Destructive lymphadenopathy and T-lymphocyte activation in adult-onset Still's disease.
Recurrent arthritis, fever and lymphadenopathy are symptoms of adult onset of Still's disease (AOSD). Differential diagnosis requires the exclusion of infections or malignant lymphomas. We report on a case of AOSD showing destructive lymphadenopathy, immunophenotyping of peripheral blood leucocytes revealed strong activation of T-lymphocytes. Bone marrow biopsy also showed an increase of lymphopoietic cells to 23%. Analysis of peripheral blood lymphocytes (PBL) after remission showed no remaining signs of activation. Analysis of lymphocyte activation by flow cytometry correlated with disease activity.
Koeller
M
M
Department of Internal Medicine III, University of Vienna, Austria.
Kiener
H
H
Simonitsch
I
I
Aringer
M
M
Steiner
C W
CW
Machold
K
K
Graninger
W
W
D000328:Adult; D005260:Female; D006801:Humans; D008206:Lymphatic Diseases / Q000209:etiology / Q000473:pathology*; D008213:Lymphocyte Activation; D016706:Still's Disease, Adult-Onset / Q000150:complications*; D013601:T-Lymphocytes / Q000276:immunology / Q000473:pathology*