title: alpha-1-Antitrypsin (Pi) polymorphism in Serbia: deviation of Pi M subtype distribution from the Hardy-Weinberg equilibrium.
abstract: The distribution of the alpha 1-antitrypsin (Pi) phenotypes and subtypes was investigated in a population sample of 1060 unrelated individuals from Serbia (Yugoslavia). The allele frequencies estimates were: Pi*M1: 0.702; Pi*M2: 0.183; Pi*M3: 0.088; Pi*Z: 0.013, Pi*S: 0.007; Pi*P: 0.004; Pi*F: 0.003. The observed phenotype frequencies differed very significantly from those expected assuming H.W. equilibrium (chi 2 = 49.51, p < 0.0005). The deviation from equilibrium involved the three Pi*M subtypes: an excess of Pi*M1, Pi*M2 and Pi*M3 homozygotes was found, with the corresponding decreased number of M1M2 and M1M3 heterozygotes. The possible significance of this finding is discussed.
authors.affiliation: University Clinical Centre, Pharmaceutical Faculty, Belgrade, Yugoslavia.
authors.forename: Z
authors.initials: Z
authors.lastname: Jelić-Ivanović
authors.forename: V
authors.initials: V
authors.lastname: Spasojević-Kalimanovska
authors.forename: A
authors.initials: A
authors.lastname: Topić
authors.forename: S
authors.initials: S
authors.lastname: Spasić
authors.forename: V
authors.initials: V
authors.lastname: Petrović
mesh_terms: D000483:Alleles; D005787:Gene Frequency; D006801:Humans; D007525:Isoelectric Focusing; D008433:Mathematics; D010641:Phenotype; D011110:Polymorphism, Genetic; D015022:Yugoslavia; D000515:alpha 1-Antitrypsin / Q000235:genetics*
chemical_list: D000515:alpha 1-Antitrypsin