title: TCRBV12 genes are polymorphic but the protein products encoded by each gene are conserved.
abstract: The human TCRBV gene complex contains three BV12 genes and all are polymorphic. There are two alleles of BV12S4; one allele contains a stop codon in the coding region which precludes its expression. There are four alleles of BV12S2 and two alleles of BV12S3 genes; however, the substitutions present in both genes are conservative. Although allelic variants exist for each of the three BV12 genes, only one protein product is encoded by each gene.
authors.affiliation: Laboratory of Immunogenetics, Twinbrook II Facility, National Institute of Allergy and Infectious Diseases, Rockville, MD 20852, USA.
authors.forename: H
authors.initials: H
authors.lastname: Deulofeut
authors.forename: J L
authors.initials: JL
authors.lastname: Wilderson
authors.forename: K S
authors.initials: KS
authors.lastname: Barron
authors.forename: M A
authors.initials: MA
authors.lastname: Robinson
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D001483:Base Sequence; D017124:Conserved Sequence; D015870:Gene Expression; D005787:Gene Frequency; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000096:biosynthesis / Q000235:genetics*
chemical_list: D016693:Receptors, Antigen, T-Cell, alpha-beta