title: Clinical and biologic characteristics of CD7+ acute myeloid leukemia. Our experience and literature review.
abstract: Six patients with acute myeloid leukemia (AML) expressing CD7 antigen (CD7+ AML) were studied. They consisted of five patients with M1 and one with an M2 morphology. Two cases expressed other lymphoid-associated antigens, in addition to CD7. The complete remission rate was 50%. One patient had central nervous system recurrence. Cytogenetic analysis demonstrated normal karyotypes in all the cases. All but one had germline configurations of the T-cell receptor (TCR) genes and immunoglobulin heavy chain gene. However, all did not have detectable recombinase activating gene-1 activity by the RT-PCR technique. We performed colony formation assay in two patients, and no enhancement of colony formation by granulocyte colony-stimulating factor was noted. The results presented here, together with those reported previously, suggest that CD7+ AML may demonstrate lineage infidelity.
authors.affiliation: First Department of Internal Medicine, Tokyo Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shimamoto
authors.forename: J H
authors.initials: JH
authors.lastname: Ohyashiki
authors.forename: K
authors.initials: K
authors.lastname: Ohyashiki
authors.forename: K
authors.initials: K
authors.lastname: Kawakubo
authors.forename: Y
authors.initials: Y
authors.lastname: Inatomi
authors.forename: H
authors.initials: H
authors.lastname: Fujieda
authors.forename: S
authors.initials: S
authors.lastname: Nakazawa
authors.forename: N
authors.initials: N
authors.lastname: Kimura
authors.forename: J
authors.initials: J
authors.lastname: Miyauchi
authors.forename: K
authors.initials: K
authors.lastname: Toyama
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis*; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D001483:Base Sequence; D002648:Child; D017931:DNA Primers; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D018398:Homeodomain Proteins; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007133:Immunoglobulin Joining Region / Q000235:genetics; D016130:Immunophenotyping; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000276:immunology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D014176:Protein Biosynthesis; D011948:Receptors, Antigen, T-Cell / Q000235:genetics; D014407:Tumor Cells, Cultured
chemical_list: D015703:Antigens, CD; D019011:Antigens, CD7; D000945:Antigens, Differentiation, T-Lymphocyte; D017931:DNA Primers; D018398:Homeodomain Proteins; D007143:Immunoglobulin Heavy Chains; D007133:Immunoglobulin Joining Region; D011948:Receptors, Antigen, T-Cell; C064658:RAG-1 protein; D016179:Granulocyte Colony-Stimulating Factor