[Clinical effects and immunological analysis of intraabdominal and intrapleural injection of lentinan for malignant ascites and pleural effusion of gastric carcinoma].
Twenty-one patients with malignant peritoneal or pleural effusions of gastric carcinomas were treated with intracavitary injection of lentinan (LNT). LNT was injected at a dosage of 4 mg/week for 4 weeks. In total, fifteen (71%) of twenty-one patients demonstrated clinical responses. Toxicity caused a high fever in only one case. LAK and ATK activities induced from peritoneal exudate cells (PEC) after culture with autologous tumor and interleukin-2 were examined before and after LNT injection. ATK activity was augmented, but LAK activity was reduced after LNT injection. These results indicate that intracavitary injection of LNT is a useful treatment for malignant effusions, and that LNT augments the induction of cytotoxic T-lymphocytes.
Hazama
S
S
Dept. of Surgery II, Yamaguchi University School of Medicine.
Oka
M
M
Yoshino
S
S
Iizuka
N
N
Wadamori
K
K
Yamamoto
K
K
Hirazawa
K
K
Wang
F
F
Ogura
Y
Y
Masaki
Y
Y
D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001202:Ascitic Fluid / Q000276:immunology* / Q000628:therapy; D006801:Humans; D015552:Injections, Intralesional; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D007912:Lentinan / Q000627:therapeutic use*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D016066:Pleural Effusion, Malignant / Q000276:immunology* / Q000628:therapy; D013274:Stomach Neoplasms / Q000150:complications*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D000972:Antineoplastic Agents, Phytogenic; D007912:Lentinan