Comparison of rufloxacin and norfloxacin effects on faecal flora.
The suppression of faecal Escherichia coli by quinolones was studied in a randomized cross-over phase I trial with single oral doses of 400 mg rufloxacin or norfloxacin. Both drugs caused > 70% decontamination in a similar number of subjects in the 72 h post-dose period (83% vs 100% respectively), but suppression of E. coli at 168 h was significantly (P < 0.05) higher after rufloxacin (83.3 vs 40%).
Marco
F
F
Microbiology Department, Hospital Clinic i Provincial, Barcelona, Spain.
Giménez
M J
MJ
Jiménez de Anta
M T
MT
Marcos
M A
MA
Salvá
P
P
Aguilar
L
L
D000328:Adult; D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000187:drug effects; D005243:Feces / Q000737:chemistry / Q000382:microbiology*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D009643:Norfloxacin / Q000493:pharmacokinetics / Q000494:pharmacology*; D015363:Quinolones / Q000493:pharmacokinetics / Q000494:pharmacology*
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D009643:Norfloxacin; C060328:rufloxacin