Vitamin B-6 adequacy in neonatal nutrition: associations with preterm delivery, type of feeding, and vitamin B-6 supplementation.
Concerns about vitamin B-6 adequacy in neonatal nutrition relate to critical functions of the vitamin in development. Vitamin B-6 status was assessed in six groups of neonates: two groups each of breast-fed term and preterm infants whose mothers were supplemented with 2 or 27 mg pyridoxine-hydrochloride (PN-HCl); a subgroup of term infants (2-mg maternal group) supplemented with 0.4 mg PN-HCl/d; and a formula-fed preterm group. During the 28-d experimental period, weekly assessments showed lower concentrations of total vitamin B-6 and percentages of pyridoxal in milk from mothers of preterm infants than in milk from mothers of term infants, even when maternal PN-HCl supplementation was 27 mg/d. The vitamin B-6 concentration of milk and estimated intakes of the vitamin by breast-fed infants paralleled maternal supplements (ie, 2 and 27 mg). Plasma and erythrocyte measurements of infants correlated with their vitamin B-6 intakes; values were highest for infants given vitamin B-6 supplements and those that wee formula-fed. Vitamin B-6 adequacy was questionable for unsupplemented breast-fed infants of mothers in the 2-mg supplemented groups.
Kang-Yoon
S A
SA
Department of Foods and Nutrition, Purdue University, West Lafayette, IN 47907-1264, USA.
Kirksey
A
A
Giacoia
G P
GP
West
K D
KD
D000293:Adolescent; D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D001903:Bottle Feeding; D001942:Breast Feeding; D002657:Child Development / Q000502:physiology; D004435:Eating; D005260:Female; D005865:Gestational Age; D006801:Humans; D007225:Infant Food / Q000592:standards; D007227:Infant Nutritional Physiological Phenomena / Q000502:physiology*; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood / Q000502:physiology*; D008895:Milk, Human / Q000737:chemistry; D009751:Nutritional Requirements; D011732:Pyridoxal Phosphate / Q000097:blood; D011736:Pyridoxine / Q000008:administration & dosage* / Q000032:analysis
D011732:Pyridoxal Phosphate; D000410:Alanine Transaminase; D011736:Pyridoxine