Production and function of IL-10 in the central nervous system.
Our data suggest an important regulatory role for IL-10 within the central nervous system by a) reducing the antigenpresenting capacity of astro- and microglia and thereby lowering or preventing, antigen-specific proliferative T cell responses, and b) inhibition of inflammatory cytokine production by the resident parenchymal cells as well as from infiltrating monocytes/macrophages. In the latter instance the signals triggering cytokine production are crucial since IL-10 interferes with bacterial but not viral or cytokine-induced activation of expression of cytokine genes.
Frei
K
K
Dept of Internal Medicine, University Hospital, Häldeliweg, Zürich.
Lins
H
H
Fontana
A
A
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology*; D001253:Astrocytes / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology; D001921:Brain / Q000276:immunology*; D002648:Child; D016207:Cytokines / Q000378:metabolism; D006801:Humans; D016753:Interleukin-10 / Q000502:physiology*; D008213:Lymphocyte Activation / Q000276:immunology; D008264:Macrophages / Q000276:immunology; D016920:Meningitis, Bacterial / Q000276:immunology; D051379:Mice; D017628:Microglia / Q000276:immunology*; D009000:Monocytes / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D016207:Cytokines; D016753:Interleukin-10