Radiation-induced primary brain lymphoma: a case report.
A patient who developed primary brain lymphoma 6 years following whole brain irradiation due to a low-grade glioma is described. The patient had no evidence of congenital or acquired immunodeficiency state and achieved a good and prompt response to aggressive chemotherapy, including high-dose methotrexate. The previous radiation therapy is implicated in the etiology of the lymphoma because of the geometric coincidence, the relatively long latency period and the different histology. A brief review of current literature is reported.
Stein
M E
ME
Chemotherapy Unit, Northern Israel Oncology Center, Haifa, Israel.
Haim
N
N
Ben-Shachar
M
M
Goldsher
D
D
Bernstein
Z
Z
Ben-Arieh
Y
Y
Kuten
A
A
D000328:Adult; D001932:Brain Neoplasms / Q000209:etiology* / Q000473:pathology / Q000532:radiotherapy*; D005910:Glioma / Q000532:radiotherapy*; D006801:Humans; D008223:Lymphoma / Q000209:etiology* / Q000473:pathology; D008297:Male; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000473:pathology; D011878:Radiotherapy / Q000009:adverse effects