title: Is rotavirus a population of reassortants?
abstract: Rotaviruses appear to exist as heterogeneous populations of reassortants and related variants. This phenomenon is consistent with the quasispecies concept of RNA viruses, and suggests that gene reassortment is a crucial evolutionary mechanism for this segmented virus. It also explains puzzling epidemiological findings and controversial results of vaccine-efficacy studies.
authors.affiliation: Human Genetics Branch, National Institutes of Health, Bethesda, MD 20892, USA.
authors.forename: V
authors.initials: V
authors.lastname: Gouvea
authors.forename: M
authors.initials: M
authors.lastname: Brantly
mesh_terms: D000818:Animals; D005075:Biological Evolution; D006801:Humans; D016865:Reassortant Viruses; D012401:Rotavirus / Q000235:genetics; D014765:Viral Vaccines
chemical_list: D014765:Viral Vaccines