Biochemical and electrophysiological effects of 7-OH-DPAT on the mesolimbic dopaminergic system.
Systemic administration of the putative selective D3 receptor agonist 7-hydroxy-2-(N,N-di-n-propylamino)tetralin (7-OH-DPAT) consistently decreased extracellular dopamine and 3,4-dihydroxyphenylacetic acid (DOPAC) levels in the nucleus accumbens and dopaminergic neuronal activity in the ventral tegmental area. 7-OH-DPAT inhibited dopamine release in the nucleus accumbens also when locally perfused through the dialysis probe. The results suggest the possibility that stimulation of dopamine D3 receptors with 7-OH-DPAT mimic biochemical and electrophysiological actions previously ascribed to D2 autoreceptor stimulation; however the lack of selective D3 antagonist precludes any firm conclusion in this sense.
Devoto
P
P
Bernard B. Brodie Department of Neuroscience, University of Cagliari, Italy.
Collu
M
M
Muntoni
A L
AL
Pistis
M
M
Serra
G
G
Gessa
G L
GL
Diana
M
M
D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D018491:Dopamine Agonists / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004594:Electrophysiology; D008297:Male; D017551:Microdialysis; D009714:Nucleus Accumbens / Q000187:drug effects* / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013681:Tegmentum Mesencephali / Q000187:drug effects* / Q000378:metabolism; D013764:Tetrahydronaphthalenes / Q000494:pharmacology*; D013997:Time Factors
D018491:Dopamine Agonists; D013764:Tetrahydronaphthalenes; C031349:7-hydroxy-2-N,N-dipropylaminotetralin; D004298:Dopamine