title: Massive osteolysis of the cervical spine. A case report.
abstract: METHODS
  This study described the course of a case of massive osteolysis (Gorham's disease) of the cervical spine and discussed the literature data.
  
  
  OBJECTIVE
  To describe a case of massive osteolysis of the cervical spine with fatal outcome and to discuss the classification of the disease among osteolysis and its therapeutic modalities.
  
  
  BACKGROUND
  Massive osteolysis is a rare condition (fewer than 100 cases reported in the literature) of unknown etiology, which may involve any bone in the body, with a propensity for the shoulder and pelvic girdle. Few cases of cervical spine involvement were reported.
  
  
  METHODS
  The case of a 32-year-old man with fatal progressive massive osteolysis of the cervical spine despite multiple attempts to achieve surgical stabilization was reported.
  
  
  RESULTS
  Massive osteolysis was characterized by complete destruction of all or part of a bone by angiomatous tissue and may have represented a local disturbance of osteoclastic activity. No successful therapy was proposed, and the prognosis of spine involvement was very poor.
  
  
  CONCLUSIONS
  Massive osteolysis is a rare condition with no successful therapy. The hypothesis of involvement of circulating preosteoclasts in the osteolytic process may suggest treatment attempts with diphosphonates because of the futility of standard bone grafting techniques in spine involvement.
authors.affiliation: Service de Chirurgie Orthopédique, CHU, Hôpital Trousseau, Tours, France.
authors.forename: H
authors.initials: H
authors.lastname: Foult
authors.forename: P
authors.initials: P
authors.lastname: Goupille
authors.forename: B
authors.initials: B
authors.lastname: Aesch
authors.forename: J P
authors.initials: JP
authors.lastname: Valat
authors.forename: P
authors.initials: P
authors.lastname: Burdin
authors.forename: M
authors.initials: M
authors.lastname: Jan
mesh_terms: D000328:Adult; D016025:Bone Transplantation; D002574:Cervical Vertebrae / Q000473:pathology* / Q000601:surgery; D017809:Fatal Outcome; D006801:Humans; D008297:Male; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000601:surgery*; D011859:Radiography