Complement C7 M/N allotyping in infectious diseases.
The allotypes of the C7 M/N polymorphism are determined by ELISA by comparing the reaction pattern of the allospecific monoclonal antibody WU 4-15 with that of polyclonal anti-C7 IgG. In order to find disease associations of the two alleles C7*M and C7*N we tested 528 hospitalised patients, most of them suffering from infectious diseases. No significant association of either of the two C7 M/N alleles to a particular disease was found, in particular refuting the hypothesis that Lyme borreliosis may be more frequent in homozygous carriers of the hypomorphic allele C7*N.
Würzner
R
R
Institute for Hygiene, University of Innsbruck, Austria.
Sölder
B M
BM
Prodinger
W M
WM
Dierich
M P
MP
D000483:Alleles; D001424:Bacterial Infections / Q000235:genetics / Q000276:immunology*; D003184:Complement C7 / Q000032:analysis* / Q000145:classification; D006801:Humans; D011110:Polymorphism, Genetic; D014777:Virus Diseases / Q000235:genetics / Q000276:immunology*
D003184:Complement C7