Biologic differences between early- and late-onset Alzheimer disease.
Large neurons shrink and synapses are lost in the neocortex as a function of normal aging, but different parts of the central nervous system vary in susceptibility to age changes. Thus, early-onset disease may appear different from late cases due to premorbid age changes rather than because of different pathogenesis.
Terry
R D
RD
Department of Neurosciences, University of California, San Diego, La Jolla 92093-0624, USA.
D017668:Age of Onset; D000375:Aging / Q000502:physiology*; D000544:Alzheimer Disease / Q000175:diagnosis*; D001921:Brain / Q000502:physiology*; D016923:Cell Death; D003937:Diagnosis, Differential; D006801:Humans; D013997:Time Factors