Antibacterial activity of flavanostilbenes against methicillin-resistant Staphylococcus aureus.
Three phytochemical compounds (alopecurone A-C), flavanostilbenes which are produced by condensation between a hydroxyflavanone and a hydroxystilbene, were isolated as major components from the root of Sophora alopecuroides. They uniformly inhibited the growth of 21 strains of methicillin-resistant Staphylococcus aureus with minimum inhibitory concentrations of 3.13-6.25 micrograms ml-1.
Sato
M
M
Department of Oral Microbiology, Asahi University School of Dentistry, Gifu, Japan.
Tsuchiya
H
H
Miyazaki
T
T
Ohyama
M
M
Tanaka
T
T
Iinuma
M
M
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D007887:Fabaceae / Q000737:chemistry*; D016106:Methicillin Resistance; D008826:Microbial Sensitivity Tests; D010936:Plant Extracts / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D010946:Plants, Medicinal; D013211:Staphylococcus aureus / Q000187:drug effects* / Q000254:growth & development
D000900:Anti-Bacterial Agents; D010936:Plant Extracts