Effects of the competitive NMDA receptor antagonist CGP 37849 on performance of reference and working memory tasks by rats.
The effects of the competitive NMDA receptor antagonist CGP 37849 (DL-(E)-2-amino-4-methyl-5-phosphono-3-pentenoic acid) were tested in rats performing (1) a nonspatial working memory task, and (2) a reference memory task that was either partly or fully learnt. CGP 37849 attenuated accuracy in all three tests, suggesting that sensorimotor effects may obscure any drug effects on memory itself.
Deacon
R M
RM
Department of Experimental Psychology, University of Oxford, UK.
Rawlins
J N
JN
D015763:2-Amino-5-phosphonovalerate / Q000031:analogs & derivatives* / Q000494:pharmacology; D000818:Animals; D004192:Discrimination, Psychological / Q000187:drug effects; D018691:Excitatory Amino Acid Antagonists / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D008568:Memory / Q000187:drug effects; D008570:Memory, Short-Term / Q000187:drug effects*; D011597:Psychomotor Performance / Q000187:drug effects*; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors*
D018691:Excitatory Amino Acid Antagonists; D016194:Receptors, N-Methyl-D-Aspartate; C064539:2-amino-4-methyl-5-phosphono-3-pentenoic acid; D015763:2-Amino-5-phosphonovalerate