title: [Alanine aminotransferase (ALT)].
abstract: Alanine aminotransferase (Alt, L-alanine:2-oxoglutalate aminotransferase) is a pyridoxal enzyme which catalyses the reversible interconversion of L-alanine and 2-oxoglutalate to pyruvate and L-glutamate. The enzyme is widely distributed in various tissues from animals and even in some kind of plants. Isoenzymes of human ALT localize in the cytosol (c-ALT) and mitochondria (m-ALT) of tissues such as liver, kidney, skeletal and cardiac muscles. Amino acid sequence of c-ALT from rat and human liver has been wholly determined by Ishiguro et al. It is suggested that c-ALT is associated to the utilization of pyruvate in glycolysis and m-ALT is involved in the conversion of alanine to pyruvate for gluconeogenesis.
authors.affiliation: Department of Biochemistry (I), Saitama Medical School.
authors.forename: Y
authors.initials: Y
authors.lastname: Sakagishi
mesh_terms: D000409:Alanine / Q000378:metabolism; D000410:Alanine Transaminase / Q000737:chemistry*; D000595:Amino Acid Sequence; D000818:Animals; D005943:Gluconeogenesis; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry*; D008969:Molecular Sequence Data; D011773:Pyruvates / Q000378:metabolism; D019289:Pyruvic Acid
chemical_list: D007527:Isoenzymes; D011773:Pyruvates; D019289:Pyruvic Acid; D000410:Alanine Transaminase; D000409:Alanine