title: Secretogranin II: molecular properties, regulation of biosynthesis and processing to the neuropeptide secretoneurin.
abstract: Secretogranin II is an acidic secretory protein in large dense core vesicles of endocrine, neuroendocrine and neuronal tissues. It comprises, together with chromogranins A and B, the class of proteins collectively called chromogranins. In this review the physico-chemical properties, genomic organization, tissue distribution, synthesis regulation, ontogeny and physiological function of this protein are discussed. Secretogranin II gained interest recently for mainly three reasons: (1) secretogranin II is an excellent marker for the regulated secretory pathway due to its simple and specific metabolic labeling by inorganic sulfate; (2) secretogranin II occurs in a variety of neoplasms arising from endocrine and neuroendocrine cells and was shown to be a useful histological tumor marker for these cells; (3) secretogranin II is the precursor of the recently discovered neuropeptide secretoneurin which induces dopamine release in the striatum of the rat brain.
authors.affiliation: Department of Pharmacology, University of Innsbruck, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Fischer-Colbrie
authors.forename: A
authors.initials: A
authors.lastname: Laslop
authors.forename: R
authors.initials: R
authors.lastname: Kirchmair
mesh_terms: D000818:Animals; D002864:Chromogranins; D009479:Neuropeptides / Q000096:biosynthesis* / Q000502:physiology; D014176:Protein Biosynthesis; D011506:Proteins / Q000502:physiology*; D053381:Secretogranin II; D014018:Tissue Distribution
chemical_list: D002864:Chromogranins; D009479:Neuropeptides; D011506:Proteins; D053381:Secretogranin II; C081159:secretoneurin