An approach to efficacy screening of mouthrinses: studies on a group of French products (I). Staining and antimicrobial properties in vitro.
There is a large and increasing number of oral hygiene products available to the general public. As such, it is difficult to demonstrate efficacy for all in long-term home-use studies. The aim of this project was to determine whether screening studies could position the activity and efficacy of a number of antiseptic mouthrinses, available in France, by comparison with an established product. This study reports the experiments in vitro. The products under test were, 4 containing chlorhexidine (Eludril, Hibident, Parodex and Prexidine) with Hibident considered the positive control, one containing cetylpyridinium chloride (Alodont) and one containing hexetidine (Hextril). The 1st study determined the antibacterial profile of the chlorhexidine products against a panel of oral bacteria using an agar dilution method. The 2nd study recorded, by optical density, the propensity of all products to induce tea staining on clear acrylic specimens. The maximum inhibitory dilution (MID) of the chlorhexidine products against the test organisms, once adjusted for initial concentration differences, were essentially similar. One exception was Eludril which had an increased MID against Capnocytophaga sputigena, an organism normally less sensitive to chlorhexidine. Hibident and Prexidine produced expected levels of tea staining; that produced by Parodex was lower than the expected. Staining by Eludril was little different than water controls suggesting markedly reduced availability of chlorhexidine in this product.(ABSTRACT TRUNCATED AT 250 WORDS)
Addy
M
M
Department of Oral and Dental Science, University of Bristol, UK.
Wade
W
W
D000180:Acrylic Resins / Q000737:chemistry; D000188:Actinobacillus / Q000187:drug effects; D000891:Anti-Infective Agents, Local / Q000737:chemistry / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D001438:Bacteroidaceae / Q000187:drug effects; D002206:Capnocytophaga / Q000187:drug effects; D002594:Cetylpyridinium / Q000737:chemistry / Q000494:pharmacology; D002710:Chlorhexidine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D004396:Coloring Agents / Q000737:chemistry / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005602:France; D006590:Hexetidine / Q000737:chemistry / Q000494:pharmacology; D009067:Mouthwashes / Q000737:chemistry / Q000494:pharmacology*; D010462:Peptostreptococcus / Q000187:drug effects; D013291:Streptococcus / Q000187:drug effects; D013662:Tea
D000180:Acrylic Resins; D000891:Anti-Infective Agents, Local; D004396:Coloring Agents; D009067:Mouthwashes; D013662:Tea; D006590:Hexetidine; D002594:Cetylpyridinium; C010882:chlorhexidine gluconate; D002710:Chlorhexidine