title: In-111 DTPA Ommayagrams in leptomeningeal carcinomatosis.
abstract: Radionuclide Ommayagrams in 25 patients with leptomeningeal carcinomatosis were performed after injection of 0.5 mCl of In-111 DTPA into Ommaya shunt reservoirs to evaluate cerebrospinal fluid-shunt communication, detect the blockage of the cerebrospinal fluid pathway, evaluate the cerebrospinal fluid flow pattern, and predict the distribution of the chemotherapeutics. All results were correlated with MRI evaluations of the brain and spine, as well as clinical findings. Radionuclide Ommayagrams were found to be 73% sensitive and 100% specific in the evaluation of cerebrospinal fluid space disease. MRI of the spine and head was found to be 100% sensitive, but 86% specific for obstructive cerebrospinal fluid space disease.
authors.affiliation: Department of Nuclear Medicine, University of Texas M.D. Anderson Cancer Center, Houston 77030, USA.
authors.forename: M
authors.initials: M
authors.lastname: Korkmaz
authors.forename: E E
authors.initials: EE
authors.lastname: Kim
authors.forename: F C
authors.initials: FC
authors.lastname: Wong
authors.forename: D A
authors.initials: DA
authors.lastname: Podoloff
authors.forename: T P
authors.initials: TP
authors.lastname: Haynie
authors.forename: A
authors.initials: A
authors.lastname: Yung
mesh_terms: D000293:Adolescent; D000328:Adult; D002277:Carcinoma / Q000000981:diagnostic imaging*; D002555:Cerebrospinal Fluid / Q000000981:diagnostic imaging*; D002557:Cerebrospinal Fluid Shunts; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007205:Indium Radioisotopes; D007223:Infant; D008297:Male; D008577:Meningeal Neoplasms / Q000000981:diagnostic imaging*; D008875:Middle Aged; D004369:Pentetic Acid; D011877:Radionuclide Imaging
chemical_list: D007205:Indium Radioisotopes; D004369:Pentetic Acid