title: Lentivirus infection in an African lion: a clinical, pathologic and virologic study.
abstract: In May 1991, clinical, pathologic, and virologic investigations were carried out on an 8-yr-old male lion (Panthera leo), with recurrent infections, in captivity with two lionesses in the Zoological Garden of Pistoia, Tuscany, Italy. The lion had severe pneumonia, neutropenia, thrombocytopenia, and an increase in blood urea nitrogen and creatininemia; in spite of therapy, it died within 3 months. At necropsy, the animal had a lymphoma and other lesions similar to those described in feline immunodeficiency virus-infected cats. We identified FIV gag-sequence using PCR amplification of lymph node tissues.
authors.affiliation: Department of Animal Pathology, University of Pisa, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Poli
authors.forename: F
authors.initials: F
authors.lastname: Abramo
authors.forename: P
authors.initials: P
authors.lastname: Cavicchio
authors.forename: P
authors.initials: P
authors.lastname: Bandecchi
authors.forename: E
authors.initials: E
authors.lastname: Ghelardi
authors.forename: M
authors.initials: M
authors.lastname: Pistello
mesh_terms: D000818:Animals; D000836:Animals, Zoo; D000914:Antibodies, Viral / Q000097:blood; D000956:Antigens, Viral / Q000276:immunology; D001806:Blood Urea Nitrogen; D015139:Blotting, Southern / Q000662:veterinary; D015153:Blotting, Western / Q000662:veterinary; D016765:Coronavirus, Feline / Q000276:immunology; D003404:Creatinine / Q000097:blood; D004279:DNA, Viral / Q000032:analysis; D016181:Feline Acquired Immunodeficiency Syndrome / Q000150:complications / Q000821:virology; D015683:Gene Products, gag / Q000235:genetics; D016089:Immunodeficiency Virus, Feline / Q000235:genetics / Q000276:immunology*; D016180:Lentivirus Infections / Q000150:complications / Q000662:veterinary* / Q000821:virology; D005256:Leukemia Virus, Feline / Q000276:immunology; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000209:etiology / Q000662:veterinary; D008045:Lions; D008198:Lymph Nodes / Q000473:pathology / Q000821:virology; D008297:Male; D009503:Neutropenia / Q000209:etiology / Q000662:veterinary; D011018:Pneumonia, Pneumococcal / Q000209:etiology / Q000662:veterinary; D016133:Polymerase Chain Reaction / Q000662:veterinary; D013921:Thrombocytopenia / Q000209:etiology / Q000662:veterinary
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D004279:DNA, Viral; D015683:Gene Products, gag; C074662:p24 protein, Feline immunodeficiency virus; D003404:Creatinine