Leukocyte trafficking mediated by selectin-carbohydrate interactions.
The selectins have attracted intense interest because of their carbohydrate-recognition properties and their pivotal roles in leukocyte trafficking. Future studies will center on the mechanisms for regulating the expression of the selectins and their ligands, the molecular details of selectin binding to glycoprotein ligands and small carbohydrates, and the biophysical principles that selectins employ to mediate attachment and rolling of leukocytes under flow.
McEver
R P
RP
Department of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City 73104, USA.
Moore
K L
KL
Cummings
R D
RD
D000818:Animals; D002240:Carbohydrate Sequence; D002241:Carbohydrates / Q000097:blood*; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000502:physiology*; D019040:E-Selectin; D004730:Endothelium, Vascular / Q000502:physiology; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D019041:L-Selectin; D007962:Leukocytes / Q000502:physiology*; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000502:physiology; D015398:Signal Transduction
D002241:Carbohydrates; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D006023:Glycoproteins; D019041:L-Selectin