A role for CD5 in TCR-mediated signal transduction and thymocyte selection.
CD5 is a transmembrane protein that is expressed on the surface of T cells and a subset of B cells. The absence of CD5 rendered thymocytes hyperresponsive to stimulation through the T cell antigen receptor (TCR) in vitro. Selection of T cells expressing three distinct transgenic TCRs was also abnormal in CD5-deficient mice. These observations indicate that CD5 can influence the fate of developing thymocytes by acting as a negative regulator of TCR-mediated signal transduction.
Tarakhovsky
A
A
Institute for Genetics, University of Cologne, Germany.
Kanner
S B
SB
Hombach
J
J
Ledbetter
J A
JA
Müller
W
W
Killeen
N
N
Rajewsky
K
K
D000818:Animals; D015703:Antigens, CD / Q000276:immunology*; D017252:CD3 Complex / Q000378:metabolism; D018956:CD5 Antigens; D005260:Female; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008822:Mice, Transgenic; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D015398:Signal Transduction; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology; D051746:ZAP-70 Protein-Tyrosine Kinase
D015703:Antigens, CD; D017252:CD3 Complex; D018956:CD5 Antigens; D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases; D051746:ZAP-70 Protein-Tyrosine Kinase; C497262:Zap70 protein, mouse