Inhibition of nitric oxide synthase partially attenuates alterations in the blood-cerebrospinal fluid barrier during experimental meningitis in the rat.
The permeability of the blood-cerebrospinal fluid (blood-CSF) barrier is increased upon exposure to lipopolysaccharides during bacterial meningitis. Lipopolysaccharides induce nitric oxide (NO) synthase in a variety of cells. Increased meningeal NO production and blood-CSF barrier permeability were observed in a rat model of meningitis. Administration of aminoguanidine, an inhibitor of NO synthase, blocked meningeal NO production and significantly attenuated permeability changes in the blood-CSF barrier. It is hypothesized that pathological production of NO may contribute to the disruption of the blood-CSF barrier during meningitis.
Boje
K M
KM
Department of Pharmaceutics, School of Pharmacy, University of Buffalo, NY 14260, USA.
D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D002555:Cerebrospinal Fluid / Q000378:metabolism*; D006146:Guanidines / Q000494:pharmacology; D008297:Male; D016920:Meningitis, Bacterial / Q000378:metabolism*; D009569:Nitric Oxide / Q000502:physiology; D019001:Nitric Oxide Synthase; D010539:Permeability; D051381:Rats; D017207:Rats, Sprague-Dawley
D006146:Guanidines; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; C004479:pimagedine