Single T cell probes for antigen/MHC expression.
T-cell receptor binding to the antigen/MHC ligand on the surface of antigen-presenting cells is the central event in T-cell activation. Methods have been developed for measuring this recognition event in single T cells and have allowed their use as 'probes' for antigen/MHC expression. Single cell assays have allowed analysis of early events in T-cell activation, and of unknown ligands recognized by the T-cell receptor.
Shastri
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Department of Molecular and Cell Biology, University of California, Berkeley 94720-3200, USA.
D000818:Animals; D006801:Humans; D015335:Molecular Probes / Q000276:immunology*; D011948:Receptors, Antigen, T-Cell / Q000032:analysis*; D013601:T-Lymphocytes / Q000737:chemistry*
D015335:Molecular Probes; D011948:Receptors, Antigen, T-Cell