Kluver-Bucy syndrome: report of a case with nasopharyngeal cancer after irradiation and chemotherapy.
A case of Kluver-Bucy syndrome associated with delayed cerebral necrosis after radiation therapy and chemotherapy is reported. The patient--a 51-year-old man who was a victim of nasopharyngeal cancer--developed a complex behavioral disturbance consisting of visual agnosia, alteration of sexual behavior, strong oral tendency, placidity, memory deficit and speech disturbance one year after two courses of irradiation and chemotherapy. Brain computed tomography disclosed bilateral temporal hypodensity with edema. The patient expired from cachexia three months later. The clinical picture fulfilled the criteria of Kluver-Bucy syndrome. It should be emphasized that this syndrome may occur after irradiation and chemotherapy in patients with nasopharyngeal cancer.
Chu
C C
CC
Department of Neurology, Chang Gung Memorial Hospital and Medical College, Taipei, Taiwan, R.O.C.
Huang
C C
CC
Chen
H J
HJ
D000377:Agnosia / Q000209:etiology*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001761:Bleomycin / Q000008:administration & dosage; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy / Q000532:radiotherapy*; D002945:Cisplatin / Q000008:administration & dosage; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000209:etiology*; D008875:Middle Aged; D009303:Nasopharyngeal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy*; D019965:Neurocognitive Disorders / Q000209:etiology*; D011832:Radiation Injuries / Q000209:etiology*; D011878:Radiotherapy / Q000009:adverse effects; D013577:Syndrome
D001761:Bleomycin; D002945:Cisplatin