Poisoning with anti-hypertensive drugs: alpha-adrenoceptor antagonists.
Experience with overdosage and toxicity with the alpha (alpha)-adrenoceptor antagonists remains very limited, and all the cases in the literature relate to prazosin overdosage. The selective alpha-blocker appears, however, to have a low acute toxicity. Supportive therapy by the reduction of gastrointestinal absorption, monitoring of vital signs and the correction of hypotension (with intravenous fluids) is indicated.
Lip
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West Midlands Centre for Adverse Drug Reaction Reporting, City Hospital, Birmingham, UK.
Ferner
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D000317:Adrenergic alpha-Antagonists / Q000506:poisoning*; D000959:Antihypertensive Agents / Q000506:poisoning*; D002319:Cardiovascular System / Q000187:drug effects; D062787:Drug Overdose / Q000628:therapy; D006801:Humans; D001523:Mental Disorders / Q000139:chemically induced; D009420:Nervous System / Q000187:drug effects
D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents