Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina.
The effects of photoreceptor cell degeneration on the expression of nine alpha-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/kainate glutamate receptor subunit genes were investigated in the rd mouse retina by in situ hybridization. All known AMPA/kainate receptor subunits were found to be expressed in normal mouse retina. Following retinal degeneration, the expression of KA-1 was reduced, that of the GluR7 subunit was greatly increased, and that of the other seven subunits were not significantly affected.
Duvoisin
R M
RM
Margaret M. Dyson Vision Research Institute, Department of Ophthalmology, Cornell University Medical College, New York, NY 10021, USA.
Zhang
C
C
Hamassaki-Britto
D E
DE
Britto
L R
LR
D000818:Animals; D015870:Gene Expression; D017403:In Situ Hybridization; D007608:Kainic Acid / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D009410:Nerve Degeneration; D010786:Photoreceptor Cells / Q000473:pathology; D017470:Receptors, Glutamate / Q000145:classification* / Q000235:genetics; D012160:Retina / Q000473:pathology*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology
D017470:Receptors, Glutamate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D007608:Kainic Acid