title: Carcinoma of the pyriform sinus: a retrospective analysis of treatment results over a 20-year period.
abstract: One hundred and one patients with pyriform sinus carcinoma treated at the Netherlands Cancer Institute were studied retrospectively. The patients were staged according to the UICC criteria of 1987: there were no stage I, 23 stage II, 30 stage III, and 48 stage IV patients. The treatment consisted of radiotherapy (n = 45), a planned combination of surgery and post-operative radiotherapy (n = 47) or surgery alone (n = 9). The crude 5-year survival was 27%, whereas the 5-year disease-free survival was 37%. The locoregional disease-free survival was 52%. Stage according to the UICC 1987 criteria is an important prognostic variable (P = 0.0026). Furthermore, significantly less locoregional recurrences and a better disease-free survival were seen in the combined surgery and radiotherapy group than in the exclusively irradiated group (P < 0.0001).
authors.affiliation: Department of Otolaryngology-Head & Neck Surgery, The Netherlands Cancer Institute, Amsterdam.
authors.forename: M M
authors.initials: MM
authors.lastname: Elias
authors.forename: F J
authors.initials: FJ
authors.lastname: Hilgers
authors.forename: R B
authors.initials: RB
authors.lastname: Keus
authors.forename: R T
authors.initials: RT
authors.lastname: Gregor
authors.forename: A A
authors.initials: AA
authors.lastname: Hart
authors.forename: A J
authors.initials: AJ
authors.lastname: Balm
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007012:Hypopharyngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D007013:Hypopharynx / Q000473:pathology / Q000528:radiation effects / Q000601:surgery; D007822:Laryngeal Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D007830:Larynx / Q000473:pathology / Q000528:radiation effects / Q000601:surgery*; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D015996:Survival Rate; D016896:Treatment Outcome