Transrectal ultrasound-guided transperineal cryoablation in the treatment of prostate carcinoma: preliminary results.
OBJECTIVE
We studied ultrasound-guided percutaneous cryoablation for treatment of prostate carcinoma.


METHODS
Our series includes 83 individuals who underwent transrectal ultrasound-guided transperineal percutaneous cryoablation of the prostate. Prostate specific antigen levels, biopsy results and complications were assessed at 3 months.


RESULTS
Of 61 biopsies 8 (13.1%) were positive for carcinoma (half showed stage D disease). Of patients with stages T1 to T3 cancer 92.6% were free of disease at 3 months. Prostate specific antigen levels were significantly decreased by an average of 1.90 ng./ml. (p < 0.05). Major complications were infrequent, including bladder perforation in 1 patient, urethral strictures in 3, bladder outlet obstruction in 2 and partial incontinence in 2. Impotence was frequent but transient.


CONCLUSIONS
Transrectal ultrasound-guided transperineal percutaneous cryoablation of the prostate produces few major complications and appears at 3 months to be effective in eradicating local prostate tumors. Longer followup is required to test the original hypothesis.
Wieder
J
J
Division of Urology, University of California San Diego Medical Center, USA.
Schmidt
J D
JD
Casola
G
G
vanSonnenberg
E
E
Stainken
B F
BF
Parsons
C L
CL
D000328:Adult; D000368:Aged; D001706:Biopsy; D003452:Cryosurgery / Q000009:adverse effects / Q000379:methods*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D010502:Perineum; D011183:Postoperative Complications / Q000453:epidemiology; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000000981:diagnostic imaging / Q000473:pathology / Q000601:surgery*; D012007:Rectum; D014463:Ultrasonography
D017430:Prostate-Specific Antigen