title: Late results of mitral valve replacement with Carpentier-Edwards high profile bioprosthesis in young adults.
abstract: Carpentier-Edwards (C/E) high profile supra-annular porcine bioprostheses were implanted in 163 patients between September 1982-February 1987 in the mitral position due to rheumatic disease. The patients' ages ranged between 15 and 58 years (mean: 36.5 +/- 11.5). One hundred-two of the patients (62.5%) were female. The hospital mortality was 9.8% (16/163). The total cumulative follow-up period was 1093 patient-years (p-y) with a mean of 7.3 +/- 3.5 p-y (range 6 months-12 years). Linearised occurrence rates of the late complications were as follows: Thromboembolism 0.82%/p-v, anticoagulant-related bleeding 1.0%/p-y, prosthetic valve endocarditis 0.09%/p-y. Actuarial survival rates for 5 and 12 years were 87% +/- 6% and 76% +/- 9%, respectively, with 95% confidence limits. Freedom from structural deterioration was 92% +/- 5% for 5 years and 44% +/- 11% for 12 years. Freedom from all valve-related complications was 81% +/- 7 for 5 years and 26% +/- 9 for 12 years. In conclusion, this prosthesis provides satisfactory clinical performance in young population despite the high risk of degeneration with good prognosis and better tolerability of reoperation.
authors.affiliation: Department of Cardiovascular Surgery, Türkiye Yüksek Ihthisas Hospital, Ankara, Turkey.
authors.forename: B
authors.initials: B
authors.lastname: Yamak
authors.forename: E
authors.initials: E
authors.lastname: Sener
authors.forename: U
authors.initials: U
authors.lastname: Kiziltepe
authors.forename: B
authors.initials: B
authors.lastname: Mavitas
authors.forename: O
authors.initials: O
authors.lastname: Tasdemir
authors.forename: K
authors.initials: K
authors.lastname: Bayazit
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D001705:Bioprosthesis / Q000009:adverse effects / Q000401:mortality; D004697:Endocarditis, Bacterial / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000401:mortality / Q000601:surgery; D006350:Heart Valve Prosthesis / Q000009:adverse effects / Q000401:mortality; D006801:Humans; D008297:Male; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D011379:Prognosis; D016459:Prosthesis-Related Infections / Q000209:etiology; D012214:Rheumatic Heart Disease / Q000401:mortality / Q000601:surgery*; D015996:Survival Rate; D013923:Thromboembolism / Q000209:etiology