title: Anti-inflammatory effects of the novel phosphodiesterase IV inhibitor RP 73401.
authors.affiliation: Rhône-Poulenc Rorer Ltd., Dagenham Research Centre, Dagenham, UK.
authors.forename: J A
authors.initials: JA
authors.lastname: Karlsson
authors.forename: J
authors.initials: J
authors.lastname: Souness
authors.forename: S
authors.initials: S
authors.lastname: Webber
authors.forename: K
authors.initials: K
authors.lastname: Pollock
authors.forename: D
authors.initials: D
authors.lastname: Raeburn
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases; D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001011:Aorta / Q000201:enzymology; D001549:Benzamides / Q000494:pharmacology*; D001986:Bronchial Spasm / Q000188:drug therapy / Q000517:prevention & control; D000242:Cyclic AMP / Q000378:metabolism; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D004353:Drug Evaluation, Preclinical; D004804:Eosinophils / Q000201:enzymology / Q000378:metabolism; D006098:Granulocytes / Q000187:drug effects / Q000201:enzymology; D006168:Guinea Pigs; D006801:Humans; D007527:Isoenzymes / Q000037:antagonists & inhibitors; D007975:Leukotriene B4 / Q000494:pharmacology; D010726:Phosphodiesterase Inhibitors / Q000494:pharmacology*; D010727:Phosphoric Diester Hydrolases; D011725:Pyridines / Q000494:pharmacology*; D011760:Pyrrolidinones / Q000494:pharmacology; D020889:Rolipram; D013552:Swine
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001549:Benzamides; D007527:Isoenzymes; D010726:Phosphodiesterase Inhibitors; D011725:Pyridines; D011760:Pyrrolidinones; D007975:Leukotriene B4; D000242:Cyclic AMP; D010727:Phosphoric Diester Hydrolases; D015105:3',5'-Cyclic-AMP Phosphodiesterases; D054703:Cyclic Nucleotide Phosphodiesterases, Type 4; D020889:Rolipram; C087566:piclamilast