title: Increased heart rate response to laboratory-induced mental stress predicts frequency and duration of daily life ambulatory myocardial ischemia in patients with coronary artery disease.
abstract: This study assessed the relation between hemodynamic data during a standardized mental stressor and ambulatory ischemia to determine if laboratory-induced responses could predict the magnitude of daily life ischemia. Forty-two men and 11 women, aged 46 to 79 years (mean 61), with coronary artery disease and exercise-induced ischemia were studied. All patients underwent 24- to 48-hour ambulatory electrocardiographic (ECG) monitoring (mean 43 +/- 0.8 hours) and laboratory-induced mental stress using a public speaking task. Hemodynamic data were obtained at rest and every minute during mental stress. Thirty-three of 53 patients (62%) had at least 1 ischemic episode during ECG monitoring. In patients who had ambulatory ischemia, there was a mean number of 7.9 +/- 1.8 episodes (mean total duration 79.2 +/- 24.1 minutes/48 hours). Significant positive correlations were found for peak heart rate and changes in heart rate during mental stress and ambulatory ischemia (r = 0.353 to 0.462, p < 0.05) in patients who had ambulatory ischemia. There was no correlation between systolic blood pressure during mental stress and ambulatory ischemia. Results of this study demonstrate that heart rate response during laboratory-induced mental stress correlates with magnitude of ischemia on ambulatory ECG monitoring in patients with coronary artery disease.
authors.affiliation: Department of Cardiology, University of North Carolina School of Medicine, Chapel Hill, USA.
authors.forename: R
authors.initials: R
authors.lastname: Krittayaphong
authors.forename: K C
authors.initials: KC
authors.lastname: Light
authors.forename: P L
authors.initials: PL
authors.lastname: Biles
authors.forename: M N
authors.initials: MN
authors.lastname: Ballenger
authors.forename: D S
authors.initials: DS
authors.lastname: Sheps
mesh_terms: D000203:Activities of Daily Living; D000368:Aged; D003327:Coronary Disease / Q000503:physiopathology* / Q000523:psychology; D015716:Electrocardiography, Ambulatory; D005260:Female; D006339:Heart Rate; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000503:physiopathology*; D011237:Predictive Value of Tests; D013315:Stress, Psychological / Q000503:physiopathology*