title: Granulocyte-macrophage colony-stimulating factor as adjunct therapy in relapsed lymphoid malignancy: implications for economic analyses of phase III clinical trials.
abstract: With the increasing concern over the high cost of health care, policy makers have incorporated economic analyses into phase III clinical trials as the randomized clinical trials can provide important information on the efficacy and potential cost-effectiveness of new pharmaceutical agents. Economic analyses of single-hospital experience during phase III trials of granulocyte-macrophage colony-stimulating factor (GM-CSF) as adjunct therapy for high dose chemotherapy with autologous stem cell support found significant shortening of neutropenia with GM-CSF at each hospital, but shortened hospitalization (and lower costs) at only two of three hospitals. In this study, we added data from three additional hospitals and found that the 103 patients who received GM-CSF had, on average, 5.7 days shorter durations of severe neutropenia than the 95 patients who received placebo (p < 0.0001) and 3.4 days shorter in hospitalization (p = 0.06). However, the duration of hospitalization, the primary determinant of health care costs, was shorter for GM-CSF patients in only four of the six centers and the duration of hospitalization of placebo patients was shorter at the other two centers. Careful analyses must be carried out when phase III clinical trial results are used to derive estimates of cost-effectiveness of new pharmaceutical agents. The interpretation of economic analyses of phase III clinical trials raises issues related to the perspective of the investigators, study design, collection of data on resource utilization, learning curve effects and generalizability of the results to other settings.
authors.affiliation: Lakeside Veterans Affairs Hospital, Chicago, Illinois, USA.
authors.forename: C L
authors.initials: CL
authors.lastname: Bennett
authors.forename: S L
authors.initials: SL
authors.lastname: George
authors.forename: J M
authors.initials: JM
authors.lastname: Vose
authors.forename: J J
authors.initials: JJ
authors.lastname: Nemunaitis
authors.forename: J L
authors.initials: JL
authors.lastname: Armitage
authors.forename: J O
authors.initials: JO
authors.lastname: Armitage
authors.forename: N C
authors.initials: NC
authors.lastname: Gorin
authors.forename: S C
authors.initials: SC
authors.lastname: Gulati
mesh_terms: D000970:Antineoplastic Agents / Q000627:therapeutic use; D016026:Bone Marrow Transplantation; D017326:Clinical Trials, Phase III as Topic / Q000191:economics* / Q000706:statistics & numerical data; D003131:Combined Modality Therapy; D003362:Cost-Benefit Analysis; D004311:Double-Blind Method; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000191:economics* / Q000627:therapeutic use*; D006801:Humans; D008223:Lymphoma / Q000628:therapy*; D016032:Randomized Controlled Trials as Topic / Q000191:economics* / Q000706:statistics & numerical data; D012008:Recurrence
chemical_list: D000970:Antineoplastic Agents; D016178:Granulocyte-Macrophage Colony-Stimulating Factor