title: Hyperbaric oxygen treatment of osteoradionecrosis of the mandible. Experience in 29 patients.
abstract: In recent years hyperbaric oxygen has gained an important role in the treatment of osteoradionecrosis of the mandible. In the treatment of 29 patients with osteoradionecrosis of the mandible, a combination of surgical debridement, antibiotics, and hyperbaric oxygen was used in 27 cases. In 20 of the 29 patients the osteoradionecrosis was considered to be resolved after treatment. In 31% of the patients, the continuity of the mandible was lost. It was concluded that combined treatment of surgical debridement, antibiotics, and hyperbaric oxygen gives acceptable results and may, when used in an early phase of the disease, limit the number of patients who lose continuity of the mandible.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Academic Hospital Leiden, The Netherlands.
authors.forename: J P
authors.initials: JP
authors.lastname: van Merkesteyn
authors.forename: D J
authors.initials: DJ
authors.lastname: Bakker
authors.forename: A M
authors.initials: AM
authors.lastname: Borgmeijer-Hoelen
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000532:radiotherapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D006931:Hyperbaric Oxygenation; D008297:Male; D008336:Mandibular Diseases / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000532:radiotherapy; D010025:Osteoradionecrosis / Q000188:drug therapy / Q000601:surgery / Q000628:therapy*; D012189:Retrospective Studies; D012468:Salivary Gland Neoplasms / Q000532:radiotherapy; D013964:Thyroid Neoplasms / Q000532:radiotherapy; D016896:Treatment Outcome