A new paclitaxel photoaffinity analog with a 3-(4-benzoylphenyl)propanoyl probe for characterization of drug-binding sites on tubulin and P-glycoprotein.
Ojima
I
I
Department of Chemistry, State University of New York at Stony Brook 11794-3400, USA.
Duclos
O
O
Dormán
G
G
Simonot
B
B
Prestwich
G D
GD
Rao
S
S
Lerro
K A
KA
Horwitz
S B
SB
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000345:Affinity Labels / Q000378:metabolism*; D000818:Animals; D000970:Antineoplastic Agents / Q000378:metabolism*; D001665:Binding Sites; D051379:Mice; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000378:metabolism*; D043823:Taxoids; D014404:Tubulin / Q000378:metabolism*
C096007:3'-N-(4-benzoyldihydrocinnamoyl)-3'-N-debenzoylpaclitaxel; D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000345:Affinity Labels; D000970:Antineoplastic Agents; D043823:Taxoids; D014404:Tubulin; D017239:Paclitaxel