title: Sutureless anastomosis of the small intestine and the colon in pigs using an absorbable intraluminal stent and fibrin glue.
abstract: A new sutureless anastomosis technique employing a sliding absorbable intraluminal nontoxic stent (SAINT) and fibrin glue with limited (minutes) stump margin pressure is described. Fifty-one (27 small intestine, 24 colon) SAINT anastomoses were performed in 31 Landrace pigs (25-35 kg). Controls consisted of 48 (26 small intestine, 22 colon) continuous single-layer submucosal anastomoses in 26 pigs. SAINTs, which dissolve in about 30-60 min, were formed from heated sucrose and water poured into handcrafted aluminum molds. Follow-up from 7 to 540 days showed no stenosis or anastomotic imperfections in the latter part of the experiment after the SAINT production and surgical techniques were improved. The SAINT group had fewer site adhesions, faster healing, less foreign body reaction, and fewer lymphocytes than the control group. Initial results indicate that the SAINT-fibrin glue procedure may be an effective sutureless anastomotic method from the duodenum to the sigmoid colon.
authors.affiliation: Crozer-Chester Medical Center, Upland, PA 19013, USA.
authors.forename: M B
authors.initials: MB
authors.lastname: Detweiler
authors.forename: V
authors.initials: V
authors.lastname: Durastante
authors.forename: A
authors.initials: A
authors.lastname: Verbo
authors.forename: I
authors.initials: I
authors.lastname: Muttillo
authors.forename: M
authors.initials: M
authors.lastname: Piantelli
authors.forename: J W
authors.initials: JW
authors.lastname: Kobos
authors.forename: A
authors.initials: A
authors.lastname: Antinori
authors.forename: P
authors.initials: P
authors.lastname: Granone
authors.forename: P
authors.initials: P
authors.lastname: Magistrelli
authors.forename: A
authors.initials: A
authors.lastname: Picciocchi
mesh_terms: D000714:Anastomosis, Surgical / Q000379:methods; D000818:Animals; D003106:Colon / Q000601:surgery*; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005500:Follow-Up Studies; D007408:Intestinal Absorption; D007421:Intestine, Small / Q000601:surgery*; D015607:Stents; D013552:Swine
chemical_list: D015718:Fibrin Tissue Adhesive