Treatment of nonregenerative anemia with human gamma-globulin in dogs.
Five dogs with nonregenerative anemia were treated with human immunoglobulin as a 12-hour IV infusion, at dosages ranging from 0.5 to 1.5 g/kg of body weight. All dogs had a rapid response to treatment, with reticulocytosis within 1 to 4 days and a substantial increase in hematocrit within 3 to 8 days of treatment. In 2 of 5 dogs, the hematocrit returned to values within reference range and remained in the reference range for 8 to 14 months after treatment, despite discontinuing or tapering prednisone treatment to a low dose. In 3 of 5 dogs, the hematocrit did not return to the reference range. In 1 of these 3 dogs, the hematocrit remained at the new, increased value (26 to 28%) for 248 days after treatment, at which time the dog was euthanatized. In the other 2 dogs, the hematocrit had decreased to pretreatment values by 52 days after treatment. Retreatment of these 2 dogs resulted in a similar, but blunted, response to human immunoglobulin. Human immunoglobulin may be an effective treatment for some dogs with immune-mediated anemia that fail to respond to conventional treatment.
Scott-Moncrieff
J C
JC
Department of Veterinary Clinical Sciences, Purdue University, West Lafayette, IN 47906, USA.
Reagan
W J
WJ
Glickman
L T
LT
DeNicola
D B
DB
Harrington
D
D
D000747:Anemia, Hypochromic / Q000628:therapy / Q000662:veterinary*; D000748:Anemia, Macrocytic / Q000628:therapy / Q000662:veterinary*; D000818:Animals; D001707:Biopsy, Needle / Q000662:veterinary; D001853:Bone Marrow / Q000473:pathology; D004283:Dog Diseases / Q000628:therapy*; D004285:Dogs; D005260:Female; D006801:Humans; D007116:Immunization, Passive / Q000662:veterinary*; D007262:Infusions, Intravenous / Q000662:veterinary; D011241:Prednisone / Q000627:therapeutic use; D005719:gamma-Globulins / Q000008:administration & dosage
D005719:gamma-Globulins; D011241:Prednisone