Thalidomide-resistant HIV-associated aphthae successfully treated with granulocyte colony-stimulating factor.
Thalidomide has been advocated as the treatment of choice for recalcitrant aphthae. We describe the case of patient with HIV infection and extensive aphthae whose condition failed to respond to corticosteroids, cyclosporine, and thalidomide. The patient's course was complicated by colonic aphthae. Rapid and sustained resolution was achieved through treatment with granulocyte colony-stimulating factor, a previously unreported therapeutic option.
Manders
S M
SM
Department of Medicine, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, USA.
Kostman
J R
JR
Mendez
L
L
Russin
V L
VL
D000328:Adult; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D015658:HIV Infections / Q000150:complications*; D006801:Humans; D013281:Stomatitis, Aphthous / Q000188:drug therapy* / Q000821:virology; D013792:Thalidomide / Q000627:therapeutic use*
D016179:Granulocyte Colony-Stimulating Factor; D013792:Thalidomide