title: [Genetic-demographic study of mountain populations of Daghestan and migrants from it to the lowlands. Study of genetic and marital structure].
abstract: The results of a genetic and demographic study of two "split" isolates of small native ethnic groups of Daghestan are described. Parts of these populations were resettled from habitual highland ecological conditions to radically new lowland conditions in the 1940s. These split isolates were compared with a population of native inhabitants of the Daghestan lowland. It was found that, since resettling, separated populations originating from split isolates became significantly different in both marriage and genetic structures. This is manifested in different phenotypic and allelic frequencies of a number of physiological and biochemical markers and in levels of their heterozygosity. To explain the differences revealed, a hypothesis was proposed about the relationship between levels of inbreeding, heterozygosity, and physiologic sensitivity that account for the differential adaptability of members of the isolated populations to changing environmental conditions. This is the first report of a series of papers describing the experimental testing of this hypothesis. While testing the validity of the hypothesis in this study, a positive linear correlation was found between inbreeding and homozygosity levels.
authors.forename: K B
authors.initials: KB
authors.lastname: Bulaeva
authors.forename: T A
authors.initials: TA
authors.lastname: Pavlova
authors.forename: I E
authors.initials: IE
authors.lastname: Bodia
authors.forename: G G
authors.initials: GG
authors.lastname: Guseĭnov
authors.forename: S M
authors.initials: SM
authors.lastname: Charukhilova
mesh_terms: D003241:Consanguinity; D003710:Demography; D005006:Ethnicity / Q000235:genetics; D005828:Genetics, Population; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D044468:Native Hawaiian or Pacific Islander; D044469:Racial Groups; D012426:Russia; D014171:Transients and Migrants
vernacular_title: Genetiko-demograficheskoe issledovanie gorskikh populiatsiĭ Dagestana i migrantov iz nikh na ravninu. Izuchenie geneticheskoĭ i brachnoĭ struktury.