title: Apolipoprotein B messenger RNA editing: an update.
abstract: Apolipoprotein (apo) B mRNA editing consists of a C-->U conversion of the first base of the codon CAA encoding glutamine 2153 in apoB mRNA to UAA, a stop codon. The cDNA for an apoB mRNA editing protein was recently cloned in rat and human. The human protein contains 236 amino acid residues and exists as a homodimer. The editing protein edits apoB mRNA in vitro only in the presence of tissue complementation factors. There is a leucine-rich motif spanning residues 173-210 of the protein which may be involved in homodimer formation and/or interaction with complementation factors. The requirements for these factors support the existence of an editosome involved in apoB mRNA editing.
authors.affiliation: Department of Cell Biology, Baylor College of Medicine, Houston, TX 77030, USA.
authors.forename: L
authors.initials: L
authors.lastname: Chan
mesh_terms: D000071479:APOBEC-1 Deaminase; D053299:Apolipoprotein B-100; D053283:Apolipoprotein B-48; D001055:Apolipoproteins B / Q000737:chemistry / Q000235:genetics*; D003062:Codon; D003564:Cytidine Deaminase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D008074:Lipoproteins / Q000737:chemistry; D017393:RNA Editing; D012333:RNA, Messenger / Q000378:metabolism*; D000098830:AICDA (Activation-Induced Cytidine Deaminase)
chemical_list: D053299:Apolipoprotein B-100; D053283:Apolipoprotein B-48; D001055:Apolipoproteins B; D003062:Codon; D008074:Lipoproteins; D012333:RNA, Messenger; D000098830:AICDA (Activation-Induced Cytidine Deaminase); D000071479:APOBEC-1 Deaminase; C000605089:APOBEC1 protein, human; C000605091:Apobec1 protein, rat; D003564:Cytidine Deaminase