title: Proteolysis. The proteasome: a protein-degrading organelle?
abstract: The crystal structure of the proteasome suggests that degradation of ubiquitin-protein conjugates is achieved by unfolding the protein substrate and translocating it through a channel into a peptidase-containing chamber.
authors.affiliation: Department of Cell Biology, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: D M
authors.initials: DM
authors.lastname: Rubin
authors.forename: D
authors.initials: D
authors.lastname: Finley
mesh_terms: D001692:Biological Transport; D003546:Cysteine Endopeptidases / Q000737:chemistry / Q000378:metabolism*; D006868:Hydrolysis; D009097:Multienzyme Complexes / Q000737:chemistry / Q000378:metabolism*; D015388:Organelles / Q000378:metabolism*; D046988:Proteasome Endopeptidase Complex; D011487:Protein Conformation; D017510:Protein Folding; D011506:Proteins / Q000378:metabolism*; D012441:Saccharomyces cerevisiae / Q000201:enzymology; D013822:Thermoplasma / Q000201:enzymology; D014452:Ubiquitins / Q000378:metabolism*
chemical_list: D009097:Multienzyme Complexes; D011506:Proteins; D014452:Ubiquitins; D003546:Cysteine Endopeptidases; D046988:Proteasome Endopeptidase Complex