5 alpha-Androstan-3 alpha,17 beta-diol is a hormone: stimulation of cAMP accumulation in human and dog prostate.
5 alpha-Androstan-3 alpha, 17 beta-diol (3 alpha-diol) is a well known metabolite of dihydrostestosterone (DHT) and the concentration of its glucuronide in serum is looked upon as a marker of DHT activity in skin and prostate. The data in this communication show that 3 alpha-diol is a potent agonist of the human and canine prostatic SHBG-[SHBG receptor]. It causes a robust rise in intracellular cAMP within minutes; the 1/2 max. response occurs at a concentration equal to its concentration in male plasma. Estradiol is the only other agonist in this system. All other steroids that bind to SHBG are antagonists.
Nakhla
A M
AM
Department of Medicine, St. Luke's/Roosevelt Hospital Center, New York, N.Y. 10019, USA.
Ding
V D
VD
Khan
M S
MS
Romas
N A
NA
Rhodes
L
L
Smith
R G
RG
Rosner
W
W
D015113:Androstane-3,17-diol / Q000494:pharmacology*; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism*; D004285:Dogs; D004958:Estradiol / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D008297:Male; D009924:Organ Culture Techniques; D011467:Prostate / Q000187:drug effects / Q000378:metabolism*; D011470:Prostatic Hyperplasia / Q000601:surgery; D011956:Receptors, Cell Surface / Q000819:agonists / Q000037:antagonists & inhibitors; D013237:Stereoisomerism
D011956:Receptors, Cell Surface; C063572:sex hormone-binding globulin receptor; D015113:Androstane-3,17-diol; D004958:Estradiol; D000242:Cyclic AMP