title: The hedgehog gene family in Drosophila and vertebrate development.
abstract: The segment polarity gene hedgehog plays a central role in cell patterning during embryonic and post-embryonic development of the dipteran, Drosophila melanogaster. Recent studies have identified a family of hedgehog related genes in vertebrates; one of these, Sonic hedgehog is implicated in positional signalling processes that show interesting similarities with those controlled by its Drosophila homologue.
authors.affiliation: Molecular Embryology Laboratory, ICRF Developmental Biology Unit, Department of Zoology, Oxford, UK.
authors.forename: M J
authors.initials: MJ
authors.lastname: Fietz
authors.forename: J P
authors.initials: JP
authors.lastname: Concordet
authors.forename: R
authors.initials: R
authors.lastname: Barbosa
authors.forename: R
authors.initials: R
authors.lastname: Johnson
authors.forename: S
authors.initials: S
authors.lastname: Krauss
authors.forename: A P
authors.initials: AP
authors.lastname: McMahon
authors.forename: C
authors.initials: C
authors.lastname: Tabin
authors.forename: P W
authors.initials: PW
authors.lastname: Ingham
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002642:Chick Embryo; D004330:Drosophila / Q000196:embryology / Q000235:genetics / Q000254:growth & development*; D029721:Drosophila Proteins; D004627:Embryonic Induction / Q000235:genetics; D005121:Extremities / Q000196:embryology; D015870:Gene Expression; D017344:Genes, Insect; D053823:Hedgehog Proteins; D051379:Mice; D008969:Molecular Sequence Data; D009024:Morphogenesis / Q000235:genetics; D011506:Proteins / Q000235:genetics*; D016415:Sequence Alignment; D014714:Vertebrates / Q000196:embryology / Q000235:genetics / Q000254:growth & development*
chemical_list: D029721:Drosophila Proteins; D053823:Hedgehog Proteins; D011506:Proteins; C077245:hh protein, Drosophila