[Scleroderma of the shoulders after treatment with combined bleomycin and radiotherapy].
BACKGROUND
There are many causes of scleroderma. We observed a case of scleroderma involving the shoulder and neck area after combined bleomycin and radiotherapy.


METHODS
After six cycles of a CHOP-bleo protocol followed by radiotherapy for lymph node lymphoma, a female patient presented scleroderma involving the shoulders and neck area. Total bleomycin dose was 252 mg.


CONCLUSIONS
Among the imputable factors, particularly extrinsic factors, in a series of 33 cases of different chemotherapy protocols published by Peters et al. in 1988, we retained the bleomycin radiotherapy administration sequence as the cause of this complication. Given after bleomycin, radiotherapy could increase the risk of scleroderma.
Marck
Y
Y
Service de Dermatologie-Allergologie-Photobiologie, Hôpital St-Charles, Montpellier.
Meunier
L
L
Barnéon
G
G
Meynadier
J
J
D000328:Adult; D001761:Bleomycin / Q000008:administration & dosage / Q000009:adverse effects*; D003131:Combined Modality Therapy; D003680:Deglutition Disorders / Q000209:etiology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000628:therapy; D009333:Neck; D011855:Radiodermatitis / Q000175:diagnosis; D011878:Radiotherapy / Q000009:adverse effects*; D011879:Radiotherapy Dosage; D012594:Scleroderma, Localized / Q000150:complications / Q000209:etiology* / Q000473:pathology
D001761:Bleomycin