Fatal illness associated with a new hantavirus in Louisiana.
A fatal case of hantaviral illness occurred in Louisiana, outside of the range of P. maniculatus, the rodent reservoir for Sin Nombre virus. Hantavirus RNA and antigens were detected in patient autopsy tissues, and nucleotide sequence analysis of amplified polymerase chain reaction (PCR) products identified a newly recognized unique hantavirus, provisionally named Bayou virus. Prominent features of the clinical illness are compatible with hantavirus pulmonary syndrome (HPS), but several features such as renal insufficiency and intraalveolar hemorrhage are more compatible with hemorrhagic fever with renal syndrome (HFRS), a disease associated with Eurasian hantaviruses.
Khan
A S
AS
Division of Viral and Rickettsial Diseases, Centers for Disease Control and Prevention, Atlanta GA 30333, USA.
Spiropoulou
C F
CF
Morzunov
S
S
Zaki
S R
SR
Kohn
M A
MA
Nawas
S R
SR
McFarland
L
L
Nichol
S T
ST
D000956:Antigens, Viral / Q000276:immunology; D001483:Base Sequence; D017809:Fatal Outcome; D006476:Orthohantavirus / Q000145:classification / Q000235:genetics / Q000276:immunology / Q000302:isolation & purification*; D018778:Hantavirus Infections / Q000276:immunology / Q000503:physiopathology / Q000821:virology*; D006801:Humans; D007150:Immunohistochemistry; D008145:Louisiana; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D010802:Phylogeny; D016133:Polymerase Chain Reaction; D012367:RNA, Viral / Q000032:analysis
D000956:Antigens, Viral; D012367:RNA, Viral