C-myc amplification, double minutes and homogenous staining regions in a case of AML.
c-myc amplification is usually associated with lymphoid malignancies and Burkitt's lymphoma in particular. We present a case of AML with c-myc amplification which was associated with homogenous staining regions (hsr) and double minutes (dmin). The administration of GCSF following induction chemotherapy resulted in a marked increase in blast numbers. The GCSF was stopped and further courses of chemotherapy given, which resulted in complete remission. The patient relapsed 7 months after diagnosis and failed to go into a second remission with reinduction therapy. We conclude that c-myc amplification is a rare event in AML, but may be associated with chemotherapy resistance and a poor prognosis, are as dmins and hsr. Growth factors should be used with caution in these patients.
Fegan
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CD
Department of Haematology, University Hospital of Wales, Cardiff.
White
D
D
Sweeney
M
M
D000368:Aged; D002869:Chromosome Aberrations; D002898:Chromosomes, Human, Pair 8; D004351:Drug Resistance; D005784:Gene Amplification; D016259:Genes, myc; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015470:Leukemia, Myeloid, Acute / Q000235:genetics* / Q000628:therapy; D008297:Male
D016179:Granulocyte Colony-Stimulating Factor