title: Repeated hepatic dearterialization for unresectable liver metastases from gastric cancer: review of five cases.
abstract: A novel method of repeated hepatic dearterialization was evaluated in five patients with multiple metastases from gastric cancer in both hepatic lobes. After gastrectomy with extensive lymph node dissection (R2/3), all patients underwent implantation of a vascular occluder around the hepatic artery. Cannulation of the hepatic artery was added for later chemotherapy. The hepatic artery was occluded repeatedly for 1 hour twice daily in combination with intrahepatic infusion of anticancer drugs for as long as possible. Three of five patients demonstrated marked tumour regression with unexpectedly long survival (16 months in two patients and one still alive at 15 months). Carcinoembryonic antigen (CEA) levels decreased to almost normal in four patients who had initially high levels. The present experiences seems to indicate that long survival can be hoped for in patients with advanced gastric cancer with unresectable liver metastases.
authors.affiliation: Second Department of Surgery, Shimane Medical University, Izumo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kimoto
authors.forename: N
authors.initials: N
authors.lastname: Nagasue
authors.forename: H
authors.initials: H
authors.lastname: Kohno
authors.forename: Y C
authors.initials: YC
authors.lastname: Chang
authors.forename: H
authors.initials: H
authors.lastname: Taniura
authors.forename: A
authors.initials: A
authors.lastname: Yamanoi
authors.forename: M
authors.initials: M
authors.lastname: Uchida
authors.forename: Y
authors.initials: Y
authors.lastname: Takemoto
authors.forename: Y
authors.initials: Y
authors.lastname: Makino
authors.forename: T
authors.initials: T
authors.lastname: Nakamura
mesh_terms: D000368:Aged; D003131:Combined Modality Therapy; D005260:Female; D005743:Gastrectomy; D006499:Hepatic Artery / Q000601:surgery*; D006801:Humans; D008026:Ligation; D008102:Liver Circulation; D008113:Liver Neoplasms / Q000556:secondary* / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D012086:Reoperation; D013274:Stomach Neoplasms / Q000473:pathology*