IgE antibodies reactive with silverfish, cockroach and chironomid are frequently found in mite-positive allergic patients.
Approximately 30% of the house dust mite allergic patients in The Netherlands have IgE antibodies reactive with silverfish, cockroach and/or chironomid. In allergic patients without IgE antibodies against Dermatophagoides pteronyssinus less than 5% have IgE antibodies reactive with these insects. By means of RAST inhibition studies it is shown that cross-reactivity exists between D. pteronyssinus and silverfish, cockroach or chironomid. This means that a positive RAST for silverfish, cockroach, chironomid or D. pteronyssinus cannot be taken as evidence for exposure.
Witteman
A M
AM
Central Laboratory of The Netherlands Red Cross Blood Transfusion Service, University of Amsterdam.
van den Oudenrijn
S
S
van Leeuwen
J
J
Akkerdaas
J
J
van der Zee
J S
JS
Aalberse
R C
RC
D000818:Animals; D001249:Asthma / Q000276:immunology*; D002683:Chironomidae / Q000276:immunology*; D003058:Cockroaches / Q000276:immunology*; D003429:Cross Reactions; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology*; D007073:Immunoglobulin E / Q000276:immunology*; D007313:Insecta / Q000276:immunology*; D008925:Mites / Q000276:immunology*; D011852:Radioallergosorbent Test; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology*
D007073:Immunoglobulin E