title: Control of gastric acid with high dose H2-receptor antagonists after omeprazole failure: report of two cases.
abstract: Successful omeprazole therapy in patients with symptomatic gastroesophageal reflux (GER) refractory to treatment with H2-receptor antagonists has often been reported. In contrast, successful treatment of GER by H2-receptor antagonists in patients resistant to the acid-suppressing effects of omeprazole is rarely reported. We describe two patients who demonstrated therapeutic responses to high dose H2-receptor antagonists after high dose omeprazole failed to suppress gastric acidity and GER.
authors.affiliation: Department of Medicine, Graduate Hospital, Philadelphia, Pennsylvania, USA.
authors.forename: L P
authors.initials: LP
authors.lastname: Leite
authors.forename: R J
authors.initials: RJ
authors.lastname: Just
authors.forename: D O
authors.initials: DO
authors.lastname: Castell
authors.forename: P O
authors.initials: PO
authors.lastname: Lagerström
mesh_terms: D000328:Adult; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002927:Cimetidine / Q000627:therapeutic use; D004351:Drug Resistance; D005260:Female; D005744:Gastric Acid / Q000378:metabolism*; D005764:Gastroesophageal Reflux / Q000188:drug therapy* / Q000503:physiopathology; D006635:Histamine H2 Antagonists / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D016567:Nizatidine / Q000627:therapeutic use; D009853:Omeprazole / Q000627:therapeutic use*
chemical_list: D000897:Anti-Ulcer Agents; D006635:Histamine H2 Antagonists; D002927:Cimetidine; D009853:Omeprazole; D016567:Nizatidine