A region of the 75 kDa neurotrophin receptor homologous to the death domains of TNFR-I and Fas.
Members of the NTR/TNFR family mediate apoptosis in many tissues, yet sequence homology has not been detected in their intracellular domains except for a 'death domain' in TNFR-I and Fas. Here, a region of the 75 kDa neurotrophin receptor (NTR) has been aligned with this apoptosis-inducing motif. Peptides at the carboxyl terminus of each domain potentially form amphiphilic helices, one of which (in NTR) resembles mastoparan, a G-protein activating peptide. Molecular models of three death-region peptides suggest that observed sequence similarities reflect a common structure, perhaps capable of undergoing an induced coil to helix transition.
Chapman
B S
BS
Department of Pharmaceutical Chemistry, School of Pharmacy, University of California, San Francisco 94143-0446, USA.
D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000737:chemistry*; D017209:Apoptosis; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008969:Molecular Sequence Data; D010455:Peptides; D017433:Protein Structure, Secondary; D020800:Receptor, Nerve Growth Factor; D018013:Receptors, Neuropeptide / Q000737:chemistry*; D018124:Receptors, Tumor Necrosis Factor / Q000737:chemistry*; D047888:Receptors, Tumor Necrosis Factor, Type I; D017386:Sequence Homology, Amino Acid; D014862:Wasp Venoms / Q000737:chemistry; D019014:fas Receptor / Q000737:chemistry
D015703:Antigens, CD; D036341:Intercellular Signaling Peptides and Proteins; D010455:Peptides; D020800:Receptor, Nerve Growth Factor; D018013:Receptors, Neuropeptide; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D014862:Wasp Venoms; D019014:fas Receptor; C037500:mastoparan