c-fos and jun-B mRNAs are transiently expressed in fetal rodent suprachiasmatic nucleus following dopaminergic stimulation.
We examined the time-course of expression of c-fos and jun-B mRNAs in the fetal rat suprachiasmatic nuclei (SCN) following maternal cocaine injection on gestational day 20. Both c-fos and jun-B mRNA levels increased within 20 min, peaked at 40 min and declined to baseline by 120 min after cocaine treatment (30 mg/kg). In mice, the D1-dopamine agonist, SKF 38393, induced c-fos and jun-B mRNAs in the fetal SCN and striatum. Regulated expression of immediate early genes in the fetal SCN may play a role in entrainment of the fetal clock.
Weaver
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Laboratory of Developmental Chronobiology, Massachusetts General Hospital, Boston 02114, USA.
Roca
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Reppert
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D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine / Q000494:pharmacology*; D000818:Animals; D002940:Circadian Rhythm; D003042:Cocaine / Q000494:pharmacology*; D004298:Dopamine / Q000378:metabolism; D005260:Female; D005333:Fetus; D015870:Gene Expression; D017781:Genes, Immediate-Early / Q000187:drug effects / Q000502:physiology; D005865:Gestational Age; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D016760:Proto-Oncogene Proteins c-fos / Q000378:metabolism*; D016755:Proto-Oncogene Proteins c-jun / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism; D051381:Rats; D013493:Suprachiasmatic Nucleus / Q000187:drug effects / Q000378:metabolism*; D013997:Time Factors
D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D012333:RNA, Messenger; D015647:2,3,4,5-Tetrahydro-7,8-dihydroxy-1-phenyl-1H-3-benzazepine; D003042:Cocaine; D004298:Dopamine