title: Decrease in cerebellin and corticotropin-releasing hormone in the cerebellum of olivopontocerebellar atrophy and Shy-Drager syndrome.
abstract: Four neuropeptides; cerebellin, corticotropin-releasing hormone (CRH), neuropeptide Y and somatostatin were studied by radioimmunoassay in the postmortem human brains obtained from three patients with olivopontocerebellar atrophy (OPCA) and one with Shy-Drager syndrome. Significant decreases in cerebellin and CRH concentrations were found in the cerebellar hemisphere of these diseases compared with controls. These findings suggest important pathophysiological roles of cerebellin and CRH in these cerebellar diseases. Such significant decreases were not found in neuropeptide Y and somatostatin.
authors.affiliation: Department of Neurology, Tohoku University School of Medicine, Sendai, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Mizuno
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Totsune
authors.forename: M
authors.initials: M
authors.lastname: Ohneda
authors.forename: H
authors.initials: H
authors.lastname: Konno
authors.forename: O
authors.initials: O
authors.lastname: Murakami
authors.forename: F
authors.initials: F
authors.lastname: Satoh
authors.forename: M
authors.initials: M
authors.lastname: Sone
authors.forename: S
authors.initials: S
authors.lastname: Takase
authors.forename: Y
authors.initials: Y
authors.lastname: Itoyama
mesh_terms: D000328:Adult; D000368:Aged; D002531:Cerebellum / Q000378:metabolism*; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000378:metabolism*; D009478:Neuropeptide Y / Q000378:metabolism; D009849:Olivopontocerebellar Atrophies / Q000378:metabolism*; D011863:Radioimmunoassay; D012791:Shy-Drager Syndrome / Q000378:metabolism*; D013004:Somatostatin / Q000378:metabolism
chemical_list: D009419:Nerve Tissue Proteins; D009478:Neuropeptide Y; D013004:Somatostatin; D003346:Corticotropin-Releasing Hormone; C046788:cerebellin