Thalamocortical projections activated by phrenic nerve afferents in the cat.
This study identified thalamocortical projections activated by respiratory afferents. Cortical evoked potentials were recorded in the right primary somatosensory cortex of the cat following electrical stimulation of the left C5 root of the phrenic nerve. The majority of primary sites were located in the vicinity of the postcruciate dimple, in area 3a near the 3a/3b border, corresponding to the trunk region of the cortical body map. Retrograde fluorescent tracers injected at the sites of primary activation produced labeled cells in the oralis nucleus of the ventroposterior complex [4]. Control injections made in adjacent cortical areas not activated by phrenic stimulation resulted in labeling in the ventroposterior complex which did not overlap that seen with injections of primary activation sites. We conclude that respiratory muscle afferents in the phrenic nerve elicit activity in the trunk region of primary somatosensory cortex via specific thalamocortical projections originating in the oralis portion of the thalamic ventroposterior complex.
Yates
J S
JS
Department of Physiological Sciences, College of Veterinary Medicine, University of Florida, Gainesville 32610.
Davenport
P W
PW
Reep
R L
RL
D000344:Afferent Pathways / Q000502:physiology; D000578:Amidines; D000818:Animals; D001931:Brain Mapping; D002415:Cats; D003911:Dextrans; D004558:Electric Stimulation; D005073:Evoked Potentials, Somatosensory; D005260:Female; D005456:Fluorescent Dyes; D008297:Male; D010791:Phrenic Nerve / Q000502:physiology*; D012235:Rhodamines; D013003:Somatosensory Cortex / Q000502:physiology*; D013266:Stilbamidines; D013788:Thalamus / Q000502:physiology*
C049774:2-hydroxy-4,4'-diamidinostilbene, methanesulfonate salt; D000578:Amidines; D003911:Dextrans; D005456:Fluorescent Dyes; C067661:Fluoro-Ruby; D012235:Rhodamines; D013266:Stilbamidines; C031455:diamidino compound 253-50