Cicaprost inhibits collagen-induced platelet accumulation in rat lungs for some hours.
A new method is introduced admitting of direct quantification of collagen-induced platelet trapping in the rat lung. The synthetic PG1(2)-mimetics, Iloprost and Cicaprost, are capable of inhibiting the trapping of platelets induced by collagen. The described method has proved to be suited for performing both pharmacodynamic and effectkinetic investigations with inhibitors of collagen-induced platelet trapping.
Nowak
G
G
Max-Planck-Gesellschaft, Research Unit for Pharmacological Haemostaseology, Friedrich Schiller University of Jena, Germany.
Bucha
E
E
D000284:Administration, Oral; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D003094:Collagen / Q000494:pharmacology*; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000494:pharmacology; D005260:Female; D016285:Iloprost / Q000494:pharmacology; D008168:Lung / Q000098:blood supply / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013927:Thrombosis / Q000139:chemically induced / Q000517:prevention & control
D003094:Collagen; D011464:Epoprostenol; D016285:Iloprost; C043867:cicaprost