[Antineoplastic chemotherapy in metastatic Wilm's tumor].
Wilms tumors may, rarely, also occur in adulthood. A 32-year-old male who, following the removal of a Wilms tumor, developed recurrent disease and metastases to the lungs and liver, was treated with a polychemotherapeutic regimen. Primarily, this was based on the protocol usually applied in children that comprises a combination of actinomycin D, vincristine, and adriamycin. Treatment initially achieved a six-month partial remission. Further treatment became necessary when a recurrence again occurred, and resulted in a "no change" situation that lasted for two months. The subsequent deterioration of the patient prompted monotherapy with vincristine, resulting in a transient clinical improvement. The patient finally died 25 months and two weeks after chemotherapy was first initiated.
Quietzsch
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Onkologische Abteilung, Klinik für Innere Medizin Küchwald des Klinikums Chemnitz gGmbH, Universität Leipzig.
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D017024:Chemotherapy, Adjuvant; D003131:Combined Modality Therapy; D003609:Dactinomycin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007680:Kidney Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy / Q000601:surgery; D008113:Liver Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D008175:Lung Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery; D008297:Male; D014750:Vincristine / Q000008:administration & dosage; D009396:Wilms Tumor / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary* / Q000601:surgery
D003609:Dactinomycin; D014750:Vincristine; D004317:Doxorubicin