[The antigen-specific activity of a multicomponent vaccine administered orally and subcutaneously].
The antigen-specific activity of polycomponent vaccine VP-4 consisting of Klebsiella pneumoniae, Staphylococcus aureus, Proteus vulgaris and Escherichia coli antigens was studied. The same form of the vaccine was used for both subcutaneous injection and oral administration. The oral administration of the preparation to rabbits and guinea pigs induced a rise in the level of antibodies to all components of the vaccine in their blood sera, the optimum oral doses exceed only 2- to 4-fold the doses used for subcutaneous injection. The form of vaccine VP-4, developed for subcutaneous injection, may be recommended for wider trials with its oral administration.
Mansurova
N L
NL
Chuprinina
R P
RP
Egorova
N B
NB
Kuz'mina
L A
LA
Skorikova
I G
IG
Kaverina
K G
KG
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000097:blood; D000942:Antigens, Bacterial / Q000008:administration & dosage* / Q000276:immunology; D001428:Bacterial Vaccines / Q000008:administration & dosage* / Q000276:immunology; D000939:Epitopes / Q000276:immunology*; D004926:Escherichia coli / Q000276:immunology*; D006168:Guinea Pigs; D007114:Immunization / Q000379:methods; D007279:Injections, Subcutaneous; D007711:Klebsiella pneumoniae / Q000276:immunology*; D011514:Proteus vulgaris / Q000276:immunology*; D011817:Rabbits; D013211:Staphylococcus aureus / Q000276:immunology*; D017778:Vaccines, Combined
D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D000939:Epitopes; C088865:VP-4 vaccine; D017778:Vaccines, Combined