Autoimmune paraneoplastic cerebellar degeneration: immunohistological localization of antibody-binding sites.
Sera from 3 patients with breast or ovarian tumors and paraneoplastic cerebellar degeneration (PCD) contained anti-Purkinje cell antibodies (PCAbs) which also bind to other neurons on frozen sections of adult rodent brain. PCAbs tested on new-born rodent (rabbit, rat, mouse) brain tissue detected only oligodendrocyte-like cells (ODLC) in the white matter and allowed us to speculate on the nature of the antigenic structure in the neuronal cytoplasm. All these PCAbs appear histochemically identical and recognize antigens which belong to so-called "Yo" proteins.
Nardelli
E
E
Dipartimento di Scienze Neurologiche e della Visione, Policlinico Borgo Roma, Università degli Studi di Verona, Italy.
Currò-Dossi
B
B
Rizzuto
N
N
Graus
F
F
D000230:Adenocarcinoma / Q000276:immunology* / Q000473:pathology; D000328:Adult; D000818:Animals; D001284:Atrophy; D001323:Autoantibodies / Q000032:analysis; D001324:Autoantigens; D001327:Autoimmune Diseases / Q000276:immunology* / Q000473:pathology; D001666:Binding Sites, Antibody / Q000276:immunology*; D001921:Brain / Q000276:immunology / Q000473:pathology; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology; D002526:Cerebellar Diseases / Q000276:immunology* / Q000473:pathology; D002531:Cerebellum / Q000276:immunology / Q000473:pathology; D004268:DNA-Binding Proteins / Q000276:immunology; D000939:Epitopes / Q000276:immunology; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008279:Magnetic Resonance Imaging; D051379:Mice; D008875:Middle Aged; D009363:Neoplasm Proteins / Q000276:immunology; D009410:Nerve Degeneration / Q000276:immunology*; D009419:Nerve Tissue Proteins; D009836:Oligodendroglia / Q000276:immunology / Q000473:pathology; D010051:Ovarian Neoplasms / Q000276:immunology* / Q000473:pathology; D011689:Purkinje Cells / Q000276:immunology / Q000473:pathology; D011817:Rabbits; D051381:Rats
D001323:Autoantibodies; D001324:Autoantigens; C063762:CDR1 protein, human; C095184:CDR2 protein, human; D004268:DNA-Binding Proteins; D000939:Epitopes; D009363:Neoplasm Proteins; D009419:Nerve Tissue Proteins