title: Application of a unique automated synthesis system for solution-phase peptide synthesis.
abstract: An automated synthesis system, which is suitable for repetitive syntheses using similar reaction procedures, was used to synthesize systematically a library of all possible dipeptides (25) and tripeptides (125) from 5 protected amino acids. The apparatus has also been applied to the automated synthesis of 10 fragment tripeptide derivatives that are constituents of the hormone PACAP-27. The measured molecular optical rotation values of the library of 125 tripeptides were found to correlate well with calculated values obtained by summation of the molecular optical rotation values for the constituent amino acids.
authors.affiliation: Molecular Chemistry Laboratory, Takeda Chemical Industries Ltd., Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sugawara
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Okamoto
authors.forename: C
authors.initials: C
authors.lastname: Kitada
authors.forename: M
authors.initials: M
authors.lastname: Fujino
mesh_terms: D000595:Amino Acid Sequence; D001331:Automation; D004151:Dipeptides / Q000138:chemical synthesis; D008969:Molecular Sequence Data; D009479:Neuropeptides / Q000138:chemical synthesis; D009842:Oligopeptides / Q000138:chemical synthesis; D010455:Peptides / Q000138:chemical synthesis*; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D011487:Protein Conformation; D012984:Software; D012996:Solutions
chemical_list: D004151:Dipeptides; D009479:Neuropeptides; D009842:Oligopeptides; D010455:Peptides; D051219:Pituitary Adenylate Cyclase-Activating Polypeptide; D012996:Solutions