title: Susceptibility in cell culture of feline immunodeficiency virus to eighteen antiviral agents.
abstract: The in-vitro susceptibilities of two strains of feline immunodeficiency virus to 18 antiviral agents were determined in two cell lines. In terms of inhibiting p24 antigen production, the nucleoside-analogue reverse transcriptase inhibitors were the most effective compounds. Inhibition was also observed with aurintricarboxylic acid, phosphonoformate and butyldeoxynorjirimycin, but not with the other agents tested.
authors.affiliation: Department of Veterinary Clinical Science and Animal Husbandry, University of Liverpool, UK.
authors.forename: N R
authors.initials: NR
authors.lastname: Smyth
authors.forename: C
authors.initials: C
authors.lastname: McCracken
authors.forename: R M
authors.initials: RM
authors.lastname: Gaskell
authors.forename: J M
authors.initials: JM
authors.lastname: Cameron
authors.forename: J A
authors.initials: JA
authors.lastname: Coates
authors.forename: C J
authors.initials: CJ
authors.lastname: Gaskell
authors.forename: C A
authors.initials: CA
authors.lastname: Hart
authors.forename: M
authors.initials: M
authors.lastname: Bennett
mesh_terms: D000818:Animals; D000956:Antigens, Viral / Q000096:biosynthesis; D000998:Antiviral Agents / Q000494:pharmacology* / Q000633:toxicity; D002415:Cats; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000821:virology; D008826:Microbial Sensitivity Tests; D018894:Reverse Transcriptase Inhibitors
chemical_list: D000956:Antigens, Viral; D000998:Antiviral Agents; D018894:Reverse Transcriptase Inhibitors