Influence of hepatitis C virus (HCV) genotypes on HCV recombinant immunoblot assay patterns.
Ninety-six patients with chronic hepatitis C were studied. A second-generation recombinant immunoblot assay detected anti-NS4 antibodies significantly more often in patients infected by hepatitis C virus genotype 1 than in patients infected by other types. By a third-generation recombinant immunoblot assay, the prevalences of the four antibodies measured did not differ according to the hepatitis C virus genotype.
Pawlotsky
J M
JM
Department of Bacteriology and Virology, Hôpital Henri Mondor, Université Paris XII, Créteil, France.
Roudot-Thoraval
F
F
Pellet
C
C
Aumont
P
P
Darthuy
F
F
Remire
J
J
Duval
J
J
Dhumeaux
D
D
D000956:Antigens, Viral; D004797:Enzyme-Linked Immunosorbent Assay; D005838:Genotype; D016174:Hepacivirus / Q000145:classification / Q000235:genetics* / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000097:blood*; D006526:Hepatitis C / Q000276:immunology / Q000821:virology; D018937:Hepatitis C Antibodies; D018936:Hepatitis C Antigens; D006521:Hepatitis, Chronic / Q000276:immunology / Q000821:virology; D006801:Humans; D015151:Immunoblotting / Q000379:methods*; D017361:Viral Nonstructural Proteins / Q000276:immunology; D014773:Virology / Q000379:methods*
D000956:Antigens, Viral; D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D018936:Hepatitis C Antigens; C093542:NS4 protein, hepatitis C virus; D017361:Viral Nonstructural Proteins