Substance P modulating effect on the binding capacity of hamster Leydig cell LH receptors.
The influence of Substance P was studied on the binding characteristics of LH receptors in purified Leydig cells collected from golden hamsters kept under natural long or short days. Substance P exerted a differential effect on the binding capacity of LH receptors. A significant increase in Bmax was estimated in Leydig cells obtained from young hamsters living under long days. In contrast, Substance P reduced the number of the LH binding sites in Leydig cell cultures prepared from adult hamsters housed under short-day conditions.
Kanchev
L N
LN
Institute of Biology and Immunology of Reproduction, Bulgarian Academy of Sciences, Sofia.
Konakchieva
R
R
Angelova
P A
PA
Davidoff
M S
MS
D000818:Animals; D002478:Cells, Cultured; D006224:Cricetinae; D007985:Leydig Cells / Q000187:drug effects* / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism; D008297:Male; D008647:Mesocricetus; D011974:Receptors, LH / Q000187:drug effects* / Q000378:metabolism; D013373:Substance P / Q000494:pharmacology*
D011974:Receptors, LH; D013373:Substance P; D007986:Luteinizing Hormone