Preoperative factors of prognostic significance in gastric cancer.
This study was undertaken to investigate the ability of local anatomical and primary histological features of gastric cancers, as well as DNA analysis, to predict prognosis. Using multivariate analysis, results indicate that location of a tumor in the gastric cardia, poor differentiation, involvement of adjacent organs, and aneuploidy are all independent predictors of survival. All of the factors studied can be determined by endoscopic procedures preoperatively on patients with gastric cancers and could be helpful in selecting some patients for perioperative adjunctive therapies.
Johnson
H
H
Department of Surgery, Long Island Jewish Medical Center, New Hyde Park, New York, USA.
Belluco
C
C
Masood
S
S
Azama
A
A
Kahn
L
L
Wise
L
L
D000230:Adenocarcinoma / Q000235:genetics / Q000401:mortality* / Q000473:pathology* / Q000601:surgery; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004247:DNA / Q000235:genetics; D005260:Female; D006801:Humans; D015993:Life Tables; D008297:Male; D008875:Middle Aged; D011003:Ploidies; D011379:Prognosis; D013274:Stomach Neoplasms / Q000235:genetics / Q000401:mortality* / Q000473:pathology* / Q000601:surgery
D004247:DNA