title: The tartrolons, new boron-containing antibiotics from a myxobacterium, Sorangium cellulosum.
abstract: New antibiotics were isolated from the culture broth of the myxobacterium, Sorangium cellulosum, strain So ce 678. The antibiotics were active against Gram-positive bacteria and mammalian cells. They were named tartrolon A and B. Tartrolon B contains a boron atom. The boron binding region of tartrolon is identical with that of boromycin and aplasmomycin.
authors.affiliation: GBF, Gesellschaft für Biotechnologische Forschung, Dept. of Biology of Natural Products, Braunschweig, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Irschik
authors.forename: D
authors.initials: D
authors.lastname: Schummer
authors.forename: K
authors.initials: K
authors.lastname: Gerth
authors.forename: G
authors.initials: G
authors.lastname: Höfle
authors.forename: H
authors.initials: H
authors.lastname: Reichenbach
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000494:pharmacology*; D001881:Borates / Q000378:metabolism / Q000494:pharmacology; D001896:Boron Compounds / Q000378:metabolism* / Q000494:pharmacology*; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004269:DNA, Bacterial / Q000096:biosynthesis / Q000187:drug effects; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000378:metabolism; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000378:metabolism; D007783:Lactones / Q000378:metabolism / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D009231:Myxococcales / Q000737:chemistry / Q000378:metabolism*; D012329:RNA, Bacterial / Q000096:biosynthesis / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects / Q000378:metabolism
chemical_list: D000900:Anti-Bacterial Agents; D001881:Borates; D001896:Boron Compounds; D004269:DNA, Bacterial; D007783:Lactones; D012329:RNA, Bacterial; C092169:tartrolon A; C092170:tartrolon B