The effectiveness of combined oral lysine acetylsalicylate and metoclopramide compared with oral sumatriptan for migraine.
Aspirin is commonly used to treat migraine attacks, although sumatriptan, a much more expensive treatment, is also effective. We compared a combination of lysine acetylsalicylate (equivalent to 900 mg aspirin) and 10 mg metoclopramide (LAS+MTC) with oral sumatriptan (100 mg) and placebo in 421 patients with migraine. LAS+MTC was as effective as sumatriptan with a decrease of headache from severe or moderate to mild or none of 57% and 53%, respectively, for the first migraine attack treated. Both treatments were better than placebo (success rate 24%, p < 0.0001). LAS+MTC was significantly more effective in the treatment of nausea than sumatriptan (p < 0.0001) and was better tolerated (adverse events in 18% and 28%, respectively, p < 0.05). LAS+MTC is as effective as sumatriptan in the treatment of migraine attacks. It is also much cheaper.
Tfelt-Hansen
P
P
Bispebjerg Hospital, Copenhagen, Denmark.
Henry
P
P
Mulder
L J
LJ
Scheldewaert
R G
RG
Schoenen
J
J
Chazot
G
G
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D000700:Analgesics / Q000191:economics / Q000627:therapeutic use*; D001241:Aspirin / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use; D018492:Dopamine Antagonists / Q000191:economics / Q000627:therapeutic use*; D004311:Double-Blind Method; D016527:Drug Costs; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008239:Lysine / Q000031:analogs & derivatives* / Q000191:economics / Q000627:therapeutic use; D008297:Male; D008787:Metoclopramide / Q000191:economics / Q000627:therapeutic use*; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D017366:Serotonin Receptor Agonists / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*; D018170:Sumatriptan / Q000009:adverse effects / Q000191:economics / Q000627:therapeutic use*
D000700:Analgesics; D018492:Dopamine Antagonists; D017366:Serotonin Receptor Agonists; D018170:Sumatriptan; D008239:Lysine; D008787:Metoclopramide; D001241:Aspirin; C010395:acetylsalicylic acid lysinate