Predictive factors in the response to interferon therapy in chronic hepatitis C.
Factors predicting the efficacy of interferon therapy were statistically analyzed on 111 patients with chronic hepatitis C. Of the treated patients (total doses of interferon; 96-468 MU), 35 (31.5%) had a long-term remission. On multivariate analysis, hepatitis C virus genotype (p < 0.0001), histological diagnosis (p < 0.05), fibrosis score of histological activity index (p < 0.01) and source of infection (p < 0.05) were found useful for predicting the response to interferon therapy. Our findings suggest that the outcome of interferon therapy can be predicted to some degree from pretreatment data, and that a new therapeutic strategy is necessary for the group of patients who are predicted to be nonresponders.
Yoshioka
K
K
Third Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Higashi
Y
Y
Yamada
M
M
Aiyama
T
T
Takayanagi
M
M
Tanaka
K
K
Okumura
A
A
Iwata
K
K
Kakumu
S
S
D000328:Adult; D000704:Analysis of Variance; D001483:Base Sequence; D005260:Female; D005838:Genotype; D016174:Hepacivirus / Q000235:genetics; D006526:Hepatitis C / Q000473:pathology / Q000628:therapy* / Q000821:virology; D006521:Hepatitis, Chronic / Q000473:pathology / Q000628:therapy* / Q000821:virology; D006801:Humans; D007372:Interferons / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D011379:Prognosis; D012367:RNA, Viral / Q000032:analysis; D012189:Retrospective Studies; D016896:Treatment Outcome
D012367:RNA, Viral; D007372:Interferons