Developmental toxicity of dinitroaniline herbicides in rats and rabbits. I. Trifluralin.
The potential developmental toxicity of trifluralin was evaluated in rats and rabbits. Pregnant rats and rabbits were dosed once daily by gavage on Gestation Days 6-15 and 6-18, respectively. Doses for rats were 0, 100, 225, 475, or 1000 mg/kg; doses for rabbits were 0, 100, 225, or 500 mg/kg. Cesarean sections were performed on rats and rabbits on Gestation Days 20 and 28, respectively. In rats, maternal toxicity was indicated in the 475 and 1000 mg/kg treatment groups by depression of body weights and food consumption. Fetal viability and morphology were not adversely affected at any dose level. Developmental toxicity was indicated at the 1000-mg/kg dose level by depression of fetal weight. The NOAEL for maternal toxicity in the rat was 225 mg/kg; the NOAEL for developmental toxicity in the rat was 475 mg/kg. In rabbits, maternal toxicity was indicated at the 225 and 500 mg/kg dose levels by abortions and/or deaths in conjunction with anorexia and cachexia. Developmental toxicity was indicated at the 500 mg/kg dose level by depressed fetal viability and weight. Fetal morphology was not adversely affected at any dose level. The NOAELs for maternal and developmental toxicity in the rabbit were 100 and 225 mg/kg, respectively. Based on these data, trifluralin did not exhibit selective toxicity toward the developing conceptus.
Byrd
R A
RA
Toxicology Research Laboratories, Lilly Research Laboratories, Greenfield, Indiana 46140, USA.
Markham
J K
JK
Emmerson
J L
JL
D000814:Aniline Compounds / Q000633:toxicity; D000818:Animals; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D006540:Herbicides / Q000633:toxicity*; D008297:Male; D009574:Nitro Compounds / Q000633:toxicity; D011247:Pregnancy; D011248:Pregnancy Complications / Q000139:chemically induced; D011817:Rabbits; D051381:Rats; D014274:Trifluralin / Q000633:toxicity*
D000814:Aniline Compounds; D006540:Herbicides; D009574:Nitro Compounds; D014274:Trifluralin