title: Iron uptake by plasma cells in haematological disorders.
abstract: Bone marrows of 38 patients have been investigated for iron-containing plasma cells. Two patterns emerged. One consisting of iron-laden plasma cells involving myeloma, iron overload and megaloblastic anaemia patients. The second showing no iron in plasma cells of patients with anaemia of chronic disease (ACD). Electron microscopy was done on 3 patients who had excess iron in their bone marrow particles and plasma cells. Perls' stain and scanning transmission electron microscopy were used to confirm the presence of iron in bone marrow plasma cells. The results show that the uptake of iron by plasma cells is dependent on marrow iron stores and the availability of the iron for uptake.
authors.affiliation: Department of Haematology, University of Pretoria, South Africa.
authors.forename: R A
authors.initials: RA
authors.lastname: Mattana
authors.forename: L
authors.initials: L
authors.lastname: Du Plessis
authors.forename: K
authors.initials: K
authors.lastname: Stevens
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001853:Bone Marrow / Q000378:metabolism / Q000648:ultrastructure; D002648:Child; D005260:Female; D006402:Hematologic Diseases / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008297:Male; D017348:Microscopy, Electron, Scanning Transmission; D008875:Middle Aged; D010950:Plasma Cells / Q000378:metabolism* / Q000648:ultrastructure; D013194:Staining and Labeling / Q000379:methods
chemical_list: D007501:Iron