title: Whisker follicle removal affects somatotopy and innervation of other follicles in adult mice.
abstract: The present study shows that in the whisker-to-barrel pathway of adult mice surgical removal of three whisker follicles leads to the expansion of the functional cortical representation of the whiskers adjacent to the lesion into the deprived barrels within 8 months. Concomitant with this enlargement, there is an increase in follicular innervation of the corresponding whiskers. This reorganization of the peripheral innervation may be important for the observed reshaping of cortical somatotopy.
authors.affiliation: Laboratory of Cerebral Metabolism, National Institute of Mental Health, Bethesda, Maryland 20892, USA.
authors.forename: P
authors.initials: P
authors.lastname: Melzer
authors.forename: C B
authors.initials: CB
authors.lastname: Smith
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000502:physiology; D003847:Deoxyglucose; D005260:Female; D007839:Functional Laterality / Q000502:physiology; D005947:Glucose / Q000378:metabolism; D008279:Magnetic Resonance Imaging; D008297:Male; D051379:Mice; D009412:Nerve Fibers / Q000502:physiology; D009434:Neural Pathways / Q000254:growth & development / Q000502:physiology; D010525:Peripheral Nerves / Q000166:cytology / Q000502:physiology; D013003:Somatosensory Cortex / Q000254:growth & development / Q000378:metabolism / Q000502:physiology*; D014738:Vibrissae / Q000294:innervation / Q000502:physiology*
chemical_list: D003847:Deoxyglucose; D005947:Glucose