HMGCoA reductase inhibitors and omega-3 fatty acids as adjunctive agents in maintenance immunosuppression after solid organ transplantation.
Omega-3 fatty acids have been shown to play a role in preventing development of both acute and chronic rejection. New evidence also suggests that HMGCoA reductase inhibitors may have an immunomodulatory effect and may decrease the incidence of rejection in both animal and human transplant models. Omega-3 fatty acids and HMGCoA reductase inhibitors may be important adjunctive agents in improving short-and long-term allograft function.
Katznelson
S
S
Division of Nephrology, UCLA Medical Center, USA.
Wilkinson
A H
AH
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D015525:Fatty Acids, Omega-3 / Q000627:therapeutic use*; D006084:Graft Rejection / Q000517:prevention & control; D006801:Humans; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D016377:Organ Transplantation; D014181:Transplantation Immunology
D000276:Adjuvants, Immunologic; D015525:Fatty Acids, Omega-3; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors