title: Somite differentiation. Sonic signals somites.
abstract: Sonic hedgehog, a secreted signalling molecule known to play a role in the patterning of the central nervous system and the limb in vertebrates, also controls differentiation of the somites.
authors.affiliation: Department of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.
authors.forename: D A
authors.initials: DA
authors.lastname: Bumcrot
authors.forename: A P
authors.initials: AP
authors.lastname: McMahon
mesh_terms: D000818:Animals; D002454:Cell Differentiation; D002642:Chick Embryo; D004627:Embryonic Induction / Q000502:physiology*; D005314:Embryonic and Fetal Development / Q000502:physiology; D053823:Hedgehog Proteins; D018398:Homeodomain Proteins / Q000502:physiology; D008648:Mesoderm / Q000166:cytology / Q000502:physiology*; D051379:Mice; D009024:Morphogenesis / Q000502:physiology*; D009672:Notochord / Q000502:physiology / Q000637:transplantation; D011506:Proteins / Q000502:physiology*; D015534:Trans-Activators; D014157:Transcription Factors / Q000502:physiology; D014714:Vertebrates / Q000196:embryology*
chemical_list: D053823:Hedgehog Proteins; D018398:Homeodomain Proteins; D011506:Proteins; D015534:Trans-Activators; D014157:Transcription Factors