Spectral indices of cardiovascular adaptations to short-term simulated microgravity exposure.
We investigated the effects of exposure to microgravity on the baseline autonomic balance in cardiovascular regulation using spectral analysis of cardiovascular variables measured during supine rest. Heart rate, arterial pressure, radial flow, thoracic fluid impedance and central venous pressure were recorded from nine volunteers before and after simulated microgravity, produced by 20 hours of 6 degrees head down bedrest plus furosemide. Spectral powers increased after simulated microgravity in the low frequency region (centered at about 0.03 Hz) in arterial pressure, heart rate and radial flow, and decreased in the respiratory frequency region (centered at about 0.25 Hz) in heart rate. Reduced heart rate power in the respiratory frequency region indicates reduced parasympathetic influence on the heart. A concurrent increase in the low frequency power in arterial pressure, heart rate, and radial flow indicates increased sympathetic influence. These results suggest that the baseline autonomic balance in cardiovascular regulation is shifted towards increased sympathetic and decreased parasympathetic influence after exposure to short-term simulated microgravity.
Patwardhan
A R
AR
Center for Biomedical Engineering, University of KY, Lexington 40506-0070, USA.
Evans
J M
JM
Berk
M
M
Grande
K J
KJ
Charles
J B
JB
Knapp
C F
CF
D000222:Adaptation, Physiological / Q000502:physiology*; D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D004231:Diuresis / Q000502:physiology; D005583:Fourier Analysis; D018475:Head-Down Tilt / Q000502:physiology; D006339:Heart Rate / Q000502:physiology; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic / Q000295:instrumentation*; D010275:Parasympathetic Nervous System / Q000502:physiology; D012815:Signal Processing, Computer-Assisted; D013564:Sympathetic Nervous System / Q000502:physiology; D014882:Water-Electrolyte Balance / Q000502:physiology; D014893:Weightlessness