title: Influence of progesterone and its antagonist mifepristone (RU 486) on collagen content in uterine cervix in pregnant rats.
abstract: Total collagen and its soluble fraction as well as water content were determined in late pregnancy in the uterine cervix in a population of 36 rats treated with progesterone (n = 10), mifepristone (n = 13) and controls (n = 13). In both treated groups there were no signs of delivery on the 21st day of gestation. Water content was significantly lower in the mifepristone-treated group. A statistically higher soluble collagen fraction was observed in this group. The results obtained in the progesterone-treated group were not significantly different when compared to the controls. Significant differences were observed between progesterone- and mifepristone-treated groups in total and soluble fractions of collagen.
authors.affiliation: Institute of Obstetrics and Gynecology, Medical University of Lódź, Poland.
authors.forename: A
authors.initials: A
authors.lastname: Bieńkiewicz
mesh_terms: D000818:Animals; D001834:Body Water / Q000378:metabolism; D002584:Cervix Uteri / Q000187:drug effects* / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D005260:Female; D015735:Mifepristone / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D015735:Mifepristone; D011374:Progesterone; D003094:Collagen