[Effects of xenotransplantation of pancreatic islet cells on the immune status of patients with diabetes mellitus].
Before pancreatic islet cell transplantation, the share of diabetes mellitus type 1 patients with immunodeficient conditions amounted to 70.1%. After the surgery it was equal to 22.5%. In diabetes mellitus type 2 these values were 79 and 18%, respectively. The xenotransplantation leads to elevation of T-lymphocytes level in diabetic patients with T-dependent and B-dependent immunodeficiency, but does not correct T-helpers/T-suppressors ratio, which was abnormal in diabetics with autoimmune disorders.
Morozov
Iu I
IuI
Kirdeĭ
E G
EG
Kim
A Iu
AIu
D000818:Animals; D000831:Animals, Newborn; D001327:Autoimmune Diseases / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D003920:Diabetes Mellitus / Q000276:immunology* / Q000601:surgery*; D003922:Diabetes Mellitus, Type 1 / Q000276:immunology / Q000601:surgery; D003924:Diabetes Mellitus, Type 2 / Q000276:immunology / Q000601:surgery; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007153:Immunologic Deficiency Syndromes / Q000276:immunology; D016381:Islets of Langerhans Transplantation; D018655:Lymphocyte Count; D010587:Phagocytosis; D013552:Swine; D013601:T-Lymphocytes / Q000276:immunology; D006377:T-Lymphocytes, Helper-Inducer / Q000276:immunology; D050378:T-Lymphocytes, Regulatory / Q000276:immunology; D014183:Transplantation, Heterologous
D007136:Immunoglobulins