Pharmacokinetics of analgesics, sedatives and anaesthetic agents during cardiopulmonary bypass.
CPB produces changes in the blood-gas partition coefficient dependent on the prime used and temperature. Fortunately, the overall effect for hypothermic CPB and a crystalloid prime is only +2%. A volatile agent started during hypothermic CPB takes longer to equilibrate and agents already in use need to re-equilibrate, potentially changing the depth of anaesthesia, until equilibration is complete. As these agents are metabolized to a small degree and washout is fast, the duration of action is not prolonged after CPB.
Gedney
J A
JA
Department of Anaesthesia, Addenbrooke's Hospital, Cambridge.
Ghosh
S
S
D000701:Analgesics, Opioid / Q000493:pharmacokinetics*; D000777:Anesthetics / Q000493:pharmacokinetics*; D001569:Benzodiazepines / Q000493:pharmacokinetics; D002315:Cardiopulmonary Bypass; D006801:Humans; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics*
D000701:Analgesics, Opioid; D000777:Anesthetics; D006993:Hypnotics and Sedatives; D001569:Benzodiazepines