title: Effect of lidocaine injection of EOAE in patients with tinnitus.
abstract: In the present study, evoked otoacoustic emissions (EOAEs) were measured in 30 patients with tinnitus before and after intravenous lidocaine injection (1 mg/kg). For EOAE recordings, 1 kHz tone burst stimuli were used. Intravenous lidocaine injection resulted in suppression of tinnitus in 22 (73%) ears, and changes of EOAE amplitude (increase or decrease) in 18 (60%) ears. Of the 18 ears with EOAE amplitude changes, tinnitus disappeared or decreased in 17 (94%) ears. In 12 ears without changes of EOAE amplitude, tinnitus was suppressed in only 5 (42%). Changes in latency were not detected in any of the ears. These results indicate that there is a relationship between the effect of lidocaine in tinnitus suppression and changes in cochlear micromechanics caused by lidocaine.
authors.affiliation: Department of Otolaryngology, Osaka Medical College, Takatsuki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Haginomori
authors.forename: K
authors.initials: K
authors.lastname: Makimoto
authors.forename: M
authors.initials: M
authors.lastname: Araki
authors.forename: M
authors.initials: M
authors.lastname: Kawakami
authors.forename: H
authors.initials: H
authors.lastname: Takahashi
mesh_terms: D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D001301:Audiometry, Pure-Tone; D001306:Auditory Pathways; D003051:Cochlea / Q000187:drug effects* / Q000502:physiology*; D007758:Ear, Inner / Q000187:drug effects* / Q000503:physiopathology*; D004525:Efferent Pathways; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000150:complications / Q000175:diagnosis; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014012:Tinnitus / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D000779:Anesthetics, Local; D008012:Lidocaine