Further brominated bis- and tris-indole alkaloids from the deep-water New Caledonian marine sponge Orina Sp.
Two tris-indole alkaloids, (+/-) gelliusines A and B [1], have been isolated for the first time from a marine source, the New Caledonian sponge, Orina sp. (or Gellius sp.), along with five further indole constituents [2-6]. Compound 6 has been identified as 2,2-bis-(6'-bromo-3'-indolyl(-ethylamine, previously isolated from the tunicate Didemnum candidum, but the remaining four indoles [2-5] are novel compounds. These showed anti-serotonin activity and a strong affinity for somatostatin and neuropeptide Y receptors in receptor-binding assays.
Bifulco
G
G
Dipartimento di Chimica delle Sostanze Naturali, Università degli Studi di Napoli Ferderico II, Italy.
Bruno
I
I
Riccio
R
R
Lavayre
J
J
Bourdy
G
G
D000470:Alkaloids / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D015740:Calcitonin Gene-Related Peptide / Q000378:metabolism; D002460:Cell Line; D019004:Galanin / Q000378:metabolism; D006168:Guinea Pigs; D006801:Humans; D007211:Indoles / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009510:New Caledonia; D011161:Porifera / Q000737:chemistry*; D051381:Rats; D018091:Receptors, AMPA / Q000037:antagonists & inhibitors; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D018028:Receptors, Neurotensin / Q000187:drug effects; D018005:Receptors, Vasoactive Intestinal Peptide / Q000187:drug effects; D012702:Serotonin Antagonists / Q000302:isolation & purification / Q000494:pharmacology
D000470:Alkaloids; D007211:Indoles; D018091:Receptors, AMPA; D016194:Receptors, N-Methyl-D-Aspartate; D018028:Receptors, Neurotensin; D018005:Receptors, Vasoactive Intestinal Peptide; D012702:Serotonin Antagonists; C091091:gelliusine A; D019004:Galanin; D015740:Calcitonin Gene-Related Peptide