Taurine in the olfactory system: effects of the olfactory toxicant dichlobenil.
Following intranasal instillation of 14C-taurine in C57B1/6 mice, there was a labelling of the olfactory neuroepithelium, axon bundles and axon layers in the olfactory bulb 4 and 24 h later, suggesting an axonal migration of radioactivity to the olfactory bulbs. In the olfactory bulbs the level of radioactivity was 45-times higher than that in the posterior part of the brain. In mice treated with the olfactory toxicant dichlobenil, inducing necrosis in the dorsomedial olfactory region, there was a dose-dependent decrease in the level of 14C-taurine and 3H-carnosine (derived from the precursor 3H-beta-alanine) in the olfactory bulb. The migration of 14C-taurine in the olfactory system of dichlobenil-dosed mice gradually recovered 3 - 8 weeks later although an atypical epithelium remained in the dorsomedial portion of the olfactory region. The results suggest a transient reduction of the migration of taurine in the olfactory system of mice following chemically-induced toxicity at this site.
Brittebo
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EB
Department of Pharmacology and Toxicology, Uppsala Biomedical Centre, Sweden.
Eriksson
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C
D000818:Animals; D001345:Autoradiography; D001370:Axonal Transport / Q000502:physiology; D001549:Benzamides / Q000633:toxicity*; D002336:Carnosine / Q000378:metabolism; D002855:Chromatography, Thin Layer; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D051379:Mice; D008810:Mice, Inbred C57BL; D009570:Nitriles; D009830:Olfactory Bulb / Q000166:cytology / Q000378:metabolism*; D013654:Taurine / Q000378:metabolism*; D015091:beta-Alanine / Q000378:metabolism
D001549:Benzamides; D009570:Nitriles; D015091:beta-Alanine; D013654:Taurine; D002336:Carnosine; D003577:Cytochrome P-450 Enzyme System; C055869:dichlobanil