[Neuron specific enolase-producing IgD multiple myeloma with high serum amylase activity].
A 68-year-old man who was admitted to our hospital because of general fatigue and anorexia. He was diagnosed as suffering from neuron specific enolase (NSE)-producing IgD-lambda type multiple myeloma with high activity of serum amylase, based on the detection of monoclonal IgD-lambda M-protein in the serum and urine, markedly high activities of salivary-type amylase and NSE in the serum, and immunohistochemical evidence of NSE and IgD in the myeloma cells. After two courses of alpha-IFN and VMCP chemotherapy, serum IgD, amylase and NSE decreased to normal levels. These observations indicate that NSE was ectopically produced by myeloma cells.
Nakajima
T
T
Japan Research Foundation for Chronic Diseases and Rehabilitation Affilated Hospital, Sakuragaoka Hospital.
Noguchi
T
T
Kumahara
Y
Y
Sugihara
A
A
Yamazaki
T
T
Iwasaki
T
T
Hamano
T
T
Kakishita
E
E
D000368:Aged; D000681:Amylases / Q000097:blood*; D006801:Humans; D007072:Immunoglobulin D / Q000032:analysis*; D007145:Immunoglobulin kappa-Chains / Q000032:analysis*; D008297:Male; D009101:Multiple Myeloma / Q000201:enzymology*; D010751:Phosphopyruvate Hydratase / Q000096:biosynthesis*
D007072:Immunoglobulin D; D007145:Immunoglobulin kappa-Chains; D000681:Amylases; D010751:Phosphopyruvate Hydratase