[Protective action of phenothiazine derivatives in toxic edema-- swelling of the rat brain].
The mechanism of protective action of phenothiazine derivatives was studied by using a stochastic model of brain edema-swelling, which describes the relationship between various elements of vascular and cellular complexes in the nerve tissue. Each drug was found to have a preferable effect on particular morpho-functional structures: phenothiazine derivatives with a branched dialkylaminoalkyl chain exerted a protective action through the cellular complex and those with an unbranched chain affected through the vascular component of brain tissue. To increase a morphofunctional load on perivascular spaces is common to the agents in their mechanism of action.
Platonov
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IA
D000818:Animals; D001929:Brain Edema / Q000517:prevention & control*; D010640:Phenothiazines / Q000494:pharmacology*; D051381:Rats; D013269:Stochastic Processes
D010640:Phenothiazines