Significance of urinalysis for subsequent kidney and urinary tract disorders in mass screening of adults.
To evaluate dipstick urinalysis as a predictor of subsequent kidney and urinary tract disorders in apparently healthy adults, we designed a cross-sectional, prospective, and retrospective study within a cohort. The severity of proteinuria was significantly (p < 0.01) associated with the amount of pathological casts, whereas hematuria without proteinuria was not. The frequency of subsequent serum creatinine increase (0.3 mg/dl/5 years or more) was significantly enhanced (from 0.4% to 7.3% along with the severity of proteinuria, whereas it was not related to the severity of hematuria. Patients who subsequently developed renal failure and glomerulonephritis exhibited hematuria (11.1-32.1%) less frequent than proteinuria (62.3-83.3%). Even those with renal tumors or stones showed infrequent (14.3-27.9%) hematuria. Thus, urine protein and occult blood have different implications in mass screening.
Kawamura
T
T
Department of Preventive Medicine, Nagoya University School of Medicine.
Ohta
T
T
Ohno
Y
Y
Wakai
K
K
Aoki
R
R
Tamakoshi
A
A
Maeda
K
K
Mizuno
Y
Y
D000328:Adult; D000368:Aged; D015331:Cohort Studies; D003404:Creatinine / Q000097:blood; D003430:Cross-Sectional Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007674:Kidney Diseases / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D015995:Prevalence; D011379:Prognosis; D011446:Prospective Studies; D011934:Reagent Strips; D012189:Retrospective Studies; D016482:Urinalysis / Q000379:methods*; D014570:Urologic Diseases / Q000097:blood / Q000175:diagnosis* / Q000453:epidemiology
D011934:Reagent Strips; D003404:Creatinine