Dehydroepiandrosterone modulates the spontaneous and IL-6 stimulated fibrinogen production of human hepatoma cells.
The role of an androgen, dehydroepiandrosterone (DHEA) has been studied on the constitutive and IL-6 induced fibrinogen production of HepG-2 cells. DHEA markedly augments the constitutive fibrinogen production of the hepatoma cells in a dose dependent fashion. Oppositely, for IL-6 induced fibrinogen production, DHEA is strongly inhibitory. The effectiveness of DHEA on the constitutive fibrinogen production is further potentiated if the hepatoma cells are preincubated with a glucocorticosteroid, dexamethasone. These findings demonstrate that the complex interaction between the steroid- and cytokine-directed regulation of the production of acute phase proteins is further coloured by the action of androgens on immune and hormonal systems.
Fehér
K G
KG
Department of Molecular Biology, National Institute of Rheumatology and Physiotherapy, Budapest, Hungary.
Rákász
E
E
Bíró
J
J
Falus
A
A
D006528:Carcinoma, Hepatocellular / Q000378:metabolism*; D003687:Dehydroepiandrosterone / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology; D005340:Fibrinogen / Q000096:biosynthesis*; D006801:Humans; D007155:Immunologic Factors / Q000494:pharmacology*; D015850:Interleukin-6 / Q000494:pharmacology*; D008113:Liver Neoplasms / Q000378:metabolism*; D011994:Recombinant Proteins / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D007155:Immunologic Factors; D015850:Interleukin-6; D011994:Recombinant Proteins; D003687:Dehydroepiandrosterone; D003907:Dexamethasone; D005340:Fibrinogen