Protein phosphorylation in neuronal plasticity and gene expression.
Protein kinases and phosphatases are intimately involved in several forms of synaptic plasticity. They play a critical role in the initiation of long-term potentiation and long-term depression, as well as in the induction of genes that permit long-term expression of altered synaptic states. Recent findings demonstrate a central role for the cAMP signaling pathway in the persistent phase of long-term potentiation. Genetic approaches have established that the transcription factor CREB is essential for long-term memory.
Schulman
H
H
Department of Neurobiology, Stanford University School of Medicine, California 94305-5401, USA.
D000818:Animals; D015870:Gene Expression / Q000235:genetics*; D006624:Hippocampus / Q000378:metabolism; D015394:Molecular Structure; D009473:Neuronal Plasticity / Q000235:genetics*; D010766:Phosphorylation; D011494:Protein Kinases / Q000378:metabolism*
D011494:Protein Kinases