title: [Oral non-Hodgkin lymphomas and Epstein-Barr virus].
abstract: The oropharynx is the site of primary infection and further propagation of the Epstein-Barr virus (EBV). From here, virus is shed to saliva and infects peripheral blood lymphocytes. Eight oral Non-Hodgkin lymphomas (NHL) were investigated for the presence of EBV both by immunohistochemistry for the latent membrane protein (LMP) and a PCR-strategy for general and subtype-specific viral sequences. All but one NHL turned out to be negative both by LMP and PCR. EBV general sequences and of the two viral subtypes A and B were found in an HIV-1+ patient. It is concluded that it is not the localisation which predetermines NHLs to EBV-positivity but merely the underlying disease (this study) or the type of tumour (previous studies).
authors.affiliation: Pathologisches Institut, Universität Bern, Schweiz.
authors.forename: B
authors.initials: B
authors.lastname: Borisch
authors.forename: R
authors.initials: R
authors.lastname: Vonlanthen
authors.forename: R H
authors.initials: RH
authors.lastname: Laeng
authors.forename: S
authors.initials: S
authors.lastname: Kuehni
authors.forename: J A
authors.initials: JA
authors.lastname: Laissue
mesh_terms: D000956:Antigens, Viral / Q000032:analysis; D001483:Base Sequence; D017931:DNA Primers; D006679:HIV Seropositivity / Q000150:complications; D004854:Herpesvirus 4, Human / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D006801:Humans; D007150:Immunohistochemistry; D008214:Lymphocytes / Q000821:virology; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics / Q000473:pathology* / Q000821:virology*; D008969:Molecular Sequence Data; D009062:Mouth Neoplasms / Q000235:genetics / Q000473:pathology* / Q000821:virology*; D009856:Oncogene Proteins, Viral / Q000032:analysis; D016133:Polymerase Chain Reaction / Q000379:methods; D012680:Sensitivity and Specificity; D014763:Viral Matrix Proteins / Q000032:analysis
chemical_list: D000956:Antigens, Viral; D017931:DNA Primers; C037662:EBV-associated membrane antigen, Epstein-Barr virus; D009856:Oncogene Proteins, Viral; D014763:Viral Matrix Proteins