title: [Study of reverse transcriptase selectivity. Substrate properties of new 2',3'-unsaturated acyclic nucleotide analogs].
abstract: A new series of nucleotide analogs, (Z)-pyrophosphoryl (phosphonyloxymethyl) but-2-enyl derivatives of pyrimidines and purines, was synthesized. Their substrate and inhibitory properties toward some DNA polymerases and reverse transcriptases were evaluated. They were shown to be selective inhibitors of HIV reverse transcriptase. The structure-substrate properties relationships for nucleotide analogs were discussed.
authors.forename: E A
authors.initials: EA
authors.lastname: Shirokova
authors.forename: A V
authors.initials: AV
authors.lastname: Shipitsyn
authors.forename: D G
authors.initials: DG
authors.lastname: Semizarov
mesh_terms: D001483:Base Sequence; D004259:DNA-Directed DNA Polymerase / Q000378:metabolism; D006678:HIV / Q000201:enzymology; D008969:Molecular Sequence Data; D019384:Nucleic Acid Synthesis Inhibitors; D009711:Nucleotides / Q000378:metabolism*; D012194:RNA-Directed DNA Polymerase / Q000378:metabolism*; D018894:Reverse Transcriptase Inhibitors; D013379:Substrate Specificity
chemical_list: D019384:Nucleic Acid Synthesis Inhibitors; D009711:Nucleotides; D018894:Reverse Transcriptase Inhibitors; D012194:RNA-Directed DNA Polymerase; D004259:DNA-Directed DNA Polymerase