Neonates treated with ECMO: predictive value of early CT and US neuroimaging findings on short-term neurodevelopmental outcome.
OBJECTIVE
To determine if neuroimaging findings in infants who undergo extracorporeal membrane oxygenation (ECMO) are predictive of developmental outcome.


METHODS
At 1-2 years of age, 183 ECMO survivors (69 female, 114 male) underwent developmental examination. Neuroimaging studies obtained at time of ECMO were assigned a neuroimaging score. Neuroimaging findings were correlated with developmental outcome.


RESULTS
Eighty-five infants had neuroimaging abnormalities. Development was normal in 105 infants, suspect in 37, and delayed in 41. Mean neuroimaging scores were significantly worse in survivors with delayed development (P < or = .0001). The sensitivity and specificity of normal neuroimaging findings in prediction of normal outcome were 65% and 63%, respectively. Survivors with nonhemorrhagic abnormalities had a higher risk of delayed development than did those with isolated hemorrhagic abnormalities (39% vs 21%).


CONCLUSIONS
Although they cannot be used alone to predict outcome, early neuroimaging scores can be used to assign risk categories for developmental outcome.
Bulas
D I
DI
Department of Diagnostic Imaging and Radiology, Children's National Medical Center, Washington, DC 20010, USA.
Glass
P
P
O'Donnell
R M
RM
Taylor
G A
GA
Short
B L
BL
Vezina
G L
GL
D001921:Brain / Q000000981:diagnostic imaging*; D001927:Brain Diseases / Q000000981:diagnostic imaging* / Q000453:epidemiology; D002543:Cerebral Hemorrhage / Q000000981:diagnostic imaging* / Q000453:epidemiology; D002675:Child, Preschool; D002658:Developmental Disabilities / Q000453:epidemiology*; D004453:Echoencephalography; D015199:Extracorporeal Membrane Oxygenation; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D016015:Logistic Models; D008297:Male; D011237:Predictive Value of Tests; D012307:Risk Factors; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed