title: The effect on blood pressure of a monophasic oral contraceptive containing ethinylestradiol and gestodene.
abstract: To obtain an overview of the effect of monophasic gestodene on blood pressure and to determine the frequency of "OC elevated BP/hypertension," the results of blood pressure monitoring from four clinical studies of contraceptive efficacy and safety have been retrospectively analyzed. A total of 1930 women took part in the studies, which recorded BP for up to 24 cycles. Analysis of results revealed that 97 women (5.0%) showed an increase in blood pressure from previously normal to elevated values while taking monophasic gestodene, with only 26 (1.35%) fulfilling the criteria of "OC elevated BP/hypertension." Only four women dropped out of the trials due to hypertensive blood pressure values, while 67 women (3.5%) experienced a normalization of previously elevated blood pressure measurements. In conclusion, this analysis has confirmed that gestodene has a negligible effect on blood pressure, with increased BP a relatively rare event.
authors.affiliation: Schering AG, Berlin, Germany.
authors.forename: N
authors.initials: N
authors.lastname: Fuchs
authors.forename: B
authors.initials: B
authors.lastname: Düsterberg
authors.forename: F
authors.initials: F
authors.lastname: Weber-Diehl
authors.forename: B
authors.initials: B
authors.lastname: Mühe
mesh_terms: D000293:Adolescent; D000328:Adult; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D002986:Clinical Trials as Topic; D003276:Contraceptives, Oral / Q000009:adverse effects / Q000494:pharmacology* / Q000592:standards; D003277:Contraceptives, Oral, Combined / Q000009:adverse effects / Q000494:pharmacology* / Q000592:standards; D045166:Estradiol Congeners / Q000009:adverse effects / Q000494:pharmacology* / Q000592:standards; D004997:Ethinyl Estradiol / Q000009:adverse effects / Q000494:pharmacology* / Q000592:standards; D005260:Female; D006801:Humans; D006973:Hypertension / Q000139:chemically induced; D008875:Middle Aged; D009652:Norpregnenes / Q000009:adverse effects / Q000494:pharmacology* / Q000592:standards; D012189:Retrospective Studies
chemical_list: D003276:Contraceptives, Oral; D003277:Contraceptives, Oral, Combined; D045166:Estradiol Congeners; D009652:Norpregnenes; C033273:Gestodene; D004997:Ethinyl Estradiol