title: [Utility of electrophysiologic study using the blink reflex and brainstem evoked potentials for the evaluation of the course of uremic polyneuropathy].
abstract: On the present study the authors evaluate the utility of electrophysiologic examination in uraemic polyneuropathy. A group of 19 uraemic patients in chronic dialysis underwent the Blink reflex and BAEPSs study to evaluate the alterations of nervous pathways. The results obtained were compared with those of a group of 10 healthy patients comparable for age and sex. The electrophysiologic parameters have been statistically compared with the plasma levels of vit. B12. folic acid, PTH and beta-2-microglobulin. The results show a significant difference of uremic patients compared with the healthy ones for the Blink reflex (ipsilateral and contralateral R2 responses). Also BAEPSs show significant alterations in the uraemic group (latencies of the III, V components). A statistically significantly inverse correlation is present between folic acid values and blink reflex R1 and R2 responses. Therefore our study shows the existence of a combined degeneration of central and peripheral nervous pathways in chronic uraemic patients. We believe that the decrease in folic acid concentration found in our study may be one of the causes of the beginning and then of the worsening of neurologic damage.
authors.affiliation: Unità Operativa di Nefrologia e Dialisi, Istituto Geriatrico U. Sestilli, INRCA, Ancona.
authors.forename: S
authors.initials: S
authors.lastname: Baldini
authors.forename: R
authors.initials: R
authors.lastname: Radicioni
authors.forename: M
authors.initials: M
authors.lastname: Melappioni
authors.forename: M
authors.initials: M
authors.lastname: Baldassari
authors.forename: N
authors.initials: N
authors.lastname: Panichi
authors.forename: G
authors.initials: G
authors.lastname: Pelliccioni
authors.forename: M
authors.initials: M
authors.lastname: Guidi
authors.forename: L
authors.initials: L
authors.lastname: Rosa
authors.forename: R
authors.initials: R
authors.lastname: Magnaterra
authors.forename: O
authors.initials: O
authors.lastname: Scarpino
mesh_terms: D000328:Adult; D000368:Aged; D001767:Blinking; D018450:Disease Progression; D016057:Evoked Potentials, Auditory, Brain Stem; D005260:Female; D005492:Folic Acid / Q000097:blood; D005494:Folic Acid Deficiency / Q000150:complications* / Q000209:etiology; D006801:Humans; D008297:Male; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood; D010523:Peripheral Nervous System Diseases / Q000097:blood / Q000209:etiology* / Q000503:physiopathology; D012021:Reflex, Abnormal; D006435:Renal Dialysis / Q000009:adverse effects*; D014511:Uremia / Q000097:blood / Q000150:complications* / Q000503:physiopathology / Q000628:therapy; D014805:Vitamin B 12 / Q000097:blood; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D010281:Parathyroid Hormone; D001613:beta 2-Microglobulin; D005492:Folic Acid; D014805:Vitamin B 12
vernacular_title: Utilità dello studio elettrofisiologico mediante blink reflex e potenziali evocati del tronco encefalico (BAEPS), per la valutazione dell'evoluzione della polineuropatia uremica.