Molecular chaperones. Resurrection or destruction?
Recent studies implicate Hsp104/Clp family chaperones in both protein disaggregation and protein degradation. How do these homologous ring-shaped complexes function in such different ways?
Horwich
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Department of Genetics and HHMI, Boyer Centre, New Haven, Connecticut 06510, USA.
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D006360:Heat-Shock Proteins / Q000502:physiology; D018832:Molecular Chaperones / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D013329:Structure-Activity Relationship
D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D011506:Proteins; D029701:Saccharomyces cerevisiae Proteins; C070972:HsP104 protein, S cerevisiae; D000251:Adenosine Triphosphatases