title: MF59. Design and evaluation of a safe and potent adjuvant for human vaccines.
abstract: MF59 is a safe, practical, and potent adjuvant for use with human vaccines. The formulation is easily manufactured, may be sterilized by filtration, and is both compatible and efficacious with all antigens tested to date. MF59 has been shown to be a potent stimulator of cellular and humoral responses to subunit antigens in both animal models and clinical studies. Toxicology studies in animal models and Phase I-III studies in humans have demonstrated the safety of MF59 with HSV, HIV, and influenza vaccines.
authors.affiliation: Chiron Corporation, Emeryville, California 94608, USA.
authors.forename: G
authors.initials: G
authors.lastname: Ott
authors.forename: G L
authors.initials: GL
authors.lastname: Barchfeld
authors.forename: D
authors.initials: D
authors.lastname: Chernoff
authors.forename: R
authors.initials: R
authors.lastname: Radhakrishnan
authors.forename: P
authors.initials: P
authors.lastname: van Hoogevest
authors.forename: G
authors.initials: G
authors.lastname: Van Nest
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis* / Q000737:chemistry; D000818:Animals; D015195:Drug Design; D004655:Emulsions; D006801:Humans; D011136:Polysorbates / Q000138:chemical synthesis* / Q000737:chemistry; D013185:Squalene / Q000138:chemical synthesis* / Q000737:chemistry / Q000276:immunology; D014612:Vaccines / Q000008:administration & dosage / Q000276:immunology
chemical_list: D000276:Adjuvants, Immunologic; D004655:Emulsions; C089950:MF59 oil emulsion; D011136:Polysorbates; D014612:Vaccines; D013185:Squalene