title: Osteosarcoma following radiation treatment for meningioma: report of a case and effective treatment with chemotherapy.
abstract: A case of effective chemotherapy in postirradiation sarcoma is reported. A 30-year-old woman underwent a subtotal resection of a benign mixed meningioma followed by a course of radiotherapy. Five years later she developed a skull tumor which was resected. Histological study showed sarcomatous change corresponding most likely to a postirradiation osteosarcoma. Adjuvant chemotherapy (methotrexate, carboplatin, and VP16) was given. A progression occurred 8 months later and the patient was treated unsuccessfully with tamoxifen, LHRH, and later with high dose methotrexate and carboplatin. Six months later a lung metastasis was discovered and she received four cycles of IVP (ifosfamide, vepeside, cisplatin) alternating with IVA (ifosfamide, vepeside, adriamycin). Within 4 months the primary and lung tumours had decreased substantially without evidence of progression at follow-up 5 months later. We conclude that IVP/IVA regimen is a potentially useful therapy when an osteosarcoma of the skull is in progression.
authors.affiliation: Clinique Neurologique (Pr Brunet), Hôpital de la Salpetriere, Paris, France.
authors.forename: A F
authors.initials: AF
authors.lastname: Carpentier
authors.forename: J V
authors.initials: JV
authors.lastname: Chantelard
authors.forename: D
authors.initials: D
authors.lastname: Henin
authors.forename: M
authors.initials: M
authors.lastname: Poisson
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D001859:Bone Neoplasms / Q000188:drug therapy*; D016190:Carboplatin / Q000008:administration & dosage; D002945:Cisplatin / Q000008:administration & dosage; D003609:Dactinomycin / Q000008:administration & dosage; D005047:Etoposide / Q000008:administration & dosage; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D008175:Lung Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008577:Meningeal Neoplasms / Q000532:radiotherapy*; D008579:Meningioma / Q000532:radiotherapy*; D008727:Methotrexate / Q000008:administration & dosage; D009381:Neoplasms, Radiation-Induced / Q000188:drug therapy*; D016609:Neoplasms, Second Primary / Q000188:drug therapy*; D012516:Osteosarcoma / Q000188:drug therapy*; D013629:Tamoxifen / Q000627:therapeutic use; D014057:Tomography, X-Ray Computed; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D013629:Tamoxifen; D003609:Dactinomycin; D007987:Gonadotropin-Releasing Hormone; D014750:Vincristine; D005047:Etoposide; D016190:Carboplatin; D002945:Cisplatin; D007069:Ifosfamide; D008727:Methotrexate