title: [In vitro activity of six beta-lactams against 295 strains of enterobacteriaceae and P. aeruginosa isolated from neutropenic patients].
abstract: The in vitro activity of two new beta-lactam agents, cefpirome (CPO) and cefepime (FEP), was investigated against 295 Gram-negative bacilli (250 enterobacteriaceae and 45 P. aeruginosa) isolated from neutropenic patients. They were compared with ceftazidime (CAZ), piperacillin-tazobactam (TZP), imipenem (IPM) and cefotaxime (CTX). All enterobacteriacae were susceptible to IPM, 16 strains were intermediately susceptible or resistant to CAZ (1 strain of E. coli, 4 of Morganella morganii and 11 of Enterobacter. The 250 strains of enterobacteriacea were susceptible to FEP (MIC < 1 mg/l) and only one strain among them was intermediately susceptible to CPO. Among 45 strains of P. aeruginosa, 21 strains were susceptible to CPO, 30 to FEP, 31 to TZP, 32 to CAZ and 34 to IPM. All the strains were inhibited by less than 32 mg/l of FEP and IPM.
authors.affiliation: Laboratoire de Bactériologie, Hôpital Haut Lévêque, Pessac, France.
authors.forename: J
authors.initials: J
authors.lastname: Maugein
authors.forename: F
authors.initials: F
authors.lastname: Perrier
authors.forename: P
authors.initials: P
authors.lastname: Cony Makhoul
authors.forename: J
authors.initials: J
authors.lastname: Fourche
authors.forename: V
authors.initials: V
authors.lastname: Darmaillac
mesh_terms: D000077723:Cefepime; D002439:Cefotaxime / Q000494:pharmacology; D002442:Ceftazidime / Q000494:pharmacology; D002511:Cephalosporins / Q000494:pharmacology*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects* / Q000302:isolation & purification; D006801:Humans; D015378:Imipenem / Q000494:pharmacology; D066298:In Vitro Techniques; D009503:Neutropenia / Q000382:microbiology*; D010397:Penicillanic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D010878:Piperacillin / Q000494:pharmacology; D011550:Pseudomonas aeruginosa / Q000187:drug effects* / Q000302:isolation & purification; D000078142:Tazobactam; D013845:Thienamycins / Q000494:pharmacology; D000097572:Cefpirome
chemical_list: D000077723:Cefepime; D002439:Cefotaxime; D002442:Ceftazidime; D002511:Cephalosporins; D015378:Imipenem; D010397:Penicillanic Acid; D010406:Penicillins; D010878:Piperacillin; D000078142:Tazobactam; D013845:Thienamycins; D000097572:Cefpirome
vernacular_title: Activité in vitro de six beta-lactamines vis-à-vis de 295 souches d'entérobactéries et P. aeruginosa isolées chez des patients neutropéniques.