title: The instability of dietary iodine supply over time in an affluent society.
abstract: In the Bernese region, where goiter was formerly endemic, alimentary salt has been supplemented by increasing amounts of potassium iodide (KI): 5, 10, 20 mg KI/kg in 1922, 1965 and 1980 respectively. Ioduria rose from < 30 micrograms I/g creatinine in 1920 to > 100 micrograms I/g creatinine in the 1980s. In 1992 ioduria was estimated in 55 healthy volunteers (group A and individual B) and 234 thyroid carcinoma patients after thyroidectomy: hypothyroid patients with (C) and without thyroid remnants (D) and euthyroid patients on T4 substitution (E). The arithmetic mean iodine excretion of the healthy volunteers in group A and individual B was found to be 87 +/- 40 micrograms I/g creatinine. This is insufficient according to the recommendations of the WHO. In all groups, the iodine excretion reached the recommended level only in some members: 24% (A, B), 19% (C), 38% (D) and 81% (E). It was thought in the 1980s that in a formerly iodine-deficient society, iodinated salt would continue to provide an adequate supply of iodine. However, iodine intake in this affluent society has proved to be unstable. This can be attributed to modifications of eating habits, which include a reduction of total salt consumption, combined with a growing consumption of manufactured food of cosmopolitan origin, prepared using salt containing little or no iodine.
authors.affiliation: Department of Nuclear Medicine, Inselspital, University of Berne, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Als
authors.forename: K
authors.initials: K
authors.lastname: Lauber
authors.forename: L
authors.initials: L
authors.lastname: Brander
authors.forename: D
authors.initials: D
authors.lastname: Lüscher
authors.forename: H
authors.initials: H
authors.lastname: Rösler
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004032:Diet; D005247:Feeding Behavior; D005260:Female; D006801:Humans; D007455:Iodine / Q000008:administration & dosage* / Q000172:deficiency / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013557:Switzerland; D013964:Thyroid Neoplasms / Q000209:etiology / Q000378:metabolism
chemical_list: D007455:Iodine