Semiconduction of proteins as an attribute of the living state: the ideas of Albert Szent-Györgyi revisited in light of the recent knowledge regarding oxygen free radicals.
Oxyradicals have been considered as harmful byproducts causing molecular damage during aging. However, evidence is accumulating to show that the actual situation is more complex: the living state implicitly involves the production of oxyradicals. (1) Blast type cells produce much less oxyradicals than the differentiated ones, and an increased production of OH radicals induce differentiation of various lines of leukemia cells; meanwhile, their superoxide dismutase expression increases to a very high extent. (2) The supramolecular organization of the cells is developed by means of "useful" crosslinking effects OH radicals. (3) Repiratory inhibition of oxyradical production (KCN-intoxication, suffocation, etc.) would kill living organisms prior to the exhaustion of energy reserves. It is assumed that the continuous flux of OH radicals is a prerequisite for a electron delocalization on the proteins, which is a semiconduction of p-type, proposes already in 1941 by Albert Szent-Györgyi, and refuted on a "theoretical" basis. It has become clear by now that the carbon-based semiconduction is possible because diamond transistors are known to exist. The recently developed atomic force microscopy offers some real possibilities for experimental testing of this assumption. This concept may lead us to new horizons in interpretation of living functions, such as the basic memory mechanisms in brain cells and their impairment during aging.
Nagy
I Z
IZ
Verzár International Laboratory for Experimental Gerontology (VILEG), Hungarian Section, University Medical School, Debrecen.
D000375:Aging / Q000378:metabolism*; D000818:Animals; D005609:Free Radicals / Q000266:history / Q000378:metabolism; D049673:History, 20th Century; D006801:Humans; D008954:Models, Biological; D011506:Proteins / Q000266:history* / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000266:history* / Q000378:metabolism; D012666:Semiconductors / Q000266:history*
D005609:Free Radicals; D011506:Proteins; D017382:Reactive Oxygen Species