title: A double-blind, randomized, placebo-controlled trial of cisapride in Saudi Arabs with functional dyspepsia.
abstract: BACKGROUND
  Trials on functional dyspepsia (FD) have been performed mostly in Western populations. We evaluated the effect of cisapride in Saudi Arabs with FD.
  
  
  METHODS
  In a double-blind, randomized, placebo-controlled trial patients were treated with cisapride three times daily or matching placebo and assessed at 2 and 4 weeks.
  
  
  RESULTS
  Cisapride (n = 44) was significantly superior to placebo (n = 45) in improving heartburn, postprandial bloating, epigastric pain, early satiety, epigastric burning, and nausea. The global response to treatment was excellent or good in 86.7% and 26.7% of the cisapride and placebo groups, respectively. Treatment was judged more effective than the previous therapy in 86.4% and 33.3% of those receiving cisapride and placebo, respectively. There were no adverse drug effects.
  
  
  CONCLUSIONS
  Cisapride is an effective and well-tolerated treatment for FD in Saudi Arabs. Pharmacogenetic factors are unlikely to play any role in its effects.
authors.affiliation: Dept of Internal Medicine, College of Medicine & Medical Sciences, King Faisal University, Al-Khobar, Saudi Arabia.
authors.forename: A
authors.initials: A
authors.lastname: al-Quorain
authors.forename: E B
authors.initials: EB
authors.lastname: Larbi
authors.forename: F
authors.initials: F
authors.lastname: al-Shedoki
mesh_terms: D000328:Adult; D000368:Aged; D000897:Anti-Ulcer Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D020117:Cisapride; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D004415:Dyspepsia / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000008:administration & dosage / Q000627:therapeutic use*; D012529:Saudi Arabia; D016896:Treatment Outcome
chemical_list: D000897:Anti-Ulcer Agents; D010880:Piperidines; D020117:Cisapride