title: A comparative review of the adverse effect profiles of heparins and heparinoids.
abstract: On the basis of the results of the 11 studies reviewed, thromboprophylaxis with unfractionated heparin, low molecular weight (LMW) heparin or a heparinoid (danaparoid sodium; Org 10172) in patients undergoing total hip replacement did not show any important clinical differences with respect to the tolerability profiles of the different compounds. However, as a result of the great variability in the presentation and evaluation of blood losses and bleeding complications in these studies, it is mandatory to perform a direct comparison of the different compounds in question in a double-blind, prospective clinical study.
authors.affiliation: Department of Orthopaedics, Aalborg Hospital, Denmark.
authors.forename: L C
authors.initials: LC
authors.lastname: Borris
authors.forename: M R
authors.initials: MR
authors.lastname: Lassen
mesh_terms: D002809:Chondroitin Sulfates / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003871:Dermatan Sulfate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006470:Hemorrhage / Q000139:chemically induced; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006496:Heparinoids / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006497:Heparan Sulfate / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D006622:Hip Prosthesis; D006801:Humans; D008970:Molecular Weight; D011183:Postoperative Complications / Q000139:chemically induced; D013921:Thrombocytopenia / Q000139:chemically induced; D013927:Thrombosis / Q000517:prevention & control; D014946:Wound Infection / Q000139:chemically induced
chemical_list: D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D005343:Fibrinolytic Agents; D006493:Heparin; D006496:Heparinoids; D006497:Heparan Sulfate; C035838:danaparoid