The intricacies of beta-globin gene expression.
Gene expression is an extremely complicated process in which several mechanisms are involved. Owing to its developmental and tissue-specific expression, the beta-globin gene is an excellent model for studying gene expression. beta-Globin gene expression involves an interplay between several different mechanisms. Chromatin structure is thought to be altered by the locus control region (LCR) located far upstream of the beta-globin gene locus. As well, multiple transcription factors come into play both in the LCR and in the individual promoters and enhancers of the beta-globin genes. The interaction between these then allows for delicate regulation of beta-globin gene expression. In the following review the elaborate system of beta-globin gene expression will briefly be examined.
Andrin
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Department of Biochemistry, University of Alberta, Edmonton, Canada.
Spencer
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D001609:Beta-Globulins / Q000235:genetics*; D002843:Chromatin / Q000737:chemistry / Q000502:physiology; D005786:Gene Expression Regulation; D006801:Humans; D008957:Models, Genetic; D012045:Regulatory Sequences, Nucleic Acid; D014157:Transcription Factors / Q000502:physiology
D001609:Beta-Globulins; D002843:Chromatin; D014157:Transcription Factors