title: An MR compatible flow simulator for intravascular pressure simulation.
abstract: An MR compatible flow simulator is described which generates physiologically realistic pressure and flow waveforms. The simulator is based on a servomotor-driven gear pump which produces pulsatile flow by modulation of the servomotor rotation rate. Operation of the simulator is under the control of a personal computer, which executes an iterative feedback loop to minimize errors between measured and desired pressure waveforms. The simulator is totally automatic, requiring only a few minutes of iteration to generate the desired pressure waveform. Accurate sinusoidal waveforms with frequencies up to 10 Hz have been generated using the simulator, with high-frequency contamination of the measured waveform at least 80 dB below the fundamental frequency. Aortic waveforms have been produced with realistic flow rates and pressure variations. The pump assembly is mechanically straightforward and can operate at an 8-m distance from the flow phantom to allow the device to be isolated from the MR magnet room.
authors.affiliation: Department of Medical Biophysics, Sunnybrook Health Science Centre, University of Toronto, Ontario, Canada.
authors.forename: D B
authors.initials: DB
authors.lastname: Plewes
authors.forename: S N
authors.initials: SN
authors.lastname: Urchuk
authors.forename: S
authors.initials: S
authors.lastname: Kim
authors.forename: I
authors.initials: I
authors.lastname: Soutar
mesh_terms: D055592:Biophysical Phenomena; D001703:Biophysics; D001783:Blood Flow Velocity / Q000502:physiology; D001794:Blood Pressure / Q000502:physiology*; D003198:Computer Simulation; D005069:Evaluation Studies as Topic; D006801:Humans; D008279:Magnetic Resonance Imaging / Q000295:instrumentation*; D008955:Models, Cardiovascular; D011673:Pulsatile Flow / Q000502:physiology