title: Synthesis and characterization of hydroxylated polychlorinated biphenyls (PCBs) identified in human serum.
abstract: Hydroxylated polychlorinated biphenyls (PCBs) have been identified in wildlife and human samples. Most of these compounds are highly chlorinated (penta-hepatachloro) and contain a single meta- or para-hydroxyl group. Using the Cadogan coupling procedure, the following hydroxy-PCBs congeners were synthesized: 2,3,3',4',5-pentachloro-4-biphenylol, 2,3',4,4',5-pentachloro-3-biphenylol, 2',3,3',4',5-pentachloro-4-biphenylol, 2,2',3',4,4'-pentachloro-3-biphenylol, 2,2',3,3',4',5-pentachloro-4-biphenylol, 2,2',3',4,4',5-hexachloro-3-biphenylol, 2,2',3,4',5,5'-hexachloro-4-biphenylol, 2,2',3,3',4',5,5'-heptachloro-4-biphenylol, 2,2',3',4,4',5,5'-hepatachloro-3-biphenylol, 2,2',3,4',5,5',6-heptachloro-4-biphenylol. Many of these compounds have been detected as residues in human serum and current studies are investigating their activities as agonists and antagonists for several endocrine-mediated responses.
authors.affiliation: Department of Veterinary Physiology & Pharmacology, Texas A&M University, College Station 77843-4466, USA.
authors.forename: S
authors.initials: S
authors.lastname: Safe
authors.forename: K
authors.initials: K
authors.lastname: Washburn
authors.forename: T
authors.initials: T
authors.lastname: Zacharewski
authors.forename: T
authors.initials: T
authors.lastname: Phillips
mesh_terms: D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011078:Polychlorinated Biphenyls / Q000097:blood* / Q000138:chemical synthesis* / Q000737:chemistry
chemical_list: D011078:Polychlorinated Biphenyls