Adenovirus proteins that subvert host defenses.
Adenovirus encodes numerous products that counteract host defenses. A virus-encoded RNA, VA RNA1, prevents interferon-mediated shut-off of protein synthesis. Other protein products inhibit interferon-induced gene transcription, prevent cell killing by cytotoxic T cells or block apoptosis, and three sets of proteins independently block the cytolysis and inflammation induced by tumor necrosis factor. Studies of these factors are providing insights into viral pathogenesis.
Wold
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Dept of Molecular Microbiology and Immunology, St Louis University School of Medicine, MO 63104.
Hermiston
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Tollefson
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AE
D000258:Adenovirus Infections, Human / Q000276:immunology / Q000821:virology*; D000260:Adenoviruses, Human / Q000472:pathogenicity*; D000818:Animals; D017209:Apoptosis; D006801:Humans; D007113:Immunity, Innate / Q000276:immunology; D007372:Interferons / Q000037:antagonists & inhibitors / Q000235:genetics / Q000502:physiology; D013602:T-Lymphocytes, Cytotoxic / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors / Q000502:physiology; D014764:Viral Proteins / Q000096:biosynthesis / Q000235:genetics / Q000502:physiology*
D014409:Tumor Necrosis Factor-alpha; D014764:Viral Proteins; D007372:Interferons