title: Polyserositis in a patient with acute paracoccidioidomycosis and hepatosplenic schistosomiasis.
abstract: A severe case of juvenile paracoccidioidomycosis (PCM), manifested as cholestatic jaundice, lymph node enlargement and an unusual form of polyserositis, associated with portal hypertension secondary to schistosomiasis, as well as bacteremias caused by E. coli and S. aureus and post-transfusional hepatitis C is reported. Temporary unresponsiveness of in vivo and in vitro cellular immune responses to P. brasiliensis were registered. The authors discuss the possible interference of either agent in the host immune response, thus explaining the severity of PCM in the present case.
authors.affiliation: Laboratório Investigação Médica em Immunologia, Hospital das Clínicas, Faculdade de Medicina da USP, Brazil.
authors.forename: M A
authors.initials: MA
authors.lastname: Shikanai-Yasuda
authors.forename: G
authors.initials: G
authors.lastname: Benard
authors.forename: M I
authors.initials: MI
authors.lastname: Duarte
authors.forename: O H
authors.initials: OH
authors.lastname: Leite
authors.forename: M
authors.initials: M
authors.lastname: Eira
authors.forename: M J
authors.initials: MJ
authors.lastname: Mendes-Giannini
mesh_terms: D000208:Acute Disease; D000328:Adult; D016470:Bacteremia / Q000150:complications; D004927:Escherichia coli Infections / Q000150:complications; D006526:Hepatitis C / Q000150:complications; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications; D007108:Immune Tolerance; D008297:Male; D010229:Paracoccidioidomycosis / Q000150:complications* / Q000276:immunology; D012552:Schistosomiasis / Q000150:complications* / Q000276:immunology; D012700:Serositis / Q000150:complications*; D013203:Staphylococcal Infections / Q000150:complications