title: Solitary giant xanthogranuloma and benign cephalic histiocytosis--variants of juvenile xanthogranuloma.
abstract: Sequential biopsies taken from a patient with a solitary giant xanthogranuloma, an exaggerated macronodular (> 5 cm in diameter) variant of juvenile xanthogranuloma, and from a patient with benign cephalic histiocytosis, revealed a characteristic time sequence of histopathological findings. Early stages of the diseases showed a monomorphous infiltrate of mononuclear vacuolated histiocytes positive for KiM1p, HAM56 and factor XIIIa and were characterized by clusters of comma-shaped bodies. This was followed by a polymorphous mixture of various mononuclear and multinucleate histiocytes additionally labelling with KP1 (CD68) and, in occasional cells, for the adherence of peanut agglutinin. A variety of ultrastructural changes were found, including dense and regularly laminated bodies or lipid droplets. Our findings indicate that both entities are variants of a xanthogranulomatous reaction.
authors.affiliation: Department of Pathology, University of Innsbruck, Austria.
authors.forename: B G
authors.initials: BG
authors.lastname: Zelger
authors.forename: B
authors.initials: B
authors.lastname: Zelger
authors.forename: H
authors.initials: H
authors.lastname: Steiner
authors.forename: G
authors.initials: G
authors.lastname: Mikuz
mesh_terms: D000906:Antibodies; D000911:Antibodies, Monoclonal; D006644:Histiocytes / Q000648:ultrastructure; D015614:Histiocytosis / Q000145:classification / Q000378:metabolism / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007223:Infant; D008297:Male; D012867:Skin / Q000737:chemistry / Q000648:ultrastructure*; D014972:Xanthogranuloma, Juvenile / Q000145:classification / Q000378:metabolism / Q000473:pathology*
chemical_list: D000906:Antibodies; D000911:Antibodies, Monoclonal