Spiganthine, the cardioactive principle of Spigelia anthelmia.
Spiganthine [1] was isolated as the main cardioactive principle from medicinally used extracts of Spigelia anthelmia. Its structure was established by spectroscopic methods. The biological effect of spiganthine is characterized by a delay in contraction development of the heart muscle.
Achenbach
H
H
Institut für Pharmazie und Lebensmittelchemie der Universität Erlangen, Germany.
Hübner
H
H
Vierling
W
W
Brandt
W
W
Reiter
M
M
D000818:Animals; D002316:Cardiotonic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D004558:Electric Stimulation; D006168:Guinea Pigs; D006321:Heart / Q000187:drug effects*; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D009200:Myocardial Contraction / Q000187:drug effects; D010210:Papillary Muscles / Q000187:drug effects; D010946:Plants, Medicinal / Q000737:chemistry*; D012433:Ryanodine / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
D002316:Cardiotonic Agents; C095787:spiganthine; D012433:Ryanodine