[Multifactor analysis of the action of norfloxacin on the humoral immune response].
Multifactor analysis of the norfloxacin action on the primary immune response to the bacterial antigen (EV vaccine fraction 1) and cellular antigen (sheep erythrocytes) in mice was carried out with using a wide variety of the doses and administration times. In the doses corresponding to the average therapeutic ones norfloxacin was shown to have no effect on the humoral immune response to the bacterial and cellular antigens. In the subtherapeutic doses norfloxacin increased it thus mainly stimulating the synthesis of the IgM antibodies. In the doses exceeding the therapeutic ones the antibiotic lowered the antibody content. The diverse type immunoregulatory action of norfloxacin on the content of the IgG and IGM antibodies could be useful in the rational choice of fluoroquinolones for the treatment of patients with selective deficiency of immunoglobulins of various classes.
Iordanova
A I
AI
Smolkina
T V
TV
Nikitin
A V
AV
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000937:Antigen-Antibody Reactions; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines / Q000276:immunology*; D005591:Chemical Fractionation; D004912:Erythrocytes / Q000276:immunology*; D005163:Factor Analysis, Statistical; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D051379:Mice; D008808:Mice, Inbred CBA; D009643:Norfloxacin / Q000494:pharmacology*; D012756:Sheep
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D009643:Norfloxacin
Mnogofaktornyĭ analiz deĭstviia norfloksatsina na gumoral'nyĭ immunnyĭ otvet.