[Changes in the activity of an epileptogenic focus in the rat hippocampus under the influence of bemitil].
Experiments performed on male rats with chronically implanted electrochemotrodes showed bemitil (12.5 and 25.0 mg/kg, intra-abdominally, 24 h prior to the locus creation) suppresses he pathological activity of (100 ED) epileptogenic locus induced by he sodium salt of penicillin in the hippocampus of the animals. Probable mechanisms of antiepileptic action of bemitil are considered.
Mikhaĭlov
I B
IB
Sharf
M Ia
MIa
Guzeva
V I
VI
D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology / Q000627:therapeutic use*; D001562:Benzimidazoles / Q000494:pharmacology / Q000627:therapeutic use*; D003292:Convulsants; D003864:Depression, Chemical; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects; D004828:Epilepsies, Partial / Q000139:chemically induced / Q000188:drug therapy* / Q000503:physiopathology; D006624:Hippocampus / Q000187:drug effects* / Q000503:physiopathology; D007274:Injections, Intraperitoneal; D008297:Male; D010400:Penicillin G; D051381:Rats
D000927:Anticonvulsants; D001562:Benzimidazoles; D003292:Convulsants; C049825:bemethyl; D010400:Penicillin G
Izmenenie aktivnosti épileptogennogo ochaga v gippokampe krys pod vliianiem bemitila.