title: [Veno-occlusive liver disease due to intake of Senecio vulgaris tea].
abstract: Veno-occlusive liver disease (VOLD) is a cause of portal hypertension by non thrombotic obstruction of hepatic venous drainage attributed to multiple etiologies (toxic, irradiation, antineoplastic, conditioning for bone marrow transplantation). One case of VOLD in a senile patient due to continuous two year consumption of Senecio vulgaris tea is reported. This compound, which has a high pyrrolizidine alkaloid content induced a subacute course of portal hypertension and death. The clinicopathologic features of VOLD and the etiopathogenesis in relation to the pyrrolizidine alkaloids present in Senecio vulgaris are discussed. The need for considering the history of medicinal plant ingestion in patients under portal hypertension studies are strongly recommended as is the advice regarding the possible dangers involved in the inappropriate use of remedies provided by herbalists.
authors.affiliation: Servicio de Medicina Interna, Hospital Provincial de Badajoz.
authors.forename: A
authors.initials: A
authors.lastname: Ortiz Cansado
authors.forename: E
authors.initials: E
authors.lastname: Crespo Valadés
authors.forename: P
authors.initials: P
authors.lastname: Morales Blanco
authors.forename: J
authors.initials: J
authors.lastname: Sáenz de Santamaría
authors.forename: J M
authors.initials: JM
authors.lastname: González Campillejo
authors.forename: T
authors.initials: T
authors.lastname: Ruiz Téllez
mesh_terms: D000368:Aged; D001628:Beverages / Q000009:adverse effects*; D001706:Biopsy; D006504:Hepatic Veno-Occlusive Disease / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D006801:Humans; D006975:Hypertension, Portal / Q000209:etiology; D008099:Liver / Q000473:pathology; D008297:Male; D010947:Plants, Toxic; D011763:Pyrrolizidine Alkaloids / Q000009:adverse effects*; D012674:Senecio
chemical_list: D011763:Pyrrolizidine Alkaloids
vernacular_title: Enfermedad venooclusiva hepática por ingestión de infusiones de Senecio vulgaris.