Evidence for three tumor suppressor gene loci on chromosome 8p in human prostate cancer.
Allelic loss of human chromosome sequences is often equated with inactivation of putative tumor suppressor genes. Loss of sequences on the short arm of chromosome 8 (8p) has been observed in human cancers, especially of 8p22 in prostate tumors. By using PCR analysis of highly polymorphic microsatellite repeat markers at nine 8p loci in 135 tumors, we observed deletion of sequences at 8p22 and at two other proximal deletion domains. These novel deletion domains encompass the NEFL locus and D8S87-ANK1 loci, respectively. These data suggest that three 8p tumor suppressor gene loci may be independently deleted in human prostate cancers.
Macoska
J A
JA
Department of Surgery, University of Michigan, Ann Arbor 48109-0680, USA.
Trybus
T M
TM
Benson
P D
PD
Sakr
W A
WA
Grignon
D J
DJ
Wojno
K D
KD
Pietruk
T
T
Powell
I J
IJ
D000328:Adult; D000368:Aged; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002898:Chromosomes, Human, Pair 8; D004276:DNA, Satellite / Q000235:genetics; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D017430:Prostate-Specific Antigen / Q000097:blood; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery
D004276:DNA, Satellite; D017430:Prostate-Specific Antigen