title: Continuous subcutaneous insulin infusion (CSII) in children and adolescents with chronic poorly controlled type 1 diabetes mellitus.
abstract: This study was undertaken to determine if continuous subcutaneous insulin infusion (CSII) could improve control, diminish episodes of diabetic ketoacidosis (DKA), decrease number of hospitalizations and save health care expenditure in children and adolescents with long-standing poorly controlled diabetes mellitus. A retrospective analysis was done of six patients with type 1 diabetes for 1-8 years, of whom 4 were non-adherent to the diabetic regimen (ages 12-16.5 years) and 2 of whom had brittle diabetes (ages 8.5 and 10 years). These patients were non-randomly placed on the MiniMed (Sylmar, CA) CSII system. The year prior to CSII was compared with the year during pump use. Glycoslyated hemoglobin (HbA1c), spot urinary microalbumin, total cholesterol, insulin dose, growth velocity, number of convulsions and hypoglycemic events, number of episodes of DKA, number of hospitalizations and total inpatient costs were compared for the 2 years. The year prior to CSII, mean HbA1c was 9.02% (S.D. = 0.86%), mean number of hospitalizations was 5.2/patient (S.D. = 4.6), mean number of hospital days was 20.8/patient (S.D. = 14.7) and mean cost was $29330/patient (S.D. = $22804). During 1 year of CSII, mean number of hospital days decreased to 5 days/patient (S.D. = 0.8, P = 0.016), mean number of hospitalizations (including DKA and pump initiation) decreased to 1.7/patient (S.D. = 0.7, P = 0.31), mean inpatient costs decreased to $12762/patient (S.D. = $5.950, P = 0.047). HbA1c, urinary microalbumin, cholesterol, insulin dose and growth velocity did not change in a statistically significant manner.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pediatrics, University of Southern California School of Medicine, Childrens Hospital, Los Angeles 90054-0700, USA.
authors.forename: B S
authors.initials: BS
authors.lastname: Steindel
authors.forename: T R
authors.initials: TR
authors.lastname: Roe
authors.forename: G
authors.initials: G
authors.lastname: Costin
authors.forename: M
authors.initials: M
authors.lastname: Carlson
authors.forename: F R
authors.initials: FR
authors.lastname: Kaufman
mesh_terms: D000293:Adolescent; D000419:Albuminuria; D002648:Child; D002784:Cholesterol / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D016883:Diabetic Ketoacidosis / Q000453:epidemiology; D006442:Glycated Hemoglobin / Q000032:analysis; D006128:Growth; D006760:Hospitalization; D006801:Humans; D007332:Insulin Infusion Systems; D007902:Length of Stay; D012189:Retrospective Studies; D012640:Seizures / Q000453:epidemiology / Q000517:prevention & control
chemical_list: D002784:Cholesterol; D006442:Glycated Hemoglobin