Severe intracranial hemorrhage in a newborn infant with transplacental transfer of an acquired factor VII:C inhibitor.
We describe a woman in whom inhibitors to factor VIII:C developed in her first pregnancy. The neonate had a factor VIII:C level of 1% and an inhibitor titer of 5.2 Bethesda units. After an uneventful vaginal delivery, the boy had an intracranial hemorrhage at 5 days of age. To our knowledge, this is the first report of a bleeding complication in a newborn infant with transplacental transfer of an acquired factor VIII:C inhibitor.
Ries
M
M
Klinik mit Poliklinik für Kinder und Jugendliche, Universität Erlangen, Nuremberg, Germany.
Wölfel
D
D
Maier-Brandt
B
B
D002543:Cerebral Hemorrhage / Q000150:complications / Q000175:diagnosis / Q000503:physiopathology*; D005169:Factor VIII; D005260:Female; D006467:Hemophilia A / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008431:Maternal-Fetal Exchange; D009778:Occipital Lobe / Q000503:physiopathology*; D011247:Pregnancy; D014057:Tomography, X-Ray Computed
D005169:Factor VIII