title: Effects of juvenile hormone analogues (JHA) on the development of Trypanosoma cruzi.
abstract: Juvenile hormone analogues were tested for their lytic activity on Trypanosoma cruzi Chagas, 1909 blood tripomastigotes cultivated in vitro. The results indicated that the carbamate 4 and the phenoxyphenol derivative 1 are considered good candidates for blood sterilization. The compounds were also assayed for inhibition of development of parasites in infected mice showing a moderated degree of activity.
authors.affiliation: Instituto Nacional de Chagas, Buenos Aires, Argentina.
authors.forename: L
authors.initials: L
authors.lastname: Fichera
authors.forename: M
authors.initials: M
authors.lastname: Esteva
authors.forename: Z
authors.initials: Z
authors.lastname: Wimmer
authors.forename: J B
authors.initials: JB
authors.lastname: Rodriguez
authors.forename: E G
authors.initials: EG
authors.lastname: Gros
mesh_terms: D000818:Animals; D002219:Carbamates / Q000494:pharmacology; D014355:Chagas Disease / Q000188:drug therapy*; D007605:Juvenile Hormones / Q000494:pharmacology* / Q000627:therapeutic use*; D051379:Mice; D010636:Phenols / Q000494:pharmacology; D013329:Structure-Activity Relationship; D014344:Trypanocidal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D014349:Trypanosoma cruzi / Q000187:drug effects / Q000254:growth & development*
chemical_list: D002219:Carbamates; D007605:Juvenile Hormones; D010636:Phenols; D014344:Trypanocidal Agents