title: Partial volume effects in volume-localized phased-array proton spectroscopy of the temporal lobe.
abstract: MRS techniques can aide in confirming the location of seizure foci in temporal lobe epilepsy. N-acetyl aspartate (NAA), creatine plus phosphocreatine, choline-containing compounds, and lactate are most often the clinically relevant metabolites in these studies. We examined the importance of partial volume effects from tissue heterogeneity in temporal lobe spectroscopy on the metabolite ratios. Our study shows that localized spectroscopy, using three different voxel sizes, centered on the anterior body of the hippocampus, produces significantly different values for the NAA to the creatine ratio. The spectroscopy was performed at 1.5 T using the PRESS pulse sequence and a phased-array coil system specifically designed for the temporal lobe. The data exhibits a clear trend of increasing NAA to creatine ratios with increasing voxel size. This trend demonstrates that partial volume effects can contribute to variation of NAA to creatine ratios in healthy subjects.
authors.affiliation: Center for Bioengineering, University of Washington, Seattle 98195, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Strauss
authors.forename: J S
authors.initials: JS
authors.lastname: Tsuruda
authors.forename: T L
authors.initials: TL
authors.lastname: Richards
mesh_terms: D016477:Artifacts; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D004833:Epilepsy, Temporal Lobe / Q000378:metabolism; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D019047:Phantoms, Imaging; D010725:Phosphocreatine / Q000032:analysis; D013702:Temporal Lobe / Q000737:chemistry*
chemical_list: D010725:Phosphocreatine; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline