title: The effect of caffeine on the pharmacokinetics of acetaminophen in man.
abstract: The influence of caffeine (60 mg) was studied on the pharmacokinetic characteristics of acetaminophen (500 mg single dose) in ten healthy male human volunteers in a complete cross-over design. A high-performance liquid chromatography (HPLC) method was used to analyse serum drug concentrations. Caffeine caused a highly significant (p < 0.01) increase in AUC and AUMC, a significant (p < 0.05) increase in Cmax, and a significant (p < 0.05) decrease in clearance (C1/F) of acetaminophen. We conclude that caffeine taken in doses commonly available commercially or in a cup of coffee can significantly potentiate the therapeutic potential of acetaminophen in man.
authors.affiliation: Faculty of Pharmacy, Bahauddin Zakariya University, Multan, Pakistan.
authors.forename: N
authors.initials: N
authors.lastname: Iqbal
authors.forename: B
authors.initials: B
authors.lastname: Ahmad
authors.forename: K H
authors.initials: KH
authors.lastname: Janbaz
authors.forename: A U
authors.initials: AU
authors.lastname: Gilani
authors.forename: S K
authors.initials: SK
authors.lastname: Niazi
mesh_terms: D000082:Acetaminophen / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D000328:Adult; D018712:Analgesics, Non-Narcotic / Q000009:adverse effects / Q000097:blood / Q000493:pharmacokinetics*; D002110:Caffeine / Q000008:administration & dosage / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D002851:Chromatography, High Pressure Liquid; D003069:Coffee; D018592:Cross-Over Studies; D004338:Drug Combinations; D004357:Drug Synergism; D006207:Half-Life; D006801:Humans; D008297:Male
chemical_list: D018712:Analgesics, Non-Narcotic; D000697:Central Nervous System Stimulants; D003069:Coffee; D004338:Drug Combinations; D000082:Acetaminophen; D002110:Caffeine