Effects of postnatal aluminum exposure on biological parameters in the rat plasma.
Young rats were treated by gastric intubation with aluminum chloride (100 mg Al/kg/day) and aluminum lactate (100 and 200 mg Al/kg/day) from postnatal days 5 to 14. This treatment lead to a reduction in body weight. The plasma concentrations of total proteins and albumin decreased whereas the alpha 1 globulins increased in the treated rats. The aluminum concentrations in plasma and hepatic homogenates increased particularly at 200 mg Al lactate. The reduction in average body weight could be attributed to various causes: a decreased food consumption, a transient undernutrition, a reduction of the protein synthesis in the liver. The increase of the plasma concentration of the alpha 1 globulins revealed an inflammation process.
Cherroret
G
G
Centre des Sciences de l'Environement (Neurotoxicologie), Université de Metz, France.
Capolaghi
B
B
Hutin
M F
MF
Burnel
D
D
Desor
D
D
Lehr
P R
PR
D000284:Administration, Oral; D000510:Alpha-Globulins / Q000378:metabolism; D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000097:blood / Q000633:toxicity*; D000818:Animals; D000831:Animals, Newborn; D001798:Blood Proteins / Q000187:drug effects* / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D002712:Chlorides / Q000097:blood / Q000633:toxicity*; D007773:Lactates / Q000097:blood / Q000633:toxicity*; D019344:Lactic Acid; D008099:Liver / Q000737:chemistry; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000187:drug effects / Q000378:metabolism
D000510:Alpha-Globulins; D017607:Aluminum Compounds; D001798:Blood Proteins; D002712:Chlorides; D007773:Lactates; D012709:Serum Albumin; D019344:Lactic Acid; D000077410:Aluminum Chloride