Specific immune tolerance related to disparity in MHC class I region.
A specific immune tolerance in mature, immunologically competent individuals may be induced by incompatibility for some of the class I major histocompatibility complex (MHC) antigens. This is suggested by results of experimental and clinical studies of organ transplantation and of antibody production. These results indicate the existence of tolerance-promoting allogenic markers within the MHC class I region.
Bućin
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University Hospital Blood Center, Lund, Sweden.
D000483:Alleles; D000818:Animals; D001803:Blood Transfusion; D005805:Genes, MHC Class I; D006680:HLA Antigens / Q000235:genetics / Q000276:immunology; D006648:Histocompatibility; D006801:Humans; D007108:Immune Tolerance / Q000235:genetics*; D007518:Isoantibodies / Q000096:biosynthesis / Q000276:immunology; D016030:Kidney Transplantation; D016031:Liver Transplantation; D018448:Models, Immunological; D051381:Rats; D013552:Swine; D013556:Swine, Miniature / Q000276:immunology; D014181:Transplantation Immunology
D006680:HLA Antigens; D007518:Isoantibodies