Effects of systemic cell-mediated immunity on vaginal candidiasis in mice resistant and susceptible to Candida albicans infections.
Studies to date with CBA/J mice suggest a limited role for systemic cell-mediated immunity (CMI) against vaginal Candida albicans infections. The results of the present study show that preinduced Candida-specific systemic CMI was equally nonprotective against C. albicans vaginal infections in mice with high (BALB/cJ), low (DBA/2), or intermediate (CBA/J) resistance to C. albicans infections. Similarly, the locally acquired partial protection against a second C. albicans vaginal infection was equally observed with BALB/cJ, DBA/2, and CBA/J mice. These results indicate that observations made previously with CBA/J mice were not murine strain specific and provide additional support for the hypothesis that systemic CMI does not represent a dominant host defense mechanism at the vaginal mucosa.
Fidel
P L
PL
Division of Infectious Diseases, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
Cutright
J L
JL
Sobel
J D
JD
D000818:Animals; D002181:Candidiasis, Vulvovaginal / Q000276:immunology*; D004198:Disease Susceptibility; D005260:Female; D006968:Hypersensitivity, Delayed; D007111:Immunity, Cellular; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008811:Mice, Inbred DBA; D013045:Species Specificity; D014621:Vagina / Q000276:immunology