title: Cardiovascular function during brain natriuretic peptide infusion in man.
abstract: To investigate the cardiovascular effects of pathophysiological levels of brain natriuretic peptide (BNP), 7 healthy subjects were submitted to equilibrium radionuclide angiocardiography in baseline conditions and during BNP infusion at increasing doses (4, 8, 10 and 12 pmol/kg.min for 20 min each). BNP induced a progressive, significant reduction in left ventricular end diastolic volume, stroke volume and end systolic volume and an increase in ejection fraction and heart rate. Cardiac output, arterial pressure and peripheral vascular resistance were unchanged. Activation of the sympathetic nervous system, as indicated by the significant increase in plasma norepinephrine levels, probably played a contributory role in the maintenance of cardiovascular homeostasis. These results indicate that BNP, at pathophysiological plasma concentrations, influences cardiovascular homeostasis in man.
authors.affiliation: Istituto di Medicine Interna, Università degli Studi di Firenze, Italia.
authors.forename: C
authors.initials: C
authors.lastname: Lazzeri
authors.forename: G
authors.initials: G
authors.lastname: La Villa
authors.forename: G
authors.initials: G
authors.lastname: Bisi
authors.forename: V
authors.initials: V
authors.lastname: Boddi
authors.forename: G
authors.initials: G
authors.lastname: Messeri
authors.forename: G
authors.initials: G
authors.lastname: Strazzulla
authors.forename: F
authors.initials: F
authors.lastname: Franchi
mesh_terms: D000328:Adult; D006152:Cyclic GMP / Q000097:blood; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D020097:Natriuretic Peptide, Brain; D009419:Nerve Tissue Proteins / Q000493:pharmacokinetics / Q000494:pharmacology*; D015635:Radionuclide Ventriculography; D016277:Ventricular Function, Left / Q000187:drug effects* / Q000502:physiology
chemical_list: D009419:Nerve Tissue Proteins; D020097:Natriuretic Peptide, Brain; D006152:Cyclic GMP