Activation-induced death of mature T cells in the regulation of immune responses.
Deletion of self-reactive clones of immature thymocytes by activation-induced death (AID) is thought to be the primary mechanism for the establishment of self-tolerance in the T-cell compartment. Recent evidence suggests that a genetically distinct but analogous process of AID in mature T cells is important in regulating peripheral immune responses. AID of peripheral T cells requires the expression of functional Fas and Fas ligand by the T-cell population. As qualitatively similar signals from the TCR are responsible for both T-cell expansion in inflammation and T-cell elimination by AID, regulating the balance between these opposing functions plays a crucial role in successful responses to pathogens and tumors while minimizing autoimmunity.
Russell
J H
JH
Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA.
D000818:Animals; D017951:Antigen Presentation / Q000276:immunology / Q000502:physiology; D017209:Apoptosis; D018106:CD28 Antigens / Q000276:immunology / Q000502:physiology; D016207:Cytokines / Q000276:immunology / Q000502:physiology; D003602:Cytotoxicity, Immunologic; D008024:Ligands; D008213:Lymphocyte Activation; D051379:Mice; D008815:Mice, Inbred Strains; D018448:Models, Immunological; D013601:T-Lymphocytes / Q000276:immunology* / Q000502:physiology; D018417:Th1 Cells / Q000276:immunology / Q000502:physiology; D019014:fas Receptor / Q000276:immunology / Q000502:physiology
D018106:CD28 Antigens; D016207:Cytokines; D008024:Ligands; D019014:fas Receptor