Glycoside-bearing liposomal delivery systems against macrophage-associated disorders involving Mycobacterium leprae and Mycobacterium tuberculosis.
Asiaticoside, a plant glycoside with rhamnose as end sugar and having microbicidal properties was tested against Mycobacterium leprae and Mycobacterium tuberculosis both in vivo and in vitro. As rhamnose is reported to have no tissue specificity, corchorusin D having glucose as end sugar was used for targeting with an equimolar proportion of asiaticoside in liposomal form for testing the drug value. Results showed that liposomal asiaticoside had better microbicidal property against M. leprae and M. tuberculosis when compared to that of free asiaticoside whereas liposomes containing asiaticoside and corchorusin D were found to be equally or more active in comparison to liposomal asiaticoside alone. It is inferred that appropriate glycosides, if used in liposomal form (incorporated or covalently grafted) have enhanced drug efficacy and such glycoside bearing liposomes as targeted delivery systems could be used for chemotherapeutic control of several other diseases.
Medda
S
S
Biomembrane Division, Indian Institute of Chemical Biology, Jadavpur, Calcutta.
Das
N
N
Mahato
S B
SB
Mahadevan
P R
PR
Basu
M K
MK
D000818:Animals; D004337:Drug Carriers; D005260:Female; D007918:Leprosy / Q000188:drug therapy*; D008081:Liposomes; D008264:Macrophages / Q000187:drug effects*; D008297:Male; D051379:Mice; D009166:Mycobacterium leprae; D009169:Mycobacterium tuberculosis; D014315:Triterpenes / Q000008:administration & dosage*; D014376:Tuberculosis / Q000188:drug therapy*
D004337:Drug Carriers; D008081:Liposomes; D014315:Triterpenes; C004446:asiaticoside