title: Oral hyposensitization to nickel allergy: preliminary clinical results.
abstract: Fifty-one patients presenting a dermatological allergy (erythema, urticaria, angioedema, contact dermatitis) to nickel were treated over 3 years with oral doses of 0.1 ng nickel sulfate per day, following a low-nickel diet. Diagnostic tests comprised patch and oral provocation tests. In 7 cases, the treatment was interrupted because of symptom reactivation, and in 14 cases for other reasons. Among the 30 cases who went through the whole follow-up, symptomatology totally disappeared in 29 cases, and a partial alleviation was achieved in 1 case after 1 year of treatment. Oral provocation tests with these 30 patients showed an overall increase of tolerance. Patch tests showed no variation in 20 cases, a diminution in 5, and were negative in 5. Although the study was not conducted double blind, the results of this attempt to cure nickel allergy are statistically significant.
authors.affiliation: Laboratoire de Recherches Marseille, France.
authors.forename: R C
authors.initials: RC
authors.lastname: Panzani
authors.forename: D
authors.initials: D
authors.lastname: Schiavino
authors.forename: E
authors.initials: E
authors.lastname: Nucera
authors.forename: S
authors.initials: S
authors.lastname: Pellegrino
authors.forename: G
authors.initials: G
authors.lastname: Fais
authors.forename: G
authors.initials: G
authors.lastname: Schinco
authors.forename: G
authors.initials: G
authors.lastname: Patriarca
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D003888:Desensitization, Immunologic; D004032:Diet; D003875:Drug Eruptions / Q000178:diet therapy / Q000209:etiology / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009532:Nickel / Q000008:administration & dosage / Q000627:therapeutic use*; D010328:Patch Tests; D016896:Treatment Outcome
chemical_list: C029938:nickel sulfate; D009532:Nickel