The changing immunology of organ transplantation.
The engrafted organ becomes a chimera as the recipient's leukocytes station themselves in the transplant. Remarkably, the recipient becomes chimeric as well, in a reverse migration involving immune cells from the graft. Interactions between donor and recipient cells are tolerogenic--a process with implications for the goal of graft acceptance with minimal immunosuppression.
Starzl
T E
TE
University of Pittsburgh, USA.
Demetris
A J
AJ
Murase
N
N
Trucco
M
M
Thomson
A W
AW
Rao
A S
AS
D002465:Cell Movement / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods / Q000639:trends*; D016377:Organ Transplantation / Q000379:methods / Q000639:trends*; D018183:Transplantation Chimera / Q000276:immunology*; D014181:Transplantation Immunology / Q000276:immunology*