title: [Combination therapy of high dose 5'-DFUR+MMC for advanced or recurrent gastric cancer. 5'-DFUR Joint Research Group in the Osaka District for Gastric Cancer].
abstract: We conducted multi-center clinical trials of 'Treatment with high dose 5'-DFUR+MMC' in order to evaluate the effects, the possibility for outpatient treatment and the survival effects in patients with advanced or recurrent gastric cancer. The treatment schedule was as follow; 5'-DFUR 1,600 mg/body/day was given orally for five consecutive days every week and MMC 6 mg/m2 was injected intravenously once every four weeks. Forty-eight patients were enrolled and 34 cases were evaluated for anti-tumor responses. The overall response rate was 29.4% (10/34 cases). Side effects were mainly diarrhea, but outpatient treatment was possible in most cases. The median survival period was 249 days, which is longer than with other treatments. This result suggests that this combination chemotherapy is useful in patients with advanced or recurrent gastric cancers.
authors.affiliation: Dept. of Surgery, Osaka Medical College.
authors.forename: E
authors.initials: E
authors.lastname: Nakata
authors.forename: K
authors.initials: K
authors.lastname: Okajima
authors.forename: Y
authors.initials: Y
authors.lastname: Ishida
authors.forename: Y
authors.initials: Y
authors.lastname: Munetomo
authors.forename: K
authors.initials: K
authors.lastname: Gotoh
authors.forename: M
authors.initials: M
authors.lastname: Toyohara
authors.forename: H
authors.initials: H
authors.lastname: Miyazaki
authors.forename: S
authors.initials: S
authors.lastname: Matsunaga
authors.forename: Y
authors.initials: Y
authors.lastname: Maeura
authors.forename: T
authors.initials: T
authors.lastname: Fujimura
mesh_terms: D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D003967:Diarrhea / Q000139:chemically induced; D004334:Drug Administration Schedule; D005260:Female; D005467:Floxuridine / Q000008:administration & dosage; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D016685:Mitomycin / Q000008:administration & dosage; D009364:Neoplasm Recurrence, Local / Q000188:drug therapy*; D013274:Stomach Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016019:Survival Analysis
chemical_list: D005467:Floxuridine; D016685:Mitomycin; C025034:doxifluridine