The expression of the imprinted H19 and IGF-2 genes in human bladder carcinoma.
The imprinted H19 gene is highly expressed in human embryos, fetal tissues and is nearly completely shut off in adults. However, it is reexpressed in a number of tumors including bladder carcinoma, demonstrating that H19 RNA is an oncofetal RNA. Tumors induced by injection of bladder carcinoma cell lines express H19 in contrast to the cells before injection. These observations support the notion of a positive correlation between H19 expression and bladder carcinoma. Loss of imprinting of H19 and IGF-2 was observed in samples of human bladder carcinoma.
Elkin
M
M
Department of Biological Chemistry, Silberman Institute of Life Sciences, Hebrew University, Jerusalem, Israel.
Shevelev
A
A
Schulze
E
E
Tykocinsky
M
M
Cooper
M
M
Ariel
I
I
Pode
D
D
Kopf
E
E
de Groot
N
N
Hochberg
A
A
D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D005260:Female; D015972:Gene Expression Regulation, Neoplastic; D018392:Genomic Imprinting; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000235:genetics*; D051379:Mice; D008819:Mice, Nude; D008969:Molecular Sequence Data; D009124:Muscle Proteins / Q000235:genetics*; D009368:Neoplasm Transplantation; D062085:RNA, Long Noncoding; D012333:RNA, Messenger / Q000378:metabolism; D012334:RNA, Neoplasm / Q000378:metabolism; D022661:RNA, Untranslated; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D017931:DNA Primers; C094335:H19 long non-coding RNA; D009124:Muscle Proteins; D062085:RNA, Long Noncoding; D012333:RNA, Messenger; D012334:RNA, Neoplasm; D022661:RNA, Untranslated; D007335:Insulin-Like Growth Factor II