title: New insights into V(D)J recombination and its role in the evolution of the immune system.
authors.affiliation: Howard Hughes Medical Institute, Department of Medicine, Gwen Knapp Center for Lupus and Immunology Research, University of Chicago, Illinois 60637, USA.
authors.forename: C B
authors.initials: CB
authors.lastname: Thompson
mesh_terms: D000818:Animals; D005075:Biological Evolution; D002454:Cell Differentiation / Q000235:genetics; D004254:DNA Nucleotidyltransferases / Q000502:physiology; D004251:DNA Transposable Elements / Q000235:genetics; D004268:DNA-Binding Proteins; D000939:Epitopes / Q000235:genetics; D015322:Gene Rearrangement, B-Lymphocyte / Q000235:genetics* / Q000276:immunology; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics* / Q000276:immunology; D005803:Genes, Immunoglobulin / Q000235:genetics; D018398:Homeodomain Proteins; D006801:Humans; D007107:Immune System / Q000166:cytology* / Q000254:growth & development; D009687:Nuclear Proteins; D011506:Proteins / Q000235:genetics; D011947:Receptors, Antigen, B-Cell / Q000235:genetics; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000235:genetics; D011995:Recombination, Genetic / Q000235:genetics*; D012045:Regulatory Sequences, Nucleic Acid / Q000235:genetics; D045567:VDJ Recombinases; D014714:Vertebrates / Q000235:genetics / Q000276:immunology*
chemical_list: D004251:DNA Transposable Elements; D004268:DNA-Binding Proteins; D000939:Epitopes; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D011506:Proteins; C499311:RAG2 protein, human; D011947:Receptors, Antigen, B-Cell; D016693:Receptors, Antigen, T-Cell, alpha-beta; D016692:Receptors, Antigen, T-Cell, gamma-delta; C064655:V(D)J recombination activating protein 2; C064658:RAG-1 protein; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases