Interactions between reactive oxygen species and sulfhydryl groups of cysteine, acetylcysteine and glutathione.
Oxidative potencies of hydrogen peroxide, superoxide anions or hydroxyl radicals towards sulfhydryl groups of cysteine, acetylcysteine or glutathione were studied. Acetylcysteine was the least susceptible to oxidation by reactive oxygen species. The most vigorous oxidant of sulfhydryl groups was hydrogen peroxide.
Robak
J
J
Department of Pharmacology, Medical College, Jagiellonian University, Kraków, Poland.
Gryglewski
R J
RJ
D000111:Acetylcysteine / Q000737:chemistry*; D002374:Catalase / Q000737:chemistry; D003545:Cysteine / Q000737:chemistry*; D005978:Glutathione / Q000737:chemistry*; D006861:Hydrogen Peroxide / Q000737:chemistry; D017665:Hydroxyl Radical / Q000737:chemistry; D017382:Reactive Oxygen Species / Q000737:chemistry*; D013438:Sulfhydryl Compounds / Q000737:chemistry*; D013482:Superoxide Dismutase / Q000737:chemistry
D017382:Reactive Oxygen Species; D013438:Sulfhydryl Compounds; D017665:Hydroxyl Radical; D006861:Hydrogen Peroxide; D002374:Catalase; D013482:Superoxide Dismutase; D005978:Glutathione; D003545:Cysteine; D000111:Acetylcysteine