Transmission blocking immunity as observed in a feeder system and serological reactivity to Pfs 48/45 and Pfs230 in field sera.
Monoclonal antibodies (mAbs) and human sera from gametocyte carriers were applied in the bio-assay to test for their transmission-blocking capacity. Competition ELISA's have been developed for the detection of natural transmission blocking antibodies. Approximately 55% of the sera blocking in the bio-assay gave positive results in these competition ELISA's.
Roeffen
W
W
University of Nijmegen, Department of Medical Microbiology, The Netherlands.
Lensen
T
T
Mulder
B
B
Teelen
K
K
Sauerwein
R
R
Eling
W
W
Meuwissen
J H
JH
Beckers
P
P
D000328:Adult; D000913:Antibodies, Protozoan / Q000276:immunology*; D000954:Antigens, Surface / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods*; D006801:Humans; D007106:Immune Sera / Q000276:immunology*; D016778:Malaria, Falciparum / Q000276:immunology*
D000913:Antibodies, Protozoan; D000954:Antigens, Surface; D007106:Immune Sera