title: The MHC class I homolog encoded by human cytomegalovirus binds endogenous peptides.
abstract: The ability of a human cytomegalovirus-encoded homolog of MHC class I molecules to serve as a peptide receptor was investigated. Sequencing of peptide material eluted from the purified viral protein revealed a mixture of endogenous peptides with characteristics similar to those eluted from conventional class I molecules, that is, anchor residues, and a predominance of short peptides derived from cytoplasmic proteins. The possible function(s) of this viral MHC homolog are discussed in light of the finding that it binds endogenous peptides.
authors.affiliation: Division of Biology, California Institute of Technology, Pasadena 91125, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Fahnestock
authors.forename: J L
authors.initials: JL
authors.lastname: Johnson
authors.forename: R M
authors.initials: RM
authors.lastname: Feldman
authors.forename: J M
authors.initials: JM
authors.lastname: Neveu
authors.forename: W S
authors.initials: WS
authors.lastname: Lane
authors.forename: P J
authors.initials: PJ
authors.lastname: Bjorkman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D016466:CHO Cells; D002478:Cells, Cultured; D006224:Cricetinae; D003587:Cytomegalovirus / Q000737:chemistry*; D015395:Histocompatibility Antigens Class I / Q000737:chemistry* / Q000502:physiology*; D006801:Humans; D008958:Models, Molecular; D008969:Molecular Sequence Data; D011485:Protein Binding / Q000502:physiology; D014162:Transfection; D014764:Viral Proteins / Q000737:chemistry* / Q000502:physiology*
chemical_list: D015395:Histocompatibility Antigens Class I; D014764:Viral Proteins