Pharmacokinetic interactions of alcohol and acetylsalicylic acid.
This study assessed the influence of acetylsalicylic acid (ASA, 1.0 g), ibuprofen (0.8 g) and paracetamol (1.0 g) on the single-dose kinetics of ethanol in 12 healthy volunteers ingesting the drug and a standardised 1840-kJ breakfast 1 h before intake of ethanol. It also assessed the influence of ethanol on the single-dose kinetics of 1.0 g ASA in ten fasting healthy volunteers. Plasma concentrations of ethanol were measured by gas chromatography, and those of the drugs by liquid chromatography. There was no effect of ASA, ibuprofen or paracetamol on the single-dose kinetics of ethanol, but concurrent intake of ethanol reduced the peak concentration of ASA by 25%.
Melander
O
O
Department of Clinical Pharmacology, Malmö University Hospital, Sweden.
Lidén
A
A
Melander
A
A
D000082:Acetaminophen / Q000493:pharmacokinetics; D000293:Adolescent; D000328:Adult; D001241:Aspirin / Q000493:pharmacokinetics*; D001682:Biological Availability; D004347:Drug Interactions; D000431:Ethanol / Q000493:pharmacokinetics*; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000493:pharmacokinetics; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D014838:Volunteers
D000082:Acetaminophen; D000431:Ethanol; D001241:Aspirin; D007052:Ibuprofen