[Expression of intercellular adhesion molecule-1 and vascular adhesion molecule-1 in kidney of patients with lupus nephritis and membranoproliferative glomerulonephritis].
Immunohistochemical and computer-imaging analysis techniques were used to detect the expression of intercellular adhesion molecule 1 (ICAM-1) and vascular adhesion molecule 1 (VCAM-1) in the kidney of 25 patients with lupus nephritis (LN) type IV and in 15 patients with membranoproliferative glomerulonephritis (MPGN) type I. Results showed that ICAM-1 and VCAM-1 expressions were increased significantly in the kidneys of patients with MPGN and LN and that ICAM-1 in the glomeruli of LN patients correlated well with glomerular endothelial cell proliferation. ICAM-1 and VCAM-1 may well take a role in the pathogenesis of LN and MPGN.
Chen
X
X
Department of Pathology, General Hospital of Chinese PLA, Beijing.
Xu
Q
Q
Tang
L
L
D015815:Cell Adhesion Molecules / Q000378:metabolism*; D002455:Cell Division; D015432:Glomerulonephritis, Membranoproliferative / Q000378:metabolism*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D008181:Lupus Nephritis / Q000378:metabolism*; D019010:Vascular Cell Adhesion Molecule-1
D015815:Cell Adhesion Molecules; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1