title: Indications and results of gentamycin injection into the middle ear of patients with meniére's disease.
abstract: Forty-six cases in whom endolymphatic drainage surgery was performed between 1986 and 1992 were followed up for more than 2 years. The results of numerical values (1985 AAOHNS) revealed complete control of definite spells in 26 cases; substantial control of definite spells in 18 cases; limited control of definite spells in 1 case; and insignificant control of definite spells in 1 case. Hence, endolymphatic drainage surgery for Meniére's disease was effective. There are, however, cases who cannot be operated on because of old age or underlying diseases. In these, we injected gentamycin sulfates mixed with prednisolone through a ventilated tube into the middle ear. The results for gentamycin injection based on numerical values showed complete control of definite spells in 12 cases; and substantial control of definite spells in 7 cases. Our treatment of choice for Meniére's disease is endolymphatic drainage surgery which resulted in 96% control of vertigo. In patients for whom operation has failed, in old patients and in those with hearing impairment more than 50 dB, gentamycin injection into the middle ear has proved to be an effective procedure to control vertigo attacks.
authors.affiliation: Department of Otolaryngology, St. Marianna University School of Medicine, Kawasaki, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: I
authors.initials: I
authors.lastname: Kato
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: K
authors.initials: K
authors.lastname: Yoshino
authors.forename: I
authors.initials: I
authors.lastname: Takeyama
mesh_terms: D000328:Adult; D000368:Aged; D004322:Drainage; D004432:Ear, Middle; D004712:Endolymphatic Sac / Q000601:surgery; D005839:Gentamicins / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D007267:Injections; D008575:Meniere Disease / Q000188:drug therapy* / Q000503:physiopathology / Q000601:surgery; D008875:Middle Aged; D016896:Treatment Outcome; D014432:Tympanic Membrane / Q000187:drug effects
chemical_list: D005839:Gentamicins