Effect of domoic acid on metabolism of 5-hydroxytryptamine in rat brain.
Domoic acid (Dom) is a neurotoxic secondary amino acid that interacts with the glutamate receptors, producing neurological problems. In the present work, we study the effects of Dom on the levels of serotonin (5-HT) and 5-hydroxyindoleacetic acid (5-HIAA) in discrete rat brain regions. The effects of Dom on the brain metabolism of serotonin are also discussed in this paper. Dom stimulates the rat brain serotoninergic system, increasing differentially the synthesis and the catabolism of 5-HT and the elimination of 5-HIAA.
Arias
B
B
Departamento de Biología Fundamental, Facultad de Ciencias, Universidad de Vigo, Spain.
Arufe
M
M
Alfonso
M
M
Duran
R
R
D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009498:Neurotoxins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*
D009498:Neurotoxins; D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; C012301:domoic acid; D007608:Kainic Acid