title: Mechanisms of increase in plasma triacylglycerol concentrations as a result of high carbohydrate intakes in patients with non-insulin-dependent diabetes mellitus.
abstract: To determine the mechanisms of increase in plasma triacylglycerol concentrations after high dietary intakes of carbohydrates, 10 men with non-insulin-dependent diabetes mellitus (NIDDM) were fed an isoenergetic high-carbohydrate diet (55% of energy as carbohydrate and 30% as fat) and a high-monounsaturated-fat diet (45% of energy as fat and 40% as carbohydrates) for 6 wk in a randomized, crossover manner. The high-carbohydrate diet raised fasting plasma triacylglycerol concentrations by 26% (P = 0.007) but did not affect postheparin lipoprotein lipase (P = 0.2) or hepatic lipase activities (P = 0.9). The oral-fat-tolerance test labeled with retinyl palmitate also revealed no differences in postprandial plasma triacylglycerol (P = 0.37) or retinyl palmitate clearances (P = 0.34) between the two diets. We conclude that the increase in plasma triacylglycerol concentrations with high-carbohydrate diets in men with NIDDM is not due to reduced lipolysis or diminished postprandial clearance of triacylglycerol-rich lipoproteins but is primarily due to increased hepatic secretion of very-low-density-lipoprotein triacylglycerols.
authors.affiliation: Center for Human Nutrition, University of Texas Southwestern Medical Center at Dallas 75235-9052, USA.
authors.forename: B
authors.initials: B
authors.lastname: Blades
authors.forename: A
authors.initials: A
authors.lastname: Garg
mesh_terms: D000368:Aged; D002784:Cholesterol / Q000097:blood; D018592:Cross-Over Studies; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000178:diet therapy; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage; D005231:Fatty Acids, Unsaturated / Q000008:administration & dosage; D006801:Humans; D008049:Lipase / Q000378:metabolism; D008066:Lipolysis; D008071:Lipoprotein Lipase / Q000097:blood; D008079:Lipoproteins, VLDL / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D014280:Triglycerides / Q000097:blood*
chemical_list: D004040:Dietary Carbohydrates; D004042:Dietary Fats, Unsaturated; D005231:Fatty Acids, Unsaturated; D008079:Lipoproteins, VLDL; D014280:Triglycerides; D002784:Cholesterol; D008049:Lipase; D008071:Lipoprotein Lipase