title: [The effect of interferon-beta on experimental choroidal neovascularization].
abstract: We studied histologically the effect of systemic administration of human interferon-beta (IFN-beta) on experimental choroidal neovascularization which was caused by intensive laser photocoagulation at the posterior pole of monkey eyes. The regression of choroidal neovascularization was observed in IFN-treated monkeys. Histologically, retinal pigment epithelium (RPE) was remarkably abundant around choroidal neovascularization in the subretinal space, and the activity of neovascularization was weaker in IFN-treated monkeys than in untreated monkeys. These results indicate that IFN-beta promotes the proliferation of RPE and suppresses the activity of endothelial cells of neovascularization to cause regression of choroidal neovascularization. The results suggest that IFN-beta is clinically useful to treat the choroidal neovascularization of age-related macular degeneration.
authors.affiliation: Department of Ophthalmology, Kansai Medical University, Osaka-fu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tobe
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Ohkuma
authors.forename: M
authors.initials: M
authors.lastname: Uyama
mesh_terms: D000818:Animals; D002829:Choroid / Q000098:blood supply*; D016899:Interferon-beta / Q000627:therapeutic use*; D017075:Laser Coagulation; D008252:Macaca fascicularis; D009389:Neovascularization, Pathologic / Q000188:drug therapy*
chemical_list: D016899:Interferon-beta