title: Sarcoidosis patients have bronchial hyperreactivity and signs of mast cell activation in their bronchoalveolar lavage.
abstract: An increased (p < 0.001) frequency of bronchial hyperreactivity (BHR) was found in sarcoidosis patients as compared with healthy volunteers. The patients had more mast cells (p < 0.001) and tryptase (p < 0.001) in their bronchoalveolar lavage fluid, but there were no differences between BHR-positive and BHR-negative patients. Furthermore, the bronchoalveolar lavage fluid concentrations of macrophages, lymphocytes, and of the soluble components albumin, fibronectin, and vitronectin were also elevated in the sarcoidosis patients, indicating an ongoing inflammation in the airways and/or in the interstitium. We observed no significant differences in the parameters when the sarcoidosis patients were subdivided into BHR, clinical activity, or chest X-ray stages. Our findings may indicate a multifactorial background to the hyperreactivity.
authors.affiliation: Department of Medicine, Karolinska Hospital, Stockholm, Sweden.
authors.forename: M B
authors.initials: MB
authors.lastname: Ohrn
authors.forename: C M
authors.initials: CM
authors.lastname: Sköld
authors.forename: M
authors.initials: M
authors.lastname: van Hage-Hamsten
authors.forename: O
authors.initials: O
authors.lastname: Sigurdardottir
authors.forename: O
authors.initials: O
authors.lastname: Zetterström
authors.forename: A
authors.initials: A
authors.lastname: Eklund
mesh_terms: D000293:Adolescent; D000328:Adult; D016535:Bronchial Hyperreactivity / Q000209:etiology*; D001992:Bronchoalveolar Lavage Fluid / Q000276:immunology*; D002452:Cell Count; D053818:Chymases; D016326:Extracellular Matrix Proteins / Q000032:analysis; D005260:Female; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D006820:Hyaluronic Acid / Q000032:analysis; D007249:Inflammation / Q000378:metabolism; D018836:Inflammation Mediators / Q000378:metabolism; D016676:Macrophages, Alveolar / Q000166:cytology; D008297:Male; D008407:Mast Cells / Q000201:enzymology / Q000276:immunology*; D008875:Middle Aged; D017565:Sarcoidosis, Pulmonary / Q000150:complications / Q000276:immunology* / Q000473:pathology; D012697:Serine Endopeptidases / Q000378:metabolism; D053802:Tryptases
chemical_list: D016326:Extracellular Matrix Proteins; D018836:Inflammation Mediators; D006632:Histamine; D006820:Hyaluronic Acid; D012697:Serine Endopeptidases; C083294:chymase 2; D053818:Chymases; D053802:Tryptases