Effect of nifedipine on the renal functional reserve in cyclosporine-treated renal-transplant recipients.
Cyclosporine decreases renal perfusion and impairs the renal hemodynamic response to a protein load. High-dose nifedipine has been shown to elevate renal plasma flow (RPF). We measured the renal functional reserve of 6 cyclosporine-treated renal-transplant recipients following intravenous administration of an amino acid solution, before and 2 weeks after therapy with high-dose nifedipine (up to 120 mg/day). Pretreatment renal functional reserve was nil Following administration of nifedipine, RPF increased by 22% (p < 0.01), filtration fraction decreased by 14% (p < 0.005) and renal vascular resistance declined by 39% (p < 0.005). Renal functional reserve remained unchanged. High-dose nifedipine increases renal perfusion but does not restore renal functional reserve in cyclosporine-treated renal-transplant recipients.
Chagnac
A
A
Department of Nephrology, Hasharon Hospital, Petah-Tikva, Israel.
Zevin
D
D
Weinstein
T
T
Korzets
A
A
Gafter
U
U
Hirsh
J
J
Levi
J
J
D000328:Adult; D000596:Amino Acids / Q000097:blood / Q000652:urine; D016572:Cyclosporine / Q000008:administration & dosage*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage*; D007668:Kidney / Q000187:drug effects* / Q000503:physiopathology; D007677:Kidney Function Tests; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000494:pharmacology*; D012079:Renal Circulation / Q000187:drug effects; D014665:Vasodilator Agents / Q000494:pharmacology*
D000596:Amino Acids; D007166:Immunosuppressive Agents; D014665:Vasodilator Agents; D016572:Cyclosporine; D009543:Nifedipine