Premedication with Midazolam (Dormicum) compared with Promethazine, Droperidol and placebo in relieving anxiety using Beck's anxiety inventory.
In a randomized double-blind study, Midazolam (Dormicum) (7.5 mg) was compared with Promethazine (Phenergan) (25 mg), Droperidol (2.5 mg) and placebo as premedication for 98 pre-selected patients undergoing surgery. The anxiolytic effect of the above drugs was monitored by Beck's Anxiety Inventory. 83.3% of patients who received Midazolam had a decrease in their anxiety state compared to 55.6% for Promethazine, 12% for Droperidol and 25% for placebo. The study clearly proved that Midazolam is a better anxiolytic drug compared to Droperidol and Promethazine.
Jalbout
N
N
Department of Anaesthesia, Saint George Hospital, Beirut, Lebanon.
Karam
A N
AN
Karam
E
E
Feghaly
C
C
Khalaf
H
H
D000293:Adolescent; D000328:Adult; D000368:Aged; D001007:Anxiety / Q000517:prevention & control*; D001794:Blood Pressure / Q000187:drug effects; D004311:Double-Blind Method; D004329:Droperidol / Q000627:therapeutic use*; D016903:Drug Monitoring; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D008874:Midazolam / Q000627:therapeutic use*; D008875:Middle Aged; D010555:Personality Inventory; D010919:Placebos; D011292:Premedication; D011398:Promethazine / Q000627:therapeutic use*; D012119:Respiration / Q000187:drug effects
D010919:Placebos; D011398:Promethazine; D004329:Droperidol; D008874:Midazolam