title: Distribution of SP- and CGRP-like immunoreactive nerve fibers in the lower respiratory tract of neonatal foals: evidence for loss during development.
abstract: The lungs of neonatal foals contain many nerves immunoreactive for substance P and calcitonin gene-related peptide. These nerves are closely associated with the epithelium, bronchial and pulmonary vessels and the airway smooth muscle of all intrathoracic airways, including non-cartilaginous bronchioles. Activation of sensory nerves in the respiratory epithelium could thus potentially affect, via local axon reflexes, vascular and respiratory smooth muscle in neonatal equine airways. Nerves immunoreactive for these peptides are much more widely distributed within the lung than in adult horses; they may thus play a trophic role before birth, or contribute to the post-natal adaptation to breathing.
authors.affiliation: Department of Anatomy, College of Veterinary Medicine, Michigan State University, East Lansing 48824-1314.
authors.forename: I M
authors.initials: IM
authors.lastname: Sonea
authors.forename: R M
authors.initials: RM
authors.lastname: Bowker
authors.forename: N E
authors.initials: NE
authors.lastname: Robinson
authors.forename: R E
authors.initials: RE
authors.lastname: Holland
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000033:anatomy & histology*; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis*; D005260:Female; D006736:Horses / Q000033:anatomy & histology*; D007150:Immunohistochemistry; D008168:Lung / Q000294:innervation*; D008297:Male; D009412:Nerve Fibers / Q000737:chemistry; D013373:Substance P / Q000032:analysis*; D015320:Tachykinins / Q000096:biosynthesis*
chemical_list: D015320:Tachykinins; D013373:Substance P; D015740:Calcitonin Gene-Related Peptide