title: The influence of the design of two different bioresorbable barriers on the results of guided tissue regeneration therapy. An intra-individual comparative study in the monkey.
abstract: The aim of the present study was to compare two bioresorbable barriers to evaluate whether differences in design influence the result of guided tissue regeneration (GTR) therapy. Twenty-four (24) plaque exposed, recession type defects in 4 monkeys were treated. Contralateral defects were randomized for test or control treatment. During a healing period of 6 weeks, gingival recession resulting in device exposure occurred at 3 test and 10 control sites. One control barrier was exfoliated. Histologically, 9 of the 12 test barriers were completely integrated with the surrounding tissues. At 3 test sites, epithelium had migrated apically outside the barrier to a level not exceeding one-third of the height of the device. Seven of the 11 control barriers were enclosed by dentogingival epithelium. The adjacent connective tissue exhibited local inflammatory cell infiltrates (ICT). At the remaining 4 control sites, the epithelial downgrowth as well as the adjacent ICT areas were limited to the coronal 1/3 of the device. New attachment; i.e., new cementum with inserting collagen fibers, averaged 2.2 mm and 0.8 mm at the test and control sites respectively (P < 0.01). Based on the results of the present study, it was concluded that a bioresorbable GTR device, designed to prevent epithelial downgrowth along the barrier surface, has a higher potential to promote new attachment formation than a device which does not have this property.
authors.affiliation: Institute for Postgraduate Dental Education, Jönköping, Sweden.
authors.forename: D
authors.initials: D
authors.lastname: Lundgren
authors.forename: L
authors.initials: L
authors.lastname: Laurell
authors.forename: J
authors.initials: J
authors.lastname: Gottlow
authors.forename: H
authors.initials: H
authors.lastname: Rylander
authors.forename: T
authors.initials: T
authors.lastname: Mathisen
authors.forename: S
authors.initials: S
authors.lastname: Nyman
authors.forename: M
authors.initials: M
authors.lastname: Rask
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001673:Biodegradation, Environmental; D003094:Collagen; D003238:Connective Tissue / Q000473:pathology; D003739:Dental Cementum / Q000473:pathology; D003773:Dental Plaque / Q000473:pathology; D004846:Epithelial Attachment / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D004867:Equipment Design; D004868:Equipment Failure; D017823:Furcation Defects / Q000473:pathology / Q000601:surgery*; D005881:Gingiva / Q000473:pathology; D005889:Gingival Recession / Q000473:pathology; D016557:Guided Tissue Regeneration, Periodontal; D007249:Inflammation; D007773:Lactates; D019344:Lactic Acid; D008252:Macaca fascicularis; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D014945:Wound Healing
chemical_list: D001672:Biocompatible Materials; D007773:Lactates; D008567:Membranes, Artificial; D011091:Polyesters; D011108:Polymers; D019344:Lactic Acid; C033616:poly(lactide); D003094:Collagen