Modulatory effects of calcitonin gene-related peptide and substance P on human cholinergic sweat secretion.
Immunoreactivity to various peptides has been demonstrated in nerve terminals around the sweat glands, suggesting a regulatory function for these peptides on sweating. The present study evaluated the calcitonin-gene related peptide and substance P related regulation of sweating in man. Both calcitonin-gene related peptide and substance P, when administered alone, failed to cause sweat secretion, whereas sweating induced by methacholine chloride alone was four times greater when administered with calcitonin-gene related peptide and suppressed by 70% when administered with substance P. The degree of calcitonin-gene related peptide dependent augmentation and substance P dependent suppression of the methacholine chloride induced sweating was dependent on the concentration of calcitonin-gene related peptide and substance P. These findings suggest that calcitonin-gene related peptide enhances cholinergic sweating and substance P inhibits it.
Kumazawa
K
K
Department of Internal Medicine, Aichi Medical University, Japan.
Sobue
G
G
Mitsuma
T
T
Ogawa
T
T
D000328:Adult; D001285:Atropine / Q000494:pharmacology; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology* / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000494:pharmacology*; D010275:Parasympathetic Nervous System / Q000502:physiology; D013373:Substance P / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000502:physiology; D013546:Sweating / Q000187:drug effects*
D016210:Methacholine Chloride; D013373:Substance P; D001285:Atropine; D015740:Calcitonin Gene-Related Peptide