Toxicity of sulphur-containing compounds to neuronal cell lines.
Cysteine and its metabolites cysteine sulphinic acid (CSA) and taurine (TA) were shown to be toxic to human and rat neuronal cell lines. However, the mechanisms of action of CSA and TA appeared to be different. As MND/ALS patients have high plasma and CSF cysteine levels, they may have increased levels of neurotoxins in vivo, since cysteine was more toxic than CSA in the assay system used. Cysteic acid, homocysteic acid, BMAA and BOAA were also toxic to the cell lines used.
Pean
A R
AR
School of Biochemistry, University of Birmingham, Edgbaston, UK.
Parsons
R B
RB
Waring
R H
RH
Williams
A C
AC
Ramsden
D B
DB
D000818:Animals; D002460:Cell Line; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D009474:Neurons / Q000187:drug effects* / Q000201:enzymology; D009498:Neurotoxins / Q000633:toxicity*; D051381:Rats; D013455:Sulfur / Q000633:toxicity*; D014407:Tumor Cells, Cultured
D009498:Neurotoxins; D013455:Sulfur; D007770:L-Lactate Dehydrogenase