Expression of tenascin during carcinogenesis and involution of hormone-dependent tissues.
Cytotactin/tenascin/hexabrachion, now referred to as tenascin-C (TN-C), is a hexameric glycoprotein of the extracellular matrix of mesenchymal tissue constituents. A high expression was found in embryonic development and during carcinogenesis of almost all organs. TN-C expression by the mesenchyme thereby appears to be induced by paracrine-acting, epithelial-derived (growth) factors. In normal adult organs there is little, if any, TN-C expression. In the human endometrium for instance, tenascin expression is low in the normal proliferative endometrium and undetectable in the normal secretory endometrium. In this paper, the appearance and expression of TN-C in hormone-dependent tissues, regressing hormone-dependent tissues, and tumors of the endometrium, breast and prostate is reviewed. Further, the regulation of TN-C expression is summarized and possible functions of TN-C during regression and carcinogenesis of hormone-dependent tissues are discussed.
Vollmer
G
G
Institut für Biochemische Endokrinologie, Medizinische Universität, Lübeck, Germany.
D000818:Animals; D017209:Apoptosis; D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology; D015816:Cell Adhesion Molecules, Neuronal / Q000096:biosynthesis*; D016889:Endometrial Neoplasms / Q000378:metabolism* / Q000473:pathology; D004846:Epithelial Attachment / Q000473:pathology; D016326:Extracellular Matrix Proteins / Q000096:biosynthesis*; D005260:Female; D006801:Humans; D008297:Male; D008648:Mesoderm / Q000378:metabolism / Q000473:pathology; D009376:Neoplasms, Hormone-Dependent / Q000378:metabolism* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000378:metabolism* / Q000473:pathology; D019063:Tenascin
D015816:Cell Adhesion Molecules, Neuronal; D016326:Extracellular Matrix Proteins; D019063:Tenascin