title: Variations in the formation of the human caudal spinal cord.
abstract: Collection of 15 human embryos between 4-8 developmental weeks was used to histologically investigate variations in the development of the caudal part of the spinal cord and the neighboring axial organs (notochord and vertebral column). In the 4-week embryo, two types of neurulation were parallelly observed along the anteroposterior body axis: primary in the areas cranial to the neuroporus caudalis and secondary in the more caudal tail regions. In the 5-week embryos, both parts of the neural tube fused, forming only one continuous lumen in the developing spinal cord. In the three examined embryos we found anomalous pattern of spinal cord formation. Caudal parts of these spinal cords displayed division of their central canal into two or three separate lumina, each surrounded by neuroepithelial layer. In the caudal area of the spinal cord, derived by secondary neurulation, formation of separate lumina was neither connected to any anomalous notochord or vertebral column formation, nor the appearance of any major axial disturbances. We suggest that development of the caudal part of the spinal cord differs from its cranial region not only in the type of neurulation, but also in the destiny of its derivatives and possible modes of abnormality formation.
authors.affiliation: Department of Histology and Embryology, School of Medicine--Split Branch, University of Zagreb, Croatia.
authors.forename: M
authors.initials: M
authors.lastname: Saraga-Babić
authors.forename: D
authors.initials: D
authors.lastname: Sapunar
authors.forename: J
authors.initials: J
authors.lastname: Wartiovaara
mesh_terms: D000029:Abortion, Legal; D004622:Embryo, Mammalian; D005314:Embryonic and Fetal Development; D005260:Female; D006801:Humans; D009672:Notochord / Q000166:cytology / Q000502:physiology; D011247:Pregnancy; D013116:Spinal Cord / Q000166:cytology / Q000196:embryology*; D013131:Spine / Q000166:cytology / Q000196:embryology