Differential antiviral activity of derivatized dextrans.
The antiviral activity of water-soluble dextrans derivatized with varying percentages of carboxymethyl, benzylamide, and sulfonate groups was evaluated. Several of the polymers exhibited potent antiviral activity against a variety of enveloped viruses, but not against non-enveloped viruses, and only when present during virus adsorption. The mechanism of activity against retroviruses [i.e. human immunodeficiency virus (HIV)] and herpes viruses (i.e. human cytomegalovirus) could be ascribed to inhibition of virus binding to the cells. An absolute requirement for anti-HSV activity appeared to be a sufficiently high percentage of benzylamide and benzylamide sulfonate groups. This did not, however, apply for human cytomegalovirus, respiratory syncytial virus, and HIV. The sensitivity of the latter viruses appeared to be influenced by factors other than the global chemical composition, which leads us to assume that physical factors such as the distribution and sequence of the substituents on the sugar backbone play an important role in the antiviral activity of the derivatized dextrans.
Neyts
J
J
Rega Institute for Medical Research, Katholieke Universiteit Leuven, Belgium.
Reymen
D
D
Letourneur
D
D
Jozefonvicz
J
J
Schols
D
D
Este
J
J
Andrei
G
G
McKenna
P
P
Witvrouw
M
M
Ikeda
S
S
D000998:Antiviral Agents / Q000138:chemical synthesis*; D002460:Cell Line; D003587:Cytomegalovirus / Q000187:drug effects; D003911:Dextrans / Q000138:chemical synthesis* / Q000737:chemistry / Q000633:toxicity; D006678:HIV / Q000187:drug effects; D012136:Respiratory Syncytial Viruses / Q000187:drug effects; D018139:Simplexvirus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D003911:Dextrans; C014392:carboxymethyl dextran