title: [RAEB in T with monosomy 7 after treatment of severe aplastic anemia with long term G-CSF].
abstract: A 19-year-old male who suffered from severe aplastic anemia had been treated with granulocyte colony stimulating factor (G-CSF) from September 1991. Marked increase of hematopoietic cells in his bone marrow was observed, and maintenance administration of G-CSF was continued. 15 months later, myeloblasts with nuclear abnormality increased, and 22 months later, myeloblasts with chromosomal abnormality presenting 46, XY, -7, +21 exceeded 20%, and aplastic anemia seemed to be transformed into refractory anemia with excess of blasts in transformation (RAEB in T). The usefulness of G-CSF in the treatment of aplastic anemia is now established, but there are some reports questioning the effect of long-term administration, especially transformation to MDS with monosomy 7. Leukemic transformation from aplastic anemia is very complex, but in some cases, long term administration of G-CSF may affect the natural course and may lead to the earlier development of leukemia.
authors.affiliation: Second Department of Internal Medicine, Jikei University School of Medicine.
authors.forename: K
authors.initials: K
authors.lastname: Kaito
authors.forename: H
authors.initials: H
authors.lastname: Otsubo
authors.forename: Y
authors.initials: Y
authors.lastname: Ogasawara
authors.forename: T
authors.initials: T
authors.lastname: Sekita
authors.forename: A
authors.initials: A
authors.lastname: Saeki
authors.forename: K
authors.initials: K
authors.lastname: Nishiwaki
authors.forename: H
authors.initials: H
authors.lastname: Masuoka
authors.forename: T
authors.initials: T
authors.lastname: Shimada
authors.forename: M
authors.initials: M
authors.lastname: Kobayashi
authors.forename: O
authors.initials: O
authors.lastname: Sakai
mesh_terms: D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy*; D000754:Anemia, Refractory, with Excess of Blasts / Q000209:etiology* / Q000235:genetics*; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D009006:Monosomy
chemical_list: D016179:Granulocyte Colony-Stimulating Factor