Cytokine-processing enzymes. Stopping the cuts.
The recently discovered enzymes that process the precursors of inflammatory cytokines are good targets for the design of new anti-inflammatory therapeutic agents.
Dinarello
C A
CA
Department of Medicine, Tufts University, Boston, Massachusetts 02111, USA.
Margolis
N H
NH
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D017209:Apoptosis / Q000502:physiology; D020170:Caspase 1; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D016207:Cytokines / Q000096:biosynthesis*; D015195:Drug Design; D006801:Humans; D007249:Inflammation / Q000378:metabolism; D008666:Metalloendopeptidases / Q000037:antagonists & inhibitors; D051379:Mice; D018345:Mice, Knockout; D011480:Protease Inhibitors / Q000494:pharmacology*; D011498:Protein Precursors / Q000378:metabolism*; D011499:Protein Processing, Post-Translational / Q000187:drug effects*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016207:Cytokines; D011480:Protease Inhibitors; D011498:Protein Precursors; D003546:Cysteine Endopeptidases; D020170:Caspase 1; D008666:Metalloendopeptidases