Cyclin A links c-Myc to adhesion-independent cell proliferation.
Adhesion-independent growth is a neoplastic phenotype that is inducible in Rat 1a fibroblasts by enforced MYC expression. The c-Myc protein has been well characterized as a transcription factor, yet the molecular basis of c-Myc-induced neoplastic transformation has remained elusive. In this report, we demonstrate a link between ectopic MYC expression, deregulated cyclin A levels, and adhesion-independent growth.
Barrett
J F
JF
Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA.
Lewis
B C
BC
Hoang
A T
AT
Alvarez
R J
RJ
Dang
C V
CV
D000818:Animals; D002448:Cell Adhesion / Q000502:physiology*; D002471:Cell Transformation, Neoplastic; D002478:Cells, Cultured; D016213:Cyclins / Q000235:genetics / Q000378:metabolism*; D005347:Fibroblasts; D005786:Gene Expression Regulation; D006801:Humans; D016271:Proto-Oncogene Proteins c-myc / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D011994:Recombinant Proteins / Q000378:metabolism
D016213:Cyclins; D016271:Proto-Oncogene Proteins c-myc; D011994:Recombinant Proteins