title: [Aprotinin antiviral aerosol: study of the local irritating and allergenic action after inhalation].
abstract: The aerosol of aprotinin, a natural low molecular weight polypeptide (m.w. about 160 kD) inhibiting a wide range of serine proteases may be used as an antiviral drug. The animal studies showed that it had no local irritating action on the mucosa. A long-term use of aprotinin in the form of a fine aerosol practically induced no allergenic side effects. The results of the study indicative of the absence of the allergic complications made it possible to recommend the aprotinin inhalations as a safe means in the treatment and prophylaxis of viral infections of the respiratory tract.
authors.forename: O P
authors.initials: OP
authors.lastname: Zhirnov
authors.forename: A V
authors.initials: AV
authors.lastname: Ovcharenko
authors.forename: P B
authors.initials: PB
authors.lastname: Goliando
authors.forename: T P
authors.initials: TP
authors.lastname: Svinogeeva
authors.forename: G V
authors.initials: GV
authors.lastname: Dolgova
authors.forename: A V
authors.initials: AV
authors.lastname: Nikitin
mesh_terms: D000280:Administration, Inhalation; D000336:Aerosols; D000818:Animals; D000998:Antiviral Agents / Q000008:administration & dosage / Q000633:toxicity*; D007611:Aprotinin / Q000008:administration & dosage / Q000633:toxicity*; D004342:Drug Hypersensitivity; D006168:Guinea Pigs; D007509:Irritants / Q000008:administration & dosage / Q000633:toxicity; D011817:Rabbits; D012141:Respiratory Tract Infections / Q000188:drug therapy
chemical_list: D000336:Aerosols; D000998:Antiviral Agents; D007509:Irritants; D007611:Aprotinin