title: Late graft failure due to dual bone marrow infection with variants A and B of human herpesvirus-6.
abstract: Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6.
authors.affiliation: Texas Oncology, Dallas, USA.
authors.forename: C S
authors.initials: CS
authors.lastname: Rosenfeld
authors.forename: W B
authors.initials: WB
authors.lastname: Rybka
authors.forename: D
authors.initials: D
authors.lastname: Weinbaum
authors.forename: D R
authors.initials: DR
authors.lastname: Carrigan
authors.forename: K K
authors.initials: KK
authors.lastname: Knox
authors.forename: D F
authors.initials: DF
authors.lastname: Andrews
authors.forename: R K
authors.initials: RK
authors.lastname: Shadduck
mesh_terms: D000328:Adult; D001855:Bone Marrow Diseases / Q000150:complications* / Q000821:virology; D016026:Bone Marrow Transplantation; D006084:Graft Rejection / Q000821:virology*; D006564:Herpesviridae / Q000302:isolation & purification*; D006566:Herpesviridae Infections / Q000150:complications* / Q000821:virology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery*; D008297:Male