[Cerebral blood flow increase and P300 latency prolongation by intravenous injection of acetazolamide--investigation in lacunar cerebral infarction and healthy subjects].
The cerebral blood flow and the P300 were measured before and 20 minutes after intravenous injection of 17 mg/kg acetazolamide in 15 cases of lacunar cerebral infarction and 10 healthy subjects. In cerebral infarction, the study was performed within 2 weeks after the onset. The cerebral blood flow except the infarcted area was increased significantly by the intravenous injection of acetazolamide in the lacunar cerebral infarction group and the healthy subject group. The blood flow decrease around the infarcted area (intracerebral steal phenomenon) by the intravenous injection of acetazolamide was not observed in any case. The N200 latency and the P300 latency were prolonged significantly by the intravenous injection of acetazolamide in the lacunar cerebral infarction group and in the healthy subject group but the N100 latency and the P200 latency did not show any significant changes. Despite the increase in cerebral blood flow, cerebral function may be decreased by intravenous injection of acetazolamide.
Oishi
M
M
Department of Neurology, Nihon University School of Medicine, Tokyo, Japan.
Mochizuki
Y
Y
Hara
M
M
Takasu
T
T
D000086:Acetazolamide / Q000008:administration & dosage; D000328:Adult; D000368:Aged; D002544:Cerebral Infarction / Q000503:physiopathology*; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D005073:Evoked Potentials, Somatosensory / Q000187:drug effects*; D006801:Humans; D007275:Injections, Intravenous; D008875:Middle Aged; D011930:Reaction Time
D000086:Acetazolamide