title: Biliary amylase and congenital choledochal dilatation.
abstract: The relationship between levels of biliary amylase measured at operation and clinical features was studied in a series of 55 children with congenital biliary dilatation (choledochal cyst) who presented between 1976 and 1993. There were 36 cystic and 19 fusiforms dilatations in the series. The most common modes of presentation were painless jaundice (n = 23) and pancreatitis (n = 22). Five infants presented with abnormal antenatal ultrasound examinations. Children with pancreatitis were older than those with painless jaundice (4.2 versus 1.5 years; P = .005), and a higher proportion had raised levels of biliary amylase (100% versus 44%; P < .0001). There was no difference in the age at presentation (P = .32), clinical mode of presentation (P = .3), or the level of biliary amylase (P = .25) between cystic and fusiform dilatations. A correlation was found between age at surgery and biliary amylase in the cystic (rs = 0.55; P = .001) but not in the fusiform group (P = .22). All infants with antenatal diagnoses were cystic dilatations. Choledochal cystic dilatations that were diagnosed antenatally did not have significant amylase reflux, suggesting that the aetiology of this subgroup is truly congenital. Children who present at a later age with pancreatitis invariably have high levels of biliary amylase, which is presumed to occur because of a common channel and reflux of biliary and pancreatic secretions.
authors.affiliation: Department of Paediatric, Hepatobiliary Surgery, King's College Hospital, London, England.
authors.forename: M
authors.initials: M
authors.lastname: Davenport
authors.forename: M D
authors.initials: MD
authors.lastname: Stringer
authors.forename: E R
authors.initials: ER
authors.lastname: Howard
mesh_terms: D000293:Adolescent; D000681:Amylases / Q000032:analysis*; D001646:Bile / Q000201:enzymology*; D002648:Child; D002675:Child, Preschool; D015529:Choledochal Cyst / Q000145:classification / Q000150:complications / Q000175:diagnosis*; D004796:Clinical Enzyme Tests; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007565:Jaundice / Q000209:etiology; D010195:Pancreatitis / Q000209:etiology
chemical_list: D000681:Amylases