Toxicokinetics of ochratoxin A in rat following intratracheal administration.
The toxicokinetic parameters of ochratoxin A in rat following intratracheal administration of 50 ng ochratoxin A/g body weight were studied. The absorption of ochratoxin A from the lungs was very efficient. The elimination pattern of the toxin was studied by the analysis of blood samples. The biological half-life of ochratoxin A was 127 h and the calculated apparent volume of distribution equalled 168 ml/kg. The bioavailability of the toxin was very high, 98%. The plasma clearance of the toxin was 0.92 ml/kg.h.
Breitholtz-Emanuelsson
A
A
Department of Biochemistry and Biotechnology, Royal Institute of Technology, Stockholm, Sweden.
Fuchs
R
R
Hult
K
K
D000042:Absorption; D000280:Administration, Inhalation; D000818:Animals; D004032:Diet; D006207:Half-Life; D008168:Lung / Q000187:drug effects / Q000378:metabolism*; D008297:Male; D009793:Ochratoxins / Q000097:blood / Q000493:pharmacokinetics* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D014132:Trachea
D009793:Ochratoxins; C025589:ochratoxin A