Nephrotoxicity of notexin in experimental mice.
Notexin, a well known neurotoxin, derived from tiger snake venom, was shown to have direct nephrotoxic properties in experimental mice. A single subcutaneous dose of 1.38 micrograms/kg body weight of notexin produced renal tubular and glomerular damage within 24 hours. Renal damage increased in severity proportional to the dose of notexin injected. At a high dose of notexin, thrombotic "spherules" were found in glomeruli. These thrombotic spherules have not been previously reported to be associated with notexin or snake venoms.
Zimmerman
S E
SE
Department of Anatomical Pathology, Prince Henry Hospital, Little Bay, Australia.
Yong
L C
LC
D000818:Animals; D004546:Elapid Venoms / Q000633:toxicity*; D005920:Glomerular Mesangium / Q000187:drug effects / Q000648:ultrastructure; D007606:Juxtaglomerular Apparatus / Q000187:drug effects / Q000473:pathology; D007674:Kidney Diseases / Q000139:chemically induced* / Q000473:pathology / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000187:drug effects / Q000473:pathology; D007684:Kidney Tubules / Q000187:drug effects / Q000473:pathology; D008297:Male; D051379:Mice; D009498:Neurotoxins / Q000633:toxicity*; D012079:Renal Circulation
D004546:Elapid Venoms; D009498:Neurotoxins; C005082:notexin