title: Effects of high doses of oxytetracycline on metacarpophalangeal joint kinematics in neonatal foals.
abstract: Thirteen clinically normal Belgian-type foals were used to study the effects of high doses of oxytetracycline on metacarpophalangeal joint kinematics. Seven foals (treatment group) received 2 doses of oxytetracycline (3 g, IV). The first dose was given when foals were 4 days old; the second dose was given 24 hours later. Six foals (control group) received 2 doses of saline (0.9% NaCl) solution (15 ml, IV) at equivalent time periods. All foals were videotaped at a walk twice: immediately prior to the first treatment and 24 hours after the second treatment. The tapes were digitized, and metacarpophalangeal joint angle was measured along the palmar surface of the limb during 3 strides. The angular data were normalized for time, and data from the 3 strides were averaged to describe a representative stride. Repeated measures ANOVA was used to test for differences between groups and within groups over time. Values for stride duration, stance phase percentage, and minimum metacarpophalangeal joint angle obtained before treatment were not significantly different from values obtained after treatment. Maximum metacarpophalangeal joint angle, which occurred during the stance phase of the stride, and range of joint motion were significantly increased for foals in the treatment group, compared with foals in the control group.
authors.affiliation: Department of Veterinary Anesthesiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Canada.
authors.forename: C A
authors.initials: CA
authors.lastname: Kasper
authors.forename: H M
authors.initials: HM
authors.lastname: Clayton
authors.forename: A K
authors.initials: AK
authors.lastname: Wright
authors.forename: E V
authors.initials: EV
authors.lastname: Skuba
authors.forename: L
authors.initials: L
authors.lastname: Petrie
mesh_terms: D000818:Animals; D000831:Animals, Newborn / Q000502:physiology*; D005552:Forelimb; D005684:Gait / Q000187:drug effects*; D006736:Horses / Q000502:physiology*; D007596:Joints / Q000187:drug effects* / Q000502:physiology; D010118:Oxytetracycline / Q000494:pharmacology*; D014743:Videotape Recording
chemical_list: D010118:Oxytetracycline