title: Pharmacokinetics and presystemic hepatic first-pass elimination of a novel sigma receptor antagonist, DuP 734, in the rat.
authors.affiliation: Drug Metabolism and Pharmacokinetics Section, Stine-Haskell Research Center, DuPont Merck Pharmaceutical Company, Newark, DE 19714, USA.
authors.forename: R P
authors.initials: RP
authors.lastname: Kapil
authors.forename: G N
authors.initials: GN
authors.lastname: Lam
mesh_terms: D000284:Administration, Oral; D000818:Animals; D014150:Antipsychotic Agents / Q000097:blood / Q000493:pharmacokinetics*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D007262:Infusions, Intravenous; D007408:Intestinal Absorption; D008099:Liver / Q000378:metabolism*; D008297:Male; D010880:Piperidines / Q000097:blood / Q000493:pharmacokinetics*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017480:Receptors, sigma / Q000037:antagonists & inhibitors*; D012702:Serotonin Antagonists / Q000097:blood / Q000493:pharmacokinetics*; D014018:Tissue Distribution
chemical_list: D014150:Antipsychotic Agents; D010880:Piperidines; D017480:Receptors, sigma; D012702:Serotonin Antagonists; C078773:DuP 734