Regulation of cellular calcium through signaling cross-talk involves an intricate interplay between the actions of receptors, G-proteins, and second messengers.
Various external stimuli regulate cellular Ca2+ fluxes. Information from these stimuli is transmitted to the cell interior by signal transducing systems that involve interactions between receptors, G-proteins, and enzymes that generate second messengers. The possible mechanisms by which "cross-talk" within and between these second messenger-generating systems provides an intricate molecular avenue for fine modulation of intracellular Ca2+ are reviewed.
Bygrave
F L
FL
Division of Biochemistry and Molecular Biology, Faculty of Science, Australian National University, Canberra, Australia.
Roberts
H R
HR
D017398:Alternative Splicing; D000818:Animals; D002118:Calcium / Q000502:physiology*; D000242:Cyclic AMP / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D018027:Receptors, Glucagon / Q000502:physiology*; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D011979:Receptors, Pituitary Hormone / Q000502:physiology*; D011989:Receptors, Thyrotropin / Q000502:physiology*; D015290:Second Messenger Systems / Q000502:physiology*; D015398:Signal Transduction
D018027:Receptors, Glucagon; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D011979:Receptors, Pituitary Hormone; D011989:Receptors, Thyrotropin; D015544:Inositol 1,4,5-Trisphosphate; D000242:Cyclic AMP; D019204:GTP-Binding Proteins; D002118:Calcium