title: Block of spatial learning by mGluR agonist tADA in rats.
abstract: As demonstrated recently, mGluRs are involved in some forms of learning. We thus investigated the effect of tADA (trans-azetidine-2,4-dicarboxylic acid) applied intracerebroventricularly prior to learning a spatial alternation paradigm. Compared to controls, tADA treated animals were amnesic when tested for retention 24 hr after training. Effects of state-dependency were excluded. These data and our earlier work indicate that both mGluR agonists and antagonists can have memory-disrupting effects.
authors.affiliation: Department of Neurophysiology, Federal Institute for Neurobiology, Magdeburg, Germany.
authors.forename: G
authors.initials: G
authors.lastname: Riedel
authors.forename: W
authors.initials: W
authors.lastname: Wetzel
authors.forename: A P
authors.initials: AP
authors.lastname: Kozikowski
authors.forename: K G
authors.initials: KG
authors.lastname: Reymann
mesh_terms: D000818:Animals; D003998:Dicarboxylic Acids / Q000494:pharmacology*; D018690:Excitatory Amino Acid Agonists / Q000494:pharmacology; D007858:Learning / Q000187:drug effects*; D008297:Male; D008568:Memory; D051381:Rats; D017208:Rats, Wistar; D017470:Receptors, Glutamate / Q000187:drug effects*; D013037:Spatial Behavior / Q000187:drug effects*
chemical_list: D003998:Dicarboxylic Acids; D018690:Excitatory Amino Acid Agonists; D017470:Receptors, Glutamate