title: Ratjadon: a new antifungal compound from Sorangium cellulosum (myxobacteria) production, physio-chemical and biological properties.
abstract: An antifungal activity, ratjadon, was detected in the culture broth of Sorangium cellulosum (Myxococcales) strain So ce360. The metabolite was quantitatively bound to the adsorber resin XAD-16, which was added to the medium at the beginning of the fermentation. The antibiotic spectrum was narrow, but some important phytopathogenic fungi, especially species of Oomycetes, were inhibited at very low concentrations.
authors.affiliation: GBF, Gesellschaft für Biotechnologische Forschung Abteilung Naturstoffbiologie, Braunschweig, Federal Republic of Germany.
authors.forename: K
authors.initials: K
authors.lastname: Gerth
authors.forename: D
authors.initials: D
authors.lastname: Schummer
authors.forename: G
authors.initials: G
authors.lastname: Höfle
authors.forename: H
authors.initials: H
authors.lastname: Irschik
authors.forename: H
authors.initials: H
authors.lastname: Reichenbach
mesh_terms: D000818:Animals; D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D051379:Mice; D008826:Microbial Sensitivity Tests; D009231:Myxococcales / Q000378:metabolism; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D011714:Pyrans