Effect of lipophilicity of trichosporin-Bs on ion-channel formation and catecholamine-releasing activity.
A series of peptaibols, trichosporin (TS) -Bs, induced voltage-activated conductance in lipid bilayer membranes and catecholamine secretion from bovine adrenal chromaffin cells. The order of activities is the same as that of the lipophilicity rank of TS-Bs derived from the reversed-phase HPLC capacity factors.
Nagaoka
Y
Y
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Iida
A
A
Kambara
T
T
Tachikawa
E
E
Asami
K
K
Fujita
T
T
D000595:Amino Acid Sequence; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D002395:Catecholamines / Q000378:metabolism*; D002417:Cattle; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002838:Chromaffin System / Q000187:drug effects / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D007473:Ion Channels / Q000187:drug effects*; D008051:Lipid Bilayers; D008055:Lipids / Q000737:chemistry; D008969:Molecular Sequence Data; D010455:Peptides
D000900:Anti-Bacterial Agents; D002395:Catecholamines; D007473:Ion Channels; D008051:Lipid Bilayers; D008055:Lipids; D010455:Peptides