Iloprost enhances survival of axial-pattern skin flaps in an ischemia-reperfusion model.
Iloprost, a stable prostacyclin analogue, significantly enhances the survival of an axial-pattern groin flap in rats after ischemia-reperfusion. Treated flaps showed viability over 90 percent of their area 7 days after an 8-hour ischemic episode, whereas the saline-treated controls were viable over only 20 percent of their area (p = 0.002). This effect was seen at a low (10 ng/kg) dosage, and no apparent side effects were noted.
Rajagopal
U
U
Department of Surgery, University of Texas Southwestern Medical Center at Dallas, USA.
Friedman
R M
RM
Robinson
J B
JB
Rohrich
R J
RJ
D000818:Animals; D016285:Iloprost / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000503:physiopathology*; D012867:Skin / Q000098:blood supply*; D013524:Surgical Flaps; D014022:Tissue Survival / Q000187:drug effects
D016285:Iloprost