title: Cardiovascular and neuroendocrine responses during acute stress induced by different types of dental treatment.
abstract: Patients demonstrate a physiological stress response during dental checkups and treatment. Local anesthesia and tooth extraction activate the adrenal cortex to produce cortisol. Changes in adrenaline or noradrenaline concentrations have been reported in plasma and urine after drilling and filling or extraction, and anticipation of a dental checkup increases blood pressure. Both diastolic and systolic blood pressure rise still further during restorative treatment without local anaesthesia and during extraction. In a study by the same authors, no significant changes in blood pressure were observed during restorative treatment with local anaesthesia, which suggests that the pain experienced by the patient contributes to the rise in blood pressure. Dentists must be aware that this increased blood pressure may induce cardiovascular complications during dental therapy.
authors.affiliation: Department of General Pathology and Internal Medicine, Academic Centre for Dentistry Amsterdam, The Netherlands.
authors.forename: H S
authors.initials: HS
authors.lastname: Brand
authors.forename: R A
authors.initials: RA
authors.lastname: Gortzak
authors.forename: C C
authors.initials: CC
authors.lastname: Palmer-Bouva
authors.forename: R E
authors.initials: RE
authors.lastname: Abraham
authors.forename: L
authors.initials: L
authors.lastname: Abraham-Inpijn
mesh_terms: D001794:Blood Pressure / Q000502:physiology*; D016854:Dental Anxiety / Q000150:complications; D003729:Dental Care / Q000009:adverse effects*; D017742:Dental Care for Chronically Ill; D003737:Dental Cavity Preparation / Q000009:adverse effects; D003793:Dental Restoration, Permanent / Q000009:adverse effects; D004837:Epinephrine / Q000097:blood / Q000652:urine; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D006973:Hypertension / Q000209:etiology; D009490:Neurosecretory Systems / Q000502:physiology; D009638:Norepinephrine / Q000097:blood / Q000652:urine; D010146:Pain / Q000503:physiopathology; D013312:Stress, Physiological / Q000150:complications / Q000209:etiology / Q000503:physiopathology*; D014081:Tooth Extraction / Q000009:adverse effects
chemical_list: D006854:Hydrocortisone; D009638:Norepinephrine; D004837:Epinephrine