Overlapping substrate specificities and tissue distribution of cytochrome P450 3A and P-glycoprotein: implications for drug delivery and activity in cancer chemotherapy.
Wacher
V J
VJ
Department of Pharmacy, University of California, San Francisco 94143-0446, USA.
Wu
C Y
CY
Benet
L Z
LZ
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000378:metabolism; D001189:Aryl Hydrocarbon Hydroxylases; D051544:Cytochrome P-450 CYP3A; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D018432:Drug Resistance, Multiple; D004851:Epoxide Hydrolases / Q000378:metabolism; D015870:Gene Expression; D005982:Glutathione Transferase / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy*; D010089:Oxidoreductases, N-Demethylating / Q000378:metabolism*; D013379:Substrate Specificity; D014018:Tissue Distribution
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000970:Antineoplastic Agents; D003577:Cytochrome P-450 Enzyme System; D001189:Aryl Hydrocarbon Hydroxylases; D051544:Cytochrome P-450 CYP3A; D010089:Oxidoreductases, N-Demethylating; D005982:Glutathione Transferase; D004851:Epoxide Hydrolases