Distribution of dipropyl [35S]-sulphoxide in the rat.
Dipropyl [35S]-sulphoxide was administered by gavage (4.24 mmol/kg body weight) to adult male Wistar rats and the placement of radioactivity about the animal examined at 4, 8 and 12 hours post-dosing. Widespread and diffuse distribution throughout soft tissues was observed with the largest amounts of radioactivity being found within the liver (3.2% dose at 4 h) and kidney (1.3% dose at 4 h). Activity levels declined over the 12 hour experimental period. This distribution pattern is discussed and compared with results previously reported for dimethyl sulphoxide.
Nickson
R M
RM
Department of Pharmacology and Toxicology, Imperial College of Science, Technology and Medicine, St. Mary's Hospital Medical School, London, U.K.
Mitchell
S C
SC
D000818:Animals; D001345:Autoradiography; D001798:Blood Proteins / Q000378:metabolism; D008297:Male; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar; D013055:Spectrophotometry, Infrared; D013454:Sulfoxides / Q000097:blood / Q000493:pharmacokinetics*; D013462:Sulfur Radioisotopes; D014018:Tissue Distribution
D001798:Blood Proteins; D013454:Sulfoxides; D013462:Sulfur Radioisotopes; C077278:dipropyl sulfoxide