Successful thrombolytic therapy using tissue-type plasminogen activator in Kawasaki disease.
Thrombolytic therapy using tissue-type plasminogen activator was performed in a 7-month-old boy with massive mural thrombi in large coronary aneurysms due to Kawasaki disease. Magnetic resonance imaging successfully demonstrated mural thrombi in both proximal and distal coronary aneurysms and their disappearance after thrombolytic therapy. We conclude that for preventing acute myocardial infarction and sudden death intravenous and intracoronary thrombolytic therapy with tissue-type plasminogen activator may help in infants and children with Kawasaki disease who have thrombi in coronary aneurysms.
Tsubata
S
S
Department of Pediatrics, Toyama Medical and Pharmaceutical University, Toyama City, Japan.
Ichida
F
F
Hamamichi
Y
Y
Miyazaki
A
A
Hashimoto
I
I
Okada
T
T
D003323:Coronary Aneurysm / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D017023:Coronary Angiography; D006331:Heart Diseases / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D006801:Humans; D007223:Infant; D018810:Magnetic Resonance Angiography; D008297:Male; D009080:Mucocutaneous Lymph Node Syndrome / Q000150:complications*; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000517:prevention & control; D010960:Plasminogen Activators / Q000627:therapeutic use*; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy*; D010959:Tissue Plasminogen Activator / Q000627:therapeutic use*
D010960:Plasminogen Activators; D010959:Tissue Plasminogen Activator