Contribution of B cell subsets to delayed development of MAIDS in xid mice.
C57BL/6 (B6) mice develop a syndrome of progressive lymphoproliferation and immunodeficiency, murine AIDS (MAIDS), when infected with an etiologic replication-defective virus termed BM5def. Induction of MAIDS requires the presence of CD4+ T cells and B cells. B6 mice with altered conventional B cell function and a deficit in CD5+ B cells due to the xid mutation develop disease with a greatly prolonged latency. The association of this mutation with resistance to MAIDS was confirmed in studies of P.xid mice. To test the hypothesis that conventional B cells are required for rapid induction of disease, B6.xid mice were injected with spleen cells from nude mice or were given bone marrow from aged donors. Both sets of recipients developed advanced disease by 10 weeks post infection, suggesting that resistance to MAIDS in xid mutants may be due to effects of B cells other than the CD5+ subset.
Tang
Y
Y
Laboratory of Immunopathology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20892, USA.
Kim
W K
WK
Holmes
K L
KL
Hügin
A W
AW
Kenny
J J
JJ
Chattopadhyay
S K
SK
Hartley
J W
JW
Morse
H C
HC
D000077329:Agammaglobulinaemia Tyrosine Kinase; D000818:Animals; D015703:Antigens, CD / Q000235:genetics; D016175:B-Lymphocyte Subsets / Q000276:immunology* / Q000637:transplantation*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D018956:CD5 Antigens; D005434:Flow Cytometry; D007153:Immunologic Deficiency Syndromes / Q000235:genetics; D051379:Mice; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D008822:Mice, Transgenic; D016183:Murine Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology*; D009154:Mutation / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000235:genetics; D014960:X Chromosome / Q000235:genetics
D015703:Antigens, CD; D018956:CD5 Antigens; D011505:Protein-Tyrosine Kinases; D000077329:Agammaglobulinaemia Tyrosine Kinase; C000625951:Btk protein, mouse