[Regularities of radiation effects in ontogenesis of progeny of the 1st generation of Wistar rats after irradiation of germ cells of both parents at different stages of gametogenesis].
The data on antenatal and postnatal periods of ontogenesis of the posterity of the first generation of Wistar rats exposed by doses of 2-4 Gy at various terms before conception showed that the realization of radiation effects depended on the stage of gametogenesis of sex cells of both parents at radiation exposure. Stimulating radiation effect (hyperovulation) is accompanied by the higher rate of antenatal and early postnatal death of the posterity. In the rest cases it died mainly at embryogenesis. The most unfavourable factor for ontogenesis of the posterity appeared to be a participation in the fertilization of sex cells exposed at postmeiotic stages of gametogenesis, with the degree of manifestation of radiation effects depending on radiation dose.
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D000818:Animals; D000831:Animals, Newborn; D005260:Female; D005718:Gametogenesis / Q000528:radiation effects*; D008297:Male; D010063:Ovum / Q000528:radiation effects*; D011247:Pregnancy; D011829:Radiation Dosage; D011833:Radiation Injuries, Experimental; D051381:Rats; D017208:Rats, Wistar; D013094:Spermatozoa / Q000528:radiation effects*; D013997:Time Factors