title: Dr fimbriae coding region associated hemolytic activity of Escherichia coli.
abstract: We investigated the hemolytic activity of Escherichia coli strain EC901 carrying plasmid pBJN406 containing genes draA-E involved in expression of the mannose-resistant Dr hemagglutinin, and in its isogenic insertion mutants devised with Tn5, Tn3, and TnphoA. While E. coli BN406 displayed rapid hemolytic activity against equine erythrocytes, insertion mutations in draD and draE, but not in draA, draB, and draC, abolished all hemolytic activity. These data suggest a role for draD and draE in the expression of hemolysis.
authors.affiliation: University of Texas Medical Branch at Galveston, Department of Obstetics and Gynecology 77555-1062, USA.
authors.forename: P
authors.initials: P
authors.lastname: Goluszko
authors.forename: S
authors.initials: S
authors.lastname: Nowicki
authors.forename: A K
authors.initials: AK
authors.lastname: Kaul
authors.forename: T
authors.initials: T
authors.lastname: Pham
authors.forename: B J
authors.initials: BJ
authors.lastname: Nowicki
mesh_terms: D018830:Adhesins, Escherichia coli / Q000235:genetics*; D000818:Animals; D001426:Bacterial Proteins / Q000096:biosynthesis; D004251:DNA Transposable Elements / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics / Q000502:physiology*; D010861:Fimbriae, Bacterial / Q000235:genetics*; D005798:Genes, Bacterial / Q000235:genetics; D006388:Hemagglutinins / Q000235:genetics*; D006461:Hemolysis / Q000235:genetics*; D006736:Horses; D009154:Mutation / Q000502:physiology; D010957:Plasmids / Q000235:genetics
chemical_list: D018830:Adhesins, Escherichia coli; D001426:Bacterial Proteins; D004251:DNA Transposable Elements; D006388:Hemagglutinins