[Molecular cloning of a new AP-2 transcription factor, AP-2beta, and its function in cell differentiation].
Transcription factor AP-2 has been previously shown to play an important function in embryonal development and cell differentiation. We have investigated the possibility that AP-2 function in embryonic development is exerted by a multigene family of AP-2 related transcription factors. Here we describe the molecular cloning of such an AP-2 related gene, AP-2 beta, and prove that it encodes for a functional transcription factor. In situ hybridizations of murine embryo sections revealed a temporally restricted and tissue-specific expression pattern that indicates a function of AP-2 beta in the development of the midbrain in the differentiation of sensory neurons for taste, olfaction and palpation.
Buettner
R
R
Institut für Pathologie, Universität Regensburg.
Moser
M
M
Pscherer
A
A
Imhof
A
A
Bauer
R
R
Hofstaedter
F
F
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics*; D003001:Cloning, Molecular; D004268:DNA-Binding Proteins / Q000096:biosynthesis* / Q000302:isolation & purification; D004622:Embryo, Mammalian; D015698:Genomic Library; D006801:Humans; D017403:In Situ Hybridization; D008636:Mesencephalon / Q000166:cytology / Q000196:embryology*; D051379:Mice; D009474:Neurons / Q000166:cytology / Q000502:physiology*; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000302:isolation & purification; D050656:Transcription Factor AP-2; D014157:Transcription Factors / Q000096:biosynthesis* / Q000302:isolation & purification
D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D011994:Recombinant Proteins; C493677:TFAP2B protein, human; C493669:Tfap2b protein, mouse; D050656:Transcription Factor AP-2; D014157:Transcription Factors