High frequency oscillation in newborn infants with respiratory failure.
OBJECTIVE
To report ventilation strategies, survival and complications in 39 outborn infants treated with high frequency oscillatory ventilation (HFOV).


METHODS
Data were collected prospectively between 1 May 1992 and 31 December 1993 on all infants treated with HFOV who had severe respiratory failure despite optimal conventional ventilation.


RESULTS
Twenty-eight out of 39 (72%) survived. Of the 15 infants with birthweights < 1500 g, eight survived. Best survival rates were for infants with pulmonary interstitial emphysema with air leak (4/5) and for infants of birthweight > 1500 g with hyaline membrane disease (8/8), and meconium aspiration syndrome (7/7). Three infants deteriorated while on HFOV and required extracorporeal membrane oxygenation. Complications were: (i) development of pulmonary interstitial emphysema (1); (ii) recurrence of pneumothorax (3); (iii) hypotension (2); and (iv) bronchopulmonary dysplasia (9). One of the eight infants weighing < 1500 g who received HFOV in the first week of life developed periventricular haemorrhage.


CONCLUSIONS
The initial results of HFOV for severe failure were encouraging although a learning curve was encountered with its introduction.
McDougall
P N
PN
Department of Neonatology, Royal Children's Hospital, Parkville, Victoria, Australia.
Loughnan
P M
PM
Campbell
N T
NT
Hochmann
M
M
Timms
B J
BJ
Butt
W W
WW
D006612:High-Frequency Ventilation; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008171:Lung Diseases / Q000628:therapy; D011446:Prospective Studies; D012131:Respiratory Insufficiency / Q000628:therapy*; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome