Pentoxifylline attenuates acute lung injury induced by microemboli.
Pentoxifylline (PTX), a methylxanthine derivative, effectively prevents acute lung injury in different animal models. To investigate whether PTX would attenuate acute lung injury induced by microemboli resulting from treatment with calcium chloride (CaCl2) suspension, an isolated blood-perfused rat lung model was used. Pretreatment with PTX prevented the increase in pulmonary arterial pressure (PAP), lung weight gain and protein concentration in the lavage fluid after CaCl2 treatment.
Shen
C Y
CY
Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan, Republic of China.
Hsu
K
K
Wang
D
D
Yan
H C
HC
D000208:Acute Disease; D000818:Animals; D001792:Blood Platelets / Q000502:physiology; D001794:Blood Pressure / Q000187:drug effects; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002122:Calcium Chloride / Q000633:toxicity*; D004617:Embolism / Q000188:drug therapy*; D008168:Lung / Q000473:pathology; D008171:Lung Diseases / Q000139:chemically induced*; D008297:Male; D009929:Organ Size; D010431:Pentoxifylline / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012128:Respiratory Distress Syndrome / Q000188:drug therapy; D014665:Vasodilator Agents / Q000627:therapeutic use*
D014665:Vasodilator Agents; D002122:Calcium Chloride; D010431:Pentoxifylline