[The use of gammaglobulin for preventing infection in stroke].
In the study the influence of giving gammaglobulin on the course of stroke was tested. The trial was double blind, with a control group and with a randomised administering of gammaglobulin and placebo. The condition for including a patient in the trial was clinical diagnosis of stroke, period of time from the onset not longer than five days, and the absence of both clinical and laboratory features of infection. 36 patients were given gammaglobulin (Veinoglobulin Institut Merieux) in 10 g doses at 3-day intervals, 35 patients were given placebo: 10g of albumin. The clinical follow-up lasted 30 days. Three patients from the gammaglobulin group and nine patients from the placebo group died. Administration of gammaglobulin decreased the tisc of death by 74%. The improvement of neurological deficit in 30-day survivals in the treated group was more expressed than in the placebo group. The total number of infections, number of days with increased temperature, number and time of given antibiotics were comparable in both groups. The results obtained suggest that prophylactic treatment with gammaglobulin does not prevent infections but their course is milder with consequent better clinical improvement and lower mortality.
Palasik
W
W
Kliniki Chorób Naczyniowych.
Popow
J
J
Lechowicz
W
W
Fiszer
U
U
Członkowska
A
A
D000368:Aged; D002561:Cerebrovascular Disorders / Q000188:drug therapy* / Q000517:prevention & control*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D010919:Placebos; D012189:Retrospective Studies; D016896:Treatment Outcome; D005719:gamma-Globulins / Q000009:adverse effects / Q000627:therapeutic use*
D010919:Placebos; D005719:gamma-Globulins
Gammaglobulina w zapobieganiu infekcjom u chorych z udarem mózgowym.