Atanine (3-dimethylallyl-4-methoxy-2-quinolone), an alkaloid with anthelmintic activity from the Chinese medicinal plant, Evodia rutaecarpa.
Phytochemical studies using a range of chromatographic and spectroscopic techniques coupled with in vitro bioassays against larval Schistosoma mansoni, L4 larvae of Ostertagia circumcincta, and adults and larvae of Caenorhabditis elegans have led to the isolation of an active anthelmintic compound in the Chinese medicinal plant Evodia rutaecarpa (Rutaceae) and its identification as atanine (3-dimethylallyl-4-methoxy-2-quinolone). Atanine has not previously been found to possess antiparasitic activity.
Perrett
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Whitfield
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D000818:Animals; D000871:Anthelmintics / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology; D017173:Caenorhabditis elegans / Q000187:drug effects*; D007814:Larva; D008516:Medicine, Chinese Traditional; D010028:Ostertagia / Q000187:drug effects*; D010946:Plants, Medicinal / Q000737:chemistry*; D015363:Quinolones / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D012550:Schistosoma mansoni / Q000187:drug effects*
D000871:Anthelmintics; D015363:Quinolones; C094654:atanine