Increased p53 site-specific DNA binding in cells producing mutant p53.
Chemotherapeutic and DNA-damaging agents were found to increase p53 site-specific DNA binding in human breast and rat liver epithelial WBrasII cells which produce mutant p53. Increased p53 site-specific DNA binding by chemotherapeutic or DNA-damaging agents was also induced in transfected Saos-2 cells producing wild type or transforming mutant p53. Therefore, exposure of cells containing a transforming p53 mutant to chemotherapeutic or DNA-damaging agents may potentially enhance their transformation state and tumorigenic potential.
Dees
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Health Sciences Research Division, Oak Ridge National Laboratory, TN 37831-6109, USA.
Travis
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D000230:Adenocarcinoma; D000818:Animals; D000970:Antineoplastic Agents / Q000633:toxicity; D001483:Base Sequence; D001665:Binding Sites; D002273:Carcinogens / Q000633:toxicity; D002460:Cell Line; D016384:Consensus Sequence; D004247:DNA / Q000378:metabolism; D004249:DNA Damage; D004273:DNA, Neoplasm / Q000378:metabolism; D004268:DNA-Binding Proteins / Q000096:biosynthesis / Q000378:metabolism*; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D016296:Mutagenesis; D010957:Plasmids; D051381:Rats; D011916:Rats, Inbred F344; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000378:metabolism; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity; D014162:Transfection; D014407:Tumor Cells, Cultured; D016159:Tumor Suppressor Protein p53 / Q000096:biosynthesis / Q000378:metabolism*
D000970:Antineoplastic Agents; D002273:Carcinogens; D004273:DNA, Neoplasm; D004268:DNA-Binding Proteins; D011994:Recombinant Proteins; D016159:Tumor Suppressor Protein p53; D004958:Estradiol; D004247:DNA; D013755:Tetradecanoylphorbol Acetate