Reversible acute renal failure due to sulfonamide-induced lithiasis in an AIDS patient.
OBJECTIVE
Drug-induced lithiasis was well-known some years ago, when sulfonamides poorly soluble in urine were in use. Now, they are again in use for some opportunistic AIDS-related infections. We report herein the case of an AIDS patient, treated with sulfadiazine because of Nocardia pneumonia, that came to the emergency room in acute renal failure.


RESULTS
Obstructive uropathy due to radiolucent calculi was suspected and retrograde ureteral catheterization was necessary. The calculi recovered were identified as N-acetyl sulfadiazine by infrared spectrophotometry.


CONCLUSIONS
Rapid improvement can be achieved in these patients when the drug is discontinued or decrease and systemic fluid and urine alkalinization are started.
Fariña
L A
LA
Urology Department, Fundacion Puigvert, Barcelona, Spain.
Palou Redorta
J
J
Chechile Toniolo
G
G
D017088:AIDS-Related Opportunistic Infections / Q000150:complications / Q000188:drug therapy; D000163:Acquired Immunodeficiency Syndrome / Q000150:complications*; D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000175:diagnosis; D000328:Adult; D015497:HIV-1; D006801:Humans; D007669:Kidney Calculi / Q000139:chemically induced* / Q000175:diagnosis; D008297:Male; D009617:Nocardia Infections / Q000150:complications / Q000188:drug therapy; D018410:Pneumonia, Bacterial / Q000150:complications / Q000188:drug therapy; D013411:Sulfadiazine / Q000008:administration & dosage / Q000009:adverse effects*
D013411:Sulfadiazine