Acute renal failure in high dose carboplatin chemotherapy.
Carboplatin has been reported to cause acute renal failure when administered in high doses to adult patients. We report a 4 1/2-year-old girl who was treated with high-dose carboplatin for metastatic parameningeal embryonal rhabdomyosarcoma. Acute renal failure developed followed by a slow partial recovery of renal function. Possible contributing factors are discussed.
Frenkel
J
J
Department of Paediatrics, Emma Kinderziekenhuis/Academic Medical Centre, University of Amsterdam, The Netherlands.
Kool
G
G
de Kraker
J
J
D058186:Acute Kidney Injury / Q000139:chemically induced*; D016190:Carboplatin / Q000009:adverse effects*; D002675:Child, Preschool; D005260:Female; D006801:Humans; D008577:Meningeal Neoplasms / Q000188:drug therapy / Q000556:secondary; D018233:Rhabdomyosarcoma, Embryonal / Q000188:drug therapy / Q000556:secondary
D016190:Carboplatin