Loratadine produces antihistamine activity without adverse CNS, ECG or cardiovascular effects in guinea pigs. Comparative studies with terfenadine and sedating antihistamines.
Hey
J A
JA
Schering-Plough Research Institute, Kenilworth, NJ 07033-0539, USA.
del Prado
M
M
Egan
R W
RW
Sherwood
J
J
Kreutner
W
W
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000139:chemically induced; D004155:Diphenhydramine / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity; D004353:Drug Evaluation, Preclinical; D004562:Electrocardiography / Q000187:drug effects; D004569:Electroencephalography / Q000187:drug effects*; D006168:Guinea Pigs; D006439:Hemodynamics / Q000187:drug effects*; D017336:Loratadine / Q000493:pharmacokinetics / Q000494:pharmacology* / Q000633:toxicity; D011398:Promethazine / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity; D011969:Receptors, Histamine H1 / Q000187:drug effects*; D012890:Sleep / Q000187:drug effects; D016593:Terfenadine / Q000493:pharmacokinetics / Q000494:pharmacology / Q000633:toxicity; D016171:Torsades de Pointes / Q000139:chemically induced
D011969:Receptors, Histamine H1; D017336:Loratadine; D016593:Terfenadine; D004155:Diphenhydramine; D011398:Promethazine