title: A phase II study of paclitaxel and granulocyte colony-stimulating factor in previously untreated patients with extensive-stage small cell lung cancer: a study of the North Central Cancer Treatment Group.
abstract: In 1994, approximately 34,000 to 43,000 Americans will be diagnosed with small cell lung cancer, and 60% to 70% of these individuals will have extensive-stage disease. The median survival time of patients with extensive-stage small cell lung cancer is 8 to 10 months and 10% or less will survive 2 years. There have been no major advances in the treatment of this stage of disease in the past decade. Phase II trials with promising new single-agent chemotherapeutic drugs are justifiable. We report the design and toxicity of a phase II trial with single-agent paclitaxel (Taxol; Bristol-Myers Squibb Company, Princeton, NJ) in previously untreated patients with extensive-stage small cell lung cancer.
authors.affiliation: Pittsburgh Cancer Institute, PA 15213, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Jett
authors.forename: R J
authors.initials: RJ
authors.lastname: Kirschling
authors.forename: S H
authors.initials: SH
authors.lastname: Jung
authors.forename: R S
authors.initials: RS
authors.lastname: Marks
mesh_terms: D018288:Carcinoma, Small Cell / Q000188:drug therapy*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D017239:Paclitaxel / Q000009:adverse effects / Q000627:therapeutic use*; D012074:Remission Induction
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D017239:Paclitaxel