title: Esophagopharyngeal distribution of refluxed gastric acid in patients with reflux laryngitis.
abstract: OBJECTIVE
  A variety of otolaryngological abnormalities have been attributed to the contact of gastroesophageal refluxate with respective structures of the aerodigestive tract. The aim of this study was to determine and compare the pharyngoesophageal distribution of gastric acid refluxate between patients with proven laryngitis attributed clinically to gastroesophageal reflux and three control groups.
  
  
  METHODS
  An ambulatory 24-hour simultaneous three-site pharyngoesophageal pH monitoring technique was used to measure reflux parameters in the pharynx, proximal esophagus, and distal esophagus.
  
  
  RESULTS
  Between-group comparison showed no significant difference in the reflux parameters in the distal esophagus between the studied groups. A significantly higher percentage of distal reflux episodes reached the proximal esophagus in the laryngitis group than in the control groups (P < 0.01), and the number of pharyngeal reflux episodes and time of acid exposure were significantly higher in the laryngitis group than in the control groups (P < 0.001).
  
  
  CONCLUSIONS
  Compared with normal controls and patients with gastroesophageal reflux disease, pharyngeal reflux of gastric acid is significantly more prevalent and the ratio of proximal to distal esophageal acid reflux episodes is significantly increased in patients with posterior laryngitis. Simultaneous three-site ambulatory pharyngoesophageal pH monitoring may provide supporting evidence when the diagnosis of reflux-induced aerodigestive tract lesions is considered.
authors.affiliation: Medical College of Wisconsin Dysphagia Institute, Department of Medicine, Milwaukee, USA.
authors.forename: R
authors.initials: R
authors.lastname: Shaker
authors.forename: M
authors.initials: M
authors.lastname: Milbrath
authors.forename: J
authors.initials: J
authors.lastname: Ren
authors.forename: R
authors.initials: R
authors.lastname: Toohill
authors.forename: W J
authors.initials: WJ
authors.lastname: Hogan
authors.forename: Q
authors.initials: Q
authors.lastname: Li
authors.forename: C L
authors.initials: CL
authors.lastname: Hofmann
mesh_terms: D000328:Adult; D004947:Esophagus / Q000378:metabolism*; D005744:Gastric Acid / Q000378:metabolism*; D005764:Gastroesophageal Reflux / Q000150:complications / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007827:Laryngitis / Q000209:etiology / Q000378:metabolism*; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010614:Pharynx / Q000378:metabolism*