title: [Kinetics of 7-aminocephalosporanic acid in aqueous solutions].
abstract: Stability of 7-aminocephalosporanic acid (7-ACA) and desacetyl-7-ACA in aqueous solutions at the pH value higher than 6 and wide ranges of the temperature was studied. The kinetic parameters of the hydrolysis of the ester link in the molecule of 7-ACA and the openings of the betalactam link in the molecules of 7-ACA and desacetyl-7-ACA were estimated. It was shown that all the destruction processes were describable by the 1st order equations. A procedure for the calculation of the velocity constants of the above mentioned three processes by changes in the concentration of 7-ACA and desacetyl-7-ACA in the solutions is described.
authors.forename: V B
authors.initials: VB
authors.lastname: Kurochkina
authors.forename: E V
authors.initials: EV
authors.lastname: Larina
authors.forename: P S
authors.initials: PS
authors.lastname: Nys
authors.forename: G S
authors.initials: GS
authors.lastname: Libinson
mesh_terms: D001711:Biotransformation; D002384:Catalysis; D002511:Cephalosporins / Q000493:pharmacokinetics*; D004355:Drug Stability; D006863:Hydrogen-Ion Concentration; D012996:Solutions; D013696:Temperature; D014867:Water / Q000737:chemistry
chemical_list: D002511:Cephalosporins; D012996:Solutions; D014867:Water; C030735:7-aminocephalosporanic acid
vernacular_title: Kinetika prevrashchenniĭ 7-aminotsefalosporanovoĭ kisloty v vodnykh rastvorakh.