[A case of Sjögren's syndrome with rheumatoid arthritis manifesting transverse myelitis with antineuronal antibody].
We report a sixty-year-old woman with transverse myelitis who had suffered from rheumatoid arthritis since age of 52. She was admitted to our department because of muscle weakness and painful tonic spasm in the bilateral lower extremities, sensory disturbance below the mamillary level and bladder disturbance. She had sicca symptoms. As a result of sialography, Sjögren's syndrome was diagnosed. Antineuronal antibody was found in the sera of the patient. She had no symptom of systemic vasculitis. Lupus anticoagulant and anticaldiolipin antibody were negative. The pathogenesis of transverse myelitis in rheumatic disease is still uncertain. Vasculitis and the immunological reaction of antineuronal antibody have been suggested as possible causes. This report suggests the influence of direct immunological reaction on the central nervous system.
Fujimoto
Y
Y
Department of Internal Medicine, Tokyo Metropolitan Bokuto Hospital.
Arai
S
S
Ishida
K
K
Yokota
T
T
Yaginuma
M
M
Murase
H
H
D001172:Arthritis, Rheumatoid / Q000150:complications*; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009188:Myelitis, Transverse / Q000209:etiology* / Q000276:immunology; D009474:Neurons / Q000276:immunology; D012859:Sjogren's Syndrome / Q000150:complications*
D001323:Autoantibodies