title: Simple hyperaemia test as a screening method in the postoperative surveillance of infrainguinal in situ vein bypasses.
abstract: OBJECTIVE
  To develop a simple protocol for ultrasound Duplex surveillance of infrainguinal vein bypasses.
  
  
  METHODS
  The value of three Doppler waveform parameters, obtained from a single point of the bypass, for identification of stenoses was studied in 91 in situ vein bypasses. Midgraft peak systolic velocity (PSV), pulsatility index (PI) and ratio of hyperaemic and resting time-average mean velocities (TAMV), (TAMV ratio = TAMVhyperaemia/TAMVrest) were correlated with the presence and severity of stenoses as assessed by conventional Duplex scanning and ankle-brachial index (ABI) measurements. The optimal value of the waveform parameters for discrimination between bypasses with and without evidence of stenoses was determined by receiver operating characteristics (ROC) analysis.
  
  
  RESULTS
  Complete Duplex scanning of the entire graft revealed an increase in the peak systolic velocity by a factor 2.5 indicative of significant stenoses in 24 (26%) patients. A PSV below 55 cm/s was a poor indicator of stenoses (sensitivity 46%, specificity 76%) and PI < or = 3.8 only allowed suboptimal discrimination between normal and stenotic bypasses (sensitivity 63%, specificity 75%). The hyperaemic response assessed by TAMV ratio proved the best parameter for identification of graft stenoses. A TAMV ratio of 2.0 or less correctly identified 21 of the 24 lesions (sensitivity 88%, specificity 75%) and none of the three bypasses with evidence of stenoses and TAMV ratios exceeding 2.0 failed during follow-up.
  
  
  CONCLUSIONS
  Single point waveform analysis of vein bypass velocity profile at rest and during reactive hyperaemia is a simple screening method providing diagnostic and prognostic information which may be of value in the postoperative surveillance of infrainguinal vein bypasses.
authors.affiliation: Department of Vascular Surgery RK, Rigshospitalet, University of Copenhagen, Denmark.
authors.forename: T G
authors.initials: TG
authors.lastname: Nielsen
authors.forename: H
authors.initials: H
authors.lastname: Sillesen
authors.forename: T V
authors.initials: TV
authors.lastname: Schroeder
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001783:Blood Flow Velocity; D003251:Constriction, Pathologic / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D005500:Follow-Up Studies; D006083:Graft Occlusion, Vascular / Q000000981:diagnostic imaging* / Q000503:physiopathology; D006119:Groin; D006801:Humans; D006940:Hyperemia / Q000000981:diagnostic imaging* / Q000503:physiopathology; D007866:Leg / Q000098:blood supply* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D011150:Popliteal Artery / Q000601:surgery; D012372:ROC Curve; D012501:Saphenous Vein / Q000637:transplantation; D012680:Sensitivity and Specificity; D018709:Statistics, Nonparametric; D018616:Ultrasonography, Doppler, Duplex / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data