Intracellular regulation. Rac and Bcr regulate phagocytic phoxes.
The NADPH oxidase of phagocytes is essential for defence against invading microorganisms. The small GTpase Rac seems to be critical for the activation and deactivation of the phox proteins that make up this enzyme.
Ridley
A J
AJ
Ludwig Institute for Cancer Research, University College School of Medicine, London, UK.
D000818:Animals; D004789:Enzyme Activation; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006801:Humans; D009247:NADH, NADPH Oxidoreductases / Q000378:metabolism*; D019255:NADPH Oxidases; D015513:Oncogene Proteins / Q000378:metabolism*; D010586:Phagocytes / Q000201:enzymology*; D010750:Phosphoproteins / Q000378:metabolism; D011505:Protein-Tyrosine Kinases; D011518:Proto-Oncogene Proteins; D051562:Proto-Oncogene Proteins c-bcr; D020744:rac GTP-Binding Proteins
D015513:Oncogene Proteins; D010750:Phosphoproteins; D011518:Proto-Oncogene Proteins; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases; D011505:Protein-Tyrosine Kinases; C496613:BCR protein, human; D051562:Proto-Oncogene Proteins c-bcr; D019204:GTP-Binding Proteins; D020744:rac GTP-Binding Proteins