Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice.
Airway hyperresponsiveness is a key characteristic of human asthma and a marker for asthma-like conditions in animals. F1 mice derived from A/J and C57BL/6J display a phenotype which resembles the asthma-like phenotype of the A/J mice. Since airway responsiveness failed to segregate as a mendelian trait, we show significant linkage at two loci, Bhr1 (lod = 3.0) and Bhr2 (lod = 3.7) on chromosomes 2 and 15. A third locus, Bhr3 (lod = 2.83), maps to chromosome 17. Each of these loci maps near candidate loci implicated in the pathobiology of asthma. Our study represents the first linkages established through a genome-wide survey of airway hyperresponsiveness in any mammal.
De Sanctis
G T
GT
Combined Program in Pulmonary and Critical Care Medicine, Brigham Women's Hospital, Boston, Massachusetts 02115, USA.
Merchant
M
M
Beier
D R
DR
Dredge
R D
RD
Grobholz
J K
JK
Martin
T R
TR
Lander
E S
ES
Drazen
J M
JM
D000704:Analysis of Variance; D000818:Animals; D001249:Asthma / Q000235:genetics* / Q000503:physiopathology*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA / Q000032:analysis / Q000302:isolation & purification; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008126:Lod Score; D008168:Lung / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008322:Mammals; D016210:Methacholine Chloride / Q000494:pharmacology; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D010277:Parasympathomimetics / Q000494:pharmacology; D010641:Phenotype; D010991:Plethysmography; D016133:Polymerase Chain Reaction; D012129:Respiratory Function Tests
D010277:Parasympathomimetics; D016210:Methacholine Chloride; D004247:DNA