title: Effects of local injection of corticosteroids on the healing of ligaments. A follow-up report.
abstract: One hundred and one skeletally mature New Zealand White rabbits were used to study the long-term effects of a single injection of corticosteroid on the biomechanical, histological, and biochemical properties of ligament-healing. Two steroid doses were studied, as previously described. The injections were made into a fascial pocket immediately after transection of the ligament. The animals were killed forty-two and eighty-four days after the injury. In our previous investigation, in which we examined the early (inflammatory and proliferative) phases of ligament-healing, the specimens that had been injected with a dose of steroids equivalent to that given to humans demonstrated significantly inferior biomechanical properties and histological organization relative to controls that had not received an injection. In the current study, we examined the later (remodeling and maturation) phases of ligament-healing and found that the tensile strength (the ultimate stress) of the specimens that had been injected with the steroids returned to a value that was equal to that of the controls that had not received an injection; however, the peak load of the specimens that had been injected with steroids remained inferior to that of the controls. This was accompanied by a lag in the histological maturation.
authors.affiliation: Department of Orthopaedics, Brown University School of Medicine, Rhode Island Hospital, Providence 02903, USA.
authors.forename: M E
authors.initials: ME
authors.lastname: Wiggins
authors.forename: P D
authors.initials: PD
authors.lastname: Fadale
authors.forename: M G
authors.initials: MG
authors.lastname: Ehrlich
authors.forename: W R
authors.initials: WR
authors.lastname: Walsh
mesh_terms: D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D001623:Betamethasone / Q000494:pharmacology*; D003094:Collagen / Q000096:biosynthesis; D005260:Female; D006614:Hindlimb / Q000293:injuries; D066298:In Vitro Techniques; D017888:Medial Collateral Ligament, Knee / Q000187:drug effects* / Q000293:injuries*; D011817:Rabbits; D013718:Tensile Strength / Q000187:drug effects; D013997:Time Factors; D014945:Wound Healing / Q000187:drug effects*
chemical_list: D000893:Anti-Inflammatory Agents; D003094:Collagen; D001623:Betamethasone