Magnetic stimulation of axons in a nerve bundle: effects of current redistribution in the bundle.
Recently, we developed a model of magnetic stimulation of a concentric axon in an anisotropic nerve bundle. In that earlier paper, we considered a single axon surrounded by a nerve bundle represented as a homogeneous anisotropic monodomain medium. In this paper we extend our previous calculations to examine excitation of axons within a nerve bundle without neglecting the presence of other axons in the nerve bundle. A three-dimensional axial symmetry volume conductor model is used to determine the transmembrane potential response along an axon due to induced electric fields produced by a toroidal coil. Our principal objective is to examine the effect of current redistribution to other axons in the bundle on excitation characteristics. We derive the transmembrane potential along an axon for two currently available models of current redistribution: the biodomain model and the spatial--frequency monodomain model. Results indicate that a reduction in the transmembrane potential along an axon due to the presence of other nerve fibers in the bundle is observed. Axons located at the periphery of a nerve bundle have lower thresholds and different excitation sites compared with axons located near the center of a nerve bundle.
Nagarajan
S S
SS
Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106-4912, USA.
Durand
D M
DM
Roth
B J
BJ
Wijesinghe
R S
RS
D001369:Axons / Q000502:physiology*; D004558:Electric Stimulation; D004574:Electromagnetic Fields; D005583:Fourier Analysis; D008280:Magnetics; D008564:Membrane Potentials / Q000502:physiology; D008959:Models, Neurological; D009431:Neural Conduction / Q000502:physiology*