Stimulation of median, but not dorsal, raphe 5-HT1A autoreceptors by the local application of 8-OH-DPAT reverses raclopride-induced catalepsy in the rat.
The local application of 8-OH-DPAT (0.5 or 2.5 micrograms/rat, 10 min) into the median, but not the dorsal, raphe nucleus resulted in a reversal of the catalepsy induced by the DA D2 receptor blocking agent raclopride (16 mg kg-1 s.c., 60 min). The local application of 8-OH-DPAT into serotonergic projection areas of the forebrain (dorso-lateral neostriatum, accumbens core; 0.5 or 2.0 micrograms/side) did not affect raclopride-induced catalepsy. Thus, the 5-HT1A autoreceptor in the median raphe nucleus is an important site of action for the reversal of DA D2 receptor antagonist-induced catalepsy by systemic administration of 5-HT1A receptor agonists, in the rat.
Wadenberg
M L
ML
Department of Psychology, University of Stockholm, Sweden.
Hillegaart
V
V
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000494:pharmacology*; D000818:Animals; D017660:Autoreceptors; D002375:Catalepsy / Q000139:chemically induced; D018492:Dopamine Antagonists / Q000494:pharmacology*; D007278:Injections, Spinal; D020891:Raclopride; D011903:Raphe Nuclei / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000187:drug effects*; D012457:Salicylamides / Q000494:pharmacology*; D013997:Time Factors
D017660:Autoreceptors; D018492:Dopamine Antagonists; D011985:Receptors, Serotonin; D012457:Salicylamides; D020891:Raclopride; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin