title: Monoclonal expansion of large granular lymphocytes with a CD4+ CD8dim+/- phenotype associated with hairy cell leukemia.
abstract: Peripheral blood lymphoid cell expansions with an unusual CD3+, CD4+, CD8dim+/-, CD11b+, CD57+ immunophenotype have recently been reported. They frequently have the morphology of large granular lymphocytes (LGL) and can be either monoclonal or polyclonal. Their significance is still unclear and no association with hematological neoplasms has been described. We report the case of a patient with a monoclonal expansion of LGL associated with a B-cell-derived hairy cell leukemia. The two lymphoid clones were not physically associated since T-LGL were found in the peripheral blood and hairy cells were detected in the bone marrow and kidney.
authors.affiliation: Servizio di Immunologia Clinica, Spedali Civili ed Università, Brescia, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Airò
authors.forename: G
authors.initials: G
authors.lastname: Rossi
authors.forename: F
authors.initials: F
authors.lastname: Facchetti
authors.forename: D
authors.initials: D
authors.lastname: Marocolo
authors.forename: L
authors.initials: L
authors.lastname: Garza
authors.forename: A
authors.initials: A
authors.lastname: Lanfranchi
authors.forename: E
authors.initials: E
authors.lastname: Prati
authors.forename: D
authors.initials: D
authors.lastname: Brugnoni
authors.forename: F
authors.initials: F
authors.lastname: Malacarne
authors.forename: R
authors.initials: R
authors.lastname: Cattaneo
mesh_terms: D000368:Aged; D015703:Antigens, CD / Q000032:analysis*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000032:analysis; D000951:Antigens, Neoplasm / Q000032:analysis; D001402:B-Lymphocytes / Q000473:pathology; D001853:Bone Marrow / Q000473:pathology; D018845:CD11 Antigens / Q000032:analysis; D015704:CD4 Antigens / Q000032:analysis; D018959:CD57 Antigens; D016827:CD8 Antigens / Q000032:analysis; D002999:Clone Cells / Q000473:pathology*; D006801:Humans; D016130:Immunophenotyping; D007668:Kidney / Q000473:pathology; D007943:Leukemia, Hairy Cell / Q000097:blood / Q000473:pathology*; D008213:Lymphocyte Activation; D008297:Male; D014411:Neoplastic Stem Cells / Q000473:pathology; D016176:T-Lymphocyte Subsets
chemical_list: D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D000951:Antigens, Neoplasm; D018845:CD11 Antigens; D015704:CD4 Antigens; D018959:CD57 Antigens; D016827:CD8 Antigens