Characterization of the recognition site and diagnostic potential of an enterovirus group-reactive monoclonal antibody.
The epitope for a monoclonal antibody reactive against different enteroviruses was characterized. The epitope could be located to residues 40 to 48 of VP1, and the most-essential residues for monoclonal antibody binding coincided with those conserved among the majority of known enteroviruses, indicating a high diagnostic potential.
Samuelson
A
A
Department of Immunology, Microbiology, Pathology and Infectious Diseases, Karolinska Institutet, Huddinge University Hospital, Sweden.
Forsgren
M
M
Sällberg
M
M
D000595:Amino Acid Sequence; D000911:Antibodies, Monoclonal / Q000276:immunology* / Q000378:metabolism; D001665:Binding Sites / Q000276:immunology; D004770:Enterovirus / Q000276:immunology* / Q000302:isolation & purification; D004769:Enterovirus Infections / Q000175:diagnosis*; D000939:Epitopes / Q000276:immunology; D006801:Humans; D008969:Molecular Sequence Data; D010455:Peptides / Q000276:immunology; D014764:Viral Proteins / Q000276:immunology
D000911:Antibodies, Monoclonal; D000939:Epitopes; D010455:Peptides; D014764:Viral Proteins