title: Magnetic resonance imaging reveals no ventriculomegaly in polydrug abusers.
abstract: Previous studies of cerebral structure in substance abusers yielded controversial results, largely due to issues of subject selection and/or limitations of experimental techniques. The purpose of the present study was to assess whether the ventricle-to-brain ratio (VBR), determined volumetrically by magnetic resonance imaging (MRI), differed in polysubstance abusers (n = 10), as compared with age-matched controls (n = 10). Subjects were male volunteers 21-39 years of age. The values of VBR in the polydrug abuse group were not larger than those in control group, nor was there any tendency toward relative ventriculomegaly in the substance abusers. Therefore, the present findings provide no evidence that polysubstance abuse produces abnormalities of gross brain structure in relatively young and physically healthy men.
authors.affiliation: Division of Intramural Research, National Institute on Drug Abuse, National Institutes of Health, Baltimore, MD 21224, USA.
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: R L
authors.initials: RL
authors.lastname: Phillips
authors.forename: S M
authors.initials: SM
authors.lastname: Resnick
authors.forename: V L
authors.initials: VL
authors.lastname: Villemagne
authors.forename: D F
authors.initials: DF
authors.lastname: Wong
authors.forename: J M
authors.initials: JM
authors.lastname: Stapleton
authors.forename: E D
authors.initials: ED
authors.lastname: London
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000175:diagnosis; D001921:Brain / Q000187:drug effects / Q000473:pathology; D002552:Cerebral Ventricles / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D006984:Hypertrophy; D013287:Illicit Drugs; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D008297:Male; D011619:Psychotropic Drugs; D012016:Reference Values; D019966:Substance-Related Disorders / Q000175:diagnosis*
chemical_list: D013287:Illicit Drugs; D011619:Psychotropic Drugs