Amelioration of bleomycin-induced lung fibrosis in hamsters by dietary supplementation with taurine and niacin: biochemical mechanisms.
Interstitial pulmonary fibrosis induced by intratracheal instillation of bleomycin (BL) involves an excess production of reactive oxygen species, unavailability of adequate levels of NAD and ATP to repair the injured pulmonary epithelium, and an overexuberant lung collagen reactivity followed by deposition of highly cross-linked mature collagen fibrils resistant to enzymatic degradation. In the present study, we have demonstrated that dietary supplementation with taurine and niacin offered almost complete protection against the lung fibrosis in a multidose BL hamster model. The mechanisms for the protective effect of taurine and niacin are multifaceted. These include the ability of taurine to scavenge HOCl and stabilize the biomembrane; niacin's ability to replenish the BL-induced depletion of NAD and ATP; and the combined effect of taurine and niacin to suppress all aspects of BL-induced increases in the lung collagen reactivity, a hallmark of interstitial pulmonary fibrosis. It was concluded from the data presented at this Conference that the combined treatment with taurine and niacin, which offers a multipronged approach, will have great therapeutic potential in the intervention of the development of chemically induced interstitial lung fibrosis in animals and humans.
Giri
S N
SN
Department of Molecular Biosciences, University of California, Davis 95616.
Blaisdell
R
R
Rucker
R B
RB
Wang
Q
Q
Hyde
D M
DM
D000818:Animals; D001761:Bleomycin; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry / Q000166:cytology; D003094:Collagen / Q000378:metabolism; D006224:Cricetinae; D004032:Diet; D006909:Hydroxyproline / Q000378:metabolism; D008168:Lung / Q000378:metabolism / Q000473:pathology; D008297:Male; D008647:Mesocricetus; D009525:Niacin / Q000008:administration & dosage* / Q000627:therapeutic use; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000178:diet therapy* / Q000473:pathology; D013654:Taurine / Q000008:administration & dosage* / Q000627:therapeutic use
D001761:Bleomycin; D013654:Taurine; D009525:Niacin; D003094:Collagen; D008249:Protein-Lysine 6-Oxidase; D006909:Hydroxyproline