The CHIP28 water channel visualized in ice by electron crystallography.
Electron crystallography of frozen-hydrated two-dimensional crystals of deglycosylated human erythrocyte CHIP28 reveals an aqueous vestibule in each monomer leading to the water-selective channel that is enclosed by multiple transmembrane alpha-helices.
Mitra
A K
AK
van Hoek
A N
AN
Wiener
M C
MC
Verkman
A S
AS
Yeager
M
M
D002463:Cell Membrane Permeability; D003461:Crystallography / Q000379:methods*; D004583:Electrons; D004912:Erythrocytes / Q000737:chemistry / Q000378:metabolism; D005615:Freezing; D006031:Glycosylation; D006801:Humans; D007473:Ion Channels / Q000737:chemistry* / Q000378:metabolism; D017433:Protein Structure, Secondary; D014867:Water / Q000378:metabolism*
D007473:Ion Channels; D014867:Water