title: Molecular mechanisms of APO-1/Fas(CD95)-mediated apoptosis in tolerance and AIDS.
abstract: The cell surface molecule APO-1/Fas(CD95), a member of the Tumor Necrosis Factor (TNF) receptor/Nerve Growth Factor (NGF) receptor superfamily mediates apoptosis upon cross-linking by agonistic antibodies or its ligand. Recent findings suggest that APO-1/Fas(CD95) and its ligand are the key molecules for antigen receptor-induced apoptosis in activated mature T cells. Here we propose a mechanism for antigen receptor-induced apoptosis of activated T cells via APO-1 ligand mediated autocrine suicide. This mechanism may also contribute to the depletion of CD4+ T cells in AIDS.
authors.affiliation: Tumorimmunology Program, German Cancer Research Center, Heidelberg.
authors.forename: J
authors.initials: J
authors.lastname: Dhein
authors.forename: H
authors.initials: H
authors.lastname: Walczak
authors.forename: M O
authors.initials: MO
authors.lastname: Westendorp
authors.forename: C
authors.initials: C
authors.lastname: Bäumler
authors.forename: K
authors.initials: K
authors.lastname: Stricker
authors.forename: R
authors.initials: R
authors.lastname: Frank
authors.forename: K M
authors.initials: KM
authors.lastname: Debatin
authors.forename: P H
authors.initials: PH
authors.lastname: Krammer
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D000818:Animals; D015703:Antigens, CD / Q000235:genetics / Q000276:immunology / Q000502:physiology*; D017209:Apoptosis; D001327:Autoimmune Diseases / Q000235:genetics / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance; D018448:Models, Immunological; D009154:Mutation; D017475:Receptors, Nerve Growth Factor / Q000502:physiology; D018124:Receptors, Tumor Necrosis Factor / Q000502:physiology; D013601:T-Lymphocytes / Q000276:immunology*; D019014:fas Receptor / Q000235:genetics / Q000276:immunology / Q000502:physiology*
chemical_list: D015703:Antigens, CD; D017475:Receptors, Nerve Growth Factor; D018124:Receptors, Tumor Necrosis Factor; D019014:fas Receptor