title: Treatment of lead toxicity in calves.
abstract: Thiamine hydrochloride alone or in combination with calcium edetate (Ca-EDTA) was used to treat experimentally-induced lead toxicity in calves. In 12 calves lead toxicity was induced by po administration of 5 mg lead acetate/kg/d until the development of overt signs. The calves were divided into 3 groups: untreated control; thiamine-treated; and thiamine+Ca-EDTA-treated. The use of 25 mg thiamine/kg sc twice daily cured 2/4 calves, whereas 4/4 calves recovered with 25 mg thiamine+110 mg Ca-EDTA/kg iv twice daily. Lead concentrations in blood and tissues were significantly lower and histopathologic lesions were less pronounced in the treated calves. Treatment with thiamine+Ca-EDTA was more effective than the use of thiamine alone.
authors.affiliation: Division of Medicine, Indian Veterinary Research Institute, Izatnagar.
authors.forename: S
authors.initials: S
authors.lastname: Dey
authors.forename: D
authors.initials: D
authors.lastname: Swarup
authors.lastname: Kalicharan
authors.forename: B
authors.initials: B
authors.lastname: Singh
mesh_terms: D000284:Administration, Oral; D000704:Analysis of Variance; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced / Q000188:drug therapy*; D002614:Chelating Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D004492:Edetic Acid / Q000008:administration & dosage / Q000627:therapeutic use*; D007279:Injections, Subcutaneous; D007855:Lead Poisoning / Q000188:drug therapy*; D008297:Male; D009942:Organometallic Compounds / Q000008:administration & dosage / Q000097:blood / Q000506:poisoning; D011897:Random Allocation; D013831:Thiamine / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D002614:Chelating Agents; D009942:Organometallic Compounds; D004492:Edetic Acid; C008261:lead acetate; D013831:Thiamine