title: A baboon (Papio hamadryas) model of insulin-dependent diabetes.
abstract: Over a period of four years, streptozocin has been used to induce diabetes in 10 baboons, all of whom are insulin dependent. We describe our experience with their husbandry, induction of diabetes, insulin therapy, metabolic control and growth rate. Streptozocin dosage of 60 mg/kg readily induces hyperglycemia with minimal hepatic or renal toxicity. Using a once daily injection of mixed short and intermediate acting insulins at a dosage of 2-4 U/kg, it is possible to maintain a degree of metabolic control similar to that attained in patients.
authors.affiliation: Department of Endocrinology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
authors.forename: S
authors.initials: S
authors.lastname: Heffernan
authors.forename: A
authors.initials: A
authors.lastname: Phippard
authors.forename: A
authors.initials: A
authors.lastname: Sinclair
authors.forename: S
authors.initials: S
authors.lastname: McLennan
authors.forename: A
authors.initials: A
authors.lastname: Hennessy
authors.forename: A
authors.initials: A
authors.lastname: Gillin
authors.forename: J
authors.initials: J
authors.lastname: Horvath
authors.forename: D
authors.initials: D
authors.lastname: Tiller
authors.forename: D
authors.initials: D
authors.lastname: Yue
authors.forename: J
authors.initials: J
authors.lastname: Turtle
mesh_terms: D000375:Aging; D000822:Animal Husbandry; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism*; D003404:Creatinine / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology*; D006442:Glycated Hemoglobin / Q000032:analysis; D007328:Insulin / Q000627:therapeutic use*; D010215:Papio / Q000254:growth & development; D012016:Reference Values; D013311:Streptozocin / Q000633:toxicity; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D003404:Creatinine; D006442:Glycated Hemoglobin; D007328:Insulin; D013311:Streptozocin