Characterization of ALVA-41 cells, a new human prostatic cancer cell line.
The ALVA-41 cell line was derived from a bony metastasis from a human prostatic carcinoma. The line has a number of distinct, advantageous properties that should make it useful as a tool for the study of prostate cancer. It grows rapidly and is easy to work with. It has receptors for androgens and glucocorticoids but not for estrogens. Its growth is enhanced by physiological concentrations of dihydrotestosterone. It does not secrete prostate specific antigen, but does secrete prostatic acid phosphatase. Further, the secretion of prostatic acid phosphatase is enhanced by dihydrotestosterone.
Nakhla
A M
AM
Department of Medicine, St. Luke's-Roosevelt Hospital Center, Columbia University, New York, NY 10019.
Rosner
W
W
D000135:Acid Phosphatase / Q000378:metabolism; D000230:Adenocarcinoma / Q000201:enzymology / Q000473:pathology* / Q000556:secondary*; D001859:Bone Neoplasms / Q000556:secondary*; D002448:Cell Adhesion / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D042944:Cholestenone 5 alpha-Reductase; D006801:Humans; D008297:Male; D010088:Oxidoreductases / Q000378:metabolism; D017430:Prostate-Specific Antigen / Q000032:analysis; D011471:Prostatic Neoplasms / Q000201:enzymology / Q000473:pathology* / Q000648:ultrastructure; D011944:Receptors, Androgen / Q000378:metabolism; D011960:Receptors, Estrogen / Q000378:metabolism; D011965:Receptors, Glucocorticoid / Q000378:metabolism; D014407:Tumor Cells, Cultured / Q000473:pathology*
D011944:Receptors, Androgen; D011960:Receptors, Estrogen; D011965:Receptors, Glucocorticoid; D010088:Oxidoreductases; D042944:Cholestenone 5 alpha-Reductase; D000135:Acid Phosphatase; D017430:Prostate-Specific Antigen