[An in vivo experiment on the antitumor action of bleomycin bound to an ion exchange carrier].
Bleomycetin, an antitumor antibiotic of the domestic origin, is component A5 of the bleomycin complex. Design of new drug delivery systems especially for local application is an important problem of antitumor chemotherapy. Bleomycetin immobilized on ion exchange medical gauze was studied with this purpose in an in vivo experimental model of murine lympholeukemia NK/Ly. Subcutaneous implantation of the new dosage form of bleomycetin with prolonged action provided a significant antitumor systemic effect evident from an increase in the mouse life-span. In vitro determination of the bleomycetin contents in the gauze revealed that the antibiotic was completely absorbed from the carrier within 72 hours. The bleomycetin half-life in the plasma after the antibiotic administration in the bound form on the ion exchange gauze was twice as long as that after the antibiotic injection with NaCl isotonic solution.
Tikhomirov
G A
GA
Bukhman
V M
VM
Prigozhina
M M
MM
Filippos'iants
S T
ST
D000818:Animals; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology*; D001761:Bleomycin / Q000737:chemistry / Q000494:pharmacology* / Q000031:analogs & derivatives; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy; D004058:Diffusion; D016503:Drug Delivery Systems; D004343:Drug Implants; D007475:Ion Exchange Resins / Q000737:chemistry*; D007945:Leukemia, Lymphoid / Q000188:drug therapy; D008297:Male; D051379:Mice
D000903:Antibiotics, Antineoplastic; D004343:Drug Implants; D007475:Ion Exchange Resins; D001761:Bleomycin; C025703:bleomycetin