title: Immunologically ignorant autoreactive T cells, epitope spreading and repertoire limitation.
abstract: The factors that may cause antigen-presenting cells to alter the pattern of protein processing and presentation to autoreactive T cells, and thereby stimulate autoimmune disease, are currently under debate. In this article, Chris Elson and colleagues suggest that cytokines associated with T helper 1 (Th1) cells alter the processing of proteins and that this effect can be counteracted by Th2-associated cytokines.
authors.affiliation: University of Bristol Dept of Pathology and Microbiology, UK.
authors.forename: C J
authors.initials: CJ
authors.lastname: Elson
authors.forename: R N
authors.initials: RN
authors.lastname: Barker
authors.forename: S J
authors.initials: SJ
authors.lastname: Thompson
authors.forename: N A
authors.initials: NA
authors.lastname: Williams
mesh_terms: D000818:Animals; D017951:Antigen Presentation / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D000939:Epitopes / Q000276:immunology*; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology*; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
chemical_list: D001324:Autoantigens; D000939:Epitopes