[The effect of hirudo on proteinuria, lipid metabolism and coagulation system in the patients with chronic glomerulonephritis].
Renal biopsy was performed in 31 cases of primary glomerulonephritis and the effect of Hirudo in these patients observed. The results revealed that proteinuria decreased significantly, serum albumin increased significantly and cholesterol, triglyceride reduced significantly 4 weeks after treatment with Hirudo (P < 0.01 or P < 0.05); Fibrinogen and platelet aggregation reduced significantly (P < 0.01). However, platelet count, partial thromboplastin time, bleeding and clotting time did not change (P > 0.05); urine NAGase decreased significantly (P < 0.01). It is concluded that Hirudo may decrease proteinuria and alleviate renal parenchymal damage.
Dong
K
K
Department of Nephrology, General Hospital of Chinese PLA, Beijing.
Chen
X
X
Tang
L
L
D000818:Animals; D000925:Anticoagulants / Q000627:therapeutic use*; D005922:Glomerulonephritis, IGA / Q000188:drug therapy*; D015432:Glomerulonephritis, Membranoproliferative / Q000188:drug therapy*; D005923:Glomerulosclerosis, Focal Segmental / Q000188:drug therapy; D006801:Humans; D007865:Leeches; D050356:Lipid Metabolism; D008419:Materia Medica / Q000627:therapeutic use*; D011507:Proteinuria / Q000188:drug therapy
D000925:Anticoagulants; D008419:Materia Medica