title: Prognostic factors for survival and disease-free survival in hepatic metastases from colorectal cancer treated by resection.
abstract: The prognostic factors of 219 patients submitted to Ro hepatic resection for colorectal metastases have been statistically analyzed. The overall 5-year actuarial survival rate was 24% and the 5-year disease-free survival rate was 18%. At univariate analysis four variables resulted significant: 1) The stage of primary colorectal cancer: if the meserentic lymph nodes were metastatic (Dukes C) or uninvolved (Dukes B) 5-year survival was respectively 16 and 38% (p < 0.001). 2) The percentage of hepatic replacement: the 5-year survival rate of patients with H1 (< 25%), H2 (25-50%) and H3 (> 50%) was 27, 16 and 8% respectively (p < 0.001). 3) The number of metastases: the 5-year survival of patients with 1, 2-3, > 3 hepatic nodules was 29, 21 and 17% respectively (p < 0.05). 4) The extent of surgical resection: 5-year survival after minor and major resection was 28 and 18% respectively (p < 0.05). At multivariate analysis only stage of primary and percentage of hepatic replacement retained statistical significance. In 60% of 154 patients with recurrent disease the liver was again involved.
authors.affiliation: Divisione di Chirurgia dell'Apparato Digerente, Istituto Nazionale Tumori, Milano, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Doci
authors.forename: P
authors.initials: P
authors.lastname: Bignami
authors.forename: F
authors.initials: F
authors.lastname: Montalto
authors.forename: L
authors.initials: L
authors.lastname: Gennari
mesh_terms: D000704:Analysis of Variance; D015179:Colorectal Neoplasms / Q000473:pathology* / Q000601:surgery*; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D015993:Life Tables; D008113:Liver Neoplasms / Q000556:secondary* / Q000601:surgery*; D008297:Male; D015999:Multivariate Analysis; D011379:Prognosis; D016016:Proportional Hazards Models; D012307:Risk Factors; D016019:Survival Analysis