title: Granulosa cell tumor in an ovariohysterectomized dog.
abstract: A granulosa cell tumor was found in a dog with clinical signs of persistent estrus that began 6 years after ovariohysterectomy had been performed. The tumor was diagnosed by use of ultrasonography, provocative testing with human chorionic gonadotropin, and exploratory laparotomy. Hyperestrogenism from functional tumor cells caused bone marrow suppression and endocrine alopecia. Successful treatment included tumor removal, blood transfusions, and antibiotic administration.
authors.affiliation: Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman 99164-6610, USA.
authors.forename: G E
authors.initials: GE
authors.lastname: Pluhar
authors.forename: M A
authors.initials: MA
authors.lastname: Memon
authors.forename: L G
authors.initials: LG
authors.lastname: Wheaton
mesh_terms: D000818:Animals; D006063:Chorionic Gonadotropin; D004283:Dog Diseases / Q000175:diagnosis* / Q000209:etiology / Q000601:surgery; D004285:Dogs; D004958:Estradiol / Q000097:blood; D005260:Female; D006106:Granulosa Cell Tumor / Q000175:diagnosis / Q000209:etiology / Q000601:surgery / Q000662:veterinary*; D007044:Hysterectomy / Q000662:veterinary; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000209:etiology / Q000601:surgery / Q000662:veterinary*; D010052:Ovariectomy / Q000662:veterinary; D011183:Postoperative Complications / Q000662:veterinary; D011374:Progesterone / Q000097:blood; D012086:Reoperation / Q000662:veterinary
chemical_list: D006063:Chorionic Gonadotropin; D011374:Progesterone; D004958:Estradiol