[The stimulating effect of sialic acid on the processes of postradiation hemopoietic regeneration].
The possibility of stimulating hemopoiesis inhibited by irradiation with N-acetylneuraminic acid (N-ANA) and the mechanisms of this stimulating effect are considered. A 3-fold N-ANA injection (total dose 150 mg/kg) on days 3, 4, and 5 after irradiation mainly promote the activation of erythropoiesis in the bone marrow. A reliable increase in the amount of erythrokaryocytes in the bone marrow and erythroid colony formation from erythroid precursors (CFU-E) were observed in mice CBA irradiated in a dose of 2.0 g and then received N-ANA. A rise in erythropoietic activity production by bone marrow cells testified that elevation of hemopoiesis inducing microenvironment function is the base of stimulating effect of N-ANA on hemopoiesis.
Agafonov
V I
VI
Dygaĭ
A M
AM
Boldyshev
D A
DA
Khlusov
I A
IA
Gol'dberg
E D
ED
D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects / Q000528:radiation effects; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells; D003114:Colony-Forming Units Assay; D006410:Hematopoiesis / Q000187:drug effects* / Q000528:radiation effects*; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D019158:N-Acetylneuraminic Acid; D012794:Sialic Acids / Q000494:pharmacology*; D013268:Stimulation, Chemical; D013997:Time Factors; D014916:Whole-Body Irradiation
D012794:Sialic Acids; D019158:N-Acetylneuraminic Acid
O stimuliruiushchem vliianii sialovoĭ kisloty na protsessy postluchevoĭ regeneratsii gemopoéza.