Regulation of development, survival and neoplastic growth of mast cells through the c-kit receptor.
Signaling through the c-kit receptor tyrosine kinase (Kit) is essential for development and survival of mast cells but not of basophils. Moreover, we recently found an activation mutation of Kit in several tumor mast cell lines.
Kitamura
Y
Y
Department of Pathology, Osaka University Medical School, Japan.
Tsujimura
T
T
Jippo
T
T
Kasugai
T
T
Kanakura
Y
Y
D000818:Animals; D001491:Basophils / Q000166:cytology; D002454:Cell Differentiation; D002470:Cell Survival; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D007946:Leukemia, Mast-Cell / Q000473:pathology; D008407:Mast Cells / Q000166:cytology* / Q000473:pathology; D012515:Mast-Cell Sarcoma / Q000473:pathology; D051379:Mice; D008822:Mice, Transgenic; D009559:Nippostrongylus; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D011518:Proto-Oncogene Proteins / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D019009:Proto-Oncogene Proteins c-kit; D051381:Rats; D011922:Rats, Mutant Strains; D011923:Rats, Nude; D020794:Receptor Protein-Tyrosine Kinases / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D016184:Receptors, Colony-Stimulating Factor / Q000172:deficiency / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction; D017206:Strongylida Infections / Q000276:immunology / Q000473:pathology; D014407:Tumor Cells, Cultured
D011518:Proto-Oncogene Proteins; D016184:Receptors, Colony-Stimulating Factor; D019009:Proto-Oncogene Proteins c-kit; D020794:Receptor Protein-Tyrosine Kinases