title: Paget's disease of bone: review with emphasis on radiologic features, Part I.
abstract: Distinctive clinical, radiologic and pathologic features are seen in Paget's disease of bone. These distinct features can be divided into three phases; initial phase, midphase, and late phase. The clinical features may vary from patients being asymptomatic (involving a single bone) to patients having severe, multiple bone involvement with systemic disease. Radiologically, there are unique features which can differentiate Paget's disease from other bone diseases. The radiologic features follows the histologic findings on light microscopy. The correlation of the different phases with the clinical, radiologic and pathologic features of Paget's disease allows for early accurate diagnosis and treatment.
authors.affiliation: Orthopaedic Oncology Service, Orthopaedic Hospital, Los Angeles CA, 90007, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Mirra
authors.forename: E W
authors.initials: EW
authors.lastname: Brien
authors.forename: J
authors.initials: J
authors.lastname: Tehranzadeh
mesh_terms: D000328:Adult; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000473:pathology; D003952:Diagnostic Imaging; D005260:Female; D006801:Humans; D008297:Male; D010001:Osteitis Deformans / Q000175:diagnosis* / Q000000981:diagnostic imaging / Q000473:pathology*; D010006:Osteoblasts / Q000473:pathology; D010010:Osteoclasts / Q000473:pathology; D010014:Osteolysis / Q000000981:diagnostic imaging / Q000473:pathology; D010026:Osteosclerosis / Q000000981:diagnostic imaging / Q000473:pathology; D011859:Radiography; D011877:Radionuclide Imaging