title: Spindle cell lipomas. A report of two cases: one with multiple lesions.
abstract: BACKGROUND
  Spindle cell lipoma is an unusual and histologically distinctive form of lipoma occurring primarily in older individuals.
  
  
  OBJECTIVE
  The dermatologic surgeon and pathologist should be familiar with this variant of lipoma.
  
  
  METHODS
  We are reporting two cases of spindle cell lipomas with the results of histologic examination with special stains and immunohistochemical studies.
  
  
  RESULTS
  The neoplasms consisted of lobulated masses of mature adipose tissue with areas of spindle cell proliferation. There was strong positive staining with antibodies for vimentin within the areas of spindle cells proliferation. One of the cases is unusual in that multiple lesions are occurring in a young patient.
  
  
  CONCLUSIONS
  Recognition of the histologic pattern is important in distinguishing the benign spindle cell lipoma from the malignant liposarcoma.
authors.affiliation: Pinkus Dermatopathology Laboratory, Monroe, Michigan 48161, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Mehregan
authors.forename: D A
authors.initials: DA
authors.lastname: Mehregan
authors.forename: A H
authors.initials: AH
authors.lastname: Mehregan
authors.forename: M A
authors.initials: MA
authors.lastname: Dorman
authors.forename: E
authors.initials: E
authors.lastname: Cohen
mesh_terms: D000273:Adipose Tissue / Q000473:pathology; D000293:Adolescent; D002455:Cell Division; D003094:Collagen / Q000032:analysis; D003937:Diagnosis, Differential; D006801:Humans; D007150:Immunohistochemistry; D008067:Lipoma / Q000473:pathology*; D008080:Liposarcoma / Q000473:pathology; D008297:Male; D008875:Middle Aged; D012878:Skin Neoplasms / Q000473:pathology*; D012983:Soft Tissue Neoplasms / Q000473:pathology*; D013194:Staining and Labeling; D014746:Vimentin / Q000032:analysis
chemical_list: D014746:Vimentin; D003094:Collagen