Significance of chromosome 1p loss of heterozygosity in neuroblastoma.
We analyzed 156 primary neuroblastoma tumor samples for loss of heterozygosity at the distal short arm of chromosome 1 (1p LOH). We also compared 1p LOH with known clinical and genetic prognostic variables as well as patient outcome. 1p LOH was detected in 30 of 156 tumors (19%) and was strongly associated with adverse clinical and biological features. 1p LOH was also strongly predictive of a poor outcome in univariate analyses (estimated 4-year survival, 32 +/- 10% SE versus 76 +/- 5% SE; P < 0.001). However, the prognostic value of 1p LOH was equivocal when stratified for amplification of the MYCN oncogene (P = 0.16). We conclude that 1p LOH is an important component of a pattern of genetic abnormalities in neuroblastoma associated with an aggressive clinical course.
Maris
J M
JM
Division of Oncology, Children's Hospital of Philadelphia, University of Pennsylvania, Philadepphia School of Medicine 19104, USA.
White
P S
PS
Beltinger
C P
CP
Sulman
E P
EP
Castleberry
R P
RP
Shuster
J J
JJ
Look
A T
AT
Brodeur
G M
GM
D000310:Adrenal Gland Neoplasms / Q000175:diagnosis / Q000235:genetics*; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002878:Chromosomes, Human, Pair 1; D005260:Female; D005784:Gene Amplification; D016259:Genes, myc; D005819:Genetic Markers; D006801:Humans; D007223:Infant; D008297:Male; D009447:Neuroblastoma / Q000175:diagnosis / Q000235:genetics*; D011379:Prognosis; D017384:Sequence Deletion
D005819:Genetic Markers