[Steroidogenesis in the adrenals and gonads of rats following the neonatal administration of hydrocortisone].
Neonatal administration of hydrocortisone decrease steroidogenesis in the rat adrenals in immature and mature animals production of progesterone and androstenedione reducing, at that. Primary long-term disturbance of central regulatory influences controlling steroidogenesis in adrenals, was proposed. The steroid production disturbance in the gonads was lesser than in the adrenals and was found only in mature rats.
Savchenko
O N
ON
Proĭmina
F I
FI
Rakitskaia
V V
VV
Flerova
N I
NI
D000305:Adrenal Cortex Hormones / Q000096:biosynthesis*; D000311:Adrenal Glands / Q000187:drug effects* / Q000378:metabolism; D000375:Aging / Q000187:drug effects / Q000378:metabolism; D000818:Animals; D000831:Animals, Newborn; D006063:Chorionic Gonadotropin / Q000494:pharmacology; D003366:Cosyntropin / Q000494:pharmacology; D005260:Female; D012739:Gonadal Steroid Hormones / Q000096:biosynthesis*; D006854:Hydrocortisone / Q000494:pharmacology*; D008297:Male; D010053:Ovary / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D013737:Testis / Q000187:drug effects* / Q000378:metabolism
D000305:Adrenal Cortex Hormones; D006063:Chorionic Gonadotropin; D012739:Gonadal Steroid Hormones; D003366:Cosyntropin; C006418:adrenocorticotropin zinc; D006854:Hydrocortisone