[Macular complications of synthetic antimalarials. Apropos of a case].
The clinico-pathological findings in a 17-year-old girl with an "oeil de boeuf" maculopathy are reported together with the aetiological elements involved (hereditary or toxic maculopathy). The case was a second stage typical maculopathy due to antimalarial drugs. These patients were particularly susceptible, probably because of impaired renal function, since the total dose absorbed (140 g. chloroquine) was low. Ophthalmologic monitoring is required to prevent intoxication. Clinical examination, angiography and automatic perimetry and contrast sensitivity test are needed to detect the first effect of toxicity.
Ducousso
F
F
Service d'Ophtalmologie, Hôpital d'Instruction des Armées Robert Picqué, Bordeaux-Armées
Ballion
J C
JC
Kovalski
J L
JL
Labrouze
J M
JM
Bazin
S
S
Bourguignon
G
G
Saliou
G
G
D000293:Adolescent; D000962:Antimalarials / Q000009:adverse effects*; D002738:Chloroquine / Q000009:adverse effects*; D003937:Diagnosis, Differential; D015785:Eye Diseases, Hereditary / Q000175:diagnosis; D005260:Female; D006801:Humans; D008266:Macula Lutea; D012164:Retinal Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000503:physiopathology
D000962:Antimalarials; D002738:Chloroquine
Complications maculaires des antipaludéens de synthèse. A propos d'une observation.