[A study on effect of qingwen granule in regulating immunological function in infantile respiratory viral infection].
To evaluate the effect of Qing-wen Granule (QWG) on immunological function, T lymphocyte subsets and interferon gamma(INF-gamma) expression cells in peripheral blood mononuclear cells, lymphocyte transformation rate and the level of salivary secretory IgA (sIgA) were determined by alkaline phosphatase antialkaline phosphatase (APAAP) technique or 3H-TdR incorporation with lymphocyte stimulation index(SI) or agar single immunodiffusion in infantile respiratory viral infection. The results showed that the percentage of CD3, CD4, and CD4/CD8 ratio of patients treated with QWG for 3 days were not significantly different in comparing with the control group untreated with QWG (P > 0.05), but the values of IFN-gamma expression cell, SI and the level of sIgA were more markedly increased than that of control (P < 0.05). It suggested that the QWG could improve and regulate immune function in infantile respiratory viral infection.
Zhang
G C
GC
Dept. of Pediatrics, Xijing Hospital, Fouth Military Medical University, Xi'an.
Li
Z H
ZH
Shen
Q
Q
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D016516:CD4-CD8 Ratio; D002675:Child, Preschool; D004365:Drugs, Chinese Herbal / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007071:Immunoglobulin A, Secretory / Q000097:blood; D007223:Infant; D007371:Interferon-gamma / Q000097:blood; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D011024:Pneumonia, Viral / Q000188:drug therapy / Q000276:immunology; D012141:Respiratory Tract Infections / Q000188:drug therapy / Q000276:immunology* / Q000821:virology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014777:Virus Diseases / Q000188:drug therapy / Q000276:immunology*
D000276:Adjuvants, Immunologic; D004365:Drugs, Chinese Herbal; D007071:Immunoglobulin A, Secretory; D007371:Interferon-gamma