Inter-subject variability in the metabolism of aluminium following intravenous injection as citrate.
1. Six healthy male volunteers received intravenous injections of 26Al as citrate. Accelerator mass spectrometry and gamma-ray spectrometry were used to determine levels of the tracer in blood and excreta at times up to 5-6 d. 2. There was a rapid clearance from blood (mean 2% of injection remaining after 1 d) and major loss in urine (59% up to 1 d), but 27 +/- 7 (s.d.)% was retained in the body at 5 d. Faecal excretion was negligible (1% up to 5 d). 3. The mean results accord with the early metabolic pattern in the single subject of a previous, more extensive study, who had retained 4% of the injection after 3 y. Together, the two studies point to the likelihood of large inter-subject differences in the long-term accumulation of dietary aluminium by populations receiving a given level of daily intake.
Talbot
R J
RJ
AEA Technology, Didcot, Oxon, UK.
Newton
D
D
Priest
N D
ND
Austin
J G
JG
Day
J P
JP
D000328:Adult; D000535:Aluminum / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D002951:Citrates / Q000097:blood / Q000493:pharmacokinetics* / Q000652:urine; D019343:Citric Acid; D005243:Feces / Q000737:chemistry; D006801:Humans; D007275:Injections, Intravenous; D008297:Male
D002951:Citrates; D019343:Citric Acid; D000535:Aluminum