title: [Breast cancer after preventive subcutaneous mastectomy].
abstract: Because of a family history of breast cancer, a 51-year-old patient underwent bilateral subcutaneous mammectomy in 1988. In February 1994 she presented with a nodule in the supramedial quadrant on the left. Needle biopsy suggested galactophoric adenocarcinoma which was confirmed histologically. A 1.5 cm tumour was removed together with a 3 cm reliquat of glandular tissue. Twelve axillary nodes were dissected and were found to be free of neoplastic infiltration. Hormone receptors were positive. Post-operative radiotherapy was performed. The outcome is unchanged at 6 months. Bilateral subcutaneous mammectomy can be proposed as a preventive measure in patients at risk, but as demonstrated by this case, exeresis is usually incomplete. The level of protection actually achieved is thus questionable. Clinicians should be aware of the risk of breast cancer developing after such elective operations since early screening programmes and the development of genetic methods based on the search for BRCA1 and BRCA2 genes will undoubtedly increase the number of patients requesting preventive measures.
authors.affiliation: Institut Curie, Paris.
authors.forename: R J
authors.initials: RJ
authors.lastname: Salmon
authors.forename: J R
authors.initials: JR
authors.lastname: Vilcoq
mesh_terms: D001943:Breast Neoplasms / Q000235:genetics* / Q000517:prevention & control / Q000601:surgery; D005260:Female; D006801:Humans; D015414:Mastectomy, Subcutaneous; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local; D012307:Risk Factors; D013997:Time Factors
vernacular_title: Cancer du sein après mammectomie sous-cutanée préventive.