CD44 is expressed throughout pre-implantation human embryo development.
The cell surface glycoprotein CD44 has been demonstrated in a variety of cell types in embryonic and adult tissues. We have established that CD44 is present on human oocytes, cumulus cells, early embryos and pre-hatched blastocysts by indirect immunofluorescence. We have also shown that CD44 is present on 8-11 week placental stroma cells, but not on the trophoblast. These findings demonstrate that CD44 is present throughout preimplantation development, and that down-regulation occurs on the embryonic surface after implantation.
Campbell
S
S
Department of Obstetrics and Gynaecology, University Hospital of South Manchester, UK.
Swann
H R
HR
Aplin
J D
JD
Seif
M W
MW
Kimber
S J
SJ
Elstein
M
M
D001755:Blastocyst / Q000378:metabolism* / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism*; D005314:Embryonic and Fetal Development; D005260:Female; D005455:Fluorescent Antibody Technique; D006801:Humans; D018960:Hyaluronan Receptors; D016023:Integrins / Q000378:metabolism; D010920:Placenta / Q000166:cytology / Q000378:metabolism; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D011956:Receptors, Cell Surface / Q000378:metabolism*; D016201:Receptors, Lymphocyte Homing / Q000378:metabolism*; D013194:Staining and Labeling; D017154:Stromal Cells / Q000378:metabolism; D014327:Trophoblasts / Q000378:metabolism
D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D016023:Integrins; D011956:Receptors, Cell Surface; D016201:Receptors, Lymphocyte Homing