title: Relationship between lower urinary tract abnormalities and disease-related parameters in multiple sclerosis.
abstract: Multiple sclerosis affects the lower urinary tract in many patients. The relationship between lower urinary tract abnormalities and disease-related parameters of multiple sclerosis is not well described. We screened urologically and neurologically 212 patients according to a standard protocol. Micturition complaints were noted in 52% of the patients and urodynamic abnormalities were found in 64%. A statistical correlation was found between detrusor hyperactivity and detrusor hypoactivity with disease-related parameters, that is disease duration, disability status, myelin basic protein concentration in the cerebrospinal fluid and neurophysiological investigations. No relationship was found between detrusor hypersensibility or detrusor hyposensibility and the aforementioned disease-related parameters. In 1 patient upper urinary tract abnormalities were noted in combination with urodynamic abnormalities. We conclude that lower urinary tract abnormalities can be found in every patient with multiple sclerosis unrelated to the state of the disease. Severe upper urinary tract abnormalities are rare.
authors.affiliation: Department of Urology, University Hospital Nijmegen, The Netherlands.
authors.forename: E L
authors.initials: EL
authors.lastname: Koldewijn
authors.forename: O R
authors.initials: OR
authors.lastname: Hommes
authors.forename: W A
authors.initials: WA
authors.lastname: Lemmens
authors.forename: F M
authors.initials: FM
authors.lastname: Debruyne
authors.forename: P E
authors.initials: PE
authors.lastname: van Kerrebroeck
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001003:Anal Canal / Q000503:physiopathology; D005073:Evoked Potentials, Somatosensory / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid / Q000150:complications* / Q000503:physiopathology; D004676:Myelin Basic Protein / Q000134:cerebrospinal fluid; D011312:Pressure; D011930:Reaction Time; D012018:Reflex / Q000502:physiology; D012727:Sex Characteristics; D014521:Urethra / Q000503:physiopathology; D001743:Urinary Bladder / Q000503:physiopathology; D001745:Urinary Bladder Diseases / Q000150:complications* / Q000503:physiopathology; D014549:Urinary Incontinence / Q000150:complications / Q000503:physiopathology; D014554:Urination; D014555:Urination Disorders / Q000150:complications* / Q000503:physiopathology; D014563:Urodynamics
chemical_list: D004676:Myelin Basic Protein