title: Calcium channel blockade (isradipine) in treatment of hypertension in pregnancy: a randomized placebo-controlled study.
abstract: OBJECTIVE
  Our purpose was to study the effects of isradipine, a dihydropyridine calcium channel blocker, on mother and fetus in the treatment of hypertensive disorders of pregnancy.
  
  
  METHODS
  The investigation was performed as a two-group, parallel, double-blind multicenter study of isradipine versus placebo. Fifty-four women were randomized to treatment with isradipine slow-release capsules given orally 5 mg twice a day and 57 to a placebo group.
  
  
  RESULTS
  Isradipine lowered the maternal mean arterial blood pressure effectively in women with nonproteinuric hypertension but did not do so in women with proteinuria at recruitment or appearing during treatment. Blood flow in the umbilical artery and maternal renal and liver function were not influenced by treatment. Isradipine had few side effects and was well tolerated.
  
  
  CONCLUSIONS
  Calcium channel blockade with isradipine is effective for treatment of nonproteinuric hypertension but not in preeclampsia.
authors.affiliation: Department of Obstetrics and Gynecology, University Hospital, Lund, Sweden.
authors.forename: D H
authors.initials: DH
authors.lastname: Wide-Swensson
authors.forename: I
authors.initials: I
authors.lastname: Ingemarsson
authors.forename: N O
authors.initials: NO
authors.lastname: Lunell
authors.forename: A
authors.initials: A
authors.lastname: Forman
authors.forename: K
authors.initials: K
authors.lastname: Skajaa
authors.forename: B
authors.initials: B
authors.lastname: Lindberg
authors.forename: S
authors.initials: S
authors.lastname: Lindeberg
authors.forename: K
authors.initials: K
authors.lastname: Marsàl
authors.forename: K E
authors.initials: KE
authors.lastname: Andersson
mesh_terms: D000959:Antihypertensive Agents / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D002121:Calcium Channel Blockers / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy*; D007231:Infant, Newborn; D017275:Isradipine / Q000627:therapeutic use*; D010919:Placebos; D011225:Pre-Eclampsia / Q000188:drug therapy; D011247:Pregnancy; D011249:Pregnancy Complications, Cardiovascular / Q000188:drug therapy*; D011256:Pregnancy Outcome; D011507:Proteinuria / Q000150:complications
chemical_list: D000959:Antihypertensive Agents; D002121:Calcium Channel Blockers; D010919:Placebos; D017275:Isradipine