Virucidal effects of the steam distillate from Houttuynia cordata and its components on HSV-1, influenza virus, and HIV.
The steam distillate prepared from fresh plants of Houttuynia cordata Thunb. (Saururaceae) was found to have direct inhibitory activity against herpes simplex virus type 1 (HSV-1), influenza virus, and human immunodeficiency virus type 1 (HIV-1) without showing cytotoxicity, but not against poliovirus and coxsackie-virus. The loss of viral infectivity was related to the duration of drug treatment. Three major components of the distillate, methyl n-nonyl ketone, lauryl aldehyde, and capryl aldehyde, also inactivated HSV-1, influenza virus, and HIV-1. These in vitro findings demonstrate that the essential oils provide virucidal activity against enveloped viruses by interfering with the function of virus envelope.
Hayashi
K
K
Department of Virology, Toyama Medical and Pharmaceutical University, Japan.
Kamiya
M
M
Hayashi
T
T
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002460:Cell Line; D002470:Cell Survival / Q000187:drug effects; D004285:Dogs; D015497:HIV-1 / Q000187:drug effects* / Q000502:physiology; D006367:HeLa Cells; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D009980:Influenza A virus / Q000187:drug effects* / Q000502:physiology; D007564:Japan; D007668:Kidney; D008518:Medicine, East Asian Traditional; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D010936:Plant Extracts