title: Complex structure and regulation of the P16 (MTS1) locus.
abstract: The p16 gene (P16, MTS1, CDKN2) encodes a negative regulator of the cell cycle. Molecular genetic techniques have been used to explore the role of p16 in normal development and cancer. Two transcripts derived from the p16 gene with distinct protein coding potentials are described. The previously undescribed transcript form has the same exons 2 and 3 as the p16-encoding mRNA but contains a different exon 1. The human p16 transcripts are detected in various tissues, and the ratio of the transcripts is regulated in both a tissue-specific and cell cycle-specific manner. The P16-derived mRNAs are probably generated from separate promoters, and transcription from one of the promoters appears to be regulated, at least in part, by the retinoblastoma gene product.
authors.affiliation: Myriad Genetics, Inc., Salt Lake City, Utah 84018, USA.
authors.forename: S
authors.initials: S
authors.lastname: Stone
authors.forename: P
authors.initials: P
authors.lastname: Jiang
authors.forename: P
authors.initials: P
authors.lastname: Dayananth
authors.forename: S V
authors.initials: SV
authors.lastname: Tavtigian
authors.forename: H
authors.initials: H
authors.lastname: Katcher
authors.forename: D
authors.initials: D
authors.lastname: Parry
authors.forename: G
authors.initials: G
authors.lastname: Peters
authors.forename: A
authors.initials: A
authors.lastname: Kamb
mesh_terms: D001483:Base Sequence; D002352:Carrier Proteins / Q000235:genetics*; D019941:Cyclin-Dependent Kinase Inhibitor p16; D004252:DNA Mutational Analysis; D005091:Exons; D015972:Gene Expression Regulation, Neoplastic; D016147:Genes, Tumor Suppressor; D006801:Humans; D008214:Lymphocytes / Q000502:physiology; D008969:Molecular Sequence Data; D009369:Neoplasms / Q000235:genetics*; D011401:Promoter Regions, Genetic; D012333:RNA, Messenger / Q000235:genetics; D014158:Transcription, Genetic; D014407:Tumor Cells, Cultured
chemical_list: D002352:Carrier Proteins; D019941:Cyclin-Dependent Kinase Inhibitor p16; D012333:RNA, Messenger