title: Nucleotide sequence of the genes encoding the canine herpesvirus gB, gC and gD homologues.
abstract: The nucleotide sequence of the genes encoding the canine herpesvirus (CHV) gB, gC and gD homologues was determined. These genes are predicted to encode polypeptides of 879, 459 and 345 amino acids, respectively. Comparison of the predicted amino acid sequences of CHV gB, gC and gD with the homologous sequences from other herpesviruses indicates that CHV is an alphaherpesvirus, a conclusion that is consistent with the previous classification of this virus according to biological properties. Alignment of the homologous gB, gC and gD amino acid sequences indicates that most of the cysteine residues are conserved, suggesting that these glycoproteins possess similar tertiary structures. The nucleotide sequence of the open reading frame downstream from the CHV gC gene was also determined. The predicted amino acid sequence of this putative polypeptide appears to be homologous to a family of proteins encoded downstream from the gC gene in most, although not all, alphaherpesviruses.
authors.affiliation: Virogenetics Corporation, Troy, New York 12180-8349.
authors.forename: K J
authors.initials: KJ
authors.lastname: Limbach
authors.forename: M P
authors.initials: MP
authors.lastname: Limbach
authors.forename: D
authors.initials: D
authors.lastname: Conte
authors.forename: E
authors.initials: E
authors.lastname: Paoletti
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D004285:Dogs; D005814:Genes, Viral / Q000235:genetics*; D016679:Genome, Viral; D006564:Herpesviridae / Q000235:genetics*; D008969:Molecular Sequence Data; D016366:Open Reading Frames / Q000235:genetics; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D014759:Viral Envelope Proteins / Q000235:genetics*
chemical_list: D014759:Viral Envelope Proteins; C088592:glycoprotein B, Canid herpesvirus 1; C088593:glycoprotein C, Canid herpesvirus 1; C088594:glycoprotein D, Canid herpesvirus 1