Cyclic AMP elevating agents synergize with inflammatory cytokines to induce an inducible type of nitric oxide synthase in cultured vascular smooth muscle cells.
Nakayama
I
I
Department of Internal Medicine (1st Division) Kobe University School of Medicine, Japan.
Kawahara
Y
Y
Tsuda
T
T
Koide
M
M
Yokoyama
M
M
D000527:Alprostadil / Q000008:administration & dosage; D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis* / Q000235:genetics; D000818:Animals; D003994:Bucladesine / Q000008:administration & dosage; D002478:Cells, Cultured; D005576:Colforsin / Q000008:administration & dosage; D000242:Cyclic AMP / Q000502:physiology*; D016207:Cytokines / Q000008:administration & dosage*; D004357:Drug Synergism; D004790:Enzyme Induction / Q000187:drug effects; D011464:Epoprostenol / Q000008:administration & dosage / Q000031:analogs & derivatives; D015870:Gene Expression / Q000187:drug effects; D066298:In Vitro Techniques; D007371:Interferon-gamma / Q000008:administration & dosage; D009131:Muscle, Smooth, Vascular / Q000201:enzymology*; D019001:Nitric Oxide Synthase; D012333:RNA, Messenger / Q000235:genetics; D051381:Rats
D016207:Cytokines; D012333:RNA, Messenger; D005576:Colforsin; C048081:beraprost; D003994:Bucladesine; D007371:Interferon-gamma; D011464:Epoprostenol; D000242:Cyclic AMP; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D000527:Alprostadil