title: Dy-DTPA-BMA as an indicator of tissue viability in MR imaging. An experimental study in the pig.
abstract: The aim of this study was to investigate whether dysprosium (Dy) induced signal intensity (SI) loss in infarcted tissue in MR imaging. Myocardial infarction was induced in 12 pigs and Dy-DTPA-BMA (1.0 mmol/kg b.w.) was administered i.v. to 6 pigs 4 hours after occlusion and allowed to accumulate in the infarctions for 2 hours. Dy was analysed by inductively coupled plasma atomic emission spectrometry in infarcted and non-ischaemic tissue samples. The remaining 6 pigs, not administered contrast medium, served as controls. The infarctions demonstrated a high SI in the proton density- and T2-weighted sequences in both groups (ex vivo), although the Dy-DTPA-BMA group demonstrated a 3-fold greater concentration of Dy in infarcted compared with non-ischaemic myocardium. The lack of SI loss after Dy accumulation indicates that susceptibility effects are minor or absent in infarcted myocardium.
authors.affiliation: Department of Diagnostic Radiology, University Hospital, Uppsala, Sweden.
authors.forename: S
authors.initials: S
authors.lastname: Nilsson
authors.forename: M
authors.initials: M
authors.lastname: Wikström
authors.forename: H J
authors.initials: HJ
authors.lastname: Martinussen
authors.forename: A
authors.initials: A
authors.lastname: Ericsson
authors.forename: G
authors.initials: G
authors.lastname: Wikström
authors.forename: A
authors.initials: A
authors.lastname: Waldenström
authors.forename: A N
authors.initials: AN
authors.lastname: Oksendal
authors.forename: A
authors.initials: A
authors.lastname: Hemmingsson
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D003287:Contrast Media / Q000493:pharmacokinetics; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D004419:Dysprosium / Q000493:pharmacokinetics; D005260:Female; D008279:Magnetic Resonance Imaging / Q000295:instrumentation / Q000379:methods* / Q000706:statistics & numerical data; D008297:Male; D009203:Myocardial Infarction / Q000097:blood / Q000175:diagnosis; D009206:Myocardium / Q000473:pathology; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D004369:Pentetic Acid / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D013552:Swine; D013997:Time Factors; D014022:Tissue Survival
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; C061756:sprodiamide; D004419:Dysprosium; D004369:Pentetic Acid