title: Pleomorphic hamartoma of the subcutis: a lesion with possible myogenous and neural lineages.
abstract: The authors report an example of an unusual subcuticular spindle cell tumor with histologic features which were most like those of "pleomorphic fibroma." However, the tumor cells exhibited bifid differentiation immunohistologically, with conjoint reactivity for vimentin, S-100 protein, Leu-7 antigen (CD57), myelin basic protein, and desmin. A hamartomatous origin was favored for this lesion, given its overall morphologic features, circumscription, and apparently heterogeneous cellular lineages. Although speculative, it is thought that this unusual cutaneous mass may represent a subcuticular analogue of the benign Triton tumor (neuromuscular choristoma) of deep soft tissues.
authors.affiliation: Lauren V. Ackeman Laboratory of Surgical Pathology, Barnes Hospital, Washington University Medical Center, St. Louis, MO 63110, USA.
authors.forename: P K
authors.initials: PK
authors.lastname: Shitabata
authors.forename: J H
authors.initials: JH
authors.lastname: Ritter
authors.forename: J F
authors.initials: JF
authors.lastname: Fitzgibbon
authors.forename: L P
authors.initials: LP
authors.lastname: Dehner
authors.forename: M R
authors.initials: MR
authors.lastname: Wick
mesh_terms: D002454:Cell Differentiation; D003937:Diagnosis, Differential; D005350:Fibroma / Q000473:pathology; D006222:Hamartoma / Q000473:pathology*; D006801:Humans; D008067:Lipoma / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000294:innervation / Q000473:pathology*; D012871:Skin Diseases / Q000473:pathology*