title: Pharmaceutical characterization of commercially available intravenous fat emulsions: estimation of average particle size, size distribution and surface potential using photon correlation spectroscopy.
abstract: Particle profiles such as the average diameter, size distribution and dispersion, as well as the zeta potential, of commercially available intravenous fat emulsions of high-calorie nutrient fluids (6 products) and drug carriers (4 products) were examined using photon correlation spectroscopy (dynamic light scattering). Wide variations were observed in number-weighted (dn), weight-weighted (dw) and z-average diameters, and dw/dn ratios as a measure of polydispersity. Average size is not sufficient for the pharmaceutical characterization of particles and the determination of size distribution or dw/dn value is essential for more precise information. Although measuring the zeta potential of fat emulsions is of considerable value in estimating their stability on long-term storage, a medium which accurately reflects the environment of the droplets in the system of interest should be chosen when diluting the emulsion.
authors.affiliation: Division of Drugs, Osaka Branch, National Institute of Health Sciences, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Komatsu
authors.forename: A
authors.initials: A
authors.lastname: Kitajima
authors.forename: S
authors.initials: S
authors.lastname: Okada
mesh_terms: D015502:Absorptiometry, Photon; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004586:Electrophoresis; D005217:Fat Emulsions, Intravenous; D006863:Hydrogen-Ion Concentration; D010316:Particle Size; D013499:Surface Properties
chemical_list: D005217:Fat Emulsions, Intravenous