Activity of ecdysone analogs in enhancing N-acetylglucosamine incorporation into the cultured integument of Chilo suppressalis.
Ecdysone analogs with various side chains at the 17-position of the steroid structure enhanced the incorporation of N-acetylglucosamine as 20-hydroxyecdysone into the cultured integument prepared from Chilo suppressalis. Their activity in terms of the concentration required to give 50% of the maximum response varied with the structure. Piperonyl butoxide, an inhibitor of oxidation metabolism, did not enhance the in vitro effect of the compounds. The order of potency was ponasterone A > 20-hydroxyecdysone > cyasterone > inokosterone > makisterone A >> ecdysone.
Nakagawa
Y
Y
Department of Agricultural Chemistry, Kyoto University, Japan.
Nishimura
K
K
Oikawa
N
N
Kurihara
N
N
Ueno
T
T
D000117:Acetylglucosamine / Q000378:metabolism*; D000818:Animals; D002478:Cells, Cultured; D002686:Chitin / Q000096:biosynthesis; D002776:Cholestanes / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D004330:Drosophila; D004440:Ecdysone / Q000031:analogs & derivatives* / Q000494:pharmacology*; D007301:Insect Hormones / Q000737:chemistry / Q000494:pharmacology*; D007915:Lepidoptera / Q000378:metabolism*; D010882:Piperonyl Butoxide / Q000494:pharmacology; D013329:Structure-Activity Relationship
D002776:Cholestanes; D007301:Insect Hormones; D002686:Chitin; D004440:Ecdysone; D010882:Piperonyl Butoxide; D000117:Acetylglucosamine