New aspects of the role of histamine in cardiovascular function: identification, characterization, and potential pathophysiological importance of H3 receptors.
As a result of intensive research during several decades, the distribution, function, and pathophysiological role of cardiovascular H1 and H2 receptors are well known, whereas reports on the occurrence and function of H3 receptors in blood vessels and the heart have not become available before the last 7 years (i.e., 4 years after the first description of these receptors in the central nervous system in 1983). The development of selective and potent H3 receptor agonists and antagonists was a prerequisite for convenient investigations of cardiovascular H3 receptors, which like H1 and H2 receptors are G-protein coupled but unlike them have not yet been cloned. Both in blood vessels and the heart, H3 receptors are located on noradrenergic nerve endings and upon stimulation mediate an inhibition of noradrenaline release. Whereas it remains to be clarified under which conditions the vascular H3 receptors may be stimulated by endogenous histamine, those in the heart become activated in the early phases of myocardial ischemia characterized by an increased histamine spillover. The H3 receptors in the central nervous system also appear to be of importance for the control of vascular function. Inhibitory presynaptic H3 receptors occur on trigeminal sensory C fibres supplying blood vessels in the dura mater. Release of neuropeptides from these fibres induces a neurogenic inflammation, which has been suggested to be involved in the pathogenesis of migraine. An interaction, involving presynaptic H3 receptors, between sensory C fibres and mast cells in close apposition to these fibres plays a role in the control of histamine synthesis in the dura mater.(ABSTRACT TRUNCATED AT 250 WORDS)
Göthert
M
M
Institute of Pharmacology and Toxicology, University of Bonn, Germany.
Garbarg
M
M
Hey
J A
JA
Schlicker
E
E
Schwartz
J C
JC
Levi
R
R
D000818:Animals; D001808:Blood Vessels / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D006321:Heart / Q000502:physiology; D006632:Histamine / Q000502:physiology*; D008881:Migraine Disorders / Q000503:physiopathology; D009638:Norepinephrine / Q000502:physiology; D018100:Receptors, Histamine H3 / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology; D013997:Time Factors
D018100:Receptors, Histamine H3; D006632:Histamine; D009638:Norepinephrine