Myocardial ischemia after cardiopulmonary bypass.
Intraoperatively, myocardial ischemia is more common after cardiopulmonary bypass (CPB) than before CPB. Ischemia associated with coronary vasospasm and thrombosis may be much more common toward the end of surgery and early in the postoperative period than previously appreciated. This may be because the coagulation system is altered during CPB, and the coronary endothelium is damaged significantly as a result of cardioplegic arrest followed by reperfusion. In this milieu, vasospasm and thrombosis may be caused by the administration of protamine. Some of the ischemia observed in this period actually is not reversible and is associated with myocardial injury and infarction. It may be ameliorated by the administration of calcium channel blockers, aspirin, and anticoagulants. Electrocardiography may be the most suitable modality for the detection of ischemia after CPB and postoperatively. During this period, many episodes of ST deviation are of a nonischemic etiology, and the ECG needs careful interpretation. Transesophageal echocardiography is suitable for use intraoperatively and early on in the intensive care unit.
Jain
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Department of Anesthesia, University of California, San Francisco, USA.
D002315:Cardiopulmonary Bypass; D006801:Humans; D009200:Myocardial Contraction; D017202:Myocardial Ischemia / Q000209:etiology* / Q000503:physiopathology*; D011183:Postoperative Complications; D011479:Protamines / Q000494:pharmacology; D014661:Vasoconstriction / Q000187:drug effects
D011479:Protamines