[A long-term course of experimentally produced choroidal neovascularization in the rat].
We studied morphologically a long-term course of experimental choroidal neovascularization (ChNV) induced by krypton laser photocoagulation in the rat retina. Fifty-two weeks after photocoagulation, ChNV was enveloped completely by the retinal pigment epithelium. Vascular endothelial cells of ChNV were thin, with many fenestrations and wide lumen. The ChNV maintained the morphological characteristics of mature leaky capillaries similar to choriocapillaris. The lumen of the neovascularizations tended to be compressed by massive collagen fibers produced by the retinal pigmented epithelium. We found that experimental ChNV in the rat retina retains the characteristics of leaky capillaries for a long time unlike that in the monkey ChNV.
Tobe
T
T
Department of Ophthalmology, Kansai Medical University, Osaka-fu, Japan.
Takahashi
K
K
Ohkuma
H
H
Uyama
M
M
D000818:Animals; D002829:Choroid / Q000098:blood supply*; D004730:Endothelium, Vascular / Q000648:ultrastructure; D017075:Laser Coagulation; D008854:Microscopy, Electron; D009389:Neovascularization, Pathologic / Q000473:pathology*; D010857:Pigment Epithelium of Eye / Q000648:ultrastructure; D051381:Rats; D011914:Rats, Inbred BN