Pregnancy in an azoospermic patient with markedly elevated serum follicle-stimulating hormone levels.
OBJECTIVE
To assess the possibility of achieving a pregnancy in an azoospermic patient with markedly elevated serum FSH level.


METHODS
A case report.


METHODS
In vitro fertilization program at the Instituto Valenciano de Infertilidad.


METHODS
An azoospermic patient with small testes and serum FSH level (38.7 mIU/mL) higher than three times normal. Testicular biopsy revealed Sertoli cell-only syndrome with focal spermatogenesis.


METHODS
Intracytoplasmic microinjection of testicular tissue-extracted spermatozoa.


METHODS
Fertilization rate, cleavage rate, clinical pregnancy.


RESULTS
Eight of 11 (73%) intact oocytes showed two pronuclei. All of them cleaved normally. Four embryos were replaced into the uterine cavity and the other four were cryopreserved. A twin clinical pregnancy was achieved.


CONCLUSIONS
Spermatozoa may be present in testicular biopsy specimens of azoospermic patients with severe spermatogenic failure despite markedly elevated serum FSH level. These patients can be fertile after intracytoplasmic testicular sperm microinjection.
Gil-Salom
M
M
Instituto Valenciano de Infertilidad, Valencia, Spain.
Remohí
J
J
Mínguez
Y
Y
Rubio
C
C
Pellicer
A
A
D000328:Adult; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods*; D005640:Follicle Stimulating Hormone / Q000097:blood*; D006801:Humans; D008297:Male; D008845:Microinjections; D009845:Oligospermia / Q000097:blood* / Q000473:pathology; D009865:Oocytes / Q000648:ultrastructure; D011247:Pregnancy; D012708:Sertoli Cells / Q000473:pathology; D013094:Spermatozoa; D013737:Testis / Q000473:pathology
D005640:Follicle Stimulating Hormone