title: Ferrochelatase binds the iron-responsive element present in the erythroid 5-aminolevulinate synthase mRNA.
abstract: Ferrochelatase, the terminal enzyme of the heme biosynthetic pathway, binds an iron-responsive element (IRE) present in the 5'untranslated region of the mRNA for erythroid 5-aminolevulinate synthase, the first enzyme of the heme biosynthetic pathway. This IRE-binding activity of ferrochelatase may play a critical role in the regulation of heme biosynthesis in differentiating erythrocytes.
authors.affiliation: Department of Biochemistry and Molecular Biology, College of Medicine, University of South Florida, Tampa 33612, USA.
authors.forename: G C
authors.initials: GC
authors.lastname: Ferreira
mesh_terms: D000624:5-Aminolevulinate Synthetase / Q000096:biosynthesis*; D000818:Animals; D001665:Binding Sites; D015252:Deoxyribonucleases, Type II Site-Specific; D004912:Erythrocytes / Q000201:enzymology*; D005294:Ferrochelatase / Q000302:isolation & purification / Q000378:metabolism*; D007501:Iron / Q000378:metabolism; D007527:Isoenzymes / Q000096:biosynthesis; D051379:Mice; D012333:RNA, Messenger / Q000378:metabolism*; D011994:Recombinant Proteins / Q000302:isolation & purification / Q000378:metabolism*; D015183:Restriction Mapping
chemical_list: D007527:Isoenzymes; D012333:RNA, Messenger; D011994:Recombinant Proteins; D007501:Iron; D000624:5-Aminolevulinate Synthetase; D015252:Deoxyribonucleases, Type II Site-Specific; C038565:GCGGCCGC-specific type II deoxyribonucleases; C029792:GTCGAC-specific type II deoxyribonucleases; D005294:Ferrochelatase