Comparative study of three amniotic fluid markers in premature rupture of membranes: fetal fibronectin, alpha-fetoprotein, diamino-oxydase.
BACKGROUND
To study the comparative diagnostic value in premature rupture of membranes (PRM) of three amniotic components: fetal fibronectin (fFN), alphafetoprotein (AFP), diamino-oxydase (DAO).


METHODS
131 pregnant women took part in our prospective study. Three samples were obtained successively for each patient in a random order. Two clinical situations were studied: group A of 68 women with clinical certain PRM and group B of 63 women with a highly unlikely PRM.


RESULTS
fFN is the best marker for diagnosis of PRM (sensitivity of 94% and specificity of 97%). AFP and DAO are complementary: the NPV is greater for AFP (87% against 84%) whereas the PPV is greater for DAO (95% against 86%).


CONCLUSIONS
Apart from its value in predicting premature labor, vaginal fFN represents a diagnostic test of PRM with good specificity and sensitivity.
Gaucherand
P
P
Gynecological Obstetrical Department, Hopital de la Croix Rousse, Lyon, France.
Guibaud
S
S
Awada
A
A
Rudigoz
R C
RC
D006631:Amine Oxidase (Copper-Containing) / Q000378:metabolism*; D000653:Amniotic Fluid / Q000378:metabolism*; D015415:Biomarkers / Q000032:analysis; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005322:Premature Rupture of Fetal Membranes / Q000175:diagnosis* / Q000378:metabolism*; D005353:Fibronectins / Q000378:metabolism*; D006801:Humans; D011237:Predictive Value of Tests; D011247:Pregnancy; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D000509:alpha-Fetoproteins / Q000378:metabolism*
D015415:Biomarkers; D005353:Fibronectins; D000509:alpha-Fetoproteins; D006631:Amine Oxidase (Copper-Containing)