Individual psychotherapies for depressed HIV-positive patients.
OBJECTIVE
The authors present preliminary data from two treatment modalities of a randomized clinical trial in which they compared 16-week interventions of interpersonal psychotherapy to supportive psychotherapy.


METHODS
HIV-positive patients who were not acutely medically ill and had scores of 15 or higher on the Hamilton Depression Rating Scale were randomly assigned to one of four treatment modalities. They were assessed by the Hamilton scale and Beck Depression Inventory at 8 and 16 weeks. Most subjects who underwent either interpersonal psychotherapy (N = 16) or supportive psychotherapy (N = 16) were male, gay or bisexual, white, and college educated.


RESULTS
Results of last-observation-carried-forward and completer analyses showed that scores on the Hamilton scale and Beck Depression Inventory decreased significantly for both treatments. Differential improvement for interpersonal psychotherapy appeared by midtreatment (week 8) and persisted at termination.


CONCLUSIONS
This is the first controlled study of individual psychotherapies for depressed HIV-positive patients. Results suggest that a specific antidepressant psychotherapy, interpersonal psychotherapy, has advantages over a supportive therapy.
Markowitz
J C
JC
Department of Psychiatry, Cornell University Medical College, New York, NY 10021, USA.
Klerman
G L
GL
Clougherty
K F
KF
Spielman
L A
LA
Jacobsberg
L B
LB
Fishman
B
B
Frances
A J
AJ
Kocsis
J H
JH
Perry
S W
SW
D003866:Depressive Disorder / Q000175:diagnosis / Q000523:psychology / Q000628:therapy*; D004522:Educational Status; D005500:Follow-Up Studies; D006679:HIV Seropositivity / Q000150:complications*; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011613:Psychotherapy / Q000379:methods*; D012737:Sex Factors; D016896:Treatment Outcome