Two brothers with bilateral optic neuropathy.
A young man developed bilateral, consecutive, optic neuropathy. His brother had had a similar problem and recovered after one year. Mitochondrial DNA analysis showed that both had the 14484 mutation associated with Leber's hereditary optic neuropathy.
Hedges
T R
TR
Department of Ophthalmology, Tufts University School of Medicine, New England Eye Center, Boston, Massachusetts, USA.
Sedwick
L A
LA
Newman
N J
NJ
D000293:Adolescent; D004247:DNA / Q000032:analysis; D004272:DNA, Mitochondrial / Q000235:genetics; D003937:Diagnosis, Differential; D005654:Fundus Oculi; D006801:Humans; D008297:Male; D015418:Optic Atrophies, Hereditary / Q000175:diagnosis* / Q000235:genetics / Q000503:physiopathology; D017354:Point Mutation; D014786:Vision Disorders / Q000175:diagnosis / Q000235:genetics / Q000503:physiopathology; D014785:Vision, Ocular / Q000502:physiology; D014792:Visual Acuity; D014794:Visual Fields
D004272:DNA, Mitochondrial; D004247:DNA