title: LFER and CoMFA studies on optical resolution of alpha-alkyl alpha-aryloxy acetic acid methyl esters on DACH-DNB chiral stationary phase.
abstract: The HPLC resolution of a series of racemic alpha-substituted alpha-aryloxy acetic acid methyl esters I on a pi-acid N,N'-(3,5-dinitrobenzoyl)-trans-1,2-diaminocyclohexane as chiral selector was modelled by linear free energy-related (LFER) equations and comparative molecular field analysis (CoMFA). Our results indicate that the retention process mainly depends on solute lipophilicity and steric properties, whereas enantioselectivity is primarily influenced by electrostatic and steric interactions. CoMFA provided additional information with respect to the LFER study, allowed the mixing of different subsets of I and led to a quantitative 3D model of steric and electrostatic factors responsible for chiral recognition.
authors.affiliation: Dipartimento Farmacochimico, Università degli Studi di Bari, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Carotti
authors.forename: C
authors.initials: C
authors.lastname: Altomare
authors.forename: S
authors.initials: S
authors.lastname: Cellamare
authors.forename: A
authors.initials: A
authors.lastname: Monforte
authors.forename: G
authors.initials: G
authors.lastname: Bettoni
authors.forename: F
authors.initials: F
authors.lastname: Loiodice
authors.forename: N
authors.initials: N
authors.lastname: Tangari
authors.forename: V
authors.initials: V
authors.lastname: Tortorella
mesh_terms: D000085:Acetates / Q000737:chemistry* / Q000302:isolation & purification; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D003514:Cyclohexylamines; D004952:Esters / Q000737:chemistry / Q000302:isolation & purification; D008958:Models, Molecular; D008968:Molecular Conformation; D015394:Molecular Structure; D009579:Nitrobenzoates; D010647:Phenyl Ethers / Q000737:chemistry* / Q000302:isolation & purification; D011422:Propionates / Q000737:chemistry* / Q000302:isolation & purification; D012984:Software; D013237:Stereoisomerism
chemical_list: D000085:Acetates; D003514:Cyclohexylamines; D004952:Esters; D009579:Nitrobenzoates; D010647:Phenyl Ethers; D011422:Propionates; C094607:N,N'-(3,5-dinitrobenzoyl)-1,2-diaminocyclohexane