[Studies on production of interleukin-1 beta (IL-1 beta) and granulocyte. Macrophage-colony stimulating factor (GM-CSF) by peripheral blood monocytes from patients with Mycobacterium avium-intracellulare complex (MAC) infection].
Production of Interleukin-1 beta (IL-1 beta) and granulocyte macrophage-colony stimulating factor (GM-CSF) by peripheral blood monocytes (PBMs) from patients with Mycobacterium avium-intracellulare complex (MAC) infection was assessed and the relationship with their clinical course was analyzed. PBMs were obtained from MAC-infected patients in their active stage as well as in the inactive stage and the healthy controls. Spontaneous release of IL-1 beta by PBMs from patients in the active stage was higher than those by the cells in the inactive stage or the healthy controls. On the other hand, spontaneous GM-CSF release by PBMs from patients in the active stage was higher than the healthy controls. When PBMs were stimulated with MAC-derived purified protein derivatives (PPD-B), increased production of both IL-1 beta and GM-CSF were obtained for PBMs in their active stage. While these enhanced production upon stimulation with PPD-B related to the persistent infection with MAC, the increased IL-1 beta production correlated with the exhausted nutritional state. Both IL-1 beta and GM-CSF produced by PBMs seemed to be closely related with the clinical course of human MAC infection.
Tomoda
K
K
Second Department of Internal Medicine, Nara Medical University, Japan.
Yoneda
T
T
Tsukaguchi
K
K
Yoshikawa
M
M
Tokuyama
T
T
Fu
A
A
Okamoto
Y
Y
Fukuoka
K
K
Yamamoto
C
C
Nakaya
M
M
D000368:Aged; D000369:Aged, 80 and over; D002478:Cells, Cultured; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000096:biosynthesis*; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis*; D008875:Middle Aged; D009000:Monocytes / Q000378:metabolism*; D015270:Mycobacterium avium-intracellulare Infection / Q000378:metabolism / Q000503:physiopathology*; D009752:Nutritional Status
D007375:Interleukin-1; D016178:Granulocyte-Macrophage Colony-Stimulating Factor