title: The emergence of free radicals after acoustic trauma and strial blood flow.
abstract: The effect of acoustic trauma on cochlear strial circulation was investigated immunohistologically in the guinea pig. Kanamycin was used as a tracer of blood flow. Moreover, histochemical examinations were made to reveal the emergence of free radicals in the cochlea following acoustic trauma. At 5 min (5 min after intense sound exposure 120-125 dB SPL, 3 h) the blood flow in the stria vascularis was greatly diminished. At 2 h the strial blood flow started to recirculate and at 6 h it appeared to have returned to normal. Superoxide anion radicals (O2-) emerged along the luminal membrane of the marginal cells of the stria vascularis at 5 min. O2- disappeared at 30 min, but reappeared at 2 h. The cause of its emergence at 5 min was obscure. However, the strange phenomenon that O2- emerged again at 2 h seemed ascribable to the re-circulation of strial blood flow after sound exposure.
authors.affiliation: Department of Otolaryngology, Osaka City University Medical School, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamane
authors.forename: Y
authors.initials: Y
authors.lastname: Nakai
authors.forename: M
authors.initials: M
authors.lastname: Takayama
authors.forename: K
authors.initials: K
authors.lastname: Konishi
authors.forename: H
authors.initials: H
authors.lastname: Iguchi
authors.forename: T
authors.initials: T
authors.lastname: Nakagawa
authors.forename: S
authors.initials: S
authors.lastname: Shibata
authors.forename: A
authors.initials: A
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Sunami
authors.forename: C
authors.initials: C
authors.lastname: Kawakatsu
mesh_terms: D000818:Animals; D003051:Cochlea / Q000098:blood supply*; D005609:Free Radicals / Q000378:metabolism; D006168:Guinea Pigs; D006317:Hearing Loss, Noise-Induced / Q000503:physiopathology*; D006651:Histocytochemistry; D007158:Immunologic Techniques; D007612:Kanamycin; D012039:Regional Blood Flow; D013481:Superoxides / Q000378:metabolism*
chemical_list: D005609:Free Radicals; D013481:Superoxides; D007612:Kanamycin