title: Multiple system atrophy.
abstract: The past year has seen advances in delineating the clinical features, natural history and imaging characteristics of multiple system atrophy. The initiating pathogenetic mechanisms remain unknown. However, any aetiological or pathophysiological hypothesis must consider not only neuronal loss and gliosis but also the recently described characteristic oligodendrolial cytoplasmic inclusions.
authors.affiliation: Institute of Neurology, London, UK.
authors.forename: N
authors.initials: N
authors.lastname: Quinn
authors.forename: G
authors.initials: G
authors.lastname: Wenning
mesh_terms: D001921:Brain / Q000473:pathology / Q000503:physiopathology; D003342:Corpus Striatum / Q000473:pathology / Q000503:physiopathology*; D003937:Diagnosis, Differential; D003952:Diagnostic Imaging; D006801:Humans; D002479:Inclusion Bodies / Q000473:pathology; D009410:Nerve Degeneration / Q000502:physiology*; D009460:Neurologic Examination; D009836:Oligodendroglia / Q000473:pathology; D009849:Olivopontocerebellar Atrophies / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D012791:Shy-Drager Syndrome / Q000175:diagnosis* / Q000473:pathology / Q000503:physiopathology; D013378:Substantia Nigra / Q000473:pathology / Q000503:physiopathology*