title: De novo acute myeloid leukemia in patients with Crohn's disease.
abstract: Crohn's disease (CD) has been occasionally reported to be associated with myelodysplastic syndromes (MDS) or acute myeloid leukaemia (AML). From October 1991 to June 1993, four AML patients with a previous history of CD but no history of MDS were referred to our institution. Three presented AML with a monoblastic proliferation (one AML4 and two AML5). Cytogenetic analysis revealed a normal karyotype in two patients, an inv(16) in another and a del(11)(q24-25) in the fourth. Interestingly, the three patients with AML4/AML5 had not received high doses of immunosuppressive agents, prior CD therapy ranging from 1 to 4 months sulfasalazine with additional azathioprine in one case.
authors.affiliation: Service Clinique des Maladies du Sang, Hôpital Saint Louis, Paris, France.
authors.forename: H
authors.initials: H
authors.lastname: Dombret
authors.forename: J P
authors.initials: JP
authors.lastname: Marolleau
mesh_terms: D000328:Adult; D003424:Crohn Disease / Q000150:complications*; D005260:Female; D006801:Humans; D007951:Leukemia, Myeloid / Q000150:complications*; D008297:Male; D015203:Reproducibility of Results