title: Engineering thermostability: lessons from thermophilic proteins.
abstract: As several groups begin to tap the rich pickings found in the Archaea--a vast kingdom that stretches the concept of life as we know it--the structures of proteins from hyperthermophiles are being elucidated. Certain features are beginning to emerge, such as compactness and hydrophobic clustering, but the ability to engineer these features into temperature-intolerant proteins is still some way off.
authors.affiliation: School of Biology and Biochemistry, University of Bath, UK.
authors.forename: R J
authors.initials: RJ
authors.lastname: Russell
authors.forename: G L
authors.initials: GL
authors.lastname: Taylor
mesh_terms: D000596:Amino Acids / Q000032:analysis; D000818:Animals; D001105:Archaea / Q000737:chemistry / Q000502:physiology; D004795:Enzyme Stability; D004798:Enzymes / Q000737:chemistry*; D006358:Hot Temperature; D015202:Protein Engineering; D011506:Proteins / Q000737:chemistry*
chemical_list: D000596:Amino Acids; D004798:Enzymes; D011506:Proteins