title: Purification and characterization of a paralytic polypeptide from larvae of Myrmeleon bore.
abstract: A toxic substance was purified from larvae of the antilion, Myrmeleon bore, by DEAE Sephacel and Phenyl Superose column chromatography. The substance was a large polypeptide with a molecular weight of about 165-167 kDa. Its paralytic activity measured by injection against German cockroaches was about 130 times higher than that of tetrodotoxin on a molar basis.
authors.affiliation: Department of Agricultural Chemistry, Kinki University, Nara, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsuda
authors.forename: H
authors.initials: H
authors.lastname: Suzuki
authors.forename: F
authors.initials: F
authors.lastname: Nakanishi
authors.forename: K
authors.initials: K
authors.lastname: Shio
authors.forename: K
authors.initials: K
authors.lastname: Komai
authors.forename: K
authors.initials: K
authors.lastname: Nishimura
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001180:Arthropod Venoms / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D003058:Cockroaches / Q000187:drug effects; D007313:Insecta; D007814:Larva / Q000378:metabolism; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010446:Peptide Fragments / Q000737:chemistry; D010455:Peptides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013779:Tetrodotoxin / Q000494:pharmacology; D014118:Toxins, Biological / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D014688:Venoms / Q000737:chemistry*
chemical_list: D001180:Arthropod Venoms; D010446:Peptide Fragments; D010455:Peptides; D014118:Toxins, Biological; D014688:Venoms; D013779:Tetrodotoxin