Embolization of biologic glue during repair of aortic dissection.
A 72-year-old patient was operated on because of an acute type A aortic dissection with the primary entry located in the aortic arch and with retrograde involvement of the ascending aorta. Complete replacement of the aortic arch and the ascending aorta was performed after the dissected aortic layers had been readapted and sealed with gelatin-resorcin-formaldehyde biologic glue. Postoperative neurologic status was judged to be normal. The patient died 3 weeks postoperatively of septic shock. Postmortem examination of the brain revealed several small lesions, and microscopy showed very small particles of polymerized glue in the afferent vessels of ischemic cerebral and meningeal regions.
Carrel
T
T
Clinic for Cardiovascular Surgery, University Hospital, Zürich, Switzerland.
Maurer
M
M
Tkebuchava
T
T
Niederhäuser
U
U
Schneider
J
J
Turina
M I
MI
D000368:Aged; D000784:Aortic Dissection / Q000601:surgery*; D001014:Aortic Aneurysm / Q000601:surgery*; D001921:Brain; D002544:Cerebral Infarction / Q000209:etiology; D004338:Drug Combinations; D017809:Fatal Outcome; D005548:Foreign-Body Migration; D005557:Formaldehyde / Q000627:therapeutic use*; D005780:Gelatin / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011183:Postoperative Complications; D012118:Resorcinols / Q000627:therapeutic use*; D014014:Tissue Adhesives / Q000627:therapeutic use*
D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin