title: Expression of acidic FGF mRNA in rat auditory brainstem during postnatal maturation.
abstract: In situ hybridization was used to investigate the mRNA distribution of acidic and basic fibroblast growth factor (aFGF and bFGF) in the auditory brainstem of neonatal and adult rats. bFGF mRNA was not detected at any age. In adult rats, aFGF mRNA was strongly expressed in the principal neurons of the anteroventral and posteroventral cochlear nuclei, but not in the octopus cells. In the dorsal cochlear nucleus, aFGF mRNA was seen only in scattered smaller vertical cells. aFGF was strongly expressed in the nucleus of the trapezoid body and in all periolivary cell groups, but not in the medial and lateral olivary nuclei. No expression was observed in the lemniscal nuclei or in the central nucleus of the inferior colliculus, but large neurons in the external zone of the colliculus were labeled. Developmentally, low levels of aFGF expression appeared in the cochlear nuclei and olivary nuclei between P0 and P6. This expression increased rapidly during the onset of hearing, between P10 and P14, and reached adult level by P14-P17. Labeling in collicular neurons appeared slightly later. The results suggest that the appearance of strong aFGF mRNA expression is related to the onset of function.
authors.affiliation: Department of Surgery, UCSD School of Medicine, La Jolla 92093-0666, USA.
authors.forename: L
authors.initials: L
authors.lastname: Luo
authors.forename: J K
authors.initials: JK
authors.lastname: Moore
authors.forename: A
authors.initials: A
authors.lastname: Baird
authors.forename: A F
authors.initials: AF
authors.lastname: Ryan
mesh_terms: D000375:Aging / Q000502:physiology*; D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D001306:Auditory Pathways / Q000502:physiology*; D001345:Autoradiography; D001933:Brain Stem / Q000502:physiology*; D016220:Fibroblast Growth Factor 1 / Q000235:genetics* / Q000378:metabolism; D015870:Gene Expression; D017403:In Situ Hybridization; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D014018:Tissue Distribution
chemical_list: D012333:RNA, Messenger; D016220:Fibroblast Growth Factor 1