title: Intracranial haemorrhage in a dobermann puppy with von Willebrand's disease.
abstract: Neurological examination of a lethargic, ataxic 12-week-old dobermann revealed decreased conscious proprioception in all its limbs. Haematological examination revealed a low platelet count. Cytological examination of a sample of cerebrospinal fluid revealed evidence of haemorrhage and chronic inflammation. The levels of von Willebrand's factor antigen were extremely low. Skull radiographs were consistent with mild hydrocephalus. Treatment resulted in little clinical improvement and the animal was euthanased. Post mortem examination of the brain revealed an internal hydrocephalus with haemorrhage into the ventricles. It was considered that the animal had suffered severe intracranial haemorrhage as a result of its low level of von Willebrand's factor antigen and that the bleeding may have been potentiated by the low platelet count.
authors.affiliation: Department of Clinical Veterinary Medicine, University of Cambridge.
authors.forename: K J
authors.initials: KJ
authors.lastname: Dunn
authors.forename: P K
authors.initials: PK
authors.lastname: Nicholls
authors.forename: J K
authors.initials: JK
authors.lastname: Dunn
authors.forename: M E
authors.initials: ME
authors.lastname: Herrtage
mesh_terms: D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology; D002543:Cerebral Hemorrhage / Q000209:etiology / Q000473:pathology / Q000662:veterinary*; D004283:Dog Diseases / Q000209:etiology* / Q000473:pathology; D004285:Dogs; D006849:Hydrocephalus / Q000000981:diagnostic imaging / Q000209:etiology / Q000662:veterinary; D008297:Male; D009069:Movement Disorders / Q000209:etiology / Q000662:veterinary; D010976:Platelet Count / Q000662:veterinary; D011859:Radiography; D013921:Thrombocytopenia / Q000150:complications / Q000473:pathology / Q000662:veterinary; D014842:von Willebrand Diseases / Q000150:complications / Q000662:veterinary*; D014841:von Willebrand Factor / Q000032:analysis
chemical_list: D014841:von Willebrand Factor