Presence of virion protein x (Vpx) of simian immunodeficiency virus SIVmac 251 in target cells in vivo.
Localization of virion-associated protein x (Vpx) of SIVmac 251 was studied in lymph nodes and liver of six SIVmac-infected monkeys. Vpx was found associated with the network of follicular dendritic cells and macrophages in lymph nodes and/or livers from five out of six animals by immunohistochemistry. Although the humoral response to Vpx occurs in only 50% of the animals, the presence of Vpx in target cell or antibodies to Vpx in all the monkeys studied, suggests that Vpx may be necessary for viral replication in vivo.
Persidsky
Y
Y
Unité INSERM 74, Institut de Virologie de la Faculté de Médecine, Université Louis Pasteur, Strasbourg, France.
Liska
V
V
Huss
T
T
Gendrault
J L
JL
Venet
A
A
Muchmore
E
E
Traincard
F
F
Kirn
A
A
Aubertin
A M
AM
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D007150:Immunohistochemistry; D007728:Kupffer Cells / Q000821:virology; D008099:Liver / Q000821:virology*; D008198:Lymph Nodes / Q000821:virology*; D008253:Macaca mulatta; D008264:Macrophages / Q000821:virology; D008297:Male; D016097:Simian Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology / Q000821:virology*; D015302:Simian Immunodeficiency Virus / Q000276:immunology / Q000302:isolation & purification / Q000502:physiology*; D013997:Time Factors; D054334:Viral Regulatory and Accessory Proteins / Q000032:analysis*; D014779:Virus Replication
D000914:Antibodies, Viral; C513059:VPX protein, Simian immunodeficiency virus; D054334:Viral Regulatory and Accessory Proteins