title: Extracorporeal membrane oxygenation as an adjunct treatment for primary graft failure in adult lung transplant recipients.
abstract: Primary graft failure is a catastrophic event in lung transplantation. Failure is characterized by profound abnormalities of gas exchange that are frequently unresponsive to alterations in mechanical ventilation. This condition can be fatal and, if less severe, is usually associated with significant permanent damage to the allograft. We report the use of extracorporeal membrane oxygenation as a means to support lung transplant recipients with severe graft failure. Since 1991, extracorporeal membrane oxygenation has been used on 17 occasions for the temporary support of 16 adult lung transplant recipients. All patients met or exceeded standard National Institutes of Health guidelines for institution of extracorporeal membrane oxygenation. Nine double lung, six single lung, and one heart-lung recipients were supported for 1 to 12 days (mean 4.6 +/- 2.2 days). Extracorporeal membrane oxygenation was instituted early, within 7 days of transplantation, in ten patients. Eight early patients (80%) were successfully weaned from extracorporeal membrane oxygenation. Seven of ten (70%) patients were long-term survivors, and five of the seven had normal lung function. In comparison, there were no survivors among six recipients placed on extracorporeal membrane oxygenation for late (> or = 7 days) graft dysfunction. Extracorporeal membrane oxygenation is a lifesaving adjunct in recipients with acute graft failure after lung transplantation. Ischemia-reperfusion injury and acute graft dysfunction after lung transplantation can be successfully reversed with early aggressive intervention.
authors.affiliation: Department of Cardiac and Thoracic Surgery, University of Pittsburgh Medical Center, Pa., USA.
authors.forename: L R
authors.initials: LR
authors.lastname: Glassman
authors.forename: R J
authors.initials: RJ
authors.lastname: Keenan
authors.forename: M C
authors.initials: MC
authors.lastname: Fabrizio
authors.forename: J R
authors.initials: JR
authors.lastname: Sonett
authors.forename: M I
authors.initials: MI
authors.lastname: Bierman
authors.forename: S M
authors.initials: SM
authors.lastname: Pham
authors.forename: B P
authors.initials: BP
authors.lastname: Griffith
mesh_terms: D000328:Adult; D015199:Extracorporeal Membrane Oxygenation; D006085:Graft Survival; D006801:Humans; D016040:Lung Transplantation / Q000009:adverse effects*; D015427:Reperfusion Injury / Q000628:therapy; D012131:Respiratory Insufficiency / Q000209:etiology / Q000628:therapy*