Intracoronary stenting without coumadin: one month results of a French multicenter study.
In order to simplify post-coronary stenting treatment and to obtain a lower rate of complications, especially in bailout situations, seven French institutions treated 246 stented patients with 0.25 g/day of ticlopidine, 0.1 g/day of IV aspirin, and 2 days of heparin followed by low-molecular-weight heparin for 1 month. Fifty percent of patients had a planned stenting procedure, and 50% had an unplanned procedure, including 29 (11.8%) in bailout situations. Subacute occlusion occurred in three (1.2%) patients (one death, two non-Q-wave infarctions). During the 1 month follow-up period, another death was reported (non-stent-related), two elective coronary artery bypass grafts were performed, and three additional patients presented with non-Q-wave myocardial infarctions. Nine (3.7%) patients had a groin complication that required blood transfusion or surgical repair. These results suggest that while waiting for the technological advancements of stents, postprocedural treatment that includes a low dosage of ticlopidine, aspirin, and low-molecular-weight heparin is a very effective alternative to conventional poststenting therapy.
Morice
M C
MC
Centre Cardiologique du Nord, Saint-Denis, France.
Zemour
G
G
Benveniste
E
E
Biron
Y
Y
Bourdonnec
C
C
Faivre
R
R
Fajadet
J
J
Gaspard
P
P
Glatt
B
B
Joly
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015906:Angioplasty, Balloon, Coronary; D001241:Aspirin / Q000627:therapeutic use*; D003327:Coronary Disease / Q000628:therapy; D004359:Drug Therapy, Combination; D004562:Electrocardiography; D005260:Female; D005500:Follow-Up Studies; D006495:Heparin, Low-Molecular-Weight / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D015607:Stents; D013927:Thrombosis / Q000401:mortality / Q000517:prevention & control*; D013988:Ticlopidine / Q000627:therapeutic use*
D006495:Heparin, Low-Molecular-Weight; D013988:Ticlopidine; D001241:Aspirin