Reversal of severe hepatic veno-occlusive disease by combined plasma exchange and rt-PA treatment.
We report the successful treatment of a case of severe hepatic veno-occlusive disease (VOD) by combined treatment with exchange plasmapheresis and fibrinolysis with rt-PA. Very advanced alterations of hepatic vascular circulation, evaluated by Doppler sonography, reverted to normal after treatment. Severe VOD, defined by McDonald's criteria, produces a mortality of 98%. This case suggests that this new method of combined treatment might contribute to changing the usually bad prognosis of this clinical condition.
Espigado
I
I
Servicio de Hematología y Hemoterapia, Hospital Universitario Virgen del Rocío, Sevilla, Spain.
Rodríguez
J M
JM
Parody
R
R
Carmona
M
M
Digón
J
J
Olloqui
E
E
D000328:Adult; D003131:Combined Modality Therapy; D005260:Female; D006504:Hepatic Veno-Occlusive Disease / Q000628:therapy*; D006801:Humans; D010951:Plasma Exchange; D011994:Recombinant Proteins / Q000627:therapeutic use; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D011994:Recombinant Proteins; D010959:Tissue Plasminogen Activator