title: The change in the distribution of Tc-99m human serum albumin radioaerosols in asthma after a 1-week course of corticosteroid inhalation treatment.
abstract: This study evaluated the effects of corticosteroid inhalation on the deposition pattern of Tc-99m HSA radioaerosols in 24 patients with asthma. The homogeneous degree of depositing radioaerosol was quantitatively evaluated using a modified standard score system over both lungs. The baseline scores were calculated before inhalation therapy of 0.05 mg beclomethasone dipropionate four times daily for 1 week. The studies were then repeated after treatment to evaluate the effects of inhalation therapy. After treatment, the scores decreased in 16 of 24 cases (67%), which means that the degree of the bronchial obstruction decreased. The statistical results revealed significant differences in the total homogeneity score (P < 0.001) before and after therapy. Thus, a 1-week course of beclomethasone dipropionate inhalation therapy improves the bronchial obstruction in asthma patients as shown by the quantitative homogeneity score system of the Tc-99m HSA radioaerosol inhalation lung scintigraphy.
authors.affiliation: Department of Nuclear Medicine, Chung-Shan Medical College Hospital, Taiwan, Republic of China.
authors.forename: S P
authors.initials: SP
authors.lastname: Changlai
authors.forename: C H
authors.initials: CH
authors.lastname: Kao
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: W Y
authors.initials: WY
authors.lastname: Lin
authors.forename: J L
authors.initials: JL
authors.lastname: Lan
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000008:administration & dosage* / Q000627:therapeutic use; D001249:Asthma / Q000000981:diagnostic imaging*; D001507:Beclomethasone / Q000008:administration & dosage* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin / Q000008:administration & dosage
chemical_list: D000336:Aerosols; D018927:Anti-Asthmatic Agents; D013668:Technetium Tc 99m Aggregated Albumin; D001507:Beclomethasone