[The polyethylene oxide correction of the hemodynamic sequelae in the infusion therapy of massive blood loss].
High molecular weight polyethylene oxides (2 x 10(6), 4 x 10(6), and 6 x 10(6)) were tested for their effects on blood pressure, cerebral circulation in rats with massive hemorrhage and turbulent blood flow velocity in the pre- and posthemorrhagic and polyglucine posttreatment. Polyethylene oxide (4 x 10(6) and 6 x 10(6)) alleviated hypotension and cerebral hypoperfusion, which appeared 0.5-1 hour after polyglucine therapy and increased turbulent blood flow velocity. Polyethylene oxide failed to affect spontaneous and alcian blue-induced red blood cell aggregation.
Chernysheva
G A
GA
Novikova
L K
LK
Plotnikov
M B
MB
D000208:Acute Disease; D000818:Animals; D002478:Cells, Cultured; D003911:Dextrans / Q000008:administration & dosage; D004353:Drug Evaluation, Preclinical; D004903:Erythrocyte Aggregation / Q000187:drug effects; D005440:Fluid Therapy; D006439:Hemodynamics / Q000187:drug effects; D006470:Hemorrhage / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D003911:Dextrans; D011092:Polyethylene Glycols