Correlation of differentiation-inducing activity of retinoids on human leukemia cell lines HL-60 and NB4.
Retinoids, including all-trans-retinoic acid, its isomers, and fifty synthetic retinoids (retinobenzoic acids), were tested for differentiation-inducing activity on human leukemia cell lines HL-60 and NB4. A good linear correlation, with an r value of 0.91, between the ED50 values for the differentiation-inducing activity towards HL-60 cells and that towards NB4 cells was found.
Hashimoto
Y
Y
Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan.
Kagechika
H
H
Kawachi
E
E
Fukasawa
H
H
Saito
G
G
Shudo
K
K
D002454:Cell Differentiation / Q000187:drug effects; D002471:Cell Transformation, Neoplastic / Q000187:drug effects*; D002884:Chromosomes, Human, Pair 15; D002886:Chromosomes, Human, Pair 17; D004354:Drug Screening Assays, Antitumor; D015973:Gene Expression Regulation, Leukemic / Q000187:drug effects; D006098:Granulocytes; D006801:Humans; D016018:Least-Squares Analysis; D015473:Leukemia, Promyelocytic, Acute / Q000473:pathology*; D018168:Receptors, Retinoic Acid / Q000235:genetics; D012176:Retinoids / Q000494:pharmacology*; D014178:Translocation, Genetic; D014212:Tretinoin / Q000494:pharmacology; D014407:Tumor Cells, Cultured / Q000187:drug effects
D018168:Receptors, Retinoic Acid; D012176:Retinoids; D014212:Tretinoin