title: Molecular biology and clinical applications to cancer.
abstract: New insights into the genetic changes associated with cancer, the genetic control of programmed cell death, and the availability of new tools to study biologic problems including targeted gene disruption and quantitative polymerase chain reaction have defined new questions and allowed more sophisticated answers in studies of fundamental cellular processes. The development of new approaches in the clinic, including nascent gene therapies, is rapidly evolving.
authors.affiliation: Section of Surgical Oncology, University of Pittsburgh Medical Center, PA 15261, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Lotze
mesh_terms: D017209:Apoptosis / Q000235:genetics; D002869:Chromosome Aberrations; D015316:Genetic Therapy / Q000379:methods; D006801:Humans; D015847:Interleukin-4 / Q000235:genetics; D008967:Molecular Biology; D009369:Neoplasms / Q000235:genetics* / Q000628:therapy; D009386:Neoplastic Syndromes, Hereditary / Q000235:genetics / Q000628:therapy; D016133:Polymerase Chain Reaction / Q000379:methods; D014162:Transfection
chemical_list: D015847:Interleukin-4