title: Neurotoxic reaction to lindane in an HIV-seropositive patient. An old medication's new problem.
abstract: Scabies is a common infestation for patients of all ages throughout the world. One of the standard therapies for scabies is 1% lindane lotion. Lindane has been associated with neurotoxic reactions, specifically seizures. We describe a case of a middle-aged adult man with human immunodeficiency virus (HIV) infection who was found to have typical scabies and was treated with a single topical application of lindane. Two hours after the application, the patient experienced a new-onset generalized seizure. We believe that the triad of HIV infection, medications that reduce seizure thresholds, and percutaneous absorption factors, in the aggregate, induced the seizure. We believe that lindane should not be prescribed for patients with HIV infection.
authors.affiliation: Department of Dermatology, State University of New York-Health Science Center at Brooklyn 11203.
authors.forename: B A
authors.initials: BA
authors.lastname: Solomon
authors.forename: S R
authors.initials: SR
authors.lastname: Haut
authors.forename: E M
authors.initials: EM
authors.lastname: Carr
authors.forename: A R
authors.initials: AR
authors.lastname: Shalita
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000818:Animals; D002746:Chlorpromazine / Q000378:metabolism / Q000494:pharmacology; D004285:Dogs; D004347:Drug Interactions; D006679:HIV Seropositivity / Q000150:complications*; D001556:Hexachlorocyclohexane / Q000009:adverse effects* / Q000378:metabolism / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012532:Scabies / Q000150:complications / Q000188:drug therapy*; D012640:Seizures / Q000139:chemically induced* / Q000209:etiology; D012869:Skin Absorption
chemical_list: D001556:Hexachlorocyclohexane; D002746:Chlorpromazine