Clinical efficacy of Tranilast on otitis media with effusion in children.
In this open randomized study, we evaluated the efficacy of Tranilast, one of the anti-inflammatory drugs, on otitis media with effusion in children. Sixty-two patients (103 ears) were divided into two groups: Group A was given Tranilast and local treatment (nasal and tubal); Group B only received local treatment (control for Group A). The overall improvement rating assessed as "moderately improved or above" for Group A was 63.6%, Group B 47.9%. There was a significant improvement in Group A as compared to Group B (p < 0.05). In subjects who suffered from otitis media with effusion for over 2 months. Group A exhibited 50.0% of efficacy while Group B only 15.4% (p < 0.05).
Hisamatsu
K
K
Department of Otorhinolaryngology, Yamanashi Medical University, Japan.
Ganbo
T
T
Nakazawa
T
T
Goto
R
R
Ogino
J
J
Nozawa
I
I
Murakami
Y
Y
D000158:Acoustic Impedance Tests; D000293:Adolescent; D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology / Q000627:therapeutic use*; D001299:Audiometry; D002648:Child; D002675:Child, Preschool; D004432:Ear, Middle / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D010034:Otitis Media with Effusion / Q000188:drug therapy* / Q000503:physiopathology; D016896:Treatment Outcome; D014432:Tympanic Membrane / Q000187:drug effects; D062367:ortho-Aminobenzoates / Q000494:pharmacology / Q000627:therapeutic use*
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D062367:ortho-Aminobenzoates; C012293:tranilast