[The effect of antioxidants on functional brain disorders caused by low-intensity ionizing radiation].
The effects of daily intraperitoneal injections of alpha-tocopherol (30 mg/kg per day) and synthetic antioxidant IHFAN-30 (30 mg/day) in rats were compared during low-level ionizing radiation (10 days, dose rate 5 mGy/h, total dose 1.2 Gy). There were analysed: (1) amplitude of population spike of hippocampal slices; (2) endogenous phosphorylation in vitro of hippocampal synaptic proteins in the presence of cAMP; (3) formation, manifestation and reduction of food-procuring reflex. The findings showed that antioxidants made some correction of the functional state of hippocampal slices and cAMP-dependent phosphorylation system activity in brain cells from irradiated animals. No influence on training and memory functions was detected.
Godukhin
O V
OV
Arkhipov
V I
VI
Shipakina
T G
TG
Kalemenev
S V
SV
Burlakova
E B
EB
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology / Q000528:radiation effects*; D003214:Conditioning, Classical / Q000187:drug effects / Q000528:radiation effects; D004353:Drug Evaluation, Preclinical; D005071:Evoked Potentials / Q000187:drug effects / Q000528:radiation effects; D005720:Gamma Rays; D008297:Male; D008568:Memory / Q000187:drug effects / Q000528:radiation effects; D009419:Nerve Tissue Proteins / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D009930:Organic Chemicals; D010766:Phosphorylation / Q000187:drug effects / Q000528:radiation effects; D011833:Radiation Injuries, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D051381:Rats; D013570:Synaptic Membranes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D013997:Time Factors; D014810:Vitamin E / Q000627:therapeutic use
D000975:Antioxidants; C096398:IHFAN 30; D009419:Nerve Tissue Proteins; D009930:Organic Chemicals; D014810:Vitamin E
Issledovanie vliianiia antioksidantov na narusheniia funktsional'noĭ aktivnosti mozga, vyzvannye ioniziruiushchim izlucheniem maloĭ moshchnosti.