Recurrent anaplastic ependymoma with an abnormal karyotype and c-myc proto-oncogene overexpression.
Cytogenetic analysis on a supratentorial, recurrent, anaplastic ependymoma from a 29-year-old female disclosed the presence of an abnormal clone with the karyotype 46,XX,der(8)t(8;11)(q24;p11),-11,add(?)t(?;11)(?;q13). By the Northern hybridization assay and immunohistochemical staining, tumor cells revealed overexpression of c-myc proto-oncogene, although no evidence of amplification or structural rearrangement of this gene was found.
Debiec-Rychter
M
M
Department of Oncology, Medical Academy of Lodz, Poland.
Lasota
J
J
Alwasiak
J
J
Liberski
P P
PP
D000328:Adult; D015152:Blotting, Northern; D001932:Brain Neoplasms / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D004806:Ependymoma / Q000235:genetics* / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D007621:Karyotyping; D008854:Microscopy, Electron; D009364:Neoplasm Recurrence, Local; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc / Q000378:metabolism*; D013194:Staining and Labeling
C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D016271:Proto-Oncogene Proteins c-myc