[Changes in CT-scan findings of liver metastases from gastric carcinoma treated by hepatic arterial infusion chemotherapy, especially after chemo-embolization and induced hypertensive chemotherapy].
The purpose of this study was to clarify the effectiveness of hepatic arterial infusion chemotherapy (HAIC) from not only the reduction rate but also the characteristic findings in CT-scan. Subjects were nine responders of HAIC for liver metastases from gastric carcinoma (chemo-embolization, 4 cases; induced hypertensive chemotherapy, 5 cases). Low density (LD), enhancement and indentation of the metastatic lesions were the characteristic findings. As the result, LD was more frequent in chemo-embolization cases (100%) than in induced hypertensive chemotherapy cases (60%). LD change, which was appeared in four cases before partial response, was one of the findings indicating the effectiveness. On the other hand, autopsy revealed severe LD to be necrosis or abscess of metastatic lesion. Therefore, we should pay attention to avoid complications such as rupture, and discontinue HAIC when severe LD appears.
Arai
K
K
Dept. of Surgery, Tokyo Metropolitan Komagome Hospital.
Kitamura
M
M
Iwasaki
Y
Y
D000368:Aged; D000369:Aged, 80 and over; D001794:Blood Pressure / Q000187:drug effects*; D016461:Chemoembolization, Therapeutic; D005260:Female; D006499:Hepatic Artery; D006801:Humans; D007261:Infusions, Intra-Arterial; D008099:Liver / Q000000981:diagnostic imaging* / Q000473:pathology; D008113:Liver Neoplasms / Q000000981:diagnostic imaging* / Q000556:secondary / Q000628:therapy*; D008297:Male; D008863:Microspheres; D008875:Middle Aged; D009638:Norepinephrine / Q000627:therapeutic use*; D011856:Radiographic Image Enhancement; D013274:Stomach Neoplasms / Q000473:pathology*; D013566:Sympathomimetics / Q000627:therapeutic use*; D014057:Tomography, X-Ray Computed
D013566:Sympathomimetics; D009638:Norepinephrine