Neutrophil-mediated platelet activation: a key role for serine proteinases.
1. Neutrophils and platelets interact in vitro through multiple biochemical pathways in both directions, resulting in an inhibition or a potentiation of their reactivity, depending on the experimental conditions. 2. Under some conditions, a full stimulation of platelets (aggregation and degranulation) can be induced by neutrophils. The present review is focused on this aspect for which serine proteinases released from the azurophilic granules of neutrophils activate surrounding platelets. 3. The different facets of this process at the cellular and molecular levels, are presently depicted and their relevance to the in vivo situation suggested.
Renesto
P
P
Unité de Pharmacologie Cellulaire, Unité associée IP/INSERM 285, Institut Pasteur, Paris, France.
Chignard
M
M
D000818:Animals; D006801:Humans; D009504:Neutrophils / Q000201:enzymology* / Q000502:physiology*; D015539:Platelet Activation / Q000502:physiology*; D012697:Serine Endopeptidases / Q000502:physiology*
D012697:Serine Endopeptidases