Increased intracellular glycerophosphoinositol and arachidonic acid are biochemical markers for lindane toxicity.
Lindane stimulates the release of both glycerophosphoinositol and arachidonic acid from phospholipids in rat renal proximal tubular cell cultures. When lindane was added to the culture medium, a correlation between the time-course profiles of glycerophosphoinositol and arachidonate release was found. This suggests a pathway in which phosphatidylinositol is not directly broken down by phospholipase C, but can instead be broken down to glycerophosphoinositol and arachidonic acid by phospholipase A enzymes. Therefore, a mechanism of action of lindane is through its effect on glycerophosphoinositol and arachidonic acid metabolism.
Senar
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S
Departamento de Bioquímica y Biología Molecular, Universidad de Alcalá de Henares, Madrid, Spain.
Puente
J C
JC
López-Aparicio
P
P
Recio
M N
MN
Pérez-Albarsanz
M A
MA
D000818:Animals; D016718:Arachidonic Acid / Q000378:metabolism*; D015415:Biomarkers; D002478:Cells, Cultured; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D010716:Phosphatidylinositols / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism; D051381:Rats; D011963:Receptors, GABA-A / Q000378:metabolism
D015415:Biomarkers; D010716:Phosphatidylinositols; D011963:Receptors, GABA-A; D016718:Arachidonic Acid; D001556:Hexachlorocyclohexane; D010741:Phospholipases A