title: Carbamazepine treatment for cocaine dependence.
abstract: We report on a double-blind, placebo-controlled study of carbamazepine (CBZ) treatment for cocaine dependence. A previously reported uncontrolled study found CBZ to be a beneficial pharmacotherapy for cocaine dependence. Statistical analyses were performed on data from 82 subjects who were randomized to 10 weeks' treatment with either CBZ, titrated to 4-12 micrograms/ml, (n = 37) or placebo (n = 45). The two treatment groups did not differ for primary outcome measures of retention time in treatment, urine samples positive for cocaine metabolite, subject reported desire for cocaine or for subject reported side-effects. CBZ was not an effective treatment in this study.
authors.affiliation: Department of Psychiatry, University of Pennsylvania, Philadelphia 19104, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Cornish
authors.forename: I
authors.initials: I
authors.lastname: Maany
authors.forename: P J
authors.initials: PJ
authors.lastname: Fudala
authors.forename: S
authors.initials: S
authors.lastname: Neal
authors.forename: S A
authors.initials: SA
authors.lastname: Poole
authors.forename: P
authors.initials: P
authors.lastname: Volpicelli
authors.forename: C P
authors.initials: CP
authors.lastname: O'Brien
mesh_terms: D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D003042:Cocaine / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009294:Narcotics; D015813:Substance Abuse Detection; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D009294:Narcotics; D002220:Carbamazepine; C005618:benzoylecgonine; D003042:Cocaine