Possible role of calcium in the cardiovascular effects of prolonged administration of gamma-HCH (lindane) in rats.
Gamma-HCH (lindane) administered for long durations is reported to cause toxic cardiovascular effects. Present study was carried out to assess the changes in cardiovascular activity and cellular calcium homeostatic mechanisms in rats administered 3 mg kg-1 day-1 of gamma-HCH p.o. for 6 weeks. The changes in electrocardiogram were marked by a decrease in R-R interval and the amplitude of the P wave by 53% and 50%, respectively. The amplitude of R and T waves was increased by 65% and 58%, respectively. Calcium-45 influx was increased in atrial trabeculae (33%) and in papillary muscle (10%). The plasma calcium concentration was increased (32%) and Ca,K-ATPase activity in heart was decreased (50%). It is suggested on the basis of these findings that cellular calcium homeostatic mechanisms are involved in the cardiovascular effects of gamma-HCH administered chronically in rats.
Anand
M
M
Industrial Toxicology Research Centre, Mahatma Gandhi Marg, Lucknow, India.
Meera
P
P
Kumar
R
R
Gupta
G S
GS
Tripathi
O
O
Srimal
R C
RC
D000251:Adenosine Triphosphatases / Q000378:metabolism; D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D002118:Calcium / Q000097:blood / Q000378:metabolism*; D004562:Electrocardiography / Q000187:drug effects; D006321:Heart / Q000187:drug effects* / Q000502:physiology; D006339:Heart Rate / Q000187:drug effects; D001556:Hexachlorocyclohexane / Q000633:toxicity*; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009206:Myocardium / Q000378:metabolism; D051381:Rats
D007306:Insecticides; D001556:Hexachlorocyclohexane; D000251:Adenosine Triphosphatases; C029321:calcium potassium ATPase; D002118:Calcium