Gonadotropin-releasing hormone neurons in the rhesus macaque are not immunoreactive for the estrogen receptor.
The issue of whether gonadotropin-releasing hormone (GnRH) neurons in the primate contain the estrogen receptor was examined by immunocytochemistry using prepubertal and adult (intact and ovariectomized) female rhesus macaques. No GnRH neurons were found to contain nuclei that were immunoreactive for the estrogen receptor. These results confirm in primates what has been reported in other species and leave open the question of how the effects of gonadal steroids on GnRH neurons are mediated.
Sullivan
K A
KA
Department of Neurology, University of Michigan, Ann Arbor, USA.
Witkin
J W
JW
Ferin
M
M
Silverman
A J
AJ
D000818:Animals; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000032:analysis*; D007150:Immunohistochemistry; D008253:Macaca mulatta / Q000378:metabolism*; D009474:Neurons / Q000737:chemistry*; D010053:Ovary / Q000502:physiology; D011960:Receptors, Estrogen / Q000032:analysis*; D012741:Sexual Maturation; D013045:Species Specificity
D011960:Receptors, Estrogen; D007987:Gonadotropin-Releasing Hormone