title: Truncal vagotomy does not affect postabsorptive glucose metabolism in humans.
abstract: To evaluate the effects of hepatic vagal denervation on the adaptation of glucose metabolism to short-term starvation (i.e., < 24 h), glucose metabolism was studied after 16 and again after 22 h of fasting in postsurgical patients with truncal vagotomy (n = 9; radical resection of esophageal carcinoma) and without truncal vagotomy (n = 5; partial resection of the large bowel for carcinoma). Glucose metabolism was studied 3-7.5 mo postoperatively by [3-3H]glucose turnover and by indirect calorimetry. Basal glucose production, plasma glucose concentration, glucose oxidation, serum free fatty acid concentration, and fat oxidation were not different between groups; neither were plasma concentrations of glucoregulatory hormones. The adaptation to prolongation of the fast by 6 h was not different for any of these parameters between both groups. In conclusion, truncal vagotomy does not affect the adaptation of glucose metabolism to the postabsorptive state (16-22 h of fasting).
authors.affiliation: Department of Endocrinology, University of Amsterdam, The Netherlands.
authors.forename: E P
authors.initials: EP
authors.lastname: Corssmit
authors.forename: J J
authors.initials: JJ
authors.lastname: Van Lanschot
authors.forename: J A
authors.initials: JA
authors.lastname: Romijn
authors.forename: E
authors.initials: E
authors.lastname: Endert
authors.forename: H P
authors.initials: HP
authors.lastname: Sauerwein
mesh_terms: D000368:Aged; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D005260:Female; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D015167:Vagotomy, Truncal
chemical_list: D005230:Fatty Acids, Nonesterified; D005947:Glucose