title: Serum tetranectin in patients with acute pelvic inflammatory disease (PID). Correlation to clinical and laboratory findings.
abstract: OBJECTIVE
  To clarify the impact of the presence of pelvic inflammatory disease (PID) and activation of the acute phase response on the serum level of tetranectin (Se-TN), a potential new tumor marker for ovarian cancer.
  
  
  METHODS
  The study group consisted of 70 patients with a laparoscopically verified PID and 47 healthy female controls.
  
  
  RESULTS
  Lower Se-TN levels were found for the PID group compared to the control group (p < 0.0001). It was not possible to relate the decreases in Se-TN levels to any distinct bacterial strain. Neither was it possible to find any correlation between Se-TN and severity of PID (p = 0.5). A significant positive correlation was found between Se-TN and ALB (p < 0.001). A just significant negative correlation was found between Se-TN and C-reactive protein (CRP) (p = 0.04), while no correlation was found with any of the other acute phase reactants. Highly significant correlations were found between all the acute phase reactants and grade of PID.
  
  
  CONCLUSIONS
  A slight, but significant reduction in Se-TN was found in PID patients. The decrease was minor compared to the reported findings of very low Se-TN levels for ovarian cancer patients. However, the finding is important in the assessment of TN used as a potential screening marker for ovarian cancer, or as a diagnostic tool for pelvic tumors. Furthermore, Se-TN does not seem to behave as a negative acute phase reactant.
authors.affiliation: Department of Clinical Biochemistry, Statens Seruminstitut, Copenhagen, Denmark.
authors.forename: C K
authors.initials: CK
authors.lastname: Høgdall
authors.forename: M
authors.initials: M
authors.lastname: Christiansen
authors.forename: C
authors.initials: C
authors.lastname: Brihmer
mesh_terms: D000209:Acute-Phase Proteins / Q000032:analysis*; D000328:Adult; D001424:Bacterial Infections / Q000097:blood / Q000175:diagnosis; D014408:Biomarkers, Tumor / Q000097:blood*; D001798:Blood Proteins / Q000032:analysis*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D010535:Laparoscopy; D037181:Lectins, C-Type; D010051:Ovarian Neoplasms / Q000097:blood / Q000175:diagnosis; D000292:Pelvic Inflammatory Disease / Q000097:blood* / Q000175:diagnosis / Q000382:microbiology
chemical_list: D000209:Acute-Phase Proteins; D014408:Biomarkers, Tumor; D001798:Blood Proteins; D037181:Lectins, C-Type; C048648:tetranectin