title: Acidogenicity of high-intensity sweeteners and polyols.
abstract: OBJECTIVE
  To evaluate the plaque pH responses to sucrose, fructose, xylitol, sorbitol, acesulfame-K, aspartame, and saccharin at equal sweetness levels (equivalent to 10% sucrose) and water using an indwelling plaque pH telemetry system.
  
  
  METHODS
  Eight adult panelists used each sweetener once in a Latin square study design. Plaque was allowed to accumulate for 3-6 days before each challenge period, and the panelists fasted for 12 hours prior to the 2-minute test rinse. Plaque pH was monitored for a 2-hour period after the rinse exposure. The parameters examined were area of the curves under pH 5.5 (pH X Time), pH changes from baseline, lowest pH attained and time below pH 5.5.
  
  
  RESULTS
  The the high-intensity sweeteners (aspartame, saccharin and acesulfame-K) and the polyols (sorbitol and xylitol) were all non-acidogenic and were not significantly different from each other while both sucrose and fructose were highly acidogenic.
authors.affiliation: Oral Health Research Institute, Indiana University School of Dentistry, Indianapolis 46202, USA.
authors.forename: K K
authors.initials: KK
authors.lastname: Park
authors.forename: B R
authors.initials: BR
authors.lastname: Schemehorn
authors.forename: G K
authors.initials: GK
authors.lastname: Stookey
authors.forename: H H
authors.initials: HH
authors.lastname: Butchko
authors.forename: P G
authors.initials: PG
authors.lastname: Sanders
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001218:Aspartame / Q000494:pharmacology; D003773:Dental Plaque / Q000737:chemistry* / Q000378:metabolism*; D004037:Diet, Cariogenic; D005632:Fructose / Q000494:pharmacology; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008875:Middle Aged; D012439:Saccharin / Q000494:pharmacology; D013012:Sorbitol / Q000494:pharmacology; D013395:Sucrose / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology*; D013843:Thiazines / Q000494:pharmacology; D014993:Xylitol / Q000494:pharmacology
chemical_list: D013549:Sweetening Agents; D013843:Thiazines; D005632:Fructose; D013012:Sorbitol; D013395:Sucrose; D012439:Saccharin; C006362:acetosulfame; D014993:Xylitol; D001218:Aspartame