Regulation of mouse and human mast cell development, survival and function by stem cell factor, the ligand for the c-kit receptor.
Stem cell factor (SCF), the ligand for the receptor (SCFR) that is encoded by the c-kit proto-oncogene, has many important effects in mouse and human mast cell development, survival, and function. SCF can promote mast cell survival by suppressing apoptosis, induce mast cell hyperplasia in murine rodents, experimental primates and humans, directly induce SCFR-dependent mast cell mediator release, and significantly modulate the extent of mast cell activation by Fc epsilon RI-dependent mechanisms. These findings raise several clinical issues and, in some cases, point to potentially significant therapeutic opportunities.
Galli
S J
SJ
Department of Pathology, Beth Israel Hospital, Boston, MA 02215, USA.
Tsai
M
M
Wershil
B K
BK
Tam
S Y
SY
Costa
J J
JJ
D000818:Animals; D017209:Apoptosis; D002470:Cell Survival; D016298:Hematopoietic Cell Growth Factors / Q000235:genetics / Q000502:physiology*; D006801:Humans; D006965:Hyperplasia; D008252:Macaca fascicularis; D008407:Mast Cells / Q000166:cytology*; D051379:Mice; D010215:Papio; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*; D019253:Proto-Oncogene Proteins c-bcl-2; D019009:Proto-Oncogene Proteins c-kit; D051381:Rats; D020794:Receptor Protein-Tyrosine Kinases / Q000502:physiology*; D016184:Receptors, Colony-Stimulating Factor / Q000502:physiology*; D017455:Receptors, IgE / Q000502:physiology; D019089:Stem Cell Factor
D016298:Hematopoietic Cell Growth Factors; C000715470:MAS1 protein, human; D000090063:Proto-Oncogene Mas; D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D016184:Receptors, Colony-Stimulating Factor; D017455:Receptors, IgE; D019089:Stem Cell Factor; D019009:Proto-Oncogene Proteins c-kit; D020794:Receptor Protein-Tyrosine Kinases