Inhibition of tumor cell growth by a human B-cell line.
An Adenocarcinoma cell line (Breast-M) and an Epstein-Barr virus (EBV)-infected B-cell line (Hairy-BM) were established from breast tumor tissue. The Hairy-BM was CD20+, CD25 (Tac)+ and surface immunoglobulin (sIg)+. Hairy-BM suppressed the in vitro proliferation of Breast-M in a time- and a dose-dependent manner. The suppression was also found in 5 different human tumor targets showing tumor-Hairy-BM binding, but not; in 2 murine tumor targets showing no significant tumor-Hairy-BM binding. Lytic activity of Hairy-BM was found only against Breast-M.
Katano
M
M
Department of Surgery, Saga Medical School, Japan.
Kubota
E
E
Nagumo
F
F
Matsuo
T
T
Hisatsugu
T
T
Tadano
J
J
D000230:Adenocarcinoma / Q000276:immunology* / Q000473:pathology; D018951:Antigens, CD20 / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D002470:Cell Survival / Q000502:physiology; D004396:Coloring Agents; D004854:Herpesvirus 4, Human; D006801:Humans; D007111:Immunity, Cellular / Q000276:immunology; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D007943:Leukemia, Hairy Cell / Q000276:immunology; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D016133:Polymerase Chain Reaction; D011947:Receptors, Antigen, B-Cell / Q000276:immunology; D015375:Receptors, Interleukin-2 / Q000276:immunology; D013778:Tetrazolium Salts; D013844:Thiazoles; D014407:Tumor Cells, Cultured
D018951:Antigens, CD20; D004396:Coloring Agents; D011947:Receptors, Antigen, B-Cell; D015375:Receptors, Interleukin-2; D013778:Tetrazolium Salts; D013844:Thiazoles; C022616:thiazolyl blue