Effect of oxatomide nasal spray on experimental allergic rhinitis in guinea pigs and rats.
We investigated the effect of topically applied oxatomide, an antiallergic agent, on the assault of allergic rhinitis in actively sensitized guinea pigs. Topical application of oxatomide nasal spray (0.025%) reduced the severity of allergic rhinitis which was assessed by determining dye leakage and histamine released to the nasal cavity of guinea pigs. Furthermore, oxatomide nasal spray treatment significantly prevented the increase in dye leakage induced by histamine administration in guinea pigs and rats. These results indicate that the topical application of oxatomide inhibits both the release and the action of histamine. Therefore, oxatomide nasal spray may be beneficial for treatment of allergic rhinitis.
Kaise
T
T
Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd, Shizuoka, Japan.
Ohmori
K
K
Ukai
K
K
Sakakura
Y
Y
D000281:Administration, Intranasal; D000818:Animals; D006168:Guinea Pigs; D006634:Histamine H1 Antagonists / Q000627:therapeutic use*; D006636:Histamine Release / Q000187:drug effects; D008297:Male; D010879:Piperazines / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012221:Rhinitis, Allergic, Perennial / Q000188:drug therapy*
D006634:Histamine H1 Antagonists; D010879:Piperazines; C015408:oxatomide