Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK.
We have mapped the gene encoding the murine RYK growth factor receptor protein tyrosine kinase by genetic linkage analysis with recombinant inbred strains of mouse. Two distinct Ryk loci (Ryk-1 and Ryk-2) were identified. Ryk-1 mapped to Chromosome (Chr) 9, whereas Ryk-2 mapped to Chr 12. A similar arrangement of RYK-related loci was previously determined in the human. Synteny has already been established between murine Chr 9 in the region of Ryk-1, and human chromosome 3q11-12, the location of the human RYK-1 gene. However, the Ryk-2/RYK-2 loci on murine Chr 12 and human Chr 17p13.3 define a new region of synteny.
Gough
N M
NM
Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
Rakar
S
S
Hovens
C M
CM
Wilks
A
A
D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D008040:Genetic Linkage; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics*
D011956:Receptors, Cell Surface; C080836:RYK protein, human; D020794:Receptor Protein-Tyrosine Kinases