Fatal necrotizing pancreatitis caused by hepatitis B virus infection in a liver transplant recipient.
A 32-year-old man who had undergone liver transplantation for fulminant hepatitis due to HBV infection developed fatal acute necrotizing pancreatitis on the 60th post-transplant day, while showing signs of intense viral replication. Immunohistochemistry and in situ hybridization of the pancreas following autopsy showed the presence of HBsAG and HBV-DNA in the cytoplasm of acinar cells, together with the picture of necrotizing pancreatitis. Clinical and histological features seem to indicate that pancreatitis was directly caused by HBV infection.
Cavallari
A
A
Second Department of Surgery, University of Bologna, S. Orsola Hospital, Italy.
Vivarelli
M
M
D'Errico
A
A
Bellusci
R
R
Scarani
P
P
DeRaffele
E
E
Nardo
B
B
Gozzetti
G
G
D000208:Acute Disease; D000328:Adult; D017809:Fatal Outcome; D006509:Hepatitis B / Q000150:complications* / Q000175:diagnosis / Q000378:metabolism / Q000628:therapy / Q000821:virology; D006801:Humans; D016031:Liver Transplantation / Q000000981:diagnostic imaging / Q000473:pathology*; D008297:Male; D009336:Necrosis; D010195:Pancreatitis / Q000175:diagnosis / Q000209:etiology* / Q000378:metabolism / Q000628:therapy; D011859:Radiography