Prostate cancer-induced oncogenic hypophosphatemic osteomalacia.
A 65-year-old male with prostate carcinoma showed mild hypocalcemia of 7.9 mg/dl, marked hypophosphatemia of 1.7 mg/dl, hyperphosphaturia (tubular reabsorption of phosphorus 43% and tubular threshold for phosphorus of 0.6 mg/dl), low serum 1,25 (OH)2D level of less than 5 pg/ml and osteomalacia indicated by a marked increase of relative osteoid volume and fractional formation rate in the undecalcified section. Oncogenic osteomalacia due to prostatic carcinoma with suppression of 1,25 (OH)2D production and phosphaturia was suggested.
Nakahama
H
H
Fifth Department of Internal Medicine, Hyogo College of Medicine, Japan.
Nakanishi
T
T
Uno
H
H
Takaoka
T
T
Taji
N
N
Uyama
O
O
Kitada
O
O
Sugita
M
M
Miyauchi
A
A
Sugishita
T
T
D000230:Adenocarcinoma / Q000150:complications*; D000368:Aged; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D017674:Hypophosphatemia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D008297:Male; D010018:Osteomalacia / Q000000981:diagnostic imaging / Q000209:etiology* / Q000473:pathology; D011471:Prostatic Neoplasms / Q000150:complications*; D011877:Radionuclide Imaging