Angiogenic growth factors in neural embryogenesis and neoplasia.
"Blood vessels have the power to increase within themselves which is according to the necessity whether natural or diseased. As a further proof that this is a general principle, we find that all growing parts are much more vascular than those that are come to their full growth; because growth is an operation beyond the simple support of the part. This is the reason why young animals are more vascular than those that are full grown. This is not peculiar to the natural operation of growth, but applies also to disease and restoration."
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Department of Pathology, Kaplan Comprehensive Cancer Center, New York University Medical Center, New York.
D000818:Animals; D001932:Brain Neoplasms / Q000098:blood supply* / Q000473:pathology; D016228:Endothelial Growth Factors / Q000737:chemistry / Q000502:physiology; D005346:Fibroblast Growth Factors / Q000737:chemistry / Q000502:physiology; D006133:Growth Substances / Q000737:chemistry / Q000502:physiology*; D006801:Humans; D008222:Lymphokines / Q000737:chemistry / Q000502:physiology; D051379:Mice; D009389:Neovascularization, Pathologic / Q000473:pathology*; D009420:Nervous System / Q000196:embryology*; D010982:Platelet-Derived Growth Factor / Q000737:chemistry / Q000502:physiology; D051381:Rats; D016212:Transforming Growth Factor beta / Q000737:chemistry / Q000502:physiology; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors
D016228:Endothelial Growth Factors; D006133:Growth Substances; D008222:Lymphokines; D010982:Platelet-Derived Growth Factor; D016212:Transforming Growth Factor beta; D042461:Vascular Endothelial Growth Factor A; D042442:Vascular Endothelial Growth Factors; D005346:Fibroblast Growth Factors