title: Changes in serum levels of IGF-I and IGFBP-3 in children with chronic renal failure.
abstract: The significance of serum insulin-like growth factor I (IGF-I) and insulin-like growth factor binding protein 3 (IGFBP-3) levels in uremia is still controversial. In this study we measured serum IGF-I by immunoradiometric assay (IRMA) and IGFBP-3 levels by specific radioimmunoassay (RIA) in 28 children (aged 3-16 years) with end-stage (n = 14, on hemodialysis) and pre-terminal renal failure (n = 14) and in 15 age-matched healthy children. Thyroid function of the patients was also investigated and GH-stimulation tests with L-Dopa and insulin were performed. Neither IGF-I nor IGFBP-3 levels significantly correlated with mean height SDS for bone age or for chronological age in either non dialysis patients or pubertal (n = 10) or prepubertal patients (n = 18). These data was consistent with the concept that growth in CRF was not related to abnormalities in serum IGF-I or IGFBP-3 levels.
authors.affiliation: Gazi University, Faculty of Medicine, Turkey.
authors.forename: N
authors.initials: N
authors.lastname: Buyan
authors.forename: P
authors.initials: P
authors.lastname: Cinaz
authors.forename: E
authors.initials: E
authors.lastname: Hasanoğlu
authors.forename: N
authors.initials: N
authors.lastname: Gökçora
authors.forename: Z
authors.initials: Z
authors.lastname: Bircan
mesh_terms: D000293:Adolescent; D002352:Carrier Proteins / Q000097:blood*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006130:Growth Disorders / Q000209:etiology; D006801:Humans; D015592:Immunoradiometric Assay; D007328:Insulin; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D007676:Kidney Failure, Chronic / Q000097:blood* / Q000150:complications / Q000503:physiopathology; D007980:Levodopa; D008297:Male; D011863:Radioimmunoassay; D006435:Renal Dialysis; D013961:Thyroid Gland / Q000503:physiopathology
chemical_list: D002352:Carrier Proteins; D007328:Insulin; D018969:Insulin-Like Growth Factor Binding Proteins; D007980:Levodopa; D007334:Insulin-Like Growth Factor I