[Cell cycle regulation by anticancer agent].
Some anticancer agents induce cell cycle arrest. We analyzed the effect of anticancer agents on cell-cycle regulators, such as CDK. Our data suggested that arresting cells in the G2-phase of the cell cycle by cisplatin might be regulated by dephosphorylation of cdc2 kinase. Butyrolactone I inhibits both cdc2 and CDK2 kinase in the cell-free system. The cytotoxic effect of paclitaxel shows mainly in the M-phase of the cell cycle. Suramin inhibits cdc2 kinase. UCN-01, a protein kinase-C inhibitor, also inhibits both cdc2 and CDK2 kinase. Some anticancer agents induce apoptosis.
Nomoto
T
T
Pharmacology Division, National Cancer Center Research Institute, Tokyo.
Nishio
K
K
Saijo
N
N
D000970:Antineoplastic Agents / Q000494:pharmacology*; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D017209:Apoptosis / Q000187:drug effects; D002453:Cell Cycle / Q000187:drug effects* / Q000502:physiology; D002474:Cell-Free System; D002945:Cisplatin / Q000494:pharmacology; D018844:Cyclin-Dependent Kinases / Q000502:physiology*; D016195:G2 Phase; D006801:Humans; D017239:Paclitaxel / Q000494:pharmacology; D013498:Suramin / Q000494:pharmacology
D000970:Antineoplastic Agents; D000972:Antineoplastic Agents, Phytogenic; D013498:Suramin; D018844:Cyclin-Dependent Kinases; D017239:Paclitaxel; D002945:Cisplatin