Palliative intra-arterial (i.a.) chemotherapy with carboplatin (CBDCA) and 5-FU in unresectable advanced (stage III and IV) head and neck cancer using implantable port-systems.
Intra-arterial drug therapy for head and neck cancer has been used for over 30 years. Owing to catheter-related complications occurring quite frequently this method was abandoned in many institutions. However, the development of subcutaneously implantable injection ports has renewed interest in regional drug delivery. A total of 19 injection ports have been implanted in 17 patients suffering from advanced or recurrent head and neck cancer. Regional chemotherapy was well tolerated; the predominant side effects were hemialopecia and mild unilateral mucositis. Therefore, regional, intra-arterial chemotherapy using implantable injection ports should be considered for palliative treatment of advanced head and neck cancer.
Eckardt
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Department of Oral and Maxillofacial Surgery, Hannover Medical School, Germany.
Kelber
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Pytlik
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C
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000627:therapeutic use*; D016190:Carboplatin / Q000008:administration & dosage; D002408:Catheters, Indwelling; D016503:Drug Delivery Systems / Q000295:instrumentation; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D010166:Palliative Care
D016190:Carboplatin; D005472:Fluorouracil