Nitro-L-arginine augments the endothelin-1 content of cerebrospinal fluid induced by cerebral ischemia.
The effect of nitro-L-arginine (NLA), inhibitor of NO synthase, on ET-1 content in cerebrospinal fluid (CSF) and on the vascular system was investigated in global ischemia/reperfusion of Mongolian gerbils. The results indicate that NLA induced a prolonged (2-3-fold) increase of ET-1 concentration above that seen in the CSF of untreated animals during ischemia/reperfusion. Both the transient and prolonged rise of ET-1 content observed in the CSF coincided with the reduction in the cerebral blood flow seen in untreated and NLA-treated gerbils, respectively, at the time of reperfusion.
Spatz
M
M
National Institutes of Health, Stroke Branch, National Institute of Neurological Disorders and Stroke, Bethesda, MD 20892, USA.
Stanimirovic
D
D
Strasser
A
A
McCarron
R M
RM
D000818:Animals; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D002545:Brain Ischemia / Q000097:blood / Q000134:cerebrospinal fluid*; D002560:Cerebrovascular Circulation; D016232:Endothelins / Q000097:blood / Q000134:cerebrospinal fluid*; D004791:Enzyme Inhibitors / Q000494:pharmacology*; D005849:Gerbillinae; D019335:Nitroarginine; D009994:Osmolar Concentration; D015424:Reperfusion; D013997:Time Factors
D016232:Endothelins; D004791:Enzyme Inhibitors; D019335:Nitroarginine; D001120:Arginine