Gut-derived mediators of multiple organ failure: platelet-activating factor and interleukin-6.
Laboratory studies suggest that the postischaemic gut serves as a priming bed for circulating neutrophils that provoke multiple organ failure. Platelet-activating factor, generated by phospholipase A2, appears to be active in priming neutrophils in the gut. Interleukin-6 also appears to be elaborated by the postischaemic gut, but may be even more important in distant organs via promoting neutrophil-mediated organ dysfunction.
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Department of Surgery, Denver General Hospital, University of Colorado Health Sciences Centre, Colorado 80204, USA.
Moore
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Moore
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D000818:Animals; D004195:Disease Models, Animal; D006801:Humans; D007249:Inflammation; D015850:Interleukin-6 / Q000502:physiology*; D009102:Multiple Organ Failure / Q000097:blood / Q000276:immunology* / Q000503:physiopathology*; D009504:Neutrophils / Q000276:immunology; D010972:Platelet Activating Factor / Q000502:physiology*; D051381:Rats; D013152:Splanchnic Circulation
D015850:Interleukin-6; D010972:Platelet Activating Factor