MRI assessment of the blood-brain barrier in a hamster model of scrapie.
Magnetic resonance (MR) imaging in combination with gadolinium-diethylenetriaminepenta-acetic acid (Gd-DTPA) enhancement was used to investigate the integrity of the blood-brain barrier in a hamster model of scrapie (263K) during the clinical phase of the disease. The post Gd-DTPA images of the infected hamster brain showed marked enhancement, which was not present in control animals. These results suggest that blood-brain barrier function is disrupted in the clinically-affected animal.
Chung
Y L
YL
Robert Steiner MR Unit, Royal Postgraduate Medical School, Hammersmith Hospital, London.
Williams
A
A
Beech
J S
JS
Williams
S C
SC
Bell
J D
JD
Cox
I J
IJ
Hope
J
J
D000818:Animals; D001812:Blood-Brain Barrier / Q000502:physiology*; D006224:Cricetinae; D004195:Disease Models, Animal; D005069:Evaluation Studies as Topic; D005682:Gadolinium; D019786:Gadolinium DTPA; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds; D004369:Pentetic Acid / Q000031:analogs & derivatives; D011522:Protons; D012608:Scrapie / Q000175:diagnosis*
D009942:Organometallic Compounds; D011522:Protons; D004369:Pentetic Acid; D005682:Gadolinium; D019786:Gadolinium DTPA