title: Neutralization of feline immunodeficiency virus by polyclonal feline antibody: simultaneous involvement of hypervariable regions 4 and 5 of the surface glycoprotein.
abstract: Sites involved in antibody-mediated neutralization of feline immunodeficiency virus were mapped by reciprocal exchange of envelope fragments or amino acids between molecular clones of feline immunodeficiency virus with different susceptibilities to neutralization by a polyclonal cat serum. Combinations of mutations within HV-4 or within HV-4 and HV-5 changed the susceptibility of the viruses to neutralizing antibody.
authors.affiliation: Institute of Virology, Erasmus University Rotterdam, The Netherlands.
authors.forename: K H
authors.initials: KH
authors.lastname: Siebelink
authors.forename: W
authors.initials: W
authors.lastname: Huisman
authors.forename: J A
authors.initials: JA
authors.lastname: Karlas
authors.forename: G F
authors.initials: GF
authors.lastname: Rimmelzwaan
authors.forename: M L
authors.initials: ML
authors.lastname: Bosch
authors.forename: A D
authors.initials: AD
authors.lastname: Osterhaus
mesh_terms: D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology*; D002460:Cell Line; D003001:Cloning, Molecular; D004285:Dogs; D007106:Immune Sera; D016089:Immunodeficiency Virus, Feline / Q000276:immunology*; D008562:Membrane Glycoproteins / Q000276:immunology*; D009500:Neutralization Tests; D017354:Point Mutation; D014764:Viral Proteins / Q000276:immunology*
chemical_list: D000914:Antibodies, Viral; D007106:Immune Sera; D008562:Membrane Glycoproteins; D014764:Viral Proteins