Serum thyrotropin-binding inhibiting immunoglobulin and thyroperoxidase antibody in Graves' hyperthyroidism after 131I therapy.
Seventeen patients who received radioiodine (131I) therapy for Graves' hyperthyroidism had serial blood samples taken before therapy and after therapy for a period of at least 1 year. At 1 year post-therapy, six patients were hypothyroid. Seven patients were euthyroid, and four patients were hyperthyroid. Prior to isotope administration, 14 patients had detectable serum thyrotropin-binding inhibiting immunoglobulin (TBII) and 16 patients had detectable serum thyroperoxidase antibody (TPOAb). Three to 6 months after therapy, 11 of 14 TBII-positive patients demonstrated a marked increase (> 10%) in serum TBII activity. Four patients out of 11 developed hypothyroidism and six of the 11 developed euthyroidism. A decrease in TBII was observed in three patients who developed hyperthyroidism. In the three patients with undetectable TBII prior to therapy, two had high titers of TPOAb. Seven patients demonstrated a marked increase in TPOAb 3 to 6 months after therapy. Of these, four developed hypothyroidism and three developed euthyroidism, whereas three of the four patients who had a marked decrease in TPOAb developed hyperthyroidism. This study demonstrated that an increase in serum TBII and TPOAb activity 3 to 6 months after 131I therapy, may be useful in predicting which patients may develop euthyroidism or hypothyroidism after 1 year of 131I therapy.
Hsu
C H
CH
Department of Nuclear Medicine and Clinical Pathology, Taipei Municipal Jen-Ai Hospital, Taiwan, R.O.C.
Lee
L S
LS
Chang
J J
JJ
Liao
S T
ST
Chen
S M
SM
Hwang
J Y
JY
Lo
N I
NI
D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006111:Graves Disease / Q000276:immunology* / Q000532:radiotherapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007453:Iodide Peroxidase / Q000276:immunology*; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011989:Receptors, Thyrotropin / Q000276:immunology*
D001323:Autoantibodies; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D011989:Receptors, Thyrotropin; C056626:thyroid microsomal antibodies; D007453:Iodide Peroxidase