title: [Efficacy and tolerance of praziquantel (Biltricide) in the treatment of distomatosis caused by Fasciola hepatica].
abstract: OBJECTIVE
  Due to the side-effects of dehydroemetine, we have chosen praziquantel, a broad-spectrum antihelmintic, as a treatment for distomatosis secondary to Fasciola hepatica in humans. The aim of this retrospective study was to evaluate the efficacy and tolerance to praziquantel in patients with this disease.
  
  
  METHODS
  Twenty-five patients (12 men) with a definite diagnosis of distomatosis and no previous treatment were followed-up between 8 months and 3 years (> 18 months in 76% of cases). The follow-up was based on clinical, biochemical and serological criteria. All patients received praziquantel (75 mg/kg/day orally) for 5 days. Treatment was started after endoscopic or surgical removal of parasites locolized in the biliary tract, in two patients. A similar therapeutic course was administered twice in four patients with persistent clinical symptoms, hypereosinophilia or arch 2 on immunoelectrophoresis.
  
  
  RESULTS
  Cumulative rates of patients with normalized eosinophilia and seronegativation at 6, 9 and 12 months were 55, 65, 75% and 55, 70, 100%, respectively. Complete recovery occurred in 18 patients (72%) whereas hypereosinophilia persisted for more than one year in 5 patients. No side-effects, except transient nausea in a few cases, were observed.
  
  
  CONCLUSIONS
  Since praziquantel seems to be both effective and well tolerated in a large proportion of patients, this drug can be recommended as a first choice for distomatosis due to Fasciola hepatica in human.
authors.affiliation: Service de Gastroentérologie et Nutrition, CHU-Rangueil, Toulouse.
authors.forename: J A
authors.initials: JA
authors.lastname: Moreau
authors.forename: J
authors.initials: J
authors.lastname: Fernandez
authors.forename: P
authors.initials: P
authors.lastname: Recco
authors.forename: J P
authors.initials: JP
authors.lastname: Seguela
authors.forename: J
authors.initials: J
authors.lastname: Frexinos
mesh_terms: D000328:Adult; D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis; D000980:Antiplatyhelmintic Agents / Q000009:adverse effects / Q000627:therapeutic use*; D004802:Eosinophilia / Q000209:etiology; D005210:Fasciola hepatica / Q000302:isolation & purification*; D005211:Fascioliasis / Q000150:complications / Q000188:drug therapy* / Q000276:immunology / Q000469:parasitology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011223:Praziquantel / Q000009:adverse effects / Q000627:therapeutic use*; D012189:Retrospective Studies
chemical_list: D000909:Antibodies, Helminth; D000980:Antiplatyhelmintic Agents; D011223:Praziquantel
vernacular_title: Efficacité et tolérance du praziquantel (Biltricide) dans le traitement de la distomatose à Fasciola hepatica.