Castration increases [125I]MK801 binding in the hippocampus of male rats.
This study examines the effect of castration and androgen replacement on [125I]MK801 binding in the hippocampus. In castrated male rats, [125I]MK801 binding was significantly increased in both the stratum oriens and radiatum and the pyramidal cell layer of CA1. In contrast, no increase in [125I]MK801 binding was observed in the stratum oriens and radiatum of CA1 of castrated rats that were treated with dihydrotestosterone. No change in [125I]MK801 binding was observed in the CA3 region or dentate gyrus after castration. The observed increase in [125I]MK801 binding in pyramidal cell neurons within CA1 suggests that androgens may potentially affect hippocampal function by modulating pyramidal cell NMDA receptors.
Kus
L
L
Department of Veterinary PathoBiology, University of Minnesota, St. Paul 55108, USA.
Handa
R J
RJ
Hautman
J M
JM
Beitz
A J
AJ
D000728:Androgens / Q000172:deficiency / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D016291:Dizocilpine Maleate / Q000378:metabolism* / Q000494:pharmacology; D006624:Hippocampus / Q000378:metabolism*; D007457:Iodine Radioisotopes; D008297:Male; D009919:Orchiectomy; D051381:Rats; D011916:Rats, Inbred F344; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
D000728:Androgens; D007457:Iodine Radioisotopes; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate