Use of ambroxol and bromhexine as mucolytics for enhanced diffusion of furaltadone into tracheobronchial secretions in broilers.
1. Ambroxol and bromhexine were evaluated as mucolytics and to enhance the passage of furaltadone into tracheobronchial secretions (TBS) in chronic complicated respiratory disease-affected broilers. 2. Viscosity of TBS was noticeably increased in the ambroxol-treated birds and only slightly increased in the bromhexine groups; however, the physical (nature) of TBS was superior in the ambroxol-treated broilers. 3. There was a clear increase in the passage of furaltadone into tracheobronchial secretions only in the ambroxol-treated birds. 4. Everyday use of ambroxol in broilers is discussed.
Sumano
H
H
Department of Pharmacology, Faculty of Veterinary Medicine and Husbandry, Universidad Nacional Autónoma de México, (UNAM) Mexico City.
Gracia
I
I
Capistrán
A
A
Meade
G
G
Rivero
A
A
Ruiz-Ramírez
L
L
D000551:Ambroxol / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001964:Bromhexine / Q000494:pharmacology*; D001980:Bronchi / Q000378:metabolism; D002645:Chickens; D004347:Drug Interactions; D005100:Expectorants / Q000494:pharmacology*; D009581:Nitrofurans / Q000493:pharmacokinetics*; D023303:Oxazolidinones; D012137:Respiratory System / Q000187:drug effects / Q000378:metabolism*; D014132:Trachea / Q000378:metabolism
D005100:Expectorants; D009581:Nitrofurans; D023303:Oxazolidinones; D000551:Ambroxol; C007795:furaltadon; D001964:Bromhexine