title: Clinical experience with radiation enhancement by hyperbaric oxygen in children with recurrent neuroblastoma stage IV.
abstract: The high risk group of patients with neuroblastoma are children over 1 year with stage IV disease. Most series report a maximum of 20% survival at 5 years. For recurrent neuroblastoma stage IV, cure rates are not reported in the literature, but they are nil. Any treatment for recurrent neuroblastoma stage IV remains a therapeutic dilemma. The outcome of radiation therapy is variable. A very important factor in tumour treatment remains tumour hypoxia, and others, such as metabolic factors, also play a role. Combined application of radiation modifiers may influence the final survival rate. In an attempt to improve the survival of recurrent neuroblastoma stage IV, hyperbaric oxygen and radioionated meta-Iodobenzylguanidine (MIBG) was used in a clinical setting. Although survival may not be used as a determinant of the usefulness of a treatment for stage IV neuroblastoma disease, a better one is not available. In this study, at 28 months, a cumulative probability of survival of 32% was recorded for patients treated with [131I]MIBG and hyperbaric oxygen compared to 12% for [131I]MIBG treatment alone. These preliminary results are promising but further studies are needed to reveal substantial therapeutic gain.
authors.affiliation: Department of Paediatric Oncology, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
authors.forename: P A
authors.initials: PA
authors.lastname: Voûte
authors.forename: A J
authors.initials: AJ
authors.lastname: van der Kleij
authors.forename: J
authors.initials: J
authors.lastname: De Kraker
authors.forename: C A
authors.initials: CA
authors.lastname: Hoefnagel
authors.forename: M M
authors.initials: MM
authors.lastname: Tiel-van Buul
authors.forename: H
authors.initials: H
authors.lastname: Van Gennip
mesh_terms: D019797:3-Iodobenzylguanidine; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006801:Humans; D006931:Hyperbaric Oxygenation; D007223:Infant; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D007462:Iodobenzenes / Q000627:therapeutic use*; D009364:Neoplasm Recurrence, Local; D009367:Neoplasm Staging; D009447:Neuroblastoma / Q000473:pathology / Q000532:radiotherapy*; D011836:Radiation Tolerance; D015996:Survival Rate
chemical_list: D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D019797:3-Iodobenzylguanidine