Synthesis, characterization and antibacterial activity of novel Fe(III), Co(II), and Zn(II) complexes with norfloxacin.
Three novel complexes of norfloxacin (abbreviated as NFL), [M(NFL)2(H2O)2]Cl3.6H2O, (M = Fe, Co), and [Zn(NFL)2]Cl2.7H2O, have been prepared. The compounds were characterized by IR, UV-Vis, NMR spectra, molar conductivity, and elemental analyses. In all of the complexes, the ligand NFL was coordinated through two carboxyl oxygen atoms. Octahedral and tetrahegon geometries have been proposed for Fe(III)-, Co(II)-complexes and Zn(II)-complex, respectively. In vitro test of susceptibility of Fe(III)- and Zn(II)-complexes showed stronger activity than that of norfloxacin against G(-) E.Coli and Bacillus dysenteriae bacteria.
Gao
F
F
Institute of Molecular Science, Shanxi University, Taiyuan, China.
Yang
P
P
Xie
J
J
Wang
H
H
D000890:Anti-Infective Agents / Q000737:chemistry*; D001407:Bacillus / Q000187:drug effects; D003300:Copper / Q000737:chemistry*; D004926:Escherichia coli / Q000187:drug effects; D005290:Ferric Compounds / Q000737:chemistry*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009643:Norfloxacin / Q000737:chemistry*; D013053:Spectrophotometry; D013211:Staphylococcus aureus / Q000187:drug effects; D013329:Structure-Activity Relationship; D015032:Zinc / Q000737:chemistry*
D000890:Anti-Infective Agents; D005290:Ferric Compounds; D003300:Copper; D015032:Zinc; D009643:Norfloxacin