Hypoadrenocorticism in a family of leonbergers.
Hypoadrenocorticism was diagnosed in four related leonbergers. Two of the four dogs also had low-resting serum thyroxine (T4) levels and signs consistent with hypothyroidism. The familial association of the affected dogs and the presence of coexisting thyroid dysfunction are similar to what is seen in human type II polyglandular autoimmune syndrome.
Smallwood
L J
LJ
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
Barsanti
J A
JA
D000305:Adrenal Cortex Hormones / Q000627:therapeutic use; D000309:Adrenal Insufficiency / Q000175:diagnosis / Q000188:drug therapy / Q000235:genetics / Q000662:veterinary*; D000818:Animals; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000235:genetics; D004285:Dogs; D004359:Drug Therapy, Combination; D005260:Female; D010375:Pedigree; D013974:Thyroxine / Q000097:blood
D000305:Adrenal Cortex Hormones; D013974:Thyroxine