Effect of lidocaine injection of EOAE in patients with tinnitus.
In the present study, evoked otoacoustic emissions (EOAEs) were measured in 30 patients with tinnitus before and after intravenous lidocaine injection (1 mg/kg). For EOAE recordings, 1 kHz tone burst stimuli were used. Intravenous lidocaine injection resulted in suppression of tinnitus in 22 (73%) ears, and changes of EOAE amplitude (increase or decrease) in 18 (60%) ears. Of the 18 ears with EOAE amplitude changes, tinnitus disappeared or decreased in 17 (94%) ears. In 12 ears without changes of EOAE amplitude, tinnitus was suppressed in only 5 (42%). Changes in latency were not detected in any of the ears. These results indicate that there is a relationship between the effect of lidocaine in tinnitus suppression and changes in cochlear micromechanics caused by lidocaine.
Haginomori
S
S
Department of Otolaryngology, Osaka Medical College, Takatsuki, Japan.
Makimoto
K
K
Araki
M
M
Kawakami
M
M
Takahashi
H
H
D000161:Acoustic Stimulation; D000328:Adult; D000368:Aged; D000779:Anesthetics, Local / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D001301:Audiometry, Pure-Tone; D001306:Auditory Pathways; D003051:Cochlea / Q000187:drug effects* / Q000502:physiology*; D007758:Ear, Inner / Q000187:drug effects* / Q000503:physiopathology*; D004525:Efferent Pathways; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000150:complications / Q000175:diagnosis; D006801:Humans; D007275:Injections, Intravenous; D008012:Lidocaine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D014012:Tinnitus / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology*
D000779:Anesthetics, Local; D008012:Lidocaine