title: [Clinical and experimental study on codonopsis pilosula oral liquor in treating coronary heart disease with blood stasis].
abstract: The effects of Codonopsis pilosula oral liquor (CPOL) on tissue-type plasminogen activator (t-PA) and plasminogen activator inhibitor (PAI) in the plasma of 25 patients of coronary heart disease with blood stasis were studied. It has been shown that those patients had a significant decrease in t-PA activity (P < 0.01) compared to healthy subjects. After 4 weeks of CPOL therapy, platelet aggregation significantly decreased (P < 0.05), there was no significant difference in t-PA and PAI. From the results shown above, it suggested that one of the effects of CPOL in influencing blood coagulation was its inhibition on platelet aggregation, but not through the elevating of fibrinolytic activity.
authors.affiliation: Dongzhimen Hospital, Beijing University of TCM.
authors.forename: X
authors.initials: X
authors.lastname: Xu
authors.forename: S R
authors.initials: SR
authors.lastname: Wang
authors.forename: Q
authors.initials: Q
authors.lastname: Lin
mesh_terms: D000328:Adult; D000368:Aged; D003327:Coronary Disease / Q000097:blood* / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D015849:Plasminogen Inactivators / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D010959:Tissue Plasminogen Activator / Q000097:blood; D016710:Yin Deficiency / Q000097:blood / Q000188:drug therapy
chemical_list: D004365:Drugs, Chinese Herbal; D015849:Plasminogen Inactivators; D010975:Platelet Aggregation Inhibitors; D010959:Tissue Plasminogen Activator