title: Peripheral T-cell lymphoma in a chronically immunosuppressed renal transplant patient.
abstract: Non-Hodgkin large cell lymphomas occurs more commonly in organ-transplanted patients than in the general population. They are usually of B-cell origin whereas T-cell lymphomas are rare. We report a new case of peripheral T-cell lymphoma in an immunosuppressed renal transplanted patient. The patient presented a hepatosplenic mass with a widespread extension causing serious pancytopenia. It was classified as a pleomorphic medium and large cell type and corresponded to the "common" alpha beta-TCR type lymphoma. Lymphomatous cells exhibited an incomplete mature T-cell phenotype. T-cell receptor gene clonal rearrangement associated with a germline configuration of the immunoglobulin heavy chain gene confirmed a clonal T-cell genotype. By using both Southern blot analysis and polymerase chain reaction, we failed to demonstrate any association with Epstein-Barr virus or human T-cell lymphotropic virus type I or type II.
authors.affiliation: Laboratoire d'Anatomie Pathologique, Hôpital Haut-Lévêque, Pessac, France.
authors.forename: E
authors.initials: E
authors.lastname: Labouyrie
authors.forename: D
authors.initials: D
authors.lastname: Morel
authors.forename: J M
authors.initials: JM
authors.lastname: Boiron
authors.forename: P
authors.initials: P
authors.lastname: Dubus
authors.forename: M
authors.initials: M
authors.lastname: Montastruc
authors.forename: B
authors.initials: B
authors.lastname: Bloch
authors.forename: J
authors.initials: J
authors.lastname: Reiffers
authors.forename: A
authors.initials: A
authors.lastname: de Mascarel
authors.forename: J P
authors.initials: JP
authors.lastname: Merlio
mesh_terms: D000328:Adult; D001483:Base Sequence; D001853:Bone Marrow / Q000473:pathology; D006801:Humans; D016130:Immunophenotyping; D007165:Immunosuppression Therapy / Q000009:adverse effects*; D016030:Kidney Transplantation / Q000009:adverse effects*; D016411:Lymphoma, T-Cell, Peripheral / Q000209:etiology / Q000473:pathology*; D008297:Male; D008969:Molecular Sequence Data