title: Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly (d,l-lactic acid).
abstract: 'Large' (30-100 microns) and 'small' (10-30 microns) size range taxol-loaded microspheres composed of a blend of biodegradable poly (d,l-lactic acid) (PLA) polymer and nondegradable ethylene-vinyl acetate (EVA) copolymer were prepared using the solvent evaporation method. Encapsulation efficiencies were between 95-100% for taxol in 50:50 EVA:PLA blend microspheres. Between 10-13% of the total taxol content of the microspheres (0.6% w/v taxol loading) was released in 50 days. Using the chick chorioallantoic membrane (CAM) model, the taxol microspheres released sufficient taxol to produce vascular regression and inhibition of angiogenesis. This taxol-loaded microsphere formulation may have potential for the targeted delivery of taxol to a tumor via arterial chemoembolization.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
authors.forename: H M
authors.initials: HM
authors.lastname: Burt
authors.forename: J K
authors.initials: JK
authors.lastname: Jackson
authors.forename: S K
authors.initials: SK
authors.lastname: Bains
authors.forename: R T
authors.initials: RT
authors.lastname: Liggins
authors.forename: A M
authors.initials: AM
authors.lastname: Oktaba
authors.forename: A L
authors.initials: AL
authors.lastname: Arsenault
authors.forename: W L
authors.initials: WL
authors.lastname: Hunter
mesh_terms: D000818:Animals; D002642:Chick Embryo; D003692:Delayed-Action Preparations / Q000737:chemistry*; D066298:In Vitro Techniques; D007773:Lactates / Q000737:chemistry; D019344:Lactic Acid; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009389:Neovascularization, Pathologic; D017239:Paclitaxel / Q000008:administration & dosage*; D011108:Polymers; D011145:Polyvinyls / Q000737:chemistry
chemical_list: D003692:Delayed-Action Preparations; D007773:Lactates; D011108:Polymers; D011145:Polyvinyls; C016438:ethylenevinylacetate copolymer; D019344:Lactic Acid; D017239:Paclitaxel