title: Long-term results of the gamma-irradiation-preserved homograft monocusp for transannular reconstruction of the right-ventricular outflow tract in tetralogy of Fallot.
abstract: The long-term results of a consecutive series of transannular gamma-irradiated homograft monocusp patches in tetralogy of Fallot were studied. Seven survivors out of 8 patients are doing clinically well after a mean of 22.4 years of follow-up, 5 of them being in New York Heart Association class I and 2 in class II. In one patient the completely calcified gamma-irradiated homograft monocusp patch was replaced 15 years after intracardiac repair. Echocardiographic investigation at the end of follow-up of the remaining 6 patients with a gamma-irradiated homograft monocusp patch in situ showed mild pulmonary regurgitation in 1, moderate regurgitation in 3, and severe regurgitation in 2. Residual pulmonary stenosis was present in 4 patients (gradients ranging from 10 to 40 mmHg). Right-ventricular dilatation was present in all patients. In the long-term the gamma-irradiated transannular homograft monocusp patch behaves like a simple transannular patch.
authors.affiliation: Department of Thoracic Surgery, University Hospital Sophia/Dijkzigt, Rotterdam, The Netherlands.
authors.forename: A J
authors.initials: AJ
authors.lastname: Bogers
authors.forename: M
authors.initials: M
authors.lastname: Roofthooft
authors.forename: H
authors.initials: H
authors.lastname: Pisters
authors.forename: S E
authors.initials: SE
authors.lastname: Spitaels
authors.forename: E
authors.initials: E
authors.lastname: Bos
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D005260:Female; D005500:Follow-Up Studies; D005720:Gamma Rays / Q000627:therapeutic use; D006801:Humans; D008297:Male; D011664:Pulmonary Valve / Q000637:transplantation*; D012189:Retrospective Studies; D017741:Survivors; D013771:Tetralogy of Fallot / Q000401:mortality / Q000601:surgery*; D013997:Time Factors; D014021:Tissue Preservation / Q000379:methods*; D014184:Transplantation, Homologous; D014694:Ventricular Outflow Obstruction / Q000401:mortality / Q000601:surgery*