title: In-vivo studies on ovarian insulin-like growth factor I concentrations in human preovulatory follicles and human ovarian circulation.
abstract: In some recent hypotheses, the ovary has been indicated as a source of insulin-like growth factor (IGF)-I, with synthesis regulated from local steroidal and non-steroidal substances. We measured IGF-I concentrations in both serum and follicular fluid of women undergoing in-vitro fertilization (IVF) and embryo transfer, in both induced and spontaneous cycles. It was found that serum and follicular IGF-I concentrations were correlated with follicular morphology, oocyte maturity, steroid concentrations and clinical characteristics of IVF cycles. In addition, we measured IGF-I concentrations in both peripheral and ovarian circulation to gain further detailed information on the contribution of the ovary to IGF-I production. The results of our study support the hypothesis that follicular IGF-I is probably derived by diffusion from peripheral circulation and that local production appears unlikely.
authors.affiliation: Institute of Obstetrics and Gynecology, University of Florence, Policlinico Careggi, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Pellegrini
authors.forename: B
authors.initials: B
authors.lastname: Fuzzi
authors.forename: S
authors.initials: S
authors.lastname: Pratesi
authors.forename: M
authors.initials: M
authors.lastname: Mannelli
authors.forename: L
authors.initials: L
authors.lastname: Criscuoli
authors.forename: G
authors.initials: G
authors.lastname: Messeri
authors.forename: G
authors.initials: G
authors.lastname: Forti
mesh_terms: D000328:Adult; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D005498:Follicular Phase / Q000378:metabolism*; D006801:Humans; D007044:Hysterectomy; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008875:Middle Aged; D010053:Ovary / Q000098:blood supply / Q000378:metabolism*; D012039:Regional Blood Flow
chemical_list: D007334:Insulin-Like Growth Factor I