title: cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila.
abstract: In Drosophila, the dorsal-ventral polarity of the egg chamber depends on the localization of the oocyte nucleus and the gurken RNA to the dorsal-anterior corner of the oocyte. Gurken protein presumably acts as a ligand for the Drosophila EGF receptor (torpedo/DER) expressed in the somatic follicle cells surrounding the oocyte. cornichon is a gene required in the germline for dorsal-ventral signaling. cornichon, gurken, and torpedo also function in an earlier signaling event that establishes posterior follicle cell fates and specifies the anterior-posterior polarity of the egg chamber. Mutations in all three genes prevent the formation of a correctly polarized microtubule cytoskeleton required for proper localization of the anterior and posterior determinants bicoid and oskar and for the asymmetric positioning of the oocyte nucleus.
authors.affiliation: Department of Molecular Biology, Howard Hughes Medical Institute, Princeton University, New Jersey 08544, USA.
authors.forename: S
authors.initials: S
authors.lastname: Roth
authors.forename: F S
authors.initials: FS
authors.lastname: Neuman-Silberberg
authors.forename: G
authors.initials: G
authors.lastname: Barcelo
authors.forename: T
authors.initials: T
authors.lastname: Schüpbach
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016764:Cell Polarity / Q000235:genetics; D004247:DNA / Q000235:genetics; D004330:Drosophila / Q000196:embryology* / Q000235:genetics / Q000502:physiology; D029721:Drosophila Proteins; D066246:ErbB Receptors / Q000235:genetics / Q000502:physiology; D005260:Female; D017344:Genes, Insect; D007301:Insect Hormones / Q000235:genetics; D008969:Molecular Sequence Data; D009154:Mutation; D009865:Oocytes / Q000378:metabolism / Q000648:ultrastructure; D010053:Ovary / Q000166:cytology / Q000196:embryology; D012313:RNA / Q000235:genetics / Q000378:metabolism; D015398:Signal Transduction; D016211:Transforming Growth Factor alpha; D015291:Transforming Growth Factors / Q000235:genetics
chemical_list: D029721:Drosophila Proteins; D007301:Insect Hormones; D016211:Transforming Growth Factor alpha; C083730:grk protein, Drosophila; D012313:RNA; D015291:Transforming Growth Factors; D004247:DNA; D066246:ErbB Receptors