title: Plasma levels of von Willebrand factor in non-insulin-dependent diabetes mellitus are influenced by dietary monounsaturated fatty acids.
abstract: We have previously demonstrated a lowering effect on von Willebrand Factor (vWF) of a diet rich in monounsaturated fatty acids (MUFA) as compared with a high-carbohydrate diet. In the present study 16 non-insulin dependent diabetic (NIDDM) subjects participated in a cross-over experiment on an out-patient basis comparing the effects on vWF of three weeks treatments with two diets similar in carbohydrate and protein content, one rich in MUFA (30 energy %) and one rich in polyunsaturated fatty acids (PUFA) (30 energy %). Before and on the last day of the two diets, the levels of vWF, fibrinogen, fibronectin and alpha 2-macroglobulin were measured. After 3 weeks diet intervention vWF levels were lower after the MUFA regimen compared with the PUFA diet (mean +/- SD) (1.15 +/- 0.36 vs 1.32 +/- 0.42 U/ml, p = 0.003). Similar and unchanged levels of fibrinogen, fibronectin and alpha 2-macroglobulin were seen. In conclusion, three weeks on a diet rich in MUFA lowers vWF as compared with a PUFA rich diet, suggesting a beneficial effect of MUFA on the endothelium in NIDDM patients.
authors.affiliation: Department of Endocrinology and Metabolism, Aarhus Amtssygehus, Denmark.
authors.forename: C
authors.initials: C
authors.lastname: Thomsen
authors.forename: O W
authors.initials: OW
authors.lastname: Rasmussen
authors.forename: J
authors.initials: J
authors.lastname: Ingerslev
authors.forename: K
authors.initials: K
authors.lastname: Hermansen
mesh_terms: D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000178:diet therapy*; D003927:Diet, Diabetic; D004041:Dietary Fats / Q000627:therapeutic use; D004042:Dietary Fats, Unsaturated / Q000627:therapeutic use; D005229:Fatty Acids, Monounsaturated / Q000627:therapeutic use*; D005231:Fatty Acids, Unsaturated / Q000627:therapeutic use; D005260:Female; D005340:Fibrinogen / Q000032:analysis; D005353:Fibronectins / Q000097:blood; D006801:Humans; D008297:Male; D008875:Middle Aged; D000069463:Olive Oil; D010938:Plant Oils / Q000627:therapeutic use; D000511:alpha-Macroglobulins / Q000032:analysis; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D004041:Dietary Fats; D004042:Dietary Fats, Unsaturated; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D005353:Fibronectins; D000069463:Olive Oil; D010938:Plant Oils; D000511:alpha-Macroglobulins; D014841:von Willebrand Factor; D005340:Fibrinogen