Inhibition of gamma delta T cell recognition by receptors for MHC class I molecules.
NK cells have receptors for MHC class I molecules that inhibit cytotoxicity against target cells. We show that recognition of gamma delta CTL is negatively regulated by receptors for MHC class I molecules. Cytolysis of C1R cells by gamma delta CTL clones was inhibited by the expression of polymorphic HLA class I molecules on target cells and was restored by blocking with anti-HLA class I mAb, suggesting the presence of inhibitory receptors for HLA class I molecules. The receptors for HLA class I molecules on gamma delta T cells were heterogenous. The immune responses to various Ags may be regulated via these inhibitory receptors on T cells and NK cells.
Nakajima
H
H
Department of Tumor Biology, University of Tokyo, Japan.
Tomiyama
H
H
Takiguchi
M
M
D002999:Clone Cells; D003602:Cytotoxicity, Immunologic; D015234:HLA-A Antigens / Q000378:metabolism*; D015235:HLA-B Antigens / Q000378:metabolism*; D006801:Humans; D007108:Immune Tolerance; D007694:Killer Cells, Natural / Q000276:immunology*; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000502:physiology*; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology*
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D016692:Receptors, Antigen, T-Cell, gamma-delta