title: Evaluation of bone resorption: a common problem during impaired mobility.
abstract: Osteoporosis, the result of an imbalance between bone resorption and bone formation, is a potential problem for the individual with a spinal cord injury because of the immobility commonly associated with this impairment. This study was performed to determine the diagnostic value of a new assay for urinary Pyridinium crosslink (UPyr). Assays were performed on 62 first morning voided and 50 24-hour urine specimens from clients in a bone health clinic. Higher than normal levels of UPyr were observed in females with osteoporosis. UPyr correlated well with urinary hydroxyproline (r = 0.429, p = 0.005; conversely, there was an inverse relationship between bone density and UPyr (r = -0.489, p = 0.01), positive correlation (r = 0.43, p = 0.011) between the 24-hour UPyr and a serum marker of bone resorption. The study confirms that UPyr has the ability to identify states of high bone resorption. This assay should be a welcome addition to the bone health assessment of individuals with risk factors such as impaired physical mobility.
authors.forename: A H
authors.initials: AH
authors.lastname: Hunt
authors.forename: R
authors.initials: R
authors.lastname: Civitelli
authors.forename: L
authors.initials: L
authors.lastname: Halstead
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001862:Bone Resorption; D005260:Female; D006801:Humans; D007103:Immobilization / Q000009:adverse effects; D008297:Male; D008875:Middle Aged; D010024:Osteoporosis / Q000209:etiology / Q000652:urine*; D011726:Pyridinium Compounds / Q000652:urine*; D013119:Spinal Cord Injuries / Q000150:complications*
chemical_list: D011726:Pyridinium Compounds