Low-dose iloprost infusion improves insulin action in aged healthy subjects and NIDDM patients.
OBJECTIVE
To investigate the effect of iloprost infusion on insulin action.


METHODS
Thirteen healthy subjects and 13 non-insulin-dependent diabetes mellitus (NIDDM) patients matched for age (68.2 +/- 0.5 vs. 67.9 +/- 0.5 years, NS), gender ratio (7 men:6 women vs. 6 men:7 women), body weight, body fat distribution, arterial blood pressure, and plasma triglyceride levels (1.89 +/- 0.09 vs. 1.87 +/- 0.08 mmol/l, NS) were studied. In eight healthy subjects and eight NIDDM patients, we studied insulin action by euglycemic glucose clamp (insulin infusion rate 2 mU.kg-1.min-1) along with saline and iloprost delivery (0.7 ng.kg-1.min-1). In the other five subjects of each group, forearm blood flow and insulin-mediated glucose uptake during saline and iloprost infusion (0.7 ng.kg-1.min-1) were investigated.


RESULTS
Iloprost infusion improved insulin-stimulated whole-body glucose uptake and oxidative and nonoxidative glucose metabolism in both study groups. Forearm blood flow under basal conditions and with insulin infusion (2 mU.kg-1.min-1) did not show any significant difference from that during saline and iloprost infusion (0.7 ng.kg-1.min-1) in healthy subjects and diabetic patients.


CONCLUSIONS
Iloprost infusion improves insulin action in healthy subjects and NIDDM patients.
Paolisso
G
G
Department of Geriatric Medicine and Metabolic Diseases II, University of Naples, Italy.
Di Maro
G
G
D'Amore
A
A
Passariello
N
N
Gambardella
A
A
Varricchio
M
M
D'Onofrio
F
F
D000368:Aged; D001786:Blood Glucose / Q000187:drug effects / Q000378:metabolism*; D001794:Blood Pressure / Q000187:drug effects*; D016022:Case-Control Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood / Q000503:physiopathology*; D003971:Diastole / Q000187:drug effects; D004347:Drug Interactions; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D016285:Iloprost / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007262:Infusions, Intravenous; D007328:Insulin / Q000097:blood / Q000494:pharmacology* / Q000627:therapeutic use; D007700:Kinetics; D008297:Male; D018482:Muscle, Skeletal / Q000098:blood supply*; D012016:Reference Values; D012039:Regional Blood Flow / Q000187:drug effects; D013599:Systole / Q000187:drug effects
D001786:Blood Glucose; D007328:Insulin; D016285:Iloprost