Pharmacologic enhancement of wound healing.
The field of pharmacologic modulation of soft tissue repair is in its infancy. Although the soluble, cellular, and insoluble mediators that govern repair have not been elucidated, the application of pharmacologic concentrations of purified polypeptide growth factors, cytokines, and matrix molecules has nonetheless resulted in the acceleration of normal repair and the reversal of deficient repair in a wide variety of dermal wound models in animals. However, early clinical results using these factors have been less than encouraging, and their potential roles in the armamentarium of chronic wound therapies remain to be established.
Pierce
G F
GF
Department of Preclinical Sciences, PRIZM Pharmaceuticals, San Diego, California 92121, USA.
Mustoe
T A
TA
D000818:Animals; D016207:Cytokines / Q000494:pharmacology*; D016326:Extracellular Matrix Proteins / Q000494:pharmacology*; D006133:Growth Substances / Q000494:pharmacology*; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism; D010455:Peptides / Q000494:pharmacology*; D003668:Pressure Ulcer / Q000503:physiopathology / Q000628:therapy; D014945:Wound Healing / Q000187:drug effects* / Q000502:physiology
D016207:Cytokines; D016326:Extracellular Matrix Proteins; D006133:Growth Substances; D018836:Inflammation Mediators; D010455:Peptides