Evolution of H3N8 equine influenza virus from 1963 to 1991.
The antigenic properties of H3N8 influenza viruses isolated from outbreaks of equine influenza in Sweden between 1979 and 1991 have been studied in hemagglutination inhibition tests with polyclonal and monoclonal antisera, and antigenic drift of the virus has been demonstrated. To clarify the basis of the antigenic drift, amino acid sequences of the globular head regions (HA1) of the hemagglutinin membrane glycoproteins of virus strains from 1979, 1984, 1988 and 1990 have been deduced from the nucleotide sequences of the hemagglutinin genes, and the sequence information has been used to construct a phylogenetic tree of H3N8 equine influenza strains. Several strains from previous studies have been included to give a clearer picture of viral evolution in an international context.
Oxburgh
L
L
Department of Veterinary Microbiology, Swedish University of Agricultural Sciences, Uppsala.
Berg
M
M
Klingeborn
B
B
Emmoth
E
E
Linné
T
T
D000595:Amino Acid Sequence; D000818:Animals; D000906:Antibodies; D000911:Antibodies, Monoclonal; D001483:Base Sequence; D005075:Biological Evolution; D005787:Gene Frequency; D006385:Hemagglutination Inhibition Tests; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral / Q000235:genetics*; D006734:Horse Diseases / Q000821:virology*; D006736:Horses; D053123:Influenza A Virus, H3N8 Subtype; D009980:Influenza A virus / Q000235:genetics* / Q000302:isolation & purification; D008969:Molecular Sequence Data; D009976:Orthomyxoviridae Infections / Q000662:veterinary* / Q000821:virology; D012367:RNA, Viral / Q000302:isolation & purification; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013548:Sweden; D013997:Time Factors; D014759:Viral Envelope Proteins / Q000235:genetics
D000906:Antibodies; D000911:Antibodies, Monoclonal; D019267:Hemagglutinin Glycoproteins, Influenza Virus; D006389:Hemagglutinins, Viral; D012367:RNA, Viral; D014759:Viral Envelope Proteins