Roquinimex-induced graft-versus-host reaction after autologous bone marrow transplantation.
BACKGROUND
Roquinimex is being used for posttransplantation immunotherapy of autologous bone marrow transplantation for acute and chronic myelogenous leukemia. This immunotherapeutic agent is a cytokine inducer and may induce an autologous graft-versus-host (GVH) and graft-versus-tumor reactions.


OBJECTIVE
Our purpose was to examine patients undergoing this immunotherapy for clinical signs and symptoms of acute GVH reactions and to correlate these symptoms with their clinical outcome.


METHODS
We studied eight patients receiving requinimex therapy.


RESULTS
We found autologous GVH reactions in three of eight patients (38%) treated with this immunotherapy. Their disease was manifested by localized or widespread violaceous papules that on histologic evaluation were compatible with a grade II GVH reaction. The acute cutaneous GVH reaction was associated with eccrine sweat gland necrosis, a dermatologic toxicity usually associated with chemotherapy.


CONCLUSIONS
Long-term studies of larger numbers of patients treated with this immunotherapy will determine whether these GVH reactions confer significant, sustained, antitumor effects.
Gaspari
A A
AA
Department of Dermatology, University of Rochester School of Medicine and Dentistry, NY, USA.
Cheng
S F
SF
DiPersio
J F
JF
Rowe
J M
JM
D000208:Acute Disease; D000276:Adjuvants, Immunologic / Q000009:adverse effects*; D016026:Bone Marrow Transplantation; D005260:Female; D006087:Graft vs Host Reaction / Q000187:drug effects*; D006801:Humans; D006912:Hydroxyquinolines / Q000009:adverse effects*; D007951:Leukemia, Myeloid / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009336:Necrosis; D012867:Skin / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology / Q000473:pathology; D013545:Sweat Glands / Q000473:pathology; D014182:Transplantation, Autologous
D000276:Adjuvants, Immunologic; D006912:Hydroxyquinolines; C045282:roquinimex