title: Calcium channel subtypes and intracellular calcium stores modulate electric field-stimulated and -oriented nerve growth.
abstract: In culture, embryonic spinal neurites from Xenopus laevis show striking growth responses to steady dc electric fields, at a time when endogenous electric fields of similar size impinge on the developing nervous system. A high proportion of cultured neurites reorient, with both turning and branching directed cathodally. Neurite growth rates are increased and growth is differential (faster cathodally than anodally). Voltage-dependent calcium channels and calcium release from intracellular stores are shown to control these events. However, the pharmacological sensitivities of these phenomena differ, indicating different control mechanisms.
authors.affiliation: Department of Biomedical Sciences, Marischal College, University of Aberdeen, Scotland.
authors.forename: R
authors.initials: R
authors.lastname: Stewart
authors.forename: L
authors.initials: L
authors.lastname: Erskine
authors.forename: C D
authors.initials: CD
authors.lastname: McCaig
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D015220:Calcium Channels / Q000502:physiology*; D002478:Cells, Cultured; D004558:Electric Stimulation; D005260:Female; D016501:Neurites / Q000502:physiology*; D014982:Xenopus laevis
chemical_list: D002121:Calcium Channel Blockers; D015220:Calcium Channels; D002118:Calcium