Effects of selective serotonergic agonists on aggressive behavior in rats.
The effects of the relatively specific serotonergic agonists 8-OH-DPAT (5-HT1A), TFMPP (5-HT1B), and DOB (5-HT2) were studied on defensive aggressive behavior in rats using the water competition test, 8-OH-DPAT (up to 0.25 mg/kg) and TFMPP (up to 1 mg/kg) were found to be ineffective, whereas DOB (up to 0.4 mg/kg) significantly reduced aggressive behavior in this test as well as in the offensive aggression test of the resident-intruder model. These results, combined with those from other studies, suggest that stimulation of 5-HT1A, 5-HT1B, and 5-HT2 receptors reduces offensive aggression, whereas defensive aggression is only decreased by 5-HT2 stimulation.
Muehlenkamp
F
F
Department of Pharmacology, Jefferson Medical College of Thomas Jefferson University, Philadelphia, PA 19107, USA.
Lucion
A
A
Vogel
W H
WH
D000374:Aggression / Q000187:drug effects*; D000818:Animals; D004327:Drinking Behavior / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*
D017366:Serotonin Receptor Agonists