title: A 6-month home-usage trial of 0.1% and 0.2% delmopinol mouthwashes (II). Effects on the plaque microflora.
abstract: The effects of 0.1% and 0.2% delmopinol mouthwashes on supragingival plaque flora were investigated in a 6-month home-use study. 141 subjects were studied from whom plaque was collected at baseline, 12, 24, and 36 weeks. Overall, there were no consistent effects on microscopic or total counts. However, there was a significant reduction in the proportion of dextran-producing streptococci in the active groups compared to the control group throughout treatment. There was no colonisation by Candida or Gram-negative aerobic bacilli in the active groups nor was there any decrease in susceptibility to delmopinol. Delmopinol appears to mediate its anti-plaque effect without causing a major shift in bacterial populations, although dextran-producing bacteria appear to be affected, which may have relevance to this agent's mode of action.
authors.affiliation: Department of Periodontology, Dental School, University of Wales College of Medicine, Health Park, Cardiff, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: Elworthy
authors.forename: R
authors.initials: R
authors.lastname: Edgar
authors.forename: J
authors.initials: J
authors.lastname: Moran
authors.forename: M
authors.initials: M
authors.lastname: Addy
authors.forename: R
authors.initials: R
authors.lastname: Movert
authors.forename: E
authors.initials: E
authors.lastname: Kelty
authors.forename: W G
authors.initials: WG
authors.lastname: Wade
mesh_terms: D000293:Adolescent; D000328:Adult; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D001419:Bacteria / Q000187:drug effects* / Q000302:isolation & purification; D001420:Bacteria, Aerobic / Q000187:drug effects / Q000302:isolation & purification; D002175:Candida / Q000187:drug effects / Q000302:isolation & purification; D015169:Colony Count, Microbial; D003773:Dental Plaque / Q000382:microbiology*; D003911:Dextrans / Q000378:metabolism; D016967:Fusobacterium nucleatum / Q000187:drug effects / Q000302:isolation & purification; D006090:Gram-Negative Bacteria / Q000187:drug effects / Q000302:isolation & purification; D006801:Humans; D008875:Middle Aged; D009025:Morpholines / Q000008:administration & dosage / Q000627:therapeutic use*; D009067:Mouthwashes; D009910:Oral Hygiene; D018713:Prevotella intermedia / Q000187:drug effects / Q000302:isolation & purification; D013291:Streptococcus / Q000187:drug effects / Q000302:isolation & purification / Q000378:metabolism; D013501:Surface-Active Agents / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D000891:Anti-Infective Agents, Local; D003911:Dextrans; D009025:Morpholines; D009067:Mouthwashes; D013501:Surface-Active Agents; C073738:delmopinol