Mutagenic activity of dopamine after nitrosation.
Dopamine hydrochloride is reported to be a new mutagen precursor in this study. After treatment with nitrite under acidic conditions, dopamine hydrochloride showed direct-acting mutagenicity on Salmonella typhimurium TA100, TA98 and Escherichia coli WP2uvra. The addition of S9 mix did not affect the mutagenicity of nitrosated dopamine significantly in these three strains. Meanwhile, a comparison of the mutagenicity of nitrosated dopamine with nitrosated tyramine was carried out.
Su
C
C
Department of Nutrition and Food Hygiene, Public Health College, Harbin Medical University, People's Republic of China.
Chen
B
B
Wang
S
S
Liu
Z
Z
D004298:Dopamine / Q000737:chemistry / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D009152:Mutagenicity Tests; D009153:Mutagens / Q000737:chemistry*; D009573:Nitrites / Q000737:chemistry / Q000633:toxicity*; D015538:Nitrosation; D012486:Salmonella typhimurium / Q000187:drug effects; D014439:Tyramine / Q000633:toxicity
D009153:Mutagens; D009573:Nitrites; D004298:Dopamine; D014439:Tyramine