title: Primary cutaneous meningioma on the scalp: report of two siblings.
abstract: Primary cutaneous meningioma (PCM) is a rare tumor whose pathogenesis is quite obscure. We reported PCMs occurring on almost the same occipital region of two siblings studied by histology, immunohistochemistry, and electron microscopy. Both lesions were attached to duras, but extracranial. One lesion was histologically diagnosed as meningothelial meningioma; its tumor cells showed electron microscopically interdigitating cytoplasmic processes with junctional complexes. The other was interpreted as fibroblastic meningioma; its tumor cells were arranged linearly in a stepping-stone arrangement and had small dense bodies in the cytoplasm. The tumor cells stained positively with anti-vimentin antibody. Both lesions had adenomatous hyperplasia of the eccrine glands. Although the histologic and electron microscopic features of these two lesions slightly differed from each other, their pathogenesis was essentially considered to be acoelic or rudimentary meningocele.
authors.affiliation: Department of Dermatology, Tsuyama Central Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Miyamoto
authors.forename: M
authors.initials: M
authors.lastname: Mihara
authors.forename: Y
authors.initials: Y
authors.lastname: Hagari
authors.forename: S
authors.initials: S
authors.lastname: Shimao
mesh_terms: D000293:Adolescent; D003593:Cytoplasm / Q000648:ultrastructure; D004388:Dura Mater / Q000473:pathology; D004439:Eccrine Glands / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007150:Immunohistochemistry; D008297:Male; D008579:Meningioma / Q000235:genetics*; D008588:Meningocele / Q000473:pathology; D008854:Microscopy, Electron; D012535:Scalp / Q000473:pathology*; D012878:Skin Neoplasms / Q000235:genetics*; D014746:Vimentin / Q000032:analysis
chemical_list: D014746:Vimentin