title: Requirement of the ETS domain transcription factor D-ELG for egg chamber patterning and development during Drosophila oogenesis.
abstract: The D-elg gene encodes an ETS domain transcription factor that functions in Drosophila oogenesis. D-elg belongs to a small group of genes that are required for the formation of both the anteroposterior and dorsoventral axes of the egg chamber. During oogenesis in D-elg mutant females, the spatial localization of oskar and gurken mRNAs in the oocyte is disrupted and a follicle cell enhancer trap marker identifies dorsoventral polarity defects. Also, specialized follicle cells, called border cells, fail to migrate from their anterior location to a position adjacent to the developing oocyte. Consistent with these phenotypes, D-elg shows genetic interactions with two genes required for normal egg chamber differentiation.
authors.affiliation: Department of Biochemistry and Molecular Biology, University of Texas MD Anderson Cancer Center, Houston 77030, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Gajewski
authors.forename: R A
authors.initials: RA
authors.lastname: Schulz
mesh_terms: D000818:Animals; D002465:Cell Movement; D004330:Drosophila / Q000502:physiology*; D029721:Drosophila Proteins; D005260:Female; D018398:Homeodomain Proteins; D007301:Insect Hormones / Q000235:genetics; D009154:Mutation; D009866:Oogenesis; D011518:Proto-Oncogene Proteins / Q000235:genetics / Q000502:physiology*; D012333:RNA, Messenger / Q000032:analysis; D015534:Trans-Activators
chemical_list: D029721:Drosophila Proteins; D018398:Homeodomain Proteins; D007301:Insect Hormones; D011518:Proto-Oncogene Proteins; D012333:RNA, Messenger; D015534:Trans-Activators; C056478:bcd protein, Drosophila; C070138:Ets97D protein, Drosophila