title: Thyroid scintigraphy and perchlorate discharge test in the diagnosis of congenital hypothyroidism.
abstract: Quantitative thyroid scanning using low doses of technetium-99m sodium pertechnetate was performed on 147 infants (55 males and 92 females) with congenital hypothyroidism detected through the national neonatal screening programme. Thirty-two (21.8%) were athyrotic, while 62 (42.2%) had an ectopic thyroid and 53 (36%) had a eutopic gland with increased 99mTc uptake (mean 17%; range, 5%-38%). The perchlorate discharge test (PDT) was performed in nine of the infants with ectopic glands and 15 with eutopic glands; the findings were consistent with an organification defect in 22 cases (seven ectopic and 15 eutopic). Thyroid scintigraphy and PDT can add useful aetiological, genetic and prognostic information in the clinical evaluation of infants with congenital hypothyroidism detected by neonatal screening.
authors.affiliation: Department of Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
authors.forename: M
authors.initials: M
authors.lastname: el-Desouki
authors.forename: N
authors.initials: N
authors.lastname: al-Jurayyan
authors.forename: A
authors.initials: A
authors.lastname: al-Nuaim
authors.forename: A
authors.initials: A
authors.lastname: al-Herbish
authors.forename: A
authors.initials: A
authors.lastname: Abo-Bakr
authors.forename: Y
authors.initials: Y
authors.lastname: al-Mazrou
authors.forename: A
authors.initials: A
authors.lastname: al-Swailem
mesh_terms: D002828:Choristoma / Q000000981:diagnostic imaging; D003409:Congenital Hypothyroidism; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000000981:diagnostic imaging* / Q000517:prevention & control; D007231:Infant, Newborn; D007457:Iodine Radioisotopes; D008297:Male; D015997:Neonatal Screening; D010472:Perchlorates; D017680:Potassium Compounds; D011877:Radionuclide Imaging; D013670:Sodium Pertechnetate Tc 99m; D013960:Thyroid Function Tests; D013961:Thyroid Gland / Q000002:abnormalities / Q000000981:diagnostic imaging
chemical_list: D007457:Iodine Radioisotopes; D010472:Perchlorates; D017680:Potassium Compounds; C009006:potassium perchlorate; D013670:Sodium Pertechnetate Tc 99m