title: Fungal metabolites. XVIII. New membrane-modifying peptides, trichorozins I-IV, from the fungus Trichoderma harzianum.
abstract: New membrane-modifying peptides, trichorozins I-IV, have been isolated from conidia of the fungus Trichoderma harzianum. Their amino acid sequences were clearly determined by spectrometric methods and, furthermore, they were synthesized by the solution-phase method. Trichorozins are a family of the class of peptaibols and are composed of 11 residues including an amino alcohol. Trichorozins exhibited voltage-dependent ion channel-like activity in lipid bilayers.
authors.affiliation: Faculty of Pharmaceutical Sciences, Kyoto University, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Iida
authors.forename: M
authors.initials: M
authors.lastname: Sanekata
authors.forename: S
authors.initials: S
authors.lastname: Wada
authors.forename: T
authors.initials: T
authors.lastname: Fujita
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Enoki
authors.forename: G
authors.initials: G
authors.lastname: Fuse
authors.forename: M
authors.initials: M
authors.lastname: Kanai
authors.forename: K
authors.initials: K
authors.lastname: Asami
mesh_terms: D000595:Amino Acid Sequence; D005656:Fungal Proteins / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology*; D007473:Ion Channels / Q000187:drug effects; D008051:Lipid Bilayers; D008565:Membrane Proteins / Q000187:drug effects; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000096:biosynthesis / Q000737:chemistry* / Q000494:pharmacology*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014242:Trichoderma / Q000737:chemistry* / Q000378:metabolism*
chemical_list: D005656:Fungal Proteins; D007473:Ion Channels; D008051:Lipid Bilayers; D008565:Membrane Proteins; D009842:Oligopeptides