Induction of morphological transformation in BALB/3T3 mouse embryo cells by okadaic acid.
Okadaic acid is produced by several types of dinoflagellates (marine plankton) and has been implicated as a causative agent of diarrhoetic shellfish poisoning. Okadaic acid, a known tumour promoter in vivo, has been shown to promote morphological transformation of carcinogen-initiated BALB/3T3 cells. This study shows that okadaic acid is capable of inducing morphological transformation of BALB/3T3 cells in the absence of an initiator.
Sheu
C W
CW
Genetic Toxicology Branch, Food and Drug Administration, Washington, DC 20204, USA.
Rodriguez
I
I
Dobras
S N
SN
Lee
J K
JK
D016475:3T3 Cells / Q000187:drug effects*; D000818:Animals; D002273:Carcinogens / Q000009:adverse effects*; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced* / Q000473:pathology; D004988:Ethers, Cyclic / Q000009:adverse effects*; D051379:Mice; D008807:Mice, Inbred BALB C; D019319:Okadaic Acid
D002273:Carcinogens; D004988:Ethers, Cyclic; D019319:Okadaic Acid