title: Synthesis of 19-hydroxylated bile acids and identification of 3 alpha,7 alpha,12 alpha,19-tetrahydroxy-5 beta-cholan-24-oic acid in human neonatal urine.
abstract: The synthesis of 19-hydroxylated bile acids (3 alpha,19-dihydroxy-, 3 alpha,7 alpha,19-trihydroxy-, 3 alpha,12 alpha,19-trihydroxy- and 3 alpha,7 alpha,12 alpha,19-tetrahydroxy-5 beta-cholan-24-oic acids) was described. These synthesized 19-hydroxylated bile acids were used as standard samples for the analysis of bile acids in human urine by gas chromatography-mass spectrometry. 3 alpha,7 alpha,12 alpha,19-Tetrahydroxy-5 beta-cholan-24-oic acid was identified in neonatal urines (0.1-1.5 micrograms/ml and 1.5-7% of total bile acids).
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kurosawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nomura
authors.forename: R
authors.initials: R
authors.lastname: Mahara
authors.forename: T
authors.initials: T
authors.lastname: Yoshimura
authors.forename: A
authors.initials: A
authors.lastname: Kimura
authors.forename: S
authors.initials: S
authors.lastname: Ikegawa
authors.forename: M
authors.initials: M
authors.lastname: Tohma
mesh_terms: D001647:Bile Acids and Salts / Q000138:chemical synthesis* / Q000652:urine; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002793:Cholic Acids / Q000652:urine*; D008401:Gas Chromatography-Mass Spectrometry; D006801:Humans; D007231:Infant, Newborn
chemical_list: C096561:3,7,12,19-tetrahydroxycholanoic acid; D001647:Bile Acids and Salts; D002793:Cholic Acids