Lingual hyperpigmentation associated with minocycline therapy.
Minocycline can cause hyperpigmentation of the conjunctiva, oral mucosa, and skin. Pigmentation of the oral mucosa may also be associated with a variety of endogenous or exogenous factors. Lingual pigmentation may be seen in Addison's disease, amalgam tatoo, malignant melanoma, Peutz-Jegher's syndrome, and other diseases. Two women who had isolated pigmentation of the tongue while taking minocycline are described; no other drug-induced pigmentation of their oral mucosa or skin occurred. Minocycline-induced pigmentation should be added to the differential diagnosis of isolated lingual hyperpigmentation.
Meyerson
M A
MA
Department of Dermatology, University of Texas-Houston Medical School, USA.
Cohen
P R
PR
Hymes
S R
SR
D000152:Acne Vulgaris / Q000188:drug therapy; D000328:Adult; D005260:Female; D006801:Humans; D017495:Hyperpigmentation / Q000139:chemically induced*; D008875:Middle Aged; D008911:Minocycline / Q000009:adverse effects*; D009061:Mouth Mucosa / Q000187:drug effects; D012393:Rosacea / Q000188:drug therapy; D014060:Tongue Diseases / Q000139:chemically induced*
D008911:Minocycline