Clinical, neurophysiologic, and neuropathological features of an infant with brain damage of total asphyxia type (Myers).
An infant who demonstrated clinical features compatible with total asphyxia is reported. Immediately after birth, the patient manifested severe hypotonia and total absence of cranial nerve functions. Magnetic resonance imaging revealed abnormal intensity of the thalamus and putamen, and atrophy of the brainstem. Late components of brainstem auditory evoked potential were absent, but electroencephalography was normal. Postmortem autopsy revealed destructive lesions of the brainstem tegmentum, thalamus, basal ganglia, and spinal cord, but preserved cerebral cortex; findings consistent with those of total asphyxia as reported by Myers, and attributable to prenatal insult.
Natsume
J
J
Department of Pediatrics, Nagoya University School of Medicine, Anjo Kosei Hospital, Japan.
Watanabe
K
K
Kuno
K
K
Hayakawa
F
F
Hashizume
Y
Y
D001238:Asphyxia Neonatorum / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D001284:Atrophy; D001479:Basal Ganglia / Q000473:pathology / Q000503:physiopathology; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D001933:Brain Stem / Q000473:pathology / Q000503:physiopathology; D004569:Electroencephalography; D016057:Evoked Potentials, Auditory, Brain Stem / Q000502:physiology; D017809:Fatal Outcome; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008636:Mesencephalon / Q000473:pathology / Q000503:physiopathology; D011699:Putamen / Q000473:pathology / Q000503:physiopathology; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology; D013788:Thalamus / Q000473:pathology / Q000503:physiopathology