title: Methanol half-life during ethanol administration: implications for management of methanol poisoning.
abstract: OBJECTIVE
  To determine the half-life of methanol in methanol-poisoned patients who are treated with ethanol but not with hemodialysis.
  
  
  METHODS
  Case series.
  
  
  METHODS
  University Hospital, University of Manitoba.
  
  
  METHODS
  Three methanol-poisoned patients treated with ethanol but not with hemodialysis and three similar patients identified by a literature review.
  
  
  RESULTS
  Plots of terminal concentration versus time data were inconsistent with zero-order kinetics and were adequately explained by an apparent first-order process. The median half-life of methanol in these patients was 43.1 hours, with a range of 30.3 to 52.0 hours.
  
  
  CONCLUSIONS
  Because of the significantly increased risk of toxicity and complications during ethanol monotherapy, we suggest that hemodialysis be considered for methanol-poisoned patients who are treated with ethanol infusion.
authors.affiliation: Department of Emergency Medicine, University of Manitoba, Brandon, Canada.
authors.forename: W
authors.initials: W
authors.lastname: Palatnick
authors.forename: L W
authors.initials: LW
authors.lastname: Redman
authors.forename: D S
authors.initials: DS
authors.lastname: Sitar
authors.forename: M
authors.initials: M
authors.lastname: Tenenbein
mesh_terms: D000328:Adult; D000435:Alcoholic Intoxication / Q000188:drug therapy; D002675:Child, Preschool; D000431:Ethanol / Q000008:administration & dosage / Q000627:therapeutic use*; D006207:Half-Life; D006801:Humans; D008297:Male; D000432:Methanol / Q000493:pharmacokinetics* / Q000506:poisoning*; D008875:Middle Aged
chemical_list: D000431:Ethanol; D000432:Methanol