title: The genes encoding the biotin carboxyl carrier protein and biotin carboxylase subunits of Bacillus subtilis acetyl coenzyme A carboxylase, the first enzyme of fatty acid synthesis.
abstract: The genes encoding two subunits of acetyl coenzyme A carboxylase, biotin carboxyl carrier protein, and biotin carboxylase have been cloned from Bacillus subtilis. DNA sequencing and RNA blot hybridization studies indicated that the B. subtilis accB homolog which encodes biotin carboxyl carrier protein, is part of an operon that includes accC, the gene encoding the biotin carboxylase subunit of acetyl coenzyme A carboxylase.
authors.affiliation: Departamento de Microbiología, Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Argentina.
authors.forename: P
authors.initials: P
authors.lastname: Marini
authors.forename: S J
authors.initials: SJ
authors.lastname: Li
authors.forename: D
authors.initials: D
authors.lastname: Gardiol
authors.forename: J E
authors.initials: JE
authors.lastname: Cronan
authors.forename: D
authors.initials: D
authors.lastname: de Mendoza
mesh_terms: D000103:Acetyl-CoA Carboxylase / Q000235:genetics*; D000595:Amino Acid Sequence; D001412:Bacillus subtilis / Q000201:enzymology / Q000235:genetics*; D001426:Bacterial Proteins / Q000032:analysis; D001483:Base Sequence; D001710:Biotin / Q000032:analysis; D019731:Carbon-Nitrogen Ligases; D002352:Carrier Proteins / Q000235:genetics*; D003001:Cloning, Molecular; D004926:Escherichia coli / Q000235:genetics; D054889:Fatty Acid Synthase, Type II; D005227:Fatty Acids / Q000096:biosynthesis; D005798:Genes, Bacterial; D005816:Genetic Complementation Test; D008025:Ligases / Q000235:genetics*; D008969:Molecular Sequence Data; D017421:Sequence Analysis; D014158:Transcription, Genetic
chemical_list: D001426:Bacterial Proteins; D002352:Carrier Proteins; D005227:Fatty Acids; D001710:Biotin; D054889:Fatty Acid Synthase, Type II; D008025:Ligases; D019731:Carbon-Nitrogen Ligases; C019791:biotin carboxylase; D000103:Acetyl-CoA Carboxylase; C079633:biotin carboxyl carrier protein