Evaluation of the OECD 421 reproductive toxicity screening test protocol using butyl benzyl phthalate.
The OECD421 reproductive toxicity screening test protocol was evaluated using the reproductive and developmental toxicant butyl benzyl phthalate (BBP). Female rats were orally exposed from 14 days premating to 6 days postpartum. Male rats were exposed for 29 days. At 1000 mg/kg bw/day effects were found on body weight gain and food consumption, on spermatogenesis, time to conception, pregnancy rate, postimplantation survival, and litter size and weight. Food consumption and pup weight were slightly affected at 500 mg/kg also. Effects occurred at expected dosages on the basis of literature data. These findings support the conclusion that the OECD421 test scores BBP correctly as a reproductive toxicant, both in a qualitative and in a quantitative sense.
Piersma
A H
AH
Unit Teratology, Endocrinology and Perinatal Screening, National Institute for Public Health and Environmental Protection, Bilthoven, The Netherlands.
Verhoef
A
A
Dortant
P M
PM
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004435:Eating / Q000187:drug effects; D005069:Evaluation Studies as Topic; D005260:Female; D005298:Fertility / Q000187:drug effects; D007390:International Agencies; D007391:International Cooperation; D008297:Male; D010795:Phthalic Acids / Q000633:toxicity*; D011247:Pregnancy; D051381:Rats; D012098:Reproduction / Q000187:drug effects*; D018675:Toxicity Tests
D010795:Phthalic Acids; C027561:butylbenzyl phthalate