Elevated plasma levels of P-selectin (GMP-140/CD62P) in patients with Plasmodium falciparum malaria.
The plasma concentration of soluble P-selectin (GMP-140/CD62P/PADGEM), a selectin produced by activated platelets and endothelial cells, was quantitated in a group of adults and East African negro children presenting with either non-severe or severe (cerebral) malaria caused by Plasmodium falciparum. Sixty percent of adults with non-severe malaria had immunoreactive levels of P-selectin above 200 ng/ml (the maximum recorded for any normal healthy adult in the assay) and 86% of all African children with malaria had concentrations above normal irrespective of their clinical categorization, and most exceeded the maximum limits of the assay (> 640 ng/ml). There was no correlation between P-selectin levels and parasitemia. These results raise the possibility that elevated soluble P-selectin in malaria may have an important beneficial anti-inflammatory function.
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Department of Haematology, London Hospital Medical College, United Kingdom.
Theodoridou
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D000328:Adult; D015703:Antigens, CD / Q000097:blood / Q000502:physiology; D044383:Black People; D002675:Child, Preschool; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D007223:Infant; D016779:Malaria, Cerebral / Q000097:blood* / Q000503:physiopathology; D016778:Malaria, Falciparum / Q000097:blood* / Q000503:physiopathology; D008875:Middle Aged; D019007:P-Selectin; D018512:Parasitemia / Q000469:parasitology; D010980:Platelet Membrane Glycoproteins / Q000097:blood* / Q000502:physiology; D044465:White People
D015703:Antigens, CD; D019007:P-Selectin; D010980:Platelet Membrane Glycoproteins