title: [Cytotoxicity of aspidospermane indole alkaloids with a modified tryptamine chain].
abstract: Eight synthetic indole alkaloids with the aspidospermane structure have ben evaluated for cytotoxicity in the L-1210 cell culture test system. Two of them (compounds 9 and 5), bearing a modified tryptamine chain, were significantly active (IC50 values of 0.7 and 3.1 microM, respectively).
authors.affiliation: Laboratoire de Pharmacognosie, Faculté de Pharmacie, Caen, France.
authors.forename: G
authors.initials: G
authors.lastname: Lewin
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000494:pharmacology; D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000737:chemistry* / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D007939:Leukemia L1210 / Q000188:drug therapy; D051379:Mice; D010084:Oxidation-Reduction; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000470:Alkaloids; D000972:Antineoplastic Agents, Phytogenic
vernacular_title: Cytotoxicite d'alcaloides indoliques aspidospermane a chaine tryptamine modifiee.