A molecular basis for T-dependent B cell activation.
This review has concentrated on the key molecules which regulate T-dependent B cell activation in the context of the structural architecture within secondary lymphoid tissue where B cell immune responses occur. CD40L clearly plays a key role in driving B cells to proliferate within germinal centers, and although the data is conflicting, there is some evidence that the induction of CD40L is dependent on costimulation through CD28.
Lane
P
P
Basel Institute for Immunology, Switzerland.
D000818:Animals; D001402:B-Lymphocytes / Q000276:immunology*; D018106:CD28 Antigens / Q000276:immunology; D019013:CD40 Antigens / Q000276:immunology; D002450:Cell Communication; D006801:Humans; D008213:Lymphocyte Activation; D008221:Lymphoid Tissue / Q000276:immunology; D008222:Lymphokines / Q000276:immunology; D013601:T-Lymphocytes / Q000276:immunology*
D018106:CD28 Antigens; D019013:CD40 Antigens; D008222:Lymphokines