title: Enzymes: chemistry and biochemistry.
abstract: Basic principles underlying enzyme action are considered. Catalytic antibodies (abzymes), catalytic RNA (ribozymes), and non-biological counterparts of enzyme-catalyzed reactions are mentioned. Enzyme evolution is considered in terms of divergence, convergence, and lateral gene transfer.
authors.affiliation: Department of Molecular and Cell Biology, University of Aberdeen, Marischal College, Scotland, UK.
authors.forename: J
authors.initials: J
authors.lastname: Jeffery
mesh_terms: D000595:Amino Acid Sequence; D000596:Amino Acids / Q000737:chemistry / Q000378:metabolism; D017151:Antibodies, Catalytic / Q000276:immunology / Q000378:metabolism*; D001665:Binding Sites; D002384:Catalysis; D003067:Coenzymes / Q000378:metabolism; D004798:Enzymes / Q000737:chemistry / Q000378:metabolism*; D019143:Evolution, Molecular; D006860:Hydrogen Bonding; D007700:Kinetics; D008670:Metals / Q000378:metabolism; D008969:Molecular Sequence Data; D011487:Protein Conformation; D016337:RNA, Catalytic / Q000235:genetics / Q000378:metabolism*
chemical_list: D000596:Amino Acids; D017151:Antibodies, Catalytic; D003067:Coenzymes; D004798:Enzymes; D008670:Metals; D016337:RNA, Catalytic