The effect of beta-aminopropionitrile on bleomycin-induced lung injury in rats.
The effect of beta-aminopropionitrile on collagen cross-links, lysyl oxidase and prolyl hydroxylase and particular collagen type content in rat lungs after bleomycin treatment was investigated. It was stated, that beta-aminopropionitrile significantly diminishes elevated dihydroxylysinonorleucine to hydroxylysinonorleucine ratio, prevented increase of lysyl oxidase activity and increase in type I collagen content in the lungs. It is suggested, that beta-aminopropionitrile may be useful in the treatment of lung fibrosis.
Ledwozyw
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Department of Pathophysiology, Veterinary Faculty, Agricultural Academy, Lublin, Poland.
D000629:Aminopropionitrile / Q000494:pharmacology*; D000818:Animals; D001761:Bleomycin / Q000494:pharmacology; D004151:Dipeptides / Q000378:metabolism; D006900:Hydroxylation / Q000187:drug effects; D008168:Lung / Q000187:drug effects*; D008297:Male; D011393:Procollagen-Proline Dioxygenase / Q000378:metabolism; D008249:Protein-Lysine 6-Oxidase / Q000378:metabolism; D011658:Pulmonary Fibrosis / Q000139:chemically induced* / Q000188:drug therapy / Q000201:enzymology; D051381:Rats; D017207:Rats, Sprague-Dawley
D004151:Dipeptides; D001761:Bleomycin; D000629:Aminopropionitrile; C010991:delta-hydroxylysylnorleucine; D011393:Procollagen-Proline Dioxygenase; C030606:proline, 2-oxoglutarate 3-dioxygenase; D008249:Protein-Lysine 6-Oxidase