[Physiopathology of BPH obstruction].
The underlying BPH related mechanisms of outlet obstruction are outlined (modification of the shape of the bladder neck, failure of funnel formation, geometric variations of the urethra, alpha 1 adrenoceptors mediated sympathetic hyperactivity at the level of the lower genito-urinary tract). Bladder voiding dysfunction in response to prostate obstruction is also discussed and correlated to ultrastructural patterns and clinical symptoms. Finally, a pathogenetic mechanism for detrusor overactivity in obstructed bladder is suggested.
Zaroli
A
A
U.O. di Urologia, U.S.S.L. n. 8, Busto Arsizio.
Mandressi
A
A
Belloni
M
M
Antonelli
D
D
Bernasconi
S
S
Buizza
C
C
Chisena
S
S
D006801:Humans; D008297:Male; D008954:Models, Biological; D011470:Prostatic Hyperplasia / Q000473:pathology / Q000503:physiopathology*; D001743:Urinary Bladder / Q000503:physiopathology / Q000648:ultrastructure