[The participation of the glutaminergic input of the nucleus accumbens in regulating the synaptic release of dopamine during associative learning].
The effect of MK-801 on basal and conditioned dopamine release in the rat n. accumbens, was studied. Exposure of the rats to the box where they had been given electrical shock, caused an immediate long lasting increase in the dopamine release. Administration of the MK-801 into the n. accumbens abolished the delayed increase in the dopamine release while exerting no effect on the immediate increase.
Saul'skaia
N B
NB
Marsden
C A
CA
D000818:Animals; D001245:Association Learning / Q000187:drug effects / Q000502:physiology*; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D004298:Dopamine / Q000378:metabolism*; D004558:Electric Stimulation; D004644:Emotions / Q000187:drug effects / Q000502:physiology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D008297:Male; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D017470:Receptors, Glutamate / Q000187:drug effects / Q000502:physiology*; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors; D013569:Synapses / Q000187:drug effects / Q000378:metabolism*
D018691:Excitatory Amino Acid Antagonists; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate; D004298:Dopamine