Unusual findings in a fatal case of poisoning with chromate compounds.
An interesting case of acute poisoning by chromate compounds is reported. A 51-year-old man committed suicide by ingesting a fatal dose of sodium chromate solution. He unexpectedly lost consciousness 6 h after the ingestion and died approximately 20.5 h later. An examination of the blood showed noticeable hepatic damage and thrombocytopenia. The postmortem examination revealed extensive bleeding in the alimentary tract and a severe hepatic lesion due to hepatocellular necrosis. However, the renal disorder was unusually light in the microscopic and clinical findings. Moreover, the renal lesion was observed mainly in the distal tubules instead of the proximal tubules which is more typical in cases of acute poisonings by diverse heavy metals including chromium. The patient's death was assumed to have been caused by circulatory collapse due to internal bleeding and the direct toxicity of chromate compounds with hepatic malfunction and possibly disseminated intravascular coagulation (DIC).
Kurosaki
K
K
Department of Legal Medicine, School of Medicine, Chiba University, Japan.
Nakamura
T
T
Mukai
T
T
Endo
T
T
D056486:Chemical and Drug Induced Liver Injury; D002840:Chromates / Q000506:poisoning*; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000473:pathology*; D008107:Liver Diseases / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D017670:Sodium Compounds / Q000506:poisoning*; D013405:Suicide
D002840:Chromates; D017670:Sodium Compounds; C028982:sodium chromate(VI)