[Muramyl peptides and sleep].
Effects of muramyl peptides from bacterial cell walls (MDP and GMDP), their fragments, steric isomers and structural analogues were studied on sleep in rabbits. An increase in the SWS, decrease in PS, rise in body temperature were found following minimal doses, whereas pathological responses in the EEG and sleep as well as pyrogenic effects occurred after higher doses. The GMDP analogues affected sleep weakly, and isomers and fragments were inactive. Possible role of muramyl peptides in normal and pathological regulation of sleep is discussed.
Koval'zon
V M
VM
Obal
F
F
Johannsen
L
L
Krueger
J M
JM
Andronova
T M
TM
D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D002540:Cerebral Cortex / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects; D004576:Electromyography / Q000187:drug effects; D004585:Electrooculography / Q000187:drug effects; D006020:Glycopeptides / Q000494:pharmacology*; D007536:Isomerism; D010446:Peptide Fragments / Q000494:pharmacology*; D011817:Rabbits; D012890:Sleep / Q000187:drug effects* / Q000502:physiology; D013329:Structure-Activity Relationship
D006020:Glycopeptides; D010446:Peptide Fragments