title: Transurethral balloon laser hyperthermia for chronic non-bacterial prostatitis: a clinical trial.
abstract: Transurethral balloon laser hyperthermia (TUBAL-H) was performed on five patients with chronic non-bacterial prostatitis who failed to respond to conventional treatment administered for more than two years. The prostatic interstitial temperature during treatment was measured and the safety and efficacy of this treatment was assessed. TUBAL-H was performed at a target temperature of 43 degrees C (5 mm depth) and at a laser power of 30 watts with urethral cooling for 20 min in the first three patients and for 30 min in the remaining two patients. The prostatic interstitial temperature at a depth of about 5 mm from the urethral surface ranged from 40.5 to 43.0 degrees C during treatment. The temperature of the urethra ranged from 31.5 to 39 degrees C and that of the rectum remained below 39.5 degrees C. After treatment, no abnormal findings were noted in any of the hematological and biological tests carried out, including prostatic specific antigen. The leukocyte count in expressed prostatic secretions fell to less than five cells per high-power field in four of the five patients after three months. A complete improvement in symptoms was observed in one patient, partial improvement in three, and no improvement in one. Based on these results, TUBAL-H was considered to be safe and a suitable treatment for patients with chronic prostatitis.
authors.affiliation: Department of Urology, Gunma University School of Medicine, Maebashi, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Kurokawa
authors.forename: K
authors.initials: K
authors.lastname: Suzuki
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Yamanaka
mesh_terms: D000328:Adult; D000368:Aged; D001831:Body Temperature; D002404:Catheterization; D002908:Chronic Disease; D006801:Humans; D006979:Hyperthermia, Induced / Q000379:methods*; D053685:Laser Therapy; D008297:Male; D008875:Middle Aged; D009929:Organ Size; D011467:Prostate / Q000473:pathology / Q000503:physiopathology; D017430:Prostate-Specific Antigen / Q000097:blood; D011472:Prostatitis / Q000473:pathology / Q000503:physiopathology / Q000628:therapy*; D014521:Urethra
chemical_list: D017430:Prostate-Specific Antigen