Oral tolerance: mobilizing the gut.
Immunologically active lymphoid tissue in gut mucosa is preferentially programmed to inhibit autoimmune reactions, a property that can be exploited by oral administration of self-antigen. Identifying the target autoantigens to use in oral preparations may not be necessary. The trigger for oral tolerization is antigen-specific, but suppressive events in the target organ are nonspecific.
Weiner
H L
HL
Harvard University, Boston, USA.
D000284:Administration, Oral; D000818:Animals; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology* / Q000628:therapy; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods*; D007413:Intestinal Mucosa / Q000276:immunology*; D010581:Peyer's Patches / Q000276:immunology*; D051381:Rats; D011917:Rats, Inbred Lew; D017634:Self Tolerance / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology
D001324:Autoantigens