Recurrent dermopathy after remission of Stevens-Johnson syndrome secondary to mild dermal trauma.
We report on three patients who had an apparent recurrence of the dermatitis of Stevens-Johnson Syndrome (SJS) after remission had been induced with corticosteroids. The recurrences were related to mild trauma to the skin, including the Red Man Syndrome, after vancomycin in two patients. Both responded to corticosteroids, and vancomycin could be continued with modification in the rate of infusion. The third patient had dry, pruritic skin and the exacerbation of SJS appeared related to the trauma associated with intense scratching. A post SJS inflammatory dermatitis may occur after remission of SJS secondary to cutaneous trauma. This recurrent SJS dermopathy is rapidly responsive to moderate dose corticosteroid therapy.
Patterson
R
R
Department of Medicine, Northwestern University Medical School, Chicago, IL 60611, USA.
Cheriyan
S
S
Greenberger
P A
PA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000493:Allopurinol / Q000009:adverse effects; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005260:Female; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D010672:Phenytoin / Q000009:adverse effects; D010878:Piperacillin / Q000009:adverse effects; D011379:Prognosis; D012008:Recurrence; D012867:Skin / Q000293:injuries; D013262:Stevens-Johnson Syndrome / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D014640:Vancomycin / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D005938:Glucocorticoids; D010672:Phenytoin; D000493:Allopurinol; D014640:Vancomycin; D010878:Piperacillin