title: Ochronotic arthropathy: rapid destructive hip osteoarthritis associated with metabolic disease.
abstract: Ochronosis is a musculoskeletal manifestation of alkaptonuria, an inherited metabolic disorder associated with various systemic abnormalities related to the deposition of homogentisic acid pigment in connective tissues. This report describes a 58-year-old woman with ochronotic arthropathy who, in addition to the typical clinical features of the disorder, presented with rapidly progressive hip osteoarthritis. The destruction of the joint architecture and the severe functional impairment necessitated a total hip replacement which resulted in a satisfactory outcome.
authors.affiliation: Department of Physical Therapy and Rehabilitation, Clinica del Lavoro Foundation, Veruno, Novara, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Corrà
authors.forename: M
authors.initials: M
authors.lastname: Zaccala
authors.forename: M
authors.initials: M
authors.lastname: Galante
mesh_terms: D000474:Alkaptonuria / Q000150:complications* / Q000000981:diagnostic imaging / Q000503:physiopathology; D005260:Female; D006801:Humans; D008875:Middle Aged; D009794:Ochronosis / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D015207:Osteoarthritis, Hip / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D011859:Radiography