title: Human corneal oxygen demands at superior, central, and inferior sites.
abstract: BACKGROUND
  Oxygen depletion of the superior and central cornea in response to standard conditions is of clinical interest because of pathological conditions, usually resulting from the hypoxia of contact lens wear, that affect these areas. A study was designed to determine if there are differences in oxygen depletion at these two sites.
  
  
  METHODS
  Oxygen depletion times from a standard reservoir following corneal exposure to three different oxygenated environments (20.9%, 5%, and 0% oxygen) were assessed micropolarographically at central, superior, and inferior corneal surface positions on both corneas of six healthy young adult human subjects.
  
  
  RESULTS
  Based on 48 measurements for each corneal position at each oxygen percentage (432 total measurements), the superior cornea 1.0 mm from the limbus was found to have longer oxygen depletion times (slower oxygen uptake rates) than the central or inferior corneal locations. The differences reduced to nearly zero during the course of the initial 1.5-day testing procedure, but were re-established months later when testing was resumed.
  
  
  CONCLUSIONS
  There is a small reversible increase in superior corneal oxygen depletion time (a decrease of the oxygen uptake rate) due to the chronic hypoxia that results from the presence of an overlying superior eyelid or other physiological factors.
authors.affiliation: School of Optometry, University of Alabama at Birmingham 35294-0010, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Benjamin
authors.forename: C M
authors.initials: CM
authors.lastname: Ruben
mesh_terms: D000328:Adult; D003315:Cornea / Q000033:anatomy & histology / Q000502:physiology*; D006801:Humans; D008839:Microelectrodes; D010100:Oxygen / Q000378:metabolism; D010101:Oxygen Consumption / Q000502:physiology*; D011048:Polarography
chemical_list: D010100:Oxygen