[The effect of the pleiotropic action of single-locus (pp) and dual-locus (aapp) mutation of mink fur color genes on serotonin metabolism in the brain].
Specific features of serotonin (5-hydroxytryptamine, 5-HT) metabolism were studied in the brain of mutant sapphire minks, homozygous at genes determining silver-blue and Aleutian fur color (ppaa), and silver-blue minks (pp) in comparison with the standard-colored minks (++/++). In the midbrain of sapphire mutants, the activities of tryptophan hydroxylase (TPH) and monoamine oxidase (MAO), key enzymes of 5-HT biosynthesis and catabolism, were significantly higher; an increase in the 5-HT level was statistically nonsignificant due to considerable variation in this parameter; and the level of 5-hydroxyindole-3-acetic acid remained unchanged. A similar increase in TPH and MAO activities was also found in the midbrain of silver-blue pp minks, suggesting that activation of key enzymes of 5-HT metabolism in sapphire aapp minks is associated with the mutant alleles pp.
Popova
N K
NK
Voĭtenko
N N
NN
Kulikov
A V
AV
Nikulina
E M
EM
Vishnevetskaia
G B
GB
Trapezov
O V
OV
D000818:Animals; D001921:Brain / Q000201:enzymology / Q000378:metabolism*; D002874:Chromosome Mapping; D005838:Genotype; D006200:Hair Color / Q000235:genetics*; D006720:Homozygote; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D008907:Mink / Q000235:genetics* / Q000378:metabolism; D008995:Monoamine Oxidase / Q000378:metabolism; D009154:Mutation; D012701:Serotonin / Q000378:metabolism*; D014365:Tryptophan Hydroxylase / Q000378:metabolism
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014365:Tryptophan Hydroxylase; D008995:Monoamine Oxidase