Opioid peptides content in the rat brain during the ictal phase and after pentylenetetrazol-kindled rats.
We determine the opioid peptide content in the rat brain during the ictal phase and postictal depression after pentylenetetrazol kindling rats. Radioimmunoassays with highly specific antisera risen for Met-enkephalin, Leu-enkephalin and octapeptide, were carried out during the ictal phase, and 15, 30 and 60 min after seizures. We always found an initial IR-Met-enkephalin decrease during the postictal depression content, followed by a reduction in IR-Leu-enkephalin and IR-octapeptide tissular concentration. We suggest a functional and differential release of the opioid peptides, during the postictal depression time-course.
Asai
M
M
Laboratorio de Análisis Químicos, Instituto Mexicano de Psiquiatría, Mexico, D.F. Mexico.
Matamoros-Trejo
G
G
Talavera
E
E
Cano-Martínez
A
A
Avila
M E
ME
D000818:Animals; D001921:Brain / Q000378:metabolism*; D004723:Endorphins / Q000378:metabolism*; D004743:Enkephalin, Leucine / Q000378:metabolism; D004744:Enkephalin, Methionine / Q000378:metabolism; D007696:Kindling, Neurologic; D008297:Male; D010433:Pentylenetetrazole; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000378:metabolism* / Q000503:physiopathology; D013997:Time Factors; D014018:Tissue Distribution
D004723:Endorphins; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D010433:Pentylenetetrazole