Anti-neutrophil cytoplasmic antibodies in Japanese children with ulcerative colitis.
OBJECTIVE
To investigate the diagnostic value of anti-neutrophil cytoplasmic antibodies (ANCA) in the diagnosis of ulcerative colitis (UC) in Japanese children.


METHODS
Serum samples from 23 children with UC (17 Japanese, 6 non-Japanese), 27 children with Crohn's disease (CD) (10 Japanese, 17 non-Japanese), 10 children with other diarrhoeal diseases, and 33 normal, healthy adult volunteers were assayed for ANCA using an indirect immunofluorescence technique.


RESULTS
ANCA were detected in 6/17 (35%) UC patients and 0/10 (0%) CD patients in Japanese children, and in 3/6 (50%) UC patients and 3/17 (18%) CD patients in non-Japanese children. The difference in prevalence between Japanese and non-Japanese children with UC was not statistically significant (P > 0.05). ANCA were not found in other diarrhoeal patients and volunteers.


CONCLUSIONS
Although ANCA have been reported to be useful in the diagnosis of UC in adults, they may be of limited use in Japanese children. This might reflect the heterogeneity of UC.
Kaneko
K
K
Department of Pediatrics, Juntendo University School of Medicine, Tokyo, Japan.
Suzuki
Y
Y
Shimizu
T
T
Yamashiro
Y
Y
Yabuta
K
K
Lifschitz
C H
CH
D000293:Adolescent; D000328:Adult; D017668:Age of Onset; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D002648:Child; D002675:Child, Preschool; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000276:immunology*; D003424:Crohn Disease / Q000276:immunology; D003937:Diagnosis, Differential; D003967:Diarrhea / Q000276:immunology; D004797:Enzyme-Linked Immunosorbent Assay; D019084:Fluorescent Antibody Technique, Indirect; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008875:Middle Aged; D015995:Prevalence
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015415:Biomarkers