title: Estimation of acute toxicity by fitting a dose-time-response surface.
abstract: In acute toxicity testing, organisms are continuously exposed to progressively increasing concentrations of a chemical and deaths of test organisms are recorded at several selected times. The results of the test are traditionally summarized by a dose-response curve, and the time course of effect is usually ignored for lack of a suitable model. A model which integrates the combined effects of dose and exposure duration on response is derived from the biological mechanisms of aquatic toxicity, and a statistically efficient approach for estimating acute toxicity by fitting the proposed model is developed in this paper. The proposed procedure has been computerized as software and a typical data set is used to illustrate the theory and procedure. The new statistical technique is also tested by a data base of a variety of chemical and fish species.
authors.affiliation: Department of Statistics, University of Missouri, Columbia 65211, USA.
authors.forename: K
authors.initials: K
authors.lastname: Sun
authors.forename: G F
authors.initials: GF
authors.lastname: Krause
authors.forename: F L
authors.initials: FL
authors.lastname: Mayer
authors.forename: M R
authors.initials: MR
authors.lastname: Ellersieck
authors.forename: A P
authors.initials: AP
authors.lastname: Basu
mesh_terms: D000465:Algorithms; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure / Q000009:adverse effects; D005399:Fishes; D016013:Likelihood Functions; D008956:Models, Chemical; D018038:Sodium Selenite / Q000633:toxicity; D012984:Software; D013997:Time Factors; D014116:Toxicology; D014873:Water Pollutants / Q000633:toxicity
chemical_list: D014873:Water Pollutants; D018038:Sodium Selenite