Genetic mapping and expression analysis of the murine DNA ligase I gene.
We mapped the murine DNA ligase I gene (Lig1) in the mouse genome by using a mapping panel from an interspecific cross. Lig1 mapped to a centromeric part of chromosome 7, a region homologous to human chromosome 19q, where the human homologue LIG1 was localized. In addition, Lig1 expression was analyzed during the course of mouse liver-cell regeneration induced by partial hepatectomy, necrogenic doses of carbon tetrachloride, or the mitogen 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene. The results demonstrate that Lig1 is expressed in the liver during active cell proliferation.
Gariboldi
M
M
Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy.
Montecucco
A
A
Columbano
A
A
Ledda-Columbano
G M
GM
Savini
E
E
Manenti
G
G
Pierotti
M A
MA
Dragani
T A
TA
D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D002455:Cell Division; D002874:Chromosome Mapping; D011088:DNA Ligases / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D008040:Genetic Linkage; D006498:Hepatectomy; D008115:Liver Regeneration; D008297:Male; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains; D012150:Polymorphism, Restriction Fragment Length; D011725:Pyridines / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics
D011725:Pyridines; D012333:RNA, Messenger; C028474:1,4-bis(2-(3,5-dichloropyridyloxy))benzene; D011088:DNA Ligases