[The metabolism of heavy metals depends on the vitamin-D status of the body].
The effect of vitamin D3 and its two metabolites 1,25(OH)2D3 and 24,25(OH)2D3 on the metabolism of heavy metals--Sr, Pb and Cd was studied. The experiments were carried out on chickens, the heavy metals were added to the chicken's ration. The results obtained demonstrated that vitamin D3 caused accumulation of those metals in tissues and their toxicity in organisms. When increasing the vitamin dose from 200 to 500 IU on 1 kg of ration that tendency was being heightened. On the three steroids which had been studied the metabolite 1,25(OH)2D3 displayed the greatest activity in accumulating metals in tissues, Pb in particular. The effect of 24,25(OH)2D3 on the indices being studied was comparable with that of vitamin D3.
Babarykin
D A
DA
Latvian Medical Academy, Riga.
Bauman
V K
VK
D015650:24,25-Dihydroxyvitamin D 3 / Q000008:administration & dosage / Q000378:metabolism; D000818:Animals; D002104:Cadmium / Q000032:analysis / Q000493:pharmacokinetics*; D002117:Calcitriol / Q000008:administration & dosage / Q000378:metabolism; D002645:Chickens; D002762:Cholecalciferol / Q000008:administration & dosage / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D007854:Lead / Q000032:analysis / Q000493:pharmacokinetics*; D013054:Spectrophotometry, Atomic; D013324:Strontium / Q000032:analysis / Q000493:pharmacokinetics*
D002104:Cadmium; D002762:Cholecalciferol; D007854:Lead; D015650:24,25-Dihydroxyvitamin D 3; D002117:Calcitriol; D013324:Strontium