Antioxidative enzyme in the liver of rats after exposure to xylene, toluene and methyl alcohol separately and in combination.
Antioxidative enzymes viz: glutathione peroxidase, glutathione reductase, catalase and aldehyde dehydrogenase were determined in the liver of rats treated with three industrial solvents viz: xylene, toluene and methyl alcohol both separately and in combination. Inhibited activity of glutathione peroxidase suggests reduction of hydroperoxides to corresponding alcohols. However, activity of glutathione reductase increased so as to maintain the glutathione (GSH) reserves. Catalase protected the rats by counteracting the superoxide radicals. However, inhibition of aldehyde dehydrogenase is attributed to the decreased availability of sulfahydryl groups. A trend to optimization of enzyme activities in the liver of co-treated rats suggests enhanced metabolism and excretion of xylene and toluene in the presence of methyl alcohol.
Rana
S V
SV
Department of Zoology, Meerut University, India.
Kumar
S
S
D000444:Aldehyde Dehydrogenase / Q000378:metabolism; D000818:Animals; D002374:Catalase / Q000378:metabolism; D004347:Drug Interactions; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D005980:Glutathione Reductase / Q000378:metabolism; D007700:Kinetics; D008099:Liver / Q000201:enzymology*; D008297:Male; D000432:Methanol / Q000633:toxicity*; D051381:Rats; D012997:Solvents / Q000494:pharmacology; D014050:Toluene / Q000633:toxicity*; D014992:Xylenes / Q000633:toxicity*
D012997:Solvents; D014992:Xylenes; D014050:Toluene; D002374:Catalase; D005979:Glutathione Peroxidase; D000444:Aldehyde Dehydrogenase; D005980:Glutathione Reductase; D005978:Glutathione; D000432:Methanol