title: Central neurocytoma: clinico-pathological study of 5 cases and review of the literature.
abstract: Five cases of central neurocytoma, confirmed by immunohistochemical and electron microscopy studies, are reported and 127 cases from the literature are reviewed. Central neurocytomas are more frequent than previously thought, and will be diagnosed with increasing frequency in the future, if intraventricular tumors with histological aspect of oligodendroglioma or ependymoma will be routinely studied by immunohistochemistry and electron microscopy. The occurrence of an intraventricular tumor with a typical MR aspect in a young patient should suggest preoperatively the diagnosis of neurocytoma. The positivity for synaptophysin and neuron specific enolase, the negativity for neurofilament protein and glial fibrillary acid protein, and the finding of elements of neuronal differentiation on electron microscopy, are the main pathological features of these tumors. Complete removal of the tumor mass without radiotherapy is the treatment of choice. The prognosis is usually favorable without recurrence.
authors.affiliation: Department of Neurosurgery and Pathology, School of Medicine, University Federico II, Naples, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Maiuri
authors.forename: R
authors.initials: R
authors.lastname: Spaziante
authors.forename: M L
authors.initials: ML
authors.lastname: De Caro
authors.forename: P
authors.initials: P
authors.lastname: Cappabianca
authors.forename: A
authors.initials: A
authors.lastname: Giamundo
authors.forename: G
authors.initials: G
authors.lastname: Iaconetta
mesh_terms: D000328:Adult; D014408:Biomarkers, Tumor / Q000032:analysis; D001932:Brain Neoplasms / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D002551:Cerebral Ventricle Neoplasms / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D003937:Diagnosis, Differential; D004806:Ependymoma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007124:Immunoenzyme Techniques; D008279:Magnetic Resonance Imaging; D008297:Male; D008854:Microscopy, Electron; D018306:Neurocytoma / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D009837:Oligodendroglioma / Q000175:diagnosis / Q000473:pathology / Q000601:surgery; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D016708:Synaptophysin / Q000032:analysis
chemical_list: D014408:Biomarkers, Tumor; D016708:Synaptophysin; D010751:Phosphopyruvate Hydratase