In-vitro analyses of mechanisms of B-cell development.
B-cell lymphopoiesis in vivo is very complex due to the influences of cooperating cells, cytokines and other receptor-ligand interactions which appear to occur developmentally at different cellular stages. Therefore in-vitro models will help to unravel this complex situation. Here, we review our and others' work on in-vitro models of B-cell development. The role of stromal cells, cytokines, surrogate light chain and products of rearranged Ig-loci in the developmentally different cellular stages will be discussed.
Rolink
A
A
Basel Institute for Immunology, Switzerland.
Ghia
P
P
Grawunder
U
U
Haasner
D
D
Karasuyama
H
H
Kalberer
C
C
Winkler
T
T
Melchers
F
F
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology*; D002454:Cell Differentiation / Q000276:immunology*; D002478:Cells, Cultured; D006412:Hematopoietic Stem Cells / Q000276:immunology*; D051379:Mice; D018448:Models, Immunological