Interleukin-10 and its receptor.
The cytokine interleukin-10 (IL-10) has several important activities on cells of the immune system. IL-10 profoundly suppresses activation of macrophages, inhibiting their ability to secrete cytokines and serve as accessory cells for stimulation of T cell and natural killer (NK) cell function. IL-10 also plays a role in stimulating proliferation and differentiation of B cells, mast cells, and both mature and immature T cells. At least two herpesviruses harbor analogs of the IL-10 gene; the Epstein-Barr virus (EBV) homolog (BCRF1, viral IL-10, vIL-10) shares several of the cellular cytokine's activities, one or all of which may be important in the host-virus relationship. This article reviews recent studies on the function of IL-10 and discusses the initial characterization of its receptor.
Ho
A S
AS
Department of Immunology, DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, CA 94306, USA.
Moore
K W
KW
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D015551:Autoimmunity / Q000276:immunology; D001402:B-Lymphocytes / Q000166:cytology; D002454:Cell Differentiation; D005796:Genes; D005814:Genes, Viral; D006410:Hematopoiesis; D004854:Herpesvirus 4, Human / Q000254:growth & development; D006801:Humans; D007108:Immune Tolerance; D007249:Inflammation / Q000276:immunology; D016753:Interleukin-10 / Q000502:physiology*; D008213:Lymphocyte Activation; D008262:Macrophage Activation; D008264:Macrophages / Q000276:immunology; D018123:Receptors, Interleukin / Q000502:physiology*; D053701:Receptors, Interleukin-10; D013601:T-Lymphocytes / Q000276:immunology; D018417:Th1 Cells / Q000276:immunology; D018418:Th2 Cells / Q000276:immunology; D015678:Viral Structural Proteins / Q000235:genetics
D018123:Receptors, Interleukin; D053701:Receptors, Interleukin-10; D015678:Viral Structural Proteins; D016753:Interleukin-10