[Photosensitization of dicoumarol on tumor cells and enhancement by sodium diethyldithiocarbamate].
OBJECTIVE
To study the photosensitization of dicoumarol (Dic) on tumor cells and any effect by sodium diethyldithiocarbamate (DDC).


RESULTS
Dic, 40, 80, 120 mumol.L-1 concentration-dependently inhibited the DNA synthesis (81%-93%) and increased the mortality (50%-70.4%) of ascitic hepatoma (Hep A) cells exposed in light. These 2 indices were changed slightly by Dic alone even in non-illuminating group. DDC enhanced the photosensitization of Dic group.


CONCLUSIONS
Photosensitization of Dic showed strong antitumor activities against Hep A cells. The mortality of Hep A and inhibition of the DNA synthesis in Dic-DDC-light group significantly stronger than in Dic-light group. Photosensitization of Dic was not due to 1O2 and OH., but closely related to O2.- and H2O2.
Zhou
X F
XF
Department of Biology, Lanzhou University, China.
Yang
X W
XW
Zheng
R L
RL
D000818:Animals; D004273:DNA, Neoplasm / Q000096:biosynthesis; D001728:Dicumarol / Q000494:pharmacology*; D004050:Ditiocarb / Q000494:pharmacology*; D004357:Drug Synergism; D008027:Light; D008114:Liver Neoplasms, Experimental / Q000473:pathology; D051379:Mice; D017319:Photosensitizing Agents / Q000494:pharmacology*; D014407:Tumor Cells, Cultured / Q000187:drug effects
D004273:DNA, Neoplasm; D017319:Photosensitizing Agents; D001728:Dicumarol; D004050:Ditiocarb