Schwannoma-derived growth factor interacts with the epidermal growth factor receptor.
Schwannoma-derived growth factor (SDGF) is a potent mitogen and neuronal differentiation factor. Because of its relationship to epidermal growth factor (EGF) and the heregulins, it was asked if SDGF interacts with the EGF receptor or HER2/neu. SDGF binds to and causes the phosphorylation on tyrosine of the EGF receptor but not HER2/neu.
Maher
P A
PA
Department of Molecular and Cellular Growth Biology, Whittier Institute for Diabetes and Endocrinology; La Jolla, California, USA.
Schubert
D
D
D016475:3T3 Cells; D066258:Amphiregulin; D000818:Animals; D001667:Binding, Competitive; D002460:Cell Line; D066255:EGF Family of Proteins; D066246:ErbB Receptors / Q000378:metabolism*; D006023:Glycoproteins; D006133:Growth Substances / Q000378:metabolism*; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D016716:PC12 Cells; D010766:Phosphorylation; D051381:Rats; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000378:metabolism*; D014443:Tyrosine / Q000378:metabolism
D066258:Amphiregulin; D066255:EGF Family of Proteins; D066246:ErbB Receptors; D006023:Glycoproteins; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases; D014443:Tyrosine; C587849:Areg protein, mouse; C587850:Areg protein, rat