title: Determinants of cerebral oxygenation during cardiac surgery.
abstract: BACKGROUND
  Neuropsychological deficits after cardiac surgery are attributed to the side effects of cardiopulmonary bypass (CPB). To protect the brain from ischemic damage, the influences of temperature, blood pressure, blood gases, acid-base status, and hemodilution on cerebral oxygenation have to be elucidated and quantified.
  
  
  METHODS
  Forty-one consecutive patients were investigated during cardiac surgery while on CPB. Operative management included moderate hypothermia of 26 degrees C and the alpha-stat pH management. With near-infrared spectrophotometry, changes in oxygenated hemoglobin (HbO2, representing oxygen delivery) and oxidized cytochrome a,a3 (CtO2, cellular oxygenation) in brain tissue were obtained noninvasively. In addition, venous saturation of the brain was measured via a catheter in the jugular bulb (SBJO2). The influence of operative management parameters on cerebral oxygenation was calculated by univariate and multiple regression analyses.
  
  
  RESULTS
  Before and after CPB there was no significant multivariate determinant of cerebral oxygenation. During CPB, HbO2 depended solely on PCO2 (P < .01; r = .89). CtO2 was determined by pH (P < .01), esophageal temperature (P < .01), PCO2 (P < .01), and Hb (P < .01). These parameters explained nearly all changes of the cytochrome measurements during CPB (r = .99). Arterial PCO2 (P < .01) and pH (P < .01) influenced brain venous oxygen saturation (SBJO2; r = .98).
  
  
  CONCLUSIONS
  Cerebral oxygenation is autoregulated during cardiac surgery before and after CPB. During CPB, Hb, temperature, pH, and PCO2 determined at least 85% of all changes in cerebral oxygenation. The main causes of impaired cerebral oxygenation are the decrease in Hb with hemodilution, vasoconstriction due to hypocapnia, and the leftward shift of the Hb binding curve in alkalosis and hypothermia.
authors.affiliation: Department of Cardiac Surgery, Klinikum Grosshadern, University of Munich, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Nollert
authors.forename: P
authors.initials: P
authors.lastname: Möhnle
authors.forename: P
authors.initials: P
authors.lastname: Tassani-Prell
authors.forename: B
authors.initials: B
authors.lastname: Reichart
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000098:blood supply / Q000378:metabolism*; D006348:Cardiac Surgical Procedures / Q000379:methods; D002315:Cardiopulmonary Bypass; D016893:Carotid Stenosis / Q000378:metabolism; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D010100:Oxygen / Q000097:blood; D010101:Oxygen Consumption; D011184:Postoperative Period; D013055:Spectrophotometry, Infrared
chemical_list: D010100:Oxygen