The use of recombinant factor VIIa in a patient with acquired haemophilia A undergoing surgery.
An elderly woman with acquired haemophilia A secondary to a monoclonal gammopathy, required elective surgery for a parotid tumour but was unable to tolerate conventional treatment. Recombinant activated factor VII (rVIIa) was used successfully to cover a biopsy and then subsequent resection of the tumour. The use of rVIIa in the management of acquired inhibitors is discussed.
Doughty
H A
HA
Haemophilia Centre, St Thomas' Hospital, London, UK.
Northeast
A
A
Sklair
L
L
Roques
T
T
Young
A E
AE
Savidge
G F
GF
Hunt
B J
BJ
D000368:Aged; D017558:Elective Surgical Procedures; D015942:Factor VIIa / Q000627:therapeutic use*; D005260:Female; D006467:Hemophilia A / Q000188:drug therapy* / Q000209:etiology; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D011994:Recombinant Proteins / Q000627:therapeutic use
D011994:Recombinant Proteins; D015942:Factor VIIa