Repair and recombination. How to make ends meet.
The repair of double-stranded breaks in DNA and the recombination of antibody gene V(D)J segments share a common pathway involving the Ku protein, which binds DNA ends, and its associated protein kinase.
Roth
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Department of Microbiology and Immunology, Baylor College of Medicine, Houston, Texas 77030, USA.
Lindahl
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Gellert
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D000818:Animals; D000906:Antibodies / Q000235:genetics*; D034961:Antigens, Nuclear; D004265:DNA Helicases; D004260:DNA Repair / Q000502:physiology*; D051747:DNA-Activated Protein Kinase; D004268:DNA-Binding Proteins / Q000502:physiology*; D006801:Humans; D000072200:Ku Autoantigen; D008956:Models, Chemical; D009687:Nuclear Proteins / Q000502:physiology*; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D011995:Recombination, Genetic
D000906:Antibodies; D034961:Antigens, Nuclear; D004268:DNA-Binding Proteins; D009687:Nuclear Proteins; D051747:DNA-Activated Protein Kinase; C497263:PRKDC protein, human; D017346:Protein Serine-Threonine Kinases; D004265:DNA Helicases; C106893:XRCC5 protein, human; C000606509:Xrcc6 protein, human; D000072200:Ku Autoantigen