Searching for complex disease genes: can it be made any easier?
The search for complex disease genes is gaining momentum. Recent guidelines for expediting this effort, such as "intelligent" genome scanning and statistical criteria for detecting weak signals indicative of linkage, are discussed, with special reference to psychiatric disorders.
Baron
M
M
Department of Medical Genetics, New York State Psychiatric Institute, NY 10032, USA.
D001482:Base Composition; D002874:Chromosome Mapping / Q000191:economics / Q000379:methods* / Q000706:statistics & numerical data; D003362:Cost-Benefit Analysis; D004843:Epistasis, Genetic; D005189:False Positive Reactions; D005796:Genes; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D001523:Mental Disorders / Q000235:genetics*