title: Consistent presence of isochromosome 7q in hepatosplenic T gamma/delta lymphoma: a new cytogenetic-clinicopathologic entity.
abstract: Peripheral T-cell lymphoma (PTL), which is characterized by hepatosplenic presentation and the gamma/delta T-cell receptor (TCR) phenotype on the malignant cells, is a rare but distinct subtype of non-Hodgkin's lymphomas. Little is known about the chromosomal changes in these lymphomas. We report the cytogenetic analysis of three patients who had neoplastic proliferation of T gamma/delta cells in the spleen, bone marrow, and liver, but not in lymph nodes or skin. Isochromosome 7q and trisomy 8 were observed in all three patients. Isochromosome 7q as the sole abnormality has been previously reported in one patient with similar clinicopathologic features. It is suggested that i(7q) is a primary, nonrandom chromosomal abnormality in hepatosplenic T gamma/delta PTL.
authors.affiliation: Department of Internal Medicine, National Taiwan University Hospital, Taipei, R.O.C.
authors.forename: C C
authors.initials: CC
authors.lastname: Wang
authors.forename: H F
authors.initials: HF
authors.lastname: Tien
authors.forename: M T
authors.initials: MT
authors.lastname: Lin
authors.forename: I J
authors.initials: IJ
authors.lastname: Su
authors.forename: C H
authors.initials: CH
authors.lastname: Wang
authors.forename: S M
authors.initials: SM
authors.lastname: Chuang
authors.forename: M C
authors.initials: MC
authors.lastname: Shen
authors.forename: C H
authors.initials: CH
authors.lastname: Liu
mesh_terms: D000328:Adult; D015703:Antigens, CD / Q000032:analysis; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D002897:Chromosomes, Human, Pair 7; D002898:Chromosomes, Human, Pair 8; D017809:Fatal Outcome; D005819:Genetic Markers; D006801:Humans; D018404:Isochromosomes; D008113:Liver Neoplasms / Q000235:genetics* / Q000276:immunology; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics* / Q000276:immunology; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis; D013154:Spleen / Q000276:immunology / Q000473:pathology; D013160:Splenic Neoplasms / Q000235:genetics* / Q000276:immunology; D014314:Trisomy
chemical_list: D015703:Antigens, CD; D005819:Genetic Markers; D016692:Receptors, Antigen, T-Cell, gamma-delta