title: Intracranial tuberculosis in The Netherlands: four paediatric cases.
abstract: Since 1987 a resurgence of tuberculosis is occurring in the Netherlands in analogy to the situation in other industralised countries. So far this has not been associated with an increased incidence of tuberculous meningitis, which is still a rare complication of the disease. Four cases of intracranial tuberculosis were recently diagnosed in our hospital. All children were from middle-class Dutch families with no identified risk for tuberculosis. An extensive contact identification search could identify a contact in two patients. Two children were in an advanced stage of disease before diagnosis. Skin tests were repeatedly negative in all cases which delayed treatment in two cases for almost 2 weeks. One patient developing a cerebral tuberculous focus during therapy responded well to a second course of corticosteroids. Three children developed severe neurological sequelae.
  
  
  CONCLUSIONS
  This report illustrates that suspicion of intracranial tuberculosis is warranted in the case of an ill-defined inflammatory neurological syndrome.
authors.affiliation: Department of Paediatrics, Beatrix Children's Hospital, University Hospital Groningen, The Netherlands.
authors.forename: J B
authors.initials: JB
authors.lastname: van Woensel
authors.forename: C G
authors.initials: CG
authors.lastname: Hoogeveen
authors.forename: J H
authors.initials: JH
authors.lastname: Begeer
authors.forename: G
authors.initials: G
authors.lastname: Visser
authors.forename: J L
authors.initials: JL
authors.lastname: Kimpen
mesh_terms: D000995:Antitubercular Agents / Q000627:therapeutic use; D001921:Brain / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D016358:Contact Tracing; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007223:Infant; D008279:Magnetic Resonance Imaging; D008297:Male; D009426:Netherlands; D009460:Neurologic Examination; D011239:Prednisolone / Q000627:therapeutic use; D014390:Tuberculosis, Meningeal / Q000145:classification / Q000175:diagnosis* / Q000188:drug therapy / Q000635:transmission
chemical_list: D000995:Antitubercular Agents; D011239:Prednisolone