title: Phenotypic and functional parameters of cellular immunity in a chimpanzee with a naturally acquired simian immunodeficiency virus infection.
abstract: The cellular immunologic and virologic status of a chimpanzee, naturally infected with a human immunodeficiency virus type 1 (HIV-1)-like lentivirus (SIVcpz-ant), was compared longitudinally with those of 3 HIV-1-infected and 5 uninfected chimpanzees for a period of 49 months. Evidence of immune deficiency was not observed in the HIV-1-infected chimpanzees, nor could virus be isolated from plasma. Virus could be isolated from plasma of the SIVcpz-ant-infected chimpanzee, but clinical signs of immune deficiency were never observed. Absolute CD4+ cell counts remained relatively stable, but NK cells fluctuated significantly over time and tended to correlate inversely with the virus titer in peripheral blood. Although only CD8+ T cells were directly demonstrated to exert a suppressive effect on viral replication in vitro, the observed fluctuation of NK cells suggests that these cells may also be involved in the interaction with lentivirus infection in this species.
authors.affiliation: Laboratory of Pathology-Immunology, Institute of Tropical Medicine, Antwerp, Belgium.
authors.forename: L
authors.initials: L
authors.lastname: Kestens
authors.forename: J
authors.initials: J
authors.lastname: Vingerhoets
authors.forename: M
authors.initials: M
authors.lastname: Peeters
authors.forename: G
authors.initials: G
authors.lastname: Vanham
authors.forename: C
authors.initials: C
authors.lastname: Vereecken
authors.forename: G
authors.initials: G
authors.lastname: Penne
authors.forename: H
authors.initials: H
authors.lastname: Niphuis
authors.forename: P
authors.initials: P
authors.lastname: van Eerd
authors.forename: G
authors.initials: G
authors.lastname: van der Groen
authors.forename: P
authors.initials: P
authors.lastname: Gigase
mesh_terms: D000818:Animals; D000830:Animals, Laboratory; D017252:CD3 Complex; D015496:CD4-Positive T-Lymphocytes; D018414:CD8-Positive T-Lymphocytes; D003602:Cytotoxicity, Immunologic; D005500:Follow-Up Studies; D015497:HIV-1 / Q000145:classification; D007111:Immunity, Cellular; D007694:Killer Cells, Natural; D007963:Leukocytes, Mononuclear / Q000821:virology; D008213:Lymphocyte Activation; D016131:Lymphocyte Subsets; D008297:Male; D002679:Pan troglodytes; D016097:Simian Acquired Immunodeficiency Syndrome / Q000097:blood / Q000276:immunology* / Q000662:veterinary*; D015302:Simian Immunodeficiency Virus / Q000145:classification / Q000254:growth & development / Q000276:immunology
chemical_list: D017252:CD3 Complex