DMSA chelation during co-exposure to lead: increased locomotor activity in lead-exposed mice but not controls.
We investigated the effect of chelating agent meso-2,3 dimercaptosuccinic acid (DMSA) on indices of "hyperactive" behavior in lead-exposed and control Binghamton Heterogeneous Stock (Het) mice. As expected, 6 weeks of ingestion of 0.5% lead acetate in drinking water reduced immobility in a forced water swim relative to controls. DMSA did not attenuate this behavioral change. In fact, DMSA interacted with lead exposure to increase locomotor activity in the forced water swim. DMSA also apparently excacerbated lead's tendency to reduce immobility. While any generalizations to human populations should be cautioned, these results and others suggest the need for further research.
Stewart
P W
PW
Department of Psychology, State University of New York at Binghamton 13902, USA.
Burright
R G
RG
Donovick
P J
PJ
D000818:Animals; D001143:Arousal / Q000187:drug effects*; D005106:Exploratory Behavior / Q000187:drug effects; D007855:Lead Poisoning / Q000523:psychology*; D008297:Male; D051379:Mice; D009043:Motor Activity / Q000187:drug effects*; D009942:Organometallic Compounds / Q000037:antagonists & inhibitors / Q000633:toxicity*; D004113:Succimer / Q000494:pharmacology*; D013550:Swimming
D009942:Organometallic Compounds; D004113:Succimer; C008261:lead acetate