title: Low-dose iloprost infusion improves insulin action in aged healthy subjects and NIDDM patients.
abstract: OBJECTIVE
  To investigate the effect of iloprost infusion on insulin action.
  
  
  METHODS
  Thirteen healthy subjects and 13 non-insulin-dependent diabetes mellitus (NIDDM) patients matched for age (68.2 +/- 0.5 vs. 67.9 +/- 0.5 years, NS), gender ratio (7 men:6 women vs. 6 men:7 women), body weight, body fat distribution, arterial blood pressure, and plasma triglyceride levels (1.89 +/- 0.09 vs. 1.87 +/- 0.08 mmol/l, NS) were studied. In eight healthy subjects and eight NIDDM patients, we studied insulin action by euglycemic glucose clamp (insulin infusion rate 2 mU.kg-1.min-1) along with saline and iloprost delivery (0.7 ng.kg-1.min-1). In the other five subjects of each group, forearm blood flow and insulin-mediated glucose uptake during saline and iloprost infusion (0.7 ng.kg-1.min-1) were investigated.
  
  
  RESULTS
  Iloprost infusion improved insulin-stimulated whole-body glucose uptake and oxidative and nonoxidative glucose metabolism in both study groups. Forearm blood flow under basal conditions and with insulin infusion (2 mU.kg-1.min-1) did not show any significant difference from that during saline and iloprost infusion (0.7 ng.kg-1.min-1) in healthy subjects and diabetic patients.
  
  
  CONCLUSIONS
  Iloprost infusion improves insulin action in healthy subjects and NIDDM patients.
authors.affiliation: Department of Geriatric Medicine and Metabolic Diseases II, University of Naples, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Paolisso
authors.forename: G
authors.initials: G
authors.lastname: Di Maro
authors.forename: A
authors.initials: A
authors.lastname: D'Amore
authors.forename: N
authors.initials: N
authors.lastname: Passariello
authors.forename: A
authors.initials: A
authors.lastname: Gambardella
authors.forename: M
authors.initials: M
authors.lastname: Varricchio
authors.forename: F
authors.initials: F
authors.lastname: D'Onofrio
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D003971:Diastole / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D016285:Iloprost / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D007700:Kinetics; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply*; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects; D013599:Systole / Q000187:drug effects
chemical_list: D001786:Blood Glucose; D007328:Insulin; D016285:Iloprost