title: The spatial localization of Dlx-2 during tooth development.
abstract: The spatial distribution of Dlx-2 protein during murine tooth development has been investigated using immunohistochemistry with Dlx-2 antibodies. In common with several other homeobox genes expressed in toothgerms, Dlx-2 shows a multiphasic distribution in both epithelially and mesenchymally derived structures. This localization shows a number of similarities with the expression of Msx-2 and suggests a role for Dlx-2 in tooth initiation and tissue patterning.
authors.affiliation: Department of Craniofacial Development, UMDS, Guy's Hospital, London, U.K.
authors.forename: B L
authors.initials: BL
authors.lastname: Thomas
authors.forename: M H
authors.initials: MH
authors.lastname: Porteus
authors.forename: J L
authors.initials: JL
authors.lastname: Rubenstein
authors.forename: P T
authors.initials: PT
authors.lastname: Sharpe
mesh_terms: D000565:Ameloblasts / Q000378:metabolism / Q000648:ultrastructure; D000818:Animals; D000906:Antibodies; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins / Q000235:genetics*; D003771:Dental Papilla / Q000378:metabolism / Q000648:ultrastructure; D004475:Ectoderm / Q000378:metabolism / Q000648:ultrastructure; D004848:Epithelium / Q000378:metabolism / Q000648:ultrastructure; D018507:Gene Expression Regulation, Developmental; D005801:Genes, Homeobox / Q000235:genetics*; D018398:Homeodomain Proteins; D007150:Immunohistochemistry; D008648:Mesoderm / Q000378:metabolism / Q000648:ultrastructure; D051379:Mice; D008807:Mice, Inbred BALB C; D009805:Odontogenesis / Q000235:genetics*; D011506:Proteins / Q000235:genetics*; D016601:RNA-Binding Proteins; D014083:Tooth Germ / Q000378:metabolism / Q000648:ultrastructure; D014157:Transcription Factors
chemical_list: D000906:Antibodies; D003598:Cytoskeletal Proteins; D004268:DNA-Binding Proteins; C088334:Distal-less homeobox proteins; D018398:Homeodomain Proteins; C084119:MSX2 protein; D011506:Proteins; D016601:RNA-Binding Proteins; C093661:Tes protein, mouse; D014157:Transcription Factors