Effect of human galanin on growth hormone prolactin, and antidiuretic hormone secretion in normal men.
Galanin is a brain-gut peptide occurring widely in the central and peripheral nervous system. Effects of iv administration of synthetic human galanin on pituitary GH, PRL, and antidiuretic hormone secretion were studied. Intravenous infusion of the peptide resulted in a significant increase in plasma GH levels whereas PRL and antidiuretic hormone did not significantly change. These findings suggest that galanin might play a role in modulating GH secretion in humans.
Murakami
Y
Y
Clinic of Endocrine Diseases, Shizuoka City Hospital, Japan.
Ohshima
K
K
Mochizuki
T
T
Yanaihara
N
N
D000328:Adult; D019004:Galanin; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009479:Neuropeptides / Q000494:pharmacology; D010455:Peptides / Q000009:adverse effects / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D012016:Reference Values; D014667:Vasopressins / Q000097:blood / Q000378:metabolism*
D009479:Neuropeptides; D010455:Peptides; D014667:Vasopressins; D019004:Galanin; D011388:Prolactin; D013006:Growth Hormone