title: Prevalence of visual deficits in Alzheimer's disease.
abstract: This study addressed the issue of prevalence and pattern of visual deficits in 77 subjects with Alzheimer's disease (AD) and 111 healthy control subjects. We defined cutoff scores that would be expected from only 1 control subject of 100 (p = 0.01). The percentage of AD subjects who performed at or worse than this level varied across the 16 visual tests from a high of 58% to a low of 0%. The distribution of impairment across tests suggests a high vulnerability in AD of pattern vision, moderate vulnerability of spatial vision, and low vulnerability of motion and flicker perception. We found evidence for heterogeneity in the AD subject group: a subgroup (N = 14) emerged that was characterized by poor performance on the Backward Pattern Masking test, relatively young age, and relatively short duration of AD. Overall, the results indicate that visual dysfunction, especially on Backward Masking, is a common sign of AD.
authors.affiliation: Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Mendola
authors.forename: A
authors.initials: A
authors.lastname: Cronin-Golomb
authors.forename: S
authors.initials: S
authors.lastname: Corkin
authors.forename: J H
authors.initials: JH
authors.lastname: Growdon
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D008875:Middle Aged; D015995:Prevalence; D014786:Vision Disorders / Q000453:epidemiology / Q000209:etiology* / Q000503:physiopathology; D014787:Vision Tests; D014796:Visual Perception / Q000502:physiology