title: Regulation of immune function by protein tyrosine phosphatases.
abstract: CD45 is a leukocyte transmembrane protein tyrosine phosphatase that functions in lymphocyte activation by increasing the kinase activity of Src family members. In contrast, an intracellular protein tyrosine phosphatase that contains Src homology 2 domains, SHP, is required to inactivate receptors. Recent studies have examined the mechanisms of interaction and regulation of these enzymes.
authors.affiliation: Howard Hughes Medical Institute, Department of Pathology, Washington University School of Medicine, St Louis, MO 63130, USA.
authors.forename: M
authors.initials: M
authors.lastname: Okumura
authors.forename: M L
authors.initials: ML
authors.lastname: Thomas
mesh_terms: D000818:Animals; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D017493:Leukocyte Common Antigens / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000276:immunology*; D054593:SH2 Domain-Containing Protein Tyrosine Phosphatases; D015398:Signal Transduction / Q000276:immunology; D018909:src Homology Domains / Q000276:immunology
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D017493:Leukocyte Common Antigens; C516724:PTPN11 protein, human; C509249:PTPN6 protein, human; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases; C516725:Ptpn11 protein, mouse; C509248:Ptpn6 protein, mouse; D054593:SH2 Domain-Containing Protein Tyrosine Phosphatases