Galanin and somatostatin inhibition of neurokinin A and B induced airway mucus secretion in the rat.
Neurokinin A and B are present in neurons situated in lung and NK-1 receptors have been described on tracheal submucosal gland cells. In the present study we compared the ability of substance P (SP), neurokinin A (NKA) and neurokinin B (NKB) to stimulate airway mucus secretion. Furthermore, we characterized the interaction of NKA and NKB with galanin and somatostatin. The rank order of the tachykinins to stimulate airway mucus secretion was SP > NKA > NKB suggesting that NK-1 receptors mediate these effects(EC50:SP: 50 nmol/l, NKA: 200 nmol/l, NKB: 400 nmol/l). Galanin and somatostatin were equally potent to inhibit NK-A and NK-B stimulated airway mucus release. These results suggest that NK-A and NK-B are potent stimulators of airway macromolecule secretion. Galanin and somatostatin potently inhibit these actions of the tachykinins. Therefore, airway mucus secretion is controlled by a complex network of several different mediators.
Wagner
U
U
Department of Internal Medicine, Philipps-University of Marburg, Germany.
Fehmann
H C
HC
Bredenbröker
D
D
Yu
F
F
Barth
P J
PJ
von Wichert
P
P
D000818:Animals; D019004:Galanin; D008297:Male; D009093:Mucus / Q000378:metabolism; D015288:Neurokinin A / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D015287:Neurokinin B / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D009479:Neuropeptides / Q000494:pharmacology; D010455:Peptides / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000494:pharmacology*; D014132:Trachea / Q000187:drug effects / Q000378:metabolism*
D009479:Neuropeptides; D010455:Peptides; D013004:Somatostatin; D015288:Neurokinin A; D015287:Neurokinin B; D019004:Galanin