Characteristics of blood hemostatic markers in a patient with ovarian hyperstimulation syndrome who actually developed thromboembolism.
OBJECTIVE
To investigate whether a patient with ovarian hyperstimulation syndrome (OHSS) demonstrated characteristic changes in the blood hemostatic markers before she developed thromboembolism.


METHODS
Patients with OHSS had blood drawn to determine hemostatic markers and related factors.


METHODS
Twenty-three OHSS patients, including a case complicated with thromboembolism.


METHODS
The IVF-ET program of the Department of Obstetrics and Gynecology, The University of Akita, School of Medicine.


METHODS
Blood hemostatic markers and related factors.


RESULTS
The patient with thromboembolism demonstrated marked leukocytosis and higher levels of activation in the blood markers related to fibrinolytic system, such as alpha 2 plasmin inhibitor, plasmin-alpha 2 antiplasmin complexes, and D-dimers, before the onset of this episode.


CONCLUSIONS
Marked leukocytosis and higher levels of activation of the fibrinolytic system may be the signs of imminent thromboembolism in OHSS patients.
Kodama
H
H
Department of Obstetrics and Gynecology, Akita University School of Medicine, Japan.
Fukuda
J
J
Karube
H
H
Matsui
T
T
Shimizu
Y
Y
Tanaka
T
T
D000328:Adult; D015415:Biomarkers / Q000097:blood*; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis; D005341:Fibrinolysin / Q000032:analysis / Q000378:metabolism; D005342:Fibrinolysis; D006487:Hemostasis; D006801:Humans; D007964:Leukocytosis; D016471:Ovarian Hyperstimulation Syndrome / Q000097:blood / Q000150:complications*; D010062:Ovulation Induction / Q000009:adverse effects; D013923:Thromboembolism / Q000097:blood* / Q000209:etiology; D000979:alpha-2-Antiplasmin / Q000032:analysis / Q000378:metabolism
D015415:Biomarkers; D005338:Fibrin Fibrinogen Degradation Products; D000979:alpha-2-Antiplasmin; C036309:fibrin fragment D; D005341:Fibrinolysin