title: The role of arginine, indomethacin and kallikrein in the treatment of oligoasthenospermia.
abstract: We have treated 45 patients with various degrees of oligospermia and asthenospermia with arginine, indomethacin and kallikrein. Fifteen patients have received the amino acid L-arginine hydrochloride, 15 the antiinflammatory agent indomethacin, while 15 others the enzyme kallikrein. These drugs have been administered for at least 3 months to encompass a complete cycle of spermatogenesis. As a result, treatment with these drugs has increased sperm count and motility to some extent. Three pregnancies (20%) have been obtained by arginine and one pregnancy (6.6%) by indomethacin. Though arginine offers some hope for the future, improvement of the fertilizing capacity with these drugs is still controversial.
authors.affiliation: Department of Urology, Geyve State Hospital, Sakarya, Turkey.
authors.forename: S
authors.initials: S
authors.lastname: Aydin
authors.forename: O
authors.initials: O
authors.lastname: Inci
authors.forename: B
authors.initials: B
authors.lastname: Alagöl
mesh_terms: D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D001120:Arginine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D006801:Humans; D007213:Indomethacin / Q000627:therapeutic use*; D007610:Kallikreins / Q000627:therapeutic use*; D008297:Male; D009845:Oligospermia / Q000188:drug therapy*; D013076:Sperm Count / Q000187:drug effects; D013081:Sperm Motility / Q000187:drug effects; D016896:Treatment Outcome
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001120:Arginine; D007610:Kallikreins; D007213:Indomethacin