title: Tobacco-specific nitrosamines in some Nigerian cigarettes.
abstract: Ten popular brands of cigarettes on the Nigerian market were analyzed for tobacco-specific nitrosamines (TSNA) in tobacco and in mainstream smoke, as well as nitrate in tobacco. TSNA was analyzed using a gas chromatography/thermal energy analyzer (GC-TEA), while nitrate was determined spectrophotometrically as nitrite following on-line reduction with copper, diozatization with sulfanilamide and coupling with N-(1-naphthyl) ethylene diamine to form an azo dye. In mainstream smoke, the concentration of NNN, NAB/NAT and NNK were respectively, between 8 and 90 ng, 10 and 65 ng, and between 15 and 72 ng/cigarette. Preformed NNN ranged between 64 and 565 ng/cigarette, while preformed NAB/NAT and NNK ranged respectively from 109 to 476 ng/cigarette, and from 55 to 317 ng/cigarette. Nitrate levels ranged between 1.5 and 6.1 mg/g tobacco. In general, the results indicate that the TSNA content of Nigerian cigarettes are within the range found for European and American cigarettes.
authors.affiliation: Division of Toxicology and Cancer Risk Factors, German Cancer Research Centre, Heidelberg, Germany.
authors.forename: S E
authors.initials: SE
authors.lastname: Atawodi
authors.forename: R
authors.initials: R
authors.lastname: Preussmann
authors.forename: B
authors.initials: B
authors.lastname: Spiegelhalder
mesh_terms: D009538:Nicotine / Q000032:analysis; D009549:Nigeria; D009602:Nitrosamines / Q000032:analysis*; D010947:Plants, Toxic; D012906:Smoke / Q000032:analysis; D013638:Tars / Q000032:analysis; D014026:Nicotiana / Q000737:chemistry*
chemical_list: D009602:Nitrosamines; D012906:Smoke; D013638:Tars; D009538:Nicotine