Single dose ceftriaxone versus single dose cefuroxime plus metronidazole for preventing febrile morbidity and urinary tract infection in vaginal hysterectomy.
OBJECTIVE
To compare the prophylactic efficacy of 1 g ceftriaxone with 1.5 g cefuroxime + 0.5 g metronidazole for febrile morbidity and urinary tract infection in patients undergoing vaginal hysterectomy.


METHODS
A prospective, randomized, comparative, non-blinded study with at least 100 patients on each side. The two-sample t-test was used for testing equality of two means and the chi 2 test was used for pair differences.


RESULTS
Single dose cefuroxime + metronidazole and ceftriaxone were equally effective in preventing febrile morbidity postoperatively. Additionally ceftriaxone was more effective in sterilizing pre-operatively existing bacteriuria.
Brouwer
W K
WK
Department of Obstetrics and Gynaecology, Medical Center Leeuwarden, The Netherlands.
Hoogkamp Korstanje
J A
JA
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000994:Antitrichomonal Agents / Q000008:administration & dosage / Q000627:therapeutic use; D002443:Ceftriaxone / Q000008:administration & dosage / Q000627:therapeutic use*; D002444:Cefuroxime / Q000008:administration & dosage / Q000627:therapeutic use*; D002511:Cephalosporins / Q000008:administration & dosage / Q000627:therapeutic use; D016983:Enterococcus / Q000302:isolation & purification; D004926:Escherichia coli / Q000302:isolation & purification; D005260:Female; D005334:Fever / Q000517:prevention & control*; D006801:Humans; D007044:Hysterectomy / Q000009:adverse effects*; D008795:Metronidazole / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000382:microbiology / Q000517:prevention & control*
D000994:Antitrichomonal Agents; D002511:Cephalosporins; D008795:Metronidazole; D002443:Ceftriaxone; D002444:Cefuroxime