title: Neoadjuvant hormonal therapy before radical prostatectomy decreases the number of positive surgical margins in stage T2 prostate cancer: interim results of a prospective randomized trial. The Belgian Uro-Oncological Study Group.
abstract: OBJECTIVE
  We investigated the effect of neoadjuvant treatment before radical prostatectomy for clinically localized prostate cancer.
  
  
  METHODS
  A total of 130 patients with stages T2b and T3 prostate cancer was randomized in a multicenter study: 62 underwent immediate radical prostatectomy and 65 received 560 mg. estramustine phosphate daily for 6 weeks preoperatively.
  
  
  RESULTS
  For clinical stage T2b tumors the neoadjuvant treatment resulted in a significant decrease in positive surgical margins compared to the nonpretreated group. This difference was not found for clinical stage T3 tumors. The impact on progression and survival still must be analyzed.
  
  
  CONCLUSIONS
  Neoadjuvant treatment can be beneficial for clinical stage T2 prostate cancer. Optimal treatment for stage T3 tumors remains controversial.
authors.affiliation: Department of Urology, Katholieke Universiteit Leuven, Belgium.
authors.forename: H
authors.initials: H
authors.lastname: Van Poppel
authors.forename: D
authors.initials: D
authors.lastname: De Ridder
authors.forename: A A
authors.initials: AA
authors.lastname: Elgamal
authors.forename: W
authors.initials: W
authors.lastname: Van de Voorde
authors.forename: P
authors.initials: P
authors.lastname: Werbrouck
authors.forename: K
authors.initials: K
authors.lastname: Ackaert
authors.forename: R
authors.initials: R
authors.lastname: Oyen
authors.forename: G
authors.initials: G
authors.lastname: Pittomvils
authors.forename: L
authors.initials: L
authors.lastname: Baert
mesh_terms: D000368:Aged; D017024:Chemotherapy, Adjuvant; D004961:Estramustine / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011300:Preoperative Care; D011446:Prospective Studies; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000097:blood / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery*
chemical_list: D004961:Estramustine; D017430:Prostate-Specific Antigen