title: [Pathogenesis of severe influenza].
abstract: The paper analyzes the contribution of active oxygen radicals whose formation was observed in the inflammatory foci, as well as in generalized influenza infection. There is a correlation between the inactivation of protease inhibitors (alpha-1-antitrypsin) and the increase in the efficacy of virus protein proteolysis, in particular hemagglutinin and hence the acceleration of the infection activation of viral particles. The proteolytic provision of infection viral particle activation occurs due to cell membrane lipid peroxidation, by impairing their barrier function, this is an important condition for the generalization of infection and development of endemic processes. With this, involvement of St. aureus that secretes serine proteases accelerates the closing of the vicious circle of pathogenetic processes and further generalization of infection. The scheme of pathogenesis is based on the data on the molecular mechanisms of formation of free oxygen radicals, as well as on the structure of cell inhibitors of virus proteins.
authors.forename: O I
authors.initials: OI
authors.lastname: Kiselev
authors.forename: V A
authors.initials: VA
authors.lastname: Isakov
authors.forename: B P
authors.initials: BP
authors.lastname: Sharonov
authors.forename: V P
authors.initials: VP
authors.lastname: Sukhinin
mesh_terms: D005609:Free Radicals; D006388:Hemagglutinins / Q000378:metabolism*; D006801:Humans; D007251:Influenza, Human / Q000209:etiology* / Q000378:metabolism; D015227:Lipid Peroxidation; D010447:Peptide Hydrolases / Q000378:metabolism*; D012720:Severity of Illness Index; D000515:alpha 1-Antitrypsin / Q000378:metabolism*
chemical_list: D005609:Free Radicals; D006388:Hemagglutinins; D000515:alpha 1-Antitrypsin; D010447:Peptide Hydrolases