Manic-depression and the norepinephrine transporter gene.
Six multigenerational pedigrees containing multiple cases of manic-depression were genotyped with a DNA polymorphism for the norepinephrine transporter (NET) gene. Using both parametric and nonparametric methods, no evidence of linkage between manic-depression and the NET gene was found.
Hadley
D
D
Department of Psychiatry, University of Utah Medical Center, Salt Lake City.
Hoff
M
M
Holik
J
J
Reimherr
F
F
Wender
P
P
Coon
H
H
Byerley
W
W
D000293:Adolescent; D000328:Adult; D001714:Bipolar Disorder / Q000235:genetics*; D002352:Carrier Proteins / Q000235:genetics*; D005260:Female; D006801:Humans; D008126:Lod Score; D008297:Male; D050484:Norepinephrine Plasma Membrane Transport Proteins; D010375:Pedigree; D012150:Polymorphism, Restriction Fragment Length; D027981:Symporters
D002352:Carrier Proteins; D050484:Norepinephrine Plasma Membrane Transport Proteins; C493227:SLC6A2 protein, human; D027981:Symporters