title: Group A streptococcal necrotizing fasciitis following varicella in children: case reports and review.
abstract: We report four cases of necrotizing fasciitis that occurred following varicella in children ranging in age from 2 to 8 years. The only organism isolated from each of these patients was Streptococcus pyogenes or group A beta-hemolytic Streptococcus (GABHS). Each child recovered; however, three required repeated surgical debridements in addition to therapy with antibiotics. An interesting finding in these patients was the development of hyponatremia and/or hypocalcemia. M-typing and T-typing of the isolates demonstrated that the GABHS strain in two children who attended the same school was M5; M1 and M3 strains were identified in the other two children. In addition to the children described in this series, eleven other cases of children with necrotizing fasciitis following varicella have been reported in the English-language literature since 1970. We believe that these cases provide further evidence that varicella is an important risk factor for necrotizing fasciitis that is caused by more-virulent strains of GABHS.
authors.affiliation: Department of Pediatrics, Vanderbilt Medical School, Nashville, Tennessee 37232, USA.
authors.forename: G J
authors.initials: GJ
authors.lastname: Wilson
authors.forename: D F
authors.initials: DF
authors.lastname: Talkington
authors.forename: W
authors.initials: W
authors.lastname: Gruber
authors.forename: K
authors.initials: K
authors.lastname: Edwards
authors.forename: T S
authors.initials: TS
authors.lastname: Dermody
mesh_terms: D002644:Chickenpox / Q000150:complications*; D002648:Child; D002675:Child, Preschool; D005208:Fasciitis / Q000209:etiology*; D005260:Female; D006801:Humans; D008297:Male; D009336:Necrosis; D013290:Streptococcal Infections / Q000209:etiology*; D013297:Streptococcus pyogenes