The relation between conduction velocity and axonal length.
Motor evoked potentials (MEPs) obtained by electrical root stimulation and F waves were used to examine the proximal nerve conduction velocity (CV) to tibialis anterior (TA), extensor digitorum brevis (EDB), flexor carpi radialis (FCR), and abductor pollicis brevis (APB) muscles in 40 humans. By subtracting motor latencies obtained by stimulating the peripheral nerve at the same point from the F-wave and MEP latencies, we could measure the CV over identical proximal segments. It was found that proximal CV to TA and FCR was significantly higher than to EDB and APB, respectively. Combining the data of the proximal CV to all four muscles in relation with axonal length resulted in a highly significant inverse relationship (r2 = 0.77). Thus the axonal length explained to a large extent the higher CV of the arm nerves and also the inverse relation between body height and CV. The distal CV was always lower than proximal CV; however, there was no support for an additional effect of this gradient in explaining the relationship between CV and height since it was constant for all body heights.
Zwarts
M J
MJ
Martini Hospital, Department of Clinical Neurophysiology, Groningen, Holland.
Guechev
A
A
D000200:Action Potentials; D000293:Adolescent; D000328:Adult; D001132:Arm; D001369:Axons / Q000648:ultrastructure*; D004558:Electric Stimulation; D019054:Evoked Potentials, Motor; D005260:Female; D006801:Humans; D007866:Leg; D008297:Male; D008475:Median Nerve / Q000502:physiology / Q000648:ultrastructure; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000502:physiology; D009431:Neural Conduction; D010543:Peroneal Nerve / Q000502:physiology / Q000648:ultrastructure; D011930:Reaction Time; D013997:Time Factors