Sodium deoxycholate facilitates systemic absorption of verotoxin 2e from pig intestine.
Injection of verotoxin 2e together with sodium deoxycholate, which increases intestinal permeability to macromolecules, into the intestine of pigs resulted in fluid accumulation, intestinal damage, and signs and lesions of edema disease. Intragastric administration of verotoxin 2e to newborn piglets, who normally absorb protein nonspecifically, resulted in systemic verotoxemia. These results suggest that development of natural edema disease requires a state of increased intestinal permeability.
Waddell
T E
TE
Department of Veterinary Microbiology and Immunology, Ontario Veterinary College, University of Guelph, Canada.
Gyles
C L
CL
D000818:Animals; D000831:Animals, Newborn; D001427:Bacterial Toxins / Q000493:pharmacokinetics*; D003840:Deoxycholic Acid / Q000494:pharmacology*; D004487:Edema / Q000382:microbiology / Q000662:veterinary; D004768:Enterotoxins / Q000493:pharmacokinetics*; D005260:Female; D007408:Intestinal Absorption / Q000187:drug effects*; D022641:Shiga Toxin 2; D013552:Swine; D013553:Swine Diseases / Q000382:microbiology
D001427:Bacterial Toxins; D004768:Enterotoxins; D022641:Shiga Toxin 2; D003840:Deoxycholic Acid