[Influence] of enzymatic treatment on Junin virus--Vero cells interaction].
The chemical nature of cellular structures involved in the attachment of Junin virus (wild type XJC13 and host range mutant Cl 67) to Vero cells was investigated. Enzyme treatment of cells before virus infection indicated that whereas lipids are not directly involved in virus attachment, cellular proteins play a significant role in early interaction with JV. Moreover aromatic residues, leucine and basic amino acid seem to actively participate in this interaction with different affinity for the assayed strains.
Raiger Iustman
L J
LJ
Depto. de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Argentina.
Candurra
N
N
Mersich
S E
SE
D000818:Animals; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D004798:Enzymes / Q000494:pharmacology*; D005260:Female; D018051:Junin virus / Q000187:drug effects* / Q000502:physiology; D008297:Male; D014709:Vero Cells / Q000187:drug effects* / Q000502:physiology / Q000821:virology
D004798:Enzymes
Influencia del tratamiento enzimático sobre la interacción virus Junín-células Vero.