Inhibition of simian immunodeficiency virus (SIV) replication by CD8+ cells of SIV-infected rhesus macaques: implications for immunopathogenesis.
The ability of the CD8+ cells from simian immunodeficiency virus (SIV)-infected rhesus macaques to inhibit SIV replication was investigated. Inhibition was produced by a heat-stable soluble factor of molecular size greater than 10kDa. CD8+ supernatants from some macaques were found not only to suppress SIV growth but also to be cytolytic toward both infected and uninfected CD4+ cells. Such indiscriminate CD8+ cell-mediated cell killing may therefore account for DC4+ cell depletion in certain SIV-infected macaques.
Blackbourn
D J
DJ
Department of Medical Pharmacology and Toxicology, School of Medicine, University of California, Davis 95616.
Chuang
L F
LF
Killam
K F
KF
Chuang
R Y
RY
D000818:Animals; D001685:Biological Factors / Q000276:immunology / Q000302:isolation & purification; D018414:CD8-Positive T-Lymphocytes / Q000276:immunology* / Q000821:virology; D002470:Cell Survival; D008253:Macaca mulatta; D008297:Male; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism; D012016:Reference Values; D016097:Simian Acquired Immunodeficiency Syndrome / Q000276:immunology*; D015302:Simian Immunodeficiency Virus / Q000502:physiology*; D014779:Virus Replication
D001685:Biological Factors; D012194:RNA-Directed DNA Polymerase