Additional copies of 1q in sequential samples from a phyllodes tumor of the breast.
Cytogenetic and fluorescent in situ hybridization (FISH) analysis has been performed on consecutive samples, taken 4 weeks apart, from a phyllodes breast tumor. This revealed the presence of two different chromosome 1 derivatives, namely a dic(1;10)(q10;q24) in the first sample and an i(1) (q10) in the second. In one cell out of 25 from the second sample both derivative chromosomes were seen. A chromosome 21 was lost in both samples. These results are consistent with phyllodes tumors having a clonal origin.
Birdsall
S H
SH
Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, UK.
Summersgill
B M
BM
Egan
M
M
Fentiman
I S
IS
Gusterson
B A
BA
Shipley
J M
JM
D000368:Aged; D001943:Breast Neoplasms / Q000235:genetics*; D002878:Chromosomes, Human, Pair 1; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D003557:Phyllodes Tumor / Q000235:genetics*; D014178:Translocation, Genetic