Diagnostic significance of prostate specific antigen and the development of a mass screening system for prostate cancer.
OBJECTIVE
The significance of prostate specific antigen (PSA) in the mass screening for prostate cancer was investigated.


METHODS
A total of 4,375 PSA, digital rectal and transrectal ultrasonographic examinations was performed on 3,526 subjects.


RESULTS
Among the 3 modalities, PSA had the highest sensitivity (80.4%) and positive predictive value (45.1%). We established age-specific reference PSA ranges for normal Japanese men, and demonstrated the significance of PSA density and PSA velocity.


CONCLUSIONS
The significance of PSA as a prostate cancer screening modality should be evaluated across multiple age ranges and in combination with previous PSA data and/or prostate volume.
Imai
K
K
Department of Urology, Gunma University School of Medicine, Japan.
Ichinose
Y
Y
Kubota
Y
Y
Yamanaka
H
H
Sato
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D010173:Palpation; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity; D014463:Ultrasonography
D017430:Prostate-Specific Antigen