Sequence of the 5' regulatory domain of the gene encoding the rat beta 2-adrenergic receptor.
Restriction mapping and sequence analysis of the gene encoding the rat beta 2 adrenergic receptor (beta 2AR) revealed an error affecting most of the 5'-flanking domain, located between -192 and -2245 bp in the only published sequence of this gene [Buckland et al., Nucleic Acids Res. 18 (1990) 682]. The correct sequence lacks a TATA box, contains 67% G + C residues in the first 500 nucleotides upstream from the start codon, and contains putative glucocorticoid, thyroid hormone and cAMP-response elements.
Jiang
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Department of Pharmacology and Toxicology, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.
Kunos
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G
D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D050990:GATA3 Transcription Factor; D008969:Molecular Sequence Data; D051381:Rats; D018343:Receptors, Adrenergic, beta-2 / Q000737:chemistry / Q000235:genetics*; D014157:Transcription Factors / Q000096:biosynthesis / Q000235:genetics*
D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; D018343:Receptors, Adrenergic, beta-2; D014157:Transcription Factors