Prevention of metastasis from mouse mammary carcinomas with liposomes carrying doxorubicin.
Weekly treatments with doxorubicin encapsulated in long circulating, sterically stabilised liposomes (DOX-SL) reduced the incidence of metastases from primary mammary carcinoma from 24 of 47 untreated mice to 3 of 23 treated mice. Toxic side-effects were limited to minor, transient weight losses.
Vaage
J
J
Department of Molecular Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263, USA.
Donovan
D
D
Loftus
T
T
Working
P
P
D000818:Animals; D004317:Doxorubicin / Q000008:administration & dosage* / Q000627:therapeutic use; D004337:Drug Carriers; D005260:Female; D008081:Liposomes; D008175:Lung Neoplasms / Q000517:prevention & control / Q000556:secondary; D008325:Mammary Neoplasms, Experimental / Q000188:drug therapy* / Q000473:pathology; D051379:Mice; D008809:Mice, Inbred C3H; D009362:Neoplasm Metastasis / Q000517:prevention & control*
D004337:Drug Carriers; D008081:Liposomes; D004317:Doxorubicin