title: Regulation of the interferon-induced PKR: can viruses cope?
abstract: Viruses that fail to block the lethal effects of the double-stranded-RNA-activated protein kinase (PKR) may be doomed; why do so many viruses go to so much trouble to downregulate this interferon-induced protein kinase? PKR may regulate cell growth and proliferation in uninfected cells, suggesting that it also participates in the antiproliferative arm of the interferon response.
authors.affiliation: Dept of Microbiology, School of Medicine, University of Washington, Seattle 98195, USA.
authors.forename: M G
authors.initials: MG
authors.lastname: Katze
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic; D004790:Enzyme Induction; D015967:Gene Expression Regulation, Viral; D050956:HSP40 Heat-Shock Proteins; D006801:Humans; D007372:Interferons / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000037:antagonists & inhibitors / Q000502:physiology*; D012097:Repressor Proteins / Q000502:physiology; D018406:Virus Physiological Phenomena; D019892:eIF-2 Kinase
chemical_list: C494651:DNAJC3 protein, human; D050956:HSP40 Heat-Shock Proteins; D012097:Repressor Proteins; D007372:Interferons; D017346:Protein Serine-Threonine Kinases; D019892:eIF-2 Kinase