title: Expression of Na, K-ATPase alpha and beta isoforms in the neonatal rat cochlea.
abstract: The postnatal expression of five Na, K-ATPase alpha (alpha 1, alpha 2, alpha 3) and beta (beta 1, beta 2) subunit isoforms in the rat cochlea was investigated by immunocytochemistry. High levels of expression of the alpha 1 and beta 2 isoforms were observed in stria vascularis (SV) at all developmental stages. alpha 1 and beta 1 isoforms showed a distinct time-dependent developmental expression pattern in tissues of the spiral ligament (SL) and spiral limbus (SLi). Limited, temporary expression of alpha 2 and alpha 3 subunit isoforms were found in SV and SL. Expression of each isoform was also seen in organ of Corti (OC), spiral ganglion (SG), cochlear nerve (CN) and Kölliker's Organ (KO). These observations suggest that individual isoforms may exert specific actions postnatally during final cochlear maturation.
authors.affiliation: Departments of Anatomy & Cell Biology and Otolaryngology, College of Medicine, University of Florida, Gainesville, USA.
authors.forename: J
authors.initials: J
authors.lastname: Zuo
authors.forename: L M
authors.initials: LM
authors.lastname: Curtis
authors.forename: X
authors.initials: X
authors.lastname: Yao
authors.forename: W J
authors.initials: WJ
authors.lastname: Ten Cate
authors.forename: K E
authors.initials: KE
authors.lastname: Rarey
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003051:Cochlea / Q000737:chemistry* / Q000166:cytology* / Q000502:physiology; D003056:Cochlear Nerve / Q000737:chemistry / Q000166:cytology; D007150:Immunohistochemistry; D009925:Organ of Corti / Q000737:chemistry / Q000166:cytology; D010784:Photomicrography; D012333:RNA, Messenger; D051381:Rats; D000254:Sodium-Potassium-Exchanging ATPase / Q000032:analysis*; D013136:Spiral Ganglion / Q000737:chemistry / Q000166:cytology
chemical_list: D012333:RNA, Messenger; D000254:Sodium-Potassium-Exchanging ATPase