title: Cytokine production and requirements during T-cell development.
abstract: Cytokines have been presumed to play an important role during T-cell development, but until recently formal proof has been missing. Most cytokine-knockout mice show apparently normal intrathymic T-cell development. The exception to this is IL-7, as both IL-7 and IL-7R alpha knockout mice show abnormally low thymic cellularity, making IL-7 the first cytokine shown to be necessary for normal intrathymic T-cell development.
authors.affiliation: Immunology Department, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94304-1104, USA.
authors.forename: A
authors.initials: A
authors.lastname: Zlotnik
authors.forename: T A
authors.initials: TA
authors.lastname: Moore
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000276:immunology*; D016207:Cytokines / Q000096:biosynthesis* / Q000276:immunology; D051379:Mice; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism*
chemical_list: D016207:Cytokines