title: Soluble T-cell products antigenically related to T-cell receptors.
abstract: Human peripheral blood mononuclear cells (PBMC) cultured with or without concanavalin A (Con A) secrete soluble TCR alpha and TCR beta chains. Soluble TCR-like products of three different relative molecular masses--185,000 (Mr 185 kDa), 152 and 42 kDa--which are antigenically similar to those on T lymphocytes have been found in sera from healthy adult donors. These findings suggest that soluble TCRs, antigenically similar to cell surface TCRs, are secreted from T lymphocytes.
authors.affiliation: Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ishizaka
authors.forename: T
authors.initials: T
authors.lastname: Tsujii
mesh_terms: D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D000939:Epitopes; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D010446:Peptide Fragments / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D012995:Solubility; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000939:Epitopes; D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell; D003208:Concanavalin A