[The effect of physical loading on the pharmacokinetics of drugs].
In model experiments on rats performed with the use of radioindication assay and the HPLG method it was shown that the total level of cholinolytics, pediphen (20 mg/kg) and peniphin (6 mg/kg) reliably decreases in plasma after oral administration during physical exercise (method of free swimming under loading). At the same time the intramuscular injection of pediphen (2 mg/kg) and peniphin (0.6 mg/kg) induce a reliable increase in the concentration of cholinolytics in plasma under the influence of physical exercise. The mechanism of observed changes in pharmacokinetics of neurotropic drugs are discussed. The results of this study may be used in therapy to optimize doses of cholinolytic drugs in conditions of physical and/or locomotor activity.
Elaeva
N L
NL
Predtechenskiĭ
M B
MB
Babaina
E V
EV
D000818:Animals; D018680:Cholinergic Antagonists / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D002853:Chromatography, Liquid / Q000295:instrumentation / Q000379:methods; D007273:Injections, Intramuscular; D008297:Male; D005082:Physical Exertion / Q000502:physiology*; D051381:Rats; D013550:Swimming; D013997:Time Factors; D014316:Tritium
D018680:Cholinergic Antagonists; D014316:Tritium
Vliianie fizicheskoĭ nagruzki na farmakokinetiku nekotorykh lekarstvennykh sredstv.