The majority of Fc gamma RIII-positive gamma delta T cells do not express HLA-DR in patients with primary Sjögren's syndrome.
The percentages of circulating gamma delta T cells and the proportions of these expressing Fc gamma RIII (CD16) or HLA-DR in patients with primary Sjögren's syndrome (pSS) and controls were determined using monoclonal antibodies and flow cytometry. There was no significant difference in the percentages of gamma delta T cells in the pSS patients compared with controls. There was, however, a significant increase in the proportions of both CD16+ and HLA-DR+ gamma delta T cells in pSS patients. A 3-colour immunofluorescence technique demonstrated that these two markers were mutually exclusive and therefore may identify either subpopulations of gamma delta T cells or different stages of the activation process.
Lamour
A
A
Laboratory of Immunology, Brest University Medical School, France.
Smith
M D
MD
Lydyard
P M
PM
Youinou
P Y
PY
D005260:Female; D006684:HLA-DR Antigens / Q000378:metabolism*; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*; D017452:Receptors, IgG / Q000378:metabolism*; D012859:Sjogren's Syndrome / Q000276:immunology*; D016176:T-Lymphocyte Subsets / Q000378:metabolism*
D006684:HLA-DR Antigens; D016692:Receptors, Antigen, T-Cell, gamma-delta; D017452:Receptors, IgG