title: Effect of isovolemic hemodilution with dextran and albumin on thrombus formation in artificial vessel grafts inserted into the abdominal aorta of the rabbit.
abstract: The effects of isovolemic hemodilution with dextran-70 and albumin on thrombus formation in artificial arterial grafts were investigated. A polytetrafluoroethylene graft (PTFE, length 13 mm, inner diameter 3 mm) was inserted into the abdominal aorta of rabbits. Three groups of animals were studied; 1) animals receiving isovolemic hemodilution with dextran-70 (10 ml/kg body weight), 2) animals receiving isovolemic hemodilution with albumin (10 ml/kg body weight), and 3) nonhemodiluted controls. The blood flow increased by about 70% and 60% after the hemodilution with dextran and albumin, respectively, and remained high in the hemodiluted animals, after insertion of the graft. After 2 days, the vessel graft was removed and weighed. The thrombus mass was separately weighed. The results suggest that isovolemic hemodilution with both albumin and dextran is associated with a marked increase in blood flow in the rabbit. Hemodilution with dextran also reduced the amount of thrombus formation on the inner wall of the graft.
authors.affiliation: Department of Plastic and Reconstructive Surgery, Malmö General Hospital, Sweden.
authors.forename: L
authors.initials: L
authors.lastname: Frost-Arner
authors.forename: D
authors.initials: D
authors.lastname: Bergqvist
mesh_terms: D000418:Albumins / Q000494:pharmacology*; D000818:Animals; D001012:Aorta, Abdominal; D001807:Blood Vessel Prosthesis; D003911:Dextrans / Q000494:pharmacology*; D005260:Female; D005343:Fibrinolytic Agents / Q000494:pharmacology*; D006438:Hemodilution / Q000379:methods*; D008297:Male; D011817:Rabbits; D013927:Thrombosis / Q000517:prevention & control*; D014654:Vascular Patency
chemical_list: D000418:Albumins; D003911:Dextrans; D005343:Fibrinolytic Agents