title: Association between proliferative verrucous leukoplakia and infection with human papillomavirus type 16.
abstract: Proliferative verrucous leukoplakia (PVL) is a recently described clinical entity characterized by multifocal oral lesions that frequently progress to oral cancer despite abstinence from tobacco use by most patients. To determine if this condition is associated with human papillomavirus (HPV), a polymerase chain reaction (PCR) for HPV DNA was performed on 9 lesions from 7 patients with PVL, histologically diagnosed with focal keratosis (1), papilloma (1), epithelial dysplasia (5) and squamous cell cancer (2). Eight (89%) were HPV positive, 7 for HPV 16. For comparison, we studied 55 non-PVL-associated oral specimens, including 24 oral squamous cell cancers. Of the cancers, 8 (33%) were HPV positive, 4 for HPV 16. These data suggest that HPV 16 infection may play an important role in the pathogenesis of PVL-associated oral dysplasia and possibly cancer, but is found in only a small proportion of the more common, non-PVL associated-oral lesions.
authors.affiliation: Department of Stomatology, School of Dentistry, University of California, San Francisco 94143, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Palefsky
authors.forename: S
authors.initials: S
authors.lastname: Silverman
authors.forename: M
authors.initials: M
authors.lastname: Abdel-Salaam
authors.forename: T E
authors.initials: TE
authors.lastname: Daniels
authors.forename: J S
authors.initials: JS
authors.lastname: Greenspan
mesh_terms: D000368:Aged; D015139:Blotting, Southern; D002294:Carcinoma, Squamous Cell / Q000821:virology*; D015344:DNA Probes, HPV; D005260:Female; D006801:Humans; D007972:Leukoplakia, Oral / Q000821:virology*; D008297:Male; D008875:Middle Aged; D009062:Mouth Neoplasms / Q000821:virology*; D010212:Papilloma / Q000821:virology; D027383:Papillomaviridae / Q000145:classification / Q000302:isolation & purification*; D030361:Papillomavirus Infections / Q000175:diagnosis*; D016133:Polymerase Chain Reaction; D012703:Serotyping / Q000379:methods; D014412:Tumor Virus Infections / Q000175:diagnosis*; D014860:Warts / Q000821:virology
chemical_list: D015344:DNA Probes, HPV