Immunohistochemical appearance of corticosteroid contact hypersensitivity reactions.
We have studied, immunohistochemically, hypersensitivity reactions to corticosteroids and compared them with allergic contact dermatitis from nickel and appropriate controls. We could find no qualitative differences between nickel and corticosteroid contact reactions, providing further evidence that hypersensitivity to corticosteroids is an immunologically mediated reaction.
Wilkinson
S M
SM
Skin Hospital, Salford, UK.
Andrew
S M
SM
Maseruka
H
H
Beck
M H
MH
D000287:Administration, Topical; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D015815:Cell Adhesion Molecules / Q000235:genetics / Q000378:metabolism*; D017449:Dermatitis, Allergic Contact / Q000209:etiology* / Q000378:metabolism / Q000473:pathology*; D019040:E-Selectin; D004727:Endothelium / Q000378:metabolism / Q000473:pathology; D015870:Gene Expression; D006801:Humans; D006854:Hydrocortisone / Q000009:adverse effects* / Q000031:analogs & derivatives*; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000235:genetics / Q000378:metabolism; D007509:Irritants / Q000009:adverse effects; D015603:Keratinocytes / Q000378:metabolism / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008562:Membrane Glycoproteins / Q000235:genetics / Q000378:metabolism; D009532:Nickel / Q000009:adverse effects; D011971:Receptors, Immunologic / Q000235:genetics / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D007509:Irritants; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D018799:Intercellular Adhesion Molecule-1; C029938:nickel sulfate; C019112:tixocortol pivalate; D009532:Nickel; D006854:Hydrocortisone