title: [A case report of prostate cancer resistant to endocrine therapy successfully treated with intra-arterial chemotherapy].
abstract: A 73-year-old male with low abdominal pain on urination and frequent urination was diagnosed as poorly differentiated adenocarcinoma of prostate. He received endocrine therapy with DESD and bilateral orchiectomy. This treatment was not effective, so he was given intra-arterial infusion chemotherapy with MTX, ADM and CDDP using the reservoir system. After 2 courses of this chemotherapy the regression rate was 75%, and the pathological examination after the chemotherapy revealed no cancer cells. There is no established chemotherapy for prostate cancer at present. Thus this case is very suggestive for the treatment of prostate cancer.
authors.affiliation: Dept. of Urology, Gifu University School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Mima
authors.forename: M
authors.initials: M
authors.lastname: Asano
authors.forename: S
authors.initials: S
authors.lastname: Ozeki
authors.forename: H
authors.initials: H
authors.lastname: Ehara
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Ishihara
authors.forename: T
authors.initials: T
authors.lastname: Deguchi
authors.forename: M
authors.initials: M
authors.lastname: Kuriyama
authors.forename: Y
authors.initials: Y
authors.lastname: Ban
authors.forename: Y
authors.initials: Y
authors.lastname: Kawada
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy*; D000368:Aged; D018931:Antineoplastic Agents, Hormonal; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002945:Cisplatin / Q000008:administration & dosage; D004054:Diethylstilbestrol / Q000031:analogs & derivatives; D004317:Doxorubicin / Q000008:administration & dosage; D004334:Drug Administration Schedule; D019008:Drug Resistance, Neoplasm; D016179:Granulocyte Colony-Stimulating Factor / Q000008:administration & dosage; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage; D011471:Prostatic Neoplasms / Q000188:drug therapy*; D012074:Remission Induction
chemical_list: D018931:Antineoplastic Agents, Hormonal; D016179:Granulocyte Colony-Stimulating Factor; D004054:Diethylstilbestrol; D004317:Doxorubicin; C004955:fosfestrol; D002945:Cisplatin; D008727:Methotrexate