Antibody-induced alterations of protein and nucleic acid metabolism during experimental thyroglobulin immunization.
The protein and nucleic acid contents of liver, spleen, muscle, kidney, and brain were studied in experimental autoimmune thyroiditis. Protein and ribonucleic acid levels showed a positive increase in the case of liver, spleen, and muscle on days 56 and 98 after immunization and on day 147 they reached control levels. Spleen deoxyribonucleic acid showed a significant increase on day 56, whereas the other days showed no change. Kidney and brain tissue revealed no change.
Lahiri
S
S
Department of Animal Physiology, Bose Institute, Calcutta, India.
Chakraborty
A
A
D000818:Animals; D001798:Blood Proteins / Q000378:metabolism; D004247:DNA / Q000096:biosynthesis; D007114:Immunization; D007457:Iodine Radioisotopes; D008297:Male; D009696:Nucleic Acids / Q000378:metabolism*; D011506:Proteins / Q000378:metabolism*; D012313:RNA / Q000096:biosynthesis; D011817:Rabbits; D013954:Thyroglobulin / Q000276:immunology*; D013967:Thyroiditis, Autoimmune / Q000378:metabolism*
D001798:Blood Proteins; D007457:Iodine Radioisotopes; D009696:Nucleic Acids; D011506:Proteins; D012313:RNA; D004247:DNA; D013954:Thyroglobulin