Basal cell tumor in a Japanese macaque (Macaca fuscata).
A rare case of basal cell tumor of the skin in a wild-caught female Japanese macaque (Macaca fuscata) was studied. Tumor growth, which was composed of cells resembling basal cells, was observed in the dermis and subcutis and showed a mixture of ribbon, solid, glandular, and cystic patterns. The tumor was separated from surrounding normal tissue by a compressed zone of fibrous connective tissue. The nuclei were round and hyperchromatic and possessed a single centrally located nucleolus. Mitotic figures were common. Immunohistochemically, a positive reaction for epithelial membrane antigen, keratin, and cytokeratin AE3 was evident. Electron microscopic examination revealed a small number of tonofilaments in the cytoplasm.
Yanai
T
T
Department of Veterinary Pathology, Faculty of Agriculture, Gifu University, Japan.
Wakabayashi
S
S
Masegi
T
T
Iwasaki
T
T
Yamazoe
K
K
Ishikawa
K
K
Ueda
K
K
D000818:Animals; D002280:Basal Cell Carcinoma / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*; D005260:Female; D007150:Immunohistochemistry; D008251:Macaca; D008992:Monkey Diseases / Q000473:pathology*; D012878:Skin Neoplasms / Q000473:pathology / Q000648:ultrastructure / Q000662:veterinary*