title: Effect of chronic respiratory acidosis on calcium metabolism in the rat.
abstract: Chronic metabolic acidosis typically results in hypercalciuria and negative calcium balance. The impact of chronic respiratory acidosis on calcium metabolism has been less well studied. To address this issue, metabolic balance and static bone histomorphometric data were obtained during a 14-day exposure of rats to 10% CO2 (blood pH 7.33, PaCO2 83 mm Hg) and were compared with pair-fed controls. All rats were fed a 0.8% calcium diet. Urinary calcium excretion (mg/period, mean +/- SEM) was increased during both week 1 and week 2 (16 +/- 3 vs 9 +/- 1 and 16 +/- 2 vs 9 +/- 1, CO2 group vs controls, respectively [p < 0.05]). Net intestinal calcium absorption (intake minus fecal excretion) was increased throughout the period of hypercapnia (week 1, 213 +/- 19 mg vs 135 +/- 15 mg; week 2, 135 +/- 16 mg vs 43 +/- 14 mg; and cumulatively, 344 +/- 27 mg vs 178 +/- 20 mg, CO2 group vs controls [p < 0.01]). As a consequence of the marked increment in intestinal calcium absorption during hypercapnia, mean net calcium balance was more positive than that of controls throughout the study (week 1, 197 +/- 18 mg vs 126 +/- 15 mg; week 2, 120 +/- 15 mg vs 34 +/- 15 mg; and cumulatively, 317 +/- 25 mg vs 159 +/- 20 mg, CO2 group vs controls, respectively [p < 0.01]). There were no significant differences in calcium intake, plasma total calcium, immunoreactive parathyroid hormone, 25-hydroxyvitamin D, or creatinine clearance between the two groups.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, Tufts University School of Medicine, Boston, MA, USA.
authors.forename: V J
authors.initials: VJ
authors.lastname: Canzanello
authors.forename: J A
authors.initials: JA
authors.lastname: Kraut
authors.forename: M F
authors.initials: MF
authors.lastname: Holick
authors.forename: C
authors.initials: C
authors.lastname: Johns
authors.forename: C C
authors.initials: CC
authors.lastname: Liu
authors.forename: N E
authors.initials: NE
authors.lastname: Madias
mesh_terms: D000142:Acidosis, Respiratory / Q000378:metabolism*; D000818:Animals; D001862:Bone Resorption; D001842:Bone and Bones / Q000473:pathology; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D002118:Calcium / Q000008:administration & dosage / Q000378:metabolism* / Q000652:urine; D002908:Chronic Disease; D004032:Diet; D005243:Feces / Q000737:chemistry; D007408:Intestinal Absorption; D008297:Male; D010281:Parathyroid Hormone / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D010281:Parathyroid Hormone; D002117:Calcitriol; D002112:Calcifediol; D002118:Calcium