Molecular foundations of cancer: new targets for intervention.
Conceptual and practical advances in molecular medicine are changing our understanding of cancer pathogenesis. In time this should provide the opportunity to alter the natural history of many cancers.
Karp
J E
JE
National Cancer Institute, Bethesda, Maryland 20892, USA.
Broder
S
S
D000818:Animals; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors* / Q000502:physiology; D016213:Cyclins / Q000037:antagonists & inhibitors* / Q000502:physiology; D006801:Humans; D008967:Molecular Biology; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
D016213:Cyclins; D016159:Tumor Suppressor Protein p53; D018844:Cyclin-Dependent Kinases