[Studies on electrophysiology of lysophosphatidylcholine and evaluation of its clinical significance].
The cellular electrophysiological effects of lysosphatidylcholine (LPC) were investigated by using patch-clamp whole cell recording and conventional microelectrode technique, LPC(10 microns) suppressed the sodium, background potassium and calcium current and the effect of LPC on activity of ionic channels was nonselective. Resting potential, action potential amplitude and maximal rate of rise of phase of action potential were decreased with LPC (50 microns) perfusing. The incidence of abnormal automaticity, early after depolarization (EAD) and delayed after depolarization (DAD) was higher. It is clearly shown that LPC accumulates at early time of myocardial ischemia and thus may induce ischemic arrhythmias.
Xu
H D
HD
Department of Cardiovascular Diseases, First Affiliated Hospital, Suzhou Medical College.
Qiu
C G
CG
Jiang
W P
WP
D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001145:Arrhythmias, Cardiac / Q000209:etiology; D004594:Electrophysiology; D006168:Guinea Pigs; D007473:Ion Channels / Q000187:drug effects*; D008244:Lysophosphatidylcholines / Q000494:pharmacology*; D017202:Myocardial Ischemia / Q000503:physiopathology*; D010210:Papillary Muscles / Q000166:cytology
D007473:Ion Channels; D008244:Lysophosphatidylcholines