Severe accidental dapsone overdose.
Acute poisoning from excessive dapsone (4,4-diaminodiphenylsulfone) intake in uncommon in the United States; no cases were reported during 1992. However, with the increasing use of dapsone for diseases other than leprosy and dermatitis herpetiformis, such as acne vulgaris, psoriasis, and Pneumocystis carinii pneumonia infection in acquired immunodeficiency syndrome, clinicians should be aware of potential toxicities. This report describes a case of accidental dapsone intoxication resulting in severe cyanosis with a modest elevation in methemoglobin concentration.
McGoldrick
M D
MD
Albany Medical College, NY, USA.
Bailie
G R
GR
D002606:Charcoal / Q000627:therapeutic use; D003490:Cyanosis / Q000139:chemically induced* / Q000188:drug therapy; D003622:Dapsone / Q000506:poisoning*; D003874:Dermatitis Herpetiformis / Q000188:drug therapy; D062787:Drug Overdose; D006801:Humans; D008297:Male; D008708:Methemoglobinemia / Q000139:chemically induced* / Q000188:drug therapy; D008751:Methylene Blue / Q000627:therapeutic use; D008875:Middle Aged; D011041:Poisoning / Q000628:therapy
D002606:Charcoal; D003622:Dapsone; D008751:Methylene Blue