Intracellular signalling. PI 3-kinase puts GTP on the Rac.
Phosphoinositide 3-kinase, an enzyme that is known to transduce signals received by a variety of receptor types, has been found to mediate agonist-dependent membrane ruffling via the small GTP-binding protein Rac.
Parker
P J
PJ
Imperial Cancer Research Fund, London, UK.
D000595:Amino Acid Sequence; D000730:Androstadienes / Q000494:pharmacology; D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure*; D019204:GTP-Binding Proteins / Q000502:physiology*; D006160:Guanosine Triphosphate / Q000502:physiology*; D008954:Models, Biological; D008969:Molecular Sequence Data; D005810:Multigene Family; D019869:Phosphatidylinositol 3-Kinases; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D010766:Phosphorylation; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000502:physiology*; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D017479:Receptors, Platelet-Derived Growth Factor / Q000187:drug effects; D015398:Signal Transduction / Q000187:drug effects / Q000502:physiology*; D000077191:Wortmannin; D020744:rac GTP-Binding Proteins
D000730:Androstadienes; D018129:Phosphatidylinositol Phosphates; D010716:Phosphatidylinositols; D010982:Platelet-Derived Growth Factor; D006160:Guanosine Triphosphate; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D017479:Receptors, Platelet-Derived Growth Factor; D019204:GTP-Binding Proteins; D020744:rac GTP-Binding Proteins; D000077191:Wortmannin