title: Candidal brain abscess associated with vascular invasion: a devastating complication of vascular catheter-related candidemia.
abstract: We describe a patient who developed Candida albicans brain abscess associated with prominent vascular invasion following an episode of central venous catheter-related fungemia. The increasing population of immunosuppressed patients and the frequent use of broad-spectrum antimicrobials, corticosteroids, chemotherapeutics, organ transplantation, and prolonged supportive measures are responsible for an increasing incidence of candidal infections. Brain abscess is a rare complication of candidemia but may be expected to become more common as venous catheter-related fungemia is encountered more frequently.
authors.affiliation: Department of Clinical Epidemiology, LDS Hospital, Salt Lake City, Utah 84143, USA.
authors.forename: S J
authors.initials: SJ
authors.lastname: Burgert
authors.forename: D C
authors.initials: DC
authors.lastname: Classen
authors.forename: J P
authors.initials: JP
authors.lastname: Burke
authors.forename: D D
authors.initials: DD
authors.lastname: Blatter
mesh_terms: D000666:Amphotericin B / Q000627:therapeutic use; D001157:Arterial Occlusive Diseases / Q000175:diagnosis / Q000209:etiology; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D001922:Brain Abscess / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D002176:Candida albicans / Q000302:isolation & purification; D002177:Candidiasis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D002340:Carotid Artery Diseases / Q000175:diagnosis / Q000209:etiology; D002343:Carotid Artery, Internal / Q000473:pathology; D002405:Catheterization, Central Venous / Q000009:adverse effects*; D002536:Cerebral Arteries / Q000473:pathology; D003399:Craniotomy; D004359:Drug Therapy, Combination; D005437:Flucytosine / Q000627:therapeutic use; D016469:Fungemia / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D018810:Magnetic Resonance Angiography; D008297:Male; D008875:Middle Aged; D014057:Tomography, X-Ray Computed
chemical_list: D000666:Amphotericin B; D005437:Flucytosine