An examination of the potential "genotoxic" carcinogenicity of a biopesticide derived from the neem tree.
Structural analyses of azadirachtin, a promising biopesticide recently introduced into the United States, indicates that this natural product has the potential for acting as a "genotoxic" carcinogen. In view of the fact that genotoxic carcinogens are regarded as presenting a potential carcinogenic risk to humans, the present finding suggests that the possible metabolism of azadirachtin to DNA-reactive products be evaluated experimentally.
Rosenkranz
H S
HS
Department of Environmental and Occupational Health, University of Pittsburgh, Pennsylvania 15238, USA.
Klopman
G
G
D000818:Animals; D002273:Carcinogens / Q000737:chemistry / Q000633:toxicity*; D016208:Databases, Factual; D007306:Insecticides / Q000737:chemistry / Q000633:toxicity*; D036701:Limonins; D051379:Mice; D015394:Molecular Structure; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry / Q000633:toxicity*; D012377:Rodentia; D012984:Software; D013329:Structure-Activity Relationship; D014197:Trees; D014315:Triterpenes / Q000737:chemistry / Q000633:toxicity*; D014481:United States
D002273:Carcinogens; D007306:Insecticides; D036701:Limonins; D009153:Mutagens; D014315:Triterpenes; C010329:azadirachtin