title: Describing multiple levels of abstraction in the metabolism.
abstract: We discuss some central issues that arise in the computer representation of the metabolism and its subsystems. We provide a framework for the representation of metabolites and bioreactions at multiple levels of detail. The framework is based on defining an explicit linear mapping of metabolites and reactions from one level of detail to another. A simple reaction mechanism serves as an illustration and shows the emergence of the concept of a catalyst from metabolic abstraction levels.
authors.affiliation: Department of Chemical Engineering, Northwestern University, Evanston, IL 60208-3120, USA.
authors.forename: M L
authors.initials: ML
authors.lastname: Mavrovouniotis
mesh_terms: D002384:Catalysis; D003198:Computer Simulation; D008660:Metabolism