title: Histopathological features and p53 nuclear protein staining as predictors of survival and tumor recurrence in patients with transitional cell carcinoma of the renal pelvis.
abstract: OBJECTIVE
  We determine which histopathological features are predictive of recurrence and cause-specific survival in renal pelvic transitional cell carcinoma.
  
  
  METHODS
  Univariant and multivariant analysis was done on material from 67 patients.
  
  
  RESULTS
  Univariate and multivariate analysis identified lamina propria invasion, grade 3 tumors and capillary-lymphatic invasion as predictors of disease-specific survival. Multicentric disease was the sole independent predictor of recurrence. Multicentric disease and lamina propria invasion were independent predictors of recurrence-free survival. Also, p53 over-expression was not statistically associated with any of the studied prognostic factors.
  
  
  CONCLUSIONS
  Histopathological features remain the cornerstone of prognostic assessment for renal pelvic transitional cell carcinoma.
authors.affiliation: Department of Urology, University of Iowa College of Medicine, Iowa City, USA.
authors.forename: R B
authors.initials: RB
authors.lastname: Terrell
authors.forename: J C
authors.initials: JC
authors.lastname: Cheville
authors.forename: W A
authors.initials: WA
authors.lastname: See
authors.forename: M B
authors.initials: MB
authors.lastname: Cohen
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002295:Carcinoma, Transitional Cell / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics / Q000401:mortality / Q000473:pathology*; D007682:Kidney Pelvis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D011237:Predictive Value of Tests; D012189:Retrospective Studies; D013194:Staining and Labeling; D015996:Survival Rate; D016159:Tumor Suppressor Protein p53 / Q000032:analysis* / Q000096:biosynthesis
chemical_list: D016159:Tumor Suppressor Protein p53