Inhibitory effects of methanolic extract from corydalis tuber against types I-IV allergic models.
Methanolic extract (CM-ext) from tubers of Corydalis turtschaninovii forma yanhusuo has been screened for activity in experimental models of types I-IV allergy. In type I allergic models, CM-ext at doses of 200, 500 mg/kg, p.o. inhibited 48-h homologous passive cutaneous anaphylaxis (PCA) in rats which is related to IgE, and 4-h heterologous PCA in guinea pigs which is related to IgG. The inhibition of CM-ext on 48-h PCA was also recognized in adrenalectomized rats. CM-ext exhibited the inhibitory effect on formation of IgE antibody in BALB/c mice. In type II allergic model, it was found that CM-ext inhibits reversed cutaneous anaphylaxis (RCA). In type III allergic model, CM-ext showed the inhibitory effect on direct passive arthus reaction (DPAR) in rats. Furthermore, in type IV allergic model, CM-ext had the inhibitory effects on induction phase and effector phase in picryl chloride-induced contact dermatitis (PC-CD). It also showed therapeutic action on PC-CD. These results indicated that CM-ext not only inhibits antibody-mediated allergic reactions but also influences cell-mediated allergic reactions and should be recognized as a potent material for allergic reactions, although the mechanisms and active principles of CM-ext have not yet been completely determined.
Matsuda
H
H
Faculty of Pharmaceutical Sciences, Kinki University, Osaka, Japan.
Tokuoka
K
K
Wu
J
J
Tanaka
T
T
Kubo
M
M
D000818:Animals; D018926:Anti-Allergic Agents / Q000494:pharmacology*; D001183:Arthus Reaction / Q000517:prevention & control; D004205:Cromolyn Sodium / Q000494:pharmacology; D003877:Dermatitis, Contact / Q000517:prevention & control; D004365:Drugs, Chinese Herbal / Q000494:pharmacology; D005260:Female; D006168:Guinea Pigs; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis; D008297:Male; D000432:Methanol; D051379:Mice; D008807:Mice, Inbred BALB C; D008813:Mice, Inbred ICR; D010323:Passive Cutaneous Anaphylaxis / Q000187:drug effects; D018517:Plant Roots / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D011817:Rabbits; D051381:Rats; D017207:Rats, Sprague-Dawley; D017208:Rats, Wistar
D018926:Anti-Allergic Agents; D004365:Drugs, Chinese Herbal; D007073:Immunoglobulin E; D004205:Cromolyn Sodium; D000432:Methanol