Identification of a graft versus host disease-associated human minor histocompatibility antigen.
Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor histocompatibility antigen HA-2 was previously isolated from a patient with severe GVHD after HLA-identical bone marrow transplantation. The HLA-A2.1-bound peptide representing HA-2 has now been identified. This peptide appears to originate from a member of the non-filament-forming class I myosin family. Because HA-2 has a phenotype frequency of 95 percent in the HLA-A2.1-positive population, it is a candidate for immunotherapeutic intervention in bone marrow transplantation.
den Haan
J M
JM
Department of Immunohaematology, University Hospital, Leiden, Netherlands.
Sherman
N E
NE
Blokland
E
E
Huczko
E
E
Koning
F
F
Drijfhout
J W
JW
Skipper
J
J
Shabanowitz
J
J
Hunt
D F
DF
Engelhard
V H
VH
D000595:Amino Acid Sequence; D016026:Bone Marrow Transplantation; D000939:Epitopes; D005260:Female; D006086:Graft vs Host Disease / Q000276:immunology*; D015789:HLA-A2 Antigen / Q000276:immunology; D006801:Humans; D013058:Mass Spectrometry; D015778:Minor Histocompatibility Antigens / Q000737:chemistry / Q000276:immunology*; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000737:chemistry / Q000276:immunology*; D009842:Oligopeptides / Q000737:chemistry / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology
D000939:Epitopes; C080145:HA-2 antigen; D015789:HLA-A2 Antigen; D015778:Minor Histocompatibility Antigens; D009363:Neoplasm Proteins; D009842:Oligopeptides