title: Relationship between staining by digital subtraction angiography and vascularity in breast cancer: analysis of the time-density curve and the results of staining for factor VIII-related antigen/von Willebrand factor.
abstract: We performed intravenous digital subtraction angiography (IV-DSA) in 31 patients with primary invasive breast cancer, and calculated the maximum density of tumor staining from the time-density curve obtained. Specimens resected from the same patients were stained for factor VIII-related antigen/von Willebrand factor (vWF), and the amount of microvessels was calculated by image processing. A significant correlation (correlation coefficient: 0.85) was found between the maximum density of tumor staining and the vascularity determined by staining for vWF, indicating that the maximum density indirectly reflects the vascularity in the tumor.
authors.affiliation: Department of Surgery, Tokyo Women's Medical College Daini Hospital, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Watanabe
authors.forename: S
authors.initials: S
authors.lastname: Haga
authors.forename: T
authors.initials: T
authors.lastname: Shimizu
authors.forename: H
authors.initials: H
authors.lastname: Imamura
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: J
authors.initials: J
authors.lastname: Kinoshita
authors.forename: T
authors.initials: T
authors.lastname: Kajiwara
authors.forename: M
authors.initials: M
authors.lastname: Fujibayashi
mesh_terms: D015901:Angiography, Digital Subtraction; D001943:Breast Neoplasms / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000276:immunology; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply* / Q000000981:diagnostic imaging / Q000276:immunology; D005260:Female; D006801:Humans; D008833:Microcirculation; D013194:Staining and Labeling; D014841:von Willebrand Factor / Q000032:analysis*
chemical_list: D014841:von Willebrand Factor