title: [The value of clinical and chemical laboratory follow-up parameters in neuroborreliosis].
abstract: Whereas the diagnosis of acute neuroborreliosis by considering clinical and cerebrospinal fluid parameters is very reliable chronic neuroborreliosis is an excluding diagnosis. The clinical symptoms are uncharacteristic, and there is no reliable laboratory test permitting a safe diagnosis. Serological evidence of antibodies is no sign of activity of disease. Development of chronic infection after adequate treatment of acute neuroborreliosis seems to be very rare. We reinvestigated 15 patients half a year after antibiotic therapy of acute neuroborreliosis with regard to clinical and laboratory parameters. Most patients had a continuous intrathecal IgG antibody production against Borrelia burgdorferi, whereas no clinical signs of chronic neuroborreliosis existed. The antibody production against Borrelia burgdorferi must not be regarded as a sign of chronic infection.
authors.affiliation: Klinik für Neurologie und Neurophysiologie im Städt. Klinikum Fulda.
authors.forename: J
authors.initials: J
authors.lastname: Koch
authors.forename: J M
authors.initials: JM
authors.lastname: Klotz
authors.forename: H D
authors.initials: HD
authors.lastname: Langohr
mesh_terms: D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000134:cerebrospinal fluid*; D015748:Borrelia burgdorferi Group / Q000276:immunology*; D002443:Ceftriaxone / Q000627:therapeutic use; D002908:Chronic Disease; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007074:Immunoglobulin G / Q000134:cerebrospinal fluid; D008193:Lyme Disease / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D008297:Male; D016920:Meningitis, Bacterial / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D010400:Penicillin G / Q000627:therapeutic use; D011843:Radiculopathy / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D007074:Immunoglobulin G; D002443:Ceftriaxone; D010400:Penicillin G