The use of felbamate in patients with periodic lateralized epileptiform discharges (PLEDs).
This case report refers to a patient with PLEDs whose EEGs did not change while on steady levels of phenytoin and phenobarbital, but showed a complete disappearance of these discharges when felbamate was used. This report may serve to remind EEG'ers and epileptologists that the acute use of this drug may be effective in dealing with PLEDs that are often difficult to eliminate. However, physicians must keep in mind the significant risks of using this medication.
Hughes
J R
JR
University of Illinois Medical Center, Chicago 60612, USA.
Fuller
T
T
D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D004292:Dominance, Cerebral / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004359:Drug Therapy, Combination; D004569:Electroencephalography / Q000187:drug effects*; D017036:Epilepsia Partialis Continua / Q000188:drug therapy*; D000078328:Felbamate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010634:Phenobarbital / Q000009:adverse effects / Q000627:therapeutic use; D048448:Phenylcarbamates; D010672:Phenytoin / Q000009:adverse effects / Q000627:therapeutic use; D011409:Propylene Glycols / Q000009:adverse effects / Q000627:therapeutic use*; D013226:Status Epilepticus / Q000188:drug therapy*
D000927:Anticonvulsants; D048448:Phenylcarbamates; D011409:Propylene Glycols; D010672:Phenytoin; D000078328:Felbamate; D010634:Phenobarbital