A novel BoLA class II molecule with a tissue distribution different from BoLA-DR or BoLA-DQ molecules.
This study was designed to investigate the lymphoid tissue distribution of a new BoLA class II molecule defined by a unique monoclonal antibody H42A. We immunostained various lymphoid organs of 4-month-old Holstein calves with this monoclonal antibody and compared its tissue distribution to the BoLA-DR and BoLA-DQ expressions. Our results demonstrate a unique tissue distribution of the H42A-defined molecules, restricted to epithelial cells of the thymic medulla but extending in the periphery to the different cells involved in antigen presentation (B-cells, macrophages and dendritic cells). The peculiar distribution of this new BoLA class II molecule suggests that it has a specific function.
Ababou
A
A
URA-INRA d'immuno-pathologie cellulaire et moléculaire, Maisons-Alfort, France.
Féménia
F
F
Crespeau
F
F
Fontaine
J J
JJ
Davis
W C
WC
Lévy
D
D
D000818:Animals; D000906:Antibodies / Q000032:analysis; D002417:Cattle / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000032:analysis*; D007124:Immunoenzyme Techniques / Q000662:veterinary; D008221:Lymphoid Tissue / Q000276:immunology*; D014018:Tissue Distribution
D000906:Antibodies; D000949:Histocompatibility Antigens Class II