title: [Multifactor analysis of ciprofloxacin action on the content of various classes of antibodies to EV vaccine fraction 1 and hemagglutinins].
abstract: The action of ciprofloxacin on the content of antibodies of the IgG, IgM and IgA classes in the blood serum of mice immunized by the EV vaccine fraction 1 as well as on the content of hemagglutinins to sheep erythrocytes was studied in a multifactor analysis with the use of a wide variety of the doses and administration times. In the doses corresponding to the average therapeutic ones ciprofloxacin increased the content of the antibody classes and especially that of IgG. When administered prior to the immunization the antibiotic stimulated the production of the hemagglutinins.
authors.forename: A I
authors.initials: AI
authors.lastname: Iordanova
authors.forename: T V
authors.initials: TV
authors.lastname: Smolkina
authors.forename: A V
authors.initials: AV
authors.lastname: Nikitin
mesh_terms: D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000937:Antigen-Antibody Reactions; D000942:Antigens, Bacterial; D001428:Bacterial Vaccines / Q000276:immunology*; D005591:Chemical Fractionation; D002939:Ciprofloxacin / Q000494:pharmacology*; D004912:Erythrocytes / Q000276:immunology; D005163:Factor Analysis, Statistical; D006388:Hemagglutinins / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D012756:Sheep
chemical_list: D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D006388:Hemagglutinins; D002939:Ciprofloxacin
vernacular_title: Mnogofaktornyĭ analiz deĭstviia tsiprofloksatsina na soderzhanie razlichnykh klassov antitel k 1 fraktsii vaktsiny EV i hemaggliutininov.