[Successful treatment of acquired F:VIII C inhibitor after delivery using plasmapheresis and high doses of immunoglobulins].
Three months after delivery a patient 34 years of age was admitted to the Clinic of haematology in Novi Sad because of sudden massive bleeding from the left ankle, left lower leg as well as for having small haematomas visible at forearms. Examining the mechanism of haemostasis, a diagnosis was made: acquired inhibitor VIII:C coagulation factor. Concentrate of VIII coagulation factor was used in treatment, as well as plasmaphaeresis, high doses of immunoglobulins and immunosuppressive drugs: prednisone and azathioprime. The result was a very quick recovery of the clinical state with loss of inhibitor to VIII: C coagulation factor. Three years after the treatment the patient has no difficulties and no antibodies to VIII:C coagulation factor.
Belić
A
A
Institut za interne bolesti, Klinika za hematologiju, Medicinski fakultet, Novi Sad.
Pejin
D
D
Canak
V
V
Felle
D
D
Lucić
A
A
D000328:Adult; D001323:Autoantibodies / Q000096:biosynthesis*; D001778:Blood Coagulation Disorders / Q000628:therapy; D005169:Factor VIII / Q000276:immunology* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D010956:Plasmapheresis; D011644:Puerperal Disorders / Q000628:therapy*
D001323:Autoantibodies; D016756:Immunoglobulins, Intravenous; D005169:Factor VIII
Uspesno lecenje stecenog inhibitora F:VIII C nakon porodaja primenom plazmafereze i visokih doza imunoglobulina.