title: Intracellular signalling. Switching off signals.
abstract: In hematopoietic cells, the protein tyrosine phosphatase PTP1C appears to play a central role in the termination of signalling by receptors that activate protein tyrosine kinases.
authors.affiliation: Department of Medicine, Veterans Affairs Medical Center, San Francisco, California, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Imboden
authors.forename: G A
authors.initials: GA
authors.lastname: Koretsky
mesh_terms: D000818:Animals; D004789:Enzyme Activation; D006412:Hematopoietic Stem Cells / Q000201:enzymology / Q000378:metabolism*; D047908:Intracellular Signaling Peptides and Proteins; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases / Q000378:metabolism*; D011505:Protein-Tyrosine Kinases / Q000378:metabolism*; D015398:Signal Transduction
chemical_list: D047908:Intracellular Signaling Peptides and Proteins; D011505:Protein-Tyrosine Kinases; D054592:Protein Tyrosine Phosphatase, Non-Receptor Type 11; D053824:Protein Tyrosine Phosphatase, Non-Receptor Type 6; D017027:Protein Tyrosine Phosphatases