Diffusely discordant In-111 WBC/Tc-99m SC bone marrow uptake. A possible chemotherapeutic effect.
In-111 WBC scintigraphy in a woman with relapsed acute lymphoid leukemia demonstrated normal uptake of white blood cells by the liver and spleen, but virtually absent bone marrow activity. Tc-99m SC imaging confirmed normal marrow function and distribution. A bone marrow biopsy revealed mildly hypocellular, regenerating marrow without leukemic infiltration. The effects of systemic cytotoxic chemotherapy on marrow reticuloendothelial function may have been responsible for this discordant uptake.
Achong
D M
DM
Department of Radiology, New England Medical Center, Boston, Massachusetts, USA.
Oates
E
E
D001853:Bone Marrow / Q000000981:diagnostic imaging*; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007945:Leukemia, Lymphoid / Q000000981:diagnostic imaging*; D007962:Leukocytes; D008875:Middle Aged; D011877:Radionuclide Imaging; D013671:Technetium Tc 99m Sulfur Colloid
D007205:Indium Radioisotopes; D013671:Technetium Tc 99m Sulfur Colloid