The relation zinc-lipidic peroxidation in experimental diabetes mellitus.
The authors investigated the influence of Zn upon glycemy and certain REDOX parametres within the hepatic tissue. The experiment was performed on young Wistar rats with AD, to which Zn sulfate was administered. The values of the antioxidating enzymes: cathalasis and peroxidase decrease in the diabetes' hepatic tissue. The therapy with Zn remakes their activities and increases glutathione synthesis. The Zn protecting effect in lipidic peroxidating process also acts upon hepatocyte membrane, fact illustrated by the decrease of LDH in the plasma of the animals treated with Zn.
Bădescu
M
M
Department of Pathophysiology, University of Medicine and Pharmacy, Iaşi.
Păduraru
I
I
Colev
V
V
Saramet
A
A
Bohotin
C
C
Bădescu
L
L
D000818:Animals; D002374:Catalase / Q000378:metabolism; D003921:Diabetes Mellitus, Experimental / Q000378:metabolism*; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008054:Lipid Peroxides / Q000378:metabolism*; D008297:Male; D009195:Peroxidase / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D015032:Zinc / Q000494:pharmacology*
D008054:Lipid Peroxides; D007770:L-Lactate Dehydrogenase; D002374:Catalase; D009195:Peroxidase; D015032:Zinc