title: Presurgical assessment and therapy of microinvasive carcinoma of the cervix.
abstract: Retrievable pathological specimens and clinical data on 70 patients with microinvasive carcinoma diagnosed on surgical specimens from cone biopsy or hysterectomy (Stage IA) were reviewed and compared to pertinent findings in the literature with the intent of evaluating diagnostic criteria and defining pathological features that may influence the outcome by therapy. Emphasis was given to the preoperative assessment emphasizing that both an accurate colposcopic evaluation and a detailed pathological analysis may reliably point to a conservative therapeutic approach. Increasing depth of stromal invasion was associated with lesion width as well as with endocervical extension, as measured on colposcopy, microcolpohisteroscopy, and histology. Lymph-vascular space involvement was significantly related to depth of invasion. Two patients of 28 with dissected nodes had node metastases as well as lymph-vascular space involvement. Both developed a pelvic recurrence. One had a > 1- to < or = 3-mm invasion depth, the other a > 3- to < or = 5-mm lesion invasion. While advocating a conservative procedure for Stage IA1, we suggest discrimination with regard to Stage IA2 because we believe that lymph-vascular involvement should be meticulously evaluated. In fact, > 1- to < or = 3-mm lesions without lymph-vascular space involvement can be conservatively treated, while for any other lesion falling within the Stage IA2 category a modified radical histerectomy plus pelvic lymphadenectomy should be recommended.
authors.affiliation: II Department of Obstetrics and Gynecology, University of Bologna, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Orlandi
authors.forename: S
authors.initials: S
authors.lastname: Costa
authors.forename: P
authors.initials: P
authors.lastname: Terzano
authors.forename: G N
authors.initials: GN
authors.lastname: Martinelli
authors.forename: G
authors.initials: G
authors.lastname: Comerci
authors.forename: B
authors.initials: B
authors.lastname: Guerra
authors.forename: L
authors.initials: L
authors.lastname: Martellini
mesh_terms: D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000473:pathology* / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D011300:Preoperative Care; D002583:Uterine Cervical Neoplasms / Q000473:pathology* / Q000628:therapy