title: The cell biology of CTL killing.
abstract: A great deal is known about the immunology of cytotoxic T lymphocyte killing, but much less is known about the cell biology of this process. Recent work has begun to elucidate the mechanisms that control lytic-protein secretion, and reveals that some unusual features of these secretory processes might explain some of the important features of killing by cytotoxic T lymphocytes.
authors.affiliation: Basel Institute for Immunology, Basel, Switzerland.
authors.forename: G M
authors.initials: GM
authors.lastname: Griffiths
mesh_terms: D017209:Apoptosis; D002450:Cell Communication / Q000276:immunology; D003594:Cytoplasmic Granules; D003602:Cytotoxicity, Immunologic; D004705:Endocytosis; D000939:Epitopes; D006801:Humans; D018448:Models, Immunological; D015388:Organelles / Q000276:immunology / Q000502:physiology; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000502:physiology; D015398:Signal Transduction; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology* / Q000502:physiology
chemical_list: D000939:Epitopes; D011948:Receptors, Antigen, T-Cell