HLA antigens in ulcerative colitis and primary sclerosing cholangitis.
The aims of this study were to find out whether the alleles of the HLA class I or II region are associated with susceptibility to ulcerative colitis, and to show whether there is a difference or similarity in HLA associations between primary sclerosing cholangitis and ulcerative colitis. HLA-A, B, C and DR antigens were studied using the standard lymphocyte microcytotoxicity test in 24 Finnish patients with primary sclerosing cholangitis, 77 patients with ulcerative colitis, and 106 controls. HLA-B8 (54%) and DR3 (60%) were associated with primary sclerosing cholangitis. HLA-DR1 (46%) and DR6 (20%) seemed more common in ulcerative colitis than in controls. A positive association with Cw7 was common to both ulcerative colitis (25%) and primary sclerosing cholangitis (33%). Our results indicate that ulcerative colitis is more heterogeneous than primary sclerosing cholangitis in its HLA-DR associations.
Leidenius
M H
MH
Fourth Department of Surgery, Helsinki University Central Hospital, Finland.
Koskimies
S A
SA
Kellokumpu
I H
IH
Höckerstedt
K A
KA
D000293:Adolescent; D000328:Adult; D000368:Aged; D000483:Alleles; D002648:Child; D015209:Cholangitis, Sclerosing / Q000276:immunology*; D003093:Colitis, Ulcerative / Q000276:immunology*; D005260:Female; D006680:HLA Antigens / Q000032:analysis* / Q000235:genetics; D006801:Humans; D008297:Male; D008875:Middle Aged
D006680:HLA Antigens