title: The induction of respiratory syncytial virus-specific cytotoxic T-cell responses following immunization with a synthetic peptide containing a fusion peptide linked to a cytotoxic T lymphocyte epitope.
abstract: Previously published work has shown that a cytotoxic T-cell epitope (CTL) representing residues 82-90 of the M2 protein of respiratory syncytial virus (RSV) is the target for a protective response against the virus. In this report, we demonstrate that a synthetic peptide representing residues 81-95, when covalently linked to a fusion peptide derived from the conserved N-terminal 19 residues of the F1 protein of measles virus efficiently primes RSV-specific CTLs in vivo following immunization without adjuvant.
authors.affiliation: Department of Clinical Sciences, London School of Hygiene & Tropical Medicine, UK.
authors.forename: S C
authors.initials: SC
authors.lastname: Hsu
authors.forename: D M
authors.initials: DM
authors.lastname: Shaw
authors.forename: M W
authors.initials: MW
authors.lastname: Steward
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D000956:Antigens, Viral / Q000276:immunology*; D003602:Cytotoxicity, Immunologic; D007114:Immunization; D051379:Mice; D008807:Mice, Inbred BALB C; D008815:Mice, Inbred Strains; D008969:Molecular Sequence Data; D010446:Peptide Fragments / Q000276:immunology*; D018113:Respiratory Syncytial Virus, Human / Q000276:immunology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*; D014760:Viral Fusion Proteins / Q000276:immunology
chemical_list: D000956:Antigens, Viral; D010446:Peptide Fragments; D014760:Viral Fusion Proteins