title: Malignant transformation in a fatal case of giant cell tumour of the sacrum.
abstract: Most giant cell tumours can be treated by local surgery and only rarely are they life threatening. We report a case of a giant cell tumour of the sacrum causing irresectable and fatal small bowel obstruction following malignant transformation of the tumour. The role of radiotherapy in this transformation is discussed.
authors.affiliation: Royal Surrey County Hospital, Guildford, UK.
authors.forename: J P
authors.initials: JP
authors.lastname: Crew
authors.forename: M
authors.initials: M
authors.lastname: Flannery
authors.forename: B
authors.initials: B
authors.lastname: Manners
authors.forename: C J
authors.initials: CJ
authors.lastname: Coates
mesh_terms: D000293:Adolescent; D002471:Cell Transformation, Neoplastic; D017809:Fatal Outcome; D005260:Female; D005354:Fibrosarcoma / Q000473:pathology; D018212:Giant Cell Tumor of Bone / Q000473:pathology*; D006801:Humans; D007414:Intestinal Neoplasms / Q000473:pathology; D007415:Intestinal Obstruction / Q000209:etiology; D007421:Intestine, Small; D008643:Mesentery; D010534:Peritoneal Neoplasms / Q000473:pathology; D012447:Sacrum; D013125:Spinal Neoplasms / Q000473:pathology*