title: Antithrombotic and antinflammatory drugs for protection of microvascular anastomosis.
abstract: The results of microsurgical procedures in 43 patients who underwent replantation, as well as free tissue transfer were studied. The following scheme of antithrombotic medication was applied postoperatively: a) 330 mg acetylsalicylic acid and 75 mg dipyridamole; b) 440 mL low molecular weight dextran, divided in 2 doses; c) 60000 IU streptokinase and 15000 IU streptodonase; and d) 100 mg diclofenac. 29 of the patients were completely free of complications. Transient vascular spasm was noted in 10 patients and 2 patients developed necrotic lesions distal to the microvascular anastomosis which resulted in two secondary amputations. These results suggest that although antithrombotic treatment can not be seen as a substitute for fine surgical procedures, it still remains powerful tool in the hands of microsurgeons.
authors.affiliation: Orthopaedic Department of the General Hospital of Argos, Greece.
authors.forename: K A
authors.initials: KA
authors.lastname: Vretos
authors.forename: A G
authors.initials: AG
authors.lastname: Tsavissis
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000673:Amputation, Traumatic / Q000601:surgery; D000714:Anastomosis, Surgical; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002648:Child; D005260:Female; D005343:Fibrinolytic Agents / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008833:Microcirculation / Q000187:drug effects; D008866:Microsurgery / Q000379:methods*; D008875:Middle Aged; D012092:Replantation / Q000379:methods; D017695:Soft Tissue Injuries / Q000601:surgery; D014656:Vascular Surgical Procedures / Q000379:methods*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D005343:Fibrinolytic Agents