Neural activity and meal-associated drinking in rats.
Rats were allowed to eat a meal (chow or cracker) of approximately normal spontaneous size either with or without water available. They were then sacrificed for measurement of either plasma renin activity (PRA) and gut contents at the end of the meal or Fos-immunoreactivity (FLI) in brain 1 h after the meal. PRA was doubled at the end of the meal relative to unfed controls, and this coincided with translocation of fluid into the gut. The supraoptic and magnocellular paraventricular nuclei showed meal-related FLI. The intensity of the FLI was related to meal size, and was less prominent in rats eating moist food. This study shows that normal-sized meals produce detectable changes in fluid parameters and activate brain locations known to be related to primary stimuli of drinking.
Rowland
N E
NE
Department of Psychology, University of Florida, Gainesville 32611-2250, USA.
D000804:Angiotensin II / Q000097:blood; D000818:Animals; D004326:Drinking / Q000502:physiology*; D004435:Eating / Q000502:physiology*; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D015870:Gene Expression / Q000502:physiology; D016762:Genes, fos; D008297:Male; D009474:Neurons / Q000502:physiology*; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012083:Renin / Q000097:blood; D013495:Supraoptic Nucleus / Q000166:cytology / Q000502:physiology
D000804:Angiotensin II; D012083:Renin