Molecular heterogeneity of G-6-PD deficiency in Mexico.
DNA samples from seven G-6-PD deficient Mexican mestizo patients were analyzed. Three different G-6-PD genotypes were observed: G-6-PD A-202A/376G (three patients), G-6-PD A-376G/968C (three patients) and G-6-PD Seattle844C. The present results, along with previous reports, suggest not only G-6-PD A-genotypes are relatively common but also G-6-PD deficiency seems to be heterogeneous at DNA level in Mexico.
Medina
M D
MD
Division de Genética, IMSS, Guadalajara, Jal., México.
Vaca
G
G
Esparza
A
A
Westwood
B
B
Beutler
E
E
D000349:Africa / Q000208:ethnology; D004252:DNA Mutational Analysis; D005820:Genetic Testing; D005838:Genotype; D005954:Glucosephosphate Dehydrogenase / Q000235:genetics*; D005955:Glucosephosphate Dehydrogenase Deficiency / Q000453:epidemiology / Q000208:ethnology / Q000235:genetics*; D006801:Humans; D007558:Italy / Q000208:ethnology; D008297:Male; D008800:Mexico / Q000453:epidemiology; D013030:Spain / Q000208:ethnology
D005954:Glucosephosphate Dehydrogenase