title: Prognostic significance of heat-shock protein-27 in node-positive breast carcinoma: an immunohistochemical study.
abstract: Immunostaining for heat-shock protein-27 (HSP-27) was performed on formalin fixed-paraffin embedded sections of 890 node-positive breast carcinomas resected between 1980 and 1986. The follow-up ranged from 2.5 to 10.5 years. A polyclonal antibody (Hu27, dilution: 1/200) was used. A positive cytoplasmic staining was obtained in 383 cases (43%). No difference in distant metastasis-free survival (DMFS) or overall survival (OS) was noted between cases with positive or negative immunostaining. This study suggests that HSP-27 expression is not predictive of the outcome in node-positive breast cancer.
authors.affiliation: Department of Pathology, L'Hôtel-Dieu de Québec, Canada.
authors.forename: B
authors.initials: B
authors.lastname: Têtu
authors.forename: J
authors.initials: J
authors.lastname: Brisson
authors.forename: J
authors.initials: J
authors.lastname: Landry
authors.forename: J
authors.initials: J
authors.lastname: Huot
mesh_terms: D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D005500:Follow-Up Studies; D006360:Heat-Shock Proteins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D015999:Multivariate Analysis; D009363:Neoplasm Proteins / Q000032:analysis*; D011379:Prognosis
chemical_list: D006360:Heat-Shock Proteins; D009363:Neoplasm Proteins