[Efficacy of the granisetron/solumedrol combination in the control of drug-induced acute nausea and vomiting. Results of a prospective survey].
5 HT3 antagonist are effective drugs to control chemotherapy induced nausea and vomiting, but their optimum utilisation remain to be codify. In order to estimate efficacity of granisetron and solumedrol and to improve predictive factors of failure of antiserotoninergic agents, a prospective study have been realised 41 patients. During the first course of chemotherapy, 83% of patients presented less than two nausea and vomiting per day. Those results were the same from the first to the last course of chemotherapy. This study allowed to estimate anxiety of patients and maintain the hypothesis that more a antiemetic regimen is efficient less the predictive factors have a prognosis value.
Debrix
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I
Service de Pharmacie-Toxicologie, Hôpital Tènon, Paris.
Puteaux
S
S
Milleron
B
B
Becker
A
A
D000932:Antiemetics / Q000627:therapeutic use; D018931:Antineoplastic Agents, Hormonal / Q000008:administration & dosage / Q000627:therapeutic use; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D001984:Bronchial Neoplasms / Q000188:drug therapy; D004359:Drug Therapy, Combination; D005260:Female; D017829:Granisetron / Q000008:administration & dosage* / Q000627:therapeutic use; D006306:Health Surveys; D006801:Humans; D008297:Male; D008776:Methylprednisolone Hemisuccinate / Q000008:administration & dosage* / Q000627:therapeutic use; D008875:Middle Aged; D009325:Nausea / Q000139:chemically induced / Q000517:prevention & control*; D011446:Prospective Studies; D017366:Serotonin Receptor Agonists / Q000627:therapeutic use; D014839:Vomiting / Q000139:chemically induced / Q000517:prevention & control*
D000932:Antiemetics; D018931:Antineoplastic Agents, Hormonal; D017829:Granisetron; D008776:Methylprednisolone Hemisuccinate; D017366:Serotonin Receptor Agonists
Efficacité de l'association granisétron/solumédrol dans le contrôle des nausées et des vomissements aigus chimio-induits. Résultats d'une enquête prospective.