O'Brien's actinic granuloma: response to isotretinoin.
We describe a 75-year-old man demonstrating the florid clinical features of actinic granuloma of O'Brien. This rare disfiguring condition is believed to result from a granulomatous reaction of the dermis to solar-induced elastosis and is poorly responsive to topical steroids. Twelve weeks' treatment with isotretinoin prevented the development of new granulomata and produced almost complete resolution of established lesions.
Ratnavel
R C
RC
Department of Dermatology, Addenbrooke's Hospital, Cambridge, UK.
Grant
J W
JW
Handfield-Jones
S E
SE
Norris
P G
PG
D000368:Aged; D005148:Facial Dermatoses / Q000188:drug therapy*; D006099:Granuloma / Q000188:drug therapy*; D006801:Humans; D015474:Isotretinoin / Q000627:therapeutic use*; D007641:Keratolytic Agents / Q000627:therapeutic use*; D008297:Male; D009333:Neck; D012871:Skin Diseases / Q000188:drug therapy*
D007641:Keratolytic Agents; D015474:Isotretinoin