Antifungal activity of Aplysianin E, a cytotoxic protein of sea hare (Aplysia kurodai) eggs.
We observed for the first time that antifungal activity was exhibited by Aplysianin E (AKE), an antineoplastic and antibacterial glycoprotein purified from the eggs of Aplysia kurodai. AKE completely suppressed growth of the yeast form fungi, Saccharomyces cerevisiae A 5 8 1 A, Schizosaccharomyces pombe JY 1 and Candida albicans ATCC 36232 at a concentration of over 16 micrograms/mL. The colony-forming abilities of the fungi were also significantly decreased after contact with AKE. These results indicate that AKE has an antifungal property and that its mode of action is fungicidal.
Iijima
R
R
Faculty of Pharmaceutical Sciences, Teikyo University, Kanagawa, Japan.
Kisugi
J
J
Yamazaki
M
M
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D000903:Antibiotics, Antineoplastic / Q000494:pharmacology*; D000935:Antifungal Agents / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development; D004527:Egg Proteins / Q000494:pharmacology*; D006020:Glycopeptides; D012441:Saccharomyces cerevisiae / Q000187:drug effects / Q000254:growth & development; D012568:Schizosaccharomyces / Q000187:drug effects / Q000254:growth & development
D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D000935:Antifungal Agents; D004527:Egg Proteins; D006020:Glycopeptides; C053778:aplysianin E