Purification and cDNA sequence of a murine protein homologous to the human p62 tyrosine phosphoprotein that associates with the Ras GTPase-activating protein p120 GAP.
A 68-kDa protein that binds to the murine dendritic cell-specific monoclonal antibody M342 was purified and its amino acid sequence was partially determined. Corresponding cDNA clones code for a protein that is closely related to a 62-kDa human protein (p62) that associates with the Ras GTPase-activating protein, p120 GAP, suggesting that p62 may have a dendritic cell-specific function or that an M342 cross-reactive epitope may exist on the murine p62 molecule.
Agger
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R
Department of Medical Microbiology, Odense University, Denmark.
Freimuth
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P
D000595:Amino Acid Sequence; D000818:Animals; D000911:Antibodies, Monoclonal; D001483:Base Sequence; D018076:DNA, Complementary / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D003713:Dendritic Cells; D000939:Epitopes; D020690:GTPase-Activating Proteins; D015723:Gene Library; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D010750:Phosphoproteins / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D017421:Sequence Analysis; D017386:Sequence Homology, Amino Acid; D020703:ras GTPase-Activating Proteins; D018631:ras Proteins / Q000378:metabolism
D000911:Antibodies, Monoclonal; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; C489560:DOK1 protein, human; C489561:Dok1 protein, mouse; D000939:Epitopes; C074561:GAP-associated protein p62; D020690:GTPase-Activating Proteins; D010750:Phosphoproteins; D011506:Proteins; D016601:RNA-Binding Proteins; D020703:ras GTPase-Activating Proteins; D018631:ras Proteins