Adhesion molecule expression on peripheral blood mononuclear cells in rheumatoid arthritis: positive correlation between the proportion of L-selectin and disease activity.
The expression of a series of adhesion molecules (the integrin family, the immunoglobulin superfamily, CD44 and the selectin family) on peripheral blood mononuclear cells (PBMC) from RA patients was investigated by flow-cytometry. L-Selectin (CD62L) in the selectin family was more significantly expressed on PBMC from RA patients as compared to those from normal controls. Further, RA patients exhibited a slight but significant increase of VLA-alpha 2 (CDw49b), p150,95 (CD11c), and VNR-beta (CD61) in the integrin family. The enhanced expression of L-selectin was positively correlated with disease activity. An increase in the proportion of L-selectin+CD4+ cells in PBMC from patients with RA and its clinical significance is reported.
Kurohori
Y
Y
Institute of Rheumatology, Tokyo Women's Medical College, Japan.
Sato
K
K
Suzuki
S
S
Kashiwazaki
S
S
D001172:Arthritis, Rheumatoid / Q000097:blood / Q000378:metabolism* / Q000503:physiopathology; D001773:Blood Cells / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000378:metabolism*; D006801:Humans; D018960:Hyaluronan Receptors; D007136:Immunoglobulins / Q000378:metabolism; D016023:Integrins / Q000378:metabolism; D019041:L-Selectin; D009000:Monocytes / Q000378:metabolism*; D011956:Receptors, Cell Surface / Q000378:metabolism; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism
D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D018960:Hyaluronan Receptors; D007136:Immunoglobulins; D016023:Integrins; D011956:Receptors, Cell Surface; D016201:Receptors, Lymphocyte Homing; D019041:L-Selectin