[The effect of membrane-stabilizing and antioxidant preparations on the lipid peroxidation processes in cerebral stroke].
Changes in the concentration of the lipid peroxidation products in the blood of 152 patients in stroke were studied. 18 patients with LPO processes activation received supplementary treatment with antioxidant preparation (tocopheroli acetas, ascorbic acid, pyridoxalphosphate, glutaminic acid), which lowered significantly the blood content of LPO products; in 12 patients with reduced concentration of LPO products treatments with membrane-stabilizing preparations (lipostabyl, sodium hydroxybutyrate, ascorbic acid, unithiol) were administered, and restoration of LPO processes was established to have occurred. With the purpose of improving methods and assessment of the cerebral insult treatment efficacy, it is recommended that specific features of changes in the concentration of LPO products be used.
Skochiĭ
P H
PH
Korol'
H M
HM
Tymochko
M F
MF
Fedoryshyn
L V
LV
D000208:Acute Disease; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000975:Antioxidants / Q000627:therapeutic use*; D002545:Brain Ischemia / Q000097:blood / Q000188:drug therapy; D002543:Cerebral Hemorrhage / Q000097:blood / Q000188:drug therapy; D002561:Cerebrovascular Disorders / Q000097:blood / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged
D000975:Antioxidants; D008315:Malondialdehyde