[Acute pancreatitis associated with hepatotoxicity induced by amoxicillin-clavulanic acid].
A 25-year old man suffered from acute pancreatitis and cholestatic acute hepatitis simultaneously after 4 weeks of an antibiotic treatment withdrawal (amoxicillin plus clavulanic acid) which was given for pharyngitis. Other potential etiological causes of both acute pancreatitis and liver disease, were excluded. The causal relationship between amoxicillin plus clavulanic acid and cholestatic hepatitis is well know, but no data has been reported regarding acute pancreatitis. The medical literature is reviewed and the mechanisms of toxicity are discussed.
Galindo
C
C
Sección Digestivo, Hospital Arnau de Vilanova, Facultad de Medicina, Lleida.
Buenestado
J
J
Reñé
J M
JM
Piñol
M C
MC
D000208:Acute Disease; D000328:Adult; D000658:Amoxicillin / Q000009:adverse effects*; D000900:Anti-Bacterial Agents / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000150:complications*; D019818:Clavulanic Acid; D002969:Clavulanic Acids / Q000009:adverse effects*; D004359:Drug Therapy, Combination; D006801:Humans; D008297:Male; D010195:Pancreatitis / Q000139:chemically induced*; D010406:Penicillins / Q000009:adverse effects*
D000900:Anti-Bacterial Agents; D002969:Clavulanic Acids; D010406:Penicillins; D019818:Clavulanic Acid; D000658:Amoxicillin
Pancreatitis aguda asociada a hepatotoxicidad por amoxicilina-clavulánico.