Activities of amphotericin B and antifungal azoles alone and in combination against Pseudallescheria boydii.
In order to develop new approaches to treatment of infections due to Pseudallescheria boydii, the in vitro antifungal activity of amphotericin B alone and in combination with miconazole, itraconazole, and fluconazole was studied. Combinations of amphotericin B and antifungal azoles were synergistic, additive, or indifferent in their interaction against P. boydii. Antagonism was not observed.
Walsh
T J
TJ
Infectious Diseases Section, National Cancer Institute, Bethesda, Maryland, USA.
Peter
J
J
McGough
D A
DA
Fothergill
A W
AW
Rinaldi
M G
MG
Pizzo
P A
PA
D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D015725:Fluconazole / Q000494:pharmacology; D017964:Itraconazole / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011541:Pseudallescheria / Q000187:drug effects*
D000935:Antifungal Agents; D001393:Azoles; D017964:Itraconazole; D008825:Miconazole; D000666:Amphotericin B; D015725:Fluconazole