title: Poisoning with anti-hypertensive drugs: alpha-adrenoceptor antagonists.
abstract: Experience with overdosage and toxicity with the alpha (alpha)-adrenoceptor antagonists remains very limited, and all the cases in the literature relate to prazosin overdosage. The selective alpha-blocker appears, however, to have a low acute toxicity. Supportive therapy by the reduction of gastrointestinal absorption, monitoring of vital signs and the correction of hypotension (with intravenous fluids) is indicated.
authors.affiliation: West Midlands Centre for Adverse Drug Reaction Reporting, City Hospital, Birmingham, UK.
authors.forename: G Y
authors.initials: GY
authors.lastname: Lip
authors.forename: R E
authors.initials: RE
authors.lastname: Ferner
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000506:poisoning*; D000959:Antihypertensive Agents / Q000506:poisoning*; D002319:Cardiovascular System / Q000187:drug effects; D062787:Drug Overdose / Q000628:therapy; D006801:Humans; D001523:Mental Disorders / Q000139:chemically induced; D009420:Nervous System / Q000187:drug effects
chemical_list: D000317:Adrenergic alpha-Antagonists; D000959:Antihypertensive Agents