[Elevated p53 protein expression in normal and neoplastic light-exposed epidermis].
p53 protein levels are frequently elevated in basal (BCC) and squamous (SCC) cell carcinomas of UV-exposed sites. As recent findings in benign epidermal neoplasia (BEN) and normal epidermis (NE) are controversial, our aim was to look by immunohistochemistry for elevated p53 levels in NE (n = 52), reactive hyperplastic epidermis (REH, n = 8), BEN (n = 48), actinic keratosis (AK, n = 60), SCC (n = 13), and BCC (n = 42) of sun-exposed sites. 81.7% of AK, 100% of SCC, 73.8% of BCC as well as 29.2% of BEN, 37.5% of REH, and 26.9% of NE showed p53 positivity. The results further support that p53 elevated levels are an early marker of UV-mediated epidermal DNA damage.
Sutter
C
C
Abteilung für Umweltpathologie, Heinrich-Heine-Universität Düsseldorf.
Wersin
R
R
Varnai
M
M
Friemann
J
J
D002280:Basal Cell Carcinoma / Q000378:metabolism / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000378:metabolism / Q000473:pathology; D000078404:Epidermal Cells; D004817:Epidermis / Q000378:metabolism* / Q000528:radiation effects; D015870:Gene Expression; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D007642:Keratosis / Q000378:metabolism / Q000473:pathology; D012867:Skin / Q000166:cytology* / Q000378:metabolism* / Q000528:radiation effects; D012878:Skin Neoplasms / Q000378:metabolism / Q000473:pathology*; D013472:Sunlight; D016159:Tumor Suppressor Protein p53 / Q000032:analysis / Q000096:biosynthesis*
D016159:Tumor Suppressor Protein p53