IgE antibodies to tetanus toxoid in relation to atopy.
In approximately 25% of subjects receiving tetanus booster immunization (4 study groups A-D with n = 6, 25, 50 and 240, respectively; age 18-40 years for groups A-C, age 2 for group D), substantial IgE antibody levels were found. In groups A and B, sequential serum samples were available for analysis. The IgE response peaked before the IgG response and was often higher at week 1 than at week 2. The 6 subjects in group A (military recruits) received 2 booster injections. At the time of the second injection, 2 subjects had a very high IgE antibody titre (as well as a high IgG antibody titre), but no signs of an allergic reaction were noted. A significant association with atopy-related factors was found, but many apparently non-atopic subjects developed IgE antibodies.
Aalberse
R C
RC
Department of Allergy, CLB, Amsterdam, The Netherlands.
van Ree
R
R
Danneman
A
A
Wahn
U
U
D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D015331:Cohort Studies; D004168:Diphtheria Toxoid / Q000276:immunology; D005858:Germany / Q000453:epidemiology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics / Q000276:immunology*; D007117:Immunization, Secondary / Q000009:adverse effects; D007073:Immunoglobulin E / Q000097:blood / Q000276:immunology*; D007074:Immunoglobulin G / Q000097:blood; D017056:Medical Laboratory Personnel; D008875:Middle Aged; D008889:Military Personnel; D011852:Radioallergosorbent Test; D013745:Tetanus Toxoid / Q000009:adverse effects / Q000276:immunology*
D004168:Diphtheria Toxoid; D007074:Immunoglobulin G; D013745:Tetanus Toxoid; D007073:Immunoglobulin E