Do autoantibodies to IgE play a role in IgE-mediated events?
Elevated blood levels of IgG anti-IgE are detectable in individuals exhibiting enhanced IgE production, namely those with allergic conditions and helminthic parasite infections. The fact that there are epitope-specific subpopulations of autoanti-IgE suggests that this autoantibody could potentially have multiple effects in immunological events involving IgE.
Shakib
F
F
Department of Immunology, Medical School, Queen's Medical Centre, Nottingham, UK.
Smith
S J
SJ
Pritchard
D I
DI
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D001249:Asthma / Q000276:immunology; D001323:Autoantibodies / Q000276:immunology*; D000939:Epitopes; D006373:Helminthiasis / Q000276:immunology; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology; D007105:Immune Complex Diseases / Q000276:immunology; D007073:Immunoglobulin E / Q000096:biosynthesis / Q000276:immunology*; D007074:Immunoglobulin G / Q000276:immunology*; D051381:Rats
D000888:Antibodies, Anti-Idiotypic; D001323:Autoantibodies; D000939:Epitopes; D007074:Immunoglobulin G; D007073:Immunoglobulin E