title: The effect of change in sympatho-vagal balance on heart rate and blood pressure variability in the foetal lamb.
abstract: Cardiac and vascular function is mainly under autonomic nervous control within seconds to minutes, although the control is not mature at birth. We studied sympathovagal control of heart rate and blood pressure in chronically catheterized foetal lambs in the last trimester of gestation. Power spectral analysis was used to quantitate the frequency-specific heart rate variability (HRV) and blood pressure variability. We performed 15 experiments in seven foetal lambs. These preliminary studies showed that parasympathetic blockade by atropine (eight experiments) had no significant effect on the distribution of HRV to different frequencies. Beta-sympathetic blockade by propranolol (seven experiments) decreased the ratio of low and mid to high frequency (0.025-0.13 to 0.13-1.00 Hz) HRV (P = 0.02). The increased high frequency HRV in the absence of a similar increase in blood pressure variability and tracheal pressure variability suggests enhanced baroreflex responsiveness after propranolol administration. The frequency-specific sympathetic control of HRV in foetal lambs, the change in ratio of low and mid to high frequency HRV, might have clinical implications in estimating the level of foetal sympathetic activation in the follow-up of high-risk pregnancies.
authors.affiliation: Cardiorespiratory Research Unit, University of Turku, Finland.
authors.forename: T
authors.initials: T
authors.lastname: Metsälä
authors.forename: A
authors.initials: A
authors.lastname: Siimes
authors.forename: I
authors.initials: I
authors.lastname: Välimäki
mesh_terms: D000818:Animals; D001285:Atropine / Q000494:pharmacology; D001341:Autonomic Nervous System / Q000196:embryology / Q000502:physiology*; D001794:Blood Pressure / Q000502:physiology*; D005333:Fetus / Q000502:physiology; D006321:Heart / Q000196:embryology* / Q000502:physiology; D006339:Heart Rate / Q000502:physiology*; D011433:Propranolol / Q000494:pharmacology; D012119:Respiration / Q000502:physiology; D012756:Sheep
chemical_list: D001285:Atropine; D011433:Propranolol