title: Cytokines and plasminogen activator inhibitor-1 in posttrauma disseminated intravascular coagulation: relationship to multiple organ dysfunction syndrome.
abstract: OBJECTIVE
  a) To investigate the relationships between tumor necrosis factor-alpha (TNF-alpha), interleukin-1 beta (IL-1 beta), plasminogen activator inhibitor-1, and disseminated intravascular coagulation (DIC); b) to determine the influence of DIC on the mortality rate, adult respiratory distress syndrome (ARDS), and multiple organ dysfunction syndrome; and c) to find a useful prognostic index for outcome.
  
  
  METHODS
  Prospective, case-control study.
  
  
  METHODS
  General intensive care unit (tertiary care center) in a city hospital serving a population of 1.5 million people.
  
  
  METHODS
  Fifty-eight trauma patients; 22 of the patients with DIC and 36 of the patients without DIC.
  
  
  METHODS
  None.
  
  
  RESULTS
  TNF-alpha, IL-1 beta, plasminogen activator inhibitor-1 activity, and plasminogen activator inhibitor-1 antigen concentration were measured on the day of the injury, and on days 1, 3, and 5 after admission. The results of these measurements, demographic data, severity of illness score, mortality rate in the intensive care unit and frequencies of ARDS, multiple organ dysfunction syndrome, and sepsis were compared according to the occurrence of DIC. DIC patients were classified into subgroups of survivors and nonsurvivors, and the changes in plasminogen activator inhibitor-1 between subgroups were studied. The Acute Physiology and Chronic Health Evaluation II scores, the Injury Severity Scores, and the frequency of ARDS and multiple organ dysfunction syndrome were higher in the DIC patients. The mortality rate of the DIC patients was higher than the rate of the non-DIC patients (59.0% vs. 13.8%; p = .0009). TNF-alpha and IL-1 beta concentrations increased more in the DIC patients than in the non-DIC patients. Plasminogen activator inhibitor-1 activity and plasminogen activator inhibitor-1 antigen concentrations in the DIC patients, especially those values in the nonsurvivors, continued to be markedly high up to day 5 of admission. The most favorable prognostic value of plasminogen activator inhibitor-1 for the prediction of death in all of the trauma patients and the DIC patients was determined on days 3 and 5, respectively. No significant correlation was noted between the two cytokines and plasminogen activator inhibitor-1.
  
  
  CONCLUSIONS
  In the patients with trauma, DIC is a predictor of ARDS, multiple organ dysfunction syndrome, and death. TNF-alpha and IL-1 beta might be one of the causes of DIC, while plasminogen activator inhibitor-1 may be one of the aggravating factors of ARDS and multiple organ dysfunction syndrome. Plasminogen activator inhibitor-1 is a good predictor of death for posttrauma DIC patients.
authors.affiliation: Department of Emergency and Critical Care Medicine, Sapporo City General Hospital, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Gando
authors.forename: Y
authors.initials: Y
authors.lastname: Nakanishi
authors.forename: I
authors.initials: I
authors.lastname: Tedo
mesh_terms: D018806:APACHE; D000328:Adult; D016022:Case-Control Studies; D004211:Disseminated Intravascular Coagulation / Q000097:blood* / Q000150:complications* / Q000401:mortality; D005260:Female; D006801:Humans; D007362:Intensive Care Units; D007375:Interleukin-1 / Q000097:blood*; D008297:Male; D009102:Multiple Organ Failure / Q000097:blood* / Q000209:etiology; D017395:Plasminogen Activator Inhibitor 1 / Q000097:blood*; D011237:Predictive Value of Tests; D011379:Prognosis; D011446:Prospective Studies; D012128:Respiratory Distress Syndrome / Q000097:blood / Q000175:diagnosis / Q000209:etiology; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*; D014947:Wounds and Injuries / Q000097:blood* / Q000150:complications* / Q000401:mortality
chemical_list: D007375:Interleukin-1; D017395:Plasminogen Activator Inhibitor 1; D014409:Tumor Necrosis Factor-alpha