Antiperoxide effects of S-allyl cysteine sulphoxide isolated from Allium sativum Linn and gugulipid in cholesterol diet fed rats.
Cholesterol containing diet significantly increased not only the body weight, but also the weight of liver and adipose tissue of rats. This is accompanied by a significant increase in blood lipids, atherogenic index and lipid peroxidation and a significant decrease in reduced glutathione level, superoxide dismutase and catalase activities in tissues. Treatment with S-allyl cysteine sulphoxide reverses the deleterious effects of cholesterol diet significantly and almost as effectively as gugulipid.
Sheela
C G
CG
Department of Biochemistry, University of Kerala, India.
Augusti
K T
KT
D000490:Allium / Q000737:chemistry*; D000818:Animals; D002791:Cholesterol, Dietary / Q000494:pharmacology*; D029744:Commiphora; D003545:Cysteine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D010936:Plant Extracts / Q000494:pharmacology*; D053149:Plant Gums; D051381:Rats; D017207:Rats, Sprague-Dawley
D002791:Cholesterol, Dietary; D000960:Hypolipidemic Agents; D010936:Plant Extracts; D053149:Plant Gums; C018562:guggulu extract; C006453:alliin; D003545:Cysteine