Flavipucine and brunnescin, two antibiotics from cultures of the mycophilic fungus Cladobotryum rubrobrunnescens.
Two antimicrobial metabolites were isolated from submerged cultures of Cladobotryum rubrobrunnescens, a mycophilic fungus growing on a Inocybe species. One of the compounds proved to be identical to flavipucine (2), an antibiotic previously isolated from Aspergillus flavipes (Casinovi et al., 1968) and from a Macrophoma species (Sassa T. and Onuma Y. (1983), Agric. Biol. Chem. 47, 1155-1157). The other metabolite, brunnescin (1), is a new tetrasubstituted furan derivative which exhibits antibacterial, antifungal and cytotoxic effects.
Wagner
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LB Biotechnologie Universität, Kaiserslautern, Bundesrepublik Deutschland.
Anke
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H
Besl
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H
Sterner
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O
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification; D001419:Bacteria / Q000187:drug effects; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D005285:Fermentation; D005658:Fungi / Q000187:drug effects; D005663:Furans / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D006801:Humans; D007939:Leukemia L1210; D015471:Leukemia, Basophilic, Acute; D015470:Leukemia, Myeloid, Acute; D051379:Mice; D008826:Microbial Sensitivity Tests; D003904:Mitosporic Fungi / Q000302:isolation & purification / Q000502:physiology; D015394:Molecular Structure; D011728:Pyridones / Q000737:chemistry / Q000302:isolation & purification / Q000633:toxicity; D051381:Rats; D014407:Tumor Cells, Cultured
D000900:Anti-Bacterial Agents; D005663:Furans; D011728:Pyridones; C096045:brunnescin; C002860:flavipucine