Get receptive to metabotropic glutamate receptors.
Glutamate activates not only ionotropic glutamate receptors, but also G-protein-coupled receptors, called metabotropic glutamate receptors. Recent studies have revealed that these metabotropic receptors share distinctive structural properties and that they form a subgroup within the heptahelical receptor family. The development of ligands that bind specifically to these receptors has provided a means of characterizing the important roles they play in the tuning of fast synaptic transmission, including the induction of long-term changes in synaptic strength. Their involvement in the control of movement, spatial and olfactory memory and nociception has recently been demonstrated.
Pin
J P
JP
UPR-CNRS 9023, Montpellier, France.
Bockaert
J
J
D000818:Animals; D018698:Glutamic Acid / Q000494:pharmacology*; D015394:Molecular Structure; D017470:Receptors, Glutamate / Q000145:classification* / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000502:physiology*; D013569:Synapses / Q000502:physiology
D017470:Receptors, Glutamate; D018094:Receptors, Metabotropic Glutamate; D018698:Glutamic Acid