title: Poly(ADP-ribose) polymerase: structure-function relationship.
abstract: Dissection of the human poly(ADP-ribose) polymerase (PARP) molecule in terms of its structure-function relationship has proved to be an essential step towards understanding the biological role of poly(ADP-ribosylation) as a cellular response to DNA damage in eukaryotes. Current approaches aimed at elucidating the implication of this multifunctional enzyme in the maintenance of the genomic integrity will be presented.
authors.affiliation: Ecole Supérieure de Biotechnologie de Strasbourg, UPR 9003 du CNRS, Illkirch, France.
authors.forename: M
authors.initials: M
authors.lastname: Masson
authors.forename: V
authors.initials: V
authors.lastname: Rolli
authors.forename: F
authors.initials: F
authors.lastname: Dantzer
authors.forename: C
authors.initials: C
authors.lastname: Trucco
authors.forename: V
authors.initials: V
authors.lastname: Schreiber
authors.forename: S
authors.initials: S
authors.lastname: Fribourg
authors.forename: M
authors.initials: M
authors.lastname: Molinete
authors.forename: A
authors.initials: A
authors.lastname: Ruf
authors.forename: E A
authors.initials: EA
authors.lastname: Miranda
authors.forename: C
authors.initials: C
authors.lastname: Niedergang
mesh_terms: D000818:Animals; D002384:Catalysis; D002645:Chickens; D003460:Crystallization; D018360:Crystallography, X-Ray; D004249:DNA Damage; D004260:DNA Repair; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000502:physiology; D015894:Genome, Human; D006367:HeLa Cells; D006801:Humans; D011065:Poly(ADP-ribose) Polymerases / Q000737:chemistry* / Q000502:physiology*; D017434:Protein Structure, Tertiary; D011994:Recombinant Proteins / Q000737:chemistry; D013329:Structure-Activity Relationship; D014162:Transfection
chemical_list: D004268:DNA-Binding Proteins; D011994:Recombinant Proteins; D011065:Poly(ADP-ribose) Polymerases