[CD5+B cells and autoimmune diseases].
By using two colour flow cytometric analysis, we examined the proportion of B lymphocytes bearing CD5 surface antigen (CD5+B cell). The level of CD5+B cells was markedly increased in active chronic ITP and active hyperthyroid patients with Graves' disease. There was an inverse correlation between the percentage of circulating CD5+B cells and platelet counts, and a positive correlation between the level of CD5+B cells in peripheral blood and serum T3 level. These results suggested that the level of CD5+B cells might play a role in producing autoantibodies in some autoimmune diseases.
Yu
J R
JR
Department of Medicine, First Hospital, Beijing Medical University.
Qiu
Z X
ZX
Yang
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D018956:CD5 Antigens; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D006980:Hyperthyroidism / Q000276:immunology; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D011696:Purpura, Thrombocytopenic / Q000276:immunology; D014284:Triiodothyronine / Q000097:blood
D015703:Antigens, CD; D018956:CD5 Antigens; D014284:Triiodothyronine