Protein tyrosine kinase PYK2 involved in Ca(2+)-induced regulation of ion channel and MAP kinase functions.
The protein tyrosine kinase PYK2, which is highly expressed in the central nervous system, is rapidly phosphorylated on tyrosine residues in response to various stimuli that elevate the intracellular calcium concentration, as well as by protein kinase C activation. Activation of PYK2 leads to modulation of ion channel function and activation of the MAP kinase signalling pathway. PYK2 activation may provide a mechanism for a variety of short- and long-term calcium-dependent signalling events in the nervous system.
Lev
S
S
Department of Pharmacology, New York University Medical Center, New York 10016, USA.
Moreno
H
H
Martinez
R
R
Canoll
P
P
Peles
E
E
Musacchio
J M
JM
Plowman
G D
GD
Rudy
B
B
Schlessinger
J
J
D016475:3T3 Cells; D048868:Adaptor Proteins, Signal Transducing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000201:enzymology; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D003001:Cloning, Molecular; D017931:DNA Primers; D004789:Enzyme Activation; D051418:Focal Adhesion Kinase 2; D051380:GRB2 Adaptor Protein; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D007473:Ion Channels / Q000378:metabolism*; D051663:Kv1.2 Potassium Channel; D051379:Mice; D008969:Molecular Sequence Data; D016716:PC12 Cells; D010766:Phosphorylation; D015221:Potassium Channels / Q000378:metabolism; D024642:Potassium Channels, Voltage-Gated; D011493:Protein Kinase C / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000187:drug effects / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D014443:Tyrosine / Q000378:metabolism
D048868:Adaptor Proteins, Signal Transducing; D017931:DNA Primers; D051380:GRB2 Adaptor Protein; C495948:GRB2 protein, human; C495949:Grb2 protein, mouse; C495950:Grb2 protein, rat; D007473:Ion Channels; C496969:KCNA2 protein, human; C496970:Kcna2 protein, mouse; C496972:Kcna2 protein, rat; D051663:Kv1.2 Potassium Channel; D015221:Potassium Channels; D024642:Potassium Channels, Voltage-Gated; D011506:Proteins; D014443:Tyrosine; D011494:Protein Kinases; D011505:Protein-Tyrosine Kinases; D051418:Focal Adhesion Kinase 2; C496053:Ptk2b protein, mouse; C496054:Ptk2b protein, rat; D011493:Protein Kinase C; D019204:GTP-Binding Proteins; D002118:Calcium