title: Prevalence and standardized incidence rates of preclinical cervical pathology among 1,061 women sterilized with transcervical quinacrine hydrochloride pellets.
abstract: OBJECTIVE
  To determine whether the incidence of in situ cervical carcinoma was increased among a cohort of women who received transcervical insertions of quinacrine hydrochloride pellets into the uterine cavity as a method of nonsurgical sterilization.
  
  
  METHODS
  Retrospective review of Papanicolaou (Pap) test results, comparing incidence of high-grade lesions among quinacrine acceptors with a comparison population.
  
  
  METHODS
  Outpatient clinics, Santiago, Chile.
  
  
  METHODS
  Women attending a family planning clinic (quinacrine acceptors) and a comparison population from another area of Santiago.
  
  
  METHODS
  Incidence of in situ cervical carcinoma.
  
  
  RESULTS
  During 3,668 woman-years of follow-up, 8 women in the quinacrine group were found to have in situ carcinomas for an age-adjusted rate of 2.62 per 1,000 woman-years. The incidence in a comparison population was 1.62 per 1,000 woman-years, but the difference was not statistically different.
  
  
  CONCLUSIONS
  The age-standardized incidence of in situ carcinoma among the quinacrine sterilized women was not significantly different from the rate in a comparison population of women in Santiago. However, the study has a number of limitations.
authors.affiliation: Cytopathology and Cancer Control Service, Faculty of Medicine, University of Chile, Santiago.
authors.forename: A
authors.initials: A
authors.lastname: Dabancens
authors.forename: D C
authors.initials: DC
authors.lastname: Sokal
authors.forename: M
authors.initials: M
authors.lastname: Pruyas
authors.forename: M
authors.initials: M
authors.lastname: Rivera
authors.forename: J
authors.initials: J
authors.lastname: Zipper
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002278:Carcinoma in Situ / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D008875:Middle Aged; D015995:Prevalence; D011796:Quinacrine / Q000009:adverse effects*; D012189:Retrospective Studies; D013245:Sterilization, Reproductive / Q000009:adverse effects*; D002583:Uterine Cervical Neoplasms / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D011796:Quinacrine