title: [Pharmacokinetics and bioavailability of glipizide capsules].
abstract: The pharmacokinetics and bioavailability of glipizide were studied in 8 healthy male volunteers after a single oral dose of 5 mg in capsule or in tablet. The plasma levels of glipizide were assayed by high performance liquid chromatography. The concentration--time curves of both preparations were fitted to a one compartment model. The pharmacokinetic parameters of glipizide in capsule and in tablet were shown in tables 2 and 3. The relative bioavailability of the capsule was 109.9% compared with the tablet.
authors.affiliation: Zhongshan Hospital of Shanghai.
authors.forename: Q C
authors.initials: QC
authors.lastname: Chen
authors.forename: C Q
authors.initials: CQ
authors.lastname: Yang
authors.forename: C H
authors.initials: CH
authors.lastname: Chao
authors.forename: Y G
authors.initials: YG
authors.lastname: Ma
authors.forename: X N
authors.initials: XN
authors.lastname: Li
authors.forename: W L
authors.initials: WL
authors.lastname: Chen
mesh_terms: D000328:Adult; D001682:Biological Availability; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D005913:Glipizide / Q000493:pharmacokinetics*; D006801:Humans; D008297:Male
chemical_list: D002214:Capsules; D005913:Glipizide