Effect of tetanus toxin on basal and evoked release of 5-hydroxytryptamine and dopamine in rat hippocampus in vivo.
Tetanus toxin is a potent neurotoxin which produces seizures and usually death in mammals. In the present study, we have investigated the effect of tetanus toxin on extracellular basal and evoked release of 5-hydroxytryptamine (5-HT), dopamine (DA) and their metabolites in vivo, 7 days after toxin injection into the hippocampus of rats. Tetanus toxin decreased both basal and evoked release of 5-HT and DA. The 5-HT metabolite 5-hydroxyindoleacetic acid (5-HIAA) was not significantly decreased in the extracellular space. Of the DA metabolites 3,4-dihydroxyphenylacetic acid (DOPAC) concentration was decreased while that of homovanillic acid (HVA) was unchanged. These findings are considered in light of the possible contributory role that a decrease in monoamine concentration in the hippocampus might have in the effects of tetanus toxin.
Britton
P
P
Department of Pharmacology, School of Pharmacy, London, UK.
Whitton
P S
PS
Bowery
N G
NG
D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D004298:Dopamine / Q000378:metabolism*; D006624:Hippocampus / Q000187:drug effects; D008297:Male; D017551:Microdialysis; D011188:Potassium / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012701:Serotonin / Q000378:metabolism*; D013744:Tetanus Toxin / Q000633:toxicity*; D013997:Time Factors
D013744:Tetanus Toxin; D015102:3,4-Dihydroxyphenylacetic Acid; D012701:Serotonin; D011188:Potassium; D004298:Dopamine