[A comparative study of DNA measurement of bladder cancer from image cytometry and chromosome aberration in in situ hybridization].
The relationship between interphase cytogenetics and the DNA index measuring SCM of bladder cancer was investigated in 17 patients with bladder tumor. By in situ hybridization, the copy number of chromosomes 1, 7, 10, 11, 17, 18, X and Y was detected. The percentage of hyperdiploid cells for chromosomes 7 and 17 was highly correlated with the increasing DNA index. Since a high DNA index is both indicative of more aggressive tumor behavior and a worse prognosis, these findings suggest that the percentage of hyperdiploid cells, especially for chromosome 7 and 17, may be highly predictive of bladder tumor aggressiveness.
Nemoto
R
R
Dept. of Urology, Tottori Prefectural Central Hospital.
Nakamura
I
I
Uchida
K
K
Harada
M
M
D002295:Carcinoma, Transitional Cell / Q000235:genetics*; D002869:Chromosome Aberrations; D003592:Cytophotometry / Q000379:methods; D015342:DNA Probes; D004273:DNA, Neoplasm / Q000032:analysis*; D018628:Gene Dosage; D006801:Humans; D017403:In Situ Hybridization; D001749:Urinary Bladder Neoplasms / Q000235:genetics*
D015342:DNA Probes; D004273:DNA, Neoplasm