Can wound healing be a paradigm for tissue repair?
This paper is written in the hope, if not the conviction, that it will be helpful to investigators of muscle physiology and development. Its thesis is that cell growth, connective tissue matrix deposition, and angiogenesis are stimulated in wounds in response to NAD+ depletion caused by a burst in lactate generation. We surmise that muscle development may also involve this metabolic control.
Hunt
T K
TK
Department of Surgery and Restorative Dentistry, University of California, San Francisco 94143.
Hussain
M Z
MZ
D000246:Adenosine Diphosphate Ribose / Q000096:biosynthesis; D000818:Animals; D003094:Collagen / Q000096:biosynthesis; D005081:Exercise Therapy; D006801:Humans; D007773:Lactates / Q000096:biosynthesis; D008954:Models, Biological; D009132:Muscles / Q000293:injuries / Q000502:physiology; D009243:NAD / Q000096:biosynthesis; D009389:Neovascularization, Pathologic; D011817:Rabbits; D014945:Wound Healing / Q000502:physiology*
D007773:Lactates; D009243:NAD; D000246:Adenosine Diphosphate Ribose; D003094:Collagen