title: CD44 is expressed throughout pre-implantation human embryo development.
abstract: The cell surface glycoprotein CD44 has been demonstrated in a variety of cell types in embryonic and adult tissues. We have established that CD44 is present on human oocytes, cumulus cells, early embryos and pre-hatched blastocysts by indirect immunofluorescence. We have also shown that CD44 is present on 8-11 week placental stroma cells, but not on the trophoblast. These findings demonstrate that CD44 is present throughout preimplantation development, and that down-regulation occurs on the embryonic surface after implantation.
authors.affiliation: Department of Obstetrics and Gynaecology, University Hospital of South Manchester, UK.
authors.forename: S
authors.initials: S
authors.lastname: Campbell
authors.forename: H R
authors.initials: HR
authors.lastname: Swann
authors.forename: J D
authors.initials: JD
authors.lastname: Aplin
authors.forename: M W
authors.initials: MW
authors.lastname: Seif
authors.forename: S J
authors.initials: SJ
authors.lastname: Kimber
authors.forename: M
authors.initials: M
authors.lastname: Elstein
mesh_terms: D001755:Blastocyst / Q000378:metabolism* / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D018960:Hyaluronan Receptors; D016023:Integrins / Q000378:metabolism; D010920:Placenta / Q000166:cytology / Q000378:metabolism; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011956:Receptors, Cell Surface / Q000378:metabolism*; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism*; D013194:Staining and Labeling; D017154:Stromal Cells / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism
chemical_list: D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D016023:Integrins; D011956:Receptors, Cell Surface; D016201:Receptors, Lymphocyte Homing