title: Antimicrobial screening of zinc in the absence or presence of oleoresins and various resin acids.
abstract: Zinc and oleoresins are the main components of several wound dressings, and are also frequently used in root canal treatment. The in vitro antibacterial effects of zinc, six highly purified resin acids and two commercial oleoresins alone or combined in varying proportions were analysed. Oleoresins are composed of approximately 90% resin acids and the most common acids were included in this study. The antibacterial activity of the various chemicals was estimated using a Bioscreen robot analyser, which allowed 24 h kinetic documentation of bacterial growth. The bacteria employed were reference species commonly occurring on human skin or of oral origin. Zinc as well as the oleoresins and the pure resin acids all showed antibacterial activity when present in growth media, but the sensitivity of the bacteria varied. The presence of resin acids and oleoresins increased the antibacterial effect of zinc to varying degrees depending on the combination and the bacterial species tested. The results of the present study indicate that zinc, resin acids, or oleoresins alone, as well as combined, show antibacterial activity against selected aerobic Gram-positive and anaerobic Gram-negative bacteria.
authors.affiliation: Department of Periodontology, University of Umeå, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Johansson
authors.forename: B
authors.initials: B
authors.lastname: Sunzel
authors.forename: S E
authors.initials: SE
authors.lastname: Holm
authors.forename: T
authors.initials: T
authors.lastname: Söderberg
authors.forename: R
authors.initials: R
authors.lastname: Gref
mesh_terms: D045784:Abietanes; D001419:Bacteria / Q000187:drug effects*; D004224:Diterpenes / Q000494:pharmacology*; D004357:Drug Synergism; D006801:Humans; D010616:Phenanthrenes / Q000494:pharmacology*; D010936:Plant Extracts / Q000494:pharmacology*; D015032:Zinc / Q000494:pharmacology*
chemical_list: D045784:Abietanes; D004224:Diterpenes; D010616:Phenanthrenes; D010936:Plant Extracts; C018620:oleoresins; C013913:dehydroabietic acid; C002470:podocarpic acid; D015032:Zinc; C023710:abietic acid