[LDL-receptor-related protein].
The LDL-receptor-related protein is a multifunctional endocytotic receptor that clear apo E- and/or lipoprotein lipase-enriched lipoproteins, proteases such as alpha 2-macroglobulin plasminogen and activator inhibitor-1 (PAI-1), Pseudomonas exotoxin A and probably vitellogenin from blood circulation. Its role in plasma chylomicron remnant clearance has been postulated, and recently has been demonstrated by using its inhibitor; receptor-associated protein (RAP) in LDL receptor knockout mice.
Ishibashi
S
S
Third Department of Internal Medicine, University of Tokyo.
D000818:Animals; D005098:Exotoxins / Q000378:metabolism; D006801:Humans; D008074:Lipoproteins / Q000378:metabolism; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D051379:Mice; D017395:Plasminogen Activator Inhibitor 1 / Q000378:metabolism; D011485:Protein Binding; D011971:Receptors, Immunologic / Q000737:chemistry; D014819:Vitellogenins / Q000378:metabolism; D000511:alpha-Macroglobulins / Q000378:metabolism
D005098:Exotoxins; D008074:Lipoproteins; D026503:Low Density Lipoprotein Receptor-Related Protein-1; D017395:Plasminogen Activator Inhibitor 1; D011971:Receptors, Immunologic; D014819:Vitellogenins; D000511:alpha-Macroglobulins