Growth-phase regulation of plasmid virulence genes in Salmonella.
Virulence genes in the genus Salmonella are regulated by growth phase and by environmental signals, which allows a sequential program of expression during infection. Conditions that promote the expression of loci required in systemic infection, including the plasmid-encoded spv genes, are the opposite of the factors that induce genes involved in the invasion of epithelial cells in the gastrointestinal tract.
Guiney
D G
DG
Dept of Medicine 0640, UCSD School of Medicine, La Jolla, CA 92093-0640, USA.
Libby
S
S
Fang
F C
FC
Krause
M
M
Fierer
J
J
D000818:Animals; D015964:Gene Expression Regulation, Bacterial; D006801:Humans; D010957:Plasmids; D012475:Salmonella / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics