[The effect of pyrimidines, levamisole and prodigiozan on the antigen-specific regulation of delayed hypersensitivity in relation to the age and strain of the mice].
The effect of pyrimidine, levamizol, and prodigiozan on the retarded hypersensitivity (RH) was studied on a model of adoptive transfer of the splenocytes from donors of different ages to young syngeneic recipients. Splenocytes from CBA and BALB/c suckers, receiving pyrimidine, activate the RH suppression. Levamizol and prodigiozan exert the same effect on BALB/c mice and inhibit the RH suppression in CBA mice. In mature CBA mice these preparations potentiate HST. The splenocytes from young and aged BALB/c donors receiving the preparations oppositely induce the RH recipients.
Gaĭnutdinova
D T
DT
Lazareva
D N
DN
Speranskiĭ
V V
VV
D000375:Aging / Q000187:drug effects* / Q000276:immunology; D000818:Animals; D000833:Animals, Suckling; D000939:Epitopes / Q000187:drug effects* / Q000276:immunology; D005260:Female; D006968:Hypersensitivity, Delayed / Q000276:immunology*; D007116:Immunization, Passive / Q000379:methods; D007978:Levamisole / Q000494:pharmacology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D011354:Prodigiozan / Q000494:pharmacology*; D011743:Pyrimidines / Q000494:pharmacology*; D013154:Spleen / Q000276:immunology / Q000637:transplantation; D050378:T-Lymphocytes, Regulatory / Q000187:drug effects / Q000276:immunology; D014185:Transplantation, Isogeneic
D000939:Epitopes; D011743:Pyrimidines; D007978:Levamisole; D011354:Prodigiozan
Vliianie pririmidinov, levamizola i prodigiozana na antigenspetsificheskuiu reguliatsiiu giperchuvstvitel'nosti zamedlennogo tipa v zavisimosti ot vozrasta i linii mysheĭ.