title: Oral misoprostol versus vaginal gemeprost for cervical dilatation prior to vacuum aspiration in women in the sixth to twelfth week of gestation.
abstract: The effectiveness of oral misoprostol versus vaginal gemeprost for cervical dilatation prior to vacuum aspiration was compared in women in the 6th to 12th week of pregnancy. Sixty-four nulliparous women requesting termination of pregnancy between 6th to 12th weeks of gestation were randomized to receive either 400 micrograms misoprostol orally or 1 mg vaginal gemeprost at 12 hr or 3 hr prior to vacuum aspiration, respectively. The cervical dilatation at vacuum aspiration, the ease of the subsequent surgical procedure, and the incidence of complications and side effects were compared between these two methods of cervical priming. The median cervical dilatation at vacuum aspiration in the misoprostol group was significantly greater than that in the gemeprost group (8.0 mm versus 7.0 mm, p < 0.02). Preoperative side effects were significantly less frequent in the misoprostol group (p < 0.01). The ease of dilatation assessed subjectively by the operating surgeons was also improved significantly in the misoprostol group (p < 0.01). However, the duration of operation and blood loss were similar in both groups. Since misoprostol is also much cheaper and more convenient to use, we conclude that oral misoprostol is better than vaginal gemeprost for cervical dilatation prior to vacuum aspiration in first trimester pregnancy.
authors.affiliation: Department of Obstetrics and Gynaecology, University of Hong Kong, Tsan Yuk Hospital.
authors.forename: S W
authors.initials: SW
authors.lastname: Ngai
authors.forename: K C
authors.initials: KC
authors.lastname: Yeung
authors.forename: T
authors.initials: T
authors.lastname: Lao
authors.forename: P C
authors.initials: PC
authors.lastname: Ho
mesh_terms: D000020:Abortifacient Agents, Nonsteroidal / Q000008:administration & dosage / Q000494:pharmacology* / Q000592:standards; D000028:Abortion, Induced; D000282:Administration, Intravaginal; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000527:Alprostadil / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000592:standards; D002584:Cervix Uteri / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D016595:Misoprostol / Q000008:administration & dosage / Q000494:pharmacology* / Q000592:standards; D011247:Pregnancy; D011261:Pregnancy Trimester, First / Q000187:drug effects; D013396:Suction / Q000379:methods; D013997:Time Factors
chemical_list: D000020:Abortifacient Agents, Nonsteroidal; D016595:Misoprostol; C021182:gemeprost; D000527:Alprostadil