title: Integrin expression in head and neck cancers.
abstract: Neoplastic transformation results in rearrangement of the cell membrane with a breakdown of the regular expression of adhesion molecules such as integrins. A relationship may exist between the intensity of this alteration, and the form it takes, and a tumour's ability to metastatise. We studied this possibility by investigating the epithelial integrin expression of 35 head and neck squamous cell carcinomas. Two types of positivity were observed: one associated with tumours with a better prognostic index, the other with those characterized by greater malignancy.
authors.affiliation: II ENT Department, University of Torino, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Cortesina
authors.forename: M
authors.initials: M
authors.lastname: Sacchi
authors.forename: M
authors.initials: M
authors.lastname: Bussi
authors.forename: B
authors.initials: B
authors.lastname: Panizzut
authors.forename: S
authors.initials: S
authors.lastname: Ferro
authors.forename: M T
authors.initials: MT
authors.lastname: Carlevato
authors.forename: P C
authors.initials: PC
authors.lastname: Marchisio
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D015815:Cell Adhesion Molecules / Q000032:analysis; D046508:Culture Techniques; D004848:Epithelium / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D016023:Integrins / Q000032:analysis*; D007797:Laminin / Q000032:analysis; D007822:Laryngeal Neoplasms / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D007830:Larynx / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D009960:Oropharynx / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D011379:Prognosis; D017474:Receptors, Laminin; D000097794:Kalinin
chemical_list: D015815:Cell Adhesion Molecules; D016023:Integrins; D007797:Laminin; D017474:Receptors, Laminin; D000097794:Kalinin