title: FK 506 metabolism in human liver microsomes: investigation of the involvement of cytochrome P450 isozymes other than CYP3A4.
authors.affiliation: Department of Drug Metabolism, Merck Research Laboratories, Rahway, NJ.
authors.forename: B V
authors.initials: BV
authors.lastname: Karanam
authors.forename: S H
authors.initials: SH
authors.lastname: Vincent
authors.forename: D J
authors.initials: DJ
authors.lastname: Newton
authors.forename: R W
authors.initials: RW
authors.lastname: Wang
authors.forename: S H
authors.initials: SH
authors.lastname: Chiu
mesh_terms: D000368:Aged; D003276:Contraceptives, Oral / Q000494:pharmacology; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D007527:Isoenzymes / Q000037:antagonists & inhibitors / Q000378:metabolism*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology*; D009652:Norpregnenes / Q000494:pharmacology; D011994:Recombinant Proteins / Q000378:metabolism; D016559:Tacrolimus / Q000378:metabolism*
chemical_list: D003276:Contraceptives, Oral; D065607:Cytochrome P-450 Enzyme Inhibitors; D007527:Isoenzymes; D009652:Norpregnenes; D011994:Recombinant Proteins; C033273:Gestodene; D003577:Cytochrome P-450 Enzyme System; C104464:CYP3A protein, human; D051544:Cytochrome P-450 CYP3A; C510163:CYP3A4 protein, human; D016559:Tacrolimus