[A preliminary study on the inhibitory action of target-primaqine on the exoerythrocytic forms of Plasmodium yoelii yoelii].
Target-primaquine (TPQ)--the primaquine entrapped by galactosylneoglycoalbumin (G-NGA), was given intravenously (iv) to Wistar rats 2 h after sporozoite inoculation. The sporozoite viability (SPV) of TPQ 20 mg/kg group was revealed to be 1.2% 42 h after inoculation, which showed a decline of about 6% as compared to the control; besides, degeneration or retardation of development was present in 90% of EEF. In TPQ 10 mg/kg and PQ 20 mg/kg groups, the SPV were 2.8% and 5.0%, respectively, showing drops by 15% and 26% as compared with that of the control. Degeneration or retardation in development was also visible in about half of the EEF. In mice which were treated iv with TPQ 10 mg/kg or PQ 20 mg/kg 2 h after sporozoite inoculation, the prepatent periods were delayed markedly as compared with that of the control. Parasitemia did not appear in 2 mice in 10 mg/kg TPQ group further indicated the effectiveness of the drug. The results suggest that the anti-EEF effect of TPQ is apparently more promising than that of PQ.
Song
J
J
Department of Parasitology, Third Military Medical University, Chongqing.
Wang
X
X
Huang
F
F
Feng
C
C
Zhang
Z
Z
Huo
Y
Y
Pang
Q
Q
D000418:Albumins; D000818:Animals; D000962:Antimalarials / Q000008:administration & dosage* / Q000494:pharmacology; D004337:Drug Carriers; D016503:Drug Delivery Systems; D005260:Female; D008099:Liver / Q000469:parasitology*; D008288:Malaria / Q000188:drug therapy; D008297:Male; D051379:Mice; D010967:Plasmodium yoelii / Q000187:drug effects*; D011319:Primaquine / Q000008:administration & dosage* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D000418:Albumins; D000962:Antimalarials; D004337:Drug Carriers; C064861:galactosyl-neoglycoalbumin; D011319:Primaquine