CD23 and B-cell activation.
The past year has seen the publication of significant new findings on the regulation of CD23 expression, the precise interaction of CD23 with CD21 and its functional consequences. Moreover, new advances have been made in unravelling the biochemical network of events downstream from the triggering of CD23 in human B cells. Analyses of the properties of CD23-deficient mice have demonstrated a link between IgE regulation and CD23 in vivo.
Bonnefoy
J Y
JY
Immunology Department, Glaxo Institute for Molecular Biology, Geneva, Switzerland.
Lecoanet-Henchoz
S
S
Aubry
J P
JP
Gauchat
J F
JF
Graber
P
P
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology* / Q000502:physiology; D015815:Cell Adhesion Molecules / Q000276:immunology; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis; D008213:Lymphocyte Activation; D051379:Mice; D008822:Mice, Transgenic; D017455:Receptors, IgE / Q000276:immunology*; D015398:Signal Transduction
D015815:Cell Adhesion Molecules; D017455:Receptors, IgE; D007073:Immunoglobulin E