Human growth hormone but not human insulin-like growth factor-I enhances recovery from neonatal malnutrition in rats.
The ability of hormonal therapy to enhance recovery from neonatal malnutrition was assessed in rats. Pups were malnourished via maternal food restriction (60% control intake). On d 16, restricted pups (n = 50) (62% control body wt) were refed until d 20 and were given growth hormone, insulin-like growth factor-I, destripeptide [1,3] insulin-like growth factor-I, or saline (placebo). Refed-placebo pups attained 80% of control body weight by d 20. Growth hormone treatment caused a greater weight gain than refeeding alone (P < or = 0.05). Treatment with insulin-like growth factor-I and destripeptide [1,3] insulin-like growth factor-I did not affect body weight. All three hormones increased spleen and kidney weights (P < or = 0.05) compared with the refed-placebo group, whereas only growth hormone increased muscle weight (P < or = 0.05). Malnourished pups had lower serum insulin-like growth factor-I (P < or = 0.05) and insulin-like growth factor binding protein-3 (P < or = 0.05), and higher serum insulin-like growth factor binding protein-2 (P < or = 0.05) and hepatic insulin-like growth factor binding protein-2 mRNA (P < or = 0.05) than controls. Refeeding increased serum insulin-like growth factor-I compared with restricted pups (P < or = 0.05), and insulin-like growth factor-I treatment caused a further increase in serum insulin-like growth factor-I compared with the refed-placebo group (P < or = 0.05). These results show that growth hormone was moderately effective at increasing body weight gain and muscle growth during recovery from malnutrition.
Zhao
X
X
Division of Foods and Nutrition, University of Illinois, Urbana 61801, USA.
Unterman
T G
TG
Donovan
S M
SM
D000818:Animals; D000831:Animals, Newborn; D001823:Body Composition / Q000187:drug effects / Q000502:physiology; D002352:Carrier Proteins / Q000032:analysis / Q000097:blood / Q000235:genetics; D004195:Disease Models, Animal; D005260:Female; D013006:Growth Hormone / Q000494:pharmacology / Q000627:therapeutic use*; D018969:Insulin-Like Growth Factor Binding Proteins; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000494:pharmacology / Q000627:therapeutic use*; D007668:Kidney / Q000737:chemistry / Q000254:growth & development; D008099:Liver / Q000737:chemistry / Q000254:growth & development; D009748:Nutrition Disorders / Q000188:drug therapy* / Q000503:physiopathology; D009929:Organ Size; D010446:Peptide Fragments / Q000494:pharmacology / Q000627:therapeutic use; D011247:Pregnancy; D012333:RNA, Messenger / Q000032:analysis / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013154:Spleen / Q000737:chemistry / Q000254:growth & development; D015430:Weight Gain / Q000187:drug effects
D002352:Carrier Proteins; D018969:Insulin-Like Growth Factor Binding Proteins; D010446:Peptide Fragments; D012333:RNA, Messenger; C058957:insulin-like growth factor 1, des-(1-3)-; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone