Clastogenicity of anthraquinones in V79 and in three derived cell lines expressing P450 enzymes.
The clastogenicity of seven anthraquinones was investigated in a V79 Chinese hamster cell line expressing only the reductive pathway enzymes and in three derived cell lines transfected and expressing three rat cytochrome P450 (1A1, 1A2, 2B1). The results have shown that chromosomal aberrations are modulated in similar manner both in parental and transfected V79 cell lines, suggesting that the clastogenicity of these compounds is not mediated by cytochrome P450 dependent monooxygenases.
Simi
S
S
Genetica e Biochimica Tossicologica, Istituto di Mutagenesi e Differenziamento CNR, Pisa, Italy.
Morelli
S
S
Gervasi
P G
PG
Rainaldi
G
G
D000818:Animals; D000880:Anthraquinones / Q000633:toxicity*; D002460:Cell Line; D002869:Chromosome Aberrations; D002999:Clone Cells; D006224:Cricetinae; D003412:Cricetulus; D003577:Cytochrome P-450 Enzyme System / Q000096:biosynthesis / Q000378:metabolism*; D009153:Mutagens / Q000633:toxicity*; D051381:Rats; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000378:metabolism; D013329:Structure-Activity Relationship
D000880:Anthraquinones; D009153:Mutagens; D011994:Recombinant Proteins; D003577:Cytochrome P-450 Enzyme System