title: [Sepsis in children with malignant neoplasia, equipped with a Broviac-type venous catheter].
abstract: Indwelling central venous catheters obviate many problems in the care of children with malignancies, but they also are a well-known source of infection. We are reviewed the history of 584 Broviac catheters inserted from January 1984 to December 1991, in 475 children with cancer in order to assess the etiology of bacteremias, their association with neutropenia and their relationship with the presence of the catheters. The overall duration-time of the catheters, employed for blood tests, drug and blood infusions and parenteral nutrition, was 1-835 days (median 263, mean 186). Total catheter courses was 108.678 days. In this period 226 episodes of sepsis were observed in 180 patients: 157 in neutropenic patients and 69 in non neutropenic. Catheter related bacteremias were diagnosed in 65/226 episodes (29%): 23 (35%) were observed in neutropenic patients and 42 (65%) in non neutropenic (P < 0.005). Gram-positive pathogens were isolated in 28/65 (43%) episodes, Gram-negatives in 15/65 (23%), fungi in 9/65 (14%), and the remaining 13 (20%) were polymicrobial. In the last years we observed an increase of catheter related bacteremias due to Gram-negative rods no change was observed in pathogens causing catheters unrelated bacteremias. The high incidence of catheters related bacteremias in non neutropenic, non hospitalized patients, stress on the home-care of the catheters; a high level of suspicion of Gram-negative infections should be maintained in cancer patients with an indwelling central venous catheters.
authors.affiliation: Divisione di Ematologia ed Oncologia Pediatrica, Istituto G. Gaslini di Genova, Italia.
authors.forename: A
authors.initials: A
authors.lastname: Garaventa
authors.forename: E
authors.initials: E
authors.lastname: Castagnola
authors.forename: S
authors.initials: S
authors.lastname: Dallorso
authors.forename: G
authors.initials: G
authors.lastname: Dini
authors.forename: D
authors.initials: D
authors.lastname: Trucco
authors.forename: O
authors.initials: O
authors.lastname: Vianello
authors.forename: G
authors.initials: G
authors.lastname: Carrega
authors.forename: P
authors.initials: P
authors.lastname: Cuneo
authors.forename: P
authors.initials: P
authors.lastname: Buffa
authors.forename: P
authors.initials: P
authors.lastname: Magillo
mesh_terms: D000970:Antineoplastic Agents / Q000008:administration & dosage; D002405:Catheterization, Central Venous / Q000009:adverse effects* / Q000295:instrumentation; D002408:Catheters, Indwelling / Q000009:adverse effects*; D002648:Child; D005260:Female; D006090:Gram-Negative Bacteria / Q000302:isolation & purification; D006094:Gram-Positive Bacteria / Q000302:isolation & purification; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D009369:Neoplasms / Q000628:therapy*; D009503:Neutropenia / Q000209:etiology; D010288:Parenteral Nutrition / Q000295:instrumentation; D018805:Sepsis / Q000209:etiology* / Q000382:microbiology
chemical_list: D000970:Antineoplastic Agents