[The toxic effect of serotonin in direct and mediated actions on rat embryos].
Embryotoxic effect of serotonin in direct (intra-amniotic administration) and indirect (subcutaneous administration) treatment was studied. In both cases serotonin causes embryo death and different abnormalities in development in small number of embryos. Mechanism of serotonin embryotoxic effect is under discussion.
Chebotar'
N A
NA
Konopistseva
L A
LA
Dorosev
N V
NV
Abdaladze
N S
NS
Puchkov
V F
VF
D000014:Abnormalities, Drug-Induced / Q000209:etiology / Q000473:pathology; D000650:Amnion; D000818:Animals; D003404:Creatinine / Q000008:administration & dosage / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004338:Drug Combinations; D020964:Embryo Loss / Q000139:chemically induced / Q000473:pathology; D004622:Embryo, Mammalian / Q000187:drug effects*; D005260:Female; D005865:Gestational Age; D007267:Injections; D007279:Injections, Subcutaneous; D011247:Pregnancy; D051381:Rats; D012701:Serotonin / Q000008:administration & dosage / Q000633:toxicity*
D004338:Drug Combinations; C014050:creatinine sulfate, serotonin drug combination; D012701:Serotonin; D003404:Creatinine