title: A disulphide-reinforced structural scaffold shared by small proteins with diverse functions.
abstract: We describe the T-knot scaffold, a structural feature shared by the EGF-like proteins, alpha-toxins and proteinase inhibitors from plants.
authors.forename: S L
authors.initials: SL
authors.lastname: Lin
authors.forename: R
authors.initials: R
authors.lastname: Nussinov
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002268:Carboxypeptidases / Q000037:antagonists & inhibitors; D004220:Disulfides / Q000737:chemistry*; D004815:Epidermal Growth Factor / Q000737:chemistry; D005164:Factor IX / Q000737:chemistry; D006801:Humans; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D010940:Plant Proteins / Q000737:chemistry; D011480:Protease Inhibitors / Q000737:chemistry; D011487:Protein Conformation; D011506:Proteins / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid; D014118:Toxins, Biological / Q000737:chemistry
chemical_list: D004220:Disulfides; D010940:Plant Proteins; D011480:Protease Inhibitors; D011506:Proteins; D014118:Toxins, Biological; D004815:Epidermal Growth Factor; D005164:Factor IX; D002268:Carboxypeptidases