title: A novel gene family encoding proteins with highly differing structure because of a rapidly evolving exon.
abstract: Despite vast differences in primary structure, it is here shown that several predominant semen proteins are encoded by genes that belongs to a common family. Members have their transcription unit split into three exons: the first encoding the signal peptide, the second the secreted protein, while the third exon solely consists of 3' non-translated nucleotides. The first and the third exon are conserved between members, but the second exon is not. The genes for human semenogelins I and II, rat SVSII, SVSIV, SVSV and guinea pig GP1 and GP2 belong to this gene family.
authors.affiliation: Department of Clinical Chemistry, Lund University, Malmö University Hospital, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Lundwall
authors.forename: C
authors.initials: C
authors.lastname: Lazure
mesh_terms: D000818:Animals; D001483:Base Sequence; D017124:Conserved Sequence; D004247:DNA; D019143:Evolution, Molecular; D005091:Exons; D012739:Gonadal Steroid Hormones / Q000235:genetics; D006168:Guinea Pigs; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D005810:Multigene Family; D029584:Prostatic Secretory Proteins; D011506:Proteins / Q000235:genetics*; D051381:Rats; D012661:Semen; D029589:Seminal Plasma Proteins; D029607:Seminal Vesicle Secretory Proteins; D012689:Sequence Homology, Nucleic Acid
chemical_list: D012739:Gonadal Steroid Hormones; D029584:Prostatic Secretory Proteins; D011506:Proteins; D029589:Seminal Plasma Proteins; D029607:Seminal Vesicle Secretory Proteins; C043076:beta-microseminoprotein; C424482:seminal vesicle-specific antigen; D004247:DNA