Three more cyclotheonamides, C, D, and E, potent thrombin inhibitors from the marine sponge Theonella swinhoei.
Three new thrombin and trypsin inhibitors, cyclotheonamides C (3), D (4), and E (8) were isolated from the marine sponge Theonella swinhoei. Their structures were determined by spectral and chemical methods.
Nakao
Y
Y
Laboratory of Marine Biochemistry, Faculty of Agriculture, University of Tokyo, Japan.
Matsunaga
S
S
Fusetani
N
N
D000818:Animals; D000991:Antithrombins / Q000737:chemistry* / Q000302:isolation & purification*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification; D011161:Porifera; D015842:Serine Proteinase Inhibitors / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors*; D014361:Trypsin Inhibitors / Q000737:chemistry / Q000302:isolation & purification*
D000991:Antithrombins; D010456:Peptides, Cyclic; D015842:Serine Proteinase Inhibitors; D014361:Trypsin Inhibitors; C096691:cyclotheonamide C; C096692:cyclotheonamide D; C096693:cyclotheonamide E; D013917:Thrombin