Centrally applied bombesin increases nerve activity of both sympathetic and adrenal branch of the splanchnic nerves.
We reported that centrally applied bombesin probably excites both the gastric sympathetic and adrenomedullary systems and thus induces inhibition of gastric acid secretion. In the present study, therefore, we examined whether or not centrally applied bombesin directly affects sympathetic nerve activities in rats anesthetized with urethane. Intracerebroventricular administration of bombesin (0.3 and 3.0 nmol) increased discharge rates of the sympathetic branch as well as those of the adrenal branch of preganglionic greater splanchnic nerves. These effects were not secondary to changes in arterial blood pressure by bombesin. In conclusion, centrally applied bombesin directly activates both the sympathetic and adrenomedullary systems.
Okuma
Y
Y
Department of Pharmacology, Kochi Medical School, Japan.
Yokotani
K
K
Osumi
Y
Y
D000200:Action Potentials / Q000187:drug effects; D000313:Adrenal Medulla / Q000187:drug effects / Q000294:innervation*; D000758:Anesthesia; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D001839:Bombesin / Q000008:administration & dosage / Q000494:pharmacology*; D007276:Injections, Intraventricular; D008297:Male; D009476:Neurons, Efferent / Q000187:drug effects / Q000648:ultrastructure; D009599:Nitroprusside / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013153:Splanchnic Nerves / Q000187:drug effects* / Q000648:ultrastructure; D013564:Sympathetic Nervous System / Q000187:drug effects* / Q000648:ultrastructure; D013566:Sympathomimetics / Q000008:administration & dosage / Q000494:pharmacology*; D014520:Urethane; D014665:Vasodilator Agents / Q000494:pharmacology
D013566:Sympathomimetics; D014665:Vasodilator Agents; D009599:Nitroprusside; D014520:Urethane; D001839:Bombesin