title: Signal transduction through the conserved motifs of the high affinity IgE receptor Fc epsilon RI.
abstract: The high affinity receptor for IgE, Fc epsilon RI, possesses three ARAMs, one in the beta chain (ARAM-beta) and one in each member of the dimer of gamma chains (ARAM-gamma). These two types of ARAM endow the chains in which they are located with distinct properties. The ARAM-containing C-terminal tail of beta binds Lyn, a Src family tyrosine kinase which regulates the phosphorylation of beta, gamma and other substrates including Syk. The tyrosine phosphorylated ARAM-containing C-terminal tail of gamma binds Syk which, when activated, controls later signals such as the rise in intracellular calcium. Therefore, the two ARAM-containing chains of Fc epsilon RI cooperate to realize the full signaling capacity of the receptor.
authors.affiliation: Molecular Allergy and Immunology Section, NIAID, NIH, Rockville, MD 20852, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Jouvin
authors.forename: R P
authors.initials: RP
authors.lastname: Numerof
authors.forename: J P
authors.initials: JP
authors.lastname: Kinet
mesh_terms: D000595:Amino Acid Sequence; D017124:Conserved Sequence / Q000276:immunology*; D018448:Models, Immunological; D008969:Molecular Sequence Data; D010744:Phosphoric Monoester Hydrolases / Q000276:immunology / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000276:immunology / Q000378:metabolism; D011940:Receptor Aggregation / Q000276:immunology; D017455:Receptors, IgE / Q000235:genetics* / Q000276:immunology; D015398:Signal Transduction / Q000276:immunology*
chemical_list: D017455:Receptors, IgE; D011505:Protein-Tyrosine Kinases; D010744:Phosphoric Monoester Hydrolases