Neutrophilic dermatoses during granulocytopenia.
METHODS
Noninfectious cutaneous neutrophilic lesions can occur during granulocytopenia, but their mechanism remains unknown. We undertook a retrospective study of the neutrophilic dermatoses that developed during granulocytopenia induced by chemotherapy for acute myelogenous leukemia.


RESULTS
Seven men and one woman were included (2.6% of treated cases of acute myelogenous leukemia); half had acute myelogenous leukemia subtypes 4 and 5. The male-to-female ratio was 7:1. Neutrophilic eccrine hidradenitis was diagnosed in five cases, Sweet's syndrome in two cases, and difficult-to-classify neutrophilic dermatoses in one case. Cutaneous lesions appeared 12.5 days after the start of chemotherapy, and the mean leukocyte count was 0.426 x 10(9)/L. Three patients needed corticosteroids systemically.


CONCLUSIONS
Neutrophilic dermatoses during chemotherapy-induced granulocytopenia seem to occur more frequently in men with acute myelogenous leukemia subtypes 4 and 5.
Aractingi
S
S
Department of Dermatology, Hôpital Saint-Louis, Paris, France.
Mallet
V
V
Pinquier
L
L
Chosidow
O
O
Vignon-Pennamen
M D
MD
Degos
L
L
Dubertret
L
L
Dombret
H
H
D000328:Adult; D000368:Aged; D000380:Agranulocytosis / Q000150:complications*; D005260:Female; D016575:Hidradenitis / Q000209:etiology* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009504:Neutrophils / Q000473:pathology; D012189:Retrospective Studies; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology; D016463:Sweet Syndrome / Q000209:etiology* / Q000473:pathology