title: [Treatment using concomitant radiochemotherapy of N+ M0 stage urothelial tumors of the bladder].
abstract: Seventeen patients with N+ urothelial bladder tumours were treated by a combination of deep endoscopic resection and concomitant radiochemotherapy (5FU cisplatin). 15 patients completed their course of treatment. 52.9% of these 17 patients are in complete remission at 6 months, 35.2% are in complete remission at 1 year, 30% of patients in complete remission developed distant metastases, 52.9% developed local progression and 40% developed distant metastases. This protocol of deep resection combined with radiochemotherapy can therefore be effective in the local control of the tumour and can allow preservation of the bladder in the case of complete remission. However, it is insufficient to prevent the development of distant metastases. It is therefore preferable to intensify this treatment by performing complete endoscopic resection, by increasing the radiotherapy dose rate and by intensifying the chemotherapy protocol.
authors.affiliation: Service d'Urologie, Hôpital de Bicêtre, Le Kremlin Bicêtre.
authors.forename: G
authors.initials: G
authors.lastname: Benoit
authors.forename: M
authors.initials: M
authors.lastname: Di Palma
authors.forename: P
authors.initials: P
authors.lastname: Blanchet
authors.forename: S
authors.initials: S
authors.lastname: Lecouturier
authors.forename: Y
authors.initials: Y
authors.lastname: Yataghene
authors.forename: Y
authors.initials: Y
authors.lastname: Decroix
authors.forename: J L
authors.initials: JL
authors.lastname: Misset
authors.forename: A
authors.initials: A
authors.lastname: Jardin
mesh_terms: D000328:Adult; D000368:Aged; D000964:Antimetabolites, Antineoplastic / Q000008:administration & dosage / Q000009:adverse effects; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects; D018450:Disease Progression; D004724:Endoscopy; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D011879:Radiotherapy Dosage; D018714:Radiotherapy, Adjuvant; D012074:Remission Induction; D001749:Urinary Bladder Neoplasms / Q000188:drug therapy / Q000473:pathology / Q000532:radiotherapy / Q000601:surgery*
chemical_list: D000964:Antimetabolites, Antineoplastic; D000970:Antineoplastic Agents; D002945:Cisplatin; D005472:Fluorouracil
vernacular_title: Traitement par radiochimiothérapie concomitante des tumeurs urothéliales de vessie N+ M0.