Salivary secretion and histopathological effects after single administration of the muscarinic agonist SNI-2011 in MRL/lpr mice.
The salivary secretion and the histopathological effects after administration of a single dose of cis-2-methylspiro (1,3-oxathiolane-5,3') quinuclidine hydrochloride hemihydrate (SNI-2011) were monitored in adult, male and female MRL/lpr mice, C57BL/6J mice and ICR mice. SNI-2011 (1-10 mg/kg, i.p.), dose-dependently increased the secretion of saliva in MRL/lpr mice. The flow rate decreased gradually over the course of 60 min. The total volume of saliva, secreted in response to SNI-2011, was significantly higher in male than in female MRL/lpr mice, but there was no significant difference in this parameter between male and female C57BL/6J and ICR mice. Degeneration, apparent as atrophy and necrosis of serous cells in MRL/lpr mice, was reversed by treatment with SNI-2011 (3 and 6 mg/kg). These results suggest that SNI-2011 could be useful in the treatment of xerostomia in patients with Sjögren's syndrome.
Iwabuchi
Y
Y
Department of Dental Pharmacology, School of Dentistry at Niigata, Nippon Dental University, Japan.
Katagiri
M
M
Masuhara
T
T
D000818:Animals; D001327:Autoimmune Diseases / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008813:Mice, Inbred ICR; D010277:Parasympathomimetics / Q000008:administration & dosage / Q000633:toxicity*; D010306:Parotid Gland / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D011812:Quinuclidines / Q000008:administration & dosage / Q000633:toxicity*; D012463:Saliva / Q000378:metabolism*; D012469:Salivary Glands / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D012737:Sex Factors; D013045:Species Specificity; D013194:Staining and Labeling; D013361:Sublingual Gland / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013363:Submandibular Gland / Q000187:drug effects / Q000378:metabolism / Q000473:pathology; D013876:Thiophenes
D010277:Parasympathomimetics; D011812:Quinuclidines; D013876:Thiophenes; C059240:cevimeline