title: Serotonergic measures in cyclosporine A treated rats.
abstract: Whole blood and plasma serotonin (5-HT), its major metabolite--5-hydroxyindoleacetic acid (5-HIAA), renal cortical blood flow, serum creatinine and whole blood cyclosporine A (CyA) levels were investigated in rats administered with CyA at a dose of 5 mg/kg b.w. or 10 mg/kg b.w. for 14 consecutive days. Serum creatinine remained unaltered during CyA treatment and no apparent changes in excised kidneys were found. Dose-dependent increases in whole blood and plasma 5-HT as well as whole blood 5-HIAA levels were observed. Renal cortical blood flow declined significantly and correlated inversely with whole blood 5-HT and 5-HIAA as well as with plasma 5-HT. Whole blood 5-HT was positively related to whole blood CyA levels. Taking all these data into account and considering the fact that 5-HT is a potent vasoconstrictor, a possible role of this amine in the pathogenesis of renal ischemia during CyA administration is suggested.
authors.affiliation: Department of Urology, Hamamatsu University School of Medicine, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Ueda
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: J
authors.initials: J
authors.lastname: Malyszko
authors.forename: M H
authors.initials: MH
authors.lastname: Pietraszek
authors.forename: Y
authors.initials: Y
authors.lastname: Takada
authors.forename: A
authors.initials: A
authors.lastname: Takada
authors.forename: K
authors.initials: K
authors.lastname: Kawabe
mesh_terms: D000818:Animals; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000494:pharmacology* / Q000633:toxicity; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects; D012701:Serotonin / Q000097:blood* / Q000502:physiology; D014661:Vasoconstriction
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D016572:Cyclosporine; D003404:Creatinine