Inhibitory effect of TNP-470, a new anti-angiogenic agent, on the estrogen induced rat pituitary tumors.
An angiogenic inhibitor, TNP-470, is an analogue of fumagillin. This study reports the effects of TNP-470 and bromocriptine on the normal pituitary glands and estrogen-induced rat pituitary tumors. TNP-470 inhibited the increase of normal pituitary weight and the tumorigenesis induced by estrogen. The decreased labelling index in the pituitary cells, showed that TNP-470 may suppress the activity of cell proliferation as the result of anti-angiogenesis. Combination treatment with TNP-470 and bromocriptine was much more effective than TNP alone. These results suggest that TNP-470 is a potentially beneficial drug for pituitary tumors.
Takechi
A
A
Department of Neurosurgery, Hiroshima University School of Medicine, Japan.
Uozumi
T
T
Kawamoto
K
K
Ito
A
A
Kurisu
K
K
Sudo
K
K
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D001835:Body Weight / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003510:Cyclohexanes; D004195:Disease Models, Animal; D004965:Estrogen Antagonists / Q000494:pharmacology*; D004967:Estrogens; D005260:Female; D009376:Neoplasms, Hormone-Dependent / Q000098:blood supply* / Q000139:chemically induced / Q000188:drug therapy*; D009389:Neovascularization, Pathologic / Q000517:prevention & control*; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D009929:Organ Size / Q000187:drug effects; D010902:Pituitary Gland / Q000033:anatomy & histology / Q000166:cytology / Q000187:drug effects; D010911:Pituitary Neoplasms / Q000098:blood supply* / Q000139:chemically induced / Q000188:drug therapy*; D011388:Prolactin / Q000097:blood; D051381:Rats; D011916:Rats, Inbred F344; D012717:Sesquiterpenes / Q000494:pharmacology*
D000903:Antibiotics, Antineoplastic; D003510:Cyclohexanes; D004965:Estrogen Antagonists; D004967:Estrogens; D012717:Sesquiterpenes; D011388:Prolactin; D000077609:O-(Chloroacetylcarbamoyl)fumagillol