title: Toluene induces behavioral activation without affecting striatal dopamine metabolism in the rat: behavioral and microdialysis studies.
abstract: We examined the effects of toluene on the release of dopamine (DA) and its metabolites in rat striatum using microdialysis. Intraperitoneal injection of 800 mg/kg toluene significantly increased motor activity in rats, as did methamphetamine (MAP) (1 mg/kg). However, 800 mg/kg toluene did not affect the extracellular levels of DA, 3,4-dihydroxyphenylacetic acid, homovanillic acid, or 5-hydroxyindoleacetic acid. This is in contrast to MAP, which significantly increased extracellular DA and decreased the extracellular levels of its metabolites. These results suggest that toluene-induced behavioral augmentation may not be associated with alterations in DA or serotonin neurochemistry such as are associated with MAP-induced behavioral augmentation.
authors.affiliation: Department of Hygiene, Nagoya University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kondo
authors.forename: J
authors.initials: J
authors.lastname: Huang
authors.forename: G
authors.initials: G
authors.lastname: Ichihara
authors.forename: M
authors.initials: M
authors.lastname: Kamijima
authors.forename: I
authors.initials: I
authors.lastname: Saito
authors.forename: E
authors.initials: E
authors.lastname: Shibata
authors.forename: Y
authors.initials: Y
authors.lastname: Ono
authors.forename: N
authors.initials: N
authors.lastname: Hisanaga
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: D
authors.initials: D
authors.lastname: Nakahara
mesh_terms: D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D004298:Dopamine / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D008297:Male; D008694:Methamphetamine / Q000494:pharmacology; D017551:Microdialysis; D009043:Motor Activity / Q000187:drug effects; D017072:Neostriatum / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D014050:Toluene / Q000494:pharmacology*
chemical_list: D014050:Toluene; D008694:Methamphetamine; D004298:Dopamine