Late graft failure due to dual bone marrow infection with variants A and B of human herpesvirus-6.
Hematopoietic effects of human Herpesvirus-6 (HHV-6) infection following bone marrow transplantation (BMT) include delayed engraftment and early myelosuppression. Variant A has not been isolated after BMT. A case of graft failure is reported following an HLA-identical BMT for chronic myelogenous leukemia (CML) in chronic phase. Evaluation of bone marrow during the period of graft failure revealed variants A and B of HHV-6 by culture, immunofluorescence, polymerase chain reaction (PCR), and immunohistochemistry. Evidence for other cases of graft failure, including cytomegalovirus (CMV), could not be found. A hypothesis is proposed that late graft failure in this case was due to variant A of HHV-6.
Rosenfeld
C S
CS
Texas Oncology, Dallas, USA.
Rybka
W B
WB
Weinbaum
D
D
Carrigan
D R
DR
Knox
K K
KK
Andrews
D F
DF
Shadduck
R K
RK
D000328:Adult; D001855:Bone Marrow Diseases / Q000150:complications* / Q000821:virology; D016026:Bone Marrow Transplantation; D006084:Graft Rejection / Q000821:virology*; D006564:Herpesviridae / Q000302:isolation & purification*; D006566:Herpesviridae Infections / Q000150:complications* / Q000821:virology; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000601:surgery*; D008297:Male