title: Cepacidine A, a novel antifungal antibiotic produced by Pseudomonas cepacia. II. Physico-chemical properties and structure elucidation.
abstract: Cepacidine A is a novel glycopeptide with a potent antifungal activity, which is produced by Pseudomonas cepacia AF 2001. Its molecular weight was determined by FAB-MS (m/z 1215). The compound is comprised of glycine (1), serine (2), 2,4-diaminobutyric acid (1), aspartic acid (1), beta-hydroxy tyrosine (1), beta-hydroxy asparagine (1), xylose (1) and 5,7-dihydroxy-3,9-diamino-octadecanoic acid (1). Unfortunately, cepacidine A is a mixture of A1 and A2, either of which is barely distinguishable. Cepacidine A2 includes asparagine (1) instead of beta-hydroxy asparagine (1) of cepacidine A1. The MS data and the NOESY, TOCSY and HMBC spectra show that cepacidine A is a cyclic peptide and xylose is connected to 5,7-dihydroxy-3,9-diaminooctadecanoic acid.
authors.affiliation: R&D Center, Cheil Foods & Chemicals Inc., Kyunggi-Do, South Korea.
authors.forename: Y
authors.initials: Y
authors.lastname: Lim
authors.forename: J W
authors.initials: JW
authors.lastname: Suh
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: B
authors.initials: B
authors.lastname: Hyun
authors.forename: C
authors.initials: C
authors.lastname: Kim
authors.forename: C H
authors.initials: CH
authors.lastname: Lee
mesh_terms: D000900:Anti-Bacterial Agents / Q000737:chemistry*; D000935:Antifungal Agents / Q000737:chemistry*; D016956:Burkholderia cepacia / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010455:Peptides; D016339:Spectrometry, Mass, Fast Atom Bombardment
chemical_list: D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D010455:Peptides; C091813:cepacidine A