title: Fluconazole treatment of candida peritonitis with delayed removal of the peritoneal dialysis catheter.
abstract: Candida peritonitis was treated with fluconazole in ten continuous ambulatory peritoneal dialysis (CAPD) patients without immediate removal of the peritoneal catheter. Shortly prior to diagnosis, six patients (60%) had received broad-spectrum antibiotics. Gram stain of peritoneal fluid detected yeast in 70% of cases. In eight patients the peritoneal dialysis catheter was removed within one week of diagnosis because of clinical deterioration. In the majority of cases (90%), candida peritonitis resolved only after catheter removal in spite of ongoing fluconazole therapy. Fluconazole was well tolerated by all patients.
authors.affiliation: Division of Nephrology, Hospital de Galdakao, Vizcaya, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Montenegro
authors.forename: R
authors.initials: R
authors.lastname: Aguirre
authors.forename: O
authors.initials: O
authors.lastname: González
authors.forename: I
authors.initials: I
authors.lastname: Martinez
authors.forename: R
authors.initials: R
authors.lastname: Saracho
mesh_terms: D000935:Antifungal Agents / Q000627:therapeutic use*; D002177:Candidiasis / Q000188:drug therapy* / Q000453:epidemiology / Q000209:etiology*; D002408:Catheters, Indwelling / Q000009:adverse effects; D005260:Female; D015725:Fluconazole / Q000627:therapeutic use*; D006801:Humans; D007676:Kidney Failure, Chronic / Q000628:therapy; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010538:Peritonitis / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology*; D012307:Risk Factors; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D015725:Fluconazole