title: Junctional region of the myelin basic protein-specific T cell receptor beta chain in mice.
abstract: Evidence for the existence of both conserved and diverse amino acid sequences in the junctional regions of the myelin basic protein (MBP)-specific T cell receptors (TCR) in mice is presented. The junctional region of the Nac1-11 MBP peptide-specific, H-2u-restricted TCR beta-chains is characterized by the utilization of similar amino acid sequences. In contrast, diverse junctional sequences within the TCR beta-chains of the p89-101 MBP peptide and H-2s-restricted T cell clones are reported. These findings demonstrate that a limited heterogeneity of the MBP-specific T cell clones does exist. However, it may not be universal even in inbred mouse strains.
authors.affiliation: Department of Neurology, Thomas Jefferson University, Philadelphia, PA 19107-5083, USA.
authors.forename: B
authors.initials: B
authors.lastname: Kalman
authors.forename: H
authors.initials: H
authors.lastname: Alder
authors.forename: R L
authors.initials: RL
authors.lastname: Knobler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D051379:Mice; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000276:immunology*; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D004676:Myelin Basic Protein; D016693:Receptors, Antigen, T-Cell, alpha-beta