[Poststress lesions of the gastric mucosa in inbred mice after the peripheral administration of cyproheptadine and propranolol].
Intraperitoneal administration of 5-HT2-receptor blocking agent ciproheptadine abolished the protective effect on stress-induced damage of gastric mucosa in male mice, while propranolol depresses this protective effect. Propranolol prevented a damaging effect of serotonine on gastric mucosa. Consequences of emotional stress on gastric mucosa seem to be realised through different types of serotoninergic receptors.
Koriakina
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LA
D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D003404:Creatinine / Q000008:administration & dosage / Q000494:pharmacology; D003533:Cyproheptadine / Q000008:administration & dosage / Q000494:pharmacology*; D004338:Drug Combinations; D005753:Gastric Mucosa / Q000187:drug effects* / Q000473:pathology; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D011433:Propranolol / Q000008:administration & dosage / Q000494:pharmacology*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D012149:Restraint, Physical; D012701:Serotonin / Q000008:administration & dosage / Q000494:pharmacology; D012702:Serotonin Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D013315:Stress, Psychological / Q000503:physiopathology*
D000319:Adrenergic beta-Antagonists; D004338:Drug Combinations; D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; C014050:creatinine sulfate, serotonin drug combination; D003533:Cyproheptadine; D012701:Serotonin; D011433:Propranolol; D003404:Creatinine
Poststressornye porazheniia slizistoĭ obolochki zheludka inbrednykh mysheĭ posle perifericheskogo vvedeniia tsiprogeptadina i propranolola.