High endothelial venules (HEVs): specialized endothelium for lymphocyte migration.
High endothelial venules (HEVs) are specialized postcapillary venules found in lymphoid tissues that support high levels of lymphocyte extravasation from the blood. Here, Jean-Philippe Girard and Timothy Springer highlight the unique properties of HEV endothelium, discuss the molecular mechanisms controlling HEV specialization and review evidence suggesting that HEVs could play an important role in the pathogenesis of chronic inflammatory diseases.
Girard
J P
JP
Laboratoire de Biologie Moléculaire Eucaryote (LBME) du CNRS, Toulouse, France.
Springer
T A
TA
D000818:Animals; D000954:Antigens, Surface / Q000378:metabolism; D015415:Biomarkers; D001812:Blood-Brain Barrier / Q000276:immunology; D002465:Cell Movement; D004729:Endothelium, Lymphatic / Q000166:cytology / Q000276:immunology*; D006031:Glycosylation; D006801:Humans; D007249:Inflammation / Q000209:etiology; D019041:L-Selectin / Q000378:metabolism; D008214:Lymphocytes / Q000166:cytology / Q000276:immunology*; D008565:Membrane Proteins
D000954:Antigens, Surface; D015415:Biomarkers; C069886:L-selectin counter-receptors; D008565:Membrane Proteins; D019041:L-Selectin