title: The changing immunology of organ transplantation.
abstract: The engrafted organ becomes a chimera as the recipient's leukocytes station themselves in the transplant. Remarkably, the recipient becomes chimeric as well, in a reverse migration involving immune cells from the graft. Interactions between donor and recipient cells are tolerogenic--a process with implications for the goal of graft acceptance with minimal immunosuppression.
authors.affiliation: University of Pittsburgh, USA.
authors.forename: T E
authors.initials: TE
authors.lastname: Starzl
authors.forename: A J
authors.initials: AJ
authors.lastname: Demetris
authors.forename: N
authors.initials: N
authors.lastname: Murase
authors.forename: M
authors.initials: M
authors.lastname: Trucco
authors.forename: A W
authors.initials: AW
authors.lastname: Thomson
authors.forename: A S
authors.initials: AS
authors.lastname: Rao
mesh_terms: D002465:Cell Movement / Q000276:immunology; D003713:Dendritic Cells / Q000276:immunology; D006085:Graft Survival / Q000276:immunology*; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods / Q000639:trends*; D016377:Organ Transplantation / Q000379:methods / Q000639:trends*; D018183:Transplantation Chimera / Q000276:immunology*; D014181:Transplantation Immunology / Q000276:immunology*