Administration of granulocyte colony-stimulating factor to neutropenic low birth weight infants of mothers with preeclampsia.
Nine low birth weight infants with neutropenia born to mothers with preeclampsia were treated with granulocyte-colony stimulating factor, 10 micrograms/kg intravenously, within 24 hours of birth and at 24-hour intervals for a maximum of three doses if neutropenia persisted. The absolute neutrophil count increased significantly in eight of the nine infants within 6 hours, and neutrophilia was sustained for at least 72 hours after administration of a single dose of granulocyte-colony stimulating factor.
Makhlouf
R A
RA
Department of Pediatrics, University of North Carolina at Chapel Hill 27599-7596.
Doron
M W
MW
Bose
C L
CL
Price
W A
WA
Stiles
A D
AD
D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use*; D006801:Humans; D007230:Infant, Low Birth Weight / Q000097:blood; D007231:Infant, Newborn; D007958:Leukocyte Count; D009503:Neutropenia / Q000209:etiology / Q000628:therapy*; D009504:Neutrophils; D011225:Pre-Eclampsia; D011247:Pregnancy
D016179:Granulocyte Colony-Stimulating Factor