title: [Treatment of solid tumor by a small amount of direct current].
abstract: Solid tumor treatment was given in our animal laboratory to determine the mechanism of tumor disappearance by direct electric current, and clinical trials were done on 9 far advanced recurrent rectal cancers. Solid tumors of Yoshida sarcoma in Donryu rat were treated by 1 mA of constant direct current for 1 hour a day, for 4 days. The tumors disappeared in 13/16 within 21 days. Positive results of DNA Nick-end labeling and ladder patterns in the gel electrophoresis of DNA were observed in the regressing tumor specimen. It is considered that apoptosis is the one of the mechanisms of a disappearing tumor. As for the clinical trial concern, in 9 cases of rectal cancer, one CR and 5 PR were seen.
authors.affiliation: Dept. of Surgery II, School of Medicine, Nagoya University.
authors.forename: K
authors.initials: K
authors.lastname: Ito
authors.forename: C L
authors.initials: CL
authors.lastname: Ye
authors.forename: K
authors.initials: K
authors.lastname: Kondou
authors.forename: S
authors.initials: S
authors.lastname: Akiyama
authors.forename: H
authors.initials: H
authors.lastname: Takagi
authors.forename: H
authors.initials: H
authors.lastname: Hirota
authors.forename: T
authors.initials: T
authors.lastname: Endo
authors.forename: G
authors.initials: G
authors.lastname: Itoh
authors.forename: M
authors.initials: M
authors.lastname: Suzuki
authors.forename: S
authors.initials: S
authors.lastname: Ikeda
mesh_terms: D000368:Aged; D000818:Animals; D017209:Apoptosis; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D051381:Rats; D012004:Rectal Neoplasms / Q000628:therapy*; D012517:Sarcoma, Yoshida / Q000473:pathology / Q000628:therapy*