Evidence that double transfection to xenoendothelial cells using GPI-anchoring complement regulatory factor (decay-accelerating factor and homologous restriction factor 20) gene is useful for the inhibition of human complement-mediated cytolysis.
Hayashi
S
S
Department of Surgery II, Nagoya University School of Medicine, Japan.
Isobe
K
K
Emi
N
N
Okada
H
H
Yasutomi
M
M
Negita
M
M
Koike
C
C
Uchida
K
K
Yokoyama
I
I
Takagi
H
H
D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000502:physiology*; D001011:Aorta; D001798:Blood Proteins / Q000096:biosynthesis / Q000502:physiology*; D018958:CD55 Antigens; D018957:CD59 Antigens; D002352:Carrier Proteins / Q000096:biosynthesis / Q000502:physiology*; D002417:Cattle; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D003169:Complement Inactivator Proteins / Q000096:biosynthesis / Q000502:physiology*; D003165:Complement System Proteins / Q000633:toxicity*; D004730:Endothelium, Vascular / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D005796:Genes; D017261:Glycosylphosphatidylinositols / Q000096:biosynthesis; D006801:Humans; D008562:Membrane Glycoproteins / Q000096:biosynthesis / Q000502:physiology*; D014162:Transfection; D014183:Transplantation, Heterologous
D015703:Antigens, CD; D001798:Blood Proteins; D018958:CD55 Antigens; D018957:CD59 Antigens; D002352:Carrier Proteins; D003169:Complement Inactivator Proteins; D017261:Glycosylphosphatidylinositols; D008562:Membrane Glycoproteins; C051590:CD59 protein, human; D003165:Complement System Proteins