title: Acylated triterpene saponins from Silene jenisseensis.
abstract: From the roots of Silene jenisseensis a new trans-p-methoxycinnamoyl triterpene saponin has been isolated along with its cis-p-methoxycinnamoyl isomer as an inseparable mixture. Their structures were established by chemical means and spectroscopic methods including 1D- and 2D-homonuclear and heteronuclear correlation NMR spectroscopy as 3-O-[beta-D-galactopyranosyl-(1 --> 2)-beta-D-glucuronopyranosyl]-28-O-[beta-D-glucopyranosyl-(1 --> 2)-alpha-L-rhamnopyranosyl- (1 --> 2)-beta-D-4-O-trans-p-methoxycinnamoyl-fucopyranosyl] quillaic acid and its cis-isomer, respectively. They did not show any activity in the in vitro chemoluminescence granulocytes assay, but exhibited only a weak inhibitory effect in the cyclooxygenase inhibition assay.
authors.affiliation: Laboratoire de Pharmacognosie, Faculté de Pharmacie, Université de Bourgogne, Dijon, France.
authors.forename: M A
authors.initials: MA
authors.lastname: Lacaille-Dubois
authors.forename: B
authors.initials: B
authors.lastname: Hanquet
authors.forename: Z H
authors.initials: ZH
authors.lastname: Cui
authors.forename: Z C
authors.initials: ZC
authors.lastname: Lou
authors.forename: H
authors.initials: H
authors.lastname: Wagner
mesh_terms: D000215:Acylation; D002236:Carbohydrate Conformation; D002240:Carbohydrate Sequence; D006098:Granulocytes / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008163:Luminescent Measurements; D009682:Magnetic Resonance Spectroscopy; D008516:Medicine, Chinese Traditional; D008969:Molecular Sequence Data; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D018517:Plant Roots; D010946:Plants, Medicinal; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D012503:Saponins; D014315:Triterpenes; D009828:Oleanolic Acid