title: Influence of bolus volume and dose of gadolinium chelate for first-pass myocardial perfusion MR imaging studies.
abstract: First-pass MR myocardial perfusion measurements require a well-defined left ventricular (LV) blood pool input function. We used a peripheral intravenous (i.v.) injection of a gadolinium (Gd) chelate to obtain a well-characterized LV time-intensity curve. Using a strongly T1-weighted subsecond MR sequence, we performed cardiac MR imaging after administering an IV bolus injection of one of three different doses of the Gd chelate: a standard dose (0.1 mmol/kg, group I, n = 8); a low dose with two bolus volumes (0.01 mmol/kg, 1/10e bolus volume, group II, n = 7, and 0.01 mmol/kg diluted in saline, same bolus volume as group I, group III, n = 3); and an intermediate dose (0.05 mmol/kg, group IV, n = 5). Unlike in group I (high dose), in groups II and III (low dose), the LV curve had a well-defined first peak, followed by a downslope and a recirculation peak. With the intermediate dose (group IV), a saturation effect still remained on the LV curve. The signal intensity (SI) enhancement of the myocardium was respectively 580 +/- 77% at 0.1 mmol/kg, 362 +/- 95% at 0.05 mmol/kg, and at 0.01 mmol/kg, it was 184 +/- 33% in group II and 272 +/- 8% in group III. In conclusion, with subsecond T1-weighted MR imaging and a low dose of Gd chelate (i.e., 0.01 mmol/kg), the LV input function is a well-defined first step for MR perfusion modeling.
authors.affiliation: Service de Radiologie, Professeur M. Amiel Hôpital Cardiovasculaire et Pneumologique, Lyon, France.
authors.forename: E
authors.initials: E
authors.lastname: Canet
authors.forename: P
authors.initials: P
authors.lastname: Douek
authors.forename: M
authors.initials: M
authors.lastname: Janier
authors.forename: K
authors.initials: K
authors.lastname: Bendid
authors.forename: J
authors.initials: J
authors.lastname: Amaya
authors.forename: P
authors.initials: P
authors.lastname: Millet
authors.forename: D
authors.initials: D
authors.lastname: Revel
mesh_terms: D003287:Contrast Media / Q000008:administration & dosage*; D006321:Heart / Q000033:anatomy & histology*; D006571:Heterocyclic Compounds / Q000008:administration & dosage; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000379:methods; D017202:Myocardial Ischemia / Q000175:diagnosis*; D009206:Myocardium / Q000473:pathology; D009942:Organometallic Compounds / Q000008:administration & dosage; D010865:Pilot Projects; D016277:Ventricular Function, Left / Q000502:physiology*
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate