title: High frequency of mutagen-induced chromatid exchanges at interstitial telomere-like DNA sequence blocks of Chinese hamster cells.
abstract: Interstitial telomere-like DNA sequence arrays of Chinese hamster Don cells were delineated by fluorescence in situ hybridization in quadriradial and triradial chromosome configurations induced by X-rays, mitomycin C and teniposide (VM-26). Around 40% of the scored exchanges involved a telomeric-like block of sequences at a rearrangement site. This frequency was independent of the DNA-damaging agent, and the result suggests a general recombinogenic capacity of interstitial telomere-like DNA sequence repeats that, at least in the case of the agents employed, seems not to be related to the initial mechanism of DNA damage.
authors.affiliation: Centro Oncológico de Galicia, La Coruña, Spain.
authors.forename: J L
authors.initials: JL
authors.lastname: Fernández
authors.forename: J
authors.initials: J
authors.lastname: Gosálvez
authors.forename: V
authors.initials: V
authors.lastname: Goyanes
mesh_terms: D000818:Animals; D002460:Cell Line; D006224:Cricetinae; D003412:Cricetulus; D004247:DNA / Q000187:drug effects* / Q000235:genetics; D004249:DNA Damage; D017404:In Situ Hybridization, Fluorescence; D009153:Mutagens / Q000633:toxicity*; D012854:Sister Chromatid Exchange; D016615:Telomere
chemical_list: D009153:Mutagens; D004247:DNA