Chromosome assignments of genes for human Na(+)-dependent phosphate co-transporters NaPi-3 and NPT-1.
Chromosome assignments for the genes encoding human renal high affinity Na/phosphate co-transporters NaPi-3 and NPT-1 were derived by analyzing somatic cell hybrid DNAs. Polymerase chain reaction (PCR), using primers specific for two human Na/Pi co-transporters demonstrated that the genes for NaPi-3 was assigned to human chromosome 5 while that for NPT-1 was assigned to human chromosome 6. Renal phosphate transporter genes may be candidates for causing hereditary hypophosphatemia with hypercalciuria in humans.
Miyamoto
K
K
Department of Clinical Nutrition, School of Medicine, University of Tokushima, Japan.
Tatsumi
S
S
Yamamoto
H
H
Katai
K
K
Taketani
Y
Y
Morita
K
K
Takeda
E
E
D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D002896:Chromosomes, Human, Pair 6; D006801:Humans; D007015:Hypophosphatemia, Familial / Q000235:genetics; D007668:Kidney / Q000378:metabolism*; D008969:Molecular Sequence Data; D050608:Sodium-Phosphate Cotransporter Proteins; D050609:Sodium-Phosphate Cotransporter Proteins, Type I; D027981:Symporters
D002352:Carrier Proteins; C493546:SLC17A1 protein, human; D050608:Sodium-Phosphate Cotransporter Proteins; D050609:Sodium-Phosphate Cotransporter Proteins, Type I; D027981:Symporters