title: Molecular chaperones. Resurrection or destruction?
abstract: Recent studies implicate Hsp104/Clp family chaperones in both protein disaggregation and protein degradation. How do these homologous ring-shaped complexes function in such different ways?
authors.affiliation: Department of Genetics and HHMI, Boyer Centre, New Haven, Connecticut 06510, USA.
authors.forename: A L
authors.initials: AL
authors.lastname: Horwich
mesh_terms: D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D006360:Heat-Shock Proteins / Q000502:physiology; D018832:Molecular Chaperones / Q000502:physiology*; D011506:Proteins / Q000378:metabolism*; D029701:Saccharomyces cerevisiae Proteins; D013329:Structure-Activity Relationship
chemical_list: D006360:Heat-Shock Proteins; D018832:Molecular Chaperones; D011506:Proteins; D029701:Saccharomyces cerevisiae Proteins; C070972:HsP104 protein, S cerevisiae; D000251:Adenosine Triphosphatases