A solitary plasmacytoma of donor origin arising 14 years after kidney allotransplantation.
Allotransplantation of solid organs transfers passenger leucocytes which may give rise to a state of persistent microchimaerism. In this report we describe the case of a patient who developed a solitary plasmacytoma in a transplanted kidney more than 10 years after allografting. The diagnosis was established on the basis of the presence of a monoclonal IgG kappa peak in the serum, and light chain proteinuria, the plasmacytoid features of tumour cells including cell surface expression of IgG, kappa light chains, CD20, CD38 and CD56, the absence of lytic bone lesions and a normal bone marrow biopsy, and the disappearance of the monoclonal IgG peak after graft nephrectomy. A donor origin of the tumour was established by HLA DNA typing of tumour, tumour-free kidney tissue, and peripheral blood leucocytes, respectively.
Shustik
C
C
Department of Medicine, Royal Victoria Hospital, Montreal, Quebec, Canada.
Jamison
B M
BM
Alfieri
C
C
Scherer
S
S
Loertscher
R
R
D000328:Adult; D006650:Histocompatibility Testing; D006801:Humans; D007680:Kidney Neoplasms / Q000209:etiology*; D016030:Kidney Transplantation; D008297:Male; D010954:Plasmacytoma / Q000209:etiology*; D012150:Polymorphism, Restriction Fragment Length; D013997:Time Factors; D014184:Transplantation, Homologous