title: A cohort study with regard to the risk of haematological malignancies in patients treated with x-rays for benign lesions in the locomotor system. I. Epidemiological analyses.
abstract: Roentgen treatment for painful benign conditions in the locomotor system as arthrosis and spondylosis was in Sweden very common up to the beginning of the 1960s. The mode of treatment differed from the British ankylosing spondylitis series as smaller parts of the red bone marrow were exposed and smaller doses were applied. A cohort of 20,024 such patients treated 1950-1964 at two hospitals in northern Sweden was analysed with regard to the risk of haematological malignancies. Average factors for conversion of prescribed skin doses to mean absorbed red bone marrow doses were estimated on random samples of the different treatment sites and then applied on the cohort in its whole. The standard incidence ratio (SIR) for leukaemia was 1.18 (95% CI: 0.98-1.42) and the standard mortality ratio (SMR) 1.25 (0.99-1.45). In the highest dose group (mean absorbed red bone marrow dose > 0.5 Gy) the corresponding values were 1.40 (1.00-1.92) and 1.50 (1.08-2.04). In the mortality analysis also a slightly increased myeloma risk was noted with SMR = 1.20 (0.99-1.56). Extension of the cohort and nested case-control studies are under progress.
authors.affiliation: Departments of Oncology, Umeå University, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Damber
authors.forename: L G
authors.initials: LG
authors.lastname: Larsson
authors.forename: L
authors.initials: L
authors.lastname: Johansson
authors.forename: T
authors.initials: T
authors.lastname: Norin
mesh_terms: D000328:Adult; D000368:Aged; D001853:Bone Marrow / Q000528:radiation effects; D016022:Case-Control Studies; D015331:Cohort Studies; D005260:Female; D006689:Hodgkin Disease / Q000453:epidemiology / Q000401:mortality; D006801:Humans; D015994:Incidence; D007592:Joint Diseases / Q000532:radiotherapy*; D007953:Leukemia, Radiation-Induced / Q000453:epidemiology* / Q000401:mortality; D008223:Lymphoma / Q000453:epidemiology* / Q000401:mortality; D008228:Lymphoma, Non-Hodgkin / Q000453:epidemiology / Q000401:mortality; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000453:epidemiology; D009135:Muscular Diseases / Q000532:radiotherapy*; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology* / Q000401:mortality; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012307:Risk Factors; D012867:Skin / Q000528:radiation effects; D013128:Spinal Osteophytosis / Q000532:radiotherapy; D016019:Survival Analysis; D013548:Sweden / Q000453:epidemiology