Phosphate, ammonium, magnesium and iron nutrition of Streptomyces hygroscopicus with respect to rapamycin biosynthesis.
Phosphate, ammonium and magnesium salts interfered with rapamycin production by Streptomyces hygroscopicus at concentrations optimal for growth. These observations point to the existence of phosphorus, magnesium and nitrogen-negative regulation mechanisms for rapamycin biosynthesis. On the other hand, Fe2+ stimulated rapamycin production at concentrations greater than that required for growth.
Cheng
Y R
YR
Fermentation Microbiology Laboratory, Massachusetts Institute of Technology, Cambridge 02139, USA.
Hauck
L
L
Demain
A L
AL
D000935:Antifungal Agents / Q000096:biosynthesis*; D007501:Iron / Q000494:pharmacology*; D008274:Magnesium / Q000494:pharmacology*; D010710:Phosphates / Q000494:pharmacology*; D011090:Polyenes / Q000378:metabolism*; D000644:Quaternary Ammonium Compounds / Q000494:pharmacology*; D020123:Sirolimus; D013302:Streptomyces / Q000378:metabolism*
D000935:Antifungal Agents; D010710:Phosphates; D011090:Polyenes; D000644:Quaternary Ammonium Compounds; D007501:Iron; D008274:Magnesium; D020123:Sirolimus