title: Growth fractions (Ki-67) in primary breast cancers, with particular reference to node-negative tumors.
abstract: We determined the growth fraction in 549 primary breast carcinomas using monoclonal antibody Ki-67. With respect to the course of disease, significant differences emerged for the whole collective as well as among the node-positive tumors. We paid special attention to the node-negative (N0) carcinomas in the group, the aim being to differentiate a prognostically unfavorable subgroup in this otherwise favorable collective. Owing to the comparative rarity of clinical events, our findings for such tumors failed to attain statistical significance; however, a strong clinical trend indicating an adverse prognosis for both overall and disease-free survival emerged for tumors exhibiting a high growth fraction. One-quarter of these patients had received adjuvant treatment. In the group exhibiting high levels of Ki-67 reactivity, significantly less favorable findings with respect to overall survival were observed among the untreated patients. The present results seem to confirm previous indications that antibody Ki-67 is of value in assessing the prognosis of N0 breast cancer.
authors.affiliation: Department of Gynecology and Obstetrics, Universitäts-Frauenklinik Mainz, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Weikel
authors.forename: C
authors.initials: C
authors.lastname: Brumm
authors.forename: C
authors.initials: C
authors.lastname: Wilkens
authors.forename: T
authors.initials: T
authors.lastname: Beck
authors.forename: P G
authors.initials: PG
authors.lastname: Knapstein
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality / Q000473:pathology*; D005260:Female; D006801:Humans; D019394:Ki-67 Antigen; D008207:Lymphatic Metastasis; D009363:Neoplasm Proteins / Q000032:analysis*; D009687:Nuclear Proteins / Q000032:analysis*; D015996:Survival Rate
chemical_list: D019394:Ki-67 Antigen; D009363:Neoplasm Proteins; D009687:Nuclear Proteins