Plasma granulocyte colony stimulating factor concentrations in pregnant women.
We measured the plasma granulocyte colony stimulating factor (G-CSF) concentrations in pregnant women to evaluate the association between G-CSF and increased neutrophil counts that has been observed during pregnancy. We examined 96 pregnant and 10 nonpregnant women. The G-CSF concentrations were assayed using a sandwich enzyme immunoassay. The G-CSF concentrations in pregnant women were significantly higher at all times than those of nonpregnant women. The G-CSF concentrations were also significantly higher during than before labor. The plasma G-CSF concentrations were positively correlated with the neutrophil counts during the 3rd trimester only. In conclusion, increased G-CSF concentrations may be related to the increases in neutrophil counts in pregnant women, especially during the 3rd trimester.
Umesaki
N
N
Department of Obstetrics and Gynecology, Osaka City University Medical School, Japan.
Fukumasu
H
H
Miyama
M
M
Kawabata
M
M
Ogita
S
S
D000328:Adult; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood*; D006801:Humans; D007124:Immunoenzyme Techniques; D007958:Leukocyte Count; D009504:Neutrophils; D011247:Pregnancy / Q000097:blood*; D011263:Pregnancy Trimester, Third
D016179:Granulocyte Colony-Stimulating Factor