title: Effects of treatment with buserelin on plasma concentrations of oestradiol and progesterone and cycle length in the cow.
abstract: Treatment of cows with 10 micrograms of the gonadotrophin releasing hormone (GnRH) analogue, Buserelin (Receptal; Hoechst) 12 days after mating results in a 12% improvement in conception rate (Drew & Peters, 1991). We have now investigated the endocrine effects and possible mechanism of action underlying this effect. Treatment of cyclic cows (n = 5) with Buserelin on days 11 and 13 did not affect cycle length or plasma concentration of progesterone, but did significantly (P < 0.05) reduce plasma oestradiol concentration from day 12-16. We conclude that the Buserelin treatment acts by causing a fall in plasma oestradiol which results in a reduction in the strength of the luteolytic drive, improving the chance of an embryo being able to prevent luteal regression.
authors.affiliation: Department of Physiology and Environmental Science, University of Nottingham Sutton, Bonington, Loughborough, UK.
authors.forename: G E
authors.initials: GE
authors.lastname: Mann
authors.forename: G E
authors.initials: GE
authors.lastname: Lamming
mesh_terms: D000818:Animals; D002064:Buserelin / Q000494:pharmacology*; D002417:Cattle / Q000097:blood* / Q000502:physiology; D004958:Estradiol / Q000097:blood*; D004971:Estrus / Q000187:drug effects*; D005260:Female; D005298:Fertility / Q000187:drug effects; D011374:Progesterone / Q000097:blood*
chemical_list: D011374:Progesterone; D004958:Estradiol; D002064:Buserelin