title: In vitro LAK (lymphokine activated killer) activity following autologous peripheral blood stem cell is significantly greater than that following autologous bone marrow and allogeneic bone marrow transplantation.
abstract: LAK activity is known to increase following autologous and allogeneic bone marrow transplant and peripheral blood stem cell transplant (PBSCT). The aim of this study was to directly compare the 3 types of transplant and the LAK activity generated. LAK activity following PBSCT is significantly greater than that following autologous bone marrow transplantation and even allogeneic transplantation up to 8 weeks. The type of killer cells generated is similar for the different types of transplants, with most killing activity following PBSCT due to CD56+ cells, though CD3+ cells also contribute. This study would suggest that attempts to augment the graft-versus-leukaemia effect is more likely to be successful following PBSCT than autologous bone marrow transplantation.
authors.affiliation: Department of Haematology, University of Wales College of Medicine, Heath Park, Cardiff, UK.
authors.forename: C
authors.initials: C
authors.lastname: Fegan
authors.forename: H
authors.initials: H
authors.lastname: Thomas
authors.forename: R
authors.initials: R
authors.lastname: Bailey-Wood
authors.forename: S
authors.initials: S
authors.lastname: Coleman
authors.forename: S
authors.initials: S
authors.lastname: Phillips
authors.forename: T
authors.initials: T
authors.lastname: Hoy
authors.forename: J A
authors.initials: JA
authors.lastname: Whittaker
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016026:Bone Marrow Transplantation; D017252:CD3 Complex / Q000032:analysis; D019002:CD56 Antigen / Q000032:analysis; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans; D016130:Immunophenotyping; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology*; D008875:Middle Aged; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D017252:CD3 Complex; D019002:CD56 Antigen