Extractum Fagopyri reduces atherosclerosis in high-fat diet fed rabbits.
A group of 30 male mongrel rabbits was divided into 3 subgroups: controls, animals receiving a high-fat diet (HFD) containing cholesterol and coconut oil, HFD + Extr. Fagopyri (EF) were treated for 12 weeks. Surface areas of lipid deposites after 12 weeks of treatment measured planimetrically in the intima of the aorta, averaged 86.5% in HFD-fed animals, but 68.6% in EF treated rabbits. The positive effect of EF was confirmed histopathologically. The finding of this study is that the EF administration results in the reduction of atherosclerotic plaque formation.
Wójcicki
J
J
Department of Experimental and Clinical Pharmacology, Medical Academy, Szczecin, Poland.
Barcew-Wiszniewska
B
B
Samochowiec
L
L
Rózewicka
L
L
D000818:Animals; D001011:Aorta / Q000473:pathology; D001161:Arteriosclerosis / Q000188:drug therapy* / Q000473:pathology; D002784:Cholesterol / Q000097:blood; D008078:Cholesterol, LDL / Q000097:blood; D004036:Diet, Atherogenic; D004041:Dietary Fats / Q000009:adverse effects*; D008077:Lipoproteins, LDL / Q000097:blood; D008297:Male; D010936:Plant Extracts / Q000627:therapeutic use*; D018515:Plant Leaves / Q000737:chemistry; D011817:Rabbits; D014280:Triglycerides / Q000097:blood
D008078:Cholesterol, LDL; D004041:Dietary Fats; D008077:Lipoproteins, LDL; D010936:Plant Extracts; D014280:Triglycerides; D002784:Cholesterol