title: The influence of prostacyclin (PGI2) on contractile properties of isolated right ventricle of rat heart.
abstract: The mechanism of the positive inotropic effect of prostacyclin (PGI2) (2.6 x 10(-6) mol/l) on the isolated right ventricle of rat heart was studied. Our results show that the positive inotropic effect of prostacyclin is produced indirectly through beta adrenoceptors and slow Ca2+ channels, because blockade of slow Ca2+ channels with verapamil (10(-6) mol/l) and beta adrenoceptors with propranolol (10(-6) mol/l) abolishes this effect. Alpha adrenoceptors do not mediate the action of PGI2.
authors.affiliation: Institute of Physiology, Faculty of Medicine, University of Belgrade, Yugoslavia.
authors.forename: M
authors.initials: M
authors.lastname: Pavlović
authors.forename: D
authors.initials: D
authors.lastname: Petković
authors.forename: M
authors.initials: M
authors.lastname: Cvetković
authors.forename: D J
authors.initials: DJ
authors.lastname: Macut
authors.forename: K
authors.initials: K
authors.lastname: Zdjelar
authors.forename: M
authors.initials: M
authors.lastname: Nesić
authors.forename: O
authors.initials: O
authors.lastname: Bosnić
authors.forename: R
authors.initials: R
authors.lastname: Radulović
authors.forename: M
authors.initials: M
authors.lastname: Mihajlović
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology*; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D011224:Prazosin / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014665:Vasodilator Agents; D014700:Verapamil / Q000494:pharmacology
chemical_list: D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D014665:Vasodilator Agents; D011433:Propranolol; D014700:Verapamil; D011464:Epoprostenol; D011224:Prazosin