title: Detection of liver metastases: comparison of superparamagnetic iron oxide-enhanced and unenhanced MR imaging at 1.5 T with dynamic CT, intraoperative US, and percutaneous US.
abstract: OBJECTIVE
  To compare the sensitivities of superparamagnetic iron oxide-enhanced and unenhanced magnetic resonance (MR) imaging at 1.5 T with those of percutaneous ultrasound (US), intraoperative US (IOUS), and dynamic computed tomography (CT) in the preoperative assessment of metastatic liver disease.
  
  
  METHODS
  Eighteen patients with liver metastases who were candidates for curative surgery underwent presurgical imaging. Thirteen patients underwent surgery and IOUS after undergoing preoperative US, CT, and MR imaging.
  
  
  RESULTS
  In the preoperative imaging group, the standard of reference was the total number of lesions detected with any of the modalities. Superparamagnetic iron oxide-enhanced MR imaging was the most sensitive modality (99%). In the surgical group, the standard of reference was the total number of metastases identified at IOUS and pathologic examination. IOUS had the highest sensitivity (80%), followed by superparamagnetic iron oxide-enhanced MR imaging (56%).
  
  
  CONCLUSIONS
  Superparamagnetic iron oxide-enhanced high-field-strength MR imaging facilitates the preoperative evaluation of potentially curable metastatic liver disease; however, it is inferior to IOUS.
authors.affiliation: Department of Medical Radiology, University Hospital Zurich, Switzerland.
authors.forename: K D
authors.initials: KD
authors.lastname: Hagspiel
authors.forename: K F
authors.initials: KF
authors.lastname: Neidl
authors.forename: A C
authors.initials: AC
authors.lastname: Eichenberger
authors.forename: W
authors.initials: W
authors.lastname: Weder
authors.forename: B
authors.initials: B
authors.lastname: Marincek
mesh_terms: D015179:Colorectal Neoplasms / Q000473:pathology; D003287:Contrast Media; D003911:Dextrans; D005260:Female; D052203:Ferrosoferric Oxide; D006801:Humans; D007430:Intraoperative Care; D007483:Iothalamic Acid / Q000031:analogs & derivatives; D007501:Iron; D008099:Liver / Q000000981:diagnostic imaging / Q000473:pathology*; D008113:Liver Neoplasms / Q000175:diagnosis* / Q000556:secondary* / Q000601:surgery; D008279:Magnetic Resonance Imaging / Q000379:methods*; D058185:Magnetite Nanoparticles; D008297:Male; D008875:Middle Aged; D010087:Oxides; D011300:Preoperative Care; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed / Q000379:methods; D014463:Ultrasonography / Q000379:methods
chemical_list: D003287:Contrast Media; D003911:Dextrans; D058185:Magnetite Nanoparticles; D010087:Oxides; D007483:Iothalamic Acid; C002587:ioxitalamic acid; D007501:Iron; C065507:ferumoxides; D052203:Ferrosoferric Oxide