Selection of women at high risk of breast cancer using two lifestyle markers: a case control study.
OBJECTIVE
To select a population of women with high risk of invasive breast cancer by using two markers of high risk lifestyle--age at first delivery > = 25 and daily alcohol intake > = 7 g.


METHODS
Case control study based on a structural interview.


METHODS
Two general practices in Copenhagen, Denmark.


METHODS
30 patients with invasive breast cancer and 30 age-matched controls.


METHODS
The combined selection power of the two markers of high risk lifestyle.


RESULTS
The combined selection power of the two markers was significant (P < 0.025, odds ratio 4.3, 95% CI 1.2-15.6).


CONCLUSIONS
Using these markers it may be possible to select about 80% of all cases of invasive breast cancer in a high risk group comprising only 49% of the female population. This could be of importance for mammography screening; rather than unselectively screening all women in a given age bracket, it might be preferable selectively to screen only the high risk group.
Erichsen
G G
GG
Søegaard
N E
NE
D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000428:Alcohol Drinking; D001943:Breast Neoplasms / Q000453:epidemiology; D016022:Case-Control Studies; D015984:Causality; D016009:Chi-Square Distribution; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008019:Life Style; D008875:Middle Aged; D011247:Pregnancy