Clonidine-induced bradycardia.
Clonidine is an alpha-adrenergic agent that is used in the treatment of hypertension. Bradycardia has been described as a common effect of clonidine poisoning, but has rarely been described as a side effect at commonly prescribed dosages. Bradyarrhythmias, as a side effect, may have several manifestations and may be symptomatic or asymptomatic. This report proposes mechanisms for clonidine-induced bradycardia, describes persons at risk for this effect, and outlines treatments and preventive measures.
Golusinski
L L
LL
Department of Family and Preventive Medicine, Emory University School of Medicine, Atlanta, Georgia 30308, USA.
Blount
B W
BW
D000959:Antihypertensive Agents / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D001919:Bradycardia / Q000139:chemically induced*; D003000:Clonidine / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged
D000959:Antihypertensive Agents; D003000:Clonidine