title: Local and distant products from modularity.
abstract: In this study, the local and distant distribution of solid and soluble products of corrosion from the head and neck junction of modular femoral total hip prosthetic components were characterized. Particulate corrosion products from retrieved implants and surrounding tissues were analyzed. Serum transport and urinary excretion of metal was measured in correlation with the degree of corrosion at the head and neck junction. Particles of metal oxides, metal chlorides, and chromium phosphate corrosion products were identified on implants of 10 designs from 6 manufacturers. The most abundant solid corrosion product on the implant and within the periprosthetic tissues (size range, < 1-200 micrometers) was an amorphous chromium orthophosphate hydrate-rich material. Serum cobalt and urine chromium concentrations were elevated significantly in patients with implants that had moderate to severe corrosion in comparison with those with no to mild corrosion. Solid corrosion products from modular femoral stems may accelerate articular wear via a 3-body mechanism. Phagocytosable particles of these corrosion products may stimulate macrophage-mediated periprosthetic bone loss. Systemic dissemination of metallic corrosion products raises the issue of systemic toxicity; however, no overt evidence of metal toxicity was observed in this study.
authors.affiliation: Department of Orthopedic Surgery, Rush-Presbyterian-St Lukes Medical Center, Chicago, IL 60612, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Jacobs
authors.forename: R M
authors.initials: RM
authors.lastname: Urban
authors.forename: J L
authors.initials: JL
authors.lastname: Gilbert
authors.forename: A K
authors.initials: AK
authors.lastname: Skipor
authors.forename: J
authors.initials: J
authors.lastname: Black
authors.forename: M
authors.initials: M
authors.lastname: Jasty
authors.forename: J O
authors.initials: JO
authors.lastname: Galante
mesh_terms: D000328:Adult; D000368:Aged; D000497:Alloys; D002857:Chromium / Q000032:analysis / Q000652:urine; D003035:Cobalt / Q000097:blood; D003343:Corrosion; D005260:Female; D006622:Hip Prosthesis; D006801:Humans; D017746:Joint Capsule / Q000473:pathology; D008297:Male; D008670:Metals / Q000032:analysis; D008855:Microscopy, Electron, Scanning; D008875:Middle Aged; D011474:Prosthesis Design
chemical_list: D000497:Alloys; D008670:Metals; D002857:Chromium; D003035:Cobalt