Treatment of visceral leishmaniasis in a patient with AIDS with antimony and gamma-interferon: remission and prevention of relapse by maintenance therapy with weekly pentamidine.
A 41-year-old AIDS patient with fever, nightly perspiration, diarrhoea, anaemia and leukopenia was diagnosed as having visceral leishmaniasis (VL). After 8 weeks of antimony treatment combined with gamma-interferon, given in 2 courses of 3 and 5 weeks, 12 weeks apart, the bone marrow revealed no parasites by microscopy and culture. Parasitic DNA could still be demonstrated by polymerase chain reaction. Weekly intravenous pentamidine maintenance therapy seemed to prevent relapses. Over time the patient was treated for disseminated M. avium infection, CMV retinitis, porphyria cutanea tarda and renal tubular acidosis. Ultimately he succumbed, 2.5 years after the diagnosis of VL and 4.5 years after the diagnosis of AIDS was established.
Lustig
V
V
Department of Internal Medicine, Slotervaart Hospital, Amsterdam, Netherlands.
Kager
P A
PA
Meenhorst
P L
PL
D017088:AIDS-Related Opportunistic Infections / Q000175:diagnosis / Q000628:therapy*; D000328:Adult; D000965:Antimony / Q000627:therapeutic use*; D000981:Antiprotozoal Agents / Q000627:therapeutic use*; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D006801:Humans; D007371:Interferon-gamma / Q000627:therapeutic use*; D007898:Leishmaniasis, Visceral / Q000175:diagnosis / Q000628:therapy*; D008297:Male; D010419:Pentamidine / Q000627:therapeutic use*
D000981:Antiprotozoal Agents; D010419:Pentamidine; D007371:Interferon-gamma; D000965:Antimony