title: C-CAM expression in odontogenesis and tooth eruption.
abstract: The distribution of the cell adhesion molecule C-CAM was analyzed during tooth development, eruption and formation of the junctional epithelium in rat molars by immunohistochemistry and in situ hybridization. C-CAM could not be detected during odontogenesis until the late bell stage; then only the mRNA was demonstrated in the odontoblasts and ameloblasts. Prior to eruption, a local increase in C-CAM (mRNA and protein) was observed in the reduced enamel epithelium. During eruption, high C-CAM levels were seen in the fusion zone between the oral epithelium and the reduced enamel epithelium. In the adult rat, C-CAM remained strongly expressed in the junctional epithelium. Our study indicates that C-CAM may play a role in odontogenesis and during formation of the epithelial structures involved in tooth eruption and formation of the junctional epithelium.
authors.affiliation: Dept. Cell Mol. Biol., Medical Nobel Institute, Karolinska Institutet, Stockholm, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Lüning
authors.forename: J
authors.initials: J
authors.lastname: Wroblewski
authors.forename: B
authors.initials: B
authors.lastname: Obrink
authors.forename: L
authors.initials: L
authors.lastname: Hammarström
authors.forename: B
authors.initials: B
authors.lastname: Rozell
mesh_terms: D000565:Ameloblasts / Q000378:metabolism; D000818:Animals; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D003743:Dental Enamel / Q000378:metabolism; D004846:Epithelial Attachment / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D009804:Odontoblasts / Q000378:metabolism; D009805:Odontogenesis / Q000235:genetics; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D014078:Tooth Eruption / Q000235:genetics; D014083:Tooth Germ / Q000378:metabolism
chemical_list: D015815:Cell Adhesion Molecules; D012333:RNA, Messenger