Serum 25-hydroxyvitamin D3 levels decreased in impaired glucose tolerance and diabetes mellitus.
A cross-sectional survey was carried out in a New Zealand Polynesian and Caucasian workforce of 5677 staff aged 40-64 years to determine whether serum concentrations of 25-hydroxyvitamin D3 are altered in people with newly diagnosed diabetes mellitus and impaired glucose tolerance (IGT). Serum 25-hydroxyvitamin D3 concentration was significantly lower in newly detected cases with diabetes and IGT (n = 238) compared with controls individually matched by sex, age (+/- 2 years), ethnicity, and date of interview (mean (S.D.): 69 (31) vs. 76 (34) nmol/l; P = 0.0016). Among controls, serum concentrations were significantly lower in Maori (mean (S.E.) = 65 (5) nmol/l; P = 0.0013) and Pacific Islanders (59 (4) nmol/l; P = 0.0001) compared with Europeans (82 (3) nmol/l), after adjusting for age, sex, and time of year. We conclude that diabetes and IGT are associated with low serum concentrations of 25-hydroxyvitamin D3 and that low concentrations of this hormone in New Zealand Polynesians may partly explain their increased prevalence of diabetes/IGT compared with Europeans.
Scragg
R
R
Department of Community Health, University of Auckland, New Zealand.
Holdaway
I
I
Singh
V
V
Metcalf
P
P
Baker
J
J
Dryson
E
E
D000328:Adult; D001208:Asia / Q000453:epidemiology; D001794:Blood Pressure; D002112:Calcifediol / Q000097:blood*; D003430:Cross-Sectional Studies; D003920:Diabetes Mellitus / Q000097:blood* / Q000503:physiopathology; D005006:Ethnicity; D005060:Europe / Q000208:ethnology; D005260:Female; D018149:Glucose Intolerance / Q000097:blood* / Q000503:physiopathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D009520:New Zealand; D016017:Odds Ratio; D010507:Periodicity; D011114:Polynesia / Q000208:ethnology; D012016:Reference Values; D012621:Seasons; D012727:Sex Characteristics; D044465:White People
D002112:Calcifediol