title: Bulbar morphology and expression of bulbar dopamine and parvalbumin in experimentally-induced anosmic rats.
abstract: Morphological study was carried out in rats with olfactory dysfunction induced by deafferentation of serotonergic fibers in the olfactory bulb. With a computer capable of area measurements, olfactory bulbs of the anosmic rats were found to be decreased in size to 61% of control bulbs, and all bulbar layers were involved in the bulbar shrinkage. Given areas of each bulbar layer in control bulbs to be 100%, percentages of each bulbar layer in the anosmic rats were 23% in the olfactory nerve layer, 54% in the glomerular layer, 63% in the external plexiform layer, 83% in the internal plexiform layer and 81% in the granule cell layer. Dopamine-and parvalbumin-containing neurons were examined immunohistochemically in the experimentally-induced anosmic rats. As a result, immunoreactive neurons for these two chemical substances were significantly decreased in number (dopamine, 33% of control value; parvalbumin, 46% of control value). The present study, using an animal model of anosmia, provided quantitative data on the bulbar atrophy and showed effects of anosmia on expression of dopamine and parvalbumin in the bulb.
authors.affiliation: Department of Otorhinolaryngology, Kanazawa University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tsukatani
authors.forename: M
authors.initials: M
authors.lastname: Furukawa
authors.forename: M
authors.initials: M
authors.lastname: Moriya
authors.forename: S
authors.initials: S
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Okoyama
authors.forename: T
authors.initials: T
authors.lastname: Moriizumi
mesh_terms: D000818:Animals; D004298:Dopamine / Q000502:physiology*; D007150:Immunohistochemistry; D009474:Neurons / Q000648:ultrastructure; D000857:Olfaction Disorders / Q000503:physiopathology*; D009830:Olfactory Bulb / Q000503:physiopathology* / Q000648:ultrastructure*; D009832:Olfactory Nerve; D010320:Parvalbumins / Q000648:ultrastructure*; D051381:Rats; D012903:Smell; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
chemical_list: D010320:Parvalbumins; D014446:Tyrosine 3-Monooxygenase; D004298:Dopamine