title: Bruceosides D, E, and F, three new cytotoxic quassinoid glucosides from Brucea javanica.
abstract: Three new quassinoid glucosides, bruceosides D [1], E [2], and F [3], were isolated from Brucea javanica, and their structures were elucidated by spectral evidence and chemical transformation to known compounds. Compounds 1-3 show selective cytotoxicity in the leukemia and non-small cell lung, colon, CNS, melanoma, and ovarian cancer cell lines with log GI50 values in the range of -4.14 to -5.72.
authors.affiliation: Department of Interdisciplinary Studies of Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Higashihiroshima, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Ohnishi
authors.forename: N
authors.initials: N
authors.lastname: Fukamiya
authors.forename: M
authors.initials: M
authors.lastname: Okano
authors.forename: K
authors.initials: K
authors.lastname: Tagahara
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D005260:Female; D005900:Glaucarubin / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D013058:Mass Spectrometry; D008745:Methylation; D010946:Plants, Medicinal / Q000737:chemistry*; D036702:Quassins; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014407:Tumor Cells, Cultured
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D036702:Quassins; C095783:bruceoside D; C095784:bruceoside E; C095785:bruceoside F; D005900:Glaucarubin