Activated T cells induce interleukin-12 production by monocytes via CD40-CD40 ligand interaction.
Previous studies on the production of interleukin-12 (IL-12) have shown that it is released, together with other proinflammatory cytokines, shortly after exposure of phagocytic cells to a variety of pathogens. We here report that IL-12 is also released during the recall response to soluble antigen (Ag) devoid of intrinsic adjuvant activity. We show that activated T cells induce the production of IL-12 by monocytes via a mechanism involving the interaction of T cell-associated CD40 ligand with CD40 on monocytes. The data suggest that Ag presentation on monocytes favors the persistence of type 1 responses.
Shu
U
U
University of Montreal, Notre-Dame Hospital Research Center, Quebec, Canada.
Kiniwa
M
M
Wu
C Y
CY
Maliszewski
C
C
Vezzio
N
N
Hakimi
J
J
Gately
M
M
Delespesse
G
G
D017951:Antigen Presentation; D015703:Antigens, CD / Q000276:immunology / Q000378:metabolism*; D000944:Antigens, Differentiation, B-Lymphocyte / Q000276:immunology / Q000378:metabolism*; D019013:CD40 Antigens; D002478:Cells, Cultured; D006801:Humans; D018664:Interleukin-12 / Q000096:biosynthesis*; D008213:Lymphocyte Activation; D009000:Monocytes / Q000276:immunology / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
D015703:Antigens, CD; D000944:Antigens, Differentiation, B-Lymphocyte; D019013:CD40 Antigens; D018664:Interleukin-12