title: Feeding-induced changes in energy expenditure in children with cystic fibrosis.
abstract: Seven children with cystic fibrosis (aged 7 to 12 years) were studied in the fasted and fed states. Using a primed, constant, intravenous infusion of NaH13CO3, the rate of appearance of CO2 (RaCO2) was estimated. Net CO2 excretion (VCO2) was also measured. Energy expenditure was calculated using the food quotient. RaCO2 (mean +/- SD) (mumol.kg-1.min-1) in the fasted and fed states (297 +/- 59 and 359 +/- 67) was 117% and 105% of VCO2 (259 +/- 48 and 352 +/- 72). Feeding induced a 23% and a 37% increase in RaCO2 and VCO2, respectively, and respective 19% and 33% increases in energy expenditure (p < .05). Measurement of CO2 production by isotopic dilution is a useful index of group changes in energy expenditure, including those induced by feeding.
authors.affiliation: Department of Pediatrics, Ohio State University College of Medicine, Columbus, USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Horswill
authors.forename: L
authors.initials: L
authors.lastname: Kien
authors.forename: W B
authors.initials: WB
authors.lastname: Zipf
authors.forename: K S
authors.initials: KS
authors.lastname: McCoy
mesh_terms: D001833:Body Temperature Regulation; D002245:Carbon Dioxide / Q000378:metabolism; D002247:Carbon Isotopes; D002648:Child; D003550:Cystic Fibrosis / Q000378:metabolism*; D002149:Energy Intake; D004734:Energy Metabolism; D005215:Fasting; D005502:Food; D006801:Humans; D007700:Kinetics
chemical_list: D002247:Carbon Isotopes; D002245:Carbon Dioxide