Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance and AIDS.
The cell surface molecule APO-1/Fas(CD95), a member of the Tumor Necrosis Factor (TNF) receptor/Nerve Growth Factor (NGF) receptor superfamily mediates apoptosis upon cross-linking by agonistic antibodies or its ligand. Recent findings suggest that APO-1/Fas(CD95) and its ligand are the key molecules for antigen receptor-induced apoptosis in activated mature T cells. Here we propose a mechanism for antigen receptor-induced apoptosis of activated T cells via APO-1 ligand mediated autocrine suicide. This mechanism may also contribute to the depletion of CD4+ T cells in AIDS.
Dhein
J
J
Tumorimmunology Program, German Cancer Research Center, Heidelberg.
Walczak
H
H
Westendorp
M O
MO
Bäumler
C
C
Stricker
K
K
Frank
R
R
Debatin
K M
KM
Krammer
P H
PH
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D017209:Apoptosis; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D018448:Models, Immunological; D009154:Mutation; D017475:Receptors, Nerve Growth Factor / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D019014:fas Receptor / Q000235:genetics / Q000276:immunology / Q000502:physiology*
D015703:Antigens, CD; D017475:Receptors, Nerve Growth Factor; D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor