Control of coronary blood flow by autacoids.
Coronary flow and thus myocardial perfusion is regulated by myogenic, metabolic, humoral and neuro-hormonal factors which closely interact with local autacoids released from the endothelial lining of the coronary bed. In a number of disease states an impaired synthesis and release of autacoids decisively limit the overall capacity of coronary regulation and adaptation of myocardial perfusion to increased metabolic demands. The important factors for these control mechanisms are analyzed and reviewed in this article.
Bassenge
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Institut für Angewandte Physiologie Universität Freiburg, Germany.
D000594:Amino Acid Oxidoreductases / Q000378:metabolism; D000595:Amino Acid Sequence; D012898:Autacoids / Q000378:metabolism / Q000502:physiology*; D001920:Bradykinin / Q000378:metabolism; D003326:Coronary Circulation / Q000502:physiology*; D003327:Coronary Disease / Q000503:physiopathology; D016232:Endothelins / Q000096:biosynthesis / Q000502:physiology; D006801:Humans; D015289:Leukotrienes / Q000378:metabolism; D008969:Molecular Sequence Data; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase; D011453:Prostaglandins / Q000378:metabolism; D012084:Renin-Angiotensin System / Q000502:physiology; D013931:Thromboxanes / Q000378:metabolism
D012898:Autacoids; D016232:Endothelins; D015289:Leukotrienes; D011453:Prostaglandins; D013931:Thromboxanes; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D001920:Bradykinin