Probucol prevents the progression of fatty liver in MSG obese mice.
We investigated the effect of Probucol in preventing fatty liver in monosodium-L-glutamate (MSG) treated obese mice and control mice fed a high fat diet. MSG mice became significantly obese 9 weeks after birth with higher levels of serum blood glucose, total cholesterol, HDL-cholesterol, GPT, and cholinesterase, and had greater triglyceride contents in their livers relative to control mice. Morphologically, MSG obese mice also had a marked fatty liver. Administration of Probucol mixed with the high fat diet for 2 weeks significantly decreased the serum levels of total cholesterol and HDL-cholesterol, and liver triglyceride contents in both MSG and control mice. Morphologically, the livers were less fatty after Probucol treatment. These results suggest that Probucol prevents the development of fatty liver, and in addition reduces hypercholesterolemia.
Yoshida
T
T
First Department of Internal Medicine, Kyoto Prefectural University of Medicine, Japan.
Yoshioka
K
K
Sakane
N
N
Umekawa
T
T
Kondo
M
M
D000818:Animals; D000924:Anticholesteremic Agents / Q000627:therapeutic use*; D001786:Blood Glucose / Q000032:analysis; D002784:Cholesterol / Q000032:analysis / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D002802:Cholinesterases / Q000097:blood; D018450:Disease Progression; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005234:Fatty Liver / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D005260:Female; D008099:Liver / Q000737:chemistry; D051379:Mice; D008813:Mice, Inbred ICR; D008820:Mice, Obese; D009765:Obesity / Q000139:chemically induced / Q000150:complications / Q000503:physiopathology*; D011341:Probucol / Q000627:therapeutic use*; D012970:Sodium Glutamate / Q000494:pharmacology*; D014280:Triglycerides / Q000032:analysis / Q000097:blood
D000924:Anticholesteremic Agents; D001786:Blood Glucose; D008076:Cholesterol, HDL; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; D002784:Cholesterol; D002802:Cholinesterases; D011341:Probucol; D012970:Sodium Glutamate