title: The influence of an PGF2x analogue and of some peptidoleukotrienes and platelet activating factor antagonists in experimentally induced gastric ulcer in rats.
abstract: We tested the influence of 30 mg/kg/per os BN 52021, 300 micrograms/kg Cloprostenol (CIPG) and of 5 mg/kg per os LY 171883B in stress restrain and indomethacin induced ulcers in rats. The data obtained show that CIPG and LY 171883 have a significant gastroprotective action in both ulcer models. BN 52021 has a significant protective activity in stress ulcer and less in indomethacin-induced ulcers.
authors.affiliation: Dept. Pharmacology, Univ. Med. Pharm., IASI, Romania.
authors.forename: M
authors.initials: M
authors.lastname: Nechifor
authors.forename: I B
authors.initials: IB
authors.lastname: Neughebauer
authors.forename: M
authors.initials: M
authors.lastname: Costuleanu
authors.forename: M
authors.initials: M
authors.lastname: Alomnicăi
authors.forename: E
authors.initials: E
authors.lastname: Teslaru
authors.forename: C
authors.initials: C
authors.lastname: Filip
authors.forename: F
authors.initials: F
authors.lastname: Cocu
mesh_terms: D000098:Acetophenones / Q000494:pharmacology*; D000818:Animals; D003008:Cloprostenol / Q000494:pharmacology*; D015237:Dinoprost / Q000031:analogs & derivatives; D004224:Diterpenes; D046934:Ginkgolides; D007213:Indomethacin; D007783:Lactones / Q000494:pharmacology*; D015289:Leukotrienes / Q000494:pharmacology; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications; D013777:Tetrazoles / Q000494:pharmacology*
chemical_list: D000098:Acetophenones; D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D015289:Leukotrienes; D010972:Platelet Activating Factor; D013777:Tetrazoles; D003008:Cloprostenol; C044660:LY 171883; D015237:Dinoprost; C045856:ginkgolide B; D007213:Indomethacin