title: Turnover of circulating virion RNA and of cell-associated viral DNA reflects active viral replication in human immunodeficiency virus type 1-infected individuals.
abstract: A quantitative assessment of human immunodeficiency virus type 1 turnover in patient cell-free virion and infected-cell compartments under the dynamic conditions imposed by an effective antiviral therapy was performed. The turnover was rapid, and following a temporal lag, the extent of viral population replacement was eventually similar in both compartments. Each compartment therefore reflects considerable active virus replication.
authors.affiliation: Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania 19486.
authors.forename: D W
authors.initials: DW
authors.lastname: Lineberger
authors.forename: J A
authors.initials: JA
authors.lastname: Kessler
authors.forename: J A
authors.initials: JA
authors.lastname: Waterbury
authors.forename: V W
authors.initials: VW
authors.lastname: Byrnes
authors.forename: F
authors.initials: F
authors.lastname: Massari
authors.forename: S
authors.initials: S
authors.lastname: Staszewski
authors.forename: E A
authors.initials: EA
authors.lastname: Emini
mesh_terms: D000998:Antiviral Agents / Q000494:pharmacology; D001583:Benzoxazoles / Q000494:pharmacology; D002451:Cell Compartmentation; D002474:Cell-Free System; D004279:DNA, Viral / Q000378:metabolism*; D015658:HIV Infections / Q000821:virology*; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D011728:Pyridones / Q000494:pharmacology; D012367:RNA, Viral / Q000378:metabolism*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D018894:Reverse Transcriptase Inhibitors; D014771:Virion / Q000235:genetics*; D014779:Virus Replication / Q000235:genetics
chemical_list: D000998:Antiviral Agents; D001583:Benzoxazoles; D004279:DNA, Viral; D011728:Pyridones; D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; C076516:L-697661; D054303:HIV Reverse Transcriptase; D012194:RNA-Directed DNA Polymerase