[Role of autoantibody in preeclampsia].
The role of anti-ssDNA and dsDNA antibody in preeclampsia were studied. Serum samples were taken from 38 pregnants with preeclampsia including 19 cases of severe type. Also, 26 normal pregnant women were studied as the control. Anti-ssDNA and dsDNA antibody were measured by enzyme-linked immunosorbent assay (ELISA). Anti-phospholipid antibody (APA), was measured by ELISA. Anti-dsDNA antibody was positive in 1 of the 38 preeclampsia. Anti-ssDNA antibody was positive in 15 out of the 38 cases (39.4%) in preeclampsia. Incidence of anti-ssDNA positive preeclampsia is related to it's severity of symptom as following: Six of 19 mild preeclampsia (26.3%) were positive. In severe cases, 10 of 19 (52.6%). However, the relationship between anti-ssDNA antibody and IUGR in preeclampsia, was not confirmed, although the antiphospholipid antibody was related to the IUGR. From these results, we concluded that the autoantibody, such as anti-DNA antibody, might be produced in preeclampsia and the B cell activation might play a role of exaggeration of preeclampsia.
Yamamoto
T
T
Department of Obstetrics and Gynecology, Teikyo University School of Medicine.
Yoshimura
S
S
Geshi
Y
Y
Mori
H
H
D000974:Antibodies, Antinuclear / Q000032:analysis; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D001323:Autoantibodies / Q000032:analysis / Q000502:physiology*; D001402:B-Lymphocytes / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D011225:Pre-Eclampsia / Q000276:immunology*; D011247:Pregnancy
D000974:Antibodies, Antinuclear; D017152:Antibodies, Antiphospholipid; D001323:Autoantibodies