title: The treatment of advanced neuroblastoma. Results of the Spanish Neuroblastoma Study Group (SNSG) studies.
abstract: The Spanish Neuroblastoma Study Group has conducted a study on advanced neuroblastoma (N-I-87), which included 33 stage III and 60 stage IV neuroblastoma children more than 1 year of age, enrolled between October 1987 and April 1992. They were staged according to Evans and treated with induction chemotherapy (IC) consisting of 3 courses of cyclophosphamide-doxorubicin alternating with 3 of high-dose cisplatin-teniposide. Evaluation after IC and surgery demonstrated an overall response rate of 88% for stage III and 69% for stage IV. In the latter, complete responses and good partial responses were 33 and 14%, respectively. After surgery, children received maintenance chemotherapy (all stage III except 2 and 30 stage IV) or autologous bone marrow transplantation (ABMT) (11 stage IV), the distribution was not randomised. Probability of survival at 5 years was 0.60 +/- 0.12 for stage III and 0.24 +/- 0.07 for stage IV. A significant difference in survival at 5 years was found between "good responders" and "non-responders" to initial chemotherapy.
authors.affiliation: Pediatric Oncology Unit, Hospital Infantil, Valencia, Spain.
authors.forename: V
authors.initials: V
authors.lastname: Castel
authors.forename: P
authors.initials: P
authors.lastname: García-Miguel
authors.forename: C
authors.initials: C
authors.lastname: Melero
authors.forename: A
authors.initials: A
authors.lastname: Navajas
authors.forename: S
authors.initials: S
authors.lastname: Navarro
authors.forename: J
authors.initials: J
authors.lastname: Molina
authors.forename: M D
authors.initials: MD
authors.lastname: Badal
authors.forename: J I
authors.initials: JI
authors.lastname: Ruiz-Jimenez
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D017024:Chemotherapy, Adjuvant; D002648:Child; D002675:Child, Preschool; D006801:Humans; D007223:Infant; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D015996:Survival Rate