[Immunopotentiation by OK-432 ointment to apply to the mouse abdominal skin].
The immunopotentiating effect of a streptococcal preparation, OK-432 (Picibanil), mixed with an ointment based Lanolin, was examined. The mixture was applied to mouse abdomen. The effect of OK-432 ointment was compared with those of OK-432 ip and sc. The leucocyte count in the abdominal cavity increased in 3.6 x 10(6) and 12.5 x 10(6) on the 3rd day after ointment application and ip injection of 5 KE OK-432, respectively. The result indicated that OK-432-Lanolin applied to the abdominal skin wall affected the abdominal cavity. IL-6 and IFN-gamma in the abdominal cavity increased in 1.4 ng and 9 ng, respectively, after applying 5 KE OK-432 ointment. From these results the treatment with OK-432 ointment on the abdominal skin exhibited an immunomodulatory effect on the abdominal cavity.
Matsuoka
H
H
Clinical Research Institute, National Kyushu Cancer Center.
Yano
K
K
Baba
H
H
Kounoe
S
S
Seo
Y
Y
Saito
T
T
Tomoda
H
H
Wakasugi
H
H
D000005:Abdomen; D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D004338:Drug Combinations; D015850:Interleukin-6 / Q000097:blood; D007809:Lanolin / Q000008:administration & dosage; D007958:Leukocyte Count; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009823:Ointment Bases / Q000008:administration & dosage; D009824:Ointments; D010844:Picibanil / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000494:pharmacology*; D012867:Skin / Q000276:immunology* / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
D000276:Adjuvants, Immunologic; D004338:Drug Combinations; D015850:Interleukin-6; D009823:Ointment Bases; D009824:Ointments; D014409:Tumor Necrosis Factor-alpha; D010844:Picibanil; D007809:Lanolin