Effects of the prostacyclin analogue iloprost on patency in small arteries and veins: an experimental study in the rabbit.
Arteriotomy/intimectomy and venotomy/intimectomy were performed in the ears of 43 rabbits. Twenty were treated with iloprost given as intravenous doses of 10 micrograms/kg body weight (bw) administered shortly before reperfusion followed by hourly infusions (3 micrograms/kg b w) until 12 hrs after reperfusion. At reperfusion venous and arterial bleeding times were noted. Patency was determined at 15-min intervals until 2 hrs after reperfusion and at 1 and 2 weeks postoperatively. As controls, 23 rabbits were given a single infusion of saline. Compared to controls, iloprost significantly prolonged arterial and venous bleeding times and significantly improved patency 2 hrs after reperfusion. One and two weeks later, however, virtually all vessels were occluded. Administered in this fashion, iloprost does not improve long-term patency in highly traumatized small veins and arteries.
Salemark
L
L
Department of Plastic and Reconstructive Surgery, Malmö General Hospital, Sweden.
Knudsen
F
F
Dougan
P
P
D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D001794:Blood Pressure / Q000187:drug effects; D004431:Ear, External / Q000098:blood supply*; D005260:Female; D006470:Hemorrhage / Q000503:physiopathology; D016285:Iloprost / Q000008:administration & dosage / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D011817:Rabbits; D012039:Regional Blood Flow / Q000187:drug effects; D015424:Reperfusion; D013927:Thrombosis / Q000503:physiopathology; D013997:Time Factors; D017539:Tunica Intima / Q000187:drug effects / Q000473:pathology / Q000601:surgery; D014654:Vascular Patency / Q000187:drug effects*; D014680:Veins / Q000187:drug effects / Q000473:pathology / Q000601:surgery
D016285:Iloprost