Parathyroid hormone-related peptide expression in endocrine tumors.
Parathyroid hormone-related peptide (PTHrP) expression is associated with the histological type in pituitary tumor, but not in thyroid carcinoma. However invasive and metastatic tumors showed intense PTHrP staining in both pituitary and thyroid tumors. Analysis of the established metastatic rat pituitary tumor cell line showed that PTHrP plays a crucial role in in vivo cell proliferation closely related to worsening of malignant transformation and neovascularization in a paracrine fashion.
Nagataki
S
S
First Department of Internal Medicine, Nagasaki University School of Medicne, Japan.
Nakashima
M
M
Akino
K
K
Ohtsuru
A
A
Namba
H
H
Kiriyama
T
T
Ito
M
M
Sekine
I
I
Yamashita
S
S
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D004701:Endocrine Gland Neoplasms / Q000378:metabolism*; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D010281:Parathyroid Hormone / Q000096:biosynthesis*; D044162:Parathyroid Hormone-Related Protein; D010911:Pituitary Neoplasms / Q000378:metabolism; D014176:Protein Biosynthesis; D013964:Thyroid Neoplasms / Q000378:metabolism
D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein