title: Joint space measurement in hand radiographs using computerized image analysis.
abstract: OBJECTIVE
  To compare computerized joint space (JS) measurements with conventional joint space narrowing (JSN) scores in patients with mild rheumatoid arthritis.
  
  
  METHODS
  Serial paired hand and wrist radiographs from 34 patients with classic rheumatoid arthritis were evaluated. Purpose-written software automatically measured the JS on test images and standard clinical hand radiographs; JSN was scored "blind" by 6 observers.
  
  
  RESULTS
  The software proved reliable. JS values differed significantly (men > women; metacarpophalangeal > proximal interphalangeal joints), declining with disease duration more than with age; JSN scores correlated poorly and varied more.
  
  
  CONCLUSIONS
  Computerization permits sensitive JS measurement and should be of benefit in studies of early joint disease.
authors.affiliation: SmithKline Beecham Pharmaceuticals, Harlow, Essex, UK.
authors.forename: M F
authors.initials: MF
authors.lastname: James
authors.forename: G
authors.initials: G
authors.lastname: Heald
authors.forename: J H
authors.initials: JH
authors.lastname: Shorter
authors.forename: R A
authors.initials: RA
authors.lastname: Turner
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000473:pathology; D001172:Arthritis, Rheumatoid / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000473:pathology; D001241:Aspirin / Q000627:therapeutic use; D005260:Female; D005279:Fenoprofen / Q000627:therapeutic use; D005384:Finger Joint / Q000000981:diagnostic imaging* / Q000473:pathology*; D006225:Hand / Q000000981:diagnostic imaging*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000592:standards*; D008297:Male; D008662:Metacarpophalangeal Joint / Q000000981:diagnostic imaging / Q000473:pathology; D008875:Middle Aged; D009288:Naproxen / Q000627:therapeutic use; D011859:Radiography; D012984:Software
chemical_list: D009288:Naproxen; D001241:Aspirin; D005279:Fenoprofen