title: Effects of carbamazepine and valproate on brainstem auditory evoked potentials in epileptic children.
abstract: Brainstem auditory evoked potentials (BAEPs) were recorded in 18 epileptic children receiving carbamazepine and 10 epileptic children receiving valproate. BAEPs were recorded before the administration of antiepileptic drugs (AEDs) and 13 months later during which the children received AEDs. Statistical analysis of peak latencies and interpeak intervals of waves I-III-V were made. Carbamazepine treatment resulted in prolongation of peak latencies of waves I-III-V and interpeak intervals I-III and I-V. Valproate monotherapy, on the other hand, caused no consistent changes on BAEP. On the basis of these results we suggest that chronic carbamazepine therapy exerts a suppressive influence on the auditory pathways, both peripherally at the level of the cochlea and/or auditory nerve, and centrally at the brainstem.
authors.affiliation: Department of Pediatric Neurology, Istanbul University, Cerrahpasa Faculty of Medicine, Turkey.
authors.forename: A
authors.initials: A
authors.lastname: Yuksel
authors.forename: D
authors.initials: D
authors.lastname: Senocak
authors.forename: D
authors.initials: D
authors.lastname: Sozuer
authors.forename: G
authors.initials: G
authors.lastname: Keskin
authors.forename: A
authors.initials: A
authors.lastname: Dirican
authors.forename: A
authors.initials: A
authors.lastname: Cenani
authors.forename: E
authors.initials: E
authors.lastname: Yalcin
mesh_terms: D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D001306:Auditory Pathways / Q000187:drug effects; D001933:Brain Stem / Q000187:drug effects; D002220:Carbamazepine / Q000009:adverse effects / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004828:Epilepsies, Partial / Q000188:drug therapy; D004827:Epilepsy / Q000188:drug therapy*; D004829:Epilepsy, Generalized / Q000188:drug therapy; D016057:Evoked Potentials, Auditory, Brain Stem / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D011930:Reaction Time / Q000187:drug effects; D014635:Valproic Acid / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D000927:Anticonvulsants; D002220:Carbamazepine; D014635:Valproic Acid