Effect of cadmium in the zinc deficient rat.
Three-w-old male Sprague-Dawley rats were given a zinc (Zn)-deficient (0 ppm Zn) or a Zn-adequate diet (30 ppm Zn) supplemented with 0, 0.5 or 100 ppm cadmium (Cd) for up to 5 mo. The proximal convoluted tubules of the kidneys had degenerative changes in the rats fed the Zn-deficient diet containing 100 ppm Cd [Zn 0, Cd 100], but there were no lesions in other groups. Electron microscopy showed cytoplasmic vacuolation of the proximal tubules, mitochondrial swelling and coagulative necrosis in Zn 0:Cd 100 rats. The present study revealed diminished bone growth and cortical thinning of the femur, but there was no osteomalacia seen in Itai-Itai disease patients. The results indicate that Zn deficiency may enhance the renal toxicity of Cd, but that dietary Cd did not cause osteomalacia even under severe Zn-deficient conditions.
Tanaka
M
M
Department of Veterinary Pathology, School of Veterinary Medicine, Azabu University, Kanagawa, Japan.
Yanagi
M
M
Shirota
K
K
Une
Y
Y
Nomura
Y
Y
Masaoka
T
T
Akahori
F
F
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002104:Cadmium / Q000008:administration & dosage / Q000633:toxicity*; D002105:Cadmium Poisoning / Q000150:complications / Q000000981:diagnostic imaging / Q000503:physiopathology; D003593:Cytoplasm / Q000473:pathology; D004195:Disease Models, Animal; D005269:Femur / Q000187:drug effects* / Q000473:pathology; D007687:Kidney Tubules, Proximal / Q000187:drug effects* / Q000473:pathology / Q000648:ultrastructure; D008141:Lordosis / Q000139:chemically induced / Q000000981:diagnostic imaging; D008297:Male; D008854:Microscopy, Electron; D008933:Mitochondrial Swelling / Q000187:drug effects; D009336:Necrosis / Q000139:chemically induced; D010018:Osteomalacia / Q000139:chemically induced / Q000503:physiopathology; D011859:Radiography; D051381:Rats; D017207:Rats, Sprague-Dawley; D013047:Specific Pathogen-Free Organisms; D013131:Spine / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000473:pathology; D015032:Zinc / Q000172:deficiency*
D002104:Cadmium; D015032:Zinc