The effect of nasal mucosal vasoconstriction on nasal airflow sensation.
The correlation between the objective measurement of nasal resistance and nasal airflow sensation is usually regarded as poor. To investigate the relationship between these two parameters 20 healthy volunteers had nasal resistance to airflow measured by rhinomanometry compared with nasal sensation by visual analogue scoring before and after nasal mucosal vasoconstriction using topical 0.1% xylometazoline. The median change in nasal resistance was 0.2 kPal-1s (95% CI 0.08-0.28 kPal-1s) and in nasal sensation 24 mm (95% CI 17 mm-35 mm). A significant relationship between nasal sensation and nasal resistance to airflow was found (Kendall's Rank correlation (P < 0.05). This function can be described by the linear regression equation: dS = 13.2 + 70.dNR where dS = change in nasal sensation and dNR = change in nasal resistance. There may be a much closer relationship between subjective and objective measures of nasal patency than has previously been thought.
Clarke
R W
RW
Department of Otolaryngology, University of Liverpool, UK.
Cook
J A
JA
Jones
A S
AS
D000328:Adult; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D008297:Male; D014663:Nasal Decongestants; D009297:Nasal Mucosa / Q000187:drug effects; D012123:Pulmonary Ventilation; D014661:Vasoconstriction
D007093:Imidazoles; D014663:Nasal Decongestants; C009695:xylometazoline