[Results of combined multicycle locoregional therapy in the palliative treatment of multiple liver metastases].
Twenty eight patients with multiple liver metastases were treated by locoregional intraarterial chemotherapy including 118 (3-7, mean 4.2) cycles. In the majority of patients the treatments were carried out in the form of combined cytostatic infusions into the hepatic artery using 5-FU, doxorubicin, cisplatin and mitomycin-C and were complemented by transcatheter embolisation, chemoembolisation and lipiodolisation. In some patients the lipiodolisation was choosen as the primary treatment. In patients with metastases from breast cancer (n = 11) 3 CR, 6 PR, 2 MR occured, the mean survival was 18.4 months, while the one- and two-year survival was 7/11 and 4/11, respectively. In the colorectal group (n = 10) 0 CR, 6 PR, 4 MR were achieved with a mean survival of 13.6 months; one-year survival was 5/10. In the third group (n = 7) consisting of also patients with the poorest prognosis a mean survival of 11.5 months (referring to 6/7 patients) could be accomplished. A patient with metastases from a retroperitoneal anaplastic carcinoma is still alive and disease-free for 92 months. Authors emphasise the importance and effectiveness of locoregional treatments in improving the quality of life as well as survival of patients with unresectable liver metastases.
Kónya
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Semmelweis Orvostudományi Egyetem, Radiológiai Klinika, Budapest.
Vigváry
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D000287:Administration, Topical; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage*; D001943:Breast Neoplasms / Q000473:pathology; D004621:Embolization, Therapeutic; D005260:Female; D006801:Humans; D006814:Hungary; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000556:secondary*; D008297:Male; D008875:Middle Aged; D010166:Palliative Care; D012186:Retroperitoneal Neoplasms / Q000473:pathology; D015996:Survival Rate