Decreased DOPAC in the anterior cingulate cortex of individuals with schizophrenia.
The dopamine metabolite, 3,4-dihydroxyphenylacetic acid (DOPAC), was found to be decreased in the anterior cingulate cortex of individuals with schizophrenia compared with normal controls. The finding does not appear to be solely related to the presence of antipsychotic medications, age, postmortem interval, or freezer time. No changes in norepinephrine and its metabolites were found.
Wyatt
R J
RJ
Neuropsychiatry Branch NIH-NIMH Neuroscience Center at St. Elizabeths, Washington, DC 20032, USA.
Karoum
F
F
Casanova
M F
MF
D015102:3,4-Dihydroxyphenylacetic Acid / Q000032:analysis* / Q000378:metabolism*; D000328:Adult; D000367:Age Factors; D000368:Aged; D014150:Antipsychotic Agents / Q000627:therapeutic use; D001344:Autopsy; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry; D006179:Gyrus Cinguli / Q000737:chemistry* / Q000378:metabolism*; D006719:Homovanillic Acid / Q000032:analysis / Q000378:metabolism; D006801:Humans; D008297:Male; D008499:Medical Records; D008734:Methoxyhydroxyphenylglycol / Q000032:analysis / Q000378:metabolism; D008875:Middle Aged; D009647:Normetanephrine / Q000032:analysis / Q000378:metabolism; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy / Q000378:metabolism*
D014150:Antipsychotic Agents; D009647:Normetanephrine; D015102:3,4-Dihydroxyphenylacetic Acid; D008734:Methoxyhydroxyphenylglycol; D006719:Homovanillic Acid