[Treatment of solid tumor by a small amount of direct current].
Solid tumor treatment was given in our animal laboratory to determine the mechanism of tumor disappearance by direct electric current, and clinical trials were done on 9 far advanced recurrent rectal cancers. Solid tumors of Yoshida sarcoma in Donryu rat were treated by 1 mA of constant direct current for 1 hour a day, for 4 days. The tumors disappeared in 13/16 within 21 days. Positive results of DNA Nick-end labeling and ladder patterns in the gel electrophoresis of DNA were observed in the regressing tumor specimen. It is considered that apoptosis is the one of the mechanisms of a disappearing tumor. As for the clinical trial concern, in 9 cases of rectal cancer, one CR and 5 PR were seen.
Ito
K
K
Dept. of Surgery II, School of Medicine, Nagoya University.
Ye
C L
CL
Kondou
K
K
Akiyama
S
S
Takagi
H
H
Hirota
H
H
Endo
T
T
Itoh
G
G
Suzuki
M
M
Ikeda
S
S
D000368:Aged; D000818:Animals; D017209:Apoptosis; D004599:Electric Stimulation Therapy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D051381:Rats; D012004:Rectal Neoplasms / Q000628:therapy*; D012517:Sarcoma, Yoshida / Q000473:pathology / Q000628:therapy*