title: [Substituted imidazolidinediones and thiazolidinediones: synthesis, structure and cytotoxic activity].
abstract: Synthesis and physico-chemical properties of nine 3-(4-fluoro or chlorobenzyl)-5-arylidène-imidazolidine-2,4-diones, four 3-(4-fluoro or bromobenzyl)-5-arylidène-thiazolidine-2,4-diones and three 3-)4-bromophénacyl)-5-arylidène-thiazolidine-2,4- diones has been described. These compounds were synthesized by aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted imidazolidine-2,4-diones or thiazolidine-2,4-diones. In vitro cytotoxic activity was determined for compounds 8, 17, 18, 21 and 22.
authors.affiliation: Departamento de Antibioticos, Universidade Federal de Pernambuco, Brésil.
authors.forename: D L
authors.initials: DL
authors.lastname: Barros Costa
authors.forename: J
authors.initials: J
authors.lastname: Chantegrel
authors.forename: M C
authors.initials: MC
authors.lastname: Alves de Lima
authors.forename: J M
authors.initials: JM
authors.lastname: Cavalcanti Albuquerque
authors.forename: R M
authors.initials: RM
authors.lastname: Correa Lima
authors.forename: S L
authors.initials: SL
authors.lastname: Galdino
authors.forename: I R
authors.initials: IR
authors.lastname: Pitta
authors.forename: C
authors.initials: C
authors.lastname: Luu-Duc
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007624:KB Cells; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000970:Antineoplastic Agents; D007093:Imidazoles; D013844:Thiazoles