title: [Physiopathology of BPH obstruction].
abstract: The underlying BPH related mechanisms of outlet obstruction are outlined (modification of the shape of the bladder neck, failure of funnel formation, geometric variations of the urethra, alpha 1 adrenoceptors mediated sympathetic hyperactivity at the level of the lower genito-urinary tract). Bladder voiding dysfunction in response to prostate obstruction is also discussed and correlated to ultrastructural patterns and clinical symptoms. Finally, a pathogenetic mechanism for detrusor overactivity in obstructed bladder is suggested.
authors.affiliation: U.O. di Urologia, U.S.S.L. n. 8, Busto Arsizio.
authors.forename: A
authors.initials: A
authors.lastname: Zaroli
authors.forename: A
authors.initials: A
authors.lastname: Mandressi
authors.forename: M
authors.initials: M
authors.lastname: Belloni
authors.forename: D
authors.initials: D
authors.lastname: Antonelli
authors.forename: S
authors.initials: S
authors.lastname: Bernasconi
authors.forename: C
authors.initials: C
authors.lastname: Buizza
authors.forename: S
authors.initials: S
authors.lastname: Chisena
mesh_terms: D006801:Humans; D008297:Male; D008954:Models, Biological; D011470:Prostatic Hyperplasia / Q000473:pathology / Q000503:physiopathology*; D001743:Urinary Bladder / Q000503:physiopathology / Q000648:ultrastructure