Intravenous immunoglobulin infusion in multifocal demyelinating motor neuropathy: a case report.
The following report is a case of multifocal demyelinating motor neuropathy (MMN) presenting as a gradual development of asymmetric motor weakness without sensory involvement. Electrophysiological studies showed mainly a conduction block with normal or slightly slow nerve conduction velocity. Cerebrospinal fluid (CSF) protein and serum protein electrophoresis were normal, but serum IgM anti-GM1 ganglioside antibody was elevated. The patient had a poor response to steroid, plasmapheresis and chemotherapy with cyclophosphamide, but significant improvement was noted after intravenous immunoglobulin (IVIG) infusion. MMN is a potentially treatable condition which clinically mimics a motor neuron disease; if treatment with steroid, plasmapheresis and cyclophosphamide have failed, IVIG may be effective.
Lin
Y Y
YY
Neurological Institute, Veterans General Hospital-Taipei, Taiwan, R.O.C.
Tsai
C P
CP
Ting
Y C
YC
Lin
K P
KP
Liao
K K
KK
Kao
K P
KP
Wang
S J
SJ
D003711:Demyelinating Diseases / Q000276:immunology / Q000628:therapy*; D005677:G(M1) Ganglioside / Q000276:immunology; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D016472:Motor Neuron Disease / Q000276:immunology / Q000628:therapy*
D016756:Immunoglobulins, Intravenous; D005677:G(M1) Ganglioside