title: The cation-independent mannose-6-phosphate receptor binds to soluble GPI-linked proteins via mannose-6-phosphate.
abstract: The cation-independent mannose-6-phosphate/insulin-like growth factor II receptor has been observed to bind to soluble forms of glycosyl-phosphatidylinositol-linked molecules, one of mammalian origin (rat Thy-1) and two of protozoan origins. Of the two phosphate groups found on the soluble forms of the protozoan glycosyl-phosphatidylinositol-linked molecules: (i) the internal mannose-6-phosphate diester (which forms a part of the ethanolamine bridge) and (ii) the inositol-1,2 cyclic phosphate group (which arises after cleavage of the membrane associated form with phosphatidylinositol-specific phospholipase C), only the former appears to be recognized by the mannose-6-phosphate/insulin-like growth factor II receptor, as mild acid hydrolysis which destroys the latter has been observed not to affect the receptor binding site.
authors.affiliation: Glycosciences Laboratory, Northwick Park Hospital, Middx, UK.
authors.forename: P J
authors.initials: PJ
authors.lastname: Green
authors.forename: M A
authors.initials: MA
authors.lastname: Ferguson
authors.forename: P J
authors.initials: PJ
authors.lastname: Robinson
authors.forename: T
authors.initials: T
authors.lastname: Feizi
mesh_terms: D000818:Animals; D002240:Carbohydrate Sequence; D002417:Cattle; D017261:Glycosylphosphatidylinositols / Q000737:chemistry / Q000378:metabolism*; D007295:Inositol Phosphates / Q000378:metabolism; D018320:Leishmania major / Q000737:chemistry; D008360:Mannosephosphates / Q000378:metabolism*; D008969:Molecular Sequence Data; D017527:Receptor, IGF Type 2 / Q000737:chemistry / Q000378:metabolism*; D012995:Solubility; D013329:Structure-Activity Relationship; D014643:Variant Surface Glycoproteins, Trypanosoma / Q000737:chemistry
chemical_list: D017261:Glycosylphosphatidylinositols; D007295:Inositol Phosphates; D008360:Mannosephosphates; D017527:Receptor, IGF Type 2; D014643:Variant Surface Glycoproteins, Trypanosoma; C027693:mannose-6-phosphate