title: Fluid balance and pulmonary functions during and after coronary artery bypass surgery: Ringer's acetate compared with dextran, polygeline, or albumin.
abstract: The effects on fluid balance, pulmonary functions and economics were evaluated in a randomized comparison of one colloid free and three colloid containing fluid regimens, for 48 hours during and after coronary artery bypass (CAB) surgery. A standard regimen for anaesthesia, extracorporeal circulation and monitoring was used. Only Ringer's acetate (RAc) was used as priming solution for extracorporeal circulation. Forty patients were randomized to receive either RAc, polygeline 35 mg.ml-1 (Haemaccel), dextran 70 (Macrodex) 60 mg.ml-1, or albumin 40 mg.ml-1 in saline whenever fluid volume was needed to stabilize haemodynamics. At the end of the operation, fluid retention was significantly lower in patients receiving polygeline and dextran 70, compared with patients receiving RAc. At 48 hours, however, there were no differences in cumulative fluid balance. Patients in the colloid groups postoperatively had a higher serum colloid osmotic pressure (s-COP), but a higher net lung capillary filtration pressure (delta P) only on the second postoperative day than the RAc group. However, this did not adversely affect intrapulmonary venous admixture, arterial oxygen tension, or time on respirator in the RAc group compared with the colloid groups. The most expensive colloid fluid regimen (albumin) cost about 230 US$ more per patient than the RAc fluid regimen. We conclude that Ringer's acetate for volume replacement to stabilize haemodynamics during and after CAB surgery is associated with increased fluid retention only during the intraoperative period, compared with dextran 70 or polygeline, and with a lower serum colloid osmotic pressure and net lung capillary filtration pressure postoperatively, compared with all three colloid groups. This does not affect pulmonary functions adversely.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anaesthesia, Rikshospitalet, Oslo, Norway.
authors.forename: S
authors.initials: S
authors.lastname: Tølløfsrud
authors.forename: J L
authors.initials: JL
authors.lastname: Svennevig
authors.forename: H
authors.initials: H
authors.lastname: Breivik
authors.forename: U
authors.initials: U
authors.lastname: Kongsgaard
authors.forename: M
authors.initials: M
authors.lastname: Ozer
authors.forename: E
authors.initials: E
authors.lastname: Hysing
authors.forename: B
authors.initials: B
authors.lastname: Mohr
authors.forename: E
authors.initials: E
authors.lastname: Seem
authors.forename: O
authors.initials: O
authors.lastname: Geiran
authors.forename: M
authors.initials: M
authors.lastname: Abdelnour
mesh_terms: D000368:Aged; D000418:Albumins / Q000494:pharmacology; D003102:Colloids; D001026:Coronary Artery Bypass; D003911:Dextrans / Q000494:pharmacology; D005260:Female; D005440:Fluid Therapy; D006801:Humans; D007552:Isotonic Solutions / Q000494:pharmacology; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009997:Osmotic Pressure; D011097:Polygeline / Q000494:pharmacology; D011446:Prospective Studies; D014882:Water-Electrolyte Balance
chemical_list: D000418:Albumins; D003102:Colloids; D003911:Dextrans; D007552:Isotonic Solutions; C028570:Ringer's acetate; D011097:Polygeline