Immediate relief of spontaneous coronary artery spasm by intracoronary infusion of an endothelium-dependent vasodilator, substance P.
This report describes a 45-year-old Japanese man who had episodes of anginal chest pain on effort. Coronary arteriography in the baseline state revealed subtotal occlusion in the mid-portion of the left anterior descending coronary artery. After intracoronary infusion of an endothelium-dependent vasodilator, substance P, the subtotal occlusion was immediately abolished. We concluded that endothelium-dependent vasodilation evoked with substance P was present at the site where coronary vasospasm occurred spontaneously in our case.
Numaguchi
K
K
Research Institute of Angiocardiology and Cardiovascular Clinic, Kyushu University, Faculty of Medicine, Fukuoka, Japan.
Egashira
K
K
Inou
T
T
Takeshita
A
A
D017023:Coronary Angiography; D003326:Coronary Circulation; D003329:Coronary Vasospasm / Q000000981:diagnostic imaging / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009569:Nitric Oxide / Q000008:administration & dosage / Q000627:therapeutic use*; D013373:Substance P / Q000008:administration & dosage / Q000627:therapeutic use*; D014665:Vasodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*
D014665:Vasodilator Agents; D009569:Nitric Oxide; D013373:Substance P