Peptide cholesystokinin receptor antagonist increases food intake in rats.
An analogue of the C-terminal heptapeptide of cholecystokinin (CCK) t-Boc-Tyr(SO3-)-Nle-Gly-D-Trp-Nle-Asp-a-2-phenylethylester is a potent, specific CCK receptor antagonist. Intraperitoneal injection of the antagonist abolished suppression of real feeding and sham feeding by exogenous CCK-8 (1.8 nmol/kg), and significantly increased real feeding. Assuming an antagonist distribution like that of exogenous CCK-8, our results suggest that exogenous CCK-8 and endogenous CCK reduce food intake by acting at a site(s) accessible to peripherally administered peptides.
Brenner
L
L
Department of Veterinary and Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman 99164-6520, USA.
Ritter
R C
RC
D000595:Amino Acid Sequence; D000681:Amylases / Q000378:metabolism; D000818:Animals; D004435:Eating / Q000187:drug effects*; D008297:Male; D008969:Molecular Sequence Data; D010179:Pancreas / Q000201:enzymology; D010446:Peptide Fragments / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011949:Receptors, Cholecystokinin / Q000037:antagonists & inhibitors*; D012844:Sincalide / Q000031:analogs & derivatives* / Q000494:pharmacology
D010446:Peptide Fragments; D011949:Receptors, Cholecystokinin; C058451:JMV 180; D000681:Amylases; D012844:Sincalide