title: Development of melanoma throughout two close pregnancies. Case report.
abstract: Primary melanoma is the most malignant and the least frequent of all cutaneous tumors. Its incidence in pregnancy varies from 0.1 to 2.8/1000. Up to today, impact of pregnancy on melanoma's course is still a much debated question in the literature. Some earlier reports suggested a particularly serious prognosis for melanoma associated with pregnancy, while more recent studies show that pregnancy may influence relapses without significantly altering survival. This paper reports the case of a woman affected by melanoma, whose clinical conditions became more and more serious during her second pregnancy and the following puerperal period. The progressive impairment of her clinical condition has suggested a correlation between the two close pregnancies and the unfavourable course of her disease.
authors.affiliation: Cattedra di Fisiopatologia, della Riproduzione Umana, Università degli Studi di Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Diaferia
authors.forename: P L
authors.initials: PL
authors.lastname: Nicastri
authors.forename: M
authors.initials: M
authors.lastname: Tartagni
authors.forename: P
authors.initials: P
authors.lastname: Loizzi
authors.forename: M M
authors.initials: MM
authors.lastname: Manzionna
authors.forename: A
authors.initials: A
authors.lastname: Mautone
mesh_terms: D000328:Adult; D001365:Axilla; D001706:Biopsy; D005260:Female; D005542:Forearm; D006801:Humans; D008197:Lymph Node Excision; D008207:Lymphatic Metastasis / Q000473:pathology; D008545:Melanoma / Q000145:classification / Q000473:pathology; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D012878:Skin Neoplasms / Q000473:pathology