Serum neopterin concentrations in Wegener's granulomatosis correlate with vasculitis activity.
Raised serum neopterin concentrations were found in 13 of 27 patients (47%) with Wegener's granulomatosis. The neopterin concentrations significantly correlated with the Birmingham Vasculitis Activity Score as well as with the erythrocyte sedimentation rate and C-reactive protein. High serum neopterin levels were also associated with infectious complications. The finding of increased neopterin concentrations in patients with Wegener's granulomatosis supports the role of cell-mediated immunity and particularly of activated macrophages in the pathogenesis of the disease.
Nassonov
E
E
Cardiology Research Center, Moscow, Russia.
Samsonov
M
M
Beketova
T
T
Semenkova
L
L
Wachter
H
H
Fuchs
D
D
D000328:Adult; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood; D001708:Biopterins / Q000031:analogs & derivatives* / Q000097:blood; D018450:Disease Progression; D005260:Female; D005455:Fluorescent Antibody Technique; D005500:Follow-Up Studies; D014890:Granulomatosis with Polyangiitis / Q000097:blood* / Q000276:immunology; D006801:Humans; D008297:Male; D019798:Neopterin; D011863:Radioimmunoassay
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D001708:Biopterins; D019798:Neopterin