title: Plasma levels of IL-1, TNF alpha, IL-6, IL-8, G-CSF, and IL1-RA during febrile neutropenia: results of a prospective study in patients undergoing chemotherapy for acute myelogenous leukemia.
abstract: Plasma levels of IL-1, IL-6, IL-8, IL1-RA, TNF alpha, and G-CSF were prospectively studied during 23 chemotherapy cycles of 20 patients suffering from acute myelogenous leukemia. Increased plasma levels of IL-6, IL-8, and G-CSF were observed in patients with febrile neutropenia and/or major infection. Plasma levels of IL-6, IL-1, TNF alpha and IL-1-RA measured 1 day before and 1 day after the onset of febrile episodes did not accurately predict the development of major infection. In contrast, IL-8 plasma levels were significantly higher in those patients who subsequently developed major infection. The question whether IL-8 plasma levels identify high risk or low risk patients with sufficient specificity and sensitivity has to be answered in large scale clinical trials.
authors.affiliation: Department of Microbiology, University Hospital Mainz, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Schönbohn
authors.forename: M
authors.initials: M
authors.lastname: Schuler
authors.forename: K
authors.initials: K
authors.lastname: Kolbe
authors.forename: C
authors.initials: C
authors.lastname: Peschel
authors.forename: C
authors.initials: C
authors.lastname: Huber
authors.forename: W
authors.initials: W
authors.lastname: Bemb
authors.forename: W E
authors.initials: WE
authors.lastname: Aulitzky
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage; D016207:Cytokines / Q000097:blood*; D003606:Dacarbazine / Q000008:administration & dosage; D005260:Female; D005334:Fever; D016179:Granulocyte Colony-Stimulating Factor / Q000097:blood; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000037:antagonists & inhibitors; D007376:Interleukin-2 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D016209:Interleukin-8 / Q000097:blood; D015470:Leukemia, Myeloid, Acute / Q000097:blood / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D008942:Mitoxantrone / Q000008:administration & dosage; D009503:Neutropenia / Q000097:blood* / Q000209:etiology; D015376:Nimustine / Q000008:administration & dosage; D011446:Prospective Studies; D012795:Sialoglycoproteins / Q000097:blood; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis; D014750:Vincristine / Q000008:administration & dosage
chemical_list: D000964:Antimetabolites, Antineoplastic; D016207:Cytokines; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D007376:Interleukin-2; D015850:Interleukin-6; D016209:Interleukin-8; D012795:Sialoglycoproteins; D014409:Tumor Necrosis Factor-alpha; D003561:Cytarabine; D015376:Nimustine; D016179:Granulocyte Colony-Stimulating Factor; D014750:Vincristine; D003606:Dacarbazine; D008942:Mitoxantrone