title: Bacteremia caused by the Bacteroides fragilis group in patients with hematologic diseases.
abstract: During a 22-year period, 13 patients with hematologic diseases developed bacteremia caused by the Bacteroides fragilis group, with a frequency which remained almost unchanged. Nine patients (69%) had polymicrobial infections. Acute leukemia was the most common underlying disease. The lower intestinal tract (necrotizing enterocolitis and anorectal abscesses) was the most common source of infection. Prior antibiotic therapy was the most frequent host condition before bacteremia, followed by cancer chemotherapy, neutropenia, thrombocytopenia and hypoproteinemia. Septic shock occurred only in seven patients with polymicrobial infections. Six patients, including five with shock, died within a week of onset, while the other seven survived for at least three weeks. Despite its clinical similarity to aerobic gram-negative infection, bacteremia due to the B. fragilis group may well, therefore, be suspected particularly when neutropenic patients who present with lower intestinal symptomatology develop a persistent fever unresponsive to the initial empiric antibiotic therapy.
authors.affiliation: Protected Environment Unit, Kanazawa University School of Medicine.
authors.forename: H
authors.initials: H
authors.lastname: Funada
authors.forename: T
authors.initials: T
authors.lastname: Matsuda
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D016470:Bacteremia / Q000188:drug therapy / Q000209:etiology / Q000382:microbiology*; D001442:Bacteroides Infections; D001441:Bacteroides fragilis; D004761:Enterocolitis, Pseudomembranous / Q000209:etiology; D005260:Female; D006801:Humans; D007769:Lactams; D007938:Leukemia / Q000150:complications*; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications
chemical_list: D000900:Anti-Bacterial Agents; D007769:Lactams