An intermediate for chloroquine analogs: (E)-2-(4,7-dichloro-2-quinolinyl)-3-(dimethylamino)-2-propenal.
The title compound C14H12C12N2O, has been shown to have an E configuration about the double bond in the propenal moiety. Significant delocalization of the lone pair on the N atom of the dimethylamino group into the pi system of this moiety is indicated by the planarity about this N atom.
Mague
J T
JT
Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.
De
D
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Krogstad
D J
DJ
D000171:Acrolein / Q000031:analogs & derivatives* / Q000737:chemistry; D000962:Antimalarials / Q000737:chemistry*; D002738:Chloroquine / Q000031:analogs & derivatives*; D018360:Crystallography, X-Ray; D011804:Quinolines / Q000737:chemistry*; D013237:Stereoisomerism
C096578:2-(4,7-dichloro-2-quinolinyl)-3-(dimethylamino)-2-propenal; D000962:Antimalarials; D011804:Quinolines; D000171:Acrolein; C035317:4,7-dichloroquinoline; D002738:Chloroquine