Heterogeneity in the plasma levels of two acute-phase proteins in mice from inbred strains infected with Trypanosoma cruzi.
We analyzed the variations observed in the plasma levels of both alpha-macroglobulins (AM) and serum amyloid P (SAP) in mice from three different inbred strains (C3H, Balb/C and C57black/6) acutely infected with Trypanosoma cruzi. SAP levels increased in C57black/6 and Balb/C mice but not C3H mice. AM levels increased in all C3H mice but not in C57black/6 mice and rose slightly in only 43% of the Balb/C mice. AM and SAP levels are differently modulated in patterns that may be strain-determined.
Luz
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MR
Department of Ultrastructure and Cell Biology, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brasil.
van Leuven
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Araújo-Jorge
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TC
D000818:Animals; D001774:Blood Chemical Analysis; D014355:Chagas Disease / Q000276:immunology* / Q000401:mortality; D014644:Genetic Variation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C / Q000276:immunology; D008809:Mice, Inbred C3H / Q000276:immunology; D008810:Mice, Inbred C57BL / Q000276:immunology; D008815:Mice, Inbred Strains / Q000276:immunology*; D000683:Serum Amyloid P-Component / Q000032:analysis*; D013997:Time Factors; D000511:alpha-Macroglobulins / Q000032:analysis*
D000683:Serum Amyloid P-Component; D000511:alpha-Macroglobulins