title: Assessment of the sedative effect of medetomidine and determination of its optimal dose in thoroughbred horses.
abstract: The present study was carried out to assessing the sedative effect of medetomidine and determining its optimal dose in thoroughbred horses. Excessive ataxia after sedative treatment is dangerous for horses. Therefore three doses which may cause sufficient sedation with only mild ataxia were examined. Response to stimulation and the severity of ataxia suggested that 7.5 micrograms/kg BW, i.v., is optimal.
authors.affiliation: Japan Racing Association, Equine Research Institute, Tokyo.
authors.forename: S
authors.initials: S
authors.lastname: Hobo
authors.forename: H
authors.initials: H
authors.lastname: Aida
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001259:Ataxia / Q000139:chemically induced / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006736:Horses; D006993:Hypnotics and Sedatives / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D007093:Imidazoles / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D020926:Medetomidine; D013997:Time Factors
chemical_list: D006993:Hypnotics and Sedatives; D007093:Imidazoles; D020926:Medetomidine