title: Cancer incidence after radiotherapy for skin haemangioma during infancy.
abstract: An infant cohort treated for skin haemangioma with 226Ra between 1930 and 1965 (n = 11,807) was studied. The median age at treatment was 5-months and 88% were treated before 12 months of age. This cohort was followed up in the Swedish Cancer Registry during the years 1958 to 1989, giving 370,517 person-years at risk. A total number of 248 malignancies have been observed and the standardized incidence ratio (SIR) was 1.21 (confidence interval (CI) 95%, 1.06-1.37). Significantly increased numbers of cancers were found in the central nervous system, 34 cases (SIR = 1.85, CI 95% 1.28-2.59), the thyroid, 15 cases (SIR = 1.88, CI 95% 1.05-3.09) and other endocrine glands, 23 cases (SIR = 2.58, CI 95% 1.64-3.87). The absorbed dose in 11 specified risk organs has been estimated using a phantom of the size of a 5-6-month-old child. The mean absorbed dose in the thyroid was 0.12 Gy and the excess relative risk (ERR) for thyroid cancer was 7.5 per Gy (CI 95% 0.4-18.1). The mean dose in the central nervous system was 0.077 Gy and the ERR for brain tumours was 10.9 per Gy (CI 95% 3.7-20.5). This cohort gives a unique opportunity to analyse long-term effects of low-dose irradiation during infancy.
authors.affiliation: Department of Oncology and Radiation Physics, Sahlgrenska University Hospital, Göteborg, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Lindberg
authors.forename: P
authors.initials: P
authors.lastname: Karlsson
authors.forename: B
authors.initials: B
authors.lastname: Arvidsson
authors.forename: E
authors.initials: E
authors.lastname: Holmberg
authors.forename: L M
authors.initials: LM
authors.lastname: Lunberg
authors.forename: A
authors.initials: A
authors.lastname: Wallgren
mesh_terms: D000293:Adolescent; D000328:Adult; D001932:Brain Neoplasms / Q000453:epidemiology; D016543:Central Nervous System Neoplasms / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D016001:Confidence Intervals; D004701:Endocrine Gland Neoplasms / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000532:radiotherapy*; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D011883:Radium / Q000009:adverse effects*; D012042:Registries; D012306:Risk; D012878:Skin Neoplasms / Q000532:radiotherapy*; D013548:Sweden / Q000453:epidemiology; D013964:Thyroid Neoplasms / Q000453:epidemiology
chemical_list: D011883:Radium