Substance P binding in normal neonatal foreskin.
The distribution of binding sites for NTE-biotinyl-[Arg3]-substance P (SPB) was demonstrated in neonatal foreskin using a conjugate of streptavidin with horseradish peroxidase. The observed binding is reversible, and may be abrogated by either the non-peptide substance P receptor antagonist, CP-96,345, or by unlabelled substance P. The generalized epidermal distribution and focal dermal localization of SPB binding suggest that although NK-1 receptors are abundant in human neonatal foreskin, neuromodulatory mechanisms may play a significant role in epidermal physiology.
Arenberger
P
P
Department of Dermatovenereology, Charles University School of Medicine, Prague, Czech Republic.
Leder
R O
RO
Abraham
A
A
Chang
J K
JK
Farber
E M
EM
D001665:Binding Sites; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D008297:Male; D010413:Penis / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D013545:Sweat Glands / Q000378:metabolism
D013373:Substance P