title: Protracted cutaneous disorders in association with low CD4+ lymphocyte counts.
abstract: We report two patients with skin disorders usually associated with severe immunosuppression, who had low CD4+ lymphocyte counts but normal immunoglobulin levels. The patients were HIV negative, and had CD4+ lymphocyte counts just above 300/mm3, but they presented with cutaneous manifestations of profound immunodeficiency. Idiopathic CD4+ lymphocyte deficiency is a recently described syndrome which may present with dermatological disease. We discuss the symptom complex of our patients in relationship to the diagnosis of idiopathic CD4+ lymphocyte deficiency.
authors.affiliation: Department of Dermatology, University of Wales College of Medicine, Heath Park, Cardiff, U.K.
authors.forename: H A
authors.initials: HA
authors.lastname: Kurwa
authors.forename: R
authors.initials: R
authors.lastname: Marks
mesh_terms: D000328:Adult; D018791:CD4 Lymphocyte Count; D005148:Facial Dermatoses / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007153:Immunologic Deficiency Syndromes / Q000150:complications*; D008297:Male; D009894:Opportunistic Infections / Q000150:complications; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000150:complications; D012871:Skin Diseases / Q000276:immunology*; D014412:Tumor Virus Infections / Q000150:complications; D014860:Warts / Q000150:complications