title: Prenatal diagnosis and management of fetal goiter caused by maternal Grave's disease.
abstract: We present a case of maternal Grave's disease associated with fetal goitrous hyperthyroidism. Fetal goiter was diagnosed by ultrasound and diagnosis of fetal hyperthyroidism was established by umbilical blood sampling. Fetus was successfully treated by increasing maternal propylthiouracil dosage. Fetal thyroid status was normal at birth. Role of sonography and umbilical blood sampling in management of fetal goiter complicated with maternal Grave's disease is discussed.
authors.affiliation: Department of Obstetrics and Gynecology, East Carolina University School of Medicine, Greenville, NC 27858, USA.
authors.forename: H A
authors.initials: HA
authors.lastname: Hadi
authors.forename: D
authors.initials: D
authors.lastname: Strickland
mesh_terms: D000328:Adult; D013956:Antithyroid Agents / Q000627:therapeutic use; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis* / Q000188:drug therapy; D006042:Goiter / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000188:drug therapy; D006111:Graves Disease / Q000150:complications*; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D011296:Prenatal Diagnosis; D011441:Propylthiouracil / Q000627:therapeutic use; D014463:Ultrasonography
chemical_list: D013956:Antithyroid Agents; D011441:Propylthiouracil