[Effect of Allitridi on deforming of peripheral leucocytes in patients with acute cerebral infarction].
To prove the effect of Allitridi in treating acute cerebral infarction, millipore membrane filter technique was adopted in systematically observing the blood rheology and the peripheral WBC filter index of 53 healthy subjects and that of 33 patients before and after treatments, who suffered from acute cerebral infarction and were confirmatorily diagnosed through CT. As a result, the filtered index of peripheral WBC during the acute period of cerebral infarction rose significantly (6.1397 +/- 4.4602), and the difference was significant compared with that of the healthy subjects (0.8651 +/- 0.4603, P < 0.01). Having been treated with Allitridi, the patients' symptoms improved and at the same time the filtered index of WBC lowered markedly (1.6261 +/- 1.3472). The conditions of the patients before and after treatments were obviously different (P < 0.01). And also the index of the whole blood rheology improved significantly. Therefore, it denoted that Allitridi could effectively improve the WBC deformation and the whole blood rheology as well, and alleviate the clinical symptoms.
Mao
J S
JS
China-Japan Friendship Hospital, Beijing.
Shi
Z X
ZX
Zhuang
F Y
FY
D000368:Aged; D000498:Allyl Compounds / Q000494:pharmacology* / Q000627:therapeutic use; D001809:Blood Viscosity / Q000187:drug effects*; D002544:Cerebral Infarction / Q000097:blood* / Q000188:drug therapy; D005260:Female; D005340:Fibrinogen / Q000378:metabolism; D006400:Hematocrit; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology* / Q000627:therapeutic use; D013440:Sulfides / Q000494:pharmacology* / Q000627:therapeutic use
D000498:Allyl Compounds; D010975:Platelet Aggregation Inhibitors; D013440:Sulfides; C042577:diallyl trisulfide; D005340:Fibrinogen