[Evaluation of bradykinin levels and activation of Tame-esterase in Bronchial alveolar lavage fluid of patients with bronchial asthma].
Airway inflammation is a prominent feature of chronic airway disease as asthma and chronic bronchitis. Multiply cells released mediators and neurotransmitters which are likely to be involved in their origination. The purpose of this study was to establish the levels of kinin, albumin, TAME-esterase activity in BAL fluid of symptomatic and asymptomatic asthmatic patients and to determinate the relationship among mediators. There were significant increases in the mean concentrations of kinin, HSA, TAME-esterase activity in BAL fluid from patients with asthma, chronic bronchitis, compared with the controls (p < 0.005). Kinin mean concentration was in asthmatics 5313, 2 ng/ml, in chronic bronchitis patients 6796.2 ng/ml, versus 468.1 ng/ml in control group. TAME-esterase activity in investigated group was as follow asthmatics 12666 cmp, CB 15131, 3 cmp, versus 3695, 5 cmp in controls. We observed good correlation of kinin and TAME-esterase with HSA in BAL fluid suggest vascular origin of the mediators. The presence of kinins, TAME-esterase in BALs from symptomatic asthmatics and patients with chronic bronchitis provide strong evidence that kinins are involved in this group of lower airway diseases.
Gawlik
R
R
Katedry i Kliniki Chorób Wewnetrznych i Alergologii Slaskiej Akademii Medycznej w Zabrzu.
Baumgarten
C
C
Kunkel
G
G
Rogala
E
E
D000328:Adult; D000418:Albumins / Q000032:analysis; D001249:Asthma / Q000378:metabolism*; D001991:Bronchitis / Q000378:metabolism; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007705:Kinins / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010447:Peptide Hydrolases / Q000032:analysis*
D000418:Albumins; D007705:Kinins; D010447:Peptide Hydrolases; C023073:tosylarginine methyl ester hydrolase
Ocena stezenia bradykininy i aktywności TAME-esterazy w popłuczynach oskrzelowo-pecherzykowych u chorych na astme oskrzelowa.