Strategies for production of pharmaceutical proteins in milk.
Although it is only a decade since the use of transgenic livestock for the production of pharmaceutical proteins in milk was first suggested, great progress has been made. There is every reason to expect that, as methods for the transfer of genomic clones are applied with efficient regulatory elements, many proteins will be produced at high concentrations in the milk of livestock species. In most cases, these proteins will be biologically active, however, it remains to be shown whether they will be identical in structure and function to the natural product.
Wilmut
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Roslin Institute, Midlothian, Scotland, UK.
Whitelaw
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CB
D000818:Animals; D000829:Animals, Domestic; D030801:Animals, Genetically Modified; D004622:Embryo, Mammalian; D015870:Gene Expression; D018014:Gene Transfer Techniques; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D008892:Milk / Q000378:metabolism*; D014176:Protein Biosynthesis; D013234:Stem Cells; D013678:Technology, Pharmaceutical