Effects of topically applied spironolactone on androgen stimulated sebaceous glands in the hamster pinna.
The effects of spironolactone (5% SYC-201G, a preparation developed for clinical use in acne vulgaris by Searle Yakuhin K.K.), which is known to have antiandrogenic effects by competitively inhibiting dihydrotestosterone at androgen receptor sites, was topically applied to the androgen stimulated sebaceous glands of adult female golden hamsters. Androgen stimulation, induced by intramuscular injection of testosterone propionate (TP) every other day over a two week period, resulted in a 2.5 to 2.7 time increase in the size of the sebaceous glands of the hamster pinna. Once-daily treatment with 5% SYC-201G or matching placebo was applied to androgen-stimulated hamsters on one pinna only during the same period as TP injection. Comparison between the treated and untreated sides revealed a significant suppression in the sebaceous gland size (p < 0.05) by 5% SYC-201G; no such effect was observed with placebo. The difference in the suppression rate of the sebaceous gland size between 5% SYC-201G (23%) and matching placebo (-4.7%) was significant (p < 0.01).
Seki
T
T
Department of Dermatology, Faculty of Medicine, Toyama Medical and Pharmaceutical University, Japan.
Toyomoto
T
T
Morohashi
M
M
D000287:Administration, Topical; D000818:Animals; D006224:Cricetinae; D004195:Disease Models, Animal; D005260:Female; D008647:Mesocricetus; D012627:Sebaceous Glands / Q000187:drug effects* / Q000473:pathology; D012871:Skin Diseases / Q000139:chemically induced / Q000188:drug therapy; D013148:Spironolactone / Q000008:administration & dosage / Q000494:pharmacology*; D013739:Testosterone / Q000008:administration & dosage
D013148:Spironolactone; D013739:Testosterone