Controlled delivery of taxol from microspheres composed of a blend of ethylene-vinyl acetate copolymer and poly (d,l-lactic acid).
'Large' (30-100 microns) and 'small' (10-30 microns) size range taxol-loaded microspheres composed of a blend of biodegradable poly (d,l-lactic acid) (PLA) polymer and nondegradable ethylene-vinyl acetate (EVA) copolymer were prepared using the solvent evaporation method. Encapsulation efficiencies were between 95-100% for taxol in 50:50 EVA:PLA blend microspheres. Between 10-13% of the total taxol content of the microspheres (0.6% w/v taxol loading) was released in 50 days. Using the chick chorioallantoic membrane (CAM) model, the taxol microspheres released sufficient taxol to produce vascular regression and inhibition of angiogenesis. This taxol-loaded microsphere formulation may have potential for the targeted delivery of taxol to a tumor via arterial chemoembolization.
Burt
H M
HM
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Jackson
J K
JK
Bains
S K
SK
Liggins
R T
RT
Oktaba
A M
AM
Arsenault
A L
AL
Hunter
W L
WL
D000818:Animals; D002642:Chick Embryo; D003692:Delayed-Action Preparations / Q000737:chemistry*; D066298:In Vitro Techniques; D007773:Lactates / Q000737:chemistry; D019344:Lactic Acid; D008855:Microscopy, Electron, Scanning; D008863:Microspheres; D009389:Neovascularization, Pathologic; D017239:Paclitaxel / Q000008:administration & dosage*; D011108:Polymers; D011145:Polyvinyls / Q000737:chemistry
D003692:Delayed-Action Preparations; D007773:Lactates; D011108:Polymers; D011145:Polyvinyls; C016438:ethylenevinylacetate copolymer; D019344:Lactic Acid; D017239:Paclitaxel