title: Mutagenicity of ethylene glycol ethers and of their metabolites in Salmonella typhimurium his-.
abstract: Ethylene glycol ethers, their aldehyde and their acid metabolites were evaluated for their mutagenicity with the Ames test. The Salmonella typhimurium his- tester strains TA 97a, TA 98, TA 100 and TA 102 were used with and without rat S9 mix. Ethylene glycol monomethyl ether, ethylene glycol monoethyl ether, ethylene glycol n-butyl ether and their corresponding aldehyde and acid derivatives were tested up to 10(-4) mol/plate (around 10 mg/plate) or up to cytotoxic concentrations. All tested substances gave negative results with TA 98, TA 100 and TA 102 either with or without S9 mix. In contrast, ethylene glycol n-butyl ether (EGBE) and the aldehyde metabolite of ethylene glycol monomethyl ether, methoxyacetaldehyde (MALD), displayed mutagenic potency in strain TA 97a with and without S9 mix at high concentrations. A significant number of revertants was obtained from 19 mumol/plate EGBE (2.2 mg/plate) and from 34 mumol/plate MALD (2.5 mg/plate). At these concentrations the level of revertants reached up to 7-fold and 3-fold the control values for EGBE and MALD respectively.
authors.affiliation: Centre des Sciences de l'Environnement, Metz, France.
authors.forename: J C
authors.initials: JC
authors.lastname: Hoflack
authors.forename: L
authors.initials: L
authors.lastname: Lambolez
authors.forename: Z
authors.initials: Z
authors.lastname: Elias
authors.forename: P
authors.initials: P
authors.lastname: Vasseur
mesh_terms: D000079:Acetaldehyde / Q000031:analogs & derivatives; D000085:Acetates / Q000737:chemistry / Q000633:toxicity; D019342:Acetic Acid; D001711:Biotransformation; D004987:Ethers / Q000633:toxicity; D005026:Ethylene Glycols / Q000378:metabolism / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000378:metabolism / Q000633:toxicity*; D012486:Salmonella typhimurium
chemical_list: D000085:Acetates; D004987:Ethers; D005026:Ethylene Glycols; D009153:Mutagens; C034096:ethoxyacetic acid; C005219:methyl cellosolve; D000079:Acetaldehyde; C021296:2-ethoxyethanol; D019342:Acetic Acid