Polymorphic forms of the Ah receptor and induction of the CYP1A1 gene.
Induction of cytochrome P4501A1 (CYP1A1) by certain xenobiotics is mediated by the Ah receptor/Arnt complex. The present knowledge about the molecular process of induction is summarized with special attention to our recent work on characterization of the polymorphic forms of the Ah receptor.
Fujii-Kuriyama
Y
Y
Department of Chemistry, Faculty of Science, Tohoku University, Sendai, Japan.
Ema
M
M
Mimura
J
J
Matsushita
N
N
Sogawa
K
K
D003001:Cloning, Molecular; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis* / Q000235:genetics*; D004790:Enzyme Induction / Q000187:drug effects; D006801:Humans; D016297:Mutagenesis, Site-Directed; D011110:Polymorphism, Genetic; D018336:Receptors, Aryl Hydrocarbon / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D015262:Xenobiotics / Q000378:metabolism / Q000494:pharmacology*
D018336:Receptors, Aryl Hydrocarbon; D011994:Recombinant Proteins; D015262:Xenobiotics; D003577:Cytochrome P-450 Enzyme System