Flavonoids as scavengers of nitric oxide radical.
Flavonoids are a group of naturally occurring compounds used, e.g., in the treatment of vascular endothelial damage. They are known to be excellent scavengers of oxygen free radicals. Since the nitric oxide radical (.NO) probably plays a role in this pathology, the .NO scavenging capacity of the flavonoids was determined. It was found that the flavonoids are very potent .NO scavengers. The anthocyanidins were found to be more effective scavengers than the hydroxyethylrutosides, which correlated with their therapeutic activity. The values of their scavenging rate constants are only 30 times less active than the very potent endogenous .NO scavenger haemoglobin. It is speculated that .NO scavenging plays a role in the therapeutic effect of the flavonoids.
van Acker
S A
SA
LACDR, Department of Pharmacochemistry, Faculty of Chemistry, Vrije Universiteit, Amsterdam, The Netherlands.
Tromp
M N
MN
Haenen
G R
GR
van der Vijgh
W J
WJ
Bast
A
A
D005419:Flavonoids; D016166:Free Radical Scavengers; D005609:Free Radicals; D007700:Kinetics; D009569:Nitric Oxide; D012431:Rutin; D013329:Structure-Activity Relationship
D005419:Flavonoids; D016166:Free Radical Scavengers; D005609:Free Radicals; D009569:Nitric Oxide; D012431:Rutin