[alpha-Interferon therapy in a patient with renal cell carcinoma and renal hypofunction].
A 60-year-old man who had renal cell carcinoma with renal hypofunction underwent partial nephrectomy followed by alpha-interferon therapy (LHBI 3 x 10(6) IU/day intramuscular injection for 4 weeks, then twice a week for 6 months). Glomerular filtration rate slightly decreased to 28. 5 from 32.6 ml/m after partial nephrectomy. On single injection of IFN, its serum level reached the maximum of 20.3 IU/ml, at 12 hours of injection, and 10.4 IU/ml at 24 hours. After 4 weeks, that was 50.6 IU/ml. NK activity and ADCC which were 32, and 68%, respectively before treatment, reduced to 6, and 28%, respectively after 4 weeks. After maintenance therapy they were shown to rise up to 26, and respectively 73%, and increased immunoactivity was confirmed.
Noguchi
R
R
Department of Urology, Mito Saiseikai General Hospital.
Tomobe
M
M
Akaza
H
H
Koiso
K
K
D002292:Carcinoma, Renal Cell / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D005919:Glomerular Filtration Rate; D006801:Humans; D007273:Injections, Intramuscular; D016898:Interferon-alpha / Q000627:therapeutic use*; D007680:Kidney Neoplasms / Q000503:physiopathology / Q000601:surgery / Q000628:therapy*; D016131:Lymphocyte Subsets / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009392:Nephrectomy; D051437:Renal Insufficiency / Q000503:physiopathology*
D016898:Interferon-alpha