title: Abnormalities of B cells and dendritic cells in SAMP1 mice.
abstract: The age-related changes in the function of antigen-presenting cells (APC) were examined using a substrain of senescence-accelerated mouse (SAMP1). In the primary mixed lymphocyte reaction (MLR), dendritic cells (DC) from aged SAMP1 mice showed less stimulatory activity than those of age-matched BALB/c or young SAMP1 mice. In the secondary MLR, the stimulatory activity of B cells was found to be lower in aged SAMP1 mice but not in age-matched BALB/c or young SAMP1 mice. In addition, these age-related decreases in the stimulatory activity of APC were found to be related to changes in the surface density of major histocompatibility complex class II and intercellular adhesion molecule-1 (ICAM-1) (but not B7-1 or B7-2 molecule) on APC (DC and B cells).
authors.affiliation: First Department of Pathology, Kansai Medical University, Osaka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Haruna
authors.forename: M
authors.initials: M
authors.lastname: Inaba
authors.forename: K
authors.initials: K
authors.lastname: Inaba
authors.forename: S
authors.initials: S
authors.lastname: Taketani
authors.forename: K
authors.initials: K
authors.lastname: Sugiura
authors.forename: Y
authors.initials: Y
authors.lastname: Fukuba
authors.forename: H
authors.initials: H
authors.lastname: Doi
authors.forename: J
authors.initials: J
authors.lastname: Toki
authors.forename: R
authors.initials: R
authors.lastname: Tokunaga
authors.forename: S
authors.initials: S
authors.lastname: Ikehara
mesh_terms: D000375:Aging / Q000276:immunology*; D000818:Animals; D000917:Antibody Formation; D017951:Antigen Presentation / Q000235:genetics; D016175:B-Lymphocyte Subsets / Q000276:immunology / Q000473:pathology*; D018122:B7-1 Antigen / Q000276:immunology; D016026:Bone Marrow Transplantation; D003713:Dendritic Cells / Q000276:immunology / Q000473:pathology*; D004195:Disease Models, Animal; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D016219:Immunotherapy, Adoptive; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology*; D007959:Lymphocyte Culture Test, Mixed; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains / Q000276:immunology*; D011371:Progeria / Q000235:genetics / Q000276:immunology* / Q000473:pathology / Q000628:therapy; D011828:Radiation Chimera; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology / Q000637:transplantation
chemical_list: D018122:B7-1 Antigen; D000949:Histocompatibility Antigens Class II; D018799:Intercellular Adhesion Molecule-1