Adenovirus-mediated gene transfer for cystic fibrosis: Part A. Safety of dose and repeat administration in the nasal epithelium. Part B. Clinical efficacy in the maxillary sinus.
Welsh
M J
MJ
Howard Hughes Medical Institute, Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA.
Zabner
J
J
Graham
S M
SM
Smith
A E
AE
Moscicki
R
R
Wadsworth
S
S
D000260:Adenoviruses, Human / Q000235:genetics*; D002985:Clinical Protocols; D002986:Clinical Trials as Topic; D003550:Cystic Fibrosis / Q000628:therapy*; D019005:Cystic Fibrosis Transmembrane Conductance Regulator; D005260:Female; D018014:Gene Transfer Techniques / Q000009:adverse effects; D015316:Genetic Therapy / Q000009:adverse effects; D005822:Genetic Vectors / Q000235:genetics; D006801:Humans; D008297:Male; D008443:Maxillary Sinus; D008565:Membrane Proteins / Q000008:administration & dosage / Q000235:genetics* / Q000627:therapeutic use; D009297:Nasal Mucosa
C505032:CFTR protein, human; D008565:Membrane Proteins; D019005:Cystic Fibrosis Transmembrane Conductance Regulator