title: Pheochromocytoma and secondary erythrocytosis: role of tumour erythropoietin secretion.
abstract: Certain neoplasias can induce unregulated erythropoietin (EPO) secretion which results in secondary erythrocytosis. Pheochromocytoma associated with erythrocytosis constitute a rare condition, where the secondary red cell abnormality is believed to be due to tumour EPO secretion. In one such case of pheochromocytoma related erythrocytosis, quantitative determination of serum EPO by enzyme immunoassay was combined with immunohistochemical examination of tumour tissue sections to locate the site of EPO secretion. EPO levels were initially high but decreased after tumour surgery, while immunolocalization showed EPO to be secreted by the neoplastic cells.
authors.affiliation: Laboratoire d'Hématologie-Immunologie, CHRU, Rennes, France.
authors.forename: B
authors.initials: B
authors.lastname: Drénou
authors.forename: Y
authors.initials: Y
authors.lastname: Le Tulzo
authors.forename: S
authors.initials: S
authors.lastname: Caulet-Maugendre
authors.forename: A
authors.initials: A
authors.lastname: Le Guerrier
authors.forename: C
authors.initials: C
authors.lastname: Leclercq
authors.forename: I
authors.initials: I
authors.lastname: Guilhem
authors.forename: N
authors.initials: N
authors.lastname: Lecoq
authors.forename: R
authors.initials: R
authors.lastname: Fauchet
authors.forename: R
authors.initials: R
authors.lastname: Thomas
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications / Q000378:metabolism*; D000328:Adult; D006801:Humans; D008297:Male; D010673:Pheochromocytoma / Q000150:complications / Q000378:metabolism*; D011086:Polycythemia / Q000209:etiology*