Biochemical and functional markers of lung damage after bleomycin treatment.
Lung function tests, including spirometry, and pulmonary transfer factor for carbon monoxide (TLCO), serum angiotensin-converting enzyme (sACE), serum copper (sCU++) and serum procollagen III peptide (sPIIIP) were measured in 20 patients with metastatic testicular carcinoma, before and after treatment with cisplatin, bleomycin, vinblastine or etoposide. A significant decrease of TLCO, total lung capacity and vital capacity was observed at the end of the treatment. No recovery of pulmonary function had taken place 2 yrs after the last dose of bleomycin. This result suggests that bleomycin-induced lung damage is not completely reversible. Serum angiotensin-converting enzyme, remained unmodified, whilst sPIIIP was found to be significantly increased at the end of chemotherapy, but normal 2 yrs after the completion of chemotherapy. Serum Cu++ showed a tendency to decline. No significant correlation was found between sACE, sCu++ and sPIIIP and lung function tests in the follow-up period. These results question the possibility that these markers could be useful indicators of bleomycin-induced lung damage.
Villani
F
F
Divisione di Fisiopatologia Cardiorespiratoria e di Analisi Cliniche e Microbiologia, Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italia.
Galimberti
M
M
Barbieri
A
A
Luisetti
M
M
Bacchella
L
L
Aprile
C
C
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D015415:Biomarkers / Q000097:blood; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects*; D003300:Copper / Q000097:blood; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010446:Peptide Fragments / Q000097:blood; D007703:Peptidyl-Dipeptidase A / Q000097:blood; D011347:Procollagen / Q000097:blood; D011658:Pulmonary Fibrosis / Q000097:blood / Q000139:chemically induced* / Q000175:diagnosis; D012129:Respiratory Function Tests; D013736:Testicular Neoplasms / Q000188:drug therapy* / Q000473:pathology; D013997:Time Factors
D015415:Biomarkers; D010446:Peptide Fragments; D011347:Procollagen; C041876:procollagen Type III-N-terminal peptide; D001761:Bleomycin; D003300:Copper; D007703:Peptidyl-Dipeptidase A