Acquisition, retention, and extinction of operant discriminations in rats with nucleus basalis magnocellularis lesions.
Effects of bilateral ibotenic acid lesions of nucleus basalis magnocellularis (NBM) and scopolamine treatment on different aspects of learning and memory in an operant discrimination task were assessed. In Experiment 1, NBM lesions impaired acquisition performance. In Experiment 2, scopolamine lowered response rates but did not affect discrimination accuracy in lesioned or control rats. In Experiment 3, although pretrained rats showed transient increases in commission errors, percentage correct responding remained above chance levels after lesion. During extinction in Experiment 4, operant responding diminished more quickly in pretrained NBM-lesioned rats than in controls, but subsequent reacquisition performance was equivalent in both groups. Results suggest the NBM is importantly involved in discrimination learning, but cholinergic activity may be less critical for memory retention than for acquisition.
Butt
A E
AE
Department of Psychology, University of New Mexico, Albuquerque 87131-1161, USA.
Hodge
G K
GK
D000818:Animals; D001070:Appetitive Behavior / Q000502:physiology*; D001288:Attention / Q000502:physiology; D001931:Brain Mapping; D002540:Cerebral Cortex / Q000502:physiology; D002799:Cholinergic Fibers / Q000502:physiology*; D004193:Discrimination Learning / Q000502:physiology*; D004292:Dominance, Cerebral / Q000502:physiology; D005108:Extinction, Psychological / Q000502:physiology*; D008297:Male; D011939:Mental Recall / Q000502:physiology; D009042:Motivation; D009434:Neural Pathways / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012153:Retention, Psychology / Q000502:physiology*; D013377:Substantia Innominata / Q000502:physiology*