title: Assignment of the mouse homologue of a human MEN1 candidate gene, phospholipase C-beta 3 (Plcb3), to chromosome region 19B by FISH.
abstract: A recent study using comparative mapping analysis suggests that the proximal segment of mouse chromosome 19 contains the mouse homologs of the human multiple endocrine neoplasia type 1 (MEN1) flanking markers proximal to the locus. We have recently shown that phospholipase C-beta 3 (PLCB3) is a candidate gene for the MEN1 syndrome. In the present investigation we used fluorescence in situ hybridization with a genomic DNA clone for mouse Plcb3, and mapped the locus to chromosome region 19B. This is in agreement with the comparative mapping of the MEN1 flanking markers in mouse.
authors.affiliation: Department of Internal Medicine, University Hospital, Uppsala, Sweden.
authors.forename: A E
authors.initials: AE
authors.lastname: Gobl
authors.forename: B P
authors.initials: BP
authors.lastname: Chowdhary
authors.forename: W
authors.initials: W
authors.lastname: Shu
authors.forename: L
authors.initials: L
authors.lastname: Eriksson
authors.forename: C
authors.initials: C
authors.lastname: Larsson
authors.forename: G
authors.initials: G
authors.lastname: Weber
authors.forename: K
authors.initials: K
authors.lastname: Oberg
authors.forename: B
authors.initials: B
authors.lastname: Skogseid
mesh_terms: D000818:Animals; D002874:Chromosome Mapping; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D007527:Isoenzymes / Q000235:genetics*; D051379:Mice; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics*; D054799:Phospholipase C beta; D010738:Type C Phospholipases / Q000235:genetics*
chemical_list: D007527:Isoenzymes; D010738:Type C Phospholipases; C518039:PLCB3 protein, human; D054799:Phospholipase C beta; C518040:Plcb3 protein, mouse