title: Palliative chemotherapy with CMF after the same adjuvant regimen for breast cancer. The Breast Cancer Study Group.
abstract: BACKGROUND
  The results of palliative chemotherapy with cyclophosphamide, methotrexate and 5-fluorouracil (CMF) in patients with advanced breast cancer who received adjuvant therapy with the same regimen were investigated.
  
  
  RESULTS
  Of 47 patients, 14 (30%) achieved an objective remission (median duration 9.5, range 5-21 months) and 8 (17%) stabilisation of disease (median duration 6, range 3-17 months). Objective remissions were observed in premenopausal as well as in postmenopausal women, in patients with all categories of dominant localisation of disease and regardless of the oestradiol receptor status of the primary tumour or eventual previous endocrine therapy. One of 4 and 13 of 43 patients who started palliative chemotherapy within or later than 12 months after the last adjuvant course obtained an objective remission. The median survival time from start of therapy of all treated patients was 12 (range 1-40) months. Patients with an objective remission or stable disease and patients with progressive disease had a median survival time of 20 (range 6-40) and 6 (range 1-35) months respectively (p < 0.0001).
  
  
  CONCLUSIONS
  Palliative treatment with CMF should not be rejected for patients who have relapsed after adjuvant chemotherapy with the same modality.
authors.affiliation: Department of Medicine, University Hospital, Nijmegen, Netherlands.
authors.forename: M
authors.initials: M
authors.lastname: Gerritsen
authors.forename: D J
authors.initials: DJ
authors.lastname: Wagener
authors.forename: R W
authors.initials: RW
authors.lastname: Schade
authors.forename: L V
authors.initials: LV
authors.lastname: Beex
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000401:mortality; D017024:Chemotherapy, Adjuvant; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D004305:Dose-Response Relationship, Drug; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D008875:Middle Aged; D010166:Palliative Care; D016879:Salvage Therapy; D015996:Survival Rate
chemical_list: D003520:Cyclophosphamide; D005472:Fluorouracil; D008727:Methotrexate