Responses of substantia nigra pars reticulata and globus pallidus complex to high frequency stimulation of the subthalamic nucleus in rats: electrophysiological data.
High frequency stimulation of the subthalamic nucleus (STN-HFS) has been shown to reverse parkinsonian motor symptoms in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. We have studied the effect of STN-HFS on the spontaneous activity of the substantia nigra pars reticulata (SNr), entopeduncular nucleus (EP) and globus pallidus (GP) in rats. STN-HFS induced a decrease in activity of 91% of SNr cells, a suppression of activity in 80% of EP cells and an activation of 100% of GP recorded cells. These results show that STN-HFS exerts an inhibitory influence on the basal ganglia output structures similar to that obtained by STN lesion.
Benazzouz
A
A
Laboratoire de Neurobiophysique, UJFG, INSERM U.318, Centre Hospitalier Universitaire de Grenoble, France.
Piallat
B
B
Pollak
P
P
Benabid
A L
AL
D000818:Animals; D001479:Basal Ganglia / Q000502:physiology; D004558:Electric Stimulation; D004594:Electrophysiology; D005917:Globus Pallidus / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000502:physiology*; D013787:Thalamic Nuclei / Q000502:physiology*