[A new model describing the isolation of fluorocarbons from an organism: dissolution of fluorocarbons in the lipid components of blood].
Perfluorodecalin (PFD), intravenously administrated to rabbits in the form of submicron emulsion, quickly disappears from the blood stream and accumulates in the liver, spleen and bone marrow. The expiration rate of PFD from the body can be significantly enhanced by intravenous administration of sunflower oil emulsion. It is supposed that the limit stage of PFD excretion is a fluorocarbon transport from accumulatory organs to the lungs by lipid carriers (lipoproteins, chylomicrons and cell membranes) in which fluorocarbons are physically dissolved.
Obraztsov
V V
VV
Kabal'noĭ
A S
AS
Sklifas
A N
AN
Makarov
K N
KN
D000818:Animals; D001802:Blood Substitutes / Q000302:isolation & purification* / Q000493:pharmacokinetics; D001853:Bone Marrow / Q000378:metabolism; D004655:Emulsions; D005466:Fluorocarbons / Q000097:blood / Q000302:isolation & purification* / Q000493:pharmacokinetics; D008055:Lipids / Q000097:blood*; D008099:Liver / Q000378:metabolism; D008168:Lung / Q000378:metabolism; D011817:Rabbits; D012995:Solubility; D013154:Spleen / Q000378:metabolism; D014018:Tissue Distribution
D001802:Blood Substitutes; D004655:Emulsions; D005466:Fluorocarbons; D008055:Lipids; C008805:perfluorodecalin
Novaia model', opisyvaiushchaia vyvedenie ftoruglerodov iz organizma: rastvorenie ftoruglerodov v lipidnykh komponentakh krovi.