[Effects of ileal perfusion of carbohydrates on upper GI motility and pancreatic exocrine secretion].
The aim of this study was to determine if upper gut function and pancreatic exocrine secretion are affected by the presence of unabsorbed carbohydrate in the distal ileum. In this investigation, starch or glucose was perfused into the canine ileum. This study showed that ileal perfusion of both starch and glucose delayed gastric emptying and prolonged small bowel transit time. Furthermore, glucose had greater effects on gastrointestinal transit time than starch. In contrast, amylase output was increased by ileal perfusion of starch, but was not affected by that of glucose. Our results suggest that the ileal regulation of gastrointestinal transit and amylase output could be mediated by different mechanisms.
Shinagawa
H
H
First Department of Internal Medicine, School of Medicine, Hirosaki University.
Tohno
H
H
Baba
T
T
Munakata
A
A
Yoshida
Y
Y
D000681:Amylases / Q000378:metabolism; D000818:Animals; D004285:Dogs; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D005769:Gastrointestinal Motility / Q000187:drug effects*; D005772:Gastrointestinal Transit / Q000187:drug effects; D005947:Glucose / Q000494:pharmacology*; D007082:Ileum; D008297:Male; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism*; D010477:Perfusion; D013213:Starch / Q000494:pharmacology
D013213:Starch; D000681:Amylases; D005947:Glucose