title: Tidal flow volume loops and inflammatory indicators in small children.
abstract: Serum eosinophilic cationic protein (sECP) serum myeloperoxidase (sMPO) and tidal flow volume loops were measured in 41 awake children with at least two episodes of bronchopulmonary obstruction, at least 3 weeks after an acute episode, and in 38 control children, all below 2 years of age. Reversibility to salbutamol was assessed in 26 cases and 24 controls. The baseline ratio of time to peak flow to total expiratory time (Tpef/Te) was significantly lower in cases (0.21) than in controls (0.33). sECP was significantly higher in cases (21.9 micrograms/l) than in controls (14.0 micrograms/l), and correlated significantly (r = 0.70) with the percentage change in Tpef/Te from before to after salbutamol. sMPO did not differ significantly between the two groups.
authors.affiliation: Voksentoppen Centre for Asthma and Allergy, Oslo, Norway.
authors.forename: K H
authors.initials: KH
authors.lastname: Carlsen
authors.forename: K C
authors.initials: KC
authors.lastname: Carlson
authors.forename: R
authors.initials: R
authors.lastname: Halvorsen
mesh_terms: D000402:Airway Obstruction / Q000150:complications / Q000175:diagnosis*; D000420:Albuterol; D001249:Asthma / Q000150:complications / Q000175:diagnosis*; D015415:Biomarkers; D001798:Blood Proteins / Q000032:analysis*; D016022:Case-Control Studies; D002675:Child, Preschool; D003937:Diagnosis, Differential; D047091:Eosinophil Granule Proteins; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D009195:Peroxidase / Q000097:blood*; D012008:Recurrence; D012135:Respiratory Sounds / Q000209:etiology*; D012260:Ribonucleases; D013990:Tidal Volume / Q000187:drug effects*
chemical_list: D015415:Biomarkers; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D009195:Peroxidase; D012260:Ribonucleases; D000420:Albuterol