title: Dendritic development in normal lumbar motoneurons and following neonatal nerve crush in the rat.
abstract: Motoneurons from the rat were retrogradely labelled with cholera toxin-horseradish peroxidase at intervals during normal postnatal development and following nerve crush at birth. Normal cells displayed a relatively steady increase in total visible dendritic density which was largely confined to the dorsomedial direction. After nerve crush at birth, dorsomedially orientated dendrites failed to achieve normal density, resulting in a significantly smaller dendritic tree by adulthood. There was also a transient, abnormal extension of dendrites in the medioventral direction which had regressed to normal levels by maturity. The predominance of changes in the dorsally directed region of the dendritic tree suggests that dendritic development of motoneurons is influenced by synaptic inputs in the dorsal horn.
authors.affiliation: Department of Anatomy and Cell Biology, St. Mary's Hospital Medical School, Imperial College, London, UK.
authors.forename: G M
authors.initials: GM
authors.lastname: O'Hanlon
authors.forename: M B
authors.initials: MB
authors.lastname: Lowrie
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn; D001370:Axonal Transport; D003712:Dendrites / Q000502:physiology* / Q000648:ultrastructure; D009046:Motor Neurons / Q000166:cytology / Q000502:physiology*; D009409:Nerve Crush; D010543:Peroneal Nerve / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D013116:Spinal Cord / Q000166:cytology / Q000502:physiology*