title: Pulmonary hypertension in rats. 2. Role of interleukin-6.
abstract: We administered human interleukin (IL)-6 to rats to examine whether it is implicated in the development of pulmonary hypertension (PH). The rats injected with IL-6 developed PH as determined by the weight ratio of the right ventricle to the left ventricle+septum. This ratio decreased with the appearance of IgG anti-human IL-6 antibody. Histologically we observed in the lungs, luminal occlusion of small muscular arteries, capillaries filled with fibrin thrombi, and localized hemorrhage. IL-6 increased the number of platelets, and the number of platelets correlated with the extent of PH. Thus, it seems likely that (IL-6) is involved in the formation of PH in this model.
authors.affiliation: Department of Internal Medicine II, Fukushima Medical College, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miyata
authors.forename: F
authors.initials: F
authors.lastname: Sakuma
authors.forename: A
authors.initials: A
authors.lastname: Yoshimura
authors.forename: H
authors.initials: H
authors.lastname: Ishikawa
authors.forename: T
authors.initials: T
authors.lastname: Nishimaki
authors.forename: R
authors.initials: R
authors.lastname: Kasukawa
mesh_terms: D000818:Animals; D006352:Heart Ventricles / Q000473:pathology; D006470:Hemorrhage; D006801:Humans; D006976:Hypertension, Pulmonary / Q000097:blood / Q000139:chemically induced / Q000276:immunology* / Q000503:physiopathology; D007074:Immunoglobulin G / Q000097:blood; D015850:Interleukin-6 / Q000276:immunology* / Q000633:toxicity; D008168:Lung / Q000473:pathology; D008297:Male; D009929:Organ Size; D010976:Platelet Count; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007074:Immunoglobulin G; D015850:Interleukin-6