title: Dietary flour supplementation decreases post-menopausal hot flushes: effect of soy and wheat.
abstract: Plants contain compounds with oestrogen-like action called phytoestrogens. Soy contains daidzin, a potent phytoestrogen, and wheat flour contains less potent enterolactones. We aimed to show in 58 postmenopausal women (age 54, range 30-70 years) with at least 14 hot flushes per week, that their daily diet supplemented with soy flour (n = 28) could reduce flushes compared with wheat flour (n = 30) over 12 weeks when randomised and double blind. Hot flushes significantly decreased in the soy and wheat flour groups (40% and 25% reduction, respectively < 0.001 for both) with a significant rapid response in the soy flour group in 6 weeks (P < 0.001) that continued. Menopausal symptom score decreased significantly in both groups (P < 0.05). Urinary daidzein excretion confirmed compliance. Vaginal cell maturation, plasma lipids and urinary calcium remained unchanged. Serum FSH decreased and urinary hydroxyproline increased in the wheat flour group.
authors.affiliation: Brighton Medical Clinic, Brighton, Vic., Australia.
authors.forename: A L
authors.initials: AL
authors.lastname: Murkies
authors.forename: C
authors.initials: C
authors.lastname: Lombard
authors.forename: B J
authors.initials: BJ
authors.lastname: Strauss
authors.forename: G
authors.initials: G
authors.lastname: Wilcox
authors.forename: H G
authors.initials: HG
authors.lastname: Burger
authors.forename: M S
authors.initials: MS
authors.lastname: Morton
mesh_terms: D000328:Adult; D000368:Aged; D004311:Double-Blind Method; D004968:Estrogens, Non-Steroidal / Q000008:administration & dosage*; D005260:Female; D005433:Flour; D005483:Flushing / Q000517:prevention & control*; D006801:Humans; D007529:Isoflavones; D008875:Middle Aged; D048789:Phytoestrogens; D028321:Plant Preparations; D017698:Postmenopause; D013025:Glycine max; D014908:Triticum
chemical_list: D004968:Estrogens, Non-Steroidal; D007529:Isoflavones; D048789:Phytoestrogens; D028321:Plant Preparations