title: T helper cell differentiation in immune response.
abstract: Significant progress has been made in understanding the maturation of antigen-specific CD4+ T helper cell responses. Recent progress centers on the network of cytokines, accessory molecules, and cell types that shapes the differentiation of distinct T helper cell subsets. Use of transgenic and knockout mice and well characterized in vivo models have helped clarify the interdependence or independence of many of these complex factors.
authors.affiliation: Gwenn Knapp Center for Lupus and Immunology Research, Department of Medicine, University of Chicago, IL 60637-5420, USA.
authors.forename: S L
authors.initials: SL
authors.lastname: Reiner
authors.forename: R A
authors.initials: RA
authors.lastname: Seder
mesh_terms: D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D016207:Cytokines / Q000276:immunology; D015870:Gene Expression; D007371:Interferon-gamma / Q000276:immunology; D007376:Interleukin-2 / Q000276:immunology; D008213:Lymphocyte Activation / Q000235:genetics; D051379:Mice; D008807:Mice, Inbred BALB C; D018345:Mice, Knockout; D008822:Mice, Transgenic; D018448:Models, Immunological; D011110:Polymorphism, Genetic; D015398:Signal Transduction; D006377:T-Lymphocytes, Helper-Inducer / Q000166:cytology / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology
chemical_list: D016207:Cytokines; D007376:Interleukin-2; D007371:Interferon-gamma