Pingyangmycin as a 99mTc carrier in tumor localization.
A simple method of preparation of 99mTc-pingyangmycin (PYM) for clinical use has been established using super-micro-amounts of SnCl2 as a reductant under dark conditions. The labeling efficiency was higher than 96%, and further purification was not necessary. The effect of ascorbic acid on the distribution of 99mTc-PYM had been investigated. Ascorbic acid increased uptake of 99mTc-PYM in the tumor. Tumor uptake increased with increasing concentration of ascorbic acid. Tumor-blood, tumor-liver, tumor-lung ratios at 1.5 h after 99mTc-PYM administration were 5.19 +/- 1.64, 2.71 +/- 0.51 and 4.15 +/- 0.57, respectively. Preliminary clinical trials in nine patients showed that 99mTc-PYM is a potentially useful tracer for tumor detection with good sensitivity and specificity (true positive 7/7, true negative 1/1, and false positive 1/1).
Huang
T
T
Department of Nuclear Medicine, Beijing Institute for Cancer Research, China.
Zhang
Y
Y
Wang
J
J
Huang
J
J
Liu
D
D
Mong
S
S
D000368:Aged; D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000493:pharmacokinetics; D001761:Bleomycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000493:pharmacokinetics; D002286:Carcinoma, Ehrlich Tumor / Q000000981:diagnostic imaging* / Q000378:metabolism; D002294:Carcinoma, Squamous Cell / Q000000981:diagnostic imaging* / Q000473:pathology; D004355:Drug Stability; D005260:Female; D006801:Humans; D007553:Isotope Labeling / Q000379:methods; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D008875:Middle Aged; D015609:Organotechnetium Compounds / Q000737:chemistry / Q000493:pharmacokinetics; D011859:Radiography; D011877:Radionuclide Imaging; D013667:Technetium / Q000493:pharmacokinetics; D014018:Tissue Distribution
D000903:Antibiotics, Antineoplastic; D015609:Organotechnetium Compounds; C095747:technetium Tc 99m pingyangmycin; D001761:Bleomycin; D013667:Technetium; C021771:zhengguangmycin