Expression of platelet-derived endothelial cell growth factor/thymidine phosphorylase in human breast cancer.
We have investigated the expression of platelet-derived endothelial-cell growth factor/thymidine phosphorylase (PD-ECGF/dThdPase) in human breast-cancer tissues by the immunocytochemical method using anti-PD-ECGF/dThdPase monoclonal antibody. Out of 100 invasive-ductal-carcinoma tissue samples, 39 (39%) were evaluated as PD-ECGF/dThdPase-positive. The expression of PD-ECGF/dThdPase was identified mainly in the cytoplasma of tumor cells. The expression of PD-ECGF/dThdPase was significantly associated with the microvessel density assessed by immunostaining to factor-VIII-related-antigen (p < 0.05). However, there was no correlation between expression of PD-ECGF/dThdPase and menopausal status, tumor size, axillary lymph-node metastases, hormone-receptor status, epidermal-growth-factor receptor, or erb-B-2-protein and p53-protein expression. We suggest that expression of PD-ECGF/dThdPase plays an important role in the promotion of angiogenesis in human breast cancer.
Toi
M
M
Department of Surgery, Tokyo Metropolitan Komagome Hospital, Japan.
Hoshina
S
S
Taniguchi
T
T
Yamamoto
Y
Y
Ishitsuka
H
H
Tominaga
T
T
D000911:Antibodies, Monoclonal; D001943:Breast Neoplasms / Q000098:blood supply / Q000201:enzymology / Q000378:metabolism*; D018270:Carcinoma, Ductal, Breast / Q000098:blood supply / Q000201:enzymology / Q000378:metabolism*; D016009:Chi-Square Distribution; D016228:Endothelial Growth Factors / Q000378:metabolism*; D005260:Female; D015971:Gene Expression Regulation, Enzymologic; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D007150:Immunohistochemistry; D009389:Neovascularization, Pathologic / Q000201:enzymology / Q000378:metabolism*; D010982:Platelet-Derived Growth Factor / Q000378:metabolism*; D013939:Thymidine Phosphorylase / Q000096:biosynthesis*
D000911:Antibodies, Monoclonal; D016228:Endothelial Growth Factors; D010982:Platelet-Derived Growth Factor; D013939:Thymidine Phosphorylase