title: Abdominal aortic aneurysm in the Irish population: a familial screening study.
abstract: A pilot screening programme was undertaken in Ireland to determine the incidence of abdominal aortic aneurysm (AAA) (diameter 3 cm or greater) in the siblings of 120 patients known to have AAA. There were 621 siblings; 270 of them were dead, 32 were over 80 years old and 85 lived outside Ireland, leaving 234 under 80 years of age still living in Ireland who were invited to attend for ultrasonographic screening. Of the 270 siblings who had died, 102 were women and 168 men; eight men (4.8 per cent) had died from ruptured AAA. Only 125 (53.4 percent) of the 234 siblings agreed to participate in the screening programme, 60 brothers from 31 families and 65 sisters from 35 families. Fifteen (12.0 per cent) of the 125 siblings had an AAA (median size 4.2 (range 3.1-6.8) cm), 13 (22 per cent) of the 60 male siblings and two (3 per cent) of the 65 female siblings. The prevalence of AAA among siblings was not affected by the age or sex of the patient with aneurysm. Seven of the 14 male siblings with hypertension had an AAA, compared with only six of the 46 who were normotensive (P = 0.01). The high incidence of AAA in brothers of affected patients highlights the need to counsel this group on their risk of aneurysm. The relatively low participation rate by siblings in this screening programme indicates that a hospital-based unit is unlikely to be effective in recruiting all patient siblings at risk from an AAA.
authors.affiliation: Department of Surgery, Royal College of Surgeons in Ireland, Beaumont Hospital, Dublin.
authors.forename: P
authors.initials: P
authors.lastname: Fitzgerald
authors.forename: D
authors.initials: D
authors.lastname: Ramsbottom
authors.forename: P
authors.initials: P
authors.lastname: Burke
authors.forename: P
authors.initials: P
authors.lastname: Grace
authors.forename: O
authors.initials: O
authors.lastname: McAnena
authors.forename: D T
authors.initials: DT
authors.lastname: Croke
authors.forename: P
authors.initials: P
authors.lastname: Collins
authors.forename: A
authors.initials: A
authors.lastname: Johnson
authors.forename: D
authors.initials: D
authors.lastname: Bouchier-Hayes
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D017544:Aortic Aneurysm, Abdominal / Q000453:epidemiology* / Q000235:genetics; D005190:Family; D005260:Female; D006801:Humans; D015994:Incidence; D007494:Ireland / Q000453:epidemiology; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D010375:Pedigree; D010865:Pilot Projects; D012307:Risk Factors