title: Palmar filiform hyperkeratosis: a new paraneoplastic syndrome?
abstract: Filiform hyperkeratosis of the palms and soles is a rare disorder. We describe a 70-year-old man with a 2-year history of multiple, filiform, keratotic projections on the palms and a nodular malignant melanoma on the back. Histopathologic examination of the palmar lesions revealed that each single keratotic projection was composed of a well-defined, compact parakeratotic column. The underlying epidermis showed a thinned granular layer. Five other cases of palmoplantar filiform hyperkeratosis in association with malignant neoplasms have been reported. Filiform hyperkeratosis of the palms and soles may represent a distinct paraneoplastic condition.
authors.affiliation: Department of Dermatology, University of Graz, Austria.
authors.forename: S
authors.initials: S
authors.lastname: Kaddu
authors.forename: H P
authors.initials: HP
authors.lastname: Soyer
authors.forename: H
authors.initials: H
authors.lastname: Kerl
mesh_terms: D000368:Aged; D005528:Foot; D006225:Hand; D006801:Humans; D007642:Keratosis / Q000145:classification / Q000473:pathology*; D008297:Male; D010257:Paraneoplastic Syndromes / Q000473:pathology*