title: [Clinical significance of circulating soluble E-selectin (ELAM-1) in patients with cancers].
abstract: Cell adhesion mediated by E-selectin and its carbohydrate ligands, Le(a) and Le(x), plays an important role in cancer metastasis. We determined soluble E-selectin concentration in the sera of patients with cancers using double determinant sandwich assay. The results indicated that the patients with metastatic colon cancers had significantly higher serum E-selectin concentration than the patients having no metastatic lesion. The highest frequency of metastasis was obtained in Le(a) HIGH E-selectinHIGH patients (80%), while the frequency was quite low in Le(a) LOW E-selectinLOW patients (17%). Expression of E-selectin, as well as its carbohydrate ligands, is suggested to be a risk factor for the metastasis of epithelial cancers. Soluble E-selectin-carbohydrate complex was also detected in the sera of patients, and the frequency was especially high in Le(a) HIGH E-selectinHIGH patients.
authors.affiliation: Laboratory of Experimental Pathology, Aichi Cancer Center, Research Institute.
authors.forename: C
authors.initials: C
authors.lastname: Mitsuoka
authors.forename: R
authors.initials: R
authors.lastname: Kannagi
mesh_terms: D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D015815:Cell Adhesion Molecules / Q000097:blood*; D019040:E-Selectin; D006801:Humans; D009369:Neoplasms / Q000097:blood*
chemical_list: D015295:Antigens, Tumor-Associated, Carbohydrate; D015815:Cell Adhesion Molecules; D019040:E-Selectin