title: 5-hydroxy-3-vinyl-2(5H)-furanone--a new inhibitor of human synovial phospholipase A2 and platelet aggregation from fermentations of a Calyptella species (basidiomycetes).
abstract: 5-Hydroxy-3-vinyl-2(5H)-furanone, a potent and selective inhibitor of human synovial phospholipase A2 was isolated from fermentations of a Calyptella species. Its structure as identified by spectroscopic methods is identical to PA 147, an antibiotic previously isolated from a streptomycete. 5-hydroxy-3-vinyl-2(5H)-furanone inhibits the aggregation of human and bovine platelets stimulated by different inducers and exhibits weak antimicrobial activities.
authors.affiliation: LB Biotechnologie der Universität, Kaiserslautern, Bundesrepublik Deutschland.
authors.forename: K
authors.initials: K
authors.lastname: Lorenzen
authors.forename: T
authors.initials: T
authors.lastname: Anke
authors.forename: S
authors.initials: S
authors.lastname: Konetschny-Rapp
authors.forename: W
authors.initials: W
authors.lastname: Scheuer
mesh_terms: D015107:4-Butyrolactone / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000818:Animals; D001487:Basidiomycota / Q000254:growth & development; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D002417:Cattle; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D003600:Cytosol / Q000201:enzymology; D004791:Enzyme Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006801:Humans; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010179:Pancreas / Q000201:enzymology; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D012910:Snake Venoms; D013583:Synovial Membrane / Q000201:enzymology; D013917:Thrombin / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D004791:Enzyme Inhibitors; D010975:Platelet Aggregation Inhibitors; D012910:Snake Venoms; C096046:5-hydroxy-3-vinyl-2(5H)-furanone; D010741:Phospholipases A; D054467:Phospholipases A2; D013917:Thrombin; D015107:4-Butyrolactone