Self-activation of N-phosphoamino acids and N-phosphodipeptides in oligopeptide formation.
N-Phosphorylamino acids and N-phosphoryldipeptides can self-activate to give the oligopeptide. An intramolecular mixed anhydride intermediate might exist during the self-activating process. A peptide bond was formed from the N-terminus to the C-terminus by the '1 + n' mechanism, which was similar to the rRNA-peptide biosynthesis pathway.
Zhao
Y
Y
Department of Chemistry, Tsinghua University, Beijing, Peoples Republic of China.
Ju
Y
Y
Li
Y
Y
Wang
Q
Q
Yin
Y
Y
Tan
B
B
D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry*; D049148:Aminoacylation; D002384:Catalysis; D004151:Dipeptides / Q000737:chemistry*; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000138:chemical synthesis*; D010766:Phosphorylation
D000596:Amino Acids; D004151:Dipeptides; D009842:Oligopeptides