[In vivo study of the functional activity of peripheral blood leukocytes of intact and irradiated dogs with an inactivation test of endogenous hemopoietic stem cells of sublethally irradiated mice].
Peripheral blood leukocytes of intact dogs, when transplanted to sublethally irradiated mice, have been found to suppress endogenous colony formation. The inactivation effect in hemopoietic stem cells of mice is enhanced with an increase in the number of effector cells in the graft. Radiation exposure results in failure of the effector function of leukocytic cells at the peak of acute radiation sickness. Nine months after irradiation, the inactivating capacity of dog leukocytes is restored and exceeds that of the control. Administered to dogs 9 months after irradiation, proteus vaccine stimulated the effector function of leukocytes at days 7 and 28 and suppressed it at days 14 and 62 post-administration.
Man'ko
V M
VM
Borovkova
N V
NV
Andrushchenko
V N
VN
D000818:Animals; D001428:Bacterial Vaccines / Q000008:administration & dosage / Q000276:immunology; D004285:Dogs; D006412:Hematopoietic Stem Cells / Q000276:immunology* / Q000528:radiation effects*; D007156:Immunologic Memory; D017708:Leukocyte Transfusion; D007962:Leukocytes / Q000276:immunology* / Q000528:radiation effects*; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011511:Proteus / Q000276:immunology; D013997:Time Factors
D001428:Bacterial Vaccines