Relationship between staining by digital subtraction angiography and vascularity in breast cancer: analysis of the time-density curve and the results of staining for factor VIII-related antigen/von Willebrand factor.
We performed intravenous digital subtraction angiography (IV-DSA) in 31 patients with primary invasive breast cancer, and calculated the maximum density of tumor staining from the time-density curve obtained. Specimens resected from the same patients were stained for factor VIII-related antigen/von Willebrand factor (vWF), and the amount of microvessels was calculated by image processing. A significant correlation (correlation coefficient: 0.85) was found between the maximum density of tumor staining and the vascularity determined by staining for vWF, indicating that the maximum density indirectly reflects the vascularity in the tumor.
Watanabe
O
O
Department of Surgery, Tokyo Women's Medical College Daini Hospital, Japan.
Haga
S
S
Shimizu
T
T
Imamura
H
H
Kobayashi
K
K
Kinoshita
J
J
Kajiwara
T
T
Fujibayashi
M
M
D015901:Angiography, Digital Subtraction; D001943:Breast Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000276:immunology; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000276:immunology; D005260:Female; D006801:Humans; D008833:Microcirculation; D013194:Staining and Labeling; D014841:von Willebrand Factor / Q000032:analysis*
D014841:von Willebrand Factor