Measurement of glomerular filtration rate by single-injection, single-sample techniques, using 51Cr-EDTA or iohexol.
Clearance calculations based on single sample determinations from 51Cr-EDTA samples 180 min after giving radioisotope showed a correlation coefficient of 0.992 to clearance calculations after multiple sampling of 51Cr-EDTA. The range of clearance determinations in 108 patients varied from 4 to 141 ml/min, 1.73 m2 BA. Twenty patients had clearance values below 20 ml/min, 1.73 m2 BA. Clearance calculations from single samples of iohexol from 180 min values showed a correlation coefficient of 0.986 to clearance calculations after multiple sampling of 51Cr-EDTA. These calculations were based on samples from 122 patients with clearance values varying from 4 to 139 ml/min, 1.73 m2 BA. No adverse reactions were registered during the study. This study confirms the reliability of single sample methods for clearance calculations at all levels of renal function.
Rydström
M
M
Department of Clinical Chemistry, County Central Hospital, Skövde, Sweden.
Tengström
B
B
Cederquist
I
I
Ahlmén
J
J
D000328:Adult; D002860:Chromium Radioisotopes; D003287:Contrast Media; D004492:Edetic Acid; D005260:Female; D015902:Gamma Cameras; D005919:Glomerular Filtration Rate / Q000502:physiology*; D006801:Humans; D007472:Iohexol; D007676:Kidney Failure, Chronic / Q000097:blood / Q000175:diagnosis*; D008297:Male; D012016:Reference Values; D015203:Reproducibility of Results
D002860:Chromium Radioisotopes; D003287:Contrast Media; D007472:Iohexol; D004492:Edetic Acid