Non-intercalative and sequence-selective interaction of nitropyrene/acridine-skeleton with nucleotides: application of the dextran-coupling method.
Water-insoluble typical intercalators, acridine and pyrene, were converted to water-soluble species, Dex-Pyr and Dex-Acr, respectively, by coupling with dextran polymer. By the use of these dextran-coupled intercalators, interactions of acridine- and pyrene-skeletones with various nucleotides in aqueous solutions were analyzed.
Shichita
M
M
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Shimazawa
R
R
Nakajima
O
O
Mizoguchi
H
H
Hashimoto
Y
Y
Iwasaki
S
S
D000166:Acridines / Q000737:chemistry*; D001483:Base Sequence; D003911:Dextrans / Q000737:chemistry*; D007364:Intercalating Agents / Q000737:chemistry*; D008969:Molecular Sequence Data; D009711:Nucleotides / Q000737:chemistry*; D011721:Pyrenes / Q000737:chemistry*; D014462:Ultrafiltration
D000166:Acridines; D003911:Dextrans; D007364:Intercalating Agents; D009711:Nucleotides; D011721:Pyrenes; C032668:1-nitropyrene