Radiographic changes and lung function in relation to activity of the glutathione transferases theta and mu among asbestos cement workers.
Experimental data indicate that active oxygen species may be casually involved in the development of asbestos-related disease. Thus, it was hypothesized that individual differences in glutathione transferase activity, which may affect the ability to inactivate molecules formed in relation to oxidative stress, could influence the biological response to asbestos exposure. We could, however, not demonstrate an increased risk for radiographic changes or reduced lung function among asbestos cement workers deficient for glutathione transferase theta (GSTT1), glutathione transferase mu (GSTM1), or having a combined deficiency of enzyme activity.
Jakobsson
K
K
Department of Occupational and Environmental Medicine, University Hospital, Lund, Sweden.
Rannug
A
A
Alexandrie
A K
AK
Warholm
M
M
Rylander
L
L
Hagmar
L
L
D000368:Aged; D001194:Asbestos / Q000009:adverse effects; D001195:Asbestosis / Q000000981:diagnostic imaging* / Q000201:enzymology* / Q000503:physiopathology; D005982:Glutathione Transferase / Q000032:analysis* / Q000235:genetics; D006801:Humans; D007527:Isoenzymes / Q000032:analysis*; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000235:genetics; D011859:Radiography; D012129:Respiratory Function Tests; D012907:Smoking / Q000009:adverse effects
D007527:Isoenzymes; D001194:Asbestos; D005982:Glutathione Transferase