Insulin-like growth factors and cancer.
The insulin-like growth factor (IGF) family of peptides, binding proteins, and receptors are important for normal human growth and development and are involved in the specialized functions of most physiologic systems. Most members of the IGF system are expressed by different cancer cells and may play an important role in the propagation of these malignancies. New therapies aimed at modulating various components of the IGF system could affect the progression and metastasis of cancer.
LeRoith
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D
Molecular and Cellular Physiology Section, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892.
Baserga
R
R
Helman
L
L
Roberts
C T
CT
D000818:Animals; D002352:Carrier Proteins / Q000502:physiology; D002455:Cell Division / Q000502:physiology; D006801:Humans; D009369:Neoplasms / Q000503:physiopathology*; D017451:Receptors, Somatomedin / Q000502:physiology; D013002:Somatomedins / Q000502:physiology*
D002352:Carrier Proteins; D017451:Receptors, Somatomedin; D013002:Somatomedins