title: An intermediate for chloroquine analogs: (E)-2-(4,7-dichloro-2-quinolinyl)-3-(dimethylamino)-2-propenal.
abstract: The title compound C14H12C12N2O, has been shown to have an E configuration about the double bond in the propenal moiety. Significant delocalization of the lone pair on the N atom of the dimethylamino group into the pi system of this moiety is indicated by the planarity about this N atom.
authors.affiliation: Department of Chemistry, Tulane University, New Orleans, Louisiana 70118, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Mague
authors.forename: D
authors.initials: D
authors.lastname: De
authors.forename: D J
authors.initials: DJ
authors.lastname: Krogstad
mesh_terms: D000171:Acrolein / Q000031:analogs & derivatives* / Q000737:chemistry; D000962:Antimalarials / Q000737:chemistry*; D002738:Chloroquine / Q000031:analogs & derivatives*; D018360:Crystallography, X-Ray; D011804:Quinolines / Q000737:chemistry*; D013237:Stereoisomerism
chemical_list: C096578:2-(4,7-dichloro-2-quinolinyl)-3-(dimethylamino)-2-propenal; D000962:Antimalarials; D011804:Quinolines; D000171:Acrolein; C035317:4,7-dichloroquinoline; D002738:Chloroquine