title: Cytochemical localization of guanylyl cyclase activity in rabbit taste bud cells.
abstract: Guanylyl cyclase activity was cytochemically demonstrated in rabbit foliate taste buds. The enzymatic activity was localized in the apical portion (microvilli and neck) of taste bud cells. Especially strong activity was observed on the microvillous membrane of type I (dark) cells and often on a blunt process of type III cells. The microvilli of type II (light) cells showed weak enzymatic activity. Considering that the apical portion of taste cells is a likely site of interaction between taste stimuli and the cells, the results support the idea that cyclic GMP is involved in taste transduction.
authors.affiliation: Department of Oral Physiology, Matsumoto Dental College, Shiojiri, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Asanuma
authors.forename: H
authors.initials: H
authors.lastname: Nomura
mesh_terms: D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D019256:Cadmium Chloride; D002712:Chlorides / Q000494:pharmacology; D006152:Cyclic GMP / Q000502:physiology; D006162:Guanylate Cyclase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D006651:Histocytochemistry; D008297:Male; D008627:Mercuric Chloride / Q000494:pharmacology; D011817:Rabbits; D015398:Signal Transduction / Q000502:physiology; D013649:Taste / Q000502:physiology; D013650:Taste Buds / Q000166:cytology / Q000201:enzymology*; D017967:Zinc Compounds / Q000494:pharmacology
chemical_list: D002712:Chlorides; D017967:Zinc Compounds; D002104:Cadmium; D008627:Mercuric Chloride; C016837:zinc chloride; D006162:Guanylate Cyclase; D006152:Cyclic GMP; D019256:Cadmium Chloride