Anti-inflammatory activity of amylin and CGRP in different experimental models of inflammation.
The anti-inflammatory activity of amylin was studied in different models of inflammation, and compared to that of CGRP. Both peptides were active against mouse ear oedema induced by croton oil and acetic acid-induced peritonitis in the rat. CGRP was more potent than amylin in both models. Pretreatment with CGRP 8-37 fragment blocked the anti-inflammatory activity of both peptides in croton oil ear oedema. No anti-inflammatory activity was evidenced against serotonin-induced rat paw oedema and plasma protein extravasation induced by dextran in rat skin. Our results suggest that amylin exerts anti-inflammatory activity only in inflammatory models characterized by a vascular component. This effect appears to be mediated by the involvement of CGRP receptors.
Clementi
G
G
Institute of Pharmacology, University of Catania School of Medicine, Italy.
Caruso
A
A
Cutuli
V M
VM
Prato
A
A
de Bernardis
E
E
Fiore
C E
CE
Amico-Roxas
M
M
D000682:Amyloid / Q000494:pharmacology*; D000704:Analysis of Variance; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D015740:Calcitonin Gene-Related Peptide / Q000494:pharmacology*; D003436:Croton Oil; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy; D058228:Islet Amyloid Polypeptide; D008297:Male; D051379:Mice; D051381:Rats; D017207:Rats, Sprague-Dawley
D000682:Amyloid; D000894:Anti-Inflammatory Agents, Non-Steroidal; D058228:Islet Amyloid Polypeptide; D003436:Croton Oil; D015740:Calcitonin Gene-Related Peptide