title: Cerebellar volume asymmetries are related to handedness: a quantitative MRI study.
abstract: Four cerebellar subregions were delineated (left, right; anterior, posterior), and their volumes measured on contiguous 3.1 mm coronal MR images in 15 dextral and 8 nondextral healthy control subjects. (1) Left and right cerebellar hemisphere volume asymmetries interacted with anterior-posterior level (anterior: right > left; posterior: left > right), following a pattern commonly found in the neocortex; (2) A significant handedness effect was found (P < or =0.01) on a composite index of cerebellar asymmetry, such that dextrals showed more asymmetry than nondextrals. These data suggest that the same pattern of asymmetries observed at the neocortical level is also present in the metencephalon. These asymmetries, possibly resulting from multiple developmental growth gradients acting on the metencephalon early in gestation, are associated with handedness differences in adulthood.
authors.affiliation: Behavioral Epilepsy Program, Allegheny Neuropsychiatric Institute, Medical College of Pennsylvania, Pittsburgh, USA.
authors.forename: P J
authors.initials: PJ
authors.lastname: Snyder
authors.forename: R M
authors.initials: RM
authors.lastname: Bilder
authors.forename: H
authors.initials: H
authors.lastname: Wu
authors.forename: B
authors.initials: B
authors.lastname: Bogerts
authors.forename: J A
authors.initials: JA
authors.lastname: Lieberman
mesh_terms: D000328:Adult; D002531:Cerebellum / Q000033:anatomy & histology* / Q000502:physiology*; D005260:Female; D007839:Functional Laterality / Q000502:physiology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male