title: Family history and the risk of prostatic carcinoma in a high risk group of urological patients.
abstract: OBJECTIVE
  We examine the association of family history and prostatic carcinoma.
  
  
  METHODS
  A total of 2,968 consecutive patients referred for prostate cancer detection responded to a questionnaire and underwent transrectal ultrasound examination with or without biopsy.
  
  
  RESULTS
  Of the men 329 (11.1%) had a family history of prostate cancer. No differences were observed between groups with and without a family history with respect to mean patient age, serum prostate specific antigen level or biopsy rate. Prostate cancer was detected in 133 of 329 patients (40.4%) with a family history and 769 of 2,639 (29.1) with no family history (p < 0.001, odds ratio 1.7). No significant differences were observed between cancer patients with or without a family history with respect to mean Gleason score (6.0 versus 6.2), patient age at diagnosis (65.8 versus 66.7) and prostate specific antigen level (16.8 versus 17.1).
  
  
  CONCLUSIONS
  Patients with a family history of prostate cancer have a greater risk of the disease. In this select group of patients a positive family history was not associated with an earlier age at cancer diagnosis or a different histological grade of tumor.
authors.affiliation: Department of Surgery, McGill University, Montreal, Quebec, Canada.
authors.forename: A G
authors.initials: AG
authors.lastname: Aprikian
authors.forename: M
authors.initials: M
authors.lastname: Bazinet
authors.forename: M
authors.initials: M
authors.lastname: Plante
authors.forename: A
authors.initials: A
authors.lastname: Meshref
authors.forename: C
authors.initials: C
authors.lastname: Trudel
authors.forename: S
authors.initials: S
authors.lastname: Aronson
authors.forename: M
authors.initials: M
authors.lastname: Nachabe
authors.forename: F
authors.initials: F
authors.lastname: Péloquin
authors.forename: J
authors.initials: J
authors.lastname: Déssureault
authors.forename: S
authors.initials: S
authors.lastname: Narod
mesh_terms: D000368:Aged; D016001:Confidence Intervals; D006801:Humans; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000453:epidemiology* / Q000235:genetics*; D012307:Risk Factors
chemical_list: D017430:Prostate-Specific Antigen