Cerebral magnetic resonance imaging compared in Alzheimer's and multi-infarct dementia.
Cerebral magnetic resonance images (MRI) were compared between two groups, each of 25 patients, one with senile dementia of the Alzheimer's type (SDAT) and the other with multi-infarct dementia (MID). MRI proved to be clinically useful for differentiating SDAT from MID, utilizing a multivariate model of six MRI criteria as follows: ventricular-brain ratio, presence of subcortical infarcts, bifrontal ventricular ratio, bicaudate ventricular ratio, third ventricular ratio, and presence of diffuse periventricular high-intensity white matter lucencies. Utilizing all six MRI criteria, classification by discriminant function analysis provided 84% correct diagnostic agreement with clinical classification of MID patients, 92% for SDAT patients, and 88% for the total cohort of demented patients.
Reed
K M
KM
Cerebral Blood Flow Laboratories, Veterans Administration Medical Center, Houston, TX 77211, USA.
Rogers
R L
RL
Meyer
J S
JS
D000368:Aged; D000544:Alzheimer Disease / Q000473:pathology*; D001921:Brain / Q000473:pathology*; D015161:Dementia, Multi-Infarct / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged