title: Improvement of stress reduces glycosylated haemoglobin levels in patients with type 2 diabetes.
abstract: The effects of reducing stress on glucose metabolism in diabetics were evaluated in 20 patients with type 2 diabetes (10 of each sex) who were given an anxiolytic (fludiazepam) for 12 weeks. Patients were tested 4 weeks before the start of anxiolytic treatment (A), immediately before the first dose (B), and before the end of the study period (C) using the State-Trait Anxiety Index and glycosylated haemoglobin levels. There were no significant differences between the trait or state anxiety scores or the glycosylated haemoglobin levels at times A and B before treatment. However, for all three measurements, the values at time C, after treatment, showed significant improvements, compared with those at both times A and B (P < 0.05). The improvement in the trait anxiety score was weakly correlated with the decrease in the glycosylated haemoglobin level (r = 0.426, P < 0.01). No correlation was seen between state anxiety scores and glycosylated haemoglobin levels. The results suggest that suppressing anxiety in patients with type 2 diabetes reduces glycosylated haemoglobin levels.
authors.affiliation: Third Department of Medicine, Okayama University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Okada
authors.forename: K
authors.initials: K
authors.lastname: Ichiki
authors.forename: S
authors.initials: S
authors.lastname: Tanokuchi
authors.forename: K
authors.initials: K
authors.lastname: Ishii
authors.forename: H
authors.initials: H
authors.lastname: Hamada
authors.forename: Z
authors.initials: Z
authors.lastname: Ota
mesh_terms: D000328:Adult; D000368:Aged; D014151:Anti-Anxiety Agents / Q000627:therapeutic use*; D001007:Anxiety / Q000097:blood* / Q000175:diagnosis / Q000188:drug therapy; D001569:Benzodiazepines; D003924:Diabetes Mellitus, Type 2 / Q000097:blood* / Q000150:complications; D003975:Diazepam / Q000031:analogs & derivatives* / Q000627:therapeutic use; D005260:Female; D006442:Glycated Hemoglobin / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011237:Predictive Value of Tests; D011581:Psychological Tests; D013315:Stress, Psychological / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D014151:Anti-Anxiety Agents; D001569:Benzodiazepines; D003975:Diazepam; D006442:Glycated Hemoglobin; C006107:fludiazepam