Primary varicella in adult renal transplant recipients: a report of three cases plus a review of the literature.
Disseminated primary varicella zoster infection in renal transplant patients can result in severe and often fatal illness. The disease tends to be much more severe in adults with an 80% mortality in the only reported series (1). We report 3 cases of severe disseminated varicella zoster in adult renal transplant patients who all survived. Early diagnosis, institution of intravenous acyclovir 10 mg/kg tds, zoster immunoglobulin, cessation of azathioprine treatment and aggressive supportive care may improve an otherwise bleak prognosis.
Parnham
A P
AP
Department of nephrology, Royal Perth Hospital, Western Australia.
Flexman
J P
JP
Saker
B M
BM
Thatcher
G N
GN
D000212:Acyclovir / Q000008:administration & dosage / Q000627:therapeutic use; D000328:Adult; D001379:Azathioprine / Q000008:administration & dosage / Q000627:therapeutic use; D002644:Chickenpox / Q000175:diagnosis / Q000188:drug therapy / Q000209:etiology*; D004211:Disseminated Intravascular Coagulation / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D014645:Herpesvirus 3, Human / Q000276:immunology; D006801:Humans; D007136:Immunoglobulins / Q000008:administration & dosage / Q000627:therapeutic use; D016030:Kidney Transplantation; D008297:Male
D007136:Immunoglobulins; D001379:Azathioprine; D000212:Acyclovir