Risk of solid tumors after irradiation in infancy.
Cancer incidence was studied in 14,351 subjects exposed to ionizing radiation for skin hemangioma at the Radiumhemmet, 1920-1959. Record-linkage was done with the Swedish Cancer Registry for the period 1958-1986. After a mean follow-up of 39 years, 300 cancers were observed and the standardized incidence ratio (SIR) was 1.11 (95% confidence interval (CI) 0.99-1.24). The absorbed dose to different organs varied from < 0.01 Gy to > 40 Gy. The thyroid cancer incidence was significantly increased (SIR = 2.28; 95% CI 1.33-3.65) and for cancer of the breast SIR was 1.24 (95% CI 0.98-1.54). Regarding pancreatic cancer and tumors of the endocrine glands the statistically significantly increased SIRs were based on a small number of cases and might therefore only be a coincidence. No confirmed increased incidence could be established for other cancer sites.
Lundell
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Department of Hospital Physics, Karolinska Hospital, Stockholm, Sweden.
Holm
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D000293:Adolescent; D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000453:epidemiology; D002648:Child; D015331:Cohort Studies; D016001:Confidence Intervals; D004307:Dose-Response Relationship, Radiation; D004701:Endocrine Gland Neoplasms / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006391:Hemangioma / Q000532:radiotherapy*; D006801:Humans; D015994:Incidence; D007223:Infant; D008297:Male; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D010190:Pancreatic Neoplasms / Q000453:epidemiology; D011878:Radiotherapy / Q000009:adverse effects; D011879:Radiotherapy Dosage; D012042:Registries; D012307:Risk Factors; D012878:Skin Neoplasms / Q000532:radiotherapy*; D013548:Sweden / Q000453:epidemiology; D013964:Thyroid Neoplasms / Q000453:epidemiology