Peptide-mediated immunoregulation.
Quantitative and qualitative characteristics of the signals received by a T cell determine whether receptor ligation results in cell activation, cell death, or the induction of antigen-specific non-responsiveness. Environmental factors such as the nature of costimulation, antigen-presenting cell type, peptide structure and cytokine levels also influence the differentiation of CD4+ helper T cells into functionally distinct subsets, which now appear pivotal in many immune-mediated disorders, including autoimmunity and allergy. Selective manipulation of the immune response, such as the functional inactivation or deviation of the cytokine secretion patterns of specific T cells, may be an effective strategy for immunotherapy.
Hetzel
C
C
Department of Biology, Imperial College of Science, Technology and Medicine, London, UK.
Hoyne
G F
GF
Lamb
J R
JR
D000485:Allergens / Q000276:immunology / Q000494:pharmacology / Q000627:therapeutic use*; D000818:Animals; D017951:Antigen Presentation; D002415:Cats; D016207:Cytokines / Q000502:physiology; D003888:Desensitization, Immunologic / Q000379:methods*; D006023:Glycoproteins / Q000276:immunology / Q000494:pharmacology / Q000627:therapeutic use; D006801:Humans; D006967:Hypersensitivity / Q000276:immunology / Q000628:therapy; D007108:Immune Tolerance / Q000187:drug effects / Q000502:physiology; D051379:Mice; D010446:Peptide Fragments / Q000276:immunology / Q000494:pharmacology / Q000627:therapeutic use*; D018417:Th1 Cells / Q000187:drug effects / Q000276:immunology*; D018418:Th2 Cells / Q000187:drug effects / Q000276:immunology*
D000485:Allergens; D016207:Cytokines; D006023:Glycoproteins; D010446:Peptide Fragments; C059296:Fel d 1 protein, Felis domesticus