Acidic fibroblast growth factor reduces rat skeletal muscle damage caused by ischemia and reperfusion.
Acute interruption of arterial blood flow to the extremities is often associated with significant morbidity and mortality. Broad-spectrum mitogenic and non-mitogenic activities of FGFs inspired us to study its protecting effects on tissue injuries in ischemia reperfusion condition. We found that systemic administration of aFGF after reperfusion onset prevented severe skeletal muscle injuries. In rats treated with aFGF, the tissue edema was reduced significantly, the tissue viability was increased, and the muscle fibers contained more succinate dehydrogenase (SDH) and adenosine triphosphatase (ATPase). The pathological results supported the concept of improved prevention with aFGF treatment. The possible tissue protection by aFGF may come from its ability to regulate the concentration of extra- and intracellular calcium ion. Besides, it may moderate other Ca2+ dependent enzyme conversion processes. Also, it may take part in the vascular tone regulation under ischemia and reperfusion conditions. These results suggest further study of tissue ischemia prevention with FGF and its possible mechanisms in the future.
Fu
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X
Trauma Center, Postgraduate Medical College, 304th Hospital, Beijing.
Cuevas
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P
Gimenez-Gallego
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G
Sheng
Z
Z
Tian
H
H
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D015220:Calcium Channels / Q000187:drug effects; D005121:Extremities / Q000098:blood supply; D016220:Fibroblast Growth Factor 1 / Q000494:pharmacology*; D008297:Male; D018482:Muscle, Skeletal / Q000201:enzymology / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*; D013385:Succinate Dehydrogenase / Q000378:metabolism
D015220:Calcium Channels; D016220:Fibroblast Growth Factor 1; D013385:Succinate Dehydrogenase; D000251:Adenosine Triphosphatases