Effect of RANTES on eosinophil adhesion to plates coated with recombinant soluble intercellular adhesion molecule-1 and expression of beta 2-integrin adhesion molecules on eosinophils.
RANTES, a member of the 8-kDa cytokine family, has been shown to possess chemotactic activity for eosinophils. In this study, RANTES augmented isolated human eosinophil adhesion to plates coated with recombinant soluble intercellular adhesion molecule 1. In addition, RANTES did not augment the expression of beta 2-integrin adhesion molecules (lymphocyte function associated antigen-1 alpha (LFA-1 alpha), LFA-1 beta, complement receptor type 3 (CR3)) on human eosinophils. These findings suggest that RANTES not only modulates the chemotactic activity of eosinophils but also intensifies the function of eosinophil adhesion without augmenting the expression of beta 2-integrin adhesion molecules.
Kakazu
T
T
Fourth Department of Internal Medicine, Kinki University, Osaka, Japan.
Chihara
J
J
Saito
A
A
Nakajima
S
S
D001249:Asthma / Q000473:pathology; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000494:pharmacology*; D002478:Cells, Cultured; D018946:Chemokine CCL5 / Q000494:pharmacology*; D004804:Eosinophils / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D016023:Integrins / Q000378:metabolism*; D018799:Intercellular Adhesion Molecule-1 / Q000502:physiology*; D016024:Receptors, Cytoadhesin / Q000378:metabolism; D011994:Recombinant Proteins / Q000494:pharmacology
D015815:Cell Adhesion Molecules; D018946:Chemokine CCL5; D016023:Integrins; D016024:Receptors, Cytoadhesin; D011994:Recombinant Proteins; D018799:Intercellular Adhesion Molecule-1