title: Computer prediction and experimental validation of cytochrome P4502D6-dependent oxidation of GBR 12909.
authors.affiliation: Department of Pharmacochemistry, Amsterdam, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: de Groot
authors.forename: G J
authors.initials: GJ
authors.lastname: Bijloo
authors.forename: K T
authors.initials: KT
authors.lastname: Hansen
authors.forename: N P
authors.initials: NP
authors.lastname: Vermeulen
mesh_terms: D003198:Computer Simulation; D019389:Cytochrome P-450 CYP2D6; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D018765:Dopamine Uptake Inhibitors / Q000378:metabolism*; D006899:Mixed Function Oxygenases / Q000378:metabolism*; D010084:Oxidation-Reduction; D010879:Piperazines / Q000378:metabolism*; D011237:Predictive Value of Tests; D015203:Reproducibility of Results; D013329:Structure-Activity Relationship
chemical_list: D018765:Dopamine Uptake Inhibitors; D010879:Piperazines; D003577:Cytochrome P-450 Enzyme System; C043425:vanoxerine; D006899:Mixed Function Oxygenases; D019389:Cytochrome P-450 CYP2D6