title: Neuroendocrine primary small cell carcinoma of the breast. Report of a case and review of the literature.
abstract: One case of breast neuroendocrine primary small cell carcinoma with light microscopic and immunohistochemical findings is reported. The patient died of unrelated disease 21 months after diagnosis and treatment by modified radical mastectomy, radiotherapy and subsequent chemotherapy. Immunohistochemical studies revealed cytokeratin and neuroendocrine markers (chromogranin, neuron-specific enolase) immunostaining on tumoral cells. Expression for neuropeptides (met-enkephalin, leu-enkephalin, beta-endorphin) and CALLA antigen was found. Based on this case report and six other previously reported cases, breast neuroendocrine primary small cell carcinoma appears to be a very aggressive tumor for which no firm conclusions regarding treatment can be drawn.
authors.affiliation: Department of Pathology, Centre Henri-Becquerel, Rouen, France.
authors.forename: A
authors.initials: A
authors.lastname: Francois
authors.forename: V A
authors.initials: VA
authors.lastname: Chatikhine
authors.forename: B
authors.initials: B
authors.lastname: Chevallier
authors.forename: G S
authors.initials: GS
authors.lastname: Ren
authors.forename: M
authors.initials: M
authors.lastname: Berry
authors.forename: A
authors.initials: A
authors.lastname: Chevrier
authors.forename: B
authors.initials: B
authors.lastname: Delpech
mesh_terms: D000368:Aged; D014408:Biomarkers, Tumor / Q000032:analysis; D001943:Breast Neoplasms / Q000175:diagnosis* / Q000628:therapy; D018288:Carcinoma, Small Cell / Q000175:diagnosis* / Q000628:therapy; D002864:Chromogranins / Q000032:analysis; D003593:Cytoplasm / Q000473:pathology; D004743:Enkephalin, Leucine / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007633:Keratins / Q000032:analysis; D008327:Mammography; D015411:Mastectomy, Modified Radical; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D018714:Radiotherapy, Adjuvant; D001615:beta-Endorphin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D002864:Chromogranins; D004743:Enkephalin, Leucine; D001615:beta-Endorphin; D007633:Keratins; D010751:Phosphopyruvate Hydratase