Antidiuretic hormone (ADH) and endolymphatic hydrops.
Plasma antidiuretic hormone (p-ADH) concentrations were determined with a radioimmunoassay, using a reversed-phase C18 silica column, in 300 patients with vertigo, dizziness and/or deafness; 119 of them had a diagnosis of Menière's disease. The p-ADH level was significantly elevated in patients with Meniere's disease and others with endolymphatic hydrops, e.g. cochlear Menière's disease or delayed hydrops. By contrast, the p-ADH level was not so high in cases without the endolymphatic hydrops. The increase in the p-ADH level was closely linked to vertigo attacks, the glycerol test results and an enhanced negative summating potential (-SP) in electrocochleogram (ECochG). These results lead to the assumption that disorders of ADH-dependent hormonal control in the inner ear may constitute the possible mechanism underlying vertiginous attacks and deafness in patients with endolymphatic hydrops.
Takeda
T
T
Department of Otorhinolaryngology, Kochi Medical School, Japan.
Kakigi
A
A
Saito
H
H
D003051:Cochlea / Q000503:physiopathology; D003638:Deafness / Q000097:blood; D004244:Dizziness / Q000097:blood; D004487:Edema / Q000097:blood; D004594:Electrophysiology; D018159:Endolymphatic Hydrops / Q000097:blood*; D005990:Glycerol; D006361:Heating; D006801:Humans; D008575:Meniere Disease / Q000097:blood / Q000503:physiopathology; D014667:Vasopressins / Q000097:blood*; D014717:Vertigo / Q000097:blood
D014667:Vasopressins; D005990:Glycerol