Treatment of hyperthermia and dehydration with hypertonic saline in dextran.
Hyperthermia may be accompanied by dehydration with or without electrolyte loss. To determine the efficacy of hypertonic saline in dextran solution (HSD, 7.5% NaCl in 6% dextran 70) for the treatment of heat stroke, rats were deprived of water for 24 h (DE) or not (ND), and then they were heat-stressed, and 4 mL/kg of saline (SAL) or HSD was administered via jugular cannula at the end of heat stress (a core temperature of 42.3 degrees C). The following four groups of 10 rats (Wistar-Furth) were used: NDSAL, DESAL, NDHSD, and DEHSD. Four control groups not subjected to heat stress were also studied. Percent change in plasma volume (PV) from baseline was significantly decreased by DE vs. ND (-6.8 +/- 1.2 vs. +4.6 +/- 1.6%) and increased by HSD vs. SAL (+10.1 +/- 4.1 vs. -3.5 +/- 1.6%) administration. Rats that were DE had significantly higher heating rates and less water loss during heat than ND rats, but hydration status was not correlated to 24 h survival. HSD groups had significantly higher PV and survival rates than their corresponding SAL groups regardless of hydrational status.
Matthew
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United States Army Research Institute of Environmental Medicine, Natick, Massachusetts 01760-5007, USA.
D000818:Animals; D001810:Blood Volume; D003643:Death; D003681:Dehydration / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D003911:Dextrans; D005334:Fever / Q000097:blood / Q000503:physiopathology / Q000628:therapy*; D006400:Hematocrit; D006358:Hot Temperature; D008297:Male; D051381:Rats; D011920:Rats, Inbred WF; D012462:Saline Solution, Hypertonic / Q000627:therapeutic use*; D013997:Time Factors; D015431:Weight Loss
D003911:Dextrans; D012462:Saline Solution, Hypertonic