title: The oncogene qin codes for a transcriptional repressor.
abstract: The retroviral oncogene qin codes for a protein that belongs to the winged helix family of transcriptional regulators. The Qin protein is localized in the nucleus and binds to the same DNA consensus sequence as rat brain factor 1 (BF-1). Cellular Qin shows greater affinity to DNA than does viral Qin. Alone or fused to the DNA-binding domain of the yeast GAL4 protein, both Qin proteins act as transcriptional repressors. The major transcriptional repression domain maps to the region of amino acids 252-395 of viral Qin.
authors.affiliation: Department of Molecular and Experimental Medicine, Scripps Research Institute, La Jolla, California 92037, USA.
authors.forename: J
authors.initials: J
authors.lastname: Li
authors.forename: H W
authors.initials: HW
authors.lastname: Chang
authors.forename: E
authors.initials: E
authors.lastname: Lai
authors.forename: E J
authors.initials: EJ
authors.lastname: Parker
authors.forename: P K
authors.initials: PK
authors.lastname: Vogt
mesh_terms: D000595:Amino Acid Sequence; D030161:Avian Proteins; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D005656:Fungal Proteins / Q000378:metabolism; D008969:Molecular Sequence Data; D009687:Nuclear Proteins / Q000502:physiology*; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins / Q000502:physiology*; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D014158:Transcription, Genetic; D014764:Viral Proteins
chemical_list: D030161:Avian Proteins; D004268:DNA-Binding Proteins; D051858:Forkhead Transcription Factors; D005656:Fungal Proteins; C052130:GAL4 protein, S cerevisiae; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D029701:Saccharomyces cerevisiae Proteins; D014157:Transcription Factors; D014764:Viral Proteins; C490425:v-qin protein, Avian sarcoma virus 31; D004247:DNA