Synaptic terminals wrapped in the somatic cytoplasm of pigmented neurons in the human locus ceruleus.
We examined the locus ceruleus (LC) of 59 autopsied individuals whose ages at death ranged from 5 to 108 years. Immunocytochemistry with synaptic vesicle-specific 38-kDa protein (SVP) revealed that clusters of SVP-like immunoreactive coarse granules were present in the somatic cytoplasm of some pigmented neurons in all individuals examined. These SVP-like immunoreactive granules were confirmed electron microscopically to be contained in synaptic terminals which were wrapped in the somatic cytoplasm of pigmented LC neurons.
Iwanaga
K
K
Department of Pathology, Niigata University, Japan.
Takahashi
H
H
Yamada
M
M
Ikuta
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001344:Autopsy; D002648:Child; D002675:Child, Preschool; D003593:Cytoplasm / Q000648:ultrastructure*; D006801:Humans; D007150:Immunohistochemistry; D008125:Locus Coeruleus / Q000166:cytology* / Q000648:ultrastructure; D008297:Male; D016253:Microscopy, Immunoelectron; D008875:Middle Aged; D009419:Nerve Tissue Proteins / Q000032:analysis; D009474:Neurons / Q000648:ultrastructure*; D010858:Pigmentation; D017729:Presynaptic Terminals / Q000648:ultrastructure*; D013572:Synaptic Vesicles / Q000737:chemistry
D009419:Nerve Tissue Proteins; C489782:SVP-38 protein, human