title: Anastomotic breaking strength and healing of anastomoses in rat intestine with and without chronic radiation damage.
abstract: OBJECTIVE
  To assess the influence of chronic radiation damage on anastomotic healing in the small bowel in rats.
  
  
  METHODS
  Controlled laboratory study.
  
  
  METHODS
  University hospital, Sweden.
  
  
  METHODS
  90 male Sprague-Dawley rats.
  
  
  METHODS
  A short segment of the distal ileum was exteriorised and irradiated with a single dose (experimental group, n = 45) or exposed only (control group, n = 45). Twenty weeks later resection and anastomosis were done within this segment using 7/0 polypropylene.
  
  
  METHODS
  The anastomotic breaking strength, the amount of perianastomotic hydroxyproline, and the number of anastomotic complications.
  
  
  RESULTS
  The breaking strength and the amount of perianastomotic hydroxyproline were higher in the irradiated than in the non-irradiated group. In contrast, anastomotic complications were significantly more common in irradiated animals.
  
  
  CONCLUSIONS
  Anastomotic complications in irradiated intestine are not related to the amount of perianastomotic collagen or to breaking strength.
authors.affiliation: Department of Urology, Orebro Medical Center, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Jahnson
authors.forename: W
authors.initials: W
authors.lastname: Graf
authors.forename: G
authors.initials: G
authors.lastname: Rikner
authors.forename: B
authors.initials: B
authors.lastname: Gerdin
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D006909:Hydroxyproline / Q000378:metabolism; D007082:Ileum / Q000528:radiation effects* / Q000601:surgery*; D008297:Male; D011833:Radiation Injuries, Experimental; D051381:Rats; D017207:Rats, Sprague-Dawley; D013718:Tensile Strength; D014945:Wound Healing / Q000528:radiation effects*
chemical_list: D006909:Hydroxyproline