IL-6 and G-CSF levels in amniotic fluid during the second trimester in normal and abnormal pregnancies.
Activity levels of cytokines were measured by stimulation of the cell lines NFS-60, 7TD1, and TF-1. In 39 samples of amniotic fluid, levels of Granulocyte-Stimulating Factor (G-CSF) were 1434 +/- 2063 (mean +/- SD) and of Interleukin (IL-6) 546 +/- 1071 pg/ml; Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was not detectable. IL-6 was correlated to G-CSF (r = 0.3; p = 0.003). G-CSF (p = 0.0002) and IL-6 (p = 0.006) were influenced by Alpha-Fetoprotein (AFP) and G-CSF by rhesus-incompatibility (p = 0.0004). These findings suggest that cytokines such as IL-6 and G-CSF play some role in physiological and pathological pregnancy.
Weimann
E
E
Children's Hospital, University of Frankfurt/Main, Germany.
Reisbach
G
G
Reinsberg
J
J
Lentze
M J
MJ
D000328:Adult; D000653:Amniotic Fluid / Q000276:immunology*; D002181:Candidiasis, Vulvovaginal / Q000276:immunology; D005260:Female; D016179:Granulocyte Colony-Stimulating Factor / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D015850:Interleukin-6 / Q000378:metabolism*; D011247:Pregnancy; D011248:Pregnancy Complications / Q000276:immunology*; D011262:Pregnancy Trimester, Second; D011272:Pregnancy, Multiple / Q000276:immunology; D012016:Reference Values; D012203:Rh Isoimmunization / Q000276:immunology; D000509:alpha-Fetoproteins / Q000378:metabolism
D015850:Interleukin-6; D000509:alpha-Fetoproteins; D016179:Granulocyte Colony-Stimulating Factor