Linkage of cell-mediated immunity to iron metabolism.
Iron is essential for growing microorganisms and tumour cells, and is also crucial for the proliferation of immune cells. In this review, Günter Weiss, Helmut Wachter and Dietmar Fuchs focus on the complex network of interactions that link iron metabolism with cellular immune effector functions involving cytokines and nitric oxide, and draw a suitable model for the pathogenesis of anaemia of chronic disease.
Weiss
G
G
Dept of Internal Medicine, University of Innsbruck Hospital, Austria.
Wachter
H
H
Fuchs
D
D
D000818:Animals; D006801:Humans; D007111:Immunity, Cellular; D007501:Iron / Q000378:metabolism*
D007501:Iron