[Status of phytotherapeutic drugs in treatment of benign prostatic hyperplasia].
Phytotherapeutic preparations are still commonly used for the treatment of symptomatic benign prostate hyperplasia (BPH) in Germany; in recent years there has even been an increase in their use, so that sales now amount to more than DM 220 millions per year. The preparations most frequently used are extracts of Hypoxis rooperi, the roots of the stinging nettle, the fruits of the saw palmetto, pumpkin seeds and rye pollen. The suggested mechanisms of action have not been documented by scientific observation. This applies especially to the blocking effect on 5 alpha-reductase postulated with the doses used. Moreover, a critical analysis of the data available suggests that the effects of phytotherapy are no better than those of placebo treatment. Further studies are urgently needed, to compare the effects of phytotherapy with those of chemically defined drugs (alpha 1-receptor antagonists, 5 alpha-reductase blocker) that seem to have a beneficial influence on the pathomechanism underlying symptomatic BPH.
Dreikorn
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K
Urologische Klinik, Zentralkrankenhaus Sankt-Jürgen-Strasse, Bremen.
Schönhöfer
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PS
D058891:5-alpha Reductase Inhibitors; D002986:Clinical Trials as Topic; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D015990:Placebo Effect; D010936:Plant Extracts / Q000008:administration & dosage* / Q000009:adverse effects; D010946:Plants, Medicinal; D011470:Prostatic Hyperplasia / Q000188:drug therapy*; D016896:Treatment Outcome
D058891:5-alpha Reductase Inhibitors; D010936:Plant Extracts