title: Salicylaldoxime blocks K+ and Ca2+ currents in rat cardiac myocytes.
abstract: The effects of salicylaldoxime, 2-(OH)C6H4CH = NOH, on the action potential duration, transient outward K+ current and slow inward Ca2+ current were studied in isolated rat ventricular myocytes. The application of salicylaldoxime (0.1-2.0 mM) reversibly increased the action potential duration and reduced in a dose-dependent manner both the transient outward K+ and the slow inward Ca2+ currents. The effect of salicylaldoxime on these two ionic currents was similar to that of 2,3-butanedione monoxime, but was about ten times more potent. Compounds which block both K+ and Ca2+ currents may represent a new type of Class III antiarrhythmic agent which counteracts arrhythmias initiated by re-entry with reduced proarrhythmic risk via triggered activity.
authors.affiliation: Department of Physiology, University of Oulu, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Karhu
authors.forename: S
authors.initials: S
authors.lastname: Perttula
authors.forename: M
authors.initials: M
authors.lastname: Weckström
authors.forename: T
authors.initials: T
authors.lastname: Kivistö
authors.forename: L C
authors.initials: LC
authors.lastname: Sellin
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000494:pharmacology; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006321:Heart / Q000187:drug effects*; D009206:Myocardium / Q000166:cytology; D010091:Oximes / Q000494:pharmacology*; D026902:Potassium Channel Blockers; D051381:Rats
chemical_list: D000889:Anti-Arrhythmia Agents; D002121:Calcium Channel Blockers; D010091:Oximes; D026902:Potassium Channel Blockers; C005704:salicylaldoxime