Putative capacitative calcium entry channels: expression of Drosophila trp and evidence for the existence of vertebrate homologues.
Capacitative calcium entry is a major pathway through which intracellular calcium stores are refilled after stimulation. It has been suggested that the protein encoded by the transient receptor potential (trp) gene expressed in Drosophila photoreceptors may be homologous with capacitative calcium entry channels. Expression of the trp gene product in Xenopus oocytes led to significant increases in calcium entry only when the intracellular calcium stores were depleted. Previous investigations have found trp to be uniquely expressed in Drosophila photoreceptors, but PCR cloning shows that homologous proteins exist in Calliphora, mouse brain and Xenopus oocytes. It is thus possible that capacitative calcium entry in Xenopus oocytes is mediated by a homologue of trp.
Petersen
C C
CC
Babraham Institute Laboratory of Molecular Signalling, Department of Zoology, University of Cambridge, U.K.
Berridge
M J
MJ
Borgese
M F
MF
Bennett
D L
DL
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D015220:Calcium Channels / Q000235:genetics* / Q000502:physiology; D002148:Calmodulin-Binding Proteins / Q000235:genetics* / Q000502:physiology; D004175:Diptera / Q000235:genetics; D004330:Drosophila; D029721:Drosophila Proteins; D005260:Female; D015870:Gene Expression; D007301:Insect Hormones / Q000235:genetics* / Q000502:physiology; D019476:Insect Proteins; D015640:Ion Channel Gating; D008565:Membrane Proteins / Q000235:genetics* / Q000502:physiology; D051379:Mice; D008969:Molecular Sequence Data; D009865:Oocytes / Q000378:metabolism; D016133:Polymerase Chain Reaction; D017385:Sequence Homology; D050051:Transient Receptor Potential Channels; D014981:Xenopus / Q000235:genetics
D015220:Calcium Channels; D002148:Calmodulin-Binding Proteins; D029721:Drosophila Proteins; D007301:Insect Hormones; D019476:Insect Proteins; D008565:Membrane Proteins; D050051:Transient Receptor Potential Channels; C063169:trp protein, Drosophila; C074192:trpl protein, Drosophila; D002118:Calcium