Flare of arthritis with successful treatment of Felty's syndrome with granulocyte colony stimulating factor (GCSF).
A 58-year-old white male with Felty's syndrome was successfully treated with granulocyte colony stimulating factor (GCSF). GCSF can correct the granulocytopenia of Felty's syndrome and may be a beneficial therapeutic adjunct in patients who have serious infections associated with neutropenia. The patient developed a flare of arthritis concomitant with increased circulating neutrophils following GCSF therapy.
Hayat
S Q
SQ
Section of Rheumatology, Louisiana State University Medical Center, Shreveport 71130, USA.
Hearth-Holmes
M
M
Wolf
R E
RE
D000380:Agranulocytosis / Q000188:drug therapy / Q000209:etiology; D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000503:physiopathology; D005258:Felty Syndrome / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D011994:Recombinant Proteins / Q000627:therapeutic use
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor