title: Flip and Flop variants of AMPA receptors in the rat lumbar spinal cord.
abstract: The expression of eight messenger RNA splice forms encoding the Flip and Flop variants of AMPA receptor subunits GluR-A to -D in the rat lumbar spinal cord was examined by in situ hybridization using specific oligonucleotides. In the dorsal horn (laminae I, II and III) the predominant mRNA was GluR-B Flip. Much lower levels of GluR-A Flip were found in lamina I and in superficial parts of lamina II outer. In the ventral horn, motor neurons expressed mainly GluR-B Flip, GluR-C Flip and Flop, and GluR-D Flip. Serial sectioning through large motor neurons indicated that a given cell contained, for example, both GluR-C Flip and Flop splice types.
authors.affiliation: Max Planck Institute of Psychiatry, Clinical Institute, Munich, Germany.
authors.forename: T R
authors.initials: TR
authors.lastname: Tölle
authors.forename: A
authors.initials: A
authors.lastname: Berthele
authors.forename: W
authors.initials: W
authors.lastname: Zieglgänsberger
authors.forename: P H
authors.initials: PH
authors.lastname: Seeburg
authors.forename: W
authors.initials: W
authors.lastname: Wisden
mesh_terms: D000818:Animals; D005260:Female; D014644:Genetic Variation; D017403:In Situ Hybridization; D008161:Lumbosacral Region; D009046:Motor Neurons / Q000378:metabolism; D012326:RNA Splicing; D051381:Rats; D018091:Receptors, AMPA / Q000235:genetics* / Q000378:metabolism*; D013116:Spinal Cord / Q000378:metabolism*
chemical_list: D018091:Receptors, AMPA