title: [Echocardiography and MIBI-SPECT scintigraphy during dobutamine infusion in the diagnosis of coronary disease].
abstract: OBJECTIVE
  Dobutamine, an adrenergic agonist, has been combined with echocardiography and scintigraphy with MIBI-SPECT to detect coronary artery disease. Our purpose has been to compare echocardiography and MIBI-SPECT scintigraphy during dobutamine infusion for diagnosing coronary artery disease.
  
  
  METHODS
  Both tests and coronary angiography have been performed on 72 consecutive patients with chest pain and no previous history of coronary artery disease. Dobutamine had administered up to 40 micrograms/kg/min. Atropine was given when necessary. MIBI was injected at peak stress. Echocardiographic continuous monitoring and SPECT images were carried out. Positivity was defined as: 1) echocardiographic: wall motion abnormalities of new onset, and 2) scintigraphic: dobutamine-induced perfusion abnormalities.
  
  
  RESULTS
  Coronary artery disease was demonstrated in 49 patients. Echocardiography was positive in 37 of them (sensitivity of 75%) and MIBI-SPECT in 43 (sensitivity of 88%; p = NS). Specificity was higher with echocardiography (22/23, 96%) than with scintigraphy (16/23, 69%, p = 0.02). Accuracy was 82% for both tests. More patients with multivessel disease were detected by scintigraphy (61% versus 35%; p = 0.09). Agreement between tests was as follows: 1) results: 77% (kappa = 0.53); 2) segments: 86% (kappa = 0.65), and 3) artery diseased: 90% (kappa = 0.84).
  
  
  CONCLUSIONS
  Echocardiography and MIBI-SPECT in combination with doubtamine are useful techniques to detect coronary artery disease. Diagnostic accuracy is similar with both tests.
authors.affiliation: Servico de Cardiología, Hospital Universitario, Valladolid.
authors.forename: J A
authors.initials: JA
authors.lastname: San Román
authors.forename: M J
authors.initials: MJ
authors.lastname: Rollán
authors.forename: I
authors.initials: I
authors.lastname: Vilacosta
authors.forename: J A
authors.initials: JA
authors.lastname: Castillo
authors.forename: E
authors.initials: E
authors.lastname: Meroño
authors.forename: M
authors.initials: M
authors.lastname: Hernández
authors.forename: L
authors.initials: L
authors.lastname: Sánchez-Harguindey
authors.forename: F
authors.initials: F
authors.lastname: Fernández Avilés
mesh_terms: D000318:Adrenergic beta-Agonists; D002316:Cardiotonic Agents; D003287:Contrast Media; D017023:Coronary Angiography; D003327:Coronary Disease / Q000175:diagnosis* / Q000000981:diagnostic imaging; D003627:Data Interpretation, Statistical; D004280:Dobutamine; D004452:Echocardiography; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000318:Adrenergic beta-Agonists; D002316:Cardiotonic Agents; D003287:Contrast Media; D004280:Dobutamine; D017256:Technetium Tc 99m Sestamibi
vernacular_title: Ecocardiografía y gammagrafía con MIBI-SPECT durante la infusión de dobutamina en el diagnóstico de la enfermedad coronaria.