Distribution of secretoneurin-like immunoreactivity in comparison with that of substance P in the human spinal cord.
Secretoneurin (SN), a neuropeptide of 33 amino acids, was determined in comparison with substance P (SP) by immunocytochemistry in normal human spinal cord. The density of secretoneurin-like immunoreactivity (SN-IR) was high in the superficial dorsal horn and in the lateral column of autonomic arcs. The ventral horn displayed low to moderate density of SN-IR and prominently outlined motoneurons. The congruent distribution of SN and SP to the termination of primary afferents may indicate that SN is involved in modulation of pain.
Telser
S
S
Department of Psychiatry, University of Innsbruck, Austria.
Marksteiner
J
J
Hinterhuber
H
H
Saria
A
A
D005726:Ganglia, Parasympathetic / Q000378:metabolism; D005728:Ganglia, Sympathetic / Q000378:metabolism; D006801:Humans; D007150:Immunohistochemistry; D009412:Nerve Fibers / Q000378:metabolism / Q000648:ultrastructure; D009479:Neuropeptides / Q000378:metabolism*; D053381:Secretogranin II; D013116:Spinal Cord / Q000378:metabolism*; D013373:Substance P / Q000378:metabolism*
D009479:Neuropeptides; D053381:Secretogranin II; C081159:secretoneurin; D013373:Substance P