Neurotransmitters and cytokines in CNS pathology.
In summary, we have demonstrated an in vitro model for oligodendrocyte cell death that may be relevant to events in formation of lesions in MS. It involves cell contact to oligodendrocytes with activated, viable microglia (or inflammatory macrophages), surface TNF-alpha, surface adhesion molecules, and production of NO. Precise mechanisms of TNF-alpha and ICAM-1/LFA-1 participation and the nature of the susceptibility of the oligodendrocyte are currently being studied.
Mitrovic
B
B
UCLA School of Medicine 90024.
Martin
F C
FC
Charles
A C
AC
Ignarro
L J
LJ
Anton
P A
PA
Shanahan
F
F
Merrill
J E
JE
D015526:AIDS Dementia Complex / Q000378:metabolism; D000818:Animals; D001253:Astrocytes / Q000378:metabolism; D002118:Calcium / Q000502:physiology; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology; D016923:Cell Death; D002478:Cells, Cultured; D016207:Cytokines / Q000096:biosynthesis / Q000235:genetics; D003711:Demyelinating Diseases; D005786:Gene Expression Regulation; D008264:Macrophages / Q000378:metabolism; D009103:Multiple Sclerosis / Q000378:metabolism* / Q000473:pathology; D015213:Neuroimmunomodulation; D009569:Nitric Oxide / Q000502:physiology* / Q000633:toxicity; D009836:Oligodendroglia / Q000473:pathology*; D051381:Rats; D018040:Receptors, Neurokinin-1 / Q000502:physiology*; D013373:Substance P / Q000502:physiology
D015816:Cell Adhesion Molecules, Neuronal; D016207:Cytokines; D018040:Receptors, Neurokinin-1; D009569:Nitric Oxide; D013373:Substance P; D002118:Calcium