title: Interleukin-2 receptor positive T and B cells in children with acute severe asthmatic attack.
abstract: Subpopulations of interleukin-2 receptor (IL-2R)-positive CD4 and CD8 T cells and IL-2R+CD20 B cells in the peripheral blood lymphocytes as well as serum concentrations of soluble IL-2R (sIL2R) were measured in children aged 1-7 years who suffered acute severe asthmatic attack. Subpopulations of CD4+IL-2R+ cells, CD8+IL-2R+ cells and CD20+IL-2R+ cells in the peripheral blood lymphocytes at acute severe asthmatic attack phase were significantly higher than those at non-asthmatic attack phase (P < 0.02, P < 0.03 and P < 0.02, respectively). Subpopulations of CD20+IL-2R+ cells in the peripheral blood lymphocytes significantly decreased 5-10 days after acute severe asthmatic attack (at recovery phase, P < 0.02) and were significantly correlated with clinical severity of asthmatic attack (P < 0.05). These results indicated that activation of both T cells and B cells was important in the pathogenesis of acute asthmatic attack in young children.
authors.affiliation: Department of Pediatrics, Kure Mutual Aid Hospital, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Nabetani
authors.forename: T
authors.initials: T
authors.lastname: Yamasaki
authors.forename: A
authors.initials: A
authors.lastname: Kameda
authors.forename: O
authors.initials: O
authors.lastname: Okamoto
authors.forename: T
authors.initials: T
authors.lastname: Kishimoto
mesh_terms: D001249:Asthma / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008213:Lymphocyte Activation; D008297:Male; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D015375:Receptors, Interleukin-2