title: Pherophorins: a family of extracellular matrix glycoproteins from Volvox structurally related to the sex-inducing pheromone.
abstract: Pherophorins are extracellular matrix (ECM) glycoproteins from Volvox that share homology with the sex-inducing pheromone. A novel pherophorin (pherophorin III) was characterized both with respect to expression pattern and proteolytic processing in vivo. Furthermore, it was shown that the pherophorins represent a protein family of ECM glycoproteins exhibiting a modular composition: their N-terminally located domain is a homolog of a domain found in the ECM glycoprotein SSG 185. Together with SSG 185, pherophorin I is a main component of the cellular zone within the ECM. The Volvox genome contains a tandem arrangement of genes encoding pherophorin II-related polypeptides. Inhibition of proteolytic processing of pherophorin II and III in vivo appears to result in the suppression of sexual induction.
authors.affiliation: Lehrstuhl Biochemie I, Universität Regensburg, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Godl
authors.forename: A
authors.initials: A
authors.lastname: Hallmann
authors.forename: A
authors.initials: A
authors.lastname: Rappel
authors.forename: M
authors.initials: M
authors.lastname: Sumper
mesh_terms: D020418:Algal Proteins; D000595:Amino Acid Sequence; D000460:Chlorophyta / Q000737:chemistry* / Q000235:genetics / Q000502:physiology; D016326:Extracellular Matrix Proteins / Q000737:chemistry* / Q000235:genetics; D006023:Glycoproteins / Q000737:chemistry* / Q000235:genetics; D006868:Hydrolysis; D008969:Molecular Sequence Data; D005810:Multigene Family; D017386:Sequence Homology, Amino Acid; D012724:Sex Attractants; D012967:Sodium Dodecyl Sulfate; D012995:Solubility
chemical_list: D020418:Algal Proteins; D016326:Extracellular Matrix Proteins; D006023:Glycoproteins; D012724:Sex Attractants; D012967:Sodium Dodecyl Sulfate