Sea urchins--a new model for PAF research in embryology.
This study reports on the effect of PAF on sperm motility, fertilization and early embryo development in the sea urchin Strongylocentrotus intermedius. PAF proved to be the amplifier of sperm motility and fertilizing capability at 10(-8)-10(-9) M and was toxic at higher concentrations. BN 52201 did not counteract the PAF action. The advantages of using sea urchins for PAF research in embryology are discussed.
Berdyshev
E V
EV
Institute of Marine Biology, Vladivostok, Russia.
Vaskovsky
V E
VE
Vaschenko
M A
MA
D000818:Animals; D004224:Diterpenes; D005306:Fertilization / Q000187:drug effects; D046934:Ginkgolides; D007783:Lactones / Q000494:pharmacology; D008297:Male; D008954:Models, Biological; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology* / Q000633:toxicity; D012617:Sea Urchins / Q000187:drug effects* / Q000196:embryology / Q000502:physiology; D013081:Sperm Motility / Q000187:drug effects
D004224:Diterpenes; D046934:Ginkgolides; D007783:Lactones; D010972:Platelet Activating Factor; C045856:ginkgolide B