title: A Xenopus c-kit-related receptor tyrosine kinase expressed in migrating stem cells of the lateral line system.
abstract: The mammalian c-kit receptor tyrosine kinase gene is required during embryogenesis for the survival and/or proliferation of three migrating stem cell populations: primordial germ cells, haematopoietic stem cells and neural crest-derived melanoblasts. We have cloned a Xenopus gene, XKrk1, whose closest relative is c-kit. Differences in the expression pattern suggest that XKrk1 is not the Xenopus homologue of c-kit; however, it is expressed in a migrating stem cell population, the precursor cells for the mechanosensory lateral line system. XKrk1 is the first reported marker for lateral line stem cells.
authors.affiliation: Wellcome/CRC Institute, University of Cambridge, UK.
authors.forename: C V
authors.initials: CV
authors.lastname: Baker
authors.forename: C R
authors.initials: CR
authors.lastname: Sharpe
authors.forename: N P
authors.initials: NP
authors.lastname: Torpey
authors.forename: J
authors.initials: J
authors.lastname: Heasman
authors.forename: C C
authors.initials: CC
authors.lastname: Wylie
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002465:Cell Movement; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D008465:Mechanoreceptors / Q000196:embryology*; D008969:Molecular Sequence Data; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D013234:Stem Cells / Q000166:cytology*; D014981:Xenopus
chemical_list: D020794:Receptor Protein-Tyrosine Kinases