title: Acute myocardial infarction--the angiographic picture: new insights into the pathogenesis of myocardial infarction.
abstract: The angiographic appearance of the coronary arteries were examined in 302 patients with stable angina pectoris and compared to 308 patients with acute myocardial infarction, who received high-dose intravenous thrombolytic therapy, in order to elucidate the underlying angiopathological picture in the two diseases. In each group coronary lesions were present in proximal segments of the arteries and were closely related to bifurcations. Lesions were more extensively distributed in the coronary tree in patients with stable angina and they had an average of 5.4 lesions per patient, compared to the acute myocardial infarction group who had only 2.4 lesions. Also, in the acute myocardial infarction patients, four-fifths of the culprit arteries were patent, 104 (34%) had a ruptured plaque, 22 (7%) had an ulcerated plaque and in 190 (62%) the lesions were eccentric. The study shows that patients with myocardial infarction who are suitable for thrombolysis have a unique coronary angiographic picture and the acute episode is caused by sudden rupture of a localized atheromatous plaque which initiates an obstructive thrombotic cascade.
authors.affiliation: Cardiology Department, Hadassah University Hospital, Jerusalem, Israel.
authors.forename: Y
authors.initials: Y
authors.lastname: Rozenman
authors.forename: S
authors.initials: S
authors.lastname: Rosenheck
authors.forename: H
authors.initials: H
authors.lastname: Nassar
authors.forename: S
authors.initials: S
authors.lastname: Welber
authors.forename: D
authors.initials: D
authors.lastname: Sapoznikov
authors.forename: C
authors.initials: C
authors.lastname: Lotan
authors.forename: M
authors.initials: M
authors.lastname: Mosseri
authors.forename: A T
authors.initials: AT
authors.lastname: Weiss
authors.forename: M S
authors.initials: MS
authors.lastname: Gotsman
mesh_terms: D000787:Angina Pectoris / Q000000981:diagnostic imaging / Q000209:etiology / Q000473:pathology; D017023:Coronary Angiography; D003324:Coronary Artery Disease / Q000150:complications / Q000000981:diagnostic imaging*; D003328:Coronary Thrombosis / Q000150:complications / Q000000981:diagnostic imaging* / Q000188:drug therapy; D003331:Coronary Vessels / Q000473:pathology*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging* / Q000209:etiology* / Q000473:pathology; D015912:Thrombolytic Therapy