title: Schizophrenia and GABAA receptor subunit genes.
abstract: Alterations in gamma-aminobutyric acid (GABA) neurotransmission have been indirectly implicated in the pathogenesis of schizophrenia. Using nine multiplex pedigrees, we tested for linkage between schizophrenia and simple sequence repeat polymorphisms for the GABAA receptor alpha 1, alpha 2, alpha 4, alpha 5, alpha 6, beta 1 and beta 3 subunit genes. Evidence of linkage was not found when assuming either autosomal dominant or autosomal recessive inheritance. The non-parametric sib pair test also did not reveal significant evidence of deviation from expected segregation ratios.
authors.affiliation: University of Utah School of Medicine, Department of Psychiatry, Salt Lake City 84132, USA.
authors.forename: W
authors.initials: W
authors.lastname: Byerley
authors.forename: M E
authors.initials: ME
authors.lastname: Bailey
authors.forename: A A
authors.initials: AA
authors.lastname: Hicks
authors.forename: B P
authors.initials: BP
authors.lastname: Riley
authors.forename: M G
authors.initials: MG
authors.lastname: Darlison
authors.forename: J
authors.initials: J
authors.lastname: Holik
authors.forename: M
authors.initials: M
authors.lastname: Hoff
authors.forename: F
authors.initials: F
authors.lastname: Umar
authors.forename: F
authors.initials: F
authors.lastname: Reimherr
authors.forename: P
authors.initials: P
authors.lastname: Wender
mesh_terms: D005799:Genes, Dominant; D005808:Genes, Recessive; D006801:Humans; D008126:Lod Score; D018598:Minisatellite Repeats; D009679:Nuclear Family; D010375:Pedigree; D011963:Receptors, GABA-A / Q000235:genetics*; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D011963:Receptors, GABA-A