Identification of glioma-associated antigen MUC 2-63 as CD44.
Monoclonal antibody MUC 2-63 recognises neurogenic tumours and has been used successfully for radioimaging human malignant gliomas. We now show that the MUC 2-63 antigen has the same tissue distribution and molecular weight range as the CD44 antigen and confirm the identity of these two molecules in blocking studies using MUC 2-63 and the CD44 anti-framework antibody F10-44-2. Thus not only MUC 2-63 but also other anti-CD44 monoclonal antibodies should prove useful in imaging and, perhaps, therapy of brain tumours.
Romeijn
P
P
Department of Immunology, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Lenthall
R
R
Stavrou
D
D
Melcher
D
D
Ladyman
H
H
Ritter
M A
MA
D000906:Antibodies / Q000276:immunology; D000918:Antibody Specificity; D000951:Antigens, Neoplasm / Q000032:analysis* / Q000276:immunology; D015153:Blotting, Western; D002352:Carrier Proteins / Q000032:analysis* / Q000276:immunology; D003106:Colon / Q000737:chemistry; D005434:Flow Cytometry; D005910:Glioma / Q000737:chemistry*; D006801:Humans; D018960:Hyaluronan Receptors; D007150:Immunohistochemistry; D008970:Molecular Weight; D011956:Receptors, Cell Surface / Q000032:analysis* / Q000276:immunology; D016201:Receptors, Lymphocyte Homing / Q000032:analysis* / Q000276:immunology; D012867:Skin / Q000737:chemistry; D013950:Thymus Gland / Q000737:chemistry
D000906:Antibodies; D000951:Antigens, Neoplasm; D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D011956:Receptors, Cell Surface; D016201:Receptors, Lymphocyte Homing