title: Parathyroid hormone-related peptide expression in endocrine tumors.
abstract: Parathyroid hormone-related peptide (PTHrP) expression is associated with the histological type in pituitary tumor, but not in thyroid carcinoma. However invasive and metastatic tumors showed intense PTHrP staining in both pituitary and thyroid tumors. Analysis of the established metastatic rat pituitary tumor cell line showed that PTHrP plays a crucial role in in vivo cell proliferation closely related to worsening of malignant transformation and neovascularization in a paracrine fashion.
authors.affiliation: First Department of Internal Medicine, Nagasaki University School of Medicne, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Nagataki
authors.forename: M
authors.initials: M
authors.lastname: Nakashima
authors.forename: K
authors.initials: K
authors.lastname: Akino
authors.forename: A
authors.initials: A
authors.lastname: Ohtsuru
authors.forename: H
authors.initials: H
authors.lastname: Namba
authors.forename: T
authors.initials: T
authors.lastname: Kiriyama
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: I
authors.initials: I
authors.lastname: Sekine
authors.forename: S
authors.initials: S
authors.lastname: Yamashita
mesh_terms: D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000378:metabolism; D004701:Endocrine Gland Neoplasms / Q000378:metabolism*; D006801:Humans; D009363:Neoplasm Proteins / Q000096:biosynthesis*; D010281:Parathyroid Hormone / Q000096:biosynthesis*; D044162:Parathyroid Hormone-Related Protein; D010911:Pituitary Neoplasms / Q000378:metabolism; D014176:Protein Biosynthesis; D013964:Thyroid Neoplasms / Q000378:metabolism
chemical_list: D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein