title: Observations on aflatoxins and the liver status of Ghanaian subjects.
abstract: To find out if the presumed intake of dietary aflatoxins (AFB1 and AFG1) has adverse effect on the liver of Ghanaians, the toxins were measured in serum, urine and faecal specimens obtained from a group of apparently healthy Ghanaian adults. Liver status of the subjects was monitored with serum alphafeto protein (AFP), alpha-l-antitrypsin (AAT) and direct: total bilirubin ratio. Aflatoxin G1, AFB1 and AFQ1, AFM1 (both metabolites of AFB1) were detected in one or more of the body specimens in 35% of the subjects (AFB1+ group). Sixty-five percent (26 out of 40) of the subjects had only AFG1 in their body specimens (AFB1- group). Serum levels of AFP (greater than 20.0 ng/ml, AAT (greater than 170.0 mg/dl) and direct: total bilirubin ratio (greater than 0.5) which indicate absence of predisposition to liver cancer in all the subjects but suggestive of liver inflammation were noted in both the AFB1+ and AFB1- subjects. The pattern of distribution of the aflatoxins in the subjects suggests that the suspected liver inflammation may involve other factors and may not only be due to the present intake levels of aflatoxins.
authors.affiliation: Clinical Pathology Unit Noguchi Memorial Institute for Medical Research University of Ghana, Legon.
authors.forename: N A
authors.initials: NA
authors.lastname: Ankrah
authors.forename: T
authors.initials: T
authors.lastname: Rikimaru
authors.forename: F A
authors.initials: FA
authors.lastname: Ekuban
mesh_terms: D000328:Adult; D000348:Aflatoxins / Q000009:adverse effects* / Q000032:analysis; D000368:Aged; D001663:Bilirubin / Q000097:blood; D056486:Chemical and Drug Induced Liver Injury / Q000097:blood / Q000209:etiology* / Q000378:metabolism* / Q000652:urine; D004032:Diet / Q000009:adverse effects*; D004034:Diet Surveys; D005243:Feces / Q000737:chemistry; D005260:Female; D005869:Ghana; D006801:Humans; D008099:Liver / Q000187:drug effects; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D000515:alpha 1-Antitrypsin / Q000378:metabolism; D000509:alpha-Fetoproteins / Q000378:metabolism
chemical_list: D000348:Aflatoxins; D000515:alpha 1-Antitrypsin; D000509:alpha-Fetoproteins; D001663:Bilirubin