Systemic administration of 2-chloro-2'-deoxyadenosine (2-CdA) in patients with systemic scleroderma.
Three patients with diffuse variety of systemic scleroderma were treated with 2-chloro-2'-deoxyadenosine. In two of them a moderate improvement of skin involvement was observed. No significant effects of the drug on the immunological parameters have been found.
Majewski
S
S
Department of Dermatology, Medical Academy, Warsaw, Poland.
Skopińska
M
M
Błaszczyk
M
M
Ryba
M
M
Grieb
P
P
Chorzelski
T
T
Jabłońska
S
S
D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D017338:Cladribine / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D012595:Scleroderma, Systemic / Q000188:drug therapy* / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000187:drug effects
D007166:Immunosuppressive Agents; D017338:Cladribine