Neural crest development. Do developing enteric neurons need endothelins?
Recent experiments have led to the unexpected finding that endothelin-3 and the endothelin B receptor are absolutely necessary for the development of the enteric nervous system in the colon, but it is not yet clear why.
Gershon
M D
MD
Department of Anatomy and Cell Biology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA.
D000818:Animals; D003106:Colon / Q000196:embryology / Q000294:innervation; D003370:Coturnix / Q000196:embryology; D004195:Disease Models, Animal; D016232:Endothelins / Q000235:genetics / Q000502:physiology*; D017615:Enteric Nervous System / Q000196:embryology* / Q000502:physiology; D005804:Genes, Lethal; D006627:Hirschsprung Disease / Q000196:embryology; D051379:Mice; D018345:Mice, Knockout; D008817:Mice, Mutant Strains; D009432:Neural Crest / Q000502:physiology* / Q000637:transplantation; D017466:Receptors, Endothelin / Q000502:physiology; D014183:Transplantation, Heterologous
D016232:Endothelins; D017466:Receptors, Endothelin