[Seroprevalence of HTLV-I in relatives of patients with spastic paraparesis (HAM/TSP and PEP)].
The seroprevalence of HTLV-1 was studied in parents, brothers, siblings and sexual partners of 147 patients with spastic paraparesis associated to HTLV-1 (HAM/TSP) and 84 patients with HTLV-1 negative spastic paraparesis (SP). Seroprevalence was 29.1% for HAM/SP and 0% for SP relatives (p < 0.001); the last figure is similar to that of the general population. Seroprevalence in sexual partners was 65%, suggesting that sexual intercourse is the principal route of transmission. Likewise, seroprevalence in siblings of mothers with HAM/TSP or HTLV-1 positive was 17.6%, suggesting a high maternal transmission.
Cartier
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Departamento de Ciencias Neurológicas, Facultad de Medicina, Universidad de Chile, Santiago de Chile.
Vergara
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Ramírez
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E
Casivar
T
T
Vásquez
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003430:Cross-Sectional Studies; D005192:Family Health; D005260:Female; D015490:HTLV-I Infections / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology / Q000635:transmission; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged; D015493:Paraparesis, Tropical Spastic / Q000453:epidemiology* / Q000235:genetics / Q000276:immunology / Q000635:transmission; D015995:Prevalence; D016036:Seroepidemiologic Studies
Seroprevalencia del HTLV-I en familiares de pacientes con paraparesia espástica (HAM/TSP y PEP).