title: Interferon induction in swine lymphocyte antigen-defined miniature pigs.
abstract: Interferon was induced in two groups of swine lymphocyte antigen (SLA)-defined miniature pigs with polyinosinic: polycytidylic acid complexed with poly-L-lysine and carboxymethylcellulose. The group 1 pigs were low antibody-response phenotypes (SLAa/a, SLAa/c, SLAc/c), and the group 2 pigs were high antibody-response phenotypes (SLAd/d, SLAd/g, SLAg/g). Six hours after induction the antiviral tires were not influenced by the SLA group, but higher titres were observed in females. Higher antiviral titres were found in group 2 pigs before treatment and 24 hours after treatment, and higher titres were found in female pigs. The antiviral titres before and after treatment were also influenced by the sire. Group 2 pigs had a lower total leucocyte counts before treatment, and there was a significant reduction in leucocyte numbers in both groups six hours after induction, due mainly to a large reduction in lymphocyte counts.
authors.affiliation: Department of Veterinary Microbiology and Immunology, University of Guelph, Canada.
authors.forename: L T
authors.initials: LT
authors.lastname: Jordan
authors.forename: J B
authors.initials: JB
authors.lastname: Derbyshire
authors.forename: B A
authors.initials: BA
authors.lastname: Mallard
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000276:immunology; D005260:Female; D006649:Histocompatibility Antigens / Q000276:immunology*; D007369:Interferon Inducers / Q000494:pharmacology; D007372:Interferons / Q000096:biosynthesis*; D008214:Lymphocytes / Q000276:immunology*; D010641:Phenotype; D013552:Swine; D013556:Swine, Miniature / Q000276:immunology*; D014721:Vesicular stomatitis Indiana virus / Q000276:immunology
chemical_list: D000956:Antigens, Viral; D006649:Histocompatibility Antigens; D007369:Interferon Inducers; D007372:Interferons