Identification, characterisation, and measurement of immunoglobulin concentrations in grey (Haliocherus grypus) and common (Phoca vitulina) seals.
Concentrations of macroglobulin, total gammaglobulin, and a gammaglobulin subclass were measured in grey and common seals. In pups, immunoglobulin M (IgM) was found to rise rapidly, concentrations reaching adult values by approximately 14 days postpartum. Total IgG concentrations increased more slowly, only approaching 50% of juvenile and adult male values by 30 days after birth. Concentrations of the IgG subclass did not change significantly postpartum. Total IgG concentrations measured in adult female grey seals sampled during lactation were found to be lower than in males and juveniles. This apparent immunosuppression may be associated with pregnancy.
King
D P
DP
Division of Clinical Sciences, School of Medicine, Old Medical School, University of Leeds, UK.
Lowe
K A
KA
Hay
A W
AW
Evans
S W
SW
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D002846:Chromatography, Affinity; D000939:Epitopes / Q000276:immunology; D005260:Female; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D007136:Immunoglobulins / Q000097:blood*; D007774:Lactation / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D049590:Postpartum Period / Q000276:immunology; D046048:Seals, Earless / Q000254:growth & development / Q000276:immunology*; D013045:Species Specificity
D000911:Antibodies, Monoclonal; D000939:Epitopes; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007136:Immunoglobulins