Developmental patterns of diurnal variations in 3-hydroxy-3-methylglutaryl coenzyme A reductase, D-site binding protein (DBP), and serine dehydratase mRNA levels in rat liver.
Rats were housed under a 12-hr light (07:00-19:00)/12-hr dark cycle. Hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase mRNA appeared at 3 weeks of age, and diurnal variation was established at 5 weeks of age. Diurnal variation of the D-Site binding protein (DBP) mRNA was faintly seen 1 week after birth and became evident with age. Serine dehydratase mRNA level was high at 11:00 in the livers of rats at 2-3 days of age, and at 15:00 in those at 1-2 weeks of age. The rhythm became ambiguous at 3-4 weeks of age, but an adult-type rhythm with a peak at 19:00 was established at 5 weeks of age.
Ogawa
H
H
Department of Biochemistry, Toyama Medical and Pharmaceutical University Faculty of Medicine, Japan.
Ansai
Y
Y
D000818:Animals; D015152:Blotting, Northern; D002940:Circadian Rhythm / Q000502:physiology; D004268:DNA-Binding Proteins; D005260:Female; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006903:Hydroxymethylglutaryl CoA Reductases / Q000235:genetics*; D012695:L-Serine Dehydratase / Q000235:genetics*; D008099:Liver / Q000201:enzymology / Q000254:growth & development / Q000378:metabolism*; D008297:Male; D010729:Phosphoenolpyruvate Carboxykinase (GTP) / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012727:Sex Characteristics; D014157:Transcription Factors / Q000235:genetics*
C485975:DBP protein, rat; D004268:DNA-Binding Proteins; D012333:RNA, Messenger; D014157:Transcription Factors; D006903:Hydroxymethylglutaryl CoA Reductases; D010729:Phosphoenolpyruvate Carboxykinase (GTP); D012695:L-Serine Dehydratase