title: Diagnostic significance of prostate specific antigen and the development of a mass screening system for prostate cancer.
abstract: OBJECTIVE
  The significance of prostate specific antigen (PSA) in the mass screening for prostate cancer was investigated.
  
  
  METHODS
  A total of 4,375 PSA, digital rectal and transrectal ultrasonographic examinations was performed on 3,526 subjects.
  
  
  RESULTS
  Among the 3 modalities, PSA had the highest sensitivity (80.4%) and positive predictive value (45.1%). We established age-specific reference PSA ranges for normal Japanese men, and demonstrated the significance of PSA density and PSA velocity.
  
  
  CONCLUSIONS
  The significance of PSA as a prostate cancer screening modality should be evaluated across multiple age ranges and in combination with previous PSA data and/or prostate volume.
authors.affiliation: Department of Urology, Gunma University School of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Imai
authors.forename: Y
authors.initials: Y
authors.lastname: Ichinose
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: H
authors.initials: H
authors.lastname: Yamanaka
authors.forename: J
authors.initials: J
authors.lastname: Sato
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D008297:Male; D008403:Mass Screening / Q000379:methods*; D008875:Middle Aged; D010173:Palpation; D017430:Prostate-Specific Antigen / Q000097:blood*; D011471:Prostatic Neoplasms / Q000175:diagnosis* / Q000000981:diagnostic imaging; D012680:Sensitivity and Specificity; D014463:Ultrasonography
chemical_list: D017430:Prostate-Specific Antigen