Relationships among in vitro mutagenicity assays: quantitative vs. qualitative test results.
In previous investigations, we studied the relationships between the profiles of the qualitative responses of in vitro short-term tests (mutation in Salmonella typhimurium, chromosomal aberrations in CHO cells, sister chromatid exchanges in CHO cells, and mutation in mouse lymphoma cells) and common sets of chemicals. In this paper, we address the study of the quantitative responses (potency). We show that two analyses point to similar patterns of relationships: the mutation in mouse lymphoma cells assay is most similar to the CHO sister chromatid exchange assay, and the Salmonella assay is most similar to the CHO chromosomal aberrations assay.
Benigni
R
R
Laboratory of Comparative Toxicology and Ecotoxicology, Istituto Superiore di Sanità, Rome, Italy.
Andreoli
C
C
Giuliani
A
A
D000704:Analysis of Variance; D000818:Animals; D016466:CHO Cells / Q000166:cytology; D002869:Chromosome Aberrations / Q000235:genetics; D016000:Cluster Analysis; D006224:Cricetinae; D008223:Lymphoma / Q000473:pathology; D051379:Mice; D009152:Mutagenicity Tests / Q000592:standards; D009153:Mutagens / Q000633:toxicity; D009154:Mutation / Q000235:genetics*; D012486:Salmonella typhimurium / Q000235:genetics; D012854:Sister Chromatid Exchange / Q000235:genetics; D013045:Species Specificity; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D009153:Mutagens