title: [Treatment of motor fluctuations in Parkinson's disease with subcutaneous injections of apomorphine].
abstract: Sixteen patients with Parkinson's disease and severe motor fluctuations were treated with subcutaneous injections of apomorphine and followed up prospectively for a year. The use of the drug improved the number of daily "off" hours by 52%, while treatment efficacy remained constant for a year without the appearance of tolerance (ANOVA with repeated measurements:p = 0.0002). No severe adverse effect or any justifying treatment discontinuance were recorded. Apomorphine proved a safe and reliable drug for the treatment of motor fluctuations.
authors.affiliation: Instituto de Investigaciones Neurológicas Raúl Carrea, FLENI, Buenos Aires.
authors.forename: M
authors.initials: M
authors.lastname: Merello
authors.forename: R
authors.initials: R
authors.lastname: Leiguarda
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001058:Apomorphine / Q000008:administration & dosage* / Q000009:adverse effects / Q000627:therapeutic use; D005500:Follow-Up Studies; D006801:Humans; D007279:Injections, Subcutaneous; D008875:Middle Aged; D009068:Movement; D010300:Parkinson Disease / Q000188:drug therapy* / Q000503:physiopathology*; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D001058:Apomorphine
vernacular_title: Tratamiento de las fluctuaciones motoras de la enfermedad de Parkinson con inyecciones subcutáneas de apomorfina.