Detection of acute infection/inflammation with Tc-99m labeled intact polyvalent human IgG.
Intact polyvalent human immune globulin (IgG) labeled with Tc-99m by a mild chemical method was investigated with animals infected with either S. aureus or E. coli in the thigh muscle. Focal infection was clearly visualized by Tc-99m IgG scintigraphy within 1 h postinjection. Tc-99m IgG appeared to be concentrated in the liver, spleen, kidneys and urinary bladder. It cleared rapidly via the kidneys resulting minimal of tissue background activity and high infection-to-normal organ ratios. At 24 h postinjection, the ratios of infectious lesion to blood, normal muscle and bone averaged 10:1, 23:1, and 24:1 for S. aureus infection vs 4:1, 9:1 and 9:1 for E. coli infection, respectively. Tc-99m labeled IgG also concentrated in terpentine-induced aseptic inflammatory lesion with a target-to-blood ratio of 4:1, bone 6:1 and normal muscle about 10:1. These findings suggest potential value of Tc-99m IgG as an imaging agent for the early detection of focal infection and inflammation.
Wong
D W
DW
Department of Radiology, Los Angeles County King-Charles R. Drew University of Sciences and Medicine, UCLA, School of Medicine 90059, USA.
Eisenman
J I
JI
Wade
W
W
D000818:Animals; D004926:Escherichia coli; D004927:Escherichia coli Infections / Q000000981:diagnostic imaging*; D006801:Humans; D007074:Immunoglobulin G; D007136:Immunoglobulins / Q000494:pharmacology; D007249:Inflammation; D008297:Male; D016719:Radioimmunodetection / Q000379:methods*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013203:Staphylococcal Infections / Q000000981:diagnostic imaging*; D013211:Staphylococcus aureus; D013667:Technetium / Q000494:pharmacology; D014018:Tissue Distribution
D007074:Immunoglobulin G; D007136:Immunoglobulins; C065376:technetium Tc 99m immunoglobulin; D013667:Technetium