title: Expression of fatty acid binding protein in the liver during pregnancy and lactation in the rat.
abstract: Expression of the liver fatty acid binding protein (L-FABP) has been studied in the liver of pregnant and lactating rats. The L-FABP concentration found in the cytosol by immuno-enzymatic assay (ELISA) was consistently higher in the dams during the pregnancy and the lactation than in the age-matched virgin females. Paradoxically, a decrease in the L-FABP mRNA level occurred in the maternal liver during the last days of the gestation. This level remained low on days 7 and 14 of the lactation. Since the transcription rate of the L-FABP gene was unchanged in the maternal liver, these data suggest a post-transcriptional regulation of the L-FABP during pregnancy and lactation in the rat. The nutritional adaptations occurring during pregnancy and lactation are not involved in this regulation since a chronic maternal food-restriction failed to correct these modifications. The mechanism of this regulation is presently unknown, but possibilities include hormonally mediated effects.
authors.affiliation: Laboratoire de Physiologie de la Nutrition, Ecole Nationale Supérieure de Biologie Appliquée à la Nutrition et à l'Alimentation, Université de Bourgogne, Dijon, France.
authors.forename: P
authors.initials: P
authors.lastname: Besnard
authors.forename: L
authors.initials: L
authors.lastname: Foucaud
authors.forename: A
authors.initials: A
authors.lastname: Mallordy
authors.forename: C
authors.initials: C
authors.lastname: Berges
authors.forename: R M
authors.initials: RM
authors.lastname: Kaikaus
authors.forename: A
authors.initials: A
authors.lastname: Bernard
authors.forename: N M
authors.initials: NM
authors.lastname: Bass
authors.forename: H
authors.initials: H
authors.lastname: Carlier
mesh_terms: D000818:Animals; D002352:Carrier Proteins / Q000378:metabolism*; D002149:Energy Intake; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D015870:Gene Expression; D007774:Lactation; D008099:Liver / Q000378:metabolism*; D018996:Myelin P2 Protein / Q000378:metabolism*; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D014158:Transcription, Genetic
chemical_list: D002352:Carrier Proteins; C493320:Fabp1 protein, mouse; C493321:Fabp1 protein, rat; C490174:Fabp7 protein, rat; D000071438:Fatty Acid-Binding Protein 7; D050556:Fatty Acid-Binding Proteins; D005227:Fatty Acids; D018996:Myelin P2 Protein; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins