gp120 neurotoxicity in primary cortical cultures.
The human immunodeficiency virus type 1 coat protein, gp120, kills neurons in a nitric oxide dependent manner in primary cortical cultures at low picomolar concentrations. gp120 neurotoxicity also requires calcium and glutamate and is blocked by glutamate receptor antagonists. In addition, superoxide anions play a role in gp120 neurotoxicity since superoxide dismutase also attenuates neurotoxicity.
Dawson
T M
TM
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD 21287.
Dawson
V L
VL
D015526:AIDS Dementia Complex / Q000209:etiology; D000594:Amino Acid Oxidoreductases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000502:physiology; D002121:Calcium Channel Blockers / Q000494:pharmacology; D002478:Cells, Cultured; D002540:Cerebral Cortex / Q000166:cytology; D016207:Cytokines / Q000502:physiology; D003588:Cytopathogenic Effect, Viral; D015777:Eicosanoids / Q000502:physiology; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology; D018698:Glutamic Acid / Q000502:physiology; D015699:HIV Envelope Protein gp120 / Q000633:toxicity*; D015497:HIV-1; D006801:Humans; D009474:Neurons / Q000187:drug effects* / Q000473:pathology; D019001:Nitric Oxide Synthase; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects / Q000502:physiology; D013482:Superoxide Dismutase / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism
D002121:Calcium Channel Blockers; D016207:Cytokines; D015777:Eicosanoids; D018691:Excitatory Amino Acid Antagonists; D015699:HIV Envelope Protein gp120; D016194:Receptors, N-Methyl-D-Aspartate; D013481:Superoxides; D018698:Glutamic Acid; D019001:Nitric Oxide Synthase; D013482:Superoxide Dismutase; D000594:Amino Acid Oxidoreductases; D002118:Calcium