Origin and specification of type II sensory neurons in Drosophila.
The peripheral nervous system (PNS) of Drosophila is a preferred model for studying the genetic basis of neurogenesis because its simple and stereotyped pattern makes it ideal for mutant analysis. Type I sensory organs, the external (bristle-type) sensory organs (es) and the internal (stretch-receptive) chordotonal organs (ch), have been postulated to derive from individual ectodermal precursor cells that undergo a stereotyped pattern of cell division. Little is known about the origin and specification of type II sensory neurons, the multiple dendritic (md) neurons. Using the flp/FRT recombinase system from yeast, we have determined that a subset of md neurons derives from es organ lineages, another subset derives from ch organ lineages and a third subset is unrelated to sensory organs. We also provide evidence that the genes, numb and cut, are both required for the proper differentiation of md neurons.
Brewster
R
R
Department of Biology, University of Michigan, Ann Arbor 48109-1048, USA.
Bodmer
R
R
D000818:Animals; D002454:Cell Differentiation / Q000235:genetics; D004330:Drosophila / Q000196:embryology* / Q000235:genetics; D029721:Drosophila Proteins; D017344:Genes, Insect; D005821:Genetic Techniques; D018398:Homeodomain Proteins; D007301:Insect Hormones / Q000235:genetics*; D007605:Juvenile Hormones / Q000235:genetics; D009024:Morphogenesis / Q000235:genetics; D009154:Mutation; D009419:Nerve Tissue Proteins / Q000235:genetics; D009475:Neurons, Afferent; D009687:Nuclear Proteins / Q000235:genetics; D017933:Peripheral Nervous System / Q000166:cytology / Q000196:embryology*; D010641:Phenotype; D014157:Transcription Factors
D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D007301:Insect Hormones; D007605:Juvenile Hormones; D009419:Nerve Tissue Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; C066381:ct protein, Drosophila; C060606:numb protein, Drosophila