title: Use of complementary peptides and their antibodies in T-cell-mediated autoimmune disease: experiments with myelin basic protein.
abstract: In this article we review the field of idiotype (Id) network and experimental allergic encephalomyelitis, focusing on the generation of monoclonal antibody anti-Id by using complementary peptide and the investigation of anti-Id immunoregulatory effects on immune responses of B and T cells to specific myelin basic protein peptides in vitro and in vivo.
authors.affiliation: Department of Neurology, University of Alabama at Birmingham 35294.
authors.forename: S R
authors.initials: SR
authors.lastname: Zhou
authors.forename: J N
authors.initials: JN
authors.lastname: Whitaker
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D000911:Antibodies, Monoclonal / Q000276:immunology; D001327:Autoimmune Diseases / Q000276:immunology* / Q000517:prevention & control; D001483:Base Sequence; D007130:Immunoglobulin Idiotypes / Q000276:immunology*; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000276:immunology*; D010455:Peptides / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D000888:Antibodies, Anti-Idiotypic; D000911:Antibodies, Monoclonal; D007130:Immunoglobulin Idiotypes; D004676:Myelin Basic Protein; D010455:Peptides