Synergistic interaction between ORM1 and C3 types in disease associations.
In previous studies of orosomucoid (ORM) types and disease the ORM1 1 type has been found to be associated with sarcoidosis and other immunogenetic diseases, and the ORM 1 2 type with different types of carcinomas. We report significant associations between ORM1 and C3 types in sarcoidosis and breast cancer, but not in healthy individuals. The ORM1 1 and C3S variants in combination increased the risk of sarcoidosis, and the ORM1 2 and C3F variants together gave an increased risk of breast cancer. A probable mechanism may be that the ORM1 and C3 molecules modify the immune response by interacting with the lymphoid cell surface.
Fan
C
C
Department of Medical Genetics, Umeå University, Sweden.
Nylander
P O
PO
Stendahl
U
U
Thunell
M
M
Beckman
L
L
D000483:Alleles; D001943:Breast Neoplasms / Q000235:genetics* / Q000276:immunology; D003176:Complement C3 / Q000737:chemistry* / Q000235:genetics; D006801:Humans; D007166:Immunosuppressive Agents / Q000097:blood / Q000737:chemistry; D009961:Orosomucoid / Q000737:chemistry* / Q000235:genetics; D011110:Polymorphism, Genetic; D012507:Sarcoidosis / Q000235:genetics* / Q000276:immunology
D003176:Complement C3; D007166:Immunosuppressive Agents; D009961:Orosomucoid