Structural organization and mapping of the human TCF11 gene.
We recently cloned human cDNA representing several mRNA isoforms of human TCF11, a transcription factor of the basic-region, leucine-zipper (bZIP) family located on chromosome 17q22 as well as a genomic clone of this gene. We have now determined the complete genomic organization of the TCF11 gene, which consists of 9 exons distributed over 15 kb of genomic DNA. Pulsed-field gel electrophoresis was used to construct a physical map around TCF11, to characterize a 450-kb YAC clone that contains the gene, and to link TCF11 physically to BTR, a marker on chromosome 17.
Luna
L
L
Biotechnology Centre of Oslo, University of Oslo, Blindern, Norway.
Skammelsrud
N
N
Johnsen
O
O
Abel
K J
KJ
Weber
B L
BL
Prydz
H
H
Kolstø
A B
AB
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015139:Blotting, Southern; D002107:Caenorhabditis / Q000235:genetics; D029742:Caenorhabditis elegans Proteins; D002874:Chromosome Mapping; D015342:DNA Probes; D018076:DNA, Complementary / Q000737:chemistry; D004268:DNA-Binding Proteins; D005091:Exons; D015801:Helminth Proteins / Q000235:genetics; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D051265:NF-E2-Related Factor 1; D017385:Sequence Homology; D014157:Transcription Factors / Q000235:genetics*
D029742:Caenorhabditis elegans Proteins; D015342:DNA Probes; D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D015801:Helminth Proteins; D051265:NF-E2-Related Factor 1; C088357:NFE2L1 protein, human; D014157:Transcription Factors; C073702:skn-1 protein, C elegans