title: Disappearance of neutrophil fluctuations in a child with cyclic neutropenia by combination therapy of granulocyte colony-stimulating factor and high-dose immunoglobulin.
abstract: We report on a patient with cyclic neutropenia who was treated by granulocyte colony-stimulating factor (G-CSF) and high-dose immunoglobulin. The serial examination revealed cyclic fluctuations in the numbers of neutrophils, monocytes, platelets in peripheral blood, and in the serum G-CSF concentration. Bone marrow examination confirmed a cyclic fluctuation of both progenitor cells (CFU-GM) and CD10-positive B cells. The therapy of G-CSF followed by high-dose immunoglobulin achieved a disappearance of neutrophil oscillations. It suggested that the combination therapy of G-CSF with high-dose immunoglobulin might be effective for cyclic neutropenia.
authors.affiliation: Department of Pediatrics, Ehime University School of Medicine, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ishida
authors.forename: A
authors.initials: A
authors.lastname: Higaki
authors.forename: H
authors.initials: H
authors.lastname: Tauchi
authors.forename: Y
authors.initials: Y
authors.lastname: Yokota
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D016175:B-Lymphocyte Subsets / Q000378:metabolism; D004359:Drug Therapy, Combination; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use*; D007223:Infant; D009503:Neutropenia / Q000378:metabolism / Q000628:therapy*; D010507:Periodicity
chemical_list: D007136:Immunoglobulins; D016179:Granulocyte Colony-Stimulating Factor