False-positive and false-negative rates in meconium drug testing.
To determine the number of false-negative results produced by inefficient extraction of drugs from meconium, three published procedures were compared by using previously confirmed positive and negative meconium specimens. The methods were not equivalent in their ability to extract drugs from the matrix. To determine the number of false positives reported by the use of screen-only (unconfirmed) results, 535 screen-positive meconium specimens were subjects to confirmation by gas chromatography-mass spectrometry. Fifty-seven percent of the samples were confirmed positive for one or more of the drugs under investigation, showing that a false-positive rate as high as 43% may exist when unconfirmed screening results are used.
Moore
C
C
US Drug Testing Laboratories, Chicago, IL 60612, USA.
Lewis
D
D
Leikin
J
J
D000662:Amphetamines / Q000032:analysis; D003042:Cocaine / Q000032:analysis / Q000378:metabolism; D013759:Dronabinol / Q000032:analysis / Q000378:metabolism; D017248:Enzyme Multiplied Immunoassay Technique; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D016231:Fluorescence Polarization Immunoassay; D008401:Gas Chromatography-Mass Spectrometry / Q000706:statistics & numerical data*; D006801:Humans; D008470:Meconium / Q000737:chemistry*; D009294:Narcotics / Q000032:analysis; D004364:Pharmaceutical Preparations / Q000032:analysis*; D011247:Pregnancy; D015813:Substance Abuse Detection / Q000379:methods*
D000662:Amphetamines; D009294:Narcotics; D004364:Pharmaceutical Preparations; D013759:Dronabinol; D003042:Cocaine