Increased aldosterone-18-glucuronide/tetrahydroaldosterone ratios in pregnancy.
In the present study the aldosterone-18-glucuronide and tetrahydroaldosterone values in 24 hour urine collections of healthy nonpregnant women, women with normal pregnancies and women with pregnancy induced hypertension (PIH) were compared. In pregnancy an elevated excretion of both aldosterone metabolites was found. The Q-ratio (aldosterone-18-glucuronide/tetrahydro-aldosterone+aldosterone-18-glu cur onide) was also increased compared to healthy nonpregnant women. The elevated Q-ratios point out to increased formation of aldosterone-18-glucuronide. This predominantly renal metabolite may reflect greater availability of aldosterone molecules for interaction with mineralocorticoid receptor in the kidney.
Wacker
J
J
Department of Obstetrics and Gynecology, University of Heidelberg, Germany.
Piel
P
P
Lewicka
S
S
Haack
D
D
Vecsei
P
P
Bastert
G
G
D000450:Aldosterone / Q000031:analogs & derivatives* / Q000652:urine; D016022:Case-Control Studies; D005260:Female; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000652:urine*; D011247:Pregnancy / Q000652:urine*; D011249:Pregnancy Complications, Cardiovascular / Q000652:urine*; D012016:Reference Values
C013282:tetrahydroaldosterone; C018447:aldosterone 18-glucuronide; D000450:Aldosterone