title: Congener-specific bioavailability of PCDD/Fs and coplanar PCBs in cows: laboratory and field measurements.
abstract: To estimate congener-specific bioavailabilities for 17 PCDD/Fs in cows grazing near a MSW incinerator both a controlled lab study and a field study were performed. In the lab study the estimates were derived from the elevated concentrations in milk from two cows after administration of a single dose of contaminated fly ash. In the field study, located near a large MSW incinerator, daily samples of grass and milk collected over a period of 60 days were pooled to two monthly bulk samples. The concentrations in these bulk samples of grass and milk were used to estimate the bioavailabilities of the 17 PCDD/Fs as well as of three coplanar PCBs. With the concentrations of PCDD/Fs expressed in I-TEQs the bioavailability in cows was estimated at +/- 7.5% in the field study. The congener-specific bioavailabilities correlated well between the two studies, as well as with previously reported values in the literature. However, the absolute levels differed considerably between studies, indicating a strong matrix effect.
authors.affiliation: National Institute of Public Health and Environmental Protection (RIVM), Bilthoven, The Netherlands.
authors.forename: W
authors.initials: W
authors.lastname: Slob
authors.forename: M
authors.initials: M
authors.lastname: Olling
authors.forename: H J
authors.initials: HJ
authors.lastname: Derks
authors.forename: A P
authors.initials: AP
authors.lastname: de Jong
mesh_terms: D000818:Animals; D001682:Biological Availability; D002244:Carbon / Q000008:administration & dosage; D002417:Cattle / Q000378:metabolism*; D060729:Coal Ash; D005260:Female; D005506:Food Contamination / Q000032:analysis; D008892:Milk / Q000737:chemistry; D052638:Particulate Matter; D006109:Poaceae; D011078:Polychlorinated Biphenyls / Q000032:analysis / Q000493:pharmacokinetics*; D000072317:Polychlorinated Dibenzodioxins / Q000031:analogs & derivatives* / Q000032:analysis / Q000493:pharmacokinetics
chemical_list: D060729:Coal Ash; D052638:Particulate Matter; D000072317:Polychlorinated Dibenzodioxins; D002244:Carbon; D011078:Polychlorinated Biphenyls