[Monoclonal antibodies to the HNK-1 antigen of human natural killers].
The ability of monoclonal antibodies (MAb) to HNK1 antigen of natural killers (NK), previously purified by affinity chromatography, to react with human blood lymphocytes has been studied by flow cytometry. The results obtained point to some cells, among blood lymphocytes, which have antigenic determinants to these MAbs. A decrease in the NK cell cytotoxic activity was shown after addition of MAb in comparison with the control. This enables us to suggest a reactivity of these MABs to the CD57 leucocyte differential antigens.
Atochina
O V
OV
Aksenova
N N
NN
Neustroev
A P
AP
Ivanov
V A
VA
D000818:Animals; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000276:immunology* / Q000302:isolation & purification; D015703:Antigens, CD / Q000276:immunology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000276:immunology*; D018959:CD57 Antigens; D002846:Chromatography, Affinity; D003601:Cytotoxicity Tests, Immunologic; D004797:Enzyme-Linked Immunosorbent Assay; D005434:Flow Cytometry; D005455:Fluorescent Antibody Technique; D006801:Humans; D006825:Hybridomas / Q000276:immunology; D007075:Immunoglobulin M / Q000302:isolation & purification; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C
D000911:Antibodies, Monoclonal; D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D018959:CD57 Antigens; D007075:Immunoglobulin M