Detection of 1-phenyl-N-methyl-1,2,3,4-tetrahydroisoquinoline and 1-phenyl-1,2,3,4-tetrahydroisoquinoline in human brain by gas chromatography-tandem mass spectrometry.
1-Phenyl-N-methyl-1,2,3,4-tetrahydroisoquinoline and 1-phenyl-1,2,3,4-tetrahydroisoquinoline were detected for the first time in parkinsonian human brain using gas chromatography-tandem mass spectrometry (GC-MS-MS). Since these compounds are structural analogues of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) that produces parkinsonism in humans, they might be candidates for endogenous MPTP-like neurotoxins.
Kajita
M
M
Nagoya University Branch Hospital, Japan.
Niwa
T
T
Fujisaki
M
M
Ueki
M
M
Niimura
K
K
Sato
M
M
Egami
K
K
Naoi
M
M
Yoshida
M
M
Nagatsu
T
T
D000368:Aged; D000369:Aged, 80 and over; D001921:Brain / Q000378:metabolism*; D005260:Female; D008401:Gas Chromatography-Mass Spectrometry / Q000379:methods*; D006801:Humans; D007546:Isoquinolines / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000378:metabolism*; D044005:Tetrahydroisoquinolines
C096777:1,2,3,4-tetrahydro-N-methyl-1-phenylisoquinoline; D007546:Isoquinolines; D044005:Tetrahydroisoquinolines; C096775:1,2,3,4-tetrahydro-1-phenylisoquinoline