Ventilatory post-stimulus potentiation in patients with brain damage.
In normal humans when a brief hypoxic ventilatory stimulus is terminated abruptly by breathing 100% O2, ventilation during hyperoxia gradually declines to baseline prehypoxic levels without an undershoot. This has been interpreted as evidence of decay of short-term potentiation (STP), a mechanism located in the brainstem and not dependent upon higher center inputs. STP decay may be important in preventing periodic breathing by damping ventilatory responses to cyclic stimuli. Patients with brain damage commonly have periodic breathing that may be caused partly by impairment of STP activation. To test this 12 tracheostomized patients with severe brain damage (Glasgow score 9.9 +/- 0.6) were studied. Breathing stability was estimated by at least 6 h of capnography and from these records apnea index (AI, episodes/hour) and cyclic changes of end-tidal CO2 (c-PETCO2, cycles/hour) were derived. STP activation was examined by brief exposure to hypoxia (45 s, end-tidal O2 = 50 mm Hg) followed by hyperoxia. Forty-four hypoxic-hyperoxic runs were analyzed and compared with 19 normoxic-hyperoxic trials. At the end of the hypoxia ventilation (VI) increased 39.5 +/- 5.8% and PETCO2 decreased 2.7 +/- 0.6 mm Hg to 91.5 +/- 2.2% of baseline value. When hypoxia was terminated abruptly by hyperoxia VI dropped immediately to 63.2 +/- 7.2% of baseline, remaining for 35 s significantly lower than the corresponding values acquired during hyperoxia after normoxia. After hypoxia, apneas occurred in 19 of 44 hyperoxic runs. There was a negative relationship between nadir hyperoxic ventilation after hypoxia and both AI and c-PETCO2.(ABSTRACT TRUNCATED AT 250 WORDS)
Georgopoulos
D
D
General Hospital G. Papanicolaou, Department of Pulmonary and Critical Care Medicine, University of Thessaloniki, Exoxi, Greece.
Mitrouska
I
I
Koletsos
K
K
Markopoulou
K
K
Riggos
D
D
Patakas
D
D
Anthonisen
N R
NR
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001925:Brain Damage, Chronic / Q000503:physiopathology*; D001944:Breath Tests; D002245:Carbon Dioxide / Q000032:analysis / Q000502:physiology; D005260:Female; D006801:Humans; D018496:Hyperoxia / Q000503:physiopathology; D000860:Hypoxia / Q000503:physiopathology; D008297:Male; D012119:Respiration / Q000502:physiology*; D013997:Time Factors
D002245:Carbon Dioxide