A brief appraisal on some aspects of the receptor-receptor interaction.
Receptor-receptor interaction is being recognized as a key cellular mechanism responsible for the integration of signals between different transmission lines at the membrane level. Receptor-receptor interaction extends the classical concept of integration of depolarization and hyperpolarization effects to the integration of chemical events at membrane level. In the present paper only some hypotheses on the possible mechanistic aspects of the interactions between the membrane receptors will be discussed. Furthermore, possible functional consequences of receptor-receptor interaction will be explored. The limitations of the present experimental approaches to the study of receptor-receptor interaction will also be analysed.
Agnati
L F
LF
Institute of Human Physiology, University of Modena, Italy.
Ferré
S
S
Cortelli
P
P
Fuxe
K
K
D000818:Animals; D008564:Membrane Potentials / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*
D011956:Receptors, Cell Surface