Low-dose ultraviolet B pretreatment of human islets reduces graft immunogenicity through the induction of antigen-presenting cell apoptosis without adversely affecting insulin secretion.
Goodman
E
E
Department of Surgery, Columbia University College of Physicians and Surgeons, New York, NY 10032.
Fiedor
P
P
Fein
S
S
Hardy
M
M
Athan
E
E
D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D001786:Blood Glucose / Q000378:metabolism; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000096:biosynthesis; D002460:Cell Line; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000628:therapy; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000628:therapy*; D004730:Endothelium, Vascular / Q000187:drug effects / Q000276:immunology / Q000528:radiation effects; D005434:Flow Cytometry; D006681:HLA-D Antigens / Q000032:analysis / Q000096:biosynthesis; D015395:Histocompatibility Antigens Class I / Q000032:analysis / Q000096:biosynthesis; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007371:Interferon-gamma / Q000494:pharmacology; D007515:Islets of Langerhans / Q000528:radiation effects*; D016381:Islets of Langerhans Transplantation / Q000276:immunology* / Q000502:physiology; D051379:Mice; D008819:Mice, Nude; D009000:Monocytes; D051381:Rats; D011923:Rats, Nude; D011994:Recombinant Proteins; D014183:Transplantation, Heterologous / Q000276:immunology* / Q000502:physiology; D014466:Ultraviolet Rays; D014471:Umbilical Veins; D019010:Vascular Cell Adhesion Molecule-1
D001786:Blood Glucose; D015815:Cell Adhesion Molecules; D006681:HLA-D Antigens; D015395:Histocompatibility Antigens Class I; D007328:Insulin; D011994:Recombinant Proteins; D019010:Vascular Cell Adhesion Molecule-1; D007371:Interferon-gamma