title: An endogenous lectin and its glycoprotein ligands are triggering basal and axon-induced Schwann cell proliferation.
abstract: The proliferation of Schwann cells (the myelinating cells of the peripheral nervous system) is stimulated by the contact with axonal membranes. It is suggested that the endogenous carbohydrate-binding protein (lectin) cerebellar soluble lectin (CSL) bound to ligands at the surface of axonal preparations is mitogenic for Schwann cells. Both autocrine and axon-stimulated Schwann cell proliferations seem to be dependent on the presence of CSL and its ligands at the Schwann cell surface, as suggested by the effects of N-glycosylation inhibitors and anti-CSL Fab fragments. These data suggest that CSL regulates Schwann cell proliferation by clustering of a few glycoprotein ligands at the cell surface, consequently modulating phosphorylations.
authors.affiliation: Laboratoire de Neurobiologie Moléculaire des Interactions Cellulaires CNRS UPR 416, Centre de Neurochimie, Strasbourg, France.
authors.forename: A
authors.initials: A
authors.lastname: Badache
authors.forename: S
authors.initials: S
authors.lastname: Lehmann
authors.forename: S
authors.initials: S
authors.lastname: Kuchler-Bopp
authors.forename: N
authors.initials: N
authors.lastname: Hand
authors.forename: J P
authors.initials: JP
authors.lastname: Zanetta
mesh_terms: D017485:1-Deoxynojirimycin / Q000494:pharmacology; D000818:Animals; D001369:Axons / Q000502:physiology*; D002455:Cell Division / Q000187:drug effects / Q000502:physiology*; D002478:Cells, Cultured; D004791:Enzyme Inhibitors / Q000494:pharmacology; D006023:Glycoproteins / Q000032:analysis / Q000378:metabolism / Q000494:pharmacology*; D006031:Glycosylation; D037102:Lectins / Q000032:analysis / Q000494:pharmacology* / Q000502:physiology; D008934:Mitogens / Q000494:pharmacology*; D051381:Rats; D012583:Schwann Cells / Q000737:chemistry / Q000166:cytology*; D017026:Swainsonine / Q000494:pharmacology; D014415:Tunicamycin / Q000494:pharmacology
chemical_list: D004791:Enzyme Inhibitors; D006023:Glycoproteins; D037102:Lectins; D008934:Mitogens; C059525:cerebellar soluble lectin; D014415:Tunicamycin; D017485:1-Deoxynojirimycin; D017026:Swainsonine