Anaplastic thyroid carcinoma producing the granulocyte colony stimulating factor (G-CSF): report of a case.
We report herein the unusual case of a 60-year-old woman with an anaplastic thyroid carcinoma which produced granulocyte colony stimulating factor (G-CSF). She presented with large neck masses, respiratory difficulty, and a high fever. Laboratory examinations revealed marked leukocytosis of 43,200/mm3 with 85% granulocytes and an elevated G-CSF level of 67 pg/dl. Total thyroidectomy with bilateral node dissection and tracheostomy was performed, and a histological diagnosis of large-cell anaplastic thyroid carcinoma was confirmed. Immunohistochemical examination with a polyclonal antibody against G-CSF stained the tumor cells. Although the respiratory difficulty, fever, and marked granulocytosis subsequently improved, she died 1 month after undergoing surgery due to metastatic mediastinal disease.
Iwasa
K
K
Department of Surgery (II), Kanazawa University Hospital, Kanazawa University School of Medicine, Japan.
Noguchi
M
M
Mori
K
K
Ohta
N
N
Miyazaki
I
I
Nonomura
A
A
Mizukami
Y
Y
Nakamura
S
S
Michigishi
T
T
D002277:Carcinoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D017809:Fatal Outcome; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D008479:Mediastinal Neoplasms / Q000556:secondary; D008875:Middle Aged; D013964:Thyroid Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D013965:Thyroidectomy
D016179:Granulocyte Colony-Stimulating Factor