title: Combined radiochemotherapy for postoperative recurrence of oesophageal cancer.
abstract: Postoperative recurrences are common after resection for oesophageal cancer. From January 1986 to September 1993 31 patients (30 males, one female, mean (SD) age: 57.5 (8.8) years) were treated for locoregional recurrence (n = 24), metastases (n = 6) or both (n = 1) occurring 15.0 (12.6) months after initial surgery. Radiotherapy and chemotherapy were combined in all cases. Symptomatic improvement was seen in 23 cases (74%) and lasted (excluding treatment period) for 6.3 (4) months. Objective tumoral response was seen in 20 patients (65%) including eight (26%) complete responses. Survival rates were at respectively six months, one, two, and three years: 70.7%, 47.1%, 17.1%, 4.3%. In conclusion, these results show that combined therapy could have a beneficial symptomatic effect and can be associated with prolonged survival in patients with postoperative recurrences of oesophageal cancer.
authors.affiliation: Centre F. Marquis, Rennes, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Raoul
authors.forename: E
authors.initials: E
authors.lastname: Le Prisé
authors.forename: B
authors.initials: B
authors.lastname: Meunier
authors.forename: V
authors.initials: V
authors.lastname: Julienne
authors.forename: P L
authors.initials: PL
authors.lastname: Etienne
authors.forename: M
authors.initials: M
authors.lastname: Gosselin
authors.forename: B
authors.initials: B
authors.lastname: Launois
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000532:radiotherapy*; D002945:Cisplatin / Q000627:therapeutic use; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D005260:Female; D005472:Fluorouracil / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy* / Q000532:radiotherapy*; D015996:Survival Rate
chemical_list: D002945:Cisplatin; D005472:Fluorouracil