[Assessment of the possibility of using the photodynamic effect in rheumatology].
Results of the analysis of a number of parameters which determine the efficiency of using the photodynamic action for treating rheumatoid arthritis are reported. The investigations are based on determining the character of sensitizer stabilization in the joint tissue and evaluating its stability. As the sensitizer chlorin e6 was chosen. We have established the fact of contrast accumulation of chlorin e6 in the synovial membrane and cartilage, developed the system of intrajoint introduction of the pigment, studied the kinetics of sensitizer destruction under irradiation.
Tauraĭtis
V A
VA
Shishporenok
S I
SI
Grubina
L A
LA
Sarzhevskaia
M V
MV
Gurinovich
I F
IF
GGurinovich
G P
GP
Matulis
A A
AA
D000818:Animals; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D002735:Chlorophyllides; D007596:Joints / Q000378:metabolism / Q000473:pathology; D010778:Photochemotherapy; D011166:Porphyrins / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011817:Rabbits; D011838:Radiation-Sensitizing Agents / Q000493:pharmacokinetics / Q000627:therapeutic use*
D002735:Chlorophyllides; D011166:Porphyrins; D011838:Radiation-Sensitizing Agents; C062985:phytochlorin
Otsenka vozmozhnosti ispol'zovaniia fotodinamicheskogo éffekta v revmatologii.