Molecular basis of inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) polymorphism.
A genetic polymorphism of the inter-alpha-trypsin inhibitor heavy chain H1 (ITIH1) was analyzed at the nucleic acid level. Three common alleles, ITIH1*1, ITIH1*2 and ITIH1*3, were characterized by mutations at codons 551 and 561 in exon 14. ITIH1*1 was characterized by GAG (Glu) at codon 551 and CAG (Gln) at codon 561, ITIH1*2, by GTG (Val) and CGG (Arg), and ITIH1*3, by GAG (Glu) and CGG (Arg).
Ding
M
M
Department of Forensic Medicine, Yamagata University School of Medicine, Japan.
Umetsu
K
K
Yuasa
I
I
Sato
M
M
Harada
A
A
Suzuki
T
T
D000510:Alpha-Globulins / Q000235:genetics*; D000595:Amino Acid Sequence; D001483:Base Sequence; D003062:Codon; D004247:DNA / Q000032:analysis; D017931:DNA Primers / Q000737:chemistry; D006801:Humans; D008967:Molecular Biology; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D014361:Trypsin Inhibitors / Q000235:genetics*
D000510:Alpha-Globulins; D003062:Codon; D017931:DNA Primers; D014361:Trypsin Inhibitors; C011877:inter-alpha-inhibitor; D004247:DNA