[Biochemistry, molecular mechanism of action and biological effects of endotoxin].
This review is a brief attempt at providing an overview of a subject of enormous complexity-endotoxins and the mediators associated with its biological effects. More specifically it deals with biochemistry and biology of endotoxin, detection of endotoxin with the Limulus amebocyte lysate test, the molecular mechanisms and biological effects, and in the last part with future aspects of therapeutical strategies. It seems certain that the subject will become even more complex and possibly controversial as scientific knowledge further involves. However, because of the high mortality rate of patients suffering from gram-negative sepsis all efforts have to be made to find effective therapeutical strategies.
Burgmann
H
H
Abteilung für Infektionen, Universitätsklinik für Innere Medizin I, Wien.
Breyer
S
S
D000818:Animals; D015703:Antigens, CD / Q000276:immunology; D015214:Antigens, Differentiation, Myelomonocytic / Q000276:immunology; D016470:Bacteremia / Q000276:immunology*; D016207:Cytokines / Q000502:physiology; D004731:Endotoxins / Q000276:immunology*; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides / Q000276:immunology; D008262:Macrophage Activation / Q000276:immunology; D009102:Multiple Organ Failure / Q000276:immunology / Q000628:therapy; D012772:Shock, Septic / Q000276:immunology* / Q000628:therapy
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D016207:Cytokines; D004731:Endotoxins; D018950:Lipopolysaccharide Receptors; D008070:Lipopolysaccharides