title: Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer.
abstract: We have investigated the expression of platelet-derived endothelial-cell growth factor/thymidine phosphorylase (PD-ECGF/dThdPase) in human breast-cancer tissues by the immunocytochemical method using anti-PD-ECGF/dThdPase monoclonal antibody. Out of 100 invasive-ductal-carcinoma tissue samples, 39 (39%) were evaluated as PD-ECGF/dThdPase-positive. The expression of PD-ECGF/dThdPase was identified mainly in the cytoplasma of tumor cells. The expression of PD-ECGF/dThdPase was significantly associated with the microvessel density assessed by immunostaining to factor-VIII-related-antigen (p < 0.05). However, there was no correlation between expression of PD-ECGF/dThdPase and menopausal status, tumor size, axillary lymph-node metastases, hormone-receptor status, epidermal-growth-factor receptor, or erb-B-2-protein and p53-protein expression. We suggest that expression of PD-ECGF/dThdPase plays an important role in the promotion of angiogenesis in human breast cancer.
authors.affiliation: Department of Surgery, Tokyo Metropolitan Komagome Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Toi
authors.forename: S
authors.initials: S
authors.lastname: Hoshina
authors.forename: T
authors.initials: T
authors.lastname: Taniguchi
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Ishitsuka
authors.forename: T
authors.initials: T
authors.lastname: Tominaga
mesh_terms: D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000098:blood supply / Q000201:enzymology / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply / Q000201:enzymology / Q000378:metabolism*; D016009:Chi-Square Distribution; D016228:Endothelial Growth Factors / Q000378:metabolism*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D009389:Neovascularization, Pathologic / Q000201:enzymology / Q000378:metabolism*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D013939:Thymidine Phosphorylase / Q000096:biosynthesis*
chemical_list: D000911:Antibodies, Monoclonal; D016228:Endothelial Growth Factors; D010982:Platelet-Derived Growth Factor; D013939:Thymidine Phosphorylase