title: Pentylenetetrazole kindling impairs long-term memory in rats.
abstract: The effect of pentylenetetrazole (PTZ) kindling on learning and retention in active (shuttle-box) and passive (step-down) avoidance was studied in rats. PTZ kindling did not impair learning and significantly disturbed long-term memory estimated from retention tests, i.e. PTZ kindling induced a retrograde amnesia in the active and passive avoidance situations. The present results support the view that memory deficit is an integral part of epilepsy.
authors.affiliation: Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
authors.forename: M G
authors.initials: MG
authors.lastname: Genkova-Papazova
authors.forename: M B
authors.initials: MB
authors.lastname: Lazarova-Bakarova
mesh_terms: D000648:Amnesia, Retrograde / Q000139:chemically induced; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D007696:Kindling, Neurologic; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
chemical_list: D010433:Pentylenetetrazole