Radiation recall dermatitis induced by edatrexate in a patient with breast cancer.
Enhancement of radiation injury to the skin and mucous membranes has been observed with a number of chemotherapeutic agents. A 32-year-old woman with metastatic breast cancer received local radiation therapy to the lumbosacral area. Six weeks later, systemic edatrexate therapy was initiated and a localized painful erythema with edema and a vesicular eruption occurred over the previous site of radiation therapy. Physicians should be aware that edatrexate can cause radiation recall, and that careful use of anti-inflammatory agents may allow continued chemotherapy treatment.
Perez
E A
EA
Division of Hematology/Oncology, University of California, Davis, Sacramento, USA.
Campbell
D L
DL
Ryu
J K
JK
D000328:Adult; D000630:Aminopterin / Q000009:adverse effects / Q000031:analogs & derivatives*; D000970:Antineoplastic Agents / Q000009:adverse effects*; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000532:radiotherapy*; D018270:Carcinoma, Ductal, Breast / Q000188:drug therapy* / Q000532:radiotherapy*; D003131:Combined Modality Therapy; D003875:Drug Eruptions / Q000209:etiology*; D005260:Female; D006801:Humans; D011855:Radiodermatitis / Q000209:etiology*
D000970:Antineoplastic Agents; C040210:edatrexate; D000630:Aminopterin