title: [Treatment with cyclosporine of refractory rheumatoid arthritis].
abstract: Cyclosporine may be useful in the treatment of rheumatoid arthritis refractory to other immunosuppressive agents, in doses of less than 10 mg/kg/day to minimize its nephrotoxic potential, that is enhanced with prolonged use or concomitant administration of anti-inflammatory drugs. We report 15 patients aged 50 +/- 12 years with erosive rheumatoid arthritis lasting 5 +/- 4 years and refractory to other immunosuppressive agents. They were studied during one year and received cyclosporine in initial doses of 2.5 mg/kg/day that were increased to 5 mg/kg/day, assessing clinical response, blood pressure and serum creatinine. Nine patients, that received a maximal dose of 3.4 +/- 0.7 mg/kg/day during 7 +/- 4 months, improved; a 30% increase in creatinine was observed in 3, blood pressure raised in six and two had hepatic toxicity. In the six patients that did not improve, the mean treatment lapse was 4 +/- 3 months and the maximal dose achieved was 2.7 mg/kg/day; creatinine increased in one and blood pressure increased in 4. It is concluded that although the clinical response to cyclosporine was good, only 4 patients completed one year of treatment, due to the frequent secondary effects of the drug.
authors.affiliation: Departamento de Reumatología e Inmunología Clínica, Escuela de Medicina, P Universidad Católica de Chile, Santiago de Chile.
authors.forename: L
authors.initials: L
authors.lastname: Massardo
authors.forename: S
authors.initials: S
authors.lastname: Jacobelli
authors.forename: F
authors.initials: F
authors.lastname: Figueroa
authors.forename: F
authors.initials: F
authors.lastname: Gutiérrez
authors.forename: M E
authors.initials: ME
authors.lastname: Martínez
authors.forename: S
authors.initials: S
authors.lastname: Rivero
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000627:therapeutic use*; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D001794:Blood Pressure / Q000187:drug effects; D003404:Creatinine / Q000097:blood; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D018501:Antirheumatic Agents; D016572:Cyclosporine; D003404:Creatinine
vernacular_title: Tratamiento con ciclosporina de la artritis reumatoídea refractaria.