title: Leukemoid reaction resulting from multiple cytokine production in metastatic mucoepidermoid carcinoma with central necrosis.
abstract: We report a male patient with metastatic high-grade mucoepidermoid carcinoma and associated leukemoid reaction. The patient was transferred to our hospital due to persistent spiking fever, marked granulocytosis, and suspected liver abscess. After thorough bacteriological studies, including cultures of blood and material aspirated from the "liver abscess", no evidence of infection was documented. The patient suffered from persistent spiking fever for more than 4 weeks in spite of empirical antibiotic treatment, and repeated aspiration of the presupposed liver abscess. He underwent exploratory laparotomy for intended surgical evacuation of the liver abscess and bacteriological diagnosis. The operative findings were compatible with metastatic carcinoma with multiple liver and retroperitoneal lymph node involvement and tumor necrosis. The pathology report indicated high-grade mucoepidermoid carcinoma. Immunohistochemistry showed positive staining for interleukin-1 alpha (IL-1 alpha) and IL-6. Elevation of cytokine levels in the necrotic tumor fluid, including IL-1 alpha, IL-6, granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor was confirmed by ELISA test. This case shows that multiple cytokine production from a metastatic tumor and its central necrotic area in the liver can produce a febrile leukemoid reaction mimicking a pyogenic liver abscess.
authors.affiliation: Cancer Clinical Research Center, Institute of Biomedical Sciences, Academia Sinica, Taipei.
authors.forename: Y M
authors.initials: YM
authors.lastname: Chen
authors.forename: J
authors.initials: J
authors.lastname: Whang-Peng
authors.forename: J M
authors.initials: JM
authors.lastname: Liu
authors.forename: Y
authors.initials: Y
authors.lastname: Chao
authors.forename: C R
authors.initials: CR
authors.lastname: Lai
authors.forename: S Y
authors.initials: SY
authors.lastname: Wang
authors.forename: R P
authors.initials: RP
authors.lastname: Perng
mesh_terms: D000008:Abdominal Neoplasms / Q000556:secondary; D018277:Carcinoma, Mucoepidermoid / Q000276:immunology* / Q000556:secondary*; D016207:Cytokines / Q000096:biosynthesis*; D003937:Diagnosis, Differential; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D007955:Leukemoid Reaction; D008099:Liver / Q000473:pathology*; D008100:Liver Abscess / Q000276:immunology; D008113:Liver Neoplasms / Q000276:immunology* / Q000473:pathology; D008175:Lung Neoplasms / Q000556:secondary; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D009382:Neoplasms, Unknown Primary; D012468:Salivary Gland Neoplasms / Q000556:secondary
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor