[Disorders of interferon status in bronchopulmonary diseases in children living under conditions of elevated background radiation].
Impairments in the interferon status of children with chronic and recurring diseases of the respiratory organs were investigated and its correction was shown possible with the use of alpha 2-interferon (reaferon). Suppression of the interferon-producing capacity of the immunocytes was observed in all the cases of the disease aggravation. The level of the suppression correlated with the severity of the infection. In the patients affected by radiation the suppression of the interferonogenesis was more marked. However, in these cases no dependence of the detected impairments in the interferon status on the level of the radiation pollution of the territory of the children residence was shown. The inclusion of reaferon to the basal therapy resulted in a significant increase of the alpha-interferon production in the cases of bronchial asthma and asthmatic bronchitis as well as its recovery to the normal in the cases of recurring bronchitis and chronic pneumonia. In all the cases of bronchopulmonary diseases only a tendency towards normalization of the alpha-interferon indices was recorded.
Iakovenko
L F
LF
Spivak
N Ia
NIa
Ganova
L A
LA
Krivokhatskaia
L D
LD
Mazalevskiĭ
A F
AF
Radchenko
N A
NA
Ershov
F I
FI
D001982:Bronchial Diseases / Q000097:blood / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D004782:Environmental Health; D006801:Humans; D007370:Interferon Type I / Q000627:therapeutic use*; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D007372:Interferons / Q000096:biosynthesis* / Q000097:blood; D007962:Leukocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008171:Lung Diseases / Q000097:blood / Q000188:drug therapy*; D011210:Power Plants; D018788:Radioactive Hazard Release; D011994:Recombinant Proteins; D012008:Recurrence; D014455:Ukraine
D007370:Interferon Type I; D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D007372:Interferons