Cholesterol and the coronary endothelium.
The root causes of atherosclerosis lie in cellular events that precede the clinical presentation of the disease by many years. The initiating events centre around the response of endothelial cells to chronic injury, such as that sustained in hypercholesterolaemia. These responses involve the activation, attachment and migration of leucocytes and platelets.
Knight
C J
CJ
Department of Cardiology, Royal Brompton Hospital, London, UK.
Warren
J B
JB
D000818:Animals; D002784:Cholesterol / Q000378:metabolism*; D003324:Coronary Artery Disease / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D003331:Coronary Vessels / Q000378:metabolism* / Q000648:ultrastructure; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000648:ultrastructure; D006487:Hemostasis; D006801:Humans; D009000:Monocytes / Q000378:metabolism / Q000648:ultrastructure
D002784:Cholesterol