title: The humoral response to an allograft.
abstract: Antibodies are known to damage grafted tissues by a variety of means, so it is important to know how the humoral response is initiated. In this paper we summarise the cellular events in B cell activation, the mechanisms of antibody-mediated rejection and the evidence that antibody apparently does not contribute to early corneal graft rejection. The role of antibodies in chronic graft loss is discussed.
authors.affiliation: School of Biological Sciences, University of Manchester Medical School, UK.
authors.forename: I V
authors.initials: IV
authors.lastname: Hutchinson
authors.forename: Y
authors.initials: Y
authors.lastname: Alam
authors.forename: W R
authors.initials: WR
authors.lastname: Ayliffe
mesh_terms: D000818:Animals; D000917:Antibody Formation; D000938:Antigen-Presenting Cells / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology*; D016039:Corneal Transplantation / Q000276:immunology*; D016207:Cytokines / Q000276:immunology; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D008213:Lymphocyte Activation; D008285:Major Histocompatibility Complex; D051381:Rats; D011917:Rats, Inbred Lew; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology
chemical_list: D016207:Cytokines