title: Antibody to ICAM-1 mediates enhancement of HIV-1 infection of human endothelial cells.
abstract: Human umbilical vein endothelial cells (HUVEC) can be abortively infected with HIV-1, but virus production is rescued by the addition of T cells. Monoclonal antibody (Mab) to ICAM-1, but not its Fab' fragment or MAbs to LFA-1 and PECAM-1, increases HIV-1 infection of HUVEC by enhancing HIV-1 absorption. Enhancement by anti ICAM-1 is probably due to a bridging effect different from the ADE mediated by anti-gp120 that involves FcR or CR-mediated capture of the virus-antibody complex. Since antibodies to cell membrane molecules are present in HIV-1 infected patients, the ADE mediated by such a mechanism can be important in AIDS pathogenesis.
authors.affiliation: Gamaleya Institute for Microbiology and Epidemiology, Moscow, Russia.
authors.forename: O
authors.initials: O
authors.lastname: Scheglovitova
authors.forename: V
authors.initials: V
authors.lastname: Scanio
authors.forename: S
authors.initials: S
authors.lastname: Fais
authors.forename: S
authors.initials: S
authors.lastname: Papadia
authors.forename: I
authors.initials: I
authors.lastname: Abbate
authors.forename: C
authors.initials: C
authors.lastname: Castilletti
authors.forename: F
authors.initials: F
authors.lastname: Dianzani
authors.forename: M R
authors.initials: MR
authors.lastname: Capobianchi
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000821:virology*; D015497:HIV-1 / Q000502:physiology*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000502:physiology*; D007371:Interferon-gamma / Q000494:pharmacology
chemical_list: D000911:Antibodies, Monoclonal; D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma