[IFN in the treatment of chronic viral hepatitis. Efficacy and tolerance of lymphoblastoid alpha interferon in HIV-negative drug addicts and associated chronic active hepatitis C].
The authors evaluated the efficacy and tolerance of low dose lymphoblastoid alpha interferon in 14 i.v. drug addicts with histologically confirmed chronic active hepatitis C. Patients were treated for 12 months; all completed the whole treatment without complaining of significant side effects. Four months after withdrawal of treatment, 13 patients were found to be in clinical and biohumoral remission with serum transaminases within the normal range already after 12 weeks.
Acone
N
N
Divisione di Malattie Infettive, Ospedale Multizonale San G. Moscati di Avellino.
B1ll'Aquila
G
G
Magliocca
M
M
Nigro
F S
FS
Pacifico
P
P
Imparato
L
L
D000328:Adult; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D018023:HIV Seronegativity; D016174:Hepacivirus / Q000276:immunology; D006508:Hepatitis Antibodies / Q000032:analysis; D006526:Hepatitis C / Q000175:diagnosis / Q000628:therapy*; D018937:Hepatitis C Antibodies; D006521:Hepatitis, Chronic / Q000175:diagnosis / Q000628:therapy*; D006801:Humans; D015151:Immunoblotting; D016898:Interferon-alpha / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D007372:Interferons; D008297:Male; D015819:Substance Abuse, Intravenous / Q000150:complications*; D013997:Time Factors
D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D016898:Interferon-alpha; D007372:Interferons