title: [Granulocyte colony-stimulating factor: biologic effects and possibilities of therapeutic use].
abstract: This review is a brief overview on recent advances in biology as well as in the potential clinical application of recombinant methionil human granulocyte colony-stimulating factor (r-metHuG-CSF). Biologically active human granulocyte colony-stimulating factor is a recombinant human protein expressed in Escherichia coli. It is localized on membrane of stroma cells in molecules of extracellular matrix. R-metHuG-CSF increases the number of circulating neutrophils, and to a much lesser extent macrophages. The clinically relevant uses of r-metHuG-CSF at present lie in two general areas: neutropenia and febrile netropenia present in patients with non-myeloid malignant diseases induced by anticancer agents. R-metHuG-CSF produces dose-dependent and reversible side effects such as: musculoskeletal pain, urinary disorders, retention of fluid, pericarditis, dyspnea, hypoxia and hypotension.
authors.affiliation: Institut za farmakologiju, Medicinski fakultet, Beograd.
authors.forename: D
authors.initials: D
authors.lastname: Jovanović-Mićić
authors.forename: D B
authors.initials: DB
authors.lastname: Beleslin
authors.forename: R
authors.initials: R
authors.lastname: Samardzić
authors.forename: S
authors.initials: S
authors.lastname: Bosnjak
mesh_terms: D016179:Granulocyte Colony-Stimulating Factor / Q000502:physiology* / Q000627:therapeutic use; D006801:Humans
chemical_list: D016179:Granulocyte Colony-Stimulating Factor