Neural transplantation.
Cell transplantation is now being explored as a new therapeutic strategy to restore function in the diseased human central nervous system. Neural grafts show long-term survival and function in patients with Parkinson's disease but the symptomatic relief needs to be increased. Cell transplantation seems justified in patients with Huntington's disease and, at a later stage, possibly also in demyelinating disorders. The further development in this research field will require systematic studies in animal experiments but also well-designed clinical trials in small groups of patients.
Lindvall
O
O
Department of Neurology, University Hospital, Lund, Sweden.
D000818:Animals; D016380:Brain Tissue Transplantation; D002478:Cells, Cultured / Q000637:transplantation; D004298:Dopamine / Q000378:metabolism; D016332:Fetal Tissue Transplantation; D005818:Genetic Engineering; D006085:Graft Survival; D006801:Humans; D009474:Neurons / Q000378:metabolism / Q000637:transplantation; D010300:Parkinson Disease / Q000601:surgery*; D010302:Parkinson Disease, Secondary / Q000601:surgery; D051381:Rats
D004298:Dopamine