[In vitro fertilization failures related to a sperm hyperactivation defect: indication for microinjection?].
Development of hyperactivated motility is considered as necessary for penetration through zona pellucida. In a study concerning 114 IVF attempts, we could not establish a significant correlation between fertilization rate and hyperactivation rate (HA). On the contrary, most fertilization failures (16/21) we found for HA values < 10%. 10 of such couples could benefit of ICSI for the next attempt: fertilization rates were strictly similar to the general rate observed for ICSI in our group (48%).
Guérin
J F
JF
Hôpital Edouard Herriot, Lyon.
Gallot-Lavallée
P
P
Lornage
J
J
Pinatel
M C
MC
Lejeune
H
H
Boulieu
D
D
Bied
V
V
Payan
F
F
D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D006801:Humans; D008297:Male; D008845:Microinjections / Q000379:methods; D018579:Patient Selection; D011247:Pregnancy; D011256:Pregnancy Outcome; D013081:Sperm Motility; D013094:Spermatozoa / Q000002:abnormalities*; D017211:Treatment Failure