Interrelationships between lipoprotein(a) and other cardiovascular risk factors.
Lipoprotein(a) [Lp(a)] had been shown to be a strong independent risk factor for ischaemic heart disease. Our aim was to investigate the relationships between Lp(a) and other cardiovascular risk factors. 423 male miners (age 40 +/- 8 years) were analysed according to the following variables: age, arterial blood pressure, alcohol and cigarette consumption, total cholesterol and Lp(a). Analysis of the data was performed using the Kruskal-Wallis and Spearman tests. Analysis of variance showed statistical differences in Lp(a) levels with cigarette consumption (p < 0.02) and age (p < 0.001). No differences with corrected total cholesterol, blood pressure and alcohol consumption were found. Lp(a) and total cholesterol were correlated (p < 0.0001), but after correction for the estimated contribution of Lp(a) cholesterol this significant correlation disappeared. We conclude that male smokers have significantly lower Lp(a) values than non-smokers and those who quit. Our findings suggest that cigarette consumption is a probable environmental factor that might influence Lp(a) levels.
Rodríoguez Reguero
J J
JJ
Servicio de Cardiología, Hospital Central de Asturias, Oviedo, España.
Iglesias Cubero
G
G
Martinez Celada
M
M
Fueyo
J R
JR
Sanchez Posada
I
I
Braga
S
S
Cortina
A
A
D000328:Adult; D000367:Age Factors; D000428:Alcohol Drinking / Q000009:adverse effects; D000704:Analysis of Variance; D002784:Cholesterol / Q000097:blood; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood / Q000209:etiology*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
D017270:Lipoprotein(a); D002784:Cholesterol