Cognitive functioning in experimental hypoglycaemia assessed with event-related potentials.
Cognitive effects of experimentally induced hypoglycaemia were investigated by event-related brain potentials (ERPs) in auditory and visual classification tasks. In a cross-over design eight healthy male subjects (age 22-27 years) were studied under control conditions or following administration of 0.15 IU insulin kg-1. The ERPs showed preserved early cortical components, while the N2 component was greatly reduced in both modalities. P3 components did not show an influence of hypoglycemia. These results suggest that the cognitive deficits are due to an impairment of automatic feature extraction from the stimuli.
Münte
T F
TF
Department of Neurology, Medical School Hannover, Germany.
Berger
D
D
Terkamp
C
C
Schöfl
C
C
Johannes
S
S
Brabant
G
G
D000328:Adult; D003072:Cognition Disorders / Q000139:chemically induced / Q000503:physiopathology*; D018592:Cross-Over Studies; D005069:Evaluation Studies as Topic; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D005074:Evoked Potentials, Visual / Q000502:physiology*; D006801:Humans; D007003:Hypoglycemia / Q000139:chemically induced / Q000523:psychology*; D007328:Insulin; D008297:Male; D012016:Reference Values
D007328:Insulin