Influence of progesterone and its antagonist mifepristone (RU 486) on collagen content in uterine cervix in pregnant rats.
Total collagen and its soluble fraction as well as water content were determined in late pregnancy in the uterine cervix in a population of 36 rats treated with progesterone (n = 10), mifepristone (n = 13) and controls (n = 13). In both treated groups there were no signs of delivery on the 21st day of gestation. Water content was significantly lower in the mifepristone-treated group. A statistically higher soluble collagen fraction was observed in this group. The results obtained in the progesterone-treated group were not significantly different when compared to the controls. Significant differences were observed between progesterone- and mifepristone-treated groups in total and soluble fractions of collagen.
Bieńkiewicz
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Institute of Obstetrics and Gynecology, Medical University of Lódź, Poland.
D000818:Animals; D001834:Body Water / Q000378:metabolism; D002584:Cervix Uteri / Q000187:drug effects* / Q000378:metabolism*; D003094:Collagen / Q000378:metabolism*; D005260:Female; D015735:Mifepristone / Q000494:pharmacology*; D011247:Pregnancy; D011374:Progesterone / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D015735:Mifepristone; D011374:Progesterone; D003094:Collagen