title: Fluid and protein secretion by the submandibular glands of weanling rats in response to various agonists.
abstract: Secretion of fluid and protein by the submandibular glands of 25-day-old rats was investigated by stimulation with 22 sialogogues classified into five categories, four cholinergic, five beta 1-, seven alpha 1- and three alpha 2-adrenergic, and three peptidergic, at optimal doses. For fluid secretion, cholinergic and peptidergic agonists were the most powerful, whereas the beta 1- and alpha 1-adrenoceptor agonists were the most effective for the concentration of protein among the five categories, except for methoxamine. For total output of protein, the beta 1- and alpha 1-adrenoceptor agonists and pilocarpine were the most powerful among the 22 agonists, except for methoxamine and norephedrine. Cholinergic, peptidergic and alpha 2-adrenergic agonists among the five categories were less effective for protein secretion, except for pilocarpine. For the specific activity of esteroprotease, methoxamine and oxymetazoline, as alpha-adrenoceptor agonists, were the most powerful among the 22 agonists. Thus fluid and protein secretion evoked from the submandibular glands of weanling rats in response to a wide variety of agonists are similar to those of adult rats.
authors.affiliation: Department of Pediatric Dentistry, Fukuoka Dental College, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Baba
authors.forename: K
authors.initials: K
authors.lastname: Taniguchi
authors.forename: W
authors.initials: W
authors.lastname: Motokawa
authors.forename: K
authors.initials: K
authors.lastname: Abe
mesh_terms: D000322:Adrenergic Agonists / Q000494:pharmacology; D000818:Animals; D018679:Cholinergic Agonists / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012463:Saliva / Q000201:enzymology / Q000378:metabolism; D012471:Salivary Proteins and Peptides / Q000819:agonists*; D012472:Salivation / Q000187:drug effects* / Q000502:physiology; D012697:Serine Endopeptidases / Q000819:agonists; D013268:Stimulation, Chemical; D013363:Submandibular Gland / Q000187:drug effects* / Q000378:metabolism; D013373:Substance P / Q000494:pharmacology; D014886:Weaning
chemical_list: D000322:Adrenergic Agonists; D018679:Cholinergic Agonists; D012471:Salivary Proteins and Peptides; D013373:Substance P; C044499:submandibular proteinase A; D012697:Serine Endopeptidases