title: Spontaneous mutant frequency of lacZ gene in spleen of transgenic mouse increases with age.
abstract: Spontaneous mutant frequency of lacZ gene in spleen of transgenic MutaTM mouse was examined at different ages. It was (3.2 +/- 1.3 (SD)) x 10(-5) at newborn and increased almost linearly with age up to (8.3 +/- 1.8) x 10(-5) at one year. Since the mutation of the gene is not likely to be subject to selection in vivo, the data support the idea that spontaneous mutation takes place throughout aging process and accumulates with age if not selected out by cell death.
authors.affiliation: Department of Radiation Research, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ono
authors.forename: Y
authors.initials: Y
authors.lastname: Miyamura
authors.forename: H
authors.initials: H
authors.lastname: Ikehata
authors.forename: H
authors.initials: H
authors.lastname: Yamanaka
authors.forename: A
authors.initials: A
authors.lastname: Kurishita
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Nohmi
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: T
authors.initials: T
authors.lastname: Sofuni
mesh_terms: D000375:Aging / Q000235:genetics*; D000818:Animals; D005260:Female; D007041:Hypoxanthine Phosphoribosyltransferase / Q000235:genetics; D007763:Lac Operon; D008297:Male; D051379:Mice; D008822:Mice, Transgenic / Q000235:genetics; D009154:Mutation / Q000235:genetics*; D013154:Spleen / Q000378:metabolism*; D019076:Transgenes
chemical_list: D007041:Hypoxanthine Phosphoribosyltransferase