title: Toxic and neurogenic factors in chloroquine myopathy fibre selectivity.
abstract: Biopsies from soleus and extensor digitorum longus (EDL) muscles obtained in rats with an experimental chloroquine myopathy were studied ultrastructurally. Two different histopathological pictures were observed: type I fibres from soleus exhibited a vacuolar myopathy with an almost normal sarcomeric structure; type II fibres from EDL did not show vacuoles but changes similar to neurogenic atrophy. Our results suggest that chloroquine produces direct toxic effects in type I fibres and secondary neurogenic damage in type II fibres.
authors.affiliation: Department of Histology and Embryology, Faculty of Medicine, Caracas, Venezuela.
authors.forename: E
authors.initials: E
authors.lastname: Velasco
authors.forename: H J
authors.initials: HJ
authors.lastname: Finol
authors.forename: A
authors.initials: A
authors.lastname: Marquez
mesh_terms: D000818:Animals; D002738:Chloroquine / Q000633:toxicity*; D008297:Male; D008854:Microscopy, Electron; D018656:Muscle Fibers, Fast-Twitch / Q000187:drug effects / Q000648:ultrastructure*; D018657:Muscle Fibers, Slow-Twitch / Q000187:drug effects / Q000648:ultrastructure*; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology / Q000648:ultrastructure*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002738:Chloroquine