Effects of long-term zearalenone administration on spermatogenesis and serum luteinizing hormone, follicle-stimulating hormone, and prolactin values in male rats.
Body and testis weights, serum luteinizing hormone, follicle-stimulating hormone, and prolactin values and volume fractions of Sertoli cells, spermatogonia, early and late primary spermatocytes, and round and long spermatids were evaluated in 70-day-old male rates treated orally with 20 mg of zearalenone/kg of body weight daily for 5 weeks. Significant (P < 0.05) increase in serum prolactin concentration was consistently observed during the 5 weeks of treatment with zearalenone. Significant changes were not observed in any of the other variables evaluated.
Milano
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Departamento de Fisiopatología, Facultad de Ciencias Veterinarias, Universidad del Centro de la Provincia de Buenos Aires, Argentina.
Becú-Villalobos
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Tapia
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D000818:Animals; D005640:Follicle Stimulating Hormone / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D008297:Male; D009929:Organ Size; D011388:Prolactin / Q000097:blood*; D051381:Rats; D017208:Rats, Wistar; D012016:Reference Values; D012708:Sertoli Cells / Q000187:drug effects* / Q000502:physiology; D013087:Spermatids / Q000166:cytology / Q000187:drug effects; D013090:Spermatocytes / Q000166:cytology / Q000187:drug effects; D013091:Spermatogenesis / Q000187:drug effects*; D013093:Spermatogonia / Q000166:cytology / Q000187:drug effects; D013094:Spermatozoa / Q000166:cytology* / Q000187:drug effects; D013737:Testis / Q000187:drug effects; D013997:Time Factors; D015025:Zearalenone / Q000008:administration & dosage / Q000494:pharmacology*
D015025:Zearalenone; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone