Sickle cell anaemia in Nigeria: a comparison between Benin and Lagos.
The clinical and haematological features of 77 patients of Bini and 107 patients of Yoruba origin with homozygous sickle cell (SS) disease have been compared. The Bini population were generally younger and had a slightly lower incidence of alpha thalassaemia but even after correction for age and alpha thalassaemia status, this group had significantly lower HbA2 and higher HbF and MCV values. Clinically the Bini group had significantly less dactylitis and more acute chest syndrome. The decreased frequency of dactylitis is consistent with the higher HbF level in the Bini population and the mechanism of the other effects are discussed.
Akenzua
G
G
Dept of Child Health, University of Benin Teaching Hospital, Nigeria.
Akinyanju
O
O
Kulozik
A
A
Whitehead
S
S
Morris
J
J
Serjeant
B E
BE
Serjeant
G
G
D000293:Adolescent; D000328:Adult; D017677:Age Distribution; D000755:Anemia, Sickle Cell / Q000097:blood* / Q000150:complications / Q000208:ethnology* / Q000235:genetics; D002648:Child; D002675:Child, Preschool; D004909:Erythrocyte Indices; D005006:Ethnicity; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D006443:Hemoglobin A2 / Q000032:analysis; D006801:Humans; D015994:Incidence; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009549:Nigeria / Q000453:epidemiology; D017678:Sex Distribution; D011795:Surveys and Questionnaires
D006443:Hemoglobin A2; D005319:Fetal Hemoglobin