title: Regulation of an anti-polysaccharide immune response in BALB/c mice through a tight T and B lymphocyte idiotypic connection.
abstract: The isotype expression in the J558 idiotype-associated humoral immune response against alpha(1-->3)-dextran in BALB/c mice is controlled by idiotype-specific T cells which silence in situ B lymphocytes primed and committed to an IgG response. This leads to a restriction of the type II thymus-independent response to the sole production of IgM antibodies. The availability of the T cell receptor (TcR) alpha and beta sequences for such a regulatory T cell clone allows the investigation of the degree of heterogeneity of the TcR usage of these T cells. It is found that all alpha(1-->3)-dextran-primed BALB/c mice use a very similar, possibly identical TcR. This suggests a tight, possibly genetically programmed, interaction between the J558 idiotype-bearing dextran-specific B cells and their idiotype-specific regulatory T cell counterparts.
authors.affiliation: Institut für Immunologie, Universität Münster, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Rademaekers
authors.forename: E
authors.initials: E
authors.lastname: Kölsch
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D001483:Base Sequence; D003911:Dextrans / Q000276:immunology*; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D007075:Immunoglobulin M / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D003911:Dextrans; D007130:Immunoglobulin Idiotypes; D007075:Immunoglobulin M