title: Motor neuron disease (amyotrophic lateral sclerosis) arising from longstanding primary lateral sclerosis.
abstract: Three men were initially diagnosed as having primary lateral sclerosis (PLS), but eventually developed amyotrophic lateral sclerosis (ALS) after 7.5, 9, and at least 27 years. Non-familial ALS and PLS might be different manifestations of a single disease or constitute completely distinct entities. The clinical diagnosis of PLS predicts a median survival that is four to five times longer than in ALS.
authors.affiliation: Department of Neurology, Oudenryn Hospital, Utrecht, The Netherlands.
authors.forename: R P
authors.initials: RP
authors.lastname: Bruyn
authors.forename: J H
authors.initials: JH
authors.lastname: Koelman
authors.forename: D
authors.initials: D
authors.lastname: Troost
authors.forename: J M
authors.initials: JM
authors.lastname: de Jong
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000150:complications / Q000209:etiology / Q000473:pathology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D013116:Spinal Cord / Q000473:pathology; D013997:Time Factors