title: [Male with sudden-onset dementia associated with long lasting diarrhea as manifestations of Whipple's disease].
abstract: A case of a 55-year old male with Whipple's disease who consulted for dementia (aggressivity, memory loss of recent events, sleep rhythm disturbances) is presented. Furthermore, the patient had referred changes in intestinal movement four years beforehand in addition to erratic arthralgias. Response to treatment (trimethoprim-sulfamethoxazole for one year) was favorable with resolution of both the neurologic and gastrointestinal pictures. The radiologic alterations of this entity are reviewed and suggest that this disease should be considered as a cause of dementia.
authors.affiliation: Servicio de Medicina Interna, Hospital Provincial (Complejo Hospitalario Universitario Infanta Cristina), Badajoz.
authors.forename: A
authors.initials: A
authors.lastname: Ortiz Cansado
authors.forename: L
authors.initials: L
authors.lastname: Márquez Velázquez
authors.forename: E
authors.initials: E
authors.lastname: Maciá Botejara
authors.forename: A
authors.initials: A
authors.lastname: Marin Antúnez
authors.forename: R
authors.initials: R
authors.lastname: Cordero Torres
authors.forename: M
authors.initials: M
authors.lastname: Solana Lara
authors.forename: J
authors.initials: J
authors.lastname: Sáenz de Santamaría
mesh_terms: D000900:Anti-Bacterial Agents / Q000008:administration & dosage; D003704:Dementia / Q000209:etiology*; D003967:Diarrhea / Q000209:etiology*; D004724:Endoscopy; D006801:Humans; D008297:Male; D008875:Middle Aged; D010402:Penicillin G Procaine / Q000008:administration & dosage; D010406:Penicillins / Q000008:administration & dosage; D013307:Streptomycin / Q000008:administration & dosage; D013997:Time Factors; D014057:Tomography, X-Ray Computed; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000008:administration & dosage; D008061:Whipple Disease / Q000150:complications / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents; D010406:Penicillins; D010402:Penicillin G Procaine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination; D013307:Streptomycin