title: Designing DNA-binding proteins on the surface of filamentous phage.
abstract: The strategy of molecular evolution by phage display recently has been applied to the study of interactions between protein and DNA. This technology will imminently enable DNA-binding proteins to be made to measure. In the first instance, this will greatly advance our understanding of protein-DNA interactions, but in the long term, it is expected to yield powerful tools for use in medicine and research.
authors.affiliation: Medical Research Council, Cambridge, UK.
authors.forename: Y
authors.initials: Y
authors.lastname: Choo
authors.forename: A
authors.initials: A
authors.lastname: Klug
mesh_terms: D000818:Animals; D001435:Bacteriophages; D004247:DNA / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D015202:Protein Engineering / Q000379:methods*; D011993:Recombinant Fusion Proteins / Q000737:chemistry / Q000378:metabolism; D016335:Zinc Fingers
chemical_list: D004268:DNA-Binding Proteins; D011993:Recombinant Fusion Proteins; D004247:DNA