title: Synthesis and antimalarial activities of several fluorinated artemisinin derivatives.
abstract: The carbonyl groups in several artemisinin derivatives were converted into geminal difluorinated compounds on treatment with diethylaminosulfur trifluoride. A number of other mono- and polyfluorinated artemisinin derivatives were prepared. Their in vitro antimalarial activities were all equal to or greater than the nonfluorinated analogs or precursors.
authors.affiliation: Laboratory of Chemical Physics, NIDDK, Bethesda, Maryland 20892-0510, USA.
authors.forename: Y M
authors.initials: YM
authors.lastname: Pu
authors.forename: D S
authors.initials: DS
authors.lastname: Torok
authors.forename: H
authors.initials: H
authors.lastname: Ziffer
authors.forename: X Q
authors.initials: XQ
authors.lastname: Pan
authors.forename: S R
authors.initials: SR
authors.lastname: Meshnick
mesh_terms: D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D037621:Artemisinins; D005461:Fluorine; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D012717:Sesquiterpenes; D005461:Fluorine; C031327:artemisinin