Depletion of myelin-basic-protein autoreactive T cells by T-cell vaccination: pilot trial in multiple sclerosis.
In a pilot trial, eight patients with multiple sclerosis were matched to control patients and received T-cell vaccination with irradiated T cells reactive to myelin basic protein (MBP) to deplete circulating MBP-reactive T cells. In the 2 years before and after vaccination, exacerbations decreased in five vaccinated patients (numbers 1, 2, 6-8) with relapsing-remitting disease from sixteen to three, respectively, and from twelve to ten in their matched controls. Magnetic resonance imaging showed a mean 8.0% increase in brain lesion size in the vaccinated patients compared with a 39.5% increase in the controls. Lesions and/or relapses worsened in three cases after vaccination in association with reappearance of circulating MBP-reactive T cells.
Medaer
R
R
Multiple Sclerosis Research and Immunology Unit, Dr L Willems Instituut, Diepenbeek, Belgium.
Stinissen
P
P
Truyen
L
L
Raus
J
J
Zhang
J
J
D000328:Adult; D015551:Autoimmunity; D001921:Brain / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008212:Lymphocyte Depletion; D008279:Magnetic Resonance Imaging; D008297:Male; D009103:Multiple Sclerosis / Q000276:immunology / Q000473:pathology / Q000628:therapy*; D004676:Myelin Basic Protein / Q000276:immunology*; D010865:Pilot Projects; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology* / Q000528:radiation effects; D014611:Vaccination; D014612:Vaccines
D004676:Myelin Basic Protein; D014612:Vaccines