[The ethanol elimination pharmacokinetics--the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism].
The effect of CYP2E1 upon the blood ethanol level was investigated. Blood ethanol concentrations in 4 volunteers whose ADH 2, ADH 3 and ALDH 2 genotypes were identical, were determined after intravenous administrations of 0.20 g/kg of ethanol by gas chromatography. The predicting 95% confidence bounds determined on regression analysis of these data suggested that after venous injection of ethanol, the blood ethanol concentration in a volunteer normal homozygous for CYP2E1 (C1/C1) is higher than that heterozygous (C1/C2). And beta 60 (the blood ethanol concentration-time curve) of the subject heterozygous for CYP2E1 (C1/C2) was higher than that normal homozygous (C1/C1). It is possible that the C2 allele corresponding to the higher CYP2E1 activity may affect the ethanol metabolism.
Iwahashi
K
K
Department of Neuropsychiatry, Kagawa Medical School, Japan.
Miyatake
R
R
Nakamura
K
K
Suwaki
H
H
Kinoshita
H
H
Ameno
K
K
Ijiri
I
I
Ishikawa
Y
Y
Yoneyama
H
H
Mendori
T
T
D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D000431:Ethanol / Q000493:pharmacokinetics*; D005838:Genotype; D006801:Humans
D000431:Ethanol; D003577:Cytochrome P-450 Enzyme System; D000444:Aldehyde Dehydrogenase