Interferon-gamma in the management of infectious diseases.
Interferon-gamma has pleiotropic adjuvant effects on host defenses. These effects have made interferon-gamma particularly useful for enhancing host defenses in patients with chronic granulomatous disease of childhood and thus for reducing the incidence of life-threatening infections in these patients. Increasingly, data suggest that interferon-gamma will be useful for treating infections characterized by intracellular persistence in macrophages, such as toxoplasmosis, leishmaniasis, and mycobacteriosis. Interferon-gamma is emerging as an important cytokine for use in the treatment of infectious diseases.
Gallin
J I
JI
Warren G. Magnuson Clinical Center, National Institutes of Health, Bethesda, MD 20892-1504, USA.
Farber
J M
JM
Holland
S M
SM
Nutman
T B
TB
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D007239:Infections / Q000188:drug therapy* / Q000382:microbiology; D007371:Interferon-gamma / Q000494:pharmacology / Q000627:therapeutic use*; D008969:Molecular Sequence Data; D010272:Parasitic Diseases / Q000188:drug therapy; D011506:Proteins / Q000187:drug effects
D011506:Proteins; D007371:Interferon-gamma