The pros and cons of drug 'trafficking'.
Internalization of targeted therapeutics is often needed for efficacy, but also alters drug penetration of a tissue. A new model explores the trade-offs of intracellular drug trafficking.
Stokes
C L
CL
Department of Chemical Engineering, University of Houston, Texas 77204, USA.
D000818:Animals; D001692:Biological Transport; D003198:Computer Simulation; D004058:Diffusion; D004337:Drug Carriers; D015195:Drug Design; D006801:Humans; D008954:Models, Biological; D010599:Pharmacokinetics; D011955:Receptors, Drug / Q000378:metabolism; D014018:Tissue Distribution
D004337:Drug Carriers; D011955:Receptors, Drug