title: Cytotoxic biflavonoids from Selaginella willdenowii.
abstract: Bioactivity-guided fractionation of the leaves of Selaginella willdenowii afforded three known biflavones, 4',7"-di-O-methylamentoflavone, isocryptomerin and 7"-O-methylrobustaflavone, that were significantly cytotoxic against a panel of human cancer cell lines. Non-cytotoxic isolates were also obtained, namely, amentoflavone, bilobetin, robustaflavone and 2",3"-dihydroisocryptomerin, a new dihydrobiflavone. The structure for the new biflavonoid was unambiguously assigned by a combination of spectroscopic methods.
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA.
authors.forename: G L
authors.initials: GL
authors.lastname: Silva
authors.forename: H
authors.initials: H
authors.lastname: Chai
authors.forename: M P
authors.initials: MP
authors.lastname: Gupta
authors.forename: N R
authors.initials: NR
authors.lastname: Farnsworth
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: C W
authors.initials: CW
authors.lastname: Beecher
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000633:toxicity; D002460:Cell Line; D005419:Flavonoids / Q000302:isolation & purification* / Q000633:toxicity*; D006801:Humans; D008175:Lung Neoplasms; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009904:Optical Rotation; D018515:Plant Leaves; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D005419:Flavonoids