Glyoxalase activities in tumor and non-tumor human urogenital tissues.
Glyoxalase I and glyoxalase II activities have been measured in human tumor and non-tumor samples of 15 kidneys, 15 bladders, 4 testes, 2 adrenals as well as in 4 samples of prostatic adenomas. In all tissues examined glyoxalase I and glyoxalase II activity values varied widely from one patient to another. No significant difference in glyoxalase I activity between the tumor and non-tumor samples was found. When comparison was made between normal and neoplastic tissues of the same patients, glyoxalase I activity was found to be lower in tumor tissues of 10 out of 15 kidneys, and 2 out of 8 bladders and 1 out of 3 testes. A significant (P < 0.004) decrease of glyoxalase II activity was found only in tumor kidney. The possibility of using the present data to predict the relative sensitivity of human tumor tissues to glyoxalase-related chemotherapy is discussed.
Di Ilio
C
C
Instituto di Scienze Biochimiche, Facoltà di Medicina, Università G. D'Annunzio, Chieti, Italy.
Angelucci
S
S
Pennelli
A
A
Zezza
A
A
Tenaglia
R
R
Sacchetta
P
P
D000236:Adenoma / Q000201:enzymology* / Q000473:pathology; D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000201:enzymology / Q000473:pathology; D002292:Carcinoma, Renal Cell / Q000201:enzymology / Q000473:pathology; D002295:Carcinoma, Transitional Cell / Q000201:enzymology / Q000473:pathology; D005260:Female; D006801:Humans; D007668:Kidney / Q000201:enzymology; D007680:Kidney Neoplasms / Q000201:enzymology / Q000473:pathology; D007791:Lactoylglutathione Lyase / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000201:enzymology* / Q000473:pathology; D012016:Reference Values; D018239:Seminoma / Q000201:enzymology / Q000473:pathology; D013736:Testicular Neoplasms / Q000201:enzymology* / Q000473:pathology; D013737:Testis / Q000201:enzymology; D013869:Thiolester Hydrolases / Q000378:metabolism*; D001743:Urinary Bladder / Q000201:enzymology; D001749:Urinary Bladder Neoplasms / Q000201:enzymology / Q000473:pathology; D014551:Urinary Tract / Q000201:enzymology*; D014571:Urologic Neoplasms / Q000201:enzymology* / Q000473:pathology; D000099301:Hydroxyacylglutathione Hydrolase
D007791:Lactoylglutathione Lyase; D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase