title: Abrupt augmentation of ST segment elevation associated with successful reperfusion: a sign of diminished myocardial salvage.
abstract: To investigate the significance of abrupt augmentation of ST segment elevation immediately after reperfusion, 36 patients with an initial acute anterior myocardial infarction successfully treated with thrombolysis were studied. Immediately after reperfusion was performed, 17 (47%) patients showed abrupt augmentation of ST segment elevation of anterior area (E group), and 19 (53%) patients did not (N group). The time to reperfusion was not significantly different between the two groups. In the E group the peak level of creatine kinase MB isozyme was higher (p < 0.05) than in the N group. The left ventricular ejection fraction (EF) did not increase in the E group from acute to chronic phase. However, in the N group EF increased significantly. The difference in EF in the chronic phase was significant between the two groups (p < 0.05). The infarcted regional wall motion (RWM) did not increase in the E group, whereas in the N group it increased markedly (p < 0.05). In addition, the infarcted RWM in the chronic phase was worse in the E group than in the N group (p < 0.05). Abrupt augmentation of ST segment elevation associated with successful reperfusion appears to reflect diminished myocardial salvage.
authors.affiliation: Department of Cardiovascular Medicine, School of Medicine, Hokkaido University, Sapporo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yokoshiki
authors.forename: T
authors.initials: T
authors.lastname: Kohya
authors.forename: K
authors.initials: K
authors.lastname: Tateda
authors.forename: T
authors.initials: T
authors.lastname: Shishido
authors.forename: K
authors.initials: K
authors.lastname: Hirasawa
authors.forename: A
authors.initials: A
authors.lastname: Kitabatake
mesh_terms: D000368:Aged; D003402:Creatine Kinase; D004562:Electrocardiography; D005260:Female; D006329:Heart Conduction System; D006801:Humans; D007527:Isoenzymes; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000201:enzymology / Q000503:physiopathology*; D013318:Stroke Volume; D015912:Thrombolytic Therapy
chemical_list: D007527:Isoenzymes; D003402:Creatine Kinase