title: [Ergotamine-induced anorectal lesions].
abstract: During the past 10 years several reports on perianal ulcerations secondary to chronic use of ergotamine suppositories were published. The present case reports deal with 2 female patients who used ergotamine suppositories for treatment of sick head aches for several years. In both cases the suppositories were used chronically. The first patient, a 60 year old woman has been treated repeatedly because of recurrent perianal ulcerations. An infection and a carcinoma could be excluded. The diagnosis of ergotamine induced ulcerations could be suspected only after a detailed work up of the patients past medical history and interview of family members. The ulcerations healed within a few months after broad excision and withdrawal of the medication. The second patient, a 51 year old woman complained of severe obstipation which occurred within a few months. The investigations showed a circular stenosis in the lower third of the rectum. The patient was treated successfully by bougienage under general anaesthesia. These case reports demonstrate the difficulties in diagnosis such lesions and emphasize the importance of a close medical follow-up when ergotamine suppositories are used for treatment of migraine. Whenever possible, a continuous treatment should be avoided.
authors.affiliation: Klinik für Abdominal-und Transplantationschirurgie, Medizinische Hochschule Hannover.
authors.forename: P
authors.initials: P
authors.lastname: Lamesch
authors.forename: R
authors.initials: R
authors.lastname: Raab
authors.forename: H J
authors.initials: HJ
authors.lastname: Meyer
mesh_terms: D001003:Anal Canal / Q000473:pathology / Q000601:surgery; D001004:Anus Diseases / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D004878:Ergotamine / Q000008:administration & dosage / Q000009:adverse effects*; D004881:Ergotism / Q000473:pathology / Q000601:surgery*; D005260:Female; D006801:Humans; D007415:Intestinal Obstruction / Q000139:chemically induced / Q000473:pathology / Q000601:surgery; D008875:Middle Aged; D008881:Migraine Disorders / Q000188:drug therapy*; D012002:Rectal Diseases / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery; D012007:Rectum / Q000473:pathology / Q000601:surgery; D012883:Skin Ulcer / Q000139:chemically induced* / Q000473:pathology / Q000601:surgery
chemical_list: D004878:Ergotamine
vernacular_title: Ergotamininduzierte anorectale Läsionen.