Influence of ethanol on the salsolinol excretion in healthy subjects.
This report describes the change of salsolinol (SAL) levels in the urine of healthy subjects after ethanol ingestion. A new rapid method for SAL extraction from urine sample and a GC-MS assay were used to study the urinary SAL excretion in a group of adult males (n = 14) and females (n = 13) with and without ingestion of ethanol. The results of this study show that the urinary SAL output of all subjects is significantly influenced by the intake of ethanol. A decrease in the SAL level was found in the urine of most of the volunteers (n = 17), whereas only eight subjects showed an increase in the SAL level after administration of ethanol.
Haber
H
H
Research Institute for Molecular Pharmacology, Berlin, Germany.
Putscher
I
I
Georgi
M
M
Melzig
M F
MF
D000328:Adult; D000431:Ethanol / Q000494:pharmacology*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007546:Isoquinolines / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012016:Reference Values
D007546:Isoquinolines; D000431:Ethanol; C036617:salsolinol