[Interrelationship between structural variants of the apolipoprotein B and ischemic heart disease and plasma lipid levels].
Xba I and EcoR I polymorphism of the apolipoprotein B (APOB) gene was studied by PCR. A significant increase in the frequency of allele X+ and haplotype H+E+ was demonstrated in patients with coronarographically documented coronary heart disease (CHD) over that of the general population. Association of allele E- with increased levels of serum triglycerides was found. The results provide evidence about the contribution of structural variants of the APOB gene to determining CHD.
Stepanov
V A
VA
Puzyrev
V P
VP
Lemza
S V
SV
Karpov
R S
RS
Fedorov
A Iu
AIu
D000328:Adult; D000483:Alleles; D001055:Apolipoproteins B / Q000235:genetics*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged
D001055:Apolipoproteins B; D005819:Genetic Markers; D008055:Lipids