Progress in Alzheimer's disease genetics.
Three genetic loci for Alzheimer's disease have been identified. These are the amyloid precursor gene on chromosome 21, a gene for early-onset autosomal dominant Alzheimer's disease on chromosome 14, and the risk-modifying gene APOE on chromosome 19. Additional Alzheimer's disease genes remain to be found. The genes identified by studying inherited forms of Alzheimer's disease are now being used to understand the initiating steps in the pathogenesis of the disease.
Schellenberg
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Geriatric Research, Education and Clinical Center, Seattle Veterans Affairs Medical Center, Washington, USA.
D000368:Aged; D000544:Alzheimer Disease / Q000235:genetics*; D016564:Amyloid beta-Protein Precursor / Q000235:genetics; D001057:Apolipoproteins E / Q000235:genetics; D002869:Chromosome Aberrations / Q000235:genetics; D025063:Chromosome Disorders; D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D002888:Chromosomes, Human, Pair 19; D002891:Chromosomes, Human, Pair 21; D005799:Genes, Dominant / Q000235:genetics; D005819:Genetic Markers / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D010641:Phenotype
D016564:Amyloid beta-Protein Precursor; D001057:Apolipoproteins E; D005819:Genetic Markers