Poly(ADP-ribose) polymerase: structure-function relationship.
Dissection of the human poly(ADP-ribose) polymerase (PARP) molecule in terms of its structure-function relationship has proved to be an essential step towards understanding the biological role of poly(ADP-ribosylation) as a cellular response to DNA damage in eukaryotes. Current approaches aimed at elucidating the implication of this multifunctional enzyme in the maintenance of the genomic integrity will be presented.
Masson
M
M
Ecole Supérieure de Biotechnologie de Strasbourg, UPR 9003 du CNRS, Illkirch, France.
Rolli
V
V
Dantzer
F
F
Trucco
C
C
Schreiber
V
V
Fribourg
S
S
Molinete
M
M
Ruf
A
A
Miranda
E A
EA
Niedergang
C
C
D000818:Animals; D002384:Catalysis; D002645:Chickens; D003460:Crystallization; D018360:Crystallography, X-Ray; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000502:physiology; D015894:Genome, Human; D006367:HeLa Cells; D006801:Humans; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry* / Q000502:physiology*; D017434:Protein Structure, Tertiary; D011994:Recombinant Proteins / Q000737:chemistry; D013329:Structure-Activity Relationship; D014162:Transfection
D004268:DNA-Binding Proteins; D011994:Recombinant Proteins; D011065:Poly(ADP-ribose) Polymerases