title: [Biological factors and resistance to antidepressive agents].
abstract: Concerning depressive disorders, biological factors remain relatively unknown. However, they might first be risk factors for depressive disorders and secondly could decrease the response to antidepressants. We studied hypothyroidism, diabetes and hypothalamic-pituitary-adrenal axis disorders. In terms of neurotransmitters, beta-adrenergic dysfunction may be involved in hypothyroidism and diabetes whereas a serotonergic dysfunction may be involved in hypothalamic-pituitary-adrenal axis disorders.
authors.affiliation: Départment de Pharmacologie, Hôpital de la Salpêtrière, Paris.
authors.forename: A J
authors.initials: AJ
authors.lastname: Puech
authors.forename: E
authors.initials: E
authors.lastname: Corruble
mesh_terms: D000818:Animals; D000928:Antidepressive Agents / Q000009:adverse effects / Q000627:therapeutic use*; D003866:Depressive Disorder / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D003920:Diabetes Mellitus / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects / Q000503:physiopathology; D007037:Hypothyroidism / Q000188:drug therapy / Q000503:physiopathology / Q000523:psychology; D019965:Neurocognitive Disorders / Q000188:drug therapy* / Q000503:physiopathology / Q000523:psychology; D010913:Pituitary-Adrenal System / Q000187:drug effects / Q000503:physiopathology; D011943:Receptors, Adrenergic, beta / Q000187:drug effects / Q000502:physiology; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
chemical_list: D000928:Antidepressive Agents; D011943:Receptors, Adrenergic, beta; D011985:Receptors, Serotonin
vernacular_title: Facteurs biologiques de résistance aux antidépresseurs.