title: High frequency oscillation in newborn infants with respiratory failure.
abstract: OBJECTIVE
  To report ventilation strategies, survival and complications in 39 outborn infants treated with high frequency oscillatory ventilation (HFOV).
  
  
  METHODS
  Data were collected prospectively between 1 May 1992 and 31 December 1993 on all infants treated with HFOV who had severe respiratory failure despite optimal conventional ventilation.
  
  
  RESULTS
  Twenty-eight out of 39 (72%) survived. Of the 15 infants with birthweights < 1500 g, eight survived. Best survival rates were for infants with pulmonary interstitial emphysema with air leak (4/5) and for infants of birthweight > 1500 g with hyaline membrane disease (8/8), and meconium aspiration syndrome (7/7). Three infants deteriorated while on HFOV and required extracorporeal membrane oxygenation. Complications were: (i) development of pulmonary interstitial emphysema (1); (ii) recurrence of pneumothorax (3); (iii) hypotension (2); and (iv) bronchopulmonary dysplasia (9). One of the eight infants weighing < 1500 g who received HFOV in the first week of life developed periventricular haemorrhage.
  
  
  CONCLUSIONS
  The initial results of HFOV for severe failure were encouraging although a learning curve was encountered with its introduction.
authors.affiliation: Department of Neonatology, Royal Children's Hospital, Parkville, Victoria, Australia.
authors.forename: P N
authors.initials: PN
authors.lastname: McDougall
authors.forename: P M
authors.initials: PM
authors.lastname: Loughnan
authors.forename: N T
authors.initials: NT
authors.lastname: Campbell
authors.forename: M
authors.initials: M
authors.lastname: Hochmann
authors.forename: B J
authors.initials: BJ
authors.lastname: Timms
authors.forename: W W
authors.initials: WW
authors.lastname: Butt
mesh_terms: D006612:High-Frequency Ventilation; D006801:Humans; D007230:Infant, Low Birth Weight; D007231:Infant, Newborn; D008171:Lung Diseases / Q000628:therapy; D011446:Prospective Studies; D012131:Respiratory Insufficiency / Q000628:therapy*; D015996:Survival Rate; D013997:Time Factors; D016896:Treatment Outcome