title: [Refractory peptic ulcer: the pathogenic mechanisms].
abstract: The vast majority of peptic ulcers heal after treatment with either H2 receptor antagonists or omeprazole at standard doses. However, it is also recognized that a 5-10% of peptic ulcers will not heal. The possibility of identifying the factors associated with refractory ulcers would have important repercussions. Several retrospective and prospective studies have pointed out a number of clinical, environmental or intrinsic factors. In recent years 2 factors have emerged as the main cause of peptic ulcer. Helicobacter pylori infection and NSAID use, and these two factors might be involved in the pathogenesis of refractory ulcer.
authors.affiliation: Servicio de Aparato Digestivo, Hospital Clínico Universitario, Zaragoza.
authors.forename: B
authors.initials: B
authors.lastname: Remacha Tomey
authors.forename: A
authors.initials: A
authors.lastname: Lanas Arbeloa
authors.forename: R
authors.initials: R
authors.lastname: Sainz Samitier
mesh_terms: D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects; D002908:Chronic Disease; D005744:Gastric Acid / Q000378:metabolism; D016481:Helicobacter Infections / Q000150:complications; D016480:Helicobacter pylori; D006801:Humans; D010437:Peptic Ulcer / Q000209:etiology*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal