Plasma levels and urinary excretion of iodine after oral administration of iohexol in dogs and cats.
OBJECTIVE
Plasma and urinary iodine concentrations were assessed after oral administration of iohexol in five dogs and five cats.


METHODS
Ventrodorsal and right lateral radiographs were taken; a 3-mL blood sample was collected 30 minutes and 1, 2, 4, and 6 hours after dose in each animal; and the bladder was emptied at 2 and 6 hours in dogs and at 6 hours in cats after oral administration of 700 mg I/kg iohexol (300 mg I/mL). Iodine concentration was measured using a sequential inductively coupled plasma atomic emission spectrometer system.


RESULTS
Peak concentrations of plasma iodine were detected in samples taken from both dogs (0.33 mg I/mL) and cats (0.28 mg I/mL) 30 minutes after iohexol administration, with a gradual decline at 1, 2, 4, and 6 hours. Total urinary excretion during the 6 hours after the administration does of iohexol was higher (4.3%) in cats than in dogs (2.0%). In each species, there was a relationship between gastrointestinal motility observed radiographically and the subsequent excretion of iodine in the urine.


CONCLUSIONS
Results indicate that approximately 2% of the oral dose is absorbed and excreted in the urine of dogs within 6 hours, and approximately 4% of the dose is absorbed and excreted in cats.
Agut
A
A
Departmento de Patologiá Animal (Medicina, Cirugá Clínica y Radiología), Facultad de Verterinaria, Universidad de Murcia, Spain.
Laredo
F G
FG
Sánchez-Valverde
M A
MA
Murciano
J
J
Tovar
M C
MC
D000284:Administration, Oral; D000818:Animals; D002415:Cats; D003287:Contrast Media / Q000008:administration & dosage* / Q000494:pharmacology; D004285:Dogs; D005260:Female; D007455:Iodine / Q000097:blood* / Q000652:urine*; D007472:Iohexol / Q000008:administration & dosage* / Q000494:pharmacology; D008297:Male
D003287:Contrast Media; D007472:Iohexol; D007455:Iodine