Inhibition of interferon-gamma and interleukin-2 production from lymphocytes stimulated with food antigens by an anti-allergic drug, Tranilast, in patients with food-sensitive atopic dermatitis.
N(3',4'-dimethoxycinnamoyl) anthranilic acid (Tranilast) inhibits antibody-mediated hypersensitivity reactions, and is an effective drug for patients with bronchial asthma or allergic rhinitis. Interferon-gamma (IFN-gamma) production of ovalbumin (OA)-stimulated peripheral blood mononuclear cells (PBMCs) from hen's egg-sensitive patients with atopic dermatitis (AD) was significantly higher than those of healthy controls. Tranilast inhibited this IFN-gamma production. Moreover, interleukin-2 (IL-2) production of OA-stimulated PBMCs from hen's egg-sensitive patients with AD was also inhibited by Tranilast. Our results suggest that Tranilast can be used to the patients with food sensitive AD.
Kondo
N
N
Department of Pediatrics, Gifu University School of Medicine, Japan.
Fukutomi
O
O
Shinbara
M
M
Orii
T
T
D018926:Anti-Allergic Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology / Q000378:metabolism; D004311:Double-Blind Method; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D007223:Infant; D007371:Interferon-gamma / Q000096:biosynthesis*; D007376:Interleukin-2 / Q000096:biosynthesis*; D008214:Lymphocytes / Q000378:metabolism*; D010047:Ovalbumin / Q000276:immunology*; D062367:ortho-Aminobenzoates / Q000494:pharmacology*
D018926:Anti-Allergic Agents; D007376:Interleukin-2; D062367:ortho-Aminobenzoates; D007371:Interferon-gamma; D010047:Ovalbumin; C012293:tranilast