title: [Influence of the 2nd and 3rd grade abstracts from scorpion venom of Buthus martensii Karsch on action potentials of fast response myocardiocytes].
abstract: OBJECTIVE
  To screen the active components of sodium channel blockade action from Buthus martensii Karsch (BMK) scorpion venom.
  
  
  METHODS
  Myocardiocytes of mice were cultured. Action potentials of fast response myocardiocytes were recorded. The effects of 22 contents of BMK scorpion venom in a concentration of 3 mg.L-1 were tested and compared with that of TTX 2.5 mg.L-1, nimodipine (Nim) 3 mg.L-1 and BaCl2 24.4 mg.L-1.
  
  
  RESULTS
  BMK-1 and other 19 contents significantly decreased depolarization parameters Vmax, APA, OS, and MDP, which was similar to that of TTX and different from that of Nim and BaCl2.
  
  
  CONCLUSIONS
  The variations in the action potentials of fast response myocardiolcytes indicated that 20 contents of BMK scorpion venom had sodium channel blockade action.
authors.affiliation: Central Laboratory of Physiology, Norman Bethune University of Medical Sciences, Changchun, China.
authors.forename: Y
authors.initials: Y
authors.lastname: Jiang
authors.forename: W
authors.initials: W
authors.lastname: Liu
authors.forename: G G
authors.initials: GG
authors.lastname: Zhong
authors.forename: S J
authors.initials: SJ
authors.lastname: Yang
authors.forename: W J
authors.initials: WJ
authors.lastname: Zhang
authors.forename: J J
authors.initials: JJ
authors.lastname: Wei
authors.forename: H J
authors.initials: HJ
authors.lastname: Zhang
authors.forename: L
authors.initials: L
authors.lastname: Wang
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D002478:Cells, Cultured; D051379:Mice; D009206:Myocardium / Q000166:cytology*; D012604:Scorpion Venoms / Q000494:pharmacology*
chemical_list: D012604:Scorpion Venoms