Immunoreactivity of ageing C57BL female mice rendered tolerant to the H-Y antigen.
Transplantation tolerance to the H-Y antigen, induced in neonatal or young adult C57BL female mice, beneficially affected their immunoreactivity during the process of ageing. The tolerance acquired in 2-month-old females significantly increased their splenocyte graft-versus-host (GVH) reactivity and the production of interleukin-2 (IL-2) at the age of 18 months. The neonatally induced tolerance also resulted in a higher weight of the thymus and a significantly enhanced GVH reactivity of thymocytes in 18-month-old females compared to control mice of the same age.
Skowron-Cendrzak
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A
Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Roman
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Holán
V
V
Kubera
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M
Basta-Kaim
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D000375:Aging / Q000276:immunology*; D000818:Animals; D000831:Animals, Newborn; D005260:Female; D006087:Graft vs Host Reaction; D006182:H-Y Antigen / Q000276:immunology*; D007108:Immune Tolerance; D007165:Immunosuppression Therapy; D007376:Interleukin-2 / Q000096:biosynthesis; D017710:Lymphocyte Transfusion; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009929:Organ Size; D013154:Spleen / Q000033:anatomy & histology / Q000254:growth & development / Q000637:transplantation; D013950:Thymus Gland / Q000033:anatomy & histology / Q000254:growth & development; D014185:Transplantation, Isogeneic
D006182:H-Y Antigen; D007376:Interleukin-2