Resistance to azole drugs in Neurospora crassa.
Neurospora crassa was susceptible to azole drugs: ketoconazole (MIC 1 microgram/ml), fluconazole (MIC 5 micrograms/ml), and SCH39304 (MIC 5 micrograms/ml). Mutants of N. crassa resistant to ketoconazole were selected and genetically characterized. The seven characterized resistance mutations represented at least four genetic loci. Some mutants, but not all, were also resistant to fluconazole and to SCH39304.
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T.H. Morgan School of Biological Sciences, University of Kentucky, Lexington 40506-0225, USA.
D000935:Antifungal Agents / Q000494:pharmacology*; D003433:Crosses, Genetic; D004352:Drug Resistance, Microbial / Q000235:genetics; D015725:Fluconazole / Q000494:pharmacology*; D007654:Ketoconazole / Q000494:pharmacology*; D008540:Meiosis; D016296:Mutagenesis; D009492:Neurospora crassa / Q000187:drug effects* / Q000235:genetics; D012641:Selection, Genetic; D014230:Triazoles / Q000494:pharmacology*
D000935:Antifungal Agents; D014230:Triazoles; C056513:Sch 39304; D015725:Fluconazole; D007654:Ketoconazole