Recombinant interleukin-1 beta inhibits gastric acid secretion by activation of central sympatho-adrenomedullary outflow in rats.
The inhibitory mechanism of gastric acid secretion induced by human recombinant interleukin-1 beta was investigated in bilaterally vagotomized, urethane-anesthetized rats. Intracerebroventricular administration of interleukin-1 beta (10, 50 and 100 ng/animal) dose dependently inhibited the gastric acid secretion induced by electrical stimulation of the vagus nerve at 3 Hz. Inhibition of gastric acid secretion induced by interleukin-1 beta (50 ng/animal) was abolished both by splanchnectomy and by phentolamine (5 mg/kg i.m.). Greater splanchnic nerves ramify into the adrenal branch and gastric sympathetic preganglionic branch. The interleukin-1 beta (50 ng/animal)-induced inhibition was also abolished by intracerebroventricular pretreatment with indomethacin (500 micrograms/animal), while pretreatment with the same dose of this reagent by the intraperitoneal route was without effect. These results suggest that centrally administered interleukin-1 beta induces a prostaglandin-mediated central excitation of the sympatho-adrenomedullary system, and the resultant activation of gastric alpha-adrenoceptors inhibits the vagally stimulated gastric acid secretion in rats.
Yokotani
K
K
Department of Pharmacology, Kochi Medical School, Japan.
Okuma
Y
Y
Osumi
Y
Y
D000313:Adrenal Medulla / Q000187:drug effects / Q000502:physiology*; D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology; D000758:Anesthesia; D000818:Animals; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D007276:Injections, Intraventricular; D007375:Interleukin-1 / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male; D010646:Phentolamine / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D014520:Urethane; D014630:Vagus Nerve / Q000502:physiology
D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D007375:Interleukin-1; D011994:Recombinant Proteins; D014520:Urethane; D011433:Propranolol; D010646:Phentolamine