Serotonergic measures in cyclosporine A treated rats.
Whole blood and plasma serotonin (5-HT), its major metabolite--5-hydroxyindoleacetic acid (5-HIAA), renal cortical blood flow, serum creatinine and whole blood cyclosporine A (CyA) levels were investigated in rats administered with CyA at a dose of 5 mg/kg b.w. or 10 mg/kg b.w. for 14 consecutive days. Serum creatinine remained unaltered during CyA treatment and no apparent changes in excised kidneys were found. Dose-dependent increases in whole blood and plasma 5-HT as well as whole blood 5-HIAA levels were observed. Renal cortical blood flow declined significantly and correlated inversely with whole blood 5-HT and 5-HIAA as well as with plasma 5-HT. Whole blood 5-HT was positively related to whole blood CyA levels. Taking all these data into account and considering the fact that 5-HT is a potent vasoconstrictor, a possible role of this amine in the pathogenesis of renal ischemia during CyA administration is suggested.
Ueda
D
D
Department of Urology, Hamamatsu University School of Medicine, Japan.
Suzuki
K
K
Malyszko
J
J
Pietraszek
M H
MH
Takada
Y
Y
Takada
A
A
Kawabe
K
K
D000818:Animals; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000494:pharmacology* / Q000633:toxicity; D006897:Hydroxyindoleacetic Acid / Q000097:blood; D007674:Kidney Diseases / Q000139:chemically induced* / Q000503:physiopathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012079:Renal Circulation / Q000187:drug effects; D012701:Serotonin / Q000097:blood* / Q000502:physiology; D014661:Vasoconstriction
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D016572:Cyclosporine; D003404:Creatinine