Mathematical description of transport of water and macromolecules through the glomerular capillary wall.
Glomerular diseases are associated with changes in glomerular membrane permeability properties that alter filtration rate of plasma water and barrier function of the capillary wall. To estimate intrinsic permeability properties that regulate transmembrane transport of water and macromolecules, theoretical analysis of renal clearance of tracer molecules can be used. The development of adequate theoretical models is required to achieve sufficient accuracy to simulate complicated biological processes. Current research in this area is aimed at improving and validating the presently available models in order to characterize the nature of permeability changes associated with pathological conditions. This is a key step in understanding the pathophysiological nature of glomerular diseases and in the development of effective treatments.
Remuzzi
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Biomedical Engineering Laboratory, Mario Negri Institute for Pharmacological Research, Bergamo, Italy.
D000818:Animals; D001693:Biological Transport, Active; D001834:Body Water / Q000378:metabolism*; D002196:Capillaries / Q000378:metabolism; D006801:Humans; D007678:Kidney Glomerulus / Q000098:blood supply / Q000378:metabolism*; D008954:Models, Biological; D012079:Renal Circulation / Q000502:physiology*