[Epidemiologic, clinical and hematologic profile of K Woolwich hemoglobinopathies in Ivory Coast].
From 1968 to 1992, the hematology laboratory at the University Hospital Center of Abidjan performed 197705 hemoglobin electrophoreses. Isoelectric focusing using the Basset technique allowed identification of hemoglobin K Woolwich. This abnormality of hemoglobin structure (beta 132 (H10) Lys ... Glu) was detected in 130 cases, i.e. 0.065%. It was homozygous in 3 cases, heterozygous in 110 cases, and associated with other hematologic abnormalities in 17 cases. The abnormality was asymptomatic and did not cause any hematological disturbance. Due to autosomal transmission, hemoglobin K Woolwich is a trait of Akan populations (75% of cases) in which it is dominant in the Attie subgroup. Given its ethnic specificity, this abnormality is of anthropological interest.
Tolo
A
A
Service d'Hérmatologie, Centre Hospitalier Universitaire de Yopougon, Abidjan, Côte d'Ivoire.
Toure
H A
HA
Elenga
J P
JP
Allangba
O
O
Sanogo
I
I
Meite
M
M
Sangare
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D001797:Blood Protein Electrophoresis; D002648:Child; D002675:Child, Preschool; D007560:Cote d'Ivoire / Q000453:epidemiology; D005260:Female; D005799:Genes, Dominant; D006580:Genetic Carrier Screening; D006453:Hemoglobinopathies / Q000097:blood / Q000208:ethnology / Q000235:genetics; D006455:Hemoglobins, Abnormal; D006720:Homozygote; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007525:Isoelectric Focusing; D008297:Male; D008875:Middle Aged; D010641:Phenotype; D011159:Population Surveillance
D006455:Hemoglobins, Abnormal; C050153:hemoglobin K Woolwich
Profil épidémiologique, clinique et hématologique de l'hémoglobine K Woolwich en Côte d'Ivoire.