Colchicine toxicity--clinical features and treatment. Massive overdose case report.
This is a report of colchicine poisoning in a 24-year-old woman. She developed multiple organ failure and bone marrow suppression after the suicidal ingestion of 50 (1 mg) colchicine tablets. The pancytopenia responded to granulocyte colony-stimulating factor 300 micrograms on days 4, 5, 6, and 8. Although anticolchicine monoclonal antibody administration is the only specific therapy described, intensive supportive care including granulocyte colony-stimulating factor administration can facilitate recovery from severe colchicine intoxication.
Folpini
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A
Department of Anaesthesia, Intensive Care and Pain Therapy, Ospedale Regionale, Massa, Italy.
Furfori
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P
D000328:Adult; D001772:Blood Cell Count; D003078:Colchicine / Q000097:blood / Q000506:poisoning*; D062787:Drug Overdose; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D008111:Liver Function Tests; D009102:Multiple Organ Failure / Q000139:chemically induced* / Q000503:physiopathology / Q000628:therapy*; D013406:Suicide, Attempted
D016179:Granulocyte Colony-Stimulating Factor; D003078:Colchicine