Clausenol and clausenine--two carbazole alkaloids from Clausena anisata.
Two new carbazole alkaloids, designated as clausenol and clausenine, were isolated from an alcoholic extract of the stem bark of Clausena anisata. Their structures were established as 1-hydroxy-6-methoxy-3-methylcarbazole and 1,6-dimethoxy-3-methyl carbazole, respectively, from physical and chemical evidence and synthesis. Clausenol was found to be active against Gram-positive and Gram-negative bacteria and fungi.
Chakraborty
A
A
Department of Chemistry, School of Tropical Medicine, Calcutta, India.
Chowdhury
B K
BK
Bhattacharyya
P
P
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D002227:Carbazoles / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects*; D006094:Gram-Positive Bacteria / Q000187:drug effects*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018547:Plant Stems; D010946:Plants, Medicinal; D013055:Spectrophotometry, Infrared
D000900:Anti-Bacterial Agents; D002227:Carbazoles; C096080:clausenine; C096079:clausenol