Influence of vitamin E on preventive or therapeutic effect of MFA and DTPA in cadmium toxicity.
The influence of vitamin E supplementation on the ability of alpha-mercapto-beta(2-furyl) acrylic acid (MFA) or calcium trisodium diethylenetriamine pentaacetate (DTPA) to reduce body burden of cadmium and reverse Cd-induced biochemical alterations was investigated in Cd-exposed rats. The treatment with MFA-vitamin E or CaNa3 DTPA-vitamin E was more effective than either vitamin E or chelating agent alone, in depleting blood and tissue Cd. However, the combined treatment showed only limited advantage over the individuals in restoring Cd-induced biochemical changes. Further, the treatment with chelator-vitamin E concomitantly with the exposure to Cd was more effective than post-Cd exposure treatment.
Tandon
S K
SK
Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Singh
S
S
D000179:Acrylates / Q000627:therapeutic use*; D000818:Animals; D001822:Body Burden; D002104:Cadmium / Q000633:toxicity*; D015913:Chelation Therapy; D004357:Drug Synergism; D008297:Male; D004369:Pentetic Acid / Q000627:therapeutic use*; D051381:Rats; D014810:Vitamin E / Q000627:therapeutic use*
D000179:Acrylates; D002104:Cadmium; D014810:Vitamin E; C015341:2-mercapto-3-furan-2-ylpropenoic acid; D004369:Pentetic Acid