[Effects of influenza virus proteins on immunocompetent cells of the host].
Only 2 influenza viral proteins--HA and M--have been shown to be active against host T cells, M protein being more active than HA in some tests when interacted with CD4 receptor. M protein stimulated the expression of CD25 receptors and the proliferation of lymphocytes; the activated production of alpha-tumor necrosis factor was undetectable when exposed to virus proteins.
Zhilinskaia
I N
IN
Kalinina
N M
NM
Poliakova
E P
EP
Puchkova
G F
GF
D015704:CD4 Antigens / Q000276:immunology; D003601:Cytotoxicity Tests, Immunologic; D006389:Hemagglutinins, Viral / Q000378:metabolism*; D006801:Humans; D009980:Influenza A virus; D007251:Influenza, Human / Q000821:virology*; D008213:Lymphocyte Activation; D008565:Membrane Proteins / Q000378:metabolism*; D009698:Nucleoproteins / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*; D014764:Viral Proteins / Q000378:metabolism*
D015704:CD4 Antigens; D006389:Hemagglutinins, Viral; D008565:Membrane Proteins; D009698:Nucleoproteins; D014764:Viral Proteins
Vozdeĭstvie belkov virusa grippa na immunokompetentnye kletki organizma khoziaina.