title: Recurrence of hepatitis B virus cirrhosis and hepatocellular carcinoma: an indication for retransplantation?
abstract: Hepatitis B virus reinfection as well as recurrence of hepatocellular carcinoma are frequent complications in liver allograft recipients. This is the report of a patient who had two liver transplantations with a 6-year interval, both for the same indication-postnecrotic cirrhosis and liver cancer. Following first and second transplantation, hepatitis B reinfection occurred at 12 and 6 months, and allograft cirrhosis developed after 20 and 10 months, respectively. Intrahepatic recurrence of hepatocellular carcinoma was found after 69 months. Two years following retransplantation, the patient is tumor-free, and has normal graft function. In selected patients with hepatitis B-related liver disease, and hepatocellular carcinoma liver replacement is indicated when combined with effective immunoprophylaxis, and other adjuvant therapy. Late recurrence of both diseases is unusual, and retransplantation may come into question.
authors.affiliation: Klinik für Abdominal- und Transplantationschirurgie, Medizinische Hochschule Hannover, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Ringe
authors.forename: K
authors.initials: K
authors.lastname: Böker
authors.forename: H J
authors.initials: HJ
authors.lastname: Schlitt
authors.forename: J
authors.initials: J
authors.lastname: Sproviero
authors.forename: J
authors.initials: J
authors.lastname: Hundrieser
authors.forename: H L
authors.initials: HL
authors.lastname: Tillmann
authors.forename: A
authors.initials: A
authors.lastname: Chavan
authors.forename: P
authors.initials: P
authors.lastname: Flemming
authors.forename: M
authors.initials: M
authors.lastname: Galanski
authors.forename: R
authors.initials: R
authors.lastname: Pichlmayr
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000601:surgery*; D006509:Hepatitis B / Q000150:complications / Q000601:surgery*; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications / Q000601:surgery* / Q000821:virology; D008113:Liver Neoplasms / Q000150:complications / Q000601:surgery*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D012008:Recurrence; D012086:Reoperation