Latent autoimmune diabetes mellitus in adult humans with non-insulin-dependent diabetes: is Psammomys obesus a suitable animal model?
Recent data suggest that in a proportion of NIDDM patients there is a slowly evolving insulitis which results in a latent autoimmune diabetes leading to full insulin-dependence. Many animal models exist of NIDDM but none have reported the spontaneous existence of a similar phenomenon. We have re-examined the histology of pancreata from a few Psammomys obesus who had become insulin-dependent in the late stages of NIDDM. We report here the unexpected finding of the presence of insulitis in these animals and suggest that they could be a model for the clinical observation of latent IDDM in NIDDM patients.
Duhault
J
J
Division of Metabolic Diseases, Institut de Recherches Servier, Suresnes, France.
Boulanger
M
M
Espinal
J
J
Marquié
G
G
Petkov
P
P
du Boistesselin
R
R
D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology*; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology / Q000473:pathology* / Q000503:physiopathology*; D004195:Disease Models, Animal; D005849:Gerbillinae; D006801:Humans; D007328:Insulin / Q000097:blood; D007515:Islets of Langerhans / Q000276:immunology / Q000473:pathology*; D008214:Lymphocytes / Q000276:immunology / Q000473:pathology
D001786:Blood Glucose; D007328:Insulin