title: Hypergastrinemia, dysuria-hematuria and metabolic alkalosis: complications associated with gastrocystoplasty.
abstract: OBJECTIVE
  To help determine the etiology and most appropriate treatment regimen for hypergastrinemia, dysuria-hematuria and metabolic alkalosis following augmentation gastrocystoplasty.
  
  
  METHODS
  Two patients who presented with refractory metabolic alkalosis (1 with dysuria-hematuria) underwent extensive laboratory evaluation, complete upper gastrointestinal evaluation and intravesical pH probe placement.
  
  
  RESULTS
  Both patients eventually required high dose oral potassium chloride supplementation. Bladder mucosal pH was not reflected by buffered urinary pH. Both patients demonstrated significant gastroesophageal reflux and diminished overall gastric acid output.
  
  
  CONCLUSIONS
  Outpatient maintenance on potassium chloride supplementation may be warranted in select patients and appears to be preferable to histamine blockade or omeprazole. Postoperative screening esophagogastroscopy and an additional surgical maneuver might be indicated to prevent possible adverse sequelae of reflux esophagitis. Gastrocystoplasty may be an inappropriate operation in children with renal insufficiency who have not had metabolic acidosis.
authors.affiliation: Division of Pediatric Urology, State University of New York, Health Sciences Center at Brooklyn 11203, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Plawker
authors.forename: S S
authors.initials: SS
authors.lastname: Rabinowitz
authors.forename: D J
authors.initials: DJ
authors.lastname: Etwaru
authors.forename: K I
authors.initials: KI
authors.lastname: Glassberg
mesh_terms: D000471:Alkalosis / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005753:Gastric Mucosa / Q000378:metabolism; D005755:Gastrins / Q000097:blood*; D006417:Hematuria / Q000209:etiology*; D006801:Humans; D008297:Male; D011183:Postoperative Complications / Q000209:etiology*; D013270:Stomach / Q000637:transplantation*; D001743:Urinary Bladder / Q000601:surgery*
chemical_list: D005755:Gastrins