title: Restriction endonucleases functionally interacting with two DNA sites.
abstract: Simultaneous interaction with two recognition sites was found to be a precondition for DNA cleavage by certain type-II and type-III restriction endonucleases. Nevertheless, the molecular mechanisms of the protein-DNA interaction are different between members of both classes of enzymes.
authors.affiliation: Institute of Medical Virology, Humboldt University School of Medicine (Charité), Berlin, Germany.
authors.forename: D H
authors.initials: DH
authors.lastname: Krüger
authors.forename: D
authors.initials: D
authors.lastname: Kupper
authors.forename: A
authors.initials: A
authors.lastname: Meisel
authors.forename: M
authors.initials: M
authors.lastname: Tierlich
authors.forename: M
authors.initials: M
authors.lastname: Reuter
authors.forename: C
authors.initials: C
authors.lastname: Schroeder
mesh_terms: D001665:Binding Sites; D004247:DNA / Q000737:chemistry* / Q000378:metabolism*; D015252:Deoxyribonucleases, Type II Site-Specific / Q000378:metabolism*; D015263:Deoxyribonucleases, Type III Site-Specific / Q000378:metabolism*
chemical_list: D004247:DNA; D015252:Deoxyribonucleases, Type II Site-Specific; D015263:Deoxyribonucleases, Type III Site-Specific