Cardiorespiratory transfer during sleep: a study in healthy young men.
This study tested the concept that changes in breathing parameters account for modifications in respiratory-related blood pressure (BP) and R-R interval (RRI) variability during nocturnal sleep. BP (Finapres), electrocardiogram, respiration (Respitrace), and polygraphic sleep recordings were recorded continuously in 13 healthy men aged 18-37 yr. The transfer characteristics identified by coherence and gain measures between the calibrated thoraco-abdominal motion and the respiratory-related BP and RRI variability evidenced a consistent increase during transitions from wake to light sleep and from light to deep sleep but returned to waking levels during rapid-eye-movement sleep (P < 0.0001). These changes were related to the specific modifications occurring in the respiratory rate, tidal volume, and ribcage-to-abdominal motion ratio during the different sleep stages (0.28 < r < 0.39; P < 0.0001). This study demonstrates 1) that modifications in the breathing pattern account for 8-15% of the variance in the cardiorespiratory transfer, and 2) that respiratory modulation of vagal activity is not the main mechanism controlling the magnitude of the respiratory-related BP and RRI variability during sleep.
Van de Borne
P
P
Hypertension Clinic, Hôpital Erasme, Université Libre de Bruxelles, Belgium.
Biston
P
P
Paiva
M
M
Nguyen
H
H
Linkowski
P
P
Degaute
J P
JP
D000293:Adolescent; D000328:Adult; D001146:Arrhythmia, Sinus / Q000503:physiopathology; D001794:Blood Pressure; D002320:Cardiovascular Physiological Phenomena; D006339:Heart Rate; D006801:Humans; D008297:Male; D012016:Reference Values; D012119:Respiration; D012143:Respiratory Physiological Phenomena; D012890:Sleep / Q000502:physiology*