title: A non-random chromosome abnormality found in precursor-B lineage acute lymphoblastic leukaemia: dic(9;20)(p1?3;q11).
abstract: A comparison of cytogenetical data on acute lymphoblastic leukaemia studied at four large European centres has revealed a non-random dicentric chromosome abnormality: dic(9;20) (p1?3;q11) in 10 patients, nine of whom were children. All had early precursor-B lineage ALL, and eight children had a non-standard risk clinical presentation. The origin of the dicentric chromosome was demonstrated using a range of chromosome banding techniques. This was confirmed by FISH using paints and centromeric probes for chromosomes 9 and 20, together with a number of cosmid probes. The follow-up time of these patients is presently too short and the number of patients too few to determine the prognostic significant of this chromosome abnormality.
authors.affiliation: Institute of Human Genetics, University of Amsterdam, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Slater
authors.forename: E
authors.initials: E
authors.lastname: Smit
authors.forename: W
authors.initials: W
authors.lastname: Kroes
authors.forename: M J
authors.initials: MJ
authors.lastname: Bellomo
authors.forename: D
authors.initials: D
authors.lastname: Mühlematter
authors.forename: J
authors.initials: J
authors.lastname: Harbott
authors.forename: H
authors.initials: H
authors.lastname: Behrendt
authors.forename: K
authors.initials: K
authors.lastname: Hählen
authors.forename: A J
authors.initials: AJ
authors.lastname: Veerman
authors.forename: A
authors.initials: A
authors.lastname: Hagemeijer
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D005260:Female; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007223:Infant; D007621:Karyotyping; D008297:Male; D015452:Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000235:genetics*