Immunoreactive inhibin concentrations in human gonads and adrenals during the first years of life.
We determined immunoreactive inhibin (irINH) concentration in the gonads and adrenals of healthy children (0-75 months) who had died suddenly. Testicular irINH peaked in the first 3 months of life with a significant drop in the 4th month (p < 0.05). In ovarian tissue, irINH was significantly lower than in the testes (p < 0.001) with highest levels during the first 4 months of life parallel to the highest estradiol concentrations. A significant correlation between gonadal testosterone/estradiol and irINH was observed. In adrenal tissue, irINH levels were significantly lower than in the gonads without sex-specific differences.
Brennemann
W
W
Department of Clinical Biochemistry, University of Bonn, Germany.
Klingmüller
D
D
Eter
N
N
Bidlingmaier
F
F
D000311:Adrenal Glands / Q000254:growth & development* / Q000378:metabolism*; D000735:Androstenedione / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007265:Inhibins / Q000378:metabolism*; D008297:Male; D010053:Ovary / Q000254:growth & development* / Q000378:metabolism*; D012727:Sex Characteristics; D013737:Testis / Q000254:growth & development* / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism
D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol; D007265:Inhibins