title: Association of increased bronchoalveolar lavage fluid albumin and serum beta 2-microglobulin with pulmonary complications after allogeneic bone marrow transplantation.
abstract: The aim of this prospective study was to identify markers in bronchoalveolar lavage fluid (BAL fluid) and serum predictive for the development of pulmonary complications in the early phase (< 50 days) post-BMT. Concentrations of BAL fluid albumin (alb) and serum beta 2-microglobulin (S-beta 2m,) were determined 10 days before BMT (BAL-B, baseline) and on day 1 post-BMT (BAL-1) in 20 patients who subsequently developed pulmonary complications (group 1) and in 66 patients who remained free of complications for a minimum of 12 months (group 2). Median BAL fluid alb concentrations were significantly (P < 0.05) higher in group 1 patients as compared to group 2 patients at BAL-B (40 vs 28 mg/l) and at BAL-1 (30 vs 15 mg/l). S-beta 2m at BAL-1 was also significantly elevated in group 1 patients (median 1.3 mg/l) compared to group 2 patients (median 1.15 mg/l). Using cut-off values for BAL fluid alb (> 23 mg/l) and S-beta 2m (> 0.8 mg/l) we identified 12 patients out of 19 who developed subsequent pulmonary complications from 12 out of 62 patients without such complications, 1 day post-BMT.
authors.affiliation: Institut fuer Immunologie, Universitaetsklinikum Essen, Germany.
authors.forename: E
authors.initials: E
authors.lastname: Kreuzfelder
authors.forename: K
authors.initials: K
authors.lastname: Quabeck
authors.forename: M
authors.initials: M
authors.lastname: Braun
authors.forename: W
authors.initials: W
authors.lastname: Weber
authors.forename: U
authors.initials: U
authors.lastname: Westhoff
authors.forename: U W
authors.initials: UW
authors.lastname: Schaefer
authors.forename: J
authors.initials: J
authors.lastname: Bruch
authors.forename: U
authors.initials: U
authors.lastname: Costabel
authors.forename: H
authors.initials: H
authors.lastname: Grosse-Wilde
mesh_terms: D000293:Adolescent; D000328:Adult; D000418:Albumins / Q000032:analysis*; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D005260:Female; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014184:Transplantation, Homologous; D001613:beta 2-Microglobulin / Q000032:analysis*
chemical_list: D000418:Albumins; D001613:beta 2-Microglobulin