title: Effect of lindane on galactose and leucine transport in chicken enterocytes.
abstract: Lindane (gamma-hexachlorocyclohexane) influence on the in vitro intestinal transport of D-galactose and L-leucine has been studied in isolated chicken enterocytes. Animals were injected i.p. with 30 mg/kg b.w. of the pesticide over 7 days. Total uptake of D-galactose and L-leucine was significantly decreased by lindane action. There was no alteration in the non-mediated component, but the mediated transport was markedly inhibited in both cases. Furthermore, the exit of D-galactose across the basolateral membrane, as well as (Na(+)-K+)-ATPase activity, was significantly decreased in pesticide-treated chickens.
authors.affiliation: Department of Physiology and Nutrition, Faculty of Pharmacy, University of Navarra, Pamplona, Spain.
authors.forename: M J
authors.initials: MJ
authors.lastname: Moreno
authors.forename: S
authors.initials: S
authors.lastname: Pellicer
authors.forename: A
authors.initials: A
authors.lastname: Marti
authors.forename: J C
authors.initials: JC
authors.lastname: Arenas
authors.forename: M P
authors.initials: MP
authors.lastname: Fernández-Otero
mesh_terms: D000818:Animals; D001692:Biological Transport; D002645:Chickens; D005690:Galactose / Q000378:metabolism*; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D066298:In Vitro Techniques; D007583:Jejunum / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D007930:Leucine / Q000378:metabolism*; D008297:Male; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
chemical_list: D001556:Hexachlorocyclohexane; D000254:Sodium-Potassium-Exchanging ATPase; D007930:Leucine; D005690:Galactose