title: Absolute stereostructures of hovenidulciosides A1 and A2, bioactive novel triterpene glycosides from hoveniae semen seu fructus, the seeds and fruit of Hovenia dulcis Thunb.
abstract: Two bioactive novel triterpene glycosides named hovenidulciosides A1 and A2 have been isolated from a Chinese natural medicine, Hoveniae Semen Seu Fructus, the seeds and fruit of Hovenia dulcis Thunb. (Rhamnaceae). The absolute stereostructures of hovenidulciosides A1 and A2 with a migrated 16,17-seco-dammarane skeleton have been determined on the basis of chemical and physicochemical evidence which included the X-ray crystallographic analysis of the p-bromobenzoate of their common aglycone, hovenidulcigenin A. Hovenidulciosides A1 and A2 exhibited inhibitory activity on the histamine release from rat mast cells induced by compound 48/80 or calcium ionophore A-23187.
authors.affiliation: Kyoto Pharmaceutical University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Yoshikawa
authors.forename: T
authors.initials: T
authors.lastname: Ueda
authors.forename: O
authors.initials: O
authors.lastname: Muraoka
authors.forename: H
authors.initials: H
authors.lastname: Aoyama
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
authors.forename: H
authors.initials: H
authors.lastname: Shimoda
authors.forename: J
authors.initials: J
authors.lastname: Yamahara
authors.forename: N
authors.initials: N
authors.lastname: Murakami
mesh_terms: D000818:Animals; D000001:Calcimycin / Q000037:antagonists & inhibitors / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004365:Drugs, Chinese Herbal / Q000737:chemistry*; D005638:Fruit / Q000737:chemistry; D006636:Histamine Release / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism; D015394:Molecular Structure; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D012503:Saponins / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012639:Seeds / Q000737:chemistry; D013237:Stereoisomerism; D014315:Triterpenes; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D004365:Drugs, Chinese Herbal; D012503:Saponins; D014315:Triterpenes; C093742:hovenidulcioside A1; C093877:hovenidulcioside A2; D000001:Calcimycin; D003189:p-Methoxy-N-methylphenethylamine