Evaluation of some arylhydrazones of p-aminobenzoic acid hydrazide as antimicrobial agents and their in vitro hepatic microsomal metabolism.
Benzoic acid p-amino-[(substituted phenyl/pyridyl) methylene] hydrazide derivatives were synthesised by interaction of p-aminobenzoic acid hydrazide with various aromatic aldehydes. The structures of the compounds were elucidated by use of their UV, IR, 1H-NMR and mass spectral data. These compounds were also evaluated for antimicrobial activity. The in vitro hepatic microsomal metabolism of benzoic acid p-amino-[(4-fluorophenyl)methylene]hydrazide (2d), a selected prototype from these compounds was also carried out.
Komurcu
S G
SG
University of Marmara, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, Haydarpasa, Istanbul, Turkey.
Rollas
S
S
Ulgen
M
M
Gorrod
J W
JW
Cevikbas
A
A
D000818:Animals; D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis* / Q000378:metabolism / Q000494:pharmacology*; D066298:In Vitro Techniques; D008297:Male; D008826:Microbial Sensitivity Tests; D008862:Microsomes, Liver / Q000378:metabolism*; D051381:Rats
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D006835:Hydrazones