title: Mutagenic activity of p-toluenesulfonhydrazide.
abstract: Toluenesulfonhydrazide (TSH) is a high volume production chemical for which there is relatively little toxicological data. In this study, the mutagenic activity of TSH was determined in the Salmonella/mammalian microsome assay and the in vitro chromosomal aberration assay using Chinese hamster ovary cells. TSH induced gene mutations both with and without metabolic activation in the Salmonella/mammalian microsome assay but that it did not induce chromosomal aberrations in Chinese hamster ovary cells. The results of this study indicate that TSH is an in vitro mutagen and should be assessed for in vivo mutagenicity.
authors.affiliation: Mutagenesis Section, Department of National Health and Welfare, Ottawa, Ontario, Canada.
authors.forename: D H
authors.initials: DH
authors.lastname: Blakey
authors.forename: E R
authors.initials: ER
authors.lastname: Nestmann
authors.forename: J M
authors.initials: JM
authors.lastname: Bayley
authors.forename: K L
authors.initials: KL
authors.lastname: Maus
authors.forename: G R
authors.initials: GR
authors.lastname: Douglas
mesh_terms: D000818:Animals; D001711:Biotransformation / Q000187:drug effects; D016466:CHO Cells; D002478:Cells, Cultured; D002869:Chromosome Aberrations / Q000235:genetics*; D003198:Computer Simulation; D006224:Cricetinae; D008861:Microsomes / Q000187:drug effects / Q000378:metabolism; D009152:Mutagenicity Tests; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*; D009154:Mutation / Q000187:drug effects* / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D012475:Salmonella / Q000187:drug effects; D014105:Tosyl Compounds / Q000008:administration & dosage / Q000633:toxicity*
chemical_list: D009153:Mutagens; D014105:Tosyl Compounds; C002030:4-toluenesulfonyl hydrazide