[Multiple sclerosis and major depression resistant to treatment. Case of a patient with antidepressive therapy-induced mood disorder, associated with manic features].
Patients with multiple sclerosis show higher prevalence of psychiatric disorders compared to general population, that are hardly managed by pharmacotherapy. In the present report a female patient, 44 years old, with diagnosis (according to DSM-IV) of 340 multiple sclerosis, 296.32 major depressive disorder, recurrent, moderate, 292.84 antidepressant-induced mood disorder, with manic features, is described. In this patient depressive symptoms did not respond to a number of drugs, including tricyclic antidepressants, selective serotonine re-uptake inhibitors hand lithium. Moreover, she had hypomanic and manic episodes induced by two different antidepressant, hydroxy-tryptophan and clorimipramine. Until today, only amisulpride (50 mg/die for four months, then 50 mg every two days for two months) has shown a significant effect on depressive symptomatology, moreover, this drug has not induced the occurrence of manic symptoms.
Pariante
C M
CM
Istituto di Clinica Psichiatrica, Università degli Studi di Cagliari.
Orrù
M G
MG
Carpiniello
B
B
Rudas
N
N
D006916:5-Hydroxytryptophan / Q000009:adverse effects; D000328:Adult; D000341:Affective Disorders, Psychotic / Q000139:chemically induced*; D000929:Antidepressive Agents, Tricyclic / Q000009:adverse effects / Q000627:therapeutic use*; D001714:Bipolar Disorder / Q000139:chemically induced / Q000188:drug therapy / Q000523:psychology*; D002997:Clomipramine / Q000009:adverse effects; D003866:Depressive Disorder / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D008094:Lithium / Q000627:therapeutic use; D009103:Multiple Sclerosis / Q000150:complications / Q000523:psychology*; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use
D006916:5-Hydroxytryptophan; D000929:Antidepressive Agents, Tricyclic; D002997:Clomipramine; D008094:Lithium; D017367:Selective Serotonin Reuptake Inhibitors
Sclerosi multipla e depressione maggiore resistente al trattamento. Il caso di una paziente con disturbo dell'umore indotto dalla terapia antidepressiva, con caratteristiche maniacali.