title: [Liver tumor imaging by thallium-201 chloride with high resolution three-headed SPECT].
abstract: Thallium-201 chloride (Tl) is useful in tumor imaging. The purpose of this study was to evaluate its usefulness in liver tumor imaging with Tl, 99mTc (Tc)-phytate (colloid), and three-headed SPECT. To evaluate the method, we imaged three spherical phantoms with inner/outer diameters of 8/10, 16/20, and 26/30 mm, respectively, in an aqueous solution background of 37 MBq/l Tl and 74 MBq/l Tc. All lesions in the phantoms were highlighted by the subtraction. Clinical materials consisted of 44 patients with 102 lesions: 31/73 with hepatocellular carcinoma (HCC), 8/21 with metastatic tumors (Meta), 2/2 with cholangiocarcinoma (CC), and 3/6 with hemangioma (HG). Tl accumulation in HCC was the highest, followed by Meta, CC and HG in that order. Ring type accumulation was observed in 17/21 Meta lesions. Mean tumor/non-tumor ratios were as follows: HCC (non-therapy) 1.45 +/- 0.33 (mean +/- SD), HCC (post-therapy; transcatheter arterial embolization and percutaneous ethanol injection therapy) 0.47 +/- 0.22, HCC (recurrence) 1.35 +/- 0.52, Meta 1.07 +/- 0.25, CC 0.45 +/- 0.64, HG 0.48 +/- 0.13. Tl, therefore, is useful for liver tumor imaging, and Tc-phytate is essential in discriminating Tl tumor uptake from normal liver accumulation. Image subtraction (Tl-Tc) is helpful in depicting diffuse and small HCC.
authors.affiliation: Department of Radiology, Ehime University, School of Medicine.
authors.forename: T
authors.initials: T
authors.lastname: Takechi
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D006528:Carcinoma, Hepatocellular / Q000000981:diagnostic imaging*; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D008961:Models, Structural; D015609:Organotechnetium Compounds; D010833:Phytic Acid; D013793:Thallium; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D015609:Organotechnetium Compounds; D013794:Thallium Radioisotopes; C026177:technetium phytate; C027549:thallium chloride; D010833:Phytic Acid; D013793:Thallium