Lack of association between HLA class II polymorphisms and essential hypertension in a Belgian population.
The aim of the present study was to investigate whether the HLA class II polymorphisms contributes to the susceptibility to essential hypertension in the Belgian population. For this purpose we studied 120 hypertensive patients and 168 normotensive controls by means of a PCR-SSO assay. No significant difference in allele and genotype frequencies of the DRB and DPB1 loci could be found between the two groups. We concluded that essential hypertension as a multifactorial and heterogeneous disease cannot be associated with one of the HLA class II DRB and DPB1 alleles in Belgian patients.
Gu
X X
XX
Center for Human Genetics, University of Leuven, Belgium.
Spaepen
M
M
Raeymaekers
P
P
Guo
C
C
Fagard
R
R
Amery
A
A
Lijnen
P
P
Cassiman
J J
JJ
D000328:Adult; D000368:Aged; D000483:Alleles; D001483:Base Sequence; D005260:Female; D005838:Genotype; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D006973:Hypertension / Q000235:genetics* / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D015335:Molecular Probes / Q000235:genetics; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic
D000949:Histocompatibility Antigens Class II; D015335:Molecular Probes