A Bayesian approach to drug disposition evaluation: application to teicoplanin.
We suggest a Bayesian method in order to evaluate the disposition kinetics of the drug plasma concentrations after intravenous (i.v.) and/or after extravascular administration of the drug in the same subject pooled with information obtained taking into account previous pharmacokinetics of the drug. This approach was applied to the investigation of teicoplanin pharmacokinetics after 200 mg i.v. administration to 10 healthy subjects.
Ferrante
L
L
Institute of Biomedical Sciences, Faculty of Medicine, University of Ancona, Italy.
Bompadre
S
S
Cingolani
M L
ML
Leone
L
L
D000328:Adult; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D001499:Bayes Theorem; D001681:Biological Assay; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D017334:Teicoplanin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D014018:Tissue Distribution
D000900:Anti-Bacterial Agents; D017334:Teicoplanin