[Effect of pefloxacin on luminol-dependent chemiluminescence and leukocyte adhesion].
The in vitro action of pefloxacin on the luminole-dependent chemiluminescence and adherence of polymorphonuclear leukocytes of guinea pigs was studied within a wide range of the concentrations from 0.1 to 100 micrograms/ml. Pefloxacin did not influence the peak values of the chemiluminescence while in concentrations of 0.1 to 10 micrograms/ml it retarded its attenuation. After incubation of the leukocytes in the presence of 100 micrograms/ml of pefloxacin and the subsequent washing out the drug there was observed a decrease in the chemiluminescence. In concentrations of 0.1 to 100 micrograms/ml pefloxacin had no significant effect on the leukocyte adherence.
Smolkina
T V
TV
Iordanova
A I
AI
Iudin
S M
SM
Nikitin
A V
AV
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D006168:Guinea Pigs; D006801:Humans; D008163:Luminescent Measurements; D008165:Luminol; D009503:Neutropenia / Q000188:drug therapy; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects*; D015366:Pefloxacin / Q000009:adverse effects / Q000494:pharmacology*
D015366:Pefloxacin; D008165:Luminol