title: Surgical combination therapy for vitiligo and piebaldism.
abstract: BACKGROUND
  Refractory and stable defects of vitiligo and piebaldism may be unresponsive to medical therapy. Melanocyte transplantation can restore the normal pigmentation in some selected patients.
  
  
  OBJECTIVE
  To evaluate the efficacy of additional mini-grafting with 1.0-1.2-mm punch grafts to complete the restoration of achromic defects when performing surgical correction of leukoderma.
  
  
  METHODS
  Eight patients with refractory stable leukoderma were treated with melanocyte transplantation; three with segmental vitiligo had epidermal shave, by removing the hyperpigmented macules at the periphery of achromic lesions; two others received suction epidermal grafts; and three subjects were treated by in vitro cultured epidermal autografts. All patients received additional mini-grafts in areas of residual achromia.
  
  
  RESULTS
  The depigmented defects were 100% restored in seven patients, and in one subject 80% improvement was observed.
  
  
  CONCLUSIONS
  Surgical methods, followed by additional mini-grafting, may be helpful to restore completely the depigmented defects when residual achromia, after treatment with the methods described above, is still present.
authors.affiliation: Department of Internal Medicine, Universidad del Valle, Cali, Colombia.
authors.forename: R
authors.initials: R
authors.lastname: Falabella
authors.forename: M
authors.initials: M
authors.lastname: Barona
authors.forename: C
authors.initials: C
authors.lastname: Escobar
authors.forename: I
authors.initials: I
authors.lastname: Borrero
authors.forename: A
authors.initials: A
authors.lastname: Arrunategui
mesh_terms: D002478:Cells, Cultured; D003131:Combined Modality Therapy; D004817:Epidermis / Q000601:surgery / Q000637:transplantation; D004954:Esthetics; D006801:Humans; D008544:Melanocytes / Q000637:transplantation; D016116:Piebaldism / Q000601:surgery*; D016038:Skin Transplantation / Q000379:methods; D014182:Transplantation, Autologous; D014820:Vitiligo / Q000601:surgery*