The use of adenoviral vectors for gene therapy and gene transfer in vivo.
Adenoviral vectors have proven to be excellent vehicles for gene delivery in vivo to a wide range of cell types. These vectors have been used to transfer genes such as CFTR to correct the defect in cystic fibrosis and, more recently, to supply serum blood factors and genetically modify tumors to enhance therapy.
Bramson
J L
JL
McMaster University, Hamilton, Canada.
Graham
F L
FL
Gauldie
J
J
D000256:Adenoviridae / Q000235:genetics*; D018014:Gene Transfer Techniques; D015316:Genetic Therapy / Q000379:methods*; D005822:Genetic Vectors; D006801:Humans