Comparison of fosfomycin and teicoplanin in serum bactericidal activity against staphylococci.
A serum bactericidal test was established employing human sera of volunteers after intravenous administration of fosfomycin (CAS 23155-02-4) and teicoplanin (CAS 61036-62-2) against 40 staphylococcal strains (20 Staphylococcus aureus and 20 coagulase-negative staphylococci, 10 of each group being susceptible and 10 being resistant to oxacillin). Median serum inhibitory titres were highest for fosfomycin against oxacillin-susceptible Staphylococcus aureus. In the three other groups of strains, the activity of fosfomycin was comparable to that of teicoplanin. The killing curves showed over 99% killing within 24 h for both antibiotics. Here, fosfomycin exerted a rapid killing activity within 4-6 h and was more effective in bacterial growth reduction. It can be concluded that fosfomycin and teicoplanin exerted comparable serum bactericidal antibacterial activity against staphylococci.
Vogt
K
K
Department of Medical Microbiology, Rudolf Virchow University Hospital, Berlin, Germany.
Rauhut
A
A
Trautmann
M
M
Hahn
H
H
D000328:Adult; D000900:Anti-Bacterial Agents / Q000493:pharmacokinetics / Q000494:pharmacology*; D005578:Fosfomycin / Q000493:pharmacokinetics / Q000494:pharmacology*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D010068:Oxacillin / Q000494:pharmacology; D010406:Penicillins / Q000494:pharmacology; D015610:Serum Bactericidal Test; D013211:Staphylococcus aureus / Q000187:drug effects*; D017334:Teicoplanin / Q000493:pharmacokinetics / Q000494:pharmacology*; D018440:beta-Lactam Resistance
D000900:Anti-Bacterial Agents; D010406:Penicillins; D005578:Fosfomycin; D017334:Teicoplanin; D010068:Oxacillin