[Absorption of di-linoleoylphosphatidylcholine after oral administration].
Essentiale and Lipostabil contain "essential" phospholipids from the soybean, mainly 1,2-dilinoleoyl-phosphatidylcholine (CAS 998-06-1, DLPC) which is considered as the main active ingredient. A single oral dose of d15-DLPC loaded with deuterium 9 times in the choline and 6 times in the linoleic acid of the 1-position was given to volunteers. Sera from 11 blood samples taken within 48 h after application were examined by means of mass spectrometry with regard to d9-choline and d6-linoleic acid in the 1- and 2-position of serum phosphatidylcholines (PC) as well as in the serum triglycerides. d9-choline, i.e. the total of d15-PC and d9-PC, showed maximum values of 5.6% of the total serum PC concentration. Normally, about 1.3% of PC in the human serum is DLPC. Serum 1-linoleoyl-PC was increased by 32-40% after oral application of d15-DLPC. A minor uptake of d6-linoleic acid into the 2-position of serum PC, which is rich in linoleic acid, and into the serum triglycerides was observed with peak values of 2.3% and 6.1%, resp. The uptake of polyunsaturated PC species like DLPC and 1-linoleoyl-PC into the liver after oral application of drugs containing such species in high amounts like "essential" phospholipids with about 50% of DLPC let expect therapeutic effects on membranes into which this special species is incorporated.
Oette
K
K
Institut für Klinische Chemie der Universität zu Köln.
Kühn
G
G
Römer
A
A
Niemann
R
R
Gundermann
K J
KJ
Schumacher
R
R
D000215:Acylation; D000284:Administration, Oral; D000328:Adult; D006801:Humans; D007408:Intestinal Absorption; D008041:Linoleic Acids / Q000097:blood; D008297:Male; D013058:Mass Spectrometry; D010713:Phosphatidylcholines / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D014280:Triglycerides / Q000097:blood
D008041:Linoleic Acids; D010713:Phosphatidylcholines; D014280:Triglycerides; C002448:1,2-linoleoylphosphatidylcholine
Resorption von Dilinoleoyl-phosphatidylcholin nach oraler Gabe.