Within-subject decline in delayed-non-match-to-sample radial arm maze performance in aging Sprague-Dawley rats.
A within-subject design was used to examine delayed-non-match-to-sample radial arm maze performance in aging (6-18 months) male Sprague-Dawley rats. A decrease in correct choices and an increase in retroactive errors were observed at all retention intervals at 18 months of age compared with performance at 6 or 12 months. No age by retention interval interaction was observed. Neither age nor increasing retention interval influenced proactive errors during the retention test. The observation of an age- and delay-dependent increase in retroactive errors, but not proactive errors, suggests that the deficit relates to a memory dysfunction as opposed to a generalized performance deficit.
Chrobak
J J
JJ
Department of Pharmacology and Experimental Therapeutics, Stritch School of Medicine, Loyola University of Chicago, USA.
Hanin
I
I
Lorens
S A
SA
Napier
T C
TC
D000375:Aging / Q000523:psychology*; D000818:Animals; D002755:Choice Behavior; D004193:Discrimination Learning; D007266:Inhibition, Psychological; D008297:Male; D018782:Maze Learning; D011939:Mental Recall; D051381:Rats; D017207:Rats, Sprague-Dawley; D011930:Reaction Time; D012153:Retention, Psychology