Rebamipide, novel prostaglandin-inducer accelerates healing and reduces relapse of acetic acid-induced rat gastric ulcer. Comparison with cimetidine.
This study was done to elucidate whether rebamipide during the initial period of acetic acid-induced gastric ulcer affected healing and future ulcer relapse. The cumulative healing rate was higher in rats given rebamipide alone or those given rebamipide and cimetidine during and after administration, but not in rats given cimetidine alone, compared to control rats. Cumulative relapse rate was significantly lower in rats initially given rebamipide alone or those given rebamipide and cimetidine than in rats initially given cimetidine alone. These results suggest that rebamipide is beneficial for obtaining a better quality of ulcer healing and reduction of future ulcer relapse.
Arakawa
T
T
Third Department of Internal Medicine, Osaka City University Medical School, Japan.
Watanabe
T
T
Fukuda
T
T
Yamasaki
K
K
Kobayashi
K
K
D000085:Acetates; D019342:Acetic Acid; D000409:Alanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000818:Animals; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002927:Cimetidine / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D008297:Male; D011453:Prostaglandins / Q000096:biosynthesis; D015363:Quinolones / Q000008:administration & dosage / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012008:Recurrence; D013276:Stomach Ulcer / Q000139:chemically induced / Q000188:drug therapy* / Q000517:prevention & control; D014945:Wound Healing / Q000187:drug effects
D000085:Acetates; D000897:Anti-Ulcer Agents; D011453:Prostaglandins; D015363:Quinolones; D002927:Cimetidine; C052785:rebamipide; D000409:Alanine; D019342:Acetic Acid