Assessment of Yqh translocations.
Two initially presumed Yqh translocations, one to Xp and another to 21p, were assessed by conventional banding procedures, 5-azacytidine treatment, electron microscopy, and fluorescence in situ hybridisation. While the Yqh nature of the heterochromatic block from Xp was confirmed, this was not the case with the 21ph+ variant. In conclusion, conventional banding techniques are insufficient to diagnose Y;G translocations.
Fernández
J L
JL
Centro Oncológico de Galicia, Laboratorio de Genética, La Coruña, Spain.
Pereira
S
S
Campos
A
A
Goyanes
V
V
D001374:Azacitidine; D002891:Chromosomes, Human, Pair 21; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008297:Male; D008854:Microscopy, Electron; D014178:Translocation, Genetic; D014960:X Chromosome; D014998:Y Chromosome
D001374:Azacitidine