The role of leukotriene C4 in biphasic release of histamine from mouse mastocytoma cell line (P-815).
1. A biphasic change of compound 48/80-induced histamine release was observed in mastocytoma cell line (P-815). 2. The first and second phase of compound 48/80-induced histamine release were elicited via a different pathway. 3. The second phase of compound 48/80-induced histamine release was provoked with leukotriene (LT) C4. 4. The results suggest that this biphasic release may be one of the important regulatory mechanisms for the production of histamine.
Teshigawara
H
H
Department of Pharmacology, Nihon University School of Dentistry at Matsudo, Chiba, Japan.
Moriya
Y
Y
D000818:Animals; D016227:Benzoquinones / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006636:Histamine Release / Q000187:drug effects*; D007213:Indomethacin / Q000494:pharmacology; D017997:Leukotriene C4 / Q000502:physiology*; D015289:Leukotrienes / Q000494:pharmacology; D012515:Mast-Cell Sarcoma / Q000378:metabolism*; D051379:Mice; D010741:Phospholipases A / Q000502:physiology; D013373:Substance P / Q000494:pharmacology; D014407:Tumor Cells, Cultured; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D016227:Benzoquinones; D015289:Leukotrienes; D017997:Leukotriene C4; D013373:Substance P; D003189:p-Methoxy-N-methylphenethylamine; C036837:2,3,5-trimethyl-6-(12-hydroxy-5,10-dodecadiynyl)-1,4-benzoquinone; D010741:Phospholipases A; D007213:Indomethacin