[The reflex and direct actions of novocaine on the rhythm of the heart beats in rats in early postnatal ontogeny].
In experiments on newborn rats it was shown that heart beating frequency depended on the intensity of interoceptive afferentation. Partial shutdown of the afferentation by means of intraperitoneal injection of novocaine in the dose of 25 mg/kg of body weight caused the increase of heart beating and the more complete one at higher doses (100 mg/kg of body weight) led to its decrease. The injection of 2% novocaine (150-200 mg/kg of body weight) into the peritoneum of rat puppies on the first week of life caused the transition of bradycardia into temporary or permanent stop of heart beating. The same effect was observed for isolated atrium of rat puppies on the first week of life after the addition of 0.1% novocaine to feeding solution. This effect disappeared in older animals. It was concluded that resorptive effect of novocaine on heart structures causing the disturbance of heart automatism in newborn rats occurred along with the reflex one.
Kulaev
B S
BS
Protas
L L
LL
Bursian
A V
AV
Semenova
Iu O
IuO
D000375:Aging / Q000187:drug effects* / Q000502:physiology; D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D000831:Animals, Newborn; D016275:Atrial Function; D004305:Dose-Response Relationship, Drug; D004562:Electrocardiography / Q000187:drug effects; D006325:Heart Atria / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D011343:Procaine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012018:Reflex / Q000187:drug effects* / Q000502:physiology; D018709:Statistics, Nonparametric
D000779:Anesthetics, Local; D011343:Procaine
Reflektornoe i priamoe deĭstvie novokaina na ritm sertsebieniĭ krys v rannem postnatal'nom ontogeneze.