title: A delayed hypersensitivity reaction to dentine primer in the guinea-pig.
abstract: OBJECTIVE
  This study was undertaken to examine the possibility of a delayed hypersensitivity reaction or contact dermatitis occurring in the guinea-pig in response to methacrylate derivatives used as experimental dentine primers.
  
  
  METHODS
  The dentine primers 2-HEMA, GM, MA and MMA were tested in a guinea-pig maximization test.
  
  
  RESULTS
  All the dentine primers tested produced positive delayed hypersensitivity reactions in the guinea-pig. MMA produced the most severe reaction.
  
  
  CONCLUSIONS
  It is concluded that in the clinical situation, clinicians and other members of the dental team should be aware of the need for careful handling of the dentine primers tested.
authors.affiliation: Department of Operative Dentistry, School of Dentistry, Showa University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Katsuno
authors.forename: A
authors.initials: A
authors.lastname: Manabe
authors.forename: K
authors.initials: K
authors.lastname: Itoh
authors.forename: H
authors.initials: H
authors.lastname: Hisamitsu
authors.forename: S
authors.initials: S
authors.lastname: Wakumoto
authors.forename: S
authors.initials: S
authors.lastname: Nakayama
authors.forename: T
authors.initials: T
authors.lastname: Yoshida
mesh_terms: D000818:Animals; D017220:Dentin-Bonding Agents / Q000009:adverse effects*; D003877:Dermatitis, Contact / Q000209:etiology / Q000473:pathology; D004487:Edema / Q000209:etiology / Q000473:pathology; D004890:Erythema / Q000209:etiology / Q000473:pathology; D005620:Freund's Adjuvant; D005989:Glycerides / Q000009:adverse effects; D006168:Guinea Pigs; D006968:Hypersensitivity, Delayed / Q000209:etiology* / Q000473:pathology; D007114:Immunization; D008689:Methacrylates / Q000009:adverse effects*; D020366:Methylmethacrylate; D008768:Methylmethacrylates / Q000009:adverse effects; D051379:Mice; D008807:Mice, Inbred BALB C; D010328:Patch Tests; D012867:Skin / Q000187:drug effects / Q000473:pathology
chemical_list: D017220:Dentin-Bonding Agents; D005989:Glycerides; D008689:Methacrylates; D008768:Methylmethacrylates; D020366:Methylmethacrylate; C069750:glyceryl methacrylate; C005044:hydroxyethyl methacrylate; D005620:Freund's Adjuvant