Biosynthesis of brominated tyrosine metabolites by Aplysina fistularis.
The biosynthesis of brominated tyrosine metabolites by the marine sponge Aplysina fistularis was investigated. [U-14C]-L-Tyrosine, [U-14C]-L-3-bromotyrosine, and [U-14C]-L-3,5-dibromotyrosine were incorporated into both dibromoverongiaquinol [1] and aeroplysinin-1 [2], and [methyl-14C]methionine was specifically incorporated into the O-methyl group group of 2. [Methyl-14C]-L-O-methyltyrosine, [methyl-14C]-L-3,5-dibromo-O-methyltyrosine, and several putative nitrile precursors were not incorporated into 1 or 2.
Carney
J R
JR
Roger Adams Laboratory, University of Illinois, Urbana 61801, USA.
Rinehart
K L
KL
D000818:Animals; D001966:Bromine / Q000378:metabolism*; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D002855:Chromatography, Thin Layer; D011161:Porifera / Q000378:metabolism*; D013055:Spectrophotometry, Infrared; D014443:Tyrosine / Q000096:biosynthesis*
D014443:Tyrosine; D001966:Bromine