Immunomodulatory effects of alpha interferon and thymostimulin in patients with neoplasias.
In this report, we have evaluated the immunological effects following administration of alpha interferon (IFN-alpha) in combination with thymostimulin (TP-1), as well as of IFN-alpha and TP-1 alone in patients with neoplasias who underwent surgery and were subsequently treated with conventional chemotherapy. Data suggest that the combination of IFN-alpha and TP-1 is the most effective in the up-regulation of some immune parameters such as the CD4(+)-CD8+ cell-dependent antibacterial activity. Since this immune function plays an important role in the host protection against different targets such as invading microorganisms and/or neoplastic cells, the administration of TP-1-IFN-alpha is advisable for patients with neoplasias under chemotherapy.
Munno
I
I
Istituto di Microbiologia, University of Bari, Italy.
Marinaro
M
M
Gesario
A
A
Cannuscio
B
B
Michel
Y
Y
Paulling
E
E
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology*; D001943:Breast Neoplasms / Q000276:immunology / Q000628:therapy; D002277:Carcinoma / Q000276:immunology / Q000628:therapy; D015179:Colorectal Neoplasms / Q000276:immunology / Q000628:therapy; D005260:Female; D006801:Humans; D007167:Immunotherapy; D016898:Interferon-alpha / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D013949:Thymus Extracts / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D016898:Interferon-alpha; D013949:Thymus Extracts; C031407:thymostimulin