Quantitative evaluation of Al maltolate-induced neurodegeneration with subsequent Al removal by desferrioxamine treatment.
The intracisternal administration of aluminum maltolate to New Zealand white rabbits produces a reproducible neurofibrillary degeneration which is significantly reversed by desferrioxamine treatment. Quantitative analysis of brain and spinal cord tissue demonstrates that the aluminum deposition is higher close to the injection site than at locations further removed from the point of administration. Most importantly, treatment with desferrioxamine removes most of the aluminum from the brain and spinal cord, even from the sites of highest concentration. The ability to manipulate this system in the formation and degradation of NFD and in removal of aluminum may shed light on mechanisms of NFD formation and have implications for therapeutic advances in the treatment of certain human neurodegenerative diseases.
Huang
Y
Y
Department of Pathology, University of Virginia Health Sciences Center, Charlottesville 22908, USA.
Savory
J
J
Herman
M M
MM
Nicholson
J R
JR
Reyes
M R
MR
Boyd
J C
JC
Wills
M R
MR
D000535:Aluminum / Q000378:metabolism* / Q000633:toxicity*; D000818:Animals; D002614:Chelating Agents / Q000494:pharmacology*; D003676:Deferoxamine / Q000494:pharmacology*; D008297:Male; D009410:Nerve Degeneration / Q000187:drug effects*; D009942:Organometallic Compounds / Q000633:toxicity*; D011753:Pyrones / Q000633:toxicity*; D011817:Rabbits
D002614:Chelating Agents; D009942:Organometallic Compounds; D011753:Pyrones; C067527:aluminum maltolate; D000535:Aluminum; D003676:Deferoxamine