Neuronal localization of glutamate receptor subunits in the basolateral amygdala.
Antibodies to the NMDAR1 glutamate receptor subunit and the GluR1 and GluR2/3 subunits of the AMPA glutamate receptor were used to localize these receptor components in the basolateral amygdala (ABL) of the rat and monkey. A similar localization pattern was observed in both species. Pyramidal neurons exhibited high levels of NMDAR1 and GluR2/3 immunoreactivity (ir), but low levels of GluR1-ir. Some non-pyramidal cells exhibited high levels of NMDAR1-ir or GluR1-ir, but none exhibited significant levels of GluR2/3-ir. This differential localization of receptor subunits suggests that glutamate receptors will exhibit specific functional properties in distinct subpopulations of ABL neurons.
McDonald
A J
AJ
Department of Cell Biology and Neuroscience, University of South Carolina School of Medicine, Columbia 29208, USA.
D000679:Amygdala / Q000166:cytology / Q000378:metabolism*; D000818:Animals; D007150:Immunohistochemistry / Q000379:methods; D008253:Macaca mulatta; D009474:Neurons / Q000378:metabolism*; D017966:Pyramidal Cells / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D018091:Receptors, AMPA / Q000378:metabolism; D017470:Receptors, Glutamate / Q000145:classification / Q000378:metabolism*; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism; D013194:Staining and Labeling; D014018:Tissue Distribution
D018091:Receptors, AMPA; D017470:Receptors, Glutamate; D016194:Receptors, N-Methyl-D-Aspartate