title: Localization of MODY3 to a 5-cM region of human chromosome 12.
abstract: Maturity-onset diabetes of the young (MODY) is a heterogeneous disorder that appears to be characterized by a primary defect in insulin secretion. Mutations in an unknown locus (MODY1) on chromosome 20 and the glucokinase gene (MODY2) on chromosome 7 can cause this form of non-insulin-dependent diabetes. Recent genetic studies have identified a third locus on chromosome 12 (MODY3) that is linked to MODY in a group of French families. We have identified three families from Denmark, Germany, and the U.S. (Michigan) showing evidence of linkage with MODY3 and a family from Japan showing suggestive evidence. Analysis of key recombinants in these families localized MODY3 to a 5-cM interval between the markers D12S86 and D12S807/D12S820.
authors.affiliation: Howard Hughes Medical Institute, University of Chicago, Illinois, USA.
authors.forename: S
authors.initials: S
authors.lastname: Menzel
authors.forename: K
authors.initials: K
authors.lastname: Yamagata
authors.forename: J B
authors.initials: JB
authors.lastname: Trabb
authors.forename: J
authors.initials: J
authors.lastname: Nerup
authors.forename: M A
authors.initials: MA
authors.lastname: Permutt
authors.forename: S S
authors.initials: SS
authors.lastname: Fajans
authors.forename: R
authors.initials: R
authors.lastname: Menzel
authors.forename: N
authors.initials: N
authors.lastname: Iwasaki
authors.forename: Y
authors.initials: Y
authors.lastname: Omori
authors.forename: N J
authors.initials: NJ
authors.lastname: Cox
mesh_terms: D000328:Adult; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D003718:Denmark; D003924:Diabetes Mellitus, Type 2 / Q000235:genetics*; D008040:Genetic Linkage; D005858:Germany; D006801:Humans; D007564:Japan; D009154:Mutation; D010375:Pedigree; D010641:Phenotype; D014481:United States