Hypertrophic cardiomyopathy associated with tacrolimus in paediatric transplant patients.
Reported side-effects of tacrolimus, a potent immunosuppressive agent, have not included cardiotoxicity. We describe 5 consecutive paediatric transplant recipients (3 small bowel with or without liver and 2 liver) who received tacrolimus. 2 developed congestive heart failure and hypertrophic obstructive cardiomyopathy which resolved after changing to cyclosporin. In the other 3 patients the cardiomyopathy regressed or improved with a lower dose of tacrolimus or after stopping the drug.
Atkison
P
P
Children's Hospital of Western Ontario, University of Western Ontario, London, Canada.
Joubert
G
G
Barron
A
A
Grant
D
D
Paradis
K
K
Seidman
E
E
Wall
W
W
Rosenberg
H
H
Howard
J
J
Williams
S
S
D001794:Blood Pressure / Q000187:drug effects; D002312:Cardiomyopathy, Hypertrophic / Q000139:chemically induced*; D002675:Child, Preschool; D003106:Colon / Q000637:transplantation; D004452:Echocardiography; D005260:Female; D006333:Heart Failure / Q000139:chemically induced; D006801:Humans; D007223:Infant; D016031:Liver Transplantation; D008297:Male; D011183:Postoperative Complications / Q000139:chemically induced*; D016559:Tacrolimus / Q000009:adverse effects* / Q000097:blood
D016559:Tacrolimus