Nuclear tau immunoreactivity in presenile dementia with motor neuron disease: a case report.
We report for the first time localization of tau immunoreactivity with neuronal nuclei in an autopsy case of a 64-year-old white male with a 10-year history of presenile dementia with motor neuron disease. The anti-tau mAbs Tau-1, Tau-2, Tau-5 and PHF-1 and the anti-phosphoneurofilament mAb SMI-31, which crossreacts with tau, stained neuronal nuclei in neocortical pyramidal layer V or in layer III of primary motor cortex, in the periamygdaloid and entorhinal cortices, in pons and in a few paramedian neurons in dorsal medulla. The staining was excluded from nucleoli.
Papasozomenos
S C
SC
Department of Pathology, University of Texas-Houston Medical School 77030, USA.
D000679:Amygdala / Q000473:pathology; D000911:Antibodies, Monoclonal; D001921:Brain / Q000473:pathology*; D002467:Cell Nucleus / Q000473:pathology; D002540:Cerebral Cortex / Q000473:pathology; D003704:Dementia / Q000473:pathology*; D018728:Entorhinal Cortex / Q000473:pathology; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009044:Motor Cortex / Q000473:pathology; D016472:Motor Neuron Disease / Q000473:pathology*; D009474:Neurons / Q000473:pathology; D016875:tau Proteins / Q000032:analysis*
D000911:Antibodies, Monoclonal; D016875:tau Proteins