[A complex evaluation of the lytic potential of cellular cytotoxicity displayed by natural killers and K cells].
The method of testing the lytic potential of cell cytotoxicity, shown by whole-blood natural killer (NK) cells and K-cells, including the determination of the responsiveness of killers to interferon, is proposed. The method makes it possible to carry out mass survey of the population and to work with contaminated material. In this study the influence of different gene engineering preparations of interferon on the activity NK cells of humans and hamadryas monkeys is determined. The individual reaction of killers to their stimulation with interferon was confirmed. The study revealed that in volunteers immunized with yellow fever vaccine a decrease in the sensitivity of NK cells was observed.
Solokhin
E V
EV
Pchelintseva
S Iu
SIu
Afanas'ev
S S
SS
Vorob'ev
A A
AA
D000328:Adult; D000818:Animals; D003601:Cytotoxicity Tests, Immunologic / Q000379:methods; D003602:Cytotoxicity, Immunologic / Q000187:drug effects / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007372:Interferons / Q000494:pharmacology; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology*; D004915:Leukemia, Erythroblastic, Acute / Q000276:immunology; D008297:Male; D010215:Papio; D011994:Recombinant Proteins / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D014765:Viral Vaccines / Q000276:immunology; D015005:Yellow fever virus / Q000276:immunology
D011994:Recombinant Proteins; D014765:Viral Vaccines; D007372:Interferons