Impairment of long-term potentiation in rats fed with vitamin E-deficient diet.
Our previous results indicate that alpha-tocopherol induces a slowly developing long-term potentiation (LTP) of excitatory postsynaptic potentials (EPSP) in hippocampal slices. In the present study on hippocampal slices obtained from rats fed with vitamin E-deficient diet for 3 months, a tetanic stimulation of the stratum radiatum or applied alpha-tocopherol phosphate failed to induce LTP of CA1 neuronal EPSPs. However, LTP could be induced in rats fed on a matching control diet. These results indicate that vitamin E-deficiency leads to an impairment in LTP induction.
Xie
Z
Z
Department of Pharmacology and Therapeutics, Faculty of Medicine, University of British Columbia, Vancouver, Canada.
Sastry
B R
BR
D000818:Animals; D004032:Diet; D004558:Electric Stimulation; D004594:Electrophysiology; D005071:Evoked Potentials / Q000187:drug effects; D006624:Hippocampus / Q000166:cytology / Q000502:physiology; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D018408:Patch-Clamp Techniques; D051381:Rats; D017208:Rats, Wistar; D014810:Vitamin E / Q000494:pharmacology; D014811:Vitamin E Deficiency / Q000503:physiopathology*
D014810:Vitamin E