title: Acute myeloid leukemia: lack of predictive value of sequential quantitative MR imaging during treatment.
abstract: OBJECTIVE
  To assess the use of magnetic resonance (MR) imaging in monitoring treatment response in patients with acute myeloid leukemia (AML).
  
  
  METHODS
  Bulk T1 and T2 were determined with at least four MR imaging examinations (strictly timed) during the first 6 weeks of treatment in 29 patients with AML (age range, 16-75 years; 15 female, and 14 male). Bulk T1 and T2 in responder (n = 22) and nonresponder (n = 7) patients were compared.
  
  
  RESULTS
  Relative to pretreatment bulk T1 values, bulk T1 had increased a mean of 11% at week 1 and had decreased a mean of 7% and 39% at weeks 2 and 6, respectively. Values in nonresponder patients were not statistically significantly different (+11%, -14%, -38%).
  
  
  CONCLUSIONS
  MR imaging of lumbar bone marrow in patients with AML demonstrated statistically significant changes in bulk T1 during treatment that correlated with changes in cellularity. However, neither the early increase in bulk T1 nor the rate or magnitude of the subsequent decrease in bulk T1 were indicative of a positive response to treatment.
authors.affiliation: Department of Radiology and Medical Imaging, St Luc University Hospital UCL, Brussels, Belgium.
authors.forename: B C
authors.initials: BC
authors.lastname: Vande Berg
authors.forename: P J
authors.initials: PJ
authors.lastname: Schmitz
authors.forename: J M
authors.initials: JM
authors.lastname: Scheiff
authors.forename: B J
authors.initials: BJ
authors.lastname: Filleul
authors.forename: J L
authors.initials: JL
authors.lastname: Michaux
authors.forename: A
authors.initials: A
authors.lastname: Ferrant
authors.forename: J
authors.initials: J
authors.lastname: Jamart
authors.forename: J
authors.initials: J
authors.lastname: Malghem
authors.forename: B E
authors.initials: BE
authors.lastname: Maldague
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000175:diagnosis* / Q000628:therapy; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests