Effect of lindane on galactose and leucine transport in chicken enterocytes.
Lindane (gamma-hexachlorocyclohexane) influence on the in vitro intestinal transport of D-galactose and L-leucine has been studied in isolated chicken enterocytes. Animals were injected i.p. with 30 mg/kg b.w. of the pesticide over 7 days. Total uptake of D-galactose and L-leucine was significantly decreased by lindane action. There was no alteration in the non-mediated component, but the mediated transport was markedly inhibited in both cases. Furthermore, the exit of D-galactose across the basolateral membrane, as well as (Na(+)-K+)-ATPase activity, was significantly decreased in pesticide-treated chickens.
Moreno
M J
MJ
Department of Physiology and Nutrition, Faculty of Pharmacy, University of Navarra, Pamplona, Spain.
Pellicer
S
S
Marti
A
A
Arenas
J C
JC
Fernández-Otero
M P
MP
D000818:Animals; D001692:Biological Transport; D002645:Chickens; D005690:Galactose / Q000378:metabolism*; D001556:Hexachlorocyclohexane / Q000494:pharmacology*; D066298:In Vitro Techniques; D007583:Jejunum / Q000166:cytology / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D007930:Leucine / Q000378:metabolism*; D008297:Male; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism
D001556:Hexachlorocyclohexane; D000254:Sodium-Potassium-Exchanging ATPase; D007930:Leucine; D005690:Galactose