Effective treatment with alpha 1-protease inhibitor of chronic cutaneous vasculitis associated with alpha 1-antitrypsin deficiency.
The primary serum proteinase inhibitor is alpha 1-antitrypsin, and deficiency of this enzyme has been associated with a variety of systemic and cutaneous disorders. We report cutaneous vasculitis in a 49-year-old man with alpha 1-antitrypsin deficiency. His condition persisted despite treatment with colchicine, prednisone, and antibiotics but has been controlled by the administration of alpha 1-protease inhibitor.
Dowd
S K
SK
Division of Dermatology, University of Louisville School of Medicine, KY, USA.
Rodgers
G C
GC
Callen
J P
JP
D002908:Chronic Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D014657:Vasculitis / Q000209:etiology / Q000628:therapy*; D000515:alpha 1-Antitrypsin / Q000627:therapeutic use*; D019896:alpha 1-Antitrypsin Deficiency
D000515:alpha 1-Antitrypsin