title: MtDNA polymorphisms in a sample of Czechoslovaks and in two groups of Italians.
abstract: Mitochondrial DNA (mtDNA) variation was investigated in a group of 185 unrelated individuals (64 Czechoslovaks, 99 Northern and 28 Central Italians) using total blood DNA and the six restriction enzymes HpaI, BamHI, HaeII, MspI, AvaII and HincII. Among the 25 patterns (morphs) found, two morphs for HaeII, one for MspI and one for AvaII were new and each was represented by a single individual from Northern Italy. They account for four of the five new types encountered in this survey, being the fifth type characterized by the presence of the very rare morph HaeII-13. The populations analysed confirm the Caucasoid characteristics of certain polymorphisms. A review of the European data available so far is reported.
authors.affiliation: Dipartimento di Biologia e Genetica per le Scienze Mediche, Università di Milano, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Brega
authors.forename: G
authors.initials: G
authors.lastname: Mura
authors.forename: S
authors.initials: S
authors.lastname: Caccio
authors.forename: O
authors.initials: O
authors.lastname: Semino
authors.forename: R
authors.initials: R
authors.lastname: Brdicka
authors.forename: A S
authors.initials: AS
authors.lastname: Santachiara-Benerecetti
mesh_terms: D003604:Czechoslovakia; D004272:DNA, Mitochondrial / Q000097:blood / Q000235:genetics; D004586:Electrophoresis; D005787:Gene Frequency; D006801:Humans; D007558:Italy; D017354:Point Mutation; D011110:Polymorphism, Genetic; D012150:Polymorphism, Restriction Fragment Length; D015183:Restriction Mapping; D044465:White People / Q000235:genetics
chemical_list: D004272:DNA, Mitochondrial