[New diagnostic developments in infection serology].
New developments concerning the diagnostic of virus-transmitted diseases led to a strong improvement of virus security in hemotherapy. The introduction of additional virus antigens associated with the core region of the hepatitis C virus (HCV) resulted in an increase of sensitivity and especially of specificity of second-generation enzyme immuno assays (EIAs). The recombinant immunoblot (RIBA) with 4 synthetic antigens continues to be the most accepted confirmatory test in the field of HCV diagnostic. Beside the simultaneous detection of specific IgG and IgM, especially the HIV-p24 antigen test is discussed concerning HIV-1, -2 diagnostic in order to shorten the 'windows period' in the early time of infection. It is assumed that the HIV-p24 antigen test is not able to effectively improve virus security in areas with low HIV-1, -2 prevalence.
Sibrowski
W
W
Institut für Transfusionsmedizin, Westfälischen Wilhelms-Universität, Münster.
Brauer
P
P
D015492:AIDS Serodiagnosis / Q000379:methods; D017848:Blood-Borne Pathogens; D015483:HIV Antibodies / Q000097:blood; D015488:HIV Antigens / Q000097:blood; D015497:HIV-1 / Q000276:immunology; D015498:HIV-2 / Q000276:immunology; D006508:Hepatitis Antibodies / Q000097:blood; D006526:Hepatitis C / Q000276:immunology / Q000517:prevention & control / Q000635:transmission; D018937:Hepatitis C Antibodies; D006801:Humans; D012698:Serologic Tests / Q000379:methods*; D014777:Virus Diseases / Q000276:immunology / Q000517:prevention & control* / Q000635:transmission
D015483:HIV Antibodies; D015488:HIV Antigens; D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies