title: Changes in the fatty acid profile of plasma and adipose tissue in rats after long-term ethanol feeding.
abstract: The effect of chronic ethanol feeding on the fatty acid composition of plasma and abdominal adipose tissue in rats was studied. Animals were maintained on a 30% ethanol solution in drinking water for 3 and 5 months. Control rats were given water. Caloric intake was similar in control and ethanol-fed rats at the end of the experimental period. However, a decrease in body weight was observed in rats that had consumed ethanol. Palmitoleic (16:1n7) and oleic (18:1n9) acids increased markedly, and linoleic acid (18:2n6) decreased in the plasma and in the adipose tissue of ethanol-fed rats with respect to control rats. After 3 months of ethanol ingestion, long-chain polyunsaturated fatty acids were reduced both in plasma and adipose tissue. When ethanol was administered for 5 months, only plasma long-chain polyunsaturated fatty acids of the n-3 series were decreased. This suggest that changes induced by ethanol ingestion in essential fatty acid metabolism is less pronounced when ethanol feeding is maintained for a long period of time.
authors.affiliation: Department of Physiology and Animal Biology, Facultad de Farmacia, Universidad de Sevilla, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Gómez-Tubío
authors.forename: M L
authors.initials: ML
authors.lastname: Pita
authors.forename: E
authors.initials: E
authors.lastname: Tavares
authors.forename: M L
authors.initials: ML
authors.lastname: Murillo
authors.forename: M J
authors.initials: MJ
authors.lastname: Delgado
authors.forename: O
authors.initials: O
authors.lastname: Carreras
mesh_terms: D000273:Adipose Tissue / Q000378:metabolism*; D000437:Alcoholism / Q000097:blood*; D000818:Animals; D001823:Body Composition / Q000187:drug effects*; D002149:Energy Intake / Q000502:physiology; D000431:Ethanol / Q000633:toxicity; D005227:Fatty Acids / Q000097:blood*; D005228:Fatty Acids, Essential / Q000097:blood; D015525:Fatty Acids, Omega-3 / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D005227:Fatty Acids; D005228:Fatty Acids, Essential; D015525:Fatty Acids, Omega-3; D000431:Ethanol