title: [Clinical effects and immunological analysis of intraabdominal and intrapleural injection of lentinan for malignant ascites and pleural effusion of gastric carcinoma].
abstract: Twenty-one patients with malignant peritoneal or pleural effusions of gastric carcinomas were treated with intracavitary injection of lentinan (LNT). LNT was injected at a dosage of 4 mg/week for 4 weeks. In total, fifteen (71%) of twenty-one patients demonstrated clinical responses. Toxicity caused a high fever in only one case. LAK and ATK activities induced from peritoneal exudate cells (PEC) after culture with autologous tumor and interleukin-2 were examined before and after LNT injection. ATK activity was augmented, but LAK activity was reduced after LNT injection. These results indicate that intracavitary injection of LNT is a useful treatment for malignant effusions, and that LNT augments the induction of cytotoxic T-lymphocytes.
authors.affiliation: Dept. of Surgery II, Yamaguchi University School of Medicine.
authors.forename: S
authors.initials: S
authors.lastname: Hazama
authors.forename: M
authors.initials: M
authors.lastname: Oka
authors.forename: S
authors.initials: S
authors.lastname: Yoshino
authors.forename: N
authors.initials: N
authors.lastname: Iizuka
authors.forename: K
authors.initials: K
authors.lastname: Wadamori
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: K
authors.initials: K
authors.lastname: Hirazawa
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.forename: Y
authors.initials: Y
authors.lastname: Ogura
authors.forename: Y
authors.initials: Y
authors.lastname: Masaki
mesh_terms: D000972:Antineoplastic Agents, Phytogenic / Q000627:therapeutic use*; D001202:Ascitic Fluid / Q000276:immunology* / Q000628:therapy; D006801:Humans; D015552:Injections, Intralesional; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D007912:Lentinan / Q000627:therapeutic use*; D016246:Lymphocytes, Tumor-Infiltrating / Q000276:immunology; D016066:Pleural Effusion, Malignant / Q000276:immunology* / Q000628:therapy; D013274:Stomach Neoplasms / Q000150:complications*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
chemical_list: D000972:Antineoplastic Agents, Phytogenic; D007912:Lentinan