title: Intraoperative thrombolytic treatment of microarterial occlusion by selective rt-PA infusion.
abstract: The development of microvascular thrombosis during replantation surgery or free-flap transfer is generally best treated by identification of the problem, vascular revision, and reanastomosis. It is not unique, however, that surgical measures alone are insufficient or undesirable. Pharmacologic adjuncts are widely used for the prevention and sometimes treatment of microvascular thrombosis in surgical practice, but the benefit of thrombolytic agents, effective in dissolving an already established thrombus, is usually considered counterlevered by the fear of uncontrollable bleeding. However, selective infusion of the drug reduces the risk for systemic complications considerably and may therefore be considered in peripheral microvascular reconstruction. The technique was used successfully in a case of digital revascularization, where an arterial thrombosis was dissolved with the use of recombinant tissue plasminogen activator (rt-PA).
authors.affiliation: Department of Hand Surgery, University of Umeå, Sweden.
authors.forename: J M
authors.initials: JM
authors.lastname: Stassen
authors.forename: G
authors.initials: G
authors.lastname: Lü
authors.forename: O
authors.initials: O
authors.lastname: Andréen
authors.forename: E
authors.initials: E
authors.lastname: Nyström
authors.forename: A
authors.initials: A
authors.lastname: Nyström
mesh_terms: D000328:Adult; D005343:Fibrinolytic Agents / Q000008:administration & dosage*; D006225:Hand / Q000601:surgery; D006801:Humans; D007261:Infusions, Intra-Arterial; D007430:Intraoperative Care; D007431:Intraoperative Complications / Q000188:drug therapy*; D008297:Male; D011994:Recombinant Proteins / Q000008:administration & dosage; D012092:Replantation; D013524:Surgical Flaps; D015912:Thrombolytic Therapy / Q000379:methods*; D013927:Thrombosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D005343:Fibrinolytic Agents; D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator