title: Stability of a 1 beta-methylcarbapenem antibiotic, meropenem (SM-7338) in aqueous solution.
abstract: The stability and the degradation products of 1 beta-methylcarbapenem, meropenem in aqueous solution were investigated. In pH 4-8 dilute solution, pseudo-first-order degradation was observed, and good stability of meropenem in aqueous solution was demonstrated by the effect of 1 beta-methyl group against hydrolysis of beta-lactam ring. As degradation products, the beta-lactam hydrolyzed product and the dimer product resulting from intermolecular aminolysis of beta-lactam ring by the amine of the second molecule were described.
authors.affiliation: Research Center Sumitomo Pharmaceuticals Co., Ltd., Osaka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Takeuchi
authors.forename: M
authors.initials: M
authors.lastname: Sunagawa
authors.forename: Y
authors.initials: Y
authors.lastname: Isobe
authors.forename: Y
authors.initials: Y
authors.lastname: Hamazume
authors.forename: T
authors.initials: T
authors.lastname: Noguchi
mesh_terms: D000890:Anti-Infective Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D007700:Kinetics; D000077731:Meropenem; D012996:Solutions; D013845:Thienamycins / Q000737:chemistry*; D014867:Water
chemical_list: D000890:Anti-Infective Agents; D012996:Solutions; D013845:Thienamycins; D014867:Water; D000077731:Meropenem