Analysis of sevoflurane degradation products in vapor phase samples.
Sevoflurane degradation products were measured by GC-flame ionization detection in vapor phase samples using manual and automated injection methods. Sample handling techniques allowed the transfer and storage of samples for up to 72 h. Compound A, fluoromethyl 2,2-difluoro-1-(trifluoromethyl)vinyl ether, was the major vapor phase degradation product formed in simulated clinical conditions. Recoveries of 4-32 ppm (v/v) compound A concentrations using the manual method were in the range of 88-117% (n = 12, mean = 102%, R.S.D. = 9%).
Cunningham
D D
DD
Hospital Products Division, Abbott Laboratories, Abbott Park, IL 60064, USA.
Webster
J
J
Nelson
D
D
Williamson
B
B
D000777:Anesthetics / Q000032:analysis / Q000378:metabolism*; D001673:Biodegradation, Environmental; D002849:Chromatography, Gas; D004355:Drug Stability; D004987:Ethers / Q000032:analysis / Q000378:metabolism*; D005410:Flame Ionization; D006801:Humans; D008738:Methyl Ethers; D008954:Models, Biological; D015203:Reproducibility of Results; D000077149:Sevoflurane
D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane