title: Mismatch repair, somatic mutations, and the origins of cancer.
abstract: This paper outlines the basic properties of a newly recognized pathway that should enable somatic cells to generate double-stranded mutations in the complete absence of cell proliferation. Recognition of the existence of this pathway provides us with the basis for a better understanding of a number of important biological phenomena and, in particular, may help us to understand the origins of cancers in unselected human populations.
authors.affiliation: School of Microbiology, La Trobe University, Melbourne, Victoria, Australia.
authors.forename: D G
authors.initials: DG
authors.lastname: MacPhee
mesh_terms: D002455:Cell Division / Q000235:genetics; D004260:DNA Repair; D004261:DNA Replication; D004269:DNA, Bacterial / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D007399:Interphase / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D009369:Neoplasms / Q000235:genetics*; D010641:Phenotype; D013997:Time Factors
chemical_list: D004269:DNA, Bacterial