Mantle cell lymphoma with the features of mucosa-associated lymphoid tissue (MALT) lymphoma in an HTLV-I-seropositive patient.
A case of small lymphocytic B-cell lymphoma with seropositivity for human T-cell leukemia virus type I (HTLV-I), whose clinical features were closely related to those of mucosa-associated lymphoid tissue (MALT) lymphoma, is presented. The neoplastic cells of the lymph node were immunologically positive for CD5, in addition to several B-cell markers, but negative for CD10, and cytogenetically carried a t(11;14)(q13;q32). These findings were fully consistent with so-called mantle cell lymphoma (MCL). In addition to the lymph nodes and bone marrow, multiple extranodal sites including lacrimal and salivary glands, lung and stomach (where MALT is present) were occupied by lymphoma cells. These extranodal lesions were immunologically identical to the lymph nodes (CD5(+), CD10(-)), but histologically showed lymphoepithelial lesions (LEL) characteristic of MALT lymphoma. These findings suggest a possible relationship between MCL and MALT lymphoma, and the neoplastic cells are thought to originate from the CD5-positive B cells, which are present near the areas across the mantle and marginal zones. Furthermore, HTLV-I-infection, which appears to create an immunodeficient state or modulate the B-cell response, is thought to play a role in B-cell lymphomagenesis.
Shibata
K
K
Department of Internal Medicine, Saga Medical School, Japan.
Shimamoto
Y
Y
Nakano
S
S
Miyahara
M
M
Nakano
H
H
Yamaguchi
M
M
D015703:Antigens, CD / Q000032:analysis; D018956:CD5 Antigens; D015481:HTLV-I Antibodies / Q000097:blood; D015490:HTLV-I Infections / Q000150:complications / Q000276:immunology / Q000473:pathology*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D018442:Lymphoma, B-Cell, Marginal Zone / Q000150:complications / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D008228:Lymphoma, Non-Hodgkin / Q000150:complications / Q000276:immunology / Q000473:pathology* / Q000821:virology*; D008297:Male; D008875:Middle Aged; D015260:Neprilysin / Q000032:analysis
D015703:Antigens, CD; D018956:CD5 Antigens; D015481:HTLV-I Antibodies; D015260:Neprilysin