title: Relationship between the diuretic effect of radiocontrast media and their ability to increase renal vascular resistance.
abstract: The relationship between diuresis and natriuresis induced by radiocontrast media (RCM) and their renal haemodynamic effects were investigated. The effects of the iso-osmolar iotrolan and the hyperosmolar diatrizoate on the renal vascular resistance (RVR) were studied in the filtering and non-filtering variants of the isolated perfused rat kidney (IPRK) preparation. In the non-filtering model, no tubular regulatory process can be activated. The effect of diatrizoate on the RVR of the filtering IPRK in the presence of fursemide (0.3 mmol l-1) an inhibitor of the tubuloglomerular feedback (TGF) was also investigated. There was no significant difference (p > 0.05) in the response of the filtering (n = 6) and non-filtering (n = 6) IPRK to iotrolan. The induced reduction in the renal perfusate flow (RPF) by iotrolan was 20.5 +/- 3.05% and 22.9 +/- 3.03%, respectively. The reduction in the RPF which was observed with diatrizoate in the non-filtering IPRK (n = 5, 17.5 +/- 3.04%) was significantly less (p < 0.05) in comparison to that of the filtering IPRK (n = 6, 26.9 +/- 4.28%). In the frusemide experiments, a reduction in the RPF comparable to that of the non-filtering kidney was observed (n = 5, 13.7 +/- 4.34%). This study demonstrates that the renal vascular effect of diatrizoate is partially dependent on the TGF response. No tubular regulatory mechanism was accountable for the haemodynamic effect of iotrolan. The activation of the tubular response is osmolarity dependent.
authors.affiliation: Department of Diagnostic Imaging, Northern General Hospital NHS Trust, Sheffield, UK.
authors.forename: S K
authors.initials: SK
authors.lastname: Morcos
authors.forename: P W
authors.initials: PW
authors.lastname: Brown
authors.forename: S
authors.initials: S
authors.lastname: Oldroyd
authors.forename: A M
authors.initials: AM
authors.lastname: el Nahas
authors.forename: J
authors.initials: J
authors.lastname: Haylor
mesh_terms: D000818:Animals; D003287:Contrast Media / Q000494:pharmacology*; D003973:Diatrizoate / Q000494:pharmacology; D004231:Diuresis / Q000187:drug effects*; D005246:Feedback; D005665:Furosemide / Q000494:pharmacology; D066298:In Vitro Techniques; D007668:Kidney / Q000098:blood supply*; D008297:Male; D009994:Osmolar Concentration; D051381:Rats; D017208:Rats, Wistar; D014283:Triiodobenzoic Acids / Q000494:pharmacology; D014655:Vascular Resistance / Q000187:drug effects*
chemical_list: D003287:Contrast Media; D014283:Triiodobenzoic Acids; D003973:Diatrizoate; C033300:iotrolan; D005665:Furosemide