title: Effect of aqueous solutions of sucralose on plaque pH.
abstract: OBJECTIVE
  To compare the effect on in vivo plaque pH of rinsing with an aqueous solution of sucralose (alone or in combination with maltodextrin or maltodextrin and dextrose) to the effect of rinsing with an aqueous solution of sucrose.
  
  
  METHODS
  Each solution (four in total) had a sweetness equivalent to two teaspoons of sucrose in 6 oz. of water. The four test solutions were administered randomly over four test visits (one solution per visit) to 10 subjects presenting 2-day resting plaque. Before, and at specified time intervals over 60 minutes following the rinse, in vivo plaque pH was monitored at six designated sites using a Beckman 3500 digital pH meter. Data were analyzed by ANOVA.
  
  
  RESULTS
  The mean pH minimum for the sucralose rinse (6.56) was significantly higher than the sucralose/maltodextrin (SM), sucralose/maltodextrin/dextrose (SMD), and sucrose rinses (6.15, 5.84, and 5.29, respectively). The mean delta pH (difference between resting and minimum pH) for the sucralose rinse (0.45) was significantly lower when compared to the SM (0.79), SMD (1.14), and sucrose (1.69) rinses. The differences seen in mean pH minimum and mean delta pH for the SM and SMD groups vs. the sucrose group were also statistically significant. Mean areas under the pH vs. time curve for the sucralose, SM and SMD rinses were all significantly less compared to the sucrose rinse. Rinsing with aqueous solutions of sucralose, or of sucralose in combination with maltodextrin and/or dextrose (commercially available formulations, of sucralose) was less acidogenic than rinsing with a sucrose solution of equivalent sweetness.
authors.affiliation: Division of Oral Biology, New Jersey Dental School, Newark 07103-2400, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Steinberg
authors.forename: F
authors.initials: F
authors.lastname: Odusola
authors.forename: J
authors.initials: J
authors.lastname: Yip
authors.forename: I D
authors.initials: ID
authors.lastname: Mandel
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D003773:Dental Plaque / Q000737:chemistry*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration / Q000187:drug effects; D008297:Male; D013395:Sucrose / Q000031:analogs & derivatives* / Q000494:pharmacology; D013549:Sweetening Agents / Q000494:pharmacology*
chemical_list: D013549:Sweetening Agents; D013395:Sucrose; C026285:trichlorosucrose