title: [Successful treatment of agranulocytosis caused by carbimazole using recombinant granulocyte-macrophage colony stimulating factor].
abstract: The authors describe a patient with hyperthyroidism who developed after three weeks' treatment with carbimazole agranulocytosis and the condition was complicated by septic shock. The authors used for treatment in addition to antibiotics and corticoids, for the first time in their practice, human recombinant granulocyte macrophage colonies stimulating factor (rHuGM-CSF) which produced a very favourable effect. In the meantime the patient was prepared for goitrectomy, operated and discharged in a satisfactory condition to have ambulatory treatment.
authors.affiliation: Interná klinika A Nemocnice F. D. Roosevelta, Banská Bystrica.
authors.forename: A
authors.initials: A
authors.lastname: Kreze
authors.forename: A
authors.initials: A
authors.lastname: Kuviková
authors.forename: L
authors.initials: L
authors.lastname: Laca
authors.forename: S
authors.initials: S
authors.lastname: Kompis
authors.forename: M
authors.initials: M
authors.lastname: Dobáková
authors.forename: P
authors.initials: P
authors.lastname: Babusík
authors.forename: L
authors.initials: L
authors.lastname: Matecek
authors.forename: E
authors.initials: E
authors.lastname: Pekárová
mesh_terms: D000380:Agranulocytosis / Q000139:chemically induced* / Q000628:therapy*; D002231:Carbimazole / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000627:therapeutic use*; D006111:Graves Disease / Q000188:drug therapy; D006801:Humans; D008875:Middle Aged; D011994:Recombinant Proteins
chemical_list: D011994:Recombinant Proteins; D016178:Granulocyte-Macrophage Colony-Stimulating Factor; D002231:Carbimazole
vernacular_title: Uspesná liecba agranulocytózy vyvolanej karbimazolom pomocou rekombinantného granulocyty-makrofágy kolónie stimulujúceho faktora.