Transformation of fibroblasts into endothelial cells during angiogenesis.
Light- and electron-microscopic autoradiography have been used to study fibroblast transformation into endothelial cells in the formation of new blood vessels during wound healing in rabbit ear chambers. When cultured fibroblasts labeled with tritium thymidine were transplanted autologously into the chambers, newly formed blood vessels contained endothelial cells labeled with tritium thymidine. This result suggests that fibroblasts play a pivotal role in angiogenesis, as progenitors of endothelial cells in newly formed blood vessels.
Kon
K
K
Department of Medical Laboratory Technology, Ehime College of Health Science, Japan.
Fujiwara
T
T
D000818:Animals; D001345:Autoradiography; D002454:Cell Differentiation; D017690:Cell Transplantation; D002478:Cells, Cultured; D004423:Ear / Q000098:blood supply; D004730:Endothelium, Vascular / Q000166:cytology* / Q000648:ultrastructure; D005347:Fibroblasts / Q000166:cytology* / Q000637:transplantation; D008854:Microscopy, Electron; D009389:Neovascularization, Pathologic; D011817:Rabbits; D014945:Wound Healing