title: Staging and recurrence of disease in squamous cell carcinoma of the vulva.
abstract: In order to determine the prognostic significance of applying the revised FIGO staging system and identify factors contributing to survival after documentation of recurrent disease, a retrospective chart review of our vulvar cancer population was performed. Over a 17-year interval 135 patients were uniformly treated with primary surgical treatment consisting of radical vulvectomy and bilateral groin dissection. Factors contributing to disease-free survival were analyzed using a Cox proportional hazards model. Covariates of survival after recurrence of disease were analyzed using the log-rank method. Neither the clinical assessment of the groin nodes, nor the presence or absence of perineal involvement were related to outcome. Only lesion size and surgical status of the inguinal nodes were significant predictors of disease-free survival (P = 0.02 and P = 0.03, respectively). In addition, there was a statistically significant relationship between the extent of groin involvement (negative, unilateral positive, and bilateral positive nodes) and associated decrement in disease-free survival (P = 0.01). Thirty patients developed recurrence of disease from 2.0 to 47.3 months following surgery. The location of the recurrence, interval from primary therapy to recurrence, and status of the groin nodes at initial surgery were significant prognostic factors in subsequent survival. The revised staging system demonstrated an improvement in patient stratification compared to the criteria of the prior classification. The data are also consistent with the distinction made between Stage III and IV disease in the new classification. The status of the groin nodes at original surgery remained an important prognostic factor even in those patients who later demonstrated recurrence of disease.
authors.affiliation: Department of Obstetrics and Gynecology, M.S. Hershey Medical Center, Pennsylvania State University, Hershey 17033, USA.
authors.forename: B
authors.initials: B
authors.lastname: Ndubisi
authors.forename: P F
authors.initials: PF
authors.lastname: Kaminski
authors.forename: G
authors.initials: G
authors.lastname: Olt
authors.forename: J
authors.initials: J
authors.lastname: Sorosky
authors.forename: K
authors.initials: K
authors.lastname: Singapuri
authors.forename: T
authors.initials: T
authors.lastname: Hackett
authors.forename: D
authors.initials: D
authors.lastname: Hetzel
authors.forename: R
authors.initials: R
authors.lastname: Zaino
authors.forename: R
authors.initials: R
authors.lastname: Mortel
authors.forename: E
authors.initials: E
authors.lastname: Podczaski
mesh_terms: D000206:Actuarial Analysis; D002294:Carcinoma, Squamous Cell / Q000473:pathology*; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology*; D009367:Neoplasm Staging; D011379:Prognosis; D012189:Retrospective Studies; D014846:Vulvar Neoplasms / Q000473:pathology*