title: [Disorders of eye movement in amyotrophic lateral sclerosis--report of 2 patients].
abstract: BACKGROUND
  Amyotrophic lateral sclerosis (ALS), a neurodegenerative disorder of unknown origin, was thought to spare the extraocular muscles. Extraocular involvement has recently been reported to occur in the late stages of ALS following respiratory insufficiency.
  
  
  METHODS
  We report on two patients with ALS who were referred for screening of oculomotor impairment in ALS. Orthoptic examination in a 64-year-old woman with peripheral ALS revealed retraction of the upper eye lids as well as impaired abduction and upgaze in both eyes, developing prior to respiratory insufficiency. A 50-year-old man with bulbar ALS was found to have bilateral impairment of upgaze as well as a negative Bell's phenomenon. Horizontal pursuit was interrupted by compensatory saccades, vertical fixating saccades were slightly hypometric. These oculomotor changes were also seen prior to respiratory insufficiency.
  
  
  CONCLUSIONS
  These findings provide further evidence of early oculomotor involvement in ALS, e.g. prior to respiratory failure and prior than previously suspected. Oculomotor impairment may occur in both the peripheral and the bulbar type of ALS.
authors.affiliation: Augenklinik und Poliklinik, Universität des Saarlandes Homburg.
authors.forename: A
authors.initials: A
authors.lastname: Palmowski
authors.forename: W H
authors.initials: WH
authors.lastname: Jost
authors.forename: J
authors.initials: J
authors.lastname: Osterhage
authors.forename: J
authors.initials: J
authors.lastname: Prudlo
authors.forename: B
authors.initials: B
authors.lastname: Käsmann
authors.forename: K
authors.initials: K
authors.lastname: Schimrigk
authors.forename: K W
authors.initials: KW
authors.lastname: Ruprecht
mesh_terms: D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009760:Nystagmus, Physiologic / Q000502:physiology; D015835:Ocular Motility Disorders / Q000175:diagnosis* / Q000503:physiopathology; D009801:Oculomotor Muscles / Q000503:physiopathology; D011698:Pursuit, Smooth / Q000502:physiology; D012438:Saccades / Q000502:physiology