title: No detrimental effect of fibrin glue on the regeneration of intrabony defects. A controlled clinical trial.
abstract: This controlled clinical trial evaluated the potential of fibrin glue as a biological carrier to locally deliver guided tissue regeneration (GTR) modulators, 2 controlateral, morphologically similar defects were selected in each of 11 patients and randomly assigned to the test (teflon membrane and fibrin glue) and the control treatment (teflon membrane alone). Outcomes were assessed at membrane removal as newly formed granulation tissue and at the 1-year follow-up in terms of changes in probing attachment level, probing pocket depth, recession of the gingival margin, probing bone levels and percentage of fill of the intrabony defects. Data confirmed that GTR treatment of deep intrabony defects results in clinically and statistically significant improvements of the clinical parameters. No significant differences, however, were evidenced between the test and the control treatments. It is suggested that, since fibrin glue did not show detrimental effects on GTR, it could be applied as a biological carrier for the delivery of GTR enhancers into the surgical wound.
authors.affiliation: Department of Periodontology, School of Dental Medicine, University of Siena, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Cortellini
authors.forename: G P
authors.initials: GP
authors.lastname: Pini Prato
authors.forename: M S
authors.initials: MS
authors.lastname: Tonetti
mesh_terms: D000328:Adult; D000539:Alveolar Process / Q000473:pathology; D005260:Female; D015718:Fibrin Tissue Adhesive / Q000627:therapeutic use*; D005500:Follow-Up Studies; D017823:Furcation Defects / Q000473:pathology / Q000601:surgery*; D005889:Gingival Recession / Q000473:pathology / Q000601:surgery; D006097:Granulation Tissue / Q000473:pathology; D016557:Guided Tissue Regeneration, Periodontal; D006801:Humans; D008297:Male; D008567:Membranes, Artificial; D008875:Middle Aged; D017622:Periodontal Attachment Loss / Q000473:pathology / Q000601:surgery; D010514:Periodontal Pocket / Q000473:pathology / Q000601:surgery; D011138:Polytetrafluoroethylene; D011446:Prospective Studies; D012038:Regeneration; D014014:Tissue Adhesives / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D015718:Fibrin Tissue Adhesive; D008567:Membranes, Artificial; D014014:Tissue Adhesives; D011138:Polytetrafluoroethylene