title: The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q.
abstract: Brain factor-1 (BF-1) is a member of the fork head gene family which shows expression restricted to the neurons of the developing telencephalon in rodents and man. We have isolated a second human gene (HBF-2), which is also strongly expressed in embryonic brain and has very high homology to both the rat and human brain factor-1 genes and the retroviral oncogene qin. The HBF-2 cDNA was isolated from a human fetal brain expression library and contains a putative open reading frame of 479 amino acids. The HBF-2 gene is strongly expressed in fetal brain and also with lower levels of expression in several adult tissues. At the genomic level the gene for HBF-1 contains an 500 bp intron situated between the DNA binding domain II and the fork head domain while that of HBF-2 is intronless. The two genes are clustered on human chromosome 14q11-13.
authors.affiliation: Institut für Humangenetik, Göttingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Wiese
authors.forename: D B
authors.initials: DB
authors.lastname: Murphy
authors.forename: A
authors.initials: A
authors.lastname: Schlung
authors.forename: P
authors.initials: P
authors.lastname: Burfeind
authors.forename: D
authors.initials: D
authors.lastname: Schmundt
authors.forename: V
authors.initials: V
authors.lastname: Schnülle
authors.forename: M G
authors.initials: MG
authors.lastname: Mattei
authors.forename: U
authors.initials: U
authors.lastname: Thies
mesh_terms: D000595:Amino Acid Sequence; D001483:Base Sequence; D002883:Chromosomes, Human, Pair 14 / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000235:genetics*; D051858:Forkhead Transcription Factors; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016415:Sequence Alignment; D013687:Telencephalon / Q000737:chemistry*
chemical_list: D004268:DNA-Binding Proteins; C090173:FOXG1 protein, human; D051858:Forkhead Transcription Factors; D009419:Nerve Tissue Proteins