[Appearance in 2 brothers of double primary neoplasms: right renal carcinoma and gastric adenocarcinoma].
We report a clinical case of a double primitive tumour (right kidney clear cell carcinoma and gastric carcinoma) in two brothers. There is no history of cancer in the parents. Both patients were previously affected by gastric ulcer. No report of association between the two neoplasms was found in literature. The age of the patients (61 and 70 years) and the singleness of the kidney tumour seem to exclude the case of a familial kidney cancer. The neoplastic transformation of the gastric ulcer is instead a quite frequent report with an incidence of about 1%. Alterations of oncogenes or tumour suppressor genes shared from both neoplasm are at present still unknown. Nevertheless molecular analysis of patients' neoplastic genome could point out typical chromosome translocations/deletions or gene mutations.
Casetta
G
G
Università degli Studi, Torino Cattedra di Patologia Urologica.
Piana
P
P
Gamba
P
P
Gontero
P
P
Bodo
G
G
Lauro
D
D
Calderini
P
P
D000230:Adenocarcinoma / Q000209:etiology / Q000235:genetics; D018262:Adenocarcinoma, Clear Cell / Q000235:genetics; D000368:Aged; D002869:Chromosome Aberrations; D016147:Genes, Tumor Suppressor; D006801:Humans; D007680:Kidney Neoplasms / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000235:genetics; D009679:Nuclear Family; D013274:Stomach Neoplasms / Q000209:etiology / Q000235:genetics; D013276:Stomach Ulcer / Q000150:complications
Comparsa in due fratelli di duplice neoplasia primitiva: carcinoma renale destro ed adenocarcinoma gastrico.