Chronic hypertrophic cranial pachymeningitis associated with HTLV-I infection.
Two patients presenting with recurrent multiple cranial neuropathy showed diffuse thickening and gadolinium enhancement of the dura mater on brain MRI. Both had anti-HTLV-I antibodies in serum. A quantitative polymerase chain reaction study of the peripheral blood disclosed that the HTLV-I proviral DNA loads increased considerably in one case and moderately in the other. Both showed a spontaneous proliferation of peripheral blood lymphocytes as well as an increase in helper/inducer T cells. Neither had any other underlying infections or autoimmune diseases. Thus it is possible that hypertrophic pachymeningitis developed as a result of multiorgan involvement of HTLV-I infection in these patients.
Kawano
Y
Y
Department of Neurology, Faculty of Medicine, Kyushu University 60, Fukuoka, Japan.
Kira
J
J
D000328:Adult; D001921:Brain / Q000473:pathology; D002908:Chronic Disease; D004279:DNA, Viral / Q000032:analysis; D004388:Dura Mater / Q000473:pathology*; D015490:HTLV-I Infections / Q000150:complications* / Q000276:immunology / Q000821:virology; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008581:Meningitis / Q000150:complications* / Q000473:pathology; D008875:Middle Aged; D016133:Polymerase Chain Reaction
D004279:DNA, Viral