title: Expression of fibrinogen receptors and GPIIb molecules on uraemic platelets: effect of recombinant human erythropoietin therapy.
abstract: In 14 chronic uraemic patients on regular haemodialysis treatment mean numbers of fibrinogen (Fg) receptors and glycoprotein IIb (GPIIb) molecules on one blood platelet were 8370 +/- 1282 and 15,694 +/- 2102 respectively, and they were significantly lowered in comparison with those found in 14 healthy persons (37,826 +/- 966 and 57,994 +/- 6824 respectively). A high positive correlation was found between numbers of GPIIb molecules and those of Fg receptors both in chronic uraemic patients and healthy subjects. Four-month treatment of haemodialysis patients with recombinant human erythropoietin (rHuEpo) induced significant rises in haematocrit from 22.3 +/- 1.2 to 31.2 +/- 1.7%, blood platelet count from 164,000 +/- 27,000/microliters to 206,000 +/- 16,000/microliters and mean platelet volume from 7.08 +/- 0.29 fl to 8.26 +/- 0.22 fl. However, in haemodialysis patients numbers of the investigated surface platelet receptors, measured at 8 and 16 week of rHuEpo treatment, remained unchanged.
authors.affiliation: Department of Biophysics, Medical School, Lódź, Poland.
authors.forename: J
authors.initials: J
authors.lastname: Krzesłowska
authors.forename: J
authors.initials: J
authors.lastname: Rysz
authors.forename: C S
authors.initials: CS
authors.lastname: Cierniewski
authors.forename: M
authors.initials: M
authors.lastname: Luciak
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D000328:Adult; D001760:Bleeding Time; D001792:Blood Platelets / Q000378:metabolism*; D004921:Erythropoietin / Q000627:therapeutic use*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins; D006801:Humans; D007279:Injections, Subcutaneous; D039421:Integrin alpha2; D008297:Male; D008562:Membrane Glycoproteins / Q000097:blood* / Q000187:drug effects; D008875:Middle Aged; D015539:Platelet Activation; D010976:Platelet Count; D019039:Platelet Glycoprotein GPIIb-IIIa Complex / Q000187:drug effects / Q000378:metabolism*; D006435:Renal Dialysis; D014511:Uremia / Q000097:blood* / Q000628:therapy
chemical_list: D006454:Hemoglobins; C056564:ITGA2B protein, human; D039421:Integrin alpha2; D008562:Membrane Glycoproteins; D019039:Platelet Glycoprotein GPIIb-IIIa Complex; D004921:Erythropoietin; D000244:Adenosine Diphosphate