Alterations in GABAA receptor binding in the prefrontal cortex following exposure to chronic stress.
The present study was designed to examine the effects of chronic stress on GABAA receptor binding. Animals were randomly assigned to either a control, acute, or chronic stress condition and changes in specific binding were assessed using the GABAA receptor antagonist [3H]SR 95531. Exposure to chronic restraint stress led to a significant reduction in GABAA receptor binding in the prefrontal cortex. Alterations in specific binding were not observed in the cerebellum, caudate-putamen, hippocampus, or cingulate cortex however, suggesting that the effects of chronic stress may be regionally specific. Exposure to acute restraint did not lead to a significant alteration in [3H]SR 95531 binding in any brain region examined.
Gruen
R J
RJ
Department of Psychiatry, New York University, New York 10003, USA.
Wenberg
K
K
Elahi
R
R
Friedhoff
A J
AJ
D000818:Animals; D002908:Chronic Disease; D058787:GABA-A Receptor Antagonists; D008297:Male; D017397:Prefrontal Cortex / Q000378:metabolism*; D011724:Pyridazines / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D011963:Receptors, GABA-A / Q000378:metabolism*; D012149:Restraint, Physical; D013312:Stress, Physiological / Q000378:metabolism*
D058787:GABA-A Receptor Antagonists; D011724:Pyridazines; D011963:Receptors, GABA-A; C049853:gabazine