Genotoxicity of the herbicide butachlor in cultured human lymphocytes.
Butachlor, a pre-emergence herbicide was investigated for its ability to induce sister chromatid exchanges (SCE) and chromosome aberrations (CA) in cultured human peripheral blood lymphocytes. Mitogen-stimulated lymphocytes were treated with three different concentrations (5, 10 and 20 micrograms/ml) of butachlor for 24, 48 and 72 h. Our results indicate a dose-dependent increase in the frequency of chromosomal aberrations at 24, 48 and 72 h of treatment with butachlor. No SCE was promoted by butachlor.
Sinha
S
S
Cancer Biology Division, School of Biological Sciences, Madurai Kamaraj University, India.
Panneerselvam
N
N
Shanmugam
G
G
D000083:Acetanilides / Q000633:toxicity*; D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005260:Female; D006540:Herbicides / Q000633:toxicity*; D006801:Humans; D008214:Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009153:Mutagens / Q000633:toxicity*; D012854:Sister Chromatid Exchange
D000083:Acetanilides; D006540:Herbicides; D009153:Mutagens; C054409:butachlor