title: Allelic losses on chromosomes 14, 10, and 1 in atypical and malignant meningiomas: a genetic model of meningioma progression.
abstract: To investigate chromosomal events that underlie formation and progression of meningiomas, we have examined a set of 18 benign (WHO grade I), 15 atypical (grade II), and 13 anaplastic/malignant (grade III) meningiomas for loss of heterozygosity (LOH) on chromosomes 1p, 6p, 9q, 10q, and 14q. Frequent loss of loci on these chromosomes was seen in grade II and grade III tumors, specifically, 14q (II and III, 47 and 55%), 1p (40 and 70%), and 10q (27 and 40%). In contrast, LOH for these loci was infrequent in benign meningiomas, specifically, 14q (0%), 1p (11%), and 10q (12%). The smallest common regions of deletion that could be defined were 14q24-q32, 1p32-pter, and 10q24-qter. These observations indicate the likely presence of tumor suppressor genes in these regions that are involved in the development of WHO grade II and grade III meningiomas. Because LOH for loci on chromosomes 1p and 10q was found in tumors of all grades and because the frequency of LOH in all three regions increased with tumor grade, these results would support a model for the formation of aggressive meningiomas through tumor progression.
authors.affiliation: Department of Molecular Genetics, University of Cincinnati College of Medicine, Ohio 45267, USA.
authors.forename: M
authors.initials: M
authors.lastname: Simon
authors.forename: A
authors.initials: A
authors.lastname: von Deimling
authors.forename: J J
authors.initials: JJ
authors.lastname: Larson
authors.forename: R
authors.initials: R
authors.lastname: Wellenreuther
authors.forename: P
authors.initials: P
authors.lastname: Kaskel
authors.forename: A
authors.initials: A
authors.lastname: Waha
authors.forename: R E
authors.initials: RE
authors.lastname: Warnick
authors.forename: J M
authors.initials: JM
authors.lastname: Tew
authors.forename: A G
authors.initials: AG
authors.lastname: Menon
mesh_terms: D000328:Adult; D000368:Aged; D000483:Alleles; D001932:Brain Neoplasms / Q000235:genetics*; D002874:Chromosome Mapping; D002878:Chromosomes, Human, Pair 1; D002879:Chromosomes, Human, Pair 10; D002883:Chromosomes, Human, Pair 14; D005260:Female; D006579:Heterozygote; D006801:Humans; D008297:Male; D008579:Meningioma / Q000235:genetics* / Q000473:pathology; D008875:Middle Aged; D017384:Sequence Deletion