Identification of additional homologues of subunits VII and VIII of the ubiquinol-cytochrome c oxidoreductase enables definition of consensus sequences.
The Candida utilis QCR7 gene encoding subunit VII of the ubiquinol-cytochrome c oxidoreductase was isolated by functional complementation of the Saccharomyces cerevisiae subunit VII-null mutant. Several other subunit VII homologues as well as homologues for subunit VIII were identified by screening the GenBank database. Some of these homologues for subunit VII could only be identified as such using a consensus sequence that was derived from the multiple sequence alignment. Definition of the consensus should facilitate further analysis of structure/function relationships in this protein.
Boumans
H
H
E.C. Slater Institute, University of Amsterdam, The Netherlands.
Berden
J A
JA
Grivell
L A
LA
D000595:Amino Acid Sequence; D001483:Base Sequence; D002175:Candida / Q000235:genetics; D016384:Consensus Sequence; D004271:DNA, Fungal; D016208:Databases, Factual; D014450:Electron Transport Complex III / Q000737:chemistry* / Q000235:genetics; D004926:Escherichia coli; D005800:Genes, Fungal; D008969:Molecular Sequence Data; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics; D017386:Sequence Homology, Amino Acid
D004271:DNA, Fungal; D014450:Electron Transport Complex III