Self-treatment of female external genital warts with 0.5% podophyllotoxin cream (Condyline) vs weekly applications of 20% podophyllin solution.
Sixty women with genital warts were randomly allocated to treatment with either weekly application of 20% podophyllin solution or self-treatment with 0.5% podophyllotoxin cream twice daily for three days in weekly intervals. After a maximum of 4 treatment cycles a final assessment was carried out after 3 months. Primary clearance after termination of treatment was 82% for podophyllotoxin and 59% for podophyllin solution. After excluding relapses at the 3-month follow-up, final clearance for podophyllotoxin (71%) was significantly better (P < 0.05) than that for podophyllin solution (48%). The total frequency of warts eradicated was 94% with podophyllotoxin and 74% with podophyllin solution (P < 0.001). Local adverse effects were generally mild or moderate. Podophyllotoxin cream provides a mode of easy application for women with external genital warts and had in this study a significantly better effect than podophyllin solution.
Hellberg
D
D
Department of Obstetrics and Gynecology, Falun Hospital, Sweden.
Svarrer
T
T
Nilsson
S
S
Valentin
J
J
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D003218:Condylomata Acuminata / Q000188:drug therapy*; D005260:Female; D005500:Follow-Up Studies; D005831:Genital Diseases, Female / Q000188:drug therapy*; D006801:Humans; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008875:Middle Aged; D009824:Ointments; D011033:Podophyllin / Q000627:therapeutic use*; D011034:Podophyllotoxin / Q000627:therapeutic use*; D012008:Recurrence; D012996:Solutions
D007641:Keratolytic Agents; D009824:Ointments; D012996:Solutions; D011033:Podophyllin; D011034:Podophyllotoxin