Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats.
We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.
Maggio
R
R
Institute of Pharmacology, School of Medicine, University of Pisa, Italy.
Fumagalli
F
F
Donati
E
E
Barbier
P
P
Racagni
G
G
Corsini
G U
GU
Riva
M
M
D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004357:Drug Synergism; D007274:Injections, Intraperitoneal; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D019001:Nitric Oxide Synthase; D019335:Nitroarginine; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced*
D010862:Pilocarpine; D019335:Nitroarginine; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D007608:Kainic Acid