A personal computer-based system for parallel line analysis of bioassay data.
A program is described for symmetric parallel line analysis of bioassay data with a logistic dose-response relationship. Dose-response relationship is transformed to semilog or log-log. A regression line can be calculated for the dose-response curve for standard and test samples, and produces potency estimate of test sample preparation relative to the standard preparation based on parallel-line bioassay statistical methods [3,4], together with detailed analysis of variance, estimates of slope, intercept and chi 2 test which permits a very sensitive test for linearity and parallelism of standard and test sample and facilitates detection of 'outliers', i.e. samples exhibiting non-parallelism. The general comparison of dose-response relationships produced by the program are a feature of particular interest.
Iznaga
N
N
Center of Molecular Immunology, Havana, Cuba.
Núñez
G
G
Solozabal
J
J
Morales
A
A
Artaza
E
E
Rubio
R
R
Cardenas
E
E
D000704:Analysis of Variance; D001681:Biological Assay; D001777:Blood Coagulation; D016009:Chi-Square Distribution; D003196:Computer Graphics; D003626:Data Display; D003627:Data Interpretation, Statistical; D004305:Dose-Response Relationship, Drug; D008432:Mathematical Computing; D008838:Microcomputers; D008962:Models, Theoretical; D012044:Regression Analysis; D012984:Software