Apical segmental dysfunction in hypertrophic cardiomyopathy: progression into end-stage heart failure with sudden cardiac death.
Apical segmental dysfunction is an unusual finding in hypertrophic cardiomyopathy (HCM). It is characterized by a poor clinical course and a high incidence of malignant ventricular tachyarrhythmias. Long-term prognosis of patients with HCM and apical segmental dysfunction is still unclear. We report 2 cases of apical segmental dysfunction in HCM in whom progressive apical dilatation and congestive heart failure developed. Both patients died suddenly, and intractable ventricular tachyarrhythmias were documented in 1 case during resuscitation. This report provides further evidence that apical segmental dysfunction might predict a subgroup of patients with HCM who are likely to develop end-stage heart failure and are at high risk of sudden cardiac death.
Ko
Y L
YL
Department of Internal Medicine, National Taiwan University Hospital, Taipei, Republic of China.
Lin
J L
JL
Lei
M H
MH
Chen
J J
JJ
Tsou
S S
SS
Kuan
P
P
Lien
W P
WP
D000293:Adolescent; D000328:Adult; D002312:Cardiomyopathy, Hypertrophic / Q000150:complications* / Q000175:diagnosis; D016757:Death, Sudden, Cardiac / Q000209:etiology*; D006333:Heart Failure / Q000175:diagnosis / Q000209:etiology*; D006801:Humans; D008297:Male; D018487:Ventricular Dysfunction, Left / Q000150:complications* / Q000175:diagnosis