title: Primary structures and properties of two related forms of aryl sulfotransferases in human liver.
abstract: cDNAs and genes of ST1A2 and ST1A3 section were isolated from human liver cDNA and genomic libraries and shown to encode arylsulfotransferases. Studies on their mRNAs and proteins expressed indicate the existence of two distinct phenol-sulfating enzymes which are involved in the metabolic activation of carcinogenic arylamines in human livers.
authors.affiliation: Department of Pharmacology, School of Medicine, Keio University, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ozawa
authors.forename: K
authors.initials: K
authors.lastname: Nagata
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: M
authors.initials: M
authors.lastname: Ueda
authors.forename: T
authors.initials: T
authors.lastname: Tsuzuki
authors.forename: Y
authors.initials: Y
authors.lastname: Yamazoe
authors.forename: R
authors.initials: R
authors.lastname: Kato
mesh_terms: D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D015239:Arylsulfotransferase / Q000737:chemistry / Q000235:genetics*; D001483:Base Sequence; D001711:Biotransformation; D015152:Blotting, Northern; D002273:Carcinogens / Q000378:metabolism*; D005260:Female; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics*; D008099:Liver / Q000201:enzymology*; D008113:Liver Neoplasms / Q000201:enzymology* / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D005810:Multigene Family; D012689:Sequence Homology, Nucleic Acid
chemical_list: D002273:Carcinogens; D007527:Isoenzymes; D015239:Arylsulfotransferase