Efficacy of treatment of murine Schistosoma mansoni infections with praziquantel and oxamniquine correlates with infection intensity: role of host antibody.
The reduction in worm burden obtained by treatment of Schistosoma mansoni with praziquantel and oxamniquine was greater in mice with heavy infections than in relatively lightly infected animals. The reduction in worm burden achieved by each drug correlated with the size of the pre-treatment worm burden (r2 = 0.82 and 0.81 for praziquantel and oxamniquine, respectively). Intensity of infection did not affect the degree of tegumental damage and drug-induced antigen exposure on worms recovered soon after treatment with praziquantel. However, praziquantel-treated worms from mice with heavy infections had significantly more murine antibody attached to the treated-worm surface than worms from praziquantel-treated lightly infected mice. Heavily infected mice had greater levels of circulating anti-worm antibodies than lighter infected mice. The correlation between infection intensity and cure rates achieved by praziquantel and oxamniquine may thus be a reflection of the higher titres of relevant antibody in heavily infected mice mediating death of drug-treated worms.
Fallon
P G
PG
School of Biological Sciences, University of Wales, Bangor, Gwynedd, UK.
Hamilton
J V
JV
Doenhoff
M J
MJ
D000818:Animals; D000909:Antibodies, Helminth / Q000032:analysis* / Q000097:blood; D000953:Antigens, Protozoan / Q000032:analysis; D005260:Female; D008297:Male; D051379:Mice; D010073:Oxamniquine / Q000627:therapeutic use*; D011223:Praziquantel / Q000494:pharmacology / Q000627:therapeutic use*; D012550:Schistosoma mansoni / Q000187:drug effects / Q000276:immunology* / Q000648:ultrastructure; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000469:parasitology
D000909:Antibodies, Helminth; D000953:Antigens, Protozoan; D010073:Oxamniquine; D011223:Praziquantel