title: Benign and malignant breast lesions: differentiation with echo-planar MR imaging.
abstract: OBJECTIVE
  To quantify dynamic enhancement of breast lesions with echo-planar and conventional magnetic resonance (MR) imaging, to correlate these data with histologic findings and vessel density, and to evaluate
  
  
  METHODS
  Twenty female patients with 22 breast lesions underwent conventional and MR echo-planar imaging T1 values, change in gadopentetate dimeglumine concentration, and extraction-flow products were calculated with echo-planar imaging data and were correlated with histologic findings and microvessel density.
  
  
  RESULTS
  T1 values of cancers were not statistically significantly shorter. Cancers had more rapid uptake and higher extraction-flow products (P < .02). Sensitivity was 86% and specificity was 93% for diagnosis of malignancy. Microvessel density was higher for malignant lesions (P < .02) with an overall positive (not statistically significant) correlation between extraction-flow product and microvessel density.
  
  
  CONCLUSIONS
  Echo-planar imaging appears promising for quantification of breast lesion enhancement. Microvessel data indicate that tumor angiogenesis affects enhancement.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Hulka
authors.forename: B L
authors.initials: BL
authors.lastname: Smith
authors.forename: D C
authors.initials: DC
authors.lastname: Sgroi
authors.forename: L
authors.initials: L
authors.lastname: Tan
authors.forename: W B
authors.initials: WB
authors.lastname: Edmister
authors.forename: J P
authors.initials: JP
authors.lastname: Semple
authors.forename: T
authors.initials: T
authors.lastname: Campbell
authors.forename: D B
authors.initials: DB
authors.lastname: Kopans
authors.forename: T J
authors.initials: TJ
authors.lastname: Brady
authors.forename: R M
authors.initials: RM
authors.lastname: Weisskoff
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001941:Breast Diseases / Q000175:diagnosis*; D001943:Breast Neoplasms / Q000175:diagnosis; D002278:Carcinoma in Situ / Q000175:diagnosis; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged