[Effect of EPA-rich fat emulsion on the permeability of the rat intestinal mucosa].
TR8030 (TR) which was EPA (omega-3 fatty acid)-rich fat emulsion and Intralipos (IL) which contained much omega-6 fatty acids were administered intraperitoneally to rats to evaluate their effects on the intestinal mucosa by determining changes in the fatty acid composition of mucosal phospholipid, intra- and intercellular intestinal mucosal permeability, and thickness of the unstirred water layer, one of the intestinal defense functions. The content of EPA in the intestinal mucosa was higher in the TR group than in the control group, and there was a change in intercellular permeability. The unstirred water layer was thinner in the TR group than in the IL group. Based on the results presented, it may be concluded that EPA-rich emulsion affects the fatty acid composition of intestinal mucosa phospholipid, mucosal intercellular permeability, and mucosal defense function.
Shimizu
N
N
4th Department of Internal Medicine, Tokyo Medical College.
D000818:Animals; D002463:Cell Membrane Permeability; D015118:Eicosapentaenoic Acid / Q000493:pharmacokinetics*; D005217:Fat Emulsions, Intravenous / Q000493:pharmacokinetics*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D005217:Fat Emulsions, Intravenous; D015118:Eicosapentaenoic Acid