title: Determination events in the nervous system of the vertebrate embryo.
abstract: Molecular and functional data suggest that the regionalization of the caudal portion of the vertebrate embryonic brain (hindbrain) is set up through a process of segmentation. In contrast, the more rostrally located met-mesencephalic domain (mid-hindbrain junction) appears to follow a mode of specification that relies on long-range inducing and organizing activities originating from the central region of the domain. Recent studies addressing this mode of anterior/posterior determination point to Wnt-1 as a key player in this process.
authors.affiliation: Department of Molecular Biology, Princeton University, New Jersey 08544, USA.
authors.forename: L
authors.initials: L
authors.lastname: Bally-Cuif
authors.forename: M
authors.initials: M
authors.lastname: Wassef
mesh_terms: D000818:Animals; D002490:Central Nervous System / Q000196:embryology*; D002531:Cerebellum / Q000196:embryology; D004627:Embryonic Induction; D008636:Mesencephalon / Q000196:embryology*; D011518:Proto-Oncogene Proteins / Q000502:physiology; D014714:Vertebrates / Q000196:embryology*; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins
chemical_list: D011518:Proto-Oncogene Proteins; D051153:Wnt Proteins; D051155:Wnt1 Protein; D029961:Zebrafish Proteins