Changes in the fatty acid profile of plasma and adipose tissue in rats after long-term ethanol feeding.
The effect of chronic ethanol feeding on the fatty acid composition of plasma and abdominal adipose tissue in rats was studied. Animals were maintained on a 30% ethanol solution in drinking water for 3 and 5 months. Control rats were given water. Caloric intake was similar in control and ethanol-fed rats at the end of the experimental period. However, a decrease in body weight was observed in rats that had consumed ethanol. Palmitoleic (16:1n7) and oleic (18:1n9) acids increased markedly, and linoleic acid (18:2n6) decreased in the plasma and in the adipose tissue of ethanol-fed rats with respect to control rats. After 3 months of ethanol ingestion, long-chain polyunsaturated fatty acids were reduced both in plasma and adipose tissue. When ethanol was administered for 5 months, only plasma long-chain polyunsaturated fatty acids of the n-3 series were decreased. This suggest that changes induced by ethanol ingestion in essential fatty acid metabolism is less pronounced when ethanol feeding is maintained for a long period of time.
Gómez-Tubío
A
A
Department of Physiology and Animal Biology, Facultad de Farmacia, Universidad de Sevilla, Spain.
Pita
M L
ML
Tavares
E
E
Murillo
M L
ML
Delgado
M J
MJ
Carreras
O
O
D000273:Adipose Tissue / Q000378:metabolism*; D000437:Alcoholism / Q000097:blood*; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D002149:Energy Intake / Q000502:physiology; D000431:Ethanol / Q000633:toxicity; D005227:Fatty Acids / Q000097:blood*; D005228:Fatty Acids, Essential / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D005227:Fatty Acids; D005228:Fatty Acids, Essential; D015525:Fatty Acids, Omega-3; D000431:Ethanol