Steroid inhibition of cytokine-mediated vasodilation after warm heart surgery.
BACKGROUND
Peripheral vasodilation, a potentially adverse effect of warm heart surgery, may be mediated by the perioperative release of cytokines. Corticosteroids may abolish cytokine production and vasodilation. We investigated cytokine production and its inhibition by steroids in patients undergoing elective coronary bypass surgery.


RESULTS
Twenty-five patients undergoing coronary bypass surgery with normothermic cardiopulmonary bypass received either preoperative steroid (Solumedrol 250 mg IV, n = 16) or no steroid (n = 9, control group). Blood samples were obtained serially for 24 hours and assayed for interleukin-6 (IL-6), tumor necrosis factor (TNF), and interleukin-8 (IL-8). In the control patients, the IL-6, TNF, and IL-8 levels were elevated postoperatively and peaked between 3 and 6 hours after surgery (IL-6, 1330 +/- 295 [mean +/- SEM] pg/mL; TNF, 18.4 +/- 9.8 pg/mL; and IL-8, 150 +/- 51 pg/mL). Cytokine release was abolished in patients receiving preoperative corticosteroid (IL-6, 75 +/- 38 pg/mL; TNF, 2.6 +/- 0.5 pg/mL; and IL-8, 33 +/- 6.7 pg/mL; P < .05). Patients receiving steroid premedication had higher arterial pressure, lower cardiac index, and higher systemic vascular resistance, indicating less vasodilation.


CONCLUSIONS
Our findings demonstrate that cytokine production occurs after normothermic cardiopulmonary bypass. Preoperative administration of steroids abolishes cytokine release and vasodilation.
Teoh
K H
KH
Department of Medicine, McMaster University, Hamilton, Ontario, Canada.
Bradley
C A
CA
Gauldie
J
J
Burrows
H
H
D002315:Cardiopulmonary Bypass; D001026:Coronary Artery Bypass; D016207:Cytokines / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006358:Hot Temperature; D006801:Humans; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology* / Q000627:therapeutic use; D008875:Middle Aged; D011184:Postoperative Period; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D014664:Vasodilation / Q000187:drug effects*
D016207:Cytokines; D015850:Interleukin-6; D016209:Interleukin-8; D014409:Tumor Necrosis Factor-alpha; D008775:Methylprednisolone