Clinical efficiency of type-IV collagen in extracorporeal shock wave lithotripsy.
We previously reported a patient who developed anti-glomerular basement membrane antibody-induced glomerulonephritis (GBM-GN) after extracorporeal shock wave lithotripsy (ESWL). To determine whether ESWL causes anti-GBM antibody production thereby inducing GBM-GN, we measured serum levels of type-IV collagen (the most major component of GBM) before and after ESWL. Serum samples were obtained from 13 patients with renal stones and 15 with ureteral stones. The serum type-IV collagen level was determined by a radioimmunoassay method. No significant changes were observed in the type-IV collagen level after ESWL in each patient group. Type-IV collagen was abundant in the GBM but was not released into the blood after ESWL. Therefore, in patients with urinary tract stones, it is not likely that type-IV collagen, a hidden antigen in the renal glomeruli, is exposed or released into the blood after ESWL, resulting in autoantibody production and GBM-GN.
Umekawa
T
T
Department of Urology, Kinki University School of Medicine, Osaka, Japan.
Yamate
T
T
Amasaki
N
N
Kurita
T
T
D000328:Adult; D003094:Collagen / Q000097:blood*; D005260:Female; D006801:Humans; D008096:Lithotripsy; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D014514:Ureteral Calculi / Q000097:blood* / Q000628:therapy
D003094:Collagen