Effects of Dalbergia subcymosa Ducke decoction on rats and their offspring during pregnancy.
In order to evaluate Dalbergia subcymosa Ducke stem bark decoction for possible embryo-fetotoxicity effects and disturbance of postnatal development of pups, female rats were treated on days 6-15 of pregnancy with either the decoction (40 mg/rat) or distilled water (0.5 ml/rat), by gastric intubation. Half of the animals were killed on day 20 and the other half was allowed to deliver. Maternal, fetal and newborn studies suggest absence of embryo-fetotoxicity and no disturbance of postnatal development of the pups indicating that the beverage may be safe for human use as an anti-inflammatory.
Peters
V M
VM
Department of Biology, Centro de Biologia da Reproducão, Federal University of Juiz de Fora, Minas Gerais, Brazil.
Guerra
M de O
Mde O
D000367:Age Factors; D000818:Animals; D000831:Animals, Newborn; D001835:Body Weight / Q000187:drug effects; D001938:Brazil; D005260:Female; D010936:Plant Extracts / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects*; D012737:Sex Factors
D010936:Plant Extracts