title: Fetal biophysical profile and vibratory acoustic stimulation in high-risk pregnancies.
abstract: OBJECTIVE
  To determine the influence of the non-stress test (NST) on the efficiency of the fetal biophysical profile (FBP) and to test the clinical usefulness of the FBP and its combination with vibratory acoustic stimulation (VAS) in managing high-risk pregnancies.
  
  
  METHODS
  One hundred twenty fetuses of preeclamptic patients were included in a prospective study. Five standard variables of the FBP were observed ultrasonically following NST. In cases of non-reactive NST, external VAS was applied and the FBP score calculated and compared with the FBP score before VAS.
  
  
  RESULTS
  Of 120 calculated FBPs, 102 (85%) had normal profile scores before VAS and 104 (86.7%) after VAS. No statistically significant difference was found. The sensitivity, specificity, and positive and negative predictive values of the FBP score in predicting poor perinatal outcome were 94.7%, 94.4%, 75% and 99%, respectively. VAS produced a high conversion (58.8%) of non-reactive NST to reactive fetal heart rate pattern. The false-negative rate of the FBP score was 9.8 per 1000, which did not increase after VAS.
  
  
  CONCLUSIONS
  The efficiency of the FBP score was not significantly improved by VAS, although a high conversion of non-reactive to reactive NST was produced. The FBP with its three 'acute biophysical variables' was found to be an accurate method of antepartum assessment even without an NST. The low incidence of perinatal complications among patients with normal FBP scores, permits the conservative management of preterm high-risk pregnancies.
authors.affiliation: Department of Obstetrics and Gynecology, University of Rijeka, Croatia.
authors.forename: O
authors.initials: O
authors.lastname: Petrović
authors.forename: A
authors.initials: A
authors.lastname: Frković
authors.forename: N
authors.initials: N
authors.lastname: Matejcić
mesh_terms: D000161:Acoustic Stimulation; D005260:Female; D005315:Fetal Diseases / Q000503:physiopathology* / Q000628:therapy*; D006801:Humans; D011225:Pre-Eclampsia; D011247:Pregnancy; D011256:Pregnancy Outcome; D018566:Pregnancy, High-Risk; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016216:Ultrasonography, Prenatal