Reliable preparation of 99mTc (V) DMSA by a simple modified method using a commercial kit for 99mTc (III) DMSA.
99mTc pentavalent dimercaptosuccinic acid [99mTc (V) DMSA], a useful agent for imaging thyroid medullary carcinoma and other tumors, can be reliably prepared by addition of NaHCO3 and then Na99mTcO4 to a commercial kit for 99mTc trivalent DMSA [99mTc (III) DMSA], followed by bubbling oxygen through the solution for 10 min. 99mTc (V) DMSA made by this method is radiochemically pure and stable for 24 h, and it gives a rat biodistribution similar to that of the agent made by previous methods. Clinical biodistribution and radiation dosimetry studies are planned.
Washburn
L C
LC
Department of Radiology, University of Cincinnati Hospital, OH 45267, USA.
Biniakiewicz
D S
DS
Maxon
H R
HR
D000818:Animals; D002855:Chromatography, Thin Layer; D007275:Injections, Intravenous; D007553:Isotope Labeling; D008297:Male; D015609:Organotechnetium Compounds / Q000138:chemical synthesis* / Q000737:chemistry; D011786:Quality Control; D051381:Rats; D017208:Rats, Wistar; D011933:Reagent Kits, Diagnostic; D004113:Succimer / Q000138:chemical synthesis* / Q000737:chemistry; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D014018:Tissue Distribution
D015609:Organotechnetium Compounds; D011933:Reagent Kits, Diagnostic; D019783:Technetium Tc 99m Dimercaptosuccinic Acid; D004113:Succimer