title: Phase II study of fludarabine phosphate for gastric adenocarcinoma. An Illinois Cancer Center trial.
abstract: In an Illinois Cancer Center phase II trial, fludarabine phosphate was administered to a total of 14 patients (9 men, 5 women) with advanced, measurable, gastric adenocarcinoma. Fludarabine phosphate was given as a rapid intravenous (IV) bolus at a starting dose of 20 mg/m2/d for the first 5 days of a 28-day cycle. For subsequent cycles, the dose was escalated in increments of 2 mg/m2/d, provided that no toxicities greater than grade 1 were noted. In cases of grade 3 toxicity, dose reductions of 2 mg/m2/d were required, and patients who experienced grade 4 toxicities were removed from study. Receiving one complete 5-day course of fludarabine phosphate and surviving for 4 weeks on study were required for a patient to be evaluable for response. None of the patients responded to treatment. Although fludarabine phosphate was ineffective against gastric adenocarcinoma in this study, toxicity was acceptable at the 20 mg/m2/d times 5 every 28 days dose and schedule.
authors.affiliation: Kilton Hematology/Oncology Practice, Island Lake, IL.
authors.forename: L J
authors.initials: LJ
authors.lastname: Kilton
authors.forename: J B
authors.initials: JB
authors.lastname: Ashenhurst
authors.forename: J L
authors.initials: JL
authors.lastname: Wade
authors.forename: R L
authors.initials: RL
authors.lastname: Schilsky
authors.forename: G
authors.initials: G
authors.lastname: Shiomoto
authors.forename: R R
authors.initials: RR
authors.lastname: Blough
authors.forename: S L
authors.initials: SL
authors.lastname: French
authors.forename: A B
authors.initials: AB
authors.lastname: Benson
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000188:drug therapy*; D001084:Vidarabine Phosphate / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use
chemical_list: D000964:Antimetabolites, Antineoplastic; D001084:Vidarabine Phosphate; C042382:fludarabine phosphate