title: Frequency analysis of evoked otoacoustic emissions in Meniére's disease.
abstract: Our study was designed to establish a diagnostic significance in Meniére's disease by means of evoked otoacoustic emissions (EOAEs). EOAEs were recorded from patients with Meniére, and the "main frequency" of the emissions, which shows the maximum peak in the frequency spectrum, was examined as a variable. The main frequencies in ears with Meniére ranged mainly from 0.8 kHz to 1.1 kHz and were to be found at lower frequencies than in ears with normal hearing whose range was mainly from 1.0 kHz to 1.6 kHz. Furthermore, in some ears with Meniére, the main frequencies changed from lower to higher after administration of osmotic diuretics such as glycerol or isosorbide. On the basis of these results it was speculated that in ears with Meniére, lower frequency dominant emissions might be elicited by modification of the basilar membrane in endolymphatic hydrops and that the main frequencies might change from lower to higher with reduction of endolymphatic hydrops induced by osmotic diuretics. It was considered that the EOAE testing might be useful for a diagnosis of endolymphatic hydrops in Meniére.
authors.affiliation: Department of Otolaryngology, Osaka City University Medical School, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Kubo
authors.forename: T
authors.initials: T
authors.lastname: Sakashita
authors.forename: M
authors.initials: M
authors.lastname: Kusuki
authors.forename: Y
authors.initials: Y
authors.lastname: Nakai
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001299:Audiometry; D005260:Female; D005990:Glycerol; D006309:Hearing; D006801:Humans; D007547:Isosorbide / Q000627:therapeutic use; D008297:Male; D008575:Meniere Disease / Q000188:drug therapy / Q000503:physiopathology*; D008875:Middle Aged; D017084:Otoacoustic Emissions, Spontaneous; D012016:Reference Values
chemical_list: D005990:Glycerol; D007547:Isosorbide