title: [Glutathione in the treatment of chronic fatty liver diseases].
abstract: In chronic steatosic liver disease, alcohol or non-alcohol related or HBV, HCV, HDV associated, a reduction in hepatic glutathione and, consequently, in the detoxifying effects of hepatocytes is observed. Intravenous administration of high dose glutathione in patients with chronic steatosic liver disease has shown that glutathione significantly improves the rate of some hepatic tests (bilirubin, GOT, GPT, GT) even several months after treatment interruption. Further confirmation of the efficacy of GSH treatment is provided by the reduction of malondialdehyde, a marker of hepatic cell damage. The optimal results obtained in patients receiving 1800 mg/die/i.v. advocate the use of this high dosage.
authors.affiliation: Istituto Policattedra, Università, Bari.
authors.forename: P
authors.initials: P
authors.lastname: Dentico
authors.forename: A
authors.initials: A
authors.lastname: Volpe
authors.forename: R
authors.initials: R
authors.lastname: Buongiorno
authors.forename: I
authors.initials: I
authors.lastname: Grattagliano
authors.forename: E
authors.initials: E
authors.lastname: Altomare
authors.forename: G
authors.initials: G
authors.lastname: Tantimonaco
authors.forename: G
authors.initials: G
authors.lastname: Scotto
authors.forename: R
authors.initials: R
authors.lastname: Sacco
authors.forename: O
authors.initials: O
authors.lastname: Schiraldi
mesh_terms: D000328:Adult; D000368:Aged; D005234:Fatty Liver / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D005235:Fatty Liver, Alcoholic / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D005978:Glutathione / Q000008:administration & dosage / Q000627:therapeutic use*; D006509:Hepatitis B / Q000150:complications; D006526:Hepatitis C / Q000150:complications; D003699:Hepatitis D / Q000150:complications; D006801:Humans; D008111:Liver Function Tests; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged
chemical_list: D008315:Malondialdehyde; D005978:Glutathione
vernacular_title: Il glutatione nella terapia delle epatopatie croniche steatosiche.