title: [Primary and experimental study of a new treatment for hepatolithiasis by injection of resin in the intrahepatic bile duct].
abstract: In the treatment of hepatolithiasis, it is sometimes difficult to remove the stones completely and residual stones are closely related to the prognosis. In cases with residual stones, cholangitis frequently recurs and sometimes it causes fatal hepatic failure. We postulated that filling the hepatic bile duct with resin may be useful for the prevention of the progress of this disease. This experiment is the preliminary study on this new treatment for hepatolithiasis. After the injection of Neoprene resin into the left intrahepatic bile duct of a mongrel dog, histological changes of the liver and biochemical changes in peripheral blood were serially analyzed. After six months, the Neoprene plug remained in place. In the lobe treated with Neoprene, volume and weight decreased, and fibrosis around the bile duct and interlobular connective tissue increased, while, the number of hepatocytes was not changed. There was neither abscess nor biloma in the liver. Blood analysis revealed only a transitional increase of GOT, GPT and ALP. No complication was caused by this treatment. From this result, we conclude that this new method may be useful for the treatment of hepatolithiasis.
authors.affiliation: First Department of Surgery, Kobe University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ohara
authors.forename: H
authors.initials: H
authors.lastname: Onoyama
authors.forename: M
authors.initials: M
authors.lastname: Tomita
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
mesh_terms: D000818:Animals; D001653:Bile Ducts, Intrahepatic; D002137:Calculi / Q000473:pathology / Q000628:therapy*; D004285:Dogs; D004621:Embolization, Therapeutic; D007267:Injections / Q000379:methods; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology / Q000628:therapy*; D008111:Liver Function Tests; D009387:Neoprene / Q000008:administration & dosage*; D012116:Resins, Plant / Q000008:administration & dosage*
chemical_list: D012116:Resins, Plant; D009387:Neoprene