[Bleomycin-induced fibroblast proliferation is inhibited by IH764-3].
It reports that IH764-3 has both therapeutical and prophylactic effect on bleomycin-induced pulmonary fibrosis in rats and mice. The data presented indicate that IH764-3 is a potent inhibitor of the two important ways commonly thought to be the main causes of pulmonary fibrosis induced by bleomycin (BLM): 1) BLM stimulates the alveolar macrophages to secrete fibroblast growth factor (FGF); and 2) BLM increases the proliferation rate of the fibroblast directly. This demonstration of suppression of the stimulative effect of BLM on the fibroblast proliferation by IH764-3 provides direct evidence that IH764-3 could be a promising anti-fibrogenetic drug candidate.
Hua
G
G
Institute of Hematology, CAMS, Tianjin.
Cui
Y
Y
Liu
J
J
D000818:Animals; D001761:Bleomycin; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry; D002455:Cell Division / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005346:Fibroblast Growth Factors / Q000378:metabolism; D005347:Fibroblasts / Q000187:drug effects; D008297:Male; D051379:Mice; D011658:Pulmonary Fibrosis / Q000139:chemically induced / Q000473:pathology*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
D004365:Drugs, Chinese Herbal; C079053:IH 764-3; D001761:Bleomycin; D005346:Fibroblast Growth Factors