Inhibition by ginseng total saponin of the development of morphine reverse tolerance and dopamine receptor supersensitivity in mice.
1. Ginseng total saponin (GTS), 200 mg/kg i.p. 3 hr prior to morphine, inhibited the development of reverse tolerance to the ambulatory-accelerating effect of morphine. 2. GTS, 200 mg/kg, also prevented the development of dopamine receptor supersensitivity induced by the chronic administration of morphine, 10 mg/kg a day for 7 days. 3. These results suggest that GTS may be useful for the prevention and therapy of the adverse action of morphine.
Kin
H S
HS
Department of Pharmacology, College of Pharmacy, Chungbuk National University, Cheongju, Korea.
Kang
J G
JG
Oh
K W
KW
D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D004361:Drug Tolerance; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D009020:Morphine / Q000494:pharmacology*; D009043:Motor Activity / Q000187:drug effects; D005894:Panax; D010946:Plants, Medicinal; D011954:Receptors, Dopamine / Q000187:drug effects*; D012503:Saponins / Q000494:pharmacology*
D011954:Receptors, Dopamine; D012503:Saponins; D009020:Morphine; D001058:Apomorphine