The ripostatins, novel inhibitors of eubacterial RNA polymerase isolated from myxobacteria.
A new antibiotic, ripostatin, was isolated from the culture supernatant of the myxobacterium, sorangium cellulosum strain So ce377. It is a macrocyclic lactone carbonic acid containing an unsubstituted phenyl ring in a side chain. The antibiotic acts especially on Staphylococcus aureus, but seems not to penetrate most bacteria. The MIC values are in the range of 1 microgram/ml. Ripostatin is an inhibitor of eubacterial RNA polymerase. It interferes with the initiation of RNA synthesis.
Irschik
H
H
GBF, Gesellschaft für Biotechnologische Forschung, Department of Biology of Natural Products, Braunschweig, Germany.
Augustiniak
H
H
Gerth
K
K
Höfle
G
G
Reichenbach
H
H
D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D012321:DNA-Directed RNA Polymerases / Q000037:antagonists & inhibitors*; D006094:Gram-Positive Bacteria / Q000187:drug effects; D007783:Lactones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009231:Myxococcales / Q000737:chemistry; D012329:RNA, Bacterial; D013211:Staphylococcus aureus / Q000187:drug effects
D000900:Anti-Bacterial Agents; D007783:Lactones; D012329:RNA, Bacterial; C096600:ripostatin A; C096601:ripostatin B; D012321:DNA-Directed RNA Polymerases