title: Adaptive preservation of ATP and tolerance to hypoxia following carotid artery ligation in the immature rat.
abstract: To investigate the adaptive mechanisms following carotid artery ligation in immature rats, histologic injury and tissue levels of ATP were compared after exposure to identical episodes of hypoxia induced either 3 or 24 h postligation. Histologic injury, assessed in both 9-day- and 23-day-postnatal animals after survival for 1 week, was markedly diminished in animals exposed to hypoxia 24 h postligation compared to that in animals exposed to hypoxia 3 h postligation. In 9-day-postnatal animals, ATP levels in the cerebral cortex ipsilateral to the ligation were depleted during hypoxia to 0.39 +/- 0.49 mmol/kg (mean +/- SD; N = 15) in animals exposed to hypoxia 3 h postligation but were maintained at 2.04 +/- 0.26 mmol/g (N = 18; p < 0.001) in animals exposed to hypoxia 24 h postligation. Thus, preservation of ATP may account for the diminution of cellular injury that results from delaying the onset of hypoxia from 3 to 24 h after carotid artery ligation in immature rats.
authors.affiliation: Division of Neurosurgery, University of Pennsylvania School of Medicine, Philadelphia, USA.
authors.forename: C M
authors.initials: CM
authors.lastname: Hylton
authors.forename: M A
authors.initials: MA
authors.lastname: Pesenson
authors.forename: F A
authors.initials: FA
authors.lastname: Welsh
mesh_terms: D000222:Adaptation, Physiological; D000255:Adenosine Triphosphate / Q000378:metabolism*; D000375:Aging / Q000378:metabolism; D000693:Anaerobiosis; D000818:Animals; D000831:Animals, Newborn; D002545:Brain Ischemia / Q000378:metabolism*; D017536:Carotid Artery, Common; D000860:Hypoxia / Q000378:metabolism*; D008026:Ligation; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
chemical_list: D000255:Adenosine Triphosphate