Prothymosin alpha mRNA levels vary with c-myc expression during tissue proliferation, viral infection and heat shock.
Expression of prothymosin alpha, an acidic nuclear protein implicated in cellular proliferation, has been reported to be regulated by c-myc in vitro. We have studied the correlation of expression levels between prothymosin alpha and c-myc, using three different in vivo systems, viz. normal ontogenic process of placental development, lytic viral infection and heat shock treatment. The two genes have been found to share a similar expression pattern, although prothymosin alpha mRNA remains always detectable, indicating the existence of yet another mechanism, in addition to c-myc, which regulates its expression in vivo.
Vareli
K
K
Laboratory of Biological Chemistry, University of Ioannina Medical School, Greece.
Frangou-Lazaridis
M
M
Tsolas
O
O
D000256:Adenoviridae; D017500:Adenovirus E1A Proteins / Q000235:genetics; D000818:Animals; D002455:Cell Division; D002460:Cell Line; D005786:Gene Expression Regulation; D006367:HeLa Cells; D006358:Hot Temperature; D006801:Humans; D010920:Placenta / Q000378:metabolism; D011498:Protein Precursors / Q000235:genetics* / Q000378:metabolism; D016271:Proto-Oncogene Proteins c-myc / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism; D013947:Thymosin / Q000031:analogs & derivatives* / Q000235:genetics / Q000378:metabolism
D017500:Adenovirus E1A Proteins; D011498:Protein Precursors; D016271:Proto-Oncogene Proteins c-myc; D012333:RNA, Messenger; C040782:prothymosin alpha; D013947:Thymosin