The role of vascular permeability factor and basic fibroblast growth factor in tumor angiogenesis.
In the last decade a considerable amount of research has been dedicated to studying the process of angiogenesis. In the field of tumor biology angiogenesis is a relevant subject of investigation as well, since newly formed blood vessels are required for the growth of tumors and provide an exit route for metastasizing tumor cells. In this review we discuss some aspects of tumor angiogenesis with emphasis on the role that growth factors bFGF and VPF play in this process. A number of biochemical characteristics and biological properties of the two factors and their receptors are reviewed, and the expression of bFGF and VPF in both normal tissues and in tumors is discussed. Finally, we speculate on the use of bFGF and VPF expression as a diagnostic parameter and on possible clinical applications.
Pötgens
A J
AJ
Department of Pathology, University Hospital Nijmegen, The Netherlands.
Westphal
H R
HR
de Waal
R M
RM
Ruiter
D J
DJ
D000818:Animals; D016228:Endothelial Growth Factors / Q000096:biosynthesis / Q000502:physiology*; D016222:Fibroblast Growth Factor 2 / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D008222:Lymphokines / Q000096:biosynthesis / Q000502:physiology*; D009369:Neoplasms / Q000098:blood supply / Q000378:metabolism / Q000503:physiopathology*; D009389:Neovascularization, Pathologic / Q000503:physiopathology*; D012039:Regional Blood Flow / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D008222:Lymphokines; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D016222:Fibroblast Growth Factor 2