Role of genetic factors in bronchial cancer. Based upon a case of anaplastic lung carcinoma in identical twins.
Having observed homozygotic identical twin brothers suffering simultaneously from anaplastic bronchial cancer leading rapidly to death in both cases, the authors assessed the frequency of such cases. The available literature failed to reveal any identical observations, although four cases of twins suffering from bronchial cancer featuring different histologies (three epidermoidal and one bronchiolar-alveolar) were noted. Statistics show that, in the area where the observed twins were living, anaplastic cancer occurs each year in 0.39% of 53-year-old men. The case of these twins therefore supports the idea of the role of genetic factors in the determination of bronchial cancer.
Nores
J M
JM
Department of Internal Medicine, University of Paris, Hôpital Raymond Poincaré, Garches, France.
Dalayeun
J F
JF
Chebat
J
J
Dieudonne
P
P
Remy
J M
JM
D001984:Bronchial Neoplasms / Q000235:genetics*; D002277:Carcinoma / Q000235:genetics*; D004200:Diseases in Twins; D006801:Humans; D008175:Lung Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014430:Twins, Monozygotic