Influence of coronary artery bypass grafting on ventricular late potentials as a predictive factor for ventricular arrhythmias during short- and long-term follow-up.
Ventricular late potentials have been identified as a prognostic factor in the prediction of ventricular arrhythmias in patients after myocardial infarction. In this prospective study the possible impact of late potentials on the prediction of ventricular arrhythmias in the short- and long-term follow-up after coronary artery bypass grafting was evaluated. In 188 patients (165 men, 23 women, age 57 +/- 8 years) with chronic coronary heart disease 48 (26%) had late potentials before bypass grafting; after the procedure this was reduced to 39 (21%) (ns). In 16 (33%) of the 48 patients with late potentials before bypass grafting, late potentials were no longer present in the short-term follow-up (9 +/- 6 days). Conversely, seven (5%) of the 140 patients without late potentials before bypass grafting had late potentials in the short-term follow-up after grafting. Nine (19%) of the 48 patients with late potentials before bypass grafting had ventricular arrhythmias in the peri-operative phase, which had to be treated with antiarrhythmic agents. In contrast, only three (2%) of the 140 patients without late potentials before bypass grafting had to be treated for ventricular arrhythmias (P < 0.001). In the long-term follow-up of 29 +/- 3 months, there were no events in the group of 149 patients without late potentials after grafting. In the 39 patients with late potentials after grafting, there were two (5%) events (two patients with arrhythmic syncope).


CONCLUSIONS
(1) Patients with late potentials before bypass grafting have a markedly higher risk of developing serious ventricular arrhythmias in the peri-operative period than patients without late potentials. (2) Patients without late potentials have a very low risk of developing serious ventricular arrhythmias in the peri-operative period. (3) During long-term follow-up there was only a low probability of developing symptomatic ventricular arrhythmias in patients with or without late potentials.
Frielingsdorf
J
J
Cardiology and Cardiovascular Surgery Division, Triemli Hospital Zürich, Switzerland.
Gerber
A E
AE
Laske
A
A
Bertel
O
O
D001145:Arrhythmias, Cardiac / Q000175:diagnosis* / Q000209:etiology; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000150:complications / Q000401:mortality / Q000601:surgery*; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis*; D011446:Prospective Studies; D012307:Risk Factors; D018754:Ventricular Dysfunction / Q000175:diagnosis* / Q000209:etiology