title: [Thalassemic alleles in Mexican mestizos].
abstract: We present an analysis of the thalassemic alleles observed in Mexican mestizos. In 18 unrelated patients with mild to severe hemolytic anemia we saw 16 with beta-thal and two with alpha-thal and identified 25 chromosomes with 14 different alleles (10 for beta-thal), predominating the Mediterranean type (seven beta-thal and two alpha-thal). The most common mutation was the nonsense Cd 39 observed in seven chromosomes (28%); the other mutants were three Asian alleles, one beta-thal Indian (IVS-1 nt 5 G-->C), two Southeast Asian alpha-thal (-SEA and the -FIL), one Kurdish Jew (-28 A-->C) and one Mexican (Cd 11 -T). These findings suggest a marked molecular heterogeneity in the thalassemia genes in Mexico.
authors.affiliation: División de Genética, Centro Médico Nacional de Occidente, IMSS, Guadalajara, Jalisco.
authors.forename: B
authors.initials: B
authors.lastname: Ibarra
authors.forename: F J
authors.initials: FJ
authors.lastname: Perea
authors.forename: A R
authors.initials: AR
authors.lastname: Villalobos-Arámbula
mesh_terms: D000328:Adult; D000483:Alleles; D001208:Asia / Q000208:ethnology; D002648:Child; D005060:Europe / Q000208:ethnology; D005260:Female; D005914:Globins / Q000235:genetics*; D006801:Humans; D007585:Jews / Q000235:genetics; D008297:Male; D008800:Mexico / Q000453:epidemiology; D017354:Point Mutation; D017085:alpha-Thalassemia / Q000208:ethnology / Q000235:genetics; D017086:beta-Thalassemia / Q000208:ethnology* / Q000235:genetics*
chemical_list: D005914:Globins