title: Primary sclerosing cholangitis with marked eosinophilic infiltration in the liver.
abstract: A 16-year-old boy was diagnosed as having primary sclerosing cholangitis (PSC), based on retrograde cholangiography showing mixed features of narrowing and dilatation of the common hepatic and intrahepatic bile ducts. However, periductal fibrosis was not observed in the needle biopsy liver specimen. The liver biopsy specimen obtained 11 years previously, at the onset of the disease had disclosed a marked infiltration of eosinophils in the portal tract with eosinophilic catinonic protein immunostaining, with marked eosinophilia (54%) being noted. In Japanese reports, eosinophilia of more than 7% was reported in 13 of 32 (40.6%) PSC patients. However, the early stage of PSC, with marked eosinophilia and eosinophilic infiltration in the liver, such as in the present case, has rarely been reported. The findings in this case suggest that eosinocytes are related to the pathogenesis of PSC.
authors.affiliation: Department of Internal Medicine II, Fukushima Medical College, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
authors.forename: H
authors.initials: H
authors.lastname: Ohira
authors.forename: M
authors.initials: M
authors.lastname: Kuroda
authors.forename: T
authors.initials: T
authors.lastname: Takagi
authors.forename: H
authors.initials: H
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Nishimaki
authors.forename: R
authors.initials: R
authors.lastname: Kasukawa
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
mesh_terms: D000293:Adolescent; D015209:Cholangitis, Sclerosing / Q000150:complications*; D004802:Eosinophilia / Q000150:complications* / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000473:pathology; D008297:Male