Cloning of a cGMP-gated cation channel from mouse kidney inner medullary collecting duct.
The cDNA sequence coding for the cGMP-gated cation channel expressed in the mouse kidney inner medullary collecting duct has been determined. The kidney cGMP-gated cation channel cDNA has an open reading frame of 2055 nucleotides and encodes a 685 amino acid protein. One cDNA clone is alternatively spliced thereby producing a deletion of 107 bp. Two differentially spliced 5' untranslated regions were determined by 5' RACE.
Karlson
K H
KH
Department of Physiology, Dartmouth Medical School, Hanover, NH 03755, USA.
Ciampolillo-Bates
F
F
McCoy
D E
DE
Kizer
N L
NL
Stanton
B A
BA
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D006152:Cyclic GMP / Q000378:metabolism*; D054815:Cyclic Nucleotide-Gated Cation Channels; D007473:Ion Channels / Q000037:antagonists & inhibitors / Q000096:biosynthesis* / Q000737:chemistry; D007679:Kidney Medulla / Q000378:metabolism*; D007685:Kidney Tubules, Collecting / Q000378:metabolism*; D051379:Mice; D008969:Molecular Sequence Data; D012374:Rod Cell Outer Segment / Q000378:metabolism
D054815:Cyclic Nucleotide-Gated Cation Channels; D007473:Ion Channels; D006152:Cyclic GMP