[Antibacterial and immunomodulating activity of fucoidan].
The experimental data on the study of the antibacterial and immunomodulating activity of phucoidan, a sulfatated polymer from brown algae (phucan sulfate), were generalized and it was shown that phucoidan was able to markedly inhibit the growth of gramnegative and grampositive organisms and to stimulate immunoreactions of the humoral and cellular types, as well as phagocytosis. The possible use of phucoidan as a drug with associated antibacterial and immunomodulating activity is discussed.
Zapopozhets
T S
TS
Besednova
N N
NN
Loenko
Iu N
IuN
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D000818:Animals; D000890:Anti-Infective Agents / Q000494:pharmacology*; D000917:Antibody Formation / Q000187:drug effects; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D008826:Microbial Sensitivity Tests; D011134:Polysaccharides / Q000494:pharmacology*
D000276:Adjuvants, Immunologic; D000890:Anti-Infective Agents; D011134:Polysaccharides; C007789:fucoidan