Autoimmunity, apoptosis defects and retroviruses.
Autoimmunity and AIDS both share the common feature of increased expression of retroviral protein products and abnormal apoptosis of immune cells (81). This leads to a more global immunomodulatory defect (82-84). The challenge in the future will be to devise compounds that can either regulate the effect of the retroviral products on apoptosis, or that can inhibit apoptosis pathways in order to restore normal immune system function.
Mountz
J D
JD
University of Alabama, Department of Medicine, Birmingham, USA.
Cheng
J
J
Su
X
X
Wu
J
J
Zhou
T
T
D000595:Amino Acid Sequence; D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D015551:Autoimmunity; D001483:Base Sequence; D006801:Humans; D051379:Mice; D008969:Molecular Sequence Data; D017354:Point Mutation; D018626:Retroelements; D012190:Retroviridae / Q000276:immunology*; D019014:fas Receptor
D018626:Retroelements; D019014:fas Receptor