title: Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice.
abstract: Airway hyperresponsiveness is a key characteristic of human asthma and a marker for asthma-like conditions in animals. F1 mice derived from A/J and C57BL/6J display a phenotype which resembles the asthma-like phenotype of the A/J mice. Since airway responsiveness failed to segregate as a mendelian trait, we show significant linkage at two loci, Bhr1 (lod = 3.0) and Bhr2 (lod = 3.7) on chromosomes 2 and 15. A third locus, Bhr3 (lod = 2.83), maps to chromosome 17. Each of these loci maps near candidate loci implicated in the pathobiology of asthma. Our study represents the first linkages established through a genome-wide survey of airway hyperresponsiveness in any mammal.
authors.affiliation: Combined Program in Pulmonary and Critical Care Medicine, Brigham Women's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: G T
authors.initials: GT
authors.lastname: De Sanctis
authors.forename: M
authors.initials: M
authors.lastname: Merchant
authors.forename: D R
authors.initials: DR
authors.lastname: Beier
authors.forename: R D
authors.initials: RD
authors.lastname: Dredge
authors.forename: J K
authors.initials: JK
authors.lastname: Grobholz
authors.forename: T R
authors.initials: TR
authors.lastname: Martin
authors.forename: E S
authors.initials: ES
authors.lastname: Lander
authors.forename: J M
authors.initials: JM
authors.lastname: Drazen
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001249:Asthma / Q000235:genetics* / Q000503:physiopathology*; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004247:DNA / Q000032:analysis / Q000302:isolation & purification; D005260:Female; D008040:Genetic Linkage; D005838:Genotype; D006801:Humans; D007668:Kidney / Q000378:metabolism; D008126:Lod Score; D008168:Lung / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008322:Mammals; D016210:Methacholine Chloride / Q000494:pharmacology; D051379:Mice; D008805:Mice, Inbred A; D008810:Mice, Inbred C57BL; D010277:Parasympathomimetics / Q000494:pharmacology; D010641:Phenotype; D010991:Plethysmography; D016133:Polymerase Chain Reaction; D012129:Respiratory Function Tests
chemical_list: D010277:Parasympathomimetics; D016210:Methacholine Chloride; D004247:DNA