title: NMR structure of an inhibitory R2 C-terminal peptide bound to mouse ribonucleotide reductase R1 subunit.
abstract: The structure of peptide N-AcYTLDADF when bound to the large subunit of mouse ribonucleotide reductase has been elucidated by transfer NOE. This structure suggests a general design for type 1 RR inhibitors.
authors.forename: A
authors.initials: A
authors.lastname: Fisher
authors.forename: P B
authors.initials: PB
authors.lastname: Laub
authors.forename: B S
authors.initials: BS
authors.lastname: Cooperman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015195:Drug Design; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000737:chemistry*; D012264:Ribonucleotide Reductases / Q000037:antagonists & inhibitors* / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity
chemical_list: C096714:N-acetyltyrosyl-threonyl-leucyl-aspartyl-alanyl-aspartyl-phenylalanine; D009842:Oligopeptides; D012264:Ribonucleotide Reductases