title: Late and acute adverse reactions to iohexol in a pediatric population.
abstract: The purpose of this study was to determine the incidence of acute and late reactions after contrast-medium injection in the Finnish paediatric population. From March 1989 to November 1990, 321 children under 19 years of age were examined with a nonionic contrast medium, iohexol, for urography and CT. The follow-up time for late reactions was up to 24 h after the contrast-medium injection. The return rate for the questionnaires given to patients to record their reactions was 73.2%. Acute adverse reaction was noted in 1.9% of the patients, with the most frequent reactions being in the weight range 24-40 kg. Asthma and previous reaction to contrast medium are risk factors for acute reaction. Late reactions were found in 6.2% of the patients, most frequently in children weighing under 24 kg.
authors.affiliation: Department of Diagnostic Radiology, Helsinki University Hospital, Meilahti, University of Helsinki, Finland.
authors.forename: R
authors.initials: R
authors.lastname: Mikkonen
authors.forename: T
authors.initials: T
authors.lastname: Kontkanen
authors.forename: L
authors.initials: L
authors.lastname: Kivisaari
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced; D001835:Body Weight; D002675:Child, Preschool; D003287:Contrast Media / Q000009:adverse effects*; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006801:Humans; D007223:Infant; D007472:Iohexol / Q000009:adverse effects*; D008297:Male; D012307:Risk Factors; D014057:Tomography, X-Ray Computed; D014567:Urography
chemical_list: D003287:Contrast Media; D007472:Iohexol