title: Insulinotropic action of (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate. II. Ionophoretic and conformational aspects.
abstract: 1. The non-sulphonylurea insulinotropic agent sodium (2S)-2-benzyl-3-(cis-hexahydro-2-isoindolinylcarbonyl) propionate (KAD-1229) was found to display calcium ionophoretic activity in an artificial membrane model. 2. Conformation analysis indicated that a complex between calcium and KAD-1229, with a 1:2 stoichiometry, indeed displays favourable attributes for ionophoretic activity across a hydrophobic environment. 3. It is speculated that the ionophoretic property of KAD-1229 might participate to the remodelling of cationic fluxes evoked by this insulinotropic agent in pancreatic islet cells.
authors.affiliation: Laboratoires de Médecine Expérimentale et de Chimie Physique des Macromolécules aux Interfaces, Brussels Free University, Belgium.
authors.forename: W J
authors.initials: WJ
authors.lastname: Malaisse
authors.forename: A B
authors.initials: AB
authors.lastname: Nadi
authors.forename: F
authors.initials: F
authors.lastname: Malaisse-Lagae
authors.forename: F
authors.initials: F
authors.lastname: Sato
authors.forename: L
authors.initials: L
authors.lastname: Lins
authors.forename: R
authors.initials: R
authors.lastname: Brasseur
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism / Q000494:pharmacology; D002412:Cations / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000737:chemistry* / Q000494:pharmacology*; D007211:Indoles / Q000737:chemistry* / Q000494:pharmacology*; D007476:Ionophores; D054833:Isoindoles; D008958:Models, Molecular; D015394:Molecular Structure; D051381:Rats
chemical_list: D002412:Cations; D007004:Hypoglycemic Agents; D007211:Indoles; D007476:Ionophores; D054833:Isoindoles; C087255:mitiglinide; D002118:Calcium