Onlay silicone and hydroxyapatite-tricalciumphosphate composite (HAP-TCP) blocks interfere with nasal bone growth in rabbits.
We investigated how a new type of synthetic porous hydroxyapatite ceramic (HAP-TCP) acts when it is implanted in growing membranous bone. Seventy-six New Zealand White infant male rabbits (4-week-olds) were used. Rabbits received HAP-TCP block or silicone block implantation in their right nasal bone. The left nasal bone was used for a sham. Serial or cross-sectional examinations by morphometry, radiology, blood biochemistry, and histology were carried out. Both the HAP-TCP and silicone groups exhibited no systemic growth disturbance in terms of morphometry and blood biochemistry. Dual energy x-ray absorptiometry (DEXA) revealed, however, a decrease in the bone mineral content (BMC) of the right nasal bone in the silicone group. Histology revealed a superior affinity of HAP-TCP to bone tissue than that of silicone. When a HAP-TCP block was implanted under the periosteum it bonded directly to bone tissue. However, sinking of the implants into the bone tissue were noted both in the HAP-TCP and the silicone groups in longitudinal observation. These results suggest that although HAP-TCP has superior affinity to bone tissue, this by itself is not enough sufficient reason to believe that HAP-TCP can be effectively applied during the growth period.
Arakaki
M
M
Department of Plastic and Reconstructive Surgery, Nagasaki University School of Medicine, Japan.
Yamashita
S
S
Mutaf
M
M
Naito
S
S
Fujii
T
T
D015502:Absorptiometry, Photon; D000469:Alkaline Phosphatase / Q000097:blood; D000818:Animals; D001672:Biocompatible Materials; D015519:Bone Density; D001862:Bone Resorption / Q000473:pathology; D002118:Calcium / Q000097:blood; D002130:Calcium Phosphates / Q000737:chemistry; D017886:Durapatite / Q000737:chemistry; D006253:Haversian System / Q000473:pathology; D008137:Longitudinal Studies; D008297:Male; D008852:Microradiography; D009295:Nasal Bone / Q000033:anatomy & histology / Q000254:growth & development* / Q000601:surgery*; D016348:Osseointegration; D010521:Periosteum / Q000033:anatomy & histology / Q000601:surgery; D010758:Phosphorus / Q000097:blood; D016062:Porosity; D019736:Prostheses and Implants; D011817:Rabbits; D012828:Silicones / Q000737:chemistry
D001672:Biocompatible Materials; D002130:Calcium Phosphates; D012828:Silicones; C485828:alpha-tricalcium phosphate; C485830:tetracalcium phosphate; D010758:Phosphorus; C485838:calcium phosphate, monobasic, anhydrous; D017886:Durapatite; C020243:calcium phosphate; D000469:Alkaline Phosphatase; C485829:calcium phosphate, dibasic, anhydrous; D002118:Calcium