Efficacy of 6-amino-2-n-pentylthiobenzothiazole on Trichophyton in vitro and in vivo.
In vitro and in vivo antifungal activities of synthetically parepared 6-amino-2-n-pentylthiobenzothiazole (APB) against Trichophyton strains were studied. APB inhibited the growth of 3 Trichophyton strains at 65 micrograms/ml. 2-Mercaptobenzothiazole was not effective at 125 micrograms/ml and ketoconazole inhibited the growth at 20-30 micrograms/ml. Treatment of experimental dermatophytosis in guinea pigs using 2.5% APB cream was studied in comparison to Canesten cream (1% clotrimazole). Dermatophytosis was considerably reduced after both APB and Canesten therapies.
Bujdáková
H
H
Department of Microbiology and Virology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovak Republic.
Múcková
M
M
Klobusický
M
M
Sidóová
E
E
D000818:Animals; D000935:Antifungal Agents / Q000494:pharmacology* / Q000627:therapeutic use*; D052160:Benzothiazoles; D003022:Clotrimazole / Q000627:therapeutic use; D006168:Guinea Pigs; D007654:Ketoconazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D013844:Thiazoles / Q000494:pharmacology* / Q000627:therapeutic use*; D014005:Tinea / Q000188:drug therapy*; D014249:Trichophyton / Q000187:drug effects*
D000935:Antifungal Agents; D052160:Benzothiazoles; D013844:Thiazoles; C005563:captax; C078412:6-amino-2-n-pentylthiobenzothiazole; D003022:Clotrimazole; D007654:Ketoconazole