Cerebral proton magnetic resonance spectroscopy in Rett syndrome.
Combined MRI/MRS studies were performed in 9 girls with Rett syndrome of different ages. NAA, as marker of neuronal tissue, was found to decrease with increasing age. There was no evidence for a defective energy metabolism. The data point towards a probably secondary degenerative process in the pathogenesis of Rett syndrome.
Hanefeld
F
F
Kinderklinik, Schwerpunkt Neuropädiatrie, Georg-August-Universität, Göttingen, Germany.
Christen
H J
HJ
Holzbach
U
U
Kruse
B
B
Frahm
J
J
Hänicke
W
W
D000293:Adolescent; D000328:Adult; D001921:Brain / Q000503:physiopathology*; D002648:Child; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D009410:Nerve Degeneration; D015518:Rett Syndrome / Q000175:diagnosis* / Q000503:physiopathology*; D012720:Severity of Illness Index