Structure of the gene encoding the mouse pituitary adenylate cyclase-activating polypeptide receptor.
The PACAP-R gene, encoding the mouse pituitary adenylate cyclase-activating polypeptide receptor (PACAP-R), has been isolated and its structural organization has been determined. PACAP-R spans more than 50 kb and is divided into 18 exons. PACAP-R contains two alternative exons encoding the putative third intracellular loop, as found in the rat PACAP-R. The proximal promoter region is highly G+C rich and lacks an apparent TATA box, but contains a CCAAT box and two potential Sp1-binding sites.
Aino
H
H
Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka University, Japan.
Hashimoto
H
H
Ogawa
N
N
Nishino
A
A
Yamamoto
K
K
Nogi
H
H
Nagata
S
S
Baba
A
A
D000818:Animals; D001482:Base Composition; D001483:Base Sequence; D001665:Binding Sites; D004247:DNA / Q000737:chemistry / Q000235:genetics; D005091:Exons; D005809:Genes, Regulator; D051379:Mice / Q000235:genetics*; D008969:Molecular Sequence Data; D008970:Molecular Weight; D011401:Promoter Regions, Genetic; D051381:Rats; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D011979:Receptors, Pituitary Hormone / Q000096:biosynthesis / Q000235:genetics*; D015183:Restriction Mapping; D016329:Sp1 Transcription Factor / Q000378:metabolism; D016385:TATA Box
C495504:Adcyap1r1 protein, mouse; D051236:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide; D051237:Receptors, Pituitary Adenylate Cyclase-Activating Polypeptide, Type I; D011979:Receptors, Pituitary Hormone; D016329:Sp1 Transcription Factor; D004247:DNA