HLA and anti-GQ1b IgG antibody in Miller Fisher syndrome and Guillain-Barré syndrome.
We investigated serological human leukocyte antigen (HLA) types in patients with histories of Miller Fisher syndrome (MFS) and Guillain-Barré syndrome (GBS) with ophthalmoplegia, in whom serum anti-GQ1b IgG antibody was present during the acute phase. We examined class I antigens (A, B and C) in 32 patients and class II antigens (DR and DQ) in 30, but found no association. We conclude that particular serologically defined HLA types are not preferred for the immunoresponse of anti-GQ1b IgG antibody in MFS and GBS.
Chiba
A
A
Department of Neurology, School of Medicine, University of Tokyo, Japan.
Kusunoki
S
S
Kuwata
S
S
Juji
T
T
Shibata
Y
Y
Kanazawa
I
I
D001323:Autoantibodies / Q000276:immunology*; D001324:Autoantigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000276:immunology*; D005732:Gangliosides / Q000276:immunology*; D006680:HLA Antigens / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000276:immunology; D011129:Polyradiculoneuropathy / Q000276:immunology*
D001323:Autoantibodies; D001324:Autoantigens; D005732:Gangliosides; D006680:HLA Antigens; D007074:Immunoglobulin G; C039129:GQ1b ganglioside