Neurotransmitters. NMDA receptors: do glia hold the key?
NMDA receptor stimulation requires binding of a 'co-agonist' and the neurotransmitter glutamate at separate sites. Are ligands for the co-agonist site liberated by glia, following activation of glial glutamate receptors?
Cull-Candy
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S
Department of Pharmacology, University College London, UK.
D000818:Animals; D018698:Glutamic Acid / Q000378:metabolism*; D005998:Glycine / Q000502:physiology; D008024:Ligands; D009457:Neuroglia / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D008024:Ligands; D016194:Receptors, N-Methyl-D-Aspartate; D018698:Glutamic Acid; D005680:gamma-Aminobutyric Acid; D005998:Glycine