title: Rho as a regulator of the cytoskeleton.
abstract: Many cell functions, including maintenance of morphology, aggregation, motility, membrane ruffling, smooth-muscle contraction, cytokinesis in mammals and bud formation in yeast, are regulated through the dynamic reorganization of actin filaments. Although it has long been known that Ca2+ is a key regulator of the cytoskeleton, evidence is now accumulating that Rho, a Ras-related small GTP-binding protein, is another important regulator of these actin-dependent cell functions.
authors.affiliation: Department of Molecular Biology and Biochemistry, Osaka University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takai
authors.forename: T
authors.initials: T
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: H
authors.initials: H
authors.lastname: Nakanishi
mesh_terms: D000209:Acute-Phase Proteins / Q000502:physiology*; D003599:Cytoskeleton / Q000502:physiology*; D017434:Protein Structure, Tertiary
chemical_list: D000209:Acute-Phase Proteins; C010781:acute-phase protein rho