title: Identification of neuronal programmed cell death in situ in the striatum of normal adult rat brain and its relationship to neuronal death during aging.
abstract: Apoptotic neurons have been identified in normal adult rat striatum by terminal deoxynucleotidyl transferase mediated dUTP-biotin nick end labeling technique. This observation suggests that neuronal programmed cell death starts at an early stage of adult life and may contribute to the aging associated neuronal loss. In addition, the frequency of apoptotic cells was found to significantly increase in old rats, which implies that aging itself accelerates the process.
authors.affiliation: Molecular Physiology and Genetics Section, NIA, Francis Scott Key Medical Center, NIH, Baltimore, MD 21224, USA.
authors.forename: L
authors.initials: L
authors.lastname: Zhang
authors.forename: G
authors.initials: G
authors.lastname: Kokkonen
authors.forename: G S
authors.initials: GS
authors.lastname: Roth
mesh_terms: D000375:Aging / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D017209:Apoptosis / Q000502:physiology*; D001710:Biotin; D006651:Histocytochemistry; D008297:Male; D017072:Neostriatum / Q000166:cytology* / Q000254:growth & development / Q000378:metabolism; D009474:Neurons / Q000378:metabolism / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D014544:Uridine Triphosphate
chemical_list: D017448:Receptors, Dopamine D2; D001710:Biotin; D014544:Uridine Triphosphate