N-acetyltransferase activity--a susceptibility factor in human bladder carcinogenesis.
A higher proportion of slow acetylator phenotypes has previously been found among bladder cancer patients. In the present study carried out among 77 male bladder cancer patients and 80 non-cancer controls, 59.74% of the patients and 35% of the controls were slow acetylator phenotypes (p < 0.01). The odds of developing bladder cancer was also observed to be significantly higher among smokers than non-smokers (p < 0.01). The findings suggest that slow N-acetyl phenotype is a susceptibility factor in bladder carcinogenesis.
Dewan
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A
Department of Medical Toxicology, National Institute of Occupational Health, Meghani Nagar, Ahmedabad, Gujarat, India.
Chattopadhyay
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Kulkarni
P K
PK
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001191:Arylamine N-Acetyltransferase / Q000235:genetics / Q000378:metabolism*; D004198:Disease Susceptibility; D006801:Humans; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D012016:Reference Values; D012907:Smoking / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000201:enzymology*
D001191:Arylamine N-Acetyltransferase