title: A comparison of stereology and segmentation techniques for volumetric measurements of lateral ventricles in magnetic resonance imaging.
abstract: Lateral ventricular volumes were measured on magnetic resonance imaging (MRI) scans by independent raters in 18 subjects (11 psychotic patients and 7 healthy control subjects) with two different approaches: a point-counting stereological (PCS) technique and a computerized technique based on segmentation algorithms. The correlation between the two techniques was very high (r = 0.96), and phantom studies showed good validity for both approaches. These findings and the technical simplicity of the PCS technique support its potential use for MRI morphometric measurements.
authors.affiliation: Department of Psychiatry, University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, PA 15213-2593, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Keshavan
authors.forename: S
authors.initials: S
authors.lastname: Anderson
authors.forename: C
authors.initials: C
authors.lastname: Beckwith
authors.forename: K
authors.initials: K
authors.lastname: Nash
authors.forename: J W
authors.initials: JW
authors.lastname: Pettegrew
authors.forename: K R
authors.initials: KR
authors.lastname: Krishnan
mesh_terms: D002552:Cerebral Ventricles / Q000033:anatomy & histology*; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging; D011618:Psychotic Disorders / Q000503:physiopathology