Abnormalities in the fibrinolytic system of the vascular wall associated with atherosclerosis.
In summary, studies of the expression of fibrinolytic genes in the vessel wall suggest an active, ongoing proteolytic process, the activity of which is dependent on the relative amounts of tPA, uPA, and PAI-1 secreted and locally deposited. Disturbances in the balance of pro- and antifibrinolytic activity in atherosclerotic vessels have considerable potential for influencing both intra- and extravascular fibrinolytic events and may be causally related to the development of vascular disease.
Loskutoff
D J
DJ
Department of Vascular Biology, Scripps Research Institute, La Jolla, California 92037.
van Aken
B E
BE
Seiffert
D
D
D001158:Arteries / Q000503:physiopathology*; D001161:Arteriosclerosis / Q000503:physiopathology*; D002908:Chronic Disease; D005342:Fibrinolysis; D015870:Gene Expression; D006023:Glycoproteins / Q000502:physiology*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000201:enzymology; D017395:Plasminogen Activator Inhibitor 1 / Q000502:physiology*; D012333:RNA, Messenger / Q000235:genetics; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D019096:Vitronectin
D006023:Glycoproteins; D017395:Plasminogen Activator Inhibitor 1; D012333:RNA, Messenger; D019096:Vitronectin; D010959:Tissue Plasminogen Activator