title: Substance P binding in normal neonatal foreskin.
abstract: The distribution of binding sites for NTE-biotinyl-[Arg3]-substance P (SPB) was demonstrated in neonatal foreskin using a conjugate of streptavidin with horseradish peroxidase. The observed binding is reversible, and may be abrogated by either the non-peptide substance P receptor antagonist, CP-96,345, or by unlabelled substance P. The generalized epidermal distribution and focal dermal localization of SPB binding suggest that although NK-1 receptors are abundant in human neonatal foreskin, neuromodulatory mechanisms may play a significant role in epidermal physiology.
authors.affiliation: Department of Dermatovenereology, Charles University School of Medicine, Prague, Czech Republic.
authors.forename: P
authors.initials: P
authors.lastname: Arenberger
authors.forename: R O
authors.initials: RO
authors.lastname: Leder
authors.forename: A
authors.initials: A
authors.lastname: Abraham
authors.forename: J K
authors.initials: JK
authors.lastname: Chang
authors.forename: E M
authors.initials: EM
authors.lastname: Farber
mesh_terms: D001665:Binding Sites; D006801:Humans; D007124:Immunoenzyme Techniques; D007231:Infant, Newborn; D008297:Male; D010413:Penis / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*; D013545:Sweat Glands / Q000378:metabolism
chemical_list: D013373:Substance P