Successful management of congenital protein C deficiency with recurrent pregnancy loss.
A 29-year-old woman experienced unexplained intrauterine fetal death (IUFD) three times, at 16, 27 and 27 gestational weeks. She was found to be protein C-deficient and the existence of infarction in the placenta was suspected at 20 weeks' gestation during her fourth pregnancy. Both heparin and antithrombin III were administered until delivery of a small-for-dates but live baby. Massive infarction in the placenta was evident at term. Anticoagulation with heparin is a useful treatment approach for cases of recurrent IUFD with protein C deficiency.
Ogasawara
M
M
Department of Obstetrics and Gynecology, Nagoya City Medical School, Japan.
Sasa
H
H
Kajiura
S
S
Aoki
K
K
Yagami
Y
Y
D000328:Adult; D000925:Anticoagulants / Q000627:therapeutic use; D005260:Female; D005313:Fetal Death / Q000209:etiology* / Q000503:physiopathology / Q000517:prevention & control; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use; D006801:Humans; D007238:Infarction / Q000209:etiology / Q000503:physiopathology; D010920:Placenta / Q000098:blood supply; D011247:Pregnancy; D020151:Protein C Deficiency; D012008:Recurrence
D000925:Anticoagulants; D006495:Heparin, Low-Molecular-Weight