Crystal structures of B-form DNA-RNA chimers complexed with distamycin.
Two DNA-RNA chimers, complexed with DNA minor groove binding drugs, have been observed to adopt the B-form conformation for the first time. Thus, the RNA duplex may assume the B-DNA conformation when interacting with drugs, peptides or proteins.
Chen
X
X
Ramakrishnan
B
B
Sundaralingam
M
M
D000998:Antiviral Agents; D003461:Crystallography; D004247:DNA / Q000737:chemistry* / Q000378:metabolism; D004214:Distamycins / Q000737:chemistry* / Q000378:metabolism; D009690:Nucleic Acid Conformation; D012313:RNA / Q000737:chemistry* / Q000378:metabolism
D000998:Antiviral Agents; D004214:Distamycins; D012313:RNA; C030000:stallimycin; D004247:DNA