High-level quinolone resistance in Neisseria gonorrhoeae: a report of two cases.
OBJECTIVE
Fluoroquinolones are widely used oral agents for treating Neisseria gonorrhoeae. Resistance to these agents is sporadic and usually at a low level. Two instances of high-dose ciprofloxacin regimens failing in the treatment of gonococcal infection, caused by strains with high-level quinolone resistance, are reported.


METHODS
This is a case report.


CONCLUSIONS
High-level resistance to quinolone antibiotics resulting in treatment failure was observed in two distinct gonococcal isolates from patients infected in the Philippines (ciprofloxacin; minimal inhibitory contribution = 16 mg/l). Continued monitoring of the quinolone sensitivity of Neisseria gonorrhoeae is appropriate and prudent.
Tapsall
J W
JW
Microbiology Department, Prince of Wales Hospital, Sydney, Australia.
Limnios
E A
EA
Thacker
C
C
Donovan
B
B
Lynch
S D
SD
Kirby
L J
LJ
Wise
K A
KA
Carmody
C J
CJ
D042462:4-Quinolones; D000328:Adult; D000890:Anti-Infective Agents / Q000627:therapeutic use*; D004352:Drug Resistance, Microbial; D024841:Fluoroquinolones; D006069:Gonorrhea / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008826:Microbial Sensitivity Tests
D042462:4-Quinolones; D000890:Anti-Infective Agents; D024841:Fluoroquinolones