title: Pressure stabilization is not a general property of thermophilic enzymes: the adenylate kinases of Methanococcus voltae, Methanococcus maripaludis, Methanococcus thermolithotrophicus, and Methanococcus jannaschii.
abstract: The application of 50-MPa pressure did not increase the thermostabilities of adenylate kinases purified from four related mesophilic and thermophilic marine methanogens. Thus, while it has been reported that some thermophilic enzymes are stabilized by pressure (D. J. Hei and D. S. Clark, Appl. Environ. Microbiol. 60:932-939, 1994), hyperbaric stabilization is not an intrinsic property of all enzymes from deep-sea thermophiles.
authors.affiliation: Department of Microbiology, University of Illinois, Urbana 61801, USA.
authors.forename: J
authors.initials: J
authors.lastname: Konisky
authors.forename: P C
authors.initials: PC
authors.lastname: Michels
authors.forename: D S
authors.initials: DS
authors.lastname: Clark
mesh_terms: D000263:Adenylate Kinase / Q000737:chemistry*; D004795:Enzyme Stability; D017017:Methanococcus / Q000201:enzymology*; D011312:Pressure
chemical_list: D000263:Adenylate Kinase