[Use of proteolytic enzyme inhibitors for stabilizing medicinal substances during storage].
The possibility of stabilizing medicinal preparations of protein nature using the inhibitor of proteolytic enzymes, contrical (Trasilol) has been studied. On long storage, free ammonia and products of protein fragmentation accumulated in protein preparations, and the degree of amidation was reduced. This led to the decrease in biological activity of immunoglobulins and insulin. Contrical produced a stabilizing effect irrespective of the nature of protein, and because of this may find an application in pharmacy.
Shepotinovskaia
I V
IV
Umanskaia
N Ia
NIa
Pushkina
N V
NV
D007611:Aprotinin / Q000494:pharmacology*; D004355:Drug Stability; D004356:Drug Storage; D006801:Humans; D006868:Hydrolysis; D007136:Immunoglobulins / Q000494:pharmacology
D007136:Immunoglobulins; D007611:Aprotinin