title: The association of urinary 5-hydroxyindoleacetic acid and vanillylmandelic acid in patients with generalized anxiety.
abstract: There is evidence that serotonin and norepinephrine are in some way involved in the pathophysiology of anxiety disorders. Urinary levels of the serotonin metabolite 5-hydroxyindoleacetic acid (5-HIAA) and the norepinephrine metabolite vanillylmandelic acid (VMA) were measured in 46 patients with generalized anxiety disorder. There was a significant association between urinary levels of 5-HIAA and VMA: r = 0.79; p = 0.0001. Possible implications of this finding are discussed.
authors.affiliation: Department of Psychiatry, VA Medical Center, Iowa City, Iowa 52246.
authors.forename: M J
authors.initials: MJ
authors.lastname: Garvey
authors.forename: R
authors.initials: R
authors.lastname: Noyes
authors.forename: C
authors.initials: C
authors.lastname: Woodman
authors.forename: C
authors.initials: C
authors.lastname: Laukes
mesh_terms: D001008:Anxiety Disorders / Q000503:physiopathology / Q000652:urine*; D005260:Female; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine*; D008297:Male; D008875:Middle Aged; D009638:Norepinephrine / Q000378:metabolism / Q000502:physiology; D012701:Serotonin / Q000378:metabolism / Q000502:physiology; D014642:Vanilmandelic Acid / Q000652:urine*
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; D009638:Norepinephrine