title: Dose-dependent increase in the frequency of micronuclei and chromosomal aberrations by misonidazole in mouse bone marrow.
abstract: Cytogenetic effects produced in bone marrow of mice by various doses of misonidazole (MISO, 100 to 1000 mg/kg bodyweight) were studied by assaying the induction of micronuclei (MN) and chromosomal aberrations. Misonidazole increased the frequency of both micronuclei and chromosomal aberrations over normal at 24 h after treatment, however, the values were statistically significant from normal only at drug doses above 250 mg/kg. The increase was proportional to the drug dose with a best fit to linear quadratic model for MN induction. For chromosomal aberrations the data fitted equally well to linear as well as linear quadratic models.
authors.affiliation: Department of Radiobiology, Kasturba Medical College, Manipal, Karnataka, India.
authors.forename: K S
authors.initials: KS
authors.lastname: Bisht
authors.forename: P U
authors.initials: PU
authors.lastname: Devi
mesh_terms: D000818:Animals; D001853:Bone Marrow / Q000187:drug effects; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D048629:Micronuclei, Chromosome-Defective; D008920:Misonidazole / Q000633:toxicity*
chemical_list: D008920:Misonidazole