Biodegradable microspheres. XVIII: The adjuvant effect of polyacryl starch microparticles with conjugated human serum albumin.
The adjuvant effect of polyacryl starch microparticles was examined in mice using covalently coupled human serum albumin as a model antigen. Mice were immunized using different administration routes and the humoral and cellular immune responses were followed. The intraperitoneal immunizations gave the strongest humoral immune response, almost as high as with Freund's Complete Adjuvant (FCA), and the response after intravenous and intramuscular immunizations were somewhat lower. The delayed type hypersensitivity response was, after intramuscular immunization, about the same as after intraperitoneal immunizations with FCA. The results shows that polyacryl starch microparticles is a promising candidate for a new adjuvant for human use.
Degling
L
L
Division of Pharmacy, Medical Products Agency, Uppsala, Sweden.
Stjärnkvist
P
P
D000276:Adjuvants, Immunologic / Q000008:administration & dosage*; D000818:Animals; D000917:Antibody Formation; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes; D005260:Female; D006801:Humans; D006968:Hypersensitivity, Delayed; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D012709:Serum Albumin / Q000008:administration & dosage* / Q000276:immunology; D013213:Starch / Q000008:administration & dosage / Q000031:analogs & derivatives*
D000276:Adjuvants, Immunologic; D000939:Epitopes; D012709:Serum Albumin; D013213:Starch; C043831:starch polyacrylate