title: Reciprocal expression of co-stimulatory molecules, B7-1 and B7-2, on murine T cells following activation.
abstract: The co-stimulatory B7 molecules (B7-1 and B7-2) are expressed on professional antigen-presenting cells in mice. In this study, we demonstrate that B7-1 (CD80) and B7-2 (CD86) are also expressed on murine T cells in the absence of major histocompatibility complex class II molecules. The temporal expression of these two molecules on T cells varies with the state of activation where resting T cells express B7-2 but show little or no expression of B7-1. Following activation, B7-2 expression is down-regulated and there is a concomitant increase in the expression of B7-1 on the cell surface which peaks at about 72 h. Thus these two co-stimulatory molecules are reciprocally expressed on the T cell surface. This pattern of expression of B7-1 and B7-2 on T cells suggests that these two molecules may have different roles in the generation and regulation of immune responses.
authors.affiliation: Center for Neurologic Diseases, Brigham and Women's Hospital, Boston, MA 02115.
authors.forename: M R
authors.initials: MR
authors.lastname: Prabhu Das
authors.forename: S S
authors.initials: SS
authors.lastname: Zamvil
authors.forename: F
authors.initials: F
authors.lastname: Borriello
authors.forename: H L
authors.initials: HL
authors.lastname: Weiner
authors.forename: A H
authors.initials: AH
authors.lastname: Sharpe
authors.forename: V K
authors.initials: VK
authors.lastname: Kuchroo
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD; D018122:B7-1 Antigen / Q000096:biosynthesis*; D051940:B7-2 Antigen; D002999:Clone Cells; D005260:Female; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D008213:Lymphocyte Activation / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000096:biosynthesis*; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018122:B7-1 Antigen; D051940:B7-2 Antigen; C497965:Cd86 protein, mouse; D008562:Membrane Glycoproteins; D004676:Myelin Basic Protein