Mapping of gene loci in the Q13-Q15 region of chromosome 12.
The gene loci CDK4, GLI, CHOP and MDM2 have been mapped to the q13-q15 region of chromosome 12. Using fluorescence in situ hybridization onto simultaneously DAPI-banded metaphase chromosomes and interphase nuclei, we have more precisely mapped and ordered these loci, together with a number of Genethon microsatellite markers. GLI and CHOP localize to 12q13.3-14.1, CDK4 to 12q14 and MDM2 to 12q14.3-q15, and the gene order is cen-GLI/CHOP-CDK4-MDM2. The Genethon microsatellites D12S80 and D12S83 flank MDM2.
Mitchell
E L
EL
Cancer Research Campaign Department of Cancer Genetics, Paterson Institute for Cancer Research, Christie Hospital NHS Trust, Manchester.
White
G R
GR
Santibanez-Koref
M F
MF
Varley
J M
JM
Heighway
J
J
D022762:CCAAT-Enhancer-Binding Proteins; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases; D004268:DNA-Binding Proteins / Q000235:genetics*; D005819:Genetic Markers / Q000235:genetics; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D009687:Nuclear Proteins; D015513:Oncogene Proteins / Q000235:genetics*; D017346:Protein Serine-Threonine Kinases / Q000235:genetics*; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D051736:Proto-Oncogene Proteins c-mdm2; D015534:Trans-Activators; D051742:Transcription Factor CHOP; D014157:Transcription Factors / Q000235:genetics*; D000071676:Zinc Finger Protein GLI1
D022762:CCAAT-Enhancer-Binding Proteins; C497249:DDIT3 protein, human; D004268:DNA-Binding Proteins; D005819:Genetic Markers; D009687:Nuclear Proteins; D015513:Oncogene Proteins; D011518:Proto-Oncogene Proteins; D015534:Trans-Activators; D014157:Transcription Factors; D000071676:Zinc Finger Protein GLI1; D051742:Transcription Factor CHOP; C497206:MDM2 protein, human; D051736:Proto-Oncogene Proteins c-mdm2; D017346:Protein Serine-Threonine Kinases; C495900:CDK4 protein, human; D051358:Cyclin-Dependent Kinase 4; D018844:Cyclin-Dependent Kinases