Serum lipid and glucose concentrations with a propofol infusion for cardiac surgery.
OBJECTIVE
To document changes in serum lipids and glucose with a propofol infusion technique for cardiac surgery.


METHODS
Prospective cohort.


METHODS
University teaching hospital.


METHODS
22 elective cardiac surgical patients.


METHODS
Frequent venous blood sampling.


RESULTS
Serum lipids and glucose were measured at 10 time periods perioperatively, from preinduction until 4 hours post-cardiopulmonary bypass. Plasma propofol concentrations were also measured in 10 of these patients. There was a significant increase in glucose (P < 0.0005) and decreases in cholesterol (P < 0.0005), high-density lipoprotein (P = 0.004), and low-density lipoprotein (P < 0.0005); there was no significant change in triglycerides (P = 0.39). The propofol infusion resulted in acceptable plasma levels throughout the procedure and allowed early extubation in the intensive care unit, after a mean (SD) of 7.14 (5.9) hours. There was a strong correlation between triglyceride and propofol levels at most time periods (r = 0.38 to 0.98).


CONCLUSIONS
This study demonstrates that a propofol infusion technique does not result in elevation of serum lipids and supports its increased popularity in maintenance of anesthesia for cardiac surgery.
Myles
P S
PS
Department of Anaesthesia, Alfred Hospital, Monash University, Australia.
Buckland
M R
MR
Morgan
D J
DJ
Weeks
A M
AM
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000771:Anesthesia, Intravenous; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000097:blood; D001786:Blood Glucose / Q000032:analysis* / Q000187:drug effects; D006348:Cardiac Surgical Procedures; D002315:Cardiopulmonary Bypass; D002784:Cholesterol / Q000097:blood; D008076:Cholesterol, HDL / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D015331:Cohort Studies; D003422:Critical Care; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007442:Intubation, Intratracheal; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015742:Propofol / Q000008:administration & dosage* / Q000097:blood; D011446:Prospective Studies; D014280:Triglycerides / Q000097:blood
D018686:Anesthetics, Intravenous; D001786:Blood Glucose; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D008055:Lipids; D014280:Triglycerides; D002784:Cholesterol; D015742:Propofol