The role of stem cell factor in mobilization of peripheral blood progenitor cells.
Stem cell factor (SCF) is a hematopoietic growth factor which acts on both primitive and mature progenitors cells. In animals, high doses of SCF alone stimulate increases in cells of multiple lineages and mobilize peripheral blood progenitor cells (PBPC). Phase I studies of rhSCF have demonstrated dose related side effects which are consistent with mast cell activation. Based upon in vitro synergy between SCF and G-CSF we have demonstrated the potential of low doses of SCF to synergize with G-CSF to give enhanced mobilization of PBPC. These PBPC have increased potential for both short and long term engraftment in lethally irradiated mice and lead to more rapid recovery of platelets. On going Phase I/II studies with rhSCF plus rhG-CSF for mobilization of PBPC, demonstrated similar increases in PBPC compared to rhG-CSF alone. These data suggest a clinical role of rhSCF in combination with rhG-CSF for optimal mobilization of PBPC.
McNiece
I K
IK
Department of Developmental Hematology, Amgen Inc., Thousand Oaks, California 91320-1789.
Briddell
R A
RA
Yan
X Q
XQ
Hartley
C A
CA
Gringeri
A
A
Foote
M A
MA
Andrews
R G
RG
D000818:Animals; D003115:Colony-Stimulating Factors / Q000008:administration & dosage; D016298:Hematopoietic Cell Growth Factors / Q000494:pharmacology*; D006412:Hematopoietic Stem Cells / Q000187:drug effects*; D007937:Leukapheresis; D051379:Mice; D010215:Papio; D011994:Recombinant Proteins / Q000494:pharmacology; D019089:Stem Cell Factor
D003115:Colony-Stimulating Factors; D016298:Hematopoietic Cell Growth Factors; D011994:Recombinant Proteins; D019089:Stem Cell Factor