Attenuation of hippocampal kainic acid-induced seizures by substance P treatment.
Adult male Wistar rats (n = 21) received bilateral kainic acid lesions of their hippocampi. Over a period of 9 weeks the animals received daily IP injections of either 5 micrograms/kg or 50 micrograms/kg substance P (SP) or vehicle. Seizures provoked by the lesions were suppressed by the daily administration of the neuropeptide SP in a dose of 50 micrograms/kg for the whole period of observation. The neurokinin significantly (p < 0.01) reduced the number of seizures compared to the vehicle-treated animals.
Klapdor
K
K
Institute of Physiological Psychology I, University of Düsseldorf, Germany.
Sprick
U
U
Huston
J P
JP
D000818:Animals; D016332:Fetal Tissue Transplantation; D006624:Hippocampus / Q000187:drug effects*; D007608:Kainic Acid / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000188:drug therapy*; D013373:Substance P / Q000627:therapeutic use*
D013373:Substance P; D007608:Kainic Acid