Growth factor targeted and conventional therapy of breast cancer.
Sustained breast cancer growth and metastasis requires paracrine signals between the tumor cells and the normal surrounding host tissue. One crucial function of these signals is to recruit endothelial cells and thus new blood vessels for the nourishment of the expanding tumor mass. This proliferation and migration of endothelial cells in the vicinity of progressing tumors contrasts with the extremely low turn-over rate of endothelial cells in the healthy adult. A blockade of tumor-induced endothelial cell proliferation should inhibit tumor growth and potentially metastasis with only few adverse effects. Different therapeutic approaches that take advantage of this situation are discussed with respect to their interaction with conventional therapies of breast cancer.
Wellstein
A
A
Lombardi Cancer Center, Georgetown University, Washington, DC 20007.
D000818:Animals; D001943:Breast Neoplasms / Q000098:blood supply / Q000188:drug therapy / Q000378:metabolism / Q000628:therapy*; D002352:Carrier Proteins / Q000378:metabolism; D017321:Clinical Trials, Phase I as Topic; D003510:Cyclohexanes; D016207:Cytokines / Q000378:metabolism; D004730:Endothelium, Vascular / Q000187:drug effects / Q000503:physiopathology; D004815:Epidermal Growth Factor / Q000037:antagonists & inhibitors / Q000096:biosynthesis / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic; D006131:Growth Inhibitors / Q000627:therapeutic use*; D006133:Growth Substances / Q000502:physiology*; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008325:Mammary Neoplasms, Experimental / Q000098:blood supply / Q000188:drug therapy / Q000378:metabolism / Q000503:physiopathology; D009363:Neoplasm Proteins / Q000096:biosynthesis / Q000235:genetics / Q000378:metabolism; D009389:Neovascularization, Pathologic / Q000188:drug therapy*; D000077609:O-(Chloroacetylcarbamoyl)fumagillol; D010426:Pentosan Sulfuric Polyester / Q000627:therapeutic use; D051381:Rats; D012717:Sesquiterpenes / Q000627:therapeutic use
D002352:Carrier Proteins; D003510:Cyclohexanes; D016207:Cytokines; D006131:Growth Inhibitors; D006133:Growth Substances; C587883:HBEGF protein, human; C587885:Hbegf protein, rat; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins; D012717:Sesquiterpenes; C066845:pleiotrophin; D010426:Pentosan Sulfuric Polyester; D004815:Epidermal Growth Factor; D000077609:O-(Chloroacetylcarbamoyl)fumagillol