Fever and the acute elevation in whole-body thermogenesis induced by lateral hypothalamic lesions.
Three studies investigated the role of fever in the acute elevation of heat production induced by lateral hypothalamic (LH) lesions and the mechanisms by which this thermogenic response can be attenuated by reductions in body weight. In Study 1, reducing the weights of rats prior to lesioning the LH attenuated both the usual postlesion fever and elevation in thermogenesis. In Study 2, blocking prostaglandin synthesis with indomethacin likewise blunted both the lesion-induced fever and thermogenesis. In Study 3, treating already weight-reduced rats with indomethacin attenuated, but still failed to eliminate, the lesion-induced fever. Together, these results suggest that both the fever and increased thermogenesis induced by LH lesions are mediated, at least in part, by prostaglandin mechanisms which themselves are influenced by body energy status.
Lennie
T A
TA
School of Nursing, University of Wisconsin, Madison 53792, USA.
Hirvonen
M D
MD
McCarthy
D O
DO
Keesey
R E
RE
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001833:Body Temperature Regulation / Q000187:drug effects / Q000502:physiology*; D001835:Body Weight / Q000187:drug effects / Q000502:physiology; D004734:Energy Metabolism / Q000502:physiology; D005334:Fever / Q000503:physiopathology*; D007033:Hypothalamus, Middle / Q000502:physiology*; D007213:Indomethacin / Q000494:pharmacology; D008297:Male; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D011448:Prostaglandin Antagonists / Q000494:pharmacology; D011453:Prostaglandins / Q000096:biosynthesis; D051381:Rats; D017207:Rats, Sprague-Dawley; D014697:Ventromedial Hypothalamic Nucleus / Q000502:physiology
D000894:Anti-Inflammatory Agents, Non-Steroidal; D011448:Prostaglandin Antagonists; D011453:Prostaglandins; D007213:Indomethacin