Integrin expression in head and neck cancers.
Neoplastic transformation results in rearrangement of the cell membrane with a breakdown of the regular expression of adhesion molecules such as integrins. A relationship may exist between the intensity of this alteration, and the form it takes, and a tumour's ability to metastatise. We studied this possibility by investigating the epithelial integrin expression of 35 head and neck squamous cell carcinomas. Two types of positivity were observed: one associated with tumours with a better prognostic index, the other with those characterized by greater malignancy.
Cortesina
G
G
II ENT Department, University of Torino, Italy.
Sacchi
M
M
Bussi
M
M
Panizzut
B
B
Ferro
S
S
Carlevato
M T
MT
Marchisio
P C
PC
D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D015815:Cell Adhesion Molecules / Q000032:analysis; D046508:Culture Techniques; D004848:Epithelium / Q000737:chemistry / Q000473:pathology / Q000648:ultrastructure; D006801:Humans; D016023:Integrins / Q000032:analysis*; D007797:Laminin / Q000032:analysis; D007822:Laryngeal Neoplasms / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D007830:Larynx / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D009367:Neoplasm Staging; D009959:Oropharyngeal Neoplasms / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D009960:Oropharynx / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D011379:Prognosis; D017474:Receptors, Laminin; D000097794:Kalinin
D015815:Cell Adhesion Molecules; D016023:Integrins; D007797:Laminin; D017474:Receptors, Laminin; D000097794:Kalinin