title: Secretory symptoms from metastatic adrenal cortical carcinoma responding to octreotide.
abstract: The prognosis of patients with metastatic adrenal cortical carcinoma is poor, and their disabling symptoms are usually unresponsive to conventional therapy. A patient with Cushing's syndrome secondary to a secretory adrenal cortical carcinoma was treated with octreotide, endocrine therapy and chemotherapy having failed. Treatment led to a dramatic relief of her symptoms with a fall in corticosteroid secretion. Somatostatin analogue therapy for this tumour should be encouraged in view of the lack of alternative palliative treatment.
authors.affiliation: Department of Clinical Oncology, Hammersmith Hospital, London, UK.
authors.forename: H S
authors.initials: HS
authors.lastname: Pandha
authors.forename: K
authors.initials: K
authors.lastname: Harrington
authors.forename: S
authors.initials: S
authors.lastname: Saini
authors.forename: J
authors.initials: J
authors.lastname: Lynn
authors.forename: M
authors.initials: M
authors.lastname: Peters
authors.forename: J
authors.initials: J
authors.lastname: Waxman
mesh_terms: D000306:Adrenal Cortex Neoplasms / Q000150:complications*; D003480:Cushing Syndrome / Q000188:drug therapy*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000652:urine; D008875:Middle Aged; D015282:Octreotide / Q000627:therapeutic use*; D010166:Palliative Care; D013739:Testosterone / Q000097:blood; D013997:Time Factors; D016896:Treatment Outcome
chemical_list: D013739:Testosterone; D015282:Octreotide; D006854:Hydrocortisone