title: Sequence diversity and unusual variability at the het-c locus involved in vegetative incompatibility in the fungus Podospora anserina.
abstract: The het-c locus of the filamentous fungus Podospora anserina controls heterokaryon formation through genetic interaction with alleles of the unlinked loci het-e and het-d. We have isolated four wild-type and two mutant alleles of the het-c locus. A comparison of the predicted proteins encoded by the different wild-type alleles revealed an unusual high level of amino-acid replacements compared to silent polymorphisms but only one amino-acid difference is sufficient to modify the specificity of het-c alleles. Chimeric genes constructed in vitro may exhibit a new specificity different from that of any known wild-type allele.
authors.affiliation: Laboratoire de Génétique, UPR CNRS 9026, Université de Bordeaux II, Talence, France.
authors.forename: S
authors.initials: S
authors.lastname: Saupe
authors.forename: B
authors.initials: B
authors.lastname: Turcq
authors.forename: J
authors.initials: J
authors.lastname: Bégueret
mesh_terms: D000483:Alleles; D000595:Amino Acid Sequence; D000596:Amino Acids / Q000235:genetics; D001203:Ascomycota / Q000235:genetics* / Q000502:physiology; D001483:Base Sequence; D002678:Chimera; D003001:Cloning, Molecular; D005656:Fungal Proteins / Q000737:chemistry / Q000235:genetics*; D015966:Gene Expression Regulation, Fungal; D014644:Genetic Variation; D008969:Molecular Sequence Data; D009154:Mutation; D011110:Polymorphism, Genetic; D012333:RNA, Messenger; D011995:Recombination, Genetic; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid
chemical_list: D000596:Amino Acids; D005656:Fungal Proteins; D012333:RNA, Messenger