title: Immunohistochemical demonstration of taurine in the rat cerebellar cortex. Evidence for its location within mossy fibers and Golgi axons.
abstract: Taurine, 2-aminoethanesulfonic acid, is one of the most abundant amino acid present in the Central Nervous System. Nevertheless, its functions are remain uncertain. Taking as a basis the immunocytochemical pre-embedding PAP-techniques for demonstrating Taurine-Like substances on cerebellar cortex of rats we have observed positive immunoreaction within Purkinje cell bodies and their dendrites. Likewise, taurine has been demonstrated within mossy fibers and Golgi axons, as well as in glial processes. Our results demonstrate the wide distribution of Taurine in the cerebellar cortex, justifying its possible involvement as an inhibitory neurotransmitter, neuromodulator or as a gliotransmitter.
authors.affiliation: Department of Cellular Biology, Faculty of Biological Sciences, Complutense University of Madrid, Spain.
authors.forename: R R
authors.initials: RR
authors.lastname: Gragera
authors.forename: E
authors.initials: E
authors.lastname: Muñiz
authors.forename: G
authors.initials: G
authors.lastname: De Esteban
authors.forename: M J
authors.initials: MJ
authors.lastname: Alonso
authors.forename: R
authors.initials: R
authors.lastname: Martínez-Rodríguez
mesh_terms: D000818:Animals; D001369:Axons / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D002540:Cerebral Cortex / Q000378:metabolism*; D007150:Immunohistochemistry; D008297:Male; D008928:Mitochondria / Q000648:ultrastructure; D009412:Nerve Fibers / Q000276:immunology / Q000378:metabolism / Q000648:ultrastructure; D009457:Neuroglia / Q000276:immunology; D017729:Presynaptic Terminals / Q000276:immunology; D011689:Purkinje Cells / Q000276:immunology / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013654:Taurine / Q000276:immunology / Q000378:metabolism*
chemical_list: D013654:Taurine