Hybrid resistance: 'negative' and 'positive' signaling of murine natural killer cells.
Murine NK cells can reject allogenic or parental-strain bone marrow cells (BMC) in vivo and can lyse T lymphoblasts in vitro. The 'missing self' hypothesis states that absence or presence of 'negative signals' from target cell class I antigens (Ag) to NK receptors determines whether or not lysis occurs. Indeed, lysis of parental-strain blasts by purified F1 NK cell subsets occurred only in the presence of anti-receptor antibodies. Evidence for 'positive signaling' to NK cells by class I Ag includes rejection of D8 (Dd) transgene to B6) BMC by B6 hosts. The outcome of other BMC transplants contradict the missing self idea, because donors with identical class I Ag differ in compatibility with certain hosts. Perhaps class I Ag-NK cell receptor interactions dominate over other target-NK cell interactions. These interactions are usually 'negative' but can be 'positive'.
Bennett
M
M
Department of Pathology, University of Texas Southwestern Medical Center at Dallas, USA.
Yu
Y Y
YY
Stoneman
E
E
Rembecki
R M
RM
Mathew
P A
PA
Lindahl
K F
KF
Kumar
V
V
D000818:Animals; D016026:Bone Marrow Transplantation; D003433:Crosses, Genetic; D006084:Graft Rejection / Q000235:genetics*; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D015398:Signal Transduction / Q000276:immunology*