[Therapeutic immunoadsorption in Goodpasture disease].
The extraction of circulating antiglomerular basement membrane (GBM) antibodies by plasmapheresis (PP) has allowed the prognosis of Goodpasture's disease to markedly improve. Immunoabsorption (IA) may improve the results of PP upon allowing more effective immunoglobulin extraction. Two patients with Goodpasture disease were treated with IA. A rapid decrease was observed in the serum levels of anti GBM antibodies and improvement in respiratory failure. In one of the patients this regimen was administered following the observation of a lack of clinical response of pulmonary hemorrhage in three PP sessions (9 liters of treated plasma). In this patient, the IA processed 39 liters of plasma and the method was found to be equally effective on reinstatement (29 liters) on the occasion of a relapse in the pulmonary symptoms presented at three weeks after the first treatment. Both cases showed renal involvement. In one case this was incipient and the treatment was associated with non progression of the kidney disease, normalization of the urine sediment and preservation of renal function. In the second case treatment was initiated at an advanced disease state with no changes in dialysis needs. Immunoadsorption has shown to be effective in the treatment of pulmonary hemorrhage in Goodpasture's disease. Onset of treatment at an early stage of the kidney disease may avoid progression to renal failure.
Moreso
F
F
Servicio de Nefrología, Ciudad Sanitaria y Universitaria de Vellvitge, L'Hospitalet de Llobregat, Barcelona.
Poveda
R
R
Gil-Vernet
S
S
Carreras
L
L
García-Osuna
R
R
Griñó
J M
JM
Alsina
J
J
D000328:Adult; D019867:Anti-Glomerular Basement Membrane Disease / Q000276:immunology* / Q000628:therapy; D000906:Antibodies / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology; D006470:Hemorrhage / Q000276:immunology / Q000628:therapy; D006801:Humans; D007163:Immunosorbent Techniques; D007164:Immunosorbents / Q000627:therapeutic use; D008297:Male; D010956:Plasmapheresis; D011379:Prognosis; D051437:Renal Insufficiency / Q000517:prevention & control
D000906:Antibodies; D007164:Immunosorbents