Prospects for hepatitis C vaccine.
The genetic and serological heterogeneity of hepatitis C virus and reinfections will make the development of a broad spectrum effective hepatitis C vaccine difficult. Important steps are identification of neutralising antibodies; reproducible techniques for tissue culture of HCV; the application of methods used for the development of vaccines against flaviviruses and pestiviruses, and the application of gene transfer techniques.
Zuckerman
A J
AJ
WHO Collaborating Centre for Reference and Research on Viral Diseases, Royal Free Hospital and School of Medicine, London, U.K.
Zuckerman
J N
JN
D000818:Animals; D003001:Cloning, Molecular; D005544:Forecasting; D016679:Genome, Viral; D016174:Hepacivirus / Q000235:genetics*; D006526:Hepatitis C / Q000276:immunology* / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D014761:Viral Hepatitis Vaccines
D014761:Viral Hepatitis Vaccines