Carcinogenic effects of cytostatic protocols in CBA/Ca mice.
An in vivo mouse model was developed in order to study the characteristics of secondary tumor induction by cytostatic drug combinations used in human anticancer treatment. In this model we have proved the carcino-leukemogenic effects of widely used chemotherapeutical drug combinations (CHOP, COPP, COPBLAM, VAM). The carcinogenic hazards of cyclophosphamide and other alkylating drugs could also be demonstrated in our model.
Ember
I
I
Department of Public Health, University Medical School of Pecs, Hungary.
Raposa
T
T
Varga
C
C
Herceg
L
L
Kiss
I
I
D000818:Animals; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects; D001761:Bleomycin / Q000009:adverse effects; D003520:Cyclophosphamide / Q000009:adverse effects; D003606:Dacarbazine / Q000009:adverse effects; D004195:Disease Models, Animal; D004317:Doxorubicin / Q000009:adverse effects; D005260:Female; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA / Q000502:physiology*; D016685:Mitomycin / Q000009:adverse effects; D009374:Neoplasms, Experimental / Q000139:chemically induced*; D011241:Prednisone / Q000009:adverse effects; D011344:Procarbazine / Q000009:adverse effects; D014747:Vinblastine; D014750:Vincristine / Q000009:adverse effects
D001761:Bleomycin; D011344:Procarbazine; D016685:Mitomycin; D014750:Vincristine; D014747:Vinblastine; D003606:Dacarbazine; D004317:Doxorubicin; D003520:Cyclophosphamide; D011241:Prednisone