The effects of roxatidine on neuromuscular transmission.
We have investigated the effects of the H2 receptor antagonist roxatidine on the neuromuscular transmission by using the sciatic nerve-gastrocnemius muscle preparation of the rat in vivo. Roxatidine, administered by i.v. injection, potentiates the neuromuscular blockade induced by d-tubocurarine, pancuronium and aminoglycoside antibiotic, kanamycin. Moreover, the drug alone is capable of producing a blockade on the preparation stimulated at high frequency. The neuromuscular blockade induced by roxatidine is partially reversed by 4-aminopyridine but not by dimaprit.
Bossa
R
R
Dipartimento di Farmacologia, Chemioterapia e Tossicologia Medica Emilio Trabucchi, Università di Milano, Italy.
Chiericozzi
M
M
Galatulas
I
I
Salvatore
G
G
Teli
M
M
Baggio
G
G
Castelli
M
M
D015761:4-Aminopyridine / Q000494:pharmacology; D000818:Animals; D017259:Dimaprit / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D006635:Histamine H2 Antagonists / Q000494:pharmacology*; D007275:Injections, Intravenous; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology; D009469:Neuromuscular Junction / Q000187:drug effects*; D010880:Piperidines / Q000494:pharmacology*; D051381:Rats; D012584:Sciatic Nerve / Q000187:drug effects; D014403:Tubocurarine / Q000494:pharmacology
D006635:Histamine H2 Antagonists; D009466:Neuromuscular Blocking Agents; D010880:Piperidines; D015761:4-Aminopyridine; D014403:Tubocurarine; C053742:roxatidine acetate; D017259:Dimaprit