title: On the role, design, and analysis of disease prevention trials.
abstract: Some differences between prevention and therapeutic trials are reviewed, as are some of David Byar's contributions to the methodology and practice of prevention trials. This leads to a more detailed discussion of three more technical topics pertinent to prevention trials: (i) the role that aggregate data studies may be able to play to complement analytic epidemiologic studies and prevention trials in the identification of disease prevention strategies; (ii) the methods for analysis of correlated response data, as may arise in group randomized trials; and (iii) the importance of emphasizing overall benefits vs. risks in the design and conduct of disease prevention trials.
authors.affiliation: Fred Hutchinson Cancer Research Center, Seattle, Washington 98104, USA.
authors.forename: R L
authors.initials: RL
authors.lastname: Prentice
mesh_terms: D001699:Biometry / Q000266:history; D049673:History, 20th Century; D006801:Humans; D011315:Preventive Medicine / Q000266:history; D016032:Randomized Controlled Trials as Topic / Q000266:history*; D018570:Risk Assessment; D014481:United States