Effect of felodipine on cholinergic responses of the colonic smooth muscle of streptozotocin induced diabetic rats.
In streptozotocin induced diabetic rats, irrespective of felodipine treatment (5 mg/kg/day po for 4 weeks), a reduction in contractile response of colonic smooth muscle in vitro was observed. Similarly, in both control and diabetic rats treated with felodipine, contractile response was reduced. However, in felodipine treated diabetic rats there was a significant increase in response to exogenous acetylcholine. It may be of interest to study the effect of felodipine, on gastro-intestinal motility in vivo in diabetic rats, to enable extrapolation of the present results to the effect of felodipine on gastrointestinal complications of diabetes mellitus.
Jaiprakash
R
R
Department of Pharmacology, St. John's Medical College, Bangalore, India.
Rani
M A
MA
Venkataraman
B V
BV
Andrade
C
C
D000109:Acetylcholine / Q000502:physiology*; D000818:Animals; D003106:Colon / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D015736:Felodipine / Q000494:pharmacology*; D005260:Female; D008297:Male; D009130:Muscle, Smooth / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar
D000109:Acetylcholine; D015736:Felodipine