title: Receptor endocytosis and dendrite reshaping in spinal neurons after somatosensory stimulation.
abstract: In vivo somatosensory stimuli evoked the release of substance P from primary afferent neurons that terminate in the spinal cord and stimulated endocytosis of substance P receptors in rat spinal cord neurons. The distal dendrites that showed substance P receptor internalization underwent morphological reorganization, changing from a tubular structure to one characterized by swollen varicosities connected by thin segments. This internalization and dendritic structural reorganization provided a specific image of neurons activated by substance P. Thus receptor internalization can drive reversible structural changes in central nervous system neurons in vivo. Both of these processes may be involved in neuronal plasticity.
authors.affiliation: Molecular Neurobiology Laboratory, Veterans Administration Medical Center, Minneapolis, MN 55417, USA.
authors.forename: P W
authors.initials: PW
authors.lastname: Mantyh
authors.forename: E
authors.initials: E
authors.lastname: DeMaster
authors.forename: A
authors.initials: A
authors.lastname: Malhotra
authors.forename: J R
authors.initials: JR
authors.lastname: Ghilardi
authors.forename: S D
authors.initials: SD
authors.lastname: Rogers
authors.forename: C R
authors.initials: CR
authors.lastname: Mantyh
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: A I
authors.initials: AI
authors.lastname: Basbaum
authors.forename: S R
authors.initials: SR
authors.lastname: Vigna
authors.forename: J E
authors.initials: JE
authors.lastname: Maggio
mesh_terms: D000818:Animals; D002211:Capsaicin / Q000494:pharmacology; D003712:Dendrites / Q000378:metabolism / Q000648:ultrastructure*; D004705:Endocytosis; D019204:GTP-Binding Proteins / Q000378:metabolism; D008297:Male; D009473:Neuronal Plasticity; D009474:Neurons / Q000378:metabolism* / Q000648:ultrastructure; D010812:Physical Stimulation; D051381:Rats; D017207:Rats, Sprague-Dawley; D018040:Receptors, Neurokinin-1 / Q000378:metabolism*; D013116:Spinal Cord / Q000166:cytology / Q000378:metabolism*; D013373:Substance P / Q000494:pharmacology
chemical_list: D018040:Receptors, Neurokinin-1; D013373:Substance P; D019204:GTP-Binding Proteins; D002211:Capsaicin