The effects of propofol on laryngeal reactivity and the haemodynamic response to laryngeal mask insertion.
The ease of the insertion of laryngeal mask and the haemodynamic response were assessed 2 min after induction of anaesthesia with either propofol 2.5 mg kg-1 or thiopentone 4.0 mg kg-1 in 38 ASA I premedicated patients. The inserting conditions scored as excellent, good, poor and unable to insert were significantly better with propofol than with thiopentone (P < 0.001). Insertion of the laryngeal mask was followed by a transient but significant increase in both systolic (P < 0.05) and diastolic (P < 0.01) arterial pressure in the thiopentone group; there was no comparable response in the propofol group. The heart rate varied little from baseline in both groups.
Acalovschi
I
I
University Department of Anaesthesia and Intensive Therapy, Spitalul Clinic, Cluj-Napoca, Romania.
Miclescu
A
A
Bugov
L
L
D000759:Adjuvants, Anesthesia / Q000008:administration & dosage; D000328:Adult; D018686:Anesthetics, Intravenous / Q000008:administration & dosage / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects*; D003975:Diazepam / Q000008:administration & dosage; D017558:Elective Surgical Procedures; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D017214:Laryngeal Masks; D007830:Larynx / Q000187:drug effects*; D008297:Male; D008614:Meperidine / Q000008:administration & dosage; D008875:Middle Aged; D011229:Preanesthetic Medication; D015742:Propofol / Q000008:administration & dosage / Q000494:pharmacology*; D012018:Reflex / Q000187:drug effects*; D013874:Thiopental / Q000008:administration & dosage / Q000494:pharmacology
D000759:Adjuvants, Anesthesia; D018686:Anesthetics, Intravenous; D008614:Meperidine; D013874:Thiopental; D003975:Diazepam; D015742:Propofol