title: Growth of the cranial vault in rabbits with congenital coronal suture synostosis.
abstract: Craniofacial growth data from craniosynostotic children have shown that suture immobilization results in predictable restrictions of cranial vault growth in a direction perpendicular to the affected suture and compensatory growth at sutures perpendicular to the affected one. This study tests these predictions by using rabbits with nonsyndromic congenital coronal suture synostosis. Data were collected from 96 rabbits divided into three groups: 42 unaffected litter mate controls, 33 partially synostosed rabbits, and 21 completely synostosed rabbits. Markers were placed bilaterally on either side of the vault sutures at 1.5 weeks of age. Serial radiographs were taken at 1.5, 6, 12, and 18 weeks of age for assessment of growth at the vault sutures and of various cranial landmarks. Results revealed that completely synostosed animals had significantly (p < .05) shorter cranial vaults, reduced growth at the coronal suture, and increased growth at the sagittal, frontal, and squamosal sutures compared with unaffected rabbits. Results also showed that the calvarial growth observed in this craniosynostotic rabbit model closely reflects predicted compensatory patterns seen in human clinical populations and that this rabbit model is valuable for understanding the pathogeneses and craniofacial growth patterns of humans with premature cranial suture synostosis.
authors.affiliation: Department of Anthropology, University of Pittsburgh, PA 15260, USA.
authors.forename: A M
authors.initials: AM
authors.lastname: Burrows
authors.forename: M P
authors.initials: MP
authors.lastname: Mooney
authors.forename: T D
authors.initials: TD
authors.lastname: Smith
authors.forename: H W
authors.initials: HW
authors.lastname: Losken
authors.forename: M I
authors.initials: MI
authors.lastname: Siegel
mesh_terms: D000222:Adaptation, Physiological; D000367:Age Factors; D000704:Analysis of Variance; D000818:Animals; D002508:Cephalometry; D003393:Cranial Sutures / Q000002:abnormalities / Q000254:growth & development; D003398:Craniosynostoses / Q000503:physiopathology*; D004195:Disease Models, Animal; D008445:Maxillofacial Development; D008576:Meningeal Arteries / Q000002:abnormalities / Q000254:growth & development; D011817:Rabbits; D012016:Reference Values; D012886:Skull / Q000002:abnormalities / Q000254:growth & development*