Effect of pindolol on the prolactin response to d-fenfluramine.
We studied the effect of the 5-HT1A receptor antagonist, pindolol, on the prolactin (PRL) response to the 5-HT releasing agent, d-fenfluramine (d-FEN), in ten healthy male volunteers. Pindolol pretreatment lowered baseline PRL levels but, when this effect was taken into account, did not significantly attenuate the PRL response to d-FEN. Within the limitations that attend the use of pindolol as a 5-HT1A receptor antagonist, the data suggest that although 5-HT1A receptors may play a role in the tonic release of PRL, they are not involved in the release of PRL produced by d-FEN. We propose that the PRL response to d-FEN may involve selective activation of postsynaptic 5-HT2 receptors.
Park
S B
SB
University Department of Psychiatry, Littlemore Hospital, Oxford, UK.
Cowen
P J
PJ
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D005277:Fenfluramine / Q000494:pharmacology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010869:Pindolol / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood*; D011985:Receptors, Serotonin / Q000187:drug effects*; D012702:Serotonin Antagonists / Q000494:pharmacology*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists; D005277:Fenfluramine; D011388:Prolactin; D010869:Pindolol