Central administration of cholecystokinin stimulates gastric pepsinogen secretion from anaesthetized rats.
Intracerebroventricular administration of CCK-8S was associated with a stimulation of gastric pepsinogen secretion from anaesthetized rats; similar effects were induced by CCK-8S given intravenously. The excitatory effect of intracerebroventricular CCK-8S was not modified by central injection of L-364,718 or L-365,260, whereas both these antagonists, given by intravenous route, prevented the pepsigogue action of parenteral CCK-8S. Intracerebroventricular or intravenous CCK-8S also increased basal acid secretion, this latter effect being prevented by parenteral L-365,260 but not L-364,718. It is suggested that centrally applied CCK-8S evokes pepsinogen secretion through the activation of peripheral CCK-A and CCK-B receptors.
Blandizzi
C
C
Institute of Medical Pharmacology, School of Medicine and Dentistry, University of Pisa, Italy.
Natale
G
G
Carignani
D
D
Colucci
R
R
Lazzeri
G
G
Del Tacca
M
M
D000758:Anesthesia; D000818:Animals; D001570:Benzodiazepinones / Q000494:pharmacology; D020109:Devazepide; D004305:Dose-Response Relationship, Drug; D007275:Injections, Intravenous; D007278:Injections, Spinal; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology*; D010435:Pepsinogens / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D011949:Receptors, Cholecystokinin / Q000187:drug effects; D012844:Sincalide / Q000031:analogs & derivatives* / Q000494:pharmacology; D013270:Stomach / Q000187:drug effects*
C090019:8-sulfocholecystokinin octapeptide; D001570:Benzodiazepinones; D018697:Nootropic Agents; D010435:Pepsinogens; D011949:Receptors, Cholecystokinin; D020109:Devazepide; D012844:Sincalide