A severe case of ovarian hyperstimulation syndrome despite the prophylactic administration of intravenous albumin.
OBJECTIVE
To evaluate the role of the recently suggested IV administration of human albumin solution as an effective preventive measure of severe ovarian hyperstimulation in high-risk patients.


METHODS
Presented here is, to the best of our knowledge, the first case of early severe ovarian hyperstimulation necessitating early transabdominal aspiration of ascites and intensive fluid and colloid (dextran and albumin) replacement, which developed despite administration of IV human albumin solution in an attempt to prevent severe ovarian hyperstimulation.


CONCLUSIONS
Because IV albumin does not prevent severe ovarian hyperstimulation in absolute terms, its use in high-risk patients should not lead one astray. Further research should be directed at investigating the fundamental cause of ovarian hyperstimulation syndrome and developing a reliable predictive test for this complication.
Orvieto
R
R
Department of Obstetrics and Gynecology, Golda Meir Medical Center, Hasharon Hospital, Petah Tikva, Israel.
Dekel
A
A
Dicker
D
D
Bar-Hava
I
I
Ben-Rafael
Z
Z
D000328:Adult; D001201:Ascites / Q000628:therapy; D003911:Dextrans / Q000627:therapeutic use; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D001239:Inhalation; D007275:Injections, Intravenous; D016471:Ovarian Hyperstimulation Syndrome / Q000503:physiopathology* / Q000517:prevention & control*; D012709:Serum Albumin / Q000627:therapeutic use*
D003911:Dextrans; D012709:Serum Albumin