title: [The effectiveness of so-called potentiated penicillins (augmentin and tazobactam) in vitro].
abstract: The resistance of bacterial strains to beta-lactam antibiotics (penicillins and cephalosporins) is due to transfer of genes coding the production of enzymes-beta-lactamases. These enzymes--penicillinases and cephalosporinases--can hydrolyse beta-lactam antibiotics. The using of beta-lactamase inhibitors in combination with some beta-lactam antibiotics is a suitable alternative in the present unfavourable situation in chemotherapy (increase of occurrence of gram-negative and gram-positive penicillin-cephalosporin-resistant bacterial strains). In this communication the authors present the review of efficiency of three, in clinical practice mostly used potentiated penicillins: Augmentin (amoxicillin + clavulanate), Unasyn (ampicillin + sulbactam) and Tazobac (piperacillin + tazobactam). Tazobactam seems to be the most promising beta-lactamase inhibitor which has, unlike clavulanate and sulbactam, its own antibiotic activity.
authors.affiliation: Ustav preventívnej a klinickej medicíny, Bratislava.
authors.forename: J
authors.initials: J
authors.lastname: Blahová
authors.forename: M
authors.initials: M
authors.lastname: Hupková
authors.forename: V
authors.initials: V
authors.lastname: Krcméry
mesh_terms: D000658:Amoxicillin / Q000494:pharmacology; D019980:Amoxicillin-Potassium Clavulanate Combination; D000667:Ampicillin / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects*; D002969:Clavulanic Acids / Q000494:pharmacology; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D010397:Penicillanic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D013407:Sulbactam / Q000494:pharmacology; D000078142:Tazobactam; D065093:beta-Lactamase Inhibitors
chemical_list: D002969:Clavulanic Acids; D065093:beta-Lactamase Inhibitors; C035444:sultamicillin; D019980:Amoxicillin-Potassium Clavulanate Combination; D000667:Ampicillin; D000658:Amoxicillin; D010397:Penicillanic Acid; D013407:Sulbactam; D000078142:Tazobactam