Hyponatremia and osmoregulation of vasopressin secretion in patients with intracranial bleeding.
To clarify the cause and pathophysiology of hyponatremia after intracranial bleeding, we analyzed the possible causative factors, and examined the response of vasopressin (AVP) secretion to osmotic stimulus in six patients. Despite hyponatremia, urinary sodium excretion persisted, with urinary osmolality exceeding plasma osmolality. Serum levels of urea nitrogen, creatinine, and uric acid were not elevated in any of them. PRA was normal or subnormal in four patients, and all had normal adrenocortical and thyroid functions. Although these laboratory findings may support the diagnosis of the syndrome of inappropriate antidiuretic hormone secretion, the cause of hyponatremia in our patients was attributed to excessive renal excretion of sodium, because water load performed in an euvolemic state showed no impairment in diuresis, and replenishment of sodium without water restriction improved hyponatremia as well as clinical conditions. Plasma AVP levels relative to plasma osmolality in these patients were constantly elevated. When challenged by an osmotic stimulus, AVP secretion increased with increasing plasma osmolality in one patient, but no consistent pattern of AVP secretion was observed in others. The potentiating effect of hypovolemia on osmotic secretion of AVP was not demonstrated in any of the patients. These results show that hyponatremia after intracranial bleeding with clinical features almost indistinguishable from those of syndrome of inappropriate antidiuretic hormone secretion may result from an impaired renal sodium-conserving mechanism of unknown cause. Persistent AVP secretion without an alteration in the sensitivity of the osmostat in this pathological state may be due to an incomplete suppression by plasma hypotonicity per se of the baroreceptor-mediated stimulation of AVP release.
Kamoi
K
K
Department of Medicine, Nagaoka Red Cross Hospital, Niigata, Japan.
Toyama
M
M
Ishibashi
M
M
Yamaji
T
T
D000368:Aged; D000369:Aged, 80 and over; D001127:Arginine Vasopressin / Q000097:blood / Q000378:metabolism*; D001794:Blood Pressure; D001806:Blood Urea Nitrogen; D002543:Cerebral Hemorrhage / Q000097:blood / Q000503:physiopathology* / Q000652:urine; D006339:Heart Rate; D006801:Humans; D007010:Hyponatremia / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000097:blood; D011863:Radioimmunoassay; D012083:Renin / Q000097:blood; D012964:Sodium / Q000097:blood* / Q000652:urine; D013997:Time Factors; D014527:Uric Acid / Q000097:blood; D014882:Water-Electrolyte Balance
D001127:Arginine Vasopressin; D014527:Uric Acid; D012964:Sodium; D012083:Renin; D011188:Potassium