Cerebrospinal fluid purine metabolites and pyrimidine bases after brief febrile convulsions.
Adenosine monophosphate, inosine monophosphate, inosine, adenosine, guanosine, adenine, guanine, hypoxanthine, xanthine, uric acid, and pyrimidines bases were determined in cerebrospinal fluid (CSF) of 52 children after simple febrile seizures and in a control group of 63 children. There was no statistically significant difference between the two groups for any of these metabolites, suggesting that simple febrile seizures (SFS) neither significantly disturb the metabolism of nucleotides, nucleosides, or bases nor significantly deplete neuron adenosine ATP levels. Therefore, they do not appear to constitute a threat of neuronal damage.
Castro-Gago
M
M
Departamento de Pediatría, Hospital General de Galicia, Clínico-Universitario, Santiago de Compostela, Spain.
Cid
E
E
Trabazo
S
S
Pavón
P
P
Camiña
F
F
Rodríguez-Segade
S
S
Einís Puñal
J
J
Rodríguez-Nuñez
A
A
D002675:Child, Preschool; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D009705:Nucleosides / Q000378:metabolism; D009711:Nucleotides / Q000378:metabolism; D011685:Purine Nucleotides / Q000378:metabolism; D011687:Purines / Q000134:cerebrospinal fluid* / Q000378:metabolism*; D011743:Pyrimidines / Q000134:cerebrospinal fluid* / Q000378:metabolism; D003294:Seizures, Febrile / Q000134:cerebrospinal fluid*
D009705:Nucleosides; D009711:Nucleotides; D011685:Purine Nucleotides; D011687:Purines; D011743:Pyrimidines