title: Hypertension-induced dysfunction of circulation in hemorrhagic shock.
abstract: Arterial blood pressure and plasma concentration of Na+, K+, glucose, and urea were studied in patients with essential hypertension during hemorrhagic shock. All 15 patients had established essential hypertension, and all had massive hemorrhage and shock. The control group included 37 normotensive patients in hemorrhagic shock. There were no differences in blood volume loss and age between the hypertensive and normotensive groups. A significant reduction (P < .001) of systolic and diastolic blood pressure as well as plasma concentration of Na+ and K+ were observed in hypertensive patients with hemorrhagic shock as compared with normotensive patients in hemorrhagic shock. Hypertensive patients in shock were found to have significantly elevated (P < .001) plasma glucose, urea, and heart rate compared with normotensive patients in shock. The hypertensive group mortality was significantly (P < .001) higher (80%) than the normotensive group in shock (24.3%). These data suggest that essential hypertension induces alterations in regulation and modulation of peripheral resistance, Na+/K+ membrane exchange, and the metabolism of glucose and urea during hemorrhagic shock. This heterogeneity of dysfunction induced by essential hypertension during hemorrhagic shock is probably caused by a change in the mechanism (diminish) of oxygen consumption at the cellular level, which results in an increase in nitric oxide production (which is O2 dependent), and may play an important role in hypertension and hemorrhagic shock.
authors.affiliation: Shock Trauma Institute, School of Medicine, Loyola University Chicago, Maywood, Illinois 60153, USA.
authors.forename: Z
authors.initials: Z
authors.lastname: Radisavljevic
mesh_terms: D000006:Abdomen, Acute / Q000503:physiopathology; D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D001806:Blood Urea Nitrogen; D002352:Carrier Proteins / Q000097:blood; D005260:Female; D006339:Heart Rate / Q000502:physiology; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000503:physiopathology*; D008297:Male; D008565:Membrane Proteins / Q000097:blood; D008875:Middle Aged; D012771:Shock, Hemorrhagic / Q000150:complications / Q000503:physiopathology*; D028021:Sodium-Potassium-Chloride Symporters; D014655:Vascular Resistance / Q000502:physiology
chemical_list: D001786:Blood Glucose; D002352:Carrier Proteins; D006454:Hemoglobins; D008565:Membrane Proteins; D028021:Sodium-Potassium-Chloride Symporters