title: Genetic markers: association study in migraine.
abstract: Eleven genetic markers were typed in 112 unrelated patients with migraine (50 with aura, 62 without aura) and compared with a random sample of healthy individuals. No significant differences were found for the ABO and Rh systems, acid phosphatase 1, phosphoglucomutase 1, adenosine deaminase, haptoglobin, transferrin, alpha-1-antitrypsin, and D1S80. Strong associations between the group of patients with migraine and group-specific component GC 1F-1F and esterase-D ESD 2-2 phenotypes were observed. These associations raise the possibility that a molecular genetic factor for migraine may exist in or near the Group Component (chromosome 4) and Esterase D (chromosome 13) loci, and represent a first comprehensive step in the eventual localization and isolation of the migraine genes.
authors.affiliation: Department of Neurology, Hospital General de Galicia Clínico Universitario, Santiago de Compostela, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Pardo
authors.forename: A
authors.initials: A
authors.lastname: Carracedo
authors.forename: I
authors.initials: I
authors.lastname: Muñoz
authors.forename: J
authors.initials: J
authors.lastname: Castillo
authors.forename: M
authors.initials: M
authors.lastname: Lema
authors.forename: M
authors.initials: M
authors.lastname: Noya
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D005260:Female; D005819:Genetic Markers; D006801:Humans; D008297:Male; D008875:Middle Aged; D008881:Migraine Disorders / Q000097:blood / Q000235:genetics*; D010641:Phenotype
chemical_list: D005819:Genetic Markers