6-(4-pyridinyl)-1H-1,2,3-triazolo[4,5-d]-pyrimidin-4(5H)-one: a structurally novel competitive AMPA receptor antagonist.
Subramanyam
C
C
Department of Medicinal Chemistry, Sanofi Winthrop Inc., Collegeville, Pennsylvania 19426.
Ault
B
B
Sawutz
D
D
Bacon
E R
ER
Singh
B
B
Pennock
P O
PO
Kelly
M D
MD
Kraynak
M
M
Krafte
D
D
Treasurywala
A
A
D006624:Hippocampus / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D011744:Pyrimidinones / Q000737:chemistry / Q000494:pharmacology*; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors*; D014230:Triazoles / Q000737:chemistry / Q000494:pharmacology*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000378:metabolism
C092097:6-(4-pyridinyl)-1H-1,2,3-triazolo(4,5-d)pyrimidin-4(5H)-one; D011744:Pyrimidinones; D018091:Receptors, AMPA; D014230:Triazoles; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid