title: Heavy metal effects on Proteus mirabilis superoxide dismutase production.
abstract: Proteus mirabilis expressed three superoxide dismutase activities, which depended on the level of soluble iron and dioxygen in the culture medium. Cadmium and lead decreased production of super oxide dismutase in liquid culture and on solid medium. A fourth super oxide dismutase activity appeared in extracts from cells grown in the presence of cadmium. These results support the idea of an interaction between toxic metal ions and putative iron- and redox-dependent regulatory systems.
authors.affiliation: School of Medicine, Southern Illinois University at Carbondale 62901-4413, USA.
authors.forename: J
authors.initials: J
authors.lastname: Eickhoff
authors.forename: E
authors.initials: E
authors.lastname: Potts
authors.forename: J
authors.initials: J
authors.lastname: Valtos
authors.forename: E C
authors.initials: EC
authors.lastname: Niederhoffer
mesh_terms: D002104:Cadmium / Q000494:pharmacology*; D015964:Gene Expression Regulation, Bacterial; D007527:Isoenzymes / Q000096:biosynthesis*; D007854:Lead / Q000494:pharmacology*; D010084:Oxidation-Reduction; D011513:Proteus mirabilis / Q000187:drug effects* / Q000201:enzymology; D015398:Signal Transduction; D013482:Superoxide Dismutase / Q000096:biosynthesis*
chemical_list: D007527:Isoenzymes; D002104:Cadmium; D007854:Lead; D013482:Superoxide Dismutase