Osteoporosis in severe congenital neutropenia treated with granulocyte colony-stimulating factor.
Recombinant human granulocyte colony-stimulating factor (G-CSF) has substantially improved life expectancy for children with severe congenital neutropenia (SCN). Severe osteoporosis, reported in this population, may relate to the disease process, or be a therapeutic side-effect. This report details bone loss, quantitated absorptiometrically and histomorphometrically, in a child with SCN and vertebral collapse, and the positive response to anabolic steroid and bisphosphonate therapy.
Bishop
N J
NJ
Department of Paediatrics, Addenbrooke's Hospital, Cambridge.
Williams
D M
DM
Compston
J C
JC
Stirling
D M
DM
Prentice
A
A
D045930:Anabolic Agents / Q000627:therapeutic use; D002675:Child, Preschool; D004164:Diphosphonates / Q000627:therapeutic use; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D009503:Neutropenia / Q000151:congenital* / Q000628:therapy; D010024:Osteoporosis / Q000209:etiology*; D011994:Recombinant Proteins / Q000009:adverse effects
D045930:Anabolic Agents; D004164:Diphosphonates; D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor