title: Follow up of an immunocompromised contact group of a case of open pulmonary tuberculosis on a renal unit.
abstract: BACKGROUND
  The organisation, management, outcome and cost of follow up of a large group of mainly immunocompromised patients and healthcare workers who were exposed to a staff member of a London renal unit with smear positive pulmonary tuberculosis are described.
  
  
  METHODS
  Following British Thoracic Society (BTS) guidelines, 576 close contacts were identified and divided into three groups: (1) 303 renal patients including 61 with renal transplants; (2) 90 surgical patients; and (3) 183 staff members. Screened contacts were interviewed, completed a symptoms questionnaire, and were offered a chest radiograph and Heaf or Mantoux test if appropriate with referral to a chest physician if required.
  
  
  RESULTS
  Overall, 524 (85%) living contacts have been screened: 243 (97%) renal (first screening), 63 (70%) surgical, and 135 (74%) staff contacts. Thirty one transplant patients were prescribed isoniazid chemoprophylaxis. Fifty two renal patients had died before screening and 11 deaths occurred after first interview. One case of tuberculosis epidemiologically related to the index case was diagnosed on clinical criteria. A review of the case records and/or death certificates and entries on to tuberculosis registers indicated no further cases. The cost of the investigation was estimated to be approximately franc25 000, or franc44 per contact screened, with staff costs comprising 79% of the total.
  
  
  CONCLUSIONS
  Undiagnosed tuberculosis in healthcare workers working with immunosuppressed patients can lead to large and expensive follow up studies. The applicability of the 1990 and 1994 BTS guidelines to the investigation of tuberculosis in an immunocompromised nosocomial group, and the role of the infection control doctor and the consultant in Communicable Disease Control in overlapping nosocomial and community incidents, are discussed.
authors.affiliation: Public Health Laboratory, Dulwich Hospital, London, UK.
authors.forename: F A
authors.initials: FA
authors.lastname: Drobniewski
authors.forename: J
authors.initials: J
authors.lastname: Ferguson
authors.forename: K
authors.initials: K
authors.lastname: Barritt
authors.forename: R M
authors.initials: RM
authors.lastname: Higgins
authors.forename: M
authors.initials: M
authors.lastname: Higgon
authors.forename: D
authors.initials: D
authors.lastname: Neave
authors.forename: A H
authors.initials: AH
authors.lastname: Uttley
authors.forename: D
authors.initials: D
authors.lastname: O'Sullivan
authors.forename: A
authors.initials: A
authors.lastname: Hay
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002985:Clinical Protocols; D003219:Confidentiality; D016358:Contact Tracing / Q000191:economics; D003365:Costs and Cost Analysis; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016867:Immunocompromised Host; D017757:Infectious Disease Transmission, Professional-to-Patient; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D014397:Tuberculosis, Pulmonary / Q000191:economics / Q000453:epidemiology / Q000635:transmission*