Experimental studies on human bronchial smooth muscle in vitro.
The aim of this study was the investigation of bronchial reactivity in human bronchial smooth muscle in vitro. In fact, the study has two purposes: to achieve the best methods of research on human bronchial strips reactivity in vitro; to reveal the effect of acetylcholine and histamine on bronchial smooth muscle; The contractile effect of acetylcholine appears at 10(-6) M in the organ-bath; the maximal acetylcholine contraction was obtained at 10(-3) M in the organ-bath. Histamine induced a maximal contraction at 10(-3) M, but a concentration of 10(-3) M in the organ bath had no effect.
Mihalas
G
G
Department of Physiology, University of Medicine and Pharmacy, Timişoara, Romania.
Petroiu
A
A
Siska
I
I
Tanasie
G
G
Mederle
C
C
Bunu
C
C
Schneider
F
F
D000109:Acetylcholine / Q000494:pharmacology; D000368:Aged; D001980:Bronchi / Q000187:drug effects / Q000502:physiology*; D016084:Bronchoconstriction / Q000502:physiology; D006632:Histamine / Q000494:pharmacology; D006801:Humans; D066298:In Vitro Techniques; D008297:Male; D008875:Middle Aged; D009130:Muscle, Smooth / Q000187:drug effects / Q000502:physiology*; D009994:Osmolar Concentration
D006632:Histamine; D000109:Acetylcholine