title: Effect of vitamin E supplementation on immune status and alpha-tocopherol in plasma of piglets.
abstract: Twelve (Yorkshire) gilts were assigned to 2 dietary fat supplement groups starting at 57 d of gestation. Group 1 received no fat and Group 2 was supplemented with 5% Canola oil. Each group was supplemented with 0.1 ppm Se and 22 IU of DL-alpha-tocopherol acetate/kg of feed. Colostrum (d 0) and milk (7, 14, 21 and 28 d post partum) were sampled from gilts. At farrowing 3 piglets from each gilt of both groups were injected with alpha-tocopherol at birth (500 IU) and at 7 and 14 d (1,000 IU) of age and 3 piglets were injected with saline and used as control. Blood samples were taken from the newborn piglets at birth and at 7, 14, 21, 28 and 35 d of age. alpha-Tocopherol concentration in the colostrum of gilts was significantly higher than in the milk. Plasma alpha-tocopherol concentrations and antibody titres to Key-hole limpet haemocyanin of piglets injected with vitamin E were significantly higher than the control piglets. Vitamin E injected piglets had significantly higher alpha-tocopherol concentrations in spleen, liver, kidney, heart, lung and hip muscle than the control piglets.
authors.affiliation: Centre for Food and Animal Research, Agricultural and Agri-Food Canada, Ottawa, ON.
authors.forename: M
authors.initials: M
authors.lastname: Hidiroglou
authors.forename: T R
authors.initials: TR
authors.lastname: Batra
authors.forename: E R
authors.initials: ER
authors.lastname: Farnworth
authors.forename: F
authors.initials: F
authors.lastname: Markham
mesh_terms: D000818:Animals; D000906:Antibodies / Q000097:blood; D000941:Antigens / Q000276:immunology; D001835:Body Weight; D003126:Colostrum / Q000378:metabolism; D004032:Diet; D005260:Female; D006433:Hemocyanins / Q000276:immunology; D007109:Immunity / Q000187:drug effects*; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008892:Milk / Q000378:metabolism; D009928:Organ Specificity; D013552:Swine / Q000097:blood / Q000276:immunology*; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood* / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D000906:Antibodies; D000941:Antigens; D007074:Immunoglobulin G; D014810:Vitamin E; D006433:Hemocyanins; C032808:keyhole-limpet hemocyanin