[Pentoxifylline inhibits secretion of O2- and TNF-alpha by alveolar macrophages in patients with sarcoidosis].
Reactive oxygen species (ROS) and cytokines like tumor necrosis factor-alpha (TNF-alpha) play a crucial role as inflammatory mediators in pulmonary sarcoidosis. We examined the antiinflammatory effect of pentoxifylline (POF) on alveolar macrophages (AM) of patients with sarcoidosis in vitro. We could demonstrate that POF (above 4.10(-4) M) inhibited the secretion of superoxide anion and TNF-alpha by AM in a dose-dependent manner via a prostaglandin synthesis-dependent mechanism that was independent of the glucocorticoid receptor. POF is an interesting immunomodulating substance that should be further evaluated in clinical trials.
Körber
M
M
Klinik für Innere Medizin, Medizinischen Universität zu Lübeck.
Kamp
S
S
Kothe
H
H
Braun
J
J
Dalhoff
K
K
D000328:Adult; D005260:Female; D006801:Humans; D066298:In Vitro Techniques; D016676:Macrophages, Alveolar / Q000187:drug effects*; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D016897:Respiratory Burst / Q000187:drug effects; D012507:Sarcoidosis / Q000503:physiopathology*; D012636:Secretory Rate / Q000187:drug effects; D012969:Sodium Fluoride / Q000494:pharmacology; D013481:Superoxides / Q000378:metabolism*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D014409:Tumor Necrosis Factor-alpha; D013481:Superoxides; D012969:Sodium Fluoride; D010431:Pentoxifylline