Effect of cytokine-induced migration of Langerhans cells on corneal allograft survival.
The unique paucity of Ia+ Langerhans cells (LCs) in the central cornea contributes to the immunological privilege of corneal allografts. A variety of stimuli can induce the centripetal migration of peripheral LCs. At least one of these stimuli (i.e. latex bead instillation) induces interleukin-1 (IL-1) secretion by corneal cells which acts as a potent chemoattractant for LCs. Within 30 minutes of intracorneal injection of IL-1, centripetal migration of LCs can be detected. The presence of donor-derived LCs in corneal allografts doubles the incidence of rejection of fully allogeneic corneal allografts as well as MHC matched, multiple minor H mismatched corneal allografts. Although the presence of donor-specific LCs greatly jeopardises corneal allograft survival, migration of host-derived LCs into corneal allografts does not appear to increase the risk of rejection.
Niederkorn
J Y
JY
Department of Ophthalmology, University of Texas Southwestern Medical Center, Dallas 75235-9057, USA.
D000818:Animals; D017951:Antigen Presentation; D002465:Cell Movement / Q000187:drug effects; D003315:Cornea / Q000166:cytology; D016039:Corneal Transplantation / Q000276:immunology*; D016207:Cytokines / Q000502:physiology*; D006084:Graft Rejection / Q000276:immunology; D006085:Graft Survival / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D007801:Langerhans Cells / Q000276:immunology*; D008912:Minor Histocompatibility Loci; D051381:Rats
D016207:Cytokines; D000949:Histocompatibility Antigens Class II; D007375:Interleukin-1