Effect of combined atenolol and nifedipine administration on psychomotor performance in normal subjects.
The aim of the present study was to evaluate the central effects of single doses of the beta-adrenoceptor antagonist atenolol and the calcium antagonist nifedipine retard, alone and in combination, in normal subjects. Twelve normal males received single oral doses of atenolol 100 mg, nifedipine retard 20 mg, atenolol 100 mg and nifedipine retard 20 mg in combination, diazepam 5 mg (active control), and each of two matching placebos in a double-blind, randomised fashion. Psychomotor performance was assessed using digit symbol substitution, letter cancellation (LCT), continuous attention, choice reaction time, finger tapping, immediate recall and short-term memory. Two flash fusion and critical flicker fusion thresholds were measured and subjective assessments made using visual analogue scales (VAS). Diazepam 5 mg significantly worsened LCT scores at 4h, significantly impaired alertness at 2 h and 4 h, and tended to increase reaction time and impair continuous attention and physiological measurements. Atenolol 100 mg alone significantly reduced alertness at 2 h and 4 h, and also tended to impair physiological measurements. Nifedipine retard 20 mg produced no significant psychomotor effects. Combined atenolol and nifedipine retard administration produced a small but significant improvement in continuous attention and a reduction in body sway, with no adverse effects being evident on performance or subjective awareness. The results suggest that no significant adverse effects on psychomotor performance are produced by single doses of atenolol 100 mg and nifedipine retard 20 mg when given together in normal subjects.(ABSTRACT TRUNCATED AT 250 WORDS)
Gerrard
L
L
University Department of Clinical Pharmacology, Ninewells Hospital & Medical School, Dundee, Scotland, UK.
Wheeldon
N M
NM
McDevitt
D G
DG
D000284:Administration, Oral; D000328:Adult; D001262:Atenolol / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004338:Drug Combinations; D006801:Humans; D008297:Male; D008570:Memory, Short-Term / Q000187:drug effects; D009543:Nifedipine / Q000494:pharmacology*; D015990:Placebo Effect; D011597:Psychomotor Performance / Q000187:drug effects*; D014838:Volunteers
D004338:Drug Combinations; D001262:Atenolol; D009543:Nifedipine