Fungal metabolites. XVIII. New membrane-modifying peptides, trichorozins I-IV, from the fungus Trichoderma harzianum.
New membrane-modifying peptides, trichorozins I-IV, have been isolated from conidia of the fungus Trichoderma harzianum. Their amino acid sequences were clearly determined by spectrometric methods and, furthermore, they were synthesized by the solution-phase method. Trichorozins are a family of the class of peptaibols and are composed of 11 residues including an amino alcohol. Trichorozins exhibited voltage-dependent ion channel-like activity in lipid bilayers.
Iida
A
A
Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
Sanekata
M
M
Wada
S
S
Fujita
T
T
Tanaka
H
H
Enoki
A
A
Fuse
G
G
Kanai
M
M
Asami
K
K
D000595:Amino Acid Sequence; D005656:Fungal Proteins / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects; D008051:Lipid Bilayers; D008565:Membrane Proteins / Q000187:drug effects; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014242:Trichoderma / Q000737:chemistry* / Q000378:metabolism*
D005656:Fungal Proteins; D007473:Ion Channels; D008051:Lipid Bilayers; D008565:Membrane Proteins; D009842:Oligopeptides