title: [Significance of tumor angiogenesis as an independent prognostic factor in axillary node-negative breast cancer].
abstract: The value of tumor angiogenesis, EGFR and c-erbB-2 oncoprotein, a long with p 53 protein expression for predicting relapse-free survival was investigated in 110 node-negative breast cancer patients. The grade of neovascularization was assessed by the microvessel density which was obtained by an immunocytochemical staining by factor VIII-related antigen. EGFR, c-erbB-2 oncoprotein and p 53 oncoprotein were also determined by immunocytochemical assay. Univariate analysis showed no statistical significance of EGFR, c-erbB-2 and p53 status as a prognostic indicator. However, the microvessel density was a significant predictor of relapse-free survival. Patients with over 100 counts of factor VIII-RA positive cells per mm2 field in the most active areas of neovascularization showed significantly poorer prognosis compared to those with less than 100 counts (p < 0.005). Multivariate analysis demonstrated that microvessel density was an independent prognostic indicator in node-negative breast cancer patients (p < 0.0005). It was suggested that microvessel density might be of use in selecting the high-risk group in node-negative breast cancer patients needing adjuvant therapies.
authors.affiliation: Dept. of Surgery, Tokyo Metropolitan Komagome Hospital.
authors.forename: K
authors.initials: K
authors.lastname: Inada
authors.forename: M
authors.initials: M
authors.lastname: Toi
authors.forename: S
authors.initials: S
authors.lastname: Hoshina
authors.forename: K
authors.initials: K
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Tominaga
mesh_terms: D000230:Adenocarcinoma / Q000098:blood supply / Q000235:genetics / Q000556:secondary; D002293:Adenocarcinoma, Scirrhous / Q000098:blood supply / Q000235:genetics / Q000556:secondary; D001365:Axilla; D001859:Bone Neoplasms / Q000556:secondary; D001943:Breast Neoplasms / Q000098:blood supply* / Q000235:genetics / Q000473:pathology; D002291:Carcinoma, Papillary / Q000098:blood supply / Q000235:genetics / Q000556:secondary; D004815:Epidermal Growth Factor / Q000032:analysis; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000556:secondary; D008198:Lymph Nodes / Q000473:pathology*; D009389:Neovascularization, Pathologic / Q000175:diagnosis*; D011379:Prognosis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis; D012044:Regression Analysis; D016159:Tumor Suppressor Protein p53 / Q000032:analysis
chemical_list: D004815:Epidermal Growth Factor; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53