title: Effect of extracorporeal life support on cerebral blood flow, metabolism and electrophysiology in normothermic cats.
abstract: OBJECTIVE
  Recently, extracorporeal life support (ECLS) by venoarterial bypass perfusion has been recommended for the treatment of refractory respiratory and/or cardiac failure but the safety of this application for the brain is not yet established. Therefore, the effects of normothermic ECLS on cerebral blood flow, metabolism and electrophysiology were studied in cats with total arrest of cardiopulmonary circulation.
  
  
  METHODS
  An extracorporeal circulation (ECC) system, consisting of a roller pump, a membrane oxygenator and a heat exchanger, was connected to the circulation of cat by cannulae inserted via the jugular vein and femoral vessels. After 2 h ECLS brains were frozen in situ and investigated for changes in regional metabolism.
  
  
  RESULTS
  During 2 h ECC hematocrit declined from 37 +/- 7% to 21 +/- 10% (means +/- SD, p < 0.05), cerebral blood flow decreased to 73 +/- 14% of control (p < 0.05) and cerebral oxygen delivery to 46 +/- 13% of control (p < 0.05) although arterial blood pressure and bypass flow rate did not change. Plasma lactate increased from 0.8 +/- 0.3 to 9.2 +/- 4.2 mumol/ml (p < 0.05), and brain tissue lactate from 2.3 +/- 0.9 to 10.6 +/- 2.7 mumol/g (p < 0.05). Hematocrit correlated positively with cerebral oxygen delivery (r = 0.86, p < 0.001).
  
  
  CONCLUSIONS
  These data demonstrate that ECLS is associated with reduced cerebral oxygen delivery and may cause brain hypoxia despite normal blood pressure. This complication may contribute to the high incidence of neurological disturbances after prolonged ECLS.
authors.affiliation: Max-Planck-Institut für Neurologische Forschung, Köln, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Iijima
authors.forename: T
authors.initials: T
authors.lastname: Back
authors.forename: K A
authors.initials: KA
authors.lastname: Hossmann
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism*; D001923:Brain Chemistry; D002415:Cats; D002560:Cerebrovascular Circulation; D004594:Electrophysiology; D005069:Evaluation Studies as Topic; D015199:Extracorporeal Membrane Oxygenation / Q000295:instrumentation / Q000379:methods*; D006323:Heart Arrest / Q000378:metabolism* / Q000628:therapy*; D007773:Lactates / Q000032:analysis; D019344:Lactic Acid; D010101:Oxygen Consumption; D013997:Time Factors
chemical_list: D007773:Lactates; D019344:Lactic Acid