Block of spatial learning by mGluR agonist tADA in rats.
As demonstrated recently, mGluRs are involved in some forms of learning. We thus investigated the effect of tADA (trans-azetidine-2,4-dicarboxylic acid) applied intracerebroventricularly prior to learning a spatial alternation paradigm. Compared to controls, tADA treated animals were amnesic when tested for retention 24 hr after training. Effects of state-dependency were excluded. These data and our earlier work indicate that both mGluR agonists and antagonists can have memory-disrupting effects.
Riedel
G
G
Department of Neurophysiology, Federal Institute for Neurobiology, Magdeburg, Germany.
Wetzel
W
W
Kozikowski
A P
AP
Reymann
K G
KG
D000818:Animals; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory; D051381:Rats; D017208:Rats, Wistar; D017470:Receptors, Glutamate / Q000187:drug effects*; D013037:Spatial Behavior / Q000187:drug effects*
D003998:Dicarboxylic Acids; D018690:Excitatory Amino Acid Agonists; D017470:Receptors, Glutamate