title: [Inhibitory effect of SP on GABA-activated currents in freshly isolated rat DRG neurons].
abstract: The whole-cell patch-clamp technique was used to record GABA-activated currents in freshly isolated DRG neurons. It was found that application of SP (10(-7)-10(-5) mol/L) could induce concentration dependent inward currents in some cells (4/26), while no such current was detectable in the other neurons. However, preapplication of SP could inhibit the inward currents mediated by GABAA receptor (18/22). The inhibitory effect of SP was concentration dependent and reversible, and the desensitization of GABA-activated current could also be enhanced by SP.
authors.affiliation: Research Center of Experimental Medicine, Tongji Medical University, Wuhan.
authors.forename: X P
authors.initials: XP
authors.lastname: Wu
authors.forename: Z W
authors.initials: ZW
authors.lastname: Li
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Fan
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003864:Depression, Chemical; D004594:Electrophysiology; D005727:Ganglia, Spinal / Q000502:physiology*; D009474:Neurons / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D013373:Substance P / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
chemical_list: D013373:Substance P; D005680:gamma-Aminobutyric Acid