The influence of an PGF2x analogue and of some peptidoleukotrienes and platelet activating factor antagonists in experimentally induced gastric ulcer in rats.
We tested the influence of 30 mg/kg/per os BN 52021, 300 micrograms/kg Cloprostenol (CIPG) and of 5 mg/kg per os LY 171883B in stress restrain and indomethacin induced ulcers in rats. The data obtained show that CIPG and LY 171883 have a significant gastroprotective action in both ulcer models. BN 52021 has a significant protective activity in stress ulcer and less in indomethacin-induced ulcers.
Nechifor
M
M
Dept. Pharmacology, Univ. Med. Pharm., IASI, Romania.
Neughebauer
I B
IB
Costuleanu
M
M
Alomnicăi
M
M
Teslaru
E
E
Filip
C
C
Cocu
F
F
D000098:Acetophenones / Q000494:pharmacology*; D000818:Animals; D003008:Cloprostenol / Q000494:pharmacology*; D015237:Dinoprost / Q000031:analogs & derivatives; D004224:Diterpenes; D046934:Ginkgolides; D007213:Indomethacin; D007783:Lactones / Q000494:pharmacology*; D015289:Leukotrienes / Q000494:pharmacology; D008297:Male; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000139:chemically induced / Q000209:etiology / Q000517:prevention & control*; D013312:Stress, Physiological / Q000150:complications; D013777:Tetrazoles / Q000494:pharmacology*
D000098:Acetophenones; D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D015289:Leukotrienes; D010972:Platelet Activating Factor; D013777:Tetrazoles; D003008:Cloprostenol; C044660:LY 171883; D015237:Dinoprost; C045856:ginkgolide B; D007213:Indomethacin