[Distribution of androgen receptor in primary liver cancer and its clinical significance].
A method of receptor binding assay (RBA) was adopted to measure the distribution of androgen receptor (AR) in liver cancer and tissue in its vicinity in 63 patients with primary liver cancer undergone laparotomy and in non-tumor liver tissue in 7 cases with gastric carcinoma. The results showed (1) AR was demonstrated in the liver cancer tissue and surrounding non-tumorous tissue, and the non-tumor liver tissue. The content of AR in the nucleus was significantly higher than that in the cytoplasm. (2) There was no difference in the amount of AR between the tumor tissue and tissue surrounding it. The expression of AR in the liver cancer tissue or the surrounding tissue was more marked than that in the non-tumor tissue. (3) Expression of AR in the tumor tissue seemed to correlate with more frequent tumor recurrence one year after radical resection.
Cui
S
S
Tumor Hospital of Guang Zhou.
Li
G
G
D000328:Adult; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000737:chemistry* / Q000601:surgery; D005260:Female; D006498:Hepatectomy; D006801:Humans; D008099:Liver / Q000737:chemistry; D008113:Liver Neoplasms / Q000737:chemistry* / Q000601:surgery; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D011944:Receptors, Androgen / Q000032:analysis*
D011944:Receptors, Androgen