Search for naturally occurring substances to prevent the complications of diabetes. II. Inhibitory effect of coumarin and flavonoid derivatives on bovine lens aldose reductase and rabbit platelet aggregation.
An EtOAc extract of Artemisiae Capillari Spica inhibited both bovine lens aldose reductase (bovine-LAR) and rabbit platelet aggregation. Two simple coumarins, scoparone (1) and scopoletin (2), and three flavonoids, capillarisin (21), cirsimaritin (22) and rhamnocitrin (23), were isolated from this extract. Scoparone (1) and scopoletin (2) exhibit a potent inhibitory effect on rabbit platelet aggregation induced by four types of agent, ADP, PAF, sodium arachidonate and/or collagen. Capillarisin (21) exhibits a potent inhibitory effect on bovine-LAR. In addition, thirteen simple coumarins, five coumarin glycosides and two flavonoids were tested for their inhibitory effect against bovine-LAR and rabbit platelet aggregation.
Okada
Y
Y
Department of Pharmacognosy and Phytochemistry, Meiji College of Pharmacy, Tokyo, Japan.
Miyauchi
N
N
Suzuki
K
K
Kobayashi
T
T
Tsutsui
C
C
Mayuzumi
K
K
Nishibe
S
S
Okuyama
T
T
D000449:Aldehyde Reductase / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D003374:Coumarins / Q000494:pharmacology*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005419:Flavonoids / Q000494:pharmacology*; D066298:In Vitro Techniques; D007908:Lens, Crystalline / Q000187:drug effects / Q000201:enzymology*; D008297:Male; D010946:Plants, Medicinal / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship
D003374:Coumarins; D004791:Enzyme Inhibitors; D005419:Flavonoids; D010975:Platelet Aggregation Inhibitors; D000449:Aldehyde Reductase