title: Experimental study of the embryogenesis of open spinal dysraphism.
abstract: This article discusses the experimental studies that have been performed to make clear the embryogenesis of myeloschisis or spina bifida. Some of these theories include: Simple nonclosure; overgrowth and nonclosure; so-called reopening; overgrowth and reopening; and primary mesodermal insufficiency. The authors also discuss recent investigations and give a view into the future.
authors.affiliation: Department of Neurosurgery, Kakogawa Municipal Hospital, Hyogo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Urui
authors.forename: S
authors.initials: S
authors.lastname: Oi
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008591:Meningomyelocele / Q000196:embryology* / Q000473:pathology; D011247:Pregnancy; D051381:Rats; D016137:Spina Bifida Cystica / Q000196:embryology* / Q000473:pathology; D013116:Spinal Cord / Q000196:embryology / Q000473:pathology