Transmission of thyrotoxicosis of autoimmune type by sibling allogeneic bone marrow transplant.
This case report is on a 25-year-old male with acute myeloblastic leukaemia who achieved a remission after cytoxic therapy and whole-body irradiation. He received a bone marrow transplant from his human leucocyte antigen (HLA)-identical sister who had unsuspected autoimmune thyroid disease. Nine months later the bone marrow recipient developed thyrotoxicosis of autoimmune type at a time when his circulating lymphocytes were of 46XX karyotype. It is suspected that the thyrotoxicosis resulted from the transplantation of a clone of lymphocytes predisposed to the production of thyroid-stimulating autoantibodies.
Thomson
J A
JA
University Department of Medicine, Glasgow Royal Infirmary, UK.
Wilson
R M
RM
Franklin
I M
IM
D000328:Adult; D001323:Autoantibodies / Q000378:metabolism; D001327:Autoimmune Diseases / Q000209:etiology* / Q000235:genetics* / Q000276:immunology; D016026:Bone Marrow Transplantation / Q000009:adverse effects* / Q000276:immunology; D005192:Family Health; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics / Q000628:therapy; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D011863:Radioimmunoassay; D013967:Thyroiditis, Autoimmune / Q000235:genetics / Q000276:immunology; D013971:Thyrotoxicosis / Q000209:etiology* / Q000235:genetics* / Q000276:immunology; D014184:Transplantation, Homologous
D001323:Autoantibodies