[Effect of scopolamine on morphine levels in serum and urine in rats].
Free morphine and conjugated morphine were determined by radioimmunoassay. Excretion of conjugated morphines in urine was increased significantly by treatment with scopolamine in a dose-related manner in morphine-dependent Sprague-Dawley rats (n = 8). Conjugated morphine in serum was increased by administration of scopolamine greater than that of controls at 2h, and both free and conjugated morphine in serum were enhanced at 24h after last injection of morphine in morphine-dependent rats (n = 6). After use of scopolamine (0.5mg/kg, bid, ip) for 3d the rats (n = 6) received single injection of morphine (10mg/kg, sc), the levels of free morphine were increased greater than those of controls at 2 and 10h. The data showed that scopolamine may not only induced the metabolism of morphine in liver, but also facilitated subcutaneous absorption of morphine, which result in enhancing the excretion of morphine.
Zhou
W
W
Ningbo Institute of Microcirculation.
Zhu
B
B
Chen
Q
Q
D000818:Animals; D008297:Male; D009020:Morphine / Q000378:metabolism*; D009021:Morphine Dependence / Q000188:drug therapy / Q000378:metabolism; D011863:Radioimmunoassay; D051381:Rats; D017207:Rats, Sprague-Dawley; D012601:Scopolamine / Q000494:pharmacology*
D009020:Morphine; D012601:Scopolamine