title: Acquired haemophilia--a therapeutic challenge.
abstract: Acquired haemophilia is a rare clinical condition arising from the spontaneous development of inhibitors to factor VIII. We describe two cases encountered in the University Hospital over the past five years. We also review the literature and discuss the therapeutic difficulties faced in dealing with patients with high levels of inhibitors. In one of these patients we also describe, for the first time in this region, a novel method in managing the acute bleeding episode in acquired haemophilia using recombinant factor VIIa.
authors.affiliation: Department of Medicine, University Hospital, Kuala Lumpur.
authors.forename: A
authors.initials: A
authors.lastname: Teh
authors.forename: K W
authors.initials: KW
authors.lastname: Leong
authors.forename: J J
authors.initials: JJ
authors.lastname: Bosco
authors.forename: P L
authors.initials: PL
authors.lastname: Koong
authors.forename: S
authors.initials: S
authors.lastname: Jayaranee
mesh_terms: D000328:Adult; D000906:Antibodies / Q000276:immunology; D000917:Antibody Formation; D005169:Factor VIII / Q000276:immunology; D015942:Factor VIIa / Q000627:therapeutic use; D005260:Female; D006467:Hemophilia A / Q000209:etiology* / Q000276:immunology / Q000628:therapy*; D006801:Humans; D011994:Recombinant Proteins
chemical_list: D000906:Antibodies; D011994:Recombinant Proteins; D005169:Factor VIII; D015942:Factor VIIa