title: Plasma levels and urinary excretion of iodine after oral administration of iohexol in dogs and cats.
abstract: OBJECTIVE
  Plasma and urinary iodine concentrations were assessed after oral administration of iohexol in five dogs and five cats.
  
  
  METHODS
  Ventrodorsal and right lateral radiographs were taken; a 3-mL blood sample was collected 30 minutes and 1, 2, 4, and 6 hours after dose in each animal; and the bladder was emptied at 2 and 6 hours in dogs and at 6 hours in cats after oral administration of 700 mg I/kg iohexol (300 mg I/mL). Iodine concentration was measured using a sequential inductively coupled plasma atomic emission spectrometer system.
  
  
  RESULTS
  Peak concentrations of plasma iodine were detected in samples taken from both dogs (0.33 mg I/mL) and cats (0.28 mg I/mL) 30 minutes after iohexol administration, with a gradual decline at 1, 2, 4, and 6 hours. Total urinary excretion during the 6 hours after the administration does of iohexol was higher (4.3%) in cats than in dogs (2.0%). In each species, there was a relationship between gastrointestinal motility observed radiographically and the subsequent excretion of iodine in the urine.
  
  
  CONCLUSIONS
  Results indicate that approximately 2% of the oral dose is absorbed and excreted in the urine of dogs within 6 hours, and approximately 4% of the dose is absorbed and excreted in cats.
authors.affiliation: Departmento de Patologiá Animal (Medicina, Cirugá Clínica y Radiología), Facultad de Verterinaria, Universidad de Murcia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Agut
authors.forename: F G
authors.initials: FG
authors.lastname: Laredo
authors.forename: M A
authors.initials: MA
authors.lastname: Sánchez-Valverde
authors.forename: J
authors.initials: J
authors.lastname: Murciano
authors.forename: M C
authors.initials: MC
authors.lastname: Tovar
mesh_terms: D000284:Administration, Oral; D000818:Animals; D002415:Cats; D003287:Contrast Media / Q000008:administration & dosage* / Q000494:pharmacology; D004285:Dogs; D005260:Female; D007455:Iodine / Q000097:blood* / Q000652:urine*; D007472:Iohexol / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male
chemical_list: D003287:Contrast Media; D007472:Iohexol; D007455:Iodine