title: Prognostic significance of nucleolar organizer regions in recurrent pleomorphic adenomas of salivary glands.
abstract: Pleomorphic adenoma (PA) is the commonest tumor of salivary glands. It is considered a benign tumor which may recur and rarely metastatize. There are no reliable histological criteria for predicting recurrences of PA. In this paper, Ag-NOR expression, evaluated by means a computer assisted image analysis system, has been tested on 11 cases of PA, their recurrences, 10 non recurrent PA and 5 cases of carcinoma ex PA. Mean AgNOR count, mean AgNOR area and mean AgNOR area/particle were determined in each group. AgNOR count and area did not show any significant differences between recurrent and non recurrent PA. On the contrary, AgNOR area/particle seems to be a useful tool in predicting the clinical behaviour of this lesion.
authors.affiliation: Dipartimento di Scienze Morfologiche e Medico Legali, Università di Modena, Italia.
authors.forename: M
authors.initials: M
authors.lastname: Criscuolo
authors.forename: M
authors.initials: M
authors.lastname: Migaldi
authors.forename: G
authors.initials: G
authors.lastname: Collina
authors.forename: A M
authors.initials: AM
authors.lastname: Cesinaro
authors.forename: R
authors.initials: R
authors.lastname: Galetti
authors.forename: F
authors.initials: F
authors.lastname: Lo Bianco
authors.forename: G P
authors.initials: GP
authors.lastname: Trentini
mesh_terms: D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009697:Nucleolus Organizer Region / Q000473:pathology*; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000473:pathology*