title: Striatal neurones displaying substance P (NK1) receptor immunoreactivity in human and non-human primates.
abstract: The striatum of normal human subjects and that of squirrel monkeys (Saimiri sciureus) was found to contain two distinct types of neurones displaying immunoreactivity for substance P (neurokinin-1) receptor (SPR). Large and medium-sized SPR-immunoreactive neurones, both with aspiny dendrites, were fairly uniformly distributed in the striatum of humans and squirrel monkeys. In humans the proportions of large and medium-sized SPR-positive neurones were 57.2% and 42.8% in putamen, compared with 51.9% and 48.1% in caudate nucleus. These findings suggest that substance P exerts its local influence not only on large cholinergic neurones, as commonly believed, but also on a subset of medium-sized interneurones in the striatum of human and non-human primates.
authors.affiliation: Centre de recherche en neurobiologie, Hôpital de l'Enfant-Jésus, Quebec, (QC), Canada.
authors.forename: A
authors.initials: A
authors.lastname: Parent
authors.forename: F
authors.initials: F
authors.lastname: Cicchetti
authors.forename: T G
authors.initials: TG
authors.lastname: Beach
mesh_terms: D000328:Adult; D000818:Animals; D048429:Cell Size; D003342:Corpus Striatum / Q000737:chemistry* / Q000166:cytology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D009474:Neurons / Q000737:chemistry*; D018040:Receptors, Neurokinin-1 / Q000032:analysis*; D012453:Saimiri
chemical_list: D018040:Receptors, Neurokinin-1