Comparison of the antiviral activities of 3'-azido-3'-deoxythymidine (AZT) and gossylic iminolactone (GIL) against clinical isolates of HIV-1.
3'-Azido-3'-deoxythymidine (AZT) and gossylic iminolactone (GIL) were compared for antiviral activities in vitro against fresh clinical isolates of HIV-1 obtained from 19 subjects on AZT therapy. IC50 values for AZT ranged from 0.015 to 6.7 microM (447-fold range) while IC50 values for GIL ranged from 0.40 to 6.6 microM (16-fold range). There was no correlation between IC50 values for AZT and GIL, suggesting that the anti-HIV activity of GIL does not involve inhibition of reverse transcriptase.
Royer
R E
RE
Department of Biochemistry, University of New Mexico School of Medicine, Albuquerque 87131, USA.
Mills
R G
RG
Young
S A
SA
Vander Jagt
D L
DL
D000163:Acquired Immunodeficiency Syndrome / Q000821:virology; D000998:Antiviral Agents / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D006072:Gossypol / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D054303:HIV Reverse Transcriptase; D015497:HIV-1 / Q000187:drug effects* / Q000201:enzymology; D006801:Humans; D018894:Reverse Transcriptase Inhibitors; D015215:Zidovudine / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D018894:Reverse Transcriptase Inhibitors; C073919:gossylic iminolactone; D015215:Zidovudine; D054303:HIV Reverse Transcriptase; D006072:Gossypol