Calcium regulation of gene expression in neurons: the mode of entry matters.
Ca2+ entry into neurons is one of the major effectors of stimulus-induced physiological change. Ca2+ can enter neurons through a number of different voltage-gated and ligand-gated channels. Depending on the route of entry, Ca2+ stimulates distinct intracellular signaling pathways, which activate different sets of genes, resulting in alternative physiological outcomes for the cell. These recent results suggest that the specific effect of a single biochemical second messenger can vary as a consequence of its route of entry into the cell.
Gallin
W J
WJ
Department of Biological Sciences, University of Alberta, Edmonton, Canada.
Greenberg
M E
ME
D000818:Animals; D002118:Calcium / Q000502:physiology*; D015870:Gene Expression; D008959:Models, Neurological; D009474:Neurons / Q000502:physiology*; D016716:PC12 Cells; D051381:Rats; D015398:Signal Transduction / Q000235:genetics*
D002118:Calcium