Apoptosis, Fas and systemic autoimmunity: the MRL-lpr/lpr model.
Proteins encoded by the fas and fas ligand (fasL) genes are involved in apoptotic cell death in lymphocytes. In this article we review the recent elucidation of the role of the Fas-FasL interactions in the maintenance of tolerance to self antigens and in the homeostatic regulation of lymphocyte clonal expansion, and discuss the mechanisms of autoimmunity in Fas- and FasL-deficient mutant mouse strains.
Singer
G G
GG
Department of Pathology, Brigham and Women's Hospital, Boston, MA 02115.
Carrera
A C
AC
Marshak-Rothstein
A
A
Martínez
C
C
Abbas
A K
AK
D000818:Animals; D000954:Antigens, Surface / Q000276:immunology*; D017209:Apoptosis; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D004195:Disease Models, Animal; D053222:Fas Ligand Protein; D006801:Humans; D007108:Immune Tolerance; D008232:Lymphoproliferative Disorders / Q000235:genetics / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology*; D051379:Mice; D008817:Mice, Mutant Strains; D019014:fas Receptor
D000954:Antigens, Surface; D001324:Autoantigens; C505661:FASLG protein, human; D053222:Fas Ligand Protein; C505658:Fasl protein, mouse; D008562:Membrane Glycoproteins; D019014:fas Receptor