title: A reinvestigation of Maprounea triterpenes.
abstract: Anti-HIV activity and the inhibition of phorbol ester receptor binding activity in two species of Maprounea were traced to small amounts of highly potent phorbol esters of the daphnane type. The triterpenes previously isolated from this genus were found to be devoid of biological activity when scrupulously purified. Four new triterpene esters were elucidated; two [3,4] were found in M. africana, while three [4,6,7] were found in M. membranacea. Nmr assignments have also been made for two previously known compounds [2,5] in this group.
authors.affiliation: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Beutler
authors.forename: Y
authors.initials: Y
authors.lastname: Kashman
authors.forename: M
authors.initials: M
authors.lastname: Tischler
authors.forename: J H
authors.initials: JH
authors.lastname: Cardellina
authors.forename: G N
authors.initials: GN
authors.lastname: Gray
authors.forename: M J
authors.initials: MJ
authors.lastname: Currens
authors.forename: M E
authors.initials: ME
authors.lastname: Wall
authors.forename: M C
authors.initials: MC
authors.lastname: Wani
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D000107:Acetylation; D000818:Animals; D001667:Binding, Competitive / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D008401:Gas Chromatography-Mass Spectrometry; D006678:HIV / Q000187:drug effects*; D006868:Hydrolysis; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D015240:Phorbol 12,13-Dibutyrate / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D018894:Reverse Transcriptase Inhibitors; D013045:Species Specificity; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*
chemical_list: D018894:Reverse Transcriptase Inhibitors; D014315:Triterpenes; D015240:Phorbol 12,13-Dibutyrate