Small gliomas: metabolism and blood flow.
Eight patients with small gliomas (6 low-grade and 2 high-grade) localized in a single gyrus or less than 2 cm diameter were investigated using positron emission tomography and single photon emission computed tomography. All three tumors examined demonstrated hypermetabolism of amino acids. High-grade gliomas demonstrated hypermetabolism of glucose and high blood flow, but normal or low oxygen metabolism. High-grade gliomas also showed accumulation of 201Tl chloride and high or low accumulation of 123I-isopropyl iodoamphetamine. These indications allow preoperative diagnosis of the malignancy of small gliomas, which is important because small gliomas with high-grade malignancy need more extensive removal and adjuvant therapy.
Tamura
M
M
Department of Neurosurgery, Gunma University School of Medicine, Maebashi.
Shibasaki
T
T
Horikoshi
S
S
Ono
N
N
Zama
A
A
Kakegawa
T
T
Ishiuchi
S
S
D000328:Adult; D001254:Astrocytoma / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D002540:Cerebral Cortex / Q000098:blood supply / Q000000981:diagnostic imaging / Q000473:pathology; D002648:Child; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D005909:Glioblastoma / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D012039:Regional Blood Flow / Q000502:physiology; D015173:Supratentorial Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000473:pathology; D014055:Tomography, Emission-Computed; D015899:Tomography, Emission-Computed, Single-Photon