title: Protective effects of prostaglandin E2 on the paraquat-induced constriction of the fetal ductus arteriosus in the rat.
abstract: Pregnant rats on day 21 of gestation received a subcutaneous injection of paraquat (25 mg/kg). Two hr later, some fetuses of these rats received a subcutaneous injection of prostaglandin E2 (PGE2). The caliber of the ductus arteriosus (DA) of fetuses was measured 1 hr later. The DA of fetuses of paraquat-treated pregnant rats was significantly constricted compared with that of fetuses of control pregnant rats given physiological saline. However, the DA of PGE2-treated fetuses of paraquat-treated pregnant rats had a caliber comparable to that of control rats. The maternal plasma PGE2 level decreased following paraquat treatment. These results suggest that the decrease of maternal PGE2 level results in a constriction of the DA of fetuses.
authors.affiliation: Department of Pharmacology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Shirai
authors.forename: M
authors.initials: M
authors.lastname: Motoya
authors.forename: H
authors.initials: H
authors.lastname: Funahashi
authors.forename: T
authors.initials: T
authors.lastname: Masaoka
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Arishima
authors.forename: F
authors.initials: F
authors.lastname: Akahori
authors.forename: Y
authors.initials: Y
authors.lastname: Eguchi
mesh_terms: D000818:Animals; D015232:Dinoprostone / Q000494:pharmacology*; D004373:Ductus Arteriosus / Q000502:physiology* / Q000528:radiation effects; D005260:Female; D005333:Fetus; D008297:Male; D008431:Maternal-Fetal Exchange; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D010269:Paraquat / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D014665:Vasodilator Agents / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: D014665:Vasodilator Agents; D015232:Dinoprostone; D010269:Paraquat