title: [Frequency of gastroesophageal reflux in infants and in young children with cystic fibrosis].
abstract: BACKGROUND
  Gastro-esophageal reflux (GER) is common in chronic bronchopulmonary diseases, and may aggravate them. The aim of this study was to study frequency and characteristics of GER in infants and toddlers with cystic fibrosis (CF).
  
  
  METHODS
  Twenty-five CF patients, 45 to 954 days-old (mean 219 days) without clinical evidence of bronchopulmonary infection, were studied by prolonged pHmetry (19.45 +/- 1.89 hours). Their pulmonary state was evaluated by the number of previous courses of antibiotic treatment and analysis of the X-rays.
  
  
  RESULTS
  Nineteen children had GER (76%); four of them had no clinical sign of GER. All 19 patients had mild or moderate signs of pulmonary impairment. The reflux index (percentage of time with pH < 4) was 12.82%. The GER episodes were more frequent during walking time (p < 0.001), but longer during sleeping time (p < 0.001).
  
  
  CONCLUSIONS
  GER is frequent in CF patients, even the youngest. It seems primary, and not related to pulmonary impairment. Its frequency and its potential severity lead to suggesting a pHmetry to every new CF patient.
authors.affiliation: Service de pédiatrie, hôpital Huriez, Lille, France.
authors.forename: P
authors.initials: P
authors.lastname: Vic
authors.forename: E
authors.initials: E
authors.lastname: Tassin
authors.forename: D
authors.initials: D
authors.lastname: Turck
authors.forename: F
authors.initials: F
authors.lastname: Gottrand
authors.forename: V
authors.initials: V
authors.lastname: Launay
authors.forename: J P
authors.initials: JP
authors.lastname: Farriaux
mesh_terms: D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000150:complications*; D005764:Gastroesophageal Reflux / Q000175:diagnosis / Q000453:epidemiology* / Q000209:etiology*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007223:Infant