title: Strategies for studying mouse and human immune responses to human papillomavirus type 16.
abstract: Cytotoxic T lymphocytes (CTL) are an important protective mechanism in viral infection and can be effective against tumours. We have investigated the tumour-associated E6 and E7 genes of human papillomavirus type 16 as CTL targets. In H-2b mice we have defined epitopes in E6 and E7 which can readily generate CTL in vivo and we have shown that HLA-A2.1 transgenic mice can generate an HLA-A2.1-restricted response. We have been unable to reveal a primed CTL response in humans. These paradoxical findings imply that human papillomavirus may fail to stimulate a systemic CTL response and/or employ strategies for evading or down-regulating such a response.
authors.affiliation: ICRF Tumour Immunology Unit, University College London Medical School, UK.
authors.forename: P C
authors.initials: PC
authors.lastname: Beverley
authors.forename: E
authors.initials: E
authors.lastname: Sadovnikova
authors.forename: X
authors.initials: X
authors.lastname: Zhu
authors.forename: J
authors.initials: J
authors.lastname: Hickling
authors.forename: L
authors.initials: L
authors.lastname: Gao
authors.forename: B
authors.initials: B
authors.lastname: Chain
authors.forename: S
authors.initials: S
authors.lastname: Collins
authors.forename: L
authors.initials: L
authors.lastname: Crawford
authors.forename: K
authors.initials: K
authors.lastname: Vousden
authors.forename: H J
authors.initials: HJ
authors.lastname: Stauss
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000939:Epitopes / Q000276:immunology; D005814:Genes, Viral; D015789:HLA-A2 Antigen / Q000276:immunology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008969:Molecular Sequence Data; D027383:Papillomaviridae / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000276:immunology*; D014616:Vaccinia virus; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D000939:Epitopes; D015789:HLA-A2 Antigen; D014614:Vaccines, Synthetic; D014765:Viral Vaccines