title: Transformation of congenital neutropenia into monosomy 7 and acute nonlymphoblastic leukemia in a child treated with granulocyte colony-stimulating factor.
abstract: A cytogenetically normal infant with Kostmann syndrome (severe congenital granulocytopenia) was treated with granulocyte colony-stimulating factor, which resulted in a rapid improvement in his neutrophil count and a resolution of recurrent infections. After 11 months of therapy, splenomegaly developed, with thrombocytopenia, anemia, circulating nucleated erythrocytes, and acquired monosomy 7, which evolved during a period of 7 months into acute nonlymphoblastic leukemia. The use of granulocyte colony-stimulating factor in patients with congenital marrow failure disorders may induce or hasten the onset of a malignant transformation.
authors.affiliation: Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.
authors.forename: M E
authors.initials: ME
authors.lastname: Weinblatt
authors.forename: P
authors.initials: P
authors.lastname: Scimeca
authors.forename: A
authors.initials: A
authors.lastname: James-Herry
authors.forename: I
authors.initials: I
authors.lastname: Sahdev
authors.forename: J
authors.initials: J
authors.lastname: Kochen
mesh_terms: D002897:Chromosomes, Human, Pair 7 / Q000187:drug effects*; D002908:Chronic Disease; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D009006:Monosomy / Q000175:diagnosis*; D009503:Neutropenia / Q000150:complications / Q000151:congenital* / Q000628:therapy; D013997:Time Factors
chemical_list: D016179:Granulocyte Colony-Stimulating Factor