Comparative study on the levels of alpha-fetoprotein (AFP) in different pathological cases.
The research represents a trial to demonstrate the changes which probably took place in AFP levels as a tumor marker among pregnant egyptian women suffering from bilharzial and cancerous infestations. It was found that combination of schistosomal infection with pregnancy leads to obvious high significant increase in AFP in late pregnancy (6-8 months) compared to unpregnant patients. Although the combination between bilharzial infestation and early pregnancy leads to increase in AFP level, the differences were non significant compared to unpregnant ones. There is an extremely significant increase in AFP levels among urinary and intestinal schistosomal pregnant patients compared with healthy pregnant women which was higher in intestinal infection and more pronounced in early pregnancy than late ones. Malignancy in combination with pregnancy caused markable greatly significant increase compared to unpregnant patients, and the increases were slightly higher in bladder than colonic cancerous cases and their AFP levels were gradually increased with progress of both pregnancy and malignancy. In combination of malignancy with pregnant schistosomal infested women to study the effect of schistosomal infection the detected increase in AFP was statistically non significant at early pregnancy and malignancy, turned to significancy at late ones either in bladder or colonic cases.
Ahmed
S A
SA
Department of Medical Chemistry, National Research Centre, Dokki, Cairo, Egypt.
Bahgat
M M
MM
D000293:Adolescent; D000328:Adult; D003110:Colonic Neoplasms / Q000097:blood / Q000150:complications; D005260:Female; D006801:Humans; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic / Q000097:blood*; D015597:Pregnancy Complications, Parasitic / Q000097:blood*; D012552:Schistosomiasis / Q000097:blood* / Q000150:complications; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000150:complications; D000509:alpha-Fetoproteins / Q000032:analysis*
D000509:alpha-Fetoproteins