title: Hemimasticatory spasm in hemifacial atrophy: diagnostic and therapeutic aspects in two patients.
abstract: We report two cases of hemimasticatory spasm in association with progressive hemifacial atrophy. On the basis of neurophysiological and magnetic resonance imaging assessments, a peripheral irritation of the trigeminal nerve--probably due to entrapment of the motor branches in the infratemporal fossa--is suggested as the cause of the involuntary movement. Local injections of botulinum toxin type A into the masticatory muscles proved to be a successful treatment in both patients.
authors.affiliation: Department of Neurology, Universitätsklinikum Rudolf Virchow, Berlin, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Ebersbach
authors.forename: C
authors.initials: C
authors.lastname: Kabus
authors.forename: L
authors.initials: L
authors.lastname: Schelosky
authors.forename: L
authors.initials: L
authors.lastname: Terstegge
authors.forename: W
authors.initials: W
authors.lastname: Poewe
mesh_terms: D000328:Adult; D001905:Botulinum Toxins / Q000008:administration & dosage; D003389:Cranial Nerve Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D004576:Electromyography / Q000187:drug effects; D005150:Facial Hemiatrophy / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D008279:Magnetic Resonance Imaging; D008297:Male; D008409:Mastication / Q000187:drug effects / Q000502:physiology*; D008410:Masticatory Muscles / Q000187:drug effects / Q000294:innervation*; D009408:Nerve Compression Syndromes / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D013035:Spasm / Q000175:diagnosis / Q000188:drug therapy / Q000503:physiopathology*; D014276:Trigeminal Nerve / Q000187:drug effects / Q000503:physiopathology*
chemical_list: D001905:Botulinum Toxins