title: Can varying flow velocity across an arterial anastomosis prevent thromboembolic injury?
abstract: In this study, simulated "poor" repairs applied to transverse incisions in the iliac arteries of 40 rats were the basis for comparing the effect of variations in blood flow on thromboembolism. Using vital microscopy and digital image processing, we performed 2 experiments. In the first experiment (n = 20), the reduction of post-repair blood flow by approximately 50% resulted in an 83% reduction in the total number of emboli appearing in the microcirculation of the cremaster muscle distal to the repair. In the second experiment (n = 20), the same reduction in blood flow typically resulted in larger repair-site thrombi which required significantly more time to grow to their maximum size. We conclude that reducing pedicle artery blood flow to approximately half in our rat model during reperfusion can protect the downstream microcirculation from embolic injury without increasing the incidence of thrombotic occlusion.
authors.affiliation: Department of Surgery, University of Louisville, KY 40292, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Barker
authors.forename: D M
authors.initials: DM
authors.lastname: Andresen
authors.forename: G L
authors.initials: GL
authors.lastname: Anderson
authors.forename: D
authors.initials: D
authors.lastname: Schuschke
authors.forename: J M
authors.initials: JM
authors.lastname: Gu
authors.forename: S
authors.initials: S
authors.lastname: Gupta
authors.forename: V E
authors.initials: VE
authors.lastname: Hjortdal
authors.forename: J W
authors.initials: JW
authors.lastname: Derr
authors.forename: J C
authors.initials: JC
authors.lastname: Banis
authors.forename: R D
authors.initials: RD
authors.lastname: Acland
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D001783:Blood Flow Velocity; D008297:Male; D008833:Microcirculation; D008866:Microsurgery; D011183:Postoperative Complications / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012039:Regional Blood Flow; D015424:Reperfusion / Q000379:methods*; D013524:Surgical Flaps / Q000502:physiology*; D013923:Thromboembolism / Q000517:prevention & control*