Alteration of brain nicotinic receptors induced by immobilization stress and nicotine in rats.
Immobilization stress (2 h.day-1, for 2 weeks) caused downregulation of the nicotinic receptors ([3H]cytisine binding sites) in the rat brain (cerebral cortex and midbrain). However, chronic nicotine treatment abrogated stress induced downregulation of the [3H]cytisine binding sites, suggesting that chronic nicotine treatment may block stress activated nicotinic receptor-mediated neurotransmission.
Takita
M
M
Department of Pharmacology, Fukui Medical School, Japan.
Muramatsu
I
I
D000470:Alkaloids / Q000378:metabolism; D000818:Animals; D001392:Azocines; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D015536:Down-Regulation / Q000187:drug effects; D007103:Immobilization; D008024:Ligands; D008297:Male; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D009538:Nicotine / Q000494:pharmacology*; D018722:Nicotinic Agonists / Q000494:pharmacology*; D011807:Quinolizines; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011978:Receptors, Nicotinic / Q000187:drug effects* / Q000378:metabolism*; D013315:Stress, Psychological / Q000378:metabolism*; D000093843:Quinolizidine Alkaloids
D000470:Alkaloids; D001392:Azocines; D008024:Ligands; D009538:Nicotine; D018722:Nicotinic Agonists; D011807:Quinolizines; D011813:Quinuclidinyl Benzilate; D011978:Receptors, Nicotinic; C004712:cytisine; D000093843:Quinolizidine Alkaloids