Effects of unilateral lesion of the nucleus basalis magnocellularis on carbachol- and serotonin-stimulated [3H]inositolmonophosphate accumulation in rat fronto-parietal cortex.
We examined the effects of ibotenic acid induced unilateral lesion of the nucleus basalis magnocellularis (nBM) on carbachol- and serotonin-stimulated phosphoinositide (PI) breakdown in miniprisms obtained from rat fronto-parietal cortex 1 week following the lesion. Lesion-side muscarinic and serotoninergic receptor responsivity to agonist increased linearly relative to the severity of the nBM lesion as measured by choline acetyltransferase (ChAT) activity. These results provide further evidence for an interaction between central cholinergic and serotoninergic neurons.
Erfurth
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Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02142-1323, USA.
Holmes
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TC
D000818:Animals; D002217:Carbachol / Q000494:pharmacology*; D005625:Frontal Lobe / Q000378:metabolism; D007051:Ibotenic Acid / Q000494:pharmacology*; D007700:Kinetics; D008297:Male; D010296:Parietal Lobe / Q000378:metabolism; D010716:Phosphatidylinositols / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000494:pharmacology*; D013377:Substantia Innominata / Q000187:drug effects / Q000502:physiology*
D010716:Phosphatidylinositols; D007051:Ibotenic Acid; D012701:Serotonin; D002217:Carbachol