title: Acyclovir-induced neutropenia in an infant with herpes simplex encephalitis: case report.
abstract: A newborn infant whose condition was diagnosed as herpes simplex encephalitis and who had subsequent recurrences of skin disease had repeated episodes of neutropenia while receiving therapy with intravenous (30 mg/[kg.d]) or oral (30 mg/]kg.d]) acyclovir. The neutropenia did not recur when the dosage of oral acyclovir was reduced to 10 mg/(kg.d). This case represents the first well-documented report of acyclovir-induced neutropenia.
authors.affiliation: Department of Pediatrics and Family Medicine, University of Connecticut Health Center, Farmington 06030-3960, USA.
authors.forename: H M
authors.initials: HM
authors.lastname: Feder
authors.forename: R K
authors.initials: RK
authors.lastname: Goyal
authors.forename: P J
authors.initials: PJ
authors.lastname: Krause
mesh_terms: D000212:Acyclovir / Q000009:adverse effects* / Q000627:therapeutic use; D018792:Encephalitis, Viral / Q000134:cerebrospinal fluid / Q000150:complications / Q000188:drug therapy* / Q000821:virology; D005260:Female; D005500:Follow-Up Studies; D018258:Herpesvirus 2, Human / Q000187:drug effects; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D009503:Neutropenia / Q000134:cerebrospinal fluid / Q000139:chemically induced* / Q000150:complications
chemical_list: D000212:Acyclovir