title: Involvement of clathrin light chains in the pathology of Pick's disease; implication for impairment of axonal transport.
abstract: Clathrin, which constitutes coated vesicles and plays important roles in neuronal functions, has been reported to be involved in the pathology of Alzheimer's disease. In the brains of the patients with Pick's disease, distribution of clathrin was immunohistochemically investigated using monoclonal antibodies binding to different epitopes of clathrin light chain a and b. All the antibodies intensely labeled Pick's body and some perikarya of neurons, indicating impairment of slow axonal transport b (SCb). Antibodies against neurofilament, kinesin and synaptophysin also labeled Pick's body. These observations suggested impairment of axonal transport in the brains with Pick's disease, and might contribute to elucidating the pathology of Pick's body forming. It is implied that common pathological processes might lie in Alzheimer's disease and Pick's disease.
authors.affiliation: Department of Neuropsychiatry, Osaka University Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Takeda
authors.forename: K
authors.initials: K
authors.lastname: Yoshimi
authors.forename: H
authors.initials: H
authors.lastname: Hattori
authors.forename: S
authors.initials: S
authors.lastname: Hariguchi
authors.forename: S
authors.initials: S
authors.lastname: Hashimoto
authors.forename: T
authors.initials: T
authors.lastname: Nishimura
mesh_terms: D000911:Antibodies, Monoclonal; D001370:Axonal Transport / Q000502:physiology*; D001921:Brain / Q000473:pathology; D002966:Clathrin / Q000378:metabolism*; D003704:Dementia / Q000378:metabolism* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D016547:Kinesins / Q000378:metabolism; D016900:Neurofilament Proteins / Q000378:metabolism; D016708:Synaptophysin / Q000378:metabolism
chemical_list: D000911:Antibodies, Monoclonal; D002966:Clathrin; D016900:Neurofilament Proteins; D016708:Synaptophysin; D016547:Kinesins