Trolox protects mitochondrial complex IV from nitric oxide-mediated damage in astrocytes.
The efficacy of cystine, ascorbate and trolox, a vitamin E analogue, at protecting against nitric oxide-mediated mitochondrial complex IV damage has been investigated in cultured astrocytes. Of these compounds, only trolox afforded protection. It is suggested that lipid peroxidation is responsible for nitric oxide-mediated mitochondrial damage and that inhibitors of this process may be of therapeutic benefit in conditions where excessive nitric oxide production is implicated.
Heales
S J
SJ
Department of Neurochemistry, Institute of Neurology, London, UK.
Bolaños
J P
JP
Land
J M
JM
Clark
J B
JB
D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis*; D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology; D001253:Astrocytes / Q000187:drug effects / Q000201:enzymology / Q000648:ultrastructure*; D002839:Chromans / Q000494:pharmacology*; D003553:Cystine / Q000494:pharmacology; D003576:Electron Transport Complex IV / Q000187:drug effects* / Q000378:metabolism; D004790:Enzyme Induction; D007371:Interferon-gamma / Q000008:administration & dosage; D015227:Lipid Peroxidation; D008070:Lipopolysaccharides / Q000494:pharmacology; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D009569:Nitric Oxide / Q000009:adverse effects*; D019001:Nitric Oxide Synthase; D051381:Rats; D017208:Rats, Wistar; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000037:antagonists & inhibitors*
D002839:Chromans; D008070:Lipopolysaccharides; D009569:Nitric Oxide; D003553:Cystine; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D007371:Interferon-gamma; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D003576:Electron Transport Complex IV; D001205:Ascorbic Acid; C010643:6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid