title: [Effect of Bacillus natto-fermented product (BIOZYME) on blood alcohol, aldehyde concentrations after whisky drinking in human volunteers, and acute toxicity of acetaldehyde in mice].
abstract: Effects of Bacillus natto-fermented product (BIOZYME) on blood alcohol and aldehyde concentrations after drinking whisky (corresponding to 30-65 ml ethanol) were studied in 21 healthy volunteers. When 100 ml of BIOZYME was orally administrated to the volunteers before drinking whisky, the time delay of both blood factors to attain maximum concentrations were observed. The maximum decrease in blood alcohol and aldehyde concentrations were about 23% and 45% (p < 0.005), respectively, at 1 hr after drinking whisky. The aldehyde lowering effect of BIOZYME was continued for at least 4 hr after whisky drinking. Concentration of the breath alcohol was also sharply decreased by BIOZYME administration. The breath alcohol concentration in the administered group (0.18 +/- 0.11 mg/l) was found to be lowered about 44% than that of the control group (0.32 +/- 0.11 mg/l) (p < 0.0005, n = 21), at 1 hr after drinking whisky. In acute toxicity experiments of aldehyde in mice (12 mmol AcH/mg), BIOZYME showed the survival effect as with alpha-D-Ala (134% increase of the living, at 40 min after i.p. administration) (p < 0.005, n = 22). These findings reveal the Bacillus natto produced BIOZYME as a reasonable, safety and useful anti-hangover agent.
authors.affiliation: Department of Nutritional Science, Faculty of Health and Welfare Science, Okayama Prefectural University, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sumi
authors.forename: C
authors.initials: C
authors.lastname: Yatagai
authors.forename: H
authors.initials: H
authors.lastname: Wada
authors.forename: E
authors.initials: E
authors.lastname: Yoshida
authors.forename: M
authors.initials: M
authors.lastname: Maruyama
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000378:metabolism*; D000434:Alcoholic Beverages; D000447:Aldehydes / Q000097:blood* / Q000633:toxicity*; D000818:Animals; D001412:Bacillus subtilis; D000431:Ethanol / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D005285:Fermentation; D006801:Humans; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains
chemical_list: D000447:Aldehydes; D000431:Ethanol