title: Arguments against routine contralateral mastectomy or undirected biopsy for invasive lobular breast cancer.
abstract: BACKGROUND
  Management of the contralateral normal-appearing breast in a patient with ipsilateral invasive lobular carcinoma (ILC) is controversial.
  
  
  METHODS
  The case histories of patients with histologically proven ILC who underwent definitive surgery at our institution from 1978 to 1991 were retrospectively reviewed.
  
  
  RESULTS
  Of the 419 women with ILC, 36 (8.6%) had bilateral cancer, with a cumulative risk of 10% at 10 years. Twenty-five (69%) of these cancers were suspected before operation. From 105 contralateral prophylactic surgical procedures, seven (64%) in-situ and four (36%) invasive cancers were detected. The age at presentation and multifocality of the index cancer were significantly different between patients with unilateral and those with bilateral cancers. No survival difference was noted between patients whose contralateral cancers were suspected clinically and those whose cancers were detected prophylactically. Survival rates between patients with unilateral versus bilateral cancers were also not different. However, patients with contralateral prophylactic surgery had a better prognosis than those with unilateral tumors and no prophylaxis.
  
  
  CONCLUSIONS
  Ten percent of patients with ILC experienced bilateral cancers during a period of 10 years. Survival was not influenced by the development of a second cancer, but it improved with surgical prophylaxis.
authors.affiliation: Department of General Surgery, Mayo Clinic, Rochester, Minn. 55905, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Lee
authors.forename: C S
authors.initials: CS
authors.lastname: Grant
authors.forename: J H
authors.initials: JH
authors.lastname: Donohue
authors.forename: T B
authors.initials: TB
authors.lastname: Crotty
authors.forename: W S
authors.initials: WS
authors.lastname: Harmsen
authors.forename: D M
authors.initials: DM
authors.lastname: Ilstrup
mesh_terms: D000328:Adult; D001706:Biopsy; D001943:Breast Neoplasms / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control / Q000601:surgery*; D018275:Carcinoma, Lobular / Q000453:epidemiology / Q000473:pathology* / Q000517:prevention & control / Q000601:surgery*; D005260:Female; D006801:Humans; D015993:Life Tables; D008408:Mastectomy; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009367:Neoplasm Staging; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000453:epidemiology* / Q000473:pathology / Q000601:surgery; D016609:Neoplasms, Second Primary / Q000453:epidemiology / Q000517:prevention & control*; D011379:Prognosis; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012306:Risk; D015996:Survival Rate