title: Osteoporosis in severe congenital neutropenia treated with granulocyte colony-stimulating factor.
abstract: Recombinant human granulocyte colony-stimulating factor (G-CSF) has substantially improved life expectancy for children with severe congenital neutropenia (SCN). Severe osteoporosis, reported in this population, may relate to the disease process, or be a therapeutic side-effect. This report details bone loss, quantitated absorptiometrically and histomorphometrically, in a child with SCN and vertebral collapse, and the positive response to anabolic steroid and bisphosphonate therapy.
authors.affiliation: Department of Paediatrics, Addenbrooke's Hospital, Cambridge.
authors.forename: N J
authors.initials: NJ
authors.lastname: Bishop
authors.forename: D M
authors.initials: DM
authors.lastname: Williams
authors.forename: J C
authors.initials: JC
authors.lastname: Compston
authors.forename: D M
authors.initials: DM
authors.lastname: Stirling
authors.forename: A
authors.initials: A
authors.lastname: Prentice
mesh_terms: D045930:Anabolic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D009503:Neutropenia / Q000151:congenital* / Q000628:therapy; D010024:Osteoporosis / Q000209:etiology*; D011994:Recombinant Proteins / Q000009:adverse effects
chemical_list: D045930:Anabolic Agents; D004164:Diphosphonates; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor