Changes in serum granulocyte colony-stimulating factor (G-CSF) and interleukin 6 (IL-6) after surgical intervention.
To evaluate the physiological role of G-CSF following surgery, we measured the serum levels of immunoreactive IL-6 and G-CSF sequentially in nine patients after major elective thoracoabdominal surgery for esophageal carcinoma. Both G-CSF and IL-6 levels reached their maxima at the first postoperative day and decreased thereafter. There was a significant correlation between serum G-CSF (y) and IL-6 (x) levels (y = 3.273x + 3.991; r = 0.787, n = 78, p < 0.001). In the case that developed aspiration pneumonia and ARDS at the second postoperative day, the measured G-CSF level was less than half the predicted value. The relationship between serum G-CSF and IL-6 levels supports the central role of G-CSF as the host defense response modifier and, thus, low G-CSF levels in the circulation is one reason for the immunodeficient state after major surgery.
Toda
H
H
Department of Surgery II, Osaka University Medical School, Japan.
Murata
A
A
Tanaka
N
N
Ohashi
I
I
Kato
T
T
Hayashida
H
H
Matsuura
N
N
Monden
M
M
D000368:Aged; D004797:Enzyme-Linked Immunosorbent Assay; D004938:Esophageal Neoplasms / Q000150:complications / Q000601:surgery*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood* / Q000276:immunology; D006801:Humans; D015850:Interleukin-6 / Q000097:blood* / Q000276:immunology; D007813:Laparotomy / Q000009:adverse effects; D008197:Lymph Node Excision / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000097:blood* / Q000276:immunology; D013908:Thoracotomy / Q000009:adverse effects
D015850:Interleukin-6; D016179:Granulocyte Colony-Stimulating Factor