title: Disclosure of trauma and immune response to a hepatitis B vaccination program.
abstract: This study investigated whether emotional expression of traumatic experiences influenced the immune response to a hepatitis B vaccination program. Forty medical students who tested negative for hepatitis B antibodies were randomly assigned to write about personal traumatic events or control topics during 4 consecutive daily sessions. The day after completion of the writing, participants were given their first hepatitis B vaccination, with booster injections at 1 and 4 months after the writing. Blood was collected before each vaccination and at a 6-month follow-up. Compared with the control group, participants in the emotional expression group showed significantly higher antibody levels against hepatitis B at the 4 and 6-month follow-up periods. Other immune changes evident immediately after writing were significantly lower numbers of circulating T helper lymphocytes and basophils in the treatment group. The finding that a writing intervention influences immune response provides further support for a link between emotional disclosure and health.
authors.affiliation: Department of Psychiatry and Behavioral Science, University of Auckland Medical School, New Zealand.
authors.forename: K J
authors.initials: KJ
authors.lastname: Petrie
authors.forename: R J
authors.initials: RJ
authors.lastname: Booth
authors.forename: J W
authors.initials: JW
authors.lastname: Pennebaker
authors.forename: K P
authors.initials: KP
authors.lastname: Davison
authors.forename: M G
authors.initials: MG
authors.lastname: Thomas
mesh_terms: D000223:Adaptation, Psychological / Q000502:physiology; D000328:Adult; D000917:Antibody Formation / Q000276:immunology*; D004644:Emotions / Q000502:physiology; D005260:Female; D006509:Hepatitis B / Q000276:immunology*; D006801:Humans; D008016:Life Change Events; D008297:Male; D011598:Psychoneuroimmunology; D012650:Self Disclosure