title: [Severe neuropathy after chemo- and radiotherapy of Ewing sarcoma].
abstract: A 15 year old patient presenting with a lumbar Ewing's Sarcoma was treated according to the EICESS-92 pilot study (EVAIA branch). Local therapy consisted of definitive irradiation given simultaneously to chemotherapy courses 5 to 7. Close to the end of treatment the patient developed progressive peripheral neurologic deficits. Such combined toxic treatment side effects are unique and unforeseen in the study protocol.
authors.affiliation: Universitäts-Kinderklinik Freiburg.
authors.forename: C
authors.initials: C
authors.lastname: Lilje
authors.forename: S
authors.initials: S
authors.lastname: Sauter
authors.forename: W
authors.initials: W
authors.lastname: Hinkelbein
authors.forename: R
authors.initials: R
authors.lastname: Korinthenberg
authors.forename: C
authors.initials: C
authors.lastname: Niemeyer
mesh_terms: D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects* / Q000627:therapeutic use; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D006801:Humans; D008159:Lumbar Vertebrae / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D009460:Neurologic Examination / Q000187:drug effects / Q000528:radiation effects; D010525:Peripheral Nerves / Q000528:radiation effects*; D010523:Peripheral Nervous System Diseases / Q000139:chemically induced*; D010865:Pilot Projects; D011832:Radiation Injuries / Q000209:etiology*; D011879:Radiotherapy Dosage; D012512:Sarcoma, Ewing / Q000188:drug therapy* / Q000532:radiotherapy*; D013125:Spinal Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*
vernacular_title: Schwere Neuropathie nach Chemo- und Radiotherapie eines Ewing-Sarkoms.