[The effect of diazepam on the activity of carboxypeptidase N and the angiotensin-converting enzyme in sections of the brain of rats with differing normal emotionality and in emotional stress].
Diazepam increased the carboxypeptidase H activity and decreased the angiotensin converting enzyme activity in the rat brain. Joint action of diazepam and emotional stress changed the carboxypeptidase H activity to the least extent and the angiotensin converting enzyme activity to the utmost extent as compared to the agents' separate effects. The role of both enzymes in the diazepam effect is discussed.
Nikishin
N N
NN
Vernigora
A N
AN
Gengin
M T
MT
D000704:Analysis of Variance; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology* / Q000627:therapeutic use; D001921:Brain / Q000187:drug effects* / Q000201:enzymology; D001923:Brain Chemistry / Q000187:drug effects; D002908:Chronic Disease; D003975:Diazepam / Q000494:pharmacology* / Q000627:therapeutic use; D004353:Drug Evaluation, Preclinical; D004644:Emotions / Q000187:drug effects*; D001121:Lysine Carboxypeptidase / Q000032:analysis / Q000187:drug effects*; D008297:Male; D007703:Peptidyl-Dipeptidase A / Q000032:analysis / Q000187:drug effects*; D051381:Rats; D013315:Stress, Psychological / Q000188:drug therapy* / Q000201:enzymology
D014151:Anti-Anxiety Agents; D007703:Peptidyl-Dipeptidase A; D001121:Lysine Carboxypeptidase; D003975:Diazepam