[Hamartoma of the sebaceous follicle. An immunohistologic analysis with cytokeratins].
A 62-year-old man presented with a nodule 2 cm in diameter on his left cheek, which he had had since childhood. Histological examination showed a circumscribed dermal nodule composed of sebaceous lobules attached to sebaceous ducts and to an infundibular cyst-like structure connected to the epidermis. The wall was lined with squamous epithelium with a stratum granulosum. This structure was reminiscent of a sebaceous follicle. In addition, a melanocytic naevus of the compound type was found. Immunohistological investigations of the tumour with various cytokeratins revealed a pattern of expression characteristic for the mature sebaceous follicle.
Schirren
C G
CG
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, München.
Sander
C
C
Schirren
H
H
Lindner
A
A
Kind
P
P
Plewig
G
G
D014408:Biomarkers, Tumor / Q000032:analysis*; D002610:Cheek / Q000473:pathology; D003937:Diagnosis, Differential; D004814:Epidermal Cyst / Q000473:pathology*; D005148:Facial Dermatoses / Q000473:pathology*; D006222:Hamartoma / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007633:Keratins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D012627:Sebaceous Glands / Q000473:pathology*; D012867:Skin / Q000473:pathology
D014408:Biomarkers, Tumor; D007633:Keratins