Molecular approaches to amyotrophic lateral sclerosis.
New discoveries are expanding our knowledge of mechanisms involved in amyotrophic lateral sclerosis (ALS) pathogenesis. Some recent advances in our understanding of motoneuron death in familial ALS (fALS) and sporadic ALS (sALS) are reviewed, with emphasis on molecular similarities that may further unite these phenotypically linked diseases.
Smith
R G
RG
Department of Neurology, Baylor College of Medicine, Houston, Texas 77030, USA.
Appel
S H
SH
D000690:Amyotrophic Lateral Sclerosis / Q000235:genetics* / Q000401:mortality / Q000503:physiopathology; D001327:Autoimmune Diseases / Q000235:genetics / Q000401:mortality / Q000503:physiopathology; D005609:Free Radicals; D018698:Glutamic Acid / Q000502:physiology; D006801:Humans; D007527:Isoenzymes / Q000235:genetics; D009046:Motor Neurons / Q000502:physiology; D009154:Mutation; D009410:Nerve Degeneration / Q000235:genetics / Q000502:physiology; D010641:Phenotype; D013482:Superoxide Dismutase / Q000235:genetics; D015996:Survival Rate
D005609:Free Radicals; D007527:Isoenzymes; D018698:Glutamic Acid; D013482:Superoxide Dismutase