Effect of omeprazole on changes in gastric and upper small intestine pH levels in patients with chronic pancreatitis.
Gastric and upper small intestine pH levels were measured continuously over 24 hours in patients with chronic pancreatitis, and values obtained before and after the administration of omeprazole were compared. Additionally, omeprazole was administered for 2 weeks and the fecal excretion of fat was compared before and after drug therapy. Postprandial gastric pH levels, initially 2.9 to 3.2, increased by 1.6 to 2.1 after treatment. Postprandial upper small intestine pH levels, initially 5.1 to 5.5, increased by 0.7 to 1.0. The lowest pH value of the upper small intestine was 2.2 to 2.4 postprandially; this was increased by > 1.0 after omeprazole, and the amplitude of pH variation was reduced. The cumulative proportions of intraintestinal pH strata of < or = 3, < or = 4, or < or = 5, and higher, initially being 16.4% to 17.1%, 27.4% to 31.7%, and 52.6% to 57.8%, respectively, were remarkably improved after drug treatment. Gastric pH and upper small intestine pH levels showed a positive correlation; an increase in gastric pH levels by 2 corresponded to an increase in small intestine pH levels by 1. After omeprazole administration, mean fecal excretion of fat was decreased to 4.1 +/- 2.6 g/d (range, 1.1 to 9.8 g/d) from 6.5 +/- 3.9 g/d (range, 1.6 to 13.5 g/d). Decreases in excretion of fat averaged 3.4 g/d (range, 2.2 to 4.5 g/d) in patients with steatorrhea. It was concluded that steatorrhea due to chronic pancreatitis can be improved to some extent by improving upper small intestine pH levels following the elevation of gastric pH levels after administration of omeprazole.
Nakamura
T
T
Third Department of Internal Medicine, Hirosaki University School of Medicine, Aomori, Japan.
Arai
Y
Y
Tando
Y
Y
Terada
A
A
Yamada
N
N
Tsujino
M
M
Imamura
K
K
Machida
K
K
Kikuchi
H
H
Takebe
K
K
D000328:Adult; D000897:Anti-Ulcer Agents / Q000494:pharmacology*; D002908:Chronic Disease; D004041:Dietary Fats / Q000494:pharmacology; D005243:Feces / Q000737:chemistry; D018565:Food-Drug Interactions; D005744:Gastric Acid / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007421:Intestine, Small / Q000187:drug effects / Q000378:metabolism*; D050356:Lipid Metabolism; D008875:Middle Aged; D009853:Omeprazole / Q000494:pharmacology*; D010195:Pancreatitis / Q000097:blood / Q000150:complications / Q000378:metabolism*; D054328:Proton Pump Inhibitors
D000897:Anti-Ulcer Agents; D004041:Dietary Fats; D054328:Proton Pump Inhibitors; D009853:Omeprazole