Defining the role of endothelins in renal pathophysiology on the basis of selective and unselective endothelin receptor antagonist studies.
The sensitivity of the renal vasculature to endothelin-1 together with the effect of the peptide on the kidney prompted investigators to study the role of endothelin-1 in renal pathophysiology. The kidney expresses both endothelinA and endothelinB receptors, which differ from species to species. Experiments employing specific endothelin receptor antagonists in experimental animals have suggested a role for endothelin-1 in ischaemia-induced acute renal failure and renal disease progression.
Benigni
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Mario Negri Institute for Pharmacological Research, Bergamo, Italy.
D000818:Animals; D065128:Endothelin Receptor Antagonists; D016232:Endothelins / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D007674:Kidney Diseases / Q000378:metabolism / Q000503:physiopathology*; D017466:Receptors, Endothelin / Q000378:metabolism
D065128:Endothelin Receptor Antagonists; D016232:Endothelins; D017466:Receptors, Endothelin