Cytotoxic activity of diorganotin(IV) complexes of some xanthate derivatives.
The cytotoxic activities of diorganotin(IV) complexes of some xanthate derivatives; R2Sn(SSCOR'), where R = Me, Bu(n), Ph and R' = C6H11 - (CyX), CH3NHCHCH2 - (MAEX), (CH3)2NCH2CH2 - (DMAEX), (CH3)2NCH2CH(CH3) - (DMAIX) and (C2H5)2NCH2CH2 - (DEAEX), have been studied against Hep-2, Hela, RD, L20B and BGM cell lines using the MTT-colorimetric assay. The present results indicated that moderate activities were demonstrated by the xanthate complexes of Bu(n)2Sn(IV) against four cell lines, whereas no cytotoxic activities were exhibited by both Me2Sn(IV) and Ph2Sn(IV) complexes of the xanthates. These activities were compared with the cytotoxic activities of two reference standards; the cisplatin and paraplatin complexes. The significance of these results is discussed.
Rashan
L J
LJ
Department of Biology, College of Education, University of Mosul, Iraq.
al-Allaf
T A
TA
Khuzaie
R F
RF
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009947:Organotin Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D013871:Thiones / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009947:Organotin Compounds; D013871:Thiones; C004918:ethylxanthate