title: The molecular basis of fragile sites in human chromosomes.
abstract: Fragile sites on chromosomes have been classified into a number of groups according to their frequency and the conditions required to induce them. A number of the rare folate-sensitive fragile sites have been characterized and shown to be amplified methylated CCG trinucleotide repeats. One common fragile site has been partly characterized and appears to be a region of fragility, rather than a single site.
authors.affiliation: Department of Cytogenetics and Molecular Genetics, Women's and Children's Hospital, Adelaide, Australia.
authors.forename: G R
authors.initials: GR
authors.lastname: Sutherland
authors.forename: R I
authors.initials: RI
authors.lastname: Richards
mesh_terms: D016590:Aphidicolin / Q000494:pharmacology; D043283:Chromosome Fragile Sites; D002873:Chromosome Fragility; D002877:Chromosomes, Human / Q000737:chemistry / Q000235:genetics*; D046508:Culture Techniques / Q000379:methods; D005786:Gene Expression Regulation; D005796:Genes; D006801:Humans; D009154:Mutation; D012091:Repetitive Sequences, Nucleic Acid; D017422:Sequence Analysis, DNA
chemical_list: D016590:Aphidicolin