Effects of vinca alkaloids on rat parotid and submandibular glands function in vivo.
1. Vincristine (1 mg/kg) and vinblastine (2 mg/kg) were injected intraperitoneally into the rats, 24 hr before the experiments. 2. Animals were anesthetized with 50 mg/kg of sodium pentobarbital and saliva was collected from vincristine-treated, vinblastine-treated and control animals using 8 mg/kg of pilocarpine as secretagogue. 3. Parotid saliva was analyzed for protein, amylase and Ca2+ content, and submandibular saliva for flow rate, protein and Ca2+ concentration. 4. Saliva from two treated groups was significantly lower (P < 0.01) in flow rate, amylase and protein content than that of control group. Calcium level was significantly increased (P < 0.05) in treated animals. 5. It is concluded that the antisecretory effects of vinca alkaloids may be consistent with their actions on salivary cell microtubules.
Dehpour
A R
AR
Department of Pharmacology, School of Medicine, Tehran University of Medical Science, Iran.
Ghafourifar
P
P
Madani
F
F
Mousavizadeh
K
K
Abdollahi
M
M
D000681:Amylases / Q000378:metabolism; D000818:Animals; D002118:Calcium / Q000502:physiology; D008297:Male; D009929:Organ Size / Q000187:drug effects; D010306:Parotid Gland / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology*; D011506:Proteins / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012463:Saliva / Q000187:drug effects / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects; D013363:Submandibular Gland / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology*; D014747:Vinblastine / Q000494:pharmacology*; D014750:Vincristine / Q000494:pharmacology*
D011506:Proteins; D014750:Vincristine; D014747:Vinblastine; D000681:Amylases; D002118:Calcium