Study of local anesthetics. Part 128. HPLC study of the degradation of heptacaine and carbisocaine in urine, human and rabbit serums.
A HPLC method is described for the simultaneous determination of the phanylcarbamate type anesthetics heptacaine and carbisocaine and their metabolites. Using this method the in vitro degradation of these drugs in urine, human and rabbit serums was investigated. The slower degradation of carbisocaine was explained on the basis of steric hindrance.
Lehotay
J
J
Department of Analytical Chemistry, Faculty of Chemical Technology, Slovak Technical University.
Cizmárik
J
J
Brandsteterová
E
E
D000779:Anesthetics, Local / Q000652:urine*; D000818:Animals; D001673:Biodegradation, Environmental; D002219:Carbamates / Q000652:urine*; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D006801:Humans; D007202:Indicators and Reagents; D010880:Piperidines / Q000652:urine*; D011817:Rabbits
D000779:Anesthetics, Local; D002219:Carbamates; D007202:Indicators and Reagents; D010880:Piperidines; C013549:heptacaine; C046030:carbizocaine