title: Scratching the surface with the PH domain.
abstract: Pleckstrin homology (PH) domains bind to membrane surfaces, and inositol phospholipids appear to form part of the binding sites. Recent structural studies provide a model for PH domain anchoring to inositol phospholipids that will open new avenues for functional investigation.
authors.forename: K M
authors.initials: KM
authors.lastname: Ferguson
authors.forename: M A
authors.initials: MA
authors.lastname: Lemmon
authors.forename: P B
authors.initials: PB
authors.lastname: Sigler
authors.forename: J
authors.initials: J
authors.lastname: Schlessinger
mesh_terms: D000818:Animals; D001665:Binding Sites; D001798:Blood Proteins / Q000737:chemistry* / Q000378:metabolism; D006801:Humans; D007295:Inositol Phosphates / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry* / Q000378:metabolism*; D051379:Mice; D008956:Models, Chemical; D010750:Phosphoproteins; D017510:Protein Folding; D017386:Sequence Homology, Amino Acid
chemical_list: D001798:Blood Proteins; D007295:Inositol Phosphates; D008565:Membrane Proteins; D010750:Phosphoproteins; C039077:platelet protein P47