title: Matching for MHC haplotypes results in improved survival following unrelated bone marrow transplantation.
abstract: Unrelated bone marrow donor-recipient pairs were assessed retrospectively for matching of the HLA-B, -C region (beta-block) and HLA-DR, DQ region (delta block) of the major histocompatibility complex (MHC) using a new DNA-based method referred to as MHC-block typing. The method utilises non-HLA DNA polymorphisms in the MHC as markers of blocks of ancestral haplotypes. Kaplan-Meier analysis of recipients who were matched at both the beta- and delta-blocks revealed a 6 months survival of 54%. Survival was better than for patients who were matched only by conventional criteria, including SSO-typing for class II.
authors.affiliation: Department of Clinical Immunology, Royal Perth Hospital, Australia.
authors.forename: G K
authors.initials: GK
authors.lastname: Tay
authors.forename: C S
authors.initials: CS
authors.lastname: Witt
authors.forename: F T
authors.initials: FT
authors.lastname: Christiansen
authors.forename: D
authors.initials: D
authors.lastname: Charron
authors.forename: D
authors.initials: D
authors.lastname: Baker
authors.forename: R
authors.initials: R
authors.lastname: Herrmann
authors.forename: L K
authors.initials: LK
authors.lastname: Smith
authors.forename: D
authors.initials: D
authors.lastname: Diepeveen
authors.forename: S
authors.initials: S
authors.lastname: Mallal
authors.forename: J
authors.initials: J
authors.lastname: McCluskey
mesh_terms: D000328:Adult; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002461:Cell Line, Transformed; D006683:HLA-DQ Antigens / Q000276:immunology; D006684:HLA-DR Antigens / Q000276:immunology; D006402:Hematologic Diseases / Q000401:mortality* / Q000628:therapy; D015395:Histocompatibility Antigens Class I / Q000276:immunology*; D000949:Histocompatibility Antigens Class II / Q000276:immunology*; D006650:Histocompatibility Testing / Q000379:methods*; D006801:Humans; D016555:Matched-Pair Analysis; D016133:Polymerase Chain Reaction; D012189:Retrospective Studies
chemical_list: D006683:HLA-DQ Antigens; D006684:HLA-DR Antigens; D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II