title: Molecular foundations of cancer: new targets for intervention.
abstract: Conceptual and practical advances in molecular medicine are changing our understanding of cancer pathogenesis. In time this should provide the opportunity to alter the natural history of many cancers.
authors.affiliation: National Cancer Institute, Bethesda, Maryland 20892, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Karp
authors.forename: S
authors.initials: S
authors.lastname: Broder
mesh_terms: D000818:Animals; D002453:Cell Cycle / Q000187:drug effects / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000037:antagonists & inhibitors* / Q000502:physiology; D016213:Cyclins / Q000037:antagonists & inhibitors* / Q000502:physiology; D006801:Humans; D008967:Molecular Biology; D009369:Neoplasms / Q000209:etiology* / Q000235:genetics / Q000503:physiopathology / Q000628:therapy; D016159:Tumor Suppressor Protein p53 / Q000502:physiology
chemical_list: D016213:Cyclins; D016159:Tumor Suppressor Protein p53; D018844:Cyclin-Dependent Kinases