title: Stroke and hypertension. Antihypertensive therapy withdrawal.
abstract: The effect of antihypertensive therapy withdrawal in acute ischaemic stroke patients was assessed in order to establish possible correlations between blood pressure values and the modified Rankin Scale (mRS) outcome. One hundred and twelve consecutive patients with acute ischaemic stroke and hypertension were treated with relatively similar regimen. Seventy-two hours following the onset of stroke, systolic blood pressure decreased to < or = 180 mmHg in 110 patients. Antihypertensive therapy was randomly discontinued in 59 patients. Clinical outcome and mortality were compared in patients with and without antihypertensive therapy withdrawal, no statistically significant differences (p > 0.05) between the two groups being found. Statistically significant positive correlations (p < 0.05) between mRS outcome and the decrease of systolic and diastolic blood pressure values were in patients treated with anticoagulant and antihypertensive therapy. Statistically significant negative correlations (p < 0.05) between mRS outcome and low levels of diastolic blood pressure were noted in patients who discontinued antihypertensive therapy. Our findings emphasize the need to associate antihypertensive and anticoagulant therapy in acute ischaemic stroke patients with hypertension. Spontaneous decrease of diastolic blood pressure values showed poor outcome. The management of hypertension associated with acute ischaemic stroke should be reconsidered.
authors.affiliation: Institute of Neurology and Psychiatry, Bucharest, Romania.
authors.forename: G
authors.initials: G
authors.lastname: Popa
authors.forename: V
authors.initials: V
authors.lastname: Voiculescu
authors.forename: C
authors.initials: C
authors.lastname: Popa
authors.forename: A
authors.initials: A
authors.lastname: Stănescu
authors.forename: A
authors.initials: A
authors.lastname: Nistorescu
authors.forename: I
authors.initials: I
authors.lastname: Jipescu
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000627:therapeutic use; D001794:Blood Pressure / Q000187:drug effects; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000401:mortality; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D011379:Prognosis; D013375:Substance Withdrawal Syndrome / Q000209:etiology*; D015996:Survival Rate
chemical_list: D000959:Antihypertensive Agents