[The effect of the potential antiradiation agent compound HC-1539 on reparative DNA synthesis induced by the damaging action of the chemical mutagen N-nitroso-N-methylurea and radiation].
The influence of NS-1539, a potential anti-irradiation agent and indole analogues of tamoxifen on the DNA repair synthesis in the bone marrow and lymphocytes of peripheral blood was studied. It was found that the DNA repair processes from damages caused by chemical mutagen N-nitroso-N-methylurea or physical factor UV-irradiation in the bone marrow cells after the NS-1539 protection of mice as well as in lymphocytes of peripheral blood of human donors were enhanced. The enhancing of DNA repair synthesis was seen not earlier than 18 hours after the NS-1539 injection to mice in vivo or when NS-1539 was added to lymphocyte suspension in vitro and observed up to the third day. This period of time coincides with the time of formation of radioresistance of organism under the influence of this agent as well as with the time of realization effects of steroid hormones on target cells.
Mazurik
V K
VK
Mikhaĭlov
V F
VF
Ushenkova
L N
LN
Borovkov
M V
MV
Chernov
G A
GA
Raeva
N F
NF
D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D002273:Carcinogens / Q000494:pharmacology*; D002478:Cells, Cultured; D004249:DNA Damage / Q000187:drug effects*; D004260:DNA Repair / Q000187:drug effects* / Q000528:radiation effects*; D004305:Dose-Response Relationship, Drug; D005720:Gamma Rays; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects / Q000378:metabolism / Q000528:radiation effects; D008770:Methylnitrosourea / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D013629:Tamoxifen / Q000031:analogs & derivatives* / Q000494:pharmacology; D013997:Time Factors; D014466:Ultraviolet Rays
D002273:Carcinogens; D011837:Radiation-Protective Agents; C091454:indometafen; D013629:Tamoxifen; D008770:Methylnitrosourea
Vliianie potentsial'nogo protivoluchevogo sredstva--soedineniia HC-1539--na reparativnyĭ sintez DNK, indutsiruemyĭ povrezhdaiushchim deĭstviem khimicheskogo mutagena N-nitrozo-N-metilmocheviny i izlucheniĭ.