Partitioning of total pulmonary resistance in horses.
The partitioning of total pulmonary resistance (RL) into upper airway resistance and lower airway resistance (RI) was studied in 8 Thoroughbred geldings. In addition, the phase shift and amplitude distortion of 3 catheters used for pressure measurements in this study were evaluated under static and dynamic conditions. Flow rate was obtained from a heated pneumotachograph attached to a tight-fitting mask placed over the nose. Electronic integration of the flow signal gave tidal volume. Transpulmonary pressure (PL) was obtained from calculation of the difference between the esophageal balloon catheter pressure and mask pressure. Lateral tracheal pressure was measured from a polyethylene catheter placed percutaneously in the middle portion of the trachea. Lower airway pressure (PI) was calculated as the difference between esophageal pressure and lateral tracheal pressure. Similarly, upper airway pressure was defined as the difference between lateral tracheal pressure and mask pressure. Pressures are reported as the difference between the maximal and the minimal pressures recorded during a respiratory cycle. Airway resistance was calculated, using the isovolume method, at 50% of tidal volume. There were individual and group variations in Pi and Pl/PL, although Pi accounted for more than 60% of PL in all horses. In 6 horses, Rl was more than 50% of RL whereas in 2 horses, Rl was only 30 and 34% of RL. Amplitude distortion was minimal for the 3 catheters under static conditions in the in vitro study. Under dynamic conditions, amplitude distortion varied according to the catheter studied, the frequency, and the resistance of the system.(ABSTRACT TRUNCATED AT 250 WORDS)
Lavoie
J P
JP
Département de Sciences Cliniques, Faculté de Médecine Vétérinaire, Université de Montréal, St Hyacinthe, Quebec, Canda.
Pascoe
J R
JR
Kupershoek
C J
CJ
D000403:Airway Resistance / Q000502:physiology*; D000818:Animals; D006736:Horses / Q000502:physiology*; D008168:Lung / Q000502:physiology*; D008297:Male; D009919:Orchiectomy; D011312:Pressure; D012119:Respiration; D013990:Tidal Volume