Bistability and damped oscillations in the fructose 6-phosphate/fructose 1,6-bisphosphate cycle in cell-free extracts from rat liver.
The dynamics of the fructose 6-phosphate/fructose 1,6-bisphosphate substrate cycle was investigated in cell-free extracts from rat liver. Under conditions of continuous substrate supply different types of stationary states and damped oscillations were observed experimentally and found to be in qualitative agreement with theoretical predictions. Changing the adenylate energy charge of the substrate supply, bistability was shown to be related to irreversible transitions between functionally different branches of stable stationary states.
Frenzel
J
J
Institut für Biochemie, Medizinische Fakultät, Universität Leipzig, Germany.
Schellenberger
W
W
Eschrich
K
K
D000818:Animals; D002474:Cell-Free System; D003198:Computer Simulation; D004789:Enzyme Activation; D006597:Fructose-Bisphosphatase / Q000737:chemistry / Q000378:metabolism; D005635:Fructosediphosphates / Q000737:chemistry / Q000378:metabolism*; D005636:Fructosephosphates / Q000737:chemistry / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008954:Models, Biological; D010732:Phosphofructokinase-1 / Q000737:chemistry / Q000378:metabolism; D051381:Rats
D005635:Fructosediphosphates; D005636:Fructosephosphates; C027618:fructose-6-phosphate; D010732:Phosphofructokinase-1; D006597:Fructose-Bisphosphatase; C029063:fructose-1,6-diphosphate