1,3-Diphenylpropane-1,3-diamines, VI): DNA-interaction, estrogen receptor affinity, and cytostatic activity of 1,3-diphenylpropane-1,3-diamine-Pt(II) complexes.
The Pt(II) complexes of 1,3-diphenylpropane-1,3-diamines (part IV2)) were tested for DNA interaction (UV-difference spectroscopy, Tables 1 and 2), for affinity to the estrogen receptor (calf uterus cytosol; scarcely any affinity), and for cytostatic activity at estrogen independent MDA-MB 231 cells (Tables 3 and 4) and estrogen dependent MCF-7 cells (Tables 5 and 6). The data are compared with those reported for the analogous 1,2-diphenylethane-1,2-diamine-Pt(II) complexes: most probably, the cytostatic activity is not mediated by the estrogen receptor.
Kammermeier
T
T
Institute of Pharmacy, University, Regensburg, Germany.
Wiegrebe
W
W
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002417:Cattle; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D051379:Mice; D009944:Organoplatinum Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D011960:Receptors, Estrogen / Q000187:drug effects*; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D009944:Organoplatinum Compounds; D011960:Receptors, Estrogen; D004247:DNA