Molecular cytogenetics of human breast cancer.
Our studies of human breast cancer using CGH and FISH with precisely mapped probes have revealed a surprising amount of intratumor and intertumor heterogeneity in human breast cancers. However, some regions of abnormal copy number are found frequently. We believe that the regions of frequent abnormality harbor novel cancer genes, and that identification of these is important for diagnosis, prognostication, and the development of new therapies.
Gray
J W
JW
Department of Laboratory Medicine, University of California, San Francisco 94143-0808, USA.
Collins
C
C
Henderson
I C
IC
Isola
J
J
Kallioniemi
A
A
Kallioniemi
O P
OP
Nakamura
H
H
Pinkel
D
D
Stokke
T
T
Tanner
M
M
D001943:Breast Neoplasms / Q000235:genetics*; D003582:Cytogenetics; D004273:DNA, Neoplasm / Q000235:genetics; D005260:Female; D005784:Gene Amplification; D016147:Genes, Tumor Suppressor; D015894:Genome, Human; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008967:Molecular Biology; D009693:Nucleic Acid Hybridization; D009857:Oncogenes; D014407:Tumor Cells, Cultured
D004273:DNA, Neoplasm