Physiologically based pharmacokinetic and pharmacodynamic modeling in health risk assessment and characterization of hazardous substances.
Recent advances in physiologically based pharmacokinetic and pharmacodynamic (PBPK/PD) modeling have introduced novel approaches for evaluating toxicological problems. Because PBPK models are amenable to extrapolation of tissue dosimetry, they are increasingly being applied to chemical risk assessment. A comprehensive listing of PBPK/PD models for environmental chemicals developed to date is referenced. Salient applications of PBPK/PD modeling to health risk assessments and characterization of hazardous substances are illustrated with examples.
Leung
H W
HW
Union Carbide Corporation, Danbury, CT 06817, USA.
Paustenbach
D J
DJ
D000818:Animals; D015386:Hazardous Substances / Q000493:pharmacokinetics* / Q000633:toxicity*; D006801:Humans; D008956:Models, Chemical; D011634:Public Health; D018570:Risk Assessment
D015386:Hazardous Substances