title: Spirometry and ventilation-perfusion inequality in patients with mild allergic asthma before and during the pollen season.
abstract: Several studies on asthma have shown a low correlation between gas exchange and spirometry, especially after treatment with bronchodilators. The aim of the present study was therefore to examine both spirometry results and gas exchange during a pollen-free period and at the end of the pollen season in patients with mild and well-controlled allergic asthma. Pulmonary gas exchange was studied using a modified form of the multiple inert gas elimination technique. Lung volumes and forced expiratory flows were measured by common spirometry. During the non-pollen season, spirometry and forced expiratory flows were within the reference values in all but one patient, who had decreased indices for airway flow. Three other patients showed signs of minor gas exchange impairment. During the pollen season, FRC was slightly increased (P < 0.05) and MEF50 was slightly decreased (P < 0.05) for the group. Two patients had an increased index for gas exchange impairment (log SDQ was 0.64 and 0.59) and four patients had borderline log SDQ (0.50 to 0.56). However, the mean log SDQ was not increased in the pollen season. The results show that, both in the pollen season and in the pollen-free season, low degrees of gas exchange impairment could be present in pollen allergic asthmatic patients despite normal spirometry. The low degree of gas exchange impairment in some patients indicates the presence of airway inflammation with oedema and/or secretion. However, high degrees of ventilation-perfusion inequality were not observed in these patients where air flow rates were mainly normal.
authors.affiliation: Department of Clinical Physiology, University Hospital, Huddinge, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Lagerstrand
authors.forename: M
authors.initials: M
authors.lastname: Skedinger
authors.forename: E
authors.initials: E
authors.lastname: Ihre
authors.forename: G
authors.initials: G
authors.lastname: Halldén
authors.forename: O
authors.initials: O
authors.lastname: Zetterström
mesh_terms: D000328:Adult; D001249:Asthma / Q000503:physiopathology*; D015415:Biomarkers; D001784:Blood Gas Analysis; D005260:Female; D006801:Humans; D008297:Male; D011058:Pollen / Q000276:immunology*; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012039:Regional Blood Flow / Q000502:physiology; D012129:Respiratory Function Tests; D012621:Seasons; D013147:Spirometry; D014692:Ventilation-Perfusion Ratio / Q000502:physiology*
chemical_list: D015415:Biomarkers