title: [The role of urinary peptide hydrolase in the laboratory diagnosis of urological diseases].
abstract: The authors determined activity of leucine arylamidase (LA) or microsomal aminopeptidase locating in tubular cell microsomes and as a specific enzyme indicating parenchymal damage in the urine of 28 healthy subjects and 187 patients with nephroliths (103), renal injury (13 contusions, 11 rupture) before and after extracorporeal lithotripsy. Changes in LA were followed up spectrophotometrically. LA levels in healthy controls, nephrolithiasis patients free of pyelonephritis or with it in remission were similar, elevated in latent course and significantly elevated in complicated by inflammation nephrolithiasis, renal injury and in patients with associated pyelonephritis after lithotripsy. The highest LA activity was recorded in patients with renal injury and after lithotripsy with latent or active inflammation before lithotripsy. LA urinary content may serve indication of inflammation in the kidneys, parenchymal involvement. It is a helpful adjuvant diagnostic method in urology.
authors.forename: V N
authors.initials: VN
authors.lastname: Stepanov
authors.forename: V M
authors.initials: VM
authors.lastname: Perel'man
authors.forename: Z A
authors.initials: ZA
authors.lastname: Kadyrov
mesh_terms: D004796:Clinical Enzyme Tests; D003288:Contusions / Q000175:diagnosis; D006801:Humans; D007668:Kidney / Q000293:injuries; D007669:Kidney Calculi / Q000175:diagnosis / Q000628:therapy; D007931:Leucyl Aminopeptidase / Q000652:urine; D008096:Lithotripsy; D010447:Peptide Hydrolases / Q000652:urine*; D012421:Rupture; D013053:Spectrophotometry; D014570:Urologic Diseases / Q000175:diagnosis*
chemical_list: D010447:Peptide Hydrolases; D007931:Leucyl Aminopeptidase