Considerations in the design and production of small anti-receptor antibody forms: optimizing gains while reducing size.
Recent advances which have lead to the cloning of numerous immunoglobulin genes has resulted in the production of a variety of recombinant small antibody-like molecules. These smaller immunoglobulin derived molecules have potential for the development of diagnostic and pharmaceutical compounds. The considerations in the design and production of smaller antibody-like molecules and their clinical applications will be summarized in this review.
Peterson
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NC
Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Greene
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MI
D000911:Antibodies, Monoclonal / Q000737:chemistry*; D000915:Antibody Affinity; D005818:Genetic Engineering; D006801:Humans; D007140:Immunoglobulin Fab Fragments / Q000276:immunology*; D007128:Immunoglobulin Fragments / Q000276:immunology*; D007143:Immunoglobulin Heavy Chains / Q000737:chemistry; D007135:Immunoglobulin Variable Region / Q000737:chemistry*; D011994:Recombinant Proteins
D000911:Antibodies, Monoclonal; D007140:Immunoglobulin Fab Fragments; D007128:Immunoglobulin Fragments; D007143:Immunoglobulin Heavy Chains; D007135:Immunoglobulin Variable Region; D011994:Recombinant Proteins; C055966:immunoglobulin Fv