title: Could HLA-DRB1 be the protective locus in rheumatoid arthritis?
abstract: Extensive studies in different ethnic groups have associated the susceptibility to development of rheumatoid arthritis (RA) with the third hypervariable region of the major histocompatibility complex (MHC) HLA-DR beta 1 molecule. On the basis of recent findings in the experimental mouse model of collagen-induced arthritis, Eric Zanelli, Miguel Gonzalez-Gay and Chella David propose that the HLA-DRB1 locus is associated with protection to RA and that the actual arthritogenic peptide-presenting molecule is HLA-DQ. Thus, the development of RA would depend upon the expression of the susceptible DQ allele and the nonprotective DRB1 alleles, along with environmental factors that trigger the autoimmune process.
authors.affiliation: Dept of Immunology, Mayo Clinic, Rochester, MN 55905, USA.
authors.forename: E
authors.initials: E
authors.lastname: Zanelli
authors.forename: M A
authors.initials: MA
authors.lastname: Gonzalez-Gay
authors.forename: C S
authors.initials: CS
authors.lastname: David
mesh_terms: D000483:Alleles; D000818:Animals; D017951:Antigen Presentation; D001168:Arthritis / Q000139:chemically induced / Q000235:genetics / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D001327:Autoimmune Diseases / Q000208:ethnology / Q000235:genetics* / Q000276:immunology; D003094:Collagen / Q000633:toxicity; D004195:Disease Models, Animal; D004198:Disease Susceptibility / Q000208:ethnology / Q000276:immunology; D004200:Diseases in Twins; D000939:Epitopes / Q000276:immunology; D020022:Genetic Predisposition to Disease; D006683:HLA-DQ Antigens / Q000235:genetics / Q000276:immunology; D059866:HLA-DQ beta-Chains; D006684:HLA-DR Antigens / Q000235:genetics* / Q000276:immunology; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II / Q000235:genetics* / Q000276:immunology; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D011110:Polymorphism, Genetic; D016176:T-Lymphocyte Subsets / Q000276:immunology
chemical_list: D000939:Epitopes; D006683:HLA-DQ Antigens; D059866:HLA-DQ beta-Chains; C069051:HLA-DQB1 antigen; D006684:HLA-DR Antigens; D059811:HLA-DRB1 Chains; D000949:Histocompatibility Antigens Class II; C024138:I-E-antigen; D003094:Collagen