title: Morphological and morphometric study of atrial specific granules and other secretory components in dogs experimentally infected with Trypanosoma cruzi.
abstract: Changes in blood volume can induce morphometric and morphological alterations in the secretory complex of the myoendocrine cells due to the stretching of atrial walls. These alterations were studied by electron microscopy, using dogs infected intraperitonially with Trypanosoma cruzi and necropsied during the acute phase of the infection when congestive heart failure was present. Several changes were observed in the myoendocrine cells of the heart: hypertrophy and hyperplasia of rough endoplasmic reticulum and Golgi complex, increase in telenuclear secretory complex, increase in fusion of type B atrial specific granules (ASG), decrease of the total number of ASG, enlargement of the maximum diameter of type A ASG and a relative increase in the number of type B ASG. These alterations suggest a larger secretory activity of the atrial myoendocrine cells with a larger secretion of atrial natriuretic peptide (ANP).
authors.affiliation: Departamento de Patologia Geral, Universidade Federal de Minas Gerais, Brasil.
authors.forename: M V
authors.initials: MV
authors.lastname: Caliari
authors.forename: M
authors.initials: M
authors.lastname: Lana
authors.forename: V H
authors.initials: VH
authors.lastname: Leite
authors.forename: W L
authors.initials: WL
authors.lastname: Tafuri
mesh_terms: D000208:Acute Disease; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000378:metabolism; D002598:Chagas Cardiomyopathy / Q000473:pathology*; D003594:Cytoplasmic Granules / Q000648:ultrastructure*; D004285:Dogs; D004721:Endoplasmic Reticulum / Q000648:ultrastructure; D006056:Golgi Apparatus / Q000648:ultrastructure; D006333:Heart Failure / Q000473:pathology; D008854:Microscopy, Electron; D009206:Myocardium / Q000648:ultrastructure*
chemical_list: D009320:Atrial Natriuretic Factor