Does the transcription factor c-ets1 take part in the regulation of angiogenesis and tumor invasion?
The c-ets1 proto-oncogene encodes a transcription factor that binds a GGAA/T purine rich core DNA sequence. During normal as well as pathological development, the expression of c-ets1 is associated with the occurrence of invasive processes, either in invading cells or in the invaded tissue. Cellular regulatory sequences responsive to the c-Ets1 proteins include a urokinase-type plasminogen activator (u-PA) gene enhancer, the stromelysin-1 and the collagenase-1 gene promoters. Since invasive processes are thought to require the remodeling of the extra-cellular matrix, we investigate the relationships between c-Ets1 and the expression pattern of transcripts encoding these matrix degrading proteases, in embryos and in solid tumors.
Vandenbunder
B
B
Laboratoire d'Oncologie Moléculaire, CNRS-URA 1160, Institut Pasteur de Lille, France.
Wernert
N
N
Queva
C
C
Desbiens
X
X
Stehelin
D
D
D009389:Neovascularization, Pathologic / Q000503:physiopathology; D050784:Proto-Oncogene Protein c-ets-1; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism*; D050783:Proto-Oncogene Proteins c-ets; D011519:Proto-Oncogenes / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
D050784:Proto-Oncogene Protein c-ets-1; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors