Local anesthetics as adjuvant analgesics.
Local anesthetics administered to block nerve conduction for surgical anesthesia and to provide analgesia in management of acute pain have become a standard of anesthesiology practice. These drugs have had an important role in the multimodality management of chronic pain as well, and this role is expanding since the revival of systemic administration. Local anesthetics are analgesics, albeit not in the traditional clinical and pharmacologic sense. Evidence suggests that intravenous administration is an effective treatment in chronic neuropathic pain syndromes. There is also evidence that intravenous local anesthetics can relieve acute pain. Furthermore, the novel idea that acute procedural and postprocedural pain control with local anesthetics could prevent the development of chronic pain syndromes, including chronic neuropathic pain syndromes, adds another important potential dimension to the role of local anesthetics in pain management.
Backonja
M M
MM
Department of Neurology, University of Wisconsin Medical School, Madison.
D000277:Adjuvants, Pharmaceutic / Q000627:therapeutic use*; D000700:Analgesics / Q000627:therapeutic use*; D000779:Anesthetics, Local / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D002908:Chronic Disease; D002986:Clinical Trials as Topic; D006801:Humans; D010166:Palliative Care
D000277:Adjuvants, Pharmaceutic; D000700:Analgesics; D000779:Anesthetics, Local