Mapping of the gene for the Mel1a-melatonin receptor to human chromosome 4 (MTNR1A) and mouse chromosome 8 (Mtnr1a).
The pineal hormone melatonin elicits potent circadian and reproductive effects in mammals. We report the chromosomal location of the gene for the Mel1a-melatonin receptor that likely mediates these circadian and reproductive actions. PCR analysis of human-rodent somatic cell hybrids showed that the receptor gene (MTNR1A) maps to human chromosome 4q35.1. An interspecific backcross analysis revealed that the mouse gene (Mtnr1a) maps to the proximal portion of chromosome 8. These loci may be involved in genetically based circadian and neuroendocrine disorders.
Slaugenhaupt
S A
SA
Molecular Neurogenetics Unit, Massachusetts General Hospital, Boston 02114, USA.
Roca
A L
AL
Liebert
C B
CB
Altherr
M R
MR
Gusella
J F
JF
Reppert
S M
SM
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002875:Chromosomes; D002894:Chromosomes, Human, Pair 4; D002940:Circadian Rhythm / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D008969:Molecular Sequence Data; D011956:Receptors, Cell Surface / Q000235:genetics*; D044094:Receptors, Melatonin
D011956:Receptors, Cell Surface; D044094:Receptors, Melatonin