title: The neuroanatomical specificity of ethanol action on ligand-gated ion channels: a hypothesis.
abstract: The studies described will demonstrate that the subunit composition of a GABAA receptor allows ethanol to enhance responses to GABA. Since we have determined that ethanol will influence responses to glycine, nicotine and NMDA in some, but not all, neurons with receptors to these agonists, we hypothesize that specific receptor subtypes of these ligand-gated ion channels will be affected by ethanol.
authors.affiliation: Brain and Development Research Center, University of North Carolina at Chapel Hill 27599, USA.
authors.forename: G R
authors.initials: GR
authors.lastname: Breese
authors.forename: A L
authors.initials: AL
authors.lastname: Morrow
authors.forename: P E
authors.initials: PE
authors.lastname: Simson
authors.forename: H E
authors.initials: HE
authors.lastname: Criswell
authors.forename: T J
authors.initials: TJ
authors.lastname: McCown
authors.forename: G E
authors.initials: GE
authors.lastname: Duncan
authors.forename: W J
authors.initials: WJ
authors.lastname: Keir
mesh_terms: D000818:Animals; D001921:Brain / Q000033:anatomy & histology / Q000187:drug effects* / Q000378:metabolism; D000431:Ethanol / Q000633:toxicity*; D005998:Glycine / Q000494:pharmacology; D006801:Humans; D007473:Ion Channels / Q000187:drug effects* / Q000378:metabolism; D008024:Ligands; D008959:Models, Neurological; D009118:Muscimol / Q000494:pharmacology; D016202:N-Methylaspartate / Q000494:pharmacology; D009538:Nicotine / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects / Q000378:metabolism; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology
chemical_list: D007473:Ion Channels; D008024:Ligands; D011963:Receptors, GABA-A; D009118:Muscimol; D000431:Ethanol; D005680:gamma-Aminobutyric Acid; D016202:N-Methylaspartate; D009538:Nicotine; D005998:Glycine