title: A family of murine NK cell receptors specific for target cell MHC class I molecules.
abstract: The Ly-49A molecule is an NK cell receptor specific for MHC class I molecules on target cells. When Ly-49A engages H-2Dd, Ly-49A+ NK cells become globally incapable of killing their targets in vitro. This interaction also occurs in vivo. Ly-49A belongs to a family of highly related molecules, including Ly-49C (5E6 antigen) and LGL-1 that also determine NK cell specificity. In the NK gene complex, the Ly-49 family is genetically linked to genes encoding NKR-P1 and CD69 that are structurally related and capable of activating NK cells. Finally, Ly-49 may be related to human molecules that are selectively expressed on NK cells and influence NK cell specificity. These findings highlight the emerging significance of the Ly-49 family in NK cell activity.
authors.affiliation: Howard Hughes Medical Institute, Department of Medicine, Mount Sinai Medical Center, New York 10029, USA.
authors.forename: W M
authors.initials: WM
authors.lastname: Yokoyama
authors.forename: B F
authors.initials: BF
authors.lastname: Daniels
authors.forename: W E
authors.initials: WE
authors.lastname: Seaman
authors.forename: R
authors.initials: R
authors.lastname: Hunziker
authors.forename: D H
authors.initials: DH
authors.lastname: Margulies
authors.forename: H R
authors.initials: HR
authors.lastname: Smith
mesh_terms: D000818:Animals; D000950:Antigens, Ly; D000954:Antigens, Surface / Q000378:metabolism*; D000939:Epitopes / Q000378:metabolism*; D005805:Genes, MHC Class I / Q000276:immunology*; D007694:Killer Cells, Natural / Q000378:metabolism*; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins / Q000235:genetics*; D051379:Mice; D011971:Receptors, Immunologic / Q000235:genetics*; D055630:Receptors, NK Cell Lectin-Like
chemical_list: D000950:Antigens, Ly; D000954:Antigens, Surface; D000939:Epitopes; D037181:Lectins, C-Type; D008562:Membrane Glycoproteins; D011971:Receptors, Immunologic; D055630:Receptors, NK Cell Lectin-Like