title: TFIIH: a link between transcription, DNA repair and cell cycle regulation.
abstract: TFIIH is a basal transcription factor for protein-coding genes. It contains ERCC2, ERCC3, MO15 and cyclin H, polypeptides implicated in nucleotide excision repair or cell cycle regulation. The dysfunction of TFIIH could result in a large panel of genetic disorders, such as xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy. This link between transcription, DNA repair and cell cycle has highlighted a complex and essential role for TFIIH in the cell and has provided much information on the molecular mechanisms of each of these cellular processes.
authors.affiliation: Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France.
authors.forename: T
authors.initials: T
authors.lastname: Seroz
authors.forename: J R
authors.initials: JR
authors.lastname: Hwang
authors.forename: V
authors.initials: V
authors.lastname: Moncollin
authors.forename: J M
authors.initials: JM
authors.lastname: Egly
mesh_terms: D002453:Cell Cycle; D003057:Cockayne Syndrome / Q000235:genetics; D004265:DNA Helicases / Q000378:metabolism*; D004260:DNA Repair; D006197:Hair / Q000002:abnormalities; D006801:Humans; D051758:Transcription Factor TFIIH; D014157:Transcription Factors / Q000378:metabolism*; D019473:Transcription Factors, TFII; D014158:Transcription, Genetic; D014983:Xeroderma Pigmentosum / Q000235:genetics
chemical_list: D014157:Transcription Factors; D019473:Transcription Factors, TFII; D051758:Transcription Factor TFIIH; D004265:DNA Helicases