Growth factors in renal development.
The formation of all organs during embryogenesis, including the kidney, is dependent on the timed and sequential expression of a number of polypeptide growth factors. Synthesis and actions of one or more members of the insulinlike growth factor (IGF), epidermal growth factor/transforming growth factor-alpha (EGF/TGF-alpha), transforming growth factor-beta (TGF-beta), platelet-derived growth factor (PDGF), fibroblast growth factor (FGF), hepatocyte growth factor (HGF), and nerve growth factor (NGF) families have been characterized in the developing metanephric kidney. Studies originating from a number of laboratories have defined the localization of growth factor mRNAs, receptors and peptides, have delineated patterns of growth factor synthesis, have established the growth factor-dependency of embryonic kidney development, and have identified abnormalities of growth factor-expression as potentially causative of aberrancies in metanephrogenesis. The results of these investigations are summarized in this review.
Hammerman
M R
MR
George M. O'Brien Kidney and Urological Diseases Center, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA.
D000818:Animals; D017209:Apoptosis / Q000502:physiology; D002478:Cells, Cultured; D004847:Epithelial Cells; D004848:Epithelium / Q000196:embryology / Q000502:physiology; D006133:Growth Substances / Q000096:biosynthesis / Q000502:physiology*; D006801:Humans; D007668:Kidney / Q000166:cytology / Q000196:embryology* / Q000502:physiology; D007680:Kidney Neoplasms / Q000196:embryology; D009396:Wilms Tumor / Q000196:embryology
D006133:Growth Substances