title: Changes in serum carboxyterminal telopeptide of type I collagen in an experimental model of canine osteomyelitis.
abstract: Blood biochemical indices of bone turnover were followed up for 1 month in six dogs with experimental osteomyelitis. The bone infection resulted in significant increase in parameters of bone formation (serum bone alkaline phosphatase and serum osteocalcin) and bone resorption [serum carboxyterminal telopeptide of type I collagen (i-ICTP)] as early as the end of the second week after the operation and inoculation. There was strong evidence that serum i-ICTP levels could be useful for the early diagnosis of postoperative complications in veterinary orthopedics, such as posttraumatic osteomyelitis.
authors.affiliation: Department of Surgery, Faculty of Veterinary Medicine, Stara Zagora, Bulgaria.
authors.forename: J P
authors.initials: JP
authors.lastname: Philipov
authors.forename: M D
authors.initials: MD
authors.lastname: Pascalev
authors.forename: B Y
authors.initials: BY
authors.lastname: Aminkov
authors.forename: C D
authors.initials: CD
authors.lastname: Grosev
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001846:Bone Development; D001862:Bone Resorption; D003094:Collagen / Q000097:blood*; D024042:Collagen Type I; D004283:Dog Diseases; D004285:Dogs; D005269:Femur / Q000000981:diagnostic imaging; D015675:Osteocalcin / Q000097:blood*; D010019:Osteomyelitis / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D010455:Peptides / Q000097:blood*; D011859:Radiography
chemical_list: D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D003094:Collagen; D000469:Alkaline Phosphatase