The sequence of a Xenopus laevis TFIID subunit reveals remarkable conservation among vertebrates.
A cDNA clone encoding a Xenopus laevis (Xl) homologue of human transcription factor IID (TFIID) subunit p80 was isolated and sequenced. The deduced 618-amino-acid (aa) sequence was compared to the homologous from human, mouse, rat and Drosophila melanogaster (Dm). A highly conserved region exists in the central region among these species. In contrast, the C-terminal region has significant homology among vertebrates, whereas the corresponding region of the Dm homologue shows poor homology.
Hasegawa
S
S
Department of Cellular Biology, University of Tokyo, Japan.
Kuzuhara
T
T
Horikoshi
M
M
D000595:Amino Acid Sequence; D000818:Animals; D017124:Conserved Sequence; D004331:Drosophila melanogaster; D006801:Humans; D046911:Macromolecular Substances; D051379:Mice; D008969:Molecular Sequence Data; D051381:Rats; D017386:Sequence Homology, Amino Acid; D035362:Transcription Factor TFIID; D014157:Transcription Factors / Q000737:chemistry / Q000235:genetics*; D014714:Vertebrates / Q000235:genetics*; D014982:Xenopus laevis / Q000235:genetics*
D046911:Macromolecular Substances; D035362:Transcription Factor TFIID; D014157:Transcription Factors