title: Resolution of ligature-induced peri-implantitis lesions in the dog.
abstract: The present experiment in the Labrador dog was performed to study tissue alterations that occurred in a peri-implantitis lesion following ligature removal. The study was carried out in 5, 1-year old Labrador dogs. The mandibular right and left 1st molars and 4th and 3rd premolars were extracted to establish recipient sites for implants. After 3 months of healing, 4 titanium fixtures, 2 in each jaw quadrant, were installed and abutment connection carried out in a 2nd stage procedure after another 3 months. After a 6-month period of healing, cotton floss ligatures were placed in a submarginal position around the neck of the fixture abutments. The ligatures were forced into a position "apical" of the margin of the peri-implant mucosa and secured. When the tissue destruction after 4-6 weeks was found to amount to about 25% of the original bone height at each individual implant, the ligatures were removed. 2 dogs were sacrificed 1 month and 3 dogs 3 months after ligature removal. The animals were perfused with a fixative and block biopsies were obtained from the implant sites. The biopsies were prepared for histometric and morphometric analyses.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Periodontology, Faculty of Odontology, University of Göteborg, Sweden.
authors.forename: C P
authors.initials: CP
authors.lastname: Marinello
authors.forename: T
authors.initials: T
authors.lastname: Berglundh
authors.forename: I
authors.initials: I
authors.lastname: Ericsson
authors.forename: B
authors.initials: B
authors.lastname: Klinge
authors.forename: P O
authors.initials: PO
authors.lastname: Glantz
authors.forename: J
authors.initials: J
authors.lastname: Lindhe
mesh_terms: D016301:Alveolar Bone Loss / Q000209:etiology* / Q000473:pathology*; D000539:Alveolar Process / Q000473:pathology; D000818:Animals; D001641:Bicuspid; D003094:Collagen; D003238:Connective Tissue / Q000473:pathology; D000044:Dental Abutments; D003758:Dental Implantation, Endosseous / Q000009:adverse effects*; D015921:Dental Implants / Q000009:adverse effects*; D004285:Dogs; D004848:Epithelium / Q000473:pathology; D005347:Fibroblasts / Q000473:pathology; D008026:Ligation / Q000295:instrumentation; D008963:Molar; D010514:Periodontal Pocket / Q000209:etiology / Q000473:pathology; D010518:Periodontitis / Q000209:etiology* / Q000473:pathology*; D010950:Plasma Cells / Q000473:pathology; D016459:Prosthesis-Related Infections / Q000209:etiology / Q000473:pathology; D014025:Titanium; D014945:Wound Healing
chemical_list: D015921:Dental Implants; D003094:Collagen; D014025:Titanium