[Redistribution of Ca2+ ions in Ehrlich ascites carcinoma cells under the action of deoxyglucose and inhibitors of the intracellular Ca2+- transporting system].
Changes in free cytoplasmic Ca2+ ([Ca2+]i) in Ehrlich ascites tumour cells were studied under the effect of deoxyglucose and agents which modify transmembrane Ca2+ fluxes. It was shown that the reason for deoxyglucose-induced [Ca2+]i increase in Ca2+ release from internal stores and the influx from the external medium. Mitochondrial metabolic inhibitors (oligomycin+KCN, oligomycin++uncouplers of oxidative phosphorylation) induce themselves some rise in [Ca2+]i and increase the deoxyglucose effect on [Ca2+]i significantly. The conclusion was made that mitochondria can participate in cytosolic Ca2+ regulation and Ca2+ redistribution in tumour cells.
Evtodienko
Iu V
IuV
Teplova
V V
VV
Sidash
S S
SS
Voĭtchak
L
L
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D002286:Carcinoma, Ehrlich Tumor / Q000378:metabolism*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D003847:Deoxyglucose / Q000494:pharmacology*; D017136:Ion Transport; D009840:Oligomycins / Q000494:pharmacology; D010085:Oxidative Phosphorylation; D011190:Potassium Cyanide / Q000494:pharmacology; D013729:Terpenes / Q000494:pharmacology; D019284:Thapsigargin; D014407:Tumor Cells, Cultured
D009840:Oligomycins; D013729:Terpenes; D019284:Thapsigargin; D003847:Deoxyglucose; D000252:Calcium-Transporting ATPases; D011190:Potassium Cyanide; D002118:Calcium
Pereraspredelenie ionov Ca2+ v kletkakh astsitnoĭ kartsinomy Erlikha pod deĭstviem dezoksigliukozy i ingibitorov vnutrikletochnykh Ca2+-transportiruiushchikh sistem.