Phosphorylethanolamine content of human brain tumors.
Phosphorylethanolamine (PEA) is the major component of the phosphomonoester peak detected by phosphorus-31 magnetic resonance spectroscopy, but the absolute concentration has not been determined. This study measured the PEA concentration in biopsy specimens of brain tumors and lobectomized cerebral cortex using high-performance liquid chromatography. The concentration of PEA was 118.5 +/- 10.0 mumol/100 g wet wt in cortex, and was significantly higher in malignant gliomas, metastatic pulmonary adenocarcinoma, and neurinoma. The concentration of PEA was especially high in pituitary adenoma, malignant lymphoma, and medulloblastoma.
Kinoshita
Y
Y
Department of Neurosurgery, University of Occupational and Environmental Health, Fukuoka.
Yokota
A
A
Koga
Y
Y
D001932:Brain Neoplasms / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D046508:Culture Techniques; D004983:Ethanolamines / Q000032:analysis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy
D004983:Ethanolamines; C005448:phosphorylethanolamine