Bone mineral density in patients with prostatic cancer treated with orchidectomy and with estrogens.
Bone mineral density (BMD) and bone mineral content (BMC) were measured in the femoral neck area, trochanteric area and Wards triangle, and in the distal radius of the left forearm before and after 1 year of endocrine treatment in 27 patients with prostatic cancer. Eleven of the patients were treated with orchidectomy and 16 with combined oral and intramuscular estrogens. The patients were free from metastases during the entire observation period. In the orchidectomized patients, BMD and BMC of the distal radius decreased significantly following treatment, whereas no changes were observed in the estrogen-treated patients. These preliminary results demonstrate that estrogens may protect bone in male subjects also and may merit further investigations on larger groups of patients.
Eriksson
S
S
Department of Orthopedics, Karolinska Institutet, Huddinge University Hospital, Sweden.
Eriksson
A
A
Stege
R
R
Carlström
K
K
D000368:Aged; D018931:Antineoplastic Agents, Hormonal / Q000627:therapeutic use*; D015519:Bone Density; D004958:Estradiol / Q000031:analogs & derivatives / Q000627:therapeutic use; D045166:Estradiol Congeners / Q000627:therapeutic use; D004967:Estrogens / Q000627:therapeutic use*; D004997:Ethinyl Estradiol / Q000627:therapeutic use; D006801:Humans; D008297:Male; D009919:Orchiectomy; D011471:Prostatic Neoplasms / Q000188:drug therapy / Q000503:physiopathology* / Q000628:therapy*
D018931:Antineoplastic Agents, Hormonal; D045166:Estradiol Congeners; D004967:Estrogens; D004997:Ethinyl Estradiol; D004958:Estradiol; C008958:polyestradiol phosphate