[Somatostatin and growth hormone in post-colectomy intestinal hyperplasia in rats].
OBJECTIVE
Somatostatin exerts significant effects on gastrointestinal function that may include mucosal growth regulation, probably through its action on growth hormone release. The aim of this work was to correlate somatostatin and growth hormone plasma levels and the hyperproliferative status of intestinal mucosa after colectomy.


METHODS
Adult Wistar rats were divided into two groups: control sham operated (n = 8) and large bowel resection (n = 8). Seven days post-colectomy, the animals were killed. Ileal mucosal samples were assayed for proliferative status (morphometry, and proliferating cell nuclear antigen labeling) and blood samples for plasmatic somatostatin and growth hormone measurement.


RESULTS
A hyperproliferative status was observed with significant increases in villous length and crypt proliferating cell nuclear antigen labeling. Plasma somatostatin showed a 95% significant decrease while growth hormone levels increased significantly.


CONCLUSIONS
The intestinal adaptation seen after colectomy is associated with lower somatostatin and higher growth hormone plasma level, possibly by regulating the intestinal adaptative process.
De Miguel
E
E
Servicio de Cirugía Experimental, Hospital La Paz, Madrid.
Gómez de Segura
I A
IA
Aguilera
M J
MJ
Codesal
J
J
Codoceo
R
R
D000818:Animals; D003082:Colectomy / Q000009:adverse effects*; D013006:Growth Hormone / Q000097:blood*; D006965:Hyperplasia / Q000097:blood / Q000209:etiology; D007082:Ileum / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000097:blood*
D013004:Somatostatin; D013006:Growth Hormone
Somatostatina y hormona de crecimiento en la hiperplasia intestinal post-colectomía en la rata.