[Mucin-associated antigens as markers of gastrointestinal differentiation and carcinogenesis].
Mucins are heavily glycosylated glycoproteins which exhibit a variety of antigenic determinants consisting of carbohydrates and/or peptide sequences. The application of monoclonal antibodies and lectins in immunohistochemistry resulted in a considerable extension of knowledge regarding their topography during histogenesis. Additionally, typical alterations of antigenic profiles during neoplastic transformation of cells and tissues were described. A number of new results are in keeping with the assumption that mucin-associated antigens play an important role in tumor biology, for example metastasis, and as markers of prognosis. The purpose of the present paper is to give a review, including the authors' own results, of knowledge on the gastro-intestinal mucin antigens in experimental and clinical pathology.
Baldus
S E
SE
Institut für Pathologie, Universität zu Köln.
Hanisch
F G
FG
D000818:Animals; D000951:Antigens, Neoplasm / Q000032:analysis*; D014408:Biomarkers, Tumor / Q000032:analysis; D002471:Cell Transformation, Neoplastic / Q000473:pathology*; D015179:Colorectal Neoplasms / Q000473:pathology; D000939:Epitopes / Q000032:analysis*; D005753:Gastric Mucosa / Q000473:pathology; D005770:Gastrointestinal Neoplasms / Q000473:pathology*; D006801:Humans; D007413:Intestinal Mucosa / Q000473:pathology; D009077:Mucins / Q000032:analysis*; D011230:Precancerous Conditions / Q000473:pathology; D013274:Stomach Neoplasms / Q000473:pathology
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D000939:Epitopes; D009077:Mucins