Systemic effects of epidural dexamethasone injections.
OBJECTIVE
to evaluate potential systemic effects of a single epidural injection of dexamethasone.


METHODS
each of nine patients (five males and four females, mean age 47 +/- 11.8 years) admitted for sciatica was given a single epidural injection of 15 mg dexamethasone acetate. Before the injection (D0) and two (D2), seven (D7) and 21 (D21) days after the injection, the following laboratory tests were performed: serum cortisol and ACTH in the morning after an overnight fast, free cortisol in a 24-hour urine collection, fasting serum levels of glucose, triglycerides and cholesterol, serum levels of sodium and potassium. Blood pressure was measured on D0, D2, and D7.


RESULTS
Serum cortisol, ACTH and urinary cortisol were profoundly decreased on D2 and D7 but normal on D21. There were no changes in fasting serum glucose, triglycerides, cholesterol, sodium or potassium levels.


CONCLUSIONS
a single epidural injection of 15 mg dexamethasone acetate is associated with transient adrenal suppression, denoting passage of the steroid into the systemic bloodstream. However, evidence of hypercorticism is usually lacking.
Maillefert
J F
JF
Department of Rheumatology, General Hospital, Dijon, France.
Aho
S
S
Huguenin
M C
MC
Chatard
C
C
Peere
T
T
Marquignon
M F
MF
Lucas
B
B
Tavernier
C
C
D000324:Adrenocorticotropic Hormone / Q000378:metabolism; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage*; D001794:Blood Pressure / Q000187:drug effects; D003907:Dexamethasone / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000378:metabolism; D007268:Injections, Epidural; D008297:Male; D008875:Middle Aged; D012585:Sciatica / Q000188:drug therapy* / Q000378:metabolism / Q000503:physiopathology
D000893:Anti-Inflammatory Agents; D003907:Dexamethasone; D000324:Adrenocorticotropic Hormone; D006854:Hydrocortisone