Priming with interferon-alpha 1 or interferon-alpha 2 enhances the production of both subtypes simultaneously.
A short period of incubation with interferon-alpha ("priming") increases the amounts of IFN-alpha formed by human peripheral blood leukocytes when subsequently induced with a virus. We investigated specifically the effect of priming on the production of two individual subtypes, IFN-alpha 1 and IFN-alpha 2. The rate of interferon synthesis and the amounts formed were equally potentiated in leukocytes primed with either IFN-alpha 1 or IFN-alpha 2. Whichever of these was used for priming had no selective effect on the relative increased production of IFN-alpha 1 or IFN-alpha 2.
Fuchsberger
N
N
Institute of Virology, Slovak Academy of Sciences, Bratislava.
Karayianni-Vasconcelos
G
G
Kauppinen
H L
HL
Hajnicka
V
V
Kontsek
P
P
D000911:Antibodies, Monoclonal; D000918:Antibody Specificity; D000998:Antiviral Agents / Q000097:blood / Q000494:pharmacology*; D006801:Humans; D016898:Interferon-alpha / Q000096:biosynthesis / Q000494:pharmacology*; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism
D000911:Antibodies, Monoclonal; D000998:Antiviral Agents; D016898:Interferon-alpha