Leukocyte adhesion and the anti-inflammatory effects of leukocyte integrin blockade.
The past several years have produced a dramatic increase in our understanding of the steps involved in the infiltration of leukocytes into inflamed tissues. At least four major families of adhesion molecules: the selectins, sialomucins, integrins, and Ig supergene family CAMs have been identified; and their interactions are being elucidated. The role of the leukocyte beta 2 and alpha 4 integrins and the selective use of these integrins by leukocytes for migration into inflamed tissues in various organs is presented.
Issekutz
T B
TB
Department of Pediatrics, Dalhousie University, Halifax, Canada.
D000818:Animals; D015815:Cell Adhesion Molecules / Q000502:physiology; D002465:Cell Movement / Q000502:physiology; D006801:Humans; D007249:Inflammation / Q000503:physiopathology*; D016023:Integrins / Q000037:antagonists & inhibitors* / Q000378:metabolism; D007961:Leukocyte Migration-Inhibitory Factors / Q000502:physiology*; D007962:Leukocytes / Q000378:metabolism*; D009077:Mucins / Q000502:physiology; D052116:Sialomucins
D015815:Cell Adhesion Molecules; D016023:Integrins; D007961:Leukocyte Migration-Inhibitory Factors; D009077:Mucins; D052116:Sialomucins