Oncocytic metaplasia of bile duct epithelium in hepatic GVHD.
A 15-year-old female underwent matched unrelated BMT for chemotherapy resistant ALL. She died 3 months later from septicaemia complicating grade IV GVHD. Light and electron microscopic examination of the post-mortem liver confirmed GVHD and showed oncocytic metaplasia of interlobular bile duct epithelium. We report that oncocytic metaplasia of bile duct epithelium is part of the pathological spectrum of hepatic GVHD.
Bligh
J
J
Department of Pathology, Royal Brisbane Hospital, Herston, Australia.
Morton
J
J
Durrant
S
S
Walker
N
N
D000293:Adolescent; D001652:Bile Ducts / Q000473:pathology*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D004848:Epithelium / Q000473:pathology; D005260:Female; D006086:Graft vs Host Disease / Q000473:pathology*; D006801:Humans; D008107:Liver Diseases / Q000473:pathology*; D008679:Metaplasia