Search for a gene predisposing to manic-depression on chromosome 21.
Six kindreds containing multiple cases of Manic-depressive illness (MDI) were genotyped with seven highly polymorphic microsatellite loci used in the construction of an index map for chromosome 21. The kindreds were also genotyped with a microsatellite polymorphism for PFKL, a chromosome 21 locus that has shown suggestive linkage to MDI in one pedigree [Straub et al., 1993: The American Society of Human Genetics]. Evidence of linkage was not found assuming either autosomal dominant or recessive inheritance. The nonparametric affected sib pair test did not yield significant evidence of linkage.
Byerley
W
W
Department of Psychiatry, University of Utah Medical Center, Salt Lake City 84132, USA.
Holik
J
J
Hoff
M
M
Coon
H
H
D015415:Biomarkers; D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D005190:Family; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male
D015415:Biomarkers