title: Necrotizing fasciitis originating from pinna perichondritis.
abstract: NF is a potentially lethal infectious process usually found in the abdomen, perineum, or extremities. In the head and neck it usually starts from a dental infection but can be initiated from any source. One of the more serious sequelae is extension of the infection down the deep fascial planes of the neck leading to mediastinitis; this is associated with a higher mortality rate. The presence of an associated immunocompromising disease, such as diabetes, has been said to predispose an individual to NF, and the mortality rate has been shown to be higher (although perhaps not significantly so). When first described, NF was thought to be caused only by beta-hemolytic Staphylococcus. Now it known to be a polymicrobial infection with anaerobes and facultative anaerobes found most frequently. Treatment involves broad-spectrum intravenous antibiotics as soon as possible, narrowing the coverage as the results of the gram stain and cultures become available. The importance of aggressive, prompt surgical management cannot be overemphasized in the treatment of NF. Once the diagnosis of NF is strongly suspected, debridement of the affected areas must be accomplished as soon as possible. Despite the advances in the recognition and treatment of NF, there is still significant morbidity and mortality associated with this disease. Continued vigilance must be practiced if the survival rate is to continue to increase.
authors.affiliation: Department of Otolaryngology, New York University School of Medicine, NY 10016, USA.
authors.forename: J
authors.initials: J
authors.lastname: Skorina
authors.forename: D
authors.initials: D
authors.lastname: Kaufman
mesh_terms: D000368:Aged; D000900:Anti-Bacterial Agents; D002356:Cartilage / Q000382:microbiology; D003238:Connective Tissue / Q000382:microbiology; D004359:Drug Therapy, Combination / Q000008:administration & dosage / Q000627:therapeutic use; D004427:Ear Diseases / Q000382:microbiology; D004431:Ear, External / Q000382:microbiology*; D019115:Fasciitis, Necrotizing / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male; D009333:Neck / Q000382:microbiology*; D013203:Staphylococcal Infections / Q000188:drug therapy; D013290:Streptococcal Infections / Q000188:drug therapy
chemical_list: D000900:Anti-Bacterial Agents