title: Leukocyte hexokinase activity in aging and Alzheimer disease.
abstract: We determined the effects of clinical variables on hexokinase (HK) activity in leukocytes from Alzheimer's disease (AD) patients and controls. Age accounted for 51% of the variance in HK activity in the young and 23% in the old. Duration of illness in both familial and sporadic AD accounted for HK levels by 32 and 38%, respectively. Hexokinase activity increases with age and does not discriminate between familial and sporadic AD.
authors.affiliation: Department of Neurology, Medical College of Wisconsin, Milwaukee 53226, USA.
authors.forename: P G
authors.initials: PG
authors.lastname: Antuono
authors.forename: J
authors.initials: J
authors.lastname: Ravanelli-Meyer
authors.forename: K
authors.initials: K
authors.lastname: Nicholson
authors.forename: A S
authors.initials: AS
authors.lastname: Bloom
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000201:enzymology*; D004734:Energy Metabolism; D005190:Family; D006593:Hexokinase / Q000378:metabolism*; D006801:Humans; D007962:Leukocytes / Q000201:enzymology*; D008875:Middle Aged
chemical_list: D006593:Hexokinase