Murine CD38: an immunoregulatory ectoenzyme.
CD38 is an ectoenzyme that utilizes NAD+ and is expressed by many cells of hematopoietic origin. Antibodies to CD38 potentiate many biological activities on lymphocytes, including induction of murine B-cell proliferation. In this article, Frances Lund and colleagues summarize information concerning the expression, enzymatic activity and signal transduction pathway utilized by murine CD38.
Lund
F
F
DNAX Research Institute, Palo Alto, CA 94304, USA.
Solvason
N
N
Grimaldi
J C
JC
Parkhouse
R M
RM
Howard
M
M
D036541:ADP-ribosyl Cyclase; D051997:ADP-ribosyl Cyclase 1; D000818:Animals; D015703:Antigens, CD; D000943:Antigens, Differentiation / Q000276:immunology*; D001402:B-Lymphocytes / Q000201:enzymology / Q000276:immunology*; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins; D051379:Mice; D009699:N-Glycosyl Hydrolases / Q000276:immunology*; D015398:Signal Transduction
D015703:Antigens, CD; D000943:Antigens, Differentiation; D008562:Membrane Glycoproteins; D009699:N-Glycosyl Hydrolases; D036541:ADP-ribosyl Cyclase; C498155:Cd38 protein, mouse; D051997:ADP-ribosyl Cyclase 1