Pharmacokinetics and hepatic first-pass effect of (-)-carbovir in the anesthetized rat.
Studies were designed to allow an in vivo estimation of the hepatic extraction ratio and to test the hypothesis that the pharmacokinetic parameters of (-)-CBV are significantly different during anesthesia. (-)-CBV was administered as an i.v. bolus followed by i.v. infusion into either the portal (n = 3) or the jugular (n = 3) veins of anesthetized male Sprague-Dawley rats. These studies indicate that (-)-CBV had a very low hepatic extraction ratio, in agreement with previous (-)-CBV in situ liver perfusion studies. Additionally, anesthesia was shown to alter the pharmacokinetics of (-)-CBV by reducing the total body clearance of this drug.
Soria
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Department of Pharmaceutics, University of Minnesota, Minneapolis 55455, USA.
Zimmerman
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D000758:Anesthesia; D000818:Animals; D000998:Antiviral Agents / Q000493:pharmacokinetics*; D015224:Dideoxynucleosides / Q000493:pharmacokinetics*; D007275:Injections, Intravenous; D008099:Liver / Q000378:metabolism*; D008297:Male; D010599:Pharmacokinetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D000998:Antiviral Agents; D015224:Dideoxynucleosides; C057503:carbovir