Matching for MHC haplotypes results in improved survival following unrelated bone marrow transplantation.
Unrelated bone marrow donor-recipient pairs were assessed retrospectively for matching of the HLA-B, -C region (beta-block) and HLA-DR, DQ region (delta block) of the major histocompatibility complex (MHC) using a new DNA-based method referred to as MHC-block typing. The method utilises non-HLA DNA polymorphisms in the MHC as markers of blocks of ancestral haplotypes. Kaplan-Meier analysis of recipients who were matched at both the beta- and delta-blocks revealed a 6 months survival of 54%. Survival was better than for patients who were matched only by conventional criteria, including SSO-typing for class II.
Tay
G K
GK
Department of Clinical Immunology, Royal Perth Hospital, Australia.
Witt
C S
CS
Christiansen
F T
FT
Charron
D
D
Baker
D
D
Herrmann
R
R
Smith
L K
LK
Diepeveen
D
D
Mallal
S
S
McCluskey
J
J
D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002461:Cell Line, Transformed; D006683:HLA-DQ Antigens / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology; D006402:Hematologic Diseases / Q000401:mortality* / Q000628:therapy; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D016555:Matched-Pair Analysis; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies
D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II