Levels of interleukin 6 and tumor necrosis factor in serum from humans vaccinated with live, attenuated Francisella tularensis.
The levels of interleukin 6 (IL-6) and tumor necrosis factor alpha in serum did not change significantly during the course of immunization with the live vaccine strain of Francisella tularensis. Higher levels of circulating IL-6 were found in the sera of vaccinees with good antibody responses than in the sera from nonresponders. Preimmunization levels of IL-6 in serum were also higher in responders than in nonresponders.
Krakauer
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Applied Research Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA.
D000328:Adult; D001428:Bacterial Vaccines / Q000276:immunology*; D005604:Francisella tularensis / Q000276:immunology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D014613:Vaccines, Attenuated / Q000276:immunology*
D001428:Bacterial Vaccines; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D014613:Vaccines, Attenuated