Anticardiolipin antibodies in acute non-hemorrhagic stroke seen within six hours after onset.
BACKGROUND
We have undertaken a prospective study to measure anticardiolipin antibodies of IgG isotype within the first few hours of an acute non-hemorrhagic stroke.


METHODS
We have collected blood samples at entry from one hundred patients (53 men and 47 women), mean age 67.4 years, referred within 6 h of a first-ever non-hemorrhagic stroke, and from an equal number of age- and gender-matched control patients.


RESULTS
IgG anticardiolipin antibodies were > or = 10 GPL in 26 patients and in 5 controls (p < 0.0001, X2 test). After logistic regression analysis, increase of IgG anticardiolipin antibodies remained independently associated with stroke (p = 0.0034), together with hypertension (p = 0.0009) and atrial fibrillation (p = 0.0238).


CONCLUSIONS
Our data suggest that the occurrence of elevation of IgG anticardiolipin antibodies in stroke patients should antedate stroke onset and might be a risk factor per se.
Camerlingo
M
M
2nd Neurological Department, Ospedali Riuniti, Bergamo, Italy.
Casto
L
L
Censori
B
B
Drago
G
G
Frigeni
A
A
Ferraro
B
B
Servalli
M C
MC
Radice
E
E
Mamoli
A
A
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017153:Antibodies, Anticardiolipin / Q000097:blood*; D016736:Antiphospholipid Syndrome / Q000175:diagnosis / Q000276:immunology*; D002561:Cerebrovascular Disorders / Q000175:diagnosis / Q000276:immunology*; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D008875:Middle Aged; D012307:Risk Factors
D017153:Antibodies, Anticardiolipin; D007074:Immunoglobulin G