title: A pilot study to evaluate the development of resistance to nevirapine in asymptomatic human immunodeficiency virus-infected patients with CD4 cell counts of > 500/mm3: AIDS Clinical Trials Group Protocol 208.
abstract: Treatment of human immunodeficiency virus (HIV) infection with nevirapine in patients with < 400 CD4 cells/mm3 rapidly selects for virus with reduced susceptibility to nevirapine. To test whether resistance would develop less quickly in patients with a lower virus burden, nevirapine was studied in asymptomatic patients with > 500 CD4 cells/mm3. With 400 mg of nevirapine daily, the median reduction in HIV RNA was 0.51 log10 copies/mL, and all isolates recovered by 12 weeks were resistant to nevirapine. As in patients with lower CD4 cell counts, some patients experienced sustained reduction in plasma HIV RNA despite the presence of resistant virus. These results suggest that lower levels of HIV RNA and immunosuppression did not retard the rate of emergence of nevirapine-resistant virus; also, a polymerase chain reaction-based HIV RNA assay is sufficiently sensitive to evaluate the antiviral effect of a drug in patients with > 500 CD4 cells/mm3.
authors.affiliation: Department of Medicine, University of California, San Diego, La Jolla, USA.
authors.forename: D
authors.initials: D
authors.lastname: Havlir
authors.forename: M M
authors.initials: MM
authors.lastname: McLaughlin
authors.forename: D D
authors.initials: DD
authors.lastname: Richman
mesh_terms: D000998:Antiviral Agents / Q000627:therapeutic use*; D018791:CD4 Lymphocyte Count; D002986:Clinical Trials as Topic; D004352:Drug Resistance, Microbial; D005260:Female; D006678:HIV / Q000302:isolation & purification; D006679:HIV Seropositivity / Q000188:drug therapy* / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy; D008297:Male; D019829:Nevirapine; D010865:Pilot Projects; D016133:Polymerase Chain Reaction / Q000379:methods; D011725:Pyridines / Q000627:therapeutic use*; D012367:RNA, Viral / Q000032:analysis; D012044:Regression Analysis; D013997:Time Factors
chemical_list: D000998:Antiviral Agents; D011725:Pyridines; D012367:RNA, Viral; D019829:Nevirapine