Somatostatin in physiological concentrations inhibits basal and enhances luteinizing hormone-stimulated progesterone release from human granulosa-luteal cells.
To study the effect of somatostatin on ovarian function, we investigated the action of physiological concentrations of somatostatin (5.0 x 10(-12)-1.0 x 10(-10) M) on the basal and luteinizing hormone (LH)-stimulated progesterone release from cultured human granulosa-luteal cells obtained from in-vitro fertilization patients. Somatostatin exerted a significant and inhibitory effect on basal progesterone release from the granulosa-luteal cells, whereas it was unable to inhibit LH-stimulated progesterone release. Instead, a significant increase in progesterone release was observed after concomitant incubation with LH and somatostatin compared with the untreated controls. We suggest that somatostatin may serve as a regulator of ovarian functions under physiological conditions.
Holst
N
N
Department of Obstetrics and Gynecology, National Hospital, University of Oslo, Norway.
Jacobsen
M B
MB
Haug
E
E
Tanbo
T
T
Abyholm
T
T
D001481:Basal Metabolism; D002478:Cells, Cultured; D004357:Drug Synergism; D005260:Female; D006107:Granulosa Cells / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D008183:Luteal Phase / Q000187:drug effects*; D007986:Luteinizing Hormone / Q000494:pharmacology*; D011374:Progesterone / Q000378:metabolism*; D013004:Somatostatin / Q000494:pharmacology* / Q000502:physiology; D013268:Stimulation, Chemical
D011374:Progesterone; D013004:Somatostatin; D007986:Luteinizing Hormone