title: Superovulation, IGFBP-1 and birth weight.
abstract: In this study, the effect of superovulation on the circulating levels of insulin-like growth factor binding protein-1 (IGFBP-1) has been investigated. IGFBP-1 levels were measured in singleton pregnancies achieved either naturally (n = 203) or following superovulation, in-vitro fertilisation and embryo transfer (IVF-ET) with either pituitary desensitisation with buserelin and superovulation with human menopausal gonadotrophin (b/hMG) followed by IVF-ET (n = 15) or with clomiphene citrate and hMG (CC/hMG) followed by IVF-ET (n = 15, 1st trimester only). The circulating levels of IGFBP-1 were similar in all three groups during the first trimester, and in both normal and b/hMG pregnancies in the second, but were significantly higher during the third trimester in b/hMG pregnancies than in normal pregnancies (P = 0.0002). The birth weights were significantly lower in the b/hMG group (P = 0.04), but not in the CC/hMG group compared with natural conceptions. Gestational age at delivery was similar in control and b/hMG pregnancies, but significantly reduced in CC/hMG pregnancies (P = 0.04). These data suggest that pregnancies achieved following superovulation with b/hMG are associated with elevated levels of IGFBP-1 during the third trimester of pregnancy and reduced birth weight.
authors.affiliation: Academic Department of Obstetrics and Gynaecology, Chelsea and Westminister Hospital, London, UK.
authors.forename: M R
authors.initials: MR
authors.lastname: Johnson
authors.forename: R
authors.initials: R
authors.lastname: Irvine
authors.forename: F
authors.initials: F
authors.lastname: Hills
authors.forename: V N
authors.initials: VN
authors.lastname: Bolton
authors.forename: A A
authors.initials: AA
authors.lastname: Abbas
authors.forename: A A
authors.initials: AA
authors.lastname: Brooks
authors.forename: A C
authors.initials: AC
authors.lastname: Allman
authors.forename: T
authors.initials: T
authors.lastname: Chard
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D000328:Adult; D001724:Birth Weight / Q000502:physiology*; D002352:Carrier Proteins / Q000097:blood* / Q000378:metabolism; D002996:Clomiphene / Q000494:pharmacology; D004717:Endometrium / Q000378:metabolism; D005260:Female; D005307:Fertilization in Vitro; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1; D008596:Menotropins / Q000494:pharmacology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third / Q000097:blood*; D013480:Superovulation / Q000097:blood / Q000187:drug effects / Q000502:physiology*
chemical_list: D002352:Carrier Proteins; D018970:Insulin-Like Growth Factor Binding Protein 1; D002996:Clomiphene; D008596:Menotropins