Effect of a corn diet during development on [3H]-spiperone binding in the brain of rats at the perinatal stage.
A model of undernutrition based on feeding with a corn-diet (tryptophan deficient) was used to study maturation and physiology of the rat brain 5-HTergic system. Previously, using that model, we observed a decrease in 5-HT uptake in rat brain slices, assuming that some compensatory mechanisms could be implicated at the synaptic level on those conditions. Body, brain weight, and total [3H]-spiperone binding were recorded at two fetal ages and newborn pups from mothers were fed with a corn-diet and with a corn-lysine diet. Significant decreases in body weight and in [3H]-spiperone binding were observed at all ages studied in the corn-based diet groups with respect to controls at the first postnatal day of age, whereas at the 18th gestation day, the [3H]-spiperone binding was higher in the protein restricted and corn-lysine supplemented group than in the control group. Results suggested that expression of 5-HT receptors and possibly their synthesis may be limited at the synaptic level on undernutrition conditions.
Beas-Zárate
C
C
Division de Patología Experimental, Centro de Investigacion Biomédica de Occidente, IMSS, Guadalajara, Jalisco, Mexico.
Ortuño-Sahagún
D
D
Del Angel Meza
A R
AR
Feria-Velasco
A
A
D000375:Aging / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn / Q000254:growth & development / Q000378:metabolism*; D001835:Body Weight; D001921:Brain / Q000033:anatomy & histology / Q000196:embryology / Q000378:metabolism*; D004032:Diet; D005314:Embryonic and Fetal Development; D005260:Female; D005333:Fetus / Q000033:anatomy & histology / Q000378:metabolism* / Q000502:physiology; D009929:Organ Size; D051381:Rats; D017208:Rats, Wistar; D013134:Spiperone / Q000378:metabolism*; D014316:Tritium; D003313:Zea mays
D014316:Tritium; D013134:Spiperone