[Use of serotonin adipinate in acute oral poisoning].
Ninety-five patients with acute poisonings with psychotropic agents, barbiturates, amitriptyline, leponex, cholinolytics, and organophosphorus insecticides were treated by gastro-enteroadsorption making use of activated coal. In order to enhance propulsive function of the gastrointestinal tract, serotonin adipinate was repeatedly administered in a dose of 5 to 20 mg. Evacuation of the enteroadsorbent in the rectum was enhanced fivefold in comparison with a control group of similar patients administered traditional drugs (proserine, pituitrin, cerucal). As a result of such therapy, the toxicogenic phase of poisoning was shortened and mortality in the observed group reduced twofold in patients poisoned with psychotropic agents, 5.4 times in those with barbiturate poisoning, and 3.5 times in those with organophosphorus poisoning.
Matkevich
V A
VA
Simonenkov
A P
AP
Ostapenko
Iu N
IuN
Zavadovskiĭ
M M
MM
Drendel'
S D
SD
Kashtanova
I S
IS
D000272:Adipates / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000293:Adolescent; D000328:Adult; D000639:Amitriptyline / Q000506:poisoning; D001463:Barbiturates / Q000506:poisoning; D002606:Charcoal / Q000627:therapeutic use; D018680:Cholinergic Antagonists / Q000506:poisoning; D003024:Clozapine / Q000506:poisoning; D016061:Enterosorption; D005769:Gastrointestinal Motility / Q000187:drug effects; D006801:Humans; D007306:Insecticides / Q000506:poisoning; D008787:Metoclopramide / Q000627:therapeutic use; D008875:Middle Aged; D009388:Neostigmine / Q000627:therapeutic use; D009943:Organophosphorus Compounds; D010909:Pituitary Hormones, Posterior / Q000627:therapeutic use; D011041:Poisoning / Q000188:drug therapy* / Q000503:physiopathology / Q000628:therapy; D011619:Psychotropic Drugs / Q000506:poisoning; D012701:Serotonin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use
D000272:Adipates; D001463:Barbiturates; D018680:Cholinergic Antagonists; D007306:Insecticides; D009943:Organophosphorus Compounds; D010909:Pituitary Hormones, Posterior; D011619:Psychotropic Drugs; C059902:serotonin adipinate; D002606:Charcoal; D000639:Amitriptyline; D012701:Serotonin; D009388:Neostigmine; D003024:Clozapine; D008787:Metoclopramide