Postnatal modulation of hepatic biotransformation system enzymes via translactational exposure of F1 mouse pups to turmeric and curcumin.
The potential for the transfer of active principle(s) of turmeric (Curcuma longa L.) and curcumin (major pigment in turmeric) via translactational route and its modulatory influence on the hepatic biotransformation system enzymes in the lactating dams and their suckling offspring was assessed. Turmeric (4 g/kg b.w. per day) and curcumin (0.4 g/kg b.w. per day) induced significant (P < 0.01) increase in the hepatic levels of glutathione S-transferase (GST) and acid soluble sulfhydryl (-SH) after 14 or 21 days treatment in lactating dams and translactationally exposed F1 pups. However the lower dose of curcumin (0.2 g/kg b.w. per day) could modulate hepatic GST activity (P < 0.05) and -SH (P < 0.01) only after 21 days of treatment in dams and pups. Cytochrome b5 and cytochrome P450 levels were significantly elevated (P < 0.05) in the dams as well as their suckling pups of both 14 and 21 days age groups at the selected dose levels of turmeric (4 g/kg b.w.) and curcumin (0.4 g/kg b.w.). The induction in hepatic biotransformation system enzymes in lactating dams and F1 progeny suggests the passage of active constituents and/or metabolites of turmeric and curcumin via the translactational route.
Singh
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Human Genetics Laboratory, School of Life Sciences, Jawahalal Nehru University, New Delhi, India.
Singh
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SP
Bamezai
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D000818:Animals; D000833:Animals, Suckling; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology*; D001711:Biotransformation; D003474:Curcumin / Q000494:pharmacology*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D015786:Cytochromes b5 / Q000378:metabolism; D005260:Female; D005982:Glutathione Transferase / Q000378:metabolism; D007774:Lactation; D008099:Liver / Q000033:anatomy & histology / Q000201:enzymology*; D008297:Male; D051379:Mice; D008892:Milk / Q000737:chemistry; D009929:Organ Size; D013438:Sulfhydryl Compounds / Q000378:metabolism
D000972:Antineoplastic Agents, Phytogenic; D013438:Sulfhydryl Compounds; D015786:Cytochromes b5; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase; D003474:Curcumin