Lymphopoiesis. Transcription factors controlling B-cell development.
Two structurally dissimilar transcriptional regulators, E2A and Pax-5, have been shown to play essential roles in B-cell development; the p50 subunit of NF kappa B, by contrast, is required for normal immune responses.
Desiderio
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Department of Molecular Biology and Genetics, Howard Hughes Medical Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins / Q000235:genetics / Q000502:physiology*; D018507:Gene Expression Regulation, Developmental; D018257:Helix-Loop-Helix Motifs / Q000502:physiology; D006410:Hematopoiesis / Q000235:genetics / Q000502:physiology*; D007153:Immunologic Deficiency Syndromes / Q000235:genetics; D051379:Mice; D018345:Mice, Knockout; D008822:Mice, Transgenic; D005810:Multigene Family; D016328:NF-kappa B / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins / Q000235:genetics / Q000502:physiology*; D051757:PAX5 Transcription Factor; D051820:TCF Transcription Factors; D015534:Trans-Activators / Q000235:genetics / Q000502:physiology*; D000073940:Transcription Factor 4; D058125:Transcription Factor 7-Like 1 Protein; D014157:Transcription Factors
D051778:Basic Helix-Loop-Helix Leucine Zipper Transcription Factors; D004268:DNA-Binding Proteins; D016328:NF-kappa B; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D051757:PAX5 Transcription Factor; C497282:Pax5 protein, mouse; D051820:TCF Transcription Factors; C090743:Tcf4 protein, mouse; C544913:Tcf7l1 protein, mouse; D015534:Trans-Activators; D000073940:Transcription Factor 4; D058125:Transcription Factor 7-Like 1 Protein; D014157:Transcription Factors