Nephrotic syndrome, malignant thymoma, and myasthenia gravis. Case report and review of the literature.
We describe a patient with nephrotic syndrome due to focal-segmental glomerulosclerosis, occurring 3 years after thymectomy and myasthenia gravis. Nine other cases of nephrotic syndrome associated with thymoma and myasthenia gravis reported in the literature are reviewed. The nephrotic syndrome may be due to T cell dysfunction associated with thymoma; however, animal models suggest that genetic factors may also be involved.
Jayasena
S D
SD
Division of Renal Medicine, University College London Medical School, Middlesex Hospital, UK.
Woolfson
R G
RG
Griffiths
M H
MH
Neild
G H
GH
D005260:Female; D006801:Humans; D008875:Middle Aged; D009157:Myasthenia Gravis / Q000150:complications* / Q000628:therapy; D009404:Nephrotic Syndrome / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D013945:Thymoma / Q000150:complications* / Q000601:surgery; D013953:Thymus Neoplasms / Q000150:complications* / Q000601:surgery; D013997:Time Factors