Colocalization of fructose-1,6-bisphosphatase and glial fibrillary acidic protein in rat brain.
Immunofluorescence studies of rat brain sections demonstrated an exclusive colocalization of the gluconeogenic key enzyme fructose-1,6-bisphosphatase (FBPase) with the astroglial marker glial fibrillary acidic protein, indicating FBPase in brain as an astrocyte-specific enzyme. This conclusion was supported by the presence of FBPase activity in astroglia-rich but not neuron-rich primary cultures derived from rat brain.
Schmoll
D
D
Physiologisch-chemisches Institut der Universität, Tübingen, Germany.
Cesar
M
M
Führmann
E
E
Hamprecht
B
B
D000818:Animals; D001253:Astrocytes / Q000737:chemistry* / Q000201:enzymology; D001923:Brain Chemistry; D002478:Cells, Cultured; D005455:Fluorescent Antibody Technique; D006597:Fructose-Bisphosphatase / Q000032:analysis*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis*; D051381:Rats
D005904:Glial Fibrillary Acidic Protein; D006597:Fructose-Bisphosphatase