title: Relationships between proteasomes and RNA.
abstract: The 20S proteasome (prosome) is a highly organized multi-protein complex with approximate molecular weight of about 700 kDa. Whilst the role of the proteasome in the processing and turnover of cellular proteins is becoming clearer, its relationship with RNA remains obscure. Over the last decade the possibility of association of proteasomes with specific RNAs or mRNPs have been particularly controversial. Proteasomes were reported to inhibit translation of viral mRNAs and to be tightly associated with RNase activity. It is possible that proteasomes are also involved in cellular RNA breakdown and RNA processing like prokaryotic RNase E.
authors.affiliation: Université Blaise Pascal, Clermont-Ferrand II, Aubière, France.
authors.forename: H P
authors.initials: HP
authors.lastname: Schmid
authors.forename: M N
authors.initials: MN
authors.lastname: Pouch
authors.forename: F
authors.initials: F
authors.lastname: Petit
authors.forename: M H
authors.initials: MH
authors.lastname: Dadet
authors.forename: S
authors.initials: S
authors.lastname: Badaoui
authors.forename: G
authors.initials: G
authors.lastname: Boissonnet
authors.forename: J
authors.initials: J
authors.lastname: Buri
authors.forename: V
authors.initials: V
authors.lastname: Norris
authors.forename: Y
authors.initials: Y
authors.lastname: Briand
mesh_terms: D000818:Animals; D003546:Cysteine Endopeptidases / Q000378:metabolism*; D006801:Humans; D009097:Multienzyme Complexes / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D012313:RNA / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D012367:RNA, Viral / Q000378:metabolism; D012260:Ribonucleases / Q000378:metabolism
chemical_list: D009097:Multienzyme Complexes; D012333:RNA, Messenger; D012367:RNA, Viral; D012313:RNA; D012260:Ribonucleases; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex