Colocalization of vasoactive intestinal polypeptide and nitric oxide in penis-innervating neurons in the major pelvic ganglion of the rat.
By using a combination of fluorescent retrograde labeling and double immunofluorescence histochemistry, the present study revealed in the rat that the vast majority of major pelvic ganglion neurons innervating penile erectile tissue contained both vasoactive intestinal polypeptide (VIP) and nitric oxide synthase. The result suggests that VIP and nitric oxide may exert a cooperative action in penile erection.
Ding
Y Q
YQ
Department of Morphological Brain Science, Faculty of Medicine, Kyoto University, Japan.
Takada
M
M
Kaneko
T
T
Mizuno
N
N
D000594:Amino Acid Oxidoreductases / Q000378:metabolism; D000818:Animals; D007001:Hypogastric Plexus / Q000166:cytology / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism*; D009569:Nitric Oxide / Q000378:metabolism*; D019001:Nitric Oxide Synthase; D010410:Penile Erection / Q000502:physiology; D010413:Penis / Q000294:innervation*; D051381:Rats; D017208:Rats, Wistar; D014660:Vasoactive Intestinal Peptide / Q000378:metabolism*
D009569:Nitric Oxide; D014660:Vasoactive Intestinal Peptide; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases