title: Functional properties of intracellular calcium-release channels.
abstract: Two major classes of intracellular calcium-release channels have been identified, the ryanodine receptor and the inositol 1,4,5-trisphosphate receptor. These channels are the largest ion channels identified to date. Recent studies have established that approximately 90% of each of these proteins protrudes into the cytoplasm, presumably exposing many regulatory sites on the channel and allowing functional interactions with other cytoplasmic proteins. Current work is aimed at understanding the molecular mechanisms and cellular roles of these regulatory processes.
authors.affiliation: Department of Physiology, University of Connecticut, Farmington 06030-3505, USA.
authors.forename: B E
authors.initials: BE
authors.lastname: Ehrlich
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000145:classification* / Q000502:physiology*; D008954:Models, Biological; D009124:Muscle Proteins / Q000502:physiology; D019837:Ryanodine Receptor Calcium Release Channel
chemical_list: D015220:Calcium Channels; D009124:Muscle Proteins; D019837:Ryanodine Receptor Calcium Release Channel; D002118:Calcium