title: Human renin 5'-flanking DNA to nucleotide-2750.
abstract: Renin is one of the most important factors in blood pressure and electrolyte regulation in mammals and the renin locus has been implicated in hypertension. To assist studies of promoter control we therefore determined the 5'-flanking sequence of the human gene (REN) to residue -2750 relative to the transcription start site (+1). Sites of homology to consensus sequences for binding of trans-acting factors involved in transcriptional control of other genes were identified, and functionality for two of these (a CRE and Pit-1 site) have so far been demonstrated.
authors.affiliation: Department of Physiology, University of Sydney, NSW, Australia.
authors.forename: D L
authors.initials: DL
authors.lastname: Smith
authors.forename: S
authors.initials: S
authors.lastname: Jeyapalan
authors.forename: J A
authors.initials: JA
authors.lastname: Lang
authors.forename: X H
authors.initials: XH
authors.lastname: Guo
authors.forename: C D
authors.initials: CD
authors.lastname: Sigmund
authors.forename: B J
authors.initials: BJ
authors.lastname: Morris
mesh_terms: D001483:Base Sequence; D016384:Consensus Sequence; D015698:Genomic Library; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic; D012045:Regulatory Sequences, Nucleic Acid; D012083:Renin / Q000235:genetics*; D017422:Sequence Analysis, DNA
chemical_list: D012083:Renin