Poxvirus-based vectors as vaccine candidates.
The safety issues surrounding the use of vaccinia-based vaccine candidates have been significantly addressed with the development of the NYVAC and ALVAC vectors. These vectors can be engineered to express multiple genes from the same pathogen or multiple genes from multiple pathogens. The use of these vectors to develop needed vaccines for human and veterinary medicine remains the focus of studies that are currently in progress.
Pincus
S
S
Virogenetics Corporation, Troy, New York 12180, USA.
Tartaglia
J
J
Paoletti
E
E
D000818:Animals; D005822:Genetic Vectors; D006801:Humans; D011212:Poxviridae / Q000145:classification / Q000235:genetics*; D013045:Species Specificity; D014614:Vaccines, Synthetic / Q000235:genetics
D014614:Vaccines, Synthetic