[An experimental study of the pharmacological activity of opiate receptor ligands on models of adrenaline-induced arrhythmias].
The influence of intracerebroventricular injection of opioid peptides on the incidence and severity of ventricular arrhythmia induced by intravenous administration of epinephrine was studied. It was found that DAGO, a selective mu-agonist, and DADLE, a nonselective delta-agonist, reduce the incidence and severity of cardiac arrhythmia in rats. On the contrary, DSLET, a selective delta-agonist, and Dynorphin A 1-13 (kappa-agonist), potentiates epinephrine-induced arrhythmias. beta-Endorphin do not affect the arrhythmia. The activation of cerebral mu-opioid receptors is shown to prevent the appearance of arrhythmia. On the contrary, the activation of delta- and kappa-receptors induces the appearance of arrhythmia.
Lishmanov
Iu B
IuB
Maslov
L N
LN
Ugdyzhekova
D S
DS
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy*; D016009:Chi-Square Distribution; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004837:Epinephrine; D008024:Ligands; D008297:Male; D018847:Opioid Peptides / Q000627:therapeutic use*; D051381:Rats; D011957:Receptors, Opioid / Q000819:agonists*
D008024:Ligands; D018847:Opioid Peptides; D011957:Receptors, Opioid; D004837:Epinephrine
Eksperimental'noe izuchenie farmakologicheskoĭ aktivnosti ligandov opiatnykh retseptorov na modeli adrenalinovykh aritmiĭ.