Antimicrobial metabolites from a bacterial symbiont.
Two types of antibiotics, namely, indoles and dithiolopyrrolones, have been isolated and identified from Xenorhabdus bovienii A2. Compounds 1 and 2 showed strong activity against Cryptococcus neoformans, compounds 3 and 4 showed strong activity against Botrytis cinerea, and compounds 1, 3, and 4 showed significant activity against Phytophthora infestants (2 was not tested). In addition, two lower homologues of xenorhabdins 5 and 6, namely, 6-(N-3'-methylbutanamido)-4,5-dihydro-1,2-dithiolo[4,3-b]pyr rol-5- one [7] and 6-(N-butanamido)[4,5-dihydro-1,2-dithiolo[4,3-b]pyrrol-5-one [8], have been isolated and characterized for the first time.
Li
J
J
Department of Biological Sciences, Simon Fraser University, Burnaby, Vancouver, B.C., Canada.
Chen
G
G
Webster
J M
JM
Czyzewska
E
E
D000818:Animals; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000737:chemistry* / Q000378:metabolism; D005658:Fungi / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D008826:Microbial Sensitivity Tests; D009348:Nematoda / Q000378:metabolism / Q000382:microbiology*; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D013559:Symbiosis
D000935:Antifungal Agents