Myelin basic protein gene polymorphism is not associated with chronic progressive multiple sclerosis.
In the present study a tetranucleotide (TGGA)n repeat polymorphism 5' to the myelin basic protein (MBP) gene was evaluated in a group of HLA-class II-typed, chronic progressive multiple sclerosis (MS) patients. This polymorphism has been reported by others to be associated with MS. Contrary to these reports we observed similar allele frequencies in patients and controls. Our results indicate that there is no association between MS and a polymorphism 5' to the MBP gene.
Vandevyver
C
C
Department of Immunology/Biotechnology, Dr. L. Willems-Instituut at Diepenbeek, Belgium.
Stinissen
P
P
Cassiman
J J
JJ
Raus
J
J
D000483:Alleles; D001483:Base Sequence; D002908:Chronic Disease; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D008969:Molecular Sequence Data; D009103:Multiple Sclerosis / Q000235:genetics*; D004676:Myelin Basic Protein / Q000235:genetics*; D011110:Polymorphism, Genetic
D006684:HLA-DR Antigens; D004676:Myelin Basic Protein