title: The rat-pull test procedure: a method for assessing the strength of rats.
abstract: A novel method for the measurement of rat strength is described. The method makes use of a rat's natural inclination to move forcibly and rapidly toward an enclosed, darkened compartment. Acrylamide (200.0 mg/kg, IP), gentamicin (30.0 mg/kg, IP), d-tubocurarine (0.1 mg/kg, IP), and diazepam (3.0, 10.0, and 30.0 mg/kg, PO) significantly decreased strength. The rat-pull test procedure provides a sensitive, reliable, and valid method for the measurement of strength in rats.
authors.affiliation: Abbott Laboratories, Abbott Park, IL 60064-3500, USA.
authors.forename: W J
authors.initials: WJ
authors.lastname: Giardina
authors.forename: C T
authors.initials: CT
authors.lastname: Wismer
mesh_terms: D020106:Acrylamide; D000178:Acrylamides / Q000494:pharmacology; D000818:Animals; D003975:Diazepam / Q000494:pharmacology; D016552:Ergometry / Q000379:methods / Q000662:veterinary*; D005069:Evaluation Studies as Topic; D005839:Gentamicins / Q000494:pharmacology; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014403:Tubocurarine / Q000494:pharmacology
chemical_list: D000178:Acrylamides; D005839:Gentamicins; D020106:Acrylamide; D003975:Diazepam; D014403:Tubocurarine