Assessment of effects of intravenous dipyridamole on regional myocardial perfusion in children with Kawasaki disease without angiographic evidence of coronary stenosis using positron emission tomography and H2(15)O.
BACKGROUND
Positron emission tomography and H2(15)O were used to characterize regional myocardial blood flow and distribution at rest and in response to dipyridamole in children with Kawasaki disease but without angiographic evidence of coronary stenosis.


METHODS
Patients were classified into two groups on the basis of the results of selective coronary angiography: subjects in group I had normal coronary angiograms (n = 4): subjects in group II had aneurysms (n = 5).


RESULTS
Myocardial perfusion, assessed with H2(15)O, was homogeneous over all regions at rest and at peak flow in groups I and II. Dipyridamole infusion significantly reduced myocardial perfusion reserve in group II (average 3.56 +/- 1.03 fold versus 5.06 +/- 1.37 fold in group I, P < 0.001).


CONCLUSIONS
Our results suggest that aneurysms associated with Kawasaki disease may reduce myocardial reserve. Non-invasive quantitative assessment of myocardial blood flow with positron emission tomography and H2(15)O was useful in assessing the functional capacity of coronary artery lesions and the extent of myocardial damage in children with Kawasaki disease.
Ohmochi
Y
Y
Division of Pediatrics, Children's Research Hospital, Kyoto Prefectural University of Medicine, Japan.
Onouchi
Z
Z
Oda
Y
Y
Hamaoka
K
K
D000293:Adolescent; D000328:Adult; D003323:Coronary Aneurysm / Q000000981:diagnostic imaging / Q000503:physiopathology; D017023:Coronary Angiography; D003326:Coronary Circulation / Q000187:drug effects*; D004176:Dipyridamole / Q000008:administration & dosage / Q000494:pharmacology; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000000981:diagnostic imaging* / Q000503:physiopathology; D010104:Oxygen Radioisotopes; D014055:Tomography, Emission-Computed / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D014867:Water
D010104:Oxygen Radioisotopes; D014867:Water; D004176:Dipyridamole