Cytotoxic lymphocytes. Two ways to kill target cells.
Of the two pathways implicated in target-cell damage by cytotoxic lymphocytes, secretory granule exocytosis seems to dominate in anti-viral immunity whereas the Fas pathway may regulate immune responses.
Henkart
P A
PA
Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20814.
Sitkovsky
M V
MV
D000818:Animals; D000954:Antigens, Surface / Q000502:physiology*; D003594:Cytoplasmic Granules / Q000378:metabolism*; D003602:Cytotoxicity, Immunologic; D005089:Exocytosis; D006801:Humans; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology*; D019014:fas Receptor
D000954:Antigens, Surface; D019014:fas Receptor