C-terminal amino groups facilitate membrane incorporation of gramicidin derivatives.
Gramicidin derivatives with (positively-charged) C-terminal amino groups are found to incorporate readily and refold quickly when added to dioleoylphosphatidylcholine lipid vesicles from concentrated methanol solutions. Neutral and negatively-charged derivatives do not.
Jaikaran
D C
DC
Department of Chemistry, University of Toronto, Canada.
Zhang
Z
Z
Woolley
G A
GA
D002942:Circular Dichroism; D006096:Gramicidin / Q000737:chemistry*; D010713:Phosphatidylcholines / Q000737:chemistry; D017510:Protein Folding; D013329:Structure-Activity Relationship
D010713:Phosphatidylcholines; D006096:Gramicidin; C017251:1,2-oleoylphosphatidylcholine