title: Effects of diltiazem and verapamil on ADP-induced rabbit platelet shape change and aggregation.
abstract: 1. The effects of diltiazem and verapamil (two structurally different calcium channel blockers) were examined on the rabbit platelets shape change and aggregation induced by adenosine-5'-diphosphate (ADP). 2. ADP was a much more potent stimulator on inducing platelet shape change (ED50 = 1 x 10(-7)) than platelet aggregation (ED50 = 1.78 x 10(-6)). 3. Both drugs similarly inhibited ADP-induced platelet shape change and aggregation at concentrations more than 300 microM. 4. There were no significant differences in inhibitory effects of either diltiazem or verapamil on ADP-induced platelet shape change and aggregation. 5. The inhibitory effects of diltiazem and verapamil on ADP-induced platelet shape change and aggregation at high concentrations may be due to their non specific properties.
authors.affiliation: Department of Pharmacology, Faculty of Medicine, Tehran University of Medical Sciences, Iran.
authors.forename: A R
authors.initials: AR
authors.lastname: Dehpour
authors.forename: T
authors.initials: T
authors.lastname: Samadian
authors.forename: M M
authors.initials: MM
authors.lastname: Akhavan
authors.forename: F
authors.initials: F
authors.lastname: Meysamee
authors.forename: A
authors.initials: A
authors.lastname: Delfan
mesh_terms: D000244:Adenosine Diphosphate / Q000494:pharmacology*; D000818:Animals; D001792:Blood Platelets / Q000187:drug effects*; D002121:Calcium Channel Blockers / Q000494:pharmacology; D004110:Diltiazem / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects*; D011817:Rabbits; D014700:Verapamil / Q000494:pharmacology*
chemical_list: D002121:Calcium Channel Blockers; D000244:Adenosine Diphosphate; D014700:Verapamil; D004110:Diltiazem