title: Fenoverine-induced rhabdomyolysis.
abstract: Fenoverine is a spasmolytic drug that inhibits calcium channel currents. We describe the clinicopathologic findings in two patients with fenoverine-induced rhabdomyolysis, of whom one died. A transient left-bundle-branch block was observed in both patients. In one case, pre-existing hepatic dysfunction may have induced accumulation of the drug. Concurrent treatment by fibrates, as observed in the second patient, may have been a predisposing factor for fenoverine-induced rhabdomyolysis. The incidence of muscular complications of fenoverine therapy could be reduced by avoidance of prescription of the drug in patients with hepatopathy or those being treated with cholesterol-lowering agents. Physicians should be aware of life-threatening adverse effects of apparently innocuous drugs.
authors.affiliation: Department of Toxicology, Université Paris 12, Créteil, France.
authors.forename: P
authors.initials: P
authors.lastname: Chariot
authors.forename: R
authors.initials: R
authors.lastname: Ratiney
authors.forename: F
authors.initials: F
authors.lastname: Le Maguet
authors.forename: V
authors.initials: V
authors.lastname: Fourestié
authors.forename: A
authors.initials: A
authors.lastname: Astier
authors.forename: R
authors.initials: R
authors.lastname: Gherardi
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000473:pathology; D009336:Necrosis / Q000139:chemically induced; D010276:Parasympatholytics / Q000009:adverse effects*; D010640:Phenothiazines / Q000009:adverse effects* / Q000032:analysis / Q000097:blood; D012206:Rhabdomyolysis / Q000139:chemically induced* / Q000473:pathology; D010879:Piperazines
chemical_list: D010276:Parasympatholytics; D010640:Phenothiazines; C048314:fenoverine; D010879:Piperazines