title: Fatal necrotizing pancreatitis caused by hepatitis B virus infection in a liver transplant recipient.
abstract: A 32-year-old man who had undergone liver transplantation for fulminant hepatitis due to HBV infection developed fatal acute necrotizing pancreatitis on the 60th post-transplant day, while showing signs of intense viral replication. Immunohistochemistry and in situ hybridization of the pancreas following autopsy showed the presence of HBsAG and HBV-DNA in the cytoplasm of acinar cells, together with the picture of necrotizing pancreatitis. Clinical and histological features seem to indicate that pancreatitis was directly caused by HBV infection.
authors.affiliation: Second Department of Surgery, University of Bologna, S. Orsola Hospital, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Cavallari
authors.forename: M
authors.initials: M
authors.lastname: Vivarelli
authors.forename: A
authors.initials: A
authors.lastname: D'Errico
authors.forename: R
authors.initials: R
authors.lastname: Bellusci
authors.forename: P
authors.initials: P
authors.lastname: Scarani
authors.forename: E
authors.initials: E
authors.lastname: DeRaffele
authors.forename: B
authors.initials: B
authors.lastname: Nardo
authors.forename: G
authors.initials: G
authors.lastname: Gozzetti
mesh_terms: D000208:Acute Disease; D000328:Adult; D017809:Fatal Outcome; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy / Q000821:virology; D006801:Humans; D016031:Liver Transplantation / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D009336:Necrosis; D010195:Pancreatitis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D011859:Radiography