title: Complement C7 M/N allotyping in infectious diseases.
abstract: The allotypes of the C7 M/N polymorphism are determined by ELISA by comparing the reaction pattern of the allospecific monoclonal antibody WU 4-15 with that of polyclonal anti-C7 IgG. In order to find disease associations of the two alleles C7*M and C7*N we tested 528 hospitalised patients, most of them suffering from infectious diseases. No significant association of either of the two C7 M/N alleles to a particular disease was found, in particular refuting the hypothesis that Lyme borreliosis may be more frequent in homozygous carriers of the hypomorphic allele C7*N.
authors.affiliation: Institute for Hygiene, University of Innsbruck, Austria.
authors.forename: R
authors.initials: R
authors.lastname: Würzner
authors.forename: B M
authors.initials: BM
authors.lastname: Sölder
authors.forename: W M
authors.initials: WM
authors.lastname: Prodinger
authors.forename: M P
authors.initials: MP
authors.lastname: Dierich
mesh_terms: D000483:Alleles; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology*; D003184:Complement C7 / Q000032:analysis* / Q000145:classification; D006801:Humans; D011110:Polymorphism, Genetic; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology*
chemical_list: D003184:Complement C7