title: Antibody response in patients with osteomyelitis of the mandible.
abstract: Patients with mandibular osteomyelitis had quantification of 10 antibodies against certain bacterial proteins and polysaccharides. Sera from 31 patients with acute or chronic osteomyelitis of the mandible and from 17 healthy controls were analyzed. Some patients showed low levels of investigated antibodies in general and a lack of specific antiteichoic acid antibodies, as well as of different antipneumococcal antibodies particularly. Two patients with therapy-resistant osteomyelitis showed IgG2 and IgG3 subclass deficiency. They had replacement therapy with intravenous 10 or 15 gm immunoglobulin every 3 weeks for 6 months. Both patients showed considerable improvement in their clinical symptoms after treatment with immunoglobulin. This study indicates that impaired humoral immune response may be of importance in subgroups of patients with osteomyelitis of the mandible.
authors.affiliation: Department of Oral and Maxillofacial Surgery, Karolinska Institute, Huddinge, Sweden.
authors.forename: U
authors.initials: U
authors.lastname: Nordin
authors.forename: K
authors.initials: K
authors.lastname: Wannfors
authors.forename: P
authors.initials: P
authors.lastname: Colque-Navarro
authors.forename: R
authors.initials: R
authors.lastname: Möllby
authors.forename: A
authors.initials: A
authors.lastname: Heimdahl
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000907:Antibodies, Bacterial / Q000097:blood; D016667:Bacterial Capsules; D001426:Bacterial Proteins / Q000276:immunology; D016022:Case-Control Studies; D002648:Child; D002908:Chronic Disease; D005260:Female; D006801:Humans; D017099:IgG Deficiency / Q000150:complications* / Q000628:therapy; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use; D008049:Lipase / Q000276:immunology; D008297:Male; D008336:Mandibular Diseases / Q000276:immunology* / Q000382:microbiology; D008875:Middle Aged; D010019:Osteomyelitis / Q000276:immunology* / Q000382:microbiology*; D011008:Pneumococcal Infections / Q000276:immunology; D011135:Polysaccharides, Bacterial / Q000097:blood / Q000276:immunology; D012044:Regression Analysis; D013205:Staphylococcal Protein A / Q000276:immunology; D013682:Teichoic Acids / Q000276:immunology
chemical_list: D000907:Antibodies, Bacterial; D001426:Bacterial Proteins; D016756:Immunoglobulins, Intravenous; D011135:Polysaccharides, Bacterial; D013205:Staphylococcal Protein A; D013682:Teichoic Acids; C056696:pneumococcal polysaccharide, type 14; D008049:Lipase