title: Interference by hydroxyethyl starch used for vascular filling in latex agglutination test for cryptococcal antigen.
abstract: The glucuronoxylomannan component of the Cryptococcus neoformans capsular polysaccharide confers serotype specificity, and its detection in cerebrospinal fluid or serum by the latex agglutination test is used for diagnosis. Low-molecular-weight hydroxyethyl starches can be used as an alternative to albumin for vascular filling. This study reports the occurrence of a false-positive result with the Pastorex Cryptococcus test (Sanofi Diagnostics Pasteur, Marnes la Coquette, France) for a patient receiving hydroxyethyl starch characterized by a substitution ratio of 0.6 (Elohes, Biosedra, Sèvres, France).
authors.affiliation: Laboratoire de Parasitologie-Mycologie, Hopital Jean Minjoz, Besançon, France.
authors.forename: L
authors.initials: L
authors.lastname: Millon
authors.forename: T
authors.initials: T
authors.lastname: Barale
authors.forename: M C
authors.initials: MC
authors.lastname: Julliot
authors.forename: J
authors.initials: J
authors.lastname: Martinez
authors.forename: G
authors.initials: G
authors.lastname: Mantion
mesh_terms: D000946:Antigens, Fungal / Q000032:analysis* / Q000737:chemistry; D002240:Carbohydrate Sequence; D003453:Cryptococcosis / Q000175:diagnosis*; D003455:Cryptococcus neoformans / Q000276:immunology*; D005189:False Positive Reactions; D006801:Humans; D006895:Hydroxyethyl Starch Derivatives / Q000737:chemistry / Q000627:therapeutic use; D007841:Latex Fixation Tests / Q000379:methods*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D011134:Polysaccharides / Q000737:chemistry / Q000276:immunology
chemical_list: D000946:Antigens, Fungal; D006895:Hydroxyethyl Starch Derivatives; D011134:Polysaccharides; C027478:glucuronoxylomannan