Genetic susceptibility to herpetic encephalitis of inbred rabbits of B/Jas strain.
Inbred rabbits of B/Jas strain were found to be highly susceptible to herpes simplex virus type 1 encephalitis, following i.v. injection of the virus, while Chbb:HM strain rabbits were not susceptible. The susceptibility trait seemed to be inherited recessively, involving multiple genes, because (B/Jas x Chbb:HM)F1 hybrids were as resistant as Chbb:HM rabbits, and because more than 90% of backcrosses of (B/Jas x Chbb:HM)F1 to B/Jas were resistant to viral inoculation. The encephalitis in B/Jas rabbits resembled human herpes simplex encephalitis, in that the temporal lobe as well as the brain stem were affected preferentially, leading to the development of various types of seizures, such as circling, loss of balance leading to a fall, and tonic and clonic convulsions. The disease could be diagnosed by magnetic resonance imaging (MRI) analysis before onset of seizures, and diseased rabbits showed a marked lymphopenia at onset of seizures.
Seto
A
A
Department of Microbiology, Faculty of Medicine, Shiga University of Medical Science, Japan.
Morikawa
S
S
Isono
T
T
Ogawa
K
K
Inubushi
T
T
D000818:Animals; D001921:Brain / Q000473:pathology; D002522:Chlorocebus aethiops; D003433:Crosses, Genetic; D018792:Encephalitis, Viral / Q000276:immunology* / Q000473:pathology; D020022:Genetic Predisposition to Disease; D006561:Herpes Simplex / Q000276:immunology* / Q000473:pathology; D018259:Herpesvirus 1, Human; D006801:Humans; D008279:Magnetic Resonance Imaging; D011817:Rabbits; D013045:Species Specificity; D014709:Vero Cells