title: Transfusion-transmitted human parvovirus B19 infection in a thalassemic patient.
abstract: BACKGROUND
  Human parvovirus (HPV) B19 infection has been shown to be transmissible by clotting factor concentrates, most often resulting in asymptomatic seroconversion. So far, no case of B19 transmission due to single-donor transfusion has been documented.
  
  
  METHODS
  A case of transfusion-transmitted HPV B19 infection in a 22-year-old female thalassemia major patient is described. She presented with an aplastic crisis; this was followed 1 week later by transitory heart failure and acute tricuspid incompetence. The echocardiogram revealed a grade III tricuspid regurgitation and a floating vegetation on the atrial face of the tricuspid lateral leaflet. The tricuspid regurgitation and vegetation spontaneously disappeared within 15 days. Blood cultures for bacteria were repeatedly negative. IgM anti-HPV B19 seroconversion was documented in the acute phase. B19 DNA was detected by polymerase chain reaction and remained detectable up to 4 months after diagnosis. High-titer IgM anti-HPV and B19 DNA were also found in serum samples collected at the time of donation from one of the donors of the blood transfused before the onset of clinical symptoms.
  
  
  CONCLUSIONS
  This case documents the transmission of HPV B19 by the transfusion of 1 red cell unit and the occurrence of possible transient cardiac involvement in this infectious complication.
authors.affiliation: Divisione di Ematologia, Centro Trasfusionale e di Immunologia dei Trapianti, Milan, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Zanella
authors.forename: F
authors.initials: F
authors.lastname: Rossi
authors.forename: C
authors.initials: C
authors.lastname: Cesana
authors.forename: A
authors.initials: A
authors.lastname: Foresti
authors.forename: F
authors.initials: F
authors.lastname: Nador
authors.forename: A S
authors.initials: AS
authors.lastname: Binda
authors.forename: G
authors.initials: G
authors.lastname: Lunghi
authors.forename: M D
authors.initials: MD
authors.lastname: Cappellini
authors.forename: M
authors.initials: M
authors.lastname: Furione
authors.forename: G
authors.initials: G
authors.lastname: Sirchia
mesh_terms: D000328:Adult; D005260:Female; D006801:Humans; D010321:Parvoviridae / Q000302:isolation & purification*; D010322:Parvoviridae Infections / Q000635:transmission*; D065227:Transfusion Reaction; D017086:beta-Thalassemia / Q000150:complications* / Q000628:therapy