title: Hypertrophic cardiomyopathy associated with tacrolimus in paediatric transplant patients.
abstract: Reported side-effects of tacrolimus, a potent immunosuppressive agent, have not included cardiotoxicity. We describe 5 consecutive paediatric transplant recipients (3 small bowel with or without liver and 2 liver) who received tacrolimus. 2 developed congestive heart failure and hypertrophic obstructive cardiomyopathy which resolved after changing to cyclosporin. In the other 3 patients the cardiomyopathy regressed or improved with a lower dose of tacrolimus or after stopping the drug.
authors.affiliation: Children's Hospital of Western Ontario, University of Western Ontario, London, Canada.
authors.forename: P
authors.initials: P
authors.lastname: Atkison
authors.forename: G
authors.initials: G
authors.lastname: Joubert
authors.forename: A
authors.initials: A
authors.lastname: Barron
authors.forename: D
authors.initials: D
authors.lastname: Grant
authors.forename: K
authors.initials: K
authors.lastname: Paradis
authors.forename: E
authors.initials: E
authors.lastname: Seidman
authors.forename: W
authors.initials: W
authors.lastname: Wall
authors.forename: H
authors.initials: H
authors.lastname: Rosenberg
authors.forename: J
authors.initials: J
authors.lastname: Howard
authors.forename: S
authors.initials: S
authors.lastname: Williams
mesh_terms: D001794:Blood Pressure / Q000187:drug effects; D002312:Cardiomyopathy, Hypertrophic / Q000139:chemically induced*; D002675:Child, Preschool; D003106:Colon / Q000637:transplantation; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D007223:Infant; D016031:Liver Transplantation; D008297:Male; D011183:Postoperative Complications / Q000139:chemically induced*; D016559:Tacrolimus / Q000009:adverse effects* / Q000097:blood
chemical_list: D016559:Tacrolimus