The effects of mammillary body lesions on delayed matching and delayed non-matching to place tasks in the mice.
This study was designed to investigate the effects of different recognition procedures on memory performance in Balb/c mice. To this end, mice were submitted to spontaneous or contingently reinforced delayed non-matching (DNMTP) and delayed matching (DMTP) to place tasks in a T-maze. Results indicate that mammillary bodies (MM)-lesioned subjects are significantly impaired in the DNMTP tasks at the long (6 h) but not the short (5 min) delays; in contrast, they did not exhibit deficits in the DMTP task, whatever the delay considered. We stress the importance of task difficulty as a major factor explaining the different effects of the lesion in the two tasks.
Béracochéa
D J
DJ
Laboratoire de Neurosciences Cognitives et Comportementales, URA CNRS 339, Université de Bordeaux I, Talence, France.
Jaffard
R
R
D000818:Animals; D003216:Conditioning, Operant / Q000502:physiology*; D005502:Food; D007051:Ibotenic Acid / Q000633:toxicity; D008297:Male; D008326:Mammillary Bodies / Q000033:anatomy & histology / Q000502:physiology*; D008568:Memory / Q000502:physiology; D051379:Mice; D008807:Mice, Inbred BALB C; D012054:Reinforcement, Psychology; D012201:Reward; D013028:Space Perception / Q000502:physiology*
D007051:Ibotenic Acid