[3H]MK-801 binding asymmetry in the IMHV region of dark-reared chicks is reversed by imprinting.
Glutamate NMDA-type receptor binding in the intermediate medial hyperstriatum ventrale (IMHV) of dark-hatched chicks is lateralized. This lateralization was found to be markedly influenced by imprinting. In dark-reared chicks the binding of the selective ligand [3H]MK-801 was two-fold higher in the right IMHV than in the left IMHV. In contrast, imprinted chicks have significantly higher levels of [3H]MK-801 binding in the left IMHV region than in the right IMHV. Imprinting results in 2a learning-related increase in NMDA-type receptor binding levels in the left IMHV, whereas [3H]MK-801 binding levels in the right IMHV remain unchanged by imprinting. Thus, the plasticity present in the NMDA-type receptor system and associated with imprinting appears to occur in the left hemisphere only.
Johnston
A N
AN
Department of Physiology, University of New England, Armidale, NSW, Australia.
Rogers
L J
LJ
Dodd
P R
PR
D000818:Animals; D002645:Chickens; D003624:Darkness; D016291:Dizocilpine Maleate / Q000378:metabolism*; D007839:Functional Laterality; D007173:Imprinting, Psychological; D016548:Prosencephalon / Q000378:metabolism*; D011869:Radioligand Assay; D016194:Receptors, N-Methyl-D-Aspartate / Q000378:metabolism*; D014316:Tritium
D016194:Receptors, N-Methyl-D-Aspartate; D014316:Tritium; D016291:Dizocilpine Maleate