title: Short tandem repeat polymorphism linkage studies in a new family with X-linked mental retardation (MRX20).
abstract: A family with X-linked recessive mental retardation (XLMR) without other obvious manifestations (MRX20) was studied with 14 short tandem repeat polymorphism (STRP) markers. Two-point lod scores above 3 were obtained with DXS1003, DXYS1, DXS3, and DXS458. A multipoint lod score of 4.25 was obtained with peak at DXS1003. Recombination events identify a 55.6 cM interval between DXS1068 and DXS454, while a one unit support interval identifies 40 cM between MAOA and DXS458.
authors.affiliation: Department of Neurology, University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School, New Brunswick 08903, USA.
authors.forename: A
authors.initials: A
authors.lastname: Lazzarini
authors.forename: E S
authors.initials: ES
authors.lastname: Stenroos
authors.forename: T
authors.initials: T
authors.lastname: Lehner
authors.forename: V
authors.initials: V
authors.lastname: McKoy
authors.forename: B
authors.initials: B
authors.lastname: Gold
authors.forename: M K
authors.initials: MK
authors.lastname: McCormack
authors.forename: C S
authors.initials: CS
authors.lastname: Reid
authors.forename: J
authors.initials: J
authors.lastname: Ott
authors.forename: W G
authors.initials: WG
authors.lastname: Johnson
mesh_terms: D008040:Genetic Linkage; D006801:Humans; D008607:Intellectual Disability / Q000235:genetics*; D008126:Lod Score; D008297:Male; D010375:Pedigree; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D014960:X Chromosome