Inositol phosphates in the heart: controversy and consensus.
Numerous studies have addressed various aspects of inositol phosphate release and metabolism in myocardial preparations, and many different viewpoints have been expressed. The various results and interpretations presented often appear confusing and extracting a consensus view can be difficult. The differences often derive from the differing cardiac preparations used, especially isolated cells versus intact tissue. Despite these problems there are aspects where consensus prevails. Both the metabolism and the functional activity of inositol phosphates in heart appear to differ from those previously described in non-excitable cells. Inositol phosphates do not appear to be of major importance in the control of cardiac function under physiological conditions but may well have greater influence under pathological conditions such as myocardial ischaemia and reperfusion. Hopefully, the near future will see remaining controversies resolved.
Woodcock
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EA
Cellular Biochemistry Laboratory, Baker Medical Research Institute, Prahran, Melbourne, Australia.
D000818:Animals; D002118:Calcium / Q000378:metabolism; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D007295:Inositol Phosphates / Q000378:metabolism*; D017202:Myocardial Ischemia / Q000378:metabolism; D015425:Myocardial Reperfusion; D009206:Myocardium / Q000378:metabolism*
D007295:Inositol Phosphates; D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium