Nifedipine versus fentanyl to prevent the pressor response to tracheal intubation.
Thirty six patients ASA 1 or 2, undergoing surgery that required tracheal intubation, were allocated randomly into three groups of twelve each. Before induction of anesthesia, they received either saline, 10 mg, nifedipine sublingual, or fentanyl 1.5 micrograms.kg-1 IV. Heart rate (HR), systolic blood pressure (SAP), diastolic blood pressure (DBP), and mean blood pressure (MAP), were recorded automatically every minute for 5 minutes before induction of anesthesia, and for 5 minutes after intubation. Nifedipine was better than fentanyl in blocking the pressor response. The fentanyl dose was too small to abolish this response completely. The increase in HR and blood pressure were most evident in the control group, followed by fentanyl, and the least increase was seen with nifedipine.
Abdel-Razek
A
A
Al-Huwaylat Hospital, Jubail Industrial City, Saudi Arabia.
el-Attar
A M
AM
D000286:Administration, Sublingual; D000293:Adolescent; D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000627:therapeutic use*; D017704:Baroreflex / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000008:administration & dosage / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D005283:Fentanyl / Q000008:administration & dosage / Q000627:therapeutic use*; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D007442:Intubation, Intratracheal / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000008:administration & dosage / Q000627:therapeutic use*; D011229:Preanesthetic Medication
D018686:Anesthetics, Intravenous; D002121:Calcium Channel Blockers; D009543:Nifedipine; D005283:Fentanyl