title: Inducible nitric oxide synthase in the central nervous system.
abstract: There is an accumulation of evidence indicating that induction of the calcium-independent isoform of nitric oxide synthase (iNOS) in glial cells can contribute to nitric oxide-mediated neural-cell damage. Elucidation of iNOS inducing signals and mechanisms regulating its augmentation and suppression may have implications for our understanding of basic processes underlying some forms of central nervous system disease.
authors.affiliation: Department of Ophthalmology, Cornell University Medical College, New York, NY 10021, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Sparrow
mesh_terms: D015526:AIDS Dementia Complex / Q000201:enzymology / Q000473:pathology; D000818:Animals; D001253:Astrocytes / Q000201:enzymology; D001927:Brain Diseases / Q000201:enzymology / Q000473:pathology; D016923:Cell Death; D002490:Central Nervous System / Q000201:enzymology*; D004660:Encephalitis / Q000201:enzymology / Q000473:pathology; D004790:Enzyme Induction; D006801:Humans; D007527:Isoenzymes / Q000096:biosynthesis / Q000502:physiology; D051379:Mice; D009419:Nerve Tissue Proteins / Q000096:biosynthesis / Q000502:physiology*; D009457:Neuroglia / Q000201:enzymology; D009474:Neurons / Q000473:pathology; D009569:Nitric Oxide / Q000378:metabolism; D019001:Nitric Oxide Synthase / Q000096:biosynthesis / Q000502:physiology*; D051381:Rats
chemical_list: D007527:Isoenzymes; D009419:Nerve Tissue Proteins; D009569:Nitric Oxide; D019001:Nitric Oxide Synthase