[Lymphogenic introduction into lesser circulation of orally administered rifampicin in standard and liposomal forms].
Pharmacokinetics of water and liposomal suspensions of lipophilic antibiotic rifampicin introduced intragastrically through a tube was studied in experiments on Wistar rats. After administration of water suspension rifampicin concentration reached its peak in all the tissues in 3 hours, lung concentration being 1.6 and 1.9 times higher than blood one. After liposomal suspension administration lymphatic rifampicin concentrations were maximal in 3 hours, while in the lungs and blood they were the highest in 6 hours. It is concluded that oral liposoluble drug enter primarily chyle vessels and via thoracic lymphatic duct directly lesser circulation. Liposomal inclusion of the drug warrants its high concentration in lymphatic system and lung tissue.
Petrenko
T I
TI
Ursov
I G
IG
Kurunov
Iu N
IuN
Borodin
Iu I
IuI
Sidorova
L D
LD
D000284:Administration, Oral; D000818:Animals; D004337:Drug Carriers; D008081:Liposomes; D008168:Lung / Q000378:metabolism; D008196:Lymph / Q000378:metabolism; D008297:Male; D011652:Pulmonary Circulation; D051381:Rats; D017208:Rats, Wistar; D012293:Rifampin / Q000008:administration & dosage* / Q000378:metabolism / Q000493:pharmacokinetics*
D004337:Drug Carriers; D008081:Liposomes; D012293:Rifampin