title: Pyridoxine for nausea and vomiting of pregnancy: a randomized, double-blind, placebo-controlled trial.
abstract: OBJECTIVE
  Our purpose was to determine the effectiveness of pyridoxine for nausea and vomiting of pregnancy.
  
  
  METHODS
  During an 11-month period 342 women who first attended Chiang Mai University Hospital antenatal clinic at < or = 17 weeks' gestation were randomized to received either oral pyridoxine hydrochloride, 30 mg per day, or placebo in a double-blind fashion. Patients graded the severity of their nausea by a visual analog scale and recorded the number of vomiting episodes over the previous 24 hours before treatment and again during 5 consecutive days on treatment.
  
  
  RESULTS
  There was a significant decrease in the mean of posttherapy minus baseline nausea scores in the pyridoxine compared with that in the placebo group (t test, p = 0.0008). There was also a greater reduction in the mean number of vomiting episodes, but the differences did not reach statistical significance (p = 0.0552).
  
  
  CONCLUSIONS
  Pyridoxine is effective in relieving the severity of nausea in early pregnancy.
authors.affiliation: Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Thailand.
authors.forename: T
authors.initials: T
authors.lastname: Vutyavanich
authors.forename: S
authors.initials: S
authors.lastname: Wongtra-ngan
authors.forename: R
authors.initials: R
authors.lastname: Ruangsri
mesh_terms: D000328:Adult; D000932:Antiemetics / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D009325:Nausea / Q000188:drug therapy*; D010919:Placebos; D011247:Pregnancy; D011248:Pregnancy Complications / Q000188:drug therapy*; D011736:Pyridoxine / Q000627:therapeutic use*; D014839:Vomiting / Q000188:drug therapy*
chemical_list: D000932:Antiemetics; D010919:Placebos; D011736:Pyridoxine