title: [Diffuse lung hemorrhage and necrotizing glomerulonephritis in a case of Wegener's granulomatosis. Diagnostic and therapeutic approach].
abstract: We present the case of a 59 years old male with Wegener's Granulomatosis with uncommon manifestations such as diffuse pulmonary hemorrhage and acute renal failure due to necrotizing glomerulonephritis. Neutrophil anticytoplasmic antibodies determination was negative. Conventional and high resolution thoracic computed tomography showed cavitated lung nodules with small peripheral vessels. These lesions, that are characteristic of this type of vasculitis, were not appreciated on the routine chest roetgenogram. Definitive diagnosis was made by the histological study of open lung and renal biopsies. Favourable response to corticosteroids, immunosuppressive drugs and hemodialysis was obtained. Diffuse pulmonary hemorrhage is an uncommon manifestation of Wegener's Granulomatosis, and must be considered as a vital emergency that justify the use of aggressive diagnostic and therapeutic methods.
authors.affiliation: Servicio de Neumología, Hospital Universitario del Aire, Madrid.
authors.forename: F R
authors.initials: FR
authors.lastname: Villegas Fernández
authors.forename: L
authors.initials: L
authors.lastname: Callol Sánchez
authors.forename: M J
authors.initials: MJ
authors.lastname: Chillon Martín
authors.forename: J
authors.initials: J
authors.lastname: Jareño Esteban
authors.forename: M
authors.initials: M
authors.lastname: Moreno Muro
authors.forename: A
authors.initials: A
authors.lastname: Cuevas Ibáñez
authors.forename: F J
authors.initials: FJ
authors.lastname: Gómez-Terreros
mesh_terms: D005921:Glomerulonephritis / Q000209:etiology* / Q000473:pathology; D014890:Granulomatosis with Polyangiitis / Q000150:complications / Q000175:diagnosis* / Q000628:therapy*; D006470:Hemorrhage / Q000209:etiology*; D006801:Humans; D008171:Lung Diseases / Q000209:etiology*; D008297:Male; D008875:Middle Aged; D009336:Necrosis
vernacular_title: Hemorragia pulmonar difusa y glomerulonefritis necrotizante en un caso de granulomatosis de Wegener. Actitud diagnóstica y terapéutica.