title: Castration increases [125I]MK801 binding in the hippocampus of male rats.
abstract: This study examines the effect of castration and androgen replacement on [125I]MK801 binding in the hippocampus. In castrated male rats, [125I]MK801 binding was significantly increased in both the stratum oriens and radiatum and the pyramidal cell layer of CA1. In contrast, no increase in [125I]MK801 binding was observed in the stratum oriens and radiatum of CA1 of castrated rats that were treated with dihydrotestosterone. No change in [125I]MK801 binding was observed in the CA3 region or dentate gyrus after castration. The observed increase in [125I]MK801 binding in pyramidal cell neurons within CA1 suggests that androgens may potentially affect hippocampal function by modulating pyramidal cell NMDA receptors.
authors.affiliation: Department of Veterinary PathoBiology, University of Minnesota, St. Paul 55108, USA.
authors.forename: L
authors.initials: L
authors.lastname: Kus
authors.forename: R J
authors.initials: RJ
authors.lastname: Handa
authors.forename: J M
authors.initials: JM
authors.lastname: Hautman
authors.forename: A J
authors.initials: AJ
authors.lastname: Beitz
mesh_terms: D000728:Androgens / Q000172:deficiency / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D016291:Dizocilpine Maleate / Q000378:metabolism* / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008297:Male; D009919:Orchiectomy; D051381:Rats; D011916:Rats, Inbred F344; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
chemical_list: D000728:Androgens; D007457:Iodine Radioisotopes; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate