title: Effects of lacidipine and nifedipine on lower limb veins in nonphlebopathic patients.
abstract: The aim of this study was to evaluate the effect of lacidipine and nifedipine on lower limb veins. Forty hypertensive patients, aged 30-50 years, with no deep venous thrombosis, venous insufficiency, or hypothyroidism underwent double-blind treatment with placebo (1 week), lacidipine 4 mg once daily (1 week), and slow-release nifedipine 20 mg twice daily (1 week) in randomized sequence. Echo-color Doppler examination of superficial, deep, communicating, and perforating veins of the legs was performed. The results showed venous insufficiency and hypertension after 1-week administration of lacidipine (5 and 15%, respectively) and nifedipine (10 and 25%, respectively) and only two cases (5%) of venous hypertension during placebo administration. Lower limb edema was observed in two patients (5%) during treatment with nifedipine slow-release (SR). The hemodynamic effects of lacidipine and nifedipine were reversible but may contribute to the mechanism of lower limb edema.
authors.affiliation: Institute of Cardiovascular Disease, University of Bari, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Ciccone
authors.forename: D
authors.initials: D
authors.lastname: Di Noia
authors.forename: L
authors.initials: L
authors.lastname: Di Michele
authors.forename: F
authors.initials: F
authors.lastname: Corriero
authors.forename: M G
authors.initials: MG
authors.lastname: Biasco
authors.forename: P
authors.initials: P
authors.lastname: Rizzon
mesh_terms: D000328:Adult; D002121:Calcium Channel Blockers / Q000009:adverse effects* / Q000627:therapeutic use; D003692:Delayed-Action Preparations; D004095:Dihydropyridines / Q000009:adverse effects* / Q000627:therapeutic use; D004311:Double-Blind Method; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D006973:Hypertension / Q000150:complications / Q000188:drug therapy; D007866:Leg / Q000098:blood supply* / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009543:Nifedipine / Q000009:adverse effects* / Q000627:therapeutic use; D012039:Regional Blood Flow / Q000187:drug effects; D018615:Ultrasonography, Doppler, Color; D014680:Veins / Q000187:drug effects
chemical_list: D002121:Calcium Channel Blockers; D003692:Delayed-Action Preparations; D004095:Dihydropyridines; C060285:lacidipine; D009543:Nifedipine