The effect of caffeine on the pharmacokinetics of acetaminophen in man.
The influence of caffeine (60 mg) was studied on the pharmacokinetic characteristics of acetaminophen (500 mg single dose) in ten healthy male human volunteers in a complete cross-over design. A high-performance liquid chromatography (HPLC) method was used to analyse serum drug concentrations. Caffeine caused a highly significant (p < 0.01) increase in AUC and AUMC, a significant (p < 0.05) increase in Cmax, and a significant (p < 0.05) decrease in clearance (C1/F) of acetaminophen. We conclude that caffeine taken in doses commonly available commercially or in a cup of coffee can significantly potentiate the therapeutic potential of acetaminophen in man.
Iqbal
N
N
Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
Ahmad
B
B
Janbaz
K H
KH
Gilani
A U
AU
Niazi
S K
SK
D000082:Acetaminophen / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D003069:Coffee; D018592:Cross-Over Studies; D004338:Drug Combinations; D004357:Drug Synergism; D006207:Half-Life; D006801:Humans; D008297:Male
D018712:Analgesics, Non-Narcotic; D000697:Central Nervous System Stimulants; D003069:Coffee; D004338:Drug Combinations; D000082:Acetaminophen; D002110:Caffeine