title: Antiinflammatory mechanism of cordiachromene A action.
abstract: The mechanism of antiinflammatory action of cordiachromene A, isolated from the chloromethylenic extract of the ascidian Aplidium antillense or chemically synthesized, was studied using different in vivo and in vitro inhibition tests on enzymes of the cyclooxygenase cascade. Cordiachromene A inhibits prostacyclin synthesis and arachidonic acid metabolism but not phospholipase A2 and peroxidase. The mechanism of action, already known to be stereospecific, operates by cyclooxygenase inhibition.
authors.affiliation: SMAB, Université de Nantes, Faculté de Pharmacie, France.
authors.forename: A F
authors.initials: AF
authors.lastname: Benslimane
authors.forename: Y F
authors.initials: YF
authors.lastname: Pouchus
authors.forename: J F
authors.initials: JF
authors.lastname: Verbist
authors.forename: J Y
authors.initials: JY
authors.lastname: Petit
authors.forename: J D
authors.initials: JD
authors.lastname: Brion
authors.forename: L
authors.initials: L
authors.lastname: Welin
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D016718:Arachidonic Acid / Q000037:antagonists & inhibitors; D002867:Chromones / Q000494:pharmacology*; D016861:Cyclooxygenase Inhibitors / Q000494:pharmacology; D011464:Epoprostenol / Q000037:antagonists & inhibitors*; D006801:Humans; D009195:Peroxidase / Q000378:metabolism; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D002867:Chromones; D016861:Cyclooxygenase Inhibitors; D016718:Arachidonic Acid; C042676:2-methyl-2-(4-methylpent-3-enyl)-2H-chromen-6-ol; D011464:Epoprostenol; D009195:Peroxidase; D010741:Phospholipases A; D054467:Phospholipases A2