Coefficient of distribution of some organophosphorous pesticides in rat tissue.
Coefficient of distribution in tissue is proposed as an indicator of the affinity of xenobiotics for different tissues and their tendency to accumulate. The present study shows the distribution of some organophosphorous pesticides in rat tissues. Using the coefficient of distribution we established the preference of these insecticides for the various tissues. Each pesticide had a specific pattern of affinity for different tissues.
Garcia-Repetto
R
R
Instituto Nacional de Toxicologia, Sevilla, Spain.
Martinez
D
D
Repetto
M
M
D000273:Adipose Tissue / Q000378:metabolism; D000818:Animals; D001921:Brain / Q000378:metabolism; D003627:Data Interpretation, Statistical; D003976:Diazinon / Q000008:administration & dosage / Q000493:pharmacokinetics; D004117:Dimethoate / Q000008:administration & dosage / Q000493:pharmacokinetics; D007306:Insecticides / Q000008:administration & dosage / Q000493:pharmacokinetics*; D007928:Lethal Dose 50; D008099:Liver / Q000378:metabolism; D008297:Male; D008743:Methyl Parathion / Q000008:administration & dosage / Q000493:pharmacokinetics; D009132:Muscles / Q000378:metabolism; D010261:Paraoxon / Q000008:administration & dosage / Q000493:pharmacokinetics; D010278:Parathion / Q000008:administration & dosage / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution
D007306:Insecticides; D008743:Methyl Parathion; D010278:Parathion; D010261:Paraoxon; D004117:Dimethoate; D003976:Diazinon