Determination of inflammatory markers in allergic reactions to drugs.
Serum tryptase (Tryp) and eosinophil cationic protein (ECP) and urine N-methylhistamine (N-MH) were quantitated in a group of 13 subjects who had experienced immediate allergic reactions to different drugs. Results indicated that both Tryp and N-MH were involved and the levels were related to the severity of the reaction. Results of serum ECP levels failed to provide relevant information concerning the participation of eosinophils in immediate reactions to drugs.
Moreno
F
F
Research Unit for Allergic Diseases, Carlos Haya Hospital, Malaga, Spain.
Blanca
M
M
Fernandez
J
J
Ferrer
A
A
Mayorga
C
C
del Caño
A
A
Aguilar
F
F
Juarez
C
C
Garcia
J
J
D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001798:Blood Proteins / Q000378:metabolism* / Q000652:urine; D053818:Chymases; D004342:Drug Hypersensitivity / Q000097:blood / Q000378:metabolism* / Q000652:urine; D047091:Eosinophil Granule Proteins; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism* / Q000652:urine; D008297:Male; D008761:Methylhistamines / Q000378:metabolism* / Q000652:urine; D008875:Middle Aged; D012260:Ribonucleases; D012680:Sensitivity and Specificity; D012697:Serine Endopeptidases / Q000097:blood / Q000378:metabolism*; D013997:Time Factors; D053802:Tryptases
D015415:Biomarkers; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D008761:Methylhistamines; D012260:Ribonucleases; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases; C048140:N-methylhistamine