title: Baseline and mitomycin C (MMC)-induced sister-chromatid exchanges in XX and XY cells of Callithrix jacchus chimeric twins.
abstract: Lymphocytes from chimeric individuals of the species Callithrix jacchus (Primates) were examined to evaluate differences in the frequency of sister chromatid exchanges (SCE) between XX and XY cells. The aim was to discover whether SCE differ according to genetic sex and whether XX and XY cells show a different sensitivity to SCE inducing agents. This experimental model has enabled us to eliminate the possible differences caused by environmental factors. The results obtained do not reveal significant differences between male and female cells, in either the baseline SCE frequency or that induced by mitomycin C at concentrations of 0.01 and 0.03 microgram/ml. No significant differences were observed in the distribution of high SCE frequency cells (HFC), even if it is possible to observe a higher level of exchanges in XX cells in each trial. With regard to the phenotypic sex, there appears to be a trend towards slightly higher SCE rates in females, even if results are not statistically significant.
authors.affiliation: Dipartimento di Biologia Animale-Laboratori di Antropologia, Università di Torino, Italy.
authors.forename: M P
authors.initials: MP
authors.lastname: Bigatti
authors.forename: L
authors.initials: L
authors.lastname: Lambert
authors.forename: S
authors.initials: S
authors.lastname: Crovella
authors.forename: G
authors.initials: G
authors.lastname: Ardito
mesh_terms: D000818:Animals; D002144:Callithrix; D002478:Cells, Cultured; D002678:Chimera; D005260:Female; D008214:Lymphocytes / Q000166:cytology* / Q000187:drug effects; D008297:Male; D016685:Mitomycin / Q000633:toxicity*; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects; D014427:Twins
chemical_list: D009153:Mutagens; D016685:Mitomycin