Somatostatin receptor activation of cellular effector systems.
Somatostatin (SRIF) induces its multiple biological actions by interacting with a family of receptors, referred to as SSTR1-SSTR5. These receptors are capable of associating with particular guanine nucleotide binding proteins to couple the receptors to distinct cellular effector systems. Therefore, G proteins have an important role in directing SRIF signalling and may provide the molecular basis for the diverse cellular actions of SRIF.
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Department of Pharmacology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
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D000262:Adenylyl Cyclases / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D002455:Cell Division; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D007473:Ion Channels / Q000378:metabolism; D008969:Molecular Sequence Data; D012326:RNA Splicing; D017481:Receptors, Somatostatin / Q000235:genetics / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*; D013004:Somatostatin / Q000378:metabolism
D007473:Ion Channels; D017481:Receptors, Somatostatin; D013004:Somatostatin; D019204:GTP-Binding Proteins; D000262:Adenylyl Cyclases