title: Gut-derived mediators of multiple organ failure: platelet-activating factor and interleukin-6.
abstract: Laboratory studies suggest that the postischaemic gut serves as a priming bed for circulating neutrophils that provoke multiple organ failure. Platelet-activating factor, generated by phospholipase A2, appears to be active in priming neutrophils in the gut. Interleukin-6 also appears to be elaborated by the postischaemic gut, but may be even more important in distant organs via promoting neutrophil-mediated organ dysfunction.
authors.affiliation: Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Centre, Colorado 80204, USA.
authors.forename: W L
authors.initials: WL
authors.lastname: Biffl
authors.forename: E E
authors.initials: EE
authors.lastname: Moore
authors.forename: F A
authors.initials: FA
authors.lastname: Moore
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000502:physiology*; D009102:Multiple Organ Failure / Q000097:blood / Q000276:immunology* / Q000503:physiopathology*; D009504:Neutrophils / Q000276:immunology; D010972:Platelet Activating Factor / Q000502:physiology*; D051381:Rats; D013152:Splanchnic Circulation
chemical_list: D015850:Interleukin-6; D010972:Platelet Activating Factor