title: Clinical and preclinical photodynamic therapy.
abstract: Photodynamic therapy (PDT) is a treatment modality that utilizes a photosensitizing drug activated by laser generated light, and is proving effective for oncologic and nononcologic applications. This report provides an overview of photosensitizers, photochemistry, photobiology, and the lasers involved in photodynamic therapy. Clinical and preclinical PDT studies involving Photofrin and various second generation photosensitizers are reviewed.
authors.affiliation: Clayton Ocular Oncology Center, Childrens Hospital Los Angeles, California 90027, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Fisher
authors.forename: A L
authors.initials: AL
authors.lastname: Murphree
authors.forename: C J
authors.initials: CJ
authors.lastname: Gomer
mesh_terms: D000818:Animals; D002986:Clinical Trials as Topic; D017324:Hematoporphyrin Derivative / Q000627:therapeutic use; D006801:Humans; D053685:Laser Therapy; D009369:Neoplasms / Q000188:drug therapy; D018462:Photobiology; D010777:Photochemistry; D010778:Photochemotherapy; D017319:Photosensitizing Agents / Q000737:chemistry / Q000145:classification / Q000627:therapeutic use; D014777:Virus Diseases / Q000188:drug therapy
chemical_list: D017319:Photosensitizing Agents; D017324:Hematoporphyrin Derivative