CHUK, a conserved helix-loop-helix ubiquitous kinase, maps to human chromosome 10 and mouse chromosome 19.
Helix-loop-helix proteins contain stretches of DNA that encode two amphipathic alpha-helices joined by a loop structure and are involved in protein dimerization and transcriptional regulation essential to a variety of cellular processes. CHUK, a newly described conserved helix-loop-helix ubiquitous kinase, was mapped by somatic cell hybrid analyses to human Chr 10q24-q25. Chuk and a related sequence, Chuk-rs1, were mapped to mouse chromosomes 19 and 16, respectively, by a combination of somatic cell hybrid, recombinant inbred, and backcross analyses.
Mock
B A
BA
Laboratory of Genetics and Biochemistry, NCI, NIAID, National Institutes of Health, Bethesda, Maryland 20892, USA.
Connelly
M A
MA
McBride
O W
OW
Kozak
C A
CA
Marcu
K B
KB
D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D002879:Chromosomes, Human, Pair 10; D006224:Cricetinae; D018076:DNA, Complementary / Q000737:chemistry; D018257:Helix-Loop-Helix Motifs / Q000235:genetics*; D006801:Humans; D051550:I-kappa B Kinase; D016350:Leucine Zippers / Q000235:genetics*; D051379:Mice; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*
D018076:DNA, Complementary; D017346:Protein Serine-Threonine Kinases; C496559:CHUK protein, human; C496564:Chuk protein, mouse; D051550:I-kappa B Kinase; C496560:IKBKB protein, human; C496565:IKBKE protein, human; C496562:Ikbkb protein, mouse; C496566:Ikbke protein, mouse