title: Changes in the incidence and mortality of testicular cancer in Scotland with particular reference to the outcome of older patients treated for non-seminomatous germ cell tumours.
abstract: This paper describes the temporal pattern of germ cell testicular cancer in Scotland between 1960 and 1990. The effect of age on the prognosis of patients with non-seminomatous germ cell tumours (NSGCT) has been assessed by studying all patients presenting in the West of Scotland between 1975 and 1989. Between 1960 and 1990, the number of testicular germ cell tumours registered has increased more than 2-fold; mortality rates have declined equally dramatically. Univariate and multivariate analysis of the data obtained on 440 patients with NSGCT showed age was not a prognostic factor influencing survival. 52 were patients over 40 years at presentation; their 5 years survival was 71% compared with 79% in the younger patients (n = 388). This small survival difference is probably explained by the higher proportion of older patients treated before 1980. Treatment for this older group should be approached with the same curative intent as for younger patients and the same expectation of success.
authors.affiliation: Beatson Oncology Centre, Western Infirmary, Glasgow.
authors.forename: M Q
authors.initials: MQ
authors.lastname: Hatton
authors.forename: J
authors.initials: J
authors.lastname: Paul
authors.forename: M
authors.initials: M
authors.lastname: Harding
authors.forename: G
authors.initials: G
authors.lastname: MacFarlane
authors.forename: A G
authors.initials: AG
authors.lastname: Robertson
authors.forename: S B
authors.initials: SB
authors.lastname: Kaye
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D018237:Germinoma / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D012606:Scotland / Q000453:epidemiology; D016019:Survival Analysis; D013724:Teratoma / Q000188:drug therapy / Q000453:epidemiology / Q000401:mortality / Q000473:pathology; D013736:Testicular Neoplasms / Q000188:drug therapy / Q000453:epidemiology* / Q000401:mortality / Q000473:pathology; D013997:Time Factors