title: [Neuron specific enolase-producing IgD multiple myeloma with high serum amylase activity].
abstract: A 68-year-old man who was admitted to our hospital because of general fatigue and anorexia. He was diagnosed as suffering from neuron specific enolase (NSE)-producing IgD-lambda type multiple myeloma with high activity of serum amylase, based on the detection of monoclonal IgD-lambda M-protein in the serum and urine, markedly high activities of salivary-type amylase and NSE in the serum, and immunohistochemical evidence of NSE and IgD in the myeloma cells. After two courses of alpha-IFN and VMCP chemotherapy, serum IgD, amylase and NSE decreased to normal levels. These observations indicate that NSE was ectopically produced by myeloma cells.
authors.affiliation: Japan Research Foundation for Chronic Diseases and Rehabilitation Affilated Hospital, Sakuragaoka Hospital.
authors.forename: T
authors.initials: T
authors.lastname: Nakajima
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Kumahara
authors.forename: A
authors.initials: A
authors.lastname: Sugihara
authors.forename: T
authors.initials: T
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Iwasaki
authors.forename: T
authors.initials: T
authors.lastname: Hamano
authors.forename: E
authors.initials: E
authors.lastname: Kakishita
mesh_terms: D000368:Aged; D000681:Amylases / Q000097:blood*; D006801:Humans; D007072:Immunoglobulin D / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008297:Male; D009101:Multiple Myeloma / Q000201:enzymology*; D010751:Phosphopyruvate Hydratase / Q000096:biosynthesis*
chemical_list: D007072:Immunoglobulin D; D007145:Immunoglobulin kappa-Chains; D000681:Amylases; D010751:Phosphopyruvate Hydratase