[Value of local radiotherapy in treatment of osseous metastases, pathological fractures and spinal cord compression].
Local radiotherapy plays an important and responsible role in the management of bone metastases. The valence will be described according to the different treatment objectives in the sense of pain relief, remineralization and cord decompression. Radiotherapy schedules, aimed at the relief pain, need to take into consideration life expectancy. Patients with a reduced life expectancy could have a good high chance of achieving pain relief with a single dose of 8 Gy. Patients with a solitary metastasis, patients with a longer life expectancy and patients with a pathological fracture should be treated with 'curative' irradiation doses, aimed at killing the maximum number of tumor cells. In addition to pain relief, remineralization is also an important treatment goal. Conventional radiotherapy with doses of 40-50 Gy resulted in pain relief in 70-100% and in remineralization in 60-80% of the patients. Remineralization could not be accelerated by short-course fractionation courses, but resulted in faster pain relief. Short-course fractionation schedules are not indicated as a 'standard' treatment in the vertebral column. Surgery is the treatment of choice for immediate cord decompression and stabilization of a pathological vertebral fracture. Radiotherapy alone could decrease neurological impairment and is suitable for patients with gradual onset and progression of symptoms, no spinal instability and lesions of the cauda equina.
Eble
M J
MJ
Radiologische Universitätsklinik, Heidelberg.
Eckert
W
W
Wannenmacher
M
M
D001859:Bone Neoplasms / Q000532:radiotherapy / Q000556:secondary*; D005598:Fractures, Spontaneous / Q000532:radiotherapy*; D006801:Humans; D009460:Neurologic Examination / Q000528:radiation effects; D010166:Palliative Care; D011879:Radiotherapy Dosage; D011882:Radiotherapy, High-Energy; D013117:Spinal Cord Compression / Q000532:radiotherapy*; D013125:Spinal Neoplasms / Q000532:radiotherapy / Q000556:secondary*