Polyanion inhibitors of human immunodeficiency virus and other viruses. 1. Polymerized anionic surfactants.
A series of polyanionic compounds was synthesized and evaluated for their activity against human immunodeficiency virus (HIV-1, HIV-2) and various other RNA and DNA viruses. Several compounds, i.e., 2p, 3p, 8p, 13p, 14p, 15p, 17p, 18p, and 19p, proved active against HIV-1 within the concentration range of 0.1-3 micrograms/mL while not being toxic to the host cells (CEM, MT-4) at concentrations up to 100 micrograms/mL or higher. As a rule, these polyanionic compounds proved also active, albeit at somewhat higher concentrations than those required for HIV-1 inhibition, against a number of other enveloped viruses, including HIV-2, human cytomegalovirus, influenza A virus, respiratory syncytial virus, and arenaviruses (Junin and Tacaribe). Among the most potent HIV-1 inhibitors ranked compounds 18p and 19p, the sodium salts of N-methylamides obtained by polymerization of monomers prepared starting from 10-undecenoyl chloride and omega-aminoalkanoic acids.
Leydet
A
A
Laboratoire de Chimie Organique Physique, Université Montpellier II, France.
Barthelemy
P
P
Boyer
B
B
Lamaty
G
G
Roque
J P
JP
Bousseau
A
A
Evers
M
M
Hénin
Y
Y
Snoeck
R
R
Andrei
G
G
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D002460:Cell Line; D004267:DNA Viruses / Q000187:drug effects*; D015497:HIV-1 / Q000187:drug effects*; D015498:HIV-2 / Q000187:drug effects*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D000071228:Polyelectrolytes; D011108:Polymers; D012328:RNA Viruses / Q000187:drug effects*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013501:Surface-Active Agents / Q000737:chemistry / Q000494:pharmacology*
D000998:Antiviral Agents; D000071228:Polyelectrolytes; D011108:Polymers; D013501:Surface-Active Agents