[Sclerosing cholangitis-induced biliary cyst formation: complication of hepatic artery infusion chemotherapy].
A 60-year-old man underwent resection of a sigmoid colon adenocarcinoma, left hepatic lobe, part of segment 6 and 8, due to its metastasis. He received hepatic artery infusions of 5-FU total amount, 15.5 g. There was no recurrence in the liver, but he developed sclerosing cholangitis, and a large biliary cyst formed in segment 8. After drainage of the cyst by percutaneous-trans-hepatic approach, bile leakage persisted, and liver dysfunction was progressive. Sclerosing cholangitis-induced biliary cyst formation is rare. Occlusion, or necrosis of the peripheral bile duct may be the cause.
Miyamoto
S
S
Dept. of Surgery, Tokyo Metropolitan Bokutou Hospital.
Umekita
N
N
Maeshiro
T
T
Awane
Y
Y
D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary; D001660:Biliary Tract Diseases / Q000209:etiology*; D015209:Cholangitis, Sclerosing / Q000209:etiology*; D003560:Cysts / Q000209:etiology*; D005472:Fluorouracil / Q000009:adverse effects; D006499:Hepatic Artery; D006801:Humans; D015918:Infusion Pumps, Implantable / Q000009:adverse effects*; D007261:Infusions, Intra-Arterial / Q000009:adverse effects*; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D008875:Middle Aged; D012811:Sigmoid Neoplasms / Q000473:pathology
D005472:Fluorouracil