title: Spastic tetraplegia as an initial manifestation of familial Alzheimer's disease.
abstract: Two sisters with familial Alzheimer's disease developed spastic gait disturbance as an initial manifestation. Their gait disturbance progressed gradually, followed by dementia a few years later. Post-mortem examination of one of the patients disclosed degeneration of the thalamus and corticospinal tract in addition to numerous senile plaques and neurofibrillary tangles in the neocortex, both of which were confirmed by immunohistochemistry. This is the first report in which clinicopathological evaluation is sufficient to establish a new variant of Alzheimer's disease presenting initially as spastic tetraplegia.
authors.affiliation: Department of Neurology, Tokyo Medical and Dental University, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Sodeyama
authors.forename: M
authors.initials: M
authors.lastname: Shimada
authors.forename: T
authors.initials: T
authors.lastname: Uchihara
authors.forename: K
authors.initials: K
authors.lastname: Yanagisawa
authors.forename: H
authors.initials: H
authors.lastname: Fujigasaki
authors.forename: K
authors.initials: K
authors.lastname: Yamaguchi
authors.forename: M
authors.initials: M
authors.lastname: Matsushita
authors.forename: M
authors.initials: M
authors.lastname: Yamada
mesh_terms: D000544:Alzheimer Disease / Q000150:complications* / Q000235:genetics / Q000473:pathology; D001921:Brain / Q000473:pathology; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009128:Muscle Spasticity / Q000209:etiology* / Q000473:pathology; D010375:Pedigree; D011782:Quadriplegia / Q000209:etiology* / Q000473:pathology