[Conformational analysis of peptide antagonists in the design of pseudopeptide and non-peptide antagonists].
The comparative conformational analysis of four Substance P antagonists (NK1-) having different chemical structures allowed to formulate an hypothesis for a peptidic NK1 pharmacophore. The salient features of this pharmacophore (three aromatic groups and two carbonyl functions) belong to a beta-turn conformation. Thus, this kind of conformation might be the basis for the design of newer pseudo-peptidic and non-peptidic NK1 antagonists.
Goldstein
S
S
UCB, S.A. Secteur Pharma Drug Discovery, Chemin du Foriest, Belgique.
Neuwels
M
M
Lassoie
M A
MA
Houssin
R
R
Caumont
K
K
Differding
E
E
Henichart
J P
JP
D000595:Amino Acid Sequence; D008969:Molecular Sequence Data; D064729:Neurokinin-1 Receptor Antagonists; D010455:Peptides / Q000037:antagonists & inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D011487:Protein Conformation; D013373:Substance P / Q000037:antagonists & inhibitors*
D064729:Neurokinin-1 Receptor Antagonists; D010455:Peptides; D013373:Substance P