The effect of different levels of dietary alpha-linolenic and other fatty acids on mammary gland ductular cell proliferation in female Swiss Webster mice.
In previous work we have shown that changing the fatty acid composition of a constant amount of fat in a modified AIN-76A diet affected the level of ductular cell proliferation in the mammary glands of young virgin female Swiss Webster mice. In particular, linoleic acid concentrations of 5-10% of the total fat in the diet led to variable but appreciably higher levels of proliferation than did higher levels of linoleic acid. In this report it is shown that feeding low levels of the total fat as alpha-linolenic acid (0-5%) resulted in a similar effect. In addition the effects of other fats including menhaden oil, were further investigated.
Lok
E
E
Toxicology Research Division, Health Canada, Ottawa, Ontario.
Jee
P
P
Ratnayake
W M
WM
Scott
F W
FW
Nera
E A
EA
Fernie
S
S
McMullen
E
E
Clayson
D B
DB
D000818:Animals; D002455:Cell Division / Q000187:drug effects; D004032:Diet; D004305:Dose-Response Relationship, Drug; D005227:Fatty Acids / Q000494:pharmacology*; D005260:Female; D008321:Mammary Glands, Animal / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D051379:Mice; D013936:Thymidine / Q000378:metabolism; D014316:Tritium; D017962:alpha-Linolenic Acid / Q000494:pharmacology*
D005227:Fatty Acids; D017962:alpha-Linolenic Acid; D014316:Tritium; D013936:Thymidine