Disseminated intravascular coagulation associated with granulocyte colony-stimulating factor therapy in a child with human immunodeficiency virus infection.
We report a case of disseminated intravascular coagulopathy, apparently caused by exposure to granulocyte colony-stimulating factor (G-CSF). The medical records of patients treated for more than 30 consecutive days with subcutaneously administered G-CSF were reviewed for the occurrence of thrombocytopenia or coagulation abnormalities. New-onset thrombocytopenia with a platelet count less than 100 x 10(9) cells/L (< 100,000 cells/mm3) developed in 9 of 23 patients (39%) after a median of 11 weeks of treatment with G-CSF at dosages between 1 and 10 micrograms/kg per day.
Mueller
B U
BU
Pediatric Branch, National Cancer Institute, Bethesda, MD 20892, USA.
Burt
R
R
Gulick
L
L
Jacobsen
F
F
Pizzo
P A
PA
Horne
M
M
D000293:Adolescent; D000328:Adult; D000998:Antiviral Agents / Q000627:therapeutic use; D001779:Blood Coagulation Factors / Q000187:drug effects; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D004211:Disseminated Intravascular Coagulation / Q000097:blood / Q000209:etiology*; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage / Q000009:adverse effects*; D015658:HIV Infections / Q000628:therapy*; D006467:Hemophilia A / Q000628:therapy; D006801:Humans; D007223:Infant; D007279:Injections, Subcutaneous; D007958:Leukocyte Count; D008297:Male; D010976:Platelet Count; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology
D000998:Antiviral Agents; D001779:Blood Coagulation Factors; D016179:Granulocyte Colony-Stimulating Factor