Proteolysis. The proteasome: a protein-degrading organelle?
The crystal structure of the proteasome suggests that degradation of ubiquitin-protein conjugates is achieved by unfolding the protein substrate and translocating it through a channel into a peptidase-containing chamber.
Rubin
D M
DM
Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
Finley
D
D
D001692:Biological Transport; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D006868:Hydrolysis; D009097:Multienzyme Complexes / Q000737:chemistry / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013822:Thermoplasma / Q000201:enzymology; D014452:Ubiquitins / Q000378:metabolism*
D009097:Multienzyme Complexes; D011506:Proteins; D014452:Ubiquitins; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex