title: Use of ambroxol and bromhexine as mucolytics for enhanced diffusion of furaltadone into tracheobronchial secretions in broilers.
abstract: 1. Ambroxol and bromhexine were evaluated as mucolytics and to enhance the passage of furaltadone into tracheobronchial secretions (TBS) in chronic complicated respiratory disease-affected broilers. 2. Viscosity of TBS was noticeably increased in the ambroxol-treated birds and only slightly increased in the bromhexine groups; however, the physical (nature) of TBS was superior in the ambroxol-treated broilers. 3. There was a clear increase in the passage of furaltadone into tracheobronchial secretions only in the ambroxol-treated birds. 4. Everyday use of ambroxol in broilers is discussed.
authors.affiliation: Department of Pharmacology, Faculty of Veterinary Medicine and Husbandry, Universidad Nacional Autónoma de México, (UNAM) Mexico City.
authors.forename: H
authors.initials: H
authors.lastname: Sumano
authors.forename: I
authors.initials: I
authors.lastname: Gracia
authors.forename: A
authors.initials: A
authors.lastname: Capistrán
authors.forename: G
authors.initials: G
authors.lastname: Meade
authors.forename: A
authors.initials: A
authors.lastname: Rivero
authors.forename: L
authors.initials: L
authors.lastname: Ruiz-Ramírez
mesh_terms: D000551:Ambroxol / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D001964:Bromhexine / Q000494:pharmacology*; D001980:Bronchi / Q000378:metabolism; D002645:Chickens; D004347:Drug Interactions; D005100:Expectorants / Q000494:pharmacology*; D009581:Nitrofurans / Q000493:pharmacokinetics*; D023303:Oxazolidinones; D012137:Respiratory System / Q000187:drug effects / Q000378:metabolism*; D014132:Trachea / Q000378:metabolism
chemical_list: D005100:Expectorants; D009581:Nitrofurans; D023303:Oxazolidinones; D000551:Ambroxol; C007795:furaltadon; D001964:Bromhexine