Sinugibberol, a new cytotoxic cembranoid diterpene from the soft coral Sinularia gibberosa.
Bioactivity-guided fractionation of a chloroform extract of the soft coral Simularia gibberosa afforded a new cytotoxic cembranoid diterpene, sinugibberol [1]. The structure of 1 was determined by spectral and X-ray crystallographic analysis.
Hou
R S
RS
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, Republic of China.
Duh
C Y
CY
Chiang
M Y
MY
Lin
C N
CN
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology*; D003063:Cnidaria / Q000737:chemistry*; D018360:Crystallography, X-Ray; D004224:Diterpenes / Q000737:chemistry / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005583:Fourier Analysis; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D051379:Mice; D013778:Tetrazolium Salts; D013844:Thiazoles; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes; D013778:Tetrazolium Salts; D013844:Thiazoles; C095790:sinugibberol; C022616:thiazolyl blue