Selective adherence of a sucralfate-tetracycline complex to gastric ulcers: implications for the treatment of Helicobacter pylori.
The adherence of a sucralfate-tetracycline complex to gastric ulcers and to nearby non-ulcer sites was determined in the rabbit antrum. Persistent gastric ulcers were produced by a previously described method. The presence of the complex was assessed 1 and 4 h after dosing. Drug adherence was determined by quantitation of aluminum in stomach wall biopsies. Significantly more aluminum adhered to ulcer sites than to nearby non-ulcer sites. Adherence of the complex did not significantly decrease from 1 to 4 h. The complexation of tetracycline to sucralfate did not alter the selective adherence of sucralfate to gastric ulcers, providing a mechanism of ulcer site-selective drug delivery in the treatment of Helicobacter pylori gastric ulcer disease.
Yokel
R A
RA
College of Pharmacy, University of Kentucky, Lexington, USA.
Dickey
K M
KM
Goldberg
A H
AH
D000535:Aluminum / Q000378:metabolism; D000818:Animals; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D000897:Anti-Ulcer Agents / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004338:Drug Combinations; D016503:Drug Delivery Systems; D016481:Helicobacter Infections / Q000188:drug therapy / Q000378:metabolism* / Q000382:microbiology; D016480:Helicobacter pylori; D008297:Male; D011817:Rabbits; D013276:Stomach Ulcer / Q000188:drug therapy / Q000378:metabolism* / Q000382:microbiology; D013392:Sucralfate / Q000493:pharmacokinetics* / Q000627:therapeutic use; D013752:Tetracycline / Q000493:pharmacokinetics* / Q000627:therapeutic use
D000900:Anti-Bacterial Agents; D000897:Anti-Ulcer Agents; D004338:Drug Combinations; D013392:Sucralfate; D000535:Aluminum; D013752:Tetracycline