title: Synergistic interaction between ORM1 and C3 types in disease associations.
abstract: In previous studies of orosomucoid (ORM) types and disease the ORM1 1 type has been found to be associated with sarcoidosis and other immunogenetic diseases, and the ORM 1 2 type with different types of carcinomas. We report significant associations between ORM1 and C3 types in sarcoidosis and breast cancer, but not in healthy individuals. The ORM1 1 and C3S variants in combination increased the risk of sarcoidosis, and the ORM1 2 and C3F variants together gave an increased risk of breast cancer. A probable mechanism may be that the ORM1 and C3 molecules modify the immune response by interacting with the lymphoid cell surface.
authors.affiliation: Department of Medical Genetics, Umeå University, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Fan
authors.forename: P O
authors.initials: PO
authors.lastname: Nylander
authors.forename: U
authors.initials: U
authors.lastname: Stendahl
authors.forename: M
authors.initials: M
authors.lastname: Thunell
authors.forename: L
authors.initials: L
authors.lastname: Beckman
mesh_terms: D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000276:immunology; D003176:Complement C3 / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000737:chemistry; D009961:Orosomucoid / Q000737:chemistry* / Q000235:genetics; D011110:Polymorphism, Genetic; D012507:Sarcoidosis / Q000235:genetics* / Q000276:immunology
chemical_list: D003176:Complement C3; D007166:Immunosuppressive Agents; D009961:Orosomucoid