title: O'Brien's actinic granuloma: response to isotretinoin.
abstract: We describe a 75-year-old man demonstrating the florid clinical features of actinic granuloma of O'Brien. This rare disfiguring condition is believed to result from a granulomatous reaction of the dermis to solar-induced elastosis and is poorly responsive to topical steroids. Twelve weeks' treatment with isotretinoin prevented the development of new granulomata and produced almost complete resolution of established lesions.
authors.affiliation: Department of Dermatology, Addenbrooke's Hospital, Cambridge, UK.
authors.forename: R C
authors.initials: RC
authors.lastname: Ratnavel
authors.forename: J W
authors.initials: JW
authors.lastname: Grant
authors.forename: S E
authors.initials: SE
authors.lastname: Handfield-Jones
authors.forename: P G
authors.initials: PG
authors.lastname: Norris
mesh_terms: D000368:Aged; D005148:Facial Dermatoses / Q000188:drug therapy*; D006099:Granuloma / Q000188:drug therapy*; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008297:Male; D009333:Neck; D012871:Skin Diseases / Q000188:drug therapy*
chemical_list: D007641:Keratolytic Agents; D015474:Isotretinoin