title: Structure-activity relationships of phenyl- and benzoylpyrroles.
abstract: Antitumor, antimicrobial, and phytotoxic activities of the marine antibiotic pentabromopseudilin (1a) and related phenyl-, benzyl- and benzoyl pyrroles were compared. All activities depended strongly on the substituent pattern, with the natural compound 1a being the most active one. As judged from model reactions, a covalent bond of nucleophiles to the pyrrole system may be involved in the inhibition of macromolecular syntheses.
authors.affiliation: Institut für Organische Chemie, Universität Göttingen, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Laatsch
authors.forename: B
authors.initials: B
authors.lastname: Renneberg
authors.forename: U
authors.initials: U
authors.lastname: Hanefeld
authors.forename: M
authors.initials: M
authors.lastname: Kellner
authors.forename: H
authors.initials: H
authors.lastname: Pudleiner
authors.forename: G
authors.initials: G
authors.lastname: Hamprecht
authors.forename: H P
authors.initials: HP
authors.lastname: Kraemer
authors.forename: H
authors.initials: H
authors.lastname: Anke
mesh_terms: D000818:Animals; D000890:Anti-Infective Agents / Q000737:chemistry* / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D005260:Female; D006860:Hydrogen Bonding; D007928:Lethal Dose 50; D007939:Leukemia L1210 / Q000473:pathology; D008546:Melanoma, Experimental / Q000473:pathology; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D010944:Plants / Q000187:drug effects*; D011758:Pyrroles / Q000737:chemistry* / Q000494:pharmacology*; D013329:Structure-Activity Relationship
chemical_list: D000890:Anti-Infective Agents; D000970:Antineoplastic Agents; D011758:Pyrroles; C094409:pentabromopseudilin