title: Antimalarial sesquiterpenes from tubers of Cyperus rotundus: structure of 10,12-peroxycalamenene, a sesquiterpene endoperoxide.
abstract: Activity-guided investigation of Cyperus rotundus tubers led to the isolation of patchoulenone, caryophyllene alpha-oxide, 10,12-peroxycalamenene and 4,7-dimethyl-1-tetralone. The antimalarial activities of these compounds are in the range of EC50 10(-4)-10(-6) M, with the novel endoperoxide sesquiterpene, 10,12-peroxycalamenene, exhibiting the strongest effect at EC50 2.33 x 10(-6) M.
authors.affiliation: National Science and Technology Development Agency, Bangkok, Thailand.
authors.forename: C
authors.initials: C
authors.lastname: Thebtaranonth
authors.forename: Y
authors.initials: Y
authors.lastname: Thebtaranonth
authors.forename: S
authors.initials: S
authors.lastname: Wanauppathamkul
authors.forename: Y
authors.initials: Y
authors.lastname: Yuthavong
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009904:Optical Rotation; D018517:Plant Roots; D010946:Plants, Medicinal; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000633:toxicity
chemical_list: C096076:10,12-peroxycalamenene; D000962:Antimalarials; D012717:Sesquiterpenes