[Study for relapse cases of chronic hepatitis C treated with interferon (IFN) and approach to more successful re-treatment of IFN].
It is well known that relapse of hepatitis develops in 30 approximately 40% cases of chronic hepatitis C after treatment of IFN. We assessed the background of those cases and investigated a scheme providing more successful re-treatment of IFN for those relapse cases. Cases developing complete response to re-treatment showed as follows. (1) During first IFN therapy, ALT sustained within normal. (2) Serum HCV-RNA levels before re-treatment demonstrated significantly lower than the levels of first therapy. (3) IFN dose of re-treatment was greater than first therapy. (4) Terms of initial daily IFN administration tended to be more longer (4W) than first therapy (2W).
Iwabuchi
S
S
Second Department of Internal Medicine, St. Marianna University School of Medicine.
Yoshida
H
H
Fukui
S
S
D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D002908:Chronic Disease; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000628:therapy*; D006801:Humans; D007372:Interferons / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D012367:RNA, Viral / Q000097:blood; D012008:Recurrence; D012189:Retrospective Studies; D016896:Treatment Outcome
D012367:RNA, Viral; D007372:Interferons; D000410:Alanine Transaminase