title: In vitro activity of tetracyclines, macrolides, quinolones, clindamycin and metronidazole against periodontopathic bacteria.
abstract: We re-evaluated several antibiotics including newer ones, for their in vitro killing activity, as well as their inhibitory activity, against clinical isolates of periodontopathic bacteria. Tetracyclines were active against Porphyromonas gingivalis, and were highly active against Prevotella intermedia, but demonstrated only a low killing activity against Actinobacillus actinomycetemcomitans. Rokitamycin, a new macrolide, and clindamycin were highly active against P. gingivalis and P. intermedia, but showed very weak killing activity against A. actinomycetemcomitans. Quinolones demonstrated excellent bactericidal activity against A. actinomycetemcomitans, and good inhibitory and bactericidal activity against P. gingivalis and P. intermedia. Metronidazole had an activity almost equivalent to quinolones against P. gingivalis and P. intermedia; but it was the least active against A. actinomycetemcomitans.
authors.affiliation: Department of Microbiology, Hiroshima University School of Dentistry, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Miyake
authors.forename: K
authors.initials: K
authors.lastname: Tsuruda
authors.forename: K
authors.initials: K
authors.lastname: Okuda
authors.lastname: Widowati
authors.forename: Y
authors.initials: Y
authors.lastname: Iwamoto
authors.forename: H
authors.initials: H
authors.lastname: Suginaka
mesh_terms: D016976:Aggregatibacter actinomycetemcomitans / Q000187:drug effects*; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000890:Anti-Infective Agents / Q000494:pharmacology; D000994:Antitrichomonal Agents; D002981:Clindamycin / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D024841:Fluoroquinolones; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology; D015644:Miocamycin / Q000031:analogs & derivatives / Q000494:pharmacology; D009287:Naphthyridines / Q000494:pharmacology; D015242:Ofloxacin / Q000494:pharmacology; D016966:Porphyromonas gingivalis / Q000187:drug effects*; D018713:Prevotella intermedia / Q000187:drug effects*; D015363:Quinolones / Q000494:pharmacology; D013752:Tetracycline / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D000890:Anti-Infective Agents; D000994:Antitrichomonal Agents; D024841:Fluoroquinolones; D009287:Naphthyridines; D015363:Quinolones; D008795:Metronidazole; D015644:Miocamycin; D002981:Clindamycin; D004917:Erythromycin; D015242:Ofloxacin; D013752:Tetracycline; D008911:Minocycline; C055185:tosufloxacin; C061363:sparfloxacin; C033383:rokitamycin