title: Biologic and clinical advances in multiple myeloma.
abstract: Recent advances in our understanding of the cellular and molecular derangements involved in multiple myeloma are beginning to be translated into novel therapeutic approaches. Growth factors, specifically interleukin-6, appear to be critical for disease progression, and interruption of autocrine and paracrine loops has been achieved, with resultant inhibition of myeloma cell growth. Oncogenes, tumor-suppressor genes, and cell-survival genes have all been found to be dysregulated in some myeloma patients. The implications of acquisition of the multidrug resistance phenotype are just beginning to be understood. High-dose therapeutic regimens with bone marrow or peripheral stem-cell rescue are being studied in an attempt to produce a cure. Autologous marrow and peripheral blood stem-cell transplantation are better suited to the older myeloma patient population than is allogeneic marrow transplantation, and have also yielded promising results.
authors.affiliation: Division of Hematology and Oncology, Wayne State University, Harper Hospital, Detroit, Michigan, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Varterasian
mesh_terms: D006801:Humans; D009101:Multiple Myeloma / Q000235:genetics / Q000503:physiopathology / Q000628:therapy