P2-purinergic receptors: subtype-associated signaling responses and structure.
Extracellular adenine nucleotides interact with P2-purinergic receptors to regulate a broad range of physiological processes. These receptors include the P2Y-, P2U-, P2T-, P2X-, and P2Z-purinergic receptor subtypes. This review focuses on the first three of these receptor subtypes, which couple to G proteins and regulate the inositol lipid, cyclic AMP, and other second-messenger signaling cascades. Both pharmacological data and the occurrence of selectivity of coupling to second-messenger pathways indicate the existence of multiple members in several of the classes of P2-purinergic receptor subtypes. Complementary DNAs cloned for P2Y- and P2U-purinergic receptors predict proteins with seven transmembrane-spanning motifs, typical of that of other G protein-linked receptors.
Harden
T K
TK
Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill 27599, USA.
Boyer
J L
JL
Nicholas
R A
RA
D000227:Adenine Nucleotides / Q000378:metabolism; D000595:Amino Acid Sequence; D000818:Animals; D000242:Cyclic AMP / Q000378:metabolism; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D007294:Inositol / Q000378:metabolism; D008969:Molecular Sequence Data; D058910:Purinergic P2 Receptor Agonists; D011869:Radioligand Assay; D018048:Receptors, Purinergic P2 / Q000737:chemistry / Q000145:classification / Q000378:metabolism*; D015290:Second Messenger Systems; D013329:Structure-Activity Relationship
D000227:Adenine Nucleotides; D058910:Purinergic P2 Receptor Agonists; D018048:Receptors, Purinergic P2; D007294:Inositol; D000242:Cyclic AMP; D019204:GTP-Binding Proteins