[Prophylactic intra-arterial chemotherapy for CR patients with invasive bladder cancer after induction therapy].
Thirteen patients with invasive bladder cancer treated by induction intra-arterial chemotherapy in combination with radiotherapy achieved a complete response (CR). All of them were treated by prophylactic intra-arterial chemotherapy using pirarubicin (10), epirubicin (2) and carboplatin (1). The treatment was given once a month for 2 years. In the followup period from 14 to 43 months (median; 22.5 months), only one of the 13 patients had an invasive recurrence of bladder cancer and died of it. Ten of the 13 patients are now disease-free and alive with functional bladder. The complications of this therapy were mild and tolerable. The results suggest that prophylactic intra-arterial chemotherapy is a useful regimen for CR patients with invasive bladder cancer after induction therapy.
Sumiyoshi
Y
Y
Dept. of Urology, National Shikoku Cancer Center Hospital.
Hashine
K
K
Kasahara
K
K
D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D018572:Disease-Free Survival; D004317:Doxorubicin / Q000008:administration & dosage / Q000031:analogs & derivatives; D004334:Drug Administration Schedule; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000517:prevention & control*; D012074:Remission Induction; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy* / Q000473:pathology
D015251:Epirubicin; D004317:Doxorubicin; D016190:Carboplatin; C027260:pirarubicin