Acute systemic blood pressure elevation in obstructive and nonobstructive breath hold in primates.
Phasic blood pressure (BP) response during obstructive apnea (OA) in human sleep has been previously described as consisting of a slow incremental increase in BP to the point of apnea termination followed by a rapid rise and then fall in BP at the resumption of respiration. This rise in BP has been attributed to postapneic augmentation of cardiac output resulting after release of the marked negative intrathoracic pressure (NIP) of obstructed inspiration. Via an endotracheal tube, we created obstructed and nonobstructed breath hold (apnea) in chloralose-anesthesized baboons consisting of fixed-duration (30, 45, and 60 s) single OAs (mechanical obstruction) and nonobstructive (paralysis, ventilator cessation) apneas of matched duration and arterial desaturation. Systemic BP was measured before apnea (T0), during the last 5 s of apnea (T1), and during the first 5 s after resumption of respiration (T2). Despite wide fluctuations in NIP and BP during the T0 to T1 phase of OA, BP elevation in OA and nonobstructive apnea at T0, T1, or T2 did not differ for any duration apnea. At the release of obstruction, when resolution of NIP changes could theoretically increase cardiac output and accentuate BP, there was no difference in T1 and T2 pressures between the two conditions. We conclude that in this anesthesized animal model, mechanical (NIP) changes do not play a major role in overall maximum BP response to OA. Because of physiological differences between natural sleep in humans and the anesthetized state in animals, care must be taken in extrapolating these results to human sleep apnea.
White
S G
SG
Department of Medicine, Houston Veterans Affairs Medical Center, Texas, USA.
Fletcher
E C
EC
Miller
C C
CC
D000402:Airway Obstruction / Q000503:physiopathology*; D000818:Animals; D001049:Apnea / Q000503:physiopathology*; D001794:Blood Pressure; D002302:Cardiac Output; D005260:Female; D010215:Papio; D011312:Pressure; D012119:Respiration; D013909:Thorax / Q000503:physiopathology; D013997:Time Factors