[Inhibitory effect of interleukin-1 beta on insulin release from isolated rat pancreatic islets and the reversal action of testosterone].
Insulin release from pancreatic islet cells of neonatal rats could be markedly inhibited by a previous incubation of cells with interleukin-1 beta (5-20 U/ml) for 20 h even under high glucose (20 mmol/L) stimulation. This inhibitory effect of IL-1 beta on insulin release could be reversed by testosterone (10(-10) mol/L), which was accompanied by an increase of the insulin content in islet cells.
Fang
H L
HL
Department of Physiology, Beijing Medical University.
Wang
L
L
Yang
Y K
YK
Zhu
W Y
WY
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007375:Interleukin-1 / Q000494:pharmacology*; D053583:Interleukin-1beta; D007515:Islets of Langerhans / Q000166:cytology / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000494:pharmacology*
D007328:Insulin; D007375:Interleukin-1; D053583:Interleukin-1beta; D010446:Peptide Fragments; C052994:interleukin-1beta (163-171); D013739:Testosterone