title: Transmission blocking immunity as observed in a feeder system and serological reactivity to Pfs 48/45 and Pfs230 in field sera.
abstract: Monoclonal antibodies (mAbs) and human sera from gametocyte carriers were applied in the bio-assay to test for their transmission-blocking capacity. Competition ELISA's have been developed for the detection of natural transmission blocking antibodies. Approximately 55% of the sera blocking in the bio-assay gave positive results in these competition ELISA's.
authors.affiliation: University of Nijmegen, Department of Medical Microbiology, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Roeffen
authors.forename: T
authors.initials: T
authors.lastname: Lensen
authors.forename: B
authors.initials: B
authors.lastname: Mulder
authors.forename: K
authors.initials: K
authors.lastname: Teelen
authors.forename: R
authors.initials: R
authors.lastname: Sauerwein
authors.forename: W
authors.initials: W
authors.lastname: Eling
authors.forename: J H
authors.initials: JH
authors.lastname: Meuwissen
authors.forename: P
authors.initials: P
authors.lastname: Beckers
mesh_terms: D000328:Adult; D000913:Antibodies, Protozoan / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006801:Humans; D007106:Immune Sera / Q000276:immunology*; D016778:Malaria, Falciparum / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D000954:Antigens, Surface; D007106:Immune Sera