title: Oxygen bubbling can improve the labelling of pentavalent technetium-99m dimercaptosuccinic acid.
abstract: It has previously been reported that almost all of the trivalent technetium-99m dimercaptosuccinic acid (99mTc (III) DMSA) present in the labelling product of pentavalent technetium-99m DMSA (99mTc (V) DMSA) can be changed into 99mTc (V) DMSA by bubbling with pure oxygen. We therefore performed studies in animals (mice) and humans to investigate the effect of such oxygen bubbling on the labelling efficiency of and on the renal uptake of 99mTc. The method of labelling of 99mTc (V) DMSA was that of Hirano. It was found that oxygen bubbling oxidized the contaminated 99mTc (III) DMSA into 99mTc (V) DMSA in vitro and decreased the uptake of radioactivity in the kidney in both animals and humans.
authors.affiliation: Department of Nuclear Medicine, Kyoto University, Faculty of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kobayashi
authors.forename: K H
authors.initials: KH
authors.lastname: Suzuki
authors.forename: H
authors.initials: H
authors.lastname: Sakahara
authors.forename: Z S
authors.initials: ZS
authors.lastname: Yao
authors.forename: A
authors.initials: A
authors.lastname: Yokoyama
authors.forename: J
authors.initials: J
authors.lastname: Konishi
mesh_terms: D000818:Animals; D006801:Humans; D007553:Isotope Labeling; D007668:Kidney / Q000000981:diagnostic imaging*; D051379:Mice; D008807:Mice, Inbred BALB C; D015609:Organotechnetium Compounds; D010100:Oxygen; D011877:Radionuclide Imaging; D011933:Reagent Kits, Diagnostic; D004113:Succimer; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014018:Tissue Distribution
chemical_list: D015609:Organotechnetium Compounds; D011933:Reagent Kits, Diagnostic; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer; D010100:Oxygen