title: [Multiple colonic ulcers in a patient with Sjögren's syndrome].
abstract: A 25-year-old female with Sjögren's syndrome was admitted to our hospital because of fever and abdominal pain. Multiple colonic ulcers were demonstrated by gastrographin enema and colonoscopy. Histological examination revealed the presence of necrotizing vasculitis in the submucosal region. Large dose of prednisolone (60 mg/day) brought a prompt relief of her symptoms and an improvement of positive inflammatory signs. Pseudoaneurysm in the arteria colica media, which had been demonstrated by abdominal selective angiography at the time of diagnosis, became extinct after the steroid treatment. Healing of ulcers were also noted by colonoscopy. A variety of extraglandular symptoms has been reported in Sjögren's syndrome. Multiple colonic ulcers due to vasculitis are rarely complicated but may have a great impact on the prognosis of the disease.
authors.affiliation: First Department of Internal Medicine, Kagawa Medical School.
authors.forename: M
authors.initials: M
authors.lastname: Inoh
authors.forename: M
authors.initials: M
authors.lastname: Tokuda
authors.forename: T
authors.initials: T
authors.lastname: Maruoka
authors.forename: M
authors.initials: M
authors.lastname: Kinashi
authors.forename: N
authors.initials: N
authors.lastname: Kurata
authors.forename: M
authors.initials: M
authors.lastname: Okawa
authors.forename: J
authors.initials: J
authors.lastname: Takahara
mesh_terms: D000328:Adult; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage; D003108:Colonic Diseases / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D006801:Humans; D011239:Prednisolone / Q000008:administration & dosage; D012859:Sjogren's Syndrome / Q000150:complications*; D014456:Ulcer / Q000188:drug therapy / Q000209:etiology; D014657:Vasculitis / Q000150:complications
chemical_list: D000893:Anti-Inflammatory Agents; D011239:Prednisolone