[A prospective randomized clinical trial comparing intra-arterial chemotherapy alone and when combined with hyperthermia for metastatic liver cancer].
To evaluate the efficacy of intra-arterial chemotherapy combined with hyperthermia for metastatic liver cancer, our cooperative study group carried out a randomized clinical trial comparing intra-arterial chemotherapy alone and intra-arterial chemotherapy combined with hyperthermia. Patients were treated with combined chemotherapy of epirubicin (EPIR), mitomycin C (MMC), 5-fluorouracil (5-FU), by hepatic infusion using a subcutaneously implanted reservoir. Hyperthermia (8MHz radiofrequency) was usually performed for 40-60 min every week, and intra-arterial chemotherapy was performed immediately before hyperthermia. Twenty-six patients were registered by telephone contact and allocated at random to groups treated with either intra-arterial chemotherapy alone (14 patients) or combination therapy (12 patients). The response rate was 7% in the chemotherapy alone group (1 PR among 14 evaluable patients), and 40% in the combination therapy group (4 PR among 10 evaluable patients). Our results suggest that intra-arterial chemotherapy combined with hyperthermia is a useful modality for the treatment of metastatic liver cancer.
Kondo
M
M
1st Dept. of Internal Medicine, Kyoto Prefectural University of Medicine.
Itani
K
K
Yoshikawa
T
T
Tanaka
Y
Y
Watanabe
N
N
Hiraoka
M
M
Noguchi
M
M
Miura
K
K
D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003110:Colonic Neoplasms / Q000473:pathology; D003131:Combined Modality Therapy; D004334:Drug Administration Schedule; D015251:Epirubicin / Q000008:administration & dosage; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D006499:Hepatic Artery; D006801:Humans; D006979:Hyperthermia, Induced; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D013274:Stomach Neoplasms / Q000473:pathology
D015251:Epirubicin; D016685:Mitomycin; D005472:Fluorouracil