[Correlative study of erythrocyte membrane insulin receptor with blood lipids and albumin in non-obese noninsulin-dependent diabetics (NIDDM) patients before and after exercise].
To understand the effects of the levels of blood lipids and albumin on insulin receptor binding before and after acute exercise, we measured insulin binding to erythrocyt membrane before and after 30 minutes moderate exercise in thirty-eight non-obese noninsulin-dependent diabetics (NIDDM) and thirty-seven normal subjects. The correlations between parameters of insulin receptor and blood lipids and albumin were also studied. The results showed that before acute exercise, the level of high-binding-affinity (K1) was significantly correlated with that of total cholesterol (r = -0.473, P = 0.013), and albumin (r = -0.483, P = 0.011). The low-binding-affinity (K2) was significantly correlated with that of triglycerides (r = 0.503, P = 0.008) and high-density-lipoprotein (HDL) cholesterol (r = -0.480, P = 0.011). After acute exercise, no significant correlations between the parameters of insulin receptor, blood lipids and albumin were found. These suggest that blood lipids and albumin are important influential factors for affinities of insulin receptor.
Zhang
S
S
Third Department of Internal Medicine, 202nd Hospital of PLA, Shenyang.
Wang
J
J
Quan
B
B
D000328:Adult; D002784:Cholesterol / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D004910:Erythrocyte Membrane / Q000378:metabolism*; D005080:Exercise Test; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011972:Receptor, Insulin / Q000378:metabolism*; D012709:Serum Albumin / Q000378:metabolism*; D014280:Triglycerides / Q000097:blood
D012709:Serum Albumin; D014280:Triglycerides; D002784:Cholesterol; D011972:Receptor, Insulin