Fertility after bone marrow transplantation following conditioning with cyclophosphamide and total body irradiation.
We report here two male patients who regained fertility after BMT following conditioning with cyclophosphamide and total body irradiation (TBI). Both patients received single fraction TBI. Recovery of fertility led to a pregnancy in both cases. These and three other previously reported cases are discussed.
Jacob
A
A
Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK.
Goodman
A
A
Holmes
J
J
D000208:Acute Disease; D000328:Adult; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000009:adverse effects*; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000628:therapy*; D008297:Male; D014916:Whole-Body Irradiation / Q000009:adverse effects*
D003520:Cyclophosphamide