title: Diversity among Leishmania isolates from the Sudan: isoenzyme homogeneity of L. donovani versus heterogeneity of L. major.
abstract: Leishmania isolates from patients in the Sudan suffering from either visceral or cutaneous leishmaniasis were characterized using a battery of 12 enzymes. Aspartate aminotransferase separated the L. donovani isolates into 2 distinct zymodemes, but the overall results showed no significant geographical variation among L. donovani isolates. In contrast, the isolates of L. major were polymorphic, exhibiting differences in nucleoside hydrolase, 6-phosphogluconate dehydrogenase, superoxide dismutase, esterase, mannose phosphate isomerase, and aspartate aminotransferase, resulting in the description of 4 new enzymatic variants.
authors.affiliation: Centre for Medical Parasitology, University of Copenhagen, Denmark.
authors.forename: M E
authors.initials: ME
authors.lastname: Ibrahim
authors.forename: D A
authors.initials: DA
authors.lastname: Evans
authors.forename: T G
authors.initials: TG
authors.lastname: Theander
authors.forename: A M
authors.initials: AM
authors.lastname: el Hassan
authors.forename: A
authors.initials: A
authors.lastname: Kharazmi
mesh_terms: D000818:Animals; D006801:Humans; D007527:Isoenzymes / Q000302:isolation & purification*; D007893:Leishmania donovani / Q000201:enzymology*; D018320:Leishmania major / Q000201:enzymology*; D016773:Leishmaniasis, Cutaneous / Q000201:enzymology / Q000469:parasitology*; D007898:Leishmaniasis, Visceral / Q000201:enzymology / Q000469:parasitology*; D013397:Sudan
chemical_list: D007527:Isoenzymes