Mitochondrial toxicity of antiviral drugs.
Long-term treatment with antiviral nucleoside analogue drugs, such as AZT, can give rise to delayed and at times severe mitochondrial toxicity. Although these toxic effects are manifest in many tissues, a common disease mechanism can explain the diverse clinical events. A better understanding of these disorders will shed light on genetic mitochondrial diseases and lead to the design of safer and more effective antiviral drugs.
Lewis
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Department of Pathology and Laboratory Medicine, University of Cincinnati College of Medicine, Ohio 45267-0529, USA.
Dalakas
M C
MC
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000188:drug therapy; D000818:Animals; D000998:Antiviral Agents / Q000009:adverse effects / Q000737:chemistry / Q000633:toxicity*; D001086:Arabinofuranosyluracil / Q000031:analogs & derivatives / Q000633:toxicity; D004272:DNA, Mitochondrial / Q000187:drug effects; D004259:DNA-Directed DNA Polymerase / Q000187:drug effects; D016049:Didanosine / Q000633:toxicity; D006801:Humans; D008928:Mitochondria / Q000187:drug effects*; D016047:Zalcitabine / Q000633:toxicity; D015215:Zidovudine / Q000633:toxicity
D000998:Antiviral Agents; D004272:DNA, Mitochondrial; D001086:Arabinofuranosyluracil; D015215:Zidovudine; C043457:fialuridine; D016047:Zalcitabine; D004259:DNA-Directed DNA Polymerase; D016049:Didanosine