title: [The antiviral aerosol aprotinin. General effect on the body after inhalation administration].
abstract: A new medicine for the treatment of respiratory viral infections is described. It contains aprotinin, a natural inhibitor of proteases, and is used in the form of a fine aerosol for inhalation or intra-respiratory instillation. To estimate its innocuousness, the inhalation effect of the aerosol was studied on animals of two species. The experiments included examination of the functional state of the central nervous and cardiovascular systems, determination of the blood cell composition and biochemical blood count, morphological and histological investigation of the internal organs. The toxicological studies showed that aprotinin inhalation induced no adverse reactions which made it possible to recommend the aprotinin inhalation for the use in the treatment and prophylaxis of infections caused by a wide variety of respiratory viruses in humans.
authors.forename: O P
authors.initials: OP
authors.lastname: Zhirnov
authors.forename: A V
authors.initials: AV
authors.lastname: Ovcharenko
authors.forename: P B
authors.initials: PB
authors.lastname: Goliando
authors.forename: T P
authors.initials: TP
authors.lastname: Svinogeeva
authors.forename: G V
authors.initials: GV
authors.lastname: Dolgova
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D007611:Aprotinin / Q000494:pharmacology*; D001772:Blood Cell Count / Q000187:drug effects; D002319:Cardiovascular System / Q000187:drug effects*; D002490:Central Nervous System / Q000187:drug effects*; D005260:Female; D008297:Male; D011817:Rabbits; D051381:Rats
chemical_list: D000336:Aerosols; D000998:Antiviral Agents; D007611:Aprotinin