Detection of brain-reactive autoantibodies in the sera of patients with systemic lupus erythematosus and cerebral involvement.
We modified, and applied to man, an ELISA established for the detection of brain-reactive autoantibodies in a murine model of SLE. We found brain-reactive antibody levels to be significantly higher in lupus patients than in healthy subjects. The antibody levels were significantly higher in lupus patients with central nervous system involvement than in those without.
Ochola
J
J
Department of Immunology, King's College School of Medicine and Dentistry, London, UK.
Hussain
M
M
Khamashta
M
M
Hughes
G R
GR
Vergani
D
D
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000276:immunology*; D001921:Brain / Q000276:immunology*; D001927:Brain Diseases / Q000150:complications / Q000276:immunology; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000276:immunology*; D008875:Middle Aged
D001323:Autoantibodies