Choroidal blastomycosis. A report of two cases.
OBJECTIVE
To review the presentation and course of choroidal blastomycosis, a rare chorioretinal mycotic infection, which results from disseminated blastomycosis.


METHODS
Two cases of disseminated blastomycosis with ocular infection limited to the choroid are presented. Each patient was diagnosed through biopsy of skin lesions demonstrating the characteristic histologic features and the budding yeast.


RESULTS
Systemic evaluation revealed extensive disseminated disease with involvement of the eye, lung, skin, bone and joint, central nervous system, and genitourinary system. Both patients were successfully treated with intravenous amphotericin B with elimination of ocular and systemic disease.


CONCLUSIONS
Although rare, blastomycosis can result in choroidal mycotic infection in immune competent individuals. Tissue biopsy to confirm the diagnosis and extensive systemic evaluation are required.
Gottlieb
J L
JL
Kellogg Eye Center, University of Michigan, Ann Arbor, USA.
McAllister
I L
IL
Guttman
F A
FA
Vine
A K
AK
D000328:Adult; D000666:Amphotericin B / Q000627:therapeutic use; D001758:Blastomyces / Q000302:isolation & purification; D001759:Blastomycosis / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D001927:Brain Diseases / Q000000981:diagnostic imaging / Q000382:microbiology; D002829:Choroid / Q000382:microbiology; D015862:Choroid Diseases / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology*; D003881:Dermatomycoses / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology; D015821:Eye Infections, Fungal / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005654:Fundus Oculi; D006225:Hand / Q000000981:diagnostic imaging; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D010019:Osteomyelitis / Q000000981:diagnostic imaging / Q000382:microbiology; D011877:Radionuclide Imaging; D012867:Skin / Q000382:microbiology; D014057:Tomography, X-Ray Computed
D000666:Amphotericin B