title: Intestinal intraluminal continuity is a prerequisite for the distal bowel motility response to feeding.
abstract: BACKGROUND
  We wanted to elucidate further the regulation of the intestinal motility response to feeding.
  
  
  METHODS
  After intraduodenal administration of an oleate solution, mimicking a meal, the distal bowel motility and the plasma levels of bile acids, cholecystokinin (CCK), and neurotensin were monitored in patients operated on with restorative proctocolectomy (n = 4) or low anterior resection of the rectum (n = 4). Investigations were performed both with and without a diverting loop ileostomy.
  
  
  RESULTS
  Intraduodenal sodium oleate elicited a prompt and significant increase in distal bowel motility. The motility response failed to appear when the luminal flow was diverted by a loop ileostomy. An increase in plasma CCK preceded the motility increase, but CCK was increased also in patients with a loop ileostomy. Whereas plasma bile acid levels were significantly increased after 30-45 min (p < 0.05), both with and without a loop ileostomy, neurotensin levels were not affected.
  
  
  CONCLUSIONS
  Intestinal continuity is a prerequisite for the distal bowel motility response, indicating that apart from other possible mechanisms, luminal factors are involved in the regulation of intestinal motility.
authors.affiliation: Dept. of Surgery II, University of Göteborg, Sahlgrenska sjukhuset, Sweden.
authors.forename: T
authors.initials: T
authors.lastname: Hallgren
authors.forename: T
authors.initials: T
authors.lastname: Oresland
authors.forename: P
authors.initials: P
authors.lastname: Cantor
authors.forename: S
authors.initials: S
authors.lastname: Fasth
authors.forename: L
authors.initials: L
authors.lastname: Hultén
mesh_terms: D000328:Adult; D000368:Aged; D002766:Cholecystokinin / Q000097:blood; D004435:Eating / Q000502:physiology; D005260:Female; D005769:Gastrointestinal Motility / Q000502:physiology; D006801:Humans; D007081:Ileostomy; D007322:Instillation, Drug; D008297:Male; D008875:Middle Aged; D009496:Neurotensin / Q000097:blood; D019301:Oleic Acid; D009829:Oleic Acids / Q000008:administration & dosage* / Q000494:pharmacology; D016737:Proctocolectomy, Restorative; D011350:Proctocolitis / Q000601:surgery; D012004:Rectal Neoplasms / Q000601:surgery; D012007:Rectum / Q000601:surgery
chemical_list: D009829:Oleic Acids; D019301:Oleic Acid; D009496:Neurotensin; C013173:osteum; D002766:Cholecystokinin