title: [Monocytoid B-lymphocyte lymphoma: a new type within the spectrum of non-Hodgkin's B-cell lymphoma].
abstract: BACKGROUND
  Clonal proliferation of monocytoid B-lymphocytes (MBLy)--monocytoid B-cell lymphoma (MBCL) represents a "new" type of lymphoma within the spectrum of B-cell malignancies.
  
  
  OBJECTIVE
  The aim of the study was to evaluate the possibilities of a routine histological and immunohistochemical diagnosis of MBCL.
  
  
  METHODS
  Three cases of MBCL diagnosed in peripheral lymph nodes (n = 2) and in mammary gland with infiltration of regional lymph node (n = 1) were analyzed both histologically and immunohistochemically using a panel approach (Ig chains, CD30 antigen, markers of B-cells, T-cells and of monocytes/histiocytes).
  
  
  RESULTS
  Morphological appearance of neoplastic cells of MBCL is identical to that of MBLy in reactive conditions--kidney-shaped nuclei, bright clear PAS-negative cytoplasm, and small inconspicuous nucleoli.
  
  
  CONCLUSIONS
  Morphological appearance together with immunophenotypic results (positivity of CD20 and Ki-B5, negativity of CD3, CD43, CD45RO, and of lysozyme, negativity of CD30) are considered to represent sufficient diagnostic criteria of MBCL, including its differential diagnosis of other B-cell low grade malignancies. An increase of large cell type MBLy might represent a feature of a secondary blastic transformation of MBCL. (Tab. 2, Fig. 5, Ref. 27.)
authors.affiliation: Institute of Pathology, Jessenius School of Medicine, Comenius University, Martin, Slovakia.
authors.forename: L
authors.initials: L
authors.lastname: Plank
authors.forename: L
authors.initials: L
authors.lastname: Sokol
authors.forename: M
authors.initials: M
authors.lastname: Adamkov
authors.forename: P
authors.initials: P
authors.lastname: Szépe
authors.forename: E
authors.initials: E
authors.lastname: Pokorná
authors.forename: J
authors.initials: J
authors.lastname: Strachilová
authors.forename: J
authors.initials: J
authors.lastname: Ocková
authors.forename: S
authors.initials: S
authors.lastname: Sekerková
authors.forename: R
authors.initials: R
authors.lastname: Balková
mesh_terms: D000368:Aged; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000145:classification / Q000473:pathology; D008297:Male; D008875:Middle Aged