title: Wallaby transthyretin.
abstract: A cDNA library was constructed from liver RNA of the Australian diprotodont marsupial Macropus eugenii, the Tammar wallaby. A cloned full-length transthyretin cDNA was sequenced. The derived amino-acid sequence showed 68% overall similarity to that of human transthyretin, with 86% similarity in the thyroxine binding site. Comparisons of nucleotide and amino acid sequences from several vertebrate species indicated that the greatest differences were in the region corresponding to the disordered N-terminus of mature human transthyretin. The evolutionary trees deduced from parsimony analyses of amino acid and nucleotide sequences of transthyretins, are consistent with that derived from fossil records.
authors.affiliation: Russell Grimwade School of Biochemistry, University of Melbourne, Parkville, Australia.
authors.forename: C M
authors.initials: CM
authors.lastname: Brack
authors.forename: W
authors.initials: W
authors.lastname: Duan
authors.forename: A J
authors.initials: AJ
authors.lastname: Hulbert
authors.forename: G
authors.initials: G
authors.lastname: Schreiber
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D006801:Humans; D008099:Liver / Q000737:chemistry; D007614:Macropodidae / Q000235:genetics*; D008969:Molecular Sequence Data; D010802:Phylogeny; D011228:Prealbumin / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D012689:Sequence Homology, Nucleic Acid; D013045:Species Specificity
chemical_list: D018076:DNA, Complementary; D011228:Prealbumin