Effect of Commiphora molmol (oleo-gum-resin) on the cytological and biochemical changes induced by cyclophosphamide in mice.
The anticlastogenic and biochemical potentials of Commiphora molmol were studied in Swiss albino mice treated with cyclophosphamide (CP). The C.molmol treatment (125-500 mg/kg) showed no mutagenicity. It caused a highly significant and dose-dependent mitodepressant effect in the femoral cells and reduction of RNA levels in hepatic cells as compared with the control. CP treatment showed significant increase in the frequency of micronuclei, cytotoxicity and reduction in the contents of nucleic acids and proteins. Pretreatment with C. molmol could neither alter the biochemical and cytological effects of CP nor show any additive effect of both treatments.
al-Harbi
M M
MM
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
Qureshi
S
S
Ahmed
M M
MM
Rafatullah
S
S
Shah
A H
AH
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D003520:Cyclophosphamide / Q000037:antagonists & inhibitors* / Q000633:toxicity; D004247:DNA / Q000096:biosynthesis; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008514:Medicine, Arabic; D051379:Mice; D008815:Mice, Inbred Strains; D015162:Micronucleus Tests; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D014176:Protein Biosynthesis; D012313:RNA / Q000096:biosynthesis
D016587:Antimutagenic Agents; D010936:Plant Extracts; C018620:oleoresins; D012313:RNA; D003520:Cyclophosphamide; D004247:DNA