title: Ethylene oxide as a major factor in DNA and RNA evolution.
abstract: Gaseous ethylene oxide (EO) is genotoxic in a wide variety of biological systems and carcinogenic in rats and mice. The major product of EO reaction with DNA is 7-(2-hydroxyethyl)guanine. In the organism, EO originates through biotransformation of ethylene. Ethylene in higher plants has been found to be a key factor in the control of a number of developmental processes including senescence, abscission and ripening. Ethylene oxide can participate in the transition of pyrimidine bases from C to T or U and from U to C. Thus, EO may provide a key approach to the study of DNA and RNA evolution. The studies here suggest a role for EO in modulating multiple messenger pathways in DNA and RNA functions. Perhaps surprisingly, it exerts two quite different activities, expressed in diverse cells. On the one hand, EO causes mutagenesis and carcinogenesis if available in excess. On the other, at low concentrations it can mediate repair of DNA at replication and RNA at transcription and translation. The report provides substantial evidence that EO can also play a very important role in the DNA and RNA evolution of whole biological systems. This important effect of EO needs to be understood more completely.
authors.affiliation: Research Institute of Occupational Medicine, University of Bochum, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Marczynski
authors.forename: W
authors.initials: W
authors.lastname: Marek
authors.forename: X
authors.initials: X
authors.lastname: Baur
mesh_terms: D000818:Animals; D005075:Biological Evolution; D001711:Biotransformation; D004247:DNA / Q000737:chemistry* / Q000187:drug effects; D004249:DNA Damage; D004260:DNA Repair; D004777:Environment; D005027:Ethylene Oxide / Q000493:pharmacokinetics / Q000633:toxicity; D018521:Plant Physiological Phenomena; D012313:RNA / Q000737:chemistry* / Q000187:drug effects; D015398:Signal Transduction
chemical_list: D012313:RNA; D004247:DNA; D005027:Ethylene Oxide