Immunomodulating effect of acridine tautomers on eukaryotic cells.
The immunomodulating effect of some new amino- and imino-acridine derivatives, were investigated on antibody dependent cellular cytotoxicity (ADCC) and induced-blast transformation of lymphocytes. In different concentrations (2.0 x 10(-6) M, 4.0 x 10(-8) M and 2.0 x 10(-5) M) the drugs produced a suppression of PHA and ConA induced cell proliferative response except in the case of 2b, 2d and 2g amino-acridines. The suppressive effects were dose dependent and exhibited a higher inhibitory level in the case of imino-acridines. Some drugs at low concentration exerted a little enhancing effect on ADCC reaction.
Petri
I B
IB
Blood Transfusion Centre, Albert Szent-Györgyi University Medical School, Szeged, Hungary.
Berek
I
I
Galy
A M
AM
Barbe
J
J
Berek
L
L
Molnár
J
J
D000166:Acridines / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic; D004306:Dose-Response Relationship, Immunologic; D005057:Eukaryotic Cells; D007536:Isomerism; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*
D000166:Acridines; D000276:Adjuvants, Immunologic