Consistent presence of isochromosome 7q in hepatosplenic T gamma/delta lymphoma: a new cytogenetic-clinicopathologic entity.
Peripheral T-cell lymphoma (PTL), which is characterized by hepatosplenic presentation and the gamma/delta T-cell receptor (TCR) phenotype on the malignant cells, is a rare but distinct subtype of non-Hodgkin's lymphomas. Little is known about the chromosomal changes in these lymphomas. We report the cytogenetic analysis of three patients who had neoplastic proliferation of T gamma/delta cells in the spleen, bone marrow, and liver, but not in lymph nodes or skin. Isochromosome 7q and trisomy 8 were observed in all three patients. Isochromosome 7q as the sole abnormality has been previously reported in one patient with similar clinicopathologic features. It is suggested that i(7q) is a primary, nonrandom chromosomal abnormality in hepatosplenic T gamma/delta PTL.
Wang
C C
CC
Department of Internal Medicine, National Taiwan University Hospital, Taipei, R.O.C.
Tien
H F
HF
Lin
M T
MT
Su
I J
IJ
Wang
C H
CH
Chuang
S M
SM
Shen
M C
MC
Liu
C H
CH
D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D017809:Fatal Outcome; D005819:Genetic Markers; D006801:Humans; D018404:Isochromosomes; D008113:Liver Neoplasms / Q000235:genetics* / Q000276:immunology; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics* / Q000276:immunology; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis; D013154:Spleen / Q000276:immunology / Q000473:pathology; D013160:Splenic Neoplasms / Q000235:genetics* / Q000276:immunology; D014314:Trisomy
D015703:Antigens, CD; D005819:Genetic Markers; D016692:Receptors, Antigen, T-Cell, gamma-delta