Recognition of viral antigens at the cell surface.
There is now a very good understanding of the way in which epitope peptides are generated from virus proteins and how the peptides bind to the class I MHC molecules. This gives a framework in which to analyse the potentially protective cytotoxic T lymphocyte response in human immunodeficiency virus infection. A detailed understanding of the specificity of the responding T cells, the clonality of these T cells and the effects of virus variation on the CTL gives a possible explanation for the ultimate failure of the CTL response to control this virus infection.
McMichael
A
A
Institute of Molecular Medicine, John Radcliffe Hospital, Oxford.
Klenerman
P
P
Rowland-Jones
S
S
Gotch
F
F
Moss
P
P
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000956:Antigens, Viral / Q000378:metabolism*; D000939:Epitopes; D015395:Histocompatibility Antigens Class I / Q000378:metabolism*; D006801:Humans; D010455:Peptides / Q000378:metabolism; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000956:Antigens, Viral; D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D010455:Peptides