title: Macrophage colony stimulating factor inhibits experimental liver metastases from colon cancer.
abstract: This study investigated the inhibitory effect of human macrophage colony stimulating factor (hM-CSF) on experimental liver metastases. Murine colon cancer cell lines C-26 and C-36 were each injected into the spleen of BALB/c mice and the number of subsequent liver metastases was counted. An optimal dose (3,000U/body/day) of hM-CSF to inhibit liver metastases was identified. Additionally, hM-CSF (3,000U/body/day) administration for 7 days before and after the injection of the same cancer cell lines was investigated. The mean number of liver metastases decreased significantly in the hM-CSF group compared with the saline group. These results suggest potential therapeutic benefit for the use of hM-CSF in the adjuvant treatment of liver metastases.
authors.affiliation: First Department of Surgery, Sapporo Medical University, School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Hirata
authors.forename: K
authors.initials: K
authors.lastname: Torimoto
authors.forename: T
authors.initials: T
authors.lastname: Sakawaki
authors.forename: M
authors.initials: M
authors.lastname: Nakamura
authors.forename: N
authors.initials: N
authors.lastname: Sato
authors.forename: K
authors.initials: K
authors.lastname: Kikuchi
mesh_terms: D000818:Animals; D003110:Colonic Neoplasms / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D008114:Liver Neoplasms, Experimental / Q000517:prevention & control* / Q000556:secondary*; D016173:Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D016173:Macrophage Colony-Stimulating Factor