Constitutional heteromorphism of 9q13 --> q21 in a patient with chronic myelogenous leukemia.
Cytogenetic studies were carried out in a 44-year-old white male because of newly diagnosed chronic myelogenous leukemia. His initial bone marrow study revealed 46,XY, var(9)(q13 -->q21)/46,XY,var(9) (q13-->q21), t(9;22)(q34;q11) karyotypes and later he also acquired a 47,XY,+8,var(9)(q13-->q21), t(9;22)(q34;q11) clone. The var(9)(q13-->q21) heteromorphism was observed in the normal 9 homolog, in 200 GTG-banded bone marrow metaphases in seven cytogenetic studies (1988-90). This heteromorphism was observed in the normal cell line, in the two chronic myelogenous leukemia-related clones, as well as in 100 mitogen-induced peripheral blood lymphocytes, indicating its constitutional nature. This seems to be the first report of var(9)(q13 --> q21) heteromorphism, involving GTG-positive euchromatic band, in a chronic myelogenous leukemia proband.
Surana
R B
RB
Armed Forces Institute of Pathology, Washington, DC, USA.
Rafi
S K
SK
Christopher
K L
KL
Reid
T J
TJ
Weiss
R B
RB
D000328:Adult; D002843:Chromatin / Q000737:chemistry; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002899:Chromosomes, Human, Pair 9; D022041:Euchromatin; D006801:Humans; D007621:Karyotyping; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000235:genetics*; D008297:Male
D002843:Chromatin; D022041:Euchromatin