title: Role of gastroesophageal reflux disease in patients with cervical symptoms.
abstract: Otolaryngologists commonly see patients with various nonspecific upper aerodigestive or "cervical" symptoms. The relationship between gastroesophageal reflux disease and these symptoms has been studied but remains unclear. We reviewed the records of 216 patients with various cervical symptoms. Each patient underwent a uniform investigation that included barium swallow, esophageal manometry, acid stimulation testing, and esophagoscopy with distal biopsy. Patients were treated with a combination of a histamine H2 blocker or omeprazole and a prokinetic agent. Follow-up was obtained in 194 patients. Overall, evidence of gastroesophageal reflux disease was detected in 73% of patients. Complete resolution or improvement of symptoms was seen in 84% of patients with treatment. We believe gastroesophageal reflux disease is an important factor in the cause of cervical problems.
authors.affiliation: Department of Otolaryngology, Mount Sinai Hospital, University of Toronto, Ontario, Canada.
authors.forename: R
authors.initials: R
authors.lastname: Rival
authors.forename: R
authors.initials: R
authors.lastname: Wong
authors.forename: M
authors.initials: M
authors.lastname: Mendelsohn
authors.forename: S
authors.initials: S
authors.lastname: Rosgen
authors.forename: M
authors.initials: M
authors.lastname: Goldberg
authors.forename: J
authors.initials: J
authors.lastname: Freeman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000897:Anti-Ulcer Agents / Q000627:therapeutic use; D001466:Barium Sulfate; D001706:Biopsy; D002933:Cineradiography; D003680:Deglutition Disorders / Q000209:etiology*; D003937:Diagnosis, Differential; D004945:Esophagoscopy; D005260:Female; D005471:Fluoroscopy; D005500:Follow-Up Studies; D005764:Gastroesophageal Reflux / Q000150:complications* / Q000175:diagnosis / Q000000981:diagnostic imaging / Q000503:physiopathology; D006635:Histamine H2 Antagonists / Q000627:therapeutic use; D006801:Humans; D006851:Hydrochloric Acid; D008297:Male; D008365:Manometry; D008787:Metoclopramide / Q000627:therapeutic use; D008875:Middle Aged; D009853:Omeprazole / Q000627:therapeutic use; D010528:Peristalsis / Q000187:drug effects; D010608:Pharyngeal Diseases / Q000209:etiology*; D010612:Pharyngitis / Q000209:etiology*; D010865:Pilot Projects; D011899:Ranitidine / Q000627:therapeutic use
chemical_list: D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D001466:Barium Sulfate; D011899:Ranitidine; D009853:Omeprazole; D008787:Metoclopramide; D006851:Hydrochloric Acid