Pathology of the liver in leukaemia and lymphoma. A study of 110 autopsies.
Histopathological findings in the liver in a series of autopsies on 110 patients suffering from leukaemia or lymphoma were reviewed. No treatment had been given to 23 patients, 50 had received chemotherapy alone, 23 chemo- and radiotherapy and 14 underwent bone marrow transplantation. The 23 untreated patients showed neoplastic infiltration in 10 (44%) and fibrosis in 16 cases (70%). The 14 bone marrow recipients showed mainly acute necrosis, zonal in six (43%) and focal in one (7%), and cholestasis in five (36%), together with marked siderosis in 11 (79%). Patients receiving chemotherapy or chemo-/radiotherapy showed similar changes consisting of neoplastic infiltration in 14 (28%) and in five (22%) cases respectively, and fibrosis in 31 (62%) and 17 (74%) cases respectively. Steatosis was seen in 70% of cases in the chemo-/radiotherapy group and in 50% of cases in the other groups. Infections were seen in all groups, particularly in the chemotherapy group (four fungal and two bacterial including one tuberculosis) and in the chemo-/radiotherapy group (one fungal and one bacterial). Cytomegalovirus infection was seen only in the bone marrow transplant group.
Scheimberg
I B
IB
Department of Histopathology, Royal London Hospital, UK.
Pollock
D J
DJ
Collins
P W
PW
Doran
H M
HM
Newland
A C
AC
van der Walt
J D
JD
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000682:Amyloid / Q000032:analysis; D016026:Bone Marrow Transplantation / Q000009:adverse effects; D002779:Cholestasis / Q000473:pathology; D004692:Endarteritis / Q000473:pathology; D005260:Female; D006504:Hepatic Veno-Occlusive Disease / Q000473:pathology; D006529:Hepatomegaly / Q000473:pathology; D006801:Humans; D007938:Leukemia / Q000150:complications / Q000473:pathology* / Q000628:therapy; D008099:Liver / Q000473:pathology*; D008107:Liver Diseases / Q000150:complications / Q000473:pathology*; D008223:Lymphoma / Q000150:complications / Q000473:pathology* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D009336:Necrosis / Q000473:pathology; D012806:Siderosis / Q000473:pathology
D000682:Amyloid