Localization of MODY3 to a 5-cM region of human chromosome 12.
Maturity-onset diabetes of the young (MODY) is a heterogeneous disorder that appears to be characterized by a primary defect in insulin secretion. Mutations in an unknown locus (MODY1) on chromosome 20 and the glucokinase gene (MODY2) on chromosome 7 can cause this form of non-insulin-dependent diabetes. Recent genetic studies have identified a third locus on chromosome 12 (MODY3) that is linked to MODY in a group of French families. We have identified three families from Denmark, Germany, and the U.S. (Michigan) showing evidence of linkage with MODY3 and a family from Japan showing suggestive evidence. Analysis of key recombinants in these families localized MODY3 to a 5-cM interval between the markers D12S86 and D12S807/D12S820.
Menzel
S
S
Howard Hughes Medical Institute, University of Chicago, Illinois, USA.
Yamagata
K
K
Trabb
J B
JB
Nerup
J
J
Permutt
M A
MA
Fajans
S S
SS
Menzel
R
R
Iwasaki
N
N
Omori
Y
Y
Cox
N J
NJ
D000328:Adult; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D003718:Denmark; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D008040:Genetic Linkage; D005858:Germany; D006801:Humans; D007564:Japan; D009154:Mutation; D010375:Pedigree; D010641:Phenotype; D014481:United States