Kuehneromycins A and B, two new biological active compounds from a Tasmanian Kuehneromyces sp. (Strophariaceae, Basidiomycetes).
In a search for new inhibitors of RNA-directed DNA-polymerases kuehneromycin A (1) was isolated from fermentations of a Tasmanian Kuehneromyces species. Its structure was elucidated by spectroscopic methods. Kuehneromycin A (1) is a non-competitive inhibitor of avian myeloblastosis virus (Ki 200 microM) and moloney murine leukemia virus (Ki 40 microM) reverse transcriptases. The second compound, kuehneromycin B (2) is a strong inhibitor of platelet aggregation stimulated with different inducers. In addition, both compounds exhibit cytotoxic and antimicrobial activities.
Erkel
G
G
Lehrbereich Biotechnologie der Universität, Bundesrepublik, Deutschland.
Lorenzen
K
K
Anke
T
T
Velten
R
R
Gimenez
A
A
Steglich
W
W
D016475:3T3 Cells; D000447:Aldehydes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009189:Avian Myeloblastosis Virus / Q000201:enzymology; D001419:Bacteria / Q000187:drug effects; D001487:Basidiomycota / Q000737:chemistry* / Q000254:growth & development; D001572:Benzofurans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002286:Carcinoma, Ehrlich Tumor; D002470:Cell Survival / Q000187:drug effects; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000201:enzymology; D007700:Kinetics; D007939:Leukemia L1210; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D008980:Moloney murine sarcoma virus / Q000201:enzymology; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification*; D018894:Reverse Transcriptase Inhibitors; D013648:Tasmania; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000447:Aldehydes; D000900:Anti-Bacterial Agents; D001572:Benzofurans; D010975:Platelet Aggregation Inhibitors; D018894:Reverse Transcriptase Inhibitors; D013764:Tetrahydronaphthalenes; C092912:kuehneromycin A; C086704:panudial; D054303:HIV Reverse Transcriptase