Transtympanic gentamycin in the treatment of Ménière's disease.
Severe cases of Ménière's disease are successfully treated with ototoxic antibiotics. Gentamycin sulphate gives the best results. With the aid of a small syringe the drug is introduced into the external auditory canal 3-5 times per day. From there it is transported into the middle ear through a ventilating tube (Grommet) under slight pressure (Politzer bag). The liquid then penetrates the round and oval windows and influences inner-ear function. More than 90% of our patients in 25 years after therapy had no further attacks.
Lange
G
G
HNO Klinik, Universistat Witten/Herdecke, Wuppertal, Germany.
D004432:Ear, Middle; D005839:Gentamicins / Q000008:administration & dosage* / Q000627:therapeutic use; D006801:Humans; D007322:Instillation, Drug; D008575:Meniere Disease / Q000188:drug therapy*
D005839:Gentamicins