title: Failure of osseointegrated dental implants after diphosphonate therapy for osteoporosis: a case report.
abstract: Late loss of initially integrated endosseous implants has generally been attributed to implant overload often the result of inappropriate prosthesis design. Implant placement is rarely contraindicated by preexisting systemic diseases, and no instances of medication-induced implant failure have been reported in the literature. This paper reports a case in which a patient lost five endosseous implants that had successfully osseointegrated and had been restored with a lower hybrid prosthesis approximately 6 months after diphosphonate therapy for osteoporosis was started.
authors.affiliation: Department of Oral and Maxillofacial Surgery, John Peter Smith Hospital, Fort Worth, Texas 76104, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Starck
authors.forename: B N
authors.initials: BN
authors.lastname: Epker
mesh_terms: D000368:Aged; D001732:Bite Force; D016723:Bone Remodeling / Q000187:drug effects; D003758:Dental Implantation, Endosseous; D015921:Dental Implants; D003781:Denture Retention; D004038:Diet, Reducing / Q000009:adverse effects; D012968:Etidronic Acid / Q000009:adverse effects*; D005260:Female; D006801:Humans; D009119:Muscle Contraction; D016348:Osseointegration / Q000187:drug effects*; D010018:Osteomalacia / Q000139:chemically induced* / Q000150:complications; D015663:Osteoporosis, Postmenopausal / Q000188:drug therapy; D011475:Prosthesis Failure; D015431:Weight Loss
chemical_list: D015921:Dental Implants; D012968:Etidronic Acid