title: "Physiologic" intracellular acidosis in pregnancy.
abstract: To investigate acid-base homeostasis in pregnancy, we used phosphorus 31 nuclear magnetic resonance spectroscopy to measure intracellular pH in erythrocytes from nonpregnant (n = 33) and third-trimester pregnant women (n = 22). Intracellular pH was lower in pregnant compared with nonpregnant controls (7.23 +/- 0.015 vs 7.29 +/- 0.012, p = 0.003). We hypothesize that this "physiologic" intracellular acidosis of pregnancy potentiates oxygen-hemoglobin dissociation and oxygen delivery across the placenta.
authors.affiliation: Department of Internal Medicine, Wayne State University School of Medicine, Detroit, MI 48201, USA.
authors.forename: O
authors.initials: O
authors.lastname: Bardicef
authors.forename: M
authors.initials: M
authors.lastname: Bardicef
authors.forename: Y
authors.initials: Y
authors.lastname: Sorokin
authors.forename: D B
authors.initials: DB
authors.lastname: Cotton
authors.forename: L M
authors.initials: LM
authors.lastname: Resnick
mesh_terms: D000136:Acid-Base Equilibrium / Q000502:physiology*; D044383:Black People; D004912:Erythrocytes; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006706:Homeostasis; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy; D010100:Oxygen / Q000097:blood; D010920:Placenta / Q000378:metabolism; D011247:Pregnancy / Q000502:physiology*; D044465:White People
chemical_list: D006454:Hemoglobins; D010100:Oxygen