title: Gonadoblastoma with coexistent features of mixed germ cell-sex cord stroma tumor: a case report.
abstract: Gonadoblastoma and mixed germ cell-sex cord stroma tumor have been widely recognized as two separate entities on the basis of both clinical and pathological features. The typical morphological pattern of both tumor types was found by us to coexist in the same gonadal tumor in a 14-year-old 46,XY phenotypically female subject who also had a contralateral dysgerminoma. A subserous implant showing the mixed germ cell-sex cord pattern of the primary tumor was detected in the uterine body. Following therapy the patient is alive and well after a 7-year follow-up. The distinction between gonadoblastoma and mixed germ cell-sex cord stroma tumor requires discussion.
authors.affiliation: Istituto di Anatomia e Istologia Patologica, Università degli Studi di Firenze, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Colafranceschi
authors.forename: D
authors.initials: D
authors.lastname: Massi
mesh_terms: D000293:Adolescent; D004407:Dysgerminoma / Q000473:pathology*; D005260:Female; D018238:Gonadoblastoma / Q000473:pathology*; D006801:Humans; D010051:Ovarian Neoplasms / Q000473:pathology*; D010641:Phenotype; D018312:Sex Cord-Gonadal Stromal Tumors / Q000473:pathology*