title: Mallory-Weiss syndrome in a patient with hemophilia A and chronic liver disease.
abstract: Eighty percent of hemophiliacs exposed to plasma products are seropositive to hepatitis B and an even higher percentage are seropositive to hepatitis C. Post-transfusion hepatitis is followed by cirrhosis in up to 25% of the cases. In the wake of portal hypertension, the development of oesophageal varices entails the risk of life-threatening hemorrhage. We report on a patient with moderate hemophilia A (factor VIII:C 4-11%) who suffered from massive hematemesis, melaena and evolving shock after excessive alcohol ingestion. The diagnosis of Mallory-Weiss syndrome and the differential diagnosis of bleeding oesophageal varices as well as prognostic consequences are discussed.
authors.affiliation: Universitäts Klinik für Anästhesie und Allgemeine Intensivmedizin, Innsbruck, Austria.
authors.forename: E
authors.initials: E
authors.lastname: Ladner
authors.forename: C
authors.initials: C
authors.lastname: Pechlaner
authors.forename: A
authors.initials: A
authors.lastname: Mayr
authors.forename: M
authors.initials: M
authors.lastname: Mörtl
authors.forename: A
authors.initials: A
authors.lastname: Propst
mesh_terms: D000328:Adult; D002908:Chronic Disease; D003937:Diagnosis, Differential; D006471:Gastrointestinal Hemorrhage / Q000209:etiology; D006467:Hemophilia A / Q000150:complications*; D006801:Humans; D008107:Liver Diseases / Q000150:complications* / Q000175:diagnosis; D008297:Male; D008309:Mallory-Weiss Syndrome / Q000150:complications / Q000175:diagnosis*