title: Patient selection and remission rates with the current practice of electroconvulsive therapy in Germany.
abstract: The current practice of German psychiatric hospitals restricts electroconvulsive therapy (ECT) to patients with profound disability and failure to respond to pharmacotherapy. We studied clinical features and seizure parameters in 63 patients who received ECT in a 3-year period at a German university hospital. Patients with unipolar and bipolar disorder (depressed) (n = 47) showed a complete or partial recovery as assessed 2 weeks after completion of the ECT course in 31.9 and 38.3%, respectively. Multiple linear regression analysis performed on several clinical and ECT seizure parameters failed to identify strong outcome predictors in our selected sample of patients. Most patients who eventually responded did so early in the course of ECT, while there was little improvement when > 10 ECT treatments were given. Our report highlights the efficacy of ECT in the management of severe psychiatric disorders even in a highly selected sample of patients previously found to be resistant to alternative modes of psychiatric treatment.
authors.affiliation: Department of Psychiatry, University of Würzburg, Germany.
authors.forename: J
authors.initials: J
authors.lastname: Kornhuber
authors.forename: M
authors.initials: M
authors.lastname: Weller
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D001714:Bipolar Disorder / Q000628:therapy*; D003866:Depressive Disorder / Q000628:therapy*; D004351:Drug Resistance; D004565:Electroconvulsive Therapy / Q000009:adverse effects; D005260:Female; D005858:Germany; D006801:Humans; D008297:Male; D008875:Middle Aged; D018579:Patient Selection; D012044:Regression Analysis; D012737:Sex Factors; D016896:Treatment Outcome