title: Functional improvement with vitamin D replenishment in a cohort of frail, vitamin D-deficient older people.
abstract: OBJECTIVE
  To evaluate functional improvement in a population of frail, homebound older persons with low vitamin D status as vitamin D stores improve.
  
  
  METHODS
  Randomized, controlled intervention study.
  
  
  METHODS
  Subjects' homes and a nursing facility in Baltimore, Maryland.
  
  
  METHODS
  The first 32 subjects (community-dwelling, homebound older subjects from the Johns Hopkins Elder Housecall Program and nursing home residents from the Johns Hopkins Geriatrics Center) entered in a longitudinal study of vitamin D replacement.
  
  
  METHODS
  Baseline 25-hydroxyvitamin D levels were measured and repeated at least 1 month after therapy with either placebo or vitamin D (ergocalciferol). Subjects were also administered the Frail Elderly Functional Assessment (FEFA) questionnaire, an instrument demonstrated to be reliable, valid, and sensitive to small increments of functional change in this population.
  
  
  RESULTS
  All subjects started with 25-hydroxyvitamin D levels less than 15 ng/mL. Those subjects whose levels improved by at least 3 ng/mL (> assay coefficient of variation) also demonstrated improvement in FEFA score. Regression analysis between change in FEFA score compared with change in 25-hydroxyvitamin D was significant (r = .4; P = .02).
  
  
  CONCLUSIONS
  In this cohort of homebound older people, improvement in vitamin D status was associated with functional improvement as measured by the FEFA questionnaire.
authors.affiliation: Department of Medicine, Union Memorial Hospital, Baltimore, MD 21218, USA.
authors.forename: F M
authors.initials: FM
authors.lastname: Gloth
authors.forename: C E
authors.initials: CE
authors.lastname: Smith
authors.forename: B W
authors.initials: BW
authors.lastname: Hollis
authors.forename: J D
authors.initials: JD
authors.lastname: Tobin
mesh_terms: D000368:Aged; D004872:Ergocalciferols / Q000097:blood / Q000627:therapeutic use*; D016330:Frail Elderly; D015577:Geriatric Assessment; D006801:Humans; D008137:Longitudinal Studies; D011863:Radioimmunoassay; D012044:Regression Analysis; D011795:Surveys and Questionnaires; D016896:Treatment Outcome; D014808:Vitamin D Deficiency / Q000188:drug therapy*
chemical_list: D004872:Ergocalciferols