title: Affected-sib-pair mapping of a novel susceptibility gene to insulin-dependent diabetes mellitus (IDDM8) on chromosome 6q25-q27.
abstract: Affected-sib-pair analyses were performed using 104 Caucasian families to map genes that predispose to insulin-dependent diabetes mellitus (IDDM). We have obtained linkage evidence for D6S446 (maximum lod score [MLS] = 2.8) and for D6S264 (MLS = 2.0) on 6q25-q27. Together with a previously reported data set, linkage can be firmly established (MLS = 3.4 for D6S264), and the disease locus has been designated IDDM8. With analysis of independent families, we confirmed linkage evidence for the previously identified IDDM3 (15q) and DDM7 (2q). We also typed additional markers in the regions containing IDDM3, IDDM4, IDDM5, and IDDM8. Preliminary linkage evidence for a novel region on chromosome 4q (D4S1566) has been found in 47 Florida families (P < .03). We also found evidence of linkage for two regions previously identified as potential linkages in the Florida subset: D3S1303 on 3q (P < .04) and D7S486 on 7q (P < .03). We could not confirm linkage with eight other regions (D1S191, D1S412, D4S1604, D8S264, D8S556, D10S193, D13S158, and D18S64) previously identified as potential linkages.
authors.affiliation: Department of Pathology, College of Medicine, University of Florida, Gainesville 32610, USA.
authors.forename: D F
authors.initials: DF
authors.lastname: Luo
authors.forename: M M
authors.initials: MM
authors.lastname: Bui
authors.forename: A
authors.initials: A
authors.lastname: Muir
authors.forename: N K
authors.initials: NK
authors.lastname: Maclaren
authors.forename: G
authors.initials: G
authors.lastname: Thomson
authors.forename: J X
authors.initials: JX
authors.lastname: She
mesh_terms: D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11; D002884:Chromosomes, Human, Pair 15; D002896:Chromosomes, Human, Pair 6; D004276:DNA, Satellite / Q000032:analysis; D003922:Diabetes Mellitus, Type 1 / Q000235:genetics*; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D020022:Genetic Predisposition to Disease; D006801:Humans; D008126:Lod Score; D009679:Nuclear Family
chemical_list: D004276:DNA, Satellite