Neural recognition molecules in disease and regeneration.
The genetic analysis of inherited human diseases of the nervous system and the characterization of transgenic mice deficient in neural recognition molecules is opening up a new dimension in understanding the cellular and molecular mechanisms underlying neuro-developmental and -degenerative diseases, as well as in delineating the functions of recognition molecules in cell-cell interactions. Progress in identifying recognition molecules that inhibit neurite outgrowth and further characterization of the mechanisms that promote neurite outgrowth are shedding more light on the processes of regeneration in the mature nervous system. In the adult, recognition functions are fine-tuned by glycan moeities associated with neural recognition molecules, and successful neurite outgrowth is likely to depend on the delicate balance between growth-promoting and inhibitory recognition cues.
Schachner
M
M
Department of Neurobiology, Swiss Federal Institute of Technology, Zürich.
D000818:Animals; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology*; D006801:Humans; D051379:Mice; D008817:Mice, Mutant Strains / Q000378:metabolism; D009185:Myelin Proteins / Q000172:deficiency; D018992:Myelin-Associated Glycoprotein; D009416:Nerve Regeneration; D009422:Nervous System Diseases / Q000503:physiopathology*; D016501:Neurites / Q000502:physiology
D015816:Cell Adhesion Molecules, Neuronal; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein