title: Apolipoprotein E genotypes and age of onset in early-onset familial Alzheimer's disease.
abstract: The effect of the apolipoprotein E (APOE) epsilon 4 allele on age of onset was analyzed in two groups of families with early-onset Alzheimer's disease (AD), (1) Volga German (VG) kindreds, in which AD is caused by an unknown locus and (2) early-onset non-VG families showing evidence of linkage to chromosome 14. The epsilon 4 allele did not have a detectable effect on age of onset in either group. This finding suggests some forms of early-onset familial AD are not modifiable by APOE status, or that AD can be caused by APOE-independent pathways.
authors.affiliation: Division of Medical Genetics, University of Washington, Seattle, USA.
authors.forename: E
authors.initials: E
authors.lastname: Levy-Lahad
authors.forename: A
authors.initials: A
authors.lastname: Lahad
authors.forename: E M
authors.initials: EM
authors.lastname: Wijsman
authors.forename: T D
authors.initials: TD
authors.lastname: Bird
authors.forename: G D
authors.initials: GD
authors.lastname: Schellenberg
mesh_terms: D017668:Age of Onset; D000368:Aged; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D005838:Genotype; D006801:Humans; D008875:Middle Aged; D013997:Time Factors
chemical_list: D001057:Apolipoproteins E