Effect of recombinant human erythropoietin on the switchover from fetal to adult hemoglobin synthesis in preterm infants.
To determine whether recombinant erythropoietin (r-HuEpo) administered to very low birth weight infants could increase hemoglobin F synthesis, or delay its developmentally programmed decline, we determined serially the synthesis of hemoglobins A and F in 15 preterm infants receiving either a placebo or r-HuEpo. There was no difference between the two groups in the proportion of hemoglobin F being synthesized in relation to postconceptional age.
Bard
H
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Department of Pediatrics, University of Montreal, Hôpital Ste. Justine, Quebec, Canada.
Widness
J A
JA
D000704:Analysis of Variance; D004311:Double-Blind Method; D004921:Erythropoietin / Q000008:administration & dosage / Q000494:pharmacology*; D005319:Fetal Hemoglobin / Q000032:analysis / Q000096:biosynthesis / Q000187:drug effects*; D006441:Hemoglobin A / Q000032:analysis / Q000096:biosynthesis / Q000187:drug effects*; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D012156:Reticulocytes / Q000187:drug effects / Q000378:metabolism; D013997:Time Factors
D011994:Recombinant Proteins; D004921:Erythropoietin; D006441:Hemoglobin A; D005319:Fetal Hemoglobin