Inhibition of insulin production by FK 506 is caused at the transcriptional level in pancreatic beta cell when FK BP-12 content is relatively high.
Tamura
K
K
Research Laboratories, Fujisawa Pharmaceutical Co, Ltd., Osaka, Japan.
Fujimura
T
T
Tsutsumi
T
T
Nakamura
K
K
Ogawa
T
T
Atumaru
C
C
Hirano
Y
Y
Ohara
K
K
Ohtsuka
K
K
Shimomura
K
K
D000818:Animals; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000032:analysis / Q000378:metabolism; D002352:Carrier Proteins / Q000032:analysis / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000032:analysis / Q000378:metabolism*; D015870:Gene Expression / Q000187:drug effects*; D006360:Heat-Shock Proteins / Q000032:analysis / Q000378:metabolism*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007328:Insulin / Q000096:biosynthesis*; D007515:Islets of Langerhans / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D007700:Kinetics; D008297:Male; D015345:Oligonucleotide Probes; D010749:Phosphoprotein Phosphatases / Q000032:analysis / Q000378:metabolism; D012333:RNA, Messenger / Q000032:analysis / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D016559:Tacrolimus / Q000097:blood / Q000494:pharmacology*; D022021:Tacrolimus Binding Proteins; D013997:Time Factors; D014158:Transcription, Genetic / Q000187:drug effects*
D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D007328:Insulin; D015345:Oligonucleotide Probes; D012333:RNA, Messenger; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases; D022021:Tacrolimus Binding Proteins; D016559:Tacrolimus