Thrombin active site inhibitors.
Development of small molecule thrombin active site inhibitors has been an area of intense research. A brief review on recent progress and challenges is outlined.
Das
J
J
Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.
Kimball
S D
SD
D000925:Anticoagulants / Q000737:chemistry* / Q000494:pharmacology; D000991:Antithrombins / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure; D012694:Serine; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000737:chemistry*
D000925:Anticoagulants; D000991:Antithrombins; D012694:Serine; D013917:Thrombin