NMDA-induced rhythmical activity in XII nerve of isolated CNS from newborn rats.
We tried to induce rhythmical oro-facial motor activities in an isolated brain stem-spinal cord preparation from newborn rats. Neural activities were monitored from the hypoglossal nerve (XII N) and the ventral roots of the cervical cord. Bath application of N-methyl-D-aspartate (NMDA) as well as glutamate induced rhythmical burst activity in XII N distinct from and much faster than respiratory rhythm. This NMDA-induced rhythmical activity was blocked by simultaneous application of 2-amino-5-phosphonovalerate (AP5). The results demonstrate that NMDA receptor activation can induce rhythmical XII N activity different from respiration in an isolated mammalian CNS. This preparation will be useful for the investigation of neural mechanisms underlying the central generation of food ingestive movements.
Katakura
N
N
Department of Physiology, Faculty of Dentistry, Tokyo Medical and Dental University, Japan.
Jia
L
L
Nakamura
Y
Y
D000818:Animals; D000831:Animals, Newborn; D001933:Brain Stem / Q000187:drug effects*; D007002:Hypoglossal Nerve / Q000187:drug effects*; D066298:In Vitro Techniques; D009068:Movement / Q000187:drug effects*; D016202:N-Methylaspartate / Q000494:pharmacology*; D010507:Periodicity; D051381:Rats; D017208:Rats, Wistar; D013116:Spinal Cord / Q000187:drug effects*
D016202:N-Methylaspartate