Effects of KCA-012 on bone metabolism in organ culture.
3,9-Dihydroxy-5H-benzofuro[3,2-c]quinoline-6-one (KCA-012), the chemical structure of which is closely similar to that of the phytoestrogen coumestrol, inhibited parathyroid hormone-, 1 alpha,25-dihydroxyvitamin D3- and prostaglandin E2-induced bone resorption of cultured fetal rat bones. KCA-012 also increased the calcium content of 9-day chick embryonic femur cultured in vitro. KCA-012 did not show any estrogenic activity as determined by an increase in the uterine weight of ovariectomized rats, whereas coumestrol did. These results indicate that KCA-012 has no estrogenic activity and has unique effects of inhibiting bone resorption and stimulating bone mineralization.
Tsutsumi
N
N
Central Research Laboratories, Kissei Pharmaceutical Co., Ltd., Nagano, Japan.
Kawashima
K
K
Nagata
H
H
Ujiie
A
A
Endo
H
H
D000818:Animals; D001842:Bone and Bones / Q000187:drug effects* / Q000378:metabolism*; D002118:Calcium / Q000378:metabolism; D003375:Coumestrol / Q000737:chemistry / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D009924:Organ Culture Techniques; D011804:Quinolines / Q000494:pharmacology*; D051381:Rats; D014599:Uterus / Q000187:drug effects
D011804:Quinolines; C037219:quinoline; D002118:Calcium; D003375:Coumestrol