[Activation of complement during hemodialysis].
In hemodialysis using 3 types of dialysis membrane materials [regenerated cellulose (RC), cellulose triacetate (CTA), and polysulfone (PS)], activation of the complement, reduction of white blood cells, and variation of vitronectin (VN) were observed. RC membrane caused a significant reduction of white blood cells and elevations of Bb and soluble membrane attack complex (S-MAC), indicating a strong activation of the alternative complement pathway. Especially, the increase of S-MAC persisted for a long time during hemodialysis. Because reduction of VN was transient, it was assumed that the S-MAC escaping removal by VN receptors might have persisted in the circulation. These findings suggested that S-MAC would become useful as an index for evaluating biocompatibility of various artificial organs including dialysis membranes.
Nagake
Y
Y
Third Department of Internal Medicine, Okayama University Medical School.
Amano
T
T
Wada
J
J
Sugimoto
H
H
Kawabata
K
K
Shikata
K
K
Makino
H
H
Ota
Z
Z
D000368:Aged; D001672:Biocompatible Materials; D002482:Cellulose / Q000031:analogs & derivatives; D003167:Complement Activation; D015938:Complement Membrane Attack Complex; D003170:Complement Pathway, Alternative; D003165:Complement System Proteins / Q000378:metabolism; D005260:Female; D005921:Glomerulonephritis / Q000276:immunology* / Q000628:therapy; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D007970:Leukopenia / Q000209:etiology; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D011108:Polymers; D006435:Renal Dialysis / Q000295:instrumentation*; D013450:Sulfones; D019096:Vitronectin / Q000378:metabolism
D001672:Biocompatible Materials; D015938:Complement Membrane Attack Complex; D006023:Glycoproteins; D008567:Membranes, Artificial; D011108:Polymers; C047610:SC5b-9 protein complex; D013450:Sulfones; D019096:Vitronectin; C017662:polysulfone P 1700; D002482:Cellulose; D003165:Complement System Proteins; C024671:cellulose triacetate