Schizophrenia with karyotype mosaic 47,XXY/48,XXY + 8.
A case of severe schizophrenia is described in a patient with chromosomal mosaicism of Klinefelter's syndrome (XXY) and trisomy 8. The literature of both syndromes is reviewed and the aetiological implications discussed.
Ong
S H
SH
Behaviour Modification and Rehabilitation Unit, Horton Hospital, Epsom, Surrey, UK.
Robertson
J R
JR
D000015:Abnormalities, Multiple / Q000235:genetics; D001521:Behavior Therapy; D002869:Chromosome Aberrations / Q000523:psychology*; D025063:Chromosome Disorders; D002898:Chromosomes, Human, Pair 8; D003024:Clozapine / Q000627:therapeutic use; D003131:Combined Modality Therapy; D006801:Humans; D007713:Klinefelter Syndrome / Q000150:complications* / Q000523:psychology; D008297:Male; D008875:Middle Aged; D009030:Mosaicism; D012563:Schizophrenia, Paranoid / Q000150:complications / Q000188:drug therapy / Q000235:genetics* / Q000628:therapy; D014314:Trisomy
D003024:Clozapine