High prevalence of colorectal cancer in HLA-B27 transgenic F344 rats with chronic inflammatory bowel disease.
OBJECTIVE
Transgenic rats expressing the human major histocompatibility class I molecule HLA-B27 develop a spontaneous multisystem disease that includes a chronic colitis resembling ulcerative colitis. The availability of this phenotype in B27 transgenic rats of 2 different inbred strains provided the opportunity to inquire whether colorectal neoplasia, which occurs with increased frequency in humans with inflammatory bowel disease (IBD), would develop in either or both rat genetic backgrounds.


METHODS
Clinical and histologic evaluation of B27 transgenic rats with chronic inflammatory bowel disease (IBD) on the F344 and LEW inbred backgrounds.


RESULTS
In B27 transgenic rats on an inbred F344 background, hyperplastic lesions evolved in the setting of chronic colitis, with a high frequency of colorectal polyp formation and frequent histologic progression from adenoma to adenocarcinoma. In contrast, no neoplasia occurred in B27 transgenic rats on an inbred LEW background, despite similar colitis.


CONCLUSIONS
A high incidence of spontaneous colorectal neoplasia occurs in a line of B27 F344 rats that shares some features of both sporadic and inflammatory bowel disease-associated human colorectal cancer. This represents a novel example of spontaneous colorectal neoplasia in rodents that is not based on germline modification of one or more already-identified cancer-related genes.
Hammer
R E
RE
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas 75235, USA.
Richardson
J A
JA
Simmons
W A
WA
White
A L
AL
Breban
M
M
Taurog
J D
JD
D000818:Animals; D030801:Animals, Genetically Modified; D002908:Chronic Disease; D015179:Colorectal Neoplasms / Q000235:genetics*; D015796:HLA-B27 Antigen / Q000032:analysis*; D015212:Inflammatory Bowel Diseases / Q000235:genetics*; D051381:Rats; D011916:Rats, Inbred F344; D011917:Rats, Inbred Lew
D015796:HLA-B27 Antigen