Eye CNG channel is modulated by nicotine.
The cyclic-nucleotide gated channel (CNG channel) of the rod outer segment of the retina (ROS) has its closed conformation stabilized by nicotine. Calcium and cGMP influence the Ki of the channel current to nicotine. Calcium lowers the Ki and cGMP increases it, giving a range of Ki between 10(-11) and 10(-8) M.
McGeoch
J E
JE
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
McGeoch
M W
MW
Guidotti
G
G
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D006152:Cyclic GMP / Q000494:pharmacology; D054815:Cyclic Nucleotide-Gated Cation Channels; D004305:Dose-Response Relationship, Drug; D005136:Eye Proteins / Q000737:chemistry* / Q000187:drug effects / Q000502:physiology*; D015640:Ion Channel Gating / Q000187:drug effects / Q000502:physiology; D007473:Ion Channels / Q000737:chemistry* / Q000187:drug effects / Q000502:physiology*; D007700:Kinetics; D008433:Mathematics; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D008954:Models, Biological; D009538:Nicotine / Q000494:pharmacology*; D011487:Protein Conformation / Q000187:drug effects*; D011817:Rabbits; D012160:Retina / Q000187:drug effects / Q000502:physiology*; D012374:Rod Cell Outer Segment / Q000378:metabolism*
D054815:Cyclic Nucleotide-Gated Cation Channels; D005136:Eye Proteins; D007473:Ion Channels; D009538:Nicotine; D006152:Cyclic GMP; D002118:Calcium