Inhibition of heparan sulphate and other glycosaminoglycans binding to Helicobacter pylori by various polysulphated carbohydrates.
Heparan sulphate binding to Helicobacter pylori at pH 4 to 5 was inhibited with various sulphated polysaccharides (heparin and chondroitin sulphates, fucoidan, carrageenans and some others), but not by carboxylated or nonsulphated compounds. Heparin binding proteins are exposed on the cell surface.
Hirmo
S
S
University of Lund, Institute of Medical Microbiology, Sweden.
Utt
M
M
Ringner
M
M
Wadström
T
T
D000818:Animals; D001422:Bacterial Adhesion / Q000187:drug effects*; D001425:Bacterial Outer Membrane Proteins / Q000737:chemistry; D001667:Binding, Competitive; D002351:Carrageenan / Q000494:pharmacology; D002417:Cattle; D002809:Chondroitin Sulfates / Q000494:pharmacology; D016264:Dextran Sulfate / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D016480:Helicobacter pylori / Q000502:physiology*; D006493:Heparin / Q000494:pharmacology; D006497:Heparan Sulfate / Q000378:metabolism*; D010426:Pentosan Sulfuric Polyester / Q000494:pharmacology; D011134:Polysaccharides / Q000494:pharmacology*; D013463:Sulfuric Acid Esters / Q000494:pharmacology*; D014990:Xylans / Q000494:pharmacology
D001425:Bacterial Outer Membrane Proteins; D002351:Carrageenan; D002809:Chondroitin Sulfates; D016264:Dextran Sulfate; D006493:Heparin; D006497:Heparan Sulfate; D010426:Pentosan Sulfuric Polyester; D011134:Polysaccharides; D013463:Sulfuric Acid Esters; D014990:Xylans; C007789:fucoidan