title: Anti-oedematous action of some H1-receptor antagonists.
abstract: The oedema disk technique was used to study the effects of orally administered H1-receptor antagonists (cetirizine, chloropyramine, clemastine, cyproheptadine, dimethindene, loratadine, mequitazine and terfenadine) on the inflammation induced with capsaicin or croton oil in the mouse ear, and the effect of topically applied dimethindene maleate gel on the inflammation induced with croton oil in the mouse ear. In rats of the Wistar strain, oedema was induced in the hind paw by the subplantar injection of dextran or compound 48/80. Preliminary antihistamine treatment inhibited the development of oedema in the mouse ear, and of oedema in the rat paw, to statistically significant extents, in a dose-dependent manner. In all experiments, the most potent drugs were loratadine and cyproheptadine.
authors.affiliation: Institute of Pharmacodynamics, Albert Szent-Györgyi, Medical University, Szeged, Hungary.
authors.forename: G
authors.initials: G
authors.lastname: Blazsó
authors.forename: M
authors.initials: M
authors.lastname: Gábor
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002211:Capsaicin; D003436:Croton Oil; D003911:Dextrans / Q000494:pharmacology; D004115:Dimethindene; D004431:Ear, External / Q000473:pathology; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D005528:Foot / Q000473:pathology; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003911:Dextrans; D006634:Histamine H1 Antagonists; D003189:p-Methoxy-N-methylphenethylamine; D004115:Dimethindene; D003436:Croton Oil; D002211:Capsaicin