title: C-terminal amino groups facilitate membrane incorporation of gramicidin derivatives.
abstract: Gramicidin derivatives with (positively-charged) C-terminal amino groups are found to incorporate readily and refold quickly when added to dioleoylphosphatidylcholine lipid vesicles from concentrated methanol solutions. Neutral and negatively-charged derivatives do not.
authors.affiliation: Department of Chemistry, University of Toronto, Canada.
authors.forename: D C
authors.initials: DC
authors.lastname: Jaikaran
authors.forename: Z
authors.initials: Z
authors.lastname: Zhang
authors.forename: G A
authors.initials: GA
authors.lastname: Woolley
mesh_terms: D002942:Circular Dichroism; D006096:Gramicidin / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry; D017510:Protein Folding; D013329:Structure-Activity Relationship
chemical_list: D010713:Phosphatidylcholines; D006096:Gramicidin; C017251:1,2-oleoylphosphatidylcholine