title: Biosynthesis of brominated tyrosine metabolites by Aplysina fistularis.
abstract: The biosynthesis of brominated tyrosine metabolites by the marine sponge Aplysina fistularis was investigated. [U-14C]-L-Tyrosine, [U-14C]-L-3-bromotyrosine, and [U-14C]-L-3,5-dibromotyrosine were incorporated into both dibromoverongiaquinol [1] and aeroplysinin-1 [2], and [methyl-14C]methionine was specifically incorporated into the O-methyl group group of 2. [Methyl-14C]-L-O-methyltyrosine, [methyl-14C]-L-3,5-dibromo-O-methyltyrosine, and several putative nitrile precursors were not incorporated into 1 or 2.
authors.affiliation: Roger Adams Laboratory, University of Illinois, Urbana 61801, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: Carney
authors.forename: K L
authors.initials: KL
authors.lastname: Rinehart
mesh_terms: D000818:Animals; D001966:Bromine / Q000378:metabolism*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D011161:Porifera / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D014443:Tyrosine / Q000096:biosynthesis*
chemical_list: D014443:Tyrosine; D001966:Bromine