[The anti-HCV assay in viral hepatitis and hepatoma and the relationship between HCV infection and blood transfusion].
Two hundred cases of various kinds of viral hepatitis and hepatocellular carcinoma were tested for serum anti-HCV. The positive rates of anti-HVC in patients with severe hepatitis and patients with cirrhosis were 42.86% and 46.15%, respectively. They were significantly higher than those in patients with other kinds of hepatitis (P < 0.05). The positive rate of anti-HCV was 67.5% in patients with posttransfusion hepatitis, 20.47% in healthy blood donors. In posttransfusion hepatitis B it was only 2.5%. Our results demonstrated that blood transfusion played an important role in transmitting HCV. Our findings also indicated that dual infection of HBV and HCV was important in the course of chronic hepatitis, cirrhosis and severe hepatitis. 50% of the anti-HCV positive patients with chronic hepatitis had slightly elevated serum alanine aminotransferase level. This showed that liver damage caused by HCV may be a chronic course.
Zhao
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Department of Infectious Diseases, First Teaching Hospital of Shanxi Medical College, Taiyuan.
Lang
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Xiang
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S
D000328:Adult; D006528:Carcinoma, Hepatocellular / Q000821:virology*; D005260:Female; D016174:Hepacivirus / Q000302:isolation & purification; D006506:Hepatitis A / Q000821:virology; D006508:Hepatitis Antibodies / Q000097:blood; D006509:Hepatitis B / Q000821:virology*; D006526:Hepatitis C / Q000635:transmission; D018937:Hepatitis C Antibodies; D006801:Humans; D008113:Liver Neoplasms / Q000821:virology*; D008297:Male; D008875:Middle Aged; D015163:Superinfection; D065227:Transfusion Reaction
D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies