Suppression of experimental antigen-induced arthritis in transgenic mice producing human alpha-fetoprotein.
Experimental arthritis was induced in the knee joint of transgenic mice expressing human alpha-fetoprotein by immunization with methylated bovine serum albumin in Freund's complete adjuvant. In the control experiment with normal C57BL/6 mice, definite arthritis was observed in 55.6% (5/9) of the mice, but in only 21.1% (4/19) of the transgenic mice. This result suggested that human alpha-fetoprotein functioned as an immunosuppressant to ameliorate the development of the immune disease.
Ogata
A
A
Department of Biochemistry, Hokkaido University School of Medicine, Sapporo, Japan.
Yamashita
T
T
Koyama
Y
Y
Sakai
M
M
Nishi
S
S
D000818:Animals; D001169:Arthritis, Experimental / Q000276:immunology / Q000473:pathology / Q000517:prevention & control*; D005620:Freund's Adjuvant; D006801:Humans; D006984:Hypertrophy; D007166:Immunosuppressive Agents; D007249:Inflammation; D007596:Joints / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008822:Mice, Transgenic; D012710:Serum Albumin, Bovine / Q000276:immunology; D013583:Synovial Membrane / Q000473:pathology; D000509:alpha-Fetoproteins / Q000096:biosynthesis*
D007166:Immunosuppressive Agents; D000509:alpha-Fetoproteins; C029180:methylated bovine serum albumin; D012710:Serum Albumin, Bovine; D005620:Freund's Adjuvant