title: Immunologic tolerance: development and disruption.
abstract: Loss of tolerance to self-antigens is thought to have a role in a variety of common diseases. Studies in animal models of such diseases as systemic lupus erythematosus have provided new insights into how self-tolerance is broken or bypassed and how it may be restored. These and other experiments also are clarifying how self-tolerance is normally established; the T lymphocyte appears to be the dominant player.
authors.affiliation: Department of Immunology, Scripps Research Institute, La Jolla, Calif.
authors.forename: W O
authors.initials: WO
authors.lastname: Weigle
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology; D001327:Autoimmune Diseases / Q000517:prevention & control; D015551:Autoimmunity / Q000276:immunology*; D017635:Clonal Anergy / Q000276:immunology; D017637:Clonal Deletion / Q000276:immunology; D006801:Humans; D017634:Self Tolerance / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D005719:gamma-Globulins / Q000627:therapeutic use
chemical_list: D005719:gamma-Globulins