Usefulness of granulocyte colony-stimulating factor on neutropenia in patients of invasive mole and choriocarcinoma.
The effect of human granulocyte colony stimulating factor (hG-CSF) was investigated on the proliferation of choriocarcinoma cells in vitro. No growth-stimulating effect was observed. Then, 22 patients with invasive mole and 9 patients with choriocarcinoma who received combination chemotherapy were treated with hG-CSF when white blood cell counts decreased below 2,000/mm3. The duration of neutropenia was reduced significantly by 3-4 days with the use of hG-CSF. No side effects were observed. These results indicate safety and usefulness of hG-CSF as an adjunct to chemotherapy in the treatment of gestational trophoblastic disease.
Okamoto
T
T
Department of Obstetrics and Gynecology, Nagoya University School of Medicine, Japan.
Nawa
A
A
Nakanishi
T
T
Kato
N
N
Ino
K
K
Suzuki
T
T
Goto
S
S
Tomoda
Y
Y
D000328:Adult; D000970:Antineoplastic Agents / Q000009:adverse effects / Q000627:therapeutic use; D002455:Cell Division / Q000187:drug effects; D002822:Choriocarcinoma / Q000097:blood / Q000188:drug therapy*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D002820:Hydatidiform Mole, Invasive / Q000097:blood / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control*; D011247:Pregnancy; D012189:Retrospective Studies; D014407:Tumor Cells, Cultured; D014594:Uterine Neoplasms / Q000097:blood / Q000188:drug therapy*
D000970:Antineoplastic Agents; D016179:Granulocyte Colony-Stimulating Factor