title: Taxol encapsulation in poly(epsilon-caprolactone) microspheres.
abstract: Poly(epsilon-caprolactone) (PCL) microspheres containing taxol were prepared by the solvent evaporation method and tested for angiogenesis inhibition using the chick chorioallantoic membrane (CAM) model. Very high encapsulation efficiencies (95%) for taxol in PCL microspheres were obtained. In vitro release studies showed about 25% of the loaded drug was released in 6 weeks from microspheres containing 5% taxol. Studies with the CAM showed that taxol released from the microspheres induced vascular regression and inhibited angiogenesis.
authors.affiliation: Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, Canada.
authors.forename: S K
authors.initials: SK
authors.lastname: Dordunoo
authors.forename: J K
authors.initials: JK
authors.lastname: Jackson
authors.forename: L A
authors.initials: LA
authors.lastname: Arsenault
authors.forename: A M
authors.initials: AM
authors.lastname: Oktaba
authors.forename: W L
authors.initials: WL
authors.lastname: Hunter
authors.forename: H M
authors.initials: HM
authors.lastname: Burt
mesh_terms: D000482:Allantois / Q000098:blood supply; D000818:Animals; D002642:Chick Embryo; D002823:Chorion / Q000098:blood supply; D003692:Delayed-Action Preparations; D008863:Microspheres; D009389:Neovascularization, Pathologic / Q000517:prevention & control; D017239:Paclitaxel / Q000008:administration & dosage* / Q000493:pharmacokinetics / Q000494:pharmacology; D011091:Polyesters
chemical_list: D003692:Delayed-Action Preparations; D011091:Polyesters; C016240:polycaprolactone; D017239:Paclitaxel