title: Coxsackieviruses B1, B3, and B5 use decay accelerating factor as a receptor for cell attachment.
abstract: Receptor binding and subsequent cell-mediated internalization or disassembly are the initial steps in virus replication. Cell surface molecules that participate in this process are the primary determinants of virus tissue tropism. Monoclonal antibody blockade, immunoprecipitation, and DNA transfection were used to identify decay accelerating factor as a major cell attachment receptor for coxsackieviruses B1, B3, and B5. However, expression of human decay acceleration factor on the surface of nonpermissive murine fibroblasts led only to virus attachment without subsequent replication, and it was concluded that an additional cellular cofactor(s) is required to facilitate cell entry and subsequent replication.
authors.affiliation: Department of Microbiology, Faculty of Medicine, University of Newcastle, New South Wales, Australia.
authors.forename: D R
authors.initials: DR
authors.lastname: Shafren
authors.forename: R C
authors.initials: RC
authors.lastname: Bates
authors.forename: M V
authors.initials: MV
authors.lastname: Agrez
authors.forename: R L
authors.initials: RL
authors.lastname: Herd
authors.forename: G F
authors.initials: GF
authors.lastname: Burns
authors.forename: R D
authors.initials: RD
authors.lastname: Barry
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology; D015703:Antigens, CD / Q000378:metabolism*; D001665:Binding Sites; D018958:CD55 Antigens; D002460:Cell Line; D029822:Enterovirus B, Human / Q000378:metabolism* / Q000502:physiology; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D011991:Receptors, Virus / Q000378:metabolism*; D014779:Virus Replication / Q000276:immunology
chemical_list: D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D018958:CD55 Antigens; D008562:Membrane Glycoproteins; D011991:Receptors, Virus