Estimation of cerebral blood flow from thermal measurement.
A thermal method has been developed to quantify continuous perfusion changes with self-calibration. A dynamic, one-dimensional bio-heat transfer model of the thermal probe and tissue describes the system response to either continuous or transient heating. A nonlinear least-squares fit of the model to experimental data yields estimates of the baseline perfusion and other model parameters. With a partial analytical solution of the model, the optimal estimation procedure is two orders of magnitude more efficient than with a total numerical solution of the model system. Experimental data is used to estimate the operating relations between perfusion and the temperature measurement. A new procedure has also been presented to obtain the dynamic response of the system for continuous measurement of perfusion.
Wei
D
D
Department of Neurosciences, Cleveland Clinic Foundation, OH 44195-5283, USA.
Saidel
G M
GM
Jones
S C
SC
D000818:Animals; D001833:Body Temperature Regulation / Q000502:physiology*; D002138:Calibration; D002560:Cerebrovascular Circulation / Q000502:physiology*; D005069:Evaluation Studies as Topic; D016018:Least-Squares Analysis; D008991:Monitoring, Physiologic / Q000295:instrumentation; D051381:Rats; D015203:Reproducibility of Results; D013814:Thermal Conductivity; D013821:Thermometers