The rationale for using logarithmic transformation of concentration data in toxicokinetic studies.
The present paper focuses on the necessity of logarithmic transformation of plasma concentration in toxicokinetic studies. The dose-plasma concentration relationship is the most important subject to be studied, because test doses rise over a wide range from therapeutic dose level to toxic dose level in toxicity studies. It is concluded that the logarithmic transformation of concentration data effectively stabilized the variances, and the regression analysis of log-transformed data makes it possible to quantitatively evaluate the magnitude of non-linear kinetics of test compounds in toxicity studies.
Igarashi
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Department of R&D Information Management, Eisai Co., Ltd., Tokyo, Japan.
D000704:Analysis of Variance; D000818:Animals; D001774:Blood Chemical Analysis; D003627:Data Interpretation, Statistical; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D010599:Pharmacokinetics; D012044:Regression Analysis; D018675:Toxicity Tests / Q000706:statistics & numerical data*