Influence of age on the stereoselective disposition and metabolism of ibuprofen in humans.
Ibuprofen is widely used in the treatment of pain and inflammatory disorders. Metabolic events that occur within the pharmacokinetic behavior of ibuprofen enantiomers create problems for patients, particularly the elderly and those with conditions where the maintenance of renal function is prostaglandin-dependent. Eighteen healthy volunteers of two different age groups received an oral dose of 800 mg of racemic ibuprofen, and the pharmacokinetic profiles of (R)- and (S)-ibuprofen metabolism were examined. The results showed reduced ibuprofen clearance in the older group, as indicated by elevated values of T1/2 (R), AUC(R) and AUC(S), as well as reduced clearance/fraction of absorption (R). Clearly, age is a risk factor for ibuprofen-related renal failure. The aging process, functional changes in drug metabolism and disposition contribute to the increased incidence of ibuprofen-related toxicity in the elderly.
Chen
C Y
CY
Department of Family Medicine College of Medicine National Taiwan University, Taipei, R.O.C.
D000328:Adult; D000367:Age Factors; D005260:Female; D006801:Humans; D007052:Ibuprofen / Q000378:metabolism / Q000493:pharmacokinetics*; D008297:Male; D008657:Metabolic Clearance Rate; D008875:Middle Aged; D013237:Stereoisomerism; D014018:Tissue Distribution
D007052:Ibuprofen