title: Reduced hippocampal CA1 Ca(2+)-induced long-term potentiation is associated with age-dependent impairment of spatial learning.
abstract: Expression of Ca(2+)-induced CA1 long-term potentiation (LTP) was analysed in hippocampal slices obtained from (1) 3-month-old and (2) 18-20-month-old Sprague-Dawley rats selected for their performances in the Morris water maze task. In all slices, a transient (10 min) increase of extracellular Ca2+ concentration (4 mM) caused a long-lasting enhancement of potentials evoked by electrical stimulation of radiatum fibers. However, a significant difference was found in the degree of potentiation among groups. In particular, increases of the CA1 response amplitudes were significantly lower in old rats impaired in spatial learning than in young at 30 (P < 0.05), 60, 90 and 120 min (P < 0.01) after restoring the normal Ca2+ concentration. On the contrary, no differences were observed between young animals and the old ones with good performances in spatial learning. The data suggest that amplitude of CA1 Ca(2+)-induced LTP in old rats is related to spatial learning abilities.
authors.affiliation: Laboratorio di Farmacologia, Istituto Superiore di Sanita, Roma, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Diana
authors.forename: M R
authors.initials: MR
authors.lastname: Domenici
authors.forename: A
authors.initials: A
authors.lastname: Scotti de Carolis
authors.forename: A
authors.initials: A
authors.lastname: Loizzo
authors.forename: S
authors.initials: S
authors.lastname: Sagratella
mesh_terms: D000375:Aging / Q000523:psychology*; D000818:Animals; D002118:Calcium / Q000494:pharmacology*; D004558:Electric Stimulation; D006624:Hippocampus / Q000187:drug effects*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000187:drug effects*; D018782:Maze Learning / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D002118:Calcium