title: Work-related late asthmatic response induced by latex allergy.
abstract: BACKGROUND
  The occupational uses of latex gloves may be associated with asthma. Hypersensitivity to latex has been shown to be IgE-mediated. The asthmatic reaction to latex is usually early; however, the natural history of latex asthma is still unknown.
  
  
  OBJECTIVE
  The purposes of this study were to investigate asthmatic responses induced by natural rubber latex and to assess the long-term respiratory consequences of latex-induced asthma after removal from exposure.
  
  
  METHODS
  This report describes the clinical and immunologic study of six nurses with work-related respiratory and skin disorders induced by the use of latex gloves. To determine whether the symptoms induced by latex gloves were IgE-mediated, we assessed latex IgE antibody levels by skin prick tests (SPTs) and RASTs with latex extracts. To confirm work-related latex reactions, we assessed respiratory symptoms, skin reactions, and FEV1 after a glove exposure test and an inhalation provocation test with latex gloves. All subjects were followed up for 7 months to 7 years after the first observation.
  
  
  RESULTS
  All subjects had positive SPT and RAST responses to latex extracts, positive double prick test responses to latex gloves, and negative SPT responses to cornstarch and common allergens. Ten atopic and 10 nonatopic control subjects had negative SPT responses to latex and cornstarch extracts and negative double prick test responses to latex gloves. In three subjects latex allergy was associated with allergy to fruit (banana and chestnut). After the glove exposure test, four of six subjects had contact urticaria, all had rhinoconjunctivitis, and two had a late asthmatic response. The inhalation provocation test was performed on four subjects: all had rhinoconjunctivitis, two had urticaria and late asthmatic response, and one had laryngeal edema. A late asthmatic response was recorded in four subjects. Three subjects continued to have chronic asthma, and four subjects had increased nonspecific bronchial responsiveness 7 months to 7 years after being assigned to duties not involving latex gloves.
  
  
  CONCLUSIONS
  This study of six nurses shows that latex is a potential cause of occupational asthma, rhinoconjunctivitis, and urticaria-angioedema. Latex seems to include antigens that elicit IgE-mediated hypersensitivity and may cause a late asthmatic reaction. Occupational asthma caused by latex may lead to permanent respiratory disability, even after removal from exposure.
authors.affiliation: Department of Clinical Medicine, Pathology and Pharmacology, University of Perugia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Brugnami
authors.forename: A
authors.initials: A
authors.lastname: Marabini
authors.forename: A
authors.initials: A
authors.lastname: Siracusa
authors.forename: G
authors.initials: G
authors.lastname: Abbritti
mesh_terms: D000328:Adult; D001249:Asthma / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D005260:Female; D005500:Follow-Up Studies; D005932:Gloves, Surgical; D006801:Humans; D006967:Hypersensitivity / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D007073:Immunoglobulin E / Q000032:analysis / Q000276:immunology; D007840:Latex / Q000276:immunology*; D008297:Male; D016210:Methacholine Chloride; D009784:Occupational Diseases; D010366:Peak Expiratory Flow Rate; D012119:Respiration; D012882:Skin Tests; D013997:Time Factors
chemical_list: D007840:Latex; D016210:Methacholine Chloride; D007073:Immunoglobulin E