title: Peripheral blood reduction of memory (CD29+, CD45RO+, and "bright" CD2+ and LFA-1+) T lymphocytes in Papillon-Lefèvre syndrome.
abstract: A Papillon-Lefèvre patient with characteristic chronic periodontal disease and palmoplantar keratoderma was studied over a 4-year period. An abnormal T-cell phenotype was steadily observed in peripheral blood; both low numbers of CD29+ and CD45RO+ cells and a low density surface expression of CD2 and LFA-1 molecules were found. T-cell activation through CD3, CD2 and ConA, PWM and IL-2 receptors was normal; however, there was impairment in the activation via CD28. CD2, LFA-1 and CD45 molecules were normal in charge and molecular weight. There was no tissue sequestering of T lymphocytes in periodontal lesions, but rather a relative T-cell reduction. It is suggested that an important decrease of the so-called "memory/hyperreactive" (CD45RO-positive) T cells does exist; therefore, hyperreactive T cells would not be available in sufficient numbers to leave the bloodstream through blood vessel endothelium, and the periodontium would be left without these important defenses and thus exposed to chronic infections. A disregulated factor affecting the transition from "naive" to "memory" T cells and the increase in certain surface molecules expression (i.e., CD2, LFA-1, CD29, and CD45RO) or the reversion from memory to naive T cells may be responsible for the disease pathogenesis. CD2 and LFA-1 molecule synthesis might be conjointly regulated on T lymphocytes.
authors.affiliation: Department of Immunology, Hospital Universitario 12 de Octubre, Madrid, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Góngora
authors.forename: A
authors.initials: A
authors.lastname: Corell
authors.forename: J R
authors.initials: JR
authors.lastname: Regueiro
authors.forename: M
authors.initials: M
authors.lastname: Carasol
authors.forename: C
authors.initials: C
authors.lastname: Rodríguez-Gallego
authors.forename: E
authors.initials: E
authors.lastname: Paz-Artal
authors.forename: M
authors.initials: M
authors.lastname: Timón
authors.forename: L
authors.initials: L
authors.lastname: Allende
authors.forename: A
authors.initials: A
authors.lastname: Arnaiz-Villena
mesh_terms: D000293:Adolescent; D015703:Antigens, CD / Q000276:immunology*; D018801:CD2 Antigens / Q000276:immunology; D015815:Cell Adhesion Molecules / Q000276:immunology*; D002460:Cell Line; D004591:Electrophoresis, Polyacrylamide Gel; D006801:Humans; D007150:Immunohistochemistry; D007156:Immunologic Memory / Q000276:immunology*; D016130:Immunophenotyping; D019012:Integrin beta1; D016023:Integrins / Q000276:immunology; D007553:Isotope Labeling; D017493:Leukocyte Common Antigens / Q000276:immunology; D016169:Lymphocyte Function-Associated Antigen-1 / Q000276:immunology; D008297:Male; D010214:Papillon-Lefevre Disease / Q000276:immunology*; D011233:Precipitin Tests; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015703:Antigens, CD; D018801:CD2 Antigens; D015815:Cell Adhesion Molecules; D019012:Integrin beta1; D016023:Integrins; D016169:Lymphocyte Function-Associated Antigen-1; D017493:Leukocyte Common Antigens