[Sharing antigenic determinant of colon carcinoma between serous and mucinous tumors of the ovary].
Expression of colon-ovarian tumor antigen (COTA) in serous and mucinous tumors of the ovary was determined immunohistochemically, using monoclonal antibody SC13A against colon carcinoma antigen as a probe. In 67 serous tumor of the ovary, the frequency of expression was 90.0% in the cystadenocarcinomas, 71.4% in the borderline cystadenomas, and only 8.0% in the cystadenomas. In 44 mucinous tumors of the ovary, the SC13A marker was expressed in 87.5% of the malignant tumors, 80.0% of the borderline tumors, and 25.8% of the benign cystadenomas. And in 20 samples of normal ovarian tissue a negative immunostaining for the SC13A was found. These findings showed that the serous and the mucinous tumors share the same antigenic determinant of colon cancer, and the percentage expression of which is significantly higher in the malignant than in the benign and the borderline tumors, as well as in the normal ovarian tissues (P < 0.005). The marker might be valuable for further studies of these tumors.
Liu
M P
MP
General Hospital of PLA, Shenyang area.
Lu
Z T
ZT
Chen
W
W
D000818:Animals; D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis*; D018282:Cystadenocarcinoma, Mucinous / Q000276:immunology*; D018284:Cystadenocarcinoma, Serous / Q000276:immunology*; D000939:Epitopes; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D000939:Epitopes; C045043:colon-ovarian tumor antigen, human