[Abnormal expression and clinical significance of mutation p53 gene on human bladder cancer].
In order to study the relationships between the mutant p53 gene and human bladder cancer, the authors used in situ hybridization to detect 30 of bladder cancer and 4 of normal bladder samples. The results showed that p53 gene positive rate of mRNA was 23.3% in cancer patient, and all negative in normal-bladder. The positive rate was significantly different in pathological grading and clinical stages of carcinoma (P < 0.05). It suggests that the mutant p53 gene participats in transformation of carcinoma and may be used as a tumor marker for determinating invasiveness and prognosis of bladder carcinoma.
Xie
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X
General Hospital of Shenyang Unit of People's Liberation Army.
Yu
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M
Wu
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Q
D002295:Carcinoma, Transitional Cell / Q000235:genetics*; D015342:DNA Probes; D015870:Gene Expression; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D017354:Point Mutation; D011379:Prognosis; D012333:RNA, Messenger / Q000378:metabolism; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D015342:DNA Probes; D012333:RNA, Messenger