title: Three isoforms of platelet-derived growth factors all have the capability to induce angiogenesis in vivo.
abstract: Three isoforms of platelet-derived growth factors (PDGFs) composing of AA, AB, and BB chains all exhibited angiogenic activity in a dose-dependent manner in an in vivo assay system involving the chorioallantoic membrane of chick embryo. The order of potency as BB > AB = AA. They, however, failed to stimulate proliferation of vascular endothelial cells, suggesting that their effects are indirect. These data suggest that possibility that three PDGF isoforms are indirect angiogenic factors.
authors.affiliation: Department of Cancer Therapeutics, Tokyo Metropolitan Institute of Medical Science, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Oikawa
authors.forename: C
authors.initials: C
authors.lastname: Onozawa
authors.forename: M
authors.initials: M
authors.lastname: Sakaguchi
authors.forename: I
authors.initials: I
authors.lastname: Morita
authors.forename: S
authors.initials: S
authors.lastname: Murota
mesh_terms: D000818:Animals; D002455:Cell Division / Q000187:drug effects; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply / Q000187:drug effects; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects; D007536:Isomerism; D009389:Neovascularization, Pathologic / Q000139:chemically induced* / Q000503:physiopathology; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology*; D012039:Regional Blood Flow / Q000187:drug effects
chemical_list: D010982:Platelet-Derived Growth Factor