title: New oral dosage form for elderly patients. II. Release behavior of benfotiamine from silk fibroin gel.
abstract: Silk fibroin gel (SFG) containing benfotiamine (BTMP) was prepared. The release behavior of BTMP from SFG was studied as a function of silk fibroin (SF) content and glycerol content, and the influence of the existence of beta-cyclodextrin (beta-CD) on the physicochemical properties of SFG were investigated. The release rate of BTMP from SFG was retarded by an increase in SF concentration. The addition of beta-CD affected both the release properties and rheological properties of the SFG. It was found from the results of the "paddle-bead method" that the release profiles of BTMP from SFG were inversely proportional to the SFG firmness.
authors.affiliation: Pharmaceutical Department, Tokyo Women's Medical College, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hanawa
authors.forename: A
authors.initials: A
authors.lastname: Watanabe
authors.forename: T
authors.initials: T
authors.lastname: Tsuchiya
authors.forename: R
authors.initials: R
authors.lastname: Ikoma
authors.forename: M
authors.initials: M
authors.lastname: Hidaka
authors.forename: M
authors.initials: M
authors.lastname: Sugihara
mesh_terms: D000276:Adjuvants, Immunologic / Q000737:chemistry*; D000284:Administration, Oral; D000375:Aging / Q000502:physiology*; D055598:Chemical Phenomena; D002626:Chemistry, Pharmaceutical; D002627:Chemistry, Physical; D003505:Cyclodextrins / Q000737:chemistry; D004304:Dosage Forms; D005349:Fibroins / Q000737:chemistry*; D005782:Gels / Q000737:chemistry*; D006801:Humans; D008409:Mastication; D012995:Solubility; D013831:Thiamine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000737:chemistry; D047392:beta-Cyclodextrins
chemical_list: D000276:Adjuvants, Immunologic; D003505:Cyclodextrins; D004304:Dosage Forms; D005782:Gels; D047392:beta-Cyclodextrins; D005349:Fibroins; C031215:betadex; D013831:Thiamine; C013835:benphothiamine