title: Taxuspine D, a new taxane diterpene from Taxus cuspidata with potent inhibitory activity against Ca(2+)-induced depolymerization of microtubules.
abstract: A new taxane diterpenoid, taxuspine D (1), possessing an enolacetate moiety, has been isolated from stems of the Japanese yew Taxus cuspidata Sieb. et Zucc., and the structure elucidated on the basis of spectroscopic data. Taxuspine D (1) markedly inhibited Ca(2+)-induced depolymerization of microtubules.
authors.affiliation: Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
authors.forename: J
authors.initials: J
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Hosoyama
authors.forename: H
authors.initials: H
authors.lastname: Shigemori
authors.forename: Y
authors.initials: Y
authors.lastname: Koiso
authors.forename: S
authors.initials: S
authors.lastname: Iwasaki
mesh_terms: D002118:Calcium / Q000494:pharmacology; D008870:Microtubules / Q000187:drug effects; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*; D043823:Taxoids; D014404:Tubulin / Q000378:metabolism
chemical_list: D043823:Taxoids; D014404:Tubulin; C094551:taxuspine D; D017239:Paclitaxel; D002118:Calcium