title: Long-term follow-up of low-dose methotrexate therapy in one case of idiopathic retroperitoneal fibrosis.
abstract: Idiopathic retroperitoneal fibrosis (RPF) is characterized by the development of a fibrotic mass surrounding the abdominal aorta and its branches, of unknown aetiology. Several immunological mechanisms can be operative in the pathogenesis of RPF. Based on this assumption we treated a patient affected by idiopathic RPF with low-dose methotrexate (MTX) therapy. To our knowledge this is the first example of the effectiveness and safety of a long-term low-dose MTX treatment in the post-surgical management of RPF.
authors.affiliation: Institute of Rheumatology, University La Sapienza, Rome, Italy.
authors.forename: A S
authors.initials: AS
authors.lastname: Scavalli
authors.forename: A
authors.initials: A
authors.lastname: Spadaro
authors.forename: V
authors.initials: V
authors.lastname: Riccieri
authors.forename: G P
authors.initials: GP
authors.lastname: Ricciuti
authors.forename: E
authors.initials: E
authors.lastname: Taccari
authors.forename: M
authors.initials: M
authors.lastname: Marini
authors.forename: A
authors.initials: A
authors.lastname: Zoppini
mesh_terms: D000328:Adult; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D012185:Retroperitoneal Fibrosis / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000601:surgery; D014057:Tomography, X-Ray Computed
chemical_list: D007166:Immunosuppressive Agents; D008727:Methotrexate