Hepatitis C and hepatocellular carcinoma.
Sufficient evidence has accumulated that chronic infection with HCV substantially increases the risk of HCC, particularly in the presence of cirrhosis. HCV appears to represent a major underlying cause of HCC in southern Europe and Japan, regions where HCC incidence is intermediate, whereas its impact is smaller in sub-Saharan Africa and China, where HBV-related HCC predominates, and in the developed western world, where the majority of cases of HCC are associated with cirrhosis of unknown etiology.
Di Bisceglie
A M
AM
Department of Internal Medicine, St Louis University Health Sciences Center, MO 63104, USA.
D006528:Carcinoma, Hepatocellular / Q000209:etiology*; D002908:Chronic Disease; D006526:Hepatitis C / Q000150:complications*; D006801:Humans; D008113:Liver Neoplasms / Q000209:etiology*; D012307:Risk Factors