T-cell regulation of macrophage function.
Macrophage function has long been known to be controlled by activated T cells. As the cytokines that control macrophage activation are defined, it is becoming apparent that macrophage 'activation' is more subtle than previously appreciated. Moreover, recent work has shown the dependence of T-cell development on macrophages, from the costimulation of T cells by macrophage surface molecules such as the B7 family, to the modulation by monokines of T-cell phenotype and growth, including IL-1, IL-10, IL-12 and IL-15. Combinations of cytokines and costimulators have revealed some of the processes by which an apparently dichotomous T-cell response can regulate the subtle diversity of the immune response.
Doherty
T M
TM
Laboratory of Parasitic Diseases, NIAID, NIH, Bethesda, MD 20892, USA.
D002450:Cell Communication; D016207:Cytokines / Q000276:immunology; D006801:Humans; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology*; D015398:Signal Transduction; D013601:T-Lymphocytes / Q000276:immunology*
D016207:Cytokines