Aging. Silence is golden.
A pioneering genetic analysis of aging in yeast has revealed that a protein complex known to play an essential role in transcriptional silencing at mating-type loci and telomeres also controls aging and stress resistance.
Shore
D
D
Department of Microbiology, College of Physicians & Surgeons of Columbia University, New York, New York 10032, USA.
D002455:Cell Division; D005656:Fungal Proteins / Q000235:genetics / Q000502:physiology*; D000072235:Mating Factor; D010455:Peptides / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000254:growth & development*; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D016615:Telomere; D015534:Trans-Activators / Q000235:genetics; D014158:Transcription, Genetic
D005656:Fungal Proteins; D010455:Peptides; C061573:SIR4 protein, S cerevisiae; D038281:Silent Information Regulator Proteins, Saccharomyces cerevisiae; D015534:Trans-Activators; D000072235:Mating Factor