title: Cyclin A links c-Myc to adhesion-independent cell proliferation.
abstract: Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat 1a fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c-Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.
authors.affiliation: Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Barrett
authors.forename: B C
authors.initials: BC
authors.lastname: Lewis
authors.forename: A T
authors.initials: AT
authors.lastname: Hoang
authors.forename: R J
authors.initials: RJ
authors.lastname: Alvarez
authors.forename: C V
authors.initials: CV
authors.lastname: Dang
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D016213:Cyclins / Q000235:genetics / Q000378:metabolism*; D005347:Fibroblasts; D005786:Gene Expression Regulation; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011994:Recombinant Proteins / Q000378:metabolism
chemical_list: D016213:Cyclins; D016271:Proto-Oncogene Proteins c-myc; D011994:Recombinant Proteins