The major acute phase serum protein in pigs is homologous to human plasma kallikrein sensitive PK-120.
A major acute phase protein (pig-MAP) has been isolated from the sera of pigs after turpentine injection. The protein is the pig counterpart of a recently cloned human serum protein denominated PK-120, which is a putative substrate for kallikrein [Nishimura et al., 1995 FEBS Lett. 357, 207-211]. The protein exists in other mammalian species and it is also an acute phase protein, at least in the rat. Pig-MAP shows homology, as PK-120, with the heavy chain 2 (HC-2) of the inter-alpha-trypsin inhibitor superfamily but does not possess trypsin inhibitory activity.
González-Ramón
N
N
Departamento de Bioquímica y Biología Molecular y Celular, Facultad de Ciencias, Universidad de Zaragoza, Spain.
Alava
M A
MA
Sarsa
J A
JA
Piñeiro
M
M
Escartin
A
A
Garcia-Gil
A
A
Lampreave
F
F
Piñeiro
A
A
D000209:Acute-Phase Proteins / Q000032:analysis* / Q000737:chemistry; D000595:Amino Acid Sequence; D000818:Animals; D001798:Blood Proteins / Q000737:chemistry*; D002417:Cattle; D006023:Glycoproteins / Q000737:chemistry*; D006801:Humans; D007610:Kallikreins / Q000494:pharmacology; D008297:Male; D008969:Molecular Sequence Data; D053491:Proteinase Inhibitory Proteins, Secretory; D051381:Rats; D017208:Rats, Wistar; D017386:Sequence Homology, Amino Acid; D012756:Sheep; D013552:Swine / Q000097:blood*; D014357:Trypsin / Q000378:metabolism; D014425:Turpentine
D000209:Acute-Phase Proteins; D001798:Blood Proteins; D006023:Glycoproteins; D007610:Kallikreins; D053491:Proteinase Inhibitory Proteins, Secretory; D014357:Trypsin; D014425:Turpentine; C091236:ITIH4 protein, human; C095815:ITIH4 protein, Sus scrofa