title: The concept of "direct mechanical ventricular assistance" in the treatment of left-ventricular failure. Part 1: Idea, development and construction of an implantable multi-chamber pump system partially surrounding the heart.
abstract: In this paper we present a therapeutic concept for the treatment of heart failure due to muscular inability to pump properly. The basic principle of this concept triggered numerous studies, then with the aim of cardiopulmonary resuscitation, back in the 1970s. In general, it dealt with mechanical systems which led to an increase in stroke volume, systolic blood pressure, and cardiac output through the application of pressure directly to the left ventricle. After a critical appraisal of the relevant literature from technical, physical, and medical viewpoints, and our own preliminary studies on animal hearts within the framework of mock circulation experiments, we have conceived a new functional principle for direct mechanical ventricular assistance based on squeezing the left ventricle only. We have begun development of the system which has the advantages of ease of use, high biocompatibility due to lack of contact between blood and system components, the prevention of infection through complete intrathoracic implantation (long-range goal), and the fact that the patient's own heart can be supported by the system without being removed from the circulatory system (support of the residual myocardial function). Technical as well as medical prerequisites are indicated, and the materials selection and construction principles of the control, pressure generation, pressure transduction, and ventricular compression unit are described. It has proved possible to construct a prototype system to be used in animal experiments, which, through pneumatic inflation of a chamber system partially surrounding the left ventricle, should be able to augment or take over the pumping function of the left ventricle.
authors.affiliation: Department of Thoracic- and Cardiovascular Surgery, Homburg University Hospital, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Feindt
authors.forename: E
authors.initials: E
authors.lastname: Gams
authors.forename: A
authors.initials: A
authors.lastname: Kazi
authors.forename: U
authors.initials: U
authors.lastname: Straub
authors.forename: V
authors.initials: V
authors.lastname: Paul
authors.forename: J
authors.initials: J
authors.lastname: Priebe
authors.forename: U
authors.initials: U
authors.lastname: Meyer
authors.forename: K
authors.initials: K
authors.lastname: Gersonde
mesh_terms: D000818:Animals; D004867:Equipment Design; D006353:Heart-Assist Devices; D018487:Ventricular Dysfunction, Left / Q000628:therapy*