title: Ibuprofen reduces energy expenditure and acute-phase protein production compared with placebo in pancreatic cancer patients.
abstract: The aim of this study was to investigate the effect of the cyclo-oxygenase inhibitor ibuprofen on the acute-phase protein response and resting energy expenditure (REE) of weight-losing patients with pancreatic cancer. Patients with irresectable pancreatic cancer (n = 16) were treated with either ibuprofen (1200 mg day-1 for 7 days (n = 10) or placebo (n = 6). A group of 17 age-related non-cancer subjects were also studied. Indirect calorimetry, anthropometry, multifrequency bioelectrical impedence analysis and serum C-reactive protein (CRP) estimation were performed immediately before and after treatment. Before treatment, total REE was significantly elevated in the pancreatic cancer patients compared with healthy controls (1499 +/- 71 vs 1377 +/- 58 kcal) (P < 0.02). Following treatment the mean REE of the ibuprofen group fell significantly (1386 +/- 89 kcal) compared with pretreatment values (1468 +/- 99 kcal) (P < 0.02), whereas no change was observed in the placebo group. Serum CRP concentration was also reduced in the ibuprofen-treated group (pre-ibuprofen, 51 mg l-1; post-ibuprofen, 29 mg l-1; P < 0.05). These results suggest that ibuprofen may have a role in abrogating the catabolic processes which contribute to weight loss in patients with pancreatic cancer.
authors.affiliation: University Department of Surgery, Royal Infirmary of Edinburgh, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Wigmore
authors.forename: J S
authors.initials: JS
authors.lastname: Falconer
authors.forename: C E
authors.initials: CE
authors.lastname: Plester
authors.forename: J A
authors.initials: JA
authors.lastname: Ross
authors.forename: J P
authors.initials: JP
authors.lastname: Maingay
authors.forename: D C
authors.initials: DC
authors.lastname: Carter
authors.forename: K C
authors.initials: KC
authors.lastname: Fearon
mesh_terms: D000209:Acute-Phase Proteins / Q000096:biosynthesis*; D000818:Animals; D002097:C-Reactive Protein / Q000096:biosynthesis; D004734:Energy Metabolism / Q000187:drug effects*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000378:metabolism*; D011817:Rabbits
chemical_list: D000209:Acute-Phase Proteins; D002097:C-Reactive Protein; D007052:Ibuprofen