title: Effect of RANTES on intracellular expression of EG2 antigen in eosinophils.
abstract: RANTES, which is released from thrombin-stimulated platelets, is a member of the 8-kDa cytokine family that has been shown to possess chemotactic activity for eosinophils. The effect of RANTES on the intracellular expression of EG2 antigen in eosinophils was examined in this study. RANTES augmented the intracellular expression of EG2 antigen in eosinophils. These findings suggest that RANTES not only modulates the chemotactic activity of eosinophils but also intensifies the function of eosinophil activation.
authors.affiliation: Fourth Department of Internal Medicine, Kinki University, Osaka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kakazu
authors.forename: J
authors.initials: J
authors.lastname: Chihara
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: I
authors.initials: I
authors.lastname: Higashimoto
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: D
authors.initials: D
authors.lastname: Kurachi
authors.forename: S
authors.initials: S
authors.lastname: Nakajima
mesh_terms: D001249:Asthma / Q000473:pathology; D001798:Blood Proteins / Q000378:metabolism*; D018946:Chemokine CCL5 / Q000494:pharmacology*; D002630:Chemotactic Factors / Q000494:pharmacology*; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D012260:Ribonucleases
chemical_list: D001798:Blood Proteins; D018946:Chemokine CCL5; D002630:Chemotactic Factors; D047091:Eosinophil Granule Proteins; D012260:Ribonucleases