title: Novel approaches to linkage mapping.
abstract: The recent progress seen in the development of high-quality genetic markers and high-density human genetic maps is facilitating new strategies for mapping disease-causing and disease-susceptibility genes. These strategies, which include homozygosity mapping, DNA pooling, and the utilization of linkage disequilibrium, have been successfully applied to the mapping and fine mapping of several loci causing diseases segregating in genetically isolated populations.
authors.affiliation: Department of Pediatrics, University of Iowa, Iowa City 52242, USA.
authors.forename: V C
authors.initials: VC
authors.lastname: Sheffield
authors.forename: D Y
authors.initials: DY
authors.lastname: Nishimura
authors.forename: E M
authors.initials: EM
authors.lastname: Stone
mesh_terms: D002874:Chromosome Mapping / Q000379:methods*; D004247:DNA / Q000032:analysis; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000235:genetics; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D010375:Pedigree
chemical_list: D005819:Genetic Markers; D004247:DNA