Effects of theophylline on renal insufficiency in neonates with respiratory distress syndrome.
We report here 6 cases of critically ill newborn infants with both RDS and acute renal insufficiency, unresponsive to conventional treatment (furosemide, dopamine). Theophylline, an adenosine antagonist, has been shown to prevent hypoxemia-induced renal insufficiency in rabbits and our patients thus received compassionately a low-dose of theophylline (1 mg . kg-1 i.v.). Urinary water excretion and creatinine clearances increased significantly in 5 out of 6 neonates, thus suggesting a beneficial role of theophylline in neonatal prerenal failure.
Huet
F
F
Service de Pédiatrie 2, Hpital d'Enfants, CHRU de Dijon, France.
Semama
D
D
Grimaldi
M
M
Guignard
J P
JP
Gouyon
J B
JB
D058186:Acute Kidney Injury / Q000150:complications / Q000188:drug therapy*; D000241:Adenosine / Q000502:physiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007234:Infant, Premature; D007236:Infant, Small for Gestational Age; D008297:Male; D012127:Respiratory Distress Syndrome, Newborn / Q000150:complications*; D013806:Theophylline / Q000494:pharmacology / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
D014665:Vasodilator Agents; D013806:Theophylline; D000241:Adenosine