Toxicity of cotoran (fluometuron) in Desert sheep.
Twelve of fifteen 6-9-mo-old clinically healthy Desert sheep were given single or repeated daily doses of 25 to 4000 mg cotoran/kg by drench. Cotoran poisoning was characterized by grinding of the teeth, ruminal tympany, mydriasis, dyspnea, staggering, paresis of the hind and forelimbs, and recumbency. Lesions were widespread congestion and hemorrhage, hepatic fatty change, catarrhal enteritis and degeneration of the epithelial cells of the renal proximal convoluted tubules. These were accompanied by significant increases in the activities of GOT, LDH and GGT and decreases in serum total protein and calcium.
Mohamed
O S
OS
Veterinary Research Administration, Khartoum, Sudan.
Ahmed
K E
KE
Adam
S E
SE
Idris
O F
OF
D000018:Abomasum / Q000187:drug effects / Q000473:pathology; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001921:Brain / Q000187:drug effects / Q000473:pathology; D006321:Heart / Q000187:drug effects; D006540:Herbicides / Q000633:toxicity*; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000473:pathology; D008168:Lung / Q000187:drug effects / Q000473:pathology; D008297:Male; D008782:Methylurea Compounds / Q000633:toxicity*; D017933:Peripheral Nervous System / Q000187:drug effects / Q000473:pathology; D012756:Sheep; D012757:Sheep Diseases / Q000139:chemically induced* / Q000473:pathology; D012989:Soil Pollutants / Q000633:toxicity*; D013116:Spinal Cord / Q000187:drug effects / Q000473:pathology; D013154:Spleen / Q000187:drug effects / Q000473:pathology; D014018:Tissue Distribution; D014132:Trachea / Q000187:drug effects / Q000473:pathology; D014874:Water Pollutants, Chemical / Q000633:toxicity*
D015415:Biomarkers; D006540:Herbicides; D008782:Methylurea Compounds; D012989:Soil Pollutants; D014874:Water Pollutants, Chemical; C005015:fluometuron