title: Neutrophil and monocyte beta 2-integrin expression in trisomic fetuses.
abstract: Flow cytometry was used to measure neutrophil and monocyte beta 2-integrin expression in fetuses with trisomy 18 (n = 7) and trisomy 21 (n = 7) at 20-25 weeks' gestation. The values were compared with those of 112 chromosomally normal fetuses. There were no significant differences in beta 2-integrin expression between normal and aneuploid fetuses. These findings demonstrate that in trisomies 21 and 18, alteration in beta 2-integrin expression is unlikely to contribute to the pathogenesis of immunological deficiencies that have been observed in these aneuploidies both prenatally and postnatally.
authors.affiliation: Harris Birthright Research Centre for Fetal Medicine, King's College Hospital School of Medicine, London, U.K.
authors.forename: G
authors.initials: G
authors.lastname: Makrydimas
authors.forename: B
authors.initials: B
authors.lastname: Thilaganathan
authors.forename: N
authors.initials: N
authors.lastname: Plachouras
authors.forename: K H
authors.initials: KH
authors.lastname: Nicolaides
mesh_terms: D000782:Aneuploidy; D018821:CD18 Antigens; D004314:Down Syndrome / Q000276:immunology; D005260:Female; D005333:Fetus / Q000276:immunology*; D005434:Flow Cytometry; D006801:Humans; D016023:Integrins / Q000096:biosynthesis*; D009000:Monocytes / Q000276:immunology*; D009504:Neutrophils / Q000276:immunology*; D011247:Pregnancy; D014314:Trisomy / Q000276:immunology*
chemical_list: D018821:CD18 Antigens; D016023:Integrins