Role of protease inhibition in myocardial preservation following ischemia and reperfusion.
Aprotinin, a naturally occurring protease inhibitor, in concentrations of 10(6) KIU/L was found to have no effect on myocardial performance in normally perfused isolated rat hearts, before ischemia. Given during the preischemic period, the drug had a significant protective effect on the reperfused hearts, following cardioplegic ischemia: better contractility upon reperfusion (p < 0.011), faster decline of the ischemic contracture, higher coronary flow (p < 0.025), lower AV-difference (p < 0.05), and lower CPK levels (p < 0.01).
Gurevitch
J
J
Department of Thoracic and Cardiovascular Surgery, Elias Souraski, Tel-Aviv Medical Center, Tel-Aviv University, Israel.
Paz
Y
Y
Barak
J
J
Matsa
M
M
Kramer
A
A
Pevni
D
D
Hochhauser
E
E
Yakirevich
V
V
D000818:Animals; D007611:Aprotinin / Q000008:administration & dosage / Q000494:pharmacology*; D003326:Coronary Circulation / Q000187:drug effects; D003402:Creatine Kinase / Q000097:blood; D006321:Heart / Q000187:drug effects*; D006324:Heart Arrest, Induced; D006439:Hemodynamics / Q000187:drug effects; D066298:In Vitro Techniques; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects; D017202:Myocardial Ischemia; D015425:Myocardial Reperfusion; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D007611:Aprotinin; D003402:Creatine Kinase