SP- and CGRP-immunoreactive axons differ in their ability to reinnervate the skin of the rat tail.
The reinnervation of cutaneous targets was studied in the rat tail after proximal lesions of all collector nerves. The distribution of immunofluorescent nerve fibres stained for calcitonin-gene-related peptide (CGRP) and substance P (SP) was examined after 110-210 days. Targets at all sites were reinnervated by CGRP-immunoreactive (IR) fibres. However, SP-IR terminals were rare, particularly distally, despite staining within subdermal nerve trunks.
McLachlan
E M
EM
Department of Physiology and Pharmacology, University of Queensland, Australia.
Keast
J R
JR
Bauer
M
M
D000818:Animals; D001369:Axons / Q000502:physiology*; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology*; D005260:Female; D006197:Hair / Q000294:innervation; D007150:Immunohistochemistry; D008297:Male; D009409:Nerve Crush; D009416:Nerve Regeneration / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012867:Skin / Q000294:innervation*; D013373:Substance P / Q000502:physiology*; D013623:Tail
D013373:Substance P; D015740:Calcitonin Gene-Related Peptide