Cytokine production and requirements during T-cell development.
Cytokines have been presumed to play an important role during T-cell development, but until recently formal proof has been missing. Most cytokine-knockout mice show apparently normal intrathymic T-cell development. The exception to this is IL-7, as both IL-7 and IL-7R alpha knockout mice show abnormally low thymic cellularity, making IL-7 the first cytokine shown to be necessary for normal intrathymic T-cell development.
Zlotnik
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Immunology Department, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304-1104, USA.
Moore
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D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism*
D016207:Cytokines