The international standard for granulocyte colony stimulating factor (G-CSF). Evaluation in an international collaborative study. Participants of the Collaborative Study.
Three ampouled preparations of granulocyte colony stimulating factor (G-CSF) have been evaluated by 29 laboratories in 11 countries for their suitability to serve as international standards for these materials. The preparations were assayed in a wide range of in vitro bioassays and immunoassays. On the basis of results reported here with the agreement of the participants in the study and with the authorisation of the Expert Committee on Biological Standardization (ECBS) of the World Health Organization (WHO) one of the preparations (88/502) was established as the international standard for G-CSF.
Mire-Sluis
A R
AR
Division of Immunobiology, National Institute for Biological Standards and Control, Potters Bar, Herts, UK.
Das
R G
RG
Thorpe
R
R
D001681:Biological Assay; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002455:Cell Division / Q000187:drug effects; D002460:Cell Line; D004355:Drug Stability; D004797:Enzyme-Linked Immunosorbent Assay; D016179:Granulocyte Colony-Stimulating Factor / Q000032:analysis* / Q000494:pharmacology / Q000592:standards*; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology; D011994:Recombinant Proteins / Q000592:standards; D012015:Reference Standards; D014944:World Health Organization
D007375:Interleukin-1; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor