title: Stimulation of the globus pallidus in Parkinson's disease.
abstract: In 62 patients undergoing posteroventral pallidotomy (PVP) for the treatment of Parkinson's disease, we have demonstrated significant (p < 0.01) elimination of akinetic features and other symptoms during intraoperative stimulation trials in areas anterior to the PVP target (n = 30). Stimulation in anterior pallidal regions frequently resulted in an immediate reversal of akinetic states despite enforced abstinence of medications. The beneficial effects were achieved with as little as 0.25 V at 100 Hz. Stimulation at the PVP target site (n = 32) resulted in insignificant changes (p > 0.05).
authors.affiliation: Division of Neurosurgery, Loma Linda University Medical Center, CA 92350, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Iacono
authors.forename: R R
authors.initials: RR
authors.lastname: Lonser
authors.forename: G
authors.initials: G
authors.lastname: Mandybur
authors.forename: S
authors.initials: S
authors.lastname: Yamada
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001931:Brain Mapping; D004298:Dopamine / Q000502:physiology; D004558:Electric Stimulation; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000502:physiology; D009433:Neural Inhibition / Q000502:physiology; D010300:Parkinson Disease / Q000503:physiopathology* / Q000601:surgery; D013787:Thalamic Nuclei / Q000503:physiopathology
chemical_list: D004298:Dopamine