The acylation stimulating protein-adipsin system.
Considerable evidence indicates that obesity, and in particular abdominal obesity, is a risk factor for both heart disease and non-insulin dependent diabetes mellitus. In spite of this, little is known of the regulation of triacylglycerol synthesis in adipose tissue other than by insulin. Acylation stimulating protein (ASP), a human plasma protein, stimulates triacylglycerol synthesis in adipose tissue and is also produced by human adipocytes. ASP may play a physiological role in the regulation of efficiency of adipose tissue fat storage and affect clearance of triglycerides from plasma.
Cianflone
K
K
McGill Unit for the Prevention of Cardiovascular Disease, McGill University, Montreal, Quebec, Canada.
Maslowska
M
M
Sniderman
A
A
D016475:3T3 Cells; D017667:Adipocytes / Q000378:metabolism; D000273:Adipose Tissue / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D001798:Blood Proteins / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D015926:Complement C3a / Q000031:analogs & derivatives*; D011416:Complement Factor D; D005947:Glucose / Q000493:pharmacokinetics; D006801:Humans; D051379:Mice; D009765:Obesity / Q000378:metabolism / Q000503:physiopathology*; D012697:Serine Endopeptidases / Q000032:analysis / Q000378:metabolism / Q000502:physiology*; D014280:Triglycerides / Q000096:biosynthesis / Q000502:physiology
D001798:Blood Proteins; D014280:Triglycerides; C044541:complement C3a, des-Arg-(77)-; D015926:Complement C3a; D012697:Serine Endopeptidases; C493488:CFD protein, human; D011416:Complement Factor D; C493491:complement factor D, mouse; D005947:Glucose