title: Accumulation of wild-type p53 in meningiomas.
abstract: The p53 tumour suppressor gene contributes to the regulation of DNA repair and the initiation of apoptosis. Mutations of this gene and nuclear accumulation of its protein product are features of a large variety of tumours. A histological spectrum of meningiomas, including anaplastic examples and a meningosarcoma, was analysed for accumulation of the p53 protein and mutations in exons 4-9 of the p53 gene. No mutations were found, but 9/34 (26%) tumours showed accumulation of the p53 protein. The p53-positive meningiomas came from across the histological spectrum and were not restricted to the anaplastic group. The accumulation of wild-type p53 in a proportion of meningiomas may reflect this gene's role in DNA repair, or its enhanced stability when bound to cellular proteins such as the mdm-2 gene product.
authors.affiliation: Department of Neuropathology, Southampton General Hospital, UK.
authors.forename: D W
authors.initials: DW
authors.lastname: Ellison
authors.forename: J
authors.initials: J
authors.lastname: Lunec
authors.forename: P J
authors.initials: PJ
authors.lastname: Gallagher
authors.forename: P V
authors.initials: PV
authors.lastname: Steart
authors.forename: E
authors.initials: E
authors.lastname: Jaros
authors.forename: K C
authors.initials: KC
authors.lastname: Gatter
mesh_terms: D000911:Antibodies, Monoclonal; D001483:Base Sequence; D002467:Cell Nucleus / Q000378:metabolism; D004260:DNA Repair; D004273:DNA, Neoplasm / Q000096:biosynthesis; D005091:Exons / Q000235:genetics; D015972:Gene Expression Regulation, Neoplastic / Q000502:physiology*; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D007150:Immunohistochemistry; D008577:Meningeal Neoplasms / Q000235:genetics* / Q000378:metabolism; D008579:Meningioma / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D009154:Mutation; D016133:Polymerase Chain Reaction
chemical_list: D000911:Antibodies, Monoclonal; D004273:DNA, Neoplasm