MELAS syndrome associated with diabetes mellitus and hyperthyroidism: a case report from Taiwan.
MELAS syndrome is a form of mitochondrial myopathy with manifestations of seizure, stroke-like syndrome, lactic acidosis, ragged red muscle fibres and mitochondrial encephalopathy. The syndrome has been reported in association with a variety of endocrine and metabolic disorders including diabetes mellitus (DM), hypothalamo-pituitary hypofunction, hypothalamic growth hormone deficiency and delayed puberty. Mitochondrial DNA (mtDNA) point mutation may be the major pathological defect. However, association of MELAS syndrome with hyperthyroidism has not previously been reported. A case is reported from Taiwan of a 32-year-old woman suffering from MELAS syndrome with associated DM and hyperthyroidism. When the latter was diagnosed in April 1988, the patient underwent subtotal thyroidectomy. There was no family history of thyroid disease. Because of repeated seizures, she had computed tomography (CT) and magnetic resonance imaging (MRI) of the brain which showed focal, low-density lesions over the cerebral hemispheres. Both serum and cerebral spinal fluid lactic acid levels were elevated. Mild elevations of serum T4 and T3 and a high titre of TSH receptor antibody were still present. Hyperglycaemia was noted during hospitalization and DM confirmed by oral glucose tolerance test. Muscle biopsy showed ragged red fibres. DNA analysis showed an A-to-G transition at the 3243rd nucleotide position of the tRNA(Leu(UUR)) gene of the mtDNA from the patient. Quantitative polymerase chain reaction (PCR) and restriction analysis revealed that about 60% of the blood mtDNA was of mutant type. The patient received antithyroid drugs for hyperthyroidism, diet control for DM and anti-epileptic drugs for seizure.
Yang
C Y
CY
Department of Medicine, National Yang-Ming University, Kaohsiung, Taiwan, Republic of China.
Lam
H C
HC
Lee
H C
HC
Wei
Y H
YH
Lu
C C
CC
Han
T M
TM
Tsai
J L
JL
Chuang
Y H
YH
Lee
J K
JK
D000328:Adult; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006980:Hyperthyroidism / Q000150:complications* / Q000000981:diagnostic imaging; D017241:MELAS Syndrome / Q000150:complications*; D014057:Tomography, X-Ray Computed