Calcium channel blockade (isradipine) in treatment of hypertension in pregnancy: a randomized placebo-controlled study.
OBJECTIVE
Our purpose was to study the effects of isradipine, a dihydropyridine calcium channel blocker, on mother and fetus in the treatment of hypertensive disorders of pregnancy.


METHODS
The investigation was performed as a two-group, parallel, double-blind multicenter study of isradipine versus placebo. Fifty-four women were randomized to treatment with isradipine slow-release capsules given orally 5 mg twice a day and 57 to a placebo group.


RESULTS
Isradipine lowered the maternal mean arterial blood pressure effectively in women with nonproteinuric hypertension but did not do so in women with proteinuria at recruitment or appearing during treatment. Blood flow in the umbilical artery and maternal renal and liver function were not influenced by treatment. Isradipine had few side effects and was well tolerated.


CONCLUSIONS
Calcium channel blockade with isradipine is effective for treatment of nonproteinuric hypertension but not in preeclampsia.
Wide-Swensson
D H
DH
Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden.
Ingemarsson
I
I
Lunell
N O
NO
Forman
A
A
Skajaa
K
K
Lindberg
B
B
Lindeberg
S
S
Marsàl
K
K
Andersson
K E
KE
D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007231:Infant, Newborn; D017275:Isradipine / Q000627:therapeutic use*; D010919:Placebos; D011225:Pre-Eclampsia / Q000188:drug therapy; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011507:Proteinuria / Q000150:complications
D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D010919:Placebos; D017275:Isradipine