title: Neuropsychological and neuroanatomical correlates of confabulation.
abstract: In the present exploratory investigation we report nine confabulatory patients of comparable age, education, and general level of intelligence in the acute epoch of recovery after rupture and clipping of ACoA aneurysms. Five of the nine cases had "spontaneous" confabulation, severe anterograde amnesia, markedly poor attentional and executive functions, and denial of illness. These patients all had multiple lesions that involved basal forebrain, ventral frontal lobe, and striatum. The other four patients manifested only "momentary" or "provoked" confabulations. These patients also had severe anterograde amnesia but showed relatively mild deficits in executive functions. These patients had lesions restricted to the basal forebrain except for one who had additional orbital frontal damage. Analysis of these two groups of confabulatory patients suggests that there is a common profile of deficits and anatomic foundation associated with confabulation; "spontaneous" confabulation appears to require extensive, simultaneous disruption of medial basal forebrain and frontal cognitive systems resulting in profound executive and memory deficits, whereas more limited lesions to the basal forebrain or orbital frontal cortex will result in "transient" or "provoked" confabulatory responses and a more restricted profile of cognitive deficits.
authors.affiliation: Neuropsychology Department, New England Sinai Hospital, Stoughton, MA, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Fischer
authors.forename: M P
authors.initials: MP
authors.lastname: Alexander
authors.forename: M
authors.initials: M
authors.lastname: D'Esposito
authors.forename: R
authors.initials: R
authors.lastname: Otto
mesh_terms: D000328:Adult; D000367:Age Factors; D000648:Amnesia, Retrograde / Q000175:diagnosis* / Q000000981:diagnostic imaging; D001288:Attention; D004522:Educational Status; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging*; D006801:Humans; D007360:Intelligence; D008297:Male; D008569:Memory Disorders / Q000175:diagnosis* / Q000000981:diagnostic imaging; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales; D014057:Tomography, X-Ray Computed