Absence of a pharmacokinetic interaction between quinidine and diazepam.
Influence of diazepam on the pharmacokinetics of quinidine was studied in eight healthy human volunteers by administering 250 mg of quinidine sulphate either alone or in combination with 10 mg diazepam in a cross-over study. Quinidine in the biological samples was estimated fluorimetrically. Comparison of various pharmacokinetic parameters of quinidine (Cmax 2.165 +/- 0.457 vs 2.239 +/- 0.338 micrograms/ml, Tmax 2 +/- 0.71 vs 2.13 +/- 0.58 h, T1/2 7.004 +/- 1.302 vs 7.82 +/- 1.63 h, Cls/f 153.63 +/- 45.65 vs 134.87 +/- 31 ml/h/kg, AUC0-alpha 22.131 +/- 6.118 vs 24.321 +/- 4.924 micrograms.h/ml) by means of a two tailed t-test revealed no significant (p > 0.05) effect of diazepam on quinidine disposition kinetics.
Rao
B R
BR
University College of Pharmaceutical Sciences, Kakatiya University, Warangal, India.
Rambhau
D
D
D000293:Adolescent; D000328:Adult; D000889:Anti-Arrhythmia Agents / Q000493:pharmacokinetics* / Q000494:pharmacology*; D001682:Biological Availability; D018592:Cross-Over Studies; D003975:Diazepam / Q000493:pharmacokinetics* / Q000494:pharmacology*; D004347:Drug Interactions; D006207:Half-Life; D006801:Humans; D006993:Hypnotics and Sedatives / Q000493:pharmacokinetics* / Q000494:pharmacology*; D008297:Male; D011802:Quinidine / Q000493:pharmacokinetics* / Q000494:pharmacology*; D013050:Spectrometry, Fluorescence
D000889:Anti-Arrhythmia Agents; D006993:Hypnotics and Sedatives; D011802:Quinidine; D003975:Diazepam