Immunocytochemical evidence for a mitochondrially located nitric oxide synthase in brain and liver.
In this article we demonstrate the immunocytochemical localization of nitric oxide synthase in non-synaptosomal rat brain mitochondria and rat liver mitochondria, using a monoclonal antibody directed against the endothelial form of nitric oxide synthase. The possibility that nitric oxide synthase located in mitochondria is involved in the regulation of mitochondrial oxidative phosphorylation is discussed.
Bates
T E
TE
Department of Neurochemistry, University of London, Queen Square, England.
Loesch
A
A
Burnstock
G
G
Clark
J B
JB
D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000201:enzymology* / Q000648:ultrastructure; D002118:Calcium / Q000378:metabolism; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D008928:Mitochondria / Q000201:enzymology* / Q000648:ultrastructure; D008930:Mitochondria, Liver / Q000201:enzymology* / Q000648:ultrastructure; D019001:Nitric Oxide Synthase; D010100:Oxygen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D010100:Oxygen; D002118:Calcium