title: Formation of membrane channels by chrysospermins, new peptaibol antibiotics.
abstract: The four homologous chrysospermins (Ia-d) are new 19 amino acid peptaibols which form cation selective ion channels in artificial lipid bilayer membranes. Conductance of channels formed by chrysospermins B (Ib) and D (Id) was twice as high (640 pS in 100 mM KCl) as found with chrysospermins A (Ia) and C (Ic). Single channel current traces were recorded for each of the four peptides even at very low (even zero) membrane voltages suggesting that non-gated channels are formed.
authors.affiliation: Hans-Knöll-Institute of Natural Product Research, Jena, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Grigoriev
authors.forename: R
authors.initials: R
authors.lastname: Schlegel
authors.forename: K
authors.initials: K
authors.lastname: Dornberger
authors.forename: U
authors.initials: U
authors.lastname: Gräfe
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D005658:Fungi / Q000737:chemistry; D007473:Ion Channels / Q000187:drug effects*; D008567:Membranes, Artificial; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000494:pharmacology*
chemical_list: D000596:Amino Acids; D000900:Anti-Bacterial Agents; D007473:Ion Channels; D008567:Membranes, Artificial; D009842:Oligopeptides