Adenosine analogues modulate the incidence of sleep apneas in rats.
The effects of adenosine A1 and A2 agonists on spontaneous central sleep apneas in rats have been examined by simultaneously monitoring sleep and respiration in freely moving unanesthetized animals. Intraperitoneal administration of 1.0 mg/kg of the A1 receptor agonist R(-)N6-L-(2-phenyl-isopropyl)adenosine (L-PIA) and 150 and 300 micrograms/kg of 2-p-(2-carboxyethyl)phenethylamino-5'-N-ethylcarboxamido-adenosine hydrochloride (CGS 21680), a selective A2 agonist, decreased the apnea index (AI) during sleep. Within a sleep period, AI increased over time in both control and drug-treated animals. For both agonists, doses effective in reducing AI also significantly reduced sleep efficiency.
Monti
D
D
Department of Pharmacology, College of Medicine, University of Illinois at Chicago 60612, USA.
Carley
D W
DW
Radulovacki
M
M
D000241:Adenosine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology*; D000818:Animals; D000959:Antihypertensive Agents / Q000008:administration & dosage / Q000494:pharmacology; D002344:Carotid Body / Q000187:drug effects; D007274:Injections, Intraperitoneal; D010627:Phenethylamines / Q000008:administration & dosage / Q000494:pharmacology; D010660:Phenylisopropyladenosine / Q000008:administration & dosage / Q000494:pharmacology; D017286:Polysomnography; D058906:Purinergic P1 Receptor Agonists; D051381:Rats; D017207:Rats, Sprague-Dawley; D015656:Respiratory Mechanics / Q000187:drug effects; D012891:Sleep Apnea Syndromes / Q000188:drug therapy* / Q000523:psychology; D013268:Stimulation, Chemical
D000959:Antihypertensive Agents; D010627:Phenethylamines; D058906:Purinergic P1 Receptor Agonists; C061282:2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine; D010660:Phenylisopropyladenosine; D000241:Adenosine