Reversible neutropenia during a cold: possible involvement of risperidone? A case report.
After 9 days of risperidone therapy (2-6 mg/day), a 24-year-old schizophrenic female patient developed a leucopenia with neutropenia < 1000/mm3. A few days after starting the neuroleptic treatment, she suffered from a cold, without fever. All immunological tests performed yielded negative results except for influenza B virus. The cessation of the risperidone therapy was followed within 48 h by a normalisation of the WBC differential count. Therefore, in the absence of a rechallenge with risperidone for ethical reasons, it cannot be excluded that risperidone represents at least a partial cause of the observed neutropenia.
Meylan
C
C
Département Universitaire de Psychiatrie Adulte (DUPA), Hôpital de Cery, Prilly-Lausanne, Switzerland.
Bondolfi
G
G
Aubert
A C
AC
Baumann
P
P
D000328:Adult; D014150:Antipsychotic Agents / Q000494:pharmacology; D003080:Cold Temperature; D005260:Female; D006801:Humans; D007251:Influenza, Human; D007555:Isoxazoles / Q000494:pharmacology*; D009503:Neutropenia / Q000378:metabolism*; D010880:Piperidines / Q000494:pharmacology*; D018967:Risperidone; D012559:Schizophrenia
D014150:Antipsychotic Agents; D007555:Isoxazoles; D010880:Piperidines; D018967:Risperidone