title: Ambient, biological, and biological effect monitoring of exposure to polycyclic aromatic hydrocarbons (PAHs).
abstract: A novel strategy was utilised to assess the risk to health from exposure to polycyclic aromatic hydrocarbons (PAHs). Ambient monitoring was carried out by personal sampling. Urinary thioethers (UTh) and urinary 1-hydroxypyrene (1-HP) were utilised for biological monitoring. Urinary d-glucaric acid (UDGA) and sister chromatid exchange (SCE) in peripheral blood lymphocytes were used as biological effect markers. The population was categorised into exposed and control groups according to the external dose of PAHs. The excretion of 1-HP in the controls over the 3-day period showed a relatively stable baseline, while the exposed showed a significant increase over the same period of time. SCE frequency in the exposed population was significantly different from controls.
authors.affiliation: Department of Environmental and Occupational Medicine, Medical School, University of Newcastle upon Tyne, UK.
authors.forename: B A
authors.initials: BA
authors.lastname: Hatjian
authors.forename: J W
authors.initials: JW
authors.lastname: Edwards
authors.forename: J
authors.initials: J
authors.lastname: Harrison
authors.forename: F M
authors.initials: FM
authors.lastname: Williams
authors.forename: P G
authors.initials: PG
authors.lastname: Blain
mesh_terms: D000328:Adult; D000393:Air Pollutants / Q000032:analysis; D015415:Biomarkers / Q000032:analysis; D004784:Environmental Monitoring / Q000379:methods*; D006801:Humans; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D009153:Mutagens / Q000032:analysis; D016273:Occupational Exposure; D011083:Polycyclic Compounds / Q000009:adverse effects / Q000032:analysis* / Q000493:pharmacokinetics*; D011721:Pyrenes / Q000032:analysis; D012854:Sister Chromatid Exchange / Q000187:drug effects
chemical_list: D000393:Air Pollutants; D015415:Biomarkers; D009153:Mutagens; D011083:Polycyclic Compounds; D011721:Pyrenes; C033146:1-hydroxypyrene