[Pharmacokinetics of SK & F 104864 in experimental animals. II. Tissue distribution].
After intravenous bolus injection of a camptothecin derivative, SK & F 104864 (topotecan), at 20 mg/kg into Sarcoma 180 bearing mice, the tissue concentration of total topotecan (SK & F 104864 plus SK & F 105992) in the mice decreased bi-exponentially, and the beta half-lives in most tissues were longer than those in plasma. The AUCs of total topotecan were extremely large in the kidney, that was followed by the pancreas > intestine > stomach > spleen > liver > thymus > lung > tumor > uterus > plasma. The concentration of total topotecan after 24 hours decreased to less than 2% of the peak level in most tissues except the kidney.
Fujita
H
H
Dept. of Bacteriology, School of Dental Medicine, Tsurumi University.
Okamoto
M
M
Takao
A
A
Abe
H
H
Ishii
R
R
Arase
H
H
D000818:Animals; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002166:Camptothecin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D005260:Female; D007275:Injections, Intravenous; D051379:Mice; D008813:Mice, Inbred ICR; D012510:Sarcoma 180 / Q000378:metabolism*; D014018:Tissue Distribution; D019772:Topotecan
D000970:Antineoplastic Agents; D019772:Topotecan; D002166:Camptothecin