title: Polyphenolic flavanols as scavengers of aqueous phase radicals and as chain-breaking antioxidants.
abstract: The purpose of this investigation was to establish the relative antioxidant activities in vitro of the flavanolic polyphenols, the catechins, and catechin-gallate esters. The relative antioxidant potentials were measured against radicals generated in the aqueous phase and against propagating lipid peroxyl radicals. The results show that in the aqueous phase their order of effectiveness as radical scavengers is epicatechin gallate (ECG) > epigallocatechin gallate (EGCG) > epigallocatechin (EGC) > gallic acid (GA) > epicatechin congruent to catechin; against propagating lipid peroxyl radical species, epicatechin and catechin are as effective as ECG and EGCG, the least efficacious being EGC and GA. This is consistent with their relative abilities to protect against consumption of LDL alpha-tocopherol. The results are discussed in the context of the most relevant antioxidant constituents of green tea extracts.
authors.affiliation: Radical Research Group, UMDS--Guy's Hospital, University of London, United Kingdom.
authors.forename: N
authors.initials: N
authors.lastname: Salah
authors.forename: N J
authors.initials: NJ
authors.lastname: Miller
authors.forename: G
authors.initials: G
authors.lastname: Paganga
authors.forename: L
authors.initials: L
authors.lastname: Tijburg
authors.forename: G P
authors.initials: GP
authors.lastname: Bolwell
authors.forename: C
authors.initials: C
authors.lastname: Rice-Evans
mesh_terms: D000975:Antioxidants; D002392:Catechin / Q000737:chemistry* / Q000494:pharmacology; D004952:Esters / Q000737:chemistry; D005419:Flavonoids; D016166:Free Radical Scavengers; D005707:Gallic Acid / Q000737:chemistry* / Q000494:pharmacology; D008077:Lipoproteins, LDL / Q000737:chemistry; D008956:Models, Chemical; D010084:Oxidation-Reduction / Q000187:drug effects; D010636:Phenols / Q000737:chemistry* / Q000494:pharmacology; D011108:Polymers / Q000737:chemistry* / Q000494:pharmacology; D013662:Tea / Q000737:chemistry*; D014867:Water / Q000737:chemistry
chemical_list: D000975:Antioxidants; D004952:Esters; D005419:Flavonoids; D016166:Free Radical Scavengers; D008077:Lipoproteins, LDL; D010636:Phenols; D011108:Polymers; D013662:Tea; D014867:Water; D005707:Gallic Acid; D002392:Catechin