title: Blood filtration in children with severe sepsis: safe adjunctive therapy.
abstract: OBJECTIVE
  To review the safety and efficacy of haemofiltration and plasmafiltration in children with severe sepsis.
  
  
  METHODS
  Retrospective case notes analysis.
  
  
  METHODS
  University Paediatric Intensive Care Unit.
  
  
  METHODS
  All children admitted to the intensive care unit between November 1985 and May 1992 with a primary diagnosis of severe sepsis who also received blood filtration therapy.
  
  
  METHODS
  Continuous haemofiltration (HF) 18 patients; continuous haemofiltration and plasmafiltration (PF) 9 patients.
  
  
  RESULTS
  27 children with sepsis-induced MOSF, median age 26.6 months (range 0.33-185), median weight 12 kg (range 2.5-58), mean PRISM score 19.4 (SD 8.6), mean number of organs failing 2.78 (SD 0.9) received filtration for a median duration of 36 hours (range 2-145). Eight (30%) survived (HF 5/18, PF 3/9). There was no significant difference in the demographic features between the HF group and the PF group and no difference in mortality. The two groups were pooled to assess the effect of commencement of filtration on clinical wellbeing. Arterial blood gases, electrolytes, full blood examination, ventilator settings and doses of inotropes were recorded immediately prior to commencement of filtration and 18 h after commencement. Serum anion gap and osmolality were calculated using conventional formulae. There were no significant changes in the level of cardiorespiratory support, or biochemical markers of severity following commencement of filtration. Platelet count fell 32% (p = 0.029) but no bleeding was encountered. No severe complications were observed during 1222 h of filtration. No bleeding or infection was observed at the site of cannulation. One child developed haemodynamic instability following commencement of plasmafiltration necessitating abandonment of the procedure.
  
  
  CONCLUSIONS
  Haemofiltration or plasmafiltration can be performed safely in children with severe sepsis but their effect on outcome remains unknown.
authors.affiliation: Intensive Care Unit, Royal Childrens Hospital, Parkville, Victoria, Australia.
authors.forename: J H
authors.initials: JH
authors.lastname: Reeves
authors.forename: W W
authors.initials: WW
authors.lastname: Butt
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D006440:Hemofiltration / Q000009:adverse effects / Q000379:methods*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016555:Matched-Pair Analysis; D009102:Multiple Organ Failure / Q000401:mortality / Q000628:therapy*; D010951:Plasma Exchange / Q000009:adverse effects / Q000379:methods*; D012189:Retrospective Studies; D018805:Sepsis / Q000401:mortality / Q000628:therapy*; D012720:Severity of Illness Index; D016896:Treatment Outcome