title: The influence of gene deletions and duplications within the IGHC locus on serum immunoglobulin subclass levels.
abstract: To study the influence of heterozygous gene deletions and duplications in the human IGHC region on serum concentrations of antibodies, we have analyzed the IgG subclass levels in a large number of individuals from three different populations. Our results show that heterozygous gene deletions of the C gamma 1, C gamma 2, or C gamma 4 genes are all associated with a lower mean serum level of the affected subclass whereas duplication of the C gamma 2 or C gamma 4 genes result in either no change (IgG2) or a slightly elevated (IgG4) level of serum immunoglobulins.
authors.affiliation: Center for BioTechnology, Karolinska Institute, NOVUM, Huddinge, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Rabbani
authors.forename: N
authors.initials: N
authors.lastname: Kondo
authors.forename: C I
authors.initials: CI
authors.lastname: Smith
authors.forename: L
authors.initials: L
authors.lastname: Hammarström
mesh_terms: D017353:Gene Deletion; D005803:Genes, Immunoglobulin / Q000235:genetics*; D006801:Humans; D007070:Immunoglobulin A / Q000097:blood; D007074:Immunoglobulin G / Q000097:blood* / Q000145:classification* / Q000235:genetics; D007075:Immunoglobulin M / Q000097:blood; D005810:Multigene Family / Q000276:immunology*
chemical_list: D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M