title: Importance of parallel vectors and "hydrophobic collapse" of the aligned aromatic rings: discovery of a potent substance P antagonist.
authors.affiliation: Central Research Division, Pfizer Inc., Groton, Connecticut 06340.
authors.forename: M C
authors.initials: MC
authors.lastname: Desai
authors.forename: L A
authors.initials: LA
authors.lastname: Vincent
authors.forename: J P
authors.initials: JP
authors.lastname: Rizzi
mesh_terms: D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D010880:Piperidines / Q000737:chemistry* / Q000378:metabolism; D018040:Receptors, Neurokinin-1 / Q000378:metabolism; D013329:Structure-Activity Relationship; D013373:Substance P / Q000037:antagonists & inhibitors*
chemical_list: D010880:Piperidines; D018040:Receptors, Neurokinin-1; C080755:3-(2-methoxybenzylamino)-2-phenylpiperidine; D013373:Substance P