The tartrolons, new boron-containing antibiotics from a myxobacterium, Sorangium cellulosum.
New antibiotics were isolated from the culture broth of the myxobacterium, Sorangium cellulosum, strain So ce 678. The antibiotics were active against Gram-positive bacteria and mammalian cells. They were named tartrolon A and B. Tartrolon B contains a boron atom. The boron binding region of tartrolon is identical with that of boromycin and aplasmomycin.
Irschik
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H
GBF, Gesellschaft für Biotechnologische Forschung, Dept. of Biology of Natural Products, Braunschweig, Germany.
Schummer
D
D
Gerth
K
K
Höfle
G
G
Reichenbach
H
H
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology*; D001881:Borates / Q000378:metabolism / Q000494:pharmacology; D001896:Boron Compounds / Q000378:metabolism* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004269:DNA, Bacterial / Q000096:biosynthesis / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000378:metabolism; D007783:Lactones / Q000378:metabolism / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009231:Myxococcales / Q000737:chemistry / Q000378:metabolism*; D012329:RNA, Bacterial / Q000096:biosynthesis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism
D000900:Anti-Bacterial Agents; D001881:Borates; D001896:Boron Compounds; D004269:DNA, Bacterial; D007783:Lactones; D012329:RNA, Bacterial; C092169:tartrolon A; C092170:tartrolon B