bcr-abl hybrid messenger RNA in a patient with Philadelphia-negative essential thrombocythemia.
We describe a case of Philadelphia-negative essential thrombocythemia in whom bcr-abl hybrid messenger RNA was detected. The patient suffered from frequent splenic infarctions and myelofibrosis. Interestingly, a transformation to acute leukemia which was commonly seen in patients with bcr-abl-positive chronic myelogenous leukemia did not occur until he died from heart failure due to severe anemia 8 years after the diagnosis. The heterogeneity of bcr-abl-positive thrombocythemia is emphasized.
Hashino
S
S
Third Department of Internal Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
Imamura
M
M
Kobayashi
S
S
Kunieda
Y
Y
Kobayashi
H
H
D016044:Fusion Proteins, bcr-abl / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010677:Philadelphia Chromosome; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000032:analysis*; D012194:RNA-Directed DNA Polymerase; D013920:Thrombocythemia, Essential / Q000175:diagnosis / Q000235:genetics*
D012333:RNA, Messenger; D016044:Fusion Proteins, bcr-abl; D012194:RNA-Directed DNA Polymerase