title: Threshold of estimated toxicity for regulation of indirect food additives.
abstract: In response to the objectives of this ATSDR workshop, 2 new procedures are described for assessing the safe use of indirect food additives. First, this workshop provided a timely forum in which to describe a newly proposed Threshold of Regulation (T/R) Policy under which the Food and Drug Administration (FDA) would exempt certain indirect food additives from the formal premarket petition process. Second, this workshop offered an opportunity to discuss 2 circumstances in which Quantitative Structure Activity Relationship (QSAR) methodologies might be utilized in the future to provide decision-support information for substances used in food-contact articles.
authors.affiliation: Food and Drug Administration, Washington, DC 20204, USA.
authors.forename: E J
authors.initials: EJ
authors.lastname: Matthews
authors.forename: E J
authors.initials: EJ
authors.lastname: Machuga
mesh_terms: D005503:Food Additives / Q000633:toxicity; D006801:Humans; D007878:Legislation as Topic; D013329:Structure-Activity Relationship; D014481:United States; D014486:United States Food and Drug Administration
chemical_list: D005503:Food Additives