Recombinant human erythropoietin stimulates tubular reabsorption of sodium in anesthetized rabbits.
To determine whether recombinant human erythropoietin (rHuEPO) exerts a direct vasoconstrictive effect on renal arteries or affects renal function, we measured renal hemodynamics and renal function during a 30-min intrarenal infusion of rHuEPO in anesthetized rabbits without renal failure. Intrarenal infusion of rHuEPO at a rate of 100 U/min did not alter mean arterial pressure, renal blood flow, or renal vascular resistance, as compared with controls treated with vehicle. There were no significant rHuEPO-associated changes in glomerular filtration rate, filtration fraction, or arterial hematocrit. However, urine volume, urinary excretion of sodium and potassium, and fractional sodium excretion were significantly reduced by intrarenal infusion of rHuEPO. These observations indicate that rHuEPO has no direct effects on mean arterial pressure or renal hemodynamics, but that it stimulates net tubular sodium reabsorption, and reduces urine volume and urinary excretion of sodium and potassium in anesthetized rabbits without renal failure.
Nushiro
N
N
Second Department of Internal Medicine, Gunma University School of Medicine, Maebashi, Japan.
Sakamaki
T
T
Hoshino
J
J
Nakamura
T
T
Sakamoto
H
H
Imai
Y
Y
Seino
M
M
Omata
K
K
Sekino
H
H
Abe
K
K
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D004921:Erythropoietin / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D007668:Kidney / Q000098:blood supply / Q000187:drug effects* / Q000502:physiology; D007677:Kidney Function Tests; D007684:Kidney Tubules / Q000187:drug effects / Q000502:physiology; D011817:Rabbits; D011994:Recombinant Proteins / Q000494:pharmacology; D012964:Sodium / Q000652:urine*; D014655:Vascular Resistance / Q000187:drug effects
D011994:Recombinant Proteins; D004921:Erythropoietin; D012964:Sodium