Carbimazole-induced agranulocytosis treated with granulocyte-macrophage colony stimulating factor--a case report.
Drug-induced agranulocytosis is a potentially fatal complication despite advances in supportive care. A patient with carbimazole-induced agranulocytosis associated with marked depletion of granulocytic precursors in the marrow was treated with granulocyte-macrophage colony stimulating factor (GM-CSF) at a dose of 5 micrograms/kg subcutaneously daily for one week. The absolute neutrophil count rose above 1 x 10(9)/L after one week of GM-CSF therapy. The GM-CSF probably expedited the recovery of the neutrophil count. Further studies are warranted to delineate the role of GM-CSF in the treatment of drug-induced agranulocytosis.
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Subang Jaya Medical Centre, Selangor, Malaysia.
D000380:Agranulocytosis / Q000139:chemically induced* / Q000628:therapy*; D002231:Carbimazole / Q000009:adverse effects*; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007958:Leukocyte Count; D008875:Middle Aged; D009504:Neutrophils
D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D002231:Carbimazole