title: Xylitol chewing gum and dental caries.
abstract: There is an extensive peer-reviewed literature on xylitol chewing gum as it pertains to effects on tooth decay in human subjects, on human dental plaque reduction, on inhibition of dental plaque acid production, on inhibition of the growth and metabolism of the mutans group of streptococci which are the prime causative agents of tooth decay, on reduction of tooth decay in experimental animals, and on xylitol's reported contribution to the remineralisation of teeth. The literature not only supports the conclusion that xylitol is non-cariogenic but it is now strongly suggestive that xylitol is caries inhibitory, that is, anti-cariogenic in human subjects, and it supplies reasonable mechanistic explanation(s).
authors.affiliation: Department of Oral Diagnosis, University of Connecticut School of Dental Medicine, Farmington.
authors.forename: J M
authors.initials: JM
authors.lastname: Tanzer
mesh_terms: D000818:Animals; D002327:Cariostatic Agents; D002638:Chewing Gum; D003731:Dental Caries / Q000517:prevention & control*; D003773:Dental Plaque / Q000378:metabolism / Q000382:microbiology / Q000517:prevention & control; D006801:Humans; D013295:Streptococcus mutans / Q000378:metabolism; D013549:Sweetening Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D014089:Tooth Remineralization; D014993:Xylitol / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D002327:Cariostatic Agents; D002638:Chewing Gum; D013549:Sweetening Agents; D014993:Xylitol