Anti-human immunodeficiency virus type 1 activities of U-90152 and U-75875 in human brain cell cultures.
Antiviral activities of the reverse transcriptase inhibitors U-90152 and 3'-azido-2',3'-dideoxythymidine and the protease inhibitor U-75875 were compared in two culture models of human immunodeficiency virus type 1 brain infection. In a model involving acutely infected microglial cells, U-90152 was the most active, whereas in a model using chronically infected promonocytes, U-75875 was the most active.
Peterson
P K
PK
Department of Medicine, Hennepin County Medical Center, Minneapolis, MN 55415.
Gekker
G
G
Hu
S
S
Chao
C C
CC
D000998:Antiviral Agents / Q000494:pharmacology*; D001921:Brain / Q000821:virology*; D002478:Cells, Cultured; D020008:Delavirdine; D017320:HIV Protease Inhibitors / Q000494:pharmacology*; D015497:HIV-1 / Q000187:drug effects*; D006801:Humans; D007211:Indoles / Q000494:pharmacology*; D009842:Oligopeptides / Q000494:pharmacology*; D010879:Piperazines / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis
D000998:Antiviral Agents; D017320:HIV Protease Inhibitors; D007211:Indoles; D009842:Oligopeptides; D010879:Piperazines; D018894:Reverse Transcriptase Inhibitors; D014409:Tumor Necrosis Factor-alpha; C065978:U 75875; D020008:Delavirdine