Histopathologic investigations of acute and subchronic toxicities of some organotin compounds in chickens.
The acute and subchronic oral toxicities of 4 organotin derivatives were investigated in chickens. The LD50 values oscillated between 200 and 400 mg/kg bw and revealed a moderate or weak toxicity. Subchronic dosing with 2 doses from each compound at 2 and 10 mg/kg bw induced dose-dependent lesions seen at necropsy and histologic examinations. Involution of the thymus and bursa Fabricius, fatty degeneration of the liver, and nephrotic syndromes were the most evident effects. The butyltin derivatives induced more drastic lesions than did the phenyltins.
Socaciu
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Department of Biochemistry, University of Agricultural Sciences, Cluj-Napoca, Romania.
Baba
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Rotaru
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D000818:Animals; D002060:Bursa of Fabricius / Q000187:drug effects* / Q000473:pathology; D002645:Chickens; D004305:Dose-Response Relationship, Drug; D005234:Fatty Liver / Q000139:chemically induced*; D005269:Femur / Q000187:drug effects / Q000473:pathology; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D007928:Lethal Dose 50; D009947:Organotin Compounds / Q000633:toxicity*; D016612:Paraffin Embedding; D013194:Staining and Labeling; D013329:Structure-Activity Relationship; D013950:Thymus Gland / Q000187:drug effects* / Q000293:injuries / Q000473:pathology; D013961:Thyroid Gland / Q000187:drug effects / Q000473:pathology
D009947:Organotin Compounds; C056189:di-n-butyltin; C020735:dibutyldichlorotin