title: Prevalence of hepatitis B and C viruses in healthy Indonesian blood donors.
abstract: Blood samples were collected from 7572 healthy volunteer blood donors from 21 of the 27 Indonesian provinces, and tested for antibodies to hepatitis C virus (anti-HCV) using the new second-generation enzyme immunosorbent assay, and also tested for hepatitis B surface antigen (HBsAg). We detected anti-HCV in 2.1% of the blood donors. No statistically significant difference was found between males and females or between locations, but there was a statistically significant increasing likelihood of anti-HCV prevalence with increasing age. HBsAg was found in 8.8% of the 3839 tested donors. There was no statistically significant difference between sexes or age groups, but there was a statistically significant higher prevalence in the islands of Sulawesi and eastern Indonesia. Only 7 individuals, from 5 locations, were both anti-HCV and HBsAg positive. Based on responses to a questionnaire, a history of surgery, blood transfusion, intravenous medication, and acupuncture were identified as risk factors for the presence of anti-HCV. No such risk factor was identified for HBsAg prevalence. The combined data suggest separate modes of transmission for the 2 viruses, and indicate the need for continued surveillance for these agents in Indonesian blood banks.
authors.affiliation: Medical Faculty, University of Indonesia, Cipto Mangunkusumo Hospital, Jakarta.
authors.forename: H A
authors.initials: HA
authors.lastname: Sulaiman
authors.lastname: Julitasari
authors.forename: A
authors.initials: A
authors.lastname: Sie
authors.forename: M
authors.initials: M
authors.lastname: Rustam
authors.forename: W
authors.initials: W
authors.lastname: Melani
authors.forename: A
authors.initials: A
authors.lastname: Corwin
authors.forename: G B
authors.initials: GB
authors.lastname: Jennings
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D001782:Blood Donors; D002648:Child; D005260:Female; D006508:Hepatitis Antibodies / Q000032:analysis*; D006509:Hepatitis B / Q000276:immunology*; D006514:Hepatitis B Surface Antigens / Q000032:analysis*; D006526:Hepatitis C / Q000276:immunology*; D018937:Hepatitis C Antibodies; D006801:Humans; D007214:Indonesia / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D011156:Population Density; D015995:Prevalence; D012307:Risk Factors
chemical_list: D006508:Hepatitis Antibodies; D006514:Hepatitis B Surface Antigens; D018937:Hepatitis C Antibodies