Metal ion interaction with penicillins--Part VII: Mixed-ligand complex formation of cobalt(II), nickel(II), copper(II), and Zinc(II) with ampicillin and nucleic bases.
Equilibrium study on the mixed-ligand complex formation of M2+ ions (M = Co, Ni, Cu, and Zn) with alpha-d-(-)aminobenzyl penicillin popularly known as ampicillin, (hereafter, ampH +/-), and nucleic bases, viz. adenine, guanine, thymine, uracil, and cytosine (B), in aqueous solution at 37 degrees C at a fixed ionic strength, I = 0.1 M (NaNO3) indicates the formation of complexes of the types: M(amp), M(B), M(amp)(B), M(H-1 amp)(B), and M(H-1 amp)(B)(OH). Stability constants of the ternary complexes are in the order: Co2+ < Ni2+ < Cu2+ > Zn2+ with regard to the mental ions and guanine > adenine > uracil > thymine > cytosine with regard to the nucleic bases. Complex formation equilibria have been worked out on the basis of species distribution curves.
Mukherjee
G
G
Department of Chemistry, University College of Science, Calcutta, India.
Ghosh
T
T
D000667:Ampicillin / Q000737:chemistry*; D003035:Cobalt / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D006863:Hydrogen-Ion Concentration; D007700:Kinetics; D008024:Ligands; D008670:Metals / Q000737:chemistry*; D008956:Models, Chemical; D009532:Nickel / Q000737:chemistry; D009942:Organometallic Compounds / Q000737:chemistry*; D009994:Osmolar Concentration; D011687:Purines / Q000737:chemistry*; D011743:Pyrimidines / Q000737:chemistry*; D015032:Zinc / Q000737:chemistry
D008024:Ligands; D008670:Metals; D009942:Organometallic Compounds; D011687:Purines; D011743:Pyrimidines; D003035:Cobalt; D003300:Copper; D000667:Ampicillin; D009532:Nickel; D015032:Zinc