Expression of stereotyped behaviour requires stimulation of nigral D1 dopamine receptors.
Dopamine receptors in the pars reticulata of the substantia nigra were inactivated following bilateral injections of N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ). Loss of D1, but not D2, receptors was associated with a significant decrease in the incidence of stereotyped head-down sniffing elicited by the mixed D1/D2 receptor agonist, apomorphine. The results support the hypothesis that D1 receptors in the substantia nigra are necessary for the expression of dopamine mediated stereotyped behaviour.
Lee
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CY
Department of Clinical Pharmacology, Flinders University of South Australia, Adelaide.
Double
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KL
Crocker
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AD
D000818:Animals; D000978:Antiparkinson Agents / Q000494:pharmacology; D001058:Apomorphine / Q000494:pharmacology; D001345:Autoradiography; D002375:Catalepsy / Q000139:chemically induced; D018492:Dopamine Antagonists / Q000494:pharmacology; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000819:agonists* / Q000037:antagonists & inhibitors; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D013239:Stereotyped Behavior / Q000187:drug effects*; D013268:Stimulation, Chemical; D013378:Substantia Nigra / Q000033:anatomy & histology / Q000187:drug effects*
D000978:Antiparkinson Agents; D018492:Dopamine Antagonists; D011804:Quinolines; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; C000470:EEDQ; D001058:Apomorphine