Prediction of primate splice junction gene sequences with a cooperative knowledge acquisition system.
We propose a cooperative conceptual modelling environment in which two agents interact: the machine and the human expert. The former is able to extract knowledge from data using a symbolic-numeric machine learning system, and the latter is able to control the learning process by accepting and validating the machine results, or by criticizing those results or the explanation that the system produces on them. The improvement of the conceptual modelling relies on the cooperation between the two agents. Results obtained with our method on prediction of primate splice junctions sites in genetic sequences are far better than those reported in the literature with other symbolic machine learning systems, and are as better as those obtained with some artificial neural networks methods reported at present. But in opposite to neural networks which lack of argumentation, our system provides the user a plausible explanation of its prediction.
Mephu Nguifo
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Laboratoire d'Informatique, de Robotique et de Micro-electronique de Montpellier, France.
Sallantin
J
J
D000465:Algorithms; D000818:Animals; D001185:Artificial Intelligence; D001483:Base Sequence; D005091:Exons / Q000235:genetics; D005103:Expert Systems; D005544:Forecasting; D007438:Introns / Q000235:genetics; D008969:Molecular Sequence Data; D011323:Primates / Q000235:genetics*; D012326:RNA Splicing; D017422:Sequence Analysis, DNA / Q000379:methods*; D014584:User-Computer Interface