title: Longstanding proliferation of CD3 negative large granular lymphocytes preceding the development of high grade non-Hodgkin's lymphoma.
abstract: A patient with a persistent CD3 negative large granular lymphocyte (LGL) proliferation with immunophenotypic and functional characteristics of natural killer cells is described. The LGL proliferation persisted and six years after diagnosis the patient developed a high grade B cell non-Hodgkin's lymphoma. Molecular studies demonstrated clonal B cell populations in the peripheral blood, distinct from that identified in the lymphoma, both at presentation with non-Hodgkin's lymphoma and at complete remission following combination chemotherapy. It is postulated that T cell dysregulation associated with the CD3 negative LGL proliferation may have led to B cell dysfunction and loss of normal B cell control, with the subsequent development of a clonal B cell lymphoproliferative disorder.
authors.affiliation: Department of Haematology, Newcastle General Hospital, Newcastle upon Tyne.
authors.forename: S R
authors.initials: SR
authors.lastname: Smith
authors.forename: P G
authors.initials: PG
authors.lastname: Middleton
authors.forename: P J
authors.initials: PJ
authors.lastname: Birch
authors.forename: L
authors.initials: L
authors.lastname: Morgan
authors.forename: P W
authors.initials: PW
authors.lastname: Saunders
mesh_terms: D000328:Adult; D015139:Blotting, Southern; D017252:CD3 Complex / Q000097:blood*; D002471:Cell Transformation, Neoplastic / Q000276:immunology; D015326:Gene Rearrangement, B-Lymphocyte, Heavy Chain; D006801:Humans; D007694:Killer Cells, Natural / Q000473:pathology*; D008218:Lymphocytosis / Q000150:complications* / Q000276:immunology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000209:etiology*; D008228:Lymphoma, Non-Hodgkin / Q000209:etiology*; D008297:Male
chemical_list: D017252:CD3 Complex