title: Alterations in GABAA receptor binding in the prefrontal cortex following exposure to chronic stress.
abstract: The present study was designed to examine the effects of chronic stress on GABAA receptor binding. Animals were randomly assigned to either a control, acute, or chronic stress condition and changes in specific binding were assessed using the GABAA receptor antagonist [3H]SR 95531. Exposure to chronic restraint stress led to a significant reduction in GABAA receptor binding in the prefrontal cortex. Alterations in specific binding were not observed in the cerebellum, caudate-putamen, hippocampus, or cingulate cortex however, suggesting that the effects of chronic stress may be regionally specific. Exposure to acute restraint did not lead to a significant alteration in [3H]SR 95531 binding in any brain region examined.
authors.affiliation: Department of Psychiatry, New York University, New York 10003, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Gruen
authors.forename: K
authors.initials: K
authors.lastname: Wenberg
authors.forename: R
authors.initials: R
authors.lastname: Elahi
authors.forename: A J
authors.initials: AJ
authors.lastname: Friedhoff
mesh_terms: D000818:Animals; D002908:Chronic Disease; D058787:GABA-A Receptor Antagonists; D008297:Male; D017397:Prefrontal Cortex / Q000378:metabolism*; D011724:Pyridazines / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism*; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*
chemical_list: D058787:GABA-A Receptor Antagonists; D011724:Pyridazines; D011963:Receptors, GABA-A; C049853:gabazine