title: [Thermodynamic parameters of complex formation of blood plasma fibronectin and myeloperoxidase].
abstract: Previous studies have demonstrated that fibronectin immobilized on BrCN-activated agarose forms a complex with soluble myeloperoxidase. The affinity of such interaction increases after preliminary absorption of fibronectin on a column with immobilized gelatin, one of its natural ligands. The thermodynamic characteristics of the myeloperoxidase interaction with fibronectin-gelatin-agarose have been established. The role of fibronectin-myeloperoxidase interaction in the inflammation focus is discussed in terms of the mode of the phagocyte loading with the enzyme and as a way of protecting intrinsic body tissues from injury by oxidants generated by extracellular myeloperoxidase.
authors.forename: O Iu
authors.initials: OIu
authors.lastname: Iankovskiĭ
authors.forename: L R
authors.initials: LR
authors.lastname: Khilazhetdinova
authors.forename: V N
authors.initials: VN
authors.lastname: Kokriakov
authors.forename: G M
authors.initials: GM
authors.lastname: Aleshina
authors.forename: I A
authors.initials: IA
authors.lastname: Iablunovskaia
authors.forename: G M
authors.initials: GM
authors.lastname: Podsukhina
authors.forename: Iu V
authors.initials: IuV
authors.lastname: Gavrilova
authors.forename: N V
authors.initials: NV
authors.lastname: Leonova
mesh_terms: D002846:Chromatography, Affinity; D005353:Fibronectins / Q000097:blood*; D005780:Gelatin / Q000737:chemistry; D009195:Peroxidase / Q000097:blood*; D010586:Phagocytes / Q000201:enzymology; D012685:Sepharose / Q000737:chemistry; D013696:Temperature; D013816:Thermodynamics
chemical_list: D005353:Fibronectins; D005780:Gelatin; D012685:Sepharose; D009195:Peroxidase
vernacular_title: Termodinmicheskie parametry kompleksoobrazovaniia fibronektina plazmy krovi i mieloperoksidazy.