The effect of dexamethasone on the course of Echinostoma caproni and E. trivolvis infections in the golden hamster (Mesocricetus auratus).
Golden hamsters (Mesocricetus auratus) were given intramuscular injections of dexamethasone and infected with Echinostoma caproni or E. trivolvis. All animals were necropsied on day 14 postinfection. Dexamethasone treatment at high doses resulted in increased parasite recovery. Decreased total white blood cell counts and decreased relative splenic weights were observed in corticosteroid-treated hamsters. Dexamethasone-treated animals also demonstrated significantly lower mean parasite dry weights for E. caproni. Specific serum IgG against the parasites was not detected in corticosteroid-treated hamsters on day 14 postinfection.
McMaster
R P
RP
Department of Biological Sciences, East Stroudsburg University, PA 18301, USA.
Huffman
J E
JE
Fried
B
B
D000818:Animals; D006224:Cricetinae; D003907:Dexamethasone / Q000494:pharmacology*; D004449:Echinostoma / Q000472:pathogenicity; D004451:Echinostomiasis / Q000276:immunology* / Q000473:pathology; D005938:Glucocorticoids / Q000494:pharmacology*; D007113:Immunity, Innate; D007165:Immunosuppression Therapy; D007958:Leukocyte Count; D008647:Mesocricetus; D009929:Organ Size; D013154:Spleen / Q000473:pathology; D013997:Time Factors
D005938:Glucocorticoids; D003907:Dexamethasone