title: Magnetic resonance elastography by direct visualization of propagating acoustic strain waves.
abstract: A nuclear magnetic resonance imaging (MRI) method is presented for quantitatively mapping the physical response of a material to harmonic mechanical excitation. The resulting images allow calculation of regional mechanical properties. Measurements of shear modulus obtained with the MRI technique in gel materials correlate with independent measurements of static shear modulus. The results indicate that displacement patterns corresponding to cyclic displacements smaller than 200 nanometers can be measured. The findings suggest the feasibility of a medical imaging technique for delineating elasticity and other mechanical properties of tissue.
authors.affiliation: Mayo Clinic and Foundation, Rochester, MN 55905, USA.
authors.forename: R
authors.initials: R
authors.lastname: Muthupillai
authors.forename: D J
authors.initials: DJ
authors.lastname: Lomas
authors.forename: P J
authors.initials: PJ
authors.lastname: Rossman
authors.forename: J F
authors.initials: JF
authors.lastname: Greenleaf
authors.forename: A
authors.initials: A
authors.lastname: Manduca
authors.forename: R L
authors.initials: RL
authors.lastname: Ehman
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D001696:Biomechanical Phenomena; D004548:Elasticity; D005782:Gels; D007668:Kidney / Q000033:anatomy & histology* / Q000502:physiology; D007672:Kidney Cortex / Q000033:anatomy & histology / Q000502:physiology; D007679:Kidney Medulla / Q000033:anatomy & histology / Q000502:physiology; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009682:Magnetic Resonance Spectroscopy; D008433:Mathematics; D051379:Mice; D012685:Sepharose; D013314:Stress, Mechanical
chemical_list: D005782:Gels; D012685:Sepharose