Evidence that molecules on the surface of one cell can adhere to the oligosaccharide portion of gangliosides on the surface of another cell.
While there have been numerous reports concerning the possible role(s) of gangliosides in neuronal development and their efficacy, or lack thereof, as possible therapeutic agents for the treatment of neuronal injury, the molecular mechanisms by which they induce specific cellular effects are not well understood. This review presents evidence for the existence of cell surface molecules able to adhere to the oligosaccharide portion of specific gangliosides and describes methods employed for their study. The identification of such cell surface molecules permits the hypothesis that the binding of the oligosaccharide portion of the ganglioside by its cell surface receptor is responsible for initiating the intracellular reactions that lead to modified cell behavior.
Schengrund
C L
CL
Department of Biochemistry and Molecular Biology, Milton S. Hershey Medical Center, Pennsylvania State University, Hershey 17033, USA.
D002240:Carbohydrate Sequence; D002352:Carrier Proteins; D002448:Cell Adhesion; D002450:Cell Communication; D005732:Gangliosides / Q000378:metabolism*; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009844:Oligosaccharides / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000502:physiology*
D002352:Carrier Proteins; D005732:Gangliosides; D009844:Oligosaccharides; D011956:Receptors, Cell Surface