title: [Effect of low doses of radiation on hematopoiesis in the liver of the human embryo and fetus during the first pregnancy trimester].
abstract: Percentage and mitotic regimen (mitotic index, mitotic phases, pathological mitosis) of hematopoietic liver cells of the embryos and foetuses (6-12 weeks of development) from females living in normal conditions (Moscow) and in polluted with radionuclides after Chernobyl accident territory of Bryansk region of Russian Federation (towns Novozybkov and Klintsy) are characterized. Moderate but statistically significant (P < 0.05) differences were found in the number of polychromatophilic and oxyphilic normoblasts, basophilic megaloblasts, granulocytes at various developmental stages in the study group compared to the control. No difference was observed in 1992 in the mitotic activity, total number of pathological mitoses and the percentage of binuclear cells. But the spectrum of pathological mitoses, in the contaminated zone, seems to be wider. The mitotic index and the number of cells per 1 mg of organ tissue showed two-fold increase in 1993 in the town of Novozybkov as compared to the control area. The conclusion is made that small radiation doses exert only very slight influence on hematopoiesis in human embryonic and foetal liver of 6-12 weeks of gestation.
authors.forename: O P
authors.initials: OP
authors.lastname: Riabchikov
authors.forename: S P
authors.initials: SP
authors.lastname: Shmeleva
authors.forename: N A
authors.initials: NA
authors.lastname: Chuich
authors.forename: Z S
authors.initials: ZS
authors.lastname: Khlystova
authors.forename: I I
authors.initials: II
authors.lastname: Kalinina
authors.forename: E L
authors.initials: EL
authors.lastname: Rabotnikova
authors.forename: I S
authors.initials: IS
authors.lastname: Sibakova
authors.forename: G I
authors.initials: GI
authors.lastname: Gerasiuta
authors.forename: E V
authors.initials: EV
authors.lastname: Lobusov
mesh_terms: D004307:Dose-Response Relationship, Radiation; D004622:Embryo, Mammalian / Q000528:radiation effects; D005314:Embryonic and Fetal Development / Q000528:radiation effects; D005260:Female; D006410:Hematopoiesis / Q000528:radiation effects*; D006801:Humans; D008099:Liver / Q000196:embryology / Q000528:radiation effects*; D009031:Moscow; D011210:Power Plants; D011247:Pregnancy; D011261:Pregnancy Trimester, First; D018788:Radioactive Hazard Release; D014455:Ukraine