Tyrosine kinase inhibitors regulate serotonin uptake in platelets.
Uptake of tritiated serotonin into human platelets was found to be rapidly inhibited by the tyrosine kinase inhibitors, genistein and methyl 2,5-dihydroxycinnamate. Binding studies indicated that uptake inhibition did not correlate with direct binding of these inhibitors to the transporter. Chelation of mobilizable intracellular Ca2+ did not inhibit the effects of genistein on uptake. These results suggest a more direct, non-Ca2+ mediated effect of tyrosine kinase inhibitors on uptake.
Helmeste
D M
DM
Department of Psychiatry, University of California, UCI Medical Center, Orange 92668, USA.
Tang
S W
SW
D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism*; D004533:Egtazic Acid / Q000031:analogs & derivatives / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D019833:Genistein; D006801:Humans; D006873:Hydroquinones / Q000494:pharmacology; D066298:In Vitro Techniques; D007529:Isoflavones / Q000494:pharmacology; D011505:Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D012701:Serotonin / Q000097:blood*
D004791:Enzyme Inhibitors; D006873:Hydroquinones; D007529:Isoflavones; D012701:Serotonin; D004533:Egtazic Acid; D019833:Genistein; D011505:Protein-Tyrosine Kinases; C025603:1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; C048212:erbstatin