title: Pharmacokinetics of triamcinolone acetonide after intravenous, oral, and inhaled administration.
abstract: The pharmacokinetics of triamcinolone acetonide were studied after intravenous (2 mg), oral (5 mg), and inhaled (2 mg) administration. Triamcinolone acetonide concentrations were measured in plasma by high-performance liquid chromatography/radioimmunoassay. After intravenous administration, triamcinolone acetonide was eliminated with a total body clearance of 37 L/h and a half-life of 2.0 hours. The volume of distribution was 103 L, and oral bioavailability averaged 23%. Absorption was rapid, achieving maximum triamcinolone acetonide levels of 10.5 ng/mL after 1 hour. After inhalation, bioavailability averaged 22% with maximum levels of 2.0 ng/mL observed after 2.1 hours. The resulting systemic levels for all three treatments caused a significant decrease in the number of lymphocytes in blood.
authors.affiliation: Department of Pharmaceutics, University of Florida, Gainesville, USA.
authors.forename: H
authors.initials: H
authors.lastname: Derendorf
authors.forename: G
authors.initials: G
authors.lastname: Hochhaus
authors.forename: S
authors.initials: S
authors.lastname: Rohatagi
authors.forename: H
authors.initials: H
authors.lastname: Möllmann
authors.forename: J
authors.initials: J
authors.lastname: Barth
authors.forename: H
authors.initials: H
authors.lastname: Sourgens
authors.forename: M
authors.initials: M
authors.lastname: Erdmann
mesh_terms: D000280:Administration, Inhalation; D000284:Administration, Oral; D001682:Biological Availability; D018592:Cross-Over Studies; D006207:Half-Life; D006801:Humans; D007275:Injections, Intravenous; D018655:Lymphocyte Count / Q000187:drug effects; D008214:Lymphocytes / Q000187:drug effects; D008297:Male; D008657:Metabolic Clearance Rate; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000493:pharmacokinetics* / Q000494:pharmacology
chemical_list: D014222:Triamcinolone Acetonide