High-resolution mapping of SNCA encoding alpha-synuclein, the non-A beta component of Alzheimer's disease amyloid precursor, to human chromosome 4q21.3-->q22 by fluorescence in situ hybridization.
The human alpha-synuclein gene (SNCA) was previously identified as the non-A beta component of Alzheimer's disease amyloid precursor (NACP). A cosmid clone containing this gene has been isolated and mapped by FISH and high-resolution fluorescence banding to human chromosome 4q21.3-->q22.
Shibasaki
Y
Y
MRC Human Genetics Unit, Edinburgh, Scotland, UK.
Baillie
D A
DA
St Clair
D
D
Brookes
A J
AJ
D000682:Amyloid / Q000235:genetics*; D002874:Chromosome Mapping; D002894:Chromosomes, Human, Pair 4; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009419:Nerve Tissue Proteins / Q000235:genetics*; D000072002:Prion Proteins; D011328:Prions; D011498:Protein Precursors / Q000235:genetics*; D051843:Synucleins; D051844:alpha-Synuclein
D000682:Amyloid; D009419:Nerve Tissue Proteins; C512656:PRNP protein, human; D000072002:Prion Proteins; D011328:Prions; D011498:Protein Precursors; C497604:SNCA protein, human; D051843:Synucleins; D051844:alpha-Synuclein