A genetic map of chromosome 11q, including the atopy locus.
Atopy is a common and genetically heterogeneous syndrome predisposing to allergic asthma and rhinitis. A locus linked to the atopy phenotype has been shown to be present on chromosome 11q12-13. Linkage has only been seen in maternally derived alleles. We have constructed a genetic linkage map of the region, using 15 markers to span approximately 27 cM, and integrate previously published maps. Under a model of maternal inheritance, the atopy locus is placed within a 7-cM interval between D11S480 and D11S451. The interval contains the important candidate gene FCERIB.
Sandford
A J
AJ
Nuffield Department of Medicine, John Radcliffe Hospital, Oxford, UK.
Moffatt
M F
MF
Daniels
S E
SE
Nakamura
Y
Y
Lathrop
G M
GM
Hopkin
J M
JM
Cookson
W O
WO
D000483:Alleles; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D003360:Cosmids; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000235:genetics*; D008297:Male; D018598:Minisatellite Repeats; D012150:Polymorphism, Restriction Fragment Length
D005819:Genetic Markers