Increase of a guinea pig natural killer cell (Kurloff cell) during leukemogenesis.
The guinea pig Kurloff cell (KC) is an estradiol-dependent circulating mononuclear cell that had natural killer cytotoxic activity in vitro. We studied the variation of KC number during the development of transplanted leukemia in inbred strain 2 (S2) leukemia-sensitive guinea pigs. Grafts of leukemic cells (L2C) produced a significant increase in the number of KC. Leukemia occurred in 35.5% of non-estrogenized animals and in 18.3% of estrogenized guinea pigs. The increased number of KC seems to have antileukemia activity in vivo. This could be part of the general phenomenon of cancer resistance in guinea pigs.
Debout
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C
Laboratoire d'Histologie et de Biologie cellulaire, UFR de Médecine, CHU Côte de Nacre, Caen France.
Taouji
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S
Izard
J
J
D000818:Animals; D004958:Estradiol / Q000494:pharmacology; D006168:Guinea Pigs / Q000276:immunology*; D007111:Immunity, Cellular; D007178:Inbreeding; D007694:Killer Cells, Natural / Q000276:immunology*; D007942:Leukemia, Experimental / Q000276:immunology*; D008297:Male; D009368:Neoplasm Transplantation
D004958:Estradiol