In vivo radioprotective effect of chlorophyllin on sister chromatid exchange induction in murine spermatogonial cells.
The radioprotective capacity of chlorophyllin was determined by measuring the reduction of gamma-ray-induced sister chromatid exchange (SCE) in murine spermatogonia in vivo. The results obtained in experiments using 100 and 200 micrograms of chlorophyllin per gram of body weight (bw) and irradiated either before or after BrdU incorporation, indicate that a chlorophyllin dose of 200 micrograms/g bw protects 100% against the induction of SCE by 0.75 Gy of gamma-rays and 100 micrograms/g bw protects less than 50%. Chlorophyllin per se did not have any effect on the SCE frequency.
Morales-Ramírez
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Instituto Nacional de Investigaciones Nucleares, Mexico, D.F., Mexico.
Mendiola-Cruz
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MT
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001973:Bromodeoxyuridine / Q000378:metabolism; D002735:Chlorophyllides / Q000494:pharmacology*; D005720:Gamma Rays; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D012854:Sister Chromatid Exchange; D013093:Spermatogonia / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism / Q000528:radiation effects
D016587:Antimutagenic Agents; D002735:Chlorophyllides; D011837:Radiation-Protective Agents; C007020:chlorophyllin; D001973:Bromodeoxyuridine