title: Genetic mapping and expression analysis of the murine DNA ligase I gene.
abstract: We mapped the murine DNA ligase I gene (Lig1) in the mouse genome by using a mapping panel from an interspecific cross. Lig1 mapped to a centromeric part of chromosome 7, a region homologous to human chromosome 19q, where the human homologue LIG1 was localized. In addition, Lig1 expression was analyzed during the course of mouse liver-cell regeneration induced by partial hepatectomy, necrogenic doses of carbon tetrachloride, or the mitogen 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene. The results demonstrate that Lig1 is expressed in the liver during active cell proliferation.
authors.affiliation: Division of Experimental Oncology A, Istituto Nazionale Tumori, Milan, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Gariboldi
authors.forename: A
authors.initials: A
authors.lastname: Montecucco
authors.forename: A
authors.initials: A
authors.lastname: Columbano
authors.forename: G M
authors.initials: GM
authors.lastname: Ledda-Columbano
authors.forename: E
authors.initials: E
authors.lastname: Savini
authors.forename: G
authors.initials: G
authors.lastname: Manenti
authors.forename: M A
authors.initials: MA
authors.lastname: Pierotti
authors.forename: T A
authors.initials: TA
authors.lastname: Dragani
mesh_terms: D000818:Animals; D002252:Carbon Tetrachloride Poisoning / Q000201:enzymology; D002455:Cell Division; D002874:Chromosome Mapping; D011088:DNA Ligases / Q000235:genetics*; D005260:Female; D015870:Gene Expression; D008040:Genetic Linkage; D006498:Hepatectomy; D008115:Liver Regeneration; D008297:Male; D051379:Mice / Q000235:genetics*; D008815:Mice, Inbred Strains; D012150:Polymorphism, Restriction Fragment Length; D011725:Pyridines / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics
chemical_list: D011725:Pyridines; D012333:RNA, Messenger; C028474:1,4-bis(2-(3,5-dichloropyridyloxy))benzene; D011088:DNA Ligases