title: [Assessment of dispersion++ of ventricular recovery in patients with chronic obstructive pulmonary disease].
abstract: Cardiac arrhythmias are common in patients with chronic obstructive pulmonary disease. Several factors may contribute to the development of arrhythmias in these patients including hypoxemia, hypercapnia, acid-base disturbances. The aim of the study was to assess QTc dispersion in patients with chronic obstructive pulmonary disease, who are at high risk of arrhythmias. Interlead QT variability as measured on the 12-lead electrocardiogram is not a technical artifact but probably reflects regional differences in ventricular repolarization. Increased dispersion of ventricular recovery time is believed to provide a substrate which supports serious ventricular arrhythmias. We showed that in patients with chronic obstructive pulmonary disease, free of underlying structural heart disease, the QTc dispersion is significant greater (p = 0.036) than in a control group, despite a similar value in mean QTc value. The data of the present study suggest that the determination of dispersion of repolarization times may be affected by metabolic changes occurring in patients with chronic obstructive pulmonary disease.
authors.affiliation: Cattedra di Cardiologia, Istituto Medico-Chirurgico di Cardiologia, Seconda Università degli Studi, Napoli.
authors.forename: B
authors.initials: B
authors.lastname: Sarubbi
authors.forename: V
authors.initials: V
authors.lastname: Ducceschi
authors.forename: V
authors.initials: V
authors.lastname: Esposito
authors.forename: I
authors.initials: I
authors.lastname: Meoli
authors.forename: E
authors.initials: E
authors.lastname: Grella
authors.forename: M
authors.initials: M
authors.lastname: Caputi
authors.forename: L
authors.initials: L
authors.lastname: Santangelo
authors.forename: A
authors.initials: A
authors.lastname: Iacono
mesh_terms: D000328:Adult; D000368:Aged; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000150:complications / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016276:Ventricular Function / Q000502:physiology*