[Yield of ultrasonography-guided transrectal biopsy in the diagnosis of carcinoma of the prostate].
OBJECTIVE
The present study analyzes the combination of digital rectal examination (DRE), prostate specific antigen (PSA), transrectal ultrasound (TRUS) and ultrasound-guided transrectal biopsy in the diagnosis of prostate cancer.


METHODS
115 of 224 patients (51.3%) were biopsied due to a suspicious DRE and/or PSA > 4 ng/ml, and/or DPSA > 0.15, and/or the presence of a hypoechoic lesion on TRUS.


RESULTS
Adenocarcinoma of the prostate was diagnosed in 28 (24.3%) of these 115 patients. The positive predictive value (PPV) for carcinoma of the prostate was 4.76% if PSA was < 4 ng/ml, 5.12% if PSA was 4.1 to 10 ng/ml, and 48% if PSA was > 10 ng/ml. If DPSA is considered, the PPV is 7.4% if PSA is 4.1 to 10 ng/ml and 51.02% if PSA is > 10 ng/ml. If DRE is suspicious, the PPV is 43.6%, with a sensitivity of 85.7% and a specificity of 63.9%. The PPV for carcinoma of the prostate was 34% for a hypoechoic lesion on TRUS, 50% if DRE is suspicious, 53.5% is PSA is > 10 ng/ml and 65% if DRE is suspicious and PSA > 10 ng/ml.


CONCLUSIONS
The detection rate of carcinoma of the prostate is increased when DRE, PSA, TRUS and US-guided transrectal biopsy are used in combination.
Fernández González
I
I
Servicio de Anatomía Patológica, Hospital Universitario de Getafe, Madrid, España.
Ruiz Rubio
J L
JL
Llorente Abarca
C
C
Aramburu González
J A
JA
Montes Díaz
M J
MJ
Herrero Payo
A
A
Sánchez Sánchez
E
E
Berenguer Sánchez
A
A
D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D001706:Biopsy / Q000379:methods; D006801:Humans; D008297:Male; D010173:Palpation; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity; D014463:Ultrasonography
D017430:Prostate-Specific Antigen