Comparison of methods of estimating the mother-to-child transmission rate of human immunodeficiency virus type 1 (HIV-1). New York City Perinatal HIV Transmission Collaborative Study Group.
Four methods of estimating mother-to-child transmission rates of human immunodeficiency virus type 1 (HIV-1), based on the 1992 Ghent workshop, were compared in a multicenter New York City prospective cohort study in 1986-1992. Of 833 infants born to women at risk of HIV-1 infection, 388 were born HIV-1 seropositive and 445 were HIV-1 seronegative. The four methods, the Antibody Only, Indirect, Direct, and Virologic Methods, yielded transmission rate estimates of 19-25%, classifying 59-89% of the cohort. Estimation based on persistence of HIV-1 antibody and clinical assessment yielded transmission rates similar to those methods that incorporated virologic testing.
Matheson
P B
PB
Medical and Health Research Association of New York City, Inc., NY.
Weedon
J
J
Cappelli
M
M
Abrams
E J
EJ
Shaffer
N
N
Bamji
M
M
Krasinski
K
K
Lambert
G
G
Kaul
A
A
Grimm
K
K
D000328:Adult; D015153:Blotting, Western; D002675:Child, Preschool; D003627:Data Interpretation, Statistical; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D015497:HIV-1; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D009519:New York City / Q000453:epidemiology; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000097:blood / Q000453:epidemiology / Q000821:virology; D011446:Prospective Studies; D016036:Seroepidemiologic Studies