[In vitro activity of carbapenems (biapenem, imipenem and meropenem) and some other antibiotics against strict anaerobic bacteria].
During 1994, the in vitro antibiotic susceptibility of 306 anaerobic bacteria was performed in 4 hospitals, by the reference agar dilution method. Among the 129 B. fragilis group strains, only two B. fragilis strains were resistant to the three carbapenems and all beta-lactams, even combined with beta-lactamase-inhibitors while metronidazole resistance could not be detected. Evolution in antibiotic resistance rates could be assessed only for piperacillin whose resistance rates increased to 20%. beta-lactamase production was detected respectively for 27% of Prevotella and 17% of Fusobacterium strains. No beta-lactamase activity was seen among Gram positive anaerobes. On the whole anaerobic strains resistance rates were: biapenem, imipenem, meropenem and piperacillin-tazobactam 0.7, amoxicillin-clavulanic acid or metronidazole 2, piperacillin 11.3, amoxicillin 31%, respectively. The three carbapenems demonstrated a good in vitro activity against most anaerobes with few differences between them.
Bland
S
S
Centre Hospitalier, Annecy, France.
Sedallian
A
A
Grollier
G
G
Mory
F
F
Houcke
I
I
Dubreuil
L
L
D001441:Bacteroides fragilis / Q000187:drug effects*; D003013:Clostridium / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005051:Eubacterium / Q000187:drug effects; D005673:Fusobacterium / Q000187:drug effects; D006801:Humans; D015378:Imipenem / Q000494:pharmacology*; D066298:In Vitro Techniques; D000077731:Meropenem; D010462:Peptostreptococcus / Q000187:drug effects; D018720:Prevotella / Q000187:drug effects*; D013845:Thienamycins / Q000494:pharmacology*
D013845:Thienamycins; D015378:Imipenem; D000077731:Meropenem; C065257:biapenem
Activité in vitro des carbapénèmes (biapénème, imipénème et méropénème) et de quelques antibiotiques sur les anaérobies stricts.