title: Antinociceptive effects of clebopride in the mouse.
abstract: 1. The effects of the substituted benzamide clebopride, an orthopramide, on nociception of chemical and thermal stimuli were investigated. 2. Clebopride (0.5, 1.0 and 2.0 mg/kg) promoted significant analgesia in the tail-flick and hot-plate tests and against abdominal constrictions produced by acetic acid or acetylcholine. 3. The analgesic effects of clebopride were not influenced by pretreatment with naltrexone (1-3 mg/kg). 4. The results suggest that clebopride induces analgesia against both thermal and chemical nociceptive stimuli, which is not mediated via opioid mechanisms.
authors.affiliation: Department of Pharmacology, University of Santa Catarina, Florianopolis, Brazil.
authors.forename: S C
authors.initials: SC
authors.lastname: Bittencourt
authors.forename: T C
authors.initials: TC
authors.lastname: De Lima
authors.forename: G S
authors.initials: GS
authors.lastname: Morato
mesh_terms: D000085:Acetates; D019342:Acetic Acid; D000109:Acetylcholine; D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D000932:Antiemetics / Q000494:pharmacology*; D001549:Benzamides / Q000494:pharmacology*; D006358:Hot Temperature; D008297:Male; D051379:Mice; D009271:Naltrexone / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D004856:Postural Balance / Q000187:drug effects; D011930:Reaction Time / Q000187:drug effects
chemical_list: D000085:Acetates; D000700:Analgesics; D000932:Antiemetics; D001549:Benzamides; D009271:Naltrexone; C014417:clebopride; D000109:Acetylcholine; D019342:Acetic Acid