title: Double-blind comparison of carbamazepine and placebo for treatment of cocaine dependence.
abstract: This study was conducted to determine the effectiveness of carbamazepine (CBZ) for treatment of cocaine dependence. Sixty-two (CBZ = 28, placebo = 34) cocaine-dependent (DSM-III-R criteria) volunteers consented to be treated for eight weeks with standardized outpatient individual counseling twice a week plus double-blind CBZ or inactive placebo. During the 8-week trial, both groups showed increased number of urine samples negative for cocaine, significantly (P < 0.01) decreased self-reported cocaine use (money spent and grams used), and decreased Beck Depression Inventory and Symptom Check List-90-Revised (SCL-90-R) total scores. However, there were no significant differences between CBZ and placebo. This study does not support the effectiveness of CBZ for outpatient treatment of cocaine dependence.
authors.affiliation: NIH/NIDA/Intramural Research Program, Treatment Branch, Baltimore, MD 21224, USA.
authors.forename: I D
authors.initials: ID
authors.lastname: Montoya
authors.forename: F R
authors.initials: FR
authors.lastname: Levin
authors.forename: P J
authors.initials: PJ
authors.lastname: Fudala
authors.forename: D A
authors.initials: DA
authors.lastname: Gorelick
mesh_terms: D000328:Adult; D000553:Ambulatory Care; D000927:Anticonvulsants / Q000627:therapeutic use*; D002220:Carbamazepine / Q000627:therapeutic use*; D003042:Cocaine; D003863:Depression / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007696:Kindling, Neurologic / Q000187:drug effects; D008297:Male; D009294:Narcotics; D010555:Personality Inventory; D019966:Substance-Related Disorders / Q000523:psychology / Q000534:rehabilitation*; D016896:Treatment Outcome
chemical_list: D000927:Anticonvulsants; D009294:Narcotics; D002220:Carbamazepine; D003042:Cocaine