title: Novel mutation in 16S rRNA associated with streptomycin dependence in Mycobacterium tuberculosis.
abstract: Molecular characterization of a streptomycin-dependent mutant of Mycobacterium tuberculosis revealed the presence of a novel mutation in the rrs gene encoding 16S rRNA. Insertion of an additional cytosine in the 530 loop of 16S rRNA, a region known to be involved in streptomycin susceptibility and resistance, was associated with streptomycin dependence.
authors.affiliation: Unité de Génétique Moléculaire Bactérienne, Institut Pasteur, Paris, France.
authors.forename: N
authors.initials: N
authors.lastname: Honoré
authors.forename: G
authors.initials: G
authors.lastname: Marchal
authors.forename: S T
authors.initials: ST
authors.lastname: Cole
mesh_terms: D001483:Base Sequence; D004269:DNA, Bacterial / Q000737:chemistry; D004352:Drug Resistance, Microbial / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D009169:Mycobacterium tuberculosis / Q000187:drug effects / Q000235:genetics*; D009690:Nucleic Acid Conformation; D016133:Polymerase Chain Reaction; D012329:RNA, Bacterial / Q000235:genetics*; D012335:RNA, Ribosomal / Q000235:genetics*; D013307:Streptomycin / Q000494:pharmacology*
chemical_list: D004269:DNA, Bacterial; D012329:RNA, Bacterial; D012335:RNA, Ribosomal; D013307:Streptomycin