title: Evidence for an antiviral effect and interferon neutralizing capacity in human sera; variability and implications for HIV infection.
abstract: The antiviral effect (AVE) and interferon neutralizing capacity (INC) of sera originating from either seronegative or HIV-infected individuals were determined. As a rule, sera from seropositive subjects exhibited higher AVE titers than sera from seronegative individuals. Similarly, the INC of sera from HIV-infected patients, was most often stronger than that of sera from seronegative individuals. Furthermore, sera from HIV-infected patients actively immunized with i-IFN alpha invariably expressed INC in response to treatment, which was not the case for sera from control unimmunized patients. All sera from HIV-infected patients were found by ELISA to contain antibodies specifically directed to IFN alpha.
authors.affiliation: Laboratoire de Physiologie Cellulaire, Université Pierre et Marie Curie, Paris, France.
authors.forename: L S
authors.initials: LS
authors.lastname: Fall
authors.forename: V
authors.initials: V
authors.lastname: Chams
authors.forename: H
authors.initials: H
authors.lastname: Le Coq
authors.forename: M
authors.initials: M
authors.lastname: Fouchard
authors.forename: J P
authors.initials: JP
authors.lastname: M'Bika
authors.forename: A
authors.initials: A
authors.lastname: Gringeri
authors.forename: E
authors.initials: E
authors.lastname: Santagostino
authors.forename: B
authors.initials: B
authors.lastname: Bizzini
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology* / Q000821:virology; D000914:Antibodies, Viral / Q000276:immunology*; D000917:Antibody Formation; D000998:Antiviral Agents / Q000097:blood; D018791:CD4 Lymphocyte Count; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D007106:Immune Sera / Q000276:immunology*; D016898:Interferon-alpha / Q000097:blood / Q000276:immunology*; D008297:Male; D009500:Neutralization Tests; D013997:Time Factors; D014611:Vaccination; D014614:Vaccines, Synthetic / Q000276:immunology
chemical_list: D000914:Antibodies, Viral; D000998:Antiviral Agents; D007106:Immune Sera; D016898:Interferon-alpha; D014614:Vaccines, Synthetic