Increased serum levels of ICAM-1, ELAM-1 and TNF-alpha in inflammatory disorders of the peripheral nervous system.
Endothelial intercellular adhesion molecule-1 (ICAM-1) and glycoprotein E-selectin (ELAM-1) allow the homing of leukocytes to inflammation sites. A circulating form of ICAM-1 markedly increases in inflammatory CNS disorders. In the present study, the serum levels of ICAM-1, ELAM-1 and tumor necrosis factor-alpha (TNF-alpha) were measured in patients with acute (AIDP) and chronic (CIDP) inflammatory demyelinating polyneuropathies and cryoglobulinemic neuropathy (CGN). Immunoenzymometric assays revealed increased sICAM-1 levels in some of these patients; furthermore, high titres of ELAM-1 and TNF-alpha were detected in two patients with AIDP and one patient with CGN. Our data extend previous observations on inflammatory PNS disorders by showing that, in addition to ICAM-1, ELAM-1 also represents a useful marker of endothelial activation and that, taken together, the two molecules may serve as an indicator of specific pathogenetic mechanisms.
Musso
A M
AM
Istituto di Neurologia, Università di Verona, Italy.
Zanusso
G L
GL
Bonazzi
M L
ML
Tomelleri
G
G
Bonetti
B
B
Moretto
G
G
Vio
M
M
Monaco
S
S
D000328:Adult; D000368:Aged; D015815:Cell Adhesion Molecules / Q000097:blood*; D003449:Cryoglobulinemia / Q000097:blood; D003711:Demyelinating Diseases / Q000097:blood; D019040:E-Selectin; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood*; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000097:blood; D009443:Neuritis / Q000097:blood*; D010523:Peripheral Nervous System Diseases / Q000097:blood*; D011115:Polyneuropathies / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D015815:Cell Adhesion Molecules; D019040:E-Selectin; D008562:Membrane Glycoproteins; D014409:Tumor Necrosis Factor-alpha; D018799:Intercellular Adhesion Molecule-1