title: [Study of a new lactic acid and pH 5.2 lactoserum emulsion for feminine hygiene. Results of a clinical study].
abstract: A new solution intended for use in feminine hygiene, and composed of a lactic acid base and of lactoserum at pH 5.2, was tested for a period of 8 weeks on 40 women. This test focused on its influence on the pH and the flora, as well as on the tolerance of the mucous membrane. Successive measurements of the vulvar and vaginal pH revealed no statistically significant variation between the beginning and the end of the trial. At the study inclusion thirty patients had a normal flora; of these, twenty-eight showed no change during the eight weeks of the trial. A candidiasis appeared in two patients in the middle of the trial; one of these patients received no treatment, while the other was given a five-day treatment due to similar occurrences in her past medical history. The product under study was continued throughout the trial, at the conclusion of which the flora was found to have returned to normal. At the study inclusion ten patients had either a candidiasis or a vaginitis. Their lack of symptoms and the absence of any previous problems resulted in no treatment being made in five of the ten cases, while in four cases the presence of such prior problems led to the immediate carrying out of short-length treatments. In every case, the product under study was used until the end of the trial. Bacteriological studies showed that in all the patients--whether or not they had been treated--the flora rapidly returned to normal.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.forename: A
authors.initials: A
authors.lastname: Jacquet
authors.forename: R
authors.initials: R
authors.lastname: Roussilhes
authors.forename: S
authors.initials: S
authors.lastname: Anoufa
authors.forename: C
authors.initials: C
authors.lastname: Marteau
authors.forename: F
authors.initials: F
authors.lastname: Mallet
authors.forename: A
authors.initials: A
authors.lastname: Audebert
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D002181:Candidiasis, Vulvovaginal / Q000139:chemically induced; D004338:Drug Combinations; D004655:Emulsions; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D006920:Hygiene; D007106:Immune Sera; D007773:Lactates / Q000008:administration & dosage* / Q000009:adverse effects; D019344:Lactic Acid; D008875:Middle Aged; D012915:Soaps / Q000008:administration & dosage*; D014621:Vagina / Q000187:drug effects* / Q000382:microbiology
chemical_list: D004338:Drug Combinations; D004655:Emulsions; D007106:Immune Sera; D007773:Lactates; D012915:Soaps; D019344:Lactic Acid; C008242:lactacyd