Identification of a pharmacophore for nucleoside analog inhibitors directed at HIV-1 reverse transcriptase.
An 'active analog' approach to receptor mapping was used to identify a pharmacophore for a set of thymidine nucleoside analog inhibitors of HIV-1 reverse transcriptase. The preliminary results indicate that the O2, O4', and O5' atoms are capable of adopting a unique pharmacophoric pattern which may be the key to their recognition by reverse transcriptase.
Fisher
M A
MA
Department Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark 07103.
Yadav
P N
PN
Yadav
J
J
Kristol
D
D
Arnold
E
E
Modak
M J
MJ
D001665:Binding Sites; D003196:Computer Graphics; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology; D008958:Models, Molecular; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors; D013329:Structure-Activity Relationship; D013936:Thymidine
D009705:Nucleosides; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase; D013936:Thymidine