[Inhibitory effect of histamine-added mouse gamma-globulin on eosinophil accumulation induced by allergen in BALB/c mice].
Histamine-added human gamma-globulin (HG) has been clinically used as an anti-allergic drug for asthma, allergic rhinitis and atopic dermatitis. Retrospective analysis of clinical data have indicated that s.c. administration with HG not only improves clinical symptoms but also suppresses the number of eosinophils of nasal secretion or peripheral blood in allergic patients. Thus, the possibility was explored that HG may actively suppress eosinophil accumulation in allergic inflammation. The eosinophil accumulation in peritoneal cavity was induced by i.p. injection with ragweed pollen extract in BALB/c mice which had been repeatedly sensitized with the allergen for three weeks. Histamine-added mouse gamma-globulin (Mouse HG) at 150 mg/kg/day markedly inhibited the allergen-induced eosinophil accumulation when administered s.c. two times a week for three weeks. The inhibitory effect was almost the same as that of cyclosporin A at 100 mg/kg/day. Interestingly, equivalent dose of histamine or mouse gamma-globulin alone had no inhibitory effect in the same system. These results suggest that HG suppresses chronic allergic inflammation through the inhibition of eosinophil accumulation.
Yoshii
H
H
Department of Haematology and Immunology, Nippon Zoki Pharmaceutical Company.
Fukata
Y
Y
Yamamoto
K
K
Yago
H
H
Suehiro
S
S
Yanagihara
Y
Y
Okudaira
H
H
D000485:Allergens / Q000276:immunology*; D000818:Animals; D002908:Chronic Disease; D016572:Cyclosporine / Q000494:pharmacology / Q000627:therapeutic use; D004338:Drug Combinations; D004804:Eosinophils / Q000276:immunology*; D005260:Female; D006632:Histamine / Q000494:pharmacology* / Q000627:therapeutic use; D006967:Hypersensitivity / Q000276:immunology* / Q000628:therapy; D051379:Mice; D008807:Mice, Inbred BALB C; D010529:Peritoneal Cavity / Q000166:cytology; D005719:gamma-Globulins / Q000494:pharmacology* / Q000627:therapeutic use
D000485:Allergens; D004338:Drug Combinations; D005719:gamma-Globulins; D006632:Histamine; D016572:Cyclosporine