Developmental toxicity evaluation of mono-n-butyl phthalate in rats.
Mono-n-butyl phthalate (MBuP) was evaluated for developmental toxicity in Wistar rats. Rats were given MBuP by gastric intubation at 0, 250, 500 or 625 mg/kg on days 7-15 of pregnancy. Significant decreases in the maternal body weight gains and food consumption during pregnancy were found at 500 and 625 mg/kg. Significant increase in the incidence of postimplantation loss per litter and decreases in the number of live fetuses per litter and fetal weight were also detected at 500 mg/kg and above. The incidence of fetuses with malformations in the 500 and 625 mg/kg groups was higher than that in the control group. Cleft palate, deformity of the vertebral column and dilatation of the renal pelvis were frequently observed.
Ema
M
M
National Institute of Health Sciences, Osaka Branch, Japan.
Kurosaka
R
R
Amano
H
H
Ogawa
Y
Y
D000014:Abnormalities, Drug-Induced; D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D005314:Embryonic and Fetal Development / Q000187:drug effects*; D005260:Female; D005327:Fetal Resorption / Q000139:chemically induced; D008297:Male; D008431:Maternal-Fetal Exchange; D010795:Phthalic Acids / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D017208:Rats, Wistar; D013723:Teratogens / Q000633:toxicity*
D010795:Phthalic Acids; D013723:Teratogens; C028577:monobutyl phthalate