A new point of view on the problem of G-protein aggregation. Assembly-disassembly of tubulin as an oscillation process.
Basic principles of nonlinear thermodynamics are used to develop a theory of tubulin assembly. The presence of GTP/GDP switch provides different ways for tubulin aggregation. The GTP-tubulin assembly results in determining the regime of limit cycle favoring growth of tubulin spiral with the formation of microtubules. The GDP-tubulin assembly, on the contrary, results in forming double rings. The difference between the GTP- and GDP-tubulin assemblies is that the former is a dynamical oscillation process while the latter is no more than a transition from a weakly nonequilibrium point to the equilibrium state along a thermodynamical path. Corresponding equations for the GTP- and GDP-tubulin assemblies are proposed.
Tulub
A A
AA
Biological Faculty, St. Petersburg State University.
Skaletskii
E K
EK
Stefanov
V E
VE
Pavlenko
V K
VK
D019204:GTP-Binding Proteins / Q000737:chemistry*; D008958:Models, Molecular; D013816:Thermodynamics; D014404:Tubulin / Q000737:chemistry*
D014404:Tubulin; D019204:GTP-Binding Proteins