title: Biologic response modifiers in chronic hepatitis C.
abstract: Biologic response modifiers include various colony-stimulating factors and interleukins such as granulocyte-macrophage colony-stimulating factor, granulocyte colony-stimulating factor, and interleukin-2. Their use as therapy has proven to be beneficial in the treatment of various diseases, and in preventing hematologic disorders. Their biologic effects and the rationale for their use in chronic viral hepatitis, alone or in combination with interferon-alpha, are reviewed with respect to the treatment of chronic hepatitis C.
authors.affiliation: Hepatology Unit, Fundación Jiménez Díaz, Madrid, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Carreño
authors.forename: J A
authors.initials: JA
authors.lastname: Quiroga
mesh_terms: D002908:Chronic Disease; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use; D006526:Hepatitis C / Q000628:therapy*; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use*; D007376:Interleukin-2 / Q000627:therapeutic use; D010865:Pilot Projects
chemical_list: D007155:Immunologic Factors; D007376:Interleukin-2; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor