title: Calcitonin gene-related peptide and peripherin immunoreactivity in nerve sheaths.
abstract: The intrinsic innervation of rat sciatic nerve sheaths was studied by means of immunohistochemical labeling for calcitonin gene-related peptide (CGRP) and peripherin. CGRP immunoreactivity (CGRP-IR) and peripherin immunoreactivity (peripherin-IR) were found in fine nerve fibers independent of nerve sheath vasculature. These findings suggest that a subset of the nervi nervorum may have nociceptive functions, and that this subset is distinct from nerve fibers that innervate the blood vessels of the nerve sheaths.
authors.affiliation: Department of Cell Biology and Anatomy, University of North Carolina at Chapel Hill 27599, USA.
authors.forename: G M
authors.initials: GM
authors.lastname: Bove
authors.forename: A R
authors.initials: AR
authors.lastname: Light
mesh_terms: D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000502:physiology*; D002196:Capillaries / Q000294:innervation; D002415:Cats; D005260:Female; D007124:Immunoenzyme Techniques; D007381:Intermediate Filament Proteins / Q000502:physiology*; D008297:Male; D008562:Membrane Glycoproteins; D009412:Nerve Fibers / Q000502:physiology* / Q000648:ultrastructure; D009419:Nerve Tissue Proteins; D009479:Neuropeptides / Q000502:physiology*; D009619:Nociceptors / Q000033:anatomy & histology / Q000502:physiology*; D010525:Peripheral Nerves / Q000033:anatomy & histology / Q000502:physiology*; D064531:Peripherins; D051381:Rats; D012584:Sciatic Nerve / Q000033:anatomy & histology / Q000502:physiology; D009435:Synaptic Transmission / Q000502:physiology*; D014650:Vasa Nervorum / Q000033:anatomy & histology / Q000502:physiology
chemical_list: D007381:Intermediate Filament Proteins; D008562:Membrane Glycoproteins; D009419:Nerve Tissue Proteins; D009479:Neuropeptides; D064531:Peripherins; D015740:Calcitonin Gene-Related Peptide