title: Nephrotoxicity of immunosuppressive drugs.
abstract: Drugs used to modify the immune response in solid organ transplantation or autoimmune disease may cause dose-related nephrotoxicity. Cyclosporine, FK506, cyclosporine G, and rapamycin have all been studied experimentally and to a more limited extent in patients. This paper summarizes this literature using data from clinically relevant animal models.
authors.affiliation: Division of Nephrology, Hypertension and Clinical Pharmacology, Oregon Health Sciences University, Portland 97201.
authors.forename: W M
authors.initials: WM
authors.lastname: Bennett
authors.forename: E
authors.initials: E
authors.lastname: Burdmann
authors.forename: T
authors.initials: T
authors.lastname: Andoh
authors.forename: L
authors.initials: L
authors.lastname: Elzinga
authors.forename: N
authors.initials: N
authors.lastname: Franceschini
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced*; D000818:Animals; D016572:Cyclosporine / Q000009:adverse effects; D006801:Humans; D006977:Hypertension, Renal / Q000139:chemically induced; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D007676:Kidney Failure, Chronic / Q000139:chemically induced; D011090:Polyenes / Q000009:adverse effects; D020123:Sirolimus; D016559:Tacrolimus / Q000009:adverse effects
chemical_list: D007166:Immunosuppressive Agents; D011090:Polyenes; C045571:cyclosporin G; D016572:Cyclosporine; D020123:Sirolimus; D016559:Tacrolimus