Trisomy 14: a recurring cytogenetic abnormality associated with myeloid disorders.
Trisomy 14 as single karyotype aberration was detected in three patients, two with acute myeloblastic leukemia, AML-M2 type, and one with aplastic anemia. These new observations and the 28 previously reported cases confirm that trisomy 14 is a primary non random change, mostly confined to myeloid disorders.
Poirel
H
H
Unité INSERM U301, Institut de Génétique Moléculaire, Paris, France.
Jonveaux
P
P
Daniel
M T
MT
Berger
R
R
D000328:Adult; D000368:Aged; D000741:Anemia, Aplastic / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D001855:Bone Marrow Diseases / Q000235:genetics; D002883:Chromosomes, Human, Pair 14; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000235:genetics* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics; D014314:Trisomy