Electrophysiology of the inner mitochondrial membrane.
The application of electrophysiological techniques to mitochondrial membranes has allowed the observation and partial characterization of several ion channels, including an ATP-sensitive K(+)-selective one, a high-conductance "megachannel", a 107 pS anionic channel and three others studied at alkaline pH's. A reliable correlation with the results of non-electrophysiological studies has been obtained so far only for the first two cases. Activities presumed to be associated with the Ca2+ uniporter and with the adenine nucleotide translocator, as well as the presence of various other conductances have also been reported. The review summarizes the main properties of these pores and their possible relationship to permeation pathways identified in biochemical studies.
Zoratti
M
M
Department of Biomedical Sciences, University of Padova, Italy.
Szabó
I
I
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D004594:Electrophysiology / Q000379:methods; D007425:Intracellular Membranes / Q000502:physiology*; D007473:Ion Channels / Q000502:physiology*; D008928:Mitochondria / Q000502:physiology*; D000226:Mitochondrial ADP, ATP Translocases / Q000378:metabolism; D015221:Potassium Channels / Q000502:physiology
D002352:Carrier Proteins; D007473:Ion Channels; D015221:Potassium Channels; D000255:Adenosine Triphosphate; D000226:Mitochondrial ADP, ATP Translocases; D002118:Calcium