title: Drug induced myopia associated with treatment for gynecological problems.
abstract: We present three cases of women who developed acute transient myopia caused by drugs for gynecological problems. One patient was treated with disothiazide for premenstrual edema. The second had acute cystitis and was treated by sulphonamide and the third developed myopia coincident with metronidazole treatment for trichomonas vaginalis. We followed these patients by A scan ultrasonographic ocular measurements, documenting reduction of the anterior chamber depth combined with lens thickening. The ocular and myopic changes cleared up completely on discontinuation of the causative agent. The possible mechanism is thought to be an allergic reaction to the drug.
authors.affiliation: Goldschleger Eye Institute, Chaim Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Grinbaum
authors.forename: I
authors.initials: I
authors.lastname: Ashkenazi
authors.forename: I
authors.initials: I
authors.lastname: Avni
mesh_terms: D000208:Acute Disease; D000328:Adult; D000867:Anterior Chamber / Q000000981:diagnostic imaging / Q000187:drug effects; D005260:Female; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000627:therapeutic use; D007908:Lens, Crystalline / Q000187:drug effects / Q000473:pathology; D008795:Metronidazole / Q000009:adverse effects* / Q000627:therapeutic use; D009216:Myopia / Q000139:chemically induced* / Q000473:pathology; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects* / Q000627:therapeutic use; D014463:Ultrasonography
chemical_list: D006852:Hydrochlorothiazide; D008795:Metronidazole; D015662:Trimethoprim, Sulfamethoxazole Drug Combination