[Clinicopathological studies of anti-HCV P1P4 core antibody].
Anti-P1P4 core antibody, derived from a Japanese hepatitis C virus clone, was evaluated clinicopathologically in serum samples from 40 blood donors positive for anti-HCV antibody by 2nd generation assay and in 37 patients with HCV chronic hepatitis treated with interferon. The presence of anti-P1P4 antibody was highly correlated with the presence of HCV-RNA in the blood donors. In the patients with chronic hepatitis, more than a 50% reduction in P1P4 antibody titer after interferon therapy suggested the disappearance of HCV-RNA from the blood. Thus, anti-P1P4 antibody was useful in evaluating the virological effects of interferon therapy. However, clinically and pathologically, the titer of P1P4 antibody did not indicate the grade of liver inflammation.
Shibuya
A
A
Department of Internal Medicine, Kitasato University, School of Medicine, Sagamihara.
Asano
A
A
Tsuchihashi
T
T
Sakurai
K
K
Takeuchi
A
A
Shibata
H
H
D016174:Hepacivirus / Q000235:genetics; D006508:Hepatitis Antibodies / Q000032:analysis*; D006526:Hepatitis C / Q000175:diagnosis* / Q000628:therapy; D018937:Hepatitis C Antibodies; D006801:Humans; D007372:Interferons / Q000627:therapeutic use; D008099:Liver / Q000473:pathology; D012367:RNA, Viral / Q000032:analysis; D014758:Viral Core Proteins / Q000276:immunology
D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D012367:RNA, Viral; D014758:Viral Core Proteins; D007372:Interferons