Colocalization of the rat homolog of the von Hippel Lindau (Vhl) gene and the plasma membrane Ca++ transporting ATPase isoform 2 (Atp2b2) gene to rat chromosome bands 4q41.3-->42.1.
Using fluorescence in situ hybridization, we localized the rat homolog of the von Hippel-Lindau gene (Vhl) to rat chromosome band 4q41.3-->q42.1. We also mapped the gene encoding the plasma membrane Ca(++)-transporting ATPase isoform 2(Atp2b2) to the same chromosome subregion. These two genes together with Raf1 appear to be members of a large syntenic gene cluster that maps to human chromosome bands 3p25-->p26, mouse chromosome bands 6 C3-->E, and rat chromosome bands 4q41-->q42. Cytogenetic analysis of NRK 52E cells derived from immortalized normal rat kidney epithelial cells revealed an inverted duplication of the region containing this gene cluster.
Aldaz
C M
CM
University of Texas M.D. Anderson Cancer Center, Department of Carcinogenesis, Smithville 78957, USA.
Yeung
R S
RS
Latif
F
F
Lerman
M I
MI
Xiao
G
G
Trono
D
D
Walker
C L
CL
D000818:Animals; D000252:Calcium-Transporting ATPases / Q000235:genetics*; D002461:Cell Line, Transformed; D002462:Cell Membrane / Q000201:enzymology; D002871:Chromosome Banding; D002874:Chromosome Mapping; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008025:Ligases; D051379:Mice; D009687:Nuclear Proteins / Q000235:genetics*; D051381:Rats; D025521:Tumor Suppressor Proteins; D044767:Ubiquitin-Protein Ligases; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D006623:von Hippel-Lindau Disease / Q000235:genetics*
D009687:Nuclear Proteins; D025521:Tumor Suppressor Proteins; D044767:Ubiquitin-Protein Ligases; D051794:Von Hippel-Lindau Tumor Suppressor Protein; D008025:Ligases; C497446:VHL protein, human; D000252:Calcium-Transporting ATPases