Inhibition of gp120-CD4 interaction and human immunodeficiency virus type 1 infection in vitro by pyridoxal 5'-phosphate.
Pyridoxal 5'-phosphate and related compounds were tested for their ability to inhibit gp120-CD4 interaction and human immunodeficiency virus infection in vitro. The results show that pyridoxal 5'-phosphate is a unique CD4 antagonist whose antiviral potency derives from the presence of both lysine-reactive and anionic substituents.
Guo
L
L
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha 68198-5120.
Heinzinger
N K
NK
Stevenson
M
M
Schopfer
L M
LM
Salhany
J M
JM
D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid / Q000494:pharmacology; D015496:CD4-Positive T-Lymphocytes / Q000378:metabolism*; D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis; D015699:HIV Envelope Protein gp120 / Q000378:metabolism*; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000187:drug effects*; D011732:Pyridoxal Phosphate / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors; D014779:Virus Replication / Q000187:drug effects
D015699:HIV Envelope Protein gp120; D018894:Reverse Transcriptase Inhibitors; D011732:Pyridoxal Phosphate; D004247:DNA; D054303:HIV Reverse Transcriptase; D017878:4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid