Reducing effect of 3,4',5-trihydroxystibene-3-beta-mono-D-glucoside on arterial thrombosis induced by vascular endothelial injury.
OBJECTIVE
To study the effect of 3,4',5-trihydroxystibene-3-beta-mono-D-glucoside (Polydatin, Pol) on rabbit arterial thrombosis.


METHODS
Rabbit arterial thrombosis was induced by vascular endothelial damage with trypsin.


RESULTS
It was showed that the moist weights of the thrombus were 6.6 +/- 1.8 and 4.8 +/- 1.6 mg in Pol 5 and 10 mg.kg-1 groups, respectively, which was lighter than that in control (10.9 +/- 1.9 mg, P < 0.05, P < 0.01); the platelet aggregation was inhibited simultaneously. In vitro, Pol 0.30-1.15 mmol.L-1 reduced TXA2 produced in platelets. It did not affect the production of PGI2 in cultured human umbilical vein endothelial cells.


CONCLUSIONS
Thrombosis was abated by Pol. The selective inhibition of production of TXA2 rather than PGI2, is one of the mechanisms involved.
Wang
Y Z
YZ
Department of Pharmacology, First Military Medical University, Guangzhou, China.
Luo
S F
SF
Zhang
P W
PW
Yu
C L
CL
D000818:Animals; D002341:Carotid Artery Thrombosis / Q000517:prevention & control*; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D005960:Glucosides / Q000627:therapeutic use*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011817:Rabbits; D013267:Stilbenes / Q000627:therapeutic use*; D013929:Thromboxane B2 / Q000096:biosynthesis
D005960:Glucosides; D010975:Platelet Aggregation Inhibitors; D013267:Stilbenes; D013929:Thromboxane B2; C058229:polydatin