[Thymus-like expression and molecules accessory to division and of thymocyte-stroma interactions in thymomas: a prerequisite for the establishment of an abnormal T-cell repertoire?].
Costimulatory stromal receptors were identified in thymuses and myasthenia gravis (MG)-associated thymic epithelial tumors (TETs) by immunohistochemistry. ICAM-1 occurred in areas with medullary or cortical differentiation of TETs and thymuses. B7 and LFA-3, absent in the normal cortex, were hyperexpressed in cortical type TETs. VCAM-1, confined to endothelium and dendritic cells in cortex and medulla, was focally expressed by epithelial cells of a medullary thymoma. We suggest that aberrantly expressed costimulatory molecules may contribute to the pathogenesis of paraneoplastic MG by an intratumorous activation of mature T cells.
Marx
A
A
Pathologisches Institut der Universität Würzburg.
Schömig
D
D
Schultz
A
A
Jung
A
A
Gattenlöhner
S
S
Brabletz
T
T
Kirchner
T
T
Müller-Hermelink
H K
HK
D015703:Antigens, CD / Q000032:analysis / Q000096:biosynthesis; D018968:CD58 Antigens; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000096:biosynthesis*; D002454:Cell Differentiation; D002455:Cell Division; D015870:Gene Expression; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis / Q000096:biosynthesis; D008562:Membrane Glycoproteins / Q000032:analysis / Q000096:biosynthesis; D012016:Reference Values; D013601:T-Lymphocytes / Q000166:cytology / Q000276:immunology* / Q000473:pathology*; D013945:Thymoma / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D013953:Thymus Neoplasms / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology; D019010:Vascular Cell Adhesion Molecule-1
D015703:Antigens, CD; D018968:CD58 Antigens; D015815:Cell Adhesion Molecules; D008562:Membrane Glycoproteins; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1