Fatal pulmonary toxicity following oral etoposide therapy.
Oral etoposide has considerable activity in small cell lung cancer and the low risk of toxicity has resulted in the frequent prescription of this agent in elderly or infirmed patients. We describe a case of fatal pulmonary toxicity following the administration of oral etoposide. This is the first report of biopsy-proven pulmonary toxicity associated with this agent.
Dajczman
E
E
Department of Medicine, Sir Mortimer B. Davis-Jewish General Hospital, McGill University, Montreal, Quebec, Canada.
Srolovitz
H
H
Kreisman
H
H
Frank
H
H
D000284:Administration, Oral; D018288:Carcinoma, Small Cell / Q000175:diagnosis / Q000188:drug therapy*; D005047:Etoposide / Q000009:adverse effects*; D017809:Fatal Outcome; D006801:Humans; D008175:Lung Neoplasms / Q000175:diagnosis / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000139:chemically induced*
D005047:Etoposide