title: Interfacial metal-binding site design.
abstract: In recent years, much attention has focused on the characterization of metal-binding sites in natural metalloproteins and the design of novel metal-binding motifs. As a result, it is now possible to harness the high specificity and potency of metal-ion binding to modulate intermolecular interactions. Some encouraging results have been obtained using designed metal-binding sites in such diverse applications as the stabilization of artificial peptide assembly, regulation of membrane channels, control of enzyme activity and enhancement of hormone-receptor interactions.
authors.affiliation: Arris Pharmaceutical Corporation, South San Francisco, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Matthews
mesh_terms: D001665:Binding Sites; D002846:Chromatography, Affinity; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D004798:Enzymes / Q000737:chemistry* / Q000378:metabolism; D005656:Fungal Proteins / Q000737:chemistry / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D015202:Protein Engineering / Q000379:methods*; D011494:Protein Kinases / Q000737:chemistry / Q000378:metabolism; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D029701:Saccharomyces cerevisiae Proteins
chemical_list: D004268:DNA-Binding Proteins; D004798:Enzymes; D005656:Fungal Proteins; D008565:Membrane Proteins; D008670:Metals; D011506:Proteins; D029701:Saccharomyces cerevisiae Proteins; D011494:Protein Kinases