[The effect of bromantane on the dopamin- and serotoninergic systems of the rat brain].
The effect of acute and chronic administration (50 mg/kg, p.o.) of a new immunostimulator, bromantan exhibiting psychostimulant features on the content of NE, DA and 5-HT, and their metabolites are studied. Bromantan induced a significant increase in the 5-HT and 5-HIAA content in the frontal cortex and delayed an increase in their content in subcortical brain regions. A stable decrease in the 5-HT and 5-HIAA levels in the cerebellum is observed. The drug also affected the DA parameters of the brain thus suggesting an important role of dopaminergic system in the mechanism of pharmacological effects of the drug.
Kudrin
V S
VS
Sergeeva
S A
SA
Krasnykh
L M
LM
Miroshnichenko
I I
II
Grekhova
T V
TV
Gaĭnetdinov
R R
RR
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000547:Amantadine / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D008297:Male; D011092:Polyethylene Glycols / Q000494:pharmacology; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D011954:Receptors, Dopamine / Q000032:analysis / Q000187:drug effects*; D011985:Receptors, Serotonin / Q000032:analysis / Q000187:drug effects*; D012997:Solvents / Q000494:pharmacology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D011619:Psychotropic Drugs; D011954:Receptors, Dopamine; D011985:Receptors, Serotonin; D012997:Solvents; D011092:Polyethylene Glycols; D000547:Amantadine; C085955:bromantane
Vliianie bromantana na dofamin- i serotoninergicheskie sistemy mozga krys.