Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development.
The Wnt gene family encodes a set of signalling molecules implicated in the development of a wide range of organisms. We have recently cloned partial cDNA sequences of murine Wnt-11 and Wnt-12. Here, we describe the spatio-temporal expression patterns of both genes during mouse embryogenesis. Wnt-11 expression is first detected within the truncus arteriosus from 8.25 dpc. By 9.5 dpc, Wnt-11 expression is detected in the somites at the medial junction of the dermatome and the myotome. Wnt-11 transcripts are also detected in limb bud mesenchyme from the time the bud is first visible. Wnt-12 is detected in the apical ectodermal ridge from 10.5 dpc. The implications of these expression patterns are discussed.
Christiansen
J H
JH
Centre for Molecular and Cellular Biology, University of Queensland, St. Lucia, Australia.
Dennis
C L
CL
Wicking
C A
CA
Monkley
S J
SJ
Wilkinson
D G
DG
Wainwright
B J
BJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018076:DNA, Complementary / Q000235:genetics; D005314:Embryonic and Fetal Development / Q000235:genetics*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D006023:Glycoproteins; D017403:In Situ Hybridization; D051379:Mice; D008813:Mice, Inbred ICR; D008969:Molecular Sequence Data; D011247:Pregnancy; D011506:Proteins / Q000235:genetics*; D011518:Proto-Oncogene Proteins; D016364:Reading Frames; D017386:Sequence Homology, Amino Acid; D051153:Wnt Proteins
D018076:DNA, Complementary; D006023:Glycoproteins; D011506:Proteins; D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; C102068:Wnt10b protein, mouse