Primary antiphospholipid syndrome and neurologic events.
The occurrence of lupus anticoagulant and anticardiolipin antibodies was demonstrated in a girl affected by recurrent episodes of visual disturbances, with ophthalmologic evidence of visual impairment and sometimes accompanied by migraine. Systemic lupus erythematosus was excluded on the basis of both clinical and serologic criteria and the diagnosis of primary antiphospholipid syndrome was made. Vascular pathogenesis was suggested by the characteristic symptoms. The serologic demonstration of antiphospholipid antibodies made it possible to relate the illness to an immune-mediated thrombotic tendency. This patient demonstrated that the diagnosis of primary antiphospholipid syndrome must always be considered in focal cerebral or retinal ischemia in childhood.
Rumi
V
V
Department of Child Neurology, National Neurological Institute C. Besta, Milan, Italy.
Angelini
L
L
Scaioli
V
V
D'Angelo
A
A
Besana
C
C
D017153:Antibodies, Anticardiolipin / Q000097:blood; D016736:Antiphospholipid Syndrome / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D001241:Aspirin / Q000008:administration & dosage; D002648:Child; D003937:Diagnosis, Differential; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004596:Electroretinography / Q000187:drug effects; D005074:Evoked Potentials, Visual / Q000187:drug effects / Q000502:physiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D002546:Ischemic Attack, Transient / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D016682:Lupus Coagulation Inhibitor / Q000097:blood; D011241:Prednisone / Q000008:administration & dosage; D012008:Recurrence; D012164:Retinal Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology; D014786:Vision Disorders / Q000175:diagnosis* / Q000188:drug therapy / Q000276:immunology
D017153:Antibodies, Anticardiolipin; D016682:Lupus Coagulation Inhibitor; D001241:Aspirin; D011241:Prednisone