title: Pharmacokinetics of fluconazole after oral administration in children with human immunodeficiency virus infection.
abstract: The objective of this study was to determine the pharmacokinetics of fluconazole after oral administration in children with human immunodeficiency virus (HIV) infection. After an overnight fast, a single dose of either 2 mg.kg-1 or 8 mg.kg-1 was administered in a suspension; five children received 2 mg.kg-1 and four 8 mg.kg-1 (ages 5-13 years). Blood samples were collected at various times on day 1, and once daily on days 2-7 after the dose. Fluconazole serum concentrations were measured by gas chromatography. At the dose of 2 mg.kg-1, the Cmax, AUC (0-infinity), and t1/2 ranged from 2.3-4.4 micrograms.ml-1, 84.9-136 micrograms.h.ml-1, and 19.8-34.8 h, respectively. At the dose of 8 mg.kg-1 the Cmax, AUC (0-infinity), and t1/2 ranged from 5.4-12.1 micrograms.ml-1, 330-684 micrograms h.ml-1, and 25.6-42.3 h, respectively. When compared with published data in healthy adults, fluconazole achieved similar serum concentrations in the present group of children, indicating a nearly complete degree of absorption.
authors.affiliation: College of Pharmacy, Ohio State University, Wexner Institute for Pediatric Research, Children's Hospital, Columbus 43210, USA.
authors.forename: M C
authors.initials: MC
authors.lastname: Nahata
authors.forename: M T
authors.initials: MT
authors.lastname: Brady
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D005260:Female; D015725:Fluconazole / Q000493:pharmacokinetics*; D006678:HIV; D006801:Humans; D008297:Male; D010599:Pharmacokinetics; D013997:Time Factors
chemical_list: D015725:Fluconazole