title: Regulation of sugar transport via the multiple sugar metabolism operon of Streptococcus mutans by the phosphoenolpyruvate phosphotransferase system.
abstract: In this report, we provide evidence that the transport of sugars in Streptococcus mutans via the multiple sugar metabolism system is regulated by the phosphoenolpyruvate phosphotransferase system. A ptsI-defective mutant (DC10), when grown on the multiple sugar metabolism system substrate raffinose, exhibited reduced growth, transport, and glycolytic activity with raffinose relative to the parent strain BM71. Inhibition of [3H]raffinose uptake was also observed in both BM71 and DC10 with increasing concentrations of glucose and the glucose analogs alpha-methyl glucoside and 2-deoxyglucose.
authors.affiliation: Department of Oral Biology, Faculty of Dentistry, University of Manitoba, Winnipeg, Canada.
authors.forename: D G
authors.initials: DG
authors.lastname: Cvitkovitch
authors.forename: D A
authors.initials: DA
authors.lastname: Boyd
authors.forename: I R
authors.initials: IR
authors.lastname: Hamilton
mesh_terms: D001693:Biological Transport, Active; D005947:Glucose / Q000378:metabolism*; D006019:Glycolysis; D009876:Operon; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000502:physiology*; D011887:Raffinose / Q000378:metabolism*; D013295:Streptococcus mutans / Q000254:growth & development / Q000378:metabolism*
chemical_list: D010731:Phosphoenolpyruvate Sugar Phosphotransferase System; D005947:Glucose; D011887:Raffinose