In vitro activity of levofloxacin and FK-037 against aerobic isolates from spontaneous bacterial peritonitis.
Spontaneous bacterial peritonitis is a potentially fatal complication of ascites, most often caused by the Enterobacteriaceae or streptococci. We have evaluated the in vitro activity of FK-037, a new cephalosporin, cefotaxime, cefpirome, ceftazidime, levofloxacin, and ofloxacin against a collection of 124 isolates from patients with spontaneous bacterial peritonitis. Levofloxacin (< or = 2 mg/L) was active against all isolates and ofloxacin (< or = 2 mg/L) against 98.4% of isolates. The cephalosporins (< or = 8 mg/L) were less active against cefpirome = 95.4%, FK-037 = 94.4%, and cefotaxime and ceftazidime = 91.1%. Given the high mortality associated with spontaneous bacterial peritonitis, clinical studies of the quinolones (specifically of levofloxacin) and the alternative cephalosporins presented for treatment of spontaneous bacterial peritonitis appears warranted.
Cormican
M G
MG
Department of Internal Medicine, University of Iowa College of Medicine, Iowa City 52242, USA.
Runyon
B A
BA
Jones
R N
RN
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D001420:Bacteria, Aerobic / Q000187:drug effects*; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects; D006801:Humans; D007536:Isomerism; D064704:Levofloxacin; D008826:Microbial Sensitivity Tests; D015242:Ofloxacin / Q000494:pharmacology*; D010538:Peritonitis / Q000382:microbiology*; D013291:Streptococcus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; C079769:cefoselis; D064704:Levofloxacin; D015242:Ofloxacin; D015296:Ceftizoxime