title: Demodicidosis or rosacea: what did we treat?
abstract: We report a 75-year-old man with a fulminant rosacea-like eruption, suggestive of demodicidosis. Multiple Demodex folliculorum mites were found in facial scales and pustules and, on histological examination, in the infundibulum of pilosebaceous follicles and in the dermis. Intradermal mites were surrounded either by polymorphonuclear granulocytes and histiocytes, or by a granulomatous infiltrate containing foreign-body giant cells, which had phagocytosed the parasites. Complete recovery, with disappearance of facial mites, was achieved by treatment with a combination of oral and topical metronidazole, although this drug is not known to be miticidal.
authors.affiliation: Department of Dermatology, Academisch Medisch Centrum, University of Amsterdam, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Hoekzema
authors.forename: H J
authors.initials: HJ
authors.lastname: Hulsebosch
authors.forename: J D
authors.initials: JD
authors.lastname: Bos
mesh_terms: D000368:Aged; D000818:Animals; D003937:Diagnosis, Differential; D005148:Facial Dermatoses / Q000175:diagnosis* / Q000188:drug therapy; D006801:Humans; D008297:Male; D008795:Metronidazole / Q000627:therapeutic use; D008924:Mite Infestations / Q000175:diagnosis* / Q000188:drug therapy; D012393:Rosacea / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D008795:Metronidazole