Detection of antiribosomal P protein antibodies in patients with systemic sclerosis.
This study investigated the prevalence and clinical significance of anti-ribosomal P protein (anti-P) antibodies in patients with systemic sclerosis (SSc). Serum samples from 150 patients with SSc were examined by indirect immunofluorescence. ELISA and immunoblotting. Anti-P antibodies were detected in four (3%) patients with SSc. Three of the four patients showed SSc/SLE (systemic lupus erythematosus) overlap syndrome, but psychiatric disorders were not observed in these patients. By longitudinal immunoblotting analysis one patient, who was initially diagnosed with SSc, later developed anti-P antibodies along clinical manifestations of SLE. Our data suggest that anti-P antibodies are uncommon in SSc and that the presence of anti-P antibodies in patients with SSc indicates an overlap with SLE.
Fujimoto
M
M
Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.
Sato
S
S
Takehara
K
K
Nojima
Y
Y
Soma
Y
Y
Kikuchi
K
K
Ihn
H
H
Igarashi
A
A
Tamaki
K
K
D000328:Adult; D000888:Antibodies, Anti-Idiotypic / Q000097:blood*; D005260:Female; D006801:Humans; D008137:Longitudinal Studies; D008180:Lupus Erythematosus, Systemic / Q000276:immunology; D015800:Protozoan Proteins; D012269:Ribosomal Proteins / Q000276:immunology*; D012595:Scleroderma, Systemic / Q000097:blood / Q000276:immunology*
D000888:Antibodies, Anti-Idiotypic; C064601:L12E protein, Trypanosoma cruzi; D015800:Protozoan Proteins; D012269:Ribosomal Proteins