title: [Malignant transformation of odontogenic cysts].
abstract: Five out of 4,172 operated maxillary cysts (3 developed within the maxillary and 2 in the mandible) presented a malignant change of epithelium. In all these 5 cases histology demonstrated a transition from normal to cancerous epithelium. The overall percentage of malignant change was of 0.12%, with 0.077% for non-keratinized epithelium lining odontogenic cysts (3 cases) and 0.65%, that is 8 times higher, for keratinized ones (2 cases). Keratinization of cystic epithelium and chronic inflammatory lesions were the main risk factors.
authors.affiliation: Clinique de Chirurgie Orale et Maxillo-Faciale, Université de Médecine et de Pharmacie, laşi, Roumanie.
authors.forename: G C
authors.initials: GC
authors.lastname: Timoşca
authors.forename: C
authors.initials: C
authors.lastname: Cotuţiu
authors.forename: L
authors.initials: L
authors.lastname: Gavriliţà
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D004814:Epidermal Cyst / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D007633:Keratins; D008297:Male; D008336:Mandibular Diseases / Q000473:pathology*; D008339:Mandibular Neoplasms / Q000473:pathology*; D008439:Maxillary Diseases / Q000473:pathology*; D008441:Maxillary Neoplasms / Q000473:pathology*; D008875:Middle Aged; D009807:Odontogenic Cysts / Q000473:pathology*; D011842:Radicular Cyst / Q000473:pathology
chemical_list: D007633:Keratins