title: Clinico-pathological criteria with prognostic relevance in hepatoblastoma.
abstract: We investigated clinical data and histological specimens of 46 patients with a hepatoblastoma (HB) for prognostic criteria. Disease-free survival (DFS) of 23 patients treated in the German Cooperative Study HB-89 (1988-1990) was 83%, in contrast to 40% in 10 children with other chemotherapy regimes (1977-1987) and 38% in 13 with only a tumour resection (P = 0.005). Tumour residence after resection (R category) correlated significantly with probability of DFS (P = 0.0001). This was also the case for pT status, according to the pTNM classification for liver carcinoma (P = 0.0007), involvement of one or both liver lobes (P = 0.004), multiplicity of tumour nodes (P = 0.001), vascular invasion (P = 0.0006) and expression of nucleolar organiser regions as an indicator for proliferation activity of tumour cells (P = 0.05). Patients' age and histopathological subtypes could only indicate outcome, while tumour size and serum alpha-fetoprotein values were not significantly related to prognosis. In multivariate analysis, pT status and R categories remained significant. These should be applied in all cooperative trials on HB.
authors.affiliation: Department of Pediatric Surgery, Medical School Hannover, Germany.
authors.forename: D
authors.initials: D
authors.lastname: von Schweinitz
authors.forename: P
authors.initials: P
authors.lastname: Wischmeyer
authors.forename: I
authors.initials: I
authors.lastname: Leuschner
authors.forename: D
authors.initials: D
authors.lastname: Schmidt
authors.forename: C
authors.initials: C
authors.lastname: Wittekind
authors.forename: D
authors.initials: D
authors.lastname: Harms
authors.forename: H
authors.initials: H
authors.lastname: Mildenberger
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D018197:Hepatoblastoma / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D006801:Humans; D007223:Infant; D008113:Liver Neoplasms / Q000401:mortality / Q000473:pathology* / Q000628:therapy; D008297:Male; D009697:Nucleolus Organizer Region; D011379:Prognosis; D015996:Survival Rate; D000509:alpha-Fetoproteins / Q000032:analysis
chemical_list: D000509:alpha-Fetoproteins