Characteristics of peripheral blood monocytes and bone marrow macrophages from rats treated with mitomycin C, 5-fluorouracil or phenylhydrazine.
We examined the cellular functional changes in bone marrow macrophages obtained from rats treated intraperitoneally with mitomycin C (MMC), subcutaneously with 5-fluorouracil (5FU) or intraperitoneally with phenylhydrazine (PHZ) for 7 days to define the mechanisms of toxicity in the bone marrow. The functions of peripheral blood monocytes and bone marrow macrophages were also compared. MMC and PHZ caused anemia, and MMC and 5FU leukocytopenia. Changes in nucleated cell counts were different among the three drug-treatment groups, and MMC- and PHZ-treated bone marrow macrophages were activated for responsiveness to interleukin-1 (IL-1), and their migration activity, intracellular components and enzyme activities were increased. On the other hand, cellular functions of bone marrow macrophages of rats treated with 5FU were suppressed.
Futamura
Y
Y
Department of Pharmacology, Toho University School of Medicine, Tokyo, Japan.
Matsumoto
K
K
D000818:Animals; D001772:Blood Cell Count / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000737:chemistry / Q000187:drug effects; D001854:Bone Marrow Cells; D002465:Cell Movement / Q000187:drug effects; D005472:Fluorouracil / Q000097:blood / Q000633:toxicity*; D007375:Interleukin-1 / Q000032:analysis; D007376:Interleukin-2 / Q000032:analysis; D008264:Macrophages / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D008297:Male; D016685:Mitomycin / Q000097:blood / Q000633:toxicity*; D009000:Monocytes / Q000737:chemistry / Q000187:drug effects*; D010659:Phenylhydrazines / Q000097:blood / Q000633:toxicity*; D051381:Rats; D017472:Receptors, Interleukin-1 / Q000032:analysis; D015375:Receptors, Interleukin-2 / Q000032:analysis
D007375:Interleukin-1; D007376:Interleukin-2; D010659:Phenylhydrazines; D017472:Receptors, Interleukin-1; D015375:Receptors, Interleukin-2; C030299:phenylhydrazine; D016685:Mitomycin; D005472:Fluorouracil