Effects of KW-3902, an adenosine A1-receptor antagonist, on ascites volume in puromycin aminonucleoside (PAN)-induced nephrotic rats.
We investigated the effects of KW-3902 (8-(noradamantan-3-yl)-1,3-dipropylxanthine), a potent adenosine A1-receptor antagonist, on the nephrotic edema induced by puromycin aminonucleoside (PAN; 100 mg/kg, i.v.) in rats. The treatment with PAN decreased urine volume and urinary excretions of sodium and potassium, resulting in the ascites formation in 7 days. In rats with the nephrosis, KW-3902 (0.01-1 mg/kg/day for 3 days, p.o.) showed diuretic effects and reduced the volume of ascites, as was the case with furosemide (30 mg/kg/day) and trichlormethiazide (1 mg/kg/day). These results suggest that even in the nephrotic state, the adenosine A1-receptor antagonist can be an effective diuretic to ameliorate edema.
Kusaka
H
H
Department of Pharmacology, Kyowa Hakko Kogyo Co., Ltd., Shizuoka, Japan.
Nagashima
K
K
Karasawa
A
A
D000818:Animals; D001201:Ascites / Q000473:pathology*; D004232:Diuretics / Q000494:pharmacology / Q000627:therapeutic use*; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy / Q000473:pathology; D005665:Furosemide / Q000494:pharmacology; D008297:Male; D009401:Nephrosis / Q000139:chemically induced / Q000188:drug therapy* / Q000473:pathology; D058915:Purinergic P1 Receptor Antagonists; D011692:Puromycin Aminonucleoside; D051381:Rats; D017208:Rats, Wistar; D049993:Sodium Chloride Symporter Inhibitors / Q000494:pharmacology; D014237:Trichlormethiazide / Q000494:pharmacology; D014970:Xanthines / Q000627:therapeutic use*
D004232:Diuretics; D058915:Purinergic P1 Receptor Antagonists; D049993:Sodium Chloride Symporter Inhibitors; D014970:Xanthines; D011692:Puromycin Aminonucleoside; C073525:rolofylline; D005665:Furosemide; D014237:Trichlormethiazide