Transformation of congenital neutropenia into monosomy 7 and acute nonlymphoblastic leukemia in a child treated with granulocyte colony-stimulating factor.
A cytogenetically normal infant with Kostmann syndrome (severe congenital granulocytopenia) was treated with granulocyte colony-stimulating factor, which resulted in a rapid improvement in his neutrophil count and a resolution of recurrent infections. After 11 months of therapy, splenomegaly developed, with thrombocytopenia, anemia, circulating nucleated erythrocytes, and acquired monosomy 7, which evolved during a period of 7 months into acute nonlymphoblastic leukemia. The use of granulocyte colony-stimulating factor in patients with congenital marrow failure disorders may induce or hasten the onset of a malignant transformation.
Weinblatt
M E
ME
Department of Pediatrics, North Shore University Hospital-Cornell University Medical College, Manhasset, New York 11030.
Scimeca
P
P
James-Herry
A
A
Sahdev
I
I
Kochen
J
J
D002897:Chromosomes, Human, Pair 7 / Q000187:drug effects*; D002908:Chronic Disease; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007223:Infant; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis / Q000209:etiology*; D008297:Male; D009006:Monosomy / Q000175:diagnosis*; D009503:Neutropenia / Q000150:complications / Q000151:congenital* / Q000628:therapy; D013997:Time Factors
D016179:Granulocyte Colony-Stimulating Factor