Spinal opioid systems in inflammation.
Until recently, basic science studies, both behavioural and electrophysiological, have concentrated on the antinociceptive actions of opioids primarily gauged against acute nociceptive responses. However, of more relevance to clinical situations are the actions of opioids in more persistent/prolonged pain states. This review sets out to examine the central actions of opioids against nociception of inflammatory origins. The first section deals with the response of the endogenous opioid system to the development of an inflammatory state and the second examines the ability of exogenous opioids to modulate inflammatory nociception. There are complex changes in the roles of endogenous opioids, in particular dynorphin, at the spinal level after inflammation although the physiological consequences remain unclear. With regard to exogenous opioids, the effectiveness of spinal morphine is rapidly enhanced after inflammation, likely to be due to changes in the interaction between the peptide cholecystokinin and the mu opioid receptor. The ability of inflammatory processes to alter both endogenous opioids and morphine analgesia at the spinal level illustrates the considerable degree of plasticity observed in opioid function.
Stanfa
L
L
Department of Pharmacology, University College London, UK.
Dickenson
A
A
D000698:Analgesia; D000818:Animals; D002351:Carrageenan / Q000633:toxicity; D002766:Cholecystokinin / Q000378:metabolism; D004195:Disease Models, Animal; D007249:Inflammation / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology; D007278:Injections, Spinal; D009294:Narcotics / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D018847:Opioid Peptides / Q000502:physiology*; D010146:Pain / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D018341:Receptors, Adrenergic, alpha-2 / Q000187:drug effects / Q000378:metabolism; D011957:Receptors, Opioid / Q000187:drug effects / Q000378:metabolism / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects / Q000378:metabolism*; D009435:Synaptic Transmission / Q000187:drug effects
D009294:Narcotics; D018847:Opioid Peptides; D018341:Receptors, Adrenergic, alpha-2; D011957:Receptors, Opioid; D002351:Carrageenan; D002766:Cholecystokinin