title: Mesangiolysis associated with severe glomerular endocapillary proliferation of CD57 large granular lymphocytes.
abstract: A 54-year-old man developed renal failure, with renal biopsy findings of diffuse mesangiolysis with severe endocapillary proliferation. Immunohistochemical studies revealed that CD3-CD56-CD57+ large granular lymphocytes were present predominantly within glomerular tufts. Intercellular adhesion molecule-1 was more preferentially expressed in the glomerular endothelial cells with severe endocapillary proliferation as compared to those without endocapillary proliferation. These findings suggest that CD57+ large granular lymphocytes caused glomerular endothelial injury by a cell-mediated cytolytic mechanism, resulting in the development of mesangiolysis and microaneurysm formation.
authors.affiliation: Department of Nephrology, Sendai Shakaihoken Hospital, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Hotta
authors.forename: S
authors.initials: S
authors.lastname: Miyazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Taguma
authors.forename: S
authors.initials: S
authors.lastname: Onodera
authors.forename: H
authors.initials: H
authors.lastname: Kitamura
authors.forename: N
authors.initials: N
authors.lastname: Yusa
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
mesh_terms: D015703:Antigens, CD / Q000032:analysis*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis*; D001706:Biopsy; D018959:CD57 Antigens; D003520:Cyclophosphamide / Q000627:therapeutic use; D004176:Dipyridamole / Q000627:therapeutic use; D005920:Glomerular Mesangium / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis; D008297:Male; D008775:Methylprednisolone / Q000627:therapeutic use; D008854:Microscopy, Electron; D008856:Microscopy, Fluorescence; D008875:Middle Aged; D051437:Renal Insufficiency / Q000188:drug therapy / Q000378:metabolism / Q000473:pathology*; D016176:T-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D018959:CD57 Antigens; D018799:Intercellular Adhesion Molecule-1; D014859:Warfarin; D004176:Dipyridamole; D003520:Cyclophosphamide; D008775:Methylprednisolone