title: The gene coding for the B cell surface protein CD19 is localized on human chromosome 16p11.
abstract: The CD19 gene codes for one of the earliest markers of the human B cell lineage and is a target for the B lymphoid-specific transcription factor BSAP (Pax-5). The transmembrane protein CD19 has been implicated in controlling proliferation of mature B lymphocytes by modulating signal transduction through the antigen receptor. In this study, we have employed Southern blot and fluorescence in situ hybridization analyses to localize the CD19 gene to human chromosome 16p11.
authors.affiliation: Research Institute of Molecular Pathology, Vienna, Austria.
authors.forename: P
authors.initials: P
authors.lastname: Stapleton
authors.forename: Z
authors.initials: Z
authors.lastname: Kozmik
authors.forename: A
authors.initials: A
authors.lastname: Weith
authors.forename: M
authors.initials: M
authors.lastname: Busslinger
mesh_terms: D000818:Animals; D015703:Antigens, CD / Q000235:genetics*; D018941:Antigens, CD19; D000944:Antigens, Differentiation, B-Lymphocyte / Q000235:genetics*; D002874:Chromosome Mapping; D002885:Chromosomes, Human, Pair 16; D006224:Cricetinae; D003412:Cricetulus; D008040:Genetic Linkage; D006801:Humans; D006822:Hybrid Cells; D017404:In Situ Hybridization, Fluorescence; D051379:Mice
chemical_list: D015703:Antigens, CD; D018941:Antigens, CD19; D000944:Antigens, Differentiation, B-Lymphocyte