title: Hepatitis B surface antigen, hepatitis C virus antibody, body mass index, and alcohol drinking among workers with elevated serum alanine aminotransferase.
abstract: METHODS
  We conducted a case-control study on liver diseases among Japanese workers to examine associations between elevated serum alanine aminotransferase (alanine aminotransferase value > or = 50 IU/liter) and selected factors such as hepatitis B surface antigen positive, hepatitis C virus antibody positive, body mass index, and alcohol drinking. Out of 3,738 workers (1,477 males and 2,261 females) in a supermarket chain, 91 workers with an elevated serum alanine aminotransferase value (> or = 50 IU/liter) were classified as cases and 182 workers with normal serum alanine aminotransferase value and without an episode of blood transfusion were randomly selected as controls.
  
  
  RESULTS
  Prevalence rates of hepatitis B surface antigen positive and hepatitis C virus antibody positive were 4.4 and 23.1% among the overall cases, 2.9 and 11.8% among the cases with 100 > alanine aminotransferase value > or = 50, and 8.7 and 56.5% among the cases with alanine aminotransferase value > or = 100. A logistic regression analysis was conducted. Odds ratios were 4.94 for hepatitis B surface antigen positive (P < 0.05) and 77.19 for hepatitis C virus antibody positive (P < 0.001). Odds ratios for body mass index increased with increasing body mass index values; 3.32 for 26 > body mass index > or = 24 (P < 0.01) and 5.03 for body mass index > or = 26 (P < 0.001). No increased risk was observed among regular drinkers of less than 27 g/day of ethanol (odds ratio is 0.23) or of 27-53 g/day of ethanol (odds ratio is 0.47). A slightly increased odds ratio of 1.35 was observed among regular drinkers of 54-81 g/day of ethanol, but this was not statistically significant.
  
  
  CONCLUSIONS
  Our results suggest that hepatitis C virus and high body mass index are predominant factors in elevated serum alanine aminotransferase levels among Japanese workers, while alcohol drinking is a minor factor.
authors.affiliation: Department of Hygiene, School of Medicine, Fukuoka University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Une
authors.forename: H
authors.initials: H
authors.lastname: Esaki
authors.forename: Y
authors.initials: Y
authors.lastname: Momose
authors.forename: T
authors.initials: T
authors.lastname: Ishii
authors.forename: D
authors.initials: D
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Shigematsu
authors.forename: T
authors.initials: T
authors.lastname: Inoue
authors.forename: F
authors.initials: F
authors.lastname: Hisanaga
authors.forename: K
authors.initials: K
authors.lastname: Yoshinaga
authors.forename: H
authors.initials: H
authors.lastname: Kamo
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood*; D000428:Alcohol Drinking; D000956:Antigens, Viral / Q000302:isolation & purification*; D015992:Body Mass Index; D016022:Case-Control Studies; D005260:Female; D006514:Hepatitis B Surface Antigens / Q000302:isolation & purification*; D006526:Hepatitis C / Q000276:immunology*; D018936:Hepatitis C Antigens; D006801:Humans; D008107:Liver Diseases / Q000097:blood* / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D012044:Regression Analysis
chemical_list: D000956:Antigens, Viral; D006514:Hepatitis B Surface Antigens; D018936:Hepatitis C Antigens; D000410:Alanine Transaminase