title: Mutagenic activity of dopamine after nitrosation.
abstract: Dopamine hydrochloride is reported to be a new mutagen precursor in this study. After treatment with nitrite under acidic conditions, dopamine hydrochloride showed direct-acting mutagenicity on Salmonella typhimurium TA100, TA98 and Escherichia coli WP2uvra. The addition of S9 mix did not affect the mutagenicity of nitrosated dopamine significantly in these three strains. Meanwhile, a comparison of the mutagenicity of nitrosated dopamine with nitrosated tyramine was carried out.
authors.affiliation: Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, People's Republic of China.
authors.forename: C
authors.initials: C
authors.lastname: Su
authors.forename: B
authors.initials: B
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: Z
authors.initials: Z
authors.lastname: Liu
mesh_terms: D004298:Dopamine / Q000737:chemistry / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry*; D009573:Nitrites / Q000737:chemistry / Q000633:toxicity*; D015538:Nitrosation; D012486:Salmonella typhimurium / Q000187:drug effects; D014439:Tyramine / Q000633:toxicity
chemical_list: D009153:Mutagens; D009573:Nitrites; D004298:Dopamine; D014439:Tyramine