Mouse NK1+ T cells.
Mouse NK1+ T cells constitute a special subset of alpha beta TCR+ T cells that express natural killer surface receptors and are thought to play an immunoregulatory role because of their unique ability to secrete IL-4 within minutes of primary activation. The recent discovery that they recognize non-polymorphic MHC class I like ligands encoded by CD1 family genes sheds a new light on unusual aspects of their development as well as on some of the possible ways in which they might influence the regulation of the T-helper cell (types 1 and 2) classes of immune responses.
Bendelac
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Department of Molecular Biology, Princeton University, New Jersey 08544, USA.
D000595:Amino Acid Sequence; D000818:Animals; D018949:Antigens, CD1 / Q000276:immunology; D001483:Base Sequence; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D000939:Epitopes; D015395:Histocompatibility Antigens Class I / Q000276:immunology; D007694:Killer Cells, Natural / Q000276:immunology* / Q000502:physiology; D008213:Lymphocyte Activation; D051379:Mice / Q000276:immunology*; D008815:Mice, Inbred Strains; D018345:Mice, Knockout; D008819:Mice, Nude; D008822:Mice, Transgenic; D018448:Models, Immunological; D008969:Molecular Sequence Data; D010641:Phenotype; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics / Q000276:immunology; D013154:Spleen / Q000276:immunology; D016176:T-Lymphocyte Subsets / Q000276:immunology* / Q000502:physiology; D013950:Thymus Gland / Q000276:immunology
D018949:Antigens, CD1; D000939:Epitopes; D015395:Histocompatibility Antigens Class I; D016693:Receptors, Antigen, T-Cell, alpha-beta