Clinical significance of tissue polypeptide antigen in serum of acute nonlymphocytic leukemia.
Tissue polypeptide antigen (TPA) in serum was measured at diagnosis in 27 patients with acute nonlymphocytic leukemia (ANLL) (1 FAB M0, 1 M1, 10 M2, 7 M3, 5 M4, 1 M5, 1 M6 and 1 MU). Statistical analysis disclosed a close correlation of TPA level with age (P < 0.01), hemoglobin level (P < 0.05), therapeutic response (P < 0.01) and the length of survival after the initial diagnosis (P < 0.02). A significant difference in TPA level was present between patients with complete remission and those with poor response. To our knowledge, this is the first report to prove a correlation of TPA level with therapeutic response and the length of survival in ANLL.
Sadamori
N
N
Department of Hematology, Nagasaki University School of Medicine, Japan.
Mine
M
M
Kawachi
T
T
Hayashibara
T
T
Itoyama
T
T
Sasagawa
I
I
Nakamura
H
H
Tomonaga
M
M
D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D001854:Bone Marrow Cells; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D012016:Reference Values; D019396:Tissue Polypeptide Antigen; D016896:Treatment Outcome
D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006454:Hemoglobins; D010455:Peptides; D019396:Tissue Polypeptide Antigen