title: [In vitro fertilization failures related to a sperm hyperactivation defect: indication for microinjection?].
abstract: Development of hyperactivated motility is considered as necessary for penetration through zona pellucida. In a study concerning 114 IVF attempts, we could not establish a significant correlation between fertilization rate and hyperactivation rate (HA). On the contrary, most fertilization failures (16/21) we found for HA values < 10%. 10 of such couples could benefit of ICSI for the next attempt: fertilization rates were strictly similar to the general rate observed for ICSI in our group (48%).
authors.affiliation: Hôpital Edouard Herriot, Lyon.
authors.forename: J F
authors.initials: JF
authors.lastname: Guérin
authors.forename: P
authors.initials: P
authors.lastname: Gallot-Lavallée
authors.forename: J
authors.initials: J
authors.lastname: Lornage
authors.forename: M C
authors.initials: MC
authors.lastname: Pinatel
authors.forename: H
authors.initials: H
authors.lastname: Lejeune
authors.forename: D
authors.initials: D
authors.lastname: Boulieu
authors.forename: V
authors.initials: V
authors.lastname: Bied
authors.forename: F
authors.initials: F
authors.lastname: Payan
mesh_terms: D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D008297:Male; D008845:Microinjections / Q000379:methods; D018579:Patient Selection; D011247:Pregnancy; D011256:Pregnancy Outcome; D013081:Sperm Motility; D013094:Spermatozoa / Q000002:abnormalities*; D017211:Treatment Failure