Study of liver function in infants with atopic dermatitis using the 13C-methacetin breath test.
Serum glutamic-oxaloacetic transaminase (GOT) levels were determined in 214 infants (133 males and 81 females) with atopic dermatitis during their first visit to the Department of Allergy, National Children's Hospital, Tokyo, Japan. Compared with the normal hospital range, their levels were found to be significantly higher, a tendency which was more conspicuous in lower age groups. We carried out a 13C-methacetin breath test (MBT), administering the stable-isotope-labeled compound to 11 children with higher serum GOT values and 5 within the normal range to investigate hepatic metabolism of methacetin in infants with atopic dermatitis. 13C-methacetin was given orally, and the 13CO2 level in the breath was determined immediately before and after administration, by mass spectrometry. Compared to the normal controls, the atopic infants demonstrated significantly lower 13CO2 peak excretion and delayed peak time. The clearance rate of 13CO2 was also decreased. These results suggest some relationship between atopic dermatitis and liver function in infants.
Iikura
Y
Y
Department of Allergy and Immunology, National Children's Hospital, Tokyo, Japan.
Iwasaki
A
A
Tsubaki
T
T
Akasawa
A
A
Onda
T
T
Katsunuma
T
T
Miura
K
K
Ebisawa
M
M
Saito
H
H
Koya
N
N
D000081:Acetamides / Q000493:pharmacokinetics; D000410:Alanine Transaminase / Q000097:blood; D001219:Aspartate Aminotransferases / Q000097:blood; D001944:Breath Tests; D002247:Carbon Isotopes; D003876:Dermatitis, Atopic / Q000209:etiology / Q000503:physiopathology*; D004485:Eczema / Q000503:physiopathology; D005260:Female; D005512:Food Hypersensitivity / Q000503:physiopathology*; D006801:Humans; D007223:Infant; D007225:Infant Food / Q000009:adverse effects*; D007408:Intestinal Absorption; D008111:Liver Function Tests; D008297:Male; D013058:Mass Spectrometry; D008657:Metabolic Clearance Rate
D000081:Acetamides; D002247:Carbon Isotopes; C035495:methacetin; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase