Characteristics of the somatotropic axis in insulin dependent diabetes mellitus.
Growth hormone (GH) plays an important role in glucose homeostasis in both healthy subjects and patients with diabetes. Patients with poorly controlled insulin-dependent diabetes mellitus (IDDM) have high basal and integrated serum GH concentrations, as well as an enhanced GH response to several secretagogues. Yet, these patients have impaired generation of insulin-like growth factor-I (IGF-I). These abnormalities tend to return to normal as an adequate metabolic control is achieved. In view of this hormonal profile, IDDM has been considered a state of relative GH resistance. Studies in experimental animals with streptozotocin-induced diabetes have shown a decreased binding of radiolabeled GH to liver membranes. More recently, adults and children with IDDM have been found to have low levels of the high affinity growth hormone binding protein (GHBP), which represents the extracellular portion of the GH receptor, and is thought to reflect GH receptor tissue concentrations. The abnormalities in the GH/IGF-I axis have been implicated in the worsening of metabolic control that occurs in some patients, as well as in the development of microvascular complications, particularly retinopathy.
Mercado
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M
Unidad de Investigación en Enfermedades Endócrinas, Hospital de Especialidades Bernardo Sepúlveda, México, D.F.
Baumann
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G
D000328:Adult; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002352:Carrier Proteins / Q000378:metabolism; D002648:Child; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology; D003922:Diabetes Mellitus, Type 1 / Q000503:physiopathology*; D003925:Diabetic Angiopathies / Q000503:physiopathology; D013006:Growth Hormone / Q000502:physiology*; D006706:Homeostasis; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000172:deficiency / Q000502:physiology; D011986:Receptors, Somatotropin / Q000172:deficiency / Q000378:metabolism; D012636:Secretory Rate / Q000187:drug effects; D013311:Streptozocin
D001786:Blood Glucose; D002352:Carrier Proteins; D011986:Receptors, Somatotropin; D013311:Streptozocin; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; C051815:somatotropin-binding protein