Crosslines, fluorophores in the AGE-related cross-linked proteins.
We can summarize our results as follows: (1) A pair of fluorescent crosslines were isolated from the Maillard reaction mixture; (2) AGE-proteins contained crossline-like structures, and (3) crossline-like immunoreactivities were accumulated in renal tissues of diabetic rats. From these results we concluded that fluorophores in AGE proteins have crossline-like structures and we had the first indication that XLs could be markers for renal disorders.
Ienaga
K
K
Institute of Bio-Active Science, Nippon Zoki Pharmaceutical Co. Ltd, Hyogo, Japan.
Nakamura
K
K
Hochi
T
T
Nakazawa
Y
Y
Fukunaga
Y
Y
Kakita
H
H
Nakano
K
K
D000818:Animals; D005453:Fluorescence; D017127:Glycation End Products, Advanced / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D015416:Maillard Reaction; D011506:Proteins / Q000378:metabolism*
D017127:Glycation End Products, Advanced; D011506:Proteins