Transient expression of a brain/embryonic-type myosin heavy chain isoform (MIIB2) in regenerating rat liver.
The expressions of non-muscle-type (MIIA) and brain/embryonic-type (MIIB2) myosin heavy-chain isoforms in regenerating rat liver were examined. In regenerating liver after partial hepatectomy, the level of MIIA was nearly constant, while that of MIIB2 increased transiently. The level of MIIB2 was very low in normal livers, and increased gradually and then declined with a peak at the 4th day, when the regeneration was almost completed. The level of proliferating cell nuclear antigen was highest at the 2nd day. Serine dehydratase activity in the liver decreased on partial hepatectomy, began to increase at the 5th day, and reached 71% of the control at the 7th day. These results suggest that MIIB2 plays a role in reconstruction or differentiation of the regenerating tissues rather than in proliferation of hepatocytes.
Kimura
A
A
Department of Legal Medicine, Wakayama Medical College.
Yamaguchi
K
K
Ikeda
H
H
Yasuda
S
S
Matsumura
S
S
Tsuji
T
T
D000818:Animals; D002455:Cell Division / Q000502:physiology; D005260:Female; D007536:Isomerism; D008099:Liver / Q000033:anatomy & histology / Q000166:cytology / Q000378:metabolism*; D008115:Liver Regeneration / Q000502:physiology*; D018995:Myosin Heavy Chains / Q000378:metabolism / Q000502:physiology*; D009929:Organ Size / Q000502:physiology; D018809:Proliferating Cell Nuclear Antigen / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar
D018809:Proliferating Cell Nuclear Antigen; D018995:Myosin Heavy Chains