Age-related changes in the noradrenergic pattern and receptor responses of the rat cardiovascular system after repeated microwave exposure.
In the present research the effect of repeated microwave exposure on the noradrenergic pattern by histofluorescence method and on receptor-mediated responses using alpha and beta agonists in myocardium and aorta of young-adult and aged rats was studied. Young-adult irradiated rats showed an increase in noradrenergic innervation more marked in myocardial tissue, while an increase in maximal response to the agonist was found only at aortic level. Aged stressed rats exhibited an increase in fluorescent fibres at atrial and aortic level, but in the atrial section this increase was found to be less evident than in young-adult animals. Functional data in aged rats revealed a more marked decrease in maximal response ratio (M.R.R.) of myocardial tissue than in young-adult rats, together with a noticeable decrease in maximal response at aortic level. These results indicate no direct correlation between morphological and functional data. Participation of both central and peripheral mechanisms is suggested.
Soldani
P
P
Istituto di Anatomia Normale, Facoltà di Medicina e Chirurgia, Università di Pisa, Italy.
Pellegrini
A
A
Gesi
M
M
Paparelli
A
A
Breschi
M C
MC
Scatizzi
R
R
Campagni
A
A
Del Bianchi
S
S
D000375:Aging / Q000502:physiology*; D000818:Animals; D002319:Cardiovascular System / Q000294:innervation / Q000528:radiation effects*; D006651:Histocytochemistry; D007545:Isoproterenol / Q000494:pharmacology; D008297:Male; D008872:Microwaves; D009638:Norepinephrine / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D011941:Receptors, Adrenergic / Q000528:radiation effects*; D013564:Sympathetic Nervous System / Q000033:anatomy & histology / Q000528:radiation effects*; D013566:Sympathomimetics / Q000494:pharmacology
D011941:Receptors, Adrenergic; D013566:Sympathomimetics; D007545:Isoproterenol; D009638:Norepinephrine