The role of dietary factors and chemoprevention in gastrointestinal malignancy.
Environmental factors, particularly pertaining to the diet, are of importance in the pathogenesis of gastrointestinal neoplasia. Increasingly sophisticated studies have begun to elucidate some of the mechanisms responsible for both the deleterious and protective effects of compounds ingested or smoked (such as tobacco). The new and developing field of chemoprevention holds great promise for the possibility of averting neoplasia by interfering with the metabolism of carcinogens, reducing their binding to the target cell, or even by suppressing the initiated cell.
Levin
B
B
University of Texas MD Anderson Cancer Center, Houston, USA.
D000975:Antioxidants / Q000627:therapeutic use; D002118:Calcium / Q000627:therapeutic use; D015179:Colorectal Neoplasms / Q000188:drug therapy / Q000517:prevention & control; D004043:Dietary Fiber; D004938:Esophageal Neoplasms / Q000517:prevention & control; D005247:Feeding Behavior; D005260:Female; D005419:Flavonoids / Q000627:therapeutic use; D005770:Gastrointestinal Neoplasms / Q000178:diet therapy / Q000209:etiology / Q000517:prevention & control*; D006801:Humans; D008297:Male; D013274:Stomach Neoplasms / Q000453:epidemiology / Q000209:etiology / Q000401:mortality; D013467:Sulindac / Q000627:therapeutic use; D014815:Vitamins / Q000627:therapeutic use
D000975:Antioxidants; D004043:Dietary Fiber; D005419:Flavonoids; D014815:Vitamins; D013467:Sulindac; D002118:Calcium