title: Samarium-153-EDTMP for palliation of ankylosing spondylitis, Paget's disease and rheumatoid arthritis.
abstract: Samarium-153-EDTMP is an effective agent for palliation of widespread skeletal metastases because it concentrates in bone metastases which have an osteoblastic component. Similar concentration in areas of osteoblastic activity in ankylosing spondylitis, Paget's disease and rheumatoid arthritis suggests a possible new treatment approach. Three patients with ankylosing spondylitis, one patient with Paget's disease and one patient with rheumatoid arthritis were treated with 153Sm-EDTMP. Objective and subjective improvement was noted, especially in ankylosing spondylitis patients. Samarium-153-EDTMP has disease-modifying potential in ankylosing spondylitis and Paget's disease and has palliative value in resistant rheumatoid arthritis. Further trials to determine optimal dose, treatment scheduling, long-term disease-modifying potential and toxicity are needed.
authors.affiliation: Department of Radiotherapy, H.F. Verwoerd Hospital, University of Pretoria, South Africa.
authors.forename: A S
authors.initials: AS
authors.lastname: Alberts
authors.forename: S W
authors.initials: SW
authors.lastname: Brighton
authors.forename: P
authors.initials: P
authors.lastname: Kempff
authors.forename: W K
authors.initials: WK
authors.lastname: Louw
authors.forename: A V
authors.initials: AV
authors.lastname: Beek
authors.forename: V
authors.initials: V
authors.lastname: Kritzinger
authors.forename: H P
authors.initials: HP
authors.lastname: Westerink
authors.forename: A J
authors.initials: AJ
authors.lastname: van Rensburg
mesh_terms: D001172:Arthritis, Rheumatoid / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009942:Organometallic Compounds / Q000627:therapeutic use*; D009943:Organophosphorus Compounds / Q000627:therapeutic use*; D010001:Osteitis Deformans / Q000532:radiotherapy*; D010147:Pain Measurement; D010166:Palliative Care / Q000379:methods*; D011868:Radioisotopes / Q000627:therapeutic use*; D012493:Samarium / Q000627:therapeutic use*; D013167:Spondylitis, Ankylosing / Q000532:radiotherapy*; D013997:Time Factors
chemical_list: D009942:Organometallic Compounds; D009943:Organophosphorus Compounds; D011868:Radioisotopes; D012493:Samarium; C061972:samarium Sm-153 lexidronam