title: Diastolic runoff with widened arterial pulse pressure in an adolescent with widely metastatic testicular choriocarcinoma.
abstract: Widened arterial pulse pressure is often found with conditions having exaggerated diastolic runoff flow, such as aortic insufficiency and arteriovenous malformation. We report a 17-year-old boy with metastatic testicular choriocarcinoma and a widened pulse pressure. Ultrasonography and Doppler analysis revealed significant runoff flow into multiple large hepatic metastases. After chemotherapy, there was diminution in his metastases, a narrowing of the pulse pressure, and no evidence of runoff flow in the liver. These cardiovascular findings have not been previously described in association with metastatic vascular malignancies.
authors.affiliation: Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Murray
authors.forename: D
authors.initials: D
authors.lastname: Oshman
authors.forename: C P
authors.initials: CP
authors.lastname: Steuber
mesh_terms: D000293:Adolescent; D001794:Blood Pressure; D002822:Choriocarcinoma / Q000503:physiopathology*; D003971:Diastole; D006801:Humans; D008297:Male; D009362:Neoplasm Metastasis; D011674:Pulse; D013736:Testicular Neoplasms / Q000503:physiopathology*; D018608:Ultrasonography, Doppler