title: Physiologic state severity classification as an indicator of posttrauma cytokine response.
abstract: A Physiologic State Severity Classification (PSSC) derived from clustering of 17 cardiorespiratory variables was used to predict cytokine response in critically ill posttrauma patients. The PSSC defined physiologic states: A-State (A), normal stress response; B-State (B), metabolic insufficiency; C2-State (C), respiratory insufficiency. Bayesian analysis of these states defined a probability of death (Pdeath). 416 studies from 60 newly studied multiple trauma patients (70% males, Injury Severity Score = 27.5) were analyzed; 45 (75%) had sepsis (s), 28 (47%) had sepsis-adult respiratory distress syndrome (s-ARDS). Of 35 survivors (66% s, 37% s-ARDS, mean Pdeath = .42) 23% were predominantly A, 66% B, and 11% C. Of 25 deaths (88% s, 60% s-ARDS, mean Pdeath = .64) 0% were A, 44% B, and 56% C. PSSC States were correlated with incidence and mean plasma levels (pl) in picograms/mL of cytokines. 23 samples from recovering nonseptic trauma patients were used as controls.
authors.affiliation: Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark 07103, USA.
authors.forename: D
authors.initials: D
authors.lastname: Rixen
authors.forename: J H
authors.initials: JH
authors.lastname: Siegel
authors.forename: A
authors.initials: A
authors.lastname: Abu-Salih
authors.forename: M
authors.initials: M
authors.lastname: Bertolini
authors.forename: F
authors.initials: F
authors.lastname: Panagakos
authors.forename: N
authors.initials: N
authors.lastname: Espina
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016207:Cytokines / Q000097:blood*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D008297:Male; D008875:Middle Aged; D009104:Multiple Trauma / Q000097:blood* / Q000145:classification / Q000401:mortality / Q000628:therapy; D012189:Retrospective Studies; D015996:Survival Rate; D015599:Trauma Severity Indices
chemical_list: D016207:Cytokines