title: Thymus involvement in murine acquired immunodeficiency (MAIDS).
abstract: Due to self-renewal of the peripheral pool of T-cells, adult thymectomy has normally little influence on immunocompetence. However, thymus might play a more important role in the setting of viral-induced cytopathic effects on T-cells in the periphery. Therefore, thymus weight, cell numbers, and subset distribution were sequentially analysed after infection with RadLV-Rs, a viral mixture known to induce murine retrovirus induced immunodeficiency (MAIDS). Infection induced thymic atrophy (concerning organ weight as well as total cell number) which culminated seven weeks after inoculation. The atrophic process mostly reflected the depletion of double positive CD4+ CD8+ cells since their proportion sharply decreased around week 6. Single positive T-cells were less affected by the process. The proportion of B-cells progressively increased. Surprisingly, there was a strong correlation between the extent of atrophy and the frequency of B-cells in the thymus. Finally, an abnormal CD4+ T-cell subset lacking Thy-1 and previously described in the periphery also appeared in the thymus and its frequency was strongly correlated with the expansion of B-cells in this organ.
authors.affiliation: Laboratory of Pathology, University of Liège, Belgium.
authors.forename: S
authors.initials: S
authors.lastname: Colombi
authors.forename: M
authors.initials: M
authors.lastname: Deprez
authors.forename: L
authors.initials: L
authors.lastname: De Leval
authors.forename: C
authors.initials: C
authors.lastname: Humblet
authors.forename: R
authors.initials: R
authors.lastname: Greimers
authors.forename: M P
authors.initials: MP
authors.lastname: Defresne
authors.forename: J
authors.initials: J
authors.lastname: Boniver
authors.forename: M
authors.initials: M
authors.lastname: Moutschen
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology; D002352:Carrier Proteins / Q000096:biosynthesis; D002454:Cell Differentiation / Q000276:immunology; D005434:Flow Cytometry; D018960:Hyaluronan Receptors; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D016183:Murine Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D016721:Radiation Leukemia Virus; D011956:Receptors, Cell Surface / Q000096:biosynthesis; D016201:Receptors, Lymphocyte Homing / Q000096:biosynthesis; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000821:virology; D018800:Thy-1 Antigens / Q000276:immunology; D013950:Thymus Gland / Q000473:pathology* / Q000821:virology
chemical_list: D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D011956:Receptors, Cell Surface; D016201:Receptors, Lymphocyte Homing; D018800:Thy-1 Antigens