Monoclonal IgM reactive with several gangliosides in a chronic relapsing polyneuropathy.
A possibly pathogenic serum monoclonal IgM lambda from a patient with chronic relapsing polyneuropathy was shown to react with the disialosyl-lactosyl residue (NeuAc alpha 2-8NeuAc alpha 2-3) -Gal beta 1-4Glc expressed by GD1b, GT1b, GQ1b, GD2 and GD3. A part of this epitope in terminal position in GM3, GD1a and LM1 was also recognized by the IgM lambda.
Brindel
I
I
Laboratories of Immunology, Limoges University Hospital, France.
Preud'homme
J L
JL
Vallat
J M
JM
Vincent
D
D
Vasquez
J L
JL
Jauberteau
M O
MO
D000368:Aged; D000911:Antibodies, Monoclonal / Q000276:immunology*; D002855:Chromatography, Thin Layer; D002908:Chronic Disease; D004591:Electrophoresis, Polyacrylamide Gel; D004797:Enzyme-Linked Immunosorbent Assay; D000939:Epitopes; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007075:Immunoglobulin M / Q000276:immunology*; D007146:Immunoglobulin lambda-Chains / Q000276:immunology; D009439:Neuraminidase / Q000494:pharmacology; D010523:Peripheral Nervous System Diseases / Q000276:immunology*; D012008:Recurrence
D000911:Antibodies, Monoclonal; D000939:Epitopes; D005732:Gangliosides; D007075:Immunoglobulin M; D007146:Immunoglobulin lambda-Chains; D009439:Neuraminidase