Functional platelet-derived growth factor-beta (PDGF-beta) receptor expressed on early B-lineage precursor cells.
Growth and maturation of B lymphocytes from stem cells require a series of complex processes that are dependent at least in part on growth factors. Uncontrolled expression of receptors from these early growth factors may contribute to a leukaemogenesis of such early B cell progenitors. We show here that early pre-pre-B cells, but not mature B cells, express the PDGF receptor-beta (PDGFR-beta). These receptors contain a protein tyrosine kinase domain which is activated upon ligation with PDGF in pre-pre-B cells. Further, pre-pre-B leukaemia cells seem to express more PDGFR-beta compared with their normal counterparts, suggesting a role for these receptors in growth promotion of leukaemia cells.
Trink
B
B
Division of Immunology/Allergy, Hospital for Sick Children, University of Toronto, Ontario, Canada.
Wang
G
G
Shahar
M
M
Meydan
N
N
Roifman
C M
CM
D001402:B-Lymphocytes / Q000166:cytology* / Q000378:metabolism; D001483:Base Sequence; D002118:Calcium / Q000378:metabolism; D002453:Cell Cycle / Q000187:drug effects; D017931:DNA Primers / Q000737:chemistry; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004789:Enzyme Activation; D015870:Gene Expression; D006410:Hematopoiesis; D006801:Humans; D008969:Molecular Sequence Data; D010716:Phosphatidylinositols / Q000378:metabolism; D019000:Phosphotyrosine / Q000378:metabolism; D010982:Platelet-Derived Growth Factor / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics; D020794:Receptor Protein-Tyrosine Kinases / Q000378:metabolism; D017479:Receptors, Platelet-Derived Growth Factor / Q000378:metabolism*; D015398:Signal Transduction; D014407:Tumor Cells, Cultured; D010738:Type C Phospholipases / Q000378:metabolism
D017931:DNA Primers; D004273:DNA, Neoplasm; D010716:Phosphatidylinositols; D010982:Platelet-Derived Growth Factor; D012333:RNA, Messenger; D019000:Phosphotyrosine; D020794:Receptor Protein-Tyrosine Kinases; D017479:Receptors, Platelet-Derived Growth Factor; D010738:Type C Phospholipases; D002118:Calcium