Microbial transformation of immunosuppressive compounds. IV. Hydroxylation and hemiketal formation of ascomycin (immunomycin) by Streptomyces sp. MA 6970 (ATCC No. 55281).
Chen
T S
TS
Merck Research Laboratory, Rahway, New Jersey 07065.
Petuch
B
B
White
R
R
Dezeny
G
G
Li
X
X
Arison
B
B
Beattie
T
T
Colwell
L
L
Dumont
F
F
Monaghan
R
R
D001711:Biotransformation; D005285:Fermentation; D006900:Hydroxylation; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D013302:Streptomyces / Q000378:metabolism*; D016559:Tacrolimus / Q000031:analogs & derivatives* / Q000737:chemistry / Q000378:metabolism
D007166:Immunosuppressive Agents; C058028:immunomycin; D016559:Tacrolimus