title: Is MRI helpful in evaluating the response of cervical cancer to neoadjuvant chemotherapy?
abstract: BACKGROUND
  To assess the potential role of magnetic resonance imaging (MRI) in evaluating the response of cervical tumor to neoadjuvant chemotherapy.
  
  
  METHODS
  We studied 14 patients with locally advanced carcinoma of the cervix. MRI was performed before and after each cycle. All patients underwent laparotomy four weeks after the last cycle. MR images after chemotherapy were compared with surgical-pathologic findings.
  
  
  RESULTS
  Related to parametrial state after chemotherapy, surgical examination correlated with MRI in nine patients (nine true negative). In three cases parametrial invasion was over-estimated (three false-positive) and in two it was underestimated, so that tumor resection was not possible once laparotomy was performed (two false-negative). MRI estimation of tumor size was confirmed at pathologic examination in only eight patients, whilst it was over-estimated in the other four ones.
  
  
  CONCLUSIONS
  These initial results suggest that MRI could not be as precise for cervix cancer staging and evaluation of response to chemotherapy as has recently been postulated. This is especially important since a false negative result may induce the surgeon to perform laparotomy in error in cases of unresectable tumors.
authors.affiliation: Department of Gynecology and Obstetrics, Hospital Clinic i Provincial, University of Barcelona, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Vives
authors.forename: C
authors.initials: C
authors.lastname: Castelo-Branco
authors.forename: X
authors.initials: X
authors.lastname: Iglesias
authors.forename: X
authors.initials: X
authors.lastname: Tomás
authors.forename: H
authors.initials: H
authors.lastname: Palombo
authors.forename: J
authors.initials: J
authors.lastname: Pahisa
authors.forename: J A
authors.initials: JA
authors.lastname: Lejárcegui
authors.forename: A
authors.initials: A
authors.lastname: Salvador
authors.forename: L
authors.initials: L
authors.lastname: Puig-Tintoré
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D005188:False Negative Reactions; D005260:Female; D006801:Humans; D007044:Hysterectomy; D008279:Magnetic Resonance Imaging; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D010166:Palliative Care; D002583:Uterine Cervical Neoplasms / Q000175:diagnosis* / Q000188:drug therapy / Q000473:pathology / Q000601:surgery; D014944:World Health Organization
chemical_list: D000970:Antineoplastic Agents