[Efficacy and safety of loratadine vs terfenadine in the treatment of children with perennial allergic rhinitis. Capacity for inhibiting the positive cutaneous response after antihistaminic treatment].
We studied 104 medical student from the UANL with symptoms of Perennial Allergic Rhinitis, including only 30 patients for this study; seven patients with Loratadine 10 mg, eight with Loratadine 20 mg, and 15 with Terfenadine 120 mg/day/21 days, 20 mg of Loratadine and 120 mg of Terfenadine demonstrated significant decrease of the symptoms (P > 0.005). Two patients had collateral effects with Terfenadine, but Terfenadine were more effective than the Loratadine in the reduction of the skin reactivity.
Canseco Villarreal
J I
JI
Centro regional para el tratamiento y la prevención de las enfermedades alérgicas, UANL, Hospital Universitario, Monterrey, NL, México.
D000293:Adolescent; D000328:Adult; D003864:Depression, Chemical; D005260:Female; D006636:Histamine Release / Q000187:drug effects*; D006801:Humans; D007428:Intradermal Tests; D017336:Loratadine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*; D012449:Safety; D016593:Terfenadine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*
D017336:Loratadine; D016593:Terfenadine