title: A phase II study of carboplatin and vinorelbine as second-line treatment for advanced breast cancer.
abstract: Forty-one patients with advanced breast cancer were given carboplatin and vinorelbine as second-line therapy. Overall objective response rate was 46% (95% confidence interval 26-56%). Myelotoxicity was the most frequently observed toxic effect; grade III-IV leucopenia occurred in 46% of the patients. Our regimen is active as second-line chemotherapy for advanced breast cancer and warrants further evaluation.
authors.affiliation: Istituto di Medicina Interna, Università di Cagliari, Italy.
authors.forename: R V
authors.initials: RV
authors.lastname: Iaffaioli
authors.forename: A
authors.initials: A
authors.lastname: Tortoriello
authors.forename: G
authors.initials: G
authors.lastname: Facchini
authors.forename: M
authors.initials: M
authors.lastname: Santangelo
authors.forename: G
authors.initials: G
authors.lastname: De Sena
authors.forename: G
authors.initials: G
authors.lastname: Gesue
authors.forename: L
authors.initials: L
authors.lastname: Bucci
authors.forename: G
authors.initials: G
authors.lastname: Scaramellino
authors.forename: E
authors.initials: E
authors.lastname: Anastasio
authors.forename: A
authors.initials: A
authors.lastname: Finizio
mesh_terms: D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects / Q000627:therapeutic use*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology; D016190:Carboplatin / Q000008:administration & dosage / Q000009:adverse effects; D005260:Female; D005500:Follow-Up Studies; D016179:Granulocyte Colony-Stimulating Factor / Q000627:therapeutic use; D006801:Humans; D007970:Leukopenia / Q000139:chemically induced; D009362:Neoplasm Metastasis; D010689:Phlebitis / Q000139:chemically induced; D012074:Remission Induction; D016879:Salvage Therapy; D016896:Treatment Outcome; D014747:Vinblastine / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives; D000077235:Vinorelbine
chemical_list: D016179:Granulocyte Colony-Stimulating Factor; D014747:Vinblastine; D016190:Carboplatin; D000077235:Vinorelbine