Monoisoamyl and mono-n-hexyl meso-2,3-dimercaptosuccinate in mobilizing 203Hg retention in relation to age of rats and route of administration.
Monoisoamyl (Mi-ADMS) and mono-n-hexyl (Mn-HDMS) monoesters of meso-2,3-dimercaptosuccinic acid (DMSA) were given orally or parenterally for the mobilization of inorganic mercury in suckling and older rats. Chelators were administered at a dose of 2 x 0.5 mmol kg-1 on two consecutive days 2 weeks after a single 203Hg injection. Six days later, whole-body, kidney, liver and brain radioactivities were determined in gamma scintillation counters. Both Mi-ADMS and Mn-HDMS were found to be superior to DMSA in mobilizing mercury from body and organs. The results were similar after oral or parenteral treatment. The efficiency of both monoesters was even higher in younger than in older rats. This is the first report on the mobilization of mercury from the body of sucklings under conditions of late oral treatment.
Kostial
K
K
Department of Mineral Metabolism, Institute for Medical Research and Occupational Health, Zagreb, Croatia.
Blanusa
M
M
Piasek
M
M
Prester
L
L
Jones
M M
MM
Singh
P K
PK
D000284:Administration, Oral; D000375:Aging / Q000378:metabolism; D000704:Analysis of Variance; D000818:Animals; D000833:Animals, Suckling; D001822:Body Burden; D001921:Brain / Q000378:metabolism; D002614:Chelating Agents / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004952:Esters; D005260:Female; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D008628:Mercury / Q000378:metabolism*; D008630:Mercury Poisoning / Q000188:drug therapy*; D008631:Mercury Radioisotopes; D011897:Random Allocation; D051381:Rats; D004113:Succimer / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use*
D002614:Chelating Agents; D004952:Esters; D008631:Mercury Radioisotopes; C095859:monohexyl 2,3-dimercaptosuccinate; C091888:monoisoamyl-2,3-dimercaptosuccinate; D004113:Succimer; D008628:Mercury