Cortisol: a tool to study aldosterone biosynthesis in rats.
Corticosterone (B) and 18-hydroxy-11-deoxycorticosterone (18OHDOC) but not 11-deoxycorticosterone (DOC) displaced cortisol (F) specifically bound to rat adrenal mitochondria. F. competitively inhibited aldosterone formation from B, 18OHB and 18OHDOC but did not inhibit conversions of DOC to B or 18OHDOC. High concentrations of DOC increased its conversion to 18OHDOC rather than B.
Matković
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Departamento de Química Biológica, Facultad de Cs. Exactas y Naturales-UBA and PRHOM-CONICET, Buenos Aires, Argentina.
Gomez-Sanchez
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CE
Lantos
C P
CP
Cozza
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EN
D015070:18-Hydroxydesoxycorticosterone / Q000378:metabolism*; D000311:Adrenal Glands / Q000378:metabolism* / Q000648:ultrastructure; D000450:Aldosterone / Q000096:biosynthesis*; D000818:Animals; D001667:Binding, Competitive; D003345:Corticosterone / Q000378:metabolism*; D006854:Hydrocortisone / Q000378:metabolism; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D051381:Rats; D011919:Rats, Inbred Strains
D015070:18-Hydroxydesoxycorticosterone; D000450:Aldosterone; D003345:Corticosterone; D006854:Hydrocortisone