title: Phylogenetic analyses of the ATP-binding constituents of bacterial extracytoplasmic receptor-dependent ABC-type nutrient uptake permeases.
abstract: Thirty-eight ATP-binding cassette (ABC) protein constituents of bacterial extracytoplasmic receptor-dependent nutrient uptake systems, including one homologous chloroplast protein were analysed for sequence conservation and phylogenetic relatedness. The proteins were generally found to cluster in accordance with the clustering patterns previously observed for the extracytoplasmic receptors and the transmembrane channel-forming constituents of these permeases. The results suggest that these transport systems evolved from a single primordial system with minimal shuffling of the three dissimilar protein constituents of the systems.
authors.affiliation: Department of Biology, University of California at San Diego, La Jolla 92093-0116, USA.
authors.forename: G
authors.initials: G
authors.lastname: Kuan
authors.forename: E
authors.initials: E
authors.lastname: Dassa
authors.forename: W
authors.initials: W
authors.lastname: Saurin
authors.forename: M
authors.initials: M
authors.lastname: Hofnung
authors.forename: M H
authors.initials: MH
authors.lastname: Saier
mesh_terms: D018528:ATP-Binding Cassette Transporters / Q000145:classification* / Q000235:genetics; D000595:Amino Acid Sequence; D006090:Gram-Negative Bacteria / Q000737:chemistry* / Q000201:enzymology / Q000235:genetics; D006094:Gram-Positive Bacteria / Q000737:chemistry* / Q000201:enzymology / Q000235:genetics; D066298:In Vitro Techniques; D026901:Membrane Transport Proteins / Q000737:chemistry*; D008969:Molecular Sequence Data; D010802:Phylogeny
chemical_list: D018528:ATP-Binding Cassette Transporters; D026901:Membrane Transport Proteins