Cell death in normo- and teratogenesis. I. Cell death in normogenesis.
This first part of the review deals with the main facts and problems related to the role of cell death in normal prenatal development. After an overview of the pioneering work in this field, the essential contributions brought during the last few decades are presented, with special stress upon the contribution brought by the team of the Laboratory of Embryology and Teratology, Timişoara. The morphology of cell death is analysed based upon the classification of Schweichel and Merker (1973). Finally, a detailed account is given on the recent, impressive advance with respect to molecular and molecular-genetic mechanisms underlying and determining the cell death process.
Sandor
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Laboratory of Embryology and Teratology, Timişoara, Romania.
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D000818:Animals; D016923:Cell Death / Q000502:physiology*; D000013:Congenital Abnormalities / Q000503:physiopathology*; D005314:Embryonic and Fetal Development / Q000502:physiology*; D006801:Humans; D012016:Reference Values