title: Effect of heparin on hemagglutination by Akabane and Aino viruses belonging to the Simbu group of bunyaviruses.
abstract: Heparin inhibited the hemagglutinin activity of Akabane and Aino viruses. The minimal inhibitory concentration of heparin required to inhibit 8 hemagglutination (HA) U of Akabane and Aino viruses was 10 U/ml. Goose erythrocytes failed to combine with the HA inhibitory factor of heparin. On the other hand, goose erythrocytes treated with heparinase had greatly reduced agglutinability by Akabane virus. Virus-heparin complex formation was observed by sedimenting heparin with the virus particles.
authors.affiliation: Department of Veterinary Epizootiology, College of Agriculture and Veterinary Medicine, Nihon University, Kanagawa, Japan.
authors.forename: E R
authors.initials: ER
authors.lastname: Jusa
authors.forename: Y
authors.initials: Y
authors.lastname: Inaba
authors.forename: K
authors.initials: K
authors.lastname: Ishibashi
authors.forename: M
authors.initials: M
authors.lastname: Noda
mesh_terms: D000818:Animals; D000925:Anticoagulants / Q000494:pharmacology*; D002043:Bunyaviridae / Q000187:drug effects* / Q000502:physiology; D002498:Centrifugation; D005777:Geese; D006387:Hemagglutination, Viral / Q000187:drug effects*; D006493:Heparin / Q000494:pharmacology*; D019763:Heparin Lyase; D051379:Mice; D011133:Polysaccharide-Lyases / Q000494:pharmacology
chemical_list: D000925:Anticoagulants; D006493:Heparin; D011133:Polysaccharide-Lyases; D019763:Heparin Lyase