Report on the clinical effects of inadvertent radiation underdosage in 1045 patients.
Between Autumn 1982 and Winter 1991, 1045 patients received lower doses of radiation than were prescribed for the treatment of their cancers because of a miscalculation of radiation doses. This occurred as a result of the introduction of a new technique of treatment planning. An error in the application of the planning system lead to an underdosage of radiation of between 5 and 35%. In patients who received radiation alone for radical treatment a dose reduction of 20% or more resulted in a lower than expected local control rate. The effects were less marked in patients who were treated by combinations of surgery and radiation and in those with a very high rate of distant metastases. In 1991, a new computer planning system was installed and a discrepancy was discovered between the new plans and those from the previous system. Further investigation revealed that the original planning system already contained within it a correction factor for the tumour to skin distance and that systematically reapplying this correction had resulted in underdoses of radiation being delivered to patients for nearly 10 years. During the 9-year period of this dose miscalculation only 6% of patients treated in the department were treated with the isocentric technique; for many of those it formed only a part of their treatment.
Ash
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Yorkshire Regional Centre for Cancer Treatment, Cookridge Hospital, Leeds, UK.
Bates
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D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003131:Combined Modality Therapy; D016889:Endometrial Neoplasms / Q000532:radiotherapy; D004938:Esophageal Neoplasms / Q000532:radiotherapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008175:Lung Neoplasms / Q000532:radiotherapy; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control; D009369:Neoplasms / Q000532:radiotherapy* / Q000601:surgery; D010166:Palliative Care; D011471:Prostatic Neoplasms / Q000532:radiotherapy; D011830:Radiation Effects; D011879:Radiotherapy Dosage; D011880:Radiotherapy Planning, Computer-Assisted; D012004:Rectal Neoplasms / Q000532:radiotherapy; D015996:Survival Rate; D016896:Treatment Outcome; D001749:Urinary Bladder Neoplasms / Q000532:radiotherapy; D002583:Uterine Cervical Neoplasms / Q000532:radiotherapy