title: Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver.
abstract: In this article we demonstrate the immunocytochemical localization of nitric oxide synthase in non-synaptosomal rat brain mitochondria and rat liver mitochondria, using a monoclonal antibody directed against the endothelial form of nitric oxide synthase. The possibility that nitric oxide synthase located in mitochondria is involved in the regulation of mitochondrial oxidative phosphorylation is discussed.
authors.affiliation: Department of Neurochemistry, University of London, Queen Square, England.
authors.forename: T E
authors.initials: TE
authors.lastname: Bates
authors.forename: A
authors.initials: A
authors.lastname: Loesch
authors.forename: G
authors.initials: G
authors.lastname: Burnstock
authors.forename: J B
authors.initials: JB
authors.lastname: Clark
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000648:ultrastructure; D002118:Calcium / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000201:enzymology* / Q000648:ultrastructure; D008930:Mitochondria, Liver / Q000201:enzymology* / Q000648:ultrastructure; D019001:Nitric Oxide Synthase; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
chemical_list: D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D010100:Oxygen; D002118:Calcium