Age-related changes of mRNA expression of amyloid precursor protein in the brain of senescence-accelerated mouse.
APP695 mRNA is only expressed in the brains of SAM. The expression of APP mRNA in SAM P1 mice brains is more marked than that in SAM R1 mice brain. APP mRNA expression was increased with advancing age in all brain regions of SAM P1 mice compared with SAM R1. Especially, the changes of the amount of APP mRNA in the prosencephalon and the mesencephalon are significant at P value of 0.05. We suggest that overexpression of APP mRNA may be related to accelerated aging phenomenon in the SAM brain. This is the first report of age-related increase in the amount of APP mRNA in the SAM brain.
Cho
H S
HS
Department of Pharmacology, College of Medicine, Seoul National University, Korea.
Kim
S S
SS
Choi
W
W
Kim
S H
SH
Jeong
S J
SJ
Rhyna-Hong
Chong
Y H
YH
Lee
Y J
YJ
Park
C W
CW
Lee
K W
KW
D000375:Aging; D000818:Animals; D001921:Brain / Q000378:metabolism*; D051379:Mice; D008817:Mice, Mutant Strains; D012333:RNA, Messenger / Q000096:biosynthesis; D000685:Serum Amyloid A Protein / Q000096:biosynthesis*
D012333:RNA, Messenger; D000685:Serum Amyloid A Protein