title: Identification of a pharmacophore for nucleoside analog inhibitors directed at HIV-1 reverse transcriptase.
abstract: An 'active analog' approach to receptor mapping was used to identify a pharmacophore for a set of thymidine nucleoside analog inhibitors of HIV-1 reverse transcriptase. The preliminary results indicate that the O2, O4', and O5' atoms are capable of adopting a unique pharmacophoric pattern which may be the key to their recognition by reverse transcriptase.
authors.affiliation: Department Biochemistry and Molecular Biology, UMDNJ New Jersey Medical School, Newark 07103.
authors.forename: M A
authors.initials: MA
authors.lastname: Fisher
authors.forename: P N
authors.initials: PN
authors.lastname: Yadav
authors.forename: J
authors.initials: J
authors.lastname: Yadav
authors.forename: D
authors.initials: D
authors.lastname: Kristol
authors.forename: E
authors.initials: E
authors.lastname: Arnold
authors.forename: M J
authors.initials: MJ
authors.lastname: Modak
mesh_terms: D001665:Binding Sites; D003196:Computer Graphics; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology; D008958:Models, Molecular; D009705:Nucleosides / Q000737:chemistry / Q000494:pharmacology*; D018894:Reverse Transcriptase Inhibitors; D013329:Structure-Activity Relationship; D013936:Thymidine
chemical_list: D009705:Nucleosides; D018894:Reverse Transcriptase Inhibitors; D054303:HIV Reverse Transcriptase; D013936:Thymidine