Genetic determinants of sense organ identity in Drosophila: regulatory interactions between cut and poxn.
Two genes involved in defining the type of sense organ have been identified in Drosophila. The gene cut differentiates the external sense organs (where it is expressed) from the chordotonal organs (where it is not); among the external sense organs poxn differentiates the poly-innervated organs (where it is expressed) from the mono-innervated organs (where it is not). Here we show that the expression of poxn in normal embryos does not depend on cut, and that poxn is capable of inducing the expression of cut. We have identified a small domain of the very large cut regulatory region as a likely target for activation by poxn.
Vervoort
M
M
Laboratoire de Génétique du Développement, Université Libre de Bruxelles, Belgium.
Zink
D
D
Pujol
N
N
Victoir
K
K
Dumont
N
N
Ghysen
A
A
Dambly-Chaudière
C
C
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D004330:Drosophila / Q000196:embryology / Q000235:genetics*; D029721:Drosophila Proteins; D005260:Female; D018507:Gene Expression Regulation, Developmental; D017344:Genes, Insect; D018398:Homeodomain Proteins; D007150:Immunohistochemistry; D007301:Insect Hormones / Q000235:genetics; D008297:Male; D009024:Morphogenesis / Q000235:genetics; D009419:Nerve Tissue Proteins / Q000235:genetics*; D009687:Nuclear Proteins / Q000235:genetics*; D051761:Paired Box Transcription Factors; D017933:Peripheral Nervous System / Q000196:embryology*; D012679:Sense Organs / Q000196:embryology*; D014157:Transcription Factors
D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D007301:Insect Hormones; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D051761:Paired Box Transcription Factors; C073863:Poxn protein, Drosophila; D014157:Transcription Factors; C066381:ct protein, Drosophila