title: Lichen planus induced by interferon-alpha-2a therapy for chronic active hepatitis C.
abstract: OBJECTIVE
  To report the development of hepatitis C virus (HCV)-positive chronic active hepatitis with lichen planus in a patient during interferon treatment.
  
  
  METHODS
  Case report and literature review.
  
  
  METHODS
  A 64-year-old anti-HCV and HCV-RNA-positive woman.
  
  
  METHODS
  The patient received interferon-alpha-2a treatment for histologically proven chronic active hepatitis.
  
  
  RESULTS
  Four months after the start of treatment the patient developed multiple cutaneous lesions on her hands, feet and back. A skin biopsy led to the diagnosis of lichen planus. The withdrawal of interferon was followed by a marked improvement in the cutaneous lesions, but not complete regression.
  
  
  CONCLUSIONS
  This case shows that HCV-positive patients with chronic active hepatitis may develop lichen planus during interferon therapy.
authors.affiliation: Department of Internal Medicine, University of Genova, Italy.
authors.forename: T
authors.initials: T
authors.lastname: Barreca
authors.forename: G
authors.initials: G
authors.lastname: Corsini
authors.forename: R
authors.initials: R
authors.lastname: Franceschini
authors.forename: C
authors.initials: C
authors.lastname: Gambini
authors.forename: A
authors.initials: A
authors.lastname: Garibaldi
authors.forename: E
authors.initials: E
authors.lastname: Rolandi
mesh_terms: D005260:Female; D006526:Hepatitis C / Q000628:therapy*; D006521:Hepatitis, Chronic / Q000628:therapy*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000009:adverse effects*; D008010:Lichen Planus / Q000209:etiology*; D008875:Middle Aged; D011994:Recombinant Proteins
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins