Primates: models for red cell transfusion studies--cryopreservation and survival of transfused red cells in primates.
Primates are excellent models for study of blood transfusion in humans. Erythrocytes of chimpanzees, gibbons, baboons, and rhesus monkeys have a half life (T/2) of 14 to 16 days and a life span (T/10) of approximately 50 to 60 days, which is about half of that found in man. Red cells of primates were cryopreserved by freezing using either a droplet method or the low-glycerol rapid-freeze procedure. Thawed cells survive normally when transfused into the same species. Transfusion of incompatible isologous blood in alloimmunized baboons, in the presence of high titer antibodies, showed survival with small volumes to be virtually nil, but with large volumes, a short normal survival period was followed by a "collapse" phenomenon similar to that seen in humans.
Rowe
A W
AW
Laboratory for Experimental Medicine and Surgery in Primates (LEMSIP), New York University Medical Center, New York 10987, USA.
D000255:Adenosine Triphosphate / Q000097:blood; D000818:Animals; D001787:Blood Group Incompatibility; D001793:Blood Preservation; D001803:Blood Transfusion; D002860:Chromium Radioisotopes; D015925:Cryopreservation; D004905:Erythrocyte Aging; D004912:Erythrocytes / Q000378:metabolism*; D000882:Haplorhini / Q000097:blood*; D006801:Humans; D008297:Male; D011188:Potassium / Q000097:blood; D012964:Sodium / Q000097:blood
D002860:Chromium Radioisotopes; D000255:Adenosine Triphosphate; D012964:Sodium; D011188:Potassium