[Interference of selenium germanium and calcium in carcinogenesis of colon cancer].
We studied DMH induced colon cancer in 120 wistar rats, which were divided into 8 groups based on different diets. They were killed and autopsied on 4 weeks after the last injection of DMH. The tumors in various organs including its characteristics, number, site, histological types and ultrastructural changes were observed. The results showed that high fat diet has a significant effect on DMH induced colon cancer. Selenium and calcium can inhibit the effect of DMH and decrease the incidence of colon cancer. Selenium can also interfere the effect of high fat diet but germanium has no effect on colon carcinogenesis.
Yu
B
B
Ruijin Hospital, Shanghai Second Medical University.
Wu
J
J
Zhou
X
X
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology; D002118:Calcium / Q000494:pharmacology*; D002273:Carcinogens; D002291:Carcinoma, Papillary / Q000139:chemically induced / Q000517:prevention & control*; D003110:Colonic Neoplasms / Q000139:chemically induced / Q000517:prevention & control*; D004041:Dietary Fats / Q000009:adverse effects; D004127:Dimethylhydrazines; D005857:Germanium; D008297:Male; D009942:Organometallic Compounds / Q000494:pharmacology; D011422:Propionates; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000494:pharmacology*
D000970:Antineoplastic Agents; D002273:Carcinogens; D004041:Dietary Fats; D004127:Dimethylhydrazines; D009942:Organometallic Compounds; D011422:Propionates; D005857:Germanium; C066750:propagermanium; D012643:Selenium; D002118:Calcium