title: Hereditary multiple glomus tumors involving the glans penis. A case report and review of the literature.
abstract: BACKGROUND
  Multiple glomus tumors are extremely rare and seldom demonstrate malignant change.
  
  
  OBJECTIVE
  To describe an exceptionally rare case of familial multiple glomus tumors involving the glans penis.
  
  
  METHODS
  Multiple glomus tumors in a father and son were studied by light and electron microscopy.
  
  
  RESULTS
  The clinical presentation of the two patients was similar, and atypical glomus cells were identified in both son and father. The histology of the tumor cells suggested that they were malignant, yet the clinical course has been benign.
  
  
  CONCLUSIONS
  Despite their malignant histologic appearance, the behavior of familial glomus tumors is benign. A conservative approach to treatment appears warranted. The diagnosis and management of these lesions should be based on clinical behavior rather than histopathology.
authors.affiliation: Department of Plastic and Reconstructive Surgery, University of Tsukuba, Ibaraki, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kiyosawa
authors.forename: Y
authors.initials: Y
authors.lastname: Umebayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Nakayama
authors.forename: S
authors.initials: S
authors.lastname: Soeda
mesh_terms: D000328:Adult; D002471:Cell Transformation, Neoplastic; D005190:Family; D005260:Female; D005918:Glomus Tumor / Q000235:genetics* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics* / Q000473:pathology; D010412:Penile Neoplasms / Q000235:genetics* / Q000473:pathology; D014846:Vulvar Neoplasms / Q000473:pathology