Adrenal medullary grafts suppress c-fos induction in spinal neurons of arthritic rats.
Expression of immediate-early genes such as c-fos is thought to reflect patterns of neuronal activity in the central nervous system. Prolonged increases in Fos-protein-like-immunoreactivity (FOS-LI) are seen in the dorsal horn of adjuvant arthritic rats, and parallel increased pain behavior. Grafts of adrenal medullary, but not control tissue, into the spinal subarachnoid space reduce pain behavior and suppress the induction of spinal Fos-LI in arthritic rats. This reduction is particularly marked in superficial laminae (I-II), but is also significant in deeper laminae (III-IV and V-VI). The results of this study suggest that adrenal medullary transplants reduce spinal cord hyperactivation consequent to painful peripheral inflammation.
Sagen
J
J
Department of Anatomy and Cell Biology, University of Illinois at Chicago 60612, USA.
Wang
H
H
D000313:Adrenal Medulla / Q000637:transplantation*; D000818:Animals; D001169:Arthritis, Experimental / Q000235:genetics*; D004195:Disease Models, Animal; D015870:Gene Expression / Q000502:physiology; D016762:Genes, fos / Q000502:physiology*; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000737:chemistry / Q000502:physiology*; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000166:cytology* / Q000502:physiology
D016760:Proto-Oncogene Proteins c-fos