title: Interferon or hepatitis C virus induced autoimmune aplastic anemia and severe thrombocytopenia? A case report.
abstract: We describe a case of aplastic anemia with severe thrombocytopenia in a patient affected by chronic active hepatitis C treated with interferon. The hematologic alterations did not disappear after suspension of interferon or after the ensuing steroid treatment. Administration of cyclosporin markedly improved the hematologic parameters and serum transaminase levels.
authors.affiliation: Istituto di Medicina Interna e Geriatria, Università degli Studi di Catania.
authors.forename: R
authors.initials: R
authors.lastname: Siciliano
authors.forename: B A
authors.initials: BA
authors.lastname: Trovato
authors.forename: G
authors.initials: G
authors.lastname: Seminara
authors.forename: V
authors.initials: V
authors.lastname: Giustolisi
authors.forename: M
authors.initials: M
authors.lastname: Malaguarnera
mesh_terms: D000741:Anemia, Aplastic / Q000175:diagnosis / Q000209:etiology*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000209:etiology*; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects*; D008875:Middle Aged; D011994:Recombinant Proteins; D013921:Thrombocytopenia / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors
chemical_list: D007370:Interferon Type I; D011994:Recombinant Proteins