title: Dexamethasone and cyclosporin A suppress mast cell-leukocyte cytokine cascades by multiple mechanisms.
abstract: Based on in vitro findings with mouse mast cells and in vivo findings in mice, we report that dexamethasone or cyclosporin A can have at least three actions which interfere with the pathogenesis IgE-, mast-cell-, and cytokine-dependent inflammatory reactions: suppression of the IgE-dependent increase in tumor necrosis factor (TNF)-alpha mRNA by mast cells, inhibition of the IgE-dependent production of TNF-alpha protein by mast cells, and diminution of the responsiveness of target cells to TNF-alpha. Our findings in mice raise the possibility that similar actions of these agents in humans may account for some of the clinical efficacy of corticosteroids and cyclosporin A in allergic diseases.
authors.affiliation: Combined Program in Pediatric Gastroenterology, Children's Hospital, Boston, Mass., USA.
authors.forename: B K
authors.initials: BK
authors.lastname: Wershil
authors.forename: G T
authors.initials: GT
authors.lastname: Furuta
authors.forename: J A
authors.initials: JA
authors.lastname: Lavigne
authors.forename: A R
authors.initials: AR
authors.lastname: Choudhury
authors.forename: Z S
authors.initials: ZS
authors.lastname: Wang
authors.forename: S J
authors.initials: SJ
authors.lastname: Galli
mesh_terms: D000818:Animals; D016572:Cyclosporine / Q000494:pharmacology*; D003907:Dexamethasone / Q000494:pharmacology*; D004357:Drug Synergism; D007073:Immunoglobulin E / Q000276:immunology; D007962:Leukocytes / Q000187:drug effects* / Q000378:metabolism; D008407:Mast Cells / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis / Q000378:metabolism*
chemical_list: D014409:Tumor Necrosis Factor-alpha; D007073:Immunoglobulin E; D003907:Dexamethasone; D016572:Cyclosporine