Autoimmune mechanisms in the pathogenesis of paraneoplastic nervous system disease.
There is compelling circumstantial evidence that humoral autoimmune response may be involved in the generation of paraneoplastic neurologic syndromes (PNS). However, still it is unproven whether the autoantibody is pathogenic or represents an epiphenomenon to the actual disease process. Paraneoplastic antibodies have been identified in patients with PNS which react with similar antigenic epitopes in tumor and neurons. However, the antigens identified by the paraneoplastic antibodies are primarily intracellular in location, questioning the pathogenetic role of the antibody. The molecular events of antigen processing and presentation, T-cell receptor restriction, polyclonal B-cell proliferation, cellular immunity, and the role of cytokines in mediation of neuronal injury must be further defined in order to elucidate the role of autoimmunity in the pathogenesis of these disorders.
Jaeckle
K A
KA
Department of Neuro-Oncology, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
D000951:Antigens, Neoplasm / Q000276:immunology; D001324:Autoantigens; D001327:Autoimmune Diseases / Q000276:immunology*; D016207:Cytokines / Q000502:physiology; D004268:DNA-Binding Proteins / Q000276:immunology; D051959:ELAV Proteins; D000939:Epitopes / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007111:Immunity, Cellular / Q000276:immunology; D009363:Neoplasm Proteins / Q000276:immunology; D009419:Nerve Tissue Proteins; D009422:Nervous System Diseases / Q000276:immunology*; D009474:Neurons / Q000276:immunology; D010257:Paraneoplastic Syndromes / Q000276:immunology*; D016601:RNA-Binding Proteins / Q000276:immunology
D000951:Antigens, Neoplasm; D001324:Autoantigens; C063762:CDR1 protein, human; C095184:CDR2 protein, human; D016207:Cytokines; D004268:DNA-Binding Proteins; D051959:ELAV Proteins; D000939:Epitopes; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins