title: Assignment of the human gene for the water channel of renal collecting duct Aquaporin 2 (AQP2) to chromosome 12 region q12-->q13.
abstract: The chromosomal localization of the gene encoding Aquaporin 2 (previously called WCH-CD), which acts as a water channel in the collecting tubules of the kidney, was determined. Southern blot hybridizations of chromosomal DNA from a panel of 25 different human-rodent hybrid cell lines assigned AQP2 to the q-arm of human chromosome 12. Additionally, in situ hybridization on R-banded metaphase chromosomes localized AQP2 to the q12-->q13 region of this chromosome.
authors.affiliation: Department of Physiology, University of Nijmegen, The Netherlands.
authors.forename: P M
authors.initials: PM
authors.lastname: Deen
authors.forename: D O
authors.initials: DO
authors.lastname: Weghuis
authors.forename: R J
authors.initials: RJ
authors.lastname: Sinke
authors.forename: A
authors.initials: A
authors.lastname: Geurts van Kessel
authors.forename: B
authors.initials: B
authors.lastname: Wieringa
authors.forename: C H
authors.initials: CH
authors.lastname: van Os
mesh_terms: D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D002871:Chromosome Banding; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D017931:DNA Primers; D006801:Humans; D007473:Ion Channels / Q000235:genetics*; D008565:Membrane Proteins / Q000235:genetics*; D016133:Polymerase Chain Reaction; D015183:Restriction Mapping
chemical_list: C496023:AQP2 protein, human; D051399:Aquaporin 2; D051403:Aquaporin 6; D020346:Aquaporins; D017931:DNA Primers; D007473:Ion Channels; D008565:Membrane Proteins