Anti-proliferative effect of 2-methoxyestradiol on cultured smooth muscle cells from rabbit aorta.
The proliferation of cultured smooth muscle cells from rabbit aorta was inhibited markedly by 2-methoxyestradiol, considerably by 2-hydroxyestradiol, and only slightly by 17 beta-estradiol. The effects at doses from 1 to 40 nmol/ml were cytostatic rather than cytocidal. 2-Methoxyestradiol could be useful to suppress excessive proliferation of arterial smooth muscle cells, and thus to prevent the progression of atherosclerosis.
Nishigaki
I
I
Institute of Applied Biochemistry, Gifu, Japan.
Sasaguri
Y
Y
Yagi
K
K
D000077584:2-Methoxyestradiol; D000818:Animals; D001011:Aorta / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured / Q000187:drug effects; D004958:Estradiol / Q000031:analogs & derivatives* / Q000494:pharmacology; D008297:Male; D009131:Muscle, Smooth, Vascular / Q000166:cytology / Q000187:drug effects* / Q000502:physiology; D011817:Rabbits
D004958:Estradiol; D000077584:2-Methoxyestradiol