The international standard for macrophage colony stimulating factor (M-CSF). Evaluation in an international collaborative study.
Three ampouled preparations of macrophage colony stimulating factor (M-CSF) were evaluated by 23 laboratories in nine countries for their suitability to serve as international standards for this material. The preparations were assayed in a wide range of in vitro bioassays and immunoassays. On the basis of results reported here, with the agreement of the participants in the study and with the authorization of the Expert Committee on Biological Standardization (ECBS) of the World Health Organization (WHO), the preparation in ampoules coded 89/512 was established as the international standard for M-CSF.
Mire-Sluis
A R
AR
Division of Immunobiology and Informatics Laboratory, National Institute for Biological Standards and Control, Herts, UK.
Das
R G
RG
Thorpe
R
R
D000818:Animals; D001681:Biological Assay; D001854:Bone Marrow Cells; D016466:CHO Cells; D002460:Cell Line; D006224:Cricetinae; D004305:Dose-Response Relationship, Drug; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology; D006801:Humans; D007118:Immunoassay; D016173:Macrophage Colony-Stimulating Factor / Q000592:standards* / Q000652:urine; D011994:Recombinant Proteins
D011994:Recombinant Proteins; D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor