[The function of the kallikrein-kinin system of the blood serum in epilepsy patients during therapy].
Pronounced activation of serum kallikrein-kinin system (KKS) was discovered in epileptic patients. Marked therapeutic effect in 17 patients after 1 month of combined therapy (antioxidants and vitamins) was accompanied by a distinct tendency to normalization of kallikrein and prekallikrein activity and the quantity of immune complexes (IC). Therapy of such patients may consist of one course of treatment followed by supportive vitamin therapy. The increase of previously low kallikrein activity was noticed in 23 patients after the treatment and was connected with the increment of prekallikrein level in the presence of KKS activating factors, including IC. IC quantity increased in comparison to pre-treatment values. This promoted continuation of the treatment till normalization of KKS components and IC. Absence of clinical improvement combined with deterioration of biochemical parameters (in 11 patients) urges the necessity to search for more effective therapeutic measures. Determination of kallikrein, its precursors and IC allows to evaluate efficacy and duration of pathogenetic treatment of epileptic patients.
Kovalenko
V S
VS
Vilkov
G A
GA
Trapezontseva
R A
RA
Mezhova
L I
LI
D000293:Adolescent; D000328:Adult; D000927:Anticonvulsants / Q000627:therapeutic use*; D000936:Antigen-Antibody Complex / Q000097:blood / Q000187:drug effects; D002908:Chronic Disease; D004359:Drug Therapy, Combination; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D016234:Kallikrein-Kinin System / Q000187:drug effects*; D008297:Male; D014815:Vitamins / Q000627:therapeutic use
D000927:Anticonvulsants; D000936:Antigen-Antibody Complex; D014815:Vitamins
Sostoianie kallikrein-kininovoĭ sistemy syvorotki krovi u bol'nykh épilepsieĭ v protsesse terapii.