title: Recognition of viral antigens at the cell surface.
abstract: There is now a very good understanding of the way in which epitope peptides are generated from virus proteins and how the peptides bind to the class I MHC molecules. This gives a framework in which to analyse the potentially protective cytotoxic T lymphocyte response in human immunodeficiency virus infection. A detailed understanding of the specificity of the responding T cells, the clonality of these T cells and the effects of virus variation on the CTL gives a possible explanation for the ultimate failure of the CTL response to control this virus infection.
authors.affiliation: Institute of Molecular Medicine, John Radcliffe Hospital, Oxford.
authors.forename: A
authors.initials: A
authors.lastname: McMichael
authors.forename: P
authors.initials: P
authors.lastname: Klenerman
authors.forename: S
authors.initials: S
authors.lastname: Rowland-Jones
authors.forename: F
authors.initials: F
authors.lastname: Gotch
authors.forename: P
authors.initials: P
authors.lastname: Moss
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000956:Antigens, Viral / Q000378:metabolism*; D000939:Epitopes; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D010455:Peptides / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D000956:Antigens, Viral; D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D010455:Peptides