Incidence of different forms of thyroid dysfunction and its degrees in an iodine sufficient area.
OBJECTIVE
The aim of the study was to determine the incidence of thyroid dysfunction in an iodine sufficient area (Vigo city, Galicia, North-West of Spain).


METHODS
Case-finding study during a 3-year (1990-1992) period.


METHODS
Subjects from a random sample of the population with abnormal results on FT4, sensitive-TSH or antithyroid autoantibodies.


METHODS
Thyroid size by ultrasound study. FT4 by RIA; TSA Ab by radio receptor assays; TSH, Tg Ab and TMS Ab by IRMA.


RESULTS
Overall incidence of thyroid dysfunction was 97.96 per 100,000 per year (CI 95% 78.86-117.06); female 162.45, male 17.44. Incidence rate of hyperthyroidism was 52.37 per 100,000 per year (CI 95% 38.41-66.36); 24.24 for Graves' disease, 11.63 for nodular hyperthyroidism, 13.57 for iatrogenic hyperthyroidism and 2.90 for others causes. Incidence rate of hypothyroidism was 45.58 per 100,000 per year (CI 95% 32.55-58.620 27.15 for hypothyroid autoimmune thyroiditis, 8.72 for postoperative hypothyroidism, 4.89 for miscellaneous hypothyroidism, 1.93 for amiodarone induced hypothyroidism and 2.90 for secondary hypothyroidism.


CONCLUSIONS
This investigation provides extensive data on incidence of clinical and subclinical thyroid dysfunction and its different forms in an iodine sufficient area.
Galofré
J C
JC
Endocrine Division, General Hospital of Vigo, Spain.
García-Mayor
R V
RV
Fluiters
E
E
Fernàndez-Calvet
L
L
Rego
A
A
Pàramo
C
C
Andrade
M A
MA
D000328:Adult; D000368:Aged; D001327:Autoimmune Diseases / Q000453:epidemiology; D005260:Female; D006111:Graves Disease / Q000453:epidemiology; D006801:Humans; D006980:Hyperthyroidism / Q000453:epidemiology; D007037:Hypothyroidism / Q000453:epidemiology / Q000209:etiology; D015994:Incidence; D007455:Iodine; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D012727:Sex Characteristics; D013959:Thyroid Diseases / Q000453:epidemiology*; D013966:Thyroiditis / Q000453:epidemiology
D007455:Iodine