title: [Inhibitory effect of interleukin-1 beta on insulin release from isolated rat pancreatic islets and the reversal action of testosterone].
abstract: Insulin release from pancreatic islet cells of neonatal rats could be markedly inhibited by a previous incubation of cells with interleukin-1 beta (5-20 U/ml) for 20 h even under high glucose (20 mmol/L) stimulation. This inhibitory effect of IL-1 beta on insulin release could be reversed by testosterone (10(-10) mol/L), which was accompanied by an increase of the insulin content in islet cells.
authors.affiliation: Department of Physiology, Beijing Medical University.
authors.forename: H L
authors.initials: HL
authors.lastname: Fang
authors.forename: L
authors.initials: L
authors.lastname: Wang
authors.forename: Y K
authors.initials: YK
authors.lastname: Yang
authors.forename: W Y
authors.initials: WY
authors.lastname: Zhu
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D007375:Interleukin-1 / Q000494:pharmacology*; D053583:Interleukin-1beta; D007515:Islets of Langerhans / Q000166:cytology / Q000378:metabolism*; D010446:Peptide Fragments / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013739:Testosterone / Q000494:pharmacology*
chemical_list: D007328:Insulin; D007375:Interleukin-1; D053583:Interleukin-1beta; D010446:Peptide Fragments; C052994:interleukin-1beta (163-171); D013739:Testosterone