Dysgerminoma of the ovary in a patient with triple-X syndrome.
A 24-year-old patient with dysgerminoma of the right ovary and hypoplastic left ovary was screened for chromosomal aberration. Triple-X syndrome was found in the oral epithelium and lymphocyte culture, while chromosomal in situ hybridization of the tumor itself showed a normal XX karyotype. Although trisomy X and dysgerminoma are coincidental findings in our case report, women with malignant germ cell tumors and abnormal genitalia should be checked for chromosomal aberrations to exclude anomalies carrying a Y chromosome.
Kemp
B
B
Department of Obstetrics and Gynaecology, Technical University Hospital of Aachen, Germany.
Hauptmann
S
S
Schröder
W
W
Amo-Takyi
B
B
Leeners
B
B
Rath
W
W
D000328:Adult; D004407:Dysgerminoma / Q000150:complications* / Q000473:pathology; D005260:Female; D006801:Humans; D010051:Ovarian Neoplasms / Q000150:complications* / Q000473:pathology; D014314:Trisomy; D014960:X Chromosome