title: Acute hemolysis during cyclosporine therapy successfully treated with vitamin E.
abstract: The immunosuppressant cyclosporine induces acute hemolysis (hemolytic uremic syndrome) in some patients after transplantation, possibly because of its effects on the vascular endothelium. We report a case of Coombs-negative, non-immune severe hemolytic anemia during cyclosporine therapy after allogeneic bone marrow transplantation for severe aplastic anemia. Uremia was not observed. Vitamin E was effective in treating the intravascular hemolysis.
authors.affiliation: Department of Pediatrics and Clinical Immunology, Mie University School of Medicine, Japan.
authors.forename: E
authors.initials: E
authors.lastname: Azuma
authors.forename: M
authors.initials: M
authors.lastname: Hirayama
authors.forename: T
authors.initials: T
authors.lastname: Nakano
authors.forename: M
authors.initials: M
authors.lastname: Nagai
authors.forename: S
authors.initials: S
authors.lastname: Hiratake
authors.forename: Y
authors.initials: Y
authors.lastname: Komada
authors.forename: M
authors.initials: M
authors.lastname: Sakurai
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000741:Anemia, Aplastic / Q000628:therapy*; D000743:Anemia, Hemolytic / Q000188:drug therapy* / Q000209:etiology; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D016572:Cyclosporine / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D014810:Vitamin E / Q000627:therapeutic use*
chemical_list: D007166:Immunosuppressive Agents; D014810:Vitamin E; D016572:Cyclosporine