MS-444, a new inhibitor of myosin light chain kinase from Micromonospora sp. KY7123.
A novel compound MS-444 was isolated from the culture broth of a bacterial strain KY7123. The strain was identified as Micromonospora sp. from its morphological and cultural characteristics. The compound inhibited the activity of purified smooth muscle myosin light chain kinase with an IC50 value of 10 microM. The production, isolation, physico-chemical properties and biological activities of MS-444 were described in this paper.
Nakanishi
S
S
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd, Japan.
Chiba
S
S
Yano
H
H
Kawamoto
I
I
Matsuda
Y
Y
D000818:Animals; D002645:Chickens; D005285:Fermentation; D005663:Furans / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008847:Micromonospora; D015394:Molecular Structure; D009219:Myosin-Light-Chain Kinase / Q000037:antagonists & inhibitors*; D009284:Naphthols / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology
D005663:Furans; D009284:Naphthols; C096620:5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone; D009219:Myosin-Light-Chain Kinase