Absence of detectable striatal dopamine D4 receptors in drug-treated schizophrenia.
The difference between saturable binding of [3H]emonapride (to D2, D3 and D4 receptors) and [125I]epidepride (to D2 and D3 receptors) was used to determine dopamine D4 receptors in putamen taken post-mortem from antipsychotic-treated schizophrenic subjects and matched controls. Despite an overall increase in D2/D3 receptor density in schizophrenia, reflecting prior antipsychotic drug treatment, striatal D4 receptors were not significantly detectable in either controls or schizophrenic subjects.
Reynolds
G P
GP
Department of Biomedical Science, University of Sheffield, UK.
Mason
S L
SL
D000368:Aged; D001549:Benzamides / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism*; D018492:Dopamine Antagonists / Q000494:pharmacology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011699:Putamen / Q000378:metabolism; D011759:Pyrrolidines / Q000494:pharmacology; D011954:Receptors, Dopamine / Q000378:metabolism*; D012559:Schizophrenia / Q000378:metabolism*
D001549:Benzamides; D018492:Dopamine Antagonists; D011759:Pyrrolidines; D011954:Receptors, Dopamine; C063525:epidepride; C030265:nemonapride