title: The minimal gene complement of Mycoplasma genitalium.
abstract: The complete nucleotide sequence (580,070 base pairs) of the Mycoplasma genitalium genome, the smallest known genome of any free-living organism, has been determined by whole-genome random sequencing and assembly. A total of only 470 predicted coding regions were identified that include genes required for DNA replication, transcription and translation, DNA repair, cellular transport, and energy metabolism. Comparison of this genome to that of Haemophilus influenzae suggests that differences in genome content are reflected as profound differences in physiology and metabolic capacity between these two organisms.
authors.affiliation: Institute for Genomic Research, Rockville, MD 20850, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Fraser
authors.forename: J D
authors.initials: JD
authors.lastname: Gocayne
authors.forename: O
authors.initials: O
authors.lastname: White
authors.forename: M D
authors.initials: MD
authors.lastname: Adams
authors.forename: R A
authors.initials: RA
authors.lastname: Clayton
authors.forename: R D
authors.initials: RD
authors.lastname: Fleischmann
authors.forename: C J
authors.initials: CJ
authors.lastname: Bult
authors.forename: A R
authors.initials: AR
authors.lastname: Kerlavage
authors.forename: G
authors.initials: G
authors.lastname: Sutton
authors.forename: J M
authors.initials: JM
authors.lastname: Kelley
authors.forename: R D
authors.initials: RD
authors.lastname: Fritchman
authors.forename: J F
authors.initials: JF
authors.lastname: Weidman
authors.forename: K V
authors.initials: KV
authors.lastname: Small
authors.forename: M
authors.initials: M
authors.lastname: Sandusky
authors.forename: J
authors.initials: J
authors.lastname: Fuhrmann
authors.forename: D
authors.initials: D
authors.lastname: Nguyen
authors.forename: T R
authors.initials: TR
authors.lastname: Utterback
authors.forename: D M
authors.initials: DM
authors.lastname: Saudek
authors.forename: C A
authors.initials: CA
authors.lastname: Phillips
authors.forename: J M
authors.initials: JM
authors.lastname: Merrick
authors.forename: J F
authors.initials: JF
authors.lastname: Tomb
authors.forename: B A
authors.initials: BA
authors.lastname: Dougherty
authors.forename: K F
authors.initials: KF
authors.lastname: Bott
authors.forename: P C
authors.initials: PC
authors.lastname: Hu
authors.forename: T S
authors.initials: TS
authors.lastname: Lucier
authors.forename: S N
authors.initials: SN
authors.lastname: Peterson
authors.forename: H O
authors.initials: HO
authors.lastname: Smith
authors.forename: C A
authors.initials: CA
authors.lastname: Hutchison
authors.forename: J C
authors.initials: JC
authors.lastname: Venter
mesh_terms: D000940:Antigenic Variation / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics; D001692:Biological Transport / Q000235:genetics; D004260:DNA Repair / Q000235:genetics; D004261:DNA Replication / Q000235:genetics; D004269:DNA, Bacterial / Q000235:genetics; D016208:Databases, Factual; D004734:Energy Metabolism / Q000235:genetics; D005798:Genes, Bacterial; D016680:Genome, Bacterial; D006193:Haemophilus influenzae / Q000235:genetics; D008969:Molecular Sequence Data; D009174:Mycoplasma / Q000235:genetics* / Q000276:immunology / Q000378:metabolism; D016366:Open Reading Frames; D014176:Protein Biosynthesis; D017422:Sequence Analysis, DNA; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D004269:DNA, Bacterial