Control of gastric acid with high dose H2-receptor antagonists after omeprazole failure: report of two cases.
Successful omeprazole therapy in patients with symptomatic gastroesophageal reflux (GER) refractory to treatment with H2-receptor antagonists has often been reported. In contrast, successful treatment of GER by H2-receptor antagonists in patients resistant to the acid-suppressing effects of omeprazole is rarely reported. We describe two patients who demonstrated therapeutic responses to high dose H2-receptor antagonists after high dose omeprazole failed to suppress gastric acidity and GER.
Leite
L P
LP
Department of Medicine, Graduate Hospital, Philadelphia, Pennsylvania, USA.
Just
R J
RJ
Castell
D O
DO
Lagerström
P O
PO
D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002927:Cimetidine / Q000627:therapeutic use; D004351:Drug Resistance; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000503:physiopathology; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D016567:Nizatidine / Q000627:therapeutic use; D009853:Omeprazole / Q000627:therapeutic use*
D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D002927:Cimetidine; D009853:Omeprazole; D016567:Nizatidine