Effects of metamfetamine on auditory P3 component of event-related potentials in rats.
Three rats were trained with an oddball paradigm, in which 5 kHz frequent and 10 kHz target rare tones were presented with a probability of 0.8 and 0.2. Pressing the lever within 2 s following the onset of the target tones was rewarded with a drop of food paste. Long latency event-related potentials (ERPs) corresponding to those in humans could be recorded in rats. After the administration of metamfetamine (0.2 mg/kg), the amplitude of surface and intracortical N1 increased, indicating an augmentation of the primary cortical response. Surface P3 showed a decrease of amplitude, accompanied by an increase of intracortical negativity. These alterations of ERPs may be caused by the dysregulation of central noradrenergic system.
Iwanami
A
A
Department of Psychiatry, Showa University School of Medicine, Tokyo, Japan.
Shinba
T
T
Sumi
M
M
Ozawa
N
N
Yamamoto
K
K
D000662:Amphetamines / Q000494:pharmacology*; D000818:Animals; D001288:Attention; D004569:Electroencephalography / Q000187:drug effects; D005072:Evoked Potentials, Auditory / Q000187:drug effects*; D007273:Injections, Intramuscular; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344; D000159:Vestibulocochlear Nerve / Q000187:drug effects*
D000662:Amphetamines