Anti-lymphocyte globulin therapy in aplastic anaemia--a university hospital experience.
Antilymphocyte globulin (ALG) was given every other day for 5 doses with platelet transfusions immediately following ALG administration in 6 patients with aplastic anaemia. Four patients responded and 3 durable remissions were achieved. One patient relapsed and further treatment with anti-thymocyte globulin and cyclosporin also failed. One patient died of Flavobacterium septicaemia 6 days after completion of ALG. Our data suggests that using an alternate day regimen, a response rate similar to a daily regimen can be obtained.
Leong
K W
KW
Department of Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur.
Teh
A
A
Bosco
J J
JJ
Jayaranee
S
S
Sadat
U
U
D000293:Adolescent; D000328:Adult; D000741:Anemia, Aplastic / Q000628:therapy*; D000961:Antilymphocyte Serum / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006785:Hospitals, University; D006801:Humans; D008297:Male; D017713:Platelet Transfusion; D016896:Treatment Outcome
D000961:Antilymphocyte Serum