title: Tau protein concentrations in cerebrospinal fluid of patients with dementia of the Alzheimer type.
abstract: Tau protein concentrations were measured in the CSF of 23 patients with dementia of the Alzheimer type (DAT), 36 patients with multi-infarct dementia (MID), and 23 control subjects. Tau protein concentrations were significantly higher in patients with DAT than in controls (P < 0.001) and patients with MID (P < 0.001). A significantly positive correlation between CSF tau protein and glucose concentrations (r = 0.79, P < 0.001) and evolution of disease (r = 0.47, P < 0.05), and a negative correlation with Folstein's mental state examination test (r = -0.73, P < 0.001) were found in patients with DAT.
authors.affiliation: Servicio de Bioquímica, Hospital La Paz, Madrid, Spain.
authors.forename: R E
authors.initials: RE
authors.lastname: Tato
authors.forename: A
authors.initials: A
authors.lastname: Frank
authors.forename: A
authors.initials: A
authors.lastname: Hernanz
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000134:cerebrospinal fluid*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009478:Neuropeptide Y / Q000134:cerebrospinal fluid; D013004:Somatostatin / Q000134:cerebrospinal fluid; D013373:Substance P / Q000134:cerebrospinal fluid; D016875:tau Proteins / Q000134:cerebrospinal fluid*
chemical_list: D009478:Neuropeptide Y; D016875:tau Proteins; D013373:Substance P; D013004:Somatostatin