TCR V gene usage in autoimmunity.
With the use of polymerase chain reaction technology, investigators now have the ability to assess, in a comprehensive and rapid manner, the entire repertoire of T cell antigen receptors expressed by pathogenic cells present in virtually any disease site. A summary of studies of T cell receptor variable gene usage suggests that preferential expression can be identified most reproducibly when cells are isolated directly from pathogenic lesions. This provides a framework for future investigations in other autoimmune settings.
Gold
D P
DP
San Diego Regional Cancer Center.
D000818:Animals; D001327:Autoimmune Diseases / Q000235:genetics* / Q000276:immunology; D004195:Disease Models, Animal; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000235:genetics / Q000276:immunology; D005796:Genes / Q000235:genetics*; D006801:Humans; D004676:Myelin Basic Protein / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000235:genetics* / Q000276:immunology; D018089:Superantigens / Q000276:immunology
D004676:Myelin Basic Protein; D011948:Receptors, Antigen, T-Cell; D018089:Superantigens