title: Influence of two amounts of dietary casein on uric acid, sodium urate, and ammonium urate urinary activity product ratios of healthy beagles.
abstract: Casein has been used as a protein source in diets designed to dissolve canine ammonium urate uroliths and to prevent their recurrence, because it contains fewer purine precursors than do many other sources of protein. However, an important question is whether reduced quantities of dietary casein have any benefit in modifying saturation of urine with urates. To answer this question, activity product ratios of uric acid, sodium urate, and ammonium urate were determined in 24-hour urine samples produced by 6 healthy Beagles during periods of consumption of a 10.4% protein, casein-based (10.4% casein) diet and a 20.8% protein, casein-based (20.8%casein) diet. Significantly lower 24-hour urinary excretions of ammonia and phosphorus were observed when dogs consumed the 10.4% casein diet. These results suggest that use of the 10.4% casein diet in protocols designed for dissolution and prevention of uric acid, sodium urate, and ammonium urate uroliths in dogs may be beneficial.
authors.affiliation: Departments of Small Animal Clinical Sciences, College of Veterinary Medicine, University of Minnesota, St Paul 55108, USA.
authors.forename: J W
authors.initials: JW
authors.lastname: Bartges
authors.forename: C A
authors.initials: CA
authors.lastname: Osborne
authors.forename: L J
authors.initials: LJ
authors.lastname: Felice
authors.forename: C
authors.initials: C
authors.lastname: Brown
authors.forename: T A
authors.initials: TA
authors.lastname: Allen
authors.forename: L
authors.initials: L
authors.lastname: Koehler
authors.forename: L
authors.initials: L
authors.lastname: Unger
authors.forename: K
authors.initials: K
authors.lastname: Bird
authors.forename: M
authors.initials: M
authors.lastname: Chen
mesh_terms: D000641:Ammonia / Q000652:urine; D000818:Animals; D001663:Bilirubin / Q000097:blood; D001798:Blood Proteins / Q000378:metabolism; D002364:Caseins / Q000494:pharmacology*; D003404:Creatinine / Q000378:metabolism; D004044:Dietary Proteins; D004285:Dogs / Q000378:metabolism*; D004573:Electrolytes / Q000097:blood; D004798:Enzymes / Q000097:blood; D005260:Female; D006863:Hydrogen-Ion Concentration; D008055:Lipids / Q000097:blood; D012016:Reference Values; D012709:Serum Albumin / Q000378:metabolism; D014527:Uric Acid / Q000652:urine*
chemical_list: D001798:Blood Proteins; D002364:Caseins; D004044:Dietary Proteins; D004573:Electrolytes; D004798:Enzymes; D008055:Lipids; D012709:Serum Albumin; D014527:Uric Acid; D000641:Ammonia; D003404:Creatinine; D001663:Bilirubin