title: Catastrophic secondary antiphospholipid syndrome with concomitant antithrombin III deficiency.
abstract: The association between thrombotic events and primary or secondary antiphospholipid/anticardiolipin syndrome is now well recognized. A spectrum of renal involvement ranging from glomerular thrombosis to renal infarction has been described. A case of systemic lupus erythematosus with immunoglobulin G and M antiphospholipid/anticardiolipin antibodies is reported. The patient developed catastrophic thrombosis in multiple organs, and glomerular thrombosis was documented by renal biopsy. The patient had an acquired antithrombin III deficiency, and the combination of secondary antiphospholipid syndrome with accompanying antithrombin III deficiency predisposed to thrombosis. Several mechanisms by which antiphospholipid/anticardiolipin antibodies cause thrombosis have been proposed and are briefly reviewed.
authors.affiliation: Department of Internal Medicine, University of Cincinnati Medical Center, OH, USA.
authors.forename: V R
authors.initials: VR
authors.lastname: Peddi
authors.forename: K S
authors.initials: KS
authors.lastname: Kant
mesh_terms: D000328:Adult; D017153:Antibodies, Anticardiolipin / Q000032:analysis; D017152:Antibodies, Antiphospholipid / Q000032:analysis; D016736:Antiphospholipid Syndrome / Q000150:complications* / Q000503:physiopathology; D020152:Antithrombin III Deficiency; D006801:Humans; D007674:Kidney Diseases / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D007678:Kidney Glomerulus / Q000473:pathology; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D013927:Thrombosis / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology
chemical_list: D017153:Antibodies, Anticardiolipin; D017152:Antibodies, Antiphospholipid