title: A reappraisal of serial isotope bone scans in prostate cancer.
abstract: Carcinoma of the prostate is the commonest malignancy of the genitourinary tract in the male and is frequently associated with metastatic bone disease. Serial isotope bone scans for screening secondary deposits are not cost-effective. We have evaluated the serum prostate markers prostate-specific antigen (PSA) and prostatic acid phosphatase (PAP) as an alternative to conventional serial bone scanning in 129 patients with newly diagnosed prostate cancer over a period of 3 years. Although serum PSA did not reflect local tumour burden at presentation, it was significantly elevated in those who presented with stage D disease (p < 0.01). 45 patients presented de novo with metastatic bone deposits and a further 18 patients developed metastases during the study period. The sensitivity of PSA in detecting secondary deposits at presentation for levels in excess of 100 micrograms/l was 93.75%, the positive predictive value 95.7% and the negative predictive value for levels less than 5 micrograms/l was 90.6%. During the follow-up period the sensitivity was 94.4%, the positive predictive value 100% and the negative predictive value 100%, with a median lead time of 3 months in predicting metastases in the 18 patients with progressive disease. When compared with PAP, PSA was found to be a statistically superior marker of bone metastases both at presentation and follow-up (p < 0.05). We recommend that PAP measurements are no longer necessary and should be replaced by PSA, and that serial serum PSA estimations should determine the need for future isotope bone scans in the patient with established prostate cancer.
authors.affiliation: Department of General Surgery, University College Hospital, Galway, Ireland.
authors.forename: J M
authors.initials: JM
authors.lastname: O'Donoghue
authors.forename: E
authors.initials: E
authors.lastname: Rogers
authors.forename: H
authors.initials: H
authors.lastname: Grimes
authors.forename: P
authors.initials: P
authors.lastname: McCarthy
authors.forename: M
authors.initials: M
authors.lastname: Corcoran
authors.forename: H
authors.initials: H
authors.lastname: Bredin
authors.forename: H F
authors.initials: HF
authors.lastname: Given
mesh_terms: D000135:Acid Phosphatase / Q000097:blood*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000556:secondary*; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011467:Prostate; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000473:pathology*; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013669:Technetium Tc 99m Medronate; D013997:Time Factors
chemical_list: D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen; D013669:Technetium Tc 99m Medronate