[Effects of medical vagotomy and sympathectomy on gastric mucosal prostaglandins in water immersion restrain rats].
Ulcer index (UI), gastric submucosal blood flow (SMBF), gastric fundic mucosal content of 5 prostaglandins (PGE2, TXB2, PGF2 alpha, PGD2, 6-keto-PGF1 alpha) were measured in water immersion restrain rats under medical vagotomy (MV) or medical sympathectomy (MSp). UI decreased under MV and MSp with 6 hours stress. SMBF decreased less under MV and MSp than control rats. PGE2 of control rats decreased under stress, but increased under MV and MSp. It is resulted that MV and MSp effect PGE2 to increase, inhibition of SMBF decreasing because of increasing PGE2 were recognised and there for stress ulcer were inhibited.
Tanaka
M
M
First Department of Surgery, Juntendo University School of Medicine.
D000818:Animals; D015232:Dinoprostone / Q000378:metabolism; D005753:Gastric Mucosa / Q000098:blood supply / Q000378:metabolism*; D007101:Immersion; D008297:Male; D011453:Prostaglandins / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012039:Regional Blood Flow; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000209:etiology / Q000378:metabolism*; D013312:Stress, Physiological / Q000378:metabolism*; D013563:Sympathectomy, Chemical; D013564:Sympathetic Nervous System / Q000502:physiology*; D014628:Vagotomy
D011453:Prostaglandins; D015232:Dinoprostone