title: Inhibition of nitric oxide synthase dramatically potentiates seizures induced by kainic acid and pilocarpine in rats.
abstract: We investigated whether the severity of convulsions evoked by kainic acid and pilocarpine is modified in nitric oxide synthase inhibitor-treated rats. We found that chronic treatment (4 days) with NW-nitro-L-arginine greatly potentiates seizures induced by both convulsants suggesting a potential role for nitric oxide in mechanisms regulating seizure induction and propagation.
authors.affiliation: Institute of Pharmacology, School of Medicine, University of Pisa, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Maggio
authors.forename: F
authors.initials: F
authors.lastname: Fumagalli
authors.forename: E
authors.initials: E
authors.lastname: Donati
authors.forename: P
authors.initials: P
authors.lastname: Barbier
authors.forename: G
authors.initials: G
authors.lastname: Racagni
authors.forename: G U
authors.initials: GU
authors.lastname: Corsini
authors.forename: M
authors.initials: M
authors.lastname: Riva
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D004357:Drug Synergism; D007274:Injections, Intraperitoneal; D007608:Kainic Acid / Q000494:pharmacology*; D008297:Male; D019001:Nitric Oxide Synthase; D019335:Nitroarginine; D010862:Pilocarpine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000139:chemically induced*
chemical_list: D010862:Pilocarpine; D019335:Nitroarginine; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D007608:Kainic Acid