Lipid peroxidation in lung of rat stressed by immobilization: effects of vitamin E supplementation.
This study was carried out to examine the possibility of initiation of lipid peroxidation in the lung of Wistar albino male rats stressed by immobilization. The effects of vitamin E supplementation were also investigated. We found that immobilization of rats with normal pulmonary content of vitamin E caused lipid peroxidation in the lung. Decrease of the lung content of unsaturated fatty acids and vitamin E was also established. The immobilization-induced changes of all of these parameters were significantly inhibited by vitamin E injection (100 mg/kg body weight) for 7 days. A possible sequence of events leading to the initiation of lipid peroxidation and lung cell membrane damage in rats stressed by immobilization is discussed.
Kovacheva
S
S
Sofia University School of Medicine, Department of Biophysics, Bulgaria.
Ribarov
S R
SR
D000818:Animals; D001143:Arousal / Q000187:drug effects / Q000502:physiology*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D007103:Immobilization / Q000502:physiology*; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology*; D008168:Lung / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000503:physiopathology*; D014810:Vitamin E / Q000378:metabolism / Q000494:pharmacology*
D005231:Fatty Acids, Unsaturated; D014810:Vitamin E