Self-determinants in autoimmune demyelinating disease: changes in T- cell response specificity.
Recent research developments support the following views regarding antigen recognition in autoimmune demyelinating disease: there may be no single autoimmune target protein; diverse peptide self-determinants from multiple myelin proteins can be recognized; target determinant epitopes may differ among individuals; and target epitope recognition can change with time during the course of disease.
Tuohy
V K
VK
Cleveland Clinic Foundation, Department of Immunology, OH 44195.
Fritz
R B
RB
Ben-Nun
A
A
D000818:Animals; D001324:Autoantigens / Q000276:immunology*; D015551:Autoimmunity / Q000276:immunology; D003711:Demyelinating Diseases; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D009103:Multiple Sclerosis / Q000276:immunology*; D009185:Myelin Proteins / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D001324:Autoantigens; D000939:Epitopes; D009185:Myelin Proteins