title: Human P-glycoprotein as a multi-drug transporter analyzed by using transepithelial transport system.
abstract: To analyze the mechanism of drug transport, mechanism of inhibitors, and physiological substrates of human P-glycoprotein, we established a transepithelial transport system by introducing MDR1 cDNA into LLC-PK1, a pig kidney epithelial cell line. P-glycoprotein functions as a steroid transporter as well as a drug transporter as physiological functions. P-glycoprotein also transports MDR modulators such as cyclosporin A, FK506, and calcium channel blockers.
authors.affiliation: Department of Agricultural Chemistry, Kyoto University Hospital, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Saeki
authors.forename: M
authors.initials: M
authors.lastname: Hirai
authors.forename: Y
authors.initials: Y
authors.lastname: Tanigawara
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Okamura
authors.forename: M
authors.initials: M
authors.lastname: Yasuhara
authors.forename: R
authors.initials: R
authors.lastname: Hori
authors.forename: K
authors.initials: K
authors.lastname: Inui
authors.forename: T
authors.initials: T
authors.lastname: Komano
mesh_terms: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D002352:Carrier Proteins; D016572:Cyclosporine / Q000494:pharmacology; D018432:Drug Resistance, Multiple; D004848:Epithelium; D006801:Humans; D006854:Hydrocortisone / Q000494:pharmacology; D016559:Tacrolimus / Q000494:pharmacology; D014747:Vinblastine / Q000494:pharmacology
chemical_list: D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D002352:Carrier Proteins; D014747:Vinblastine; D016572:Cyclosporine; D006854:Hydrocortisone; D016559:Tacrolimus