Mycalolides D and E, new cytotoxic macrolides from a collection of the stony coral Tubastrea faulkneri.
Fractionation of a cytotoxic extract of the stony coral Tubastrea faulkneri yielded a series of cytotoxic polyoxazole macrolides and several noncytotoxic indole derivatives. Two new macrolides, mycalolides D [1] and E [2], were isolated and identified, in addition to the known compound mycalolide C [3]. The macrolide structures were elucidated by detailed analysis of their spectroscopic data and by comparison with related compounds.
Rashid
M A
MA
Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
Gustafson
K R
KR
Cardellina
J H
JH
Boyd
M R
MR
D000818:Animals; D000970:Antineoplastic Agents / Q000302:isolation & purification* / Q000494:pharmacology*; D003063:Cnidaria / Q000737:chemistry*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008387:Marine Toxins; D010080:Oxazoles / Q000302:isolation & purification* / Q000494:pharmacology; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D008387:Marine Toxins; D010080:Oxazoles; C095788:mycalolide D; C095789:mycalolide E