Cytogenetic effects of rifampicin in somatic and germinal cells of the mouse.
The genotoxicity of rifampicin was tested for sister chromatic exchange in bone marrow cells and for structural chromosomal aberrations in mouse germ cells. Sister chromatid exchange frequency increased after 160, 240 and 310 mg kg-1 body wt. doses but not after 80 mg kg-1. In spermatocytes, 80 mg kg-1 rifampicin increased the frequency of chromosomal aberrations from the 3.5% control level to 14% after 1 day and 34.5% after 7 days.
Aboul-Ela
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EI
Genetics and Cytology Dept., National Research Centre, Dokki, Cairo, Egypt.
D000818:Animals; D000904:Antibiotics, Antitubercular / Q000008:administration & dosage / Q000633:toxicity*; D001853:Bone Marrow / Q000187:drug effects; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012293:Rifampin / Q000008:administration & dosage / Q000633:toxicity*; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D013090:Spermatocytes / Q000187:drug effects*; D013737:Testis / Q000166:cytology / Q000187:drug effects
D000904:Antibiotics, Antitubercular; D009153:Mutagens; D012293:Rifampin