title: Nicotine uses and abuses: from brain probe to public health menace.
abstract: There has been a notable lack of dialogue between neuroscientists, who use nicotine in their work as they would any other pharmacological tool, and public policy and health researchers, who view nicotine dependence with increasing dismay and see the continued use of tobacco products as a modern day scourge. This special journal issue attempts to foster communication among nicotine researchers working along the continuum from basic to applied science. An additional objective is to convey a sense for the special problems and opportunities in the study of nicotine and tobacco use that may be of general interest to those concerned with substance abuse. The articles that follow explore two themes, (1) nicotine as a tool to probe neural activity, and (2) tobacco use as a health hazard and societal problem, by examining nicotine from pharmacochemical, biobehavioral, and econo-social perspectives. The rationale for the integration is that there may be benefits from viewing nicotine in a context broader than those dictated by custom and technological specialization.
authors.affiliation: Department of Psychiatry, University of Michigan, Ann Arbor 48105, USA.
authors.forename: O F
authors.initials: OF
authors.lastname: Pomerleau
authors.forename: C S
authors.initials: CS
authors.lastname: Pomerleau
mesh_terms: D000818:Animals; D001143:Arousal / Q000187:drug effects* / Q000502:physiology; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D006801:Humans; D009538:Nicotine / Q000009:adverse effects* / Q000493:pharmacokinetics / Q000494:pharmacology*; D011634:Public Health; D012907:Smoking / Q000009:adverse effects* / Q000503:physiopathology; D016540:Smoking Cessation / Q000523:psychology; D000074606:Smoking Prevention; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology; D014028:Tobacco Smoke Pollution / Q000009:adverse effects* / Q000517:prevention & control
chemical_list: D014028:Tobacco Smoke Pollution; D009538:Nicotine