[Bone marrow granular-cell tumor with histological and immunohistochemical analysis: 1st case in the literature].
Here is described a rare case of a tumour with granular cells, placed in the bone marrow (radius bone) which caused a spontaneous fracture. The tumour has answered positivity to the immuno-histochemical SP 100 and NSE tests. Besides, wide focusing of moderate dysplasia of the granular cells were found, which answered partly in histochemical tests NSE and PS 100. There has been analysed the literature on multi-visceral incidence of this tumoral histotype and on its histogenesis. On the basis of the heterogeneous nature of this tumor, it was thought the name of tumour with granular cells to be more appropriate than myoblastoma.
Linoli
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U.O. di Anatomia e Istologia Patologica e di Citogenetica, Presidio Ospedaliero, USL 23, Arezzo.
D001399:Azure Stains; D014408:Biomarkers, Tumor / Q000032:analysis*; D001855:Bone Marrow Diseases / Q000473:pathology*; D001859:Bone Neoplasms / Q000737:chemistry / Q000150:complications / Q000473:pathology*; D005260:Female; D005598:Fractures, Spontaneous / Q000209:etiology; D016586:Granular Cell Tumor / Q000737:chemistry / Q000150:complications / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000032:analysis*; D010503:Periodic Acid-Schiff Reaction; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D011884:Radius / Q000473:pathology*; D011885:Radius Fractures / Q000209:etiology; D009418:S100 Proteins / Q000032:analysis; D016622:Silver Staining; D013194:Staining and Labeling; D000514:alpha 1-Antichymotrypsin / Q000032:analysis
D001399:Azure Stains; D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; D009418:S100 Proteins; D000514:alpha 1-Antichymotrypsin; D010751:Phosphopyruvate Hydratase