[Inhibition of voltage-gated K+, Na+ and Ca2+ currents in neuroblastoma x glioma hybrid cells by paeonol].
The effects of Paeonol (25 micrograms/ml to 400 micrograms/ml) on the membrane currents of NG108-15 cells were observed by means of whole cell voltage-clamp technique. The results showed that PA inhibited delayed outward K+ current (IK), and to a less extend, that the Na+ current (INa). Two Ca2+ currents (T and L type) were also inhibited significantly. All of the effects mentioned above were dose-dependent and reversible.
Hu
Q
Q
Shanghai Institute of Physiology, Chinese Academy of Sciences, Shanghai.
Shi
Y L
YL
D000098:Acetophenones / Q000494:pharmacology*; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects; D005910:Glioma / Q000473:pathology; D006822:Hybrid Cells; D015640:Ion Channel Gating / Q000187:drug effects*; D007473:Ion Channels / Q000187:drug effects*; D051379:Mice; D009447:Neuroblastoma / Q000473:pathology; D015221:Potassium Channels / Q000187:drug effects; D051381:Rats; D015222:Sodium Channels / Q000187:drug effects; D014407:Tumor Cells, Cultured
D000098:Acetophenones; D015220:Calcium Channels; D007473:Ion Channels; D015221:Potassium Channels; D015222:Sodium Channels; C013638:paeonol