title: Anaplastic thyroid carcinoma producing the granulocyte colony stimulating factor (G-CSF): report of a case.
abstract: We report herein the unusual case of a 60-year-old woman with an anaplastic thyroid carcinoma which produced granulocyte colony stimulating factor (G-CSF). She presented with large neck masses, respiratory difficulty, and a high fever. Laboratory examinations revealed marked leukocytosis of 43,200/mm3 with 85% granulocytes and an elevated G-CSF level of 67 pg/dl. Total thyroidectomy with bilateral node dissection and tracheostomy was performed, and a histological diagnosis of large-cell anaplastic thyroid carcinoma was confirmed. Immunohistochemical examination with a polyclonal antibody against G-CSF stained the tumor cells. Although the respiratory difficulty, fever, and marked granulocytosis subsequently improved, she died 1 month after undergoing surgery due to metastatic mediastinal disease.
authors.affiliation: Department of Surgery (II), Kanazawa University Hospital, Kanazawa University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Iwasa
authors.forename: M
authors.initials: M
authors.lastname: Noguchi
authors.forename: K
authors.initials: K
authors.lastname: Mori
authors.forename: N
authors.initials: N
authors.lastname: Ohta
authors.forename: I
authors.initials: I
authors.lastname: Miyazaki
authors.forename: A
authors.initials: A
authors.lastname: Nonomura
authors.forename: Y
authors.initials: Y
authors.lastname: Mizukami
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: T
authors.initials: T
authors.lastname: Michigishi
mesh_terms: D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D008479:Mediastinal Neoplasms / Q000556:secondary; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy
chemical_list: D016179:Granulocyte Colony-Stimulating Factor