Histochemical demonstration of interleukin-2 in decidua cells of patients with preeclampsia.
OBJECTIVE
The objective of this study was to gain insight into the immunological aspects of preeclampsia.


METHODS
The presence of interleukin-2 (IL-2) protein in the decidua was examined in five preeclamptic patients and seven normal pregnant women employing the immunohistochemistry.


RESULTS
The decidua cells were strongly stained for IL-2 in four out of five preeclamptic patients, while only very weak, if any, staining was observed in all the uncomplicated pregnant women.


CONCLUSIONS
IL-2 was clearly present in decidua cells in the preeclamptic setting, suggesting the possible involvement of immune-activation in the phathophysiology of preeclampsia.
Hara
N
N
Department of Obstetrics and Gynecology, School of Medicine, University of Tokyo, Japan.
Fujii
T
T
Okai
T
T
Taketani
Y
Y
D000328:Adult; D003656:Decidua / Q000737:chemistry / Q000276:immunology*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D007376:Interleukin-2 / Q000032:analysis*; D008431:Maternal-Fetal Exchange / Q000276:immunology; D011225:Pre-Eclampsia / Q000276:immunology* / Q000378:metabolism; D011247:Pregnancy
D007376:Interleukin-2