title: Cytotoxicity of captafol in mammalian cells.
abstract: The cytotoxicity of captafol, a phthalimide-derived fungicide, was evaluated in IB-RS-2 cells. Captafol at 0.12-1.0 microgram/ml blocks the cell multiplication. This effect is concentration-dependent, only partially reversible and the degree of inhibition increases with time. The synthesis of DNA and RNA is inhibited in parallel by increasing concentrations of the chemical.
authors.affiliation: Instituto Biológico, São Paulo, Brazil.
authors.forename: M A
authors.initials: MA
authors.lastname: Rodrigues
authors.forename: M
authors.initials: M
authors.lastname: D'Angelo
mesh_terms: D000818:Animals; D002215:Captan / Q000031:analogs & derivatives* / Q000633:toxicity; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D053138:Cyclohexenes; D004261:DNA Replication / Q000187:drug effects; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D012313:RNA / Q000096:biosynthesis; D013552:Swine
chemical_list: D053138:Cyclohexenes; D012313:RNA; C001614:captafol; D002215:Captan