Longitudinal immunological follow-up of HIV infected haemophiliacs in Hungary.
Twenty-five haemophiliacs who had been infected with HIV in 1982 or 1983 were followed up from 1986 to 1993. The absolute number of the CD4+ and CD8+ cells, neopterin levels and more recently the percentage of activated, DR+ T lymphocytes were determined twice a year. In most patients a permanent decline in the CD4+ cell count was observed whereas in two HIV-infected haemophiliacs the absolute number of CD4+ cells did not change during the observation period. In these long-term non-progressor patients no clinical symptoms and no increased neopterin levels were observed. T cells subset and neopterin measurements were found to predict the development of AIDS. AIDS developed only in those patients who exhibited both a CD4+ cell count of < 350/microliter and a serum neopterin concentration of > 20 nmol/l. A negative correlation was observed between the percentage of activated. DR+ T lymphocytes and the CD4+ cell counts.
Ujhelyi
E
E
National Institute of Haematology, Blood Transfusion and Immunology, Budapest, Hungary.
Králl
G
G
Zimonyl
I
I
Bánhegyi
D
D
Hollán
S R
SR
Horváth
A
A
Fuchs
D
D
Wachter
H
H
Berkessy
E
E
Füst
G
G
D000293:Adolescent; D000328:Adult; D001708:Biopterins / Q000031:analogs & derivatives / Q000096:biosynthesis; D017252:CD3 Complex / Q000096:biosynthesis; D016516:CD4-CD8 Ratio; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D005500:Follow-Up Studies; D018023:HIV Seronegativity / Q000276:immunology; D006679:HIV Seropositivity / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D006467:Hemophilia A / Q000150:complications / Q000276:immunology* / Q000378:metabolism; D006801:Humans; D006814:Hungary; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets / Q000276:immunology; D008875:Middle Aged; D019798:Neopterin; D011237:Predictive Value of Tests
D017252:CD3 Complex; D001708:Biopterins; D019798:Neopterin