title: Disruption of retinal axon ingrowth by ablation of embryonic mouse optic chiasm neurons.
abstract: Mouse retinal ganglion cell axons growing from the eye encounter embryonic neurons at the future site of the optic chiasm. After in vivo ablation of these chiasm neurons with a monoclonal antibody and complement, retinal axons did not cross the midline and stalled at approximately the entry site into the chiasm region. Thus, in the mouse, the presence of early-generated neurons that reside at the site of the future chiasm is required for formation of the optic chiasm by retinal ganglion cell axons.
authors.affiliation: Department of Ophthalmology, University of California, San Francisco 94143, USA.
authors.forename: D W
authors.initials: DW
authors.lastname: Sretavan
authors.forename: E
authors.initials: E
authors.lastname: Puré
authors.forename: M W
authors.initials: MW
authors.lastname: Siegel
authors.forename: L F
authors.initials: LF
authors.lastname: Reichardt
mesh_terms: D000818:Animals; D000911:Antibodies, Monoclonal; D001369:Axons / Q000502:physiology* / Q000648:ultrastructure; D002352:Carrier Proteins / Q000276:immunology; D018960:Hyaluronan Receptors; D007031:Hypothalamus / Q000166:cytology / Q000196:embryology; D051379:Mice; D008810:Mice, Inbred C57BL; D009474:Neurons / Q000502:physiology* / Q000648:ultrastructure; D009897:Optic Chiasm / Q000166:cytology / Q000196:embryology*; D009900:Optic Nerve / Q000196:embryology; D011956:Receptors, Cell Surface / Q000276:immunology; D016201:Receptors, Lymphocyte Homing / Q000276:immunology; D012160:Retina / Q000196:embryology; D012165:Retinal Ganglion Cells / Q000502:physiology*; D014795:Visual Pathways / Q000196:embryology*
chemical_list: D000911:Antibodies, Monoclonal; D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D011956:Receptors, Cell Surface; D016201:Receptors, Lymphocyte Homing