Effects of efonidipine hydrochloride (NZ-105), a calcium antagonist, on renal function in conscious spontaneously hypertensive rats.
1. We investigated the effects of short- and long-term administration of efonidipine hydrochloride (NZ-105), 1,4-dihydropyridine derivative, in conscious spontaneously hypertensive rats (SHR). 2. Oral administration of NZ-105 for 12 weeks caused diuretic and natriuretic effects, which were not attenuated during the experimental period. 3. In the short-term experiment for investigating the mechanism of the diuretic effect, intravenous injection of NZ-105 (0.03 mg/kg of body weight) significantly increased the urine volume (UV), renal plasma flow (RPF) and glomerular filtration rate (GFR). The increment rate of UV and RPF was 105.4 +/- 17.8% and 111.7 +/- 72.8%, respectively, which were larger than the increment rate of GFR (38.5 +/- 14.0%). 4. The diuretic or natriuretic effect of NZ-105 was suggested to be due to both the inhibition of sodium reabsorption and, at least in part, the increase of GFR.
Yotsumoto
T
T
Shiroaka Research Station of Biological Science, Nissan Chemical Industries Ltd., Saitama, Japan.
Masuda
Y
Y
Shudo
C
C
Sugita
H
H
Yamashita
T
T
Tanaka
S
S
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D004095:Dihydropyridines / Q000494:pharmacology*; D004232:Diuretics / Q000494:pharmacology*; D004334:Drug Administration Schedule; D006977:Hypertension, Renal / Q000188:drug therapy* / Q000503:physiopathology / Q000652:urine; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D009596:Nitrophenols; D009943:Organophosphorus Compounds / Q000494:pharmacology*; D011188:Potassium / Q000652:urine; D051381:Rats; D011918:Rats, Inbred SHR; D012079:Renal Circulation / Q000187:drug effects; D012964:Sodium / Q000652:urine
D002121:Calcium Channel Blockers; D004095:Dihydropyridines; D004232:Diuretics; D009596:Nitrophenols; D009943:Organophosphorus Compounds; C066425:efonidipine; D012964:Sodium; D011188:Potassium