title: Neutrophilic dermatoses during granulocytopenia.
abstract: METHODS
  Noninfectious cutaneous neutrophilic lesions can occur during granulocytopenia, but their mechanism remains unknown. We undertook a retrospective study of the neutrophilic dermatoses that developed during granulocytopenia induced by chemotherapy for acute myelogenous leukemia.
  
  
  RESULTS
  Seven men and one woman were included (2.6% of treated cases of acute myelogenous leukemia); half had acute myelogenous leukemia subtypes 4 and 5. The male-to-female ratio was 7:1. Neutrophilic eccrine hidradenitis was diagnosed in five cases, Sweet's syndrome in two cases, and difficult-to-classify neutrophilic dermatoses in one case. Cutaneous lesions appeared 12.5 days after the start of chemotherapy, and the mean leukocyte count was 0.426 x 10(9)/L. Three patients needed corticosteroids systemically.
  
  
  CONCLUSIONS
  Neutrophilic dermatoses during chemotherapy-induced granulocytopenia seem to occur more frequently in men with acute myelogenous leukemia subtypes 4 and 5.
authors.affiliation: Department of Dermatology, Hôpital Saint-Louis, Paris, France.
authors.forename: S
authors.initials: S
authors.lastname: Aractingi
authors.forename: V
authors.initials: V
authors.lastname: Mallet
authors.forename: L
authors.initials: L
authors.lastname: Pinquier
authors.forename: O
authors.initials: O
authors.lastname: Chosidow
authors.forename: M D
authors.initials: MD
authors.lastname: Vignon-Pennamen
authors.forename: L
authors.initials: L
authors.lastname: Degos
authors.forename: L
authors.initials: L
authors.lastname: Dubertret
authors.forename: H
authors.initials: H
authors.lastname: Dombret
mesh_terms: D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000150:complications*; D005260:Female; D016575:Hidradenitis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology; D012189:Retrospective Studies; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology; D016463:Sweet Syndrome / Q000209:etiology* / Q000473:pathology