title: Stopped for repairs.
abstract: The tumor suppressor protein p53 is intimately involved in the cellular response to DNA damage, controlling cell cycle arrest, apoptosis and the transcriptional induction of DNA damage inducible genes. A transcriptional target of p53, Gadd45, was recently found to bind to PCNA, a component of DNA replication/repair complexes, thereby implicating Gadd45 in DNA metabolism. Using biochemical assays, a role for Gadd45 in excision repair in vitro has been demonstrated. Antisense experiments have also indicated an in vivo role for the GADD45 gene in UV-irradiation survival. These discoveries establish a link between p53 and DNA repair through Gadd45.
authors.affiliation: Howard Hughes Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Sanchez
authors.forename: S J
authors.initials: SJ
authors.lastname: Elledge
mesh_terms: D000818:Animals; D017209:Apoptosis; D002453:Cell Cycle; D004249:DNA Damage; D004260:DNA Repair; D004261:DNA Replication; D015870:Gene Expression; D006801:Humans; D008322:Mammals; D008954:Models, Biological; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D014158:Transcription, Genetic
chemical_list: D018809:Proliferating Cell Nuclear Antigen