Ferrous ions detected in iron-overloaded cord blood plasma from preterm and term babies: implications for oxidative stress.
Redox active iron chelatable to bleomycin is often present in the plasma of cord blood samples taken from preterm and term babies. The low caeruloplasmin and high ascorbate levels in plasma at birth may allow this iron to exist in the reduced ferrous state. In support of this postulate thirteen cord blood samples showing the presence of low molecular mass iron were able to degrade DNA in the presence of bleomycin and plasma.
Berger
H M
HM
Department of Pediatrics, University of Leiden, The Netherlands.
Mumby
S
S
Gutteridge
J M
JM
D001761:Bleomycin / Q000737:chemistry; D004247:DNA / Q000737:chemistry; D005260:Female; D005296:Ferrous Compounds / Q000097:blood*; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn / Q000097:blood*; D007234:Infant, Premature / Q000097:blood*; D007501:Iron / Q000097:blood*; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress
D005296:Ferrous Compounds; D001761:Bleomycin; D004247:DNA; D007501:Iron