during whole body hyperthermia.
abstract: Whole body hyperthermia (WBH) not only embraces lymphocyte migration to the bone marrow and skin, but also prolongs their subsequent transit through these organs, while inhibiting homing to the lymphoid organs. The effect of WBH is transitory, it subsides within 16 h after a 8 h WBH period. The accumulation of circulating lymphocytes in lymph nodes, Payer's patches and spleen dropped significantly between 4 h and 8 h in WBH, but rose during subsequent 16 h normothermia. In the absence of the adrenal glands, the enhanced bone marrow localization observed in non-adrenalectomised rats during WBH did not occur. Skin localization increased while splenic localization fell in adrenalectomised as compared to non-adrenalectomised rats. These results strongly support the hypothesis that WBH-induced enhancement of lymphocyte migration to the bone marrow is adrenal-hormone dependent. The above mentioned changes can not be attributed to changes in blood flow to the tissues during WBH. Blood flow to the bone marrow was not significantly different from flow to this organ in normothermic rats. Flow to the skin fell significantly and yet localization in this tissue during WBH was higher than during normothermia.
authors.affiliation: Department of Surgical Research and Transplantology, Polish Academy of Sciences, Warsaw.
authors.forename: E P
authors.initials: EP
authors.lastname: Amaning
authors.forename: W L
authors.initials: WL
authors.lastname: Olszewski
mesh_terms: D000315:Adrenalectomy; D000818:Animals; D001775:Blood Circulation / Q000502:physiology*; D001833:Body Temperature Regulation / Q000502:physiology; D004912:Erythrocytes / Q000502:physiology; D006979:Hyperthermia, Induced; D007700:Kinetics; D008214:Lymphocytes / Q000502:physiology*; D008221:Lymphoid Tissue / Q000098:blood supply; D051381:Rats; D017208:Rats, Wistar