title: Langerhans cells in the immunopathology of contact allergic dermatitis.
abstract: The functional morphology, topography and frequency of Langerhans cells (LCs), which are significant factors in the pathogenesis of contact allergic dermatitis (CAD), were studied by histoenzymatic methods (adenosine triphosphatase (ATP-ase), acid phosphatase (AF) and alpha naphtylacetate esterase (ANAE), immunohistochemical methods (indirect immunoperoxidase (IPO) with the monoclonal antibody OKT 6), and the peroxidase-antiperoxidase (PAP) method with the polyclonal S-100 antibody in skin biopsies of 24 patients with CAD, as well in skin biopsies in experimental models in guinea pigs. The results confirmed the significant role of LCs in the pathogenesis of contact allergic dermatitis.
authors.affiliation: Klinika za kozne i spolne bolesti Medicinskog fakulteta Sveucilista, Zagrebu.
authors.forename: J
authors.initials: J
authors.lastname: Lipozencic
authors.forename: G
authors.initials: G
authors.lastname: Lacković
authors.forename: B
authors.initials: B
authors.lastname: Rode
authors.forename: V
authors.initials: V
authors.lastname: Cajkovac
mesh_terms: D000135:Acid Phosphatase / Q000378:metabolism; D000818:Animals; D000252:Calcium-Transporting ATPases / Q000378:metabolism; D003877:Dermatitis, Contact / Q000201:enzymology / Q000473:pathology*; D004137:Dinitrochlorobenzene / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000201:enzymology / Q000473:pathology*; D009418:S100 Proteins / Q000378:metabolism; D012867:Skin / Q000201:enzymology / Q000473:pathology; D013601:T-Lymphocytes / Q000201:enzymology
chemical_list: D004137:Dinitrochlorobenzene; D009418:S100 Proteins; D000135:Acid Phosphatase; D000252:Calcium-Transporting ATPases