title: Revascularization for femoropopliteal disease. A decision and cost-effectiveness analysis.
abstract: OBJECTIVE
  To evaluate the relative benefits and cost-effectiveness of revascularization for femoropopliteal disease using percutaneous transluminal angioplasty or bypass surgery.
  
  
  METHODS
  Decision analysis using a multistate transition simulation model (Markov process) and cost-effectiveness analysis from the perspective of the health care system.
  
  
  METHODS
  Based on mortality, morbidity, patency, and cost data from a literature review.
  
  
  METHODS
  Hypothetical cohort of patients with chronic femoropopliteal disease who desire revascularization. Subgroup analysis for patients defined by age, sex, indication, lesion type, and graft type.
  
  
  METHODS
  Percutaneous transluminal angioplasty, bypass surgery, and a strategies combining the two treatments.
  
  
  METHODS
  Five-year patency results, quality-adjusted life expectancy, lifetime costs, and incremental cost-effectiveness ratios.
  
  
  RESULTS
  For 65-year-old men with disabling claudication and a femoropopliteal stenosis or occlusion and for 65-year-old men with chronic critical ischemia and a femoropopliteal stenosis, initial angioplasty increased quality-adjusted life expectancy by 2 to 13 months and resulted in decreased lifetime expenditures compared with bypass surgery. For patients with chronic critical ischemia and a femoropopliteal occlusion, initial bypass surgery increased quality-adjusted life expectancy by 1 to 4 months and resulted in decreased lifetime expenditures compared with angioplasty. Sensitivity analysis demonstrated that angioplasty would always be the preferred initial treatment if the angioplasty 5-year patency rate exceeds 30%.
  
  
  CONCLUSIONS
  Angioplasty is the preferred initial treatment in patients with disabling claudication and a femoropopliteal stenosis or occlusion and in those with chronic critical ischemia and a stenosis. Bypass surgery is the preferred initial treatment in patients with chronic critical ischemia and a femoropopliteal occlusion.
authors.affiliation: Department of Health Sciences, University of Groningen, The Netherlands.
authors.forename: M G
authors.initials: MG
authors.lastname: Hunink
authors.forename: J B
authors.initials: JB
authors.lastname: Wong
authors.forename: M C
authors.initials: MC
authors.lastname: Donaldson
authors.forename: M F
authors.initials: MF
authors.lastname: Meyerovitz
authors.forename: J
authors.initials: J
authors.lastname: de Vries
authors.forename: D P
authors.initials: DP
authors.lastname: Harrington
mesh_terms: D000368:Aged; D000714:Anastomosis, Surgical / Q000191:economics; D000800:Angioplasty, Balloon / Q000191:economics; D001807:Blood Vessel Prosthesis / Q000191:economics; D003251:Constriction, Pathologic / Q000601:surgery; D003362:Cost-Benefit Analysis; D003661:Decision Support Techniques; D005260:Female; D005268:Femoral Vein / Q000601:surgery*; D006801:Humans; D007383:Intermittent Claudication / Q000601:surgery; D007511:Ischemia / Q000601:surgery; D007866:Leg / Q000098:blood supply; D008017:Life Expectancy; D008297:Male; D016491:Peripheral Vascular Diseases / Q000191:economics / Q000601:surgery; D011152:Popliteal Vein / Q000601:surgery*; D011788:Quality of Life; D012501:Saphenous Vein / Q000637:transplantation; D014654:Vascular Patency