Pharmacokinetics of cefotaxime in dialysis patients.
A literature review was carried out to assess the effect of hemodialysis, hemofiltration, and continuous ambulatory peritoneal dialysis on the pharmacokinetics of cefotaxime, particularly in patients with severe renal impairment. It was concluded that the dosage of cefotaxime, adjusted for renal function, would require no further adjustment during peritoneal dialysis or hemofiltration.
Andrassy
K
K
Department of Internal Medicine, University Hospital, Heidelberg, Germany.
D000328:Adult; D001424:Bacterial Infections / Q000150:complications / Q000188:drug therapy; D002439:Cefotaxime / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002511:Cephalosporins / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002675:Child, Preschool; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications; D006435:Renal Dialysis
D002511:Cephalosporins; D002439:Cefotaxime