Inhibition by sodium nitroprusside of the expression of inducible nitric oxide synthase in rat neutrophils.
A well-known nitric oxide (NO)-releasing compound, sodium nitroprusside (SNP), decreases in a dose-dependent manner NO synthase (NOS) activity induced in rat neutrophils by treatment with lipopolysaccharide (LPS). This inhibitory action of SNP seems not to be due to its direct effect on the enzyme activity. The strong nitrosonium ion (NO+) character of SNP could be responsible for its inhibition of NOS induction in neutrophils.
Mariotto
S
S
Istituto di Chimica Biologica, Università di Verona, Italy.
Cuzzolin
L
L
Adami
A
A
Del Soldato
P
P
Suzuki
H
H
Benoni
G
G
D000594:Amino Acid Oxidoreductases / Q000096:biosynthesis*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008070:Lipopolysaccharides / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology; D019001:Nitric Oxide Synthase; D009599:Nitroprusside / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
D008070:Lipopolysaccharides; D009599:Nitroprusside; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases