[Synthesis and pharmacological study of adamantyl benzene propanamines and propenamines].
gamma-(1-Adamantyl)benzenepropanamines and gamma-(1-adamantyl)benzene-beta-propenamines were synthesized and their pharmacological action was studied on mice. Behavioral effects obtained with these compounds and specially the study of convulsions, induced by these derivatives, could show a rise of the gamma-(1-adamantyl)benzenepropanamine's antinicotinic component, which is characteristic of all the adamantanamines. On the contrary gamma-(1-adamantyl)benzene-beta-propenamine's molecular torsion, induced by the double bond, coudl confer to these derivatives agonistic properties on the central nicotinic receptor sites.
Pouli
N
N
Laboratoire de Chimie Pharmaceutique, Université d'Athènes, Grèce.
Fytas
G
G
Foscolos
G B
GB
Kolocouris
N
N
Marakos
P
P
Vamvakides
A
A
D000218:Adamantane / Q000031:analogs & derivatives / Q000138:chemical synthesis* / Q000494:pharmacology*; D000818:Animals; D055598:Chemical Phenomena; D002621:Chemistry; D018680:Cholinergic Antagonists / Q000032:analysis; D003292:Convulsants / Q000138:chemical synthesis* / Q000494:pharmacology*; D008297:Male; D051379:Mice; D011437:Propylamines / Q000138:chemical synthesis* / Q000494:pharmacology*; D011978:Receptors, Nicotinic / Q000378:metabolism
D018680:Cholinergic Antagonists; D003292:Convulsants; D011437:Propylamines; D011978:Receptors, Nicotinic; D000218:Adamantane
Synthèse et étude pharmacologique des adamantylbenzènepropanamines et propénamines.