title: Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to rapamycin biosynthesis.
abstract: Phosphate, ammonium and magnesium salts interfered with rapamycin production by Streptomyces hygroscopicus at concentrations optimal for growth. These observations point to the existence of phosphorus, magnesium and nitrogen-negative regulation mechanisms for rapamycin biosynthesis. On the other hand, Fe2+ stimulated rapamycin production at concentrations greater than that required for growth.
authors.affiliation: Fermentation Microbiology Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA.
authors.forename: Y R
authors.initials: YR
authors.lastname: Cheng
authors.forename: L
authors.initials: L
authors.lastname: Hauck
authors.forename: A L
authors.initials: AL
authors.lastname: Demain
mesh_terms: D000935:Antifungal Agents / Q000096:biosynthesis*; D007501:Iron / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology*; D010710:Phosphates / Q000494:pharmacology*; D011090:Polyenes / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D020123:Sirolimus; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000935:Antifungal Agents; D010710:Phosphates; D011090:Polyenes; D000644:Quaternary Ammonium Compounds; D007501:Iron; D008274:Magnesium; D020123:Sirolimus