Mutagenicity of carboline methyl derivatives in Salmonella.
A series of linear, methyl-substituted derivatives of 5H-indolo[2,3-b] quinolines was tested for mutagenic activity with the battery of Ames tester strains. Mutagenic activity of indoloquinolones was strongly influenced by the position and a number of methyl groups. All compounds tested, with one exception, act like frame-shift mutagens. Only two compounds among them were mutagenic in the strain detecting oxidative and cross-linking mutagens.
Rahden-Staroń
I
I
Department of Biochemistry, Medical School, Warsaw, Poland.
Peczyńska-Czoch
W
W
Kaczmarek
L
L
D002243:Carbolines / Q000138:chemical synthesis / Q000494:pharmacology*; D016368:Frameshift Mutation; D009152:Mutagenicity Tests; D009153:Mutagens / Q000494:pharmacology*; D011804:Quinolines / Q000138:chemical synthesis / Q000494:pharmacology*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics*; D013329:Structure-Activity Relationship
D002243:Carbolines; D009153:Mutagens; D011804:Quinolines