Spontaneous remission of post-stroke depression and temporal changes in cortical S2-serotonin receptors.
A patient with post-stroke depression following infarction of the left basal ganglia is described. The patient's depression remitted during a 6-week double-blind treatment trial while receiving placebo medication. Cortical S2-receptor binding that was measured using 11C-N methyl spiperone and positron emission tomography (PET), increased in the left temporal cortex by more than 25% during the treatment trial. The change in serotonin receptor binding and its relationship to the improvement in mood observed in this patient are consistent with previously published data demonstrating a correlation between serotonin receptor binding in the left temporal cortex and severity of symptoms of depression.
Mayberg
H S
HS
Department of Radiology, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Parikh
R M
RM
Morris
P L
PL
Robinson
R G
RG
D002540:Cerebral Cortex / Q000378:metabolism*; D002561:Cerebrovascular Disorders / Q000150:complications / Q000523:psychology*; D003863:Depression / Q000209:etiology / Q000523:psychology*; D005260:Female; D006801:Humans; D008875:Middle Aged; D011985:Receptors, Serotonin / Q000378:metabolism*; D012075:Remission, Spontaneous
D011985:Receptors, Serotonin