title: Hepatitis C virus type I(1a) in northern China.
abstract: Twenty-four patients with hepatitis C virus (HCV) antibody from the Chinese North Western province of Jilin were further analysed by the immunoblot assay-2 (RIBA-2), reverse transcription-polymerase chain reaction (RT-PCR) for serum HCV RNA detection, and direct sequence-genotyping. Good concordance was found between the original second generation HCV antibody ELISA, RIBA-2, and serum HCV RNA. The occurrence of genotype I (1a), a genotype not previously reported in China, is described in 5(20.8%) of 24 cases, in association with genotypes II(1b) and III(2a) which were found in 16(66.7%) and 3(12.5%) of 24 cases, respectively. Imported blood products were unlikely to be the source of infection with genotype I (1a) but could not be definitively ruled out.
authors.affiliation: Department of Medicine, St. Mary's Hospital Medical School, Imperial College of Science, Technology and Medicine, London, United Kingdom.
authors.forename: J
authors.initials: J
authors.lastname: Niu
authors.forename: U
authors.initials: U
authors.lastname: Kumar
authors.forename: Y
authors.initials: Y
authors.lastname: Pan
authors.forename: Y
authors.initials: Y
authors.lastname: Liu
authors.forename: Q
authors.initials: Q
authors.lastname: Zhan
authors.forename: H
authors.initials: H
authors.lastname: Thomas
authors.forename: J
authors.initials: J
authors.lastname: Monjardino
mesh_terms: D001483:Base Sequence; D002681:China; D005838:Genotype; D016174:Hepacivirus / Q000145:classification / Q000235:genetics*; D006508:Hepatitis Antibodies / Q000032:analysis; D006526:Hepatitis C / Q000276:immunology / Q000821:virology*; D018937:Hepatitis C Antibodies; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis; D014158:Transcription, Genetic
chemical_list: D006508:Hepatitis Antibodies; D018937:Hepatitis C Antibodies; D012367:RNA, Viral