The operative peritoneal fibrinolytic response to abdominal operation.
OBJECTIVE
To measure changes in the fibrinolytic properties of human peritoneum during operation.


METHODS
Open study.


METHODS
University hospital, UK.


METHODS
20 patients undergoing elective operations for non-inflammatory disease.


METHODS
Peritoneum was biopsied at the beginning and end of operation.


METHODS
Peritoneal plasminogen activating activity (PAA) and the concentrations of tissue plasminogen activator (t-PA), urokinase, and plasminogen activator inhibitors 1 and 2 were measured at both time points.


RESULTS
Peritoneal PAA was reduced over the time of the operation (p < 0.05) as was the concentration of t-PA (p < 0.05). The urokinase concentration rose significantly (p < 0.05), but plasminogen activator inhibitors 1 and 2 were not detected.


CONCLUSIONS
Elective abdominal operation caused an immediate reduction in peritoneal PAA which seemed to be secondary to a reduced concentration of t-PA. Such a reduction in peritoneal fibrinolytic activity allows the early deposition of fibrinous deposits within the peritoneal cavity.
Scott-Coombes
D M
DM
Department of Surgery, Hammersmith Hospital, London, England.
Whawell
S A
SA
Thompson
J N
JN
D000005:Abdomen / Q000601:surgery*; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D005342:Fibrinolysis; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D010537:Peritoneum / Q000378:metabolism*; D010960:Plasminogen Activators / Q000378:metabolism; D015849:Plasminogen Inactivators / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
D015849:Plasminogen Inactivators; D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator