title: [Silent myocardial ischemia in outpatients being treated for hyperlipoproteinemia].
abstract: BACKGROUND
  Hyperlipoproteinaemias, in particular those associated with hypercholesterolaemia, are in a causal relationship with the development and acceleration of atherogenesis. One of the serious forms of coronary heart disease is silent myocardial ischaemia--an asymptomatic objectively confirmed ischaemic episode. The objective of the present study was to 1. assess the prevalence of this disease in subjects with hyperlipoproteinaemia and 2. to assess the optimal diagnostic procedure to detect it.
  
  
  RESULTS
  The group comprises 57 subjects selected at random (23 men and 34 women) from the out-patient department for genetics and treatment of hyperlipoproteinaemias. In all subjects an ergometric loading test was made and 24-hour ambulatory ECG monitoring. Suspected silent myocardial ischaemia (i.e. positive results of the two examinations) was confirmed by load scintigraphy of the heart muscle. Silent myocardial ischaemia was proved in 3 of 23 examined men (13%) and in 4 of 34 women (11.8%).
  
  
  CONCLUSIONS
  Prevalence of silent myocardial ischaemia is significantly higher in high risk subjects--with hyperlipoproteinaemia than in the general asymptomatic population. The best screening test for its detection is a loading test and ambulatory ECG monitoring, supplemented by loading scintigraphy of the heart muscle.
authors.affiliation: II. interní klinika 1. LF UK a VFN, Praha.
authors.forename: M
authors.initials: M
authors.lastname: Tomecková
authors.forename: V
authors.initials: V
authors.lastname: Danzig
authors.forename: J
authors.initials: J
authors.lastname: Bultas
authors.forename: J
authors.initials: J
authors.lastname: Sobra
authors.forename: R
authors.initials: R
authors.lastname: Ceska
authors.forename: H
authors.initials: H
authors.lastname: Toschnerová
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006951:Hyperlipoproteinemias / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000150:complications* / Q000175:diagnosis; D012307:Risk Factors