Family segregation analysis of inheritance of human minor histocompatibility antigen.
Disparities in minor histocompatibility antigens (mHAs) between HLA-identical donor and recipient pairs often cause graft-versus-host disease (GVHD) or graft rejection. Minor HAs are thought to be peptides that are associated with specific major histocompatibility complex (MHC) molecules and are presented to specific T cells. Despite the importance of mHAs in constructing a strong immunological barrier following tissue transplantation, little information on mHAs in humans is available. We have already reported establishment of the DR9-restricted mHA-specific CD4+ cytotoxic T cell (CTL) clone "A-6." To investigate the chromosomal localization of the gene encoding the mHA peptide recognized by clone A-6 in context with DR9, we performed a family segregation analysis. We concluded that the mHA-encoding gene was transmitted from parent(s) to some offspring.
Nishimura
M
M
Department of Research, Japanese Red Cross Central Blood Center, Tokyo.
Mitsunaga
S
S
Uchikawa
C
C
Takahashi
K
K
Tokunaga
K
K
Tadokoro
K
K
Juji
T
T
D001402:B-Lymphocytes / Q000502:physiology*; D003601:Cytotoxicity Tests, Immunologic; D005260:Female; D005787:Gene Frequency; D005828:Genetics, Population; D005838:Genotype; D006680:HLA Antigens / Q000235:genetics; D006801:Humans; D008297:Male; D015778:Minor Histocompatibility Antigens / Q000235:genetics*; D008957:Models, Genetic; D010375:Pedigree; D010641:Phenotype
D006680:HLA Antigens; D015778:Minor Histocompatibility Antigens