The inhibitory effect of the crude extract from a seaweed of Dygenea simplex C. Agardh on the in vitro cytopathic activity of HIV-1 and it's antigen production.
The crude water extract (NS-1) from a seaweed (Digenea simplex C. Agardh Rhodomelaceae) exhibited anti-human immunodeficiency virus (HIV)-1 activity in vitro. The inhibitory effect of the extract on the cytopathic activity of HIV-1 and it's antigen production was examined using a microplate method, immunofluorescent assay, and an HIV antigen detection kit (Abbott). NS-1 inhibited both the cytopathic effect of HIV-1 to MT-4 cells and the giant cell formation of Molt-4 cells infected with HIV-1.
Sekine
H
H
Department of Microbiology, Tokyo Metropolitan Research Laboratory of Public Health, Japan.
Ohonuki
N
N
Sadamasu
K
K
Monma
K
K
Kudoh
Y
Y
Nakamura
H
H
Okada
Y
Y
Okuyama
T
T
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D003588:Cytopathogenic Effect, Viral / Q000187:drug effects*; D019084:Fluorescent Antibody Technique, Indirect; D015488:HIV Antigens / Q000096:biosynthesis*; D015497:HIV-1 / Q000187:drug effects* / Q000276:immunology; D006801:Humans; D008970:Molecular Weight; D010936:Plant Extracts / Q000737:chemistry / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000276:immunology / Q000821:virology
D000998:Antiviral Agents; D015488:HIV Antigens; D010936:Plant Extracts