Acute hemolysis during cyclosporine therapy successfully treated with vitamin E.
The immunosuppressant cyclosporine induces acute hemolysis (hemolytic uremic syndrome) in some patients after transplantation, possibly because of its effects on the vascular endothelium. We report a case of Coombs-negative, non-immune severe hemolytic anemia during cyclosporine therapy after allogeneic bone marrow transplantation for severe aplastic anemia. Uremia was not observed. Vitamin E was effective in treating the intravascular hemolysis.
Azuma
E
E
Department of Pediatrics and Clinical Immunology, Mie University School of Medicine, Japan.
Hirayama
M
M
Nakano
T
T
Nagai
M
M
Hiratake
S
S
Komada
Y
Y
Sakurai
M
M
D000208:Acute Disease; D000293:Adolescent; D000741:Anemia, Aplastic / Q000628:therapy*; D000743:Anemia, Hemolytic / Q000188:drug therapy* / Q000209:etiology; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D016572:Cyclosporine / Q000009:adverse effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000009:adverse effects*; D008297:Male; D014810:Vitamin E / Q000627:therapeutic use*
D007166:Immunosuppressive Agents; D014810:Vitamin E; D016572:Cyclosporine