title: Charge dissociation and the rising phase of gating currents.
abstract: Gating currents from voltage-sensitive channels are generally attributed to the translocation or redistribution of ionic charge associated with the channel molecule. Such charge moves in the direction of the applied field to produce a decreasing current in the external circuit. An early rising phase for the gating current is observed for a number of channel systems and might be either some special kinetic redistribution of charge or an experimental artifact. A model that produces net charge in the channel through sequential molecular dissociation of a charged channel segment gives a rising phase for the gating current. Translocation of the charged segment produces the decay phase for a biphasic gating current. This kinetic molecular explanation constitutes a physical explanation for the biphasic gating currents that is consistent with present views of channel structure.
authors.affiliation: Department of Chemistry, State University of New York at Binghamton 13850, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Starzak
mesh_terms: D016477:Artifacts; D015640:Ion Channel Gating; D007473:Ion Channels / Q000502:physiology*; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological
chemical_list: D007473:Ion Channels