title: Dysgerminoma of the ovary in a patient with triple-X syndrome.
abstract: A 24-year-old patient with dysgerminoma of the right ovary and hypoplastic left ovary was screened for chromosomal aberration. Triple-X syndrome was found in the oral epithelium and lymphocyte culture, while chromosomal in situ hybridization of the tumor itself showed a normal XX karyotype. Although trisomy X and dysgerminoma are coincidental findings in our case report, women with malignant germ cell tumors and abnormal genitalia should be checked for chromosomal aberrations to exclude anomalies carrying a Y chromosome.
authors.affiliation: Department of Obstetrics and Gynaecology, Technical University Hospital of Aachen, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Kemp
authors.forename: S
authors.initials: S
authors.lastname: Hauptmann
authors.forename: W
authors.initials: W
authors.lastname: Schröder
authors.forename: B
authors.initials: B
authors.lastname: Amo-Takyi
authors.forename: B
authors.initials: B
authors.lastname: Leeners
authors.forename: W
authors.initials: W
authors.lastname: Rath
mesh_terms: D000328:Adult; D004407:Dysgerminoma / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology; D014314:Trisomy; D014960:X Chromosome