Homocysteine as a risk factor for coronary artery disease.
This article reviews the evidence that homocysteine is a risk factor for coronary artery disease. This evidence ranges from that obtained from in-vitro experiments sometimes using non-physiological concentrations of homocysteine to epidemiological studies involving large numbers of subjects. Despite the variety of studies and methodologies employed, the hypothesis that homocysteine is a risk factor remains plausible. The relationship between certain nutrients and serum homocysteine and the therapeutic implications of this relationship are discussed.
Meleady
R A
RA
Department of Cardiology, Adelaide Hospital, Dublin, Ireland.
Graham
I M
IM
D003327:Coronary Disease / Q000209:etiology / Q000378:metabolism* / Q000628:therapy; D006710:Homocysteine / Q000097:blood / Q000378:metabolism*; D006801:Humans; D009747:Nutritional Physiological Phenomena; D012307:Risk Factors
D006710:Homocysteine