Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation.
The factors that may cause antigen-presenting cells to alter the pattern of protein processing and presentation to autoreactive T cells, and thereby stimulate autoimmune disease, are currently under debate. In this article, Chris Elson and colleagues suggest that cytokines associated with T helper 1 (Th1) cells alter the processing of proteins and that this effect can be counteracted by Th2-associated cytokines.
Elson
C J
CJ
University of Bristol Dept of Pathology and Microbiology, UK.
Barker
R N
RN
Thompson
S J
SJ
Williams
N A
NA
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D001324:Autoantigens; D000939:Epitopes