title: [Anaphylactic shock after lipid exchange chromatography in a patient with congenital IgA deficiency].
abstract: We report on a 59-year-old woman patient with selective IgA deficiency and familial hypercholesterinaemia. To lower elevated LDL levels in the patient's blood, immunoadsorption therapy with sheep-anti-human polyclonal antibodies coupled to sepharose columns was administered. During the procedure, the patient developed an anaphylactic shock requiring intensive care treatment. The patient's history revealed a fresh cell therapy with fetal sheep cells 10 years previously. Intracutaneous testing confirmed sensitization to sheep immunoglobulin, which was the most likely reason for the anaphylactic shock.
authors.affiliation: Hautklinik, Johannes Gutenberg Universität, Mainz.
authors.forename: A H
authors.initials: AH
authors.lastname: Enk
authors.forename: J
authors.initials: J
authors.lastname: Bauerschmitz
authors.forename: J
authors.initials: J
authors.lastname: Knop
mesh_terms: D000707:Anaphylaxis / Q000276:immunology*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000276:immunology / Q000628:therapy*; D017098:IgA Deficiency / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood; D007163:Immunosorbent Techniques; D007428:Intradermal Tests; D008875:Middle Aged
chemical_list: D008078:Cholesterol, LDL; D007073:Immunoglobulin E