title: Suprapubic cystotomy as treatment for severe hemorrhagic cystitis after bone marrow transplantation.
abstract: We analyzed the success of suprapubic cystotomy in patients with severe hemorrhagic cystitis after bone marrow transplantation. Seventy-three out of 963 patients developed severe hemorrhagic cystitis which resulted in urinary tract obstruction after high-dose cytoreductive therapy. Eleven patients (15%) failed medical treatment and required emergency suprapubic cystotomy. Three of these patients died of other complications prior to resolution of HC. Of the remaining 8 patients who underwent surgery, 4 are alive. The mortality rate was significantly higher in patients who required surgery than in those who responded to medical therapy. Patients whose HC required surgery also had a greater transfusion requirement than those who responded to medical therapy. We conclude that surgical treatment of severe HC should be undertaken only after failure of medical therapy.
authors.affiliation: Divisione Ematologica e Centro Trapianto di Midollo Osseo di Muraglia, Pesaro, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Baronciani
authors.forename: E
authors.initials: E
authors.lastname: Angelucci
authors.forename: B
authors.initials: B
authors.lastname: Erer
authors.forename: G
authors.initials: G
authors.lastname: Fabrizi
authors.forename: M
authors.initials: M
authors.lastname: Galimberti
authors.forename: C
authors.initials: C
authors.lastname: Giardini
authors.forename: D
authors.initials: D
authors.lastname: Milella
authors.forename: M
authors.initials: M
authors.lastname: Montesi
authors.forename: P
authors.initials: P
authors.lastname: Polchi
authors.forename: A
authors.initials: A
authors.lastname: Severini
mesh_terms: D000293:Adolescent; D000328:Adult; D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D003556:Cystitis / Q000601:surgery*; D003559:Cystostomy; D005260:Female; D006470:Hemorrhage / Q000601:surgery*; D006801:Humans; D007223:Infant; D008297:Male; D008875:Middle Aged