title: Factors limiting exercise performance in long-term survivors of bronchopulmonary dysplasia.
abstract: The long-term impairment of pulmonary function during exercise was assessed in 12 children, aged 6 to 12 yr, who developed BPD after prematurity (gestational age 30 +/- 2 wk [mean +/- SD] and birth weight 1,400 +/- 335 g) and 16 age-, sex-, and physical activity-matched healthy children born at term, who served as controls. The children performed pulmonary function tests at rest and a maximal stepwise exercise on a treadmill. Oxygen consumption (VO2), carbon dioxide output (VCO2), and minute ventilation (VE) were monitored during the run. Baseline mean spirometric values (% of predicted) were in the normal range for both groups but were lower in BPD children with respect to control children (p < 0.05). At rest, arterial oxygen saturation (SaO2) was > or = 98% in all BPD children, but at peak exercise, 4 of them had a SaO2 fall > or = 4%. The postexercise FEV1 fall, with respect to the baseline, was 8 +/- 6%, in BPD and 2 +/- 1% in control children (p < 0.01). Maximum VO2 and VE were significantly lower in BPD children with respect to the control group (25.2 +/- 10.3 versus 37.1 +/- 10.4 ml/min/kg and 20.8 +/- 9.4 versus 30.7 +/- 7.9 L/min, respectively, both p < 0.01). Also, at submaximal levels of exercise dynamic, VO2 and VE responses were significantly lower in the BPD group (ANOVA, p < 0.001), with a ventilatory pattern characterized by lower tidal volumes. Anaerobic threshold was 20.6 +/- 9 in BPD and 28.8 +/- 8.6 ml O2/min/kg in healthy children (p < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Pediatrics, University of Padova School of Medicine, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Santuz
authors.forename: E
authors.initials: E
authors.lastname: Baraldi
authors.forename: P
authors.initials: P
authors.lastname: Zaramella
authors.forename: M
authors.initials: M
authors.lastname: Filippone
authors.forename: F
authors.initials: F
authors.lastname: Zacchello
mesh_terms: D001997:Bronchopulmonary Dysplasia / Q000503:physiopathology*; D016022:Case-Control Studies; D002648:Child; D005080:Exercise Test; D017079:Exercise Tolerance / Q000502:physiology*; D005260:Female; D005500:Follow-Up Studies; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D007231:Infant, Newborn; D008168:Lung / Q000503:physiopathology*; D008297:Male; D011659:Pulmonary Gas Exchange / Q000502:physiology; D012129:Respiratory Function Tests; D013997:Time Factors