Epidemiology and natural history of hepatitis C infections in liver transplant recipients.
Hepatitis C infection is common in patients undergoing liver transplantation. Few studies have focused on the prevalence and epidemiology of hepatitis C infection among liver transplant recipients since the implementation of donor screening for antibodies against the hepatitis C virus (anti-HCV). Using reverse transcription-polymerase chain reaction (RT-PCR) and genomic sequencing methods, we sought to determine the prevalence, epidemiology, and natural history of hepatitis C infections among 44 consecutive liver transplant patients between January and December 1991. All patients and donors were screened for antibodies against HCV with a first-generation test. Laboratory tests and liver biopsies were routinely done 12 months after transplantation. Serum samples from all organ donors and transplant recipients were analyzed for the presence of HCV-RNA. From four of the six HCV-RNA-positive patients, pre- and post-transplant serum samples were available for sequence analysis. No donor had detectable HCV-RNA. Six of 44 (13.6%) patients had detectable HCV-RNA before and after liver transplantation. Recurrent infection was documented in all who were infected before transplantation and was confirmed by genotype analysis in the four patients who were analyzed. No acquired infections were identified. After transplantation, the HCV-RNA-positive recipients had higher mean alanine aminotransferase (207 +/- 85 U/l vs 37 +/- 7 U/l; p < 0.0001) and were more likely to have chronic hepatitis (50% vs 6%; p < 0.03) than the HCV-RNA-negative recipients.(ABSTRACT TRUNCATED AT 250 WORDS)
Weinstein
J S
JS
Division of Gastroenterology, Mayo Clinic and Foundation, Rochester, MN 55905, USA.
Poterucha
J J
JJ
Zein
N
N
Wiesner
R H
RH
Persing
D H
DH
Rakela
J
J
D001483:Base Sequence; D016174:Hepacivirus / Q000276:immunology* / Q000302:isolation & purification; D006526:Hepatitis C / Q000453:epidemiology* / Q000503:physiopathology / Q000601:surgery; D006801:Humans; D016031:Liver Transplantation; D008403:Mass Screening; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D015995:Prevalence; D012189:Retrospective Studies; D014019:Tissue Donors; D014766:Viremia / Q000453:epidemiology*