title: Correlation of Tc-99m GSA hepatic studies with biopsies in patients with chronic active hepatitis.
abstract: To determine whether scintigraphic findings of Tc-99m DTPA-galactosyl-HSA (GSA) correspond to histopathologic findings, Tc-99m GSA hepatic scintigraphy and biopsy were compared in 65 patients with chronic active hepatitis. After injecting 185 MBq of Tc-99m GSA, anterior images were obtained at 5 minutes and 15 minutes. Scintigrams were classified into three grades according to the extent of visualization of the cardiac blood pool on 5 minute and 15 minute images. Biopsies were subjectively graded for findings of necrosis and fibrosis. Scintigraphic grades on 5 minute images were correlated with hepatic necrosis and fibrosis and those on 15-minute images with hepatic fibrosis. Scintigraphic abnormalities of Tc-99m GSA correlated well with histopathologic abnormalities, especially with hepatic fibrosis and necrosis in patients with chronic active hepatitis.
authors.affiliation: Department of Radiology, Kumamto University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Tomiguchi
authors.forename: T
authors.initials: T
authors.lastname: Kira
authors.forename: Y
authors.initials: Y
authors.lastname: Oyama
authors.forename: M
authors.initials: M
authors.lastname: Nabeshima
authors.forename: R
authors.initials: R
authors.lastname: Nakashima
authors.forename: A
authors.initials: A
authors.lastname: Tsuji
authors.forename: A
authors.initials: A
authors.lastname: Kojima
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
authors.forename: S
authors.initials: S
authors.lastname: Yoshimatsu
authors.forename: K
authors.initials: K
authors.lastname: Sagara
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D002908:Chronic Disease; D005260:Female; D006505:Hepatitis / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate
chemical_list: D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D016284:Technetium Tc 99m Pentetate