Effects of juvenile hormone analogues (JHA) on the development of Trypanosoma cruzi.
Juvenile hormone analogues were tested for their lytic activity on Trypanosoma cruzi Chagas, 1909 blood tripomastigotes cultivated in vitro. The results indicated that the carbamate 4 and the phenoxyphenol derivative 1 are considered good candidates for blood sterilization. The compounds were also assayed for inhibition of development of parasites in infected mice showing a moderated degree of activity.
Fichera
L
L
Instituto Nacional de Chagas, Buenos Aires, Argentina.
Esteva
M
M
Wimmer
Z
Z
Rodriguez
J B
JB
Gros
E G
EG
D000818:Animals; D002219:Carbamates / Q000494:pharmacology; D014355:Chagas Disease / Q000188:drug therapy*; D007605:Juvenile Hormones / Q000494:pharmacology* / Q000627:therapeutic use*; D051379:Mice; D010636:Phenols / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000254:growth & development*
D002219:Carbamates; D007605:Juvenile Hormones; D010636:Phenols; D014344:Trypanocidal Agents