title: Acute fatal deterioration in putaminal hemorrhage.
abstract: BACKGROUND
  Clinical deterioration in patients with spontaneous intracerebral hemorrhage has rarely been studied. It has been previously thought that intracranial hematomas bleed in a monophasic fashion. Recent studies have demonstrated continuous active bleeding within hours after the event, resulting in enlargement of the hematoma. However, acute sudden and fatal deterioration suggesting a rebleed is rarely reported.
  
  
  METHODS
  An 84-year-old man was admitted with a moderate-size hemorrhage in the putamen and was treated for hypertension during the first day of admission. He acutely demonstrated extensor posturing and light-fixed pupils. Repeat CT scan showed massive enlargement of the intracranial hematoma and extension into the ventricles causing acute hydrocephalus. A 72-year-old man was admitted with a mid-size hemorrhage in the putamen. Acute deterioration with loss of all brain stem reflexes except for cornea reflexes was associated with a large increase in volume of the hematoma, 7 hours after the initial hemorrhage. An 85-year-old woman was admitted with a small hemorrhage in the putamen and recovered to be able to walk unassisted. She suddenly died from a recurrent massive putaminal hemorrhage 2 weeks after the ictus.
  
  
  CONCLUSIONS
  Patients with spontaneous intracerebral hemorrhage in the putamen may die acutely from fatal catastrophic enlargement of the initial hematoma hours to days after the ictus. In some patients with spontaneous intracerebral hemorrhage and clinical deterioration, rebleeding may be a possible mechanism.
authors.affiliation: Department of Neurology, Saint Mary's Hospital, Mayo Medical Center, Rochester, Minn. 55905, USA.
authors.forename: E F
authors.initials: EF
authors.lastname: Wijdicks
authors.forename: J R
authors.initials: JR
authors.lastname: Fulgham
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002543:Cerebral Hemorrhage / Q000150:complications / Q000473:pathology*; D002552:Cerebral Ventricles / Q000473:pathology; D018450:Disease Progression; D017809:Fatal Outcome; D005260:Female; D006406:Hematoma / Q000150:complications / Q000473:pathology; D006801:Humans; D006849:Hydrocephalus / Q000209:etiology; D008297:Male; D011699:Putamen / Q000473:pathology*; D012008:Recurrence