Neutrophil and monocyte beta 2-integrin expression in trisomic fetuses.
Flow cytometry was used to measure neutrophil and monocyte beta 2-integrin expression in fetuses with trisomy 18 (n = 7) and trisomy 21 (n = 7) at 20-25 weeks' gestation. The values were compared with those of 112 chromosomally normal fetuses. There were no significant differences in beta 2-integrin expression between normal and aneuploid fetuses. These findings demonstrate that in trisomies 21 and 18, alteration in beta 2-integrin expression is unlikely to contribute to the pathogenesis of immunological deficiencies that have been observed in these aneuploidies both prenatally and postnatally.
Makrydimas
G
G
Harris Birthright Research Centre for Fetal Medicine, King's College Hospital School of Medicine, London, U.K.
Thilaganathan
B
B
Plachouras
N
N
Nicolaides
K H
KH
D000782:Aneuploidy; D018821:CD18 Antigens; D004314:Down Syndrome / Q000276:immunology; D005260:Female; D005333:Fetus / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D016023:Integrins / Q000096:biosynthesis*; D009000:Monocytes / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D011247:Pregnancy; D014314:Trisomy / Q000276:immunology*
D018821:CD18 Antigens; D016023:Integrins