title: Dibutyryl cyclic adenosine monophosphate stimulates the sodium pump in rabbit renal cortical tubules.
abstract: The elevation in oxygen consumption (QO2) observed following addition of the sodium ionophore nystatin in suspensions of rabbit renal proximal tubules was significantly increased by 1 mM dibutyryl cyclic adenosine monophosphate (db-cAMP). The QO2 after subsequent addition of strophanthidin to block the sodium pump was unaffected by db-cAMP. However, 10 microM forskolin in the presence of 100 microM IBMX had no significant effect on the QO2 observed following addition of either nystatin or strophanthidin. Nevertheless, we can conclude that db-cAMP does stimulate the sodium pump activity independently of sodium transport mechanisms in the rabbit renal proximal tubule.
authors.affiliation: Groupe de Recherche en Transport Membranaire, Université de Montréal, Qué., Canada.
authors.forename: J S
authors.initials: JS
authors.lastname: Beck
authors.forename: M
authors.initials: M
authors.lastname: Marsolais
authors.forename: J
authors.initials: J
authors.lastname: Nöel
authors.forename: S
authors.initials: S
authors.lastname: Breton
authors.forename: R
authors.initials: R
authors.lastname: Laprade
mesh_terms: D015056:1-Methyl-3-isobutylxanthine / Q000494:pharmacology; D000818:Animals; D003994:Bucladesine / Q000378:metabolism / Q000494:pharmacology*; D002469:Cell Separation; D003078:Colchicine / Q000494:pharmacology; D005576:Colforsin / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000378:metabolism; D009761:Nystatin / Q000494:pharmacology; D010101:Oxygen Consumption / Q000187:drug effects; D011817:Rabbits; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000378:metabolism*; D013327:Strophanthidin / Q000494:pharmacology
chemical_list: D009761:Nystatin; D005576:Colforsin; D003994:Bucladesine; D013327:Strophanthidin; D000242:Cyclic AMP; D000254:Sodium-Potassium-Exchanging ATPase; D003078:Colchicine; D015056:1-Methyl-3-isobutylxanthine