C-Fos-like immunoreactivity in the cat brainstem evoked by sneeze-inducing air puff stimulation of the nasal mucosa.
Sneeze is one of the most important protective reflex of the respiratory tract. It is elicited from trigeminal peripheral fields and results in major changes in the discharge patterns of the medullary respiratory-related neurons. The pattern of c-Fos-like immunoreactivity evoked by sneezing was explored as a structural approach to the networks involved in this particular model of trigemino--respiratory interactions. Sneezes were elicited in anaesthetized adult cats by driving air puffs to the superior nasal meatus through a catheter. Additional cats were used as controls for anaesthesia and for catheter insertion into the nostril. In sneezing cats, immunoreactivity was evoked in projection areas of the ethmoidal afferents which innervate the superior nasal meatus, e.g. the subnuclei caudalis, interpolaris and in the interstitial islands of the trigeminal sensory complex. Immunoreactivity was also markedly enhanced in the areas devoted to respiratory control in the medulla (solitary complex, nucleus retroambiguus) and in the pontine parabrachial area. C-Fos expression was also evoked in the lateral aspect of the parvicellular reticular formation in sneezing cats. This area might be of major importance in the adaptation of the ventilatory system to expulsive functions.
Wallois
F
F
Laboratoire de Neurophysiologie, CNRS URA 1331, UFR de Médecine, Université de Picardie, Amiens, France.
Gros
F
F
Masmoudi
K
K
Larnicol
N
N
D000758:Anesthesia; D000818:Animals; D001933:Brain Stem / Q000378:metabolism*; D002415:Cats; D007150:Immunohistochemistry; D009297:Nasal Mucosa / Q000502:physiology*; D010477:Perfusion; D010812:Physical Stimulation; D011149:Pons / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D012018:Reflex / Q000502:physiology; D012154:Reticular Formation / Q000378:metabolism; D012912:Sneezing / Q000502:physiology*; D017552:Solitary Nucleus / Q000166:cytology / Q000502:physiology; D016707:Tissue Fixation; D014276:Trigeminal Nerve / Q000378:metabolism / Q000502:physiology
D016760:Proto-Oncogene Proteins c-fos