Peritonsillar infiltration with low-dose tenoxicam after tonsillectomy.
We have compared the effect of peritonsillar infiltration with tenoxicam 5 mg and placebo on postoperative pain after tonsillectomy. Fifty patients undergoing bilateral elective tonsillectomy under general anaesthesia were allocated randomly to receive peritonsillar infiltration with tenoxicam 5 mg in 8 ml of normal saline (4 ml per tonsil) or normal saline only, before tracheal extubation. Median time to first request for morphine (30 min in each group, P = 0.83), cumulative morphine requirements from 0 to 2 h after surgery (two and one doses, P = 0.50), and from 2 to 24 h after surgery (one dose in each group, P = 0.17) were similar. There were no significant differences between groups in VAS scores at rest or when drinking 100 ml of water at any time. The power of detecting a reduction in VAS scores of 20 mm was 90% at the 5% significance level.
Knudsen
K E
KE
Department of Anaesthesiology, Bispebjerg University Hospital, Copenhagen, Denmark.
Brofeldt
S
S
Mikkelsen
S
S
Bille
M
M
Brennum
J
J
Dahl
J B
JB
D000293:Adolescent; D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage*; D004311:Double-Blind Method; D004326:Drinking; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008297:Male; D010147:Pain Measurement; D010149:Postoperative Pain / Q000517:prevention & control*; D010894:Piroxicam / Q000008:administration & dosage / Q000031:analogs & derivatives*; D013997:Time Factors; D014068:Tonsillectomy
D000894:Anti-Inflammatory Agents, Non-Steroidal; D010894:Piroxicam; C032801:tenoxicam