title: [The first case of Sjögren's syndrome with anti-Wa antibody].
abstract: A 42-year-old woman presented in 1992 with Raynaud's phenomenon, polyarthralgia and morning stiffness and next year developed xerostomia and xerophthalmia. Investigations revealed 20 mm/hr of ESR, positive test for RAPA (1 : 320), ANF (1 : 1280), anti-SS-A antibody and anti-Wa antibody, and positive Schirmer tear test. A biopsied specimen of minor salivary gland of lip showed lymphocytic infiltration around the ducts and fibrotic changes and a sialogram demonstrated diffuse dilatations of the peripheral ducts. Resulting from the data shown above, the diagnosis of Sjögren's syndrome was made. Anti-Wa antibody, which recognizes a 48 kD tRNA associated protein was identified in serum from a patient with systemic sclerosis by Yamagata in 1985. So far the antibody has been specific for systemic sclerosis, because all of six patients with anti-Wa antibody previously reported were diagnosed as having systemic sclerosis. However, we here described the first case of Sjögren's syndrome with anti-Wa antibody.
authors.affiliation: Department of Internal Medicine, Miyazaki Prefectural Hospital.
authors.forename: A
authors.initials: A
authors.lastname: Ueda
authors.forename: S
authors.initials: S
authors.lastname: Higuchi
authors.forename: I
authors.initials: I
authors.lastname: Kikuchi
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Maehara
authors.forename: K
authors.initials: K
authors.lastname: Miyachi
mesh_terms: D000328:Adult; D001323:Autoantibodies / Q000032:analysis*; D005260:Female; D006801:Humans; D011928:Raynaud Disease / Q000209:etiology; D012859:Sjogren's Syndrome / Q000175:diagnosis / Q000276:immunology*
chemical_list: D001323:Autoantibodies