Phenotype and cancer risk of various polyposis syndromes.
The gastrointestinal polyposis syndromes are disorders with multiple intestinal polyps. Three of these disorders, familial adenomatous polyposis, Peutz-Jeghers syndrome and juvenile polyposis are associated with increased risk of colorectal as well as extracolonic cancers. A description of the phenotype and associated cancer risk is provided for each.
Giardiello
F M
FM
Johns Hopkins Hospital, Baltimore, Maryland 21287, USA.
Offerhaus
J G
JG
D011125:Adenomatous Polyposis Coli / Q000235:genetics; D000367:Age Factors; D015179:Colorectal Neoplasms / Q000209:etiology; D005770:Gastrointestinal Neoplasms / Q000235:genetics*; D006801:Humans; D007417:Intestinal Polyps / Q000235:genetics*; D010580:Peutz-Jeghers Syndrome / Q000235:genetics; D010641:Phenotype