Interactions of HIV-1 envelope glycoproteins with derivatized dextrans.
The present study demonstrates that derivatized dextrans, such as carboxylmethyl dextran benzylamide and carboxymethyl dextran benzylamide sulfonate, specifically interact with HIV-1 envelope glycoproteins (rgp160 and rgp41) with significantly higher affinities than those observed for dextran sulfate (MW 8 kDa). These results suggest the possible involvement in HIV infectivity of surface membrane molecules which may bind the virus at pre or post-CD4 binding steps. They also suggest the possible use of these compounds in anti-HIV therapy.
Carré
V
V
Laboratoire de Biologie Cellulaire, Faculté de Médecine, Université Paris-Nord, Bobigny, France.
Mbemba
E
E
Letourneur
D
D
Jozefonvicz
J
J
Gattegno
L
L
D000595:Amino Acid Sequence; D003911:Dextrans / Q000737:chemistry*; D015686:Gene Products, env / Q000737:chemistry; D019302:HIV Envelope Protein gp160; D015700:HIV Envelope Protein gp41 / Q000737:chemistry*; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000737:chemistry
D003911:Dextrans; D015686:Gene Products, env; D019302:HIV Envelope Protein gp160; D015700:HIV Envelope Protein gp41; D011498:Protein Precursors