title: Inhibition of lens aldose reductase by biflavones from Ouratea spectabilis.
abstract: Two biflavonoids were isolated from the EtOH extract from leaves of Ouratea spectabilis. Their structures were established to be the novel 6,6"-bigenkwanin and 7,7"-dimethoxyagathisflavone on the basis of spectroscopic data. The inhibition of bovine lens aldose reductase exerted by these biflavones has been studied.
authors.affiliation: Seção de Farmacologia, Instituto Biológico, São Paulo, Brasil.
authors.forename: J D
authors.initials: JD
authors.lastname: Felício
authors.forename: E
authors.initials: E
authors.lastname: Gonçalez
authors.forename: M M
authors.initials: MM
authors.lastname: Braggio
authors.forename: L
authors.initials: L
authors.lastname: Costantino
authors.forename: A
authors.initials: A
authors.lastname: Albasini
authors.forename: A P
authors.initials: AP
authors.lastname: Lins
mesh_terms: D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D002417:Cattle; D005419:Flavonoids / Q000302:isolation & purification / Q000494:pharmacology*; D007700:Kinetics; D007908:Lens, Crystalline / Q000201:enzymology*; D015394:Molecular Structure; D018515:Plant Leaves; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship
chemical_list: D005419:Flavonoids; D000449:Aldehyde Reductase