Effect of ibuprofen on the acute-phase response and protein metabolism in patients with cancer and weight loss.
The aim of this study was to determine whether administration of the non-steroidal anti-inflammatory agent ibuprofen might attenuate the acute-phase response in patients with colonic cancer. Cytokines and acute-phase proteins were measured before administration of ibuprofen and again 3 days later, when protein synthesis was measured using 15N-glycine. In patients with cancer, ibuprofen caused a significant reduction in the plasma concentration of all five acute-phase proteins studied. Although interleukin 6 levels were raised, they did not change following administration of ibuprofen. Unlike the situation in patients with cancer who did not receive ibuprofen, whole-body protein kinetics were similar to those of control subjects in patients with cancer who received ibuprofen. Whether or not ibuprofen had been administered, non-export hepatic protein synthesis rates were significantly lower in patients with than in those without cancer. These results suggest that short-term administration of ibuprofen can attenuate accelerated whole-body protein kinetics and the acute-phase response in patients with advanced cancer.
Preston
T
T
Isotope Biochemistry Laboratory, Scottish Universities Research and Reactor Centre, Glasgow, UK.
Fearon
K C
KC
McMillan
D C
DC
Winstanley
F P
FP
Slater
C
C
Shenkin
A
A
Carter
D C
DC
D000209:Acute-Phase Proteins / Q000378:metabolism; D000210:Acute-Phase Reaction / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism*; D003110:Colonic Neoplasms / Q000150:complications* / Q000378:metabolism; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000627:therapeutic use*; D007375:Interleukin-1 / Q000378:metabolism; D015850:Interleukin-6 / Q000378:metabolism; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism; D015431:Weight Loss
D000209:Acute-Phase Proteins; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D002097:C-Reactive Protein; D007052:Ibuprofen