title: Effects of furosemide, exercise, and atropine on tracheal mucus transport rate in horses.
abstract: Effects of furosemide, exercise, and atropine on tracheal mucus transport rate (TMTR) in horses were investigated. Atropine (0.02 mg/kg of body weight) administered IV or by aerosolization significantly (P < 0.05) decreased TMTR at 60, but not at 30 minutes after its administration in standing horses. Furosemide (1.10 mg/kg, IV) did not have any significant effect on TMTR when measured at 2 or 4 hours after its administration in standing horses. Exercise alone or furosemide (1.10 mg/kg, IV) administration followed 4 hours later by exercise did not alter TMTR, compared with values for standing control or exercised horses administered saline solution. Atropine (0.02 mg/kg, IV) administered after exercise significantly (P < 0.05) decreased TMTR, compared with values for no exercise standing controls, for exercise after administration of saline solution, and for furosemide and exercise.
authors.affiliation: New Bolton Center, Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Kennett Square, 19348-1692, USA.
authors.forename: A D
authors.initials: AD
authors.lastname: Maxson
authors.forename: L R
authors.initials: LR
authors.lastname: Soma
authors.forename: L L
authors.initials: LL
authors.lastname: May
authors.forename: J A
authors.initials: JA
authors.lastname: Martini
mesh_terms: D000336:Aerosols; D000818:Animals; D001285:Atropine / Q000008:administration & dosage / Q000494:pharmacology*; D005080:Exercise Test / Q000662:veterinary; D005260:Female; D005665:Furosemide / Q000008:administration & dosage / Q000494:pharmacology*; D006736:Horses / Q000502:physiology*; D007275:Injections, Intravenous; D008297:Male; D009092:Mucous Membrane / Q000187:drug effects / Q000502:physiology; D009919:Orchiectomy; D005082:Physical Exertion; D014132:Trachea / Q000502:physiology*
chemical_list: D000336:Aerosols; D001285:Atropine; D005665:Furosemide