The death domain motif found in Fas (Apo-1) and TNF receptor is present in proteins involved in apoptosis and axonal guidance.
The interaction of Fas (Apo-1) and TNF receptor-1 with their respective ligands can lead to cell death. The so-called death domain, a sequence motif present in the cytoplasmic portion of the two receptors, has been identified as a critical structural element involved in signal transduction that leads to apoptosis. Here we describe several additional proteins which contain a death domain. Novel members of this family include proteins known to be implicated not only in apoptosis but also in neuron guidance.
Hofmann
K
K
Swiss Institute for Cancer Research, University of Lausanne, Epalinges, Switzerland.
Tschopp
J
J
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis; D001369:Axons; D001483:Base Sequence; D001665:Binding Sites; D002465:Cell Movement; D016208:Databases, Factual; D006801:Humans; D008969:Molecular Sequence Data; D018124:Receptors, Tumor Necrosis Factor / Q000378:metabolism*; D019014:fas Receptor / Q000378:metabolism*
D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor