title: Activities of amphotericin B and antifungal azoles alone and in combination against Pseudallescheria boydii.
abstract: In order to develop new approaches to treatment of infections due to Pseudallescheria boydii, the in vitro antifungal activity of amphotericin B alone and in combination with miconazole, itraconazole, and fluconazole was studied. Combinations of amphotericin B and antifungal azoles were synergistic, additive, or indifferent in their interaction against P. boydii. Antagonism was not observed.
authors.affiliation: Infectious Diseases Section, National Cancer Institute, Bethesda, Maryland, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Walsh
authors.forename: J
authors.initials: J
authors.lastname: Peter
authors.forename: D A
authors.initials: DA
authors.lastname: McGough
authors.forename: A W
authors.initials: AW
authors.lastname: Fothergill
authors.forename: M G
authors.initials: MG
authors.lastname: Rinaldi
authors.forename: P A
authors.initials: PA
authors.lastname: Pizzo
mesh_terms: D000666:Amphotericin B / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D001393:Azoles / Q000494:pharmacology*; D004359:Drug Therapy, Combination / Q000494:pharmacology*; D015725:Fluconazole / Q000494:pharmacology; D017964:Itraconazole / Q000494:pharmacology; D008825:Miconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D011541:Pseudallescheria / Q000187:drug effects*
chemical_list: D000935:Antifungal Agents; D001393:Azoles; D017964:Itraconazole; D008825:Miconazole; D000666:Amphotericin B; D015725:Fluconazole