title: A histomorphologic study of explants of massive allografts: preliminary results.
abstract: The authors report their experience in the histologic study of massive allografts, explanted as a result of oncological, mechanical or biological complications. The study was conducted according to the method of inclusion in methyl methacrylate that does not involve decalcification. A description is provided of all of the phases of fusion between graft and host bone in the site of the osteotomies, as well as distribution of revascularization and rehabilitation of the graft, attachment of the soft tissues, and finally, modifications in the joint cartilage of the osteoarticular grafts. The allograft must be considered to be osteoconductive, and is only weakly osteoinductive. Incorporation of the graft is a slow and incomplete process that follows sequential phases. The Volkmann's canals in the osteotomies constitute the preferred paths for rehabilitation of the graft that is on the order of millimeters on the surface and centimeters in the site of the osteotomies. The greatest modifications have been observed in the joint cartilage. The cartilaginous cells appear to be vital only from a morphological point of view.
authors.affiliation: Laboratorio di Ricerca Oncologica, Istituto Ortopedico Rizzoli, Bologna.
authors.forename: P
authors.initials: P
authors.lastname: Caldroa
authors.forename: D
authors.initials: D
authors.lastname: Donati
authors.forename: R
authors.initials: R
authors.lastname: Capanna
authors.forename: M
authors.initials: M
authors.lastname: Di Liddo
authors.forename: M S
authors.initials: MS
authors.lastname: Benassi
authors.forename: D A
authors.initials: DA
authors.lastname: Campanacci
authors.forename: L
authors.initials: L
authors.lastname: Sangiorgi
authors.forename: M
authors.initials: M
authors.lastname: Zavatta
authors.forename: P
authors.initials: P
authors.lastname: Picci
mesh_terms: D000293:Adolescent; D000328:Adult; D001174:Arthrodesis; D016025:Bone Transplantation / Q000009:adverse effects; D001842:Bone and Bones / Q000033:anatomy & histology*; D002358:Cartilage, Articular; D002648:Child; D002675:Child, Preschool; D005500:Follow-Up Studies; D006801:Humans; D008768:Methylmethacrylates; D010027:Osteotomy; D011183:Postoperative Complications; D013997:Time Factors; D014184:Transplantation, Homologous
chemical_list: D008768:Methylmethacrylates