Leukocyte interactions with vascular endothelium. New insights into selectin-mediated attachment and rolling.
Among the earliest signs of inflammation is the capture of leukocytes from the blood stream and their subsequent rolling along the endothelium of postcapillary venules. This commentary summarizes recent insight into the molecular basis of leukocyte rolling gained from gene-targeted mice, Ab blocking studies, and in vitro and in vivo reconstitution assays. These data reveal how the selectins individually and collectively contribute to the process of leukocyte capture and subsequent rolling on vascular endothelium.
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Department of Biomedical Engineering, University of Virginia School of Medicine, Charlottesville 22908, USA.
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D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D015815:Cell Adhesion Molecules / Q000494:pharmacology*; D002465:Cell Movement / Q000187:drug effects*; D019040:E-Selectin; D004730:Endothelium, Vascular / Q000187:drug effects*; D016023:Integrins / Q000502:physiology*; D019041:L-Selectin; D007962:Leukocytes / Q000187:drug effects*; D008562:Membrane Glycoproteins / Q000494:pharmacology; D051379:Mice; D008817:Mice, Mutant Strains; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins / Q000494:pharmacology
D015815:Cell Adhesion Molecules; D019040:E-Selectin; D016023:Integrins; D008562:Membrane Glycoproteins; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D019041:L-Selectin