title: [Transient dysfibrinogenemia and thrombocytopenia associated with recurrent acute pancreatitis in the course of isotretinoin therapy].
abstract: A 17 year-old young man developed two episodes of acute pancreatitis, separated by a 2 year interval and associated with isotretinoin therapy. In 1989, vesicular sludge without lithiasis was evidenced and in 1991, gall bladder stones were found by cholecystectomy. Concomitantly, transient dysfibrinogenemia and thrombopenia were present. It is interesting to note that far away from the use of isotretinoin, the patient suffered from another episode of acute pancreatitis without any coagulation disorder. The involvement of Roaccutane in cellular differentiation is discussed as well as its causal association with acquired dysfibrinogenemia and transient thrombocytopenia.
authors.affiliation: Laboratoire d'hémostase, hôpital Jean-Verdier, Bondy, France.
authors.forename: M H
authors.initials: MH
authors.lastname: Aurousseau
authors.forename: S
authors.initials: S
authors.lastname: Levacher
authors.forename: C
authors.initials: C
authors.lastname: Bénéton
authors.forename: M
authors.initials: M
authors.lastname: Blaise
authors.forename: J L
authors.initials: JL
authors.lastname: Pourriat
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D015241:Fibrinogens, Abnormal / Q000032:analysis*; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects* / Q000627:therapeutic use; D007641:Keratolytic Agents / Q000009:adverse effects / Q000627:therapeutic use; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced*; D012008:Recurrence; D013921:Thrombocytopenia / Q000139:chemically induced*
chemical_list: D015241:Fibrinogens, Abnormal; D007641:Keratolytic Agents; D015474:Isotretinoin
vernacular_title: Dysfibrinogénémie et thrombocytopénie transitoires associées à une pancréatite aiguë récidivante lors d'un traitement par l'siotrétinoïne.