Felty's syndrome treated with rhG-CSF associated with flare of arthritis and skin rash.
A patient with Felty's syndrome and rheumatoid arthritis was treated with recombinant granulocyte stimulating factor rhG-CSF (Neupogen) in view of severe neutropenia. He had a prompt rise in his neutrophil count and associated with this a severe flare of his arthritis and a skin rash. rhG-CSF was stopped, his neutrophil count fell rapidly and his symptoms resolved. rhG-CSF and the resulting rise in neutrophil count may be associated with flare of autoimmune disease in susceptible individuals.
McMullin
M F
MF
Queen's University of Belfast.
Finch
M B
MB
D001172:Arthritis, Rheumatoid / Q000150:complications* / Q000503:physiopathology; D003875:Drug Eruptions / Q000209:etiology*; D005258:Felty Syndrome / Q000150:complications* / Q000188:drug therapy* / Q000503:physiopathology; D000069585:Filgrastim; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000188:drug therapy* / Q000209:etiology; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D000069585:Filgrastim