Endocrine aspects of obesity.
A review is presented of the endocrine status in human obesity. The effect of changes in nutrient intake or body weight and the use of weight-reducing drugs on endocrine systems are discussed. There are several endocrine abnormalities found in obese patients. However, these altered endocrine functions seem secondary to the obese state and do not play a role in the pathogenesis of obesity. Some of these abnormalities are, at least partially, responsible for the development of complications related to the obese state. Weight reduction in general is followed by normalization of endocrine functions. The pharmacological agents used in the treatment of obesity do not influence the endocrine systems significantly.
Drent
M L
ML
Department of Endocrinology, Free University Hospital, Amsterdam, Netherlands.
van der Veen
E A
EA
D005768:Gastrointestinal Hormones / Q000378:metabolism; D013006:Growth Hormone / Q000378:metabolism; D006728:Hormones / Q000378:metabolism*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D009765:Obesity / Q000378:metabolism*; D010187:Pancreatic Hormones / Q000378:metabolism; D010913:Pituitary-Adrenal System; D013564:Sympathetic Nervous System / Q000378:metabolism; D013961:Thyroid Gland / Q000378:metabolism
D005768:Gastrointestinal Hormones; D006728:Hormones; D010187:Pancreatic Hormones; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone