Cardiovascular responses to phenylephrine during acute experimental anaemia in anaesthetized cats.
Experiments were performed on anaesthetized artificially ventilated cats to study the effects of phenylephrine (PE) on cardiovascular responsiveness, before and after induction of experimental anaemia. Acute anaemia was induced by replacement of blood by dextran in three steps of 20% each of total estimated blood volume. The effect of PE (20 micrograms/kg) was investigated at four stages: control and after 1st, 2nd and 3rd exchanges of blood. Induction of anaemia produced a significant increase in heart rate (HR) and cardiac output (CO) and a decrease in right atrial pressure (RAP). No significant change in mean arterial pressure (MAP), LV dP/dt max and blood gas tension was observed. Administration of bolus dose of PE produced a rapid rise in MAP, LVdP/dt max, and a decrease in HR without a change in the RAP. The pattern of response to PE was similar after induction of acute anaemia, however the magnitude of the response was significantly reduced. The attenuation in the response to PE was related to the fall in the haematocrit (HCT) level. This shows that induction of experimental anaemia, produced an increase in CO due to an increase in HR and SV and the effect of PE on cardiovascular responsiveness was significantly attenuated. The reduced sensitivity to PE during acute anaemia could be due to many factors such as inadequate O2 supply, effect of local vasodilating agents or some other cardiotonic agents which are known to contribute to vascular responsiveness.
Talwar
A
A
Department of Physiology, Vallabhbhai Patel Chest Institute, University of Delhi.
Hussain
M E
ME
Gupta
C K
CK
Fahim
M
M
D000208:Acute Disease; D000704:Analysis of Variance; D000740:Anemia / Q000139:chemically induced / Q000503:physiopathology*; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D001802:Blood Substitutes / Q000008:administration & dosage / Q000633:toxicity; D001810:Blood Volume / Q000187:drug effects; D002302:Cardiac Output / Q000187:drug effects*; D002415:Cats; D003911:Dextrans / Q000008:administration & dosage / Q000633:toxicity; D004195:Disease Models, Animal; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006400:Hematocrit; D006438:Hemodilution / Q000009:adverse effects; D008297:Male; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*
D001802:Blood Substitutes; D003911:Dextrans; D010656:Phenylephrine