Effect of neurotensin and substance P on adrenal cortex regeneration.
The influence of neurotensin (NT) and substance P (SP) on the early stage of adrenal regeneration was investigated. Neurotensin (5 and 50 micrograms/kg) and SP (10 and 100 micrograms/kg) were given to rats subjected to adrenal enucleation combined with contralateral adrenalectomy. The mitotic index was employed to assess cell growth, and plasma corticosterone was determined by a radioimmunological assay. The animals were killed 4 and 8 days after operation. Neurotensin did not evoke any significant changes either in the proliferation ratio or corticosterone production of regenerating adrenal cortex. However, it was found that SP (100 micrograms/kg) stimulated both the proliferation and steroidogenesis on the eighth day after operation.
Zieleniewski
W
W
Department of Clinical Endocrinology, University School of Medicine, Lodz, Poland.
Zieleniewski
J
J
D000302:Adrenal Cortex / Q000166:cytology / Q000187:drug effects* / Q000502:physiology*; D000818:Animals; D002455:Cell Division; D003345:Corticosterone / Q000097:blood; D008297:Male; D008940:Mitotic Index / Q000187:drug effects; D009496:Neurotensin / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012038:Regeneration; D013373:Substance P / Q000494:pharmacology*
D013373:Substance P; D009496:Neurotensin; D003345:Corticosterone