Oculogyric crisis induced by carbamazepine.
A 32-year-old man with mental retardation and uncontrolled complex partial epilepsy receiving carbamazepine (CBZ) and divalproex sodium (VPA), developed frequent episodes of forced upward gaze after increase in the daily VPA dosage. CBZ dosage was decreased, with prompt resolution of symptoms. The upward gaze problem recurred several months later. CBZ dosage was decreased further with subsequent resolution of symptoms. Therefore, the oculogyric crisis (OGC) appeared to be induced by CBZ.
Gorman
M
M
Department of Neurology, Henry Ford Hospital, Detroit, Michigan 48202, USA.
Barkley
G L
GL
D000328:Adult; D002220:Carbamazepine / Q000009:adverse effects* / Q000097:blood / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D017029:Epilepsy, Complex Partial / Q000188:drug therapy*; D005403:Fixation, Ocular / Q000187:drug effects*; D006801:Humans; D008297:Male; D015835:Ocular Motility Disorders / Q000139:chemically induced*; D014635:Valproic Acid / Q000097:blood / Q000627:therapeutic use
D002220:Carbamazepine; D014635:Valproic Acid