[Clinical aspects of drug-induced tubulo-interstitial nephropathy].
It is well known that many drugs can induce tubulointerstitial nephropathy (DTIN) in the kidney. There are two kinds of onset mechanisms such as dose-dependent and allergic nephropathy. Risk factors inducing DTIN are known as aging, dehydration, preexisting renal damage, hypertension and serum electrolyte abnormalities. Treatment of DTIN is firstly to cease suggestive drugs of inducing nephropathy and then followed by diuresis, correcting serum electrolyte levels and sometimes hemodialysis or hemoadsorption to reduce the suggested drug levels in the circulation. In allergic nephropathy, high-dose glucocorticoid therapy is available for improving renal function rapidly. The prevention of DTIN is to know the patients background and monitor serum drug levels.
Shibasaki
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Second Department of Internal Medicine, Jikei University School of Medicine.
D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000175:diagnosis / Q000628:therapy; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal