title: Diastolic dysfunction is not related to changes in glycaemic control over 6 months in type 2 (non-insulin-dependent) diabetes mellitus. A cross-sectional study.
abstract: Diastolic dysfunction may be the earliest marker of a diabetes-induced heart muscle disease which leads to the progressive development of cardiac failure. Left ventricular diastolic function was indirectly assessed using pulsed wave Doppler ultrasound mitral-flow velocities in 20 normotensive patients with a new diagnosis of type 2 diabetes mellitus, normal cardiac function and no evidence of coronary artery disease and in 16 age-matched normal subjects. Peak velocities of early (E) and late (A) left ventricular filling were measured. The median (interquartile ranges) peak E/A ratio was significantly reduced in the diabetic group 0.96 (0.8-1.2) vs 1.2 (1.1-1.3), P < 0.01. Despite improvements in glycaemic control over 3 months, HbA1c 9.9% (7.6%-10.5%) to 7.4% (6.5%-7.9%), P < 0.001, maintained at 6 months, HbA1c 7.0% (6.4%-7.3%), there were no changes in the E/A ratio, 0.96 (0.83-1.15) and 0.95 (0.83-1.17), respectively. Furthermore, there was no correlation between percentage change in HbA1c and E/A ratio over 6 months. The results of this study suggest that in patients with type 2 diabetes mellitus and normal systolic function, diastolic function was impaired at diagnosis and was not affected by an improvement in the glycaemic control.
authors.affiliation: Diabetes and Thrombosis Research Group, University of Leeds, UK.
authors.forename: S C
authors.initials: SC
authors.lastname: Gough
authors.forename: J
authors.initials: J
authors.lastname: Smyllie
authors.forename: M
authors.initials: M
authors.lastname: Barker
authors.forename: K E
authors.initials: KE
authors.lastname: Berkin
authors.forename: P J
authors.initials: PJ
authors.lastname: Rice
authors.forename: P J
authors.initials: PJ
authors.lastname: Grant
mesh_terms: D001786:Blood Glucose / Q000378:metabolism*; D002784:Cholesterol / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000503:physiopathology*; D003971:Diastole; D004562:Electrocardiography; D005340:Fibrinogen / Q000032:analysis; D005500:Follow-Up Studies; D015637:Gated Blood-Pool Imaging; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D008875:Middle Aged; D012016:Reference Values; D013599:Systole; D013997:Time Factors; D014280:Triglycerides / Q000097:blood; D016277:Ventricular Function, Left
chemical_list: D001786:Blood Glucose; D002784:Cholesterol; D005340:Fibrinogen; D006442:Glycated Hemoglobin; D014280:Triglycerides