[Study of certain indicators of immunity upon infecting CBA/Calac line mice with Lassa virus].
Some immunity parameters (interferon, tumor necrosis factor, interleukin 1, etc.) were studied in CBA/Calac mice infected with Lassa virus. The results permit a hypothesis that a pathologic inflammatory reaction is responsible for the death of animals in experimental Lassa fever. One of the components of this reaction is endogenous shock involving a manifest production of immune response mediators, such as interferon, interleukin 1. and tumor necrosis factor.
Ignat'ev
G M
GM
Kaliberov
S A
SA
Pereboeva
L A
LA
Tverdokhlebov
A B
AB
Kras'ko
A G
AG
Godneva
A T
AT
D000818:Animals; D002460:Cell Line; D002522:Chlorocebus aethiops; D003602:Cytotoxicity, Immunologic; D006801:Humans; D007372:Interferons / Q000096:biosynthesis; D007375:Interleukin-1 / Q000096:biosynthesis; D007694:Killer Cells, Natural / Q000276:immunology; D007835:Lassa Fever / Q000276:immunology* / Q000378:metabolism; D008213:Lymphocyte Activation; D051379:Mice; D008808:Mice, Inbred CBA; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis; D014709:Vero Cells
D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha; D007372:Interferons