Presumed central nervous system Whipple's disease in a child: case report.
Whipple's disease is a rare, chronic, multisystem illness that is pathologically characterized by the accumulation of macrophages in the involved tissue that have a positive periodic acid-Schiff reaction. It is typically seen in middle-aged white men, and only four cases involving persons younger than 15 years of age have been reported. CNS Whipple's disease without intestinal manifestations is rare; only six cases have been reported in the literature, all involving adults. We report the case of a young boy with clinical, laboratory, radiographic, and pathological signs and symptoms consistent with CNS Whipple's disease who responded to therapy with trimethoprimsulfamethoxazole.
Tan
T Q
TQ
Department of Pediatrics, Baylor College of Medicine, Houston, Texas, USA.
Vogel
H
H
Tharp
B R
BR
Carrol
C L
CL
Kaplan
S L
SL
D001927:Brain Diseases / Q000175:diagnosis / Q000188:drug therapy; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008061:Whipple Disease / Q000175:diagnosis / Q000188:drug therapy