[Hemodynamic effect of intrathecal clonidine].
Intrathecal administration of bupivacaine and clonidine results in a significant prolongation of both motor and sensitive blocks but side effects-hypotension and bradycardia-are observed. We compared two groups of patients allocated randomly. One group received intrathecal bupivacaine-morphine and the other one received clonidine-bupivacaine-morphine. In the group which received clonidine a blood pressure decrease was observed from 2nd to 8th hour, independently from the sympathetic block and easily corrected by i.v. ephedrine. Some possible explanations are discussed. No complications due to clonidine were observed.
Rubin
L
L
Service d'Anesthésie-Réanimation chirurgicale, CHU Saint-Jacques, Besançon.
Koeberlé
P
P
Bachour
K
K
Bettinger
G
G
Barale
F
F
D000368:Aged; D000701:Analgesics, Opioid / Q000008:administration & dosage; D000775:Anesthesia, Spinal / Q000379:methods*; D000779:Anesthetics, Local / Q000008:administration & dosage; D001794:Blood Pressure / Q000187:drug effects; D002045:Bupivacaine; D003000:Clonidine / Q000008:administration & dosage* / Q000494:pharmacology; D004338:Drug Combinations; D004809:Ephedrine / Q000627:therapeutic use; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007022:Hypotension / Q000139:chemically induced / Q000188:drug therapy; D008875:Middle Aged; D009020:Morphine
D000701:Analgesics, Opioid; D000779:Anesthetics, Local; D004338:Drug Combinations; D009020:Morphine; D004809:Ephedrine; D003000:Clonidine; D002045:Bupivacaine
Retentissement hémodynamique de la clonidine intrathécale.