Migraine to the year 2000.
Although migraine is inextricably bound up with 5-hydroxytryptamine and its many receptors, its precise mechanisms continue to elude us and there is still no clear evidence supporting either a vascular or neurogenic hypothesis unequivocally. What appears to distinguish migraine sufferers from normal subjects may be a greater gentic sensitivity to a wide variety of triggering agents--even including nitric oxide and the migraine aura, as well as those more usually recognized. Attention is drawn to a possible role for neurotrophins, such as the hyperalgesia-provoking nerve growth factor (NGF) in particular, as well as basic fibroblast growth factor (bFGF) and brain-derived neurotrophic factor (BDNF).
Sandler
M
M
Department of Chemical Pathology, Queen Charlotte's and Chelsea Hospital, London, UK.
D006801:Humans; D008881:Migraine Disorders / Q000503:physiopathology*; D011985:Receptors, Serotonin / Q000378:metabolism; D012701:Serotonin / Q000378:metabolism; D018170:Sumatriptan / Q000378:metabolism
D011985:Receptors, Serotonin; D012701:Serotonin; D018170:Sumatriptan