title: An unwanted side effect of hydroxyurea in a patient with idiopathic myelofibrosis.
abstract: A patient with idiopathic myelofibrosis is reported who developed a drug fever after treatment with hydroxyurea, a generally effective and well-tolerated drug in chronic myeloproliferative syndromes. Typically, this form of fever develops after a few weeks of exposure to the drug and disappears with discontinuation of the drug. Possible interactions with prostaglandin or leukotriene metabolism may play a role.
authors.affiliation: Department of Internal Medicine, De Wever Hospital, Heerlen, The Netherlands.
authors.forename: M J
authors.initials: MJ
authors.lastname: Starmans-Kool
authors.forename: M M
authors.initials: MM
authors.lastname: Fickers
authors.forename: M A
authors.initials: MA
authors.lastname: Pannebakker
mesh_terms: D000368:Aged; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D008297:Male; D055728:Primary Myelofibrosis / Q000188:drug therapy*
chemical_list: D006918:Hydroxyurea