Ke 6 gene. Sequence and organization and aberrant regulation in murine polycystic kidney disease.
Ke 6 gene is a newly identified gene located in the major histocompatibility complex and is a candidate steroid dehydrogenase gene because of structural homology and regulatory similarities with mammalian steroid dehydrogenases. We report here the complete nucleotide sequence and intron-exon organization of the Ke 6 gene and cloning of the alternatively spliced Ke 6b transcript. We find that Ke 6 gene expression is down-regulated in pcy mice which is a murine model of polycystic kidney disease (PKD). Thus far, Ke 6 gene expression is down-regulated in all murine models of PKD we have examined. Abnormal steroid metabolism as a possible cause of PKD is discussed.
Maxwell
M M
MM
Department of Medicine, Children's Hospital, Boston, Massachusetts 02115, USA.
Nearing
J
J
Aziz
N
N
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D015536:Down-Regulation; D005260:Female; D005786:Gene Expression Regulation; D006649:Histocompatibility Antigens / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D010088:Oxidoreductases; D007690:Polycystic Kidney Diseases / Q000235:genetics* / Q000378:metabolism; D011401:Promoter Regions, Genetic; D013256:Steroids / Q000378:metabolism; D014158:Transcription, Genetic
C079876:H2-Ke6 protein, mouse; D006649:Histocompatibility Antigens; D013256:Steroids; D010088:Oxidoreductases