The phosphoinositide 3-kinase inhibitor wortmannin inhibits CD28-mediated T cell co-stimulation.
Wilson
A
A
School of Pharmacy and Pharmacology, University of Bath.
Sansom
D
D
Parry
R
R
Westwick
J
J
Ward
S
S
D000730:Androstadienes / Q000494:pharmacology*; D000818:Animals; D018106:CD28 Antigens / Q000276:immunology*; D016466:CHO Cells; D002460:Cell Line; D006224:Cricetinae; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006801:Humans; D008213:Lymphocyte Activation; D010710:Phosphates / Q000378:metabolism; D019869:Phosphatidylinositol 3-Kinases; D010768:Phosphoserine / Q000032:analysis; D010769:Phosphothreonine / Q000032:analysis; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors*; D019000:Phosphotyrosine; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology*; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000031:analogs & derivatives / Q000032:analysis / Q000378:metabolism; D000077191:Wortmannin
D000730:Androstadienes; D018106:CD28 Antigens; D004791:Enzyme Inhibitors; D010710:Phosphates; D010769:Phosphothreonine; D010768:Phosphoserine; D019000:Phosphotyrosine; D014443:Tyrosine; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D000077191:Wortmannin