title: HLA antigens in five Amerindian groups (Yuko, Bari, Tunebo, Guane and Paez) of Colombia: results of 'Expedición Humana'.
abstract: The serological HLA types (A, B, C and D loci) were studied in five different Indian groups in Colombia. The range of polymorphism was not very restricted in these groups, but there was significant genetic heterogeneity among the five populations in all the HLA loci. The gene frequency data, when converted into a kinship matrix and a two-dimensional eigen vector plot, showed a closer affinity between Bari and Yuko Indians, while Guane, Tunebo and Paez Indians were not only genetically different from the former but also well-differentiated from each other. It seems therefore from this study that geographical proximity may play a greater role than linguistic similarities in the genetic affinities of Colombian Amerindians.
authors.affiliation: Institute of Human Genetics, Medical School, Universidad Javeriana, Bogotá Colombia.
authors.forename: J E
authors.initials: JE
authors.lastname: Bernal
authors.forename: C
authors.initials: C
authors.lastname: Duran
authors.forename: I
authors.initials: I
authors.lastname: Briceno
authors.forename: J
authors.initials: J
authors.lastname: Ortega
authors.forename: S S
authors.initials: SS
authors.lastname: Papiha
mesh_terms: D000940:Antigenic Variation; D003105:Colombia; D005787:Gene Frequency; D006680:HLA Antigens / Q000235:genetics*; D015234:HLA-A Antigens / Q000235:genetics; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006681:HLA-D Antigens / Q000235:genetics; D006650:Histocompatibility Testing; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D008285:Major Histocompatibility Complex / Q000235:genetics*; D011110:Polymorphism, Genetic
chemical_list: D006680:HLA Antigens; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D006681:HLA-D Antigens