title: [Intrapleural bleomycin for management of malignant pleural effusions].
abstract: We studied the efficacy of intrapleural administration of bleomycin for the management of malignant pleural effusions of non-small cell lung cancer in 24 cases. Bleomycin 60 mg was administered into the pleural space after tube drainage. If the effusion continued, one additional dose was given. The efficacy was seen in 18 cases (75%). The main adverse drug reaction was transient fever among others. There was little toxicity and no cases of pulmonary fibrosis. Intrapleural administration of bleomycin is useful in management of malignant pleural effusions.
authors.affiliation: Dept. of Respiratory Medicine, Japanese Red Cross Society Wakayama Medical Center.
authors.forename: T
authors.initials: T
authors.lastname: Sugita
authors.forename: K
authors.initials: K
authors.lastname: Matsunaga
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Horikawa
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Nishiyama
authors.forename: N
authors.initials: N
authors.lastname: Maekawa
authors.forename: H
authors.initials: H
authors.lastname: Furuta
authors.forename: H
authors.initials: H
authors.lastname: Inui
authors.forename: H
authors.initials: H
authors.lastname: Fujimoto
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001761:Bleomycin / Q000008:administration & dosage*; D002289:Carcinoma, Non-Small-Cell Lung / Q000150:complications; D005260:Female; D006801:Humans; D015552:Injections, Intralesional; D008175:Lung Neoplasms / Q000150:complications; D008297:Male; D008875:Middle Aged; D010994:Pleura; D016066:Pleural Effusion, Malignant / Q000188:drug therapy* / Q000401:mortality; D015996:Survival Rate
chemical_list: D001761:Bleomycin