title: Increased incidence of spina bifida occulta in fluorosis prone areas.
abstract: Spina bifida, a congenital deformity of the posterior wall of vertebrae of the spine, is a midline defect of skin, vertebral arches and neural tube, usually in the lumbosacral region. Its incidence is reported to be 0.2 to 0.4 per 1000 live births. Various hypotheses have been put forward as etiological factors for spina bifida including consumption of potato affected by blight and hardness of drinking water but these have not been proven. Two groups of 50 randomly chosen children were established. The study group consisted of children aged 5 to 12 years, weighing 15 to 30 kg, consuming fluoride rich drinking water (4.5 and 8.5 ppm fluoride; WHO permissible limit is 1.5 ppm fluoride), and manifesting either clinical, dental and/or skeletal fluorosis. The control group consisted of age and weight-matched children, consuming less than or equal to 1.5 ppm fluoride in drinking water and not showing any evidence of fluoride toxicity. These children were evaluated for antenatal history, general clinical examination (especially for dimples, tufts of hair, haemangioma on skin throughout the length of spine), other congenital abnormalities, evidence of fluoride toxicity, biochemical estimation for fluoride levels in blood and serum and by skiagrams of the spine to examine for the presence of spina bifida occulta. A total of 22 (44%) of the 50 children in group A, the study group, and 6 (12%) of the 50 children in group B, the control group, revealed spina bifida occulta in the lumbosacral region.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Physiology, SMS Medical College, Jaipur, India.
authors.forename: S K
authors.initials: SK
authors.lastname: Gupta
authors.forename: R C
authors.initials: RC
authors.lastname: Gupta
authors.forename: A K
authors.initials: AK
authors.lastname: Seth
authors.forename: C S
authors.initials: CS
authors.lastname: Chaturvedi
mesh_terms: D016022:Case-Control Studies; D002648:Child; D005458:Fluoride Poisoning / Q000150:complications / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D007564:Japan / Q000453:epidemiology; D012189:Retrospective Studies; D016136:Spina Bifida Occulta / Q000453:epidemiology* / Q000209:etiology