title: Serum protein polymorphism in Chuetas (Majorcan Jews)--GC, A2HS, ORM, ITI and HP.
abstract: A sample of 140 Chuetas (descendants of Majorcan Jews) were typed for the GC, A2HS, ORM, ITI and HP serum proteins. Studies on ORM and ITI markers have not yet been reported in other Jewish populations. The allele frequencies obtained were: GC*1 = 0.610; A2HS*1 = 0.787; ORM*F1 = 0.339; ORM*S = 0.497; ITI*1 = 0.581; ITI*2 = 0.414; HP*2FS = 0.625; HP*1S = 0.230; HP*1F = 0.135. Some rare variants were found in polymorphic frequencies (ORM*S1 = 0.043; ORMS*S2 = 0.096; A2HS*10 = 0.015). These results have been compared with those found in other Jewish and non-Jewish European populations. The relatively high frequency of the HP*2FS allele and the presence of ORM*S1 and ORM*S2 variants in Chuetas show the Jewish origin of this population. The frequencies of GC and A2HS in Chuetas are similar to those found in other surrounding non-Jewish populations. ITI results are similar to those found in the two European populations studied. HP frequencies suggest a Spanish admixture.
authors.affiliation: Dept. de Biologia Fonamental i Ciències de la Salut, Universitat de les Illes Blears, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Picornell
authors.forename: J A
authors.initials: JA
authors.lastname: Castro
authors.forename: M M
authors.initials: MM
authors.lastname: Ramon
mesh_terms: D000510:Alpha-Globulins / Q000235:genetics; D001798:Blood Proteins / Q000235:genetics*; D005787:Gene Frequency; D006242:Haptoglobins / Q000235:genetics; D006801:Humans; D007585:Jews / Q000235:genetics*; D009961:Orosomucoid / Q000235:genetics; D010641:Phenotype; D011110:Polymorphism, Genetic; D015842:Serine Proteinase Inhibitors / Q000235:genetics; D013030:Spain; D014809:Vitamin D-Binding Protein / Q000235:genetics; D060749:alpha-2-HS-Glycoprotein
chemical_list: C556354:AHSG protein, human; D000510:Alpha-Globulins; D001798:Blood Proteins; D006242:Haptoglobins; D009961:Orosomucoid; D015842:Serine Proteinase Inhibitors; D014809:Vitamin D-Binding Protein; D060749:alpha-2-HS-Glycoprotein; C011877:inter-alpha-inhibitor