title: Survival curves subjected to occasional insults.
abstract: We describe a parametric family of survival curves which can be used to model time to event data in systems subjected to occasional insults or shocks. Parameters control the location, magnitude, and duration of the effect for each insult. We use these models to describe the survival history of a large cohort of Drosophila that were transferred to new vials on a weekly basis as their nutrient medium deteriorated. A periodic model with fewer parameters exhibits a good fit to the data.
authors.affiliation: Division of Biostatistics, Yale University, New Haven, Connecticut 06520, USA.
authors.forename: D
authors.initials: D
authors.lastname: Zelterman
authors.forename: J W
authors.initials: JW
authors.lastname: Curtsinger
mesh_terms: D000818:Animals; D001699:Biometry; D015331:Cohort Studies; D003470:Culture Media; D003643:Death; D004330:Drosophila; D008136:Longevity; D008297:Male; D008433:Mathematics; D015233:Models, Statistical; D016019:Survival Analysis; D013997:Time Factors
chemical_list: D003470:Culture Media