Effect of a new non-steroidal anti-inflammatory drug, nitroflurbiprofen, on the expression of inducible nitric oxide synthase in rat neutrophils.
The effects of a non-steroidal anti-inflammatory drug, flurbiprofen, and its nitro-derivative, nitroflurbiprofen, on inducible nitric oxide synthase in rat neutrophils were examined. Nitroflurbiprofen was shown to inhibit nitric oxide synthase induction caused by lipopolysaccharide administration, while flurbiprofen had no effect on nitric oxide synthase induction. This inhibitory action may be ascribed to nitric oxide released from nitroflurbiprofen.
Mariotto
S
S
Istituto di Chimica Biologica, Università di Verona, Italy.
Cuzzolin
L
L
Adami
A
A
Del Soldato
P
P
Suzuki
H
H
Benoni
G
G
D000284:Administration, Oral; D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis*; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D002469:Cell Separation; D002499:Centrifugation, Density Gradient; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D005480:Flurbiprofen / Q000031:analogs & derivatives* / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000633:toxicity; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D009566:Nitrates / Q000097:blood; D019001:Nitric Oxide Synthase; D009573:Nitrites / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley
D000894:Anti-Inflammatory Agents, Non-Steroidal; D008070:Lipopolysaccharides; D009566:Nitrates; D009573:Nitrites; C095631:nitroflurbiprofen; D005480:Flurbiprofen; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases