NMDA receptor involvement in endothelin neurotoxicity in rat striatal slices.
The high K(+)-evoked dopamine release from rat striatal slices remained impaired by 50% up to 2 h after pulse exposure of the tissues to endothelin-3, under conditions of hypoglycemia/hypoxia. This striatal dysfunction was significantly improved by D-2-amino-5-phosphonopentanoic acid, a NMDA receptor antagonist, at a much lower concentration than that providing protection against NMDA-evoked dysfunction. In light of these findings, the important role of glutamatergic mechanisms, especially NMDA receptors, in mediating endothelin neurotoxicity warrants further attention.
Kataoka
Y
Y
Department of Pharmacology 2, Nagasaki University School of Medicine, Japan.
Koizumi
S
S
Kohzuma
M
M
Shibaguchi
H
H
Shigematsu
K
K
Niwa
M
M
Taniyama
K
K
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester / Q000633:toxicity; D000818:Animals; D004298:Dopamine / Q000378:metabolism; D016232:Endothelins / Q000633:toxicity*; D066298:In Vitro Techniques; D008297:Male; D016202:N-Methylaspartate / Q000633:toxicity; D017072:Neostriatum / Q000166:cytology* / Q000187:drug effects / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000378:metabolism; D009543:Nifedipine / Q000494:pharmacology; D011188:Potassium / Q000494:pharmacology; D011189:Potassium Chloride / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects*
D016232:Endothelins; D016194:Receptors, N-Methyl-D-Aspartate; D016202:N-Methylaspartate; D011189:Potassium Chloride; D001498:3-Pyridinecarboxylic acid, 1,4-dihydro-2,6-dimethyl-5-nitro-4-(2-(trifluoromethyl)phenyl)-, Methyl ester; D015763:2-Amino-5-phosphonovalerate; D009543:Nifedipine; D011188:Potassium; D004298:Dopamine