The chemical nature, purity and stability of 99mTc-N-(2,6-Diethyl-3-iodo-phenylcarbamoylmethyl)-iminodiacetic acid.
The chemical purity and stability of a radio pharmaceutical 99mTc-N-(2,6-diethyl-3-iodo-phenylcarbamoylmethyl)-iminodiacetic acid (IODIDA) has been studied using HPLC. The HPLC results indicate that IODIDA decomposed into at least three species after 99mTc labelling, and the amount of these varied with time. Mass spectra obtained by negative ion FABMS of no-carrier-added (NCA) Tc-labelled IODIDA showed, in addition to the molecular ion and the sodium adduct of N-(2,6-diethyl-3-iodo-phenylcarbamoylmethyl)-iminodiacetic acid, peaks corresponding to sodium containing dimers, trimers and tetramers. Several peaks were also found that may be assigned to 99Tc(I) containing dimers, trimers and tetramers.
Lundberg
P S
PS
Department of Radiation Physics, University of Göteborg, Sahlgrenska Hospital, Sweden.
Jacobsson
L
L
Stenhagen
G
G
Mårtensson
J
J
Fjälling
M
M
D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D007098:Imino Acids / Q000737:chemistry* / Q000302:isolation & purification; D015394:Molecular Structure; D015609:Organotechnetium Compounds / Q000737:chemistry* / Q000302:isolation & purification; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013997:Time Factors
D007098:Imino Acids; D015609:Organotechnetium Compounds; C051086:technetium Tc 99m 2,6-diethyl-3-iodo-HIDA