title: Chemotherapy plays a major role in the inhibition of catch-up growth during maintenance therapy for childhood acute lymphoblastic leukemia.
abstract: OBJECTIVE
  In children treated for acute lymphoblastic leukemia (ALL), catch-up growth occurs after cessation of therapy and not during maintenance therapy. In this study we investigated whether this inhibition of catch-up growth during maintenance treatment is attributable to the influence of chemotherapy or to the influence of corticosteroids.
  
  
  METHODS
  Forty-six children treated for ALL were included in the study. In 27 patients maintenance therapy comprised vincristine (VCR), prednisone (Pred), or dexamethasone (Dexa) alternated with 6-mercaptopurine (6-MP) and methotrexate (MTX) and 19 patients received maintenance therapy with 6-MP and MTX only. Treatment did not include cranial irradiation.
  
  
  RESULTS
  Statural growth during maintenance treatment was comparable in both groups over the study period of 1.5 years.
  
  
  CONCLUSIONS
  Chemotherapy with 6-MP and MTX, and not corticosteroids, is the main factor that prevents catch-up growth from occurring during maintenance therapy for ALL.
authors.affiliation: Department of Pediatric Oncology, University of Nijmegen, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: Groot-Loonen
authors.forename: B J
authors.initials: BJ
authors.lastname: Otten
authors.forename: M A
authors.initials: MA
authors.lastname: van t' Hof
authors.forename: R J
authors.initials: RJ
authors.lastname: Lippens
authors.forename: G B
authors.initials: GB
authors.lastname: Stoelinga
mesh_terms: D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006128:Growth / Q000187:drug effects; D006130:Growth Disorders / Q000139:chemically induced*; D006801:Humans; D007223:Infant; D008297:Male; D015122:Mercaptopurine / Q000008:administration & dosage / Q000009:adverse effects; D008727:Methotrexate / Q000008:administration & dosage / Q000009:adverse effects; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000188:drug therapy* / Q000503:physiopathology*
chemical_list: D015122:Mercaptopurine; D008727:Methotrexate