title: Mucinous adenocarcinomas of the vulva.
abstract: An 80-year-old nullipara had a 2.0-cm cystic tumor of the right labium majus. Histologic diagnosis was mucinous eccrine carcinoma. Seventy-five percent of these rare skin adnexal tumors arise on the face, eyelid, or scalp; but none has been reported on the vulva. Indolent localized growth is usual with regional nodal spread in 11% and distant metastases in 3%. A 67-year-old multipara had a 1.2-cm polypoidal nodule of the posterior fourchette. Histologically, a colonic type mucinous carcinoma was arising within a villous adenoma. Mucicarmine and CEA stains were positive. Extensive workup failed to reveal other primary cancers in either patient. Both patients are well 19 and 17 months after radical vulvectomies and node-negative groin dissections. These cases illustrate further the diversity in cell type and biologic behavior of vulvar adenocarcinomas.
authors.affiliation: Department of Obstetrics and Gynecology, Boston University School of Medicine, Massachusetts 02215, USA.
authors.forename: S A
authors.initials: SA
authors.lastname: Ghamande
authors.forename: J
authors.initials: J
authors.lastname: Kasznica
authors.forename: C T
authors.initials: CT
authors.lastname: Griffiths
authors.forename: N J
authors.initials: NJ
authors.lastname: Finkler
authors.forename: A M
authors.initials: AM
authors.lastname: Hamid
mesh_terms: D002288:Adenocarcinoma, Mucinous / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*; D000368:Aged; D000369:Aged, 80 and over; D002272:Carcinoembryonic Antigen / Q000032:analysis; D002329:Carmine; D004396:Coloring Agents / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D013194:Staining and Labeling; D014846:Vulvar Neoplasms / Q000737:chemistry / Q000175:diagnosis / Q000473:pathology*
chemical_list: D002272:Carcinoembryonic Antigen; D004396:Coloring Agents; C029618:mucicarmine; D002329:Carmine