title: HIV-1 incidence and HIV-1 associated mortality in a cohort of urban factory workers in Tanzania.
abstract: OBJECTIVE
  To determine HIV-1 incidence and HIV-1 associated mortality in a prospective cohort study. To determine whether the cohort is suitable for studies aiming to determine the impact of interventions on HIV-1 incidence.
  
  
  METHODS
  The study population was a cohort of 1772 urban factory workers (1478 men and 294 women) in northwest Tanzania. The study took place from October 1991 to September 1993. Outcome measures were HIV-1 seroconversion and death.
  
  
  RESULTS
  HIV-1 incidence was 1.2 (95% CI 0.7-2.0) per 100 person-years (pyr). Crude annual mortality was 4.9 per 100 pyr in those with and 0.3 in those without HIV-1 infection, giving an age and sex adjusted mortality ratio of 12.9 (95% CI 5.4-30.7). Of all deaths, 62% were attributable to HIV-1 infection.
  
  
  CONCLUSIONS
  HIV-1 infection was a major public health problem, being the major cause of death in this adult population. At an HIV-1 incidence of 1.2 per 100 pyr, a large cohort size would be required to evaluate the impact of interventions on HIV-1 incidence.
authors.affiliation: National Institute for Medical Research, Mwanza, Tanzania.
authors.forename: M W
authors.initials: MW
authors.lastname: Borgdorff
authors.forename: L R
authors.initials: LR
authors.lastname: Barongo
authors.forename: A H
authors.initials: AH
authors.lastname: Klokke
authors.forename: J N
authors.initials: JN
authors.lastname: Newell
authors.forename: K P
authors.initials: KP
authors.lastname: Senkoro
authors.forename: J P
authors.initials: JP
authors.lastname: Velema
authors.forename: R M
authors.initials: RM
authors.lastname: Gabone
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015331:Cohort Studies; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000401:mortality*; D015497:HIV-1; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D015995:Prevalence; D011897:Random Allocation; D012307:Risk Factors; D015996:Survival Rate; D013636:Tanzania / Q000453:epidemiology; D014504:Urban Health