title: Progressive late delayed postirradiation encephalopathy with Klüver-Bucy syndrome. Serial MRI and clinico-pathological studies.
abstract: The first pathologically documented case of progressive late delayed postirradiation encephalopathy in a 37-year-old man with Klüver-Bucy syndrome (KBS) is reported here. The pathological findings and clinical course of KBS with recurrent stroke-like episodes and partial epilepsy within a 7-year period following a 'safe dose' radiation therapy for pituitary tumor are presented. Serial magnetic resonance imaging shows, at different stages of the disease, a pontine infarct, enlarged temporal lobes with serpentine hyperintense signal at cortical gyri on T2-weighted and proton density MRI, and progressive brain calcification which appears hyperintense on T1-weighted images and hypointense on T2-weighted images.
authors.affiliation: Section of Neurology, Cathay General Hospital, Taipei, Taiwan.
authors.forename: P
authors.initials: P
authors.lastname: Thajeb
mesh_terms: D000239:Adenoma, Acidophil / Q000532:radiotherapy; D000328:Adult; D001921:Brain / Q000473:pathology / Q000528:radiation effects*; D001925:Brain Damage, Chronic / Q000175:diagnosis* / Q000473:pathology; D002114:Calcinosis / Q000175:diagnosis / Q000473:pathology; D002544:Cerebral Infarction / Q000175:diagnosis / Q000473:pathology; D002561:Cerebrovascular Disorders / Q000175:diagnosis* / Q000473:pathology; D004828:Epilepsies, Partial / Q000175:diagnosis* / Q000473:pathology; D005500:Follow-Up Studies; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010910:Pituitary Irradiation; D010911:Pituitary Neoplasms / Q000532:radiotherapy; D011832:Radiation Injuries / Q000175:diagnosis* / Q000473:pathology; D011879:Radiotherapy Dosage; D012008:Recurrence; D013577:Syndrome