HLA-mismatched cord blood transplantation: immunological studies.
Two cases of HLA partially matched related cord blood transplantation were reported. The first patient remains healthy more than 4 years after graft. The second patient died from acute GVHD. In the first case, the immune reconstitution was studied over a 2 year period after graft: the alloreactive cytotoxic T-cell precursor (CTLp) frequencies were comparable between the donor and the recipient. Indirect evidence suggested that the resolution of GVHD was not due to a specific deletion of CTLp against the HLA antigens unshared between donor and recipient.
Vilmer
E
E
Service d'Hémato-Immunologie, INSERM, Hôpital Robert Debre, Paris, France.
Quelvennec
E
E
Plouvier
E
E
Denamur
E
E
Rohrlich
P
P
Elion
J
J
Sterkers
G
G
D002648:Child; D002675:Child, Preschool; D017809:Fatal Outcome; D005260:Female; D005312:Fetal Blood / Q000166:cytology* / Q000276:immunology; D006085:Graft Survival; D006086:Graft vs Host Disease / Q000209:etiology*; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006680:HLA Antigens / Q000276:immunology*; D006239:Haplotypes / Q000276:immunology; D018380:Hematopoietic Stem Cell Transplantation / Q000009:adverse effects; D006648:Histocompatibility; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D009679:Nuclear Family; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D016879:Salvage Therapy; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology / Q000637:transplantation
D006680:HLA Antigens; D016179:Granulocyte Colony-Stimulating Factor