title: Cell kinetic investigations in craniopharyngioma: preliminary results and considerations.
abstract: In vitro determination of 3H-thymidine labeling index (LI%) was carried out in craniopharyngiomas from 16 patients submitted to repeated surgical procedures. This study showed a poor correlation between LI% values and prognosis, but allowed to detect a high LI% variation in the same tumor investigated in serial different times. The spatial distribution of S-phase proliferative cells in squamous epithelium of cystic components suggests a rationale for intracavitary treatment of cystic and mixed craniopharyngioma and may help explain its success.
authors.affiliation: Department of Neurosurgery, Istituto Nazionale Neurologico C. Besta, Milano, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Broggi
authors.forename: A
authors.initials: A
authors.lastname: Franzini
authors.forename: L
authors.initials: L
authors.lastname: Cajola
authors.forename: F
authors.initials: F
authors.lastname: Pluchino
mesh_terms: D000293:Adolescent; D000328:Adult; D001761:Bleomycin / Q000008:administration & dosage; D002455:Cell Division / Q000187:drug effects / Q000502:physiology* / Q000528:radiation effects; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D003397:Craniopharyngioma / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery; D010902:Pituitary Gland / Q000187:drug effects / Q000473:pathology; D010910:Pituitary Irradiation; D010911:Pituitary Neoplasms / Q000188:drug therapy / Q000473:pathology* / Q000532:radiotherapy / Q000601:surgery; D018714:Radiotherapy, Adjuvant; D013238:Stereotaxic Techniques; D016896:Treatment Outcome
chemical_list: D001761:Bleomycin