Hypersensitivity to cefuroxime with good tolerance to other betalactams.
A 60-year-old man developed an anaphylactic reaction immediately after administration of intramuscular sodium cefuroxime. By means of oral controlled challenge, the reaction was reproduced with a smaller dose of cefuroxime axetil. Cross-reactivity with other betalactam antibiotics was ruled out by in vivo tests. This case supports once again the relevance of the side-chain in betalactam allergy.
Marcos Bravo
C
C
Servicio Alergología, Hospital Xeral-Cíes, Vigo, Pontevedral, Spain.
Luna Ortiz
I
I
González Vázquez
R
R
D000900:Anti-Bacterial Agents / Q000009:adverse effects / Q000494:pharmacology*; D002444:Cefuroxime / Q000009:adverse effects*; D003429:Cross Reactions; D004342:Drug Hypersensitivity / Q000209:etiology*; D004361:Drug Tolerance; D006801:Humans; D008297:Male; D008875:Middle Aged; D010919:Placebos; D016037:Single-Blind Method
D000900:Anti-Bacterial Agents; D010919:Placebos; D002444:Cefuroxime