title: [Obstructive-restrictive pulmonary syndrome as long-term side effect of bone marrow transplantation in thalassemia major. Prognostic and therapeutic problems].
abstract: The Authors describe a case of severe obstructive-restrictive pulmonary disease following bone marrow transplantation in a Cooley disease affected child. It is an uncommon complication, strictly related to chronic Graft Versus Host Disease (c-GVHD) and for the prevention of which it is may be necessary a more aggressive c-GVHD immunosuppressive therapy. Bone marrow transplantation represents today the only actual resolutive therapy for thalassemia major; so the number of transplantations and related undesirable effects are thought to be increasing in the future. Therefore, a permanent Centre for Control of the complications can be useful for the improvement of survival and quality of life in these patients.
authors.affiliation: Divisione di Pediatria-Ospedale Civile, Desio (MI), Italia.
authors.forename: G
authors.initials: G
authors.lastname: La Placa
authors.forename: C
authors.initials: C
authors.lastname: Uderzo
authors.forename: M
authors.initials: M
authors.lastname: Andreotti
authors.forename: M
authors.initials: M
authors.lastname: Urbano
authors.forename: F
authors.initials: F
authors.lastname: Petroni
authors.forename: E
authors.initials: E
authors.lastname: Corbella
mesh_terms: D016026:Bone Marrow Transplantation / Q000009:adverse effects*; D002648:Child; D006087:Graft vs Host Reaction / Q000187:drug effects*; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D008173:Lung Diseases, Obstructive / Q000209:etiology* / Q000628:therapy; D008297:Male; D011379:Prognosis; D013577:Syndrome; D017086:beta-Thalassemia / Q000150:complications* / Q000628:therapy
chemical_list: D007166:Immunosuppressive Agents