[Stress-induced analgesia. The role of the hormones of the hypophyseal-adrenocortical system].
The effect of stress on pain threshold and blood corticosteroids was studied in anesthetised rats. The stress stimulation resulted in a parallel changes of analgesia and blood corticosteroids. Stress-induced analgesia were decreased after blocking of the pituitary-adrenocortical system by means of dexamethasone implantation (200 micrograms) in paraventricular nucleus of hypothalamus or i. v. administration of hydrocortisone (15 mg/100 g b. w.). Naloxone administration (1, 10 mg/kg) does not block analgetic effect and corticosteroid level. These results suggest that pituitary-adrenocortical axis provide non opioid stress-induced analgesia.
Filaretov
A A
AA
Bogdanov
A I
AI
Iarushkina
N I
NI
D000305:Adrenal Cortex Hormones / Q000502:physiology*; D000698:Analgesia; D000818:Animals; D003907:Dexamethasone / Q000494:pharmacology; D004558:Electric Stimulation; D006854:Hydrocortisone / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D009292:Narcotic Antagonists / Q000494:pharmacology; D010907:Pituitary Hormones / Q000502:physiology*; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D018709:Statistics, Nonparametric; D013312:Stress, Physiological / Q000097:blood / Q000503:physiopathology*
D000305:Adrenal Cortex Hormones; D009292:Narcotic Antagonists; D010907:Pituitary Hormones; D009270:Naloxone; D003907:Dexamethasone; D006854:Hydrocortisone
Stress-vyzvannaia analgeziia. Rol' gormonov gipofizarno-adrenokortikal'noĭ sistemy.