Immunoglobulin allotype frequencies in responders and nonresponders to the Rh(D) antigen.
Immunoglobulin allotype frequencies were determined in well characterised groups of responders (n = 160) and non-responders (n = 32) to Rh(D) antigen immunisation. Allotype frequencies in these groups were compared with frequencies in a normal control population (n = 500). No significant differences in allotype frequencies were observed between the responder and non-responder groups, or when these two groups where compared with a normal control population. These results suggest that the immunoglobulin heavy-chain genes do not influence the anti-Rh(D) immune response.
Young
N T
NT
Nuffield Department of Surgery, University of Oxford, UK.
Street
J
J
Darke
C
C
D005260:Female; D006239:Haplotypes / Q000276:immunology; D006801:Humans; D007126:Immunoglobulin Allotypes / Q000096:biosynthesis* / Q000235:genetics; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000235:genetics; D007129:Immunoglobulin Gm Allotypes / Q000096:biosynthesis / Q000235:genetics; D007518:Isoantibodies / Q000096:biosynthesis* / Q000235:genetics*; D008297:Male; D012204:Rh-Hr Blood-Group System / Q000235:genetics / Q000276:immunology*; D018029:Rho(D) Immune Globulin
D007126:Immunoglobulin Allotypes; D007074:Immunoglobulin G; D007129:Immunoglobulin Gm Allotypes; D007518:Isoantibodies; C061961:RHO(D) antibody; D012204:Rh-Hr Blood-Group System; D018029:Rho(D) Immune Globulin; C026410:Rho(D) antigen