[Modification of hemorheological parameters in microvascular complications of diabetes].
The aim of the present study was to assess the possible modifications in the parameters of red cell aggregation and blood and plasma viscosity in 92 diabetic patients compared to 82 non diabetic control subjects. Based on the presence of microalbuminuria (> 30 mg/24 h) and/or retinopathy each group of diabetic patients was divided into two subgroups. This study shows increased red cell aggregation and blood viscosity among diabetic patients with microangiopathy. There was a very good correlation between fibrinogen level and the different rheological measurements. The results of this study confirm the importance of the blood rheology abnormalities observable in diabetes. These disorders increase peripheral vascular resistances and ischemia and therefore worsen diabetic nephropathy and retinopathy.
Bauduceau
B
B
Service de Diabétologie, Hôpital d'Instruction des Armées Bégin, Saint-Mandé, France.
Renaudeau
C
C
Mayaudon
H
H
Hélie
C
C
Ducorps
M
M
Sonnet
E
E
Yvert
J P
JP
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000419:Albuminuria; D001809:Blood Viscosity; D016022:Case-Control Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood*; D003928:Diabetic Nephropathies / Q000097:blood; D003930:Diabetic Retinopathy / Q000097:blood; D004903:Erythrocyte Aggregation; D005260:Female; D018056:Hemorheology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012016:Reference Values; D012044:Regression Analysis