title: Uhthoff and his symptom.
abstract: At the turn of the last century, Wilhelm Uhthoff was a renowned clinical neuro-ophthalmologist, and probably the first clinician whose entire career was devoted to this discipline. His achievements are among those that mark the commencement of contemporary neuro-ophthalmology. Uhthoff's symptom of visual loss with exercise is most frequently associated with optic neuritis. The symptom carries a major risk for recurrence of optic neuritis and development of multiple sclerosis. This study and its companion in the publication show that, independently, a metabolic byproduct of exercise or increases in body temperature cause a reversible conduction block in demyelinated optic nerves and result in temporary loss of vision [corrected].
authors.forename: J B
authors.initials: JB
authors.lastname: Selhorst
authors.forename: R F
authors.initials: RF
authors.lastname: Saul
mesh_terms: D001831:Body Temperature; D005074:Evoked Potentials, Visual / Q000502:physiology; D015444:Exercise; D005858:Germany; D049672:History, 19th Century; D049673:History, 20th Century; D006801:Humans; D009103:Multiple Sclerosis / Q000266:history* / Q000503:physiopathology; D009885:Ophthalmology / Q000266:history; D009902:Optic Neuritis / Q000266:history* / Q000503:physiopathology; D014786:Vision Disorders / Q000266:history* / Q000503:physiopathology