title: Nitric oxide: biological mediator, modulator and effector.
abstract: Nitric oxide (NO) is synthesized from L-arginine by at least three isoforms of NO synthase enzyme (NOS). Once generated NO can interact with a number of molecular targets including haem proteins, enzymes, DNA, thiols, oxygen and superoxide. These reactions determine the profile of NO as a major biological mediator, modulator and effector molecule.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Alberta, Edmonton, Canada.
authors.forename: M W
authors.initials: MW
authors.lastname: Radomski
mesh_terms: D001681:Biological Assay; D004730:Endothelium, Vascular / Q000502:physiology; D006801:Humans; D007158:Immunologic Techniques; D009569:Nitric Oxide / Q000096:biosynthesis / Q000502:physiology* / Q000627:therapeutic use; D019001:Nitric Oxide Synthase / Q000145:classification / Q000378:metabolism; D015398:Signal Transduction
chemical_list: D009569:Nitric Oxide; D019001:Nitric Oxide Synthase