title: Influence of route of administration on progesterone metabolism.
abstract: While inducing similar progesterone levels, the ratio of 5 alpha- and 5 beta-pregnanolone/progesterone plasma concentrations has been dramatically increased after oral as opposed to vaginal administration, in a cross-over study. The known psychotropic effects of 5 alpha- and 5 beta-pregnanolone lead to different indications and precautions for oral and vaginal administration of progesterone.
authors.affiliation: Département d'endocrinologie et Médecine de la Reproduction, Hopital Necker, Paris, France.
authors.forename: B
authors.initials: B
authors.lastname: de Lignieres
authors.forename: L
authors.initials: L
authors.lastname: Dennerstein
authors.forename: T
authors.initials: T
authors.lastname: Backstrom
mesh_terms: D004092:20-alpha-Dihydroprogesterone / Q000097:blood; D000282:Administration, Intravaginal; D000284:Administration, Oral; D018592:Cross-Over Studies; D003900:Desoxycorticosterone / Q000097:blood; D005260:Female; D006801:Humans; D011280:Pregnanolone / Q000097:blood; D011374:Progesterone / Q000008:administration & dosage* / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D004092:20-alpha-Dihydroprogesterone; D003900:Desoxycorticosterone; D011374:Progesterone; D011280:Pregnanolone