BF phenotype distribution in five populations of Spain: anthropological considerations.
The genetic polymorphism of the human Properdin Factor B (BF) in five populations of the Iberian Peninsula (Galicia, Castilla-Leon, Castilla-La Mancha, Extremadura and Western Andalusia) was analysed by means of Isoelectric Focusing in polyacrylamide gels followed by Immunofixation-Silver Staining. Statistical analysis of heterogeneity showed significant differences in the distribution of BF allele frequencies among the Iberian populations so far examined. The high allele frequencies obtained for BF*F and BF*F1 give support to the allelocline distribution hypothesis in the European continent (regression analysis between allele frequency and latitude: r = -0.6237 and r+ -0.8058, for BF*F1 and BF*F respectively).
Caeiro
J L
JL
Departamento de Antropoloxia, Facultade de Bioloxia, Santiago de Compostela, Galicia, Spain.
Parra
E
E
Gremo
A
A
Teixeira
C
C
Llano
C
C
D000483:Alleles; D011415:Complement Factor B / Q000235:genetics*; D004591:Electrophoresis, Polyacrylamide Gel; D005787:Gene Frequency; D018740:Genetic Heterogeneity; D006801:Humans; D007525:Isoelectric Focusing; D010641:Phenotype; D011110:Polymorphism, Genetic; D044469:Racial Groups / Q000235:genetics*; D012044:Regression Analysis; D013030:Spain; D044465:White People / Q000235:genetics
D011415:Complement Factor B