title: Phylogeny of lymphocyte heterogeneity: cytotoxic activity of channel catfish peripheral blood leukocytes directed against allogeneic targets.
abstract: Channel catfish peripheral blood contains leukocytes that function as cytotoxic effectors directed against a variety of long-term cultured allogeneic, but not xenogeneic, targets. These effector cells are probably distinct from macrophages, B cells, and nonspecific cytotoxic cells. The cytotoxic activity of these effector cells was inhibited with monoclonal antibody 1H5. Although this reagent appears to react with a catfish cell surface molecule akin to the integrin LFA-1 present on the surface of nearly all leukocytes, it does not clarify the question as to whether or not these effectors are related to T cells.
authors.affiliation: Department of Microbiology, University of Mississippi Medical Center, Jackson 39216, USA.
authors.forename: S H
authors.initials: SH
authors.lastname: Yoshida
authors.forename: T B
authors.initials: TB
authors.lastname: Stuge
authors.forename: N W
authors.initials: NW
authors.lastname: Miller
authors.forename: L W
authors.initials: LW
authors.lastname: Clem
mesh_terms: D000818:Animals; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D007059:Ictaluridae / Q000097:blood / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D016131:Lymphocyte Subsets; D010802:Phylogeny; D013045:Species Specificity