title: Preservation of the lower esophageal sphincter during total gastrectomy for gastric cancer to prevent postoperative reflux esophagitis.
abstract: The lower esophageal sphincter (LES) is usually removed during total gastrectomy to successfully perform a curative operation. In this study, the preservation of the LES in curative total gastrectomy was attempted to reduce the reflux. An experimental study using dogs has revealed that the high-pressure zone of the LES can be preserved by making a resection at the gastroesophageal junction, which thus helps to protect the reflux. A previous clinicopathological study revealed that the LES can be preserved without any fear of recurrence at the resection site, if the tumor is located more than 2.0 cm and 3.0 cm from the gastroesophageal junction to the oral margin in node-negative and -positive cases, respectively. Clinically, 8 patients underwent an LES-preserving total gastrectomy [LES(+) gastrectomy] while 19 had an LES(-) gastrectomy in the same period. Of the five LES(+) cases examined, all showed a high pressure zone, whereas none of the four LES(-) cases examined showed such a high-pressure zone after the operation. Endoscopic examination showed that only one of the seven LES(+) cases but six of nine LES(-) cases revealed esophagitis.
authors.affiliation: Department of Surgical Oncology, Hiroshima University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Hirai
authors.forename: S
authors.initials: S
authors.lastname: Saeki
authors.forename: K
authors.initials: K
authors.lastname: Matsuki
authors.forename: Y
authors.initials: Y
authors.lastname: Yamashita
authors.forename: T
authors.initials: T
authors.lastname: Iwata
authors.forename: A
authors.initials: A
authors.lastname: Yoshimoto
authors.forename: T
authors.initials: T
authors.lastname: Toge
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D002299:Cardia / Q000473:pathology / Q000503:physiopathology / Q000601:surgery; D004285:Dogs; D004942:Esophagitis, Peptic / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D004943:Esophagogastric Junction / Q000473:pathology / Q000503:physiopathology / Q000601:surgery*; D004945:Esophagoscopy; D005500:Follow-Up Studies; D005743:Gastrectomy / Q000379:methods*; D006801:Humans; D008207:Lymphatic Metastasis; D008365:Manometry; D009361:Neoplasm Invasiveness; D011178:Postgastrectomy Syndromes / Q000473:pathology / Q000503:physiopathology / Q000517:prevention & control*; D016896:Treatment Outcome