title: Up-regulation of calretinin in the supraoptic nucleus of the rat after chronic salt loading.
abstract: We immunocytochemically examined the effect of chronic salt loading on the content of calretinin, a calcium-binding protein, in both the supraoptic nucleus and the magnocellular parts of the hypothalamic paraventricular nucleus. In control rats that were given water for drinking, the supraoptic nucleus contained a cluster of calretinin-stained cells. Drinking 2% sodium chloride solution for 7 days resulted in an increase of the staining intensity of calretinin in cells of the suprasoptic nucleus. In both the control and salt-loaded rats, the magnocellular parts of the paraventricular nucleus were almost devoid of calretinin-labeled cells. It is suggested that expression of calretinin in cells of the supraoptic nucleus is up regulated by chronic salt loading.
authors.affiliation: Department of Anatomy, Fujita Health University School of Medicine, Aichi, Japan.
authors.forename: R
authors.initials: R
authors.lastname: Arai
authors.forename: D M
authors.initials: DM
authors.lastname: Jacobowitz
authors.forename: I
authors.initials: I
authors.lastname: Nagatsu
mesh_terms: D000818:Animals; D064032:Calbindin 2; D004326:Drinking; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D064030:S100 Calcium Binding Protein G / Q000494:pharmacology*; D012492:Salts; D013495:Supraoptic Nucleus; D015854:Up-Regulation
chemical_list: C576512:Calb2 protein, rat; D064032:Calbindin 2; D064030:S100 Calcium Binding Protein G; D012492:Salts