title: Treatment of hyperthermia and dehydration with hypertonic saline in dextran.
abstract: Hyperthermia may be accompanied by dehydration with or without electrolyte loss. To determine the efficacy of hypertonic saline in dextran solution (HSD, 7.5% NaCl in 6% dextran 70) for the treatment of heat stroke, rats were deprived of water for 24 h (DE) or not (ND), and then they were heat-stressed, and 4 mL/kg of saline (SAL) or HSD was administered via jugular cannula at the end of heat stress (a core temperature of 42.3 degrees C). The following four groups of 10 rats (Wistar-Furth) were used: NDSAL, DESAL, NDHSD, and DEHSD. Four control groups not subjected to heat stress were also studied. Percent change in plasma volume (PV) from baseline was significantly decreased by DE vs. ND (-6.8 +/- 1.2 vs. +4.6 +/- 1.6%) and increased by HSD vs. SAL (+10.1 +/- 4.1 vs. -3.5 +/- 1.6%) administration. Rats that were DE had significantly higher heating rates and less water loss during heat than ND rats, but hydration status was not correlated to 24 h survival. HSD groups had significantly higher PV and survival rates than their corresponding SAL groups regardless of hydrational status.
authors.affiliation: United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760-5007, USA.
authors.forename: C B
authors.initials: CB
authors.lastname: Matthew
mesh_terms: D000818:Animals; D001810:Blood Volume; D003643:Death; D003681:Dehydration / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D003911:Dextrans; D005334:Fever / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D006400:Hematocrit; D006358:Hot Temperature; D008297:Male; D051381:Rats; D011920:Rats, Inbred WF; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D013997:Time Factors; D015431:Weight Loss
chemical_list: D003911:Dextrans; D012462:Saline Solution, Hypertonic