[Blood of patients with acute leukemia increases the leukocyte count in the peripheral blood of mice].
Serum of 23 patients suffering from acute myeloid leukemia were given to groups of six mice (s.c. 0.6 ml); 3 and 5 days later the total number of leucocytes, granulocytes and lymphocytes was determined in the peripheral blood of mice. Serums of all patients caused significant increase of leucocytes in mice 3 and/or 5 days after the serum's application. In most cases the increase was caused by increased number of granulocytes and lymphocytes, and in 6 cases only by increase of granulocytes or only lymphocytes. This increase can also be thought of as a stimulation of leukocytopoiesis by increased concentration of hematopoetic growth factors in blood of those suffering from acute leukemia.
Borota
R
R
Zavod za patolosku fiziologiju i laboratorijsku dijagnostiku, Medicinski fakultet, Novi Sad.
Temerinac
S
S
Borota
J
J
Savić
A
A
Uzurov
V
V
D000208:Acute Disease; D000818:Animals; D001790:Blood Physiological Phenomena; D006410:Hematopoiesis; D006801:Humans; D007951:Leukemia, Myeloid / Q000097:blood*; D007958:Leukocyte Count; D007962:Leukocytes; D051379:Mice
Serum bolesnika obolelih od akutne leukemije povećava broj leukocita u perifernoj krvi miseva.