Factor VIII, HIV and AIDS in haemophiliacs: an analysis of their relationship.
In this review, the association between the Acquired Immune Deficiency Syndrome (AIDS) and haemophilia has been carefully examined, especially the data that have been interpreted as indicating transmission of the human immunodeficiency virus (HIV) to the recipients of purportedly contaminated factor VIII preparations. In our view, the published data do not prove the hypothesis that such transmission occurs, and therefore HIV cannot account for AIDS in haemophiliacs.
Papadopulos-Eleopulos
E
E
Department of Medical Physics, Royal Perth Hospital, Western Australia.
Turner
V F
VF
Papadimitriou
J M
JM
Causer
D
D
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000209:etiology / Q000635:transmission*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D004340:Drug Contamination; D005169:Factor VIII / Q000009:adverse effects* / Q000302:isolation & purification; D006678:HIV / Q000201:enzymology / Q000302:isolation & purification; D015483:HIV Antibodies / Q000097:blood; D016655:HIV Core Protein p24 / Q000302:isolation & purification; D006467:Hemophilia A / Q000150:complications* / Q000188:drug therapy / Q000276:immunology; D006801:Humans; D008297:Male; D012194:RNA-Directed DNA Polymerase / Q000302:isolation & purification
D015483:HIV Antibodies; D016655:HIV Core Protein p24; D005169:Factor VIII; D012194:RNA-Directed DNA Polymerase