Delayed febrile response in old rats is not associated with an inability of hypothalamus to produce prostaglandin E2.
E. coli lipopolysaccharide (100 micrograms per rat, i.p.) induced a twofold increase in hypothalamic prostaglandin E2 (PGE2) production both in young adult (8 months) and old (28-30 months) male Wistar rats. It seems that the ability of the hypothalamus to produce PGE2 in response to bacterial endotoxin is not affected with aging, and hence delayed febrile response observed in old rats is not related to hypothalamic PGE2 production.
Fraifeld
V
V
Department of Clinical Pharmacology, Corob Center for Medical Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Abramovich
L
L
Kaplanski
J
J
D000375:Aging / Q000378:metabolism*; D000818:Animals; D015232:Dinoprostone / Q000096:biosynthesis*; D004731:Endotoxins; D005334:Fever / Q000378:metabolism*; D007031:Hypothalamus / Q000378:metabolism*; D008070:Lipopolysaccharides; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time
D004731:Endotoxins; D008070:Lipopolysaccharides; C044101:endotoxin, Escherichia coli; D015232:Dinoprostone