Distension produces medial but not endothelial damage in porcine internal mammary artery.
The influence of intraluminal distension on porcine internal mammary artery was studied using adenosine 5'-triphosphate (ATP) concentration and prostacyclin production as biochemical markers of medial and endothelial functional integrity respectively. Distension reduced mean (95% confidence limits) tissue ATP concentrations from 459 (337-581) nmol/g wet weight to 314 (193-435) nmol/g wet weight (n = 10, P < 0.01). Stimulated prostacyclin production was similar in undistended (25.8(15.9-35.9) pg/min per mg wet weight) and distended arteries (33.2(21.4-45.1) pg/min per mg wet weight) (n = 8, not significant). The data demonstrate that distension of the internal mammary artery results in acute medial but not endothelial damage. Distension-induced medial damage is unlikely to be rapidly reversible and might have implications for the early and long-term function of the artery as a bypass graft.
Cooper
G J
GJ
Department of Cardiac Surgery, University of Sheffield, UK.
Gillot
T
T
Francis
S E
SE
Angelini
G D
GD
D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D004730:Endothelium, Vascular / Q000502:physiology; D011464:Epoprostenol / Q000096:biosynthesis; D005260:Female; D066298:In Vitro Techniques; D008323:Mammary Arteries / Q000378:metabolism / Q000502:physiology* / Q000648:ultrastructure; D008855:Microscopy, Electron, Scanning; D013552:Swine
D000255:Adenosine Triphosphate; D011464:Epoprostenol