title: Exhaled flow monitoring can detect bronchial flap-valve obstruction in a mechanical lung model.
abstract: Flap-valve obstruction to expiratory flow (V) in a major bronchus can result from inspissated secretions, blood, or foreign body. During inhalation, increasing airway caliber preserves inspired V past the obstruction; during exhalation, decreasing airway diameter causes airflow obstruction and even frank gas trapping. We reasoned that the resultant sequential, biphasic exhalation of the lungs would be best detected by measuring exhaled V versus time. Accordingly, we designed an airway obstruction element in a mechanical lung model to examine flap-valve bronchial obstruction. A mechanical lung simulator was ventilated with a pressure-limited flow generator, where f = 10/min, tidal volume = 850 mL, and respiratory compliance = 40 mL/cm H2O. Airway V (pneumotachometer) and pressure (P) were digitally sampled for 1 min. Then, the circumference of the diaphragm in a respiratory one-way valve was trimmed to generate unidirectional resistance to expiratory V. Measurement sequences were repeated after this flap-valve was interposed in the right "main-stem bronchus." Integration of airway V versus time generated changes in lung volume. During flap-valve obstruction of the right bronchus, the V-time plot revealed preservation of peak expired flow from the normal lung, followed by retarded and decreased flow from the obstructed right lung. Gas trapping of the obstructed lung occurred during conditions of decreased expiratory time and increased expiratory resistance. Airway P could not differentiate between bronchial and tracheal flap-valve obstruction because P decreased abruptly in both conditions. The flow-volume loop displayed less distinctive changes than the flow-time plot, in part because the flow-volume loop was data (flow) plotted against its time integral (volume), with loss of temporal data. In this mechanical lung model, we conclude that bronchial flap-valve obstruction was best detected by the flow-time plot, which could measure the sequential emptying of the lungs.
authors.affiliation: Department of Anesthesiology, University of California at Irvine Medical Center, Orange, CA 92613, USA.
authors.forename: P H
authors.initials: PH
authors.lastname: Breen
authors.forename: E R
authors.initials: ER
authors.lastname: Serina
authors.forename: S J
authors.initials: SJ
authors.lastname: Barker
mesh_terms: D000402:Airway Obstruction / Q000473:pathology / Q000503:physiopathology*; D000403:Airway Resistance; D001980:Bronchi / Q000473:pathology / Q000503:physiopathology*; D004867:Equipment Design; D006801:Humans; D001239:Inhalation; D008168:Lung / Q000503:physiopathology*; D008170:Lung Compliance; D008449:Maximal Expiratory Flow-Volume Curves; D008961:Models, Structural; D008991:Monitoring, Physiologic; D010366:Peak Expiratory Flow Rate; D011312:Pressure; D012123:Pulmonary Ventilation; D012815:Signal Processing, Computer-Assisted; D013990:Tidal Volume; D014132:Trachea / Q000473:pathology / Q000503:physiopathology