title: Identification of murine loci associated with susceptibility to chronic experimental autoimmune encephalomyelitis.
abstract: B10.RIII mice develop chronic and relapsing experimental autoimmune encephalomyelitis (EAE) after immunization with the myelin basic protein (MBP) peptide 89-101. The disease is associated with the major histocompatibility complex (MHC) (eae1). We have now investigated the importance of non-MHC regions for the EAE susceptibility in a cross between RIIIS/J and B10.RIII mice which share the MHC region but differ in disease susceptibility. Linkage analysis using microsatellite markers spanning the genome identified a region (eae2) on chromosome 15 which showed linkage to disease (P = 0.0002). Our data also suggest linkage to a second region (eae3) on chromosome 3 (P = 0.0024), and provide evidence for locus interactions between eae2 and eae3. These results provide clues to the genetic basis of multiple sclerosis.
authors.affiliation: Department of Medical Genetics, Uppsala University, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Sundvall
authors.forename: J
authors.initials: J
authors.lastname: Jirholt
authors.forename: H T
authors.initials: HT
authors.lastname: Yang
authors.forename: L
authors.initials: L
authors.lastname: Jansson
authors.forename: A
authors.initials: A
authors.lastname: Engström
authors.forename: U
authors.initials: U
authors.lastname: Pettersson
authors.forename: R
authors.initials: R
authors.lastname: Holmdahl
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004276:DNA, Satellite / Q000235:genetics; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000209:etiology / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D007114:Immunization; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000235:genetics / Q000276:immunology; D010446:Peptide Fragments / Q000235:genetics / Q000276:immunology; D010641:Phenotype; D013045:Species Specificity
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers; D004676:Myelin Basic Protein; D010446:Peptide Fragments