CD1 recognition by mouse NK1+ T lymphocytes.
Rare major histocompatibility complex (MHC) class I-like CD1-specific T cells have been isolated from human blood, but it has not been determined whether these clones are part of a defined subset of CD1-specific T cells selected during T cell development, or whether their recognition of CD1 is a fortuitous cross-reaction. In mice, an entire subset of alpha beta thymocytes with a unique phenotype was found to be CD1-specific. This particular subset, and its human counterpart, provide evidence that CD1 has a general role in selecting and interacting with specialized alpha beta T cells.
Bendelac
A
A
Department of Molecular Biology, Princeton University, NJ 08544, USA.
Lantz
O
O
Quimby
M E
ME
Yewdell
J W
JW
Bennink
J R
JR
Brutkiewicz
R R
RR
D000818:Animals; D000941:Antigens / Q000032:analysis; D015703:Antigens, CD / Q000276:immunology*; D018949:Antigens, CD1; D000954:Antigens, Surface; D002460:Cell Line; D006801:Humans; D006825:Hybridomas; D015847:Interleukin-4 / Q000378:metabolism; D037181:Lectins, C-Type; D008024:Ligands; D051379:Mice; D008810:Mice, Inbred C57BL; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011506:Proteins / Q000032:analysis; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D000941:Antigens; D015703:Antigens, CD; D018949:Antigens, CD1; D000954:Antigens, Surface; C527203:KLRB1 protein, human; D037181:Lectins, C-Type; D008024:Ligands; D055651:NK Cell Lectin-Like Receptor Subfamily B; D011506:Proteins; D016693:Receptors, Antigen, T-Cell, alpha-beta; D015847:Interleukin-4