Inhibition of inflammatory responses by epitaondiol and other marine natural products.
The marine metabolites pacifenol, stypotriol triacetate and epitaondiol were tested for their effects on a number of inflammatory responses. Epitaondiol exhibited a potent topical anti-inflammatory activity related to inhibition of leukocyte accumulation. The other compounds showed a lower potency, similar to that of indomethacin. None of the compounds affected superoxide generation by human neutrophils but pacifenol effectively inhibited the degranulation response. This compound and epitaondiol decreased the release of eicosanoids with a higher potency on the cyclo-oxygenase pathway. Only epitaondiol inhibited human recombinant synovial phospholipase A2 activity in a concentration-dependent manner.
Gil
B
B
Department of Pharmacology, University of Valencia, Spain.
Ferrándiz
M L
ML
Sanz
M J
MJ
Terencio
M C
MC
Ubeda
A
A
Rovirosa
J
J
San-Martin
A
A
Alcaraz
M J
MJ
Payá
M
M
D000818:Animals; D000893:Anti-Inflammatory Agents / Q000494:pharmacology*; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D000001:Calcimycin / Q000494:pharmacology; D003574:Cytochrome c Group / Q000378:metabolism; D004431:Ear, External / Q000187:drug effects; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy; D006801:Humans; D007249:Inflammation / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology; D007975:Leukotriene B4 / Q000378:metabolism; D051379:Mice; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010084:Oxidation-Reduction; D010741:Phospholipases A / Q000378:metabolism; D054467:Phospholipases A2; D012717:Sesquiterpenes / Q000494:pharmacology*; D013256:Steroids; D013268:Stimulation, Chemical; D013481:Superoxides / Q000097:blood; D013729:Terpenes / Q000494:pharmacology*; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity; D013929:Thromboxane B2 / Q000378:metabolism
D000893:Anti-Inflammatory Agents; D000894:Anti-Inflammatory Agents, Non-Steroidal; D003574:Cytochrome c Group; D012717:Sesquiterpenes; D013256:Steroids; D013729:Terpenes; D013481:Superoxides; D007975:Leukotriene B4; C094445:pacifenol; D000001:Calcimycin; D013929:Thromboxane B2; C094447:stypotriol; C094446:epitaondiol; D010741:Phospholipases A; D054467:Phospholipases A2; D013755:Tetradecanoylphorbol Acetate