Effect of maternal diabetes on longevity in offspring of spontaneously hypertensive rats.
We studied the effect of maternal diabetes induced by neonatal streptozotocin treatment on the longevity of the male offspring in spontaneously hypertensive rats (SHR). Maternal diabetes significantly decreased the survival in the offspring as compared with the control (p < 0.01). Mean age at death was 14.9 +/- 0.6 months in the offspring from the diabetic dams and 17.9 +/- 1.1 months in that from the control. The life span was significantly correlated with the birth weight (rs = 0.55, p = 0.009). These findings suggest that a diabetic pregnancy may accelerate an age-related degenerative process of the offspring in SHR.
Iwase
M
M
Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Wada
M
M
Shinohara
N
N
Yoshizumi
H
H
Yoshinari
M
M
Fujishima
M
M
D000818:Animals; D001724:Birth Weight; D001794:Blood Pressure; D003921:Diabetes Mellitus, Experimental / Q000150:complications* / Q000503:physiopathology*; D005314:Embryonic and Fetal Development; D005260:Female; D005317:Fetal Growth Retardation / Q000209:etiology / Q000503:physiopathology; D005951:Glucose Tolerance Test; D006973:Hypertension / Q000150:complications* / Q000503:physiopathology*; D008136:Longevity; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D011254:Pregnancy in Diabetics / Q000503:physiopathology*; D051381:Rats; D011918:Rats, Inbred SHR