title: Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK.
abstract: We have mapped the gene encoding the murine RYK growth factor receptor protein tyrosine kinase by genetic linkage analysis with recombinant inbred strains of mouse. Two distinct Ryk loci (Ryk-1 and Ryk-2) were identified. Ryk-1 mapped to Chromosome (Chr) 9, whereas Ryk-2 mapped to Chr 12. A similar arrangement of RYK-related loci was previously determined in the human. Synteny has already been established between murine Chr 9 in the region of Ryk-1, and human chromosome 3q11-12, the location of the human RYK-1 gene. However, the Ryk-2/RYK-2 loci on murine Chr 12 and human Chr 17p13.3 define a new region of synteny.
authors.affiliation: Walter and Eliza Hall Institute of Medical Research, Royal Melbourne Hospital, Parkville, Victoria, Australia.
authors.forename: N M
authors.initials: NM
authors.lastname: Gough
authors.forename: S
authors.initials: S
authors.lastname: Rakar
authors.forename: C M
authors.initials: CM
authors.lastname: Hovens
authors.forename: A
authors.initials: A
authors.lastname: Wilks
mesh_terms: D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D002875:Chromosomes; D008040:Genetic Linkage; D051379:Mice; D008815:Mice, Inbred Strains / Q000235:genetics*; D012150:Polymorphism, Restriction Fragment Length; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D011956:Receptors, Cell Surface / Q000235:genetics*
chemical_list: D011956:Receptors, Cell Surface; C080836:RYK protein, human; D020794:Receptor Protein-Tyrosine Kinases