title: Closantel intoxication in a dog.
abstract: A case of overdosage with closantel, a salicynalide derivative, in a dog is described. The dog received 6 times the recommended dosage. Closantel induced optic neuritis, retinal degeneration, partial deafness, hepatotoxicosis and myopathy. Only the blindness was irreversible. The therapy included albumin administration to reduce the acute toxicity of closantel.
authors.affiliation: Small Animal Clinic, Department of Internal Medicine, Faculty of Veterinary Medicine, University of Liege, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: McEntee
authors.forename: M
authors.initials: M
authors.lastname: Grauwels
authors.forename: C
authors.initials: C
authors.lastname: Clercx
authors.forename: M
authors.initials: M
authors.lastname: Henroteaux
mesh_terms: D000418:Albumins / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism; D001766:Blindness / Q000139:chemically induced / Q000662:veterinary; D056486:Chemical and Drug Induced Liver Injury; D003638:Deafness / Q000139:chemically induced / Q000662:veterinary; D004283:Dog Diseases / Q000139:chemically induced*; D004285:Dogs; D062787:Drug Overdose / Q000662:veterinary; D005500:Follow-Up Studies; D008099:Liver / Q000187:drug effects; D008107:Liver Diseases / Q000662:veterinary; D008297:Male; D009902:Optic Neuritis / Q000139:chemically induced / Q000662:veterinary; D012162:Retinal Degeneration / Q000139:chemically induced / Q000662:veterinary; D012458:Salicylanilides / Q000008:administration & dosage / Q000009:adverse effects* / Q000378:metabolism
chemical_list: D000418:Albumins; D000871:Anthelmintics; D012458:Salicylanilides; C023342:closantel