Anti-inflammatory and hepatoprotective effects of Solanum alatum.
Solanum alatum aqueous extract was investigated on carrageenin-induced edema and on CCl4-induced liver injury. The extract (100 or 200 mg/kg body weight) exhibited both anti-inflammatory and hepatoprotective activities. The effects were more prominent at the dose of 200 mg/kg. Histological changes such as necrosis, fatty changes, ballooning degeneration, and inflammatory infiltration of lymphocytes and Kupffer cells around the central veins were concurrently improved by treatment with the S. alatum aqueous extract.
Lin
C C
CC
School of Pharmacy, Kaohsiung Medical College, Taiwan.
Lin
W C
WC
Yang
S R
SR
Shieh
D E
DE
D000410:Alanine Transaminase / Q000187:drug effects; D000818:Animals; D001219:Aspartate Aminotransferases / Q000187:drug effects; D002251:Carbon Tetrachloride / Q000494:pharmacology; D002351:Carrageenan / Q000494:pharmacology; D056486:Chemical and Drug Induced Liver Injury; D004487:Edema / Q000139:chemically induced; D008099:Liver / Q000187:drug effects*; D008297:Male; D008516:Medicine, Chinese Traditional; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D010936:Plant Extracts; D002351:Carrageenan; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase