Bioactivity of nickel(II) complex containing N-glycosides derived from D-glucosamine and ethylenediamine against pathogenic yeast, Candida albicans.
A nickel(II) complex containing N-glycosides derived from the reaction of D-glucosamine (D-GlcN) and ethylenediamine (en) [Ni(D-GlcN-en)2]Cl2.H20 showed effective antifungal activity against pathogenic yeast, Candida albicans, where the MIC (minimal concentration of inhibition) value of the complex is 0.25 mM.
Yano
S
S
Department of Chemistry, Faculty of Science, Nara Women's University.
Inoue
S
S
Nouchi
R
R
Kato
M
M
Suzuki
T
T
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects* / Q000648:ultrastructure; D003470:Culture Media; D004492:Edetic Acid / Q000737:chemistry; D005944:Glucosamine / Q000737:chemistry; D006027:Glycosides / Q000494:pharmacology*; D009391:Nephelometry and Turbidimetry; D009532:Nickel / Q000494:pharmacology*; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000494:pharmacology*
D000935:Antifungal Agents; D003470:Culture Media; D006027:Glycosides; D009942:Organometallic Compounds; C096059:bis(2'-amino-2'-deoxy-1'-glucosaminoethylamine)nickel(II); D009532:Nickel; D004492:Edetic Acid; D005944:Glucosamine