title: Comparison of rufloxacin and norfloxacin effects on faecal flora.
abstract: The suppression of faecal Escherichia coli by quinolones was studied in a randomized cross-over phase I trial with single oral doses of 400 mg rufloxacin or norfloxacin. Both drugs caused > 70% decontamination in a similar number of subjects in the 72 h post-dose period (83% vs 100% respectively), but suppression of E. coli at 168 h was significantly (P < 0.05) higher after rufloxacin (83.3 vs 40%).
authors.affiliation: Microbiology Department, Hospital Clinic i Provincial, Barcelona, Spain.
authors.forename: F
authors.initials: F
authors.lastname: Marco
authors.forename: M J
authors.initials: MJ
authors.lastname: Giménez
authors.forename: M T
authors.initials: MT
authors.lastname: Jiménez de Anta
authors.forename: M A
authors.initials: MA
authors.lastname: Marcos
authors.forename: P
authors.initials: P
authors.lastname: Salvá
authors.forename: L
authors.initials: L
authors.lastname: Aguilar
mesh_terms: D000328:Adult; D000890:Anti-Infective Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D001441:Bacteroides fragilis / Q000187:drug effects; D015169:Colony Count, Microbial; D004926:Escherichia coli / Q000187:drug effects; D005243:Feces / Q000737:chemistry / Q000382:microbiology*; D024841:Fluoroquinolones; D006801:Humans; D008297:Male; D009643:Norfloxacin / Q000493:pharmacokinetics / Q000494:pharmacology*; D015363:Quinolones / Q000493:pharmacokinetics / Q000494:pharmacology*
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D015363:Quinolones; D009643:Norfloxacin; C060328:rufloxacin