title: Purified Pseudomonas aeruginosa PA-I lectin induces gut growth when orally ingested by rats.
abstract: The effects of PA-I lectin isolated from the human pathogen Pseudomonas aeruginosa upon cellular metabolism in vivo have been studied using the rat gut as a model system. Orally ingested PA-I lectin stimulated metabolic activity and induced polyamine accumulation and growth in the small intestine, caecum and colon. The nature and extent of the changes induced by PA-I lectin were similar to those caused by dietary kidney bean lectin and were likely to lead to impaired epithelial cell function and integrity. This finding contributes to our understanding of the possible roles of these lectins in Pseudomonas aeruginosa infection.
authors.affiliation: Rowett Research Institute, Bucksburn, Aberdeen, UK.
authors.forename: G
authors.initials: G
authors.lastname: Grant
authors.forename: S
authors.initials: S
authors.lastname: Bardocz
authors.forename: S W
authors.initials: SW
authors.lastname: Ewen
authors.forename: D S
authors.initials: DS
authors.lastname: Brown
authors.forename: T J
authors.initials: TJ
authors.lastname: Duguid
authors.forename: A
authors.initials: A
authors.lastname: Pusztai
authors.forename: D
authors.initials: D
authors.lastname: Avichezer
authors.forename: D
authors.initials: D
authors.lastname: Sudakevitz
authors.forename: A
authors.initials: A
authors.lastname: Belz
authors.forename: N C
authors.initials: NC
authors.lastname: Garber
mesh_terms: D018829:Adhesins, Bacterial / Q000008:administration & dosage / Q000633:toxicity*; D000284:Administration, Oral; D000818:Animals; D004247:DNA / Q000378:metabolism; D006801:Humans; D007413:Intestinal Mucosa / Q000378:metabolism; D007422:Intestines / Q000187:drug effects* / Q000254:growth & development; D037102:Lectins / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D010835:Phytohemagglutinins / Q000633:toxicity; D011073:Polyamines / Q000378:metabolism; D011506:Proteins / Q000378:metabolism; D011552:Pseudomonas Infections / Q000209:etiology; D011550:Pseudomonas aeruginosa / Q000472:pathogenicity*; D012313:RNA / Q000378:metabolism; D051381:Rats
chemical_list: D018829:Adhesins, Bacterial; D037102:Lectins; D010835:Phytohemagglutinins; D011073:Polyamines; D011506:Proteins; C038692:adhesin, Pseudomonas; D012313:RNA; D004247:DNA