[The participation of serotonin S2 receptors in realizing the effects of stress on ulcer formation in the gastric mucosa of inbred mice].
Significant interstrain differences in intensity and character of changes in gastric mucosa induced by affecting the serotoninergic system, were found. The main mechanism of stress-induced stomach ulceration was found to involve brain serotonin in central regulation of the stomach blood flow. Use of exogenic amine and its precursor corroborated the serotonin-dependent ulceration of the stomach in mice.
Koriakina
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D006916:5-Hydroxytryptophan / Q000494:pharmacology; D000818:Animals; D003404:Creatinine / Q000494:pharmacology; D003533:Cyproheptadine / Q000494:pharmacology; D004338:Drug Combinations; D005753:Gastric Mucosa / Q000187:drug effects / Q000503:physiopathology*; D005838:Genotype; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D012149:Restraint, Physical; D012701:Serotonin / Q000494:pharmacology; D013276:Stomach Ulcer / Q000209:etiology / Q000503:physiopathology*; D013315:Stress, Psychological / Q000150:complications / Q000503:physiopathology*; D013997:Time Factors
D004338:Drug Combinations; D011985:Receptors, Serotonin; C014050:creatinine sulfate, serotonin drug combination; D003533:Cyproheptadine; D012701:Serotonin; D003404:Creatinine; D006916:5-Hydroxytryptophan