Differential expression of apolipoprotein-D and prostate specific antigen in benign and malignant prostate tissues.
OBJECTIVE
To investigate Apolipoprotein-D (Apo-D) and prostate specific antigen (PSA) immunohistochemical staining of nonmalignant and malignant human prostate tissues.


METHODS
Apolipoprotein-D and PSA immunoreactivity were evaluated by video image analysis in nonmalignant prostates and in 30 stage D2 prostate cancers.


RESULTS
Apolipoprotein-D was detected in all 30 tumors, and the level of staining was elevated in comparison to age-matched nonmalignant prostates (p < 0.05). In contrast, the level of PSA staining in tumors was less than that detected in nonmalignant prostates.


CONCLUSIONS
Apolipoprotein-D is expressed in normal human prostate. Elevated Apo-D staining is associated with advanced prostate cancer.
Aspinall
J O
JO
Department of Surgery, School of Medicine, Flinders University of South Australia, Bedford Park.
Bentel
J M
JM
Horsfall
D J
DJ
Haagensen
D E
DE
Marshall
V R
VR
Tilley
W D
WD
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D001053:Apolipoproteins / Q000096:biosynthesis*; D053399:Apolipoproteins D; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D017430:Prostate-Specific Antigen / Q000096:biosynthesis*; D011469:Prostatic Diseases / Q000378:metabolism*; D011471:Prostatic Neoplasms / Q000378:metabolism*
D001053:Apolipoproteins; D053399:Apolipoproteins D; D017430:Prostate-Specific Antigen