An improvement of the endocrine diagnosis by high-performance liquid chromatography.
The assessment of catecholamines (NE, E), essential metabolites (VMA, HVA) and serotonergic metabolite 5HIIA in urine by HPLC with UV detection is of interest for clinical diagnosis concerning HTA, pheochromocytoma, neuroblastoma, carcinoid syndrome, hypotension, etc. In the same urine sample one can detect (following preliminary steps) by HPLC the above--mentioned biochemical parameters with good reproducibility and sensitivity.
Stefănescu
A M
AM
C. I. Parhon Institute of Endocrinology, Bucharest, Romania.
D000310:Adrenal Gland Neoplasms / Q000652:urine; D000328:Adult; D002395:Catecholamines / Q000652:urine*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002855:Chromatography, Thin Layer; D004700:Endocrine System Diseases / Q000175:diagnosis* / Q000652:urine; D004837:Epinephrine / Q000652:urine; D006719:Homovanillic Acid / Q000652:urine; D006801:Humans; D006897:Hydroxyindoleacetic Acid / Q000652:urine; D008303:Malignant Carcinoid Syndrome / Q000652:urine; D008875:Middle Aged; D009447:Neuroblastoma / Q000652:urine; D009638:Norepinephrine / Q000652:urine; D010673:Pheochromocytoma / Q000652:urine; D014642:Vanilmandelic Acid / Q000652:urine
D002395:Catecholamines; D006897:Hydroxyindoleacetic Acid; D014642:Vanilmandelic Acid; D009638:Norepinephrine; D006719:Homovanillic Acid; D004837:Epinephrine