Comparative efficacy of nonsteroidal anti-inflammatory drugs and anti-thromboxane agents in a rabbit adhesion-prevention model.
A variety of nonsteroidal anti-inflammatory drugs (NSAIDs) has been found to inhibit postsurgical peritoneal adhesion formation in a number of animal models. A rabbit uterine horn adhesion model was used to directly compare several commonly used NSAIDs of different chemical classes in a single animal study to evaluate their ability to prevent adhesion formation. The effect of thromboxane inhibitors on adhesion prevention was also evaluated. Each of the NSAIDs tested (tolmetin, ibuprofen, aspirin, and indomethacin) showed significant and comparable efficacy. In this same study, imidazole, a thromboxane synthetase inhibitor, also showed significant efficacy. In a second study, ridogrel, an inhibitor of thromboxane synthetase as well as a thromboxane A2 receptor blocker, also showed significant efficacy in reducing peritoneal adhesion severity. These results further support the view that NSAIDs act to prevent adhesions through a common mechanism. In addition, thromboxane A2 inhibitors were also shown to be efficacious in adhesion prevention, suggesting that platelets may play a substantial role in adhesion formation.
LeGrand
E K
EK
Pharmaceutical Research and Development Ethicon, Inc., Somerville, New Jersey, USA.
Rodgers
K E
KE
Girgis
W
W
Campeau
J D
JD
Dizerega
G S
GS
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001241:Aspirin / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D005260:Female; D007052:Ibuprofen / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D010421:Pentanoic Acids / Q000494:pharmacology; D011725:Pyridines / Q000494:pharmacology; D011817:Rabbits; D013928:Thromboxane A2 / Q000037:antagonists & inhibitors* / Q000502:physiology; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control*; D014046:Tolmetin / Q000494:pharmacology; D014591:Uterine Diseases / Q000517:prevention & control; D014599:Uterus / Q000601:surgery
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007093:Imidazoles; D010421:Pentanoic Acids; D011725:Pyridines; D013928:Thromboxane A2; C029899:imidazole; D014046:Tolmetin; D013930:Thromboxane-A Synthase; C060219:ridogrel; D001241:Aspirin; D007052:Ibuprofen; D007213:Indomethacin