Phylogeny of lymphocyte heterogeneity: cytotoxic activity of channel catfish peripheral blood leukocytes directed against allogeneic targets.
Channel catfish peripheral blood contains leukocytes that function as cytotoxic effectors directed against a variety of long-term cultured allogeneic, but not xenogeneic, targets. These effector cells are probably distinct from macrophages, B cells, and nonspecific cytotoxic cells. The cytotoxic activity of these effector cells was inhibited with monoclonal antibody 1H5. Although this reagent appears to react with a catfish cell surface molecule akin to the integrin LFA-1 present on the surface of nearly all leukocytes, it does not clarify the question as to whether or not these effectors are related to T cells.
Yoshida
S H
SH
Department of Microbiology, University of Mississippi Medical Center, Jackson 39216, USA.
Stuge
T B
TB
Miller
N W
NW
Clem
L W
LW
D000818:Animals; D002478:Cells, Cultured; D003601:Cytotoxicity Tests, Immunologic; D007059:Ictaluridae / Q000097:blood / Q000276:immunology*; D007962:Leukocytes / Q000276:immunology*; D016131:Lymphocyte Subsets; D010802:Phylogeny; D013045:Species Specificity