title: Sepsis reduces isoflurane MAC in a normotensive animal model of sepsis.
abstract: Patients with sepsis often require anaesthesia for surgical procedures. Anaesthesia can be unpredictable and the most haemodynamically stable agents are used. No data are available for the minimum alveolar concentration (MAC) requirements in such patients or in animal models of sepsis. We have characterized the effect of sepsis on the MAC of isoflurane in a normotensive rodent model of sepsis. The minimum inhibitory concentration (MIC) of isoflurane to an identical stimulus was determined for rodents subjected to caecal ligation and perforation (CLP n = 8), or sham laparotomy (n = 7). The calculated MAC of isoflurane was reduced in the septic animals compared with the sham animals (MAC of isoflurane, CLP = 0.8%, sham = 1.4% P < 0.003). No statistical differences were found in the haemodynamic variables measured in either group. Isoflurane leads to haemodynamic stability during anaesthesia in this animal model of sepsis. However, the MAC requirement for isoflurane is reduced by sepsis.
authors.affiliation: AC Burton Vascular Laboratory, Victoria Hospital, London, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Gill
authors.forename: C
authors.initials: C
authors.lastname: Martin
authors.forename: T
authors.initials: T
authors.lastname: McKinnon
authors.forename: C
authors.initials: C
authors.lastname: Lam
authors.forename: D
authors.initials: D
authors.lastname: Cunningham
authors.forename: W J
authors.initials: WJ
authors.lastname: Sibbald
mesh_terms: D018685:Anesthetics, Inhalation / Q000493:pharmacokinetics*; D000818:Animals; D001794:Blood Pressure; D004195:Disease Models, Animal; D007530:Isoflurane / Q000493:pharmacokinetics*; D008297:Male; D011650:Pulmonary Alveoli / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018805:Sepsis / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D018685:Anesthetics, Inhalation; D007530:Isoflurane