Combinatorial libraries: new insights into human organ-specific autoantibodies.
The recent application of immunoglobulin (Ig) gene combinatorial library technology has led to a logarithmic increase in information concerning human, disease-associated, organ-specific autoantibodies of the IgG class. As reviewed here by Basil Rapoport, Stefano Portolano and Sandra McLachlan, the molecular cloning, analysis and expression of the genes for increasing numbers of these human, monoclonal autoantibodies is providing new insight into the genetic background and epitopic repertoires of such molecules.
Rapoport
B
B
Thyroid Molecular Biology Unit, Veterans' Administration Medical Center, San Francisco, CA.
Portolano
S
S
McLachlan
S M
SM
D000911:Antibodies, Monoclonal / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D000939:Epitopes / Q000276:immunology; D015723:Gene Library; D005803:Genes, Immunoglobulin / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology
D000911:Antibodies, Monoclonal; D001323:Autoantibodies; D000939:Epitopes; D007074:Immunoglobulin G