The influence of some cations on PAF-induced gastric mucosal damage in rats.
We investigated the influences of Li2CO3 1 g/kg i.p., MgSO4 1 g/kg i.p. and Zinc acexamate 100 mg/kg p.o. on gastric lesions induced by Platelet Activating Factor (PAF), 2 micrograms/kg i.v. in rats. Our data show that, Li+ has no a significant influence, while Mg2+ decrease significantly the PAF induced gastric lesions.
Nechifor
M
M
Department of Pharmacology, Univ. Med. Pharm. Iaşi, Romănia.
Neughebauer
B I
BI
Adomnicĭ
M
M
Teslaru
E
E
Filip
C
C
Negru
A
A
D000614:Aminocaproates; D015119:Aminocaproic Acid / Q000494:pharmacology; D000818:Animals; D002412:Cations / Q000494:pharmacology; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D016651:Lithium Carbonate / Q000494:pharmacology*; D008278:Magnesium Sulfate / Q000494:pharmacology*; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000614:Aminocaproates; D002412:Cations; D010972:Platelet Activating Factor; D016651:Lithium Carbonate; D008278:Magnesium Sulfate; C018802:6-acetylaminocaproic acid; D015119:Aminocaproic Acid