In vivo effect of prednisolone on release of leukotriene C4 in eosinophils obtained from asthmatic patients.
We investigated the release of leukotriene C4 from eosinophils of asthmatic patients who were treated with or without intravenous prednisolone. The mean level of LTC4 in the supernatant of A23187-stimulated eosinophils obtained from asthmatic patients during an attack was significantly lower with intravenous prednisolone than without prednisolone treatment. Findings suggest that intravenous prednisolone inhibits the release of LTC4 from the eosinophils of asthmatic patients by acting on these cells in vivo.
Shindo
K
K
First Department of Internal Medicine, Yokohama City University School of Medicine, Japan.
Hirai
Y
Y
Koide
K
K
Sumitomo
M
M
Fukumura
M
M
D000328:Adult; D000368:Aged; D018927:Anti-Asthmatic Agents / Q000494:pharmacology*; D001249:Asthma / Q000097:blood*; D002469:Cell Separation / Q000379:methods; D002499:Centrifugation, Density Gradient; D004804:Eosinophils / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D006801:Humans; D066298:In Vitro Techniques; D017997:Leukotriene C4 / Q000037:antagonists & inhibitors* / Q000097:blood*; D008875:Middle Aged; D011239:Prednisolone / Q000494:pharmacology*; D011863:Radioimmunoassay; D012016:Reference Values
D018927:Anti-Asthmatic Agents; D017997:Leukotriene C4; D011239:Prednisolone