Alcohol modulation of immune function: clinical and experimental data. Veterans Affairs Cooperative Study Groups 119 and 275.
In both animal and human studies, ethanol seems to modulate host immune function. In a variety of animal studies, ethanol has been shown to decrease lymphocyte function and number. In human studies of patients with alcoholic hepatitis, these abnormalities were also seen with specific correlation with protein malnutrition. Hepatic pathological lesions were also correlated with lymphocyte subset infiltration. However, peripheral blood lymphocytes did not correlate consistently with hepatic histopathology.
Roselle
G A
GA
Department of Veterans Affairs Medical Center, Cincinnati, Ohio 45220, USA.
Mendenhall
C L
CL
Chedid
A
A
Moritz
T E
TE
Gartside
P
P
D000818:Animals; D003131:Combined Modality Therapy; D005500:Follow-Up Studies; D005527:Food, Fortified; D006519:Hepatitis, Alcoholic / Q000188:drug therapy / Q000276:immunology* / Q000401:mortality; D006801:Humans; D008099:Liver / Q000187:drug effects / Q000276:immunology / Q000473:pathology; D018655:Lymphocyte Count / Q000187:drug effects; D010074:Oxandrolone / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage; D015996:Survival Rate; D016176:T-Lymphocyte Subsets / Q000187:drug effects / Q000276:immunology*
D010074:Oxandrolone; D011239:Prednisolone