title: Effect of ethyl icosapentate on urinary calcium excretion in calcium oxalate stone formers.
abstract: Buck and co-workers presented the hypothesis that the initiating factor of stone formation triggers the mechanisms for prostaglandin synthesis, resulting in the biochemical abnormalities associated with stone disease. In order to test this hypothesis, we undertook a clinical study with the use of a highly purified preparation of ethyl icosapentate. Ethyl icosapentate (1,800 mg/day) was administered to 57 patients with urinary stones chiefly composed of calcium oxalate for 6 weeks. Urinary calcium in the hypercalciuric patients reduced significantly, but the calcium level in the normocalciuric group did not decrease. Oxalate values did not reduce either in the hypercalciuric patients or in the normocalciuric subjects. No serious side effects were observed.
authors.affiliation: Department of Urology, Teikyo University School of Medicine, Ichihara Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Kotake
authors.forename: K
authors.initials: K
authors.lastname: Nomura
mesh_terms: D000328:Adult; D000368:Aged; D002118:Calcium / Q000652:urine*; D002129:Calcium Oxalate / Q000032:analysis; D015118:Eicosapentaenoic Acid / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008274:Magnesium / Q000652:urine; D008297:Male; D008875:Middle Aged; D011453:Prostaglandins / Q000652:urine; D014508:Urea / Q000652:urine; D014527:Uric Acid / Q000652:urine; D014545:Urinary Calculi / Q000737:chemistry / Q000188:drug therapy* / Q000652:urine
chemical_list: D011453:Prostaglandins; D002129:Calcium Oxalate; D014527:Uric Acid; C035276:eicosapentaenoic acid ethyl ester; D014508:Urea; D015118:Eicosapentaenoic Acid; D008274:Magnesium; D002118:Calcium