Ketorolac-induced postoperative acute renal failure: a case report.
The nephrotoxic effects of nonsteroidal anti-inflammatory drugs (NSAIDs) are well recognized. Known potentiating risk factors include pre-existing renal disease, intravascular volume depletion, and concomitant administration of other nephrotoxic drugs. We present a case report of renal failure following short term usage of intramuscular ketorolac (Toradol) in a patient with no known risk factors who underwent an uncomplicated laparotomy. The literature concerning ketorolac-induced renal failure is reviewed and physicians are reminded to be aware of this potential complication.
Patel
N Y
NY
Department of Surgery, Gundersen Clinic, La Crosse, WI 54601, USA.
Landercasper
J
J
D058186:Acute Kidney Injury / Q000139:chemically induced*; D018712:Analgesics, Non-Narcotic / Q000008:administration & dosage / Q000009:adverse effects*; D018662:Fundoplication; D005764:Gastroesophageal Reflux / Q000601:surgery; D006801:Humans; D007273:Injections, Intramuscular; D007476:Ionophores; D020911:Ketorolac Tromethamine; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000139:chemically induced*; D014046:Tolmetin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives*; D014325:Tromethamine / Q000009:adverse effects / Q000031:analogs & derivatives*
D018712:Analgesics, Non-Narcotic; D007476:Ionophores; D014325:Tromethamine; D020911:Ketorolac Tromethamine; D014046:Tolmetin