title: Subregional mapping of the human gonadotropin-releasing hormone receptor (GnRH-R) gene to 4q between the markers D4S392 and D4S409.
abstract: We have isolated nine yeast artificial chromosomes (YACs) containing the gene that encodes the human gonadotropin-releasing hormone receptor (GnRH-R) gene by screening the YAC library of the Centre d'Etude du Polymorphisme Humain (Hôpital Saint-Louis, Paris, France) by the use of the polymerase chain reaction. We defined the location of the GnRH-R gene relative to 4q microsatellite markers D4S392 and D4S409. The genetic positions of these markers on chromosome 4 are 76 and 77 cM, respectively. This location was further established by chromosomal in situ hybridization.
authors.affiliation: Endocrinologie Cellulaire et Moléculaire de la Reproduction, URA CNRS 1449, Paris, France.
authors.forename: M L
authors.initials: ML
authors.lastname: Kottler
authors.forename: F
authors.initials: F
authors.lastname: Lorenzo
authors.forename: F
authors.initials: F
authors.lastname: Bergametti
authors.forename: P
authors.initials: P
authors.lastname: Commerçon
authors.forename: C
authors.initials: C
authors.lastname: Souchier
authors.forename: R
authors.initials: R
authors.lastname: Counis
mesh_terms: D001483:Base Sequence; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D005819:Genetic Markers; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008969:Molecular Sequence Data; D011966:Receptors, LHRH / Q000235:genetics*
chemical_list: D005819:Genetic Markers; D011966:Receptors, LHRH