Protection against chemotherapy-induced alopecia by cyclosporin A in the newborn rat animal model.
BACKGROUND
We have previously shown that several agents will protect against chemotherapy-induced alopecia in the newborn rat animal model. Such protective agents render the hair follicle keratinocytes resistant to chemotherapy possibly by the expression of P-glycoprotein (Pgp). Cyclosporin A (CSA) is a potent inhibitor of Pgp.


RESULTS
Efficacy of CSA was tested in its effects on chemotherapy-induced alopecia in the newborn rat animal model. CSA, when applied topically, protected rats from local alopecia induced by various agents.


CONCLUSIONS
The mechanism of protection by CSA and its relationship to Pgp remain uncertain. The potential clinical applicability of this observation remains to be determined.
Hussein
A M
AM
Bone Marrow Transplant Program, Duke University Medical Center, Durham, N.C., USA.
Stuart
A
A
Peters
W P
WP
D000279:Administration, Cutaneous; D000505:Alopecia / Q000139:chemically induced* / Q000517:prevention & control*; D000818:Animals; D000831:Animals, Newborn; D000970:Antineoplastic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003520:Cyclophosphamide / Q000008:administration & dosage / Q000009:adverse effects; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003561:Cytarabine / Q000008:administration & dosage / Q000009:adverse effects; D004195:Disease Models, Animal; D005047:Etoposide / Q000008:administration & dosage / Q000009:adverse effects; D007274:Injections, Intraperitoneal; D051381:Rats; D017207:Rats, Sprague-Dawley
D000970:Antineoplastic Agents; D003561:Cytarabine; D005047:Etoposide; D016572:Cyclosporine; D003520:Cyclophosphamide