Cyclic GMP as a second messenger in the cardiovascular system.
To delineate the importance of cyclic GMP (cGMP) as a second messenger for signal transduction within the cell, catalytic and regulatory features of the proteins involved in the synthesis and degradation of cGMP, i.e., guanylate cyclases and phosphodiesterases, are described. Characteristic features of cGMP-dependent protein kinases as intracellular receptors for cGMP and the contribution of this enzyme to the physiological functions of cGMP in the cardiovascular system are discussed.
Imai
S
S
Department of Pharmacology, Niigata University School of Medicine, Japan.
D000595:Amino Acid Sequence; D000818:Animals; D009320:Atrial Natriuretic Factor / Q000502:physiology; D002320:Cardiovascular Physiological Phenomena; D006152:Cyclic GMP / Q000737:chemistry / Q000378:metabolism / Q000502:physiology*; D004768:Enterotoxins; D004926:Escherichia coli; D006162:Guanylate Cyclase / Q000235:genetics / Q000378:metabolism; D008322:Mammals; D008969:Molecular Sequence Data; D009569:Nitric Oxide / Q000502:physiology; D010727:Phosphoric Diester Hydrolases / Q000378:metabolism; D011494:Protein Kinases / Q000378:metabolism; D017461:Receptors, Atrial Natriuretic Factor / Q000235:genetics / Q000378:metabolism; D015290:Second Messenger Systems / Q000502:physiology*
D004768:Enterotoxins; D009569:Nitric Oxide; D009320:Atrial Natriuretic Factor; D011494:Protein Kinases; D010727:Phosphoric Diester Hydrolases; D006162:Guanylate Cyclase; D017461:Receptors, Atrial Natriuretic Factor; D006152:Cyclic GMP