title: [Heart rupture in the acute period of myocardial infarction: prognostication and ways of prevention].
abstract: Clinical, instrumental, and biochemical examinations were carried out in 587 patients with transmural myocardial infarctions (381 patients with the first infarction and 206 ones with the repeated disease). Heart ruptures occurred in 5.7% of cases. Clinical forms and risk factors of heart rupture are described. Another group consisted of 815 patients with the first transmural infarction; in 44 patients at a high risk of heart ruptures preventive therapy with pantripin and contrykal was carried out. The incidence of heart ruptures was reduced twofold in this group as against the controls. Heart rupture risk factors in patients with myocardial infarction are described. The syndrome of excessive resorption in the pre-rupture period of myocardial infarction was singled out, manifesting by increased activities of lactate dehydrogenase, lysosomal enzymes, and elevated level of cardiac antigen. Lysosomal enzyme levels were measured in the myocardium in heart ruptures. The authors have defined the notion of 'mechanical incompetence' in myocardial infarction, consisting in inability of the involved myocardium to resist the intraventricular blood pressure. The program of heart rupture prevention in myocardial infarction is presented.
authors.forename: G A
authors.initials: GA
authors.lastname: Trofimov
authors.forename: V N
authors.initials: VN
authors.lastname: Ardashev
authors.forename: L S
authors.initials: LS
authors.lastname: Serova
authors.forename: A S
authors.initials: AS
authors.lastname: Vershinin
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Baranovskiĭ
authors.forename: A V
authors.initials: AV
authors.lastname: Babaĭtsev
authors.forename: P P
authors.initials: PP
authors.lastname: Minin
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000933:Antifibrinolytic Agents / Q000627:therapeutic use; D007611:Aprotinin / Q000627:therapeutic use; D004796:Clinical Enzyme Tests; D005260:Female; D006342:Heart Rupture, Post-Infarction / Q000175:diagnosis / Q000517:prevention & control; D006801:Humans; D008247:Lysosomes / Q000201:enzymology; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000627:therapeutic use; D011379:Prognosis; D011480:Protease Inhibitors / Q000627:therapeutic use
chemical_list: D000933:Antifibrinolytic Agents; D010455:Peptides; D011480:Protease Inhibitors; C003041:pantripin; D007611:Aprotinin