title: Fat in the prediction of bone strength of porcine lumbar vertebrate by quantitative computed tomography.
abstract: The influence of fat content on quantitative computed tomography (QCT) values was studied using porcine lumbar vertebrae as a model. A total of 72 cancellous bone columns, prepared from 18 vertebrae, underwent QCT examination before and after defatting. Mechanical testing and ashing were performed to obtain the ultimate strength and bone mineral content. The ultimate strength was calculated as a power function of apparent density using linear regression on a log-log plot and the power coefficient was 1.88. QCT values were positively correlated with bone density. QCT values of defatted specimens correlated much better with ultimate strength than those of fresh specimens. The average fat content was 27.2%. The QCT values decreased linearly with increasing fat content with a slope of 7.9 mg/cm3/% fat and a correlation coefficient of 0.65. The results provided basic data for the calibration of the machine and the principles for the interpretation of QCT values excluding the fat influence.
authors.affiliation: Department of Radiology, National Cheng Kung University Medical Center, Tainan, Taiwan ROC.
authors.forename: C Y
authors.initials: CY
authors.lastname: Yu
authors.forename: R M
authors.initials: RM
authors.lastname: Lin
authors.forename: K H
authors.initials: KH
authors.lastname: Tsai
authors.forename: G L
authors.initials: GL
authors.lastname: Chang
mesh_terms: D000818:Animals; D015519:Bone Density; D005223:Fats / Q000032:analysis*; D005260:Female; D008159:Lumbar Vertebrae / Q000737:chemistry / Q000502:physiology*; D013552:Swine; D013718:Tensile Strength; D014057:Tomography, X-Ray Computed
chemical_list: D005223:Fats