Hypergammaglobulinemic purpura of Waldenstrom associated with systemic lupus erythematosus: report of a case and review of the literature.
A patient with hyperglobulinemic purpura of Waldenstrom and systemic lupus erythematosus is reported. The coexistence of these two conditions which share a number of common clinical and laboratory features is rare. Treatment of the patient with prednisone, colchicine and hydroxychloroquine led to the improvement of the cutaneous vasculitis and a drop in ESR, serum gamma globulins and IgM and IgG rheumatoid factors. The features of nine other cases and the immunopathogenesis of the disease are reviewed.
Habib
G S
GS
University of Southern California, Department of Medicine, Los Angeles, USA.
Stimmer
M M
MM
Quismorio
F P
FP
D000328:Adult; D003078:Colchicine / Q000627:therapeutic use; D005260:Female; D006801:Humans; D006886:Hydroxychloroquine / Q000627:therapeutic use; D007074:Immunoglobulin G / Q000097:blood; D007075:Immunoglobulin M / Q000097:blood; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use; D012217:Rheumatoid Factor / Q000097:blood; D012867:Skin / Q000098:blood supply; D014657:Vasculitis / Q000628:therapy; D008258:Waldenstrom Macroglobulinemia / Q000097:blood / Q000150:complications* / Q000188:drug therapy; D005719:gamma-Globulins / Q000378:metabolism
D007074:Immunoglobulin G; D007075:Immunoglobulin M; D005719:gamma-Globulins; D006886:Hydroxychloroquine; D012217:Rheumatoid Factor; D003078:Colchicine; D011241:Prednisone