Effects of ibogaine on sensory-motor function, activity, and spatial learning in rats.
Ibogaine, a naturally occurring alkaloid, has been show to reduce naloxone-precipitated withdrawal symptoms from morphine. Given the clinical possibilities, it is important to determine ibogaine's effects on sensory-motor function, activity, learning, and memory. Long-Evans rats injected with doses of 20-60 mg/kg of ibogaine displayed slower response times on sensory and sensory-motor tests and were impaired in performing specific motor reflexes at doses of 40-60 mg/kg. Furthermore, these rats showed a marked reduction in locomotor and nonlocomotor activity, as well as emotionality at doses ranging from 10-40 mg/kg. At the higher doses the rats appeared to be virtually inactive. There were also deficits in learning a spatial location task (a dry-land version of the Morris water-maze). The deficits, however, were probably due to a reduction in locomotor activity and reduction in detection of sensory information. In a final experiment, a single injection of 40 mg/kg of ibogaine had marked deleterious effects on the acquisition of the spatial location task 1 but not 7 days after the injection, even though in this case there were no effects on sensory motor function 1 or 7 days after the injection. Thus, there are severe sensory-motor activity and learning problems while the animal is under the influence of ibogaine (acute effect) as well as long-term consequences on learning without concomitant changes in sensory-motor function.
Kesner
R P
RP
Department of Psychology, University of Utah, Salt Lake City 84112, USA.
Jackson-Smith
P
P
Henry
C
C
Amann
K
K
D000818:Animals; D004305:Dose-Response Relationship, Drug; D004644:Emotions / Q000187:drug effects; D007050:Ibogaine / Q000494:pharmacology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects; D009043:Motor Activity / Q000187:drug effects*; D009949:Orientation / Q000187:drug effects; D010775:Photic Stimulation; D004856:Postural Balance / Q000187:drug effects; D051381:Rats; D012018:Reflex / Q000187:drug effects; D013028:Space Perception / Q000187:drug effects*
D007050:Ibogaine