title: Human glutathione S-transferase M1 null genotype is associated with a high inducibility of cytochrome P450 1A1 gene transcription.
abstract: We investigated the transcriptional regulation of cytochrome P450 1A1 (CYP1A1) gene in human lymphoblastoid B cells and report that a high inducibility of CYP1A1 gene transcription by 2,3,7,8-tetrachlorodibenzo-p-dioxin is associated with glutathione S-transferase M1 (GSTM1) null genotype, whereas the presence of at least one GSTM1 allele is correlated with induction of only low levels of CYP1A1 mRNA by 2,3,7,8-tetrachlorodibenzo-p-dioxin. These data underline the major importance of the CYP1A1 inducibility phenotype associated with the homozygous GSTM1 null genotype in chemically induced cancers.
authors.affiliation: Institut Jacques Monod, Centre National de la Recherche Scientifique, Paris, France.
authors.forename: C
authors.initials: C
authors.lastname: Vaury
authors.forename: R
authors.initials: R
authors.lastname: Lainé
authors.forename: P
authors.initials: P
authors.lastname: Noguiez
authors.forename: P
authors.initials: P
authors.lastname: de Coppet
authors.forename: C
authors.initials: C
authors.lastname: Jaulin
authors.forename: F
authors.initials: F
authors.lastname: Praz
authors.forename: D
authors.initials: D
authors.lastname: Pompon
authors.forename: M
authors.initials: M
authors.lastname: Amor-Guéret
mesh_terms: D001483:Base Sequence; D002461:Cell Line, Transformed; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics / Q000378:metabolism*; D017931:DNA Primers / Q000737:chemistry; D004790:Enzyme Induction / Q000187:drug effects; D015971:Gene Expression Regulation, Enzymologic; D005838:Genotype; D005982:Glutathione Transferase / Q000235:genetics*; D006801:Humans; D016393:Lymphoma, B-Cell / Q000201:enzymology; D008969:Molecular Sequence Data; D000072317:Polychlorinated Dibenzodioxins / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D017931:DNA Primers; D000072317:Polychlorinated Dibenzodioxins; D003577:Cytochrome P-450 Enzyme System; D005982:Glutathione Transferase