Leukocyte and endothelial adhesion molecules in ischaemia/reperfusion injuries.
Tissue ischaemia and/or reperfusion cause some of the injury seen in several clinical disorders and are responsible for considerable mortality and morbidity in humans. Part of the injury occurring after reperfusion of ischaemic tissue is the result of interactions between leukocytes adhering to vascular endothelium. Blocking the function of the leukocyte adhesion beta 2 integrin complex (CD11/CD18) leads to improved outcome following ischaemia and reperfusion. Functional blockade of either P-selectin or L-selectin prevents leukocyte rolling. Blocking leukocyte adherence at one of several levels may provide improved outcome in a variety of diseases associated with ischaemia and reperfusion.
Winn
R K
RK
Department of Surgery, University of Washington School of Medicine, Harborview Medical Center, Seattle 98104-2499, USA.
Sharar
S R
SR
Vedder
N B
NB
Harlan
J M
JM
D018845:CD11 Antigens / Q000502:physiology*; D002448:Cell Adhesion; D004730:Endothelium, Vascular / Q000378:metabolism / Q000473:pathology; D006801:Humans; D019041:L-Selectin / Q000502:physiology*; D007962:Leukocytes / Q000378:metabolism* / Q000473:pathology; D019007:P-Selectin / Q000502:physiology*; D015427:Reperfusion Injury / Q000378:metabolism* / Q000503:physiopathology
D018845:CD11 Antigens; D019007:P-Selectin; D019041:L-Selectin