title: Nonreceptor protein tyrosine kinase involvement in signal transduction and immunodeficiency disease.
abstract: The nonreceptor protein tyrosine kinases (PTKs) have been grouped into 10 different enzyme families based on predicted amino acid sequences. As the number of enzymes belonging to the nonreceptor class of PTK is increasing, one challenge is to determine how these various classes of PTKs interact within the cell to promote signal transduction. Herein, the activation of four classes of nonreceptor PTKs is discussed in relation to their interactions with each other as well as with other signaling molecules during the process of lymphocyte surface antigen receptor-mediated activation. Recent findings of nonreceptor PTK loss-of-function mutations in different immunodeficiency diseases has revealed the important contribution of this group of enzymes to lymphocyte development.
authors.affiliation: Department of Molecular Oncology, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Saouaf
authors.forename: A L
authors.initials: AL
authors.lastname: Burkhardt
authors.forename: J B
authors.initials: JB
authors.lastname: Bolen
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000201:enzymology*; D008969:Molecular Sequence Data; D011505:Protein-Tyrosine Kinases / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology
chemical_list: D011505:Protein-Tyrosine Kinases