The expression of self antigenic determinants: implications for tolerance and autoimmunity.
T lymphocytes respond to small peptides in the context of major histocompatibility molecules and a host of other cell-surface proteins on antigen-presenting cells. By design, therefore, T-cell responses are dependent on the efficient and accurate processing of both foreign and self peptides by antigen-presenting cells. This review examines the functions of T cells that may be specific for self peptides processed and presented under less than ideal conditions or outside the normal pathways of antigen processing. Do these T cells survive selection events and remain in the repertoire of normal lymphocytes? Moreover, can these cells become activated and are they important in the pathogenesis of autoimmunity?
Mamula
M J
MJ
Yale University School of Medicine, New Haven.
Craft
J
J
D000818:Animals; D017951:Antigen Presentation; D000938:Antigen-Presenting Cells; D001324:Autoantigens / Q000096:biosynthesis* / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology*; D000939:Epitopes / Q000096:biosynthesis* / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology
D001324:Autoantigens; D000939:Epitopes