title: Sclerosing B-cell lymphoma involving the skin.
abstract: We report a case of sclerosing B-cell lymphoma involving the skin. The patient is a 43-year-old man who came to our institution with a 4-year history of multinodular masses in the back. A thoracic CT scan demonstrated subcutaneous masses with extension to the posterior parietal pleura and compression of several epidural spaces. An incisional biopsy was performed and demonstrated an infiltrative process in the lower dermis composed of interconnected thick sclerosing bands forming compartments around groups of large neoplastic cells. These neoplastic cells were shown to be B lymphocytes using immunohistochemical stains. A diagnosis of diffuse sclerosing B-cell lymphoma, large cell type, was made. Our case is reported to alert dermatologists and dermatopathologists to the occurrence of this neoplasm in the skin which could be confused with a deep inflammatory process or other neoplastic conditions.
authors.affiliation: Department of Pathology, Ohio State University Medical Center, Columbus 43210.
authors.forename: J C
authors.initials: JC
authors.lastname: Cruz-Ramon
authors.forename: T P
authors.initials: TP
authors.lastname: Blodgett
authors.forename: D L
authors.initials: DL
authors.lastname: Puthuff
authors.forename: J K
authors.initials: JK
authors.lastname: Wilkin
authors.forename: A E
authors.initials: AE
authors.lastname: Pellegrini
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D006801:Humans; D007633:Keratins / Q000032:analysis; D016393:Lymphoma, B-Cell / Q000737:chemistry / Q000473:pathology*; D008297:Male; D009418:S100 Proteins / Q000032:analysis; D012598:Sclerosis / Q000473:pathology; D012878:Skin Neoplasms / Q000737:chemistry / Q000473:pathology*
chemical_list: D015703:Antigens, CD; D009418:S100 Proteins; D007633:Keratins