Interferon or hepatitis C virus induced autoimmune aplastic anemia and severe thrombocytopenia? A case report.
We describe a case of aplastic anemia with severe thrombocytopenia in a patient affected by chronic active hepatitis C treated with interferon. The hematologic alterations did not disappear after suspension of interferon or after the ensuing steroid treatment. Administration of cyclosporin markedly improved the hematologic parameters and serum transaminase levels.
Siciliano
R
R
Istituto di Medicina Interna e Geriatria, Università degli Studi di Catania.
Trovato
B A
BA
Seminara
G
G
Giustolisi
V
V
Malaguarnera
M
M
D000741:Anemia, Aplastic / Q000175:diagnosis / Q000209:etiology*; D001327:Autoimmune Diseases / Q000175:diagnosis / Q000209:etiology*; D001707:Biopsy, Needle; D001853:Bone Marrow / Q000473:pathology; D001842:Bone and Bones / Q000473:pathology; D002908:Chronic Disease; D005260:Female; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D007370:Interferon Type I / Q000009:adverse effects*; D008875:Middle Aged; D011994:Recombinant Proteins; D013921:Thrombocytopenia / Q000175:diagnosis / Q000209:etiology*; D013997:Time Factors
D007370:Interferon Type I; D011994:Recombinant Proteins