Susceptibility in cell culture of feline immunodeficiency virus to eighteen antiviral agents.
The in-vitro susceptibilities of two strains of feline immunodeficiency virus to 18 antiviral agents were determined in two cell lines. In terms of inhibiting p24 antigen production, the nucleoside-analogue reverse transcriptase inhibitors were the most effective compounds. Inhibition was also observed with aurintricarboxylic acid, phosphonoformate and butyldeoxynorjirimycin, but not with the other agents tested.
Smyth
N R
NR
Department of Veterinary Clinical Science and Animal Husbandry, University of Liverpool, UK.
McCracken
C
C
Gaskell
R M
RM
Cameron
J M
JM
Coates
J A
JA
Gaskell
C J
CJ
Hart
C A
CA
Bennett
M
M
D000818:Animals; D000956:Antigens, Viral / Q000096:biosynthesis; D000998:Antiviral Agents / Q000494:pharmacology* / Q000633:toxicity; D002415:Cats; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D006801:Humans; D016089:Immunodeficiency Virus, Feline / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects / Q000821:virology; D008826:Microbial Sensitivity Tests; D018894:Reverse Transcriptase Inhibitors
D000956:Antigens, Viral; D000998:Antiviral Agents; D018894:Reverse Transcriptase Inhibitors