The effects of thiopentone and propofol on delayed hypersensitivity reactions.
The effects of thiopentone and propofol on delayed hypersensitivity reactions and T lymphocyte proliferation were studied in nine healthy volunteers (five women and four men). Thiopentone 5 mg.kg-1 and propofol 2.5 mg kg-1 were given as a 10 min infusion on two separate occasions. The volunteers were exposed to a skin multitest antigen before and after administration of the two agents and their skin reactions assessed. T lymphocyte responses were studied using phytohaemagglutinin (PHA)-induced proliferation. Results showed that both drugs caused a significant depression of skin reactions in vivo but no depression in the T lymphocyte proliferation.
Devlin
E G
EG
Department of Anaesthetics, Queen's University of Belfast.
Clarke
R S
RS
Mirakhur
R K
RK
McNeill
T A
TA
D000328:Adult; D002455:Cell Division / Q000187:drug effects; D017449:Dermatitis, Allergic Contact / Q000276:immunology*; D005260:Female; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects*; D007111:Immunity, Cellular / Q000187:drug effects; D007428:Intradermal Tests; D008297:Male; D010835:Phytohemagglutinins / Q000276:immunology; D015742:Propofol / Q000494:pharmacology*; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013874:Thiopental / Q000494:pharmacology*
D010835:Phytohemagglutinins; D013874:Thiopental; D015742:Propofol