title: Postnatal development of nitric oxide synthase type 1 expression in the lumbar spinal cord of the rat: a comparison with the induction of c-fos in response to peripheral application of mustard oil.
abstract: The distribution of the neuronal isoform of the enzyme nitric oxide synthase (type 1) has been investigated in the lumbar spinal cords of neonatal rats (2-20 days old). Large multipolar neurones were present from day 2 around the central canal, in a band across the neck of the dorsal horn and at the thoracic level in the intermediolateral cell column, whereas staining was absent from laminae II. By 20 days the laminae II staining was similar to that found in the adult. NOS expression in lamina II paralleled the development of c-fos expression in this lamina in response to peripheral application of mustard oil.
authors.affiliation: Department of Veterinary Preclinical Sciences, University of Liverpool, UK.
authors.forename: Z
authors.initials: Z
authors.lastname: Soyguder
authors.forename: H H
authors.initials: HH
authors.lastname: Schmidt
authors.forename: R
authors.initials: R
authors.lastname: Morris
mesh_terms: D000287:Administration, Topical; D000344:Afferent Pathways / Q000254:growth & development; D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D000831:Animals, Newborn; D003875:Drug Eruptions / Q000209:etiology / Q000235:genetics / Q000503:physiopathology*; D004790:Enzyme Induction; D005528:Foot; D018507:Gene Expression Regulation, Developmental; D007509:Irritants / Q000008:administration & dosage / Q000633:toxicity*; D009149:Mustard Plant; D009419:Nerve Tissue Proteins / Q000096:biosynthesis* / Q000235:genetics; D009474:Neurons / Q000201:enzymology*; D019001:Nitric Oxide Synthase; D010146:Pain / Q000503:physiopathology; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity*; D010938:Plant Oils; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis* / Q000235:genetics; D051381:Rats; D013116:Spinal Cord / Q000187:drug effects / Q000201:enzymology* / Q000254:growth & development
chemical_list: D007509:Irritants; D009419:Nerve Tissue Proteins; D010936:Plant Extracts; D010938:Plant Oils; D016760:Proto-Oncogene Proteins c-fos; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; C027793:mustard oil