Cytotoxic biflavonoids from Selaginella willdenowii.
Bioactivity-guided fractionation of the leaves of Selaginella willdenowii afforded three known biflavones, 4',7"-di-O-methylamentoflavone, isocryptomerin and 7"-O-methylrobustaflavone, that were significantly cytotoxic against a panel of human cancer cell lines. Non-cytotoxic isolates were also obtained, namely, amentoflavone, bilobetin, robustaflavone and 2",3"-dihydroisocryptomerin, a new dihydrobiflavone. The structure for the new biflavonoid was unambiguously assigned by a combination of spectroscopic methods.
Silva
G L
GL
Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA.
Chai
H
H
Gupta
M P
MP
Farnsworth
N R
NR
Cordell
G A
GA
Pezzuto
J M
JM
Beecher
C W
CW
Kinghorn
A D
AD
D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000633:toxicity; D002460:Cell Line; D005419:Flavonoids / Q000302:isolation & purification* / Q000633:toxicity*; D006801:Humans; D008175:Lung Neoplasms; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D015394:Molecular Structure; D009904:Optical Rotation; D018515:Plant Leaves; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D005419:Flavonoids