Increased production of immune activation marker neopterin by colony-stimulating factors in gynecological cancer patients.
Granulocyte colony-stimulating factor (G-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) have recently been introduced in the treatment of chemotherapy-induced neutropenia. Effects of these CSFs on the cellular immune system were evaluated in 38 neutropenic gynecological cancer patients during chemotherapy. In addition to restoring the leukocyte count, GM-CSF--to a greater extent than G-CSF--also induced neopterin, a sensitive marker of macrophages activated by interferons. This effect was confirmed in vitro by investigating the effects of these CSFs on interferon-gamma-mediated pathways in THP-I human myelomonocytic cells. The results suggest activation of immune effector cells by GM-CSF.
Marth
C
C
Department of Obstetrics and Gynecology, University Hospital, Innsbruck, Austria.
Weiss
G
G
Koza
A
A
Reibnegger
G
G
Daxenbichler
G
G
Zeimet
A G
AG
Fuchs
D
D
Wachter
H
H
Dapunt
O
O
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D014408:Biomarkers, Tumor / Q000096:biosynthesis* / Q000652:urine; D001708:Biopterins / Q000031:analogs & derivatives* / Q000096:biosynthesis / Q000652:urine; D002460:Cell Line; D005260:Female; D005833:Genital Neoplasms, Female / Q000188:drug therapy* / Q000276:immunology* / Q000378:metabolism; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D008875:Middle Aged; D019798:Neopterin
D014408:Biomarkers, Tumor; D016179:Granulocyte Colony-Stimulating Factor; D001708:Biopterins; D019798:Neopterin; D016178:Granulocyte-Macrophage Colony-Stimulating Factor