[The role of protein kinase C and muscarinic cholinoreceptors in vasopressin-stimulated water transport].
The role of protein kinase C (PKC) in the control of vasopressin-stimulated water transport in the frog urinary bladder and its modulation by M2-agonist oxotremorine has been studied. Using the PKC inhibitor, staurosporine we showed that PKC in the region pf the basal membrane suppressed vasopressin-stimulated water transport, whereas PKC in the apical region potentiated this transport. It was also found that from the two types of oxotremorine action on stimulated water transport determined by its concentration only inhibition is mediated through PKC.
Bagrov
Ia Iu
IaIu
Dmitrieva
N I
NI
Manusova
N B
NB
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D001127:Arginine Vasopressin / Q000494:pharmacology*; D001692:Biological Transport / Q000187:drug effects; D004791:Enzyme Inhibitors / Q000494:pharmacology; D066298:In Vitro Techniques; D018721:Muscarinic Agonists / Q000494:pharmacology; D010095:Oxotremorine / Q000494:pharmacology; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000187:drug effects / Q000502:physiology*; D011896:Rana temporaria; D011976:Receptors, Muscarinic / Q000187:drug effects / Q000502:physiology*; D019311:Staurosporine; D013268:Stimulation, Chemical; D001743:Urinary Bladder / Q000187:drug effects / Q000378:metabolism; D014867:Water / Q000378:metabolism*
D000470:Alkaloids; D004791:Enzyme Inhibitors; D018721:Muscarinic Agonists; D011976:Receptors, Muscarinic; D014867:Water; D001127:Arginine Vasopressin; D010095:Oxotremorine; D011493:Protein Kinase C; D019311:Staurosporine
O roli proteinkinazy C i muskarinovykh kholinoretseptorov v stimulirovannom vazopressinom vodnom transporte.