title: [Surface of cytochrome P-450 2B4: structure and function].
abstract: The review is devoted to the identification and structure of one of the cytochromes P450s-cytochrome P-450 2B4 derived from the rabbit liver endoplasmic reticulum. A critical review is made of the data on this enzyme membrane topology, its active site's structure and localization of its membrane and water-exposed regions. The paper is based on the data available in the literature and the authors' own findings. Various experimental and calculating methods used to identify the topography of cytochrome P450 are covered in the paper.
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Uvarov
authors.forename: E F
authors.initials: EF
authors.lastname: Kolesanova
authors.forename: E V
authors.initials: EV
authors.lastname: Apletalina
authors.forename: S A
authors.initials: SA
authors.lastname: Kozin
authors.forename: A I
authors.initials: AI
authors.lastname: Archakov
mesh_terms: D000595:Amino Acid Sequence; D001189:Aryl Hydrocarbon Hydroxylases; D003577:Cytochrome P-450 Enzyme System / Q000737:chemistry / Q000276:immunology / Q000502:physiology; D000939:Epitopes; D006801:Humans; D008969:Molecular Sequence Data; D010446:Peptide Fragments; D013250:Steroid Hydroxylases / Q000737:chemistry / Q000276:immunology / Q000502:physiology; D013499:Surface Properties
chemical_list: D000939:Epitopes; D010446:Peptide Fragments; D003577:Cytochrome P-450 Enzyme System; D013250:Steroid Hydroxylases; D001189:Aryl Hydrocarbon Hydroxylases; C050356:steroid 15-alpha-hydroxylase