title: Neospora caninum infection in three dogs.
abstract: Infection with Neospora caninum in three young dogs is described. The predominant clinical signs were lower motor neuron deficits of the pelvic limbs, bladder and rectum. In two cases there was liver infection and dysfunction. The younger dogs had an acute onset rapidly progressive syndrome. The older dog had a similar but more chronic course. The diagnosis was confirmed by an immunofluorescence antibody test. The parasite is sensitive to clindamycin and trimethoprim/sulphonamide preparations, however the prognosis for return to function is poor especially if muscle contracture has occurred.
authors.affiliation: Department of Small Animal Medicine and Surgery, Royal Veterinary College, North Mymms, Hertfordshire.
authors.forename: C
authors.initials: C
authors.lastname: Knowler
authors.forename: S J
authors.initials: SJ
authors.lastname: Wheeler
mesh_terms: D000208:Acute Disease; D000818:Animals; D000913:Antibodies, Protozoan / Q000032:analysis; D002525:Cerebellar Cortex / Q000469:parasitology / Q000473:pathology; D002908:Chronic Disease; D003048:Coccidiosis / Q000175:diagnosis / Q000469:parasitology / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000469:parasitology; D004285:Dogs; D005260:Female; D005455:Fluorescent Antibody Technique / Q000662:veterinary; D008109:Liver Diseases, Parasitic / Q000175:diagnosis / Q000469:parasitology / Q000662:veterinary; D016472:Motor Neuron Disease / Q000175:diagnosis / Q000469:parasitology / Q000662:veterinary; D009132:Muscles / Q000469:parasitology / Q000473:pathology; D018688:Neospora / Q000276:immunology / Q000302:isolation & purification*; D011379:Prognosis
chemical_list: D000913:Antibodies, Protozoan