Prospectives for cutaneous malignant melanoma. Considerations of the precursor state and heritability.
Each of the discoveries through the years has begotten a series of Gordian knots. We must patiently inspect our new collection of mysteries and focus on those where our efforts may well change the course of the disease to the benefit of affected patients. The proper management of the precursor state, the beginning of the disease, and the patient exploration of the complexities of heritability would seem to be appropriate beginnings.
Clark
W H
WH
Department of Pathology, Harvard Medical School, Beth Israel Hospital, Boston, MA, USA.
Goldstein
A M
AM
Tucker
M A
MA
D004198:Disease Susceptibility; D006801:Humans; D008545:Melanoma / Q000209:etiology* / Q000235:genetics; D009362:Neoplasm Metastasis; D009506:Nevus / Q000473:pathology; D011230:Precancerous Conditions / Q000473:pathology; D011379:Prognosis; D012878:Skin Neoplasms / Q000209:etiology* / Q000235:genetics / Q000473:pathology