Determination of a cardiac antiarrhythmic, tricyclic antipsychotics and antidepressants in human and animal urine by micellar electrokinetic capillary chromatography using a bile salt.
A micellar electrokinetic capillary chromatographic method based on the use of sodium taurodeoxycholate has been developed to detect and quantitate of 26 tricyclic drugs. Detection limits in urine down to 4 ng/ml have been obtained. The method uses a simple liquid-liquid extraction and recovery of analytes followed by ultraviolet detection.
Aumatell
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Australian Government Analytical Laboratory, Pymble, NSW.
Wells
R J
RJ
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000652:urine*; D000929:Antidepressive Agents, Tricyclic / Q000652:urine*; D014150:Antipsychotic Agents / Q000652:urine*; D001647:Bile Acids and Salts; D002417:Cattle; D019075:Electrophoresis, Capillary / Q000379:methods*; D006736:Horses; D006801:Humans; D008297:Male; D013045:Species Specificity; D013056:Spectrophotometry, Ultraviolet; D013501:Surface-Active Agents / Q000737:chemistry; D013552:Swine; D013657:Taurodeoxycholic Acid / Q000737:chemistry
D000889:Anti-Arrhythmia Agents; D000929:Antidepressive Agents, Tricyclic; D014150:Antipsychotic Agents; D001647:Bile Acids and Salts; D013501:Surface-Active Agents; D013657:Taurodeoxycholic Acid