Immediate-early genes induced by antigen receptor stimulation.
Immediate early genes induced by triggering of the TCR frequently encode proteins that act in signal transduction cascades. Recent advances concerning several immediate-early proteins have been made, including signal-induced regulation of NF-kappa B by I kappa-B, the role of Nur77 in T-cell selection and apoptosis, and the function of PAC-1 in regulating the Ras/ERK pathway.
Kelly
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Laboratory of Pathology, National Institutes of Health, Bethesda, MD 20892, USA.
Siebenlist
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U
D017871:Calcium-Calmodulin-Dependent Protein Kinases / Q000235:genetics / Q000276:immunology; D015536:Down-Regulation; D054641:Dual Specificity Phosphatase 2; D048049:Extracellular Signal-Regulated MAP Kinases; D015870:Gene Expression; D017781:Genes, Immediate-Early / Q000235:genetics* / Q000276:immunology; D006801:Humans; D020930:MAP Kinase Kinase Kinases; D008957:Models, Genetic; D018448:Models, Immunological; D054648:Protein Phosphatase 2; D017027:Protein Tyrosine Phosphatases / Q000235:genetics / Q000276:immunology; D011946:Receptors, Antigen / Q000235:genetics* / Q000276:immunology; D015398:Signal Transduction; D014157:Transcription Factors
D011946:Receptors, Antigen; D014157:Transcription Factors; D017871:Calcium-Calmodulin-Dependent Protein Kinases; D048049:Extracellular Signal-Regulated MAP Kinases; D020930:MAP Kinase Kinase Kinases; C089319:Ras-dependent mitogen-activated protein kinase kinase kinase; D054648:Protein Phosphatase 2; C517032:DUSP2 protein, human; D054641:Dual Specificity Phosphatase 2; D017027:Protein Tyrosine Phosphatases