title: [14C-urea breath test in the diagnosis of Helicobacter pylori infection in the stomach].
abstract: We developed a modified 14C-urea breath test (14C-UBT) to diagnose Helicobacter pylori (Hp) infection in 70 patients in which subjects were given 92.5 kBq (2.5 microCi) 14C-urea with 25 mg nonradioactive urea, without nutrient-dense meal. Using the mean value +3s as a cutoff value, the 20 min sample gave a sensitivity of 97.36%, a specificity of 90.00%, a positive predictive value of 97.36%, and a negative predictive value of 90.0%. Our data showed: (1) A satisfying accuracy of the modified 14C-UBT for the detection of Hp infection was obtained. (2) Taking 92.5 kBq (2.5 microCi) 14C-urea and 20 min collected sample may be of great use and to replace the previous big dose and long time methods. (3) This test may be applied routinely as a noninvasive, accurate, low cost, safe and rapid method. (4) It played an important role in reflecting the susceptibility of Hp to various drugs in vivo and monitoring the recurence of Hp.
authors.affiliation: Department of Gastroenterology, Southwest Hospital, 3rd Military Medical University, Chongqing.
authors.forename: C
authors.initials: C
authors.lastname: Xu
authors.forename: H
authors.initials: H
authors.lastname: Xu
authors.forename: S
authors.initials: S
authors.lastname: Cheng
mesh_terms: D000328:Adult; D001944:Breath Tests; D002250:Carbon Radioisotopes; D005260:Female; D005756:Gastritis / Q000175:diagnosis*; D016481:Helicobacter Infections / Q000175:diagnosis*; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000175:diagnosis; D013997:Time Factors; D014508:Urea
chemical_list: D002250:Carbon Radioisotopes; D014508:Urea