Hormone replacement therapy, sleep quality and psychological wellbeing.
OBJECTIVE
To examine the effect of hormone replacement therapy upon sleep quality and duration in postmenopausal women.


METHODS
Randomised, single-blind, placebo-controlled trial.


METHODS
Sleep research laboratory.


METHODS
Thirty-three healthy postmenopausal women.


METHODS
Continuous 0.625 mg conjugated equine oestrogens with 0.15 mg cyclic norgestrel taken for 12 days per 28 day cycle.


METHODS
Occurrence of vasomotor symptoms, polysomnographic sleep stage measures, Stanford sleepiness questionnaire, Crown-Crisp experiential index and the cognitive failures questionnaire.


RESULTS
Hormone replacement therapy results in an improvement in menopausal symptoms but not in parameters of sleep quality. Despite this, certain measures of psychological wellbeing showed significant improvement in the hormone replacement therapy group.


CONCLUSIONS
Hormone replacement therapy results in a measurable improvement in physical and psychological welfare, the latter being independent of improvement in sleep quality.
Purdie
D W
DW
Menopause Clinic, Princess Royal Hospital (Royal Hull Hospitals NHS Trust), Kingston Upon Hull, UK.
Empson
J A
JA
Crichton
C
C
Macdonald
L
L
D000328:Adult; D000339:Affect / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects; D015914:Estrogen Replacement Therapy; D005260:Female; D006801:Humans; D008603:Mental Health; D008875:Middle Aged; D009644:Norgestrel / Q000627:therapeutic use; D016037:Single-Blind Method; D012890:Sleep / Q000187:drug effects*; D014666:Vasomotor System / Q000187:drug effects
D009644:Norgestrel