Advances in glyoxalase research. Glyoxalase expression in malignancy, anti-proliferative effects of methylglyoxal, glyoxalase I inhibitor diesters and S-D-lactoylglutathione, and methylglyoxal-modified protein binding and endocytosis by the advanced glycation endproduct receptor.
Thornalley
P J
PJ
Department of Chemistry and Biological Chemistry, University of Essex, Colchester, UK.
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D004705:Endocytosis / Q000187:drug effects / Q000502:physiology; D004952:Esters / Q000494:pharmacology; D005978:Glutathione / Q000031:analogs & derivatives* / Q000494:pharmacology; D017127:Glycation End Products, Advanced / Q000378:metabolism*; D006801:Humans; D007791:Lactoylglutathione Lyase / Q000037:antagonists & inhibitors / Q000378:metabolism / Q000502:physiology*; D009369:Neoplasms / Q000188:drug therapy / Q000201:enzymology* / Q000378:metabolism; D011485:Protein Binding / Q000187:drug effects; D011765:Pyruvaldehyde / Q000494:pharmacology*; D011956:Receptors, Cell Surface / Q000378:metabolism; D013869:Thiolester Hydrolases / Q000378:metabolism / Q000502:physiology*; D000099301:Hydroxyacylglutathione Hydrolase
D000970:Antineoplastic Agents; D004952:Esters; D005978:Glutathione; D017127:Glycation End Products, Advanced; D007791:Lactoylglutathione Lyase; D011765:Pyruvaldehyde; D011956:Receptors, Cell Surface; D013869:Thiolester Hydrolases; D000099301:Hydroxyacylglutathione Hydrolase; C013585:S-lactoylglutathione