Immunohistochemical evaluation of bone morphogenetic protein (BMP) in mixed tumor of skin.
Immunohistochemical reaction of bone morphogenetic protein (BMP) was assessed in 19 cases of skin mixed tumor and 5 cases of skin appendage tumors by using monoclonal antibody raised against BMP. All cases of skin mixed tumor showed positive staining for BMP in modified myoepithelial cells located at the periphery of tubulo-ductal or solid structures, and in plasmacytoid or tumor cells in hyalinous structures. Chondroidally changed cells also showed a strong BMP immunoreactivity. Tumors originating from sweat glands were devoid of BMP immunoreactivity. It is concluded that BMP is synthesized and produced in modified or transformed myoepithelial cells in skin mixed tumor and participates in the process of chondroid changes in the tumor.
Yang
L
L
Department of Oral Pathology, Stomatological College of the Fourth Military Medical University, Xian, People's Republic of China.
Nakamine
H
H
Kamegai
A
A
Sumitomo
S
S
Mori
M
M
D008949:Adenoma, Pleomorphic / Q000378:metabolism* / Q000473:pathology; D019485:Bone Morphogenetic Proteins; D002356:Cartilage / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry / Q000379:methods; D009363:Neoplasm Proteins / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D012878:Skin Neoplasms / Q000378:metabolism* / Q000473:pathology; D013194:Staining and Labeling
D019485:Bone Morphogenetic Proteins; D009363:Neoplasm Proteins; D011506:Proteins