Meta-analyses and overviews of randomised trials.
The number of meta-analyses or overviews appearing in the literature is rapidly increasing. Because of the problems inherent in non-randomised studies, which are not diminished by using meta-analysis techniques, this paper only refers to meta-analyses of randomised trials. Examples are given of the value of meta-analyses of randomised trials in many different circumstances and the different methods that have been used are discussed. The most reliable type of meta-analysis uses individual patient data and includes all trials fitting the pre-defined criteria, published and unpublished. As with a single randomised trial, large numbers of randomised patients are needed to give reliable results. Well-conducted meta-analyses or overviews are the best method of summarising all available unbiased evidence on the relative effects of treatments.
Richards
S M
SM
ICRF/MRC Clinical Trial Service Unit, Radcliffe Infirmary, Oxford, UK.
D006801:Humans; D015201:Meta-Analysis as Topic; D016032:Randomized Controlled Trials as Topic; D015203:Reproducibility of Results