title: REM sleep deprivation treatment enhances the effect of clozapine in the forced swimming test.
abstract: 1. Effect of REM sleep (REMs) deprivation treatment on clozapine response in the forced swimming test was investigated. 2. Clozapine significantly increased the swimming activity in REMs-deprived mice at a dose of 5 mg/kg (i.p.) which did not affect the activities in the control groups. 3. Physostigmine (0.3 mg/kg, i.p.), an acetylcholinesterase inhibitor, blocked the increasing effect of 5 mg/kg clozapine on swimming activity in REMs-deprived animals. 4. These results suggest that the REMs deprivation treatment-induced enhancement of effect of clozapine on swimming activity is mediated by the functional change of central cholinergic system following the treatment.
authors.affiliation: Division of Pharmacology, Toyama Medical and Pharmaceutical University, Japan.
authors.forename: W
authors.initials: W
authors.lastname: Asakura
authors.forename: K
authors.initials: K
authors.lastname: Matsumoto
authors.forename: H
authors.initials: H
authors.lastname: Watanabe
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D002799:Cholinergic Fibers; D003024:Clozapine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D010830:Physostigmine / Q000494:pharmacology; D012895:Sleep, REM; D013550:Swimming; D015016:Yohimbine / Q000494:pharmacology
chemical_list: D015016:Yohimbine; D010830:Physostigmine; D003024:Clozapine