Effects of streptozotocin-induced diabetes on postpneumonectomy lung growth and connective tissue levels.
Diabetes is generally accompanied by abnormal levels of growth hormone and adrenal steroids, hormones known to modulate postpneumonectomy (post-PNX) compensatory lung growth. Thus, we examined the possibility that diabetes may affect post-PNX lung growth processes. Left PNX was performed in young diabetic rats (streptozotocin-induced; 75 mg/kg body weight) (DM-PNX) and in control rats (C-PNX), for comparison with sham-operated control rats (C-SHAM). The rats were permitted free access to food and water. Examination at day 7 after surgery showed that right lung absolute dry weight and absolute DNA, collagen and elastin contents were increased in C-PNX and DM-PNX rats (but only C-PNX values reached those of both lungs in C-SHAM rats). Body weights (BW) of DM-PNX rats were lower than those of C-PNX and C-SHAM rats. Lung DNA/BW in C-PNX and DM-PNX rats were comparable, and matched values for both lungs in C-SHAM rats. Lung dry weight/BW, collagen/BW, and elastin/BW in DM-PNX rats exceeded values in C-PNX rats and even more for values of both lungs in C-SHAM rats. Data of another experiment, comparing DM-PNX rats with body weight-matched (by food limitation) PNX and control rats (WMC-PNX and WMC-SHAM rats, respectively) indicated comparable lung absolute DNA contents in DM-PNX and WMC-PNX rats (which matched values for both lungs in WMC-SHAM rats), however, lung absolute collagen and elastic contents were greater in the DM-PNX rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Ofulue
A F
AF
Department of Pathology, University of British Columbia, Vancouver, Canada.
Thurlbeck
W M
WM
D000818:Animals; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000009:adverse effects; D001835:Body Weight / Q000187:drug effects; D003238:Connective Tissue / Q000187:drug effects* / Q000254:growth & development; D004247:DNA; D003921:Diabetes Mellitus, Experimental / Q000139:chemically induced*; D007274:Injections, Intraperitoneal; D008168:Lung / Q000187:drug effects* / Q000254:growth & development; D008297:Male; D011013:Pneumonectomy; D012313:RNA; D051381:Rats; D013311:Streptozocin / Q000008:administration & dosage* / Q000009:adverse effects
D000900:Anti-Bacterial Agents; D013311:Streptozocin; D012313:RNA; D004247:DNA