Cerebrospinal fluid dissemination of fetal neural isografts in brain of adult rats.
Our previous studies tend to document the temporary invasiveness of intraparenchymal fetal isografts. The present study exploits a model situation in which contacted host brain surface remains undamaged. We analyzed the behavior of transplant fragments that accidentally disseminated in cerebrospinal fluid pathways. The transplant seeding occurred in 7 cases out of 85 cases of healthy solid isografts taken from various parts of fetal brain. Fragments were found either as free (floating or simply lying close to the surface) or attached. Some attached fragments invasively penetrated the brain parenchyma. This speaks in favor of invasive properties of fetal neural transplants.
Nĕmecek
S
S
Department of Histology and Embryology, Medical Faculty Charles University.
Mokrý
J
J
Mazurová
Y
Y
Subrtová
D
D
D000818:Animals; D001921:Brain / Q000166:cytology; D016380:Brain Tissue Transplantation; D002555:Cerebrospinal Fluid / Q000166:cytology*; D016332:Fetal Tissue Transplantation; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains