Possible involvement of peripheral-type benzodiazepine receptors in erythroid differentiation of human leukemia cell line, K562.
Possible involvement of the peripheral-type benzodiazepine receptor (PBR) in hemin/protoporphyrin-induced erythroid differentiation of human leukemia K562 cells was investigated by the use of the ligands, diazepam and PK11195. Diazepam itself exhibited differentiation-inducing activity on K562 cells. The PBR-specific antagonist, PK11195, dose-dependently inhibited both diazepam-induced and hemin/protoporphyrin-induced K562 cell differentiation. The results imply that PBR is involved in the erythroid differentiation of K562 cells.
Nakajima
O
O
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Hashimoto
Y
Y
Iwasaki
S
S
D002454:Cell Differentiation / Q000187:drug effects; D002460:Cell Line; D003975:Diazepam / Q000494:pharmacology; D015672:Erythroid Precursor Cells / Q000378:metabolism*; D018757:GABA Modulators / Q000494:pharmacology; D006427:Hemin / Q000494:pharmacology; D006801:Humans; D007546:Isoquinolines / Q000494:pharmacology; D007942:Leukemia, Experimental / Q000378:metabolism*; D011524:Protoporphyrins / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000378:metabolism*
D018757:GABA Modulators; D007546:Isoquinolines; D011524:Protoporphyrins; D011963:Receptors, GABA-A; D006427:Hemin; D003975:Diazepam; C037850:PK 11195