TGF-beta accelerated the osteogenic differentiation of bone marrow cells induced by collagen matrix.
Bone marrow cells have multipotency for differentiation. Recently we found that type I collagen matrix induced the osteogenic differentiation of bone marrow cells. In this study we showed that TGF-beta enhanced the effect of collagen matrix on bone marrow cells and accelerated the osteogenic differentiation. These results imply that TGF-beta might play a crucial role in the osteogenic differentiation of bone marrow cells during embryogenesis and the repair of bone.
Mizuno
M
M
Department of Biochemistry, School of Dentistry, Hokkaido University, Sapporo, Japan.
Kuboki
Y
Y
D000469:Alkaline Phosphatase / Q000032:analysis; D001853:Bone Marrow / Q000187:drug effects* / Q000254:growth & development; D001854:Bone Marrow Cells; D002113:Calcification, Physiologic / Q000187:drug effects; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D003094:Collagen / Q000494:pharmacology*; D004347:Drug Interactions; D008858:Microscopy, Phase-Contrast; D015675:Osteocalcin / Q000032:analysis; D010012:Osteogenesis / Q000187:drug effects*; D011863:Radioimmunoassay; D013997:Time Factors; D016212:Transforming Growth Factor beta / Q000494:pharmacology*
D016212:Transforming Growth Factor beta; D015675:Osteocalcin; D003094:Collagen; D000469:Alkaline Phosphatase