Modulation of pan-cadherin expression in alveolar epithelial cells of mini pigs with pulmonary fibrosis.
The expression of pan-cadherin was investigated immunohistochemically in normal and irradiated mini pig lungs. Using a double labelling immunofluorescence technique, pan-cadherin expression was also compared with that of cytokeratin 18, which is selectively present in type II cells. In untreated animals pan-cadherin was detected in type I pneumocytes, in alveolar macrophages and in endothelial cells of larger blood vessels. Radiation caused increased pan-cadherin immunoreactivity of bronchial epithelial cells and interstitial cells. In addition, pan-cadherin expression was induced in type II pneumocytes. These changes in the distribution of epithelial cadherin molecules may implicate a role of cadherins for epithelial remodeling in response to radiation-induced lung injury.
Kasper
M
M
Institute of Pathology, Technical University Dresden, Germany.
Müller
M
M
D000818:Animals; D001980:Bronchi / Q000166:cytology / Q000528:radiation effects; D015820:Cadherins / Q000096:biosynthesis*; D004730:Endothelium, Vascular / Q000378:metabolism; D004848:Epithelium / Q000378:metabolism / Q000528:radiation effects; D005455:Fluorescent Antibody Technique; D007633:Keratins / Q000096:biosynthesis*; D008168:Lung / Q000098:blood supply / Q000378:metabolism / Q000473:pathology / Q000528:radiation effects; D016676:Macrophages, Alveolar / Q000378:metabolism; D011650:Pulmonary Alveoli / Q000166:cytology / Q000378:metabolism* / Q000473:pathology / Q000528:radiation effects; D011658:Pulmonary Fibrosis / Q000378:metabolism* / Q000473:pathology; D013552:Swine; D013556:Swine, Miniature; D016707:Tissue Fixation
D015820:Cadherins; D007633:Keratins