title: The operative peritoneal fibrinolytic response to abdominal operation.
abstract: OBJECTIVE
  To measure changes in the fibrinolytic properties of human peritoneum during operation.
  
  
  METHODS
  Open study.
  
  
  METHODS
  University hospital, UK.
  
  
  METHODS
  20 patients undergoing elective operations for non-inflammatory disease.
  
  
  METHODS
  Peritoneum was biopsied at the beginning and end of operation.
  
  
  METHODS
  Peritoneal plasminogen activating activity (PAA) and the concentrations of tissue plasminogen activator (t-PA), urokinase, and plasminogen activator inhibitors 1 and 2 were measured at both time points.
  
  
  RESULTS
  Peritoneal PAA was reduced over the time of the operation (p < 0.05) as was the concentration of t-PA (p < 0.05). The urokinase concentration rose significantly (p < 0.05), but plasminogen activator inhibitors 1 and 2 were not detected.
  
  
  CONCLUSIONS
  Elective abdominal operation caused an immediate reduction in peritoneal PAA which seemed to be secondary to a reduced concentration of t-PA. Such a reduction in peritoneal fibrinolytic activity allows the early deposition of fibrinous deposits within the peritoneal cavity.
authors.affiliation: Department of Surgery, Hammersmith Hospital, London, England.
authors.forename: D M
authors.initials: DM
authors.lastname: Scott-Coombes
authors.forename: S A
authors.initials: SA
authors.lastname: Whawell
authors.forename: J N
authors.initials: JN
authors.lastname: Thompson
mesh_terms: D000005:Abdomen / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010537:Peritoneum / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism; D015849:Plasminogen Inactivators / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
chemical_list: D015849:Plasminogen Inactivators; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator