title: Alteration of Wilms' tumor staging by cytologic detection of malignant cells in chylous ascites.
abstract: Accurate staging as per National Wilms' Tumor Study (NWTS) criteria is essential for therapy of Wilms' tumor. We report a unique case of a 9-mo-old white male in whom the diagnosis based upon clinical, radiological, surgical, and initial histopathologic findings was Stage I Wilms' tumor without regard to a positive cytologic examination of a small amount (5 ml) of chylous ascitic fluid obtained intraoperatively. This problem was clarified later at the NWTS panel review when the deeper recuts of a renal hilar lymph node revealed a single cluster of Wilms' tumor cells in capsular sinus, resulting in upstaging of tumor to Stage III. The significance of these findings in relation to staging will be discussed.
authors.affiliation: Department of Pathology, University of Mississippi Medical Center, Jackson 39216, USA.
authors.forename: M
authors.initials: M
authors.lastname: Baliga
authors.forename: N
authors.initials: N
authors.lastname: Holmquist
authors.forename: R P
authors.initials: RP
authors.lastname: Warrier
mesh_terms: D002913:Chyle / Q000166:cytology*; D002915:Chylous Ascites / Q000473:pathology*; D006801:Humans; D007223:Infant; D007680:Kidney Neoplasms / Q000473:pathology*; D008297:Male; D009367:Neoplasm Staging; D013194:Staining and Labeling; D009396:Wilms Tumor / Q000473:pathology*