title: Postural stability differentiates "lower body" from idiopathic parkinsonism.
abstract: BACKGROUND
  Patients with an akinetic Parkinson syndrome of the lower extremities and a poor response to L-DOPA have been described as "lower body Parkinsonism" (LBP). These patients are characterized by frequent fallings and poor balance.
  
  
  METHODS
  We have studied body sway with static (force platform) and dynamic (Equitest) posturography in 11 LBP patients, 6 of them revealing deep white matter lesions on MRI and 10 patients with advanced Parkinson's disease (PD) and compared performance with 30 age-matched controls.
  
  
  RESULTS
  When standing on a fixed support the postural performance of both patient groups lay within the normal range. The balance of LBP patients worsened in the static testing in the conditions "eyes open on foam" (p < 0.05) and "eyes closed on foam" (p < 0.0006, of 11 patients falling), whereas the balance of PD patients deteriorated only with "eyes closed on foam" (p < 0.05). Dynamic posturography confirmed these results in 6 different sensory conditions, clearly distinguishing the more unstable LBP patients from PD patients during "standing, eyes closed, foot support sway referenced" (p < 0.005).
  
  
  CONCLUSIONS
  We conclude, that postural adjustments in LBP patients are more disturbed than those in PD patients and posturography can be an additional tool for the differential diagnosis of Parkinson syndromes with gait disorders.
authors.affiliation: Department of Neurology, Ludwig-Maximilians-University of Munich, Germany.
authors.forename: C
authors.initials: C
authors.lastname: Trenkwalder
authors.forename: W
authors.initials: W
authors.lastname: Paulus
authors.forename: S
authors.initials: S
authors.lastname: Krafczyk
authors.forename: M
authors.initials: M
authors.lastname: Hawken
authors.forename: W H
authors.initials: WH
authors.lastname: Oertel
authors.forename: T
authors.initials: T
authors.lastname: Brandt
mesh_terms: D000368:Aged; D005260:Female; D005684:Gait; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000188:drug therapy; D011187:Posture; D012720:Severity of Illness Index
chemical_list: D007980:Levodopa