Effects of ipsilateral denervation and contralateral ureteral obstruction on tubuloglomerular feedback.
The effects of acute ipsilateral denervation (AID) and contralateral ureteral obstruction on tubuloglomerular feedback (TGF) was studied by micropuncture in rats. Denervation alone was associated with an increase in the TGF turning point, the tubular flow rate required for a half-maximal TGF response, but other TGF characteristics were not affected. Contralateral ureteral obstruction alone was also associated with an increased turning point, but contralateral obstruction had no effect on turning point, when AID was done prior to the obstruction. We conclude that renal nerves have a tonic modulating effect on TGF in anesthetized rats, and that renorenal reflexes are involved in the TGF resetting associated with acute contralateral ureteral obstruction.
Wilke
W L
WL
Department of Physiology, Colorado State University, Fort Collins 80523, USA.
Persson
A E
AE
D000818:Animals; D003714:Denervation; D005246:Feedback / Q000502:physiology; D005919:Glomerular Filtration Rate; D007668:Kidney / Q000293:injuries* / Q000502:physiology; D007678:Kidney Glomerulus / Q000502:physiology*; D007684:Kidney Tubules / Q000502:physiology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D014524:Urethral Obstruction / Q000503:physiopathology*