title: [Systemic integration of dominating motivation].
abstract: The paper analyzes the investigations into the central architectonics of biological motivations, which have been performed by the P.K. Anokhin scientific school. Each biological motivation is postulated to be a result of specific integration of heterochemical mechanisms of biological motivations. The chemical plasticity of biological motivations is evidenced by the findings of the duplication of different neurotransmitters in cortical-subcortical interrelations, as well as the potentialities of the chemical rearrangement ("chemical compensation") of neurotransmitter mechanisms of biological motivations in case of bilateral failure of hypothalamic motivational centers of the hypothalamus. Some cerebral oligopeptides are found to be able to temporarily and selectively modify the pattern of motivational behavioral responses evoked by electric stimulation of various hypothalamic formations. It is concluded that the biological motivations are a result of the integrative performance of the whole brain wherein hypothalamic pacemakers play the leading but not final role.
authors.forename: V G
authors.initials: VG
authors.lastname: Zilov
mesh_terms: D000818:Animals; D001921:Brain / Q000502:physiology*; D004924:Escape Reaction; D006801:Humans; D007031:Hypothalamus / Q000502:physiology; D009042:Motivation; D018377:Neurotransmitter Agents / Q000502:physiology; D009842:Oligopeptides / Q000502:physiology; D011817:Rabbits
chemical_list: D018377:Neurotransmitter Agents; D009842:Oligopeptides