title: Prospective multicenter evaluation of cocaine-associated chest pain. Cocaine Associated Chest Pain (COCHPA) Study Group.
abstract: OBJECTIVE
  To describe a large cohort of patients who had chest pain following cocaine use, and to determine the incidence of and clinical characteristics predictive for myocardial infarction in this group of patients.
  
  
  METHODS
  A prospective observational cohort study of consecutive patients with cocaine-associated chest pain was conducted in six municipal hospital emergency departments (EDs). Demographic variables, drug abuse patterns, medical histories, chest pain characteristics, ECG results, and laboratory data were recorded. Myocardial infarction was the primary endpoint.
  
  
  RESULTS
  Fourteen of 246 patients (5.7%; 95% confidence interval [CI], 2.7-8.7%) had myocardial infarction, as diagnosed by elevated CK-MB isoenzyme levels. There were two deaths (0.8%). The patients had a median age of 33 years. The majority were male (71.5%), non-white (83.3%), cigarette smokers (83.3%) who used cocaine regularly. Chest pain began a median of 60 minutes after cocaine use and persisted for a median of 120 minutes. Chest pain was most frequently described as substernal (71.3%) and pressure-like (46.7%). Shortness of breath (59.3%) and diaphoresis (38.6%) were common. There was no clinical difference between patients who had myocardial infarctions and those who did not. Twelve patients had arrhythmias and four had congestive heart failure. All cases requiring intervention were evident upon presentation. An ECG revealing ischemia or infarction had a sensitivity of 35.7% for predicting a myocardial infarction. The specificity, positive predictive value, and negative predictive value of the ECGs were 89.9%, 17.9%, and 95.8%, respectively.
  
  
  CONCLUSIONS
  Myocardial infarction in patients who have cocaine-associated chest pain is not uncommon. No clinical parameter available to the physician can adequately identify patients at very low risk for myocardial infarction. Therefore, all patients with cocaine-associated chest pain should be evaluated for myocardial infarction.
authors.affiliation: Department of Emergency Medicine University Hospital, State University of New York Stony Brook 11794-7400, USA.
authors.forename: J E
authors.initials: JE
authors.lastname: Hollander
authors.forename: R S
authors.initials: RS
authors.lastname: Hoffman
authors.forename: P
authors.initials: P
authors.lastname: Gennis
authors.forename: P
authors.initials: P
authors.lastname: Fairweather
authors.forename: M J
authors.initials: MJ
authors.lastname: DiSano
authors.forename: D A
authors.initials: DA
authors.lastname: Schumb
authors.forename: J A
authors.initials: JA
authors.lastname: Feldman
authors.forename: S S
authors.initials: SS
authors.lastname: Fish
authors.forename: S
authors.initials: S
authors.lastname: Dyer
authors.forename: P
authors.initials: P
authors.lastname: Wax
mesh_terms: D000328:Adult; D002637:Chest Pain / Q000139:chemically induced*; D003042:Cocaine / Q000009:adverse effects*; D004562:Electrocardiography; D004630:Emergencies; D005260:Female; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000139:chemically induced* / Q000175:diagnosis; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D019966:Substance-Related Disorders
chemical_list: D003042:Cocaine