title: Malignant germ cell tumors of the ovary: a study of 20 cases.
abstract: In a study of 20 patients diagnosed with malignant ovarian germ cell tumors between 1961 and 1993, clinical and pathologic findings were evaluated. Of the 20 patients, seven (35%) had dysgerminoma, two (10%) endodermal sinus tumor, three (15%) malignant teratoma, one (5%) malignant struma ovarii, one (5%) primary ovarian carcinoid, two (10%) benign teratoma with malignant transformation, and four (20%) combination germ cell tumor. Twelve patients (60%) had stage IA, five (25%) stage IC, and three (15%) stage IIIC. Twelve patients (60%) underwent conservative surgery and eight (40%) had at least bilateral salpingo-oophorectomy. At follow-up, 18 patients (90%) were alive free of disease, one (5%) had died of disease, and one (5%) had died of intercurrent disease. The actuarial 5-year survival rate was 93.3%. It is concluded that for young women who wish to preserve child-bearing capacity, regardless of the stage of the tumor, fertility-preserving surgery with complete surgical staging followed, if necessary by cisplatin-based combination chemotherapy is an appropriate and definitive treatment in the absence of involvement of the contralateral ovary and uterus. For patients in whom child-bearing capacity is not an issue, surgery should include total abdominal hysterectomy and bilateral salpingo-oophorectomy with complete staging, followed if necessary by chemotherapy.
authors.affiliation: Department of Obstetrics and Gynecology, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
authors.forename: B
authors.initials: B
authors.lastname: Piura
authors.forename: R
authors.initials: R
authors.lastname: Dgani
authors.forename: Y
authors.initials: Y
authors.lastname: Zalel
authors.forename: D
authors.initials: D
authors.lastname: Nemet
authors.forename: I
authors.initials: I
authors.lastname: Yanai-Inbar
authors.forename: Y
authors.initials: Y
authors.lastname: Cohen
authors.forename: M
authors.initials: M
authors.lastname: Glezerman
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002276:Carcinoid Tumor / Q000188:drug therapy / Q000601:surgery; D017024:Chemotherapy, Adjuvant; D002648:Child; D002945:Cisplatin / Q000008:administration & dosage; D004407:Dysgerminoma / Q000188:drug therapy / Q000601:surgery; D005260:Female; D018237:Germinoma / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000401:mortality / Q000601:surgery*; D010052:Ovariectomy; D012189:Retrospective Studies; D013330:Struma Ovarii / Q000188:drug therapy / Q000601:surgery; D015996:Survival Rate; D013724:Teratoma / Q000188:drug therapy / Q000601:surgery
chemical_list: D002945:Cisplatin