Direct preparation and meiotic analysis of human semen.
A meiotic study of human semen specimens was carried out in 60 cases. Among them, 20 were normal controls, 20 suffered from infertility, and 20 had a history of recurrent spontaneous abortions. Of the cases of infertility and abortion, 50% were found to have numerical and/or structural chromosomal aberrations in spite of the normal blood karyotype. It is suggested that chromosomal aberrations may be the cause of sterility and abortion. The success rate of semen chromosome G-banding in the infertility, abortion and control groups was 70%, 55% and 25% respectively. The semen samples of three cases of heterozygous carriers with reciprocal chromosomal translocation were also studied. The ring quadrivalents were identified in all cases. The results may explain the recurrent abortions in these patients.
Jiang
J
J
Department of Pediatrics, Ruijin Hospital, Shanghai Second Medical University.
Wang
S
S
Chen
R
R
D000026:Abortion, Habitual; D000328:Adult; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000235:genetics*; D008297:Male; D008540:Meiosis; D008875:Middle Aged; D011247:Pregnancy; D012661:Semen / Q000166:cytology*; D014178:Translocation, Genetic