Improvement by guan-mu-tong (Caulis aristolochiae manshuriensis) of lactation in mice.
Free access of 0.5% Guan-mu-tong (Gmt) as drinking water inhibited lactation of mice estimated by pup growth rate, which was associated with a decrease in RNA content and RNA/DNA ratio in the mammary glands. 0.05% Gmt improved pup growth rate and mammary DNA content. No pups were lost during the experiment. Similar results were obtained by 0.5% Xia-ru-yong-quan-tang (Xryqt), a Chinese herbal medicine, which contained 0.05% Gmt. Xryqt further prevented a decline in ovarian weight seen by 0.05% Gmt treatment and significantly increased mother weight. These findings revealed two opposite effects of Gmt on mammary glands, stimulative and inhibitory, at low- and high-dose levels, respectively.
Wu
G
G
Experimental Animal Research Laboratory, Meiji University, Kawasaki, Japan.
Yamamoto
K
K
Mori
T
T
Inatomi
H
H
Nagasawa
H
H
D000818:Animals; D001835:Body Weight / Q000187:drug effects*; D004247:DNA / Q000378:metabolism; D004326:Drinking; D005260:Female; D007774:Lactation / Q000187:drug effects*; D008516:Medicine, Chinese Traditional; D051379:Mice; D008815:Mice, Inbred Strains; D011388:Prolactin / Q000097:blood
D011388:Prolactin; D004247:DNA