title: Increased intracellular glycerophosphoinositol and arachidonic acid are biochemical markers for lindane toxicity.
abstract: Lindane stimulates the release of both glycerophosphoinositol and arachidonic acid from phospholipids in rat renal proximal tubular cell cultures. When lindane was added to the culture medium, a correlation between the time-course profiles of glycerophosphoinositol and arachidonate release was found. This suggests a pathway in which phosphatidylinositol is not directly broken down by phospholipase C, but can instead be broken down to glycerophosphoinositol and arachidonic acid by phospholipase A enzymes. Therefore, a mechanism of action of lindane is through its effect on glycerophosphoinositol and arachidonic acid metabolism.
authors.affiliation: Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá de Henares, Madrid, Spain.
authors.forename: S
authors.initials: S
authors.lastname: Senar
authors.forename: J C
authors.initials: JC
authors.lastname: Puente
authors.forename: P
authors.initials: P
authors.lastname: López-Aparicio
authors.forename: M N
authors.initials: MN
authors.lastname: Recio
authors.forename: M A
authors.initials: MA
authors.lastname: Pérez-Albarsanz
mesh_terms: D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D015415:Biomarkers; D002478:Cells, Cultured; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D010716:Phosphatidylinositols / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism
chemical_list: D015415:Biomarkers; D010716:Phosphatidylinositols; D011963:Receptors, GABA-A; D016718:Arachidonic Acid; D001556:Hexachlorocyclohexane; D010741:Phospholipases A