title: Hydrolytic degradation of benzylated poly(beta-malic acid): influence of sample size, sample shape, and polymer composition.
abstract: In order to investigate the effects of sample size, sample shape, and polymer composition on the hydrolytic degradation of water-insoluble benzylated poly(beta-malic acid) derivatives, three polymers were synthesized, namely PMLABe100, PMLABe90H10 and PMLABe80H20, containing 100, 90, and 80% of benzyl units respectively. For each polymer, 4-mm-thick compression molded pellets, 0.3-mm-thick casted films and 250-500 microns ground particles were made and allowed to age in 0.13 M, pH 7.4 sodium phosphate buffer at 37 degrees C. Degradation was monitored by measuring weight changes, variations of polymer composition, formation of benzyl alcohol, and molecular weight decreases. It was shown that degradation of particles and films depended initially on polymer composition due primarily to fast degradation of acid-rich segments present or formed by benzyl ester cleavages which led more or less rapidly to similar compositions for the three polymers. The higher the content in acid groups, the faster the degradation rate and the characteristic changes. It was also found that pellets made of PMLABe90H10 or PMLABe80H20 degraded heterogeneously and much faster than corresponding films and particles.
authors.affiliation: CRBA-URA CNRS 1465, University Montpellier 1, Faculty of Pharmacy, Montpellier, France.
authors.forename: J
authors.initials: J
authors.lastname: Mauduit
authors.forename: M
authors.initials: M
authors.lastname: Boustta
authors.forename: M
authors.initials: M
authors.lastname: Vert
mesh_terms: D001555:Benzene Derivatives / Q000737:chemistry*; D019905:Benzyl Alcohol; D001592:Benzyl Alcohols / Q000378:metabolism; D001672:Biocompatible Materials; D002152:Calorimetry, Differential Scanning; D002850:Chromatography, Gel; D006868:Hydrolysis; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008293:Malates / Q000737:chemistry*; D008970:Molecular Weight; D010316:Particle Size; D011108:Polymers / Q000138:chemical synthesis* / Q000737:chemistry; D011199:Potentiometry; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001555:Benzene Derivatives; D001592:Benzyl Alcohols; D001672:Biocompatible Materials; D008293:Malates; D011108:Polymers; C030298:malic acid; D019905:Benzyl Alcohol