title: Long-term treatment of pulmonary tuberculosis with ofloxacin in a subject with liver cirrhosis.
abstract: We report on the clinical case of a patient suffering from active pulmonary tuberculosis associated with liver cirrhosis, which limited the use of the major antituberculosis drugs. The patient was treated with a 12 month ofloxacin and ethambutol therapy. At completion of the therapy, the lung cavity disappeared with a considerable reduction of the lung infiltration, as seen in the chest radiograph. At the same time, a positive to negative conversion of the sputum was noted. The only significant side-effect was hyperuricaemia.
authors.affiliation: Dept of Internal Medicine, University of Messina, Italy.
authors.forename: G F
authors.initials: GF
authors.lastname: Bagnato
authors.forename: E
authors.initials: E
authors.lastname: Di Cesare
authors.forename: S
authors.initials: S
authors.lastname: Gulli
authors.forename: D
authors.initials: D
authors.lastname: Cucinotta
mesh_terms: D000284:Administration, Oral; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D000995:Antitubercular Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D004977:Ethambutol / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005500:Follow-Up Studies; D006801:Humans; D008104:Liver Cirrhosis, Alcoholic / Q000150:complications; D008297:Male; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D014527:Uric Acid / Q000097:blood
chemical_list: D000890:Anti-Infective Agents; D000995:Antitubercular Agents; D014527:Uric Acid; D004977:Ethambutol; D015242:Ofloxacin