title: Diagnosis and prognosis of AIDS-related cholangitis.
abstract: OBJECTIVE
  To determine more precisely the clinical and biological characteristics of AIDS-related cholangitis, and to investigate prognostic variables of this disease.
  
  
  METHODS
  Retrospective clinical and prognostic study.
  
  
  METHODS
  Biliary unit, Bicêtre Hospital, France.
  
  
  METHODS
  HIV-positive patients (n = 52) referred to the unit between December 1986 and June 1993 for biliary symptoms leading to the suspicion of AIDS-related cholangitis, (42 men; 10 women; mean age, 37 +/- 8 years).
  
  
  METHODS
  Endoscopic retrograde cholangiopancreatography (ERCP) was performed in order to determine the cause of the biliary symptoms.
  
  
  METHODS
  Clinical features and evolution of the cholangitis.
  
  
  RESULTS
  Among the 52 patients, 45 met the ERCP criteria of AIDS-related cholangitis (36 men; nine women). The diagnosis of cholangitis was strongly suggested by abdominal ultrasonography in 47% of the cases. ERCP showed papillary stenosis, diffuse cholangitis, extrahepatic cholangitis alone, and intrahepatic cholangitis alone in 60, 67, 7 and 27%, respectively. Endoscopic sphincterotomy was performed in 28 patients. Pain was relieved by sphincterotomy in nine patients, but the other clinical or biological features were not influenced. One-year and 2-year survival rates were 41 +/- 7% and 8 +/- 4%, respectively. Multidimensional analysis using a Cox model showed that a lymphocyte count > 500 x 10(6)/l was the only independent predictive factor of better survival.
  
  
  CONCLUSIONS
  AIDS-related cholangitis is a disease which leads preferentially to papillary stenosis or diffuse abnormalities of the biliary tract. Prognostic factors depend on the stage of the HIV infection. Another diagnosis of cholestasis was found in approximately 15% of the patients who showed biliary symptoms.
authors.affiliation: Department of Hepato-Gastroenterology, Bicêtre Hospital, Le Kremlin Bicêtre, France.
authors.forename: M
authors.initials: M
authors.lastname: Ducreux
authors.forename: C
authors.initials: C
authors.lastname: Buffet
authors.forename: P
authors.initials: P
authors.lastname: Lamy
authors.forename: L
authors.initials: L
authors.lastname: Beaugerie
authors.forename: J
authors.initials: J
authors.lastname: Fritsch
authors.forename: A
authors.initials: A
authors.lastname: Choury
authors.forename: C
authors.initials: C
authors.lastname: Liguory
authors.forename: P
authors.initials: P
authors.lastname: Longuet
authors.forename: J P
authors.initials: JP
authors.lastname: Gendre
authors.forename: F
authors.initials: F
authors.lastname: Vachon
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D000469:Alkaline Phosphatase / Q000097:blood; D001663:Bilirubin / Q000097:blood; D002760:Cholangiopancreatography, Endoscopic Retrograde; D002761:Cholangitis / Q000150:complications* / Q000175:diagnosis* / Q000601:surgery; D005260:Female; D006801:Humans; D018655:Lymphocyte Count; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies; D016717:Sphincterotomy, Endoscopic
chemical_list: D000410:Alanine Transaminase; D000469:Alkaline Phosphatase; D001663:Bilirubin