Control of signal transduction and morphogenesis by Ras.
The single Ras homologue (Ras1) of S. pombe regulates two distinct processes: (1) Signal transduction through a MAP kinase-like protein kinase cascade in response to mating pheromones. In this pathway Ras1 interacts with the protein kinase Byr2 and leads to its activation in conjunction with a signal from the receptor-coupled, heterotrimeric G protein. (2) Polarized cell growth both during the cell cycle and during directed cell extension towards a mating partner. Ras1 interacts with Ral1/Scd1, a putative guanine-nucleotide-exchange factor, which could activate Cdc42, Rho-like GTP-binding protein. Cdc42 may regulate the dynamics of the actin cytoskeleton.
Hughes
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CRC Centre for Cell and Molecular Biology, Chester Beatty Laboratories, London, UK.
D000595:Amino Acid Sequence; D004268:DNA-Binding Proteins; D005057:Eukaryotic Cells / Q000502:physiology; D005656:Fungal Proteins / Q000502:physiology*; D019204:GTP-Binding Proteins / Q000502:physiology*; D005800:Genes, Fungal; D011905:Genes, ras; D006160:Guanosine Triphosphate / Q000502:physiology; D036341:Intercellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D009024:Morphogenesis / Q000502:physiology*; D010455:Peptides / Q000502:physiology; D010675:Pheromones / Q000502:physiology; D010766:Phosphorylation; D011494:Protein Kinases / Q000502:physiology; D011499:Protein Processing, Post-Translational; D012441:Saccharomyces cerevisiae / Q000502:physiology; D029701:Saccharomyces cerevisiae Proteins; D012568:Schizosaccharomyces / Q000235:genetics / Q000502:physiology* / Q000648:ultrastructure; D029702:Schizosaccharomyces pombe Proteins; D015398:Signal Transduction / Q000502:physiology*; D013045:Species Specificity; D018631:ras Proteins
D004268:DNA-Binding Proteins; D005656:Fungal Proteins; D036341:Intercellular Signaling Peptides and Proteins; C089516:Mating Factor, S pombe; D010455:Peptides; D010675:Pheromones; D029701:Saccharomyces cerevisiae Proteins; D029702:Schizosaccharomyces pombe Proteins; C490320:mfm1 protein, S pombe; D006160:Guanosine Triphosphate; D011494:Protein Kinases; D019204:GTP-Binding Proteins; C489014:RAS1 protein, S cerevisiae; C492657:Ras1 protein, S pombe; D018631:ras Proteins