Mechanisms of persistent airway inflammation in asthma. A role for T cells and T-cell products.
The role of T cells in human allergic inflammation is just beginning to be understood. However, the data presented indicate how the T cell may be a pivotal cell to direct features of allergic inflammation in asthma, how the T cell may be able to transfer hyperresponsiveness, which is a feature of bronchial asthma, what some of the genetic factors are that may determine this process, and how an important precipitant of asthma, viral respiratory infections, may participate in this process. Its cells are isolated from patients with asthma and studied for their ability to generate proinflammatory failure. An expanded understanding of the chronic, persistent nature of asthma will become apparent.
Busse
W W
WW
Coffman
R L
RL
Gelfand
E W
EW
Kay
A B
AB
Rosenwasser
L J
LJ
D000818:Animals; D001249:Asthma / Q000235:genetics / Q000276:immunology* / Q000503:physiopathology; D016535:Bronchial Hyperreactivity / Q000276:immunology* / Q000503:physiopathology; D006801:Humans; D012141:Respiratory Tract Infections / Q000821:virology; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*; D014777:Virus Diseases / Q000276:immunology