The antitumor activity of the DNA fraction from Mycobacterium bovis BCG (MY-1) for glioblastoma.
The antitumor activity of the DNA fraction extracted from Mycobacterium bovis BCG (MY-1) for glioblastoma was investigated in the experimentally produced brain tumor in rats. The tumor-bearing rats were given intralesional injection of 1 mg of MY-1 twice a week for three weeks, and were sacrificed for comparison with those of control rats. The main macroscopic features of the tumors treated with serial injections of MY-1 were cystic and destructive structures, which were histologically characterized by multiple microcysts containing macrophages. Furthermore, infiltration of leukocytes as well as the perivascular cuffing in the marginal area was observed. These findings suggested that the serial injections of MY-1 into the brain tumor have the therapeutic potential for glioblastoma.
Nakaichi
M
M
Department of Veterinary Surgery, Yamaguchi University, Japan.
Takeuchi
A
A
Shitara
N
N
Takakura
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D001932:Brain Neoplasms / Q000188:drug therapy* / Q000473:pathology; D004269:DNA, Bacterial / Q000627:therapeutic use*; D005909:Glioblastoma / Q000188:drug therapy* / Q000473:pathology; D008297:Male; D009163:Mycobacterium bovis; D051381:Rats; D017208:Rats, Wistar
D000970:Antineoplastic Agents; D004269:DNA, Bacterial