title: Aspergillosis in immunocompromised children with acute myeloid leukemia and bone marrow aplasia. Report of two cases.
abstract: Two cases of Aspergillosis in immunocompromised children are reported. Both were caused by Aspergillus flavus. Early diagnosis and treatment led to the remission of the process. One patient had acute myeloid leukemia; the fungus was isolated from the blood. The other patient with bone marrow aplasia, presented an invasive aspergillosis of the paranasal sinuses with dissemination of fungal infection; the diagnosis was obtained by histology and culture of biopsied tissue from a palatal ulceration.
authors.affiliation: Centro de Onco-Hematólogia do Instituto da Criança, Hospital das Clínicas de São Paulo, Brasil.
authors.forename: M Z
authors.initials: MZ
authors.lastname: de Aquino
authors.forename: A
authors.initials: A
authors.lastname: Brasciner
authors.forename: L M
authors.initials: LM
authors.lastname: Cristófani
authors.forename: P T
authors.initials: PT
authors.lastname: Maluf
authors.forename: V
authors.initials: V
authors.lastname: Odone Filho
authors.forename: H H
authors.initials: HH
authors.lastname: Marques
authors.forename: E M
authors.initials: EM
authors.lastname: Heins-Vaccari
authors.forename: C da S
authors.initials: Cda S
authors.lastname: Lacaz
authors.forename: N T
authors.initials: NT
authors.lastname: de Melo
mesh_terms: D000293:Adolescent; D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy / Q000276:immunology; D001231:Aspergillus flavus / Q000302:isolation & purification; D001855:Bone Marrow Diseases / Q000150:complications* / Q000276:immunology; D002648:Child; D005260:Female; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000627:therapeutic use; D015470:Leukemia, Myeloid, Acute / Q000150:complications* / Q000276:immunology
chemical_list: D017964:Itraconazole; D000666:Amphotericin B