title: De/remineralization from sodium fluoride dentifrices.
abstract: OBJECTIVE
  To test the demineralization/remineralization effects of sodium fluoride dentifrices using an in situ single-section crown model system.
  
  
  METHODS
  A fluoride dose response was evaluated using 0, 1100 and 2800 ppm F-, along with the effects of an enhanced fluoride delivery system (polyampholyte-NaF). The single-section crown model was employed with supervised toothbrushing twice a day. At the end of each 1-month study leg, sections were removed and replaced with new sections for the next leg. Both before and after the double-blind, crossover portion of the study, sections were evaluated by polarized light microscopy and microradiography. The change in mineral content of the enamel and root lesions was analyzed by ANOVA with a Waller-Duncan K-Ratio Test post hoc.
  
  
  RESULTS
  The placebo dentifrice group showed a loss of mineral and was statistically different from all groups. The fluoride dentifrices showed increasing amounts of enamel mineral gain, with increasing fluoride concentration. The polyampholyte-NaF delivery system with 1100 ppm F- was equivalent to the 2800 ppm F- dentifrice. Root lesions gave similar rank-order results although all treatments showed demineralization or mineral loss.
authors.affiliation: Dows Institute for Dental Research, College of Dentistry, University of Iowa, Iowa City 52242, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Wefel
authors.forename: M E
authors.initials: ME
authors.lastname: Jensen
authors.forename: P T
authors.initials: PT
authors.lastname: Triolo
authors.forename: R V
authors.initials: RV
authors.lastname: Faller
authors.forename: M M
authors.initials: MM
authors.lastname: Hogan
authors.forename: W D
authors.initials: WD
authors.lastname: Bowman
mesh_terms: D000328:Adult; D000665:Ampholyte Mixtures; D000704:Analysis of Variance; D002327:Cariostatic Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D018592:Cross-Over Studies; D003731:Dental Caries / Q000188:drug therapy; D003802:Dentifrices / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D016503:Drug Delivery Systems; D005260:Female; D006801:Humans; D008297:Male; D008852:Microradiography; D008859:Microscopy, Polarization; D008875:Middle Aged; D017213:Root Caries / Q000188:drug therapy; D012969:Sodium Fluoride / Q000008:administration & dosage / Q000627:therapeutic use*; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: D000665:Ampholyte Mixtures; D002327:Cariostatic Agents; D003802:Dentifrices; D012969:Sodium Fluoride