Molecular biologic and pathogenetic analysis of hepatitis delta virus.
Hepatitis delta virus (HDV) consists of an envelope derived from hepatitis B virus (HBV) and a nucleocapsid consisting of hepatitis delta antigen and a circular RNA genome. Both the delta antigen and the RNA possess many unique properties which play crucial roles in the life cycle of HDV. They may also contribute indirectly to the mechanism of viral pathogenesis.
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Howard Hughes Medical Institute, University of Southern California, School of Medicine, Los Angeles 90033, USA.
D000956:Antigens, Viral / Q000302:isolation & purification*; D002213:Capsid / Q000302:isolation & purification*; D003001:Cloning, Molecular; D006515:Hepatitis B virus / Q000502:physiology; D003698:Hepatitis Delta Virus / Q000235:genetics* / Q000472:pathogenicity; D035923:Hepatitis delta Antigens; D006801:Humans; D012367:RNA, Viral / Q000096:biosynthesis / Q000302:isolation & purification*; D014759:Viral Envelope Proteins / Q000302:isolation & purification*
D000956:Antigens, Viral; D035923:Hepatitis delta Antigens; D012367:RNA, Viral; D014759:Viral Envelope Proteins; C442244:hepatitis delta virus large antigen