[Assessment of iron absorption in children with chronic renal insufficiency].
The changes were compared of the iron curve in children with chronic renal failure and with terminal renal failure after oral loading dose of ferrous sulphate. Flat curve of absorption was found in both groups of patients with increased stores of systemic iron and high values of transferrin saturation index (TSI). Steep iron curve and very good absorption were found in all children with decreased serum level of ferritin and decreased TSI. The curves of iron absorption at serum ferritin level 250-500 ng/ml pointed to impaired absorption and depended on the initial TSI value and initial iron level in the serum. No significant differences were found in the shape of iron curve depending on dialysing methods. Studying of the iron curve and values of TSI in certain patients makes easier the decision of administration of treatment with oral iron preparations even with increased values of TSI and ferritin in the serum.
Roszkowska-Blaim
M
M
Katedry i Kliniki Pediatrii i Nefrologii Ak. Med. w Warszawie.
Korniszewska
J
J
Makarewicz
W
W
D000042:Absorption; D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D003692:Delayed-Action Preparations / Q000008:administration & dosage / Q000493:pharmacokinetics; D005293:Ferritins / Q000097:blood; D005296:Ferrous Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics; D006801:Humans; D007223:Infant; D007501:Iron / Q000493:pharmacokinetics*; D007676:Kidney Failure, Chronic / Q000378:metabolism*
D003692:Delayed-Action Preparations; D005296:Ferrous Compounds; C020748:ferrous sulfate; D005293:Ferritins; D007501:Iron
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