MI survivors: using drug therapies to protect the heart.
Survivors of myocardial infarction are at increased risk for another MI, congestive heart failure, ventricular arrhythmias, and sudden death. Beta blockers reduce the rate of sudden death, reinfarction, and recurrent ischemia, particularly in elderly patients. Chronic aspirin therapy has shown significant reductions in cardiovascular morbidity and mortality and is recommended for all post-MI patients who can tolerate it. ACE inhibitor therapy has shown benefit in patients with impaired LV function. Identifying post-MI patients at risk for sudden death and preventing fatal arrhythmias has proven difficult. Class I antiarrhythmics should be avoided. Amiodarone and perhaps sotalol appear promising, but large-scale trials are still ongoing.
Amidon
T M
TM
Department of Medicine, University of California, San Francisco, USA.
D000368:Aged; D001145:Arrhythmias, Cardiac / Q000188:drug therapy; D002317:Cardiovascular Agents / Q000627:therapeutic use*; D003645:Death, Sudden; D006333:Heart Failure / Q000188:drug therapy; D006352:Heart Ventricles; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000188:drug therapy; D012008:Recurrence; D012307:Risk Factors; D016019:Survival Analysis
D002317:Cardiovascular Agents