title: Hemorrheologic effects of metabolites of pentoxifylline (Trental).
abstract: Pentoxifylline (Trental) is metabolized by red blood cells and the liver into seven metabolites. Metabolites I and V have significant hemorrheologic effects. They are both similar to pentoxifylline in their activity on red blood cell membrane fluidity. Metabolite I is more active than pentoxifylline in inhibiting ADP-induced platelet aggregation. Metabolite V is more active than pentoxifylline in inhibiting epinephrine-induced platelet aggregation.
authors.affiliation: Department of Internal Medicine, State University of New York at Buffalo, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Ambrus
authors.forename: S
authors.initials: S
authors.lastname: Stadler
authors.forename: M
authors.initials: M
authors.lastname: Kulaylat
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology; D004837:Epinephrine / Q000494:pharmacology; D004907:Erythrocyte Deformability; D004910:Erythrocyte Membrane / Q000502:physiology; D004912:Erythrocytes / Q000378:metabolism; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008560:Membrane Fluidity; D010431:Pentoxifylline / Q000378:metabolism*; D010974:Platelet Aggregation / Q000187:drug effects
chemical_list: D000244:Adenosine Diphosphate; D010431:Pentoxifylline; D004837:Epinephrine