[The morphofunctional characteristics of the heart under the joint action of hexachlorane and physical loading of varying intensity].
In the experiments, performed in 125 male Wistar rats the animals were sacrificed by oral treatment with 1/20 LD50 of pesticide hexachloran with the simultaneous modelling of physical load of 3 levels (minimum, medium, maximum). Horizontal treadmill was used to obtain the dynamic load. Duration of experiment made 30 days. The data obtained demonstrated the direct cardiotropic effect of the drug Dynamic loads of the medium and maximum levels amplify the toxic effect, leading to the hypertrophy of the left heart, decrease of the coefficient of the mitochondrial energetic efficiency, aerobic oxidation and growth of the contracture myocardial degeneration and aerobic glycolysis.
Kolbasin
P H
PH
Shkodivskiĭ
N I
NI
Lazarev
K L
KL
D000818:Animals; D004734:Energy Metabolism / Q000187:drug effects; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006439:Hemodynamics / Q000187:drug effects; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000648:ultrastructure; D009929:Organ Size / Q000187:drug effects; D005082:Physical Exertion / Q000187:drug effects* / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D001556:Hexachlorocyclohexane