title: Phase II trial of CHIP for the treatment of advanced, hormonally refractory carcinoma of the prostate. A Southwest Oncology Group Study.
abstract: CHIP, a second generation analogue of cisplatin, was subjected to a Phase II trial for the treatment of advanced, hormonally refractory carcinoma of the prostate. Forty-six patients were treated with CHIP 300 mg/m2 intravenously every 4 weeks. Evaluations for tumor response were done after three cycles of therapy. Among 40 evaluable patients there were no complete responses, but there were 6 partial responses for an overall response rate of 15% (95% confidence interval of 5.7 to 29.8%). The median time to response was 2.4 months and the median progression-free survival was 4.1 months. Median survival was 8.4 months. The most common toxicities were hematologic and gastrointestinal. While CHIP can be administered on an outpatient basis, its response rate for prostatic carcinoma appears to be similar to that of cisplatin.
authors.affiliation: University of Cincinnati, Ohio, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Marshall
authors.forename: M K
authors.initials: MK
authors.lastname: Wolf
authors.forename: E D
authors.initials: ED
authors.lastname: Crawford
authors.forename: G R
authors.initials: GR
authors.lastname: Weiss
authors.forename: F
authors.initials: F
authors.lastname: Ahmann
authors.forename: F J
authors.initials: FJ
authors.lastname: Meyers
authors.forename: B
authors.initials: B
authors.lastname: Blumenstein
authors.forename: M
authors.initials: M
authors.lastname: Eisenberger
authors.forename: A B
authors.initials: AB
authors.lastname: Einstein
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary*; D000368:Aged; D000369:Aged, 80 and over; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009376:Neoplasms, Hormone-Dependent / Q000188:drug therapy*; D009944:Organoplatinum Compounds / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D016019:Survival Analysis
chemical_list: D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; C023359:iproplatin