Acute myelomonocytic leukemia in a patient with multiple myeloma: evidence for different clonal origin.
A case of 77-year-old female with multiple myeloma (IgG-k) developed acute myelomonocytic leukemia (AMMoL) following a myelodysplastic stage after chemotherapy with melphalancyclophosphamide combinations for 6 years. The leukemic blast cells expressed both myeloid antigens (CD11b, CD13, CD14, CD15, CD33 and CD34) and T/B lymphoid antigens (CD2, CD4, CD22 and PCA1). Cytogenetic analysis revealed a chromosome deletion -7. Analysis of immunoglobulin genes showed the heavy chain genes in germ line configuration. These findings indicate that the AMMoL was a therapy-related stem cell leukemia and was a clonal origin genetically different from multiple myeloma irrespective of plasma cell phenotype.
Nakase
K
K
Department of Internal Medicine, Yamada Red Cross Hospital, Mie.
Tsuji
K
K
Hasegawa
M
M
Suzuki
Y
Y
Tamaki
S
S
Tanigawa
M
M
Ikeda
T
T
Miyanishi
E
E
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D015479:Leukemia, Myelomonocytic, Acute / Q000188:drug therapy / Q000235:genetics* / Q000473:pathology; D009101:Multiple Myeloma / Q000150:complications* / Q000188:drug therapy / Q000235:genetics / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000235:genetics*