[Receptors and its signal transduction pathway in the renal interstitial cells].
There are several types of renal interstitial cells, such as fibroblast, monocyte/macrophage, lymphocyte, dendritic cell, and so on. These cells in the interstitium probably modulate changes in tubular repair, including cell proliferation, cell mitosis, fibrosis, immune cell infiltration and interstitial fibrosis through a complex cytokine and/or mediator network. These factors bind to cellular receptors, and then they activate signal transduction pathways, and result in expression of several information such as cell proliferation, mitosis and so on. In this paper, we attempt to describe some receptors and its signal transduction pathway in the renal interstitial cells.
Arima
S
S
Third Department of Internal Medicine, Kumamoto University School of Medicine.
Tomita
K
K
D000818:Animals; D002455:Cell Division; D006801:Humans; D007684:Kidney Tubules / Q000166:cytology* / Q000502:physiology*; D008938:Mitosis; D011945:Receptors, Angiotensin / Q000502:physiology; D017466:Receptors, Endothelin / Q000502:physiology*; D017479:Receptors, Platelet-Derived Growth Factor / Q000502:physiology; D015398:Signal Transduction
D011945:Receptors, Angiotensin; D017466:Receptors, Endothelin; D017479:Receptors, Platelet-Derived Growth Factor