The role of nonsteroidal anti-inflammatory drugs in colorectal cancer prevention.
Colorectal cancer is the second leading cause of cancer death in the U.S.A. Recent research suggests that nonsteroidal anti-inflammatory drugs (NSAIDs) are effective in the prevention of colorectal neoplasia. This review summarises the results of research in animals and humans of these compounds in preventing tumours of the colorectum.
Giardiello
F M
FM
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Offerhaus
G J
GJ
DuBois
R N
RN
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D016718:Arachidonic Acid / Q000378:metabolism; D016022:Case-Control Studies; D002986:Clinical Trials as Topic; D015179:Colorectal Neoplasms / Q000517:prevention & control*; D006801:Humans; D051379:Mice; D011446:Prospective Studies; D051381:Rats
D000894:Anti-Inflammatory Agents, Non-Steroidal; D016718:Arachidonic Acid