title: Influence of hepatitis C virus (HCV) genotypes on HCV recombinant immunoblot assay patterns.
abstract: Ninety-six patients with chronic hepatitis C were studied. A second-generation recombinant immunoblot assay detected anti-NS4 antibodies significantly more often in patients infected by hepatitis C virus genotype 1 than in patients infected by other types. By a third-generation recombinant immunoblot assay, the prevalences of the four antibodies measured did not differ according to the hepatitis C virus genotype.
authors.affiliation: Department of Bacteriology and Virology, Hôpital Henri Mondor, Université Paris XII, Créteil, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Pawlotsky
authors.forename: F
authors.initials: F
authors.lastname: Roudot-Thoraval
authors.forename: C
authors.initials: C
authors.lastname: Pellet
authors.forename: P
authors.initials: P
authors.lastname: Aumont
authors.forename: F
authors.initials: F
authors.lastname: Darthuy
authors.forename: J
authors.initials: J
authors.lastname: Remire
authors.forename: J
authors.initials: J
authors.lastname: Duval
authors.forename: D
authors.initials: D
authors.lastname: Dhumeaux
mesh_terms: D000956:Antigens, Viral; D004797:Enzyme-Linked Immunosorbent Assay; D005838:Genotype; D016174:Hepacivirus / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood*; D006526:Hepatitis C / Q000276:immunology / Q000821:virology; D018937:Hepatitis C Antibodies; D018936:Hepatitis C Antigens; D006521:Hepatitis, Chronic / Q000276:immunology / Q000821:virology; D006801:Humans; D015151:Immunoblotting / Q000379:methods*; D017361:Viral Nonstructural Proteins / Q000276:immunology; D014773:Virology / Q000379:methods*
chemical_list: D000956:Antigens, Viral; D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D018936:Hepatitis C Antigens; C093542:NS4 protein, hepatitis C virus; D017361:Viral Nonstructural Proteins