title: Granulomatous reaction to Bowman's layer in herpetic keratitis and band keratopathy.
abstract: OBJECTIVE
  To characterize granulomatous reactions around Bowman's layer.
  
  
  METHODS
  Case series.
  
  
  METHODS
  Registry of Ophthalmic Pathology, Armed Forces Institute of Pathology, Washington.
  
  
  METHODS
  All patients with a code for granulomatous reactions to Bowman's (membrane) layer or Descemet's membrane. In addition, all corneas identified as having elastotic or calcific degeneration of Bowman's layer were reexamined to identify a possible granulomatous reaction to Bowman's layer.
  
  
  RESULTS
  Review of 210 corneal buttons and enucleated eyes yielded eight cases in which evidence of a granulomatous reaction to Bowman's layer was present: five patients with chronic keratitis, including three with herpetic keratitis (disciform in two and ulcerative in one), and three patients whose corneas had old degenerative pannus with calcification of Bowman's layer. In the patients with chronic keratitis the reaction tended to be focal and accompanied by inflammation; in those with degenerative pannus the reaction was diffuse and accompanied by minimal inflammation.
  
  
  CONCLUSIONS
  Granulomatous reactions to Bowman's layer are observed much less frequently than granulomatous reactions to Descemet's membrane. Although the pathogenesis of granulomatous reaction to Bowman's layer is unclear, a change in the antigenic properties of Bowman's layer may be implicated.
authors.affiliation: Department of Ophthalmology, New Jersey Medical School, Newark 07103-2499, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Mauriello
authors.forename: I W
authors.initials: IW
authors.lastname: McLean
authors.forename: P J
authors.initials: PJ
authors.lastname: Riddle
mesh_terms: D000328:Adult; D000368:Aged; D001485:Basement Membrane / Q000473:pathology; D002648:Child; D003315:Cornea / Q000473:pathology*; D003316:Corneal Diseases / Q000473:pathology*; D003320:Corneal Ulcer / Q000473:pathology*; D005260:Female; D006099:Granuloma / Q000473:pathology*; D006801:Humans; D016849:Keratitis, Herpetic / Q000473:pathology*; D008297:Male; D008875:Middle Aged