title: Aspirin, salicylate, sulfite and tartrazine induced bronchoconstriction. Safe doses and case definition in epidemiological studies.
abstract: Allergic-like reactions to chemical components of foods and medicines may be common. The prevalence of idiosyncratic reactions to aspirin, salicylate, metabisulfite and tartrazine is not known. We used a tertiary referral clinic population to estimate safe exposure doses for epidemiological studies. A 15% decrease in the amount of air expired in one second was defined a positive response. The median effective molar doses of the agents were remarkably similar: metabisulfite 0.19 mM, 34.4 mg [95% confidence interval (CI) 0.14, 0.27 mM]; tartrazine 0.10 M, 55.0 mg (95% CI 0.05, 0.21 mM); aspirin 0.09 mM, 16.5 mg (95% CI 0.04, 0.19 mM); and salicylate 0.11 mM, 15.3 mg (95% CI 0.05, 0.27 mM). Doses to which the most sensitive (5%) and practically all (95%) susceptible persons might respectively respond are: metabisulfite 4.6 mg, 255.8 mg; tartrazine 3.4 mg, 885.6 mg; aspirin 0.8 mg, 332.3 mg; and salicylate 2.6 mg, 89.9 mg. Doses within these ranges can be used in epidemiological studies.
authors.affiliation: Department of Medicine, Duke University, Durham, NC 27710, USA.
authors.forename: E H
authors.initials: EH
authors.lastname: Corder
authors.forename: C E
authors.initials: CE
authors.lastname: Buckley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001241:Aspirin / Q000009:adverse effects; D016084:Bronchoconstriction / Q000187:drug effects*; D004342:Drug Hypersensitivity / Q000175:diagnosis* / Q000209:etiology / Q000503:physiopathology; D004781:Environmental Exposure; D004812:Epidemiologic Methods; D005189:False Positive Reactions; D005260:Female; D005541:Forced Expiratory Volume / Q000187:drug effects; D006801:Humans; D008297:Male; D008875:Middle Aged; D012459:Salicylates / Q000009:adverse effects; D020156:Salicylic Acid; D013447:Sulfites / Q000009:adverse effects; D013645:Tartrazine / Q000009:adverse effects
chemical_list: D012459:Salicylates; D013447:Sulfites; C030981:metabisulfite; D013645:Tartrazine; D020156:Salicylic Acid; D001241:Aspirin