title: PROANAL version 2: multifunctional program for analysis of multiple protein sequence alignments and for studying the structure--activity relationships in protein families.
abstract: A new version of the program PROANAL is described. A multiple linear regression analysis of the protein structure--activity relationship allows one to investigate the combinations of protein sites and factors influencing the activity. The program also provides the possibility to seek out protein sites, conservative or variable in variations of physicochemical characteristics, and regions with high or low values of these characteristics. PROANAL2 may be useful in the simulation of protein-engineering experiments and in the search of a number of protein regions such as functional sites, secondary structures, solvent-exposed regions, T- and B-cell antigenic determinants, etc.
authors.affiliation: Research Institute of Molecular Biology, NPO Vector, Koltsovo, Novosibirsk Region, Russia.
authors.forename: A M
authors.initials: AM
authors.lastname: Eroshkin
authors.forename: V I
authors.initials: VI
authors.lastname: Fomin
authors.forename: P A
authors.initials: PA
authors.lastname: Zhilkin
authors.forename: V V
authors.initials: VV
authors.lastname: Ivanisenko
authors.forename: Y V
authors.initials: YV
authors.lastname: Kondrakhin
mesh_terms: D000465:Algorithms; D000595:Amino Acid Sequence; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D017124:Conserved Sequence; D019483:Disintegrins; D005069:Evaluation Studies as Topic; D007372:Interferons / Q000737:chemistry / Q000235:genetics; D010455:Peptides / Q000737:chemistry / Q000235:genetics; D011506:Proteins / Q000737:chemistry / Q000235:genetics*; D012044:Regression Analysis; D016415:Sequence Alignment / Q000379:methods* / Q000706:statistics & numerical data; D012984:Software; D013329:Structure-Activity Relationship
chemical_list: D019483:Disintegrins; D010455:Peptides; D011506:Proteins; D007372:Interferons