title: Toxicity of complex chemical mixtures: acute and long-term effects on different life stages of zebrafish (Brachydanio rerio).
abstract: Acute and long-term toxicity of 3,4-dichloroaniline and lindane to zebrafish were examined in tap water and water from the Rhine River and the toxicity of the binary mixture 3,4-dichloroaniline/lindane in tap water was investigated. The acute toxicity of 3,4-dichloroaniline and lindane was not influenced by the complex matrix of river water compared with tap water. The binary mixture of 3,4-dichloroaniline and lindane demonstrated an additive effect in the acute test. The survival rate of early life stages in river water was reduced by lindane (80 micrograms/liter), whereas the effects of 3,4-dichloroaniline on survival and growth were visible but not significant. The binary mixture of 2 micrograms/liter, 3,4-dichloroaniline and 40 micrograms/liter lindane in tap water had an influence on growth on the early life stages of zebrafish.
authors.affiliation: Department II, Ecotoxicology, University of Mainz, Federal Republic of Germany.
authors.forename: U
authors.initials: U
authors.lastname: Ensenbach
authors.forename: R
authors.initials: R
authors.lastname: Nagel
mesh_terms: D000814:Aniline Compounds / Q000633:toxicity*; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005618:Fresh Water; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D007928:Lethal Dose 50; D015996:Survival Rate; D013997:Time Factors; D014874:Water Pollutants, Chemical / Q000633:toxicity*; D015027:Zebrafish / Q000002:abnormalities / Q000254:growth & development* / Q000502:physiology
chemical_list: D000814:Aniline Compounds; D014874:Water Pollutants, Chemical; C014464:3,4-dichloroaniline; D001556:Hexachlorocyclohexane