title: A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development.
abstract: Recent analyses of the cytochrome P450 steroid hydroxylases have established a key role for an orphan nuclear receptor, designated steroidogenic factor 1 (SF-1), in their coordinate, cell-selective expression. SF-1 was proposed to regulate the steroid hydroxylases by interacting with shared promoter elements in their 5'-flanking regions. During mouse embryonic development, SF-1 was expressed from the earliest stages of organogenesis of the steroidogenic tissues, suggesting a key role in steroidogenic cell differentiation. Finally, disruption of the gene encoding SF-1 revealed its essential function in the development of the adrenal glands and gonads and in pituitary gonadotrope function. These studies suggest that SF-1 acts at multiple levels of the reproductive axis to maintain reproductive competence.
authors.affiliation: Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
authors.forename: X
authors.initials: X
authors.lastname: Luo
authors.forename: Y
authors.initials: Y
authors.lastname: Ikeda
authors.forename: D S
authors.initials: DS
authors.lastname: Lala
authors.forename: L A
authors.initials: LA
authors.lastname: Baity
authors.forename: J C
authors.initials: JC
authors.lastname: Meade
authors.forename: K L
authors.initials: KL
authors.lastname: Parker
mesh_terms: D000311:Adrenal Glands / Q000196:embryology*; D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D004268:DNA-Binding Proteins / Q000502:physiology*; D004330:Drosophila / Q000196:embryology*; D029721:Drosophila Proteins; D004625:Embryo, Nonmammalian / Q000502:physiology; D005314:Embryonic and Fetal Development / Q000502:physiology; D051717:Fushi Tarazu Transcription Factors; D017344:Genes, Insect; D006066:Gonads / Q000196:embryology*; D018398:Homeodomain Proteins; D007030:Hypothalamo-Hypophyseal System / Q000502:physiology; D019476:Insect Proteins; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D018160:Receptors, Cytoplasmic and Nuclear; D054339:Steroidogenic Factor 1; D014157:Transcription Factors / Q000502:physiology*
chemical_list: D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D051717:Fushi Tarazu Transcription Factors; D018398:Homeodomain Proteins; D019476:Insect Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D054339:Steroidogenic Factor 1; D014157:Transcription Factors; C497169:ftz protein, Drosophila; C499712:nuclear hormone receptor FTZ-F1, Drosophila; C515058:steroidogenic factor 1, mouse