Effect of domoic acid on brain amino acid levels.
The administration of Domoic Acid (Dom) in a 0.2 mg/kg i.p. dose induces changes in the levels of amino acids of neurochemical interest (Asp, Glu, Gly, Tau, Ala, GABA) in different rat brain regions (hypothalamus, hippocampus, amygdala, striatum, cortex and midbrain). The most affected amino acid is the GABA, the main inhibitory amino acid neurotransmitter, whereas glutamate, the main excitatory amino acid, is not affected. The rat brain regions that seem to be the main target of the Dom action belong to the limbic system (hippocampus, amygdala). The possible implication of the amino acids in the actions of Dom is also discussed.
Durán
R
R
Departamento de Biología Fundamental, Facultad de Ciencias, Universidad de Vigo, Spain.
Arufe
M C
MC
Arias
B
B
Alfonso
M
M
D000596:Amino Acids / Q000032:analysis* / Q000187:drug effects*; D000818:Animals; D001224:Aspartic Acid / Q000032:analysis; D001923:Brain Chemistry / Q000187:drug effects*; D002851:Chromatography, High Pressure Liquid; D007608:Kainic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D009467:Neuromuscular Depolarizing Agents / Q000494:pharmacology*; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000032:analysis
D000596:Amino Acids; D009467:Neuromuscular Depolarizing Agents; D001224:Aspartic Acid; D005680:gamma-Aminobutyric Acid; C012301:domoic acid; D007608:Kainic Acid