title: The effects of fasting on the thermogenic, metabolic and cardiovascular responses to infused adrenaline.
abstract: The effects of fasting on the thermogenic, lipolytic and cardiovascular responses to adrenaline were examined in nine normal, young, non-obese subjects. Each subject attended for study after 12, 36 and 72 h fasting. After basal measurements adrenaline was infused at 25 ng/min per kg ideal body weight for 90 min. Fasting increased the thermogenic effect of the adrenaline (mean 14.6 (SE 1.7), 16.6 (SE 1.8), 22.6 (SE 1.6) J/min per kg fat-free mass after 12, 36 and 72 h fasting respectively; P < 0.001, ANOVA). Basal plasma palmitate turnover increased with duration of fasting (1.48 (SE 0.22), 1.95 (SE 0.34) and 2.26 (SE 0.33) mumol/min per kg body weight; P < 0.001, ANOVA), but the response to adrenaline was unaffected by fasting. The percentage values for basal plasma palmitate turnover oxidized were 44 (SE 2; 12 h), 46 (SE 5; 36 h) and 42 (SE 4)% (72 h). In response to adrenaline this percentage fell, suggesting that adrenaline infusion may favour intra-tissue lipid oxidation.
authors.affiliation: Department of Physiology and Pharmacology, Medical School, Queen's Medical Centre, Nottingham.
authors.forename: J
authors.initials: J
authors.lastname: Webber
authors.forename: J
authors.initials: J
authors.lastname: Taylor
authors.forename: H
authors.initials: H
authors.lastname: Greathead
authors.forename: J
authors.initials: J
authors.lastname: Dawson
authors.forename: P J
authors.initials: PJ
authors.lastname: Buttery
authors.forename: I A
authors.initials: IA
authors.lastname: Macdonald
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000187:drug effects; D001833:Body Temperature Regulation / Q000187:drug effects*; D004837:Epinephrine / Q000494:pharmacology*; D005215:Fasting / Q000502:physiology*; D005260:Female; D005542:Forearm / Q000098:blood supply; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects; D008297:Male; D010168:Palmitates / Q000378:metabolism*; D012039:Regional Blood Flow / Q000187:drug effects; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D010168:Palmitates; D004837:Epinephrine