title: Bryostatin 1 enhances lymphokine activated killer sensitivity and modulates the beta 1 integrin profile of cultured human tumor cells.
abstract: Bryostatin 1 interferes with protein kinase C (PKC) signaling which is involved in the activation of human and murine cytotoxic T lymphocytes, and in the growth and differentiation of tumor cells. Bryostatin 1 has immunomodulating and antitumor properties as demonstrated by preclinical and clinical studies. Here we report that bryostatin 1 increases the susceptibility to lymphokine activated killers and modifies the pattern of beta 1 integrin expression of human tumor cells. On the basis of these results the use of bryostatin 1 in combination with immunostimulating cytokines such as interleukin-2 in the treatment of human cancer is suggested.
authors.affiliation: Dipartimento di Endocrinologia ed Oncologia Molecolare e Clinica, Università Federico II, Napoli, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Correale
authors.forename: M
authors.initials: M
authors.lastname: Caraglia
authors.forename: A
authors.initials: A
authors.lastname: Fabbrocini
authors.forename: R
authors.initials: R
authors.lastname: Guarrasi
authors.forename: S
authors.initials: S
authors.lastname: Pepe
authors.forename: V
authors.initials: V
authors.lastname: Patella
authors.forename: G
authors.initials: G
authors.lastname: Marone
authors.forename: A
authors.initials: A
authors.lastname: Pinto
authors.forename: A R
authors.initials: AR
authors.lastname: Bianco
authors.forename: P
authors.initials: P
authors.lastname: Tagliaferri
mesh_terms: D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000970:Antineoplastic Agents / Q000494:pharmacology*; D054713:Bryostatins; D006801:Humans; D019012:Integrin beta1; D016023:Integrins / Q000032:analysis*; D015979:Killer Cells, Lymphokine-Activated / Q000187:drug effects*; D007783:Lactones / Q000494:pharmacology*; D018942:Macrolides; D014407:Tumor Cells, Cultured
chemical_list: D000276:Adjuvants, Immunologic; D000970:Antineoplastic Agents; D054713:Bryostatins; D019012:Integrin beta1; D016023:Integrins; D007783:Lactones; D018942:Macrolides; C046785:bryostatin 1