Salicylaldoxime blocks K+ and Ca2+ currents in rat cardiac myocytes.
The effects of salicylaldoxime, 2-(OH)C6H4CH = NOH, on the action potential duration, transient outward K+ current and slow inward Ca2+ current were studied in isolated rat ventricular myocytes. The application of salicylaldoxime (0.1-2.0 mM) reversibly increased the action potential duration and reduced in a dose-dependent manner both the transient outward K+ and the slow inward Ca2+ currents. The effect of salicylaldoxime on these two ionic currents was similar to that of 2,3-butanedione monoxime, but was about ten times more potent. Compounds which block both K+ and Ca2+ currents may represent a new type of Class III antiarrhythmic agent which counteracts arrhythmias initiated by re-entry with reduced proarrhythmic risk via triggered activity.
Karhu
S
S
Department of Physiology, University of Oulu, Finland.
Perttula
S
S
Weckström
M
M
Kivistö
T
T
Sellin
L C
LC
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000166:cytology; D010091:Oximes / Q000494:pharmacology*; D026902:Potassium Channel Blockers; D051381:Rats
D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D010091:Oximes; D026902:Potassium Channel Blockers; C005704:salicylaldoxime