title: Apparent lack of response of salmon affected by pancreas disease to pancreatic enzyme replacement therapy.
abstract: A trial was conducted to establish whether there would be any benefit in feeding mammalian pancreatic enzymes to farmed salmon clinically affected by pancreas disease. Pancreatic enzymes were incorporated at a rate of 4 kg/tonne of feed and fed at 0.6 to 0.9 per cent bodyweight/day for 41 days to one cage of salmon. The weights, lengths and condition factors were established for the fish before and after the feeding trial and compared with those for an adjacent cage of untreated fish. Histopathology and blood amylase and lipase activities were monitored weekly. No significant increases in weight or condition factor, and no reduction in mortalities were recorded. Histopathology confirmed the presence of pancreas disease throughout the trial and there were concurrent skeletal and cardiac myopathies. Blood amylase activities showed no significant change and were considered to be within normal ranges; blood lipase activity remained undetectable.
authors.affiliation: Institute of Aquaculture, University of Stirling, Scotland.
authors.forename: H D
authors.initials: HD
authors.lastname: Rodger
authors.forename: K
authors.initials: K
authors.lastname: Murphy
authors.forename: E M
authors.initials: EM
authors.lastname: Drinan
authors.forename: G
authors.initials: G
authors.lastname: Kennedy
mesh_terms: D000681:Amylases / Q000097:blood; D000821:Animal Feed; D000818:Animals; D017756:Aquaculture; D001835:Body Weight / Q000187:drug effects; D009202:Cardiomyopathies / Q000097:blood / Q000401:mortality / Q000628:therapy / Q000662:veterinary; D004196:Disease Outbreaks / Q000662:veterinary; D005393:Fish Diseases / Q000097:blood / Q000401:mortality / Q000628:therapy*; D007494:Ireland / Q000453:epidemiology; D008049:Lipase / Q000097:blood; D009135:Muscular Diseases / Q000097:blood / Q000401:mortality / Q000628:therapy / Q000662:veterinary; D010182:Pancreatic Diseases / Q000097:blood / Q000401:mortality / Q000628:therapy / Q000662:veterinary*; D010184:Pancreatic Extracts / Q000627:therapeutic use*; D012474:Salmon
chemical_list: D010184:Pancreatic Extracts; D008049:Lipase; D000681:Amylases