[Antimicrobial and antitrichomonal activity of 5-nitroimidazole derivatives in an in vitro experiment].
The comparative study on the antimicrobial activity of metronidazole and its complex with cobalt sulfate showed that the complex formation increased 2-4 times the metronidazole activity against elective anaerobes. The study of the drug action on Trichomonas spp. revealed that as a result of the complexing with cobalt sulfate the metronidazole efficacy against the Trichomonas strains isolated from the discharge of a female patient with metronidazole resistant trichomoniasis increased, the activating effect of the complex on the host cells being suggested.
Seleznev
A S
AS
Dmitriev
G A
GA
Bragina
E E
EE
Kaletina
N I
NI
Pavlova
L A
LA
Murza
Ia V
IaV
Abdumalikov
R A
RA
D003035:Cobalt / Q000737:chemistry*; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
D008795:Metronidazole; D003035:Cobalt; C026305:cobalt sulfate