Serum concentrations of IL-5, GM-CSF, and IL-3 and the production by lymphocytes in various eosinophilia.
The concentrations of interleukin-5 (IL-5), granulocyte-macrophage colony-stimulating factor GM-CSF, and interleukin-3 (IL-3) in serum and in IL-2-stimulated lymphocyte culture medium (L-IL2-CM) prepared from patients with reactive eosinophilia were measured by enzyme-linked immunosorbent assay (ELISA). Serum IL-5 levels were increased in 16 out of 42 cases. GM-CSF and IL-3 were below the detectable levels in all sera examined. The concentrations of IL-5 and GM-CSF in L-IL2-CM were increased in 10 out of 29 patients. IL-3 was below the detectable levels in all L-IL2-CM.
Koike
T
T
Third Department of Internal Medicine, Dokkyo University School of Medicine, Tochigi, Japan.
Enokihara
H
H
Arimura
H
H
Ninomiya
H
H
Yamashiro
K
K
Tsuruoka
N
N
Tsujimoto
M
M
Aoyagi
M
M
Watanabe
K
K
Nakamura
Y
Y
D000799:Angioedema / Q000097:blood; D000796:Angiolymphoid Hyperplasia with Eosinophilia / Q000097:blood; D002478:Cells, Cultured; D017077:Culture Media, Conditioned; D004797:Enzyme-Linked Immunosorbent Assay; D004802:Eosinophilia / Q000097:blood*; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000378:metabolism*; D006410:Hematopoiesis; D006801:Humans; D017681:Hypereosinophilic Syndrome / Q000097:blood; D007377:Interleukin-3 / Q000378:metabolism*; D015848:Interleukin-5 / Q000378:metabolism*; D008214:Lymphocytes / Q000166:cytology*
D017077:Culture Media, Conditioned; D007377:Interleukin-3; D015848:Interleukin-5; D016178:Granulocyte-Macrophage Colony-Stimulating Factor