title: Somatic mutations of von Hippel-Lindau (VHL) tumor-suppressor gene in European kidney cancers.
abstract: Somatic mutations of von Hippel Lindau (VHL) tumor-suppressor gene have been identified in kidney cancers from North America and Japan. We studied VHL gene mutation in 31 kidney tumors from France. Of these tumors, 45% (14/31) displayed mutations, 60% of which occurred at A:T base pairs. The frequency and the spectrum of mutations identified in kidney tumors from Europe were similar to those reported for tumors from other geographical locations.
authors.affiliation: Laboratoire d'Oncologie Moleculaire, INSERM CJf 9302, Lyon, France.
authors.forename: M
authors.initials: M
authors.lastname: Bailly
authors.forename: C
authors.initials: C
authors.lastname: Bain
authors.forename: M C
authors.initials: MC
authors.lastname: Favrot
authors.forename: M
authors.initials: M
authors.lastname: Ozturk
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001483:Base Sequence; D001943:Breast Neoplasms / Q000235:genetics; D006528:Carcinoma, Hepatocellular / Q000235:genetics; D002292:Carcinoma, Renal Cell / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D005060:Europe / Q000453:epidemiology; D005091:Exons; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D007680:Kidney Neoplasms / Q000097:blood / Q000453:epidemiology / Q000235:genetics*; D008113:Liver Neoplasms / Q000235:genetics; D008214:Lymphocytes / Q000737:chemistry; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D009154:Mutation; D018807:Polymorphism, Single-Stranded Conformational; D014407:Tumor Cells, Cultured; D006623:von Hippel-Lindau Disease / Q000235:genetics*