[Coincidence of hepatic angiosarcoma and insulin-resistance diabetes mellitus with high-dose intraperitoneal insulin therapy].
Angiosarcoma of the liver was diagnosed at autopsy in a 50 year old female with insulin-resistant diabetes mellitus. Over the course of 27 years, the patient received 27 l of Insulin-preparations applied subcutaneously and by an intraperitoneal pump-system. The preparations contained 20 g phenol. Known carcinogens for angiosarcoma of the liver-thorotrast, monovinylchloride or arsenic-were excluded. Phenol is a well known carcinogen of the skin and its tumor-promoting potential has been demonstrated in vitro. We suggest phenol as a potential aetiologic factor for angiosarcoma of the liver.
Kersten
A
A
Pathologisches Institut der Universität Freiburg.
Schwarzkopf
J
J
Petersen
K G
KG
Lohner
M
M
D001344:Autopsy; D048909:Diabetes Complications; D003920:Diabetes Mellitus / Q000188:drug therapy* / Q000473:pathology; D005260:Female; D006394:Hemangiosarcoma / Q000150:complications / Q000473:pathology*; D006801:Humans; D007279:Injections, Subcutaneous; D007328:Insulin / Q000008:administration & dosage / Q000627:therapeutic use; D007332:Insulin Infusion Systems; D007333:Insulin Resistance; D008113:Liver Neoplasms / Q000150:complications / Q000473:pathology*; D008875:Middle Aged; D012189:Retrospective Studies
D007328:Insulin