title: A HinfI polymorphism in the 5' flanking region of the human VNTR locus D1S80.
abstract: A restriction fragment length polymorphism (RFLP) characterized by the presence (HinfI+) or absence (HinfI-) of a HinfI site has been found in the 5' flanking region of the VNTR locus D1S80. RFLP-allele frequencies were determined from 82 unrelated individuals: HinfI+ = 0.49, HinfI- = 0.51. The RFLP/VNTR haplotype frequencies show an absolute association between the HinfI+ allele and the VNTR allele of 18 repeat units and an extreme association between the HinfI- allele and the VNTR allele of 24 repeat units. The remaining VNTR alleles associate more randomly with the 2 flanking HinfI alleles.
authors.affiliation: Instituto Nacional de Toxicologia, Sección de Biología, Madrid, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Alonso
authors.forename: P
authors.initials: P
authors.lastname: Martin
authors.forename: C
authors.initials: C
authors.lastname: Albarrán
authors.forename: M
authors.initials: M
authors.lastname: Sancho
mesh_terms: D000328:Adult; D000483:Alleles; D002648:Child; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D010334:Paternity; D012150:Polymorphism, Restriction Fragment Length; D013030:Spain
chemical_list: D004268:DNA-Binding Proteins; D005819:Genetic Markers