title: Opioid peptides content in the rat brain during the ictal phase and after pentylenetetrazol-kindled rats.
abstract: We determine the opioid peptide content in the rat brain during the ictal phase and postictal depression after pentylenetetrazol kindling rats. Radioimmunoassays with highly specific antisera risen for Met-enkephalin, Leu-enkephalin and octapeptide, were carried out during the ictal phase, and 15, 30 and 60 min after seizures. We always found an initial IR-Met-enkephalin decrease during the postictal depression content, followed by a reduction in IR-Leu-enkephalin and IR-octapeptide tissular concentration. We suggest a functional and differential release of the opioid peptides, during the postictal depression time-course.
authors.affiliation: Laboratorio de Análisis Químicos, Instituto Mexicano de Psiquiatría, Mexico, D.F. Mexico.
authors.forename: M
authors.initials: M
authors.lastname: Asai
authors.forename: G
authors.initials: G
authors.lastname: Matamoros-Trejo
authors.forename: E
authors.initials: E
authors.lastname: Talavera
authors.forename: A
authors.initials: A
authors.lastname: Cano-Martínez
authors.forename: M E
authors.initials: ME
authors.lastname: Avila
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D004723:Endorphins / Q000378:metabolism*; D004743:Enkephalin, Leucine / Q000378:metabolism; D004744:Enkephalin, Methionine / Q000378:metabolism; D007696:Kindling, Neurologic; D008297:Male; D010433:Pentylenetetrazole; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D013997:Time Factors; D014018:Tissue Distribution
chemical_list: D004723:Endorphins; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D010433:Pentylenetetrazole