title: Cytotoxic ent-kaurene diterpenoids from three Isodon species.
abstract: From Isodon loxothyrsa, one new diterpenoid, loxothyrin A, together with one known diterpenoid, adenolin B, from I.pleiophyllus, three known diterpenoids, coetsoidins A, B and G, and from I. adenoloma, one known diterpenoid, longikaurin F, were isolated. The structure determination of loxothyrin A, and the unambiguous NMR spectral assignments of the known compounds were made by a combination of 1D and 2D NMR techniques and computer modelling calculations. The isolates showed potent cytotoxic activities.
authors.affiliation: Laboratory of Phytochemistry, Kunming Institute of Botany, Academia Sinica, Yunnan Province, P.R. China.
authors.forename: H D
authors.initials: HD
authors.lastname: Sun
authors.forename: Z W
authors.initials: ZW
authors.lastname: Lin
authors.forename: F D
authors.initials: FD
authors.lastname: Niu
authors.forename: L Z
authors.initials: LZ
authors.lastname: Lin
authors.forename: H B
authors.initials: HB
authors.lastname: Chai
authors.forename: J M
authors.initials: JM
authors.lastname: Pezzuto
authors.forename: G A
authors.initials: GA
authors.lastname: Cordell
mesh_terms: D000962:Antimalarials / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D004224:Diterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D045786:Diterpenes, Kaurane; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000201:enzymology; D009682:Magnetic Resonance Spectroscopy; D010944:Plants / Q000737:chemistry*; D018894:Reverse Transcriptase Inhibitors
chemical_list: D000962:Antimalarials; D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D045786:Diterpenes, Kaurane; D018894:Reverse Transcriptase Inhibitors; C002627:kaurene; D054303:HIV Reverse Transcriptase