title: Preemptive analgesia.
abstract: Preemptive analgesia describes a situation where the administration of a pharmacological agent administered before the onset of a painful stimulus causes a decrease in the intensity of pain felt, and subsequently there is a decrease in the total amount of analgesic required compared with the administration of an agent after a painful stimulus. It is best understood if it is thought of as a block to afferent impulses that are trying to reach the central nervous system before a tissue injury. Preemptive analgesia, administered in the form of narcotics, nonsteroidal antiinflammatory agents, or local anesthetics, is thought to alter peripheral and central sensitization to nociceptive impulses.
authors.forename: M A
authors.initials: MA
authors.lastname: Golinski
authors.forename: D M
authors.initials: DM
authors.lastname: Fill
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D006801:Humans; D009475:Neurons, Afferent / Q000187:drug effects; D010149:Postoperative Pain / Q000188:drug therapy* / Q000503:physiopathology; D011292:Premedication / Q000379:methods*
chemical_list: D000700:Analgesics