title: Soluble E-selectin and soluble tumour necrosis factor receptor (60 kD) serum levels in patients with psoriasis.
abstract: BACKGROUND
  Increased tumour necrosis factor alpha has been found in psoriatic skin. This cytokine activates endothelial cells and induces the membrane E-selectin molecule (E-selectin or endothelial leucocyte adhesion molecule 1); the same cytokine is able to induce its own receptors. Since the soluble forms of E-selectin and tumour necrosis factor receptor (TNF-R, 60 kD) may be reliably measured in body fluids, these determinations have been performed in the sera of psoriatic patients.
  
  
  OBJECTIVE
  To evaluate endothelial activation in psoriatic patients, sE-selectin has been determined in patient sera and compared with those of a control group. sTNF-R (60 kD) was also measured in the same samples.
  
  
  METHODS
  Two commercially available enzyme immunoassay methods have been used to determine sE-selectin and sTNF-R (60 kD) in the sera of 19 patients with plaque-type psoriasis; 22 healthy subjects were used as controls.
  
  
  CONCLUSIONS
  Significantly increased amounts of sE-selectin serum levels were found in psoriatic patients as compared to healthy controls. Moreover, a direct correlation between sE-selectin and PASI scores was observed. On the contrary, sTNF-R (60 kD) serum levels presented no increases. These data suggest that sE-selectin serum levels are a reliable marker of disease activity in psoriatic patients.
authors.affiliation: IIIrd Department of Dermatology, San Gallicano Institute, Roma, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Bonifati
authors.forename: E
authors.initials: E
authors.lastname: Trento
authors.forename: M
authors.initials: M
authors.lastname: Carducci
authors.forename: G
authors.initials: G
authors.lastname: Sacerdoti
authors.forename: A
authors.initials: A
authors.lastname: Mussi
authors.forename: M
authors.initials: M
authors.lastname: Fazio
authors.forename: F
authors.initials: F
authors.lastname: Ameglio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D015815:Cell Adhesion Molecules / Q000097:blood*; D019040:E-Selectin; D005260:Female; D006801:Humans; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood; D008875:Middle Aged; D011565:Psoriasis / Q000097:blood* / Q000473:pathology; D011971:Receptors, Immunologic / Q000032:analysis*; D018124:Receptors, Tumor Necrosis Factor / Q000032:analysis*; D012995:Solubility
chemical_list: D015415:Biomarkers; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D018124:Receptors, Tumor Necrosis Factor