[Tumors--disorders of cell adhesion].
Cell adhesion molecules are of pivotal importance during organogenesis and fulfil important functions in maintaining normal organ architecture in the adult. Furthermore, they are involved in diverse and specialized functions such as migration and activation of leukocytes in immunosurveillance and inflammation, and homophilic as well as heterophilic interactions of cells with others and the extracellular matrix. In tumors, various cell adhesion molecules play a role in the complex process of tumor dissemination including metastatic spread. In addition, immunohistochemical detection of certain cell adhesion molecules in tumors has been shown to be of value in predicting the clinical course of the tumor disease. This short review focuses on the polysialic acid of the neural cell adhesion molecule NCAM, integrins and CD44.
Roth
J
J
Departement Pathologie, Universität Zürich, Schweiz.
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D002448:Cell Adhesion; D015815:Cell Adhesion Molecules / Q000032:analysis / Q000502:physiology*; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology; D006801:Humans; D018960:Hyaluronan Receptors; D016023:Integrins / Q000032:analysis / Q000502:physiology*; D009369:Neoplasms / Q000276:immunology / Q000473:pathology / Q000503:physiopathology*; D011956:Receptors, Cell Surface / Q000502:physiology; D016201:Receptors, Lymphocyte Homing / Q000502:physiology
D002352:Carrier Proteins; D015815:Cell Adhesion Molecules; D015816:Cell Adhesion Molecules, Neuronal; D018960:Hyaluronan Receptors; D016023:Integrins; D011956:Receptors, Cell Surface; D016201:Receptors, Lymphocyte Homing