title: Interferon-gamma in the management of infectious diseases.
abstract: Interferon-gamma has pleiotropic adjuvant effects on host defenses. These effects have made interferon-gamma particularly useful for enhancing host defenses in patients with chronic granulomatous disease of childhood and thus for reducing the incidence of life-threatening infections in these patients. Increasingly, data suggest that interferon-gamma will be useful for treating infections characterized by intracellular persistence in macrophages, such as toxoplasmosis, leishmaniasis, and mycobacteriosis. Interferon-gamma is emerging as an important cytokine for use in the treatment of infectious diseases.
authors.affiliation: Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1504, USA.
authors.forename: J I
authors.initials: JI
authors.lastname: Gallin
authors.forename: J M
authors.initials: JM
authors.lastname: Farber
authors.forename: S M
authors.initials: SM
authors.lastname: Holland
authors.forename: T B
authors.initials: TB
authors.lastname: Nutman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007239:Infections / Q000188:drug therapy* / Q000382:microbiology; D007371:Interferon-gamma / Q000494:pharmacology / Q000627:therapeutic use*; D008969:Molecular Sequence Data; D010272:Parasitic Diseases / Q000188:drug therapy; D011506:Proteins / Q000187:drug effects
chemical_list: D011506:Proteins; D007371:Interferon-gamma