Developmental abnormalities and cortical sulcal enlargement in psychosis.
Neurodevelopmental abnormalities and cortical sulcal enlargement both occur in schizophrenia. To test the hypothesis that these abnormalities were related, CT scans from 164 psychotic patients (80 with schizophrenia) were reviewed. Neurodevelopmental abnormalities were observed in 11%. Abnormalities were equally prevalent in schizophrenia and other psychotic disorders. Cortical sulcal enlargement was observed in 39% of patients with schizophrenia, and was not associated with developmental abnormalities. Different mechanisms may contribute to distinct structural abnormalities.
Honer
W G
WG
Department of Psychiatry, University of British Columbia, Jack Bell Research Centre, Vancouver, Canada.
Squires-Wheeler
E
E
Smith
G N
GN
Sharif
Z
Z
Chan
S
S
Gewirtz
G
G
D000293:Adolescent; D000328:Adult; D000368:Aged; D001714:Bipolar Disorder / Q000000981:diagnostic imaging / Q000523:psychology; D001925:Brain Damage, Chronic / Q000000981:diagnostic imaging* / Q000523:psychology; D002540:Cerebral Cortex / Q000002:abnormalities* / Q000000981:diagnostic imaging; D003866:Depressive Disorder / Q000000981:diagnostic imaging / Q000523:psychology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D019965:Neurocognitive Disorders / Q000000981:diagnostic imaging* / Q000523:psychology; D011618:Psychotic Disorders / Q000000981:diagnostic imaging / Q000523:psychology; D012307:Risk Factors; D012559:Schizophrenia / Q000000981:diagnostic imaging*; D012565:Schizophrenic Psychology; D014057:Tomography, X-Ray Computed