title: Pharmacokinetics of analgesics, sedatives and anaesthetic agents during cardiopulmonary bypass.
abstract: CPB produces changes in the blood-gas partition coefficient dependent on the prime used and temperature. Fortunately, the overall effect for hypothermic CPB and a crystalloid prime is only +2%. A volatile agent started during hypothermic CPB takes longer to equilibrate and agents already in use need to re-equilibrate, potentially changing the depth of anaesthesia, until equilibration is complete. As these agents are metabolized to a small degree and washout is fast, the duration of action is not prolonged after CPB.
authors.affiliation: Department of Anaesthesia, Addenbrooke's Hospital, Cambridge.
authors.forename: J A
authors.initials: JA
authors.lastname: Gedney
authors.forename: S
authors.initials: S
authors.lastname: Ghosh
mesh_terms: D000701:Analgesics, Opioid / Q000493:pharmacokinetics*; D000777:Anesthetics / Q000493:pharmacokinetics*; D001569:Benzodiazepines / Q000493:pharmacokinetics; D002315:Cardiopulmonary Bypass; D006801:Humans; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics*
chemical_list: D000701:Analgesics, Opioid; D000777:Anesthetics; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines