[The clinical significance of interleukin-6 as an inflammatory marker (the studies in patients with open heart surgery)].
We analyzed serum levels of interleukin-6 (IL-6) and seven acute phase proteins in CRP positive samples and in patients with open heart surgery. The concentrations of serum IL-6 were not correlated with other acute phase proteins in CRP positive samples. However, IL-6 were in inverse correlation with CRP, AAG, AAT and CER in patients with open heart surgery. These discrepancies were due to the differences in response time of each acute phase protein after the start of inflammation. Responses of acute phase proteins after open heart surgery were investigated from hour to hour. IL-6 increased rather rapidly than other acute phase proteins, and increases of CRP, TRF, AAT, AAG, CER, HAP and AMG followed. The time reached the peak were IL-6, CRP, TRF, AAT, AMG, AAG, HAP reached the peak in that order. IL-6 constantly increased seven hours earlier, and reached at maximum values forty three hours earlier than CRP in each case. The measurement of serum concentration of IL-6 may be useful for early detection of acute inflammation.
Sakai
H
H
Department of Clinical Laboratory, National Cardiovascular Center Hospital, Suita.
Mori
K
K
Suzuki
K
K
Katayama
Y
Y
Matsuyama
T
T
D000208:Acute Disease; D000209:Acute-Phase Proteins / Q000032:analysis; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002097:C-Reactive Protein / Q000032:analysis; D006348:Cardiac Surgical Procedures; D005260:Female; D006801:Humans; D007249:Inflammation / Q000175:diagnosis*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged
D000209:Acute-Phase Proteins; D015415:Biomarkers; D015850:Interleukin-6; D002097:C-Reactive Protein