Osteosarcoma, seasonality, and environmental factors in Wisconsin, 1979-1989.
Proxy exposure measures and readily available data from the Wisconsin Cancer Reporting System were used to contrast 167 osteosarcoma cases with 989 frequency-matched cancer referents reported during 1979-1989. Differences in potential exposure to water-borne radiation and fluoridated drinking water, population size for the listed place of residence, and seasonality were assessed. An association was found between osteosarcoma and residence in a population of less than 9,000 (odds ratio = 1.6, 95% confidence interval = 1.1-2.4). In addition, an association between month of birth (May through July versus other months of birth) and osteosarcoma among individuals who were less than 25 y of age (odds ratio = 1.9, 95% confidence interval = 1.1-3.4). Overall, no association was found between potential exposure to fluoridated drinking water and osteosarcoma (odds ratio = 1.0, 95% confidence interval = 0.6-1.5). The association between osteosarcoma and water-borne radiation was weak and was not significant statistically (odds ratio = 1.5, 95% confidence interval = 0.8-2.8).
Moss
M E
ME
Eastman Dental Center, Rochester, New York, USA.
Kanarek
M S
MS
Anderson
H A
HA
Hanrahan
L P
LP
Remington
P L
PL
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D001859:Bone Neoplasms / Q000453:epidemiology*; D002648:Child; D002675:Child, Preschool; D016001:Confidence Intervals; D005260:Female; D005457:Fluoridation; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000453:epidemiology; D016017:Odds Ratio; D012516:Osteosarcoma / Q000453:epidemiology*; D012111:Residence Characteristics; D012307:Risk Factors; D012621:Seasons; D012737:Sex Factors; D014878:Water Pollution, Radioactive; D014881:Water Supply; D014922:Wisconsin / Q000453:epidemiology