Molecular mechanisms underlying functional T-cell unresponsiveness.
Evidence from tissue culture experiments and in vivo studies indicates that certain forms of antigen presentation render T cells unresponsive to subsequent antigenic stimulation. Great progress has been made recently in understanding the induction, maintenance, and in vivo relevance of this unresponsive state, called clonal anergy.
Mueller
D L
DL
University of Minnesota Medical School, Department of Medicine, Minneapolis 55455, USA.
Jenkins
M K
MK
D000818:Animals; D002478:Cells, Cultured; D006801:Humans; D007108:Immune Tolerance; D007121:Immunocompetence; D007376:Interleukin-2 / Q000096:biosynthesis / Q000276:immunology; D051379:Mice; D008822:Mice, Transgenic; D018448:Models, Immunological; D015398:Signal Transduction / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D007376:Interleukin-2