title: Prostate-specific antigen levels in patients receiving long-term dialysis.
abstract: OBJECTIVE
  To investigate the effect, if any, of renal failure upon prostate-specific antigen (PSA) levels and the validity of PSA estimation as a marker of prostatic disease in renal failure.
  
  
  METHODS
  PSA was measured in 65 men (median age 67 years, range 39-84) on regular haemodialysis and 37 men (median age 70 years, range 42-77) on continuous ambulatory peritoneal dialysis (CAPD). Patients with a PSA level > 4 ng/mL underwent prostatic biopsy guided by transrectal ultrasonography.
  
  
  RESULTS
  There was no evidence of an artefactual elevation of PSA attributable solely to renal failure. All eight patients with a PSA level > 4 ng/mL had prostatic disease.
  
  
  CONCLUSIONS
  PSA measurements in patients with end-stage renal failure treated by dialysis remain a useful marker of prostatic disease.
authors.affiliation: Department of Nephrology, St Bartholomew's Hospital, London, UK.
authors.forename: L
authors.initials: L
authors.lastname: Harper
authors.forename: C W
authors.initials: CW
authors.lastname: McIntyre
authors.forename: I C
authors.initials: IC
authors.lastname: MacDougall
authors.forename: P
authors.initials: P
authors.lastname: Meyer
authors.forename: A E
authors.initials: AE
authors.lastname: Raine
authors.forename: L R
authors.initials: LR
authors.lastname: Baker
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood*; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D010531:Peritoneal Dialysis, Continuous Ambulatory; D017430:Prostate-Specific Antigen / Q000097:blood*; D011470:Prostatic Hyperplasia / Q000097:blood* / Q000175:diagnosis; D011471:Prostatic Neoplasms / Q000097:blood* / Q000175:diagnosis
chemical_list: D017430:Prostate-Specific Antigen