Peripheral T-cell lymphoma in a chronically immunosuppressed renal transplant patient.
Non-Hodgkin large cell lymphomas occurs more commonly in organ-transplanted patients than in the general population. They are usually of B-cell origin whereas T-cell lymphomas are rare. We report a new case of peripheral T-cell lymphoma in an immunosuppressed renal transplanted patient. The patient presented a hepatosplenic mass with a widespread extension causing serious pancytopenia. It was classified as a pleomorphic medium and large cell type and corresponded to the "common" alpha beta-TCR type lymphoma. Lymphomatous cells exhibited an incomplete mature T-cell phenotype. T-cell receptor gene clonal rearrangement associated with a germline configuration of the immunoglobulin heavy chain gene confirmed a clonal T-cell genotype. By using both Southern blot analysis and polymerase chain reaction, we failed to demonstrate any association with Epstein-Barr virus or human T-cell lymphotropic virus type I or type II.
Labouyrie
E
E
Laboratoire d'Anatomie Pathologique, Hôpital Haut-Lévêque, Pessac, France.
Morel
D
D
Boiron
J M
JM
Dubus
P
P
Montastruc
M
M
Bloch
B
B
Reiffers
J
J
de Mascarel
A
A
Merlio
J P
JP
D000328:Adult; D001483:Base Sequence; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects*; D016411:Lymphoma, T-Cell, Peripheral / Q000209:etiology / Q000473:pathology*; D008297:Male; D008969:Molecular Sequence Data