Increased protein tyrosine-phosphorylation in primary T-cells transduced with Tax1 of human T-cell leukemia virus type I.
Protein tyrosine-phosphorylation in primary human T-cells transduced with Tax1 of Human T-cell leukemia virus type I was investigated. In comparison with control T-cells, the level of protein tyrosine-phosphorylation after stimulation with anti-CD3 antibody increased significantly in Tax1-transduced T-cells. This enhancement in tyrosine-phosphorylation possibly accounted for the augmented proliferation response of these cells, which has been reported previously [J. Virol. 67 (1993) 1211-1217].
Akagi
T
T
Virology Division, National Cancer Center Research Institute, Tokyo, Japan.
Ono
H
H
Sasaki
T
T
Shimotohno
K
K
D002461:Cell Line, Transformed; D002478:Cells, Cultured; D016356:Gene Products, tax / Q000235:genetics / Q000378:metabolism*; D015368:Human T-lymphotropic virus 1 / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008213:Lymphocyte Activation; D010766:Phosphorylation; D019000:Phosphotyrosine; D013601:T-Lymphocytes / Q000378:metabolism / Q000821:virology*; D006377:T-Lymphocytes, Helper-Inducer / Q000378:metabolism / Q000821:virology; D014443:Tyrosine / Q000031:analogs & derivatives* / Q000378:metabolism
D016356:Gene Products, tax; D019000:Phosphotyrosine; D014443:Tyrosine