title: Potential role of Fc gamma R in early development of murine lymphoid cells: evidence for functional interaction between Fc gamma R on pre-thymocytes and an alternative, non-Ig ligand on thymic stromal cells.
abstract: During early development of the murine fetal thymus a fraction of Thy+ thymocytes express Fc gamma receptors. Concurrently, a small fraction of Thy- CD44- thymocytes bind recombinant soluble Fc gamma R. These findings suggested the possibility that Fc gamma R+ pre-T cells interact with a non-Ig ligand present on fetal thymic stromal cells. Evidence in support of this concept was the finding that experimental manipulation of this putative receptor-ligand pair by anti-receptor antibody or recombinant soluble Fc gamma R influenced the developmental pattern of alpha/beta-TCR+ T cells. The restricted expression of CD16 on some pre-B cells raises the possibility that an Fc gamma R-dependent step may play a similar role in B-cell development.
authors.affiliation: Department of Pathology, University of Iowa College of Medicine, Iowa City 52242, USA.
authors.forename: R G
authors.initials: RG
authors.lastname: Lynch
authors.forename: M
authors.initials: M
authors.lastname: Hagen
authors.forename: A
authors.initials: A
authors.lastname: Mueller
authors.forename: M
authors.initials: M
authors.lastname: Sandor
mesh_terms: D000818:Animals; D016175:B-Lymphocyte Subsets / Q000276:immunology; D002352:Carrier Proteins / Q000096:biosynthesis; D002454:Cell Differentiation; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D018960:Hyaluronan Receptors; D008024:Ligands; D008214:Lymphocytes / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological; D011956:Receptors, Cell Surface / Q000096:biosynthesis; D017452:Receptors, IgG / Q000096:biosynthesis / Q000276:immunology*; D016201:Receptors, Lymphocyte Homing / Q000096:biosynthesis; D016176:T-Lymphocyte Subsets / Q000276:immunology; D013950:Thymus Gland / Q000196:embryology / Q000276:immunology*
chemical_list: D002352:Carrier Proteins; D018960:Hyaluronan Receptors; D008024:Ligands; D011956:Receptors, Cell Surface; D017452:Receptors, IgG; D016201:Receptors, Lymphocyte Homing