Taxol encapsulation in poly(epsilon-caprolactone) microspheres.
Poly(epsilon-caprolactone) (PCL) microspheres containing taxol were prepared by the solvent evaporation method and tested for angiogenesis inhibition using the chick chorioallantoic membrane (CAM) model. Very high encapsulation efficiencies (95%) for taxol in PCL microspheres were obtained. In vitro release studies showed about 25% of the loaded drug was released in 6 weeks from microspheres containing 5% taxol. Studies with the CAM showed that taxol released from the microspheres induced vascular regression and inhibited angiogenesis.
Dordunoo
S K
SK
Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
Jackson
J K
JK
Arsenault
L A
LA
Oktaba
A M
AM
Hunter
W L
WL
Burt
H M
HM
D000482:Allantois / Q000098:blood supply; D000818:Animals; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply; D003692:Delayed-Action Preparations; D008863:Microspheres; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D017239:Paclitaxel / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D011091:Polyesters
D003692:Delayed-Action Preparations; D011091:Polyesters; C016240:polycaprolactone; D017239:Paclitaxel