Intracatheter amphotericin B retention for fungal peritonitis in continuous ambulatory peritoneal dialysis.
Two patients who developed fungal peritonitis after receiving continuous ambulatory peritoneal dialysis (CAPD) for various periods were successfully treated with intracatheter retention of amphotericin B and oral flucytosine for 5 weeks. The catheter was not removed and efficient peritoneal permeability was maintained. We suggest that intracatheter retention of antifungal agents to sterilize the catheter along with simultaneous oral antifungal agents be used to eradicate peritoneal infection. The catheter may not need to be removed, and CAPD can be accomplished. The period of hospitalization may, thereby, be shortened, and the efficiency of CAPD can be maintained.
Lee
S H
SH
Department of Medicine, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan R.O.C.
Chiang
S S
SS
Hseih
S J
SJ
Shen
H M
HM
D000284:Administration, Oral; D000666:Amphotericin B / Q000008:administration & dosage* / Q000627:therapeutic use; D002408:Catheters, Indwelling; D004359:Drug Therapy, Combination; D005260:Female; D005437:Flucytosine / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy* / Q000209:etiology; D010531:Peritoneal Dialysis, Continuous Ambulatory / Q000009:adverse effects*; D010538:Peritonitis / Q000188:drug therapy* / Q000209:etiology
D000666:Amphotericin B; D005437:Flucytosine