Changes in serum carboxyterminal telopeptide of type I collagen in an experimental model of canine osteomyelitis.
Blood biochemical indices of bone turnover were followed up for 1 month in six dogs with experimental osteomyelitis. The bone infection resulted in significant increase in parameters of bone formation (serum bone alkaline phosphatase and serum osteocalcin) and bone resorption [serum carboxyterminal telopeptide of type I collagen (i-ICTP)] as early as the end of the second week after the operation and inoculation. There was strong evidence that serum i-ICTP levels could be useful for the early diagnosis of postoperative complications in veterinary orthopedics, such as posttraumatic osteomyelitis.
Philipov
J P
JP
Department of Surgery, Faculty of Veterinary Medicine, Stara Zagora, Bulgaria.
Pascalev
M D
MD
Aminkov
B Y
BY
Grosev
C D
CD
D000469:Alkaline Phosphatase / Q000097:blood*; D000818:Animals; D015415:Biomarkers / Q000097:blood; D001846:Bone Development; D001862:Bone Resorption; D003094:Collagen / Q000097:blood*; D024042:Collagen Type I; D004283:Dog Diseases; D004285:Dogs; D005269:Femur / Q000000981:diagnostic imaging; D015675:Osteocalcin / Q000097:blood*; D010019:Osteomyelitis / Q000097:blood / Q000503:physiopathology / Q000662:veterinary*; D010455:Peptides / Q000097:blood*; D011859:Radiography
D015415:Biomarkers; D024042:Collagen Type I; D010455:Peptides; C052929:collagen type I trimeric cross-linked peptide; D015675:Osteocalcin; D003094:Collagen; D000469:Alkaline Phosphatase