title: [Physical training exercise reduces the plasma levels of fibrinogen in subjects with mild hypertension].
abstract: We evaluated the behaviour of plasma fibrinogen in subjects undergoing physical training in a prospective non-controlled open study, carried out in 14 sedentary, mildly hypertensive individuals (mean age 52 +/- 5 years). Subjects underwent 3 months of controlled physical training (3 times a week) tailored to reach, at each session, 80-90% of maximal heart rate based upon a baseline test. Before and after the period of training, resting systolic and diastolic blood pressure, 24-hour systolic and diastolic blood pressure, plasma fibrinogen, body mass index (BMI), maximum oxygen consumption (VO2max), serum cholesterol and triglycerides were evaluated. After training VO2 max increased (24 +/- 5 vs 30 +/- 5 mL/Kg/min, p < 0.01); there were no variations in BMI (24 +/- 2 vs 23 +/- 2 Kg/m2, p = 0.35), cholesterol (220 +/- 30 vs 213 +/- 36 mg/dL, p = 0.41) or triglycerides (117 +/- 51 vs 118 +/- 37 mg/dL, p = 0.58). Resting systolic (148 +/- 10 vs 133 +/- 10 mmHg, p < 0.01) and diastolic blood pressure (97 +/- 5 vs 85 +/- 6 mmHg, p < 0.01) and 24-hour systolic (135 +/- 6 vs 129 +/- 5 mmHg, p < 0.01) and diastolic blood pressure (86 +/- 7 vs 81 +/- 6 mmHg, p < 0.01) decreased; plasma fibrinogen also decreased (324 +/- 60 vs 278 +/- 53 mg/dL, p < 0.01). Eight individuals tested 5 months after cessation of training, showed a return of fibrinogen, blood pressure and VO2 max to baseline values.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Centro Emofilia e Trombosi, Angelo Bianchi Bonomi, IRCCS Ospedale Maggiore Policlinico, Università degli Studi di Milano.
authors.forename: D
authors.initials: D
authors.lastname: Bettega
authors.forename: R
authors.initials: R
authors.lastname: Zanettini
authors.forename: M
authors.initials: M
authors.lastname: Ferretti
mesh_terms: D001794:Blood Pressure; D018660:Blood Pressure Monitoring, Ambulatory; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test; D005260:Female; D005340:Fibrinogen / Q000032:analysis*; D006801:Humans; D006973:Hypertension / Q000097:blood* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D005340:Fibrinogen
vernacular_title: L'esercizio fisico allenante riduce i livelli plasmatici di fibrinogeno in soggetti con ipertensione lieve.