The effect of colchicine and vinblastine on bleomycin-induced lung fibrosis in rats.
The effect of colchicine and vinblastine on collagenase, lysyl oxidase and prolyl hydroxylase activities as well as on collagen cross-linking and types of this protein in bleomycin induced lung fibrosis in rats was investigated. Both colchicine and vinblastine diminish bleomycin-induced changes in the above-mentioned enzyme activities as well as collagen cross-linking and normalize type I/type III collagen ratio.
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Department of Pathophysiology, Veterinary Faculty of Agricultural Academy, Lublin, Poland.
D000818:Animals; D001761:Bleomycin; D003078:Colchicine / Q000494:pharmacology*; D003094:Collagen / Q000187:drug effects; D017364:Collagenases / Q000378:metabolism; D003432:Cross-Linking Reagents / Q000494:pharmacology; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000188:drug therapy*; D051381:Rats; D017208:Rats, Wistar; D014747:Vinblastine / Q000494:pharmacology*
D003432:Cross-Linking Reagents; D001761:Bleomycin; D014747:Vinblastine; D003094:Collagen; D011393:Procollagen-Proline Dioxygenase; D008249:Protein-Lysine 6-Oxidase; D017364:Collagenases; D003078:Colchicine