The genetics of hypertension.
In the past few years, a number of key insights have been made concerning the genetic basis of hypertension and blood pressure regulation. The genes responsible for two Mendelian forms of hypertension, glucocorticoid-remediable aldosteronism and Liddle's syndrome, were identified. In addition, research into the role of the renin-angiotensin system in blood pressure regulation has further implicated the angiotensinogen and angiotensin-converting enzyme loci in hypertension and its complications, such as myocardial infarction. Finally, several new candidate genes for hypertension have been identified through the use of genome scanning and contemporary gene expression assays in model organisms.
Thibonnier
M
M
Department of Medicine, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA.
Schork
N J
NJ
D000808:Angiotensinogen / Q000235:genetics; D000818:Animals; D001794:Blood Pressure / Q000235:genetics; D004195:Disease Models, Animal; D015870:Gene Expression; D008040:Genetic Linkage; D014644:Genetic Variation; D016678:Genome; D005938:Glucocorticoids / Q000627:therapeutic use; D006801:Humans; D006929:Hyperaldosteronism / Q000188:drug therapy / Q000235:genetics; D006973:Hypertension / Q000235:genetics*; D007008:Hypokalemia / Q000235:genetics; D051379:Mice; D008822:Mice, Transgenic; D007703:Peptidyl-Dipeptidase A / Q000235:genetics; D051381:Rats; D011945:Receptors, Angiotensin / Q000235:genetics; D013577:Syndrome
D005938:Glucocorticoids; D011945:Receptors, Angiotensin; D000808:Angiotensinogen; D007703:Peptidyl-Dipeptidase A