The contrasting effects of colony-stimulating factor-1 and epidermal growth factor on tooth eruption in the rat.
Both epidermal growth factor (EGF) and colony-stimulating factor-1 (CSF-1) have been shown to accelerate eruption of teeth in rodents. We compared the effects of neonatal injections of EGF (1 micrograms/g body weight) and CSF-1 (10(6) units) alone or together on the eruption of incisors and first molars. EGF accelerated the eruption of incisors with no significant effect on first molars. CSF-1, in contrast, accelerated molar eruption more than incisor eruption. CSF-1, but not EGF, increased the numbers of mononuclear cells in the dental follicle and osteoclasts on adjacent alveolar bone surfaces around the first molar and produced enhanced resorption of crypt surfaces as revealed by scanning electron microscopy. These data suggest that during eruption rodent incisors and molars may preferentially respond to different molecular regulators.
Cielinski
M J
MJ
Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655-0106, USA.
Jolie
M
M
Wise
G E
GE
Marks
S C
SC
D000539:Alveolar Process / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D000818:Animals; D000831:Animals, Newborn; D001862:Bone Resorption / Q000473:pathology / Q000503:physiopathology; D002452:Cell Count / Q000187:drug effects; D003795:Dental Sac / Q000166:cytology / Q000187:drug effects / Q000648:ultrastructure; D004338:Drug Combinations; D004815:Epidermal Growth Factor / Q000008:administration & dosage / Q000494:pharmacology*; D007180:Incisor / Q000187:drug effects; D007958:Leukocyte Count / Q000187:drug effects; D007963:Leukocytes, Mononuclear / Q000187:drug effects; D016173:Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000494:pharmacology*; D008855:Microscopy, Electron, Scanning; D008963:Molar / Q000187:drug effects; D010010:Osteoclasts / Q000166:cytology / Q000187:drug effects; D051381:Rats; D014078:Tooth Eruption / Q000187:drug effects*
D004338:Drug Combinations; D004815:Epidermal Growth Factor; D016173:Macrophage Colony-Stimulating Factor