title: Alloimmunizations following blood transfusions.
abstract: A retrospective study was performed to estimate the rate of alloimmunization against red blood cell (RBC) antigens in hospitalized patients and the frequency and specificity of clinically significant alloantibodies (CSA) detected during routine pretransfusion testing of 10,641 blood samples. Clinically significant alloantibodies were found in 116 out of the 10,641 tested serums (1.09%). The incidence of CSA in two surgical groups of patients was 0.18% and 0.68%, respectively. In patients with hematologic diseases the frequency of CSA was 17.6%, in patients with uremic disease it was 14%, and in patients with cirrhosis hepatis it was 6.9%. The incidence of clinically significant alloantibodies in patients who had one to five exposures to RBC antigens was 5.1%; in patients who had six to fifteen exposures, 87.9%; and in patients with more than fifteen exposures, 6.8%. The most frequently found single alloantibodies were anti-Kell (22%), and the following irregular alloantibodies were found with decreasing frequency: anti-E (20%), anti-D (11%), anti-c (10%), anti-C (7%), anti-Kidd (6%). The most frequent alloantibodies found together with other alloantibodies had anti-Duffy specificity (80%), and the following irregular alloantibodies were found with decreased frequency: anti-C (70%), anti-c (57%), and anti-Kidd (50%).
authors.affiliation: Blood Transfusion Centre, Republic of Croatia, Zagreb.
authors.forename: Z
authors.initials: Z
authors.lastname: Hundrić-Haspl
authors.forename: N
authors.initials: N
authors.lastname: Juraković-Loncar
authors.forename: D
authors.initials: D
authors.lastname: Grgicević
authors.forename: M
authors.initials: M
authors.lastname: Balija
mesh_terms: D005260:Female; D006801:Humans; D007518:Isoantibodies / Q000097:blood*; D008297:Male; D012189:Retrospective Studies; D065227:Transfusion Reaction
chemical_list: D007518:Isoantibodies