Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease.
The effect of the apolipoprotein E (APOE) epsilon 4 allele on age of onset was analyzed in two groups of families with early-onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early-onset non-VG families showing evidence of linkage to chromosome 14. The epsilon 4 allele did not have a detectable effect on age of onset in either group. This finding suggests some forms of early-onset familial AD are not modifiable by APOE status, or that AD can be caused by APOE-independent pathways.
Levy-Lahad
E
E
Division of Medical Genetics, University of Washington, Seattle, USA.
Lahad
A
A
Wijsman
E M
EM
Bird
T D
TD
Schellenberg
G D
GD
D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D013997:Time Factors
D001057:Apolipoproteins E