[Kinetics of 7-aminocephalosporanic acid in aqueous solutions].
Stability of 7-aminocephalosporanic acid (7-ACA) and desacetyl-7-ACA in aqueous solutions at the pH value higher than 6 and wide ranges of the temperature was studied. The kinetic parameters of the hydrolysis of the ester link in the molecule of 7-ACA and the openings of the betalactam link in the molecules of 7-ACA and desacetyl-7-ACA were estimated. It was shown that all the destruction processes were describable by the 1st order equations. A procedure for the calculation of the velocity constants of the above mentioned three processes by changes in the concentration of 7-ACA and desacetyl-7-ACA in the solutions is described.
Kurochkina
V B
VB
Larina
E V
EV
Nys
P S
PS
Libinson
G S
GS
D001711:Biotransformation; D002384:Catalysis; D002511:Cephalosporins / Q000493:pharmacokinetics*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D012996:Solutions; D013696:Temperature; D014867:Water / Q000737:chemistry
D002511:Cephalosporins; D012996:Solutions; D014867:Water; C030735:7-aminocephalosporanic acid
Kinetika prevrashchenniĭ 7-aminotsefalosporanovoĭ kisloty v vodnykh rastvorakh.