[The activity of the glutathione antioxidative system in the blood of patients with acute nonepidemic parotitis].
Activities of glucose-6-phosphate dehydrogenase (G-6-PDH) and malate dehydrogenase were measured in the blood of 38 patients with acute nonepidemic parotitis and the status of glutathione antioxidant system assessed. The predominance of free-radical processes in the mechanisms of impairment of the parotid gland was confirmed. Increased level of lipid peroxidation products and decompensation of glutathione antioxidant system were found to be due to incompetence of the malate shuttle and low activity of G-6-PDH. A conclusion is made about the necessity of revising current approaches to prevention and therapy of acute nonepidemic parotitis.
Dolgov
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Filipenko
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PS
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000975:Antioxidants; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005978:Glutathione / Q000097:blood*; D006801:Humans; D015227:Lipid Peroxidation; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010195:Pancreatitis / Q000097:blood; D010309:Parotitis / Q000097:blood*
D000975:Antioxidants; D008315:Malondialdehyde; D005954:Glucosephosphate Dehydrogenase; D005978:Glutathione
Aktivnost' antioksilitel'noĭ sistemy glutationa v krovi bol'nykh s ostrym neépidemicheskim parotitom.