title: Acute administration of angiotensin II improves long-term habituation in the crab Chasmagnathus.
abstract: A shadow moving overhead acts as a danger stimulus and elicits an escape response in the crab Chasmagnathus granulatus that habituates after 15 trials and for a long period. A shorter training of ten trials fails to induce long-term habituation; however, a good retention of the habituated response is manifest after a 24-h interval when angiotensin II (AII) (10(-6) M, 3 ng/g) is injected post-training. By contrast, no amnestic effect of AII was found even though high doses were administered. The facilitatory effect of AII is suppressed by saralasin (10(-7) M, 0.3 ng/g), a specific angiotensin II receptor antagonist. Results are considered as suggesting that angiotensin on memory processes might have emerged early in evolution.
authors.affiliation: Facultad de Ciencias Exactas y Naturales, Depto Biología, Universidad de Buenos Aires (1428), Argentina.
authors.forename: A
authors.initials: A
authors.lastname: Delorenzi
authors.forename: M E
authors.initials: ME
authors.lastname: Pedreira
authors.forename: A
authors.initials: A
authors.lastname: Romano
authors.forename: C J
authors.initials: CJ
authors.lastname: Pirola
authors.forename: V E
authors.initials: VE
authors.lastname: Nahmod
authors.forename: H
authors.initials: H
authors.lastname: Maldonado
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D057911:Angiotensin Receptor Antagonists; D000818:Animals; D003386:Brachyura / Q000187:drug effects*; D006185:Habituation, Psychophysiologic / Q000187:drug effects*; D012153:Retention, Psychology / Q000187:drug effects; D012504:Saralasin / Q000494:pharmacology; D013997:Time Factors
chemical_list: D057911:Angiotensin Receptor Antagonists; D000804:Angiotensin II; D012504:Saralasin