Promotion by SR 48692 of gastric emptying and defaecation in rats suggesting a role of endogenous neurotensin.
We investigated the influence of the nonpeptide neurotensin receptor antagonist, SR 48692, administered orally, on gastric emptying and on acute defaecation. SR 48692 dose-dependently (ED50 approximately 0.7 microgram kg-1) increased gastric emptying of a food suspension, but it had no effect on that of a non-caloric meal. SR 48692 also dose-dependently promoted defaecation and increased faecal water content. We suggest that antagonism of endogenous neurotensin accounts for the gastric emptying and defaecation promoting action of SR 48692.
Croci
T
T
SANOFI-Midy S.p.A. Research Center, Milan, Italy.
Giudice
A
A
Manara
L
L
Gully
D
D
Le Fur
G
G
D000284:Administration, Oral; D000818:Animals; D003672:Defecation / Q000187:drug effects*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005243:Feces / Q000737:chemistry; D005508:Food Deprivation; D005746:Gastric Emptying / Q000187:drug effects*; D007211:Indoles / Q000008:administration & dosage / Q000494:pharmacology; D007279:Injections, Subcutaneous; D008297:Male; D011720:Pyrazoles / Q000008:administration & dosage / Q000494:pharmacology*; D011804:Quinolines / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018028:Receptors, Neurotensin / Q000037:antagonists & inhibitors*; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology; D000077526:Tropisetron; D014867:Water / Q000378:metabolism
D007211:Indoles; D011720:Pyrazoles; D011804:Quinolines; D018028:Receptors, Neurotensin; D012702:Serotonin Antagonists; D014867:Water; C079087:SR 48692; D000077526:Tropisetron