Tissue-specific regulation of the expression of rat intestinal bile acid-binding protein.
A lipid-binding protein identical to the rat intestinal bile acid-binding protein, termed I-15P, was expressed in steroid hormone-producing tissues such as ovary and adrenal gland, but not testis. In immature rats, I-15P was expressed in intestine but not in ovaries. The expression of I-15P in the ovaries of immature rats was induced to the level in immature rats by gonadotropin treatment. This suggests that the expression of I-15P in the ovaries is controlled by the ovarian cycle. The present results indicate that the expression of I-15P is developmentally and hormonally controlled in a tissue-specific manner.
Sato
E
E
Department of Biochemistry, Niigata University School of Medicine, Japan.
Fujii
H
H
Fujita
M
M
Kanda
T
T
Iseki
S
S
Hatakeyama
K
K
Tanaka
T
T
Ono
T
T
D000311:Adrenal Glands / Q000378:metabolism; D000818:Animals; D002352:Carrier Proteins / Q000096:biosynthesis* / Q000235:genetics; D050556:Fatty Acid-Binding Proteins; D005260:Female; D005768:Gastrointestinal Hormones; D005786:Gene Expression Regulation; D006062:Gonadotropins / Q000494:pharmacology; D006913:Hydroxysteroid Dehydrogenases; D007413:Intestinal Mucosa / Q000378:metabolism; D008297:Male; D008562:Membrane Glycoproteins; D010053:Ovary / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013737:Testis / Q000378:metabolism; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)
D002352:Carrier Proteins; D050556:Fatty Acid-Binding Proteins; D005768:Gastrointestinal Hormones; D006062:Gonadotropins; D006913:Hydroxysteroid Dehydrogenases; D008562:Membrane Glycoproteins; C037643:bile acid binding proteins; C057275:fatty acid-binding protein 6; C435496:AKR1C2 protein, human; D045002:3-alpha-Hydroxysteroid Dehydrogenase (B-Specific)