title: Occupational respiratory and skin sensitization caused by polyfunctional aziridine hardener.
abstract: Polyfunctional aziridine (PFA) is increasingly used as a water-based crosslinker in two-component paints, paint primers, lacquers, topcoats and other protective coatings. The crosslinker is made by reacting multifunctional acrylic monomer with a highly reactive aziridine compound. Respiratory allergy or hypersensitivity from PFA has not been reported previously. During 1978-1991 we came across nine cases with hypersensitivity from PFA: two had allergic contact dermatitis (ACD), four had occupational asthma and three had both of them. Five of the patients were parquet layers, two were fibreboard painters, one was a spray painter and one was a salesman of PFA products. ACD was diagnosed by positive allergic patch test reactions with PFA in a dilution series in petrolatum: 0.32%-0.5% gave a 2(+)-3+ allergic reaction in the five cases with ACD but 0.1% gave only a weak reaction in one case, whereas the methacrylate patch test series was negative. The diagnosis of seven cases of occupational asthma due to PFA hardener was based on symptoms related to exposure to PFA hardener at work, and on positive provocation tests with PFA hardener. One had an immediate type reaction, one a had a dual reaction, and the others had late reactions. The positive reactions with the PFA hardener and the negative reactions with the acrylate compounds indicate that PFA caused ACD which is different from the previous reports in which acrylates present as impurities in the PFA hardener caused the sensitization.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Finnish Institute of Occupational Health, Helsinki.
authors.forename: L
authors.initials: L
authors.lastname: Kanerva
authors.forename: H
authors.initials: H
authors.lastname: Keskinen
authors.forename: P
authors.initials: P
authors.lastname: Autio
authors.forename: T
authors.initials: T
authors.lastname: Estlander
authors.forename: M
authors.initials: M
authors.lastname: Tuppurainen
authors.forename: R
authors.initials: R
authors.lastname: Jolanki
mesh_terms: D000328:Adult; D001249:Asthma / Q000139:chemically induced; D001388:Aziridines / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology* / Q000276:immunology; D009783:Dermatitis, Occupational / Q000209:etiology* / Q000276:immunology; D005260:Female; D006801:Humans; D007114:Immunization; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000139:chemically induced* / Q000276:immunology; D010150:Paint / Q000009:adverse effects; D012130:Respiratory Hypersensitivity / Q000139:chemically induced* / Q000276:immunology; D012220:Rhinitis / Q000139:chemically induced; D012867:Skin / Q000187:drug effects / Q000276:immunology; D012882:Skin Tests
chemical_list: D001388:Aziridines