title: Effect of extended ibuprofen administration on the acute phase protein response in colorectal cancer patients.
abstract: The regulation of acute phase protein production and the relationship of the acute phase protein response to tumour growth was examined in colorectal cancer patients (n = 9). Ibuprofen (1200 mg/d) was administered for 8-11 days. Following ibuprofen administration there were reductions in circulating concentrations of C-reactive protein (P = 0.01), interleukin-6 (P = 0.06), cortisol (P = 0.04) and also in the platelet count (P = 0.01). There was no significant change in albumin, insulin and carcinoembryonic antigen. These results indicate that ibuprofen administered over a prolonged period substantially reduces acute protein production via its effect on interleukin-6 and cortisol. It remains to be determined whether ibuprofen is useful in moderating tumour growth in colorectal cancer patients.
authors.affiliation: University Department of Surgery, Royal Infirmary, Glasgow, UK.
authors.forename: D C
authors.initials: DC
authors.lastname: McMillan
authors.forename: E
authors.initials: E
authors.lastname: Leen
authors.forename: J
authors.initials: J
authors.lastname: Smith
authors.forename: C
authors.initials: C
authors.lastname: Sturgeon
authors.forename: T
authors.initials: T
authors.lastname: Preston
authors.forename: T G
authors.initials: TG
authors.lastname: Cooke
authors.forename: C S
authors.initials: CS
authors.lastname: McArdle
mesh_terms: D000209:Acute-Phase Proteins / Q000187:drug effects*; D000328:Adult; D000368:Aged; D002097:C-Reactive Protein / Q000378:metabolism; D002272:Carcinoembryonic Antigen / Q000097:blood; D015179:Colorectal Neoplasms / Q000188:drug therapy* / Q000378:metabolism*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007052:Ibuprofen / Q000008:administration & dosage / Q000494:pharmacology*; D007328:Insulin / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D012709:Serum Albumin / Q000378:metabolism
chemical_list: D000209:Acute-Phase Proteins; D002272:Carcinoembryonic Antigen; D007328:Insulin; D015850:Interleukin-6; D012709:Serum Albumin; D002097:C-Reactive Protein; D006854:Hydrocortisone; D007052:Ibuprofen