Intravenous injection of rabbit apolipoprotein A-I inhibits the progression of atherosclerosis in cholesterol-fed rabbits.
The effects of intravenous injection of purified rabbit apoA-I on the progression of aortic atherosclerosis in cholesterol-fed rabbits were examined. In experiment 1, 28 rabbits were equally divided into groups A and B and fed a 0.5% cholesterol diet for 90 days. For the last 30 days, group B received 40 mg apoA-I every week. The fatty streak lesions in group B (23.9 +/- 15.6%) were significantly suppressed compared with those in group A (46.0 +/- 24.9%) (P < .05). In experiment 2, 33 rabbits were divided into four groups (8 or 9 rabbits per group) and fed a 0.5% cholesterol diet. Group A was killed on day 105, while groups B, C, and D were maintained for an additional 60 days on a normal diet, during which time groups C and D received 1 mg apoA-I every other day or 40 mg apoA-I every week, respectively. The lesions in group C (70.2 +/- 15.4%) and group D (65.7 +/- 20.0%) were significantly suppressed compared with those in group B (86.2 +/- 13.7%) (P < .05) but were not reduced to the level of group A (50.0 +/- 22.9%). Although apparent regression was not observed under these conditions, the present study provided the first evidence for the antiatherogenic effect of homologous and apoA-I on the progression of atherosclerosis in cholesterol-fed rabbits.
Miyazaki
A
A
Department of Biochemistry, Kumamoto University School of Medicine, Japan.
Sakuma
S
S
Morikawa
W
W
Takiue
T
T
Miake
F
F
Terano
T
T
Sakai
M
M
Hakamata
H
H
Sakamoto
Y
Y
Natio
M
M
D000818:Animals; D016632:Apolipoprotein A-I / Q000494:pharmacology*; D001161:Arteriosclerosis / Q000209:etiology / Q000517:prevention & control*; D002478:Cells, Cultured; D002784:Cholesterol / Q000378:metabolism; D004036:Diet, Atherogenic; D005487:Foam Cells / Q000378:metabolism; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D051379:Mice; D011817:Rabbits
D016632:Apolipoprotein A-I; D002784:Cholesterol