title: [Clinical and immunogenetic aspects of children with local and multiple forms of primary tuberculosis].
abstract: Immunogenetic examination of 146 preschool children with local and multiple tuberculous lesions and 148 controls found out the key role of unfavourable premorbid background (low-quality BCG vaccine, family contacts, associated diseases) in the disease onset. General trends in systemic immunity shifts are characterized. These depend on the age, inflammation phase, severity of clinical symptoms. Representation of antigens HLA DR2, DR5, Cw2, Cw4 indicates that a child has a 5-9 times greater risk to develop tuberculosis. These data should be allowed for in forming groups of higher risk among children.
authors.forename: I F
authors.initials: IF
authors.lastname: Dovgaliuk
authors.forename: V V
authors.initials: VV
authors.lastname: Vatutina
authors.forename: S I
authors.initials: SI
authors.lastname: Kuz'mina
authors.forename: O L
authors.initials: OL
authors.lastname: Korolenok
mesh_terms: D000367:Age Factors; D002648:Child; D002675:Child, Preschool; D003165:Complement System Proteins / Q000276:immunology; D003937:Diagnosis, Differential; D015236:HLA-C Antigens / Q000032:analysis; D015802:HLA-DR2 Antigen / Q000032:analysis; D015805:HLA-DR5 Antigen / Q000032:analysis; D006801:Humans; D007223:Infant; D008214:Lymphocytes / Q000276:immunology; D012307:Risk Factors; D012397:Rosette Formation; D014376:Tuberculosis / Q000175:diagnosis* / Q000235:genetics* / Q000276:immunology
chemical_list: D015236:HLA-C Antigens; D015802:HLA-DR2 Antigen; D015805:HLA-DR5 Antigen; D003165:Complement System Proteins
vernacular_title: Klinicheskaia i immunogeneticheskaia kharakteristika deteĭ s lokal'nymi i mnozhestvennymi formami pervichnogo tuberkuleza.