Assignment of the mouse homologue of a human MEN1 candidate gene, phospholipase C-beta 3 (Plcb3), to chromosome region 19B by FISH.
A recent study using comparative mapping analysis suggests that the proximal segment of mouse chromosome 19 contains the mouse homologs of the human multiple endocrine neoplasia type 1 (MEN1) flanking markers proximal to the locus. We have recently shown that phospholipase C-beta 3 (PLCB3) is a candidate gene for the MEN1 syndrome. In the present investigation we used fluorescence in situ hybridization with a genomic DNA clone for mouse Plcb3, and mapped the locus to chromosome region 19B. This is in agreement with the comparative mapping of the MEN1 flanking markers in mouse.
Gobl
A E
AE
Department of Internal Medicine, University Hospital, Uppsala, Sweden.
Chowdhary
B P
BP
Shu
W
W
Eriksson
L
L
Larsson
C
C
Weber
G
G
Oberg
K
K
Skogseid
B
B
D000818:Animals; D002874:Chromosome Mapping; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007527:Isoenzymes / Q000235:genetics*; D051379:Mice; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics*; D054799:Phospholipase C beta; D010738:Type C Phospholipases / Q000235:genetics*
D007527:Isoenzymes; D010738:Type C Phospholipases; C518039:PLCB3 protein, human; D054799:Phospholipase C beta; C518040:Plcb3 protein, mouse