[Behavior of endothelin plasma levels during iloprost infusion in patients with severe ischemia in the lower extremities].
In order to clarify interactions between the various endothelial vasoactive substances, the authors studied the behaviour of endothelin plasma levels during acute iloprost infusion in 7 elderly patients with critical leg ischemia. Iloprost was administered i.v., diluted in saline solution (200 ng/ml, from 30 to 40 ml/h, for 6 hours/day over 4 weeks). Endothelin was assayed in plasma on day 4 of treatment at times 0, 2, 4, 6, 8, hours, or in other words before treatment and ten every 2 hours up until the 6th hour, and then 2 hours after the end of iloprost infusion. The control group consisted of 7 age-matched subjects suffering from peripheral obliterating arterial disease at Fontaine's stage 1 and 2 who where infused with saline solution alone. Patients receiving iloprost presented a mean endothelin plasma level +/- SD at time 0 of 5.40 +/- 1.23 pg/ml, 4.24 +/- 0.72 pg/ml at time 2, 4.22 +/- 0.74 pg/ml at time 4, 4.24 +/- 0.22 pg/ml at time 6, and 4.49 +/- 0.58 pg/ml at time 8. The difference between endothelin levels in basal conditions and those at time 2, 4 and 6 was statistically significant. The difference between the peptide at times 0 and 8 was not statistically significant. In the control group the mean +/- SD of endothelin plasma level was, at the same times, respectively 5.23 +/- 0.55 pg/ml, 4.88 +/- 1.39 pg/ml, 5.44 +/- 1.51 pg/ml, 5.10 +/- 0.86 pg/ml and 5.60 +/- 1.64 pg/ml. The difference between endothelin levels in basal conditions and those at later times was not statistically significant.(ABSTRACT TRUNCATED AT 250 WORDS)
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Istituto di Semeiotica e Medica e Geriatria, Università degli Studi, Siena.
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D000368:Aged; D000369:Aged, 80 and over; D000375:Aging; D001162:Arteriosclerosis Obliterans; D016232:Endothelins / Q000097:blood*; D005260:Female; D006801:Humans; D016285:Iloprost / Q000008:administration & dosage* / Q000494:pharmacology; D007262:Infusions, Intravenous; D007511:Ischemia / Q000188:drug therapy*; D007866:Leg / Q000098:blood supply*; D008297:Male; D014665:Vasodilator Agents / Q000008:administration & dosage* / Q000494:pharmacology
D016232:Endothelins; D014665:Vasodilator Agents; D016285:Iloprost
Comportamento dei livelli plasmatici di endotelina durante infusione di iloprost in pazienti affetti da ischemia critica degli arti inferiori.