[Pharmacokinetics and bioavailability of glipizide capsules].
The pharmacokinetics and bioavailability of glipizide were studied in 8 healthy male volunteers after a single oral dose of 5 mg in capsule or in tablet. The plasma levels of glipizide were assayed by high performance liquid chromatography. The concentration--time curves of both preparations were fitted to a one compartment model. The pharmacokinetic parameters of glipizide in capsule and in tablet were shown in tables 2 and 3. The relative bioavailability of the capsule was 109.9% compared with the tablet.
Chen
Q C
QC
Zhongshan Hospital of Shanghai.
Yang
C Q
CQ
Chao
C H
CH
Ma
Y G
YG
Li
X N
XN
Chen
W L
WL
D000328:Adult; D001682:Biological Availability; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D005913:Glipizide / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male
D002214:Capsules; D005913:Glipizide