title: Interleukin-11.
abstract: Interleukin-11 (IL-11), a stromal cell-derived cytokine, has been known to act widely in hematopoietic and non-hematopoietic systems. IL-11 supports the growth of certain types of plasmacytoma and hybridoma cells, acts with interleukin-3 (IL-3) in shortening the Go period of early progenitors. IL-11 supports megakaryocyte colony formation and maturation, and acts as an autocrine growth factor in megakaryoblastic cell lines. In addition, IL-11 stimulates erythrocytopoiesis, enhances antigen-specific antibody responses, induces the synthesis of acute phase proteins, inhibits lipoprotein lipase activity and adipocyte differentiation, and promotes neuronal development. Administration of rhIL-11 to mice resulted in an increase of neutrophils and platelets. The human IL-11 gene is localized at 19q13.3-13.4, and codes 199 amino acids and 23 kDa with no N glycosylation. Its receptor and signal transduction share partially those of interleukin-6 (IL-6). Further analysis of its role in normal and pathological state is necessary to determine the exact function and its application for clinical uses.
authors.affiliation: Department of Hematology, Tokyo Women's Medical College, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kobayashi
authors.forename: M
authors.initials: M
authors.lastname: Teramura
authors.forename: K
authors.initials: K
authors.lastname: Oshimi
authors.forename: H
authors.initials: H
authors.lastname: Mizoguchi
mesh_terms: D000209:Acute-Phase Proteins / Q000096:biosynthesis; D000273:Adipose Tissue / Q000187:drug effects; D000818:Animals; D002888:Chromosomes, Human, Pair 19; D015672:Erythroid Precursor Cells / Q000187:drug effects; D005796:Genes; D006412:Hematopoietic Stem Cells / Q000187:drug effects / Q000502:physiology; D006801:Humans; D017370:Interleukin-11 / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D053703:Interleukin-11 Receptor alpha Subunit; D008214:Lymphocytes / Q000187:drug effects; D008533:Megakaryocytes / Q000187:drug effects; D051379:Mice; D009474:Neurons / Q000187:drug effects; D018123:Receptors, Interleukin / Q000502:physiology; D053702:Receptors, Interleukin-11; D015398:Signal Transduction
chemical_list: D000209:Acute-Phase Proteins; C508428:IL11RA protein, human; C508429:Il11ra1 protein, mouse; D017370:Interleukin-11; D053703:Interleukin-11 Receptor alpha Subunit; D018123:Receptors, Interleukin; D053702:Receptors, Interleukin-11