title: Quantitative EEG characteristics of children exposed in utero to cocaine.
abstract: Quantitative EEGs (QEEGs) were evaluated in a group of 6 school age children with in utero cocaine exposure. Their QEEGs showed significant deviations from age expected normal values. Further, the QEEG profile of brain dysfunction seen in these children was extremely similar to that previously reported in a large population of crack cocaine dependent adults. These abnormalities were characterized by significant excess of relative power in the alpha frequency band, and deficits of absolute and relative power in the delta and theta bands. Characteristic disturbances in interhemispheric relationships were also present. The similarities between the QEEG profiles of those adults with chronic exposure and children with prenatal exposure suggests that the brain dysfunction reflected in the QEEG is not a result of a transient change in neurotransmission, but a more profound alteration which persists in these children at school age. Further study is required to extend these findings to a larger group of children, and to investigate the potential relationship between these neurophysiological abnormalities and the developmental, behavioral and co-morbid features observed in such children.
authors.affiliation: Brain Research Laboratories, NYU Medical Center, NY 10016, USA.
authors.forename: L S
authors.initials: LS
authors.lastname: Prichep
authors.forename: S C
authors.initials: SC
authors.lastname: Kowalik
authors.forename: K
authors.initials: K
authors.lastname: Alper
authors.forename: C
authors.initials: C
authors.lastname: de Jesus
mesh_terms: D000328:Adult; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D002648:Child; D002653:Child Behavior Disorders / Q000139:chemically induced* / Q000503:physiopathology; D003042:Cocaine / Q000009:adverse effects*; D016578:Crack Cocaine / Q000009:adverse effects*; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects*; D005260:Female; D005583:Fourier Analysis; D006801:Humans; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012815:Signal Processing, Computer-Assisted; D019966:Substance-Related Disorders / Q000503:physiopathology
chemical_list: D016578:Crack Cocaine; D003042:Cocaine