[Effects of reducing injection on plasma TNF-alpha and IL-6 levels in rabbits with endotoxin-induced DIC].
Plasma TNF-a and IL-6 levels of endotoxin-induced DIC in rabbits were measured by ELISA methods. Simultaneously, the effects of Reduqing (RDQ) on TNF-alpha and IL-6 were also studied. The results showed that TNF-alpha and IL-6 levels increased markedly in model group, which were confirmed with obvious damage of tissue or organ. Co-administration of RDQ could reduce plasma TNF-alpha and IL-6 levels, together with mild tissue or organ damage. These results indicated TNF-alpha and IL-6 might be involved in pathogenesis of endotoxin-induced DIC, RDQ might be used in preventing or treating DIC through mechanism of reducing TNF-alpha and IL-6 levels.
Wu
C D
CD
Institute of Integrated Traditional and Western Medicine, Tongji Medical Univeristy, Wuhan.
Li
M Z
MZ
Zhang
Y P
YP
D000818:Animals; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000139:chemically induced; D004338:Drug Combinations; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D015850:Interleukin-6 / Q000097:blood*; D008070:Lipopolysaccharides; D008297:Male; D011817:Rabbits; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D004338:Drug Combinations; D004365:Drugs, Chinese Herbal; D015850:Interleukin-6; D008070:Lipopolysaccharides; D014409:Tumor Necrosis Factor-alpha