Metastatic renal carcinoma in a pediatric recipient of an adult cadaveric donor kidney.
A 15-year old male with chronic renal failure secondary to obstructive uropathy received an adult cadaveric donor kidney. Evaluation for painless macroscopic hematuria occurring 2 years after transplantation disclosed a metastatic renal cell carcinoma, which by the use of restriction fragment length polymorphism analysis was shown to be of the donor's origin. Transplant nephrectomy and cessation of immunosuppressive therapy resulted in complete regression of multiple pulmonary metastases.
Lotan
D
D
Pediatric Nephrology Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Laufer
J
J
D000293:Adolescent; D002102:Cadaver; D002292:Carcinoma, Renal Cell / Q000209:etiology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D007680:Kidney Neoplasms / Q000209:etiology*; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D012150:Polymorphism, Restriction Fragment Length; D011183:Postoperative Complications