Effects of an every other day rapid kindling procedure in prenatally protein malnourished rats.
Prenatally protein (6/25) rats have been reported to require significantly more stimulations to attain a stage 5 seizure than well-nourished controls (25/25) when using either a traditional or rapid every day, kindling procedure. In the present study, a rapid kindling procedure was utilized where both prenatally malnourished and control rats received every other day perforant path kindling (50 Hz, 10 s train) 12 times a day at 5-min intervals. Using this procedure, stage 5 seizures and a fully state were attained in both nutritional groups at approximately the same rate. It is postulated that it is the every other day component of the present procedure which overcomes seizure-induced inhibition in the 6/25 subjects, thereby allowing them to attain stage 5 seizures at the same rate as controls.
Shultz
P L
PL
Center for Behavioral Development and Mental Retardation, Boston University School of Medicine, MA 02118, USA.
Tonkiss
J
J
Morgane
P J
PJ
Bronzino
J D
JD
Galler
J R
JR
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D004567:Electrodes, Implanted; D005260:Female; D007696:Kindling, Neurologic / Q000502:physiology*; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011502:Protein-Energy Malnutrition / Q000503:physiopathology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000503:physiopathology; D013997:Time Factors