Determination of triamcinolone acetonide in equine serum and urine by liquid chromatography-atmospheric pressure ionization mass spectrometry.
Urine and serum samples collected from four standard-bred mares after 30-mg intraarticular administrations of triamcinolone acetonide were analyzed using combined high-performance liquid chromatography-atmospheric pressure ionization mass spectrometry. Maximum triamcinolone acetonide concentrations of 32.3, 14.8, 24.3, and 29.4 ng/mL in the urine and 2.7, 1.9, 2.3, and 2.5 ng/mL in the serum samples were observed. The peak concentrations of the drug were detected approximately 22 h (urine) and 12 h (serum) after administration. The drug elimination profiles for both urine and serum are presented and discussed.
Koupai-Abyazani
M R
MR
Can Test Laboratories Ltd., Vancouver, BC, Canada.
Yu
N
N
Esaw
B
B
Laviolette
B
B
D000818:Animals; D002851:Chromatography, High Pressure Liquid; D006736:Horses; D013058:Mass Spectrometry; D014222:Triamcinolone Acetonide / Q000097:blood* / Q000652:urine*
D014222:Triamcinolone Acetonide