title: Oral intake of selenium has no effect on the serum concentrations of growth hormone, insulin-like growth factor-1, insulin-like growth factor-binding proteins 1 and 3 in healthy women.
abstract: The administration of large doses of selenium (Se) to rats leads to reduced serum levels of somatotropin (growth hormone) and insulin-like growth factor-1 (IGF-1), followed by growth retardation. Similar experiments in humans have been contradictory. The effects of wheat Se and selenomethionine supplementation were investigated in healthy, Norwegian women. In study 1, the participants (n = 18) were given Se-rich bread with 100, 200 and 300 micrograms Se daily for 6 weeks. Initial serum Se concentration were 1.5 +/- 0.2 mumol/l (mean +/- SD). Serum Se increased in a dose-dependent manner in the three groups (p < 0.001). There was no effect on somatotropin and IGF-1 at any of the Se doses given. In study 2 (n = 24), the effects of 400 micrograms selenomethionine daily for 15 weeks were studied in a placebo controlled study. In the treatment group, serum Se concentrations increased by more than 100%. There was, however, no effect on serum somatotropin and IGF-1 concentrations, nor was there any effect on IGF-binding proteins 1 and 3. Our results indicate that at normal or slightly increased intakes, Se has no effect on the serum concentrations of these two hormones in healthy individuals.
authors.affiliation: University of Oslo, Nordic School of Nutrition, Faculty of Medicine, Blindern, Norway.
authors.forename: H M
authors.initials: HM
authors.lastname: Meltzer
authors.forename: E
authors.initials: E
authors.lastname: Haug
mesh_terms: D000328:Adult; D000818:Animals; D005260:Female; D005527:Food, Fortified; D013006:Growth Hormone / Q000097:blood* / Q000187:drug effects; D006801:Humans; D018970:Insulin-Like Growth Factor Binding Protein 1 / Q000097:blood* / Q000187:drug effects; D018972:Insulin-Like Growth Factor Binding Protein 3 / Q000097:blood* / Q000187:drug effects; D007334:Insulin-Like Growth Factor I / Q000032:analysis / Q000187:drug effects / Q000378:metabolism*; D010919:Placebos; D051381:Rats; D012643:Selenium / Q000008:administration & dosage / Q000494:pharmacology*; D012645:Selenomethionine / Q000008:administration & dosage / Q000494:pharmacology*; D014908:Triticum
chemical_list: D018970:Insulin-Like Growth Factor Binding Protein 1; D018972:Insulin-Like Growth Factor Binding Protein 3; D010919:Placebos; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D012645:Selenomethionine; D012643:Selenium