[Alpha tumor necrosis factor in central nervous system disease associated with HIV infection].
The aim of the present study is to evaluate the relationship between the alpha tumor necrosis factor (TNF-alpha), interleukin 1 beta (IL-1 beta) and the neurological disease associated to the HIV-1 infection and different neurological manifestations (15 infections of the CNS and 11 AIDS-dementia complexes) and 14 from a control group. The mean value of TNF-alpha in CSF of patients with HIV-1 infection and AIDS-dementia complex was 19.8 +/- 30.6 pg/ml, superior to that of the control group (p < 0.05). The group of patients with HIV-1 and opportunistic CNS infection has a TNF-alpha value of 28.5 +/- 37.8 pg/ml, that is superior to that of the patients with the AIDS-dementia complex (TNF-alpha = 7.9 +/- 9.4 pg ml; p < 0.05). Within the group of patients with a CNS infection, the value of TNF-alpha was greater in those in the acute phase (44.2 +/- 42.4 pg/ml) than in those in the chronic phase (6.8 +/- 7.6 pg/ml; p < 0.05). The TNF-alpha in the CSF is a good marker of infection of the CNS in the HIV-1 infection.
Calvo Manuel
E
E
Servicio de Medicina Interna I, Hospital Universitario San Carlos, Facultad de Medicina, Universidad Complutense, Madrid.
Arranz Garcia
F
F
Sánchez-Portocarrero
J
J
Roca Arbones
V
V
Puente
M
M
Elias Arcalis
A
A
Pérez-Cecilia
E
E
Nieto Sánchez
A
A
Espinos Pérez
D
D
D015526:AIDS Dementia Complex / Q000134:cerebrospinal fluid* / Q000175:diagnosis; D000163:Acquired Immunodeficiency Syndrome / Q000134:cerebrospinal fluid / Q000150:complications / Q000175:diagnosis*; D015415:Biomarkers; D002493:Central Nervous System Diseases / Q000134:cerebrospinal fluid / Q000175:diagnosis* / Q000209:etiology; D003627:Data Interpretation, Statistical; D004797:Enzyme-Linked Immunosorbent Assay; D015497:HIV-1; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000134:cerebrospinal fluid*
D015415:Biomarkers; D007375:Interleukin-1; D014409:Tumor Necrosis Factor-alpha