Structure-activity correlationship and strain specificity of polyoxometalates in anti-human immunodeficiency virus activity.
The anti-human immunodeficiency virus (HIV) activity of polyoxometalates of representative structural families, such as Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich, was determined using two strains of HIV type 1 (HIV-1HTLV-IIIB and HIV-1SF-2H). The compounds were preferably selected to cover both polyoxotungstates and polyoxomolybdates in each structural family. In general, polyoxotungstates of Keggin, lacunary Keggin, trivacant Keggin, Keggin sandwich, Wells-Dawson and Wells-Dawson sandwich structures showed anti-HIV-1HTLVIIIB activity, whereas most compounds not included in these structural categories were inactive. Among the compounds with a potent anti-HIV-1HTLV-IIIB activity, those of Keggin and its closely related structural families (lacunary Keggin, trivacant Keggin and Keggin sandwich) inhibited the cytopathogenicity and syncytium formation caused by HIV-1SF-2 to a much higher extent compared with HIV-1HTLV-IIIB-related ones. The difference between the spectra of anti-HIV-1HTLV-IIIB activity and the specificity for HIV-1SF-2H might result from differential structural requirements in these functions.
Inouye
Y
Y
Institute of Pharmaceutical Sciences, Hiroshima University School of Medicine, Japan.
Fujimoto
Y
Y
Sugiyama
M
M
Yoshida
T
T
Yamase
T
T
D000998:Antiviral Agents / Q000494:pharmacology*; D002478:Cells, Cultured; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects; D019085:Fluorescent Antibody Technique, Direct; D015497:HIV-1 / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008982:Molybdenum / Q000494:pharmacology*; D013045:Species Specificity; D013329:Structure-Activity Relationship; D017973:Tungsten Compounds / Q000494:pharmacology*; D017968:Vanadium Compounds / Q000494:pharmacology*; D014764:Viral Proteins / Q000096:biosynthesis
D000998:Antiviral Agents; D017973:Tungsten Compounds; D017968:Vanadium Compounds; D014764:Viral Proteins; D008982:Molybdenum