title: The use of glycolic acid as a peeling agent.
abstract: Glycolic acid is a member of the AHA family, which occurs naturally in foods and has been used for centuries as a cutaneous rejuvenation treatment. Recently it has proved to be a versatile peeling agent and it is now widely used to treat many defects of the epidermis and papillary dermis in a variety of strengths, ranging from 20% to 70%, depending on the condition being treated. People of almost any skin type and color are candidates, and almost any area of the body can be peeled. Several weeks prior to a peel the skin may be prepared with topical tretinoin or glycolic acid, and immediately prior to the peel the skin may be degreased with a variety of agents. Following the peel the skin is carefully observed for any complications such as hyperpigmentation and infection. Results are maintained with serial peels and at-home use of tretinoin or glycolic acid, as well as sun avoidance. The glycolic acid can be applied simultaneously with TCA and is another technique for a medium-depth peel. Comparison of 35% TCA-treated skin with 70% glycolic acid-treated skin examined histologically at different times reveals similar changes in papillary dermis connective tissue proteins, epidermal necrosis seen only with TCA, and reversion at 2 years postpeel to pretreatment appearance.
authors.affiliation: Department of Dermatology, University of California Los Angeles School of Medicine, USA.
authors.forename: H
authors.initials: H
authors.lastname: Murad
authors.forename: A T
authors.initials: AT
authors.lastname: Shamban
authors.forename: P S
authors.initials: PS
authors.lastname: Premo
mesh_terms: D002615:Chemexfoliation / Q000009:adverse effects / Q000379:methods; D062109:Dermatologic Surgical Procedures; D004338:Drug Combinations; D005145:Face / Q000601:surgery; D006016:Glycolates / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D010347:Patient Care Planning; D010859:Pigmentation Disorders / Q000601:surgery; D012867:Skin / Q000187:drug effects / Q000473:pathology; D015595:Skin Aging; D017592:Skin Care
chemical_list: D004338:Drug Combinations; D006016:Glycolates; C031149:glycolic acid