[Computed morpho-densitometry and its possibilities in experimental and clinical studies].
The paper deals with the automatic morphodensitometric analysis of various biomedical objects (such as interphase chromatin in the cellular nuclei of chondroblasts and lymphocytes or human peripheral blood, opacities in the lens of chick embryos. A complex algorhythm of computational image processing was created for submolecular restructuring of interphase chromatin cell nuclear examinations. It includes specific methods of staining and unifies different quantitative analytical methods: photometrical, geometrical, gradiental, informational, and statistical. The blood cells of the children who had received low-dose radiation were detected by employing a new method of TV image computational processing of DNA-stained lymphocytes. The approach demonstrated by this study provides a sensitive and meaningful mean for diagnosing human diseases and can be useful in the clinical setting.
Kogan
E M
EM
Zhukotskiĭ
A V
AV
Kopylov
V F
VF
Lomakin
O A
OA
Molodtsov
M Iu
MIu
Putina
T G
TG
Chernysh
S A
SA
D000293:Adolescent; D000328:Adult; D000465:Algorithms; D000818:Animals; D002356:Cartilage / Q000166:cytology; D002386:Cataract / Q000175:diagnosis / Q000473:pathology; D002642:Chick Embryo; D002648:Child; D002675:Child, Preschool; D002843:Chromatin / Q000648:ultrastructure; D004247:DNA / Q000032:analysis; D003720:Densitometry; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007399:Interphase; D008214:Lymphocytes / Q000166:cytology / Q000528:radiation effects; D010783:Photometry; D011829:Radiation Dosage; D013194:Staining and Labeling; D014057:Tomography, X-Ray Computed
D002843:Chromatin; D004247:DNA