title: [Experimental and clinical study of shuanghuanglian aerosol in treating acute respiratory tract infection].
abstract: Two hundrde and two cases of acute respiratory tract infection (ARI) were treated with Shuanghuanglian (SHL) aerosol. In these cases, the majority of cases were virus infection and 64% of them was caused by the respiratory syncytial virus (RSV). The virostatic and bacteriostatic test were done in vitro by the cell culture method and it was shown that SHL could inhibit the RSV, para-influenza I-IV and 23 kinds of pathogenic bacteria such as Staphylococcus aureus etc. The bacteriostatic effect was positively correlated to the SHL concentration. Experimental study showed that SHL could enhance the NK cell activity, promote the production of alpha-interferon and raise the rate of lymphocyte transformation. The controlled observation on SHL preparation with various dosage-forms revealed that the SHL aerosol in treating early ARI showed better results than that of injections and oral liquor symptomatologically (P < 0.01). The effective rate was 96%.
authors.affiliation: Second Hospital, Harbin Medical University.
authors.forename: Y H
authors.initials: YH
authors.lastname: Wang
authors.forename: K J
authors.initials: KJ
authors.lastname: Xu
authors.forename: W S
authors.initials: WS
authors.lastname: Jiang
mesh_terms: D000208:Acute Disease; D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000368:Aged; D002648:Child; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018357:Respiratory Syncytial Virus Infections / Q000188:drug therapy*; D018113:Respiratory Syncytial Virus, Human; D012141:Respiratory Tract Infections / Q000188:drug therapy* / Q000821:virology
chemical_list: D000336:Aerosols; D004365:Drugs, Chinese Herbal