title: Functional imaging of the human olfactory cortex by magnetic resonance imaging.
abstract: Our understanding of the neural mechanism of human olfaction is still equivocal. Several recent reports document that functional magnetic resonance imaging (MRI) has a potential to visualize dynamic brain function in humans without invasion. In the present study, we applied functional MRI with odor stimulation for the purpose of clarifying the localization of olfactory cortices in the human. We obtained a significant increase in cerebral blood flow in the piriform cortex, orbitofrontal cortex, and inferior medial frontal lobe, corresponding to olfactory cortices. These results suggest that, in the near future, precise diagnosis of the patients with olfactory disorders will be possible using functional MRI with odor stimulation.
authors.affiliation: Department of Otolaryngology, Osaka University Medical School, Suita, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Koizuka
authors.forename: H
authors.initials: H
authors.lastname: Yano
authors.forename: M
authors.initials: M
authors.lastname: Nagahara
authors.forename: R
authors.initials: R
authors.lastname: Mochizuki
authors.forename: R
authors.initials: R
authors.lastname: Seo
authors.forename: K
authors.initials: K
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: T
authors.initials: T
authors.lastname: Nogawa
mesh_terms: D000328:Adult; D002560:Cerebrovascular Circulation / Q000502:physiology; D005625:Frontal Lobe / Q000033:anatomy & histology / Q000098:blood supply / Q000502:physiology; D006801:Humans; D008279:Magnetic Resonance Imaging; D009833:Olfactory Pathways / Q000033:anatomy & histology / Q000098:blood supply / Q000502:physiology*; D010626:Phenylethyl Alcohol; D010812:Physical Stimulation; D012903:Smell / Q000502:physiology; D013382:Subtraction Technique
chemical_list: D010626:Phenylethyl Alcohol