title: [Off-label use of lincomycin hydrochloride in 2 horses. Dysbacteriosis and fatal complications due to inadequate symptomatic therapy].
abstract: A lawyer inquired about the possible harmful effects of 'off-label use' of lincomycin in two trotting horses. From information in the relevant dossier it could be concluded that there was no direct indication to use antibiotics. In addition, mistakes were made in the medicinal treatment of horses, namely, the off-label use of lincomycin without prior consultation with the manufacturer, fluid and electrolyte replacement therapy not continued for long enough, and incorrect use of antipyretic analgesics. The intravenous administration of gentamicin to dehydrated patients is permissible only in combination with adequate administration of fluids and electrolytes.
authors.affiliation: Vakgroep Veterinaire Basiswetenschappen, Faculteit Diergeneeskunde van de Universiteit Utrecht.
authors.forename: A S
authors.initials: AS
authors.lastname: van Miert
mesh_terms: D000818:Animals; D004064:Digestive System / Q000382:microbiology*; D017809:Fatal Outcome; D006734:Horse Diseases / Q000139:chemically induced*; D006736:Horses; D008034:Lincomycin / Q000009:adverse effects* / Q000627:therapeutic use; D008297:Male; D012769:Shock / Q000628:therapy / Q000662:veterinary; D014883:Water-Electrolyte Imbalance / Q000139:chemically induced / Q000628:therapy / Q000662:veterinary
chemical_list: D008034:Lincomycin