Immunocytochemistry of Kaposi's sarcoma-like tumor cells from pigtailed macaques with simian AIDS.
Some macaques infected with SRV-2 developed SAIDS and RF, a Kaposi's sarcoma (KS)-like tumor. We investigated the immunophenotypic markers of this SAIDS-associated retroperitoneal fibromatosis (RF). RF tumor is characterized by proliferation of spindle cells accompanying inflammatory cell infiltrates, fibroblasts, and endothelial cells. RF spindle cells in tumor tissues revealed several immunobiologic characteristics similar to vascular smooth-muscle cells or myofibroblasts based on positive immunoreactivity of smooth-muscle alpha-actin and desmin. The majority of cultured RF spindle cells also expressed specific markers for vascular smooth muscle. These results suggest that the RF spindle cells are derived from vascular smooth-muscle cells. Furthermore, RF tissues and cells were persistently infected with SRV-2, which may play an important role in viral etiology of AIDS-associated neoplasm in this macaque model.
Tsai
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CC
Regional Primate Research Center, University of Washington, Seattle, USA.
Wu
H
H
Meng
F
F
D000818:Animals; D000906:Antibodies; D000911:Antibodies, Monoclonal; D002454:Cell Differentiation; D002455:Cell Division; D018221:Fibromatosis, Abdominal / Q000209:etiology / Q000473:pathology*; D006801:Humans; D007150:Immunohistochemistry; D007381:Intermediate Filament Proteins / Q000032:analysis; D008254:Macaca nemestrina; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000473:pathology*; D016097:Simian Acquired Immunodeficiency Syndrome / Q000150:complications*; D015302:Simian Immunodeficiency Virus / Q000302:isolation & purification
D000906:Antibodies; D000911:Antibodies, Monoclonal; D007381:Intermediate Filament Proteins