title: CGRP in peripherally axotomized mesencephalic trigeminal neurones of the rat.
abstract: Immunoreactivities for substance P (SP-ir) and calcitonin gene-related peptide (CGRP-ir) were examined in neurones in the mesencephalic trigeminal tract nucleus of nerve-injured rats. One week following unilateral transection of the trigeminal root, the masseteric nerve (MN) or the inferior alveolar nerve (IAN), CGRP-ir but not SP-ir was detected in these neurones bilaterally with ipsilateral dominance. Most of the CGRP-ir (immunoreactive) neurones were retrogradely labelled when fluorogold (FG) had been applied to the proximal stump of the MN or the IAN. Sham surgery including insult to the masseter muscle induced CGRP-ir while skin incision did not.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Okayama University Dental School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Yoshida
authors.forename: H
authors.initials: H
authors.lastname: Ichikawa
authors.forename: T
authors.initials: T
authors.lastname: Sugimoto
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism*; D005456:Fluorescent Dyes; D007150:Immunohistochemistry; D008297:Male; D008636:Mesencephalon / Q000166:cytology / Q000378:metabolism*; D009474:Neurons / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013266:Stilbamidines; D013373:Substance P / Q000096:biosynthesis; D014276:Trigeminal Nerve / Q000166:cytology / Q000378:metabolism*
chemical_list: C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D005456:Fluorescent Dyes; D013266:Stilbamidines; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide