title: Depression-induced absenteeism in relation to antihyperlipidemic treatment: a study using GAZEL cohort data.
abstract: We examined the relation between overall 1-year exposure to diet and drugs prescribed for hyperlipidemia and the occurrence of medically certified absence from work with depression during the year of exposure (N = 289). The 17,244 persons studied are middle-aged employees of a national company who volunteered as cohort participants. Depression was more prevalent among those exposed to an antihyperlipidemic diet (N = 1,614) than among those unexposed. After stratification by sex and professional status, we found a prevalence ratio (PR) of 1.83 [95% confidence interval (CI) = 1.30-2.58]. Exposure to simvastatin (N = 376) produced comparable results, with a prevalence ratio of 2.18 (95% CI = 1.18-4.03). For subjects who were not cases in the year of exposure assessment, the hypolipidemic treatments are not associated with depression-induced absenteeism the following year. Our results point to a possible role of prescribed diet and simvastatin in depression-related absenteeism.
authors.affiliation: Institut National de la Santé et de la Recherche Médicale (INSERM) U88, Saint Maurice, France.
authors.forename: E
authors.initials: E
authors.lastname: Boumendil
authors.forename: P
authors.initials: P
authors.lastname: Tubert-Bitter
mesh_terms: D000041:Absenteeism; D000328:Adult; D015331:Cohort Studies; D003863:Depression / Q000139:chemically induced / Q000209:etiology*; D018752:Diet, Fat-Restricted / Q000009:adverse effects; D005260:Female; D005602:France; D006801:Humans; D006949:Hyperlipidemias / Q000178:diet therapy / Q000188:drug therapy*; D000960:Hypolipidemic Agents / Q000009:adverse effects* / Q000627:therapeutic use; D008148:Lovastatin / Q000009:adverse effects / Q000031:analogs & derivatives / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009790:Occupations; D017891:Pharmacoepidemiology; D015995:Prevalence; D012307:Risk Factors; D019821:Simvastatin; D011795:Surveys and Questionnaires
chemical_list: D000960:Hypolipidemic Agents; D008148:Lovastatin; D019821:Simvastatin