Nephrotoxicity of immunosuppressive drugs.
Drugs used to modify the immune response in solid organ transplantation or autoimmune disease may cause dose-related nephrotoxicity. Cyclosporine, FK506, cyclosporine G, and rapamycin have all been studied experimentally and to a more limited extent in patients. This paper summarizes this literature using data from clinically relevant animal models.
Bennett
W M
WM
Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, Portland 97201.
Burdmann
E
E
Andoh
T
T
Elzinga
L
L
Franceschini
N
N
D058186:Acute Kidney Injury / Q000139:chemically induced*; D000818:Animals; D016572:Cyclosporine / Q000009:adverse effects; D006801:Humans; D006977:Hypertension, Renal / Q000139:chemically induced; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000139:chemically induced; D011090:Polyenes / Q000009:adverse effects; D020123:Sirolimus; D016559:Tacrolimus / Q000009:adverse effects
D007166:Immunosuppressive Agents; D011090:Polyenes; C045571:cyclosporin G; D016572:Cyclosporine; D020123:Sirolimus; D016559:Tacrolimus