title: Search for a gene predisposing to manic-depression on chromosome 21.
abstract: Six kindreds containing multiple cases of Manic-depressive illness (MDI) were genotyped with seven highly polymorphic microsatellite loci used in the construction of an index map for chromosome 21. The kindreds were also genotyped with a microsatellite polymorphism for PFKL, a chromosome 21 locus that has shown suggestive linkage to MDI in one pedigree [Straub et al., 1993: The American Society of Human Genetics]. Evidence of linkage was not found assuming either autosomal dominant or recessive inheritance. The nonparametric affected sib pair test did not yield significant evidence of linkage.
authors.affiliation: Department of Psychiatry, University of Utah Medical Center, Salt Lake City 84132, USA.
authors.forename: W
authors.initials: W
authors.lastname: Byerley
authors.forename: J
authors.initials: J
authors.lastname: Holik
authors.forename: M
authors.initials: M
authors.lastname: Hoff
authors.forename: H
authors.initials: H
authors.lastname: Coon
mesh_terms: D015415:Biomarkers; D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002891:Chromosomes, Human, Pair 21; D005190:Family; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D008126:Lod Score; D008297:Male
chemical_list: D015415:Biomarkers