title: Fertility after bone marrow transplantation following conditioning with cyclophosphamide and total body irradiation.
abstract: We report here two male patients who regained fertility after BMT following conditioning with cyclophosphamide and total body irradiation (TBI). Both patients received single fraction TBI. Recovery of fertility led to a pregnancy in both cases. These and three other previously reported cases are discussed.
authors.affiliation: Department of Haematology, Queen Elizabeth Hospital, Birmingham, UK.
authors.forename: A
authors.initials: A
authors.lastname: Jacob
authors.forename: A
authors.initials: A
authors.lastname: Goodman
authors.forename: J
authors.initials: J
authors.lastname: Holmes
mesh_terms: D000208:Acute Disease; D000328:Adult; D016026:Bone Marrow Transplantation; D003520:Cyclophosphamide / Q000009:adverse effects*; D005298:Fertility / Q000187:drug effects / Q000528:radiation effects; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000628:therapy*; D007951:Leukemia, Myeloid / Q000628:therapy*; D008297:Male; D014916:Whole-Body Irradiation / Q000009:adverse effects*
chemical_list: D003520:Cyclophosphamide