title: Significance of the hepatic mitochondrial redox state in the development of posttraumatic jaundice.
abstract: The effect of the hepatic energy status on the development of posttraumatic jaundice (PTJ) was studied to clarify the mechanism of PTJ. Fifty-four patients with severe torso injury who were expected to develop PTJ on admission with an average Injury Severity Score of 27 were selected for this study. They were retrospectively divided into three groups according to their maximum bilirubin concentration by day 10: group H, 12 patients with marked elevation of serum bilirubin (> 8 g/dl); group L, 23 with mild bilirubinemia (2-8 g/dl); and group N, 19 with no bilirubinemia (< 2 g/dl). Group H patients, in whom trauma-related shock was severe and prolonged, developed severe hyperbilirubinemia, and their arterial ketone body ratio (AKBR), which reflects the hepatic mitochondrial redox state and is closely correlated to its energy production, was significantly lower throughout the first week. In contrast, the AKBR increased to an above normal level, indicating enhanced energy production in groups N and L. The serum direct/total bilirubin was also higher in group H. The abnormal hepatic energy metabolism is considered to have reduced the excretion of conjugated bilirubin from the hepatocytes into the bile canaliculi, which is a process that has to proceed against the bilirubin concentration gradient. The subsequent diffusion of the accumulated water-soluble conjugated bilirubin in hepatocytes into the blood is thus considered to be one of the causes of PTJ.
authors.affiliation: Trauma and Critical Care Center, Teikyo University School of Medicine, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Nakatani
authors.forename: Y
authors.initials: Y
authors.lastname: Endoh
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D000328:Adult; D001663:Bilirubin / Q000097:blood; D001693:Biological Transport, Active / Q000502:physiology; D002352:Carrier Proteins / Q000378:metabolism; D002780:Cholestasis, Intrahepatic / Q000503:physiopathology*; D004734:Energy Metabolism / Q000502:physiology*; D005260:Female; D006801:Humans; D006932:Hyperbilirubinemia / Q000503:physiopathology; D015601:Injury Severity Score; D007657:Ketone Bodies / Q000097:blood; D008111:Liver Function Tests; D008297:Male; D008930:Mitochondria, Liver / Q000502:physiology*; D009104:Multiple Trauma / Q000503:physiopathology*; D010084:Oxidation-Reduction; D012189:Retrospective Studies; D012307:Risk Factors; D012774:Shock, Traumatic / Q000503:physiopathology
chemical_list: D002352:Carrier Proteins; D007657:Ketone Bodies; C029783:bilirubin binding protein, human; D001663:Bilirubin