Changes in tissue responsiveness to hormones and neurotransmitters during aging.
Responsiveness to many hormones and neurotransmitters by target tissues is altered during aging. Three model systems that are representative of these changes are reviewed. These are (1) striatal dopaminergic regulation of motor function, (2) IP3 and calcium-mediated electrolyte and neurosecretion by the alpha1-adrenergic and muscarinic cholinergic systems in parotid and corpus striatum, and (3) beta adrenergic and epidermal growth factor (EGF) stimulated DNA synthesis in hepatocytes.
Roth
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Molecular Physiology and Genetics Section, National Institute on Aging, Francis Scott Key Medical Center, Baltimore, Maryland 21224, USA.
D000375:Aging / Q000502:physiology*; D000818:Animals; D003342:Corpus Striatum / Q000502:physiology; D004247:DNA / Q000096:biosynthesis; D004298:Dopamine / Q000502:physiology; D006728:Hormones / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000378:metabolism; D008954:Models, Biological; D009043:Motor Activity / Q000502:physiology; D018377:Neurotransmitter Agents / Q000502:physiology*; D010306:Parotid Gland / Q000502:physiology; D051381:Rats; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D011976:Receptors, Muscarinic / Q000502:physiology
D006728:Hormones; D018377:Neurotransmitter Agents; D011942:Receptors, Adrenergic, alpha; D011976:Receptors, Muscarinic; D004247:DNA; D004298:Dopamine