The role of T-cells in inflammatory kidney disease.
The fundamental role of cell-mediated immunity in inflammatory disease of the kidney has been established for some time. This review focusses on the recent advances in our understanding of the role of T-cells in the pathogenesis both of glomerulonephritis and interstitial nephritis. In particular, the increasing experimental evidence for a functional role for T-cells in promoting disease initiation and progression is examined. The ever increasing variety of T-cell-effector functions and their relevance are also discussed.
Main
I W
IW
Department of Adult Nephrology, Monash Medical Centre, Clayton, Victoria, Australia.
Atkins
R C
RC
D000818:Animals; D006801:Humans; D007108:Immune Tolerance; D009393:Nephritis / Q000276:immunology* / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology*