Influence of route of administration on progesterone metabolism.
While inducing similar progesterone levels, the ratio of 5 alpha- and 5 beta-pregnanolone/progesterone plasma concentrations has been dramatically increased after oral as opposed to vaginal administration, in a cross-over study. The known psychotropic effects of 5 alpha- and 5 beta-pregnanolone lead to different indications and precautions for oral and vaginal administration of progesterone.
de Lignieres
B
B
Département d'endocrinologie et Médecine de la Reproduction, Hopital Necker, Paris, France.
Dennerstein
L
L
Backstrom
T
T
D004092:20-alpha-Dihydroprogesterone / Q000097:blood; D000282:Administration, Intravaginal; D000284:Administration, Oral; D018592:Cross-Over Studies; D003900:Desoxycorticosterone / Q000097:blood; D005260:Female; D006801:Humans; D011280:Pregnanolone / Q000097:blood; D011374:Progesterone / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
D004092:20-alpha-Dihydroprogesterone; D003900:Desoxycorticosterone; D011374:Progesterone; D011280:Pregnanolone