title: The incidence and management of biliary complications following liver transplantation in children.
abstract: Biliary complications following liver transplantation are a cause of significant morbidity and mortality. During the period 1988-1993 ten cases of biliary complications occurred after 98 transplantations in 78 children. The complications were four bile leaks, three intrahepatic biliary strictures (one with recurrent cholangitis), two anastomotic biliary strictures (one with recurrent cholangitis) and one recurrent cholangitis. All leaks occurred within 6 weeks of transplantation whereas all strictures and cholangitic episodes occurred after 3 months. Two biliary complications (20%) - one intrahepatic and one anastomotic stricture - developed secondary to hepatic artery thrombosis. The incidence of biliary complications was 13.2% with whole liver grafts as compared to 6.7% with partial liver grafts and it was 4.3% with duct-to-duct anastomosis as compared to 12.0% with Roux-en-Y hepatico-jejunostomy. Seven children required intervention for management of biliary complications and three were managed conservatively. There were no deaths related to the biliary complications.
authors.affiliation: Liver Transplant Surgical Service, Kings College Hospital, Camberwell, London, UK.
authors.forename: V
authors.initials: V
authors.lastname: Bhatnagar
authors.forename: A
authors.initials: A
authors.lastname: Dhawan
authors.forename: H
authors.initials: H
authors.lastname: Chaer
authors.forename: P
authors.initials: P
authors.lastname: Muiesan
authors.forename: M
authors.initials: M
authors.lastname: Rela
authors.forename: A P
authors.initials: AP
authors.lastname: Mowat
authors.forename: R
authors.initials: R
authors.lastname: Williams
authors.forename: K C
authors.initials: KC
authors.lastname: Tan
authors.forename: N D
authors.initials: ND
authors.lastname: Heaton
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D002761:Cholangitis / Q000453:epidemiology* / Q000628:therapy; D002779:Cholestasis / Q000453:epidemiology* / Q000628:therapy; D005260:Female; D006801:Humans; D015994:Incidence; D007223:Infant; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male