Male reproductive potential after MOPP therapy for Hodgkin's disease: a long-term survey.
The testicular function of 47 men who had been treated by MOPP chemotherapy for a Hodgkin's disease was studied in a long-term survey. Azoospermia was constant during at least 14 months after completion of the treatment. After a follow-up period of 89.4 +/- 54.7 months, 26 men were still azoospermic. No correlation could be found between the therapeutic regimen and the results of semen analysis. For the same treatment, some men recovered spermatogenesis within 5 years, others after more than 10 years while some were still azoospermic after 20 years. However, the association of infra-diaphragmatic irradiation to high dose MOPP therapy had a profound detrimental effect on spermatogenesis: only 3/13 men recovered. Sperm recovery was often incomplete: 17/21 men had a sperm count below 20 million ml-1. Yet, spontaneous pregnancies were obtained with severe oligozoospermia: only 1/11 sperm counts performed close to fertilization exceeded 20 million ml-1, and 8 were below 5 millions ml-1. FSH failed to be either a sensitive or a specific marker of sperm recovery, a discrepancy between FSH level and spermiogram being noticed in 18.2% of cases.
Marmor
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Unité de Médecine de la Reproduction, Hôpital Saint-Antoine, Paris, France.
Duyck
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F
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000494:pharmacology / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D005260:Female; D005298:Fertility / Q000187:drug effects* / Q000528:radiation effects; D005640:Follicle Stimulating Hormone / Q000097:blood; D005500:Follow-Up Studies; D006689:Hodgkin Disease / Q000188:drug therapy* / Q000532:radiotherapy; D006801:Humans; D007986:Luteinizing Hormone / Q000097:blood; D008297:Male; D008466:Mechlorethamine / Q000008:administration & dosage; D011241:Prednisone / Q000008:administration & dosage; D011247:Pregnancy; D011344:Procarbazine / Q000008:administration & dosage; D011388:Prolactin / Q000097:blood; D012661:Semen / Q000502:physiology; D013091:Spermatogenesis / Q000187:drug effects* / Q000528:radiation effects; D013737:Testis / Q000187:drug effects / Q000528:radiation effects; D013739:Testosterone / Q000097:blood; D014750:Vincristine / Q000008:administration & dosage
D011344:Procarbazine; D013739:Testosterone; D008466:Mechlorethamine; D014750:Vincristine; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D011241:Prednisone