title: Protein sorting signals: simple peptides with complex functions.
abstract: Protein sorting signals provide good examples of peptides that can be studied both from a chemical and a biochemical perspective. Their simple designs and low degree of sequence conservation suggest that they are involved in rather non-specific peptide-lipid interactions, yet their ability to discriminate efficiently between the import machineries of different subcellular compartments rather points to the importance of peptide-receptor interactions. The study of protein sorting signals thus invites a cross-disciplinary approach.
authors.affiliation: Department of Biochemistry, Arrhenius Laboratories for Natural Sciences, Stockholm University, Sweden.
authors.forename: G
authors.initials: G
authors.lastname: von Heijne
mesh_terms: D002462:Cell Membrane / Q000737:chemistry / Q000378:metabolism; D002736:Chloroplasts / Q000378:metabolism; D004926:Escherichia coli / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism; D008565:Membrane Proteins / Q000737:chemistry / Q000378:metabolism; D008928:Mitochondria / Q000378:metabolism; D021382:Protein Sorting Signals / Q000737:chemistry* / Q000235:genetics; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry / Q000378:metabolism*
chemical_list: D008565:Membrane Proteins; D021382:Protein Sorting Signals; D011506:Proteins