Renal toxicity of albumin and other lipoproteins.
Proteinuria may be an independent risk factor for nephrosclerosis. One potential mechanism has emerged with the finding that lipoproteins, including albumin, modulate the biology of mesangial cells and proximal tubular epithelial cells when internalized. Consequent alterations in renal-cell lipid metabolism may underlie some of these effects.
Schreiner
G F
GF
CV Therapeutics Inc., Palo Alto, California, USA.
D000418:Albumins / Q000633:toxicity*; D000818:Animals; D006801:Humans; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology; D008074:Lipoproteins / Q000633:toxicity*; D011507:Proteinuria / Q000139:chemically induced
D000418:Albumins; D008074:Lipoproteins