Immunophilins and the nervous system.
The search for immunosuppressant drugs to increase the success of organ transplantation led to the discovery of the immunophilins, proteins that interface with a range of signal transduction systems inside cells, especially in the nervous and immune systems. Here we review how these interesting molecules work and consider their therapeutic potential.
Snyder
S H
SH
Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Sabatini
D M
DM
D000591:Amino Acid Isomerases / Q000502:physiology*; D000818:Animals; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000502:physiology; D002352:Carrier Proteins / Q000502:physiology*; D004268:DNA-Binding Proteins / Q000502:physiology*; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D007166:Immunosuppressive Agents / Q000494:pharmacology*; D009424:Nervous System Physiological Phenomena; D019696:Peptidylprolyl Isomerase; D010749:Phosphoprotein Phosphatases / Q000502:physiology; D011090:Polyenes / Q000494:pharmacology; D015398:Signal Transduction; D020123:Sirolimus; D022021:Tacrolimus Binding Proteins
D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D004268:DNA-Binding Proteins; D006360:Heat-Shock Proteins; D007166:Immunosuppressive Agents; D011090:Polyenes; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases; D000591:Amino Acid Isomerases; D022021:Tacrolimus Binding Proteins; D019696:Peptidylprolyl Isomerase; D020123:Sirolimus