Synthetic approaches and biological evaluation of some new sulfonate ester-containing quinazoline derivatives as potentially active antimicrobial agents.
Several sulfonate ester-containing quinazolinone derivatives that are substituted with, isolated or fused, aryl, hetaryl or hetarylphenyl ring systems were synthesized with a view to evaluate their efficacy as new bactericidal and/or fungicidal agents. Synthesis of these products involved prior preparation of the 2-[4'-(benzenesulfonyloxy)phenyl]-3,1- 4(H)-benzoxazin-4-one derivative (2) and subsequent reaction with several nitrogen nucleophiles. The structure of these products were established from elemental and spectral analyses. Most of the prepared compounds showed high antimicrobial activity, comparable to standard chemotherapeutic agents, when screened against different microorganisms.
Habib
O M
OM
Chemistry Department, Mansoura Faculty of Science, Mansoura University, Egypt.
Girges
M M
MM
Moawad
E B
EB
el-Shafei
A M
AM
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013451:Sulfonic Acids / Q000138:chemical synthesis* / Q000494:pharmacology
D042462:4-Quinolones; D000890:Anti-Infective Agents; D013451:Sulfonic Acids