title: Power spectra and cooperativity of a calcium-regulated cation channel.
abstract: In this article we show that a channel complex of cooperatively interacting subunits can produce a power law spectrum with the slope of the spectrum depending on the strength of the cooperative interaction. The effects of cooperativity are explored via a computational model of a calcium-regulated cation channel for which new data is presented. The results, which concern "flickering" conductances, are correlated with prior work on critical fluctuations in the Ising model of ferromagnetism.
authors.affiliation: PLEX Corporation, Brookline, Massachusetts 02146.
authors.forename: M W
authors.initials: MW
authors.lastname: McGeoch
authors.forename: J E
authors.initials: JE
authors.lastname: McGeoch
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology; D002118:Calcium / Q000378:metabolism* / Q000494:pharmacology; D004553:Electric Conductivity; D006321:Heart / Q000502:physiology; D015640:Ion Channel Gating; D007473:Ion Channels / Q000187:drug effects / Q000502:physiology*; D008051:Lipid Bilayers; D008433:Mathematics; D008565:Membrane Proteins / Q000187:drug effects / Q000502:physiology*; D008954:Models, Biological; D009132:Muscles / Q000502:physiology; D051381:Rats; D013574:Synaptosomes / Q000502:physiology
chemical_list: D007473:Ion Channels; D008051:Lipid Bilayers; D008565:Membrane Proteins; D002118:Calcium