High-grade B-cell cerebral lymphoma in a patient with anti-myelin-associated glycoprotein IgM paraproteinemic neuropathy.
A 74-year-old woman with a sensory neuropathy and IgM M-protein monoclonal gammopathy of undetermined significance developed a fatal B-cell cerebral lymphoma. CSF protein immunofixation revealed intrathecal secretion of a paraprotein of the same heavy- and light-chain isotypes as the serum monoclonal component (IgM-lambda). Reactivation of Epstein-Barr virus was present in the lymphoma cells. Different factors may be involved in the preferential malignant development of the monoclonal B-cell clone within the CNS.
Ellie
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Department of Neurology, University Hospital of Bordeaux, France.
Vital
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Steck
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AJ
Julien
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Henry
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Vital
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D000368:Aged; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D001932:Brain Neoplasms / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D004797:Enzyme-Linked Immunosorbent Assay; D017809:Fatal Outcome; D005260:Female; D005682:Gadolinium; D019786:Gadolinium DTPA; D004854:Herpesvirus 4, Human / Q000302:isolation & purification; D006801:Humans; D007075:Immunoglobulin M / Q000097:blood*; D016393:Lymphoma, B-Cell / Q000150:complications* / Q000000981:diagnostic imaging / Q000473:pathology / Q000821:virology; D009185:Myelin Proteins / Q000276:immunology*; D018992:Myelin-Associated Glycoprotein; D009942:Organometallic Compounds; D010265:Paraproteinemias / Q000150:complications* / Q000000981:diagnostic imaging; D004369:Pentetic Acid / Q000031:analogs & derivatives; D010523:Peripheral Nervous System Diseases / Q000150:complications*; D011877:Radionuclide Imaging
D007075:Immunoglobulin M; D009185:Myelin Proteins; D018992:Myelin-Associated Glycoprotein; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA