title: Tuberculosis and invasive pulmonary aspergillosis in a young woman with a myelodysplastic syndrome.
abstract: A 29-year-old Chinese woman developed pyrexia, multiple skin abscesses and bilateral fine nodular lung infiltrates about 3 months after the commencement of therapy for idiopathic thrombocytopenic purpura (ITP). Pseudomonas aeroginosa was isolated from the abscesses but multiple blood and sputum cultures, as well as a broncho-alveolar lavage did not yield any microorganisms. The persistence of fever and pulmonary infiltrates warranted an open lung biopsy which provided a definitive diagnosis of tuberculous-aspergillus granulomatous lung disease. Bone marrow re-examination revised the primary haematological disorder to that of a trisomy 8 associated myelodysplastic syndrome.
authors.affiliation: Department of Medicine, National University Hospital, Singapore.
authors.forename: Y K
authors.initials: YK
authors.lastname: Kueh
authors.forename: S B
authors.initials: SB
authors.lastname: Chionh
authors.forename: T Y
authors.initials: TY
authors.lastname: Ti
authors.forename: W C
authors.initials: WC
authors.lastname: Tan
authors.forename: Y S
authors.initials: YS
authors.lastname: Lee
mesh_terms: D000328:Adult; D000995:Antitubercular Agents / Q000627:therapeutic use; D001228:Aspergillosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D005260:Female; D016469:Fungemia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006105:Granulomatous Disease, Chronic / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D008172:Lung Diseases, Fungal / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D009190:Myelodysplastic Syndromes / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D014376:Tuberculosis / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy
chemical_list: D000995:Antitubercular Agents