title: Gonadotropin-releasing hormone neurons in the rhesus macaque are not immunoreactive for the estrogen receptor.
abstract: The issue of whether gonadotropin-releasing hormone (GnRH) neurons in the primate contain the estrogen receptor was examined by immunocytochemistry using prepubertal and adult (intact and ovariectomized) female rhesus macaques. No GnRH neurons were found to contain nuclei that were immunoreactive for the estrogen receptor. These results confirm in primates what has been reported in other species and leave open the question of how the effects of gonadal steroids on GnRH neurons are mediated.
authors.affiliation: Department of Neurology, University of Michigan, Ann Arbor, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Sullivan
authors.forename: J W
authors.initials: JW
authors.lastname: Witkin
authors.forename: M
authors.initials: M
authors.lastname: Ferin
authors.forename: A J
authors.initials: AJ
authors.lastname: Silverman
mesh_terms: D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis*; D007150:Immunohistochemistry; D008253:Macaca mulatta / Q000378:metabolism*; D009474:Neurons / Q000737:chemistry*; D010053:Ovary / Q000502:physiology; D011960:Receptors, Estrogen / Q000032:analysis*; D012741:Sexual Maturation; D013045:Species Specificity
chemical_list: D011960:Receptors, Estrogen; D007987:Gonadotropin-Releasing Hormone