Soluble T-cell products antigenically related to T-cell receptors.
Human peripheral blood mononuclear cells (PBMC) cultured with or without concanavalin A (Con A) secrete soluble TCR alpha and TCR beta chains. Soluble TCR-like products of three different relative molecular masses--185,000 (Mr 185 kDa), 152 and 42 kDa--which are antigenically similar to those on T lymphocytes have been found in sera from healthy adult donors. These findings suggest that soluble TCRs, antigenically similar to cell surface TCRs, are secreted from T lymphocytes.
Ishizaka
S
S
Third Department of Internal Medicine, Nara Medical University, Kashihara, Japan.
Tsujii
T
T
D002478:Cells, Cultured; D003208:Concanavalin A / Q000494:pharmacology*; D000939:Epitopes; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D010446:Peptide Fragments / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000276:immunology*; D012995:Solubility; D013601:T-Lymphocytes / Q000276:immunology*
D000939:Epitopes; D010446:Peptide Fragments; D011948:Receptors, Antigen, T-Cell; D003208:Concanavalin A