Efficacy of moxidectin pour-on against nematode infections in cattle.
Three groups of eight calves, naturally infected with gastrointestinal nematodes and artificially infected with Dictyocaulus viviparus were used to evaluate the efficacy of moxidectin pour-on at dose rates of 0.35 mg/kg and 0.5 mg/kg bodyweight. With both doses the efficacy was 100 per cent against adult D viviparus, Trichostrongylus axei, Ostertagia species and Nematodirus helvetianus. It was more than 99 per cent against Ostertagia and Nematodirus species fourth stage larvae. A small number of Cooperia species were found after treatment, and for this parasite, the efficacy of moxidectin ranged from 97.6 per cent against the larval stages to 98.8 per cent against the adults. No adverse reactions to the moxidectin treatment were observed.
Hubert
J
J
Station de Pathologie Aviaire et de Parasitologie, Nouzilly, France.
Kerboueuf
D
D
Le Stang
J P
JP
Cardinaud
B
B
Blond
F
F
D000018:Abomasum / Q000469:parasitology; D000287:Administration, Topical; D000821:Animal Feed / Q000469:parasitology; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents; D002417:Cattle; D002418:Cattle Diseases / Q000097:blood / Q000188:drug therapy* / Q000469:parasitology; D004022:Dictyocaulus Infections / Q000097:blood / Q000188:drug therapy; D005243:Feces / Q000469:parasitology; D007411:Intestinal Diseases, Parasitic / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D007421:Intestine, Small / Q000469:parasitology; D008168:Lung / Q000469:parasitology; D008174:Lung Diseases, Parasitic / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D018942:Macrolides / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D009348:Nematoda / Q000302:isolation & purification; D009349:Nematode Infections / Q000097:blood / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D010270:Parasite Egg Count / Q000662:veterinary; D010435:Pepsinogens / Q000097:blood; D011897:Random Allocation
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; D010435:Pepsinogens; C027837:moxidectin