[Pulmonary-renal syndrome: diagnostic and therapeutic strategy].
The pulmonary-renal syndrome is defined by the association of alveolar hemorrhage and rapidly progressive glomerulonephritis. Goodpasture syndrome and necrotizing vasculitides are the most frequent causes. New serologic markers are currently more rapidly available (anti-glomerular basement membrane--anti-GBM--and antineutrophil cytoplasmic antibodies -ANCA), allowing clinicians to identify and distinguish these 2 entities, and to hasten the initiation of a pulse therapy, now well standardized, which improves the outcome of patients. However, these 2 serologic markers have limitations so that clinical assessment and renal biopsy remains essential in the diagnosis of pulmonary-renal syndrome. The authors propose an algorithmic approach for those confronted with such a condition.
Lefebvre
C
C
Département de Médecine Interne, Cliniques Universitaires St-Luc, Bruxelles.
Lambert
M
M
Pirson
Y
Y
D019867:Anti-Glomerular Basement Membrane Disease / Q000150:complications; D000906:Antibodies / Q000276:immunology; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies / Q000302:isolation & purification; D001485:Basement Membrane / Q000276:immunology; D015415:Biomarkers; D005921:Glomerulonephritis / Q000150:complications* / Q000276:immunology / Q000628:therapy; D006470:Hemorrhage / Q000150:complications*; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology; D008171:Lung Diseases / Q000150:complications* / Q000276:immunology / Q000628:therapy; D011650:Pulmonary Alveoli / Q000473:pathology; D013577:Syndrome; D014657:Vasculitis / Q000150:complications
D000906:Antibodies; D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D015415:Biomarkers; C051951:antiglomerular basement membrane antibody