Motor speech centres in the frontal cortex.
Activities of the frontal cortices in both cerebral hemispheres preceding utterance of a short word were recorded and analyzed with multichannel SQUID gradiometers. Light stimuli of two different colours of 500 ms duration were delivered in front of a subject at random time intervals and in irregular order of the different colours. The subject should respond to either of the stimuli by uttering a short word, e.g., 'en' [en] ('round' in Japanese) or another by a short simple voice without meaning as a word, e.g., 'e' [e]. The initial sounds of both voices are to be the same, i.e., 'e' [e] in these examples. The 37 gradiometers covering either the left or the right frontal-parietal part of the hemisphere recorded different magnetic fields between the word and the simple voice. Magnetic fields averaged 100 times at the onset of the stimuli revealed that the utterance of a word is preceded by significant magnetic field changes at a peak latency of 120-165 ms from the onset of light stimuli, whereas the utterance of a simple voice is not preceded by such changes. At a peak latency of 160-190 ms, about 20-40 ms before the start of perioral EMGs, both the utterances are commonly preceded by magnetic field changes. Dipole fittings based on these magnetic fields suggest that the earlier magnetic fields reflect electrical activities in the ventral lateral part of the frontal association area, usually in both left and right hemispheres, and that the later fields represent those in the sensorimotor area in both the hemispheres. That part of the frontal association area appears to be the centre for organizing words to speak and to correspond possibly to the Broca's speech area.
Sasaki
K
K
Department of Integrative Physiology, National Institute for Physiological Sciences, Okazaki, Japan.
Kyuhou
S
S
Nambu
A
A
Matsuzaki
R
R
Tsujimoto
T
T
Gemba
H
H
D000328:Adult; D004292:Dominance, Cerebral / Q000502:physiology; D005260:Female; D005625:Frontal Lobe / Q000502:physiology*; D007839:Functional Laterality / Q000502:physiology; D006801:Humans; D015225:Magnetoencephalography; D008297:Male; D008875:Middle Aged; D009046:Motor Neurons / Q000502:physiology*; D013060:Speech / Q000502:physiology*