Cervical fetal fibronectin correlates to cervical ripening.
OBJECTIVE
It is well established that the cervical ripeness is of great prognostic value at labor induction. The available methods of measuring the cervical ripeness are not satisfactory. This study was therefore initiated to investigate if there is any correlation between cervical fetal fibronectin and cervical ripening at term.


METHODS
Three groups were included in this study: women with unripe cervices, women with spontaneous cervical ripening and those with PGE2-induced cervical ripening. Fetal fibronectin was measured by ELIZA after sampling from the cervical canal.


RESULTS
The cervical fetal fibronectin was low in women with unripe cervices. In women with favorable cervices a ten fold higher level was found. The fibronectin level was even higher after PGE2-induced ripening.


CONCLUSIONS
Conclusively an increased amount of cervical fetal fibronectin is registered during the cervical ripening process. A level of > 0.80 microgram/ml of cervical fetal fibronectin seems to indicate a favorable cervix.
Ekman
G
G
Department of Obstetrics and Gynaecology, Karolinska Hospital, Stockholm, Sweden.
Granström
L
L
Malmström
A
A
Sennström
M
M
Svensson
J
J
D000328:Adult; D002584:Cervix Uteri / Q000737:chemistry / Q000187:drug effects / Q000502:physiology*; D015232:Dinoprostone / Q000008:administration & dosage* / Q000494:pharmacology; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D005353:Fibronectins / Q000032:analysis*; D005865:Gestational Age; D006801:Humans; D007751:Labor, Induced / Q000379:methods; D010120:Oxytocics / Q000008:administration & dosage / Q000494:pharmacology; D011247:Pregnancy; D011263:Pregnancy Trimester, Third; D016216:Ultrasonography, Prenatal
D005353:Fibronectins; D010120:Oxytocics; D015232:Dinoprostone