title: Apoptosis induced by high- and low-LET radiations.
abstract: Cell death after irradiation occurs by apoptosis in certain cell populations in tissues. The phenomenon also occurs after high linear energy transfer (LET) irradiation, and the relative biological effectiveness (RBE) is 3 to 4 (with respect to low-LET radiation and apoptosis in intestinal crypts) for neutrons with energies of 14 MeV and up to 600 MeV. It is thought that p53 plays a role in the phenomenon, as radiation-induced apoptosis is not observed in p53-null animals.
authors.affiliation: CRC Department of Experimental Radiation Oncology, Paterson Institute for Cancer Research, Christie Hospital (NHS) Trust, Manchester, UK.
authors.forename: J H
authors.initials: JH
authors.lastname: Hendry
authors.forename: C S
authors.initials: CS
authors.lastname: Potten
authors.forename: A
authors.initials: A
authors.lastname: Merritt
mesh_terms: D000818:Animals; D017209:Apoptosis / Q000528:radiation effects*; D004307:Dose-Response Relationship, Radiation; D016158:Genes, p53; D006801:Humans; D007420:Intestine, Large / Q000473:pathology / Q000528:radiation effects*; D007421:Intestine, Small / Q000473:pathology / Q000528:radiation effects*; D018499:Linear Energy Transfer; D051379:Mice; D008815:Mice, Inbred Strains; D008817:Mice, Mutant Strains