title: Monomeric and dimeric forms of soluble receptors can differ in their neutralization potential.
abstract: Recombinant soluble forms of transmembrane receptors can be produced in monomeric and dimeric versions. Binding affinity and neutralization potential of these different forms of soluble receptors depend on the quaternary structure of their ligands. Monomeric ligands will be bound with equal affinity by both forms, whereas trimeric ligands, e.g. members of the tumor necrosis factor family of ligands, interact with much higher affinity with dimeric soluble receptors than with monomeric ones.
authors.affiliation: Research Laboratories of Behringwerke AG, Marburg, Germany.
authors.forename: L
authors.initials: L
authors.lastname: Lauffer
authors.forename: E J
authors.initials: EJ
authors.lastname: Kanzy
authors.forename: R
authors.initials: R
authors.lastname: Köhler
authors.forename: R
authors.initials: R
authors.lastname: Kurrle
authors.forename: K
authors.initials: K
authors.lastname: Enssle
authors.forename: F R
authors.initials: FR
authors.lastname: Seiler
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D015703:Antigens, CD / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism*; D001667:Binding, Competitive; D019013:CD40 Antigens / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism*; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000378:metabolism; D015847:Interleukin-4 / Q000378:metabolism; D007700:Kinetics; D046911:Macromolecular Substances; D051379:Mice; D008961:Models, Structural; D008969:Molecular Sequence Data; D018123:Receptors, Interleukin / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism*; D017472:Receptors, Interleukin-1 / Q000096:biosynthesis / Q000737:chemistry* / Q000378:metabolism*; D019948:Receptors, Interleukin-4; D011993:Recombinant Fusion Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D011994:Recombinant Proteins / Q000096:biosynthesis / Q000737:chemistry / Q000378:metabolism; D012795:Sialoglycoproteins / Q000378:metabolism
chemical_list: D015703:Antigens, CD; D019013:CD40 Antigens; C507763:IL1RN protein, human; C507764:Il1rn protein, mouse; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D046911:Macromolecular Substances; D018123:Receptors, Interleukin; D017472:Receptors, Interleukin-1; D019948:Receptors, Interleukin-4; D011993:Recombinant Fusion Proteins; D011994:Recombinant Proteins; D012795:Sialoglycoproteins; D015847:Interleukin-4