title: Focal 2-DG uptake persists following olfactory bulb lesions.
abstract: Exposure of rats to different odors produces spatially distinct patterns of 14C-2-deoxyglucose uptake (2-DG) in the glomerular layer of the main olfactory bulb. However, lesions of specific regions of the bulb that reliably contain 2-DG foci reportedly do not impair the ability of rats to perform olfactory-guided behaviors, suggesting that the lesioned olfactory bulb retains odor-responsiveness. Because the absence of focal 2-DG incorporation in lesioned olfactory bulbs has not been verified by 2-DG autoradiography, it cannot be concluded that focal responses in the olfactory bulb do not contribute to the encoding of olfactory information. To examine the effects of bulb lesions on 2-DG uptake in the olfactory bulb, we placed lesions in specific regions of the bulb that reliably contain 2-DG foci. We then exposed rats to odors 3 or 6 weeks later to determine if the lesions effectively eliminated focal 2-DG uptake in these bulbs. The results indicate that lesioned olfactory bulbs contain focal regions of 2-DG uptake in response to odor stimulation.
authors.affiliation: Department of Psychobiology, University of California, Irvine 92717, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Guthrie
authors.forename: J
authors.initials: J
authors.lastname: Holmes
authors.forename: M
authors.initials: M
authors.lastname: Leon
mesh_terms: D000818:Animals; D003847:Deoxyglucose / Q000378:metabolism*; D008297:Male; D009812:Odorants; D009830:Olfactory Bulb / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D015203:Reproducibility of Results; D013268:Stimulation, Chemical; D013997:Time Factors
chemical_list: D003847:Deoxyglucose