title: Treatment of adenoma sebaceum with the copper vapor laser.
abstract: BACKGROUND
  Angiofibromas of the central part of the face (adenoma sebaceum) occur pathognomonically in tuberous sclerosis, causing significant cosmetic and hygienic morbidity. Treatment has included excision, dermabrasion, cryosurgery, carbon dioxide laser, and argon laser. Copper vapor lasers emit light at 511 nm (green) ad 578 nm (yellow), useful for treating pigmented and vascular lesions, respectively.
  
  
  OBJECTIVE
  Because of the vascular nature and progressive pigmentation of adenoma sebaceum, we examined the utility of the copper vapor laser in treating this disorder.
  
  
  METHODS
  Nine patients with adenoma sebaceum were treated with the copper vapor laser. Individual lesions were treated with the yellow light (578 nm) at 0.4 to 0.6 mW. Pigmented lesions or lesions resistant to treatment were treated with the green light (511 nm) at 0.4 to 0.9 mW. Intervals between treatments were at least 6 weeks.
  
  
  RESULTS
  Good to excellent cosmetic results were seen in all treated patients. Scarring or hyperpigmentation occurred in none of the patients. Most patients required additional treatments with the copper vapor laser as new lesions developed.
  
  
  CONCLUSIONS
  The copper vapor laser is safe and effective for the treatment of adenoma sebaceum in tuberous slerosis.
authors.affiliation: Department of Dermatology, University of California at San Francisco, School of Medicine, USA.
authors.forename: A J
authors.initials: AJ
authors.lastname: Kaufman
authors.forename: R C
authors.initials: RC
authors.lastname: Grekin
authors.forename: J K
authors.initials: JK
authors.lastname: Geisse
authors.forename: I J
authors.initials: IJ
authors.lastname: Frieden
mesh_terms: D000236:Adenoma / Q000150:complications / Q000532:radiotherapy*; D000293:Adolescent; D000328:Adult; D018322:Angiofibroma / Q000150:complications / Q000532:radiotherapy*; D002648:Child; D005153:Facial Neoplasms / Q000532:radiotherapy*; D005260:Female; D006801:Humans; D053685:Laser Therapy; D008297:Male; D012878:Skin Neoplasms / Q000150:complications / Q000532:radiotherapy*; D014402:Tuberous Sclerosis / Q000150:complications