Identification and cloning of the G3B cDNA encoding a 3' segment of a protein binding to GATA-3.
The transcription factor GATA-3 contributes to the expression of several genes critical for T-cell function and development, including the T-cell receptor alpha and beta chains. We report here the isolation of a human cDNA clone which encodes a 3' segment of a novel protein with three zinc fingers. This protein, which we termed G3B, can interact with GATA-3 in vitro. Its mRNA is expressed in T and B cells. Thus, G3B may represent a potential regulator of GATA-3 function.
Shapiro
V S
VS
Department of Molecular and Cell Biology, University of California at Berkeley 94720-3200, USA.
Lee
P
P
Winoto
A
A
D000595:Amino Acid Sequence; D001402:B-Lymphocytes / Q000378:metabolism; D001483:Base Sequence; D002460:Cell Line; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics / Q000302:isolation & purification; D004268:DNA-Binding Proteins / Q000378:metabolism*; D050990:GATA3 Transcription Factor; D006801:Humans; D008969:Molecular Sequence Data; D011485:Protein Binding; D012333:RNA, Messenger / Q000096:biosynthesis; D013601:T-Lymphocytes / Q000378:metabolism; D015534:Trans-Activators / Q000378:metabolism*; D016335:Zinc Fingers
D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D050990:GATA3 Transcription Factor; C494749:GATA3 protein, human; D012333:RNA, Messenger; D015534:Trans-Activators