title: Serum lipoprotein profile in Algerian patients with celiac disease.
abstract: Celiac disease is characterized by a gluten-induced villous atrophy of the upper small intestine which has an active role in the lipoprotein metabolism. In the present study the lipoprotein profiles of different patients were analyzed to determine the effect of impaired enterocyte function in celiac disease. We compared serum lipid parameters in controls and in celiac disease patients. The major differences between celiac disease patients and the control group were a diminution of cholesterol and phospholipids in HDL and LDL in the former. These differences persisted after treatment; in addition, a lower level of cholesterol in VLDL was observed. Plasma LpAI and apo A-I levels were significantly lower (-17 and -15%) in celiac disease patients than in controls. Both levels remained low after gluten-free diet. In Algerian patients, treatment with gluten-free diet did not give any return towards normal lipids concentrations.
authors.affiliation: Université d'Es-Sérna, Oran, Algeria.
authors.forename: S
authors.initials: S
authors.lastname: Médiène
authors.forename: S
authors.initials: S
authors.lastname: Hakem
authors.forename: J M
authors.initials: JM
authors.lastname: Bard
authors.forename: I
authors.initials: I
authors.lastname: Medjaoui
authors.forename: S
authors.initials: S
authors.lastname: Benhamamouch
authors.forename: P
authors.initials: P
authors.lastname: Lebel
authors.forename: J C
authors.initials: JC
authors.lastname: Fruchart
authors.forename: V
authors.initials: V
authors.lastname: Clavey
mesh_terms: D000293:Adolescent; D000328:Adult; D000462:Algeria / Q000453:epidemiology; D001053:Apolipoproteins / Q000097:blood; D002446:Celiac Disease / Q000097:blood* / Q000178:diet therapy / Q000453:epidemiology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D001053:Apolipoproteins; D008055:Lipids; D008074:Lipoproteins