title: [Yield of ultrasonography-guided transrectal biopsy in the diagnosis of carcinoma of the prostate].
abstract: OBJECTIVE
  The present study analyzes the combination of digital rectal examination (DRE), prostate specific antigen (PSA), transrectal ultrasound (TRUS) and ultrasound-guided transrectal biopsy in the diagnosis of prostate cancer.
  
  
  METHODS
  115 of 224 patients (51.3%) were biopsied due to a suspicious DRE and/or PSA > 4 ng/ml, and/or DPSA > 0.15, and/or the presence of a hypoechoic lesion on TRUS.
  
  
  RESULTS
  Adenocarcinoma of the prostate was diagnosed in 28 (24.3%) of these 115 patients. The positive predictive value (PPV) for carcinoma of the prostate was 4.76% if PSA was < 4 ng/ml, 5.12% if PSA was 4.1 to 10 ng/ml, and 48% if PSA was > 10 ng/ml. If DPSA is considered, the PPV is 7.4% if PSA is 4.1 to 10 ng/ml and 51.02% if PSA is > 10 ng/ml. If DRE is suspicious, the PPV is 43.6%, with a sensitivity of 85.7% and a specificity of 63.9%. The PPV for carcinoma of the prostate was 34% for a hypoechoic lesion on TRUS, 50% if DRE is suspicious, 53.5% is PSA is > 10 ng/ml and 65% if DRE is suspicious and PSA > 10 ng/ml.
  
  
  CONCLUSIONS
  The detection rate of carcinoma of the prostate is increased when DRE, PSA, TRUS and US-guided transrectal biopsy are used in combination.
authors.affiliation: Servicio de Anatomía Patológica, Hospital Universitario de Getafe, Madrid, España.
authors.forename: I
authors.initials: I
authors.lastname: Fernández González
authors.forename: J L
authors.initials: JL
authors.lastname: Ruiz Rubio
authors.forename: C
authors.initials: C
authors.lastname: Llorente Abarca
authors.forename: J A
authors.initials: JA
authors.lastname: Aramburu González
authors.forename: M J
authors.initials: MJ
authors.lastname: Montes Díaz
authors.forename: A
authors.initials: A
authors.lastname: Herrero Payo
authors.forename: E
authors.initials: E
authors.lastname: Sánchez Sánchez
authors.forename: A
authors.initials: A
authors.lastname: Berenguer Sánchez
mesh_terms: D000230:Adenocarcinoma / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D001706:Biopsy / Q000379:methods; D006801:Humans; D008297:Male; D010173:Palpation; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen