title: Exclusion of copper from altered hepatocytes in white perch (Morone americana) with hepatic copper storage.
abstract: Iron is excluded from foci of hepatocellular alteration in carcinogenesis of rodents and some fish. Among white perch (Morone americana), there is a condition of hepatic copper storage in which copper-loaded livers are produced naturally. In a group of fish collected from the Chesapeake Bay, Maryland (USA), from September to December 1990, we observed hepatic lesions which excluded copper similar to the phenomenon of iron exclusion, in a white perch with over 3,600 micrograms/g wet weight hepatic copper. The lesions were of two types: one with cells morphologically different from normal hepatocytes and which had diminished to absolute exclusion of copper with the copper specific histochemical stain rubeinic acid, and a second with cells morphologically similar to normal hepatocytes which had only a partial exclusion of copper. Although the exact cause and nature of the lesions was not determined, intrinsic copper toxicity, environmental pollution, or a combination of these factors may have contributed to their development.
authors.affiliation: Division of Comparative Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: T E
authors.initials: TE
authors.lastname: Bunton
mesh_terms: D000818:Animals; D006528:Carcinoma, Hepatocellular / Q000139:chemically induced / Q000378:metabolism / Q000662:veterinary; D002455:Cell Division / Q000187:drug effects; D003300:Copper / Q000009:adverse effects / Q000378:metabolism*; D005260:Female; D005393:Fish Diseases / Q000378:metabolism*; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced / Q000378:metabolism / Q000662:veterinary; D010471:Perches
chemical_list: D003300:Copper