title: Increased incidence of neurofibrillary tangles (NFT) in non-demented individuals with hypertension.
abstract: The incidence rates and numerical densities of argryophilic neurofibrillary tangles (NFT) and senile plaques (SP) were determined in non-demented individuals and subjects with Alzheimer's disease (AD). The non-AD subjects were grouped according to cardiac status; those individuals with critical coronary artery disease (cCAD), those hypertensive individuals without cCAD (HyperT), and those without heart disease (non-HD). The incidence and densities of SP and NFT were significantly greater in AD than any of the non-demented groups. The prevalence of SP was increased in both HyperT and cCAD compared to non-HD controls, while NFT occurrence was accentuated in non-demented HyperT subjects only. The densities of SP and NFT in HyperT were elevated compared to cCAD or both cCAD and non-HD controls; NFT densities were similar in cCAD and non-HD. NFT density increased with increasing age in only the non-HD and cCAD groups, suggesting a possible relationship between disease process and NFT formation in the AD and HyperT populations.
authors.affiliation: Sanders-Brown Center on Aging, University of Kentucky Medical Center, Lexington, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Sparks
authors.forename: S W
authors.initials: SW
authors.lastname: Scheff
authors.forename: H
authors.initials: H
authors.lastname: Liu
authors.forename: T M
authors.initials: TM
authors.lastname: Landers
authors.forename: C M
authors.initials: CM
authors.lastname: Coyne
authors.forename: J C
authors.initials: JC
authors.lastname: Hunsaker
mesh_terms: D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000544:Alzheimer Disease / Q000473:pathology; D000911:Antibodies, Monoclonal; D015415:Biomarkers; D003327:Coronary Disease / Q000473:pathology; D003704:Dementia / Q000150:complications / Q000473:pathology; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000453:epidemiology / Q000473:pathology*; D007150:Immunohistochemistry; D015994:Incidence; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000473:pathology*
chemical_list: D000911:Antibodies, Monoclonal; D015415:Biomarkers; C085349:PHF-1 monoclonal antibody