title: The chronic presence of the parasite, and anti-P autoimmunity in Chagas disease: the Trypanosoma cruzi ribosomal P proteins, and their recognition by the host immune system.
abstract: Molecular expression cloning techniques revealed that patients with the severest clinical form of Chagas disease, chronic Chagas heart disease, presented a strong humoral response against the cloned C-terminal portion of a Trypanosoma cruzi ribosomal P protein. Parasite P antigens identification led to characterize the ribosomal P protein system in T. cruzi. Their exposed location on the ribosome, and the "amplification" of their parasite specific, serine free C-terminal domain, generate a strong parasite specific anti-P response, that in certain cases may induce anti-P autoimmunity.
authors.affiliation: Instituto de Investigaciones en Ingeniería Genética y Biología Molecular (INGEBI), Buenos Aires, Argentina.
authors.forename: D
authors.initials: D
authors.lastname: Kaplan
authors.forename: M
authors.initials: M
authors.lastname: Vazquez
authors.forename: S
authors.initials: S
authors.lastname: Lafon
authors.forename: A G
authors.initials: AG
authors.lastname: Schijman
authors.forename: G
authors.initials: G
authors.lastname: Levitus
authors.forename: M J
authors.initials: MJ
authors.lastname: Levin
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000953:Antigens, Protozoan / Q000276:immunology*; D015551:Autoimmunity; D014355:Chagas Disease / Q000276:immunology*; D002908:Chronic Disease; D000939:Epitopes / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D015800:Protozoan Proteins / Q000276:immunology*; D012269:Ribosomal Proteins / Q000276:immunology*; D014349:Trypanosoma cruzi / Q000276:immunology*
chemical_list: D000953:Antigens, Protozoan; D000939:Epitopes; C064601:L12E protein, Trypanosoma cruzi; D015800:Protozoan Proteins; D012269:Ribosomal Proteins