Suppression of splenic enzyme activities by administration of aminopeptidase N (CD13) inhibitors: relationship between actions in vivo and in vitro.
The enzymatic changes in murine spleen caused by the administration for 20 successive days of various inhibitors of aminopeptidase N (leucocyte antigen CD13) have been compared. When compared with the control (saline), most of the inhibitors significantly suppressed splenic enzyme activities including those of ectoenzymes. A multivariate study indicated that the in vivo effects of the inhibitors were closely related to their inhibitory actions in vitro.
Kocha
T
T
Showa College of Pharmaceutical Sciences, Tokyo, Japan.
Ohtsuka
E
E
Funahashi
T
T
Fukuda
T
T
Aoyagi
T
T
Wanda
T
T
Takeuchi
T
T
D000596:Amino Acids / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D018826:CD13 Antigens / Q000378:metabolism*; D010450:Endopeptidases / Q000378:metabolism; D006026:Glycoside Hydrolases / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology; D006877:Hydroxamic Acids / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D007930:Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides; D011480:Protease Inhibitors / Q000494:pharmacology*; D013154:Spleen / Q000187:drug effects / Q000201:enzymology*
D000596:Amino Acids; D000900:Anti-Bacterial Agents; D006146:Guanidines; D006877:Hydroxamic Acids; D007093:Imidazoles; D009842:Oligopeptides; D010455:Peptides; D011480:Protease Inhibitors; C063432:probestin; C069912:leuhistin; C016977:amastatin; C040038:arphamenine A; D006026:Glycoside Hydrolases; D010450:Endopeptidases; D018826:CD13 Antigens; D007930:Leucine; C012211:ubenimex; C010531:actinonin