Truncated and catalytic isoforms of trkB are co-expressed in neurons of rat and mouse CNS.
Localization of mRNA encoding trkB indicates that two truncated isoforms of trkB, T1trkB and T2trkB, are differentially distributed in the rodent nervous system, and that each of these transcripts is co-expressed with catalytic trkB (TK+trkB) in adult motor neurons. In contrast to the prominent expression of T1trkB by non-neuronal cells, T2trkB expression appeared to be restricted to neurons and demonstrated significant overlap with the pattern of TK+trkB distribution. In developing spinal cord ventral horn, an age-related increase in hybridization was observed for truncated isoforms. These findings suggest that truncated trkB may modulate neuronal responses to neurotrophins which act via trkB.
Armanini
M P
MP
Department of Neuroscience, Genentech Inc., CA 94080, USA.
McMahon
S B
SB
Sutherland
J
J
Shelton
D L
DL
Phillips
H S
HS
D000375:Aging / Q000378:metabolism; D000818:Animals; D001345:Autoradiography; D001483:Base Sequence; D002490:Central Nervous System / Q000378:metabolism*; D004622:Embryo, Mammalian / Q000378:metabolism; D017403:In Situ Hybridization; D007536:Isomerism; D051379:Mice; D015335:Molecular Probes / Q000235:genetics; D008969:Molecular Sequence Data; D009046:Motor Neurons / Q000378:metabolism; D009474:Neurons / Q000378:metabolism*; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D020801:Receptor, Ciliary Neurotrophic Factor; D017475:Receptors, Nerve Growth Factor / Q000737:chemistry / Q000235:genetics / Q000378:metabolism*
D015335:Molecular Probes; D012333:RNA, Messenger; D020801:Receptor, Ciliary Neurotrophic Factor; D017475:Receptors, Nerve Growth Factor