Polymethylene spacer linked bis(Ala) peptides form modified beta-sheet structures. Crystal structure and self-assembly pattern of adipoyl and suberoyl analogues.
The adipoyl- and suberoyl-linked bis(Ala) peptides have an extended backbone between the two C alpha atoms in each molecule. They self-assemble, through intermolecular hydrogen bonds and stacking of parallel strands, into highly ordered modified beta-sheet-like structures. Crystals data for adipoyl bis(Ala)diester are as follows: C14H24N2O6, monoclinic space group P2(1), a = 4.900(1), b = 29.093(10), c = 6.021(2) A, beta = 104.20(2) degrees, R = 0.053 for 1100 data > 3 sigma (F); for suberoyl bis(Ala)diester: C16H28N2O6, monoclinic space group P2(1), a = 4.887(2), b = 32.650(9), c = 6.004(2) A, beta = 103.79(3), R = 0.070 for 1065 data > 3 sigma (F).
Karle
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Laboratory for the Structure of Matter, Naval Research Laboratory, Washington, DC, USA.
Ranganathan
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D000272:Adipates / Q000737:chemistry; D000409:Alanine / Q000737:chemistry*; D002210:Caprylates; D018360:Crystallography, X-Ray; D003652:Decanoic Acids / Q000737:chemistry; D003998:Dicarboxylic Acids / Q000737:chemistry; D005977:Glutarates / Q000737:chemistry; D010070:Oxalates / Q000737:chemistry; D019815:Oxalic Acid; D010455:Peptides / Q000737:chemistry*; D011487:Protein Conformation; D017433:Protein Structure, Secondary; D013386:Succinates / Q000737:chemistry; D019802:Succinic Acid
D000272:Adipates; D002210:Caprylates; D003652:Decanoic Acids; D003998:Dicarboxylic Acids; D005977:Glutarates; D010070:Oxalates; D010455:Peptides; D013386:Succinates; C005738:suberic acid; C029900:adipic acid; C011107:sebacic acid; D019815:Oxalic Acid; D019802:Succinic Acid; C035736:glutaric acid; D000409:Alanine