title: Cerebral proton magnetic resonance spectroscopy in Rett syndrome.
abstract: Combined MRI/MRS studies were performed in 9 girls with Rett syndrome of different ages. NAA, as marker of neuronal tissue, was found to decrease with increasing age. There was no evidence for a defective energy metabolism. The data point towards a probably secondary degenerative process in the pathogenesis of Rett syndrome.
authors.affiliation: Kinderklinik, Schwerpunkt Neuropädiatrie, Georg-August-Universität, Göttingen, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Hanefeld
authors.forename: H J
authors.initials: HJ
authors.lastname: Christen
authors.forename: U
authors.initials: U
authors.lastname: Holzbach
authors.forename: B
authors.initials: B
authors.lastname: Kruse
authors.forename: J
authors.initials: J
authors.lastname: Frahm
authors.forename: W
authors.initials: W
authors.lastname: Hänicke
mesh_terms: D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009410:Nerve Degeneration; D015518:Rett Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D012720:Severity of Illness Index