title: Prostate-specific antigen concentration: influence of age and ethnicity.
abstract: This pilot study evaluated the influence of age and ethnicity on serum prostate-specific antigen (PSA) concentration in Asian and white men without a clinical diagnosis of prostate cancer. Between October and December 1993, 1260 patients who underwent serum PSA determination (Hybritech Tandem-R assay, San Diego, California) at Straub Clinic & Hospital were retrospectively analyzed. Of these, 885 (70%) men aged 40 to 79 years were either Asian (Chinese, Filipino, Japanese, and Korean) or white and had a serum PSA less than 10.0 ng/ml. The PSA for the entire group was 2.1 +/- 2.0 ng/ml (mean +/- SD). PSA correlated with age (r = 0.31, p = 0.0001) and age accounted for 10% of the variance in serum PSA. Using the regression formula, serum PSA increased 2.5% (0.06 ng/ml) per year of age. The entire study group was about equally divided between whites (49%) and Asians (51%). Nearly three-fourths of the Asian men were Japanese. The mean PSA was very close in the Asian and white groups. There was no direct correlation between serum PSA and ethnicity (r = 0.03; p = 0.3201). Ethnicity contributed 0.1% of the variance in PSA. In conclusion, this preliminary study suggests serum PSA increases with age in Asian and white men without a clinical diagnosis of prostate cancer. No difference was found in PSA between men of Asian and white ethnicity.
authors.affiliation: Hawaii MEDTEP Research Center, Pacific Health Research Institute, Straub Clinic, Honolulu 96813, USA.
authors.forename: L D
authors.initials: LD
authors.lastname: Madanay
authors.forename: D B
authors.initials: DB
authors.lastname: Johnson
authors.forename: L A
authors.initials: LA
authors.lastname: Miyamoto
authors.forename: F I
authors.initials: FI
authors.lastname: Gilbert
mesh_terms: D000328:Adult; D017677:Age Distribution; D000367:Age Factors; D000368:Aged; D001213:Asian / Q000706:statistics & numerical data*; D003430:Cross-Sectional Studies; D006254:Hawaii / Q000453:epidemiology; D006801:Humans; D007564:Japan / Q000208:ethnology; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000139:chemically induced; D012189:Retrospective Studies; D044465:White People / Q000706:statistics & numerical data*
chemical_list: D017430:Prostate-Specific Antigen