title: Echocardiographic assessment of aortic valve replacement with stentless porcine xenografts.
abstract: Stentless porcine xenografts (SPXs) implanted in the aortic position have potential hemodynamic advantages over traditional valve prostheses because of the lack of a rigid stent. Twenty-four patients (mean age 59 years) who underwent aortic valve replacement with SPXs were studied by echocardiography early after and 26 +/- 10 months (range 8 to 40) after operation. Peak and mean gradients, as well as aortic valve area, did not change significantly from baseline (16.3 +/- 8 and 9.8 +/- 5.6 mm Hg, and 1.78 +/- 0.63 cm2, respectively) to follow-up study (12.5 +/- 5 and 7.7 +/- 3 mm Hg, and 1.8 +/- 0.65 cm2, respectively). At baseline, color flow Doppler imaging showed aortic valve regurgitation where the leaflets coapted centrally in 17 of 24 patients (trivial, n = 14; mild, n = 3). Besides the central leak, paravalvular regurgitation was seen in 4 patients (trivial, n = 3; mild, n = 1). At follow-up, 18 of 24 patients had aortic valve regurgitation (trivial, n = 11; mild, n = 6; and moderate, n = 1). New valvular regurgitation (graded as trivial, n = 2; mild, n = 2; and moderate, n = 1) was detected in 5 patients, and new paravalvular regurgitation (graded as mild) developed in 1 patient. Two patients underwent repeat operation for valve-related complications: (1) rupture of a valve cusp with acute pulmonary edema, and (2) fibrotic stenosis of the left coronary ostium with unstable angina. In conclusion, this study demonstrates good hemodynamic performance of the SPX in the aortic position.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Istituto di Cardiologia, Universitá degli Studi di Cagliari, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Meloni
authors.forename: A
authors.initials: A
authors.lastname: Ricchi
authors.forename: E
authors.initials: E
authors.lastname: Cirio
authors.forename: S
authors.initials: S
authors.lastname: Falchi
authors.forename: P A
authors.initials: PA
authors.lastname: Abbruzzese
authors.forename: G M
authors.initials: GM
authors.lastname: Aru
authors.forename: V
authors.initials: V
authors.lastname: Martelli
authors.forename: D
authors.initials: D
authors.lastname: Ross
authors.forename: A
authors.initials: A
authors.lastname: Cherchi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001021:Aortic Valve / Q000000981:diagnostic imaging; D001022:Aortic Valve Insufficiency / Q000000981:diagnostic imaging / Q000209:etiology / Q000503:physiopathology; D001705:Bioprosthesis / Q000009:adverse effects / Q000295:instrumentation*; D018618:Echocardiography, Doppler, Color; D005260:Female; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis / Q000009:adverse effects / Q000295:instrumentation*; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012086:Reoperation / Q000706:statistics & numerical data; D015607:Stents