title: Physiologically based pharmacokinetic and pharmacodynamic modeling in health risk assessment and characterization of hazardous substances.
abstract: Recent advances in physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) modeling have introduced novel approaches for evaluating toxicological problems. Because PBPK models are amenable to extrapolation of tissue dosimetry, they are increasingly being applied to chemical risk assessment. A comprehensive listing of PBPK/PD models for environmental chemicals developed to date is referenced. Salient applications of PBPK/PD modeling to health risk assessments and characterization of hazardous substances are illustrated with examples.
authors.affiliation: Union Carbide Corporation, Danbury, CT 06817, USA.
authors.forename: H W
authors.initials: HW
authors.lastname: Leung
authors.forename: D J
authors.initials: DJ
authors.lastname: Paustenbach
mesh_terms: D000818:Animals; D015386:Hazardous Substances / Q000493:pharmacokinetics* / Q000633:toxicity*; D006801:Humans; D008956:Models, Chemical; D011634:Public Health; D018570:Risk Assessment
chemical_list: D015386:Hazardous Substances