[Increased gamma delta T cells in peripheral blood of patients with severe neurologic impairment].
We examined peripheral gamma delta T cells in patients with severe neurologic impairment. The gamma delta T cells in these patients significantly increased as compared with those in healthy adults (P < 0.0001). These cells expressed the V gamma 9/V delta 2 phenotype which was reported to proliferate by infections. When patients with severe neurologic impairment and patients with Duchenne muscular dystrophy (DMD) were divided into frequent and non-frequent infectious groups, the gamma delta T cells increased significantly in the frequent infectious group of DMD (P < 0.005), but not significantly in the frequent infectious group of patients with severe neurologic impairment. These results indicated that the gamma delta T cells of patients with severe neurologic impairment increased in frequent infections and other factor(s).
Hasui
M
M
Department of Pediatrics, National Sanatorium Io Hospital, Kanazawa, Ishikawa.
Honke
K
K
Takano
N
N
Okumura
S
S
Ishikawa
K
K
D000293:Adolescent; D000328:Adult; D004198:Disease Susceptibility / Q000276:immunology; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008297:Male; D008875:Middle Aged; D009136:Muscular Dystrophies / Q000276:immunology*; D009422:Nervous System Diseases / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000378:metabolism*
D016692:Receptors, Antigen, T-Cell, gamma-delta