Activated protein C resistance in a neonate with venous thrombosis.
A term infant had a life-threatening inferior venal caval thrombosis during the first 24 hours of life. The plasma from the infant and his mother was found to be resistant to activated protein C and to be heterozygous for the factor V mutation (FV Leiden) associated with this disorder. The presence of this hereditary disorder should be considered in infants with thrombosis and in infants with conditions predisposing them to thrombosis.
Kodish
E
E
Department of Pediatrics, Rainbow Babies and Childrens Hospital, Case Western Reserve University School of Medicine, Cleveland, Ohio 44106, USA.
Potter
C
C
Kirschbaum
N E
NE
Foster
P A
PA
D000990:Antithrombin III; D005165:Factor V / Q000032:analysis / Q000235:genetics; D005784:Gene Amplification; D005838:Genotype; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D016296:Mutagenesis; D010314:Partial Thromboplastin Time; D010375:Pedigree; D016133:Polymerase Chain Reaction; D011486:Protein C / Q000032:analysis*; D011517:Prothrombin Time; D013924:Thrombophlebitis / Q000175:diagnosis* / Q000235:genetics*
D011486:Protein C; D000990:Antithrombin III; D005165:Factor V