Turnover of circulating virion RNA and of cell-associated viral DNA reflects active viral replication in human immunodeficiency virus type 1-infected individuals.
A quantitative assessment of human immunodeficiency virus type 1 turnover in patient cell-free virion and infected-cell compartments under the dynamic conditions imposed by an effective antiviral therapy was performed. The turnover was rapid, and following a temporal lag, the extent of viral population replacement was eventually similar in both compartments. Each compartment therefore reflects considerable active virus replication.
Lineberger
D W
DW
Department of Antiviral Research, Merck Research Laboratories, West Point, Pennsylvania 19486.
Kessler
J A
JA
Waterbury
J A
JA
Byrnes
V W
VW
Massari
F
F
Staszewski
S
S
Emini
E A
EA
D000998:Antiviral Agents / Q000494:pharmacology; D001583:Benzoxazoles / Q000494:pharmacology; D002451:Cell Compartmentation; D002474:Cell-Free System; D004279:DNA, Viral / Q000378:metabolism*; D015658:HIV Infections / Q000821:virology*; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000201:enzymology / Q000235:genetics*; D006801:Humans; D011728:Pyridones / Q000494:pharmacology; D012367:RNA, Viral / Q000378:metabolism*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D018894:Reverse Transcriptase Inhibitors; D014771:Virion / Q000235:genetics*; D014779:Virus Replication / Q000235:genetics
D000998:Antiviral Agents; D001583:Benzoxazoles; D004279:DNA, Viral; D011728:Pyridones; D012367:RNA, Viral; D018894:Reverse Transcriptase Inhibitors; C076516:L-697661; D054303:HIV Reverse Transcriptase; D012194:RNA-Directed DNA Polymerase