Treatment of arthritis in Lewis rats by a monoclonal antibody against alpha beta T cell receptor: differential sensitivity of Yersinia-induced arthritis versus adjuvant arthritis.
Lewis rats experimentally infected with Yersinia enterocolitica develop sterile arthritis similar to Yersinia-associated reactive arthritis in humans. To investigate the putative role of alpha beta T cells in the pathogenesis of Yersinia-induced arthritis (YIA) rats were treated with the monoclonal antibody (mAb) R73 mAb directed against the rat alpha beta T cell receptor. In spite of reduction of alpha beta T cells in peripheral blood and in liver lesions of Yersinia-infected rats this serotherapy had no suppressive effect on YIA. Moreover, R73 mAb treatment had no influence on the number of alpha beta T cells in the inflammed synovial tissue. In contrast, R73 mAb serotherapy in Mycobaterium tuberculosis-immunized rats blocked development of adjuvant arthritis (AA) and suppressed the presence of alpha beta T cells in the synovial tissue. These results suggest fundamental differences between the immunopatho-mechanism of YIA caused by bacterial infection and AA induced by bacterial immunization and known to be T cell mediated. These data might have consequences for putative serotherapy of arthritis in humans.
Gaede
K
K
Institut für Hygiene und Mikrobiologie, Universität Würzburg, Germany.
Nazet
M
M
Bosse
D
D
Hünig
Heesemann
J
J
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology / Q000627:therapeutic use*; D001169:Arthritis, Experimental / Q000628:therapy*; D001170:Arthritis, Infectious / Q000209:etiology / Q000628:therapy*; D008099:Liver / Q000473:pathology; D008297:Male; D051381:Rats; D011917:Rats, Inbred Lew; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000276:immunology*; D013047:Specific Pathogen-Free Organisms; D013154:Spleen / Q000473:pathology; D013583:Synovial Membrane / Q000473:pathology; D013601:T-Lymphocytes / Q000276:immunology; D013643:Tarsus, Animal / Q000473:pathology; D015009:Yersinia Infections / Q000209:etiology / Q000628:therapy*; D015008:Yersinia enterocolitica / Q000472:pathogenicity*
D000911:Antibodies, Monoclonal; D016693:Receptors, Antigen, T-Cell, alpha-beta