title: Levels of interleukin 6 and tumor necrosis factor in serum from humans vaccinated with live, attenuated Francisella tularensis.
abstract: The levels of interleukin 6 (IL-6) and tumor necrosis factor alpha in serum did not change significantly during the course of immunization with the live vaccine strain of Francisella tularensis. Higher levels of circulating IL-6 were found in the sera of vaccinees with good antibody responses than in the sera from nonresponders. Preimmunization levels of IL-6 in serum were also higher in responders than in nonresponders.
authors.affiliation: Applied Research Division, United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland 21702, USA.
authors.forename: T
authors.initials: T
authors.lastname: Krakauer
mesh_terms: D000328:Adult; D001428:Bacterial Vaccines / Q000276:immunology*; D005604:Francisella tularensis / Q000276:immunology*; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000032:analysis*; D014613:Vaccines, Attenuated / Q000276:immunology*
chemical_list: D001428:Bacterial Vaccines; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D014613:Vaccines, Attenuated