Levels of antioxidant nutrients in plasma and low density lipoproteins: a human volunteer supplementation study.
A human supplementation study was undertaken in order to investigate the correlation between the intake of individual daily dosages of vitamin E (300 mg), vitamin C (250 mg), or beta-carotene (15 mg) of eight week duration and their uptake in vivo in plasma and LDL. The effects of a combined supplement of vitamin E, vitamin C and beta-carotene (Redoxon protector-75 mg, 150 mg, 15 mg respectively) were also investigated. The results show that on supplementation with the individual antioxidants the increases in plasma alpha-tocopherol:cholesterol levels lie in the 1.5-2 fold range and the beta-carotene:cholesterol ratios give a mean 3.5 fold enhancement. The combined supplement containing the same level of beta-carotene as the single dosage achieved comparative levels of uptake in plasma. The level of plasma vitamin C appears to be maximal at about 100 microM regardless of the pre-supplementation level.
Calzada
C
C
Division of Biochemistry and Molecular Biology, UMDS Guy's Hospital, London, UK.
Bizzotto
M
M
Paganga
G
G
Miller
N J
NJ
Bruckdorfer
K R
KR
Diplock
A T
AT
Rice-Evans
C A
CA
D000328:Adult; D000975:Antioxidants / Q000032:analysis / Q000378:metabolism* / Q000494:pharmacology; D001205:Ascorbic Acid / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology; D002338:Carotenoids / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology; D002784:Cholesterol / Q000097:blood; D005260:Female; D005527:Food, Fortified; D006801:Humans; D008077:Lipoproteins, LDL / Q000097:blood* / Q000187:drug effects; D008297:Male; D008875:Middle Aged; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood* / Q000494:pharmacology; D019207:beta Carotene
D000975:Antioxidants; D008077:Lipoproteins, LDL; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids; D002784:Cholesterol; D001205:Ascorbic Acid