title: Rational design of synthetic heparin analogues with tailor-made coagulation factor inhibitory activity.
abstract: Computer modelling of the antithrombin III-heparin-thrombin complex inspired the synthesis of novel glycoconjugates, whose factor Xa and thrombin inhibitory activities can be adjusted in a rational way, leading to anticoagulants with unprecedented characteristics.
authors.forename: P D
authors.initials: PD
authors.lastname: Grootenhuis
authors.forename: P
authors.initials: P
authors.lastname: Westerduin
authors.forename: D
authors.initials: D
authors.lastname: Meuleman
authors.forename: M
authors.initials: M
authors.lastname: Petitou
authors.forename: C A
authors.initials: CA
authors.lastname: van Boeckel
mesh_terms: D000925:Anticoagulants / Q000737:chemistry* / Q000378:metabolism / Q000494:pharmacology; D000990:Antithrombin III / Q000737:chemistry; D002240:Carbohydrate Sequence; D015195:Drug Design; D065427:Factor Xa Inhibitors; D006493:Heparin / Q000031:analogs & derivatives* / Q000737:chemistry*; D008969:Molecular Sequence Data; D011134:Polysaccharides / Q000737:chemistry / Q000378:metabolism; D011487:Protein Conformation; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors / Q000378:metabolism
chemical_list: D000925:Anticoagulants; D065427:Factor Xa Inhibitors; D011134:Polysaccharides; D000990:Antithrombin III; D006493:Heparin; D013917:Thrombin