title: Genetic factors in early separation anxiety: implications for the genesis of adult anxiety disorders.
abstract: An important contemporary conceptualization of anxiety has suggested that heightened early separation anxiety is specifically associated with the risk of adult panic disorder, with hereditary factors underlying that cluster of anxiety disorders. Yet there is a dearth of studies examining whether early separation anxiety is inherited. The present twin study, based on a retrospective approach, revealed a substantial genetic contribution to separation anxiety in females but not in males, with unique environmental influences being important in both gender groups. Although speculative, an evolutionary explanation is offered to account for the apparent gender difference in the inheritance of early separation anxiety. It is hypothesized that, in some women, phylogenetic vestiges of separation anxiety may conflict with their need to compete in an individualistic manner in the modern workplace. Whether such an attachment-autonomy conflict accounts for the increased rate of panic disorder and agoraphobia in women is worthy of further study.
authors.affiliation: School of Psychiatry, University of New South Wales, Australia.
authors.forename: D
authors.initials: D
authors.lastname: Silove
authors.forename: V
authors.initials: V
authors.lastname: Manicavasagar
authors.forename: D
authors.initials: D
authors.lastname: O'Connell
authors.forename: A
authors.initials: A
authors.lastname: Morris-Yates
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000379:Agoraphobia / Q000175:diagnosis / Q000235:genetics / Q000523:psychology; D001008:Anxiety Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D001010:Anxiety, Separation / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D004200:Diseases in Twins / Q000235:genetics* / Q000523:psychology; D005260:Female; D005783:Gender Identity; D006801:Humans; D008297:Male; D008875:Middle Aged; D008957:Models, Genetic; D016584:Panic Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D010553:Personality Development; D012189:Retrospective Studies; D012307:Risk Factors; D012931:Social Environment; D014429:Twins, Dizygotic / Q000235:genetics / Q000523:psychology; D014430:Twins, Monozygotic / Q000235:genetics / Q000523:psychology