title: Gamma globulin administration in relapsing Clostridium difficile-induced pseudomembranous colitis with a defective antibody response to toxin A.
abstract: A 53-year-old woman suffered six episodes of Clostridium difficile-pseudomembranous colitis. The serological follow-up demonstrated the absence of a rise in IgG and IgA to toxin A. Human pooled gamma globulin was administered during the fifth relapse and raised IgG levels to toxin A. Normal stools reappeared a week later. The role of the antibodies to toxin A and gamma globulin in C. difficile colitis are discussed.
authors.affiliation: Département de Microbiologie, Université Catholique de Louvain, Bruxelles, Belgique.
authors.forename: M
authors.initials: M
authors.lastname: Warny
authors.forename: C
authors.initials: C
authors.lastname: Denie
authors.forename: M
authors.initials: M
authors.lastname: Delmée
authors.forename: C
authors.initials: C
authors.lastname: Lefebvre
mesh_terms: D001427:Bacterial Toxins / Q000276:immunology*; D016360:Clostridioides difficile / Q000276:immunology; D004761:Enterocolitis, Pseudomembranous / Q000276:immunology / Q000382:microbiology / Q000628:therapy*; D005260:Female; D006801:Humans; D008875:Middle Aged; D012008:Recurrence; D005719:gamma-Globulins / Q000627:therapeutic use*
chemical_list: D001427:Bacterial Toxins; D005719:gamma-Globulins