[Fluorophotometry of changes of hemato-ocular barriers in intermediate uveitis].
OBJECTIVE
Intermediate uveitis presents a characteristic clinical picture with inflammation in the vitreous and peripheral retina. From a physiological point of view, the disease is characterised by a rupture of blood-ocular barriers. To determine the sites involved, a vitreous fluorophotometry was performed in patients with intermediate uveitis and in a group of healthy patients.


METHODS
Seventy-one patients with an intermediate uveitis were studied by vitreous fluorophotometry. Anterior chamber and posterior segment fluorophotometric findings were measured 5 and 60 minutes after injection of fluorescein. Results were compared to a group of healthy patients.


RESULTS
Vitreous fluorophotometry demonstrated abnormal leakage of fluorescein in all vitreous sectors of the patients suffering from uveitis compared with the control group (p < 0.001). In the anterior chamber, leakage of fluorescein was not significantly different between the two groups (p > 0.05).


CONCLUSIONS
Results obtained suggest that intermediate uveitis involves a generalized permeability disturbance of the posterior segment secondary to a diffuse vasculitis. However, in the anterior segment this disturbance is not found.
Baglivo
E
E
Service d'Ophtalmologie, CHU Bicêtre.
Bloch-Michel
E
E
Ducot
B
B
Offret
M
M
Offret
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D001813:Blood-Retinal Barrier; D005123:Eye / Q000503:physiopathology; D005260:Female; D015590:Fluorophotometry; D006801:Humans; D008297:Male; D008875:Middle Aged; D010539:Permeability; D015867:Uveitis, Intermediate / Q000473:pathology / Q000503:physiopathology*
Etude en fluorophotométrie de l'altération des barrières hémato-oculaires au cours de l'uvéite intermédiaire.