A potential vulnerability locus for schizophrenia on chromosome 6p24-22: evidence for genetic heterogeneity.
In 265 Irish pedigrees, with linkage analysis we find evidence for a vulnerability locus for schizophrenia in region 6p24-22. The greatest lod score, assuming locus heterogeneity, is 3.51 (P = 0.0002) with D6S296. Another test, the C test, also supported linkage, the strongest results being obtained with D6S296 (P = 0.00001), D6S274 (P = 0.004) and D6S285 (P = 0.006). Non-parametric analysis yielded suggestive, but substantially weaker, findings. This locus appears to influence the vulnerability to schizophrenia in roughly 15 to 30% of our pedigrees. Evidence for linkage was maximal using an intermediate phenotypic definition and declined when this definition was narrowed or was broadened to include other psychiatric disorders.
Straub
R E
RE
Department of Psychiatry, Medical College of Virginia, Virginia Commonwealth University, Richmond 23298, USA.
MacLean
C J
CJ
O'Neill
F A
FA
Burke
J
J
Murphy
B
B
Duke
F
F
Shinkwin
R
R
Webb
B T
BT
Zhang
J
J
Walsh
D
D
D002896:Chromosomes, Human, Pair 6; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D010375:Pedigree; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*
D005819:Genetic Markers