Circadian variations of plasminogen activator activity, tissue-type plasminogen activator antigen, plasminogen activator inhibition and plasmin inhibition in rat aorta, heart and brain are influenced by endotoxin or aspirin or endotoxin plus aspirin.
The effect of aspirin or endotoxin or aspirin plus endotoxin on the circadian variations of plasminogen activator activity (PAA), tissue-type plasminogen activator (t-PA) antigen level, plasminogen activator inhibition (PAI) and plasmin inhibition (PI) in aorta, heart and brain of the rat was studied. In aorta the circadian variations of PAA, t-PA antigen and tissue-type PAI (t-PAI) were blunted by endotoxin, while the circadian variation of PI was reversed; t-PAI variation was blunted by aspirin plus endotoxin, while PI variation was reversed. Various disturbances of the circadian variations of PAA, t-PA antigen, PAI or PI in heart and brain were also observed. In conclusion, the circadian variations of fibrinolytic parameters in key organs are influenced by aspirin or endotoxin or aspirin plus endotoxin in a varying way or degree depending on the treatment, the parameter studied or the organ.
Kokolis
N
N
Department of Physiology, Faculty of Veterinary Medicine, Aristotelian University of Thessaloniki, Greece.
Rekkas
C
C
Tsandarliotou
M
M
Smokovitis
A
A
D000818:Animals; D001011:Aorta / Q000187:drug effects / Q000378:metabolism; D001241:Aspirin / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects / Q000378:metabolism; D002940:Circadian Rhythm; D004731:Endotoxins / Q000494:pharmacology*; D005341:Fibrinolysin / Q000037:antagonists & inhibitors / Q000187:drug effects* / Q000378:metabolism; D006321:Heart / Q000187:drug effects; D008297:Male; D009206:Myocardium / Q000378:metabolism; D010960:Plasminogen Activators / Q000187:drug effects / Q000378:metabolism; D015849:Plasminogen Inactivators / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D012697:Serine Endopeptidases / Q000187:drug effects* / Q000378:metabolism; D010959:Tissue Plasminogen Activator / Q000187:drug effects / Q000378:metabolism
D004731:Endotoxins; D015849:Plasminogen Inactivators; D010960:Plasminogen Activators; D012697:Serine Endopeptidases; D010959:Tissue Plasminogen Activator; D005341:Fibrinolysin; D001241:Aspirin