Transmembrane topology of the glutamate receptors. A tale of novel twists and turns.
The glutamate receptor subunits were first thought to cross the cell membrane four times in a manner analogous to the neuronal nicotinic acetylcholine, GABAA, and glycine receptors. This model led the field for nearly five years, although it was frequently in conflict with the data. Recently, comparisons with bacterial proteins, epitope tagging experiments, and the construction of chimeras has produced a new model of glutamate receptor topology that is novel and quite unlike any of the other receptors.
Hughes
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TE
Department of Ophthalmology and Visual Science, Yale University School of Medicine, New Haven, CT 06520-8061, USA.
D000818:Animals; D001426:Bacterial Proteins / Q000737:chemistry / Q000235:genetics; D006801:Humans; D007473:Ion Channels / Q000737:chemistry / Q000145:classification / Q000235:genetics; D005810:Multigene Family; D011487:Protein Conformation; D017470:Receptors, Glutamate / Q000737:chemistry* / Q000145:classification / Q000235:genetics; D015398:Signal Transduction
D001426:Bacterial Proteins; D007473:Ion Channels; D017470:Receptors, Glutamate