The Paul Kallós Memorial Lecture. From slow-reacting substance of anaphylaxis to leukotriene C4 synthase.
The hypothesis of 35 years ago that slowreacting substance of anaphylaxis would prove to be a pathobiologic mediator of reversible airway disease in the human has been validated. The multidisciplinary approach required to achieve this goal has been particularly prominent and consistent for the entire period in the program described in this presentation.
Austen
K F
KF
Department of Medicine, Harvard Medical School, Boston, Mass., USA.
D000402:Airway Obstruction / Q000209:etiology; D000707:Anaphylaxis / Q000150:complications / Q000276:immunology* / Q000503:physiopathology; D000818:Animals; D003001:Cloning, Molecular; D005395:Fish Oils / Q000494:pharmacology / Q000627:therapeutic use; D005796:Genes; D005982:Glutathione Transferase / Q000235:genetics / Q000266:history* / Q000502:physiology; D006168:Guinea Pigs; D000882:Haplorhini; D049673:History, 20th Century; D006801:Humans; D017997:Leukotriene C4 / Q000096:biosynthesis / Q000502:physiology; D008131:London; D008168:Lung / Q000503:physiopathology; D008404:Massachusetts; D051381:Rats; D013189:SRS-A / Q000266:history* / Q000502:physiology
D005395:Fish Oils; D013189:SRS-A; D017997:Leukotriene C4; D005982:Glutathione Transferase; C041116:leukotriene-C4 synthase