Graft-induced reduction in [3H]dopamine uptake into the non-lesioned striatum.
The effect of intraventricular fetal mesencephalic grafts placed in the 6-hydroxydopamine (6-OHDA) lesioned striatum on [3H]dopamine (DA) uptake into synaptosomes was studied. Apomorphine (APO)- and amphetamine (AMPH)-induced rotational behaviour was continuously reduced by the grafts over 7 months. After this time, a non-significant increase in [3H]DA uptake into synaptosomes of the lesioned striatum and an approximately 40% decrease in [3H]DA uptake into synaptosomes of the non-lesioned striatum were found. Grafts placed in the non-lesioned striatum did not significantly change both rotational behaviour or [3H]DA uptake. The results show that unilateral fetal mesencephalic grafts producing behavioural improvement in the unilateral 6-OHDA lesioned rat induce changes in dopaminergic structures in the non-lesioned striatum.
Schäfer
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Institute of Pharmacology and Toxicology, Medical Faculty (Charité), Humboldt University, Berlin, Germany.
Reum
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Morgenstern
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R
D000661:Amphetamine / Q000494:pharmacology; D000704:Analysis of Variance; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D003342:Corpus Striatum / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism*; D016332:Fetal Tissue Transplantation / Q000502:physiology*; D008297:Male; D008636:Mesencephalon / Q000637:transplantation*; D009043:Motor Activity / Q000187:drug effects; D016627:Oxidopamine; D051381:Rats; D017208:Rats, Wistar; D012399:Rotation; D013574:Synaptosomes / Q000378:metabolism*; D014316:Tritium
D014316:Tritium; D016627:Oxidopamine; D000661:Amphetamine; D001058:Apomorphine; D004298:Dopamine