Up-regulation of resistance-related proteins in human lung tumors with poor vascularization.
Microvessel density was investigated by immunostaining endothelial cells for factor VIII antigen in 84 non-small cell lung carcinomas and compared with the expression of several resistance-related proteins. Glutathione S-transferase-pi, thymidylate synthase, metallothionein and, with limitations, P-glycoprotein were overexpressed in tumors with poor vascularization.
Koomägi
R
R
Department of Radiology and Oncology, Tartu University, Estonia.
Mattern
J
J
Volm
M
M
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000096:biosynthesis; D002289:Carcinoma, Non-Small-Cell Lung / Q000098:blood supply* / Q000201:enzymology / Q000378:metabolism*; D002374:Catalase / Q000096:biosynthesis; D019008:Drug Resistance, Neoplasm; D005260:Female; D005982:Glutathione Transferase / Q000096:biosynthesis; D006801:Humans; D007527:Isoenzymes / Q000096:biosynthesis; D008175:Lung Neoplasms / Q000098:blood supply* / Q000201:enzymology / Q000378:metabolism*; D008297:Male; D008668:Metallothionein / Q000096:biosynthesis; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D009389:Neovascularization, Pathologic / Q000201:enzymology / Q000378:metabolism*; D013940:Thymidylate Synthase / Q000096:biosynthesis; D015854:Up-Regulation / Q000502:physiology
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D007527:Isoenzymes; D009363:Neoplasm Proteins; D008668:Metallothionein; D002374:Catalase; D013940:Thymidylate Synthase; D005982:Glutathione Transferase