The macrophage, TNF, and other cytokines.
A complex interplay of peptides known as the cytokines may have a tremendous influence over a number of inflammatory related conditions. Tumor necrosis factor occupies an early and central role in the initiation of cascades that ultimately influences a number of cell types involved in tissue inflammation, tissue rejection, cancer, and injuries from ischemia reperfusion. Only now are the cascades being defined and therapies being designed to interrupt the toxic effects of these cytokines and to treat malignancy.
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Section of Thoracic Oncology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA.
Mew
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Temeck
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D000818:Animals; D000855:Anorexia / Q000209:etiology; D002986:Clinical Trials as Topic; D003115:Colony-Stimulating Factors / Q000502:physiology; D006224:Cricetinae; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000502:physiology* / Q000627:therapeutic use; D006084:Graft Rejection / Q000209:etiology; D006331:Heart Diseases / Q000209:etiology; D006801:Humans; D007167:Immunotherapy; D066298:In Vitro Techniques; D007372:Interferons / Q000502:physiology; D007378:Interleukins / Q000502:physiology; D007938:Leukemia / Q000628:therapy; D008264:Macrophages / Q000502:physiology*; D051379:Mice; D009369:Neoplasms / Q000503:physiopathology / Q000628:therapy; D012128:Respiratory Distress Syndrome / Q000209:etiology; D012772:Shock, Septic / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology* / Q000627:therapeutic use
D003115:Colony-Stimulating Factors; D016207:Cytokines; D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha; D007372:Interferons