Effects of ivermectin on the activity of enzymes in mammalian cells in vitro.
The effects of ivermectin on the activities of lactate dehydrogenase, glucose-6-phosphate dehydrogenase, and glucose-6-phosphatase have been estimated in IB-RS-2 cells in vitro. A 72-hr time course following ivermectin exposure indicated a decrease in the activity of lactate dehydrogenase. The activities of glucose-6-phosphate dehydrogenase and glucose-6-phosphatase remained essentially unchanged.
Mattei
R
R
Instituto Biológico, São Paulo, Brazil.
Rodrigues
M A
MA
D000818:Animals; D002460:Cell Line; D004305:Dose-Response Relationship, Drug; D005947:Glucose / Q000378:metabolism; D005952:Glucose-6-Phosphatase / Q000187:drug effects / Q000378:metabolism*; D005954:Glucosephosphate Dehydrogenase / Q000187:drug effects / Q000378:metabolism*; D007559:Ivermectin / Q000494:pharmacology* / Q000633:toxicity; D007770:L-Lactate Dehydrogenase / Q000187:drug effects / Q000378:metabolism*; D013552:Swine; D013997:Time Factors
D007559:Ivermectin; D007770:L-Lactate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005952:Glucose-6-Phosphatase; D005947:Glucose