title: Thrombin active site inhibitors.
abstract: Development of small molecule thrombin active site inhibitors has been an area of intense research. A brief review on recent progress and challenges is outlined.
authors.affiliation: Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, NJ 08543-4000, USA.
authors.forename: J
authors.initials: J
authors.lastname: Das
authors.forename: S D
authors.initials: SD
authors.lastname: Kimball
mesh_terms: D000925:Anticoagulants / Q000737:chemistry* / Q000494:pharmacology; D000991:Antithrombins / Q000737:chemistry* / Q000494:pharmacology; D001665:Binding Sites; D015195:Drug Design; D006801:Humans; D015394:Molecular Structure; D012694:Serine; D013329:Structure-Activity Relationship; D013917:Thrombin / Q000037:antagonists & inhibitors* / Q000737:chemistry*
chemical_list: D000925:Anticoagulants; D000991:Antithrombins; D012694:Serine; D013917:Thrombin