Longitudinal melanonychia induced by hydroxyurea: four case reports and review of the literature.
Although the occurrence of skin lesions during long-term hydroxyurea therapy is well known, longitudinal melanonychia (LM) are more rarely described. In the present paper, we report four cases of LM associated with skin lesions induced by long-term daily hydroxyurea therapy (4 to 10 years), characterized by two uncommon aspects: late onset (2.5 to 5 years) and predominance of toenail involvement in three cases.
Delmas-Marsalet
B
B
Service d'Hématologie, Hôpital Louis Mourier, Colombes, France.
Beaulieu
P
P
Teillet-Thiebaud
F
F
Jary
L
L
Teillet
F
F
D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D008543:Melanins / Q000096:biosynthesis*; D008875:Middle Aged; D009260:Nail Diseases / Q000139:chemically induced* / Q000378:metabolism; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000378:metabolism
D008543:Melanins; D006918:Hydroxyurea