[Acute promyelocytic leukemia following ulcerative colitis].
We report a case of acute promyelocytic leukemia (APL) following ulcerative colitis (UC). A 23-year-old man was diagnosed as UC in January 1991 and had been treated with salazosulfapyridine and prednisolone with good effect. In September 1993, he developed bleeding tendency and a diagnosis of APL with disseminated intravascular coagulation was made based on the results of bone marrow aspiration and coagulation profile. Complete remission was achieved with All-trans retinoic acid together with combined chemotherapy. He died of sepsis during consolidation chemotherapy in December 1993. Autopsy revealed no recurrence of UC.
Suzuki
Y
Y
Department of Internal Medicine, Yamada Red Cross Hospital.
Nakase
K
K
Nagaya
S
S
Tamaki
S
S
Tanigawa
M
M
Ikeda
T
T
Tsuji
K
K
Miyanishi
E
E
D000328:Adult; D000925:Anticoagulants / Q000008:administration & dosage; D003093:Colitis, Ulcerative / Q000150:complications* / Q000188:drug therapy; D004211:Disseminated Intravascular Coagulation / Q000188:drug therapy / Q000209:etiology; D017809:Fatal Outcome; D005765:Gastrointestinal Agents / Q000008:administration & dosage; D006493:Heparin / Q000008:administration & dosage; D006801:Humans; D007641:Keratolytic Agents / Q000008:administration & dosage; D015473:Leukemia, Promyelocytic, Acute / Q000188:drug therapy / Q000209:etiology*; D008297:Male; D012460:Sulfasalazine / Q000008:administration & dosage; D014212:Tretinoin / Q000008:administration & dosage
D000925:Anticoagulants; D005765:Gastrointestinal Agents; D007641:Keratolytic Agents; D012460:Sulfasalazine; D014212:Tretinoin; D006493:Heparin