[Value of inhibin as a tumor marker in granulosa cell tumors. Apropos of 6 new cases treated at the Gustave-Roussy Institute].
Lappöhn et al showed that inhibin can be used as a marker of granulosa cell tumors (GCT). Inhibin ia s glycoprotein specifically produced by ovarian granulosa cells. This peptide has been given in six women of 45 patients with a GCT who were referred for treatment or judgment in the Institut Gustave Roussy of Villejuif. Inhibin remained undetectable in four patients without evidence of disease. In one of them, inhibin level decreased progressively after surgical resection (for 10 months). Inhibin was also given in two patients with recurrence: in one case inhibin level was very high, and in one case it was barely detectable. In finding with other publications, inhibin can be used as a maker for reccurent disease, when patients are menopaused even when tumor does not produce steroids.
Pautier
P
P
Service de gynécologie médicale, institut Gustave-Roussy, Villejuif, France.
Bidart
J M
JM
Lallou
N
N
Duvillard
P
P
Michel
G
G
Droz
J P
JP
Lhommé
C
C
D000328:Adult; D014408:Biomarkers, Tumor / Q000097:blood*; D005260:Female; D005602:France; D006106:Granulosa Cell Tumor / Q000097:blood*; D006801:Humans; D007265:Inhibins / Q000097:blood* / Q000502:physiology; D008597:Menstrual Cycle; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D010051:Ovarian Neoplasms / Q000097:blood*; D011863:Radioimmunoassay; D012189:Retrospective Studies
D014408:Biomarkers, Tumor; D007265:Inhibins