CA 125, CA 15.3, CA 27.29, CEA, beta-hCG and alpha-fetoprotein levels in cyst fluid of breast macrocysts.
OBJECTIVE
To determine the tumoral markers CA 125, CA 15.3, CA 27.29, CEA, beta-hCG and alpha-fetoprotein in serum and breast cystic fluid in women with fibrocystic breast disease.


METHODS
The study comprised 50 women diagnosed with fibrocystic breast disease but without breast macrocysts, and 60 women with macrocysts.


RESULTS
Significantly higher levels of CA 125, CA 27.29, beta-hCG and CEA were observed in the cyst fluid than in the serum of the same patients. According to their K+/Na+ quotient we found that when K+/Na+ was < 3, cyst fluid CA 125, CA 27.29, beta-hCG and CEA levels were significantly higher than serum levels. However, when K+/Na+ was > 3, only CA 27.29 and beta-hCG levels were significantly higher. Comparing cyst fluid marker levels with respect to the K+/Na+ ratio, the only difference observed was in CA 125 which was significantly greater when K+/Na+ was < 3. A negative correlation was found between CA 125 and the K+/Na+ quotient.


CONCLUSIONS
These results suggest that CA 125 could be used as a marker to identify cyst type.
Martínez
L
L
Department of Obstetrics and Gynaecology, Regional Hospital Virgen de las Nieves, Granada, Spain.
Castilla
J A
JA
Blanco
N
N
Perán
F
F
Herruzo
A
A
D019326:17-alpha-Hydroxyprogesterone; D000293:Adolescent; D000328:Adult; D000951:Antigens, Neoplasm / Q000032:analysis*; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor / Q000032:analysis*; D001707:Biopsy, Needle; D018394:CA-125 Antigen / Q000032:analysis*; D002272:Carcinoembryonic Antigen / Q000032:analysis*; D006063:Chorionic Gonadotropin / Q000032:analysis*; D018997:Chorionic Gonadotropin, beta Subunit, Human; D003687:Dehydroepiandrosterone / Q000031:analogs & derivatives / Q000032:analysis; D019314:Dehydroepiandrosterone Sulfate; D004958:Estradiol / Q000032:analysis; D005122:Exudates and Transudates / Q000737:chemistry; D005260:Female; D005348:Fibrocystic Breast Disease / Q000737:chemistry* / Q000473:pathology; D006801:Humans; D006908:Hydroxyprogesterones / Q000032:analysis; D008875:Middle Aged; D018396:Mucin-1 / Q000032:analysis*; D010446:Peptide Fragments / Q000032:analysis*; D011188:Potassium / Q000032:analysis; D011374:Progesterone / Q000032:analysis; D012044:Regression Analysis; D012964:Sodium / Q000032:analysis; D013739:Testosterone / Q000032:analysis; D000509:alpha-Fetoproteins / Q000032:analysis*
D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C090797:CA 27-29 antigen; D018394:CA-125 Antigen; D002272:Carcinoembryonic Antigen; D006063:Chorionic Gonadotropin; D018997:Chorionic Gonadotropin, beta Subunit, Human; D006908:Hydroxyprogesterones; D018396:Mucin-1; D010446:Peptide Fragments; D000509:alpha-Fetoproteins; D013739:Testosterone; D003687:Dehydroepiandrosterone; D011374:Progesterone; D004958:Estradiol; D019314:Dehydroepiandrosterone Sulfate; D019326:17-alpha-Hydroxyprogesterone; D012964:Sodium; D011188:Potassium