Mouse Elk oncogene maps to chromosome X and a novel Elk oncogene (Elk3) maps to chromosome 10.
The Elk protein is a member of the Ets family found in both vertebrates and invertebrates. Human ELK1 encoded by ELK1 binds alone or together with serum response factor to DNA and regulates gene expression in a variety of biological processes. Using a panel of interspecific backcross mice, we have mapped the Elk oncogene (Elk) and a novel type Elk oncogene (Elk3), closely related to ELK1. Elk maps to Chr X, and Elk3 maps to the proximal region of Chr 10.
Tamai
Y
Y
Banyu Tsukuba Research Institute (Merck), Japan.
Taketo
M
M
Nozaki
M
M
Seldin
M F
MF
D000818:Animals; D005075:Biological Evolution; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D004268:DNA-Binding Proteins; D051379:Mice / Q000235:genetics*; D008809:Mice, Inbred C3H; D009115:Muridae / Q000235:genetics; D015513:Oncogene Proteins; D009857:Oncogenes; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors / Q000235:genetics*; D014960:X Chromosome; D050807:ets-Domain Protein Elk-1
D004268:DNA-Binding Proteins; C494113:Elk1 protein, mouse; C086924:Elk3 protein, mouse; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D050783:Proto-Oncogene Proteins c-ets; D014157:Transcription Factors; D050807:ets-Domain Protein Elk-1