title: Effect of kainate-induced seizure activity on the polyamine interconversion pathway in juvenile rat brain.
abstract: The activity of the polyamine interconversion pathway was investigated in the hippocampus and piriform cortex after systemic KA administration in juvenile rats. Pretreatment of 7-day-old rats with the polyamine oxidase inhibitor, MDL 72527, induced a similar accumulation of N-acetylspermidine and N-acetylspermine in control and kainate-treated animals. The results indicate that KA-induced seizure activity has no effect on the polyamine interconversion pathway in developing rat brain.
authors.affiliation: Neuroscience Program, University of Southern California, Los Angeles 90089-2520, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: M
authors.initials: M
authors.lastname: Baudry
mesh_terms: D000107:Acetylation; D000367:Age Factors; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism* / Q000503:physiopathology; D004827:Epilepsy / Q000378:metabolism; D006624:Hippocampus / Q000378:metabolism* / Q000503:physiopathology; D007608:Kainic Acid; D011073:Polyamines / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism*
chemical_list: D011073:Polyamines; D007608:Kainic Acid