title: Destructive lymphadenopathy and T-lymphocyte activation in adult-onset Still's disease.
abstract: Recurrent arthritis, fever and lymphadenopathy are symptoms of adult onset of Still's disease (AOSD). Differential diagnosis requires the exclusion of infections or malignant lymphomas. We report on a case of AOSD showing destructive lymphadenopathy, immunophenotyping of peripheral blood leucocytes revealed strong activation of T-lymphocytes. Bone marrow biopsy also showed an increase of lymphopoietic cells to 23%. Analysis of peripheral blood lymphocytes (PBL) after remission showed no remaining signs of activation. Analysis of lymphocyte activation by flow cytometry correlated with disease activity.
authors.affiliation: Department of Internal Medicine III, University of Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Koeller
authors.forename: H
authors.initials: H
authors.lastname: Kiener
authors.forename: I
authors.initials: I
authors.lastname: Simonitsch
authors.forename: M
authors.initials: M
authors.lastname: Aringer
authors.forename: C W
authors.initials: CW
authors.lastname: Steiner
authors.forename: K
authors.initials: K
authors.lastname: Machold
authors.forename: W
authors.initials: W
authors.lastname: Graninger
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000209:etiology / Q000473:pathology*; D008213:Lymphocyte Activation; D016706:Still's Disease, Adult-Onset / Q000150:complications*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*