Expression of adhesion molecule ICAM-1 (CD54) in thyroid papillary adenocarcinoma.
The expression of adhesion molecules in thyroid specimens from 10 cases of papillary adenocarcinoma, 5 cases of follicular adenoma and 3 normal thyroid specimens was examined by an immunohistochemical method. Thyroid epithelial cells from all cases of papillary adenocarcinoma expressed the intercellular adhesion molecule 1 (ICAM-1, CD54). The ICAM-1-positive staining in these was detected predominantly on the apical site of malignant thyroid epithelial cells. However, no ICAM-1 expression was detected on thyrocytes of adenoma, and normal thyroid tissues. Furthermore, thyroid epithelial cells in patients with thyroid tumor and normal thyroid tissue did not react with anti-LFA-1, anti-VLA-4, anti-VCAM-1 and anti-ELAM-1 monoclonal antibodies. It is speculated that ICAM-1 expression in thyroid papillary adenocarcinoma may have a functional significance.
Nakashima
M
M
First Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
Eguchi
K
K
Ishikawa
N
N
Yamashita
I
I
Sakai
M
M
Ida
H
H
Kawabe
Y
Y
Ito
K
K
Nagataki
S
S
D018263:Adenocarcinoma, Follicular / Q000737:chemistry / Q000473:pathology; D000231:Adenocarcinoma, Papillary / Q000737:chemistry* / Q000473:pathology; D000236:Adenoma / Q000737:chemistry / Q000473:pathology; D000911:Antibodies, Monoclonal / Q000032:analysis / Q000276:immunology; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000276:immunology; D019040:E-Selectin; D004848:Epithelium / Q000737:chemistry / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D018799:Intercellular Adhesion Molecule-1 / Q000032:analysis* / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000032:analysis / Q000276:immunology; D016029:Receptors, Very Late Antigen / Q000032:analysis / Q000276:immunology; D013961:Thyroid Gland / Q000737:chemistry / Q000166:cytology / Q000473:pathology; D013964:Thyroid Neoplasms / Q000737:chemistry* / Q000473:pathology; D019010:Vascular Cell Adhesion Molecule-1
D000911:Antibodies, Monoclonal; D015815:Cell Adhesion Molecules; D019040:E-Selectin; D016169:Lymphocyte Function-Associated Antigen-1; D016029:Receptors, Very Late Antigen; D019010:Vascular Cell Adhesion Molecule-1; D018799:Intercellular Adhesion Molecule-1