Primary cutaneous CD30(Ki-1)-positive lymphoma of non-T, non-B origin.
A 71-year-old Japanese woman had two dome-shaped tumors on her right buttock with several surrounding papules. Histological examination revealed that large anaplastic cells and atypical lymphoid cells densely infiltrated the entire dermis. On immunohistochemical examination, Ki-1, HLA-DR, CD25 (IL-2 receptor alpha), CD122 (IL-2 receptor beta), CD4, CD11c and CD68 were all positive in the tumor cells, whereas CD1a, CD3, CD5, CD8 and CD19 were negative. Neither rearrangement of the T-cell receptor beta, T-cell receptor gamma nor the immunoglobulin heavy-chain was seen. Ultrastructurally, most of the tumor cells contained thick bundles of intermediate filaments in the perinuclear cytoplasm. Thus, this patient was diagnosed as having Ki-1-positive lymphoma of non-T, non-B origin. No recurrence or metastasis of the tumor has been observed in the last 2 years, although surgical resection was required 3 times before control was achieved.
Akiyama
C
C
Department of Dermatology, Yamanashi Medical University, Japan.
Shibagaki
N
N
Yasaka
N
N
Ohtake
N
N
Kubota
Y
Y
Takayama
O
O
Katoh
R
R
Shimada
S
S
Furue
M
M
Tamaki
K
K
D000368:Aged; D015703:Antigens, CD / Q000032:analysis; D015214:Antigens, Differentiation, Myelomonocytic / Q000032:analysis; D002081:Buttocks; D015704:CD4 Antigens / Q000032:analysis; D003593:Cytoplasm / Q000648:ultrastructure; D005260:Female; D006684:HLA-DR Antigens / Q000032:analysis; D006801:Humans; D016167:Integrin alphaXbeta2 / Q000032:analysis; D007382:Intermediate Filaments / Q000648:ultrastructure; D017730:Ki-1 Antigen / Q000032:analysis; D017728:Lymphoma, Large-Cell, Anaplastic / Q000473:pathology*; D015375:Receptors, Interleukin-2 / Q000032:analysis; D012878:Skin Neoplasms / Q000473:pathology*; D000097382:CD68 Molecule
D015703:Antigens, CD; D015214:Antigens, Differentiation, Myelomonocytic; D015704:CD4 Antigens; D006684:HLA-DR Antigens; D016167:Integrin alphaXbeta2; D017730:Ki-1 Antigen; D015375:Receptors, Interleukin-2; C067980:CD68 antigen, human; D000097382:CD68 Molecule