title: Screening in general practice.
abstract: Screening for prostate cancer in a general practice setting seems to be technically feasible and generally acceptable. In our study, 14 cancers were diagnosed among the 568 men screened, giving an overall detection rate of 2%; five of these were either locally advanced or associated with metastatic disease. Although these results may reflect our somewhat conservative biopsy rate, there is a considerable false positive rate in the PSA range of 4-10 ng/ml, particularly among men with clinical evidence of benign prostatic hyperplasia. A large scale prospective controlled study will be necessary to establish the true benefit of screening.
authors.affiliation: Department of Urology, St Bartholomew's Hospital, West Smithfield, London.
authors.forename: M R
authors.initials: MR
authors.lastname: Feneley
authors.forename: M G
authors.initials: MG
authors.lastname: Kirby
authors.forename: T
authors.initials: T
authors.lastname: McNicholas
authors.forename: A
authors.initials: A
authors.lastname: McLean
authors.forename: J A
authors.initials: JA
authors.lastname: Webb
authors.forename: R S
authors.initials: RS
authors.lastname: Kirby
mesh_terms: D000368:Aged; D005194:Family Practice; D006801:Humans; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen