Nucleolar organizer regions: a new prognostic factor for upper tract urothelial cancer.
OBJECTIVE
The prognostic significance of argyrophilic staining in the nucleolar organizer regions was studied in 63 patients with primary urothelial tumors of the renal pelvis and ureter.


METHODS
Silver staining of paraffin embedded sections was performed using a 1-step technique.


RESULTS
The prognosis for patients with a mean number of argyrophilic nucleolar organizer region proteins per nucleus (argyrophilic nucleolar organizer region score) of 8 or greater was significantly worse than that for patients with a score of less than 8 (P <0.001).


CONCLUSIONS
Argyrophilic nucleolar organizer region score is a new prognostic factor in primary urothelial tumors of the renal pelvis and ureter, and it is particularly useful for patients with invasive tumors.
Jinza
S
S
Department of Urology, Yokohama City University School of Medicine, Kanagawa-ken, Japan.
Iki
M
M
Noguchi
S
S
Shuin
T
T
Kubota
Y
Y
Takano
Y
Y
Masuda
M
M
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007680:Kidney Neoplasms / Q000401:mortality / Q000473:pathology*; D007682:Kidney Pelvis / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011379:Prognosis; D016622:Silver Staining; D015996:Survival Rate; D014516:Ureteral Neoplasms / Q000401:mortality / Q000473:pathology*