title: Localization of gingival overgrowth in heart transplant patients undergoing cyclosporin therapy.
abstract: This research was aimed at determining and comparing the pattern of localization of both cyclosporin-induced gingival overgrowth and associated periodontal variables in heart transplant patients. Thirty-nine patients undergoing cyclosporin treatment were studied for 6 months following transplant surgery. Oral hygiene and gingivitis were evaluated using the Silness-Löe and Löe-Silness indices. Gingival overgrowth was measured using a periodontal probe to determine the height of the gingiva at six points per tooth. Statistical hypothesis testing was applied to calculate the significance of the results. Overgrowth average showed a steady and significant growth. The graphs depicting average overgrowth localization, "standard periodontograms," showed remarkable symmetry, and a significantly anterior mandibular papillary distribution. No overgrowth was observed in edentulous areas. The localization of plaque and gingivitis followed a similar pattern; a highly significant correlation was found with the overgrowth localization pattern. It was concluded that the elimination of plaque is an important preventive measure for cyclosporin-induced gingival overgrowth, and that tooth or periodontium related factors have a significant impact on its pathogenesis.
authors.affiliation: Complutense University, Faculty of Dentistry, Department of Oral Medicine and Surgery, Madrid, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Somacarrera
authors.forename: G
authors.initials: G
authors.lastname: Hernández
authors.forename: J
authors.initials: J
authors.lastname: Acero
authors.forename: B S
authors.initials: BS
authors.lastname: Moskow
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D002648:Child; D016572:Cyclosporine / Q000009:adverse effects*; D003773:Dental Plaque / Q000150:complications / Q000473:pathology; D005260:Female; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D016027:Heart Transplantation; D006801:Humans; D008297:Male; D008875:Middle Aged; D009911:Oral Hygiene Index; D018709:Statistics, Nonparametric
chemical_list: D016572:Cyclosporine