Developmental toxicity of the substituted phenylurea herbicide isoproturon in rats.
Isoproturon, a substituted phenylurea herbicide, was studied for its toxicity to dams and its potential fetotoxic/teratogenic effects in the fetuses of albino rats. Isoproturon technical administered orally at 45, 90 or 180 mg/kg/d to dams during d 6-20 of pregnancy did not produce maternal toxicity at 45 or 90 mg/kg/d. However, 180 mg isoproturon/kg/d caused changes in maternal enzymes and chromatid breaks. There was no fetotoxic/teratogenic effect of isoproturon at the tested dosage levels in number of implantations, percent resorption, fetal weights, and external, visceral and skeletal fetal observations.
Srivastava
M K
MK
Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Raizada
R B
RB
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000196:embryology / Q000473:pathology; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D004798:Enzymes / Q000378:metabolism; D005260:Female; D006540:Herbicides / Q000633:toxicity*; D007668:Kidney / Q000187:drug effects / Q000473:pathology; D008099:Liver / Q000187:drug effects / Q000196:embryology / Q000201:enzymology / Q000473:pathology; D008297:Male; D008782:Methylurea Compounds / Q000633:toxicity*; D010671:Phenylurea Compounds; D011247:Pregnancy; D011374:Progesterone / Q000097:blood; D011863:Radioimmunoassay; D051381:Rats; D017208:Rats, Wistar; D012854:Sister Chromatid Exchange / Q000187:drug effects; D013723:Teratogens / Q000633:toxicity*
D004798:Enzymes; D006540:Herbicides; D008782:Methylurea Compounds; D010671:Phenylurea Compounds; D013723:Teratogens; D011374:Progesterone; C028904:isoproturon