title: [Analysis of course and treatment results after treatment of pulmonary tuberculosis with early introduction of interrupted observation--preliminary report].
abstract: The results of the treatment 33 patients for smear-positive pulmonary tuberculosis with Isoniazid, Rifampicin, Pyrazinamide and Streptomycin administrated during first two weeks daily, from 3 to 8 week also with these four drugs but in a little higher doses twice weekly and next Isoniazid and Rifampicin during 9-26 weeks also twice weekly as in standard Polish model were described. After therapy with above described regimen all patients became smear-negative and radiological improvement was observed. Drugs in higher doses were well tolerated. Only abnormality in laboratory findings was temporary elevated level of uric acid, which recovered to normal values before the end of therapy. Costs of antituberculous drugs were used in this regimen is approximately 35% lower than standard model in Poland.
authors.affiliation: Kliniki Chorób Płuc i Gruźlicy Pomorskiej Akademii Medycznej w Szczecinie.
authors.forename: A M
authors.initials: AM
authors.lastname: Sedlaczek
authors.forename: P
authors.initials: P
authors.lastname: Serwatowski
authors.forename: W
authors.initials: W
authors.lastname: Spiewak
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000995:Antitubercular Agents / Q000008:administration & dosage*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000008:administration & dosage; D008297:Male; D008875:Middle Aged; D011718:Pyrazinamide / Q000008:administration & dosage; D012293:Rifampin / Q000008:administration & dosage; D013307:Streptomycin / Q000008:administration & dosage; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D014527:Uric Acid / Q000378:metabolism
chemical_list: D000995:Antitubercular Agents; D014527:Uric Acid; D011718:Pyrazinamide; D007538:Isoniazid; D012293:Rifampin; D013307:Streptomycin
vernacular_title: Analiza przebiegu i wyników leczenia gruźlicy płuc z wczesnym wprowadzeniem kuracji nadzorowanej metoda przerywana--doniesienie wstepne.