title: Effects of propofol and thiopentone on picrotoxin convulsive threshold in the rabbit.
abstract: The purpose of the present study was to examine the effect of intravenous administration of propofol and thiopentone on picrotoxin-induced seizures using the picrotoxin convulsive threshold test in the rabbit. Neither propofol nor thiopentone at a dose of 1.25 mg/kg had any significant effect on picrotoxin seizure threshold. However, at higher doses (2.5, 5, 10 mg/kg) both propofol and thiopentone produced a significant and dose-dependent increase in the picrotoxin convulsive threshold. These findings suggest that propofol is an effective anticonvulsant against picrotoxin-induced seizures in the rabbit.
authors.affiliation: Department of Physiology, School of Medicine, Jordan University of Science and Technology, Irbid.
authors.forename: Z
authors.initials: Z
authors.lastname: Hasan
authors.forename: S
authors.initials: S
authors.lastname: Khatib
authors.forename: A
authors.initials: A
authors.lastname: Abu-Laban
mesh_terms: D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D008297:Male; D010852:Picrotoxin / Q000494:pharmacology*; D015742:Propofol / Q000494:pharmacology*; D011817:Rabbits; D012640:Seizures / Q000139:chemically induced; D013874:Thiopental / Q000494:pharmacology*
chemical_list: D000927:Anticonvulsants; D010852:Picrotoxin; D015742:Propofol; D013874:Thiopental