[Thrombocyte aggregation in patients with cardiac arrhythmias and effect of anti-arrhythmia agents].
Platelet aggregability was studied in 81 patients with prior myocardial infarction with various cardiac arrhythmias and its effects of some antiarrhythmic agents (allapinine, ethacizine, obsidan and cordarone). It was 32-39% higher in patients with frequent ventricular extrasystole (VE) and VE of high grades (4a and 4b by the classification of Lown and Wolt) than in control patients (without arrhythmias) and patients with supraventricular and rare VE. Ethacizine and cordarone produced a significant inhibitory effects on platelet functional activity, but the effects of allapinine and obsidan on this parameter were insignificant. There was no correlation between the magnitude of antiarrhythmic effects of the drugs and their antiaggregatory properties. It was shown that the results of examining the effects of antiarrhythmic agents on platelet aggregability in vitro were not in agreement with those obtained in vivo.
Kurbanov
R D
RD
Azimova
N A
NA
Kiakbaev
G K
GK
Abdullaev
T A
TA
Asriiants
L S
LS
Zakirov
N U
NU
Avezov
D K
DK
Faĭzullaev
B P
BP
D000157:Aconitine / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D000328:Adult; D000638:Amiodarone / Q000494:pharmacology / Q000627:therapeutic use*; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology / Q000627:therapeutic use*; D005117:Cardiac Complexes, Premature / Q000188:drug therapy* / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D010640:Phenothiazines / Q000494:pharmacology / Q000627:therapeutic use*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology / Q000627:therapeutic use*; D013617:Tachycardia, Supraventricular / Q000188:drug therapy* / Q000503:physiopathology
D000889:Anti-Arrhythmia Agents; D010640:Phenothiazines; D010975:Platelet Aggregation Inhibitors; C051402:allapinin; D011433:Propranolol; C046818:ethacizine; D000638:Amiodarone; D000157:Aconitine