The anatomy of a molecular giant: how the sarcomere cytoskeleton is assembled from immunoglobulin superfamily molecules.
Cross-striated muscle contains an elastic cytoskeleton comprised of the giant protein titin and several associated proteins. cDNA sequencing revealed that all these proteins are immunoglobulin superfamily members. This modular structure opens the possibility to dissect the proteins involved into functional units and to approach the problem of structure-function correlation at the molecular level.
Fürst
D O
DO
Max-Planck-Institute for Biophysical Chemistry, Göttingen, Germany.
Gautel
M
M
D000818:Animals; D002352:Carrier Proteins / Q000737:chemistry / Q000378:metabolism; D002642:Chick Embryo; D064211:Connectin; D003599:Cytoskeleton / Q000737:chemistry* / Q000378:metabolism; D005353:Fibronectins / Q000235:genetics; D006801:Humans; D007136:Immunoglobulins / Q000235:genetics; D051379:Mice; D009024:Morphogenesis; D009124:Muscle Proteins / Q000737:chemistry / Q000276:immunology / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D018482:Muscle, Skeletal / Q000196:embryology; D009157:Myasthenia Gravis / Q000276:immunology; D009219:Myosin-Light-Chain Kinase / Q000235:genetics; D011494:Protein Kinases / Q000737:chemistry / Q000276:immunology / Q000502:physiology* / Q000648:ultrastructure; D012208:Rhabdomyosarcoma / Q000175:diagnosis; D012518:Sarcomeres / Q000737:chemistry*
D002352:Carrier Proteins; D064211:Connectin; D005353:Fibronectins; D007136:Immunoglobulins; D009124:Muscle Proteins; C577285:TTN protein, human; D011494:Protein Kinases; D009219:Myosin-Light-Chain Kinase