Altered reactivity of human cerebral arteries after subarachnoid hemorrhage.
To investigate the effects of subarachnoid hemorrhage (SAH) on the responsiveness of human cerebral arteries to vasoactive substances, the authors measured the isometric tension generated in helical strips of basilar and middle cerebral arteries isolated from human cadavers. Contractions caused by KCl, prostaglandin F2 alpha, noradrenaline, and serotonin were reduced in arteries obtained from cadavers with aneurysmal SAH damage and compared to those obtained from cadavers with no indication of intracranial diseases. Endothelium-dependent relaxation elicited by substance P and bradykinin, and endothelium-independent relaxation induced by prostaglandin I2 and nitroglycerin were also markedly decreased in arteries affected by SAH. However, the reduction in relaxation response to prostaglandin I2 was significantly less than that to the other vasodilator agents. These results indicate that human cerebral artery functions are severely impaired after SAH and that poor responses to vasoactive agents may result primarily from dysfunction of smooth-muscle cells.
Onoue
H
H
Department of Neurosurgery, Jikei University School of Medicine, Tokyo, Japan.
Kaito
N
N
Akiyama
M
M
Tomii
M
M
Tokudome
S
S
Abe
T
T
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D001920:Bradykinin / Q000494:pharmacology; D002536:Cerebral Arteries / Q000187:drug effects / Q000503:physiopathology*; D015237:Dinoprost / Q000494:pharmacology; D011464:Epoprostenol / Q000494:pharmacology; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D007537:Isometric Contraction / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000503:physiopathology; D005996:Nitroglycerin / Q000494:pharmacology; D009638:Norepinephrine / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D013345:Subarachnoid Hemorrhage / Q000150:complications*; D013373:Substance P / Q000494:pharmacology
D012701:Serotonin; D013373:Substance P; D015237:Dinoprost; D011464:Epoprostenol; D005996:Nitroglycerin; D001920:Bradykinin; D009638:Norepinephrine