title: Does the transcription factor c-ets1 take part in the regulation of angiogenesis and tumor invasion?
abstract: The c-ets1 proto-oncogene encodes a transcription factor that binds a GGAA/T purine rich core DNA sequence. During normal as well as pathological development, the expression of c-ets1 is associated with the occurrence of invasive processes, either in invading cells or in the invaded tissue. Cellular regulatory sequences responsive to the c-Ets1 proteins include a urokinase-type plasminogen activator (u-PA) gene enhancer, the stromelysin-1 and the collagenase-1 gene promoters. Since invasive processes are thought to require the remodeling of the extra-cellular matrix, we investigate the relationships between c-Ets1 and the expression pattern of transcripts encoding these matrix degrading proteases, in embryos and in solid tumors.
authors.affiliation: Laboratoire d'Oncologie Moléculaire, CNRS-URA 1160, Institut Pasteur de Lille, France.
authors.forename: B
authors.initials: B
authors.lastname: Vandenbunder
authors.forename: N
authors.initials: N
authors.lastname: Wernert
authors.forename: C
authors.initials: C
authors.lastname: Queva
authors.forename: X
authors.initials: X
authors.lastname: Desbiens
authors.forename: D
authors.initials: D
authors.lastname: Stehelin
mesh_terms: D009389:Neovascularization, Pathologic / Q000503:physiopathology; D050784:Proto-Oncogene Protein c-ets-1; D011518:Proto-Oncogene Proteins / Q000235:genetics* / Q000378:metabolism*; D050783:Proto-Oncogene Proteins c-ets; D011519:Proto-Oncogenes / Q000502:physiology*; D014157:Transcription Factors / Q000235:genetics* / Q000378:metabolism
chemical_list: D050784:Proto-Oncogene Protein c-ets-1; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors