Strange-male-induced pregnancy disruption in mice: potentiation by administration of 17 beta-estradiol to castrated males.
Previous evidence suggests that androgen activity is necessary for strange males to disrupt early pregnancy in mice. Inseminated females were housed below castrated males, separated by a wire-mesh grid. Castrated males did not disrupt pregnancy, whereas those given daily injections of 27 or 81 micrograms of 17 beta-estradiol did so. In conjunction with previous evidence, these data suggest a similarity between the hormones involved in the capacity of males to disrupt pregnancy and the hormones directly implicated in the females' vulnerability to pregnancy disruption.
De Catanzaro
D
D
Department of Psychology, McMaster University, Hamilton, Ontario, Canada.
Smith
M
M
Muir
C
C
D000818:Animals; D004958:Estradiol / Q000494:pharmacology*; D005260:Female; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009919:Orchiectomy; D011247:Pregnancy; D011256:Pregnancy Outcome / Q000523:psychology*; D011270:Pregnancy, Animal / Q000502:physiology*
D004958:Estradiol