Intracellular study of substance P in human Scarpa's ganglion cells.
The effect of substance P on surgically removed human Scarpa's ganglion cells was investigated by intracellular recordings and bath application under in vitro conditions. The neuropeptide produced a slow depolarization of the membrane potential which was accompanied by an increase in membrane resistance. Furthermore, an enhanced firing in response to depolarization occurred. The results strongly support a modulatory action of the neuroactive peptide substance P on human Scarpa's ganglion cells.
Felix
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D
Division of Neurobiology, University of Berne, Switzerland.
Felix
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H
D002478:Cells, Cultured; D006801:Humans; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D013373:Substance P / Q000494:pharmacology*; D009435:Synaptic Transmission / Q000187:drug effects; D014725:Vestibular Nerve / Q000187:drug effects*
D013373:Substance P