Species differences in mammalian renal function: 5-HIAA, a reported marker of tubular secretion in humans, is handled exclusively by filtration in the rat.
Renal clearance of endogenous 5-HIAA has been shown to be similar to that of PAH in humans. The present study compared 5-HIAA and PAH clearances in rats. It showed that the clearance of 5-HIAA in rats was identical to that of inulin and creatinine. This suggests that in this species, 5-HIAA is only filtered and not secreted by the tubules in contrast to what is observed in humans.
Burtin
M
M
INSERM U192, Hôpital des Enfants-Malades, Paris, France.
Elghozi
J L
JL
Laude
D
D
Kleinknecht
C
C
D000818:Animals; D015415:Biomarkers; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000097:blood / Q000493:pharmacokinetics*; D007668:Kidney / Q000378:metabolism*; D007684:Kidney Tubules / Q000378:metabolism; D008297:Male; D008657:Metabolic Clearance Rate; D051381:Rats; D017207:Rats, Sprague-Dawley; D012079:Renal Circulation / Q000502:physiology; D013045:Species Specificity; D010130:p-Aminohippuric Acid / Q000097:blood / Q000493:pharmacokinetics
D015415:Biomarkers; D006897:Hydroxyindoleacetic Acid; D010130:p-Aminohippuric Acid