Exocytotic Ca2+ channels in mammalian central neurons.
Intracellular Ca2+ initiates physiological events as diverse as gene transcription, muscle contraction, cell division and exocytosis. Predictably, the metabolic machinery that elicits and responds to changes in intracellular Ca2+ is correspondingly heterogeneous. This review focuses on one element of this complex web that is of particular importance to neurobiologists: identifying which members of the voltage-dependent Ca(2+)-channel superfamily are responsible for the Ca2+ that enters nerve terminals and elicits vesicular release of chemical transmitters.
Dunlap
K
K
Dept of Physiology, Tufts University School of Medicine, Boston, MA 02111, USA.
Luebke
J I
JI
Turner
T J
TJ
D000595:Amino Acid Sequence; D000818:Animals; D015220:Calcium Channels / Q000235:genetics / Q000378:metabolism*; D020864:Calcium Channels, N-Type; D002490:Central Nervous System / Q000166:cytology* / Q000378:metabolism*; D005089:Exocytosis / Q000502:physiology*; D006801:Humans; D008969:Molecular Sequence Data; D009474:Neurons / Q000378:metabolism* / Q000502:physiology
D015220:Calcium Channels; D020864:Calcium Channels, N-Type