title: Taurine prevents haloperidol-induced changes in striatal neurochemistry and behavior.
abstract: Repeated daily administration of haloperidol produces changes in striatal neurochemistry (decreased dopamine synthesis, upregulation of D2 receptors) and behavior (increasing catalepsy). Coadministration of taurine greatly attenuated these neuroleptic-induced changes. Possible mechanisms of taurine's mitigating effects are its attenuating influences on glutamatergic transmission and its actions as a GABAA agonist. The possibility was discussed of adding taurine to chronic antipsychotic regimens to block the side-effects typically accompanying such therapy.
authors.affiliation: Department of Psychobiology, NYS Institute for Basic Research, Staten Island 10314, USA.
authors.forename: T I
authors.initials: TI
authors.lastname: Lidsky
authors.forename: J S
authors.initials: JS
authors.lastname: Schneider
authors.forename: E
authors.initials: E
authors.lastname: Yablonsky-Alter
authors.forename: L G
authors.initials: LG
authors.lastname: Zuck
authors.forename: S P
authors.initials: SP
authors.lastname: Banerjee
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000037:antagonists & inhibitors*; D002375:Catalepsy / Q000139:chemically induced*; D003342:Corpus Striatum / Q000187:drug effects* / Q000378:metabolism; D004334:Drug Administration Schedule; D005069:Evaluation Studies as Topic; D018698:Glutamic Acid / Q000378:metabolism; D006220:Haloperidol / Q000037:antagonists & inhibitors*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013654:Taurine / Q000494:pharmacology*
chemical_list: D014150:Antipsychotic Agents; D013654:Taurine; D018698:Glutamic Acid; D006220:Haloperidol