title: Peripheral blood lymphocyte subsets after allogeneic bone marrow transplantation: reconstitution and correlation with the occurrence of acute graft-versus-host disease.
abstract: Peripheral blood lymphocyte subsets were enumerated at regular intervals during the first year after allogeneic bone marrow transplantation (BMT) in 21 Chinese patients. Eight of these patients had acute graft-versus-host disease (GVHD) while they were assessed at the time of engraftment. Our results show in patients receiving allogeneic BMT: (1) T and NK cells were the predominant lymphocyte subsets in the early reconstitution stage while B cells were severely depleted; (2) absolute numbers of the major lymphocyte subsets normalised in 4-5 months; (3) an increased percentage of T cells that expressed the activation antigen HLA-DR and a reversed CD4:CD8 ratio were observed throughout the first 12 months after BMT; (4) patients with acute GVHD had significantly higher white cell count and NK cell percentage than those not complicated by acute GVHD.
authors.affiliation: Department of Pathology, University of Hong Kong, Queen Mary Hospital.
authors.forename: E Y
authors.initials: EY
authors.lastname: Chan
authors.forename: E K
authors.initials: EK
authors.lastname: Chiu
authors.forename: M K
authors.initials: MK
authors.lastname: So
authors.forename: A K
authors.initials: AK
authors.lastname: Lie
authors.forename: T K
authors.initials: TK
authors.lastname: Chan
mesh_terms: D000208:Acute Disease; D000741:Anemia, Aplastic / Q000276:immunology / Q000628:therapy; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D016516:CD4-CD8 Ratio; D005434:Flow Cytometry; D006086:Graft vs Host Disease / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000276:immunology / Q000628:therapy; D018655:Lymphocyte Count; D009101:Multiple Myeloma / Q000276:immunology / Q000628:therapy; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014184:Transplantation, Homologous
chemical_list: D006684:HLA-DR Antigens