title: Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina.
abstract: The effects of photoreceptor cell degeneration on the expression of nine alpha-amino-3-hydroxy-5-methyl-isoxasole-4-propionate (AMPA)/kainate glutamate receptor subunit genes were investigated in the rd mouse retina by in situ hybridization. All known AMPA/kainate receptor subunits were found to be expressed in normal mouse retina. Following retinal degeneration, the expression of KA-1 was reduced, that of the GluR7 subunit was greatly increased, and that of the other seven subunits were not significantly affected.
authors.affiliation: Margaret M. Dyson Vision Research Institute, Department of Ophthalmology, Cornell University Medical College, New York, NY 10021, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Duvoisin
authors.forename: C
authors.initials: C
authors.lastname: Zhang
authors.forename: D E
authors.initials: DE
authors.lastname: Hamassaki-Britto
authors.forename: L R
authors.initials: LR
authors.lastname: Britto
mesh_terms: D000818:Animals; D015870:Gene Expression; D017403:In Situ Hybridization; D007608:Kainic Acid / Q000494:pharmacology; D051379:Mice; D008810:Mice, Inbred C57BL; D009410:Nerve Degeneration; D010786:Photoreceptor Cells / Q000473:pathology; D017470:Receptors, Glutamate / Q000145:classification* / Q000235:genetics; D012160:Retina / Q000473:pathology*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology
chemical_list: D017470:Receptors, Glutamate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D007608:Kainic Acid