title: Pathway and regulation of JHIII-Bisepoxide biosynthesis in adult Drosophila melanogaster corpus allatum.
abstract: Adult female Drosophila melanogaster corpus allatum (CA) synthesize JHB3 from endogenous and exogenous precursors in vitro. We present evidence supporting the thesis that biosynthesis proceeds from precursor FA via initial epoxidation and terminal methylation on the basis of the following: (1) Methyl farnesoate is not epoxidized to JHIII or JHB3; (2) Authentic JHIII is not epoxidized to JHB3; and (3) FABE is markedly metabolized to JHB3. Cerebral allatostatic factors act at some stage subsequent to FA and this precursor is not normally rate-limiting. Additionally, neural inhibition from the brain acts at some biosynthetic step prior to FA.
authors.affiliation: Department of Entomology, Faculty of Agriculture, Hebrew University, Rehovot, Israel.
authors.forename: P
authors.initials: P
authors.lastname: Moshitzky
authors.forename: S W
authors.initials: SW
authors.lastname: Applebaum
mesh_terms: D000818:Animals; D003335:Corpora Allata / Q000378:metabolism*; D004331:Drosophila melanogaster / Q000378:metabolism*; D004852:Epoxy Compounds / Q000378:metabolism; D005229:Fatty Acids, Monounsaturated / Q000378:metabolism*; D005231:Fatty Acids, Unsaturated / Q000378:metabolism; D005260:Female; D007605:Juvenile Hormones / Q000096:biosynthesis*; D008297:Male; D008745:Methylation
chemical_list: D004852:Epoxy Compounds; D005229:Fatty Acids, Monounsaturated; D005231:Fatty Acids, Unsaturated; D007605:Juvenile Hormones; C058633:methyl 6,7-10,11-bis(epoxy)-3,7,11-trimethyl-2-dodecenoate; C007702:farnesoic acid