The biochemical effects of clenbuterol: with particular reference to taurine and muscle damage.
Administration of clenbuterol to rats in the drinking water over a 4 day period increased incorporation of [3H]leucine into muscle protein and caused a slight reduction in urinary 3-methylhistidine but did not result in an increase in body or muscle weight. However, both urinary and liver taurine were significantly reduced at the highest dose of clenbuterol (2 mg.kg-1.day-1). Serum creatine kinase, muscle isoenzyme (CK-MM) was raised and single muscle fibre injury was observed in the soleus muscle in animals treated with the middle dose (0.2 mg.kg-1.day-1) and highest dose (2 mg.kg-1.day-1). The reduction in the body pool of taurine caused by clenbuterol is of concern as taurine has been shown to have protective properties.
Waterfield
C J
CJ
Department of Toxicology, School of Pharmacy, University of London, UK.
Jairath
M
M
Asker
D S
DS
Timbrell
J A
JA
D000318:Adrenergic beta-Agonists / Q000633:toxicity*; D000818:Animals; D002976:Clenbuterol / Q000633:toxicity*; D003401:Creatine / Q000652:urine; D003404:Creatinine / Q000652:urine; D004798:Enzymes / Q000097:blood; D007930:Leucine / Q000378:metabolism; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D008762:Methylhistidines / Q000652:urine; D018485:Muscle Fibers, Skeletal / Q000187:drug effects; D009124:Muscle Proteins / Q000096:biosynthesis; D009132:Muscles / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013438:Sulfhydryl Compounds / Q000097:blood; D013654:Taurine / Q000378:metabolism* / Q000652:urine
D000318:Adrenergic beta-Agonists; D004798:Enzymes; D008112:Liver Glycogen; D008762:Methylhistidines; D009124:Muscle Proteins; D013438:Sulfhydryl Compounds; D013654:Taurine; D003404:Creatinine; D007930:Leucine; C028118:3-methylhistidine; D003401:Creatine; D002976:Clenbuterol