[The chronic action of large doses of aluminum on nervous and cardiac activities in rats administered it intramuscularly].
The influence of high doses of aluminium chloride on the central nervous system and regulation of the heart activity in 12 rats of Wistar line (6 experimental and 6 control animals) at intramuscular injection during 10 days was studied. Changes in animals behaviour as well as variations in electroencephalogram (EEC) in the form of paroxysmal activity and the increase of capacity in beta 1.2 EEG spectra of sensomotor cortex and beta 2 EEG spectrum of optic cortex were observed within 2-3 days after daily injection of AlCl3 in the dose of 400 mg/kg. These changes in behaviour and EEG as well as the results of morphological and biochemical research obtained in other works indicated that aluminium influenced mainly on the central nervous system. Further accumulation of AlCl3 as the result of daily injection of effective dose (400 mg/kg) during the following 7-8 days took place without marked increase of physiological changes but led to the death of 50% of animals studied pointing to LD50 value for 10 days, approximately equal to 400 mg/kg per day (total dose was 4.0 g/kg), and the large latent period and cumulative nature of aluminium chloride effect. Aluminium influence on the rhythm of the heart activity to the point of death was not revealed pointing to relative stability of the peripheral nervous system to the toxic action of aluminium.
Titkov
E S
ES
Oganesian
G A
GA
D000077410:Aluminum Chloride; D017607:Aluminum Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D002712:Chlorides / Q000008:administration & dosage / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects / Q000295:instrumentation; D004567:Electrodes, Implanted; D004569:Electroencephalography / Q000187:drug effects / Q000295:instrumentation; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D007273:Injections, Intramuscular; D009420:Nervous System / Q000187:drug effects*; D009424:Nervous System Physiological Phenomena; D051381:Rats; D017208:Rats, Wistar; D012815:Signal Processing, Computer-Assisted; D013997:Time Factors
D017607:Aluminum Compounds; D002712:Chlorides; D000077410:Aluminum Chloride
Izuchenie khronicheskogo deĭstviia bol'shikh doz aliuminiia na nervnuiu i serdechnuiu deiatel'nost' krys pri vnutrimyshechnom vvedenii.