title: Priming with interferon-alpha 1 or interferon-alpha 2 enhances the production of both subtypes simultaneously.
abstract: A short period of incubation with interferon-alpha ("priming") increases the amounts of IFN-alpha formed by human peripheral blood leukocytes when subsequently induced with a virus. We investigated specifically the effect of priming on the production of two individual subtypes, IFN-alpha 1 and IFN-alpha 2. The rate of interferon synthesis and the amounts formed were equally potentiated in leukocytes primed with either IFN-alpha 1 or IFN-alpha 2. Whichever of these was used for priming had no selective effect on the relative increased production of IFN-alpha 1 or IFN-alpha 2.
authors.affiliation: Institute of Virology, Slovak Academy of Sciences, Bratislava.
authors.forename: N
authors.initials: N
authors.lastname: Fuchsberger
authors.forename: G
authors.initials: G
authors.lastname: Karayianni-Vasconcelos
authors.forename: H L
authors.initials: HL
authors.lastname: Kauppinen
authors.forename: V
authors.initials: V
authors.lastname: Hajnicka
authors.forename: P
authors.initials: P
authors.lastname: Kontsek
mesh_terms: D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D000998:Antiviral Agents / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D016898:Interferon-alpha / Q000096:biosynthesis / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D000998:Antiviral Agents; D016898:Interferon-alpha