title: Characteristics of blood hemostatic markers in a patient with ovarian hyperstimulation syndrome who actually developed thromboembolism.
abstract: OBJECTIVE
  To investigate whether a patient with ovarian hyperstimulation syndrome (OHSS) demonstrated characteristic changes in the blood hemostatic markers before she developed thromboembolism.
  
  
  METHODS
  Patients with OHSS had blood drawn to determine hemostatic markers and related factors.
  
  
  METHODS
  Twenty-three OHSS patients, including a case complicated with thromboembolism.
  
  
  METHODS
  The IVF-ET program of the Department of Obstetrics and Gynecology, The University of Akita, School of Medicine.
  
  
  METHODS
  Blood hemostatic markers and related factors.
  
  
  RESULTS
  The patient with thromboembolism demonstrated marked leukocytosis and higher levels of activation in the blood markers related to fibrinolytic system, such as alpha 2 plasmin inhibitor, plasmin-alpha 2 antiplasmin complexes, and D-dimers, before the onset of this episode.
  
  
  CONCLUSIONS
  Marked leukocytosis and higher levels of activation of the fibrinolytic system may be the signs of imminent thromboembolism in OHSS patients.
authors.affiliation: Department of Obstetrics and Gynecology, Akita University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kodama
authors.forename: J
authors.initials: J
authors.lastname: Fukuda
authors.forename: H
authors.initials: H
authors.lastname: Karube
authors.forename: T
authors.initials: T
authors.lastname: Matsui
authors.forename: Y
authors.initials: Y
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000097:blood*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005341:Fibrinolysin / Q000032:analysis / Q000378:metabolism; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D007964:Leukocytosis; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood / Q000150:complications*; D010062:Ovulation Induction / Q000009:adverse effects; D013923:Thromboembolism / Q000097:blood* / Q000209:etiology; D000979:alpha-2-Antiplasmin / Q000032:analysis / Q000378:metabolism
chemical_list: D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D000979:alpha-2-Antiplasmin; C036309:fibrin fragment D; D005341:Fibrinolysin