Life and death during lymphocyte development and function: evidence for two distinct killing mechanisms.
During their development and after their functional activation most lymphocytes die, either because they fail to receive a survival signal or because they are actively killed. Recent experiments on Bcl-2 and Fas/Apo-1 have provided evidence that these two death processes are subject to distinct genetic control.
Strasser
A
A
Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia.
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D002470:Cell Survival / Q000276:immunology*; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor / Q000235:genetics*
D011518:Proto-Oncogene Proteins; D019253:Proto-Oncogene Proteins c-bcl-2; D019014:fas Receptor