title: The protein kinase C and protein kinase C related gene families.
abstract: Protein kinase C is an important target enzyme for lipid second messengers. Recent developments have focused on the tertiary structure analysis of domains present in protein kinase C and in combination with functional approaches such as mutagenesis and domain expression have generated a detailed understanding of the modular mechanism by which lipids cause activation. This provides a reference for the study of the protein kinase C-related kinases, a recently identified new class of kinases that are highly related to protein kinase C in their catalytic characteristics but have distinct regulatory features.
authors.affiliation: Protein Phosphorylation Laboratory, Imperial Cancer Research Fund, London, UK.
authors.forename: L V
authors.initials: LV
authors.lastname: Dekker
authors.forename: R H
authors.initials: RH
authors.lastname: Palmer
authors.forename: P J
authors.initials: PJ
authors.lastname: Parker
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008969:Molecular Sequence Data; D011493:Protein Kinase C / Q000737:chemistry* / Q000235:genetics; D016415:Sequence Alignment; D017421:Sequence Analysis
chemical_list: D011493:Protein Kinase C