A better understanding of anti-inflammatory drugs based on isoforms of cyclooxygenase (COX-1 and COX-2).
Vane
J R
JR
William Harvey Research Institute, St Bartholomew's Hospital Medical College, London, UK.
Botting
R M
RM
D000594:Amino Acid Oxidoreductases / Q000378:metabolism; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology*; D015195:Drug Design; D006801:Humans; D007527:Isoenzymes / Q000378:metabolism*; D007700:Kinetics; D017737:Macrophages, Peritoneal / Q000187:drug effects / Q000378:metabolism; D051379:Mice; D009000:Monocytes / Q000187:drug effects / Q000378:metabolism; D019001:Nitric Oxide Synthase; D011451:Prostaglandin-Endoperoxide Synthases / Q000378:metabolism*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016861:Cyclooxygenase Inhibitors; D007527:Isoenzymes; D019001:Nitric Oxide Synthase; D011451:Prostaglandin-Endoperoxide Synthases; D000594:Amino Acid Oxidoreductases