[Reversal of acute hypoxic pulmonary hypertension with inhalation of nitric oxide].
The effect of inhalation of nitric oxide (NO) gas on acute hypoxic pulmonary hypertension was studied. Eighteen mongrel dogs were divided into two groups: hypoxic control group (FIO2 = 11%, n = 10) and NO inhalation group (FIO2 = 11%, NO inspiratory concentration = 44 ppm, n = 8). In the control group, the increase percent of mean pulmonary arterial pressure (mPAP) was 30.6% +/- 5.5%, 47.8% +/- 11.3%, 46.0% +/- 9.3%, 37.0% +/- 6.3% respectively at 5th, 15th, 30th and 60th minute after hypoxic ventilation. In the NO inhalation group, mPAP increment was 4.6% +/- 3.7%, 0.5% +/- 6.0%, 0.7% +/- 6.8%, 7.2% +/- 6.1%, respectively (all P < 0.01, compared with the control group). Inhaled nitric oxide also reduced the pulmonary vascular resistance significantly during hypoxic ventilation, but it had no remarkable effect on the systemic arterial pressure and vascular resistance. These results indicated that inhalation of nitric oxide gas may be used to treat acute hypoxic pulmonary hypertension.
Cao
W
W
Department of Respiratory Medicine, Peking Union Medical College Hospital, Beijing.
Zhu
Y
Y
Luo
W
W
D000280:Administration, Inhalation; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects*; D004285:Dogs; D006976:Hypertension, Pulmonary / Q000503:physiopathology*; D000860:Hypoxia / Q000150:complications*; D009569:Nitric Oxide / Q000494:pharmacology*; D014655:Vascular Resistance / Q000187:drug effects*
D009569:Nitric Oxide