Effect of RANTES on intracellular expression of EG2 antigen in eosinophils.
RANTES, which is released from thrombin-stimulated platelets, is a member of the 8-kDa cytokine family that has been shown to possess chemotactic activity for eosinophils. The effect of RANTES on the intracellular expression of EG2 antigen in eosinophils was examined in this study. RANTES augmented the intracellular expression of EG2 antigen in eosinophils. These findings suggest that RANTES not only modulates the chemotactic activity of eosinophils but also intensifies the function of eosinophil activation.
Kakazu
T
T
Fourth Department of Internal Medicine, Kinki University, Osaka, Japan.
Chihara
J
J
Saito
A
A
Higashimoto
I
I
Yamamoto
T
T
Kurachi
D
D
Nakajima
S
S
D001249:Asthma / Q000473:pathology; D001798:Blood Proteins / Q000378:metabolism*; D018946:Chemokine CCL5 / Q000494:pharmacology*; D002630:Chemotactic Factors / Q000494:pharmacology*; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000276:immunology / Q000378:metabolism*; D006801:Humans; D012260:Ribonucleases
D001798:Blood Proteins; D018946:Chemokine CCL5; D002630:Chemotactic Factors; D047091:Eosinophil Granule Proteins; D012260:Ribonucleases