title: The effects on chronic periodontitis of a subgingivally-placed redox agent in a slow release device.
abstract: Adjunctive chemical agents can reduce the need for meticulous plaque control. The aim of this investigation was to evaluate the periodontal treatment potential of subgingival application of the redox agent methylene blue in a slow-release device. This randomized, single-blind, split-mouth study included 18 patients aged 35-57 years, with chronic adult periodontitis, pocketing of at least 5 mm and radiographic evidence of regular bone loss. All experimental sites received subgingival debridement at day 0. Test sites received 32% w/w methylene blue in the slow release device at days 0 and 28. Clinical examination and microbiological sampling were performed at days 0, 7, 28, 56 and 84. Clinical improvements were seen in both groups, but test sites showed consistently greater improvements, some of which were statistically significant (as determined by between-group comparisons utilising SNDs). Significant between-group differences in relation to baseline levels were seen in bleeding index at days 7 and 56, in probeable pocket depth at day 56 and for the Perioscan BANA test at day 7. This pilot study thus showed that adjunctive methylene blue in a slow-release device can produce greater clinical and microbiological improvements than subgingival debridement alone.
authors.affiliation: Department of Periodontology, Eastman Dental Institute for Oral and Dental Health Care Sciences, University of London, UK.
authors.forename: P C
authors.initials: PC
authors.lastname: Ower
authors.forename: M
authors.initials: M
authors.lastname: Ciantar
authors.forename: H N
authors.initials: HN
authors.lastname: Newman
authors.forename: M
authors.initials: M
authors.lastname: Wilson
authors.forename: J S
authors.initials: JS
authors.lastname: Bulman
mesh_terms: D000328:Adult; D016301:Alveolar Bone Loss / Q000188:drug therapy / Q000382:microbiology / Q000628:therapy; D000891:Anti-Infective Agents, Local / Q000008:administration & dosage / Q000627:therapeutic use*; D001439:Bacteroides / Q000187:drug effects / Q000302:isolation & purification; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D003773:Dental Plaque / Q000517:prevention & control; D004343:Drug Implants; D005881:Gingiva; D005884:Gingival Hemorrhage / Q000188:drug therapy; D006801:Humans; D008751:Methylene Blue / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D010084:Oxidation-Reduction; D010510:Periodontal Diseases / Q000188:drug therapy* / Q000382:microbiology / Q000628:therapy; D010514:Periodontal Pocket / Q000188:drug therapy; D010865:Pilot Projects; D016966:Porphyromonas gingivalis / Q000187:drug effects / Q000302:isolation & purification; D016037:Single-Blind Method; D013357:Subgingival Curettage; D014208:Treponema / Q000187:drug effects / Q000302:isolation & purification
chemical_list: D000891:Anti-Infective Agents, Local; D003692:Delayed-Action Preparations; D004343:Drug Implants; D008751:Methylene Blue