Cingulate kindling in Senegalese baboons, Papio papio.
Kindling of the cingulate cortex in the Senegalese baboon Papio papio led to a protracted nonconvulsive seizure state characterized by immobile staring with (anterior cingulate, AC) or without (posterior cingulate, PC) widening of eyelids and neck flexion, followed by postictal visual searching behavior. Despite early bilateral spread of EEG discharges, ictal and interictal patterns remained persistently asymmetric. Secondary generalization was rapid and predictable once contralateral lower facial twitching associated with sustained adversion developed. After the primary site had been kindled, stimulation of the contralateral homotopic posterior cingulate cortex readily produced afterdischarge. However, it remained localized and kindling growth did not occur. The findings suggest that (a) the cingulate cortex can support nonconvulsive seizures; (b) cingulate seizures are accompanied by asymmetric convexity EEG discharges indicating its lateralized onset; (c) further evolution to convulsive seizures after kindling of cingulate cortex requires access to the ipsilateral frontocentral cortex responsible for facial twitching; and (d) the development of focal epileptogenesis at one cingulate site interferes with clinical seizure development at the homotopic contralateral site.
Wada
J A
JA
Division of Neurosciences, University of British Columbia, Vancouver, Canada.
Tsuchimochi
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D000679:Amygdala / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000502:physiology; D004558:Electric Stimulation; D004569:Electroencephalography; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D006179:Gyrus Cinguli / Q000502:physiology*; D006801:Humans; D007696:Kindling, Neurologic / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D009434:Neural Pathways / Q000502:physiology; D010215:Papio / Q000502:physiology*; D012640:Seizures / Q000209:etiology