[The functional characteristics of Gs-protein in the developing mammalian kidney].
Characteristics of G-proteins were studied in renal medulla of rats and mice of different ages. It was established that G-protein alpha-subunit gene expression has a specific dynamics with maximum on the 5-8-th day of life and at the end of weaning. It was shown that vasopressin does not stimulate G-protein GTPase activity in membrane preparations from immature kidneys. The differences of G-protein chromatographic characteristics were revealed. It is suggested that the development of vasopressin sensitivity of the kidney is related with the changes in G-protein system.
Zelenina
M N
MN
Solenov
E I
EI
Zelenin
S M
SM
Ivanova
L N
LN
D000375:Aging / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D020558:GTP Phosphohydrolases / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000032:analysis / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental / Q000502:physiology; D007679:Kidney Medulla / Q000254:growth & development* / Q000378:metabolism; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D051381:Rats; D017208:Rats, Wistar; D014667:Vasopressins / Q000502:physiology; D014886:Weaning
D014667:Vasopressins; D020558:GTP Phosphohydrolases; D019204:GTP-Binding Proteins