title: Immunomodulating effect of acridine tautomers on eukaryotic cells.
abstract: The immunomodulating effect of some new amino- and imino-acridine derivatives, were investigated on antibody dependent cellular cytotoxicity (ADCC) and induced-blast transformation of lymphocytes. In different concentrations (2.0 x 10(-6) M, 4.0 x 10(-8) M and 2.0 x 10(-5) M) the drugs produced a suppression of PHA and ConA induced cell proliferative response except in the case of 2b, 2d and 2g amino-acridines. The suppressive effects were dose dependent and exhibited a higher inhibitory level in the case of imino-acridines. Some drugs at low concentration exerted a little enhancing effect on ADCC reaction.
authors.affiliation: Blood Transfusion Centre, Albert Szent-Györgyi University Medical School, Szeged, Hungary.
authors.forename: I B
authors.initials: IB
authors.lastname: Petri
authors.forename: I
authors.initials: I
authors.lastname: Berek
authors.forename: A M
authors.initials: AM
authors.lastname: Galy
authors.forename: J
authors.initials: J
authors.lastname: Barbe
authors.forename: L
authors.initials: L
authors.lastname: Berek
authors.forename: J
authors.initials: J
authors.lastname: Molnár
mesh_terms: D000166:Acridines / Q000494:pharmacology*; D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D003602:Cytotoxicity, Immunologic; D004306:Dose-Response Relationship, Immunologic; D005057:Eukaryotic Cells; D007536:Isomerism; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology*
chemical_list: D000166:Acridines; D000276:Adjuvants, Immunologic