title: Local massage after vaccination enhances the immunogenicity of diphtheria-tetanus-pertussis vaccine.
abstract: The effect of local massage on adverse reactions and immunogenicity of diphtheria-tetanus-pertussis vaccine was investigated. After diphtheria-tetanus-pertussis vaccination 327 infants were either massaged or not, and adverse reactions were evaluated. Local pain and fever were more frequent in the massage group. The extra febrile episodes from massage were mild (38-39 degrees C). For evaluation of the antibody responses, 124 infants were recruited into massage or nonmassage cohorts and antibody production was measured at 2, 6, 7, 18 and 19 months of age, respectively. Subjects in the massage group developed significantly higher antibodies against filamentous hemagglutinin at 6 and 7 months of age, pertussis toxin at 6, 7, 18 and 19 months of age, pertussis agglutinogen at 18 and 19 months of age and those in the nonmassage group. Local massage after diphtheria-tetanus-pertussis vaccination was associated with better immunogenicity and more adverse reactions, including low grade fever and local pain, which were mild and not particularly disturbing.
authors.affiliation: Department of Pediatrics, Taipei Municipal Maternal and Child Health Hospital, Taiwan.
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsu
authors.forename: L M
authors.initials: LM
authors.lastname: Huang
authors.forename: C Y
authors.initials: CY
authors.lastname: Lee
authors.forename: T Y
authors.initials: TY
authors.lastname: Lin
authors.forename: P I
authors.initials: PI
authors.lastname: Lee
authors.forename: J M
authors.initials: JM
authors.lastname: Chen
mesh_terms: D000907:Antibodies, Bacterial / Q000096:biosynthesis; D004165:Diphtheria / Q000276:immunology / Q000517:prevention & control; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000008:administration & dosage* / Q000009:adverse effects / Q000276:immunology; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008405:Massage; D013742:Tetanus / Q000276:immunology / Q000517:prevention & control; D014611:Vaccination / Q000009:adverse effects / Q000379:methods*; D014917:Whooping Cough / Q000276:immunology / Q000517:prevention & control
chemical_list: D000907:Antibodies, Bacterial; D015721:Diphtheria-Tetanus-Pertussis Vaccine