title: [Pharmacotherapeutic use of antipruritic drugs in skin diseases].
abstract: Pruritus is a predominant and serious phenomenon of various skin diseases. As mediators of pruritus, histamine, serotonin (hydroxytryptamine), eicosanoids, neuropeptides, cytokines and proteases are known. The symptomatic treatment of pruritus is variable. Glucocorticoids are well known antipruritic drugs. H1-antihistaminics are used frequently. But the efficacy of these drugs is questionable in dogs. Additionally, mast cell stabilisators, unsaturated fatty acids (i. e. primrose oil, fish oil) and other antipruritic agents (local anesthetics) are used.
authors.affiliation: Institut für Pharmakologie, Pharmazie und Toxikologie, Veterinärmedizinischen Fakultät der Universität Leipzig.
authors.forename: M
authors.initials: M
authors.lastname: Kietzmann
mesh_terms: D000779:Anesthetics, Local / Q000627:therapeutic use; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use; D000982:Antipruritics / Q000627:therapeutic use*; D016207:Cytokines / Q000502:physiology; D015777:Eicosanoids / Q000502:physiology; D010450:Endopeptidases / Q000502:physiology; D005228:Fatty Acids, Essential / Q000627:therapeutic use; D005395:Fish Oils / Q000627:therapeutic use; D005938:Glucocorticoids / Q000627:therapeutic use; D006636:Histamine Release; D008041:Linoleic Acids; D009479:Neuropeptides / Q000502:physiology; D031665:Oenothera biennis; D010938:Plant Oils; D011537:Pruritus / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D012701:Serotonin / Q000502:physiology; D012871:Skin Diseases / Q000188:drug therapy / Q000503:physiopathology / Q000662:veterinary*; D017965:gamma-Linolenic Acid
chemical_list: D000779:Anesthetics, Local; D000894:Anti-Inflammatory Agents, Non-Steroidal; D000982:Antipruritics; D016207:Cytokines; D015777:Eicosanoids; D005228:Fatty Acids, Essential; D005395:Fish Oils; D005938:Glucocorticoids; D008041:Linoleic Acids; D009479:Neuropeptides; D010938:Plant Oils; D012701:Serotonin; C028498:evening primrose oil; D017965:gamma-Linolenic Acid; D010450:Endopeptidases