title: E6-AP directs the HPV E6-dependent inactivation of p53 and is representative of a family of structurally and functionally related proteins.
authors.affiliation: Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Huibregtse
authors.forename: M
authors.initials: M
authors.lastname: Scheffner
authors.forename: P M
authors.initials: PM
authors.lastname: Howley
mesh_terms: D000595:Amino Acid Sequence; D002460:Cell Line; D004926:Escherichia coli / Q000235:genetics; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000209:etiology / Q000821:virology; D027383:Papillomaviridae / Q000235:genetics / Q000378:metabolism* / Q000472:pathogenicity; D030361:Papillomavirus Infections / Q000209:etiology; D010957:Plasmids; D011993:Recombinant Fusion Proteins / Q000235:genetics / Q000378:metabolism; D017386:Sequence Homology, Amino Acid; D016159:Tumor Suppressor Protein p53 / Q000037:antagonists & inhibitors* / Q000235:genetics; D014412:Tumor Virus Infections / Q000209:etiology; D044767:Ubiquitin-Protein Ligases; D014452:Ubiquitins / Q000378:metabolism; D002583:Uterine Cervical Neoplasms / Q000209:etiology / Q000821:virology; D014764:Viral Proteins / Q000235:genetics / Q000378:metabolism*
chemical_list: D011993:Recombinant Fusion Proteins; D016159:Tumor Suppressor Protein p53; D014452:Ubiquitins; D014764:Viral Proteins; D044767:Ubiquitin-Protein Ligases