title: Experience with intraluminal radiotherapy in advanced oesophageal cancer.
abstract: Despite improvement in the diagnostic modalities, surgical technique, chemotherapy and radiotherapy, mortality and morbidity due to carcinoma esophagus continues to be dismal. Combination of external and intraluminal radio therapy (ILRT) has emerged as a powerful and promising palliative therapy in this disease. Thirty four patients with inoperable cancer esophagus treated with ILRT during June 1991 to December 1993 were evaluated to assess its palliative effects. Seventeen of these patients had received additional chemotherapy and external radiotherapy. Thirteen patients received only radiotherapy (both external radiotherapy + ILRT) and the remaining 4 received only ILRT. They were followed up for a mean period of 8.3 months (range 2 to 28 months) during which one patient was lost to follow up. Eight had a follow up of less than 6 months. Eight (33%) amongst the remaining 25 patients were considered disease free, 15 had recurrent and progressive disease, one developed metastasis and one patient died. In 21 (66%) dysphagia markedly improved. Nine (26%) patients survived beyond 1 year and the median survival for all patients was 8 months. Associated radiation morbidity was documented in 13 (38%) patients. We conclude that combination of external radiotherapy and ILRT is an effective and safe therapy for inoperable esophageal malignancies.
authors.affiliation: Department of Radiation Oncology, Institute Rotary Cancer Hospital, All India Institute of Medical Sciences, Ansari Nagar, New Delhi.
authors.forename: B K
authors.initials: BK
authors.lastname: Mohanti
authors.forename: N K
authors.initials: NK
authors.lastname: Shukla
authors.forename: S
authors.initials: S
authors.lastname: Chawla
authors.forename: T
authors.initials: T
authors.lastname: Ganesh
authors.forename: S V
authors.initials: SV
authors.lastname: Deo
authors.forename: K K
authors.initials: KK
authors.lastname: Thakur
authors.forename: V
authors.initials: V
authors.lastname: Raina
authors.forename: P K
authors.initials: PK
authors.lastname: Mohanta
authors.forename: G K
authors.initials: GK
authors.lastname: Rath
mesh_terms: D001918:Brachytherapy; D002277:Carcinoma / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D002588:Cesium Radioisotopes / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000627:therapeutic use; D004938:Esophageal Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008727:Methotrexate / Q000627:therapeutic use; D008875:Middle Aged; D010166:Palliative Care; D011882:Radiotherapy, High-Energy; D013997:Time Factors
chemical_list: D002588:Cesium Radioisotopes; D002945:Cisplatin; D008727:Methotrexate