Low dose of ethanol suppresses mismatch negativity of auditory event-related potentials.
The acute effect of a low dose of ethanol (0.5 g/kg) on attention and auditory event-related potentials (ERPs) was investigated in 10 social drinkers using a single-blind, placebo-controlled cross-over design. A dichotic listening task, in which the subjects were instructed to attend selectively to stimuli to one ear while ignoring stimuli to the other, was used. The amplitudes of N1, P2, and the mismatch negativity (MMN) were significantly diminished by alcohol. The latencies of the MMN and N2b were also significantly increased after alcohol ingestion. The novel finding of the significant (> 60% reduction in amplitude) suppression of the MMN can be interpreted as indicating disturbed preconscious detection of acoustic changes outside the scope of attention. Because this is a prerequisite to an attentional shift, the MMN suppression may be related to increased risk for accidents after alcohol ingestion. The same dose of alcohol that suppressed the MMN left intact selective attention and conscious "target" detection, as reflected by the processing negativity and P3 deflections, thus suggesting that the automatic functions of human information processing are more sensitive to alcohol than the controlled, attentional functions.
Jääskeläinen
I P
IP
Department of Psychology, University of Helsinki, Finland.
Lehtokoski
A
A
Alho
K
K
Kujala
T
T
Pekkonen
E
E
Sinclair
J D
JD
Näätänen
R
R
Sillanaukee
P
P
D000328:Adult; D000435:Alcoholic Intoxication / Q000503:physiopathology*; D001288:Attention / Q000187:drug effects* / Q000502:physiology; D002540:Cerebral Cortex / Q000187:drug effects / Q000503:physiopathology; D003265:Contingent Negative Variation / Q000187:drug effects* / Q000502:physiology; D018592:Cross-Over Studies; D004007:Dichotic Listening Tests; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D000431:Ethanol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005072:Evoked Potentials, Auditory / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006801:Humans; D008297:Male; D016037:Single-Blind Method
D000431:Ethanol