Linkage analyses of the MODY3 locus on chromosome 12q with late-onset NIDDM.
Non-insulin-dependent diabetes mellitus (NIDDM) is a clinically and genetically heterogeneous disorder. Maturity-onset diabetes of the young (MODY), an autosomal dominant form of NIDDM, has been used as a model for genetic studies of NIDDM. We recently reported linkage between markers on chromosome 12q and diabetes in 25% of our French MODY families. To evaluate if this gene is also implicated in late-onset NIDDM, we performed linkage studies between two markers of the MODY region and diabetes in 172 families with late-onset NIDDM. Both parametric and nonparametric methods were used in a total of 600 affected sib-pairs. Linkage was rejected in this population by all methods, implying that the MODY gene on chromosome 12q is not a major gene for late-onset NIDDM in this population. However, we cannot exclude a modifying role in a polygenic disorder or an important role in some families.
Lesage
S
S
Centre National de la Recherche Scientifique EP10, CEPH, Paris, France.
Hani
E H
EH
Philippi
A
A
Vaxillaire
M
M
Hager
J
J
Passa
P
P
Demenais
F
F
Froguel
P
P
Vionnet
N
N
D000328:Adult; D000367:Age Factors; D017668:Age of Onset; D001483:Base Sequence; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D017931:DNA Primers; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics* / Q000503:physiopathology; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010290:Parents; D016133:Polymerase Chain Reaction; D012727:Sex Characteristics
D017931:DNA Primers