title: An adult case of neurohypophyseal ectopy presenting ACTH deficiency and partial GH deficiency.
abstract: A case of ACTH deficiency and partial GH deficiency associated with neurohypophyseal ectopy is described. A 42-year-old woman of short stature was admitted for hypoglycemic coma. The patient had hypocortisolemia, an increase in urinary 17-OHCS after consecutive injections of ACTH-Z, and a low plasma ACTH level which showed no response to corticotropin-releasing factor. This indicated the presence of ACTH deficiency. The plasma GH level showed a blunted response to insulin-induced hypoglycemia, but its response to GRF was preserved. Other hypothalamo-pituitary axes were intact. T1-weighted magnetic resonance imaging demonstrated ectopic neurohypophyseal tissue and a tiny anterior pituitary remnant. ACTH deficiency and partial GH deficiency might have developed as a consequence of pituitary stalk injury and inadequate regeneration of the anterior lobe.
authors.affiliation: Department of Internal Medicine, Kanazawa Red Cross Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takamura
authors.forename: K
authors.initials: K
authors.lastname: Ohsawa
authors.forename: Y
authors.initials: Y
authors.lastname: Nishimura
authors.forename: S
authors.initials: S
authors.lastname: Yamagishi
authors.forename: Y
authors.initials: Y
authors.lastname: Komatsu
authors.forename: A
authors.initials: A
authors.lastname: Iwata
authors.forename: S
authors.initials: S
authors.lastname: Osada
authors.forename: Y
authors.initials: Y
authors.lastname: Nagai
authors.forename: H
authors.initials: H
authors.lastname: Miyakoshi
authors.forename: K
authors.initials: K
authors.lastname: Kobayashi
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000097:blood / Q000172:deficiency*; D000328:Adult; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000172:deficiency*; D006801:Humans; D007018:Hypopituitarism / Q000097:blood / Q000209:etiology*; D010904:Pituitary Gland, Posterior / Q000002:abnormalities*
chemical_list: D000324:Adrenocorticotropic Hormone; D013006:Growth Hormone