Squamous cell carcinoma of the ureter with marked leukocytosis producing granulocyte colony-stimulating factor.
This paper describes a case of squamous cell carcinoma (SCC) of the ureter which showed marked leukocytosis without any evidence of infection and hematologic malignancies. The level of serum granulocyte colony-stimulating factor (G-CSF) assayed by enzyme immunoassay increased and the immunohistochemical staining of the ureter tumor showed the presence of G-CSF in tumor cells. These findings indicate that SCC of the ureter produced G-CSF which stimulated leukocyte production in bone marrow and resulted in leukocytosis. To our knowledge, this is the first report of ureter tumor with leukocytosis producing G-CSF.
Morita
T
T
Department of Urology, Jichi Medical School, Tochigi, Japan.
Izumi
T
T
Shinohara
N
N
Tokue
A
A
D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000150:complications* / Q000378:metabolism* / Q000473:pathology; D016179:Granulocyte Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D007150:Immunohistochemistry; D007964:Leukocytosis / Q000150:complications*; D008297:Male; D014516:Ureteral Neoplasms / Q000150:complications* / Q000378:metabolism* / Q000473:pathology
D016179:Granulocyte Colony-Stimulating Factor