T cell proliferation restricted by HLA class II molecules in patients with hen's egg allergy.
We investigated the synergistic effect of anti-HLA class II monoclonal antibodies on proliferative responses to ovalbumin (OA) of T cell line (TCL) cells from five hen's-egg-sensitive patients. Among the five patients, the proliferation of the TCL cells from two patients with AD who have a low immune reaction was restored by the anti-HLA-DQ monoclonal antibodies, and the proliferation of the TCL cells from the other three patients was inhibited by the anti-HLA-DP monoclonal antibodies. These results suggest that a component of the T cell repertoire reactive with OA in hen's-egg-sensitive patients may be restricted by HLA-DP molecules. Furthermore, in hen's-egg-sensitive patients with AD who have a low immune reaction, low responsiveness may be regulated by HLA-DQ molecules.
Shinbara
M
M
Department of Pediatrics, Gifu University School of Medicine, Japan.
Kondo
N
N
Agata
H
H
Fukutomi
O
O
Nishida
T
T
Kobayashi
Y
Y
Orii
T
T
D000818:Animals; D000911:Antibodies, Monoclonal / Q000494:pharmacology; D002460:Cell Line; D002645:Chickens; D002648:Child; D002675:Child, Preschool; D003876:Dermatitis, Atopic / Q000276:immunology*; D004306:Dose-Response Relationship, Immunologic; D004529:Egg White / Q000009:adverse effects; D000939:Epitopes; D005260:Female; D006681:HLA-D Antigens / Q000235:genetics / Q000276:immunology*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000276:immunology*; D007073:Immunoglobulin E / Q000097:blood; D007223:Infant; D008213:Lymphocyte Activation / Q000235:genetics; D008297:Male; D010047:Ovalbumin / Q000276:immunology*; D011852:Radioallergosorbent Test; D013601:T-Lymphocytes / Q000276:immunology*
D000911:Antibodies, Monoclonal; D000939:Epitopes; D006681:HLA-D Antigens; D007073:Immunoglobulin E; D010047:Ovalbumin