Characteristics of DQ2511-induced relaxation in isolated dog, monkey and human arteries.
DQ2511, a possible antiulcer agent, relaxed dog, monkey and human arterial strips from various organs; the effect was most evident in the gastroepiploic artery. The relaxation was not influenced by timolol, atropine, dopamine receptor antagonists, and K+-channel blockers, but partially attenuated by oxyhemoglobin endothelium denudation. Treatment with DQ2511 increased the relaxant response to sodium nitroprusside and a prostaglandin I2 analog in dog gastroepiploic arteries and potentiated the stimulating effect of these agonists on the contents of cyclic GMP and cyclic AMP, respectively. It is concluded that DQ2511 relaxes gastroepiploic arteries predominantly over the other arteries; the relaxation appears to be derived partially from phosphodiesterase inhibition.
Okamura
T
T
Department of Pharmacology, Shiga University of Medical Science, Ohtsu, Japan.
Ide
S
S
Toda
N
N
D000818:Animals; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D001158:Arteries / Q000187:drug effects*; D001549:Benzamides / Q000494:pharmacology*; D004285:Dogs; D004298:Dopamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008251:Macaca; D008297:Male; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D014664:Vasodilation / Q000187:drug effects*
D000897:Anti-Ulcer Agents; D001549:Benzamides; C058308:ecabapide; D010727:Phosphoric Diester Hydrolases; D004298:Dopamine