title: Caudal raphe-dorsal vagal complex peptidergic projections: role in gastric vagal control.
abstract: Subpopulations of raphe pallidus (Rpa) and raphe obscurus (Rob) neurons containing TRH, serotonin (5-HT), and substance P contribute projections to the dorsal vagal complex (DVC). Activation of Rpa and Rob neurons induces a vagal cholinergic-dependent stimulation of gastric secretory and motor function and modulates resistance of the gastric mucosa to gastric injury in rats and cats. The caudal raphe nuclei-DVC pathways containing TRH/5-HT are involved in mediating cold-induced vagal stimulation of gastric function and erosion formation. These results suggest that Rpa/Rob-DVC projections containing TRH/5-HT may be an important pathways in the medullary regulation of vagal activity to the viscera.
authors.affiliation: CURE/Gastroenteric Biology Center, Department of Medicine, UCLA 90073, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Taché
authors.forename: H
authors.initials: H
authors.lastname: Yang
authors.forename: H
authors.initials: H
authors.lastname: Kaneko
mesh_terms: D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D006801:Humans; D009474:Neurons / Q000502:physiology; D009479:Neuropeptides / Q000502:physiology*; D011903:Raphe Nuclei / Q000502:physiology*; D012701:Serotonin / Q000502:physiology; D017552:Solitary Nucleus / Q000502:physiology*; D013270:Stomach / Q000294:innervation*; D013373:Substance P / Q000502:physiology; D013973:Thyrotropin-Releasing Hormone / Q000502:physiology; D014630:Vagus Nerve / Q000502:physiology*
chemical_list: D009479:Neuropeptides; D012701:Serotonin; D013373:Substance P; D013973:Thyrotropin-Releasing Hormone