title: [Increased plasma level of Type I (p55) and Type II (p75) TNF-receptors following trauma].
abstract: Excessive synthesis and release of proinflammatory cytokines following trauma have been correlated with poor outcome of injured patients. TNF-alpha seems to play a pivotal role as trigger for the induction of systemic inflammation. Recently, two naturally occurring inhibitors of TNF-alpha, soluble TNF-receptors (sTNFRs) p55 and p75, have been characterized. The present study was undertaken to determine whether severe trauma increases circulating sTNFRs dependent on severity of injury. Injured patients (n = 190) revealed significantly increased plasma levels of both sTNFRs throughout the observation period of 21 days compared to healthy volunteers (n = 125). Patients with severe injury (ISS > 16 pts; n = 130) revealed higher (p < 0.0001) levels of sTNFRs on day of admission than patients with minor trauma (< or = 16 pts; n = 60). Thus, anti-inflammatory mechanisms are activated during the posttraumatic course dependent on severity of injury.
authors.affiliation: Departement Chirurgie, Universitätsspital, Zürich.
authors.forename: M
authors.initials: M
authors.lastname: Keel
authors.forename: M
authors.initials: M
authors.lastname: Bonaccio
authors.forename: U
authors.initials: U
authors.lastname: Steckholzer
authors.forename: U
authors.initials: U
authors.lastname: Ungethüm
authors.forename: H
authors.initials: H
authors.lastname: Gallati
authors.forename: O
authors.initials: O
authors.lastname: Trentz
authors.forename: W
authors.initials: W
authors.lastname: Ertel
mesh_terms: D000328:Adult; D006801:Humans; D015601:Injury Severity Score; D018124:Receptors, Tumor Necrosis Factor / Q000096:biosynthesis* / Q000302:isolation & purification; D014947:Wounds and Injuries / Q000097:blood* / Q000145:classification
chemical_list: D018124:Receptors, Tumor Necrosis Factor
vernacular_title: Erhöhte Plasmaspiegel der löslichen TNF-Rezeptoren (sTNFRs) Typ I (p55) und Typ II (p75) nach Trauma.