title: Zygomycotic lung abscess: a case report.
abstract: Zygomycosis is an uncommon, but frequently fatal, fungal infection caused by members of the class Zygomycetes. The risk factors include diabetes mellitus, uremia, leukemia and use of deferoxamine as an iron-chelating agent; healthy persons also are occasionally infected. Those fungi, spread by their ubiquitous spores, most frequently involve the respiratory system. Rhinocerebral zygomycosis occurs predominantly in patients with uncontrolled diabetic ketoacidosis. Pulmonary zygomycosis most frequently is observed in granulocytopenic and corticosteroid-treated patients. Other clinical manifestations are gastrointestinal, cutaneous, disseminated and miscellaneous. This report concerns a previously robust farmer who suffered from left upper lung abscess caused by Rhizopus spp.-one member of the order Mucorales. Initially, it was intended to administer amphotericin B to a total dose of 2,000 mg; however, the patient could not tolerate such side effects as nausea, vomiting and refused further management when the cumulative dose was 948 mg. However, he did recover without further fever and cough. Chest X-ray, followed every three months, disclosed satisfactory improvement.
authors.affiliation: Department of Internal Medicine, Veterans General Hospital-Kaohsiung, Kaohsiung, Taiwan, R.O.C.
authors.forename: J S
authors.initials: JS
authors.lastname: Chen
authors.forename: C C
authors.initials: CC
authors.lastname: Lin
authors.forename: S L
authors.initials: SL
authors.lastname: Lin
authors.forename: J Y
authors.initials: JY
authors.lastname: Lu
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use*; D000935:Antifungal Agents / Q000627:therapeutic use*; D006801:Humans; D008169:Lung Abscess / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000188:drug therapy*
chemical_list: D000935:Antifungal Agents; D000666:Amphotericin B