1'-Acetoxychavicol acetate as an inhibitor of phagocytosis of macrophages.
We screened extracts of edible plants for inhibitors of phagocytosis by peritoneal exudate macrophages. 1'-Acetoxychavicol acetate was isolated from the ethyl acetate extract of Languas galanga, and this compound strongly inhibited phagocytosis at an IC50 value of 1.2 microM with negligible effects on pinocytosis and cell viability. Target(s) of 1'-acetoxychavicol acetate was suggested to be downstream of the signal transduction pathway that is mediated by protein kinase C.
Watanabe
N
N
Department of Bioengineering, Tokyo Institute of Technology, Kanagawa, Japan.
Kataoka
T
T
Tajika
T
T
Uramoto
M
M
Magae
J
J
Nagai
K
K
D000818:Animals; D001592:Benzyl Alcohols; D002478:Cells, Cultured; D005260:Female; D008264:Macrophages / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D008809:Mice, Inbred C3H; D010587:Phagocytosis / Q000187:drug effects*; D010936:Plant Extracts / Q000494:pharmacology*; D017365:Spices; D013329:Structure-Activity Relationship; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*
D001592:Benzyl Alcohols; D010936:Plant Extracts; D013729:Terpenes; C047948:1'-acetoxychavicol acetate