title: Positron emission tomography with [11C]deuterium-deprenyl in temporal lobe epilepsy.
abstract: We performed positron emission tomography (PET) with [11C]deuterium-deprenyl in 9 patients with temporal lobe epilepsy (TLE) undergoing evaluation for possible epilepsy surgery. Seven patients had unilateral and 2 had bilateral mesiotemporal epileptic foci based on the preoperative investigation including ictal EEG discharges and PET with 2-[18F]fluoro-2-deoxyglucose (FDG). Deprenyl is an irreversible inhibitor of monoamine oxidase type B (MAO-B) with a very high affinity for the enzyme. In the brain, MAO-B is preferentially located in astrocytes, and a previous in vitro study showed increased binding of the ligand in sclerotic hippocampi. Dynamically acquired N-[methyl-11C]-a,a-di-deutero-L-deprenyl distribution in PET images were analyzed graphically, and the focus regions were assessed visually on the PET images. In addition, the accumulation rate and distribution volume of the tracer relative to the cerebellar cortex were measured in standardized homologous temporal regions by semiquantitative methods. Uptake of [11C]deuterium-deprenyl was significantly increased in the epileptogenic temporal lobes, both apparently and semiquantitatively. By calculating mean interlobar ratios, we identified the temporal lobe containing the epileptic focus in six unilateral cases. One case was ambiguous but was not falsely localized. The two bilateral cases were correctly identified as such. Our results suggest that PET with [11C]deuterium-deprenyl might be a useful method for identification of epileptogenic temporal lobes.
authors.affiliation: Department of Neurology, University Hospital, Uppsala, Sweden.
authors.forename: E
authors.initials: E
authors.lastname: Kumlien
authors.forename: M
authors.initials: M
authors.lastname: Bergström
authors.forename: A
authors.initials: A
authors.lastname: Lilja
authors.forename: J
authors.initials: J
authors.lastname: Andersson
authors.forename: V
authors.initials: V
authors.lastname: Szekeres
authors.forename: C E
authors.initials: CE
authors.lastname: Westerberg
authors.forename: G
authors.initials: G
authors.lastname: Westerberg
authors.forename: G
authors.initials: G
authors.lastname: Antoni
authors.forename: B
authors.initials: B
authors.lastname: Långström
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000818:Animals; D002525:Cerebellar Cortex / Q000378:metabolism / Q000503:physiopathology; D003903:Deuterium / Q000378:metabolism; D004569:Electroencephalography; D004833:Epilepsy, Temporal Lobe / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007700:Kinetics; D008024:Ligands; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008954:Models, Biological; D008996:Monoamine Oxidase Inhibitors / Q000378:metabolism; D012642:Selegiline / Q000378:metabolism; D013702:Temporal Lobe / Q000378:metabolism / Q000503:physiopathology; D014055:Tomography, Emission-Computed
chemical_list: D008024:Ligands; D008996:Monoamine Oxidase Inhibitors; D012642:Selegiline; D003903:Deuterium