title: Plant-derived triterpenoid sweetness inhibitors.
abstract: Considerable recent attention has been focused on naturally occurring compounds with taste-modifying activity, which are of potential use in both dietary sweetness management and in gaining a better understanding of the sweet taste sensation. This review summarizes information on the phytochemistry and biological activity of more than 40 triterpenoid sweetness inhibitors that have been isolated from the leaves of three medicinal plants, namely, Gymnema sylvestre R.Br. (Asclepiadaceae), Ziziphus jujuba P. Miller (Rhamnaceae), and Hovenia dulcis Thunb. (Rhamnaceae).
authors.affiliation: Department of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, University of Illinois at Chicago 60612, USA.
authors.forename: R
authors.initials: R
authors.lastname: Suttisri
authors.forename: I S
authors.initials: IS
authors.lastname: Lee
authors.forename: A D
authors.initials: AD
authors.lastname: Kinghorn
mesh_terms: D004336:Drug Antagonism; D005947:Glucose / Q000378:metabolism; D007408:Intestinal Absorption / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D018515:Plant Leaves / Q000378:metabolism; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship; D013549:Sweetening Agents / Q000737:chemistry*; D013649:Taste / Q000187:drug effects*; D013729:Terpenes / Q000378:metabolism / Q000494:pharmacology*
chemical_list: D010936:Plant Extracts; D013549:Sweetening Agents; D013729:Terpenes; D005947:Glucose