title: Microalbuminuria: prognostic and therapeutic implications in diabetic and hypertensive pregnancy.
abstract: Microalbuminuria is defined as urinary excretion of albumin that is persistently above normal, although below the sensitivity of conventional semiquantative test strips. Several studies have reported that Type 1 diabetic patients with microalbuminuria are apparently more likely to develop diabetic nephropathy eventually progressing to renal failure. Microalbuminuria is also a strong predictor of mortality in Type 2 diabetes, and is correlated with increased blood pressure in patients with benign essential hypertension. Radioimmunoassay revealed a significantly higher urinary albumin excretion rate in normal pregnant women in the third trimester of pregnancy, compared to the second and first, and compared to non-pregnant women. Microalbuminuria was found in 30% of women who had a record of gestational diabetes mellitus. Published results are controversial regarding the assumption that microalbuminuria is an early predictor of pregnancy-induced hypertensive complications.
authors.affiliation: Department of Obstetrics and Gynecology, Beilinson Medical Center, Petah Tiqva, Israel.
authors.forename: J
authors.initials: J
authors.lastname: Bar
authors.forename: M
authors.initials: M
authors.lastname: Hod
authors.forename: A
authors.initials: A
authors.lastname: Erman
authors.forename: S
authors.initials: S
authors.lastname: Friedman
authors.forename: Y
authors.initials: Y
authors.lastname: Ovadia
mesh_terms: D000419:Albuminuria / Q000628:therapy; D015415:Biomarkers / Q000652:urine; D016640:Diabetes, Gestational / Q000628:therapy / Q000652:urine*; D005260:Female; D006801:Humans; D006973:Hypertension / Q000628:therapy / Q000652:urine*; D011237:Predictive Value of Tests; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000628:therapy / Q000652:urine*; D011254:Pregnancy in Diabetics / Q000628:therapy / Q000652:urine*; D011379:Prognosis; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers