Plasma interleukin 8 and polymorphonuclear leukocyte elastase concentrations in patients with septic shock.
We determined the plasma concentrations of interleukin 8 (IL-8), polymorphonuclear leukocyte elastase (PMNE), and endotoxin in patients with septic shock in order to investigate the role of IL-8 and PMNE in the development of septic shock, especially in septic adult respiratory distress syndrome (ARDS). The IL-8 concentration in patients with septic shock was 6.28 +/- 9.00 ng/mL (mean +/- SD, n = 29), which was significantly higher (P < 0.0001) than the concentration in septic patients without shock (0.35 +/- 0.35 ng/mL, n = 40). There was a significant correlation between the IL-8 concentration and the PMNE concentration at the onset of septic shock (r = 0.6916, P < 0.0001). The IL-8 concentration was also significantly correlated with the endotoxin concentration (r = 0.5584, P = 0.0016). There was a significant negative correlation (r = -0.8237, P < 0.0001) between the serum PMNE concentration and the oxygenation index (PaO2/FiO2) at the onset of septic shock. These results indicate that IL-8 and PMNE are produced in large quantities when septic shock occurs, and may play a role in the development of septic ARDS.
Endo
S
S
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Inada
K
K
Ceska
M
M
Takakuwa
T
T
Yamada
Y
Y
Nakae
H
H
Kasai
T
T
Yamashita
H
H
Taki
K
K
Yoshida
M
M
D000328:Adult; D004731:Endotoxins / Q000097:blood; D006801:Humans; D007376:Interleukin-2 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood*; D007700:Kinetics; D019272:Leukocyte Elastase; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D010196:Pancreatic Elastase / Q000097:blood*; D012016:Reference Values; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000209:etiology; D012772:Shock, Septic / Q000097:blood*
D004731:Endotoxins; D007376:Interleukin-2; D016209:Interleukin-8; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; D010100:Oxygen