Expression profile of Ldh-a in the developing rat (Rattus norvegicus) testis suggests regulation at the translational level.
Expression of Ldh-a and Ldh-c mRNAs was examined in the rat testis. The mRNA levels of both Ldh-a and Ldh-c increase during testicular maturation. In the adult testis, Ldh-a mRNA is expressed maximally in primary spermatocytes. Comparison of the Ldh-a mRNA expression profile with its translation product suggests that this gene is translationally down-regulated during spermatogenesis.
Salehi-Ashtiani
K
K
Northwestern University, Department of Biochemistry, Evanston, IL 60208, USA.
Goldberg
E
E
D000818:Animals; D015536:Down-Regulation; D018507:Gene Expression Regulation, Developmental; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000235:genetics*; D008297:Male; D014176:Protein Biosynthesis; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013090:Spermatocytes / Q000201:enzymology; D013091:Spermatogenesis / Q000235:genetics / Q000502:physiology; D013737:Testis / Q000201:enzymology* / Q000254:growth & development
D007527:Isoenzymes; D012333:RNA, Messenger; D007770:L-Lactate Dehydrogenase