title: Buspirone inhibits contact hypersensitivity in the mouse.
abstract: We have observed that 8-4-[4-2-pyrimidyl)-1-piperazinyl]butyl]-8-azaspiro [4.5]decane-7.9-dione, an agent commonly known as buspirone HCl, possesses immunosuppressive activity when administered either topically or systemically, as assessed in a mouse model of contact hypersensitivity. Topical or systemic administration of buspirone significantly reduced the tissue swelling and leukocyte infiltration associated with the elicitation phase of contact hypersensitivity. Buspirone is a safe, widely used drug which has a history of use in humans throughout the world. These data demonstrate a previously unknown pharmacologic activity of buspirone.
authors.affiliation: Arcturus Pharmaceutical Corporation, Woburn, MA 01801, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: McAloon
authors.forename: A
authors.initials: A
authors.lastname: ChandraSekar
authors.forename: Y J
authors.initials: YJ
authors.lastname: Lin
authors.forename: G C
authors.initials: GC
authors.lastname: Hwang
authors.forename: R J
authors.initials: RJ
authors.lastname: Sharpe
mesh_terms: D000818:Animals; D002065:Buspirone / Q000494:pharmacology / Q000627:therapeutic use*; D017449:Dermatitis, Allergic Contact / Q000473:pathology / Q000517:prevention & control*; D004305:Dose-Response Relationship, Drug; D004353:Drug Evaluation, Preclinical; D004487:Edema / Q000139:chemically induced / Q000473:pathology / Q000517:prevention & control; D005260:Female; D007962:Leukocytes / Q000473:pathology; D051379:Mice; D008807:Mice, Inbred BALB C; D010081:Oxazolone / Q000633:toxicity; D012701:Serotonin / Q000502:physiology
chemical_list: D010081:Oxazolone; D012701:Serotonin; D002065:Buspirone