Rho as a regulator of the cytoskeleton.
Many cell functions, including maintenance of morphology, aggregation, motility, membrane ruffling, smooth-muscle contraction, cytokinesis in mammals and bud formation in yeast, are regulated through the dynamic reorganization of actin filaments. Although it has long been known that Ca2+ is a key regulator of the cytoskeleton, evidence is now accumulating that Rho, a Ras-related small GTP-binding protein, is another important regulator of these actin-dependent cell functions.
Takai
Y
Y
Department of Molecular Biology and Biochemistry, Osaka University Medical School, Japan.
Sasaki
T
T
Tanaka
K
K
Nakanishi
H
H
D000209:Acute-Phase Proteins / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D017434:Protein Structure, Tertiary
D000209:Acute-Phase Proteins; C010781:acute-phase protein rho