[An experimental study on the relationship between disc nutrition and disc degeneration].
Micro-angiography, scanning electron microscopy and hydrogen washout technique were used to investigate the disc nutrition condition and the nutritional pathway of endplate in bipedal rats with agting. Compared with the controls, the nutrition condition of bipedal rats underwent deterioration and the number of vascular distribution under the endplate decreased significantly, but no increase in thickness of endplate caused by microfractures of subchondral bone and callus formed during the healing process was observed. The abnormal stress may bring about vertebral body intra-osseous circulation disorder and then consequent decrease of vascular channels which related to the disturbance of disc nutrition. This strongly suggested that nutrition conditions of nucleus pulposus were not deteriorated by impaired diffusion capacity, but by decrease of vasculature that contacts with endplate.
Dong
F
F
Ninth People's Hospital, Shanghai Second Medical University.
Dai
K
K
Hou
X
X
D000792:Angiography; D000818:Animals; D007403:Intervertebral Disc / Q000098:blood supply* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D051381:Rats; D017207:Rats, Sprague-Dawley; D013122:Spinal Diseases / Q000209:etiology* / Q000473:pathology; D013314:Stress, Mechanical