title: Longitudinal melanonychia induced by hydroxyurea: four case reports and review of the literature.
abstract: Although the occurrence of skin lesions during long-term hydroxyurea therapy is well known, longitudinal melanonychia (LM) are more rarely described. In the present paper, we report four cases of LM associated with skin lesions induced by long-term daily hydroxyurea therapy (4 to 10 years), characterized by two uncommon aspects: late onset (2.5 to 5 years) and predominance of toenail involvement in three cases.
authors.affiliation: Service d'Hématologie, Hôpital Louis Mourier, Colombes, France.
authors.forename: B
authors.initials: B
authors.lastname: Delmas-Marsalet
authors.forename: P
authors.initials: P
authors.lastname: Beaulieu
authors.forename: F
authors.initials: F
authors.lastname: Teillet-Thiebaud
authors.forename: L
authors.initials: L
authors.lastname: Jary
authors.forename: F
authors.initials: F
authors.lastname: Teillet
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D008543:Melanins / Q000096:biosynthesis*; D008875:Middle Aged; D009260:Nail Diseases / Q000139:chemically induced* / Q000378:metabolism; D010859:Pigmentation Disorders / Q000139:chemically induced* / Q000378:metabolism
chemical_list: D008543:Melanins; D006918:Hydroxyurea