Anti-human gonadotropin antibodies generated during in vitro fertilization (IVF)-related cycles: effect on fertility of rhesus macaques.
Administration of human gonadotropins such as hFSH, hLH, and hCG to rhesus macaques can result in formation of anti-human gonadotropin antibodies. To determine whether the presence of these antibodies interferes with subsequent fertility, sixteen female rhesus macaques (Macaca mulatta) with known antibody levels were bred with male rhesus macaques. The presence of antibodies did not interfere with conception or maintenance of pregnancy. Furthermore, antibody titers did not increase during gestation or following the resolution of pregnancy.
Iliff
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Division of Primate Medicine, Oregon Regional Primate Research Center, Beaverton 97006, USA.
Molskness
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TA
Stouffer
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D000818:Animals; D000917:Antibody Formation; D006063:Chorionic Gonadotropin / Q000276:immunology* / Q000494:pharmacology; D005260:Female; D005298:Fertility / Q000276:immunology*; D005300:Fertility Agents, Female / Q000276:immunology* / Q000494:pharmacology; D005307:Fertilization in Vitro / Q000662:veterinary*; D005640:Follicle Stimulating Hormone / Q000276:immunology* / Q000494:pharmacology; D006801:Humans; D007986:Luteinizing Hormone / Q000276:immunology* / Q000494:pharmacology; D008253:Macaca mulatta; D008297:Male; D006080:Ovarian Follicle / Q000187:drug effects / Q000502:physiology; D011247:Pregnancy; D011270:Pregnancy, Animal / Q000276:immunology*; D012016:Reference Values
D006063:Chorionic Gonadotropin; D005300:Fertility Agents, Female; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone