title: Are perforated gastroduodenal ulcers related to Helicobacter pylori infection?
abstract: The prevalence of Helicobacter pylori gastritis in 36 patients with a perforated ulcer undergoing endoscopy prior to or at least 2 months after perforation was 56%, intermediate between that of age and sex matched healthy blood donors (36%) who had measurement of circulating antibodies to Helicobacter pylori and of ulcer patients without perforation matched for age, sex and ulcer location (86%). In the 20 patients with Helicobacter pylori gastritis, 8 had a history of peptic ulcer and 7 of 9 patients with a follow-up of at least 12 months and no preventive treatment had a symptomatic relapse. The group of patients without infection included 6 young patients (< 40) who did not use non steroidal anti-inflammatory drugs and 10 older patients (> 60): 9 used non steroidal anti-inflammatory drugs and seven had a normal gastric mucosa on biopsy. One patient without Helicobacter pylori had a second perforation, the only relapse in this group. We conclude that patients with perforated ulcers are a heterogeneous group with a recurrent ulcer disease mainly in patients with Helicobacter pylori.
authors.affiliation: Department of Gastroenterology, Clinique St-Pierre, Ottignies, Belgium.
authors.forename: J C
authors.initials: JC
authors.lastname: Debongnie
authors.forename: E
authors.initials: E
authors.lastname: Wibin
authors.forename: M
authors.initials: M
authors.lastname: Timmermans
authors.forename: J
authors.initials: J
authors.lastname: Mairesse
authors.forename: X
authors.initials: X
authors.lastname: Dekoninck
mesh_terms: D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use; D005260:Female; D005756:Gastritis / Q000382:microbiology; D016481:Helicobacter Infections / Q000150:complications* / Q000188:drug therapy / Q000382:microbiology; D016480:Helicobacter pylori; D006801:Humans; D008297:Male; D008875:Middle Aged; D010437:Peptic Ulcer / Q000382:microbiology; D010439:Peptic Ulcer Perforation / Q000150:complications*; D012008:Recurrence
chemical_list: D000900:Anti-Bacterial Agents