Erythrocyte antigens as immunogenetic markers of respiratory atopic diseases in Georgians.
The aim of this study was to investigate the role of erythrocyte antigens of several systems (ABO, Rh, MNSs, P, Duffy, Kell) in the predisposition to and development of respiratory atopic disease (RAD) in the Georgian population. Two hundred and ninety-three patients with RAD, 83 patients with intrinsic bronchial asthma (IBA) and 215 healthy subjects were included. Associations between blood groups and RAD (atopic bronchial asthma [ABA] and pollinosis), the severity of the disease and the type of sensitization were established, involving the ABO, MNSs and Duffy systems. The groups at higher risk for the development of RAD were carriers of phenotypes O(I), MN, O(I)MN, MNFya(-), O(I)Fya(-) and O(I)MNFya(-). Resistance to RAD was associated with phenotypes A(II), AB(IV), N, Fya(+) and B(III)N. Markers for ABA and pollinosis were also revealed. Allergy to house dust allergen was associated with phenotype MN, whereas pollen sensitization was associated with the M group of MNSs. The risk for the development of severe ABA was higher in patients with B(III), M and B(III)M phenotypes. For the patients with groups O(I) and MN, a mild to moderate degree of severity of ABA was more characteristic. In healthy Georgians, erythrocyte polymorphism was not associated with immune status. In cases of house dust allergy, erythrocyte antigen P1 was associated with high levels of IgE. In patients with RAD higher B-lymphocyte counts were associated with O(I) and lower counts with A(II).
Khetsuriani
N G
NG
Department of Allergology, Tbilisi Medical University, Georgia.
Gamkrelidze
A G
AG
D001249:Asthma / Q000235:genetics / Q000276:immunology; D001789:Blood Group Antigens / Q000235:genetics* / Q000276:immunology*; D005819:Genetic Markers / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics / Q000276:immunology; D012130:Respiratory Hypersensitivity / Q000235:genetics / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000235:genetics / Q000276:immunology; D012426:Russia / Q000208:ethnology
D001789:Blood Group Antigens; D005819:Genetic Markers