Novel solid-phase extraction strategy for the isolation of basic drugs from whole blood. Preliminary study using commercially available extraction cartridges.
A novel strategy for the solid-phase extraction of basic drugs has been developed using commercial extraction cartridges. The procedure involves the sequential application of very different isolation mechanisms, viz. hydrophobic extraction on non-porous carbon followed by ionic extraction on a strong cation exchanger. This approach to extraction achieves both high recoveries and clean extracts when analysed by GC-MS. The potential for automation has been demonstrated using commercial sample preparation equipment.
Cosbey
S H
SH
Northern Ireland Forensic Science Laboratory, Carrickfergus, UK.
Craig
I
I
Gill
R
R
D000327:Adsorption; D000818:Animals; D001774:Blood Chemical Analysis / Q000379:methods*; D002411:Cation Exchange Resins; D002845:Chromatography / Q000379:methods*; D008401:Gas Chromatography-Mass Spectrometry; D007099:Imipramine / Q000097:blood; D009661:Nortriptyline / Q000097:blood; D004364:Pharmaceutical Preparations / Q000302:isolation & purification*; D011433:Propranolol / Q000097:blood; D011803:Quinine / Q000097:blood; D012756:Sheep; D012995:Solubility
D002411:Cation Exchange Resins; D004364:Pharmaceutical Preparations; D011433:Propranolol; D011803:Quinine; D009661:Nortriptyline; D007099:Imipramine