Length-tension dependence in vascular smooth muscle: possible participation of endothelin.
The results of experiments with isolated strips of rat portal vein, and of 'sandwich' experiments involving strips of the portal vein or aorta, revealed the involvement of endothelin in the development of myogenic reactions of the vascular smooth muscle, observed on distension of the vascular wall. Released by the endothelial cells, endothelin is capable of stimulating the contraction of these muscles.
Tkachenko
M N
MN
Department of Physiology of Circulation, A. A. Bogomolets Institute of Physiology, National Academy of Sciences of Ukraine, Kiev, Ukraine.
Sagach
V F
VF
D000818:Animals; D016282:Aspartic Acid Endopeptidases / Q000037:antagonists & inhibitors; D000072396:Endothelin-Converting Enzymes; D016232:Endothelins / Q000502:physiology*; D006020:Glycopeptides / Q000494:pharmacology; D066298:In Vitro Techniques; D008666:Metalloendopeptidases; D009119:Muscle Contraction; D009131:Muscle, Smooth, Vascular / Q000502:physiology*; D011169:Portal Vein; D011480:Protease Inhibitors / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar
D016232:Endothelins; D006020:Glycopeptides; D011480:Protease Inhibitors; D016282:Aspartic Acid Endopeptidases; D008666:Metalloendopeptidases; D000072396:Endothelin-Converting Enzymes; C008890:phosphoramidon