Effect of dextran on plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) during surgery.
Dextran is known to increase the plasminogen activation rate in vitro and to decrease the alpha2-antiplasmin activity. We decided to explore the effect of dextran on plasma tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-1) during surgical trauma. Thirty-one patients undergoing elective surgery were given 500 ml of 6% dextran 70. Another nine patients serving as controls were given 500 ml of a glucose-electrolyte solution. The activities of t-PA and PAI-1 during surgery were determined, as was the concentration of t-PA antigen. PAI-1 activity was decreased by 19% after infusion of 250 ml of dextran. After 500 ml, the activity was reduced by 22% (both P < 0.05). The activity of t-PA was increased by 43% and 29% (both P < 0.05) and the antigenic amount of t-PA was increased by 18% and 15% (both P < 0.05) after infusion of 250 ml and 500 ml of dextran, respectively. No changes in these variables were observed in the control patients. It is concluded that infusion of dextran promotes fibrinolysis by enhancing plasminogen activation in patients subjected to trauma. Since elevated levels of PAI-1 prior to surgery are known to predispose to deep vein thrombosis, which may form already during the operation, the effect of dextran on PAI-1 described here may explain its clot preventing properties.
Eriksson
M
M
Department of Anesthesiology and Intensive care, University Hospital, Uppsala, Sweden.
Saldeen
T
T
D000005:Abdomen / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000941:Antigens / Q000097:blood; D003911:Dextrans / Q000494:pharmacology*; D017558:Elective Surgical Procedures; D004573:Electrolytes / Q000008:administration & dosage; D005342:Fibrinolysis / Q000187:drug effects; D005947:Glucose / Q000008:administration & dosage; D006622:Hip Prosthesis; D006801:Humans; D007813:Laparotomy; D008875:Middle Aged; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood / Q000378:metabolism*; D010959:Tissue Plasminogen Activator / Q000097:blood / Q000276:immunology / Q000378:metabolism*
D000941:Antigens; D003911:Dextrans; D004573:Electrolytes; D017395:Plasminogen Activator Inhibitor 1; D010959:Tissue Plasminogen Activator; D005947:Glucose