title: Electron-microscopic and immunohistochemical studies of Langerhans cells and Thy-1-positive cells in mouse tongue epithelium subjected to local hyperthermia.
abstract: Local hyperthermia via skin has been used to treat cancer but may suppress local immune responses as a side-effect. To examine effects of heat on immunologically responsive cells in oral mucosa, mouse tongues were heated by an implant system at 43 degrees C for 20 min. The densities of Langerhans cells and Thy-1-positive cells rapidly increased within 3 h after the treatment, then returned to a normal level after 7 days. Electron microscopy confirmed that Langerhans cells in the tongue epithelium formed clusters with lymphocytic cells, suggesting an active response to the hyperthermia.
authors.affiliation: Department of Oral Surgery, Nagoya University, School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Mitsudo
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: I
authors.initials: I
authors.lastname: Tohnai
authors.forename: M
authors.initials: M
authors.lastname: Ueda
authors.forename: H
authors.initials: H
authors.lastname: Kotani
authors.forename: T
authors.initials: T
authors.lastname: Hoshino
mesh_terms: D000251:Adenosine Triphosphatases / Q000032:analysis; D000818:Animals; D001485:Basement Membrane / Q000276:immunology / Q000473:pathology; D002452:Cell Count; D004848:Epithelium / Q000276:immunology / Q000473:pathology; D005260:Female; D005455:Fluorescent Antibody Technique; D006979:Hyperthermia, Induced / Q000295:instrumentation; D007150:Immunohistochemistry; D007801:Langerhans Cells / Q000473:pathology*; D008214:Lymphocytes / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D008854:Microscopy, Electron; D009061:Mouth Mucosa / Q000276:immunology / Q000473:pathology; D013194:Staining and Labeling; D018800:Thy-1 Antigens / Q000032:analysis*; D014059:Tongue / Q000276:immunology / Q000473:pathology*
chemical_list: D018800:Thy-1 Antigens; D000251:Adenosine Triphosphatases