title: Isolation and embryonic expression of Xel-1, a nervous system-specific Xenopus gene related to the elav gene family.
abstract: We have identified a new member of the elav gene family in Xenopus laevis. This gene, Xel-1, like the other elav-related genes, encodes a putative RNA-binding protein that contains three RNA Recognition Motifs and is solely expressed in the nervous system. Xel-1 is most likely the Xenopus homologue of Hel-N1, one of the three known human genes related to elav. Xel-1 is not expressed in early neural precursors but rather in differentiating neurons of the central nervous system, as well as in the cranial and the spinal ganglion cells. Xel-1 thus appears to be an early differentiation marker for both the central and the peripheral nervous system of Xenopus laevis.
authors.affiliation: Laboratoire d'Embryologie Moléculaire et Expérimentale, URA 1134 du Centre National de la Recherche Scientifique, Université Paris XI, Orsay, France.
authors.forename: M
authors.initials: M
authors.lastname: Perron
authors.forename: L
authors.initials: L
authors.lastname: Théodore
authors.forename: M
authors.initials: M
authors.lastname: Wegnez
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers / Q000235:genetics; D018076:DNA, Complementary / Q000235:genetics; D051959:ELAV Proteins; D000067777:ELAV-Like Protein 2; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D017403:In Situ Hybridization; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009420:Nervous System / Q000196:embryology*; D016601:RNA-Binding Proteins / Q000235:genetics*; D012261:Ribonucleoproteins; D017386:Sequence Homology, Amino Acid; D029867:Xenopus Proteins; D014982:Xenopus laevis / Q000196:embryology* / Q000235:genetics*
chemical_list: D017931:DNA Primers; D018076:DNA, Complementary; D051959:ELAV Proteins; D000067777:ELAV-Like Protein 2; C480172:ELAVL1 protein, Xenopus; C086811:ELAVL2 protein, human; D009419:Nerve Tissue Proteins; D016601:RNA-Binding Proteins; D012261:Ribonucleoproteins; D029867:Xenopus Proteins