Pathophysiology of fibrinolysis.
The observed association between abnormal fibrinolysis and a tendency toward bleeding or thrombosis demonstrates the (patho)physiological importance of the fibrinolytic system. Deficient fibrinolysis represents an important haemostatic abnormality associated with thrombosis. A decreased fibrinolytic activity may be due to a defective synthesis and/or release of tissue-type plasminogen activator (t-PA) from the vessel wall, to a deficiency or functional defect in the plasminogen or fibrinogen molecule or more frequently to increased levels of t-PA inhibitor. Alternatively, excessive fibrinolysis due to increased levels of t-PA, to alpha 2-antiplasmin deficiency or to plasminogen activator inhibitor-1 (PAI-1) deficiency, may result in bleeding tendency.
Juhan-Vague
I
I
Laboratoire d'Hématologie, CHU Timone, Marseille, France.
Alessi
M C
MC
Declerck
P J
PJ
D000347:Afibrinogenemia; D000818:Animals; D001778:Blood Coagulation Disorders; D005342:Fibrinolysis; D006470:Hemorrhage / Q000209:etiology; D006801:Humans; D010958:Plasminogen / Q000172:deficiency; D013927:Thrombosis / Q000209:etiology; D000979:alpha-2-Antiplasmin / Q000172:deficiency
D000979:alpha-2-Antiplasmin; D010958:Plasminogen