title: Theoretical approaches to designing novel sequences to fit a given fold.
abstract: One of the major goals of molecular biology is to understand how protein chains fold into a unique three-dimensional structure. Given this knowledge, perhaps the most exciting prospect will be the possibility of designing new proteins to perform designated tasks. The eventual pinnacle of protein engineering will be the fully automated design of a protein with novel structure and function. Achievement of this aim lies far in the future, although some early progress has been made recently.
authors.affiliation: Department of Biochemistry and Molecular Biology, University College, London, UK.
authors.forename: D T
authors.initials: DT
authors.lastname: Jones
mesh_terms: D000595:Amino Acid Sequence; D008958:Models, Molecular; D008969:Molecular Sequence Data; D015202:Protein Engineering; D017510:Protein Folding; D011506:Proteins / Q000737:chemistry*
chemical_list: D011506:Proteins