title: Amylase, lipase, pancreatic isoamylase, and phospholipase A in diagnosis of acute pancreatitis.
abstract: To determine the utility of serum amylase (AMY), lipase (Lp), pancreatic isoamylase (isoA), phospholipase A (PLA), and urine AMY in the diagnosis of acute pancreatitis, samples of serum and urine were obtained on admission and every day thereafter for 5 days from 384 patients with acute abdominal pain. Diagnostic accuracy, determined as the area under the receiver operating characteristic curve, was > 0.975 for serum AMY, Lp, isoA, and urine AMY. For each of these enzymes, a threshold value (twice to sixfold the upper limit of the reference values) offering diagnostic efficiency > 95% could be determined. In contrast, accuracy and efficiency of serum PLA were low. The profiles of these enzymes in acute pancreatitis decreased in a parallel fashion over 5 days except for PLA. We conclude that diagnostic utilities are similar for serum AMY, Lp, isoA, and urine AMY for acute pancreatitis, provided that an appropriate threshold is established.
authors.affiliation: Department of Surgery, Institut de Recerca, Hospital de la Santa Creu i Sant Pau, Barcelona, Spain.
authors.forename: P
authors.initials: P
authors.lastname: Clavé
authors.forename: S
authors.initials: S
authors.lastname: Guillaumes
authors.forename: I
authors.initials: I
authors.lastname: Blanco
authors.forename: N
authors.initials: N
authors.lastname: Nabau
authors.forename: J
authors.initials: J
authors.lastname: Mercé
authors.forename: A
authors.initials: A
authors.lastname: Farré
authors.forename: L
authors.initials: L
authors.lastname: Marruecos
authors.forename: F
authors.initials: F
authors.lastname: Lluís
mesh_terms: D000208:Acute Disease; D000681:Amylases / Q000097:blood* / Q000652:urine; D006801:Humans; D007517:Isoamylase / Q000097:blood*; D008049:Lipase / Q000097:blood*; D010195:Pancreatitis / Q000175:diagnosis* / Q000201:enzymology; D010741:Phospholipases A / Q000097:blood*
chemical_list: D008049:Lipase; D010741:Phospholipases A; D000681:Amylases; D007517:Isoamylase