Cytotoxicity of captafol in mammalian cells.
The cytotoxicity of captafol, a phthalimide-derived fungicide, was evaluated in IB-RS-2 cells. Captafol at 0.12-1.0 microgram/ml blocks the cell multiplication. This effect is concentration-dependent, only partially reversible and the degree of inhibition increases with time. The synthesis of DNA and RNA is inhibited in parallel by increasing concentrations of the chemical.
Rodrigues
M A
MA
Instituto Biológico, São Paulo, Brazil.
D'Angelo
M
M
D000818:Animals; D002215:Captan / Q000031:analogs & derivatives* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D053138:Cyclohexenes; D004261:DNA Replication / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D012313:RNA / Q000096:biosynthesis; D013552:Swine
D053138:Cyclohexenes; D012313:RNA; C001614:captafol; D002215:Captan