[The relationship between P-selectin on platelet membrane and platelet function in chronic cor pulmonale].
Platelet plays an important role in thromboembolic diseases. It is demonstrated that recurrent pulmonary embolism may cause pulmonary hypertention. In recent years, P-selectin (granule membrane protein, GMP140) was found to be a surface marker for platelet activation. In order to investigate the role of platelet in chronic cor pulmonale, the changes of P-selectin on platelet membrane and its effect on platelet adhesiveness (PAdT) and platelet aggregation (PAgT) were studied. The results showed that the changes of P-selectin PAdT and PAgT in chronic cor pulmonale were significant than those in chronic pulmonary diseases and controls (P < 0.01). There was positive correlation between P-selectin and PAdT (r = 0.6831, P < 0.01) as well as PAgT (r = 0.7142, P < 0.01). The levels of von Willebrand factor (vWF) and fibrinogen (Fg) were markedly increased in chronic cor pulmonale as compared with chronic pulmonary disease and control group (P < 0.01). There was also positive correlation between vWF and PAgT (r = 0.4143, P < 0.05) as well as between Fg and PAgT (r = 0.4392, P < 0.05). It is concluded that platelet plays an important role in the pathogenesis of chronic cor pulmonale.
Yu
H
H
Department of Respiratory Diseases, Zhu Jiang Hospital, First Military Medical University, Guanzhou.
Liu
L
L
Wang
J
J
D000368:Aged; D000911:Antibodies, Monoclonal; D001792:Blood Platelets / Q000502:physiology*; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006801:Humans; D008297:Male; D008875:Middle Aged; D019007:P-Selectin; D010973:Platelet Adhesiveness; D010974:Platelet Aggregation; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism*; D011660:Pulmonary Heart Disease / Q000097:blood*; D014841:von Willebrand Factor / Q000378:metabolism
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins; D014841:von Willebrand Factor; D005340:Fibrinogen