[Low titer cold agglutinin disease due to anti-HI antibody and a review of this disease in Japan].
A 79 year-old Japanese man was admitted because of brownish urine and Raynaud phenomenon. Laboratory data showed mild anemia with reticulocytosis, positive direct Coombs test against anti-C3, elevated level of lactate dehydrogenase, undetectable level of serum haptoglobin and low titer of cold agglutinin (1:256 at 4 degrees C), the immunoglobulin subclass of which was IgM. Cold agglutinin disease is usually associated with very high levels of cold agglutinins, the specificity of which is anti-I. This case had low titer cold agglutinin disease due to anti-HI cold agglutinin.
Yamauchi
H
H
First Department of Internal Medicine, Ehime University.
Iwamasa
K
K
Yanagisawa
K
K
Tamai
T
T
Yasukawa
M
M
Fujita
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D000373:Agglutinins / Q000032:analysis*; D000744:Anemia, Hemolytic, Autoimmune / Q000276:immunology*; D001323:Autoantibodies / Q000032:analysis*; D003080:Cold Temperature; D003450:Cryoglobulins; D000939:Epitopes; D005260:Female; D006388:Hemagglutinins / Q000032:analysis*; D006801:Humans; D008297:Male; D008875:Middle Aged
D000373:Agglutinins; D001323:Autoantibodies; D003450:Cryoglobulins; D000939:Epitopes; D006388:Hemagglutinins; C029443:cold agglutinins