title: The importance of extended conformations and, in particular, the PII conformation for the molecular recognition of peptides.
abstract: Crystallographic, isotopic labeling nmr and transferred nuclear Overhauser effect studies have highlighted the extended conformation as a very important element of secondary structure at the binding site of many peptide/protein complexes including peptide inhibitors-enzymes, B-cell epitopes-antibodies, and T-cell epitopes-major histocompatibility complex (MHC) of class I and II complexes. This paper discusses the peptide ligand conformation consequences of these findings particularly in view of the identification of the PII conformation (left-handed extended polyproline II) in free solution.
authors.affiliation: Department of Chemistry, Birkbeck College, University of London, United Kingdom.
authors.forename: G
authors.initials: G
authors.lastname: Siligardi
authors.forename: A F
authors.initials: AF
authors.lastname: Drake
mesh_terms: D000595:Amino Acid Sequence; D000936:Antigen-Antibody Complex / Q000737:chemistry; D001665:Binding Sites; D002942:Circular Dichroism; D004247:DNA / Q000737:chemistry / Q000378:metabolism; D000939:Epitopes / Q000737:chemistry / Q000276:immunology; D008024:Ligands; D008969:Molecular Sequence Data; D011480:Protease Inhibitors / Q000737:chemistry / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D017433:Protein Structure, Secondary
chemical_list: D000936:Antigen-Antibody Complex; D000939:Epitopes; D008024:Ligands; D011480:Protease Inhibitors; D004247:DNA