Activity of area 5 neurons in monkeys during arm movements: effects of dentate nucleus lesion and motor cortex ablation.
Area 5 movement-related neurons were recorded in two trained monkeys respectively before and after (i) bilateral lesion of the dentate nucleus (DN), (ii) ablation of the motor cortex (area 4). DN lesion does not modify the proportion of early (command) and late (somaesthetic) neuronal changes. It does, however, increase both cellular and behavioural reaction times. The ablation of area 4 induces a clear-cut increase in the number of early neuronal changes during the period of recovery from arm palsy. These results show that: (i) the neocerebellum enhances the excitability of area 5 movement-related neurons; (ii) area 5 may compensate for the deficiency in area 4 by unmasking silent neurons and thereby subserves rehabilitation mechanisms.
Bioulac
B
B
Laboratoire de Neurophysiologie, CNRS URA 1200, Université de Bordeaux II, France.
Burbaud
P
P
Varoqueaux
D
D
D000818:Animals; D001132:Arm / Q000502:physiology; D001259:Ataxia / Q000503:physiopathology; D002529:Cerebellar Nuclei / Q000502:physiology*; D002531:Cerebellum / Q000502:physiology; D002540:Cerebral Cortex / Q000166:cytology; D002541:Cerebral Decortication; D004594:Electrophysiology; D008253:Macaca mulatta / Q000502:physiology*; D009046:Motor Neurons / Q000502:physiology*; D009068:Movement / Q000502:physiology*; D009434:Neural Pathways