Pleurotus fruiting bodies contain the inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin.
In the fruiting bodies of the fungus Pleurotus ostreatus, also called the oyster mushroom, we found a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase-lovastatin. The appearance of the inhibitor during the development of fruiting bodies was followed and lovastatin determined in the vegetative mycelium, in the primordia, as well as in different parts of sporocarps of different sizes. Less lovastatin was found in stripes as compared to pili or in mature stages in the lamellae and basidiospores.
Gunde-Cimerman
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N
National Institute of Chemistry, Laboratory for Biotechnology and Industrial Mycology, Ljubljana, Slovenia.
Cimerman
A
A
D002457:Cell Extracts; D002851:Chromatography, High Pressure Liquid; D006903:Hydroxymethylglutaryl CoA Reductases; D008148:Lovastatin / Q000032:analysis*; D011124:Polyporaceae / Q000737:chemistry* / Q000254:growth & development; D013172:Spores, Fungal / Q000737:chemistry; D014018:Tissue Distribution
D002457:Cell Extracts; D008148:Lovastatin; D006903:Hydroxymethylglutaryl CoA Reductases