Effects of 4'-chlordiazepam on glycemia and serum lipids in hyperlipidemic rats: interactions with PK 11195 and flumazenil.
In rats rendered hyperlipidemic by the interperitoneal injection of Triton WR-1339, the administration of 4'-chlorodiazepam, a selective agonist of the peripheral type of benzodiazepine (BZO) receptors evoked significant reductions of serum lipids. PK 11195, a specific antagonist of these receptors, partially inhibited these effects. Flumazenil, a selective antagonist of the central BZD receptors, enhanced the lipid lowering activity of 4'-chlorodiazepam.
Cuparencu
B
B
Department of Pharmacology, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Horák
J
J
D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology*; D001786:Blood Glucose / Q000032:analysis*; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D005442:Flumazenil / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D007546:Isoquinolines / Q000494:pharmacology*; D008055:Lipids / Q000097:blood*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000187:drug effects*
D001570:Benzodiazepinones; D001786:Blood Glucose; D000960:Hypolipidemic Agents; D007546:Isoquinolines; D008055:Lipids; D011963:Receptors, GABA-A; C028513:4'-chlorodiazepam; D005442:Flumazenil; C037850:PK 11195