title: Intrathymic and extrathymic clonal deletion of T cells.
abstract: Clonal elimination accounts for self-tolerance induction in the thymus and also affects mature T cells responding to exogenous antigens in the periphery. Recent evidence on the microenvironments, cell-cell interactions and signalling requirements for clonal deletion of immature and mature T cells is discussed.
authors.affiliation: Department of Immunology, Scripps Research Institute, La Jolla, CA 92037, USA.
authors.forename: J
authors.initials: J
authors.lastname: Sprent
authors.forename: S R
authors.initials: SR
authors.lastname: Webb
mesh_terms: D000818:Animals; D017637:Clonal Deletion / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D013950:Thymus Gland / Q000276:immunology*