Tidal flow volume loops and inflammatory indicators in small children.
Serum eosinophilic cationic protein (sECP) serum myeloperoxidase (sMPO) and tidal flow volume loops were measured in 41 awake children with at least two episodes of bronchopulmonary obstruction, at least 3 weeks after an acute episode, and in 38 control children, all below 2 years of age. Reversibility to salbutamol was assessed in 26 cases and 24 controls. The baseline ratio of time to peak flow to total expiratory time (Tpef/Te) was significantly lower in cases (0.21) than in controls (0.33). sECP was significantly higher in cases (21.9 micrograms/l) than in controls (14.0 micrograms/l), and correlated significantly (r = 0.70) with the percentage change in Tpef/Te from before to after salbutamol. sMPO did not differ significantly between the two groups.
Carlsen
K H
KH
Voksentoppen Centre for Asthma and Allergy, Oslo, Norway.
Carlson
K C
KC
Halvorsen
R
R
D000402:Airway Obstruction / Q000150:complications / Q000175:diagnosis*; D000420:Albuterol; D001249:Asthma / Q000150:complications / Q000175:diagnosis*; D015415:Biomarkers; D001798:Blood Proteins / Q000032:analysis*; D016022:Case-Control Studies; D002675:Child, Preschool; D003937:Diagnosis, Differential; D047091:Eosinophil Granule Proteins; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D010366:Peak Expiratory Flow Rate / Q000187:drug effects; D009195:Peroxidase / Q000097:blood*; D012008:Recurrence; D012135:Respiratory Sounds / Q000209:etiology*; D012260:Ribonucleases; D013990:Tidal Volume / Q000187:drug effects*
D015415:Biomarkers; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D009195:Peroxidase; D012260:Ribonucleases; D000420:Albuterol