Tetrahydro-9-aminoacridine presynaptically inhibits glutamatergic transmission in the rat amygdala.
The effect of the centrally active anticholinesterase inhibitor tetrahydro-9-aminoacridine (THA) on synaptic transmission was studied in rat amygdala neurons in the in vitro slice preparation. THA reversibly suppressed the excitatory postsynaptic potential (EPSP) in a concentration-dependent manner. Postsynaptic depolarization induced by alpha-amino-5-methyl-4-isoxazole propionate (AMPA) was not decreased by THA. These results demonstrate that THA has a presynaptic inhibitory action on the physiology of synaptic transmission in the amygdala. Pretreating the slices with atropine did not affect THA's effect, indicating that the presynaptic muscarinic receptors are not involved.
Wang
S J
SJ
Department of Pharmacology, College of Medicine, National Cheng-Kung University, Tainan City, Taiwan, Republic of China.
Huang
C C
CC
Gean
P W
PW
D000679:Amygdala / Q000187:drug effects*; D000818:Animals; D001285:Atropine / Q000494:pharmacology; D004558:Electric Stimulation; D005071:Evoked Potentials / Q000187:drug effects; D018698:Glutamic Acid / Q000502:physiology*; D066298:In Vitro Techniques; D008297:Male; D008839:Microelectrodes; D051381:Rats; D017207:Rats, Sprague-Dawley; D017661:Receptors, Presynaptic / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*; D013619:Tacrine / Q000494:pharmacology*; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid / Q000494:pharmacology
D017661:Receptors, Presynaptic; D018698:Glutamic Acid; D013619:Tacrine; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D001285:Atropine