title: [Granuloma anulare disseminatum as a rare side effect of allopurinol].
abstract: During long-term therapy of hyperuricaemia with allopurinol (300 mg/d) two patients developed generalized granuloma annulare. The diagnoses were confirmed by histology; concomitant diseases, especially diabetes mellitus, were not detectable. Following discontinuation of allopurinol therapy, cutaneous granulomas healed without relapse. Hyperuricaemia could be controlled by low-purine diet and medication avoiding allopurinol. The clinical history of our two patients suggested a causal connection between allopurinol therapy and generalized granuloma annulare. For this reason we rate the development of this disease in both cases as a rare but significant side effect of allopurinol. This should give rise to critical assessment of concomitant drug therapy during development of generalized granuloma annulare.
authors.affiliation: Hautklinik, Johannes Gutenberg-Universität, Mainz.
authors.forename: D
authors.initials: D
authors.lastname: Becker
authors.forename: A
authors.initials: A
authors.lastname: Enk
authors.forename: W
authors.initials: W
authors.lastname: Bräuninger
authors.forename: J
authors.initials: J
authors.lastname: Knop
mesh_terms: D000368:Aged; D000493:Allopurinol / Q000009:adverse effects* / Q000627:therapeutic use; D001706:Biopsy; D003875:Drug Eruptions / Q000175:diagnosis* / Q000473:pathology; D005260:Female; D006073:Gout / Q000188:drug therapy*; D016460:Granuloma Annulare / Q000139:chemically induced* / Q000473:pathology; D006801:Humans; D008134:Long-Term Care; D008297:Male; D008875:Middle Aged; D012867:Skin / Q000473:pathology
chemical_list: D000493:Allopurinol