CM101, a polysaccharide antitumor agent, does not inhibit wound healing in murine models.
CM101 (previously called GBS toxin), a new anticancer polysaccharide that induces inflammatory reactions in neovasculature of tumors, does not cause similar reactions in neovasculature of healing wounds. It appears that treatment with CM101 will not interfere with normal wound healing in cancer patients.
Quinn
T E
TE
Department of Biochemistry, Vanderbilt University School of Medicine, Nashville, Tennessee 37232-0146, USA.
Thurman
G B
GB
Sundell
A K
AK
Zhang
M
M
Hellerqvist
C G
CG
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002329:Carmine; D004195:Disease Models, Animal; D004343:Drug Implants; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D009389:Neovascularization, Pathologic / Q000188:drug therapy; D011135:Polysaccharides, Bacterial / Q000494:pharmacology*; D011142:Polyvinyl Alcohol; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D000970:Antineoplastic Agents; D004343:Drug Implants; D011135:Polysaccharides, Bacterial; C032263:streptococcal polysaccharide type III group B; D011142:Polyvinyl Alcohol; D002329:Carmine; D008775:Methylprednisolone