Urinary enzyme changes in children undergoing cineangiographic evaluation using iopromid.
Nephropathy due to radiocontrast media presents with a wide spectrum of changes from reversible renal dysfunction to oliguria requiring dialysis. Nineteen patients (mean age 4.5 +/- 3.7 years) were included. Mean +/- SD values of the variables obtained before and 48 hours after angiography were the following: plasma creatinine: 0.6 +/- 0.10 and 0.6 +/- 0.16 mg/dl; endogenous creatinine clearance: 76.1 +/- 17.0 and 80.9 +/- 19.3 ml/min/1.73 m2; plasma osmolality: 279 +/- 23 and 298 +/- 39 mOsm/kg H2O; urine osmolality: 429 +/- 225 and 459 +/- 196 mOsm/kg H2O; fractional sodium excretion: 2.1 +/- 1.3% and 2.4 +/- 1.3%; plasma uric acid: 3.9 +/- 1.3 and 3.4 +/- 1.0 mg/dl; urinary AST/creatinine: 5.2 +/- 4.8 and 4.2 +/- 2.6 mU/mg; ALT/creatinine: 16.8 +/- 12.4 and 15.3 +/- 12.6 mU/mg; LDH/creatinine: 52.0 +/- 39.6 and 42.3 +/- 31.5 mU/mg; NAG/creatinine: 20.1 +/- 2.8 and 16.8 +/- 2.3 mU/mg, respectively. The changes in renal function parameters and urinary enzyme levels were insignificant statistically (p > 0.05). In conclusion, iopromid injection at maximum doses of 5 ml/kg does not result in injury to the tubular epithelium leading to increased urinary enzyme levels.
Kavukçu
S
S
Department of Paediatrics, Dokuz Eylül University, School of Medicine, Izmir, Turkey.
Tavli
V
V
Fadiloğlu
M
M
Akhunlar
H
H
Oran
B
B
Akçoral
A
A
D000118:Acetylglucosaminidase / Q000097:blood / Q000652:urine*; D000293:Adolescent; D006328:Cardiac Catheterization; D002648:Child; D002675:Child, Preschool; D002932:Cineangiography; D003287:Contrast Media / Q000009:adverse effects*; D003404:Creatinine / Q000378:metabolism; D005260:Female; D006330:Heart Defects, Congenital / Q000000981:diagnostic imaging* / Q000201:enzymology; D006801:Humans; D007223:Infant; D007472:Iohexol / Q000009:adverse effects / Q000031:analogs & derivatives*; D007770:L-Lactate Dehydrogenase / Q000097:blood / Q000652:urine*; D008297:Male; D000637:Transaminases / Q000097:blood / Q000652:urine*
D003287:Contrast Media; D007472:Iohexol; C038192:iopromide; D003404:Creatinine; D007770:L-Lactate Dehydrogenase; D000637:Transaminases; D000118:Acetylglucosaminidase