Three isoforms of platelet-derived growth factors all have the capability to induce angiogenesis in vivo.
Three isoforms of platelet-derived growth factors (PDGFs) composing of AA, AB, and BB chains all exhibited angiogenic activity in a dose-dependent manner in an in vivo assay system involving the chorioallantoic membrane of chick embryo. The order of potency as BB > AB = AA. They, however, failed to stimulate proliferation of vascular endothelial cells, suggesting that their effects are indirect. These data suggest that possibility that three PDGF isoforms are indirect angiogenic factors.
Oikawa
T
T
Department of Cancer Therapeutics, Tokyo Metropolitan Institute of Medical Science, Japan.
Onozawa
C
C
Sakaguchi
M
M
Morita
I
I
Murota
S
S
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D007536:Isomerism; D009389:Neovascularization, Pathologic / Q000139:chemically induced* / Q000503:physiopathology; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects
D010982:Platelet-Derived Growth Factor