Solid-phase synthesis of oxytocin using iodotrichlorosilane as Boc deprotecting agent.
Deprotection of the tert-butoxycarbonyl group during solid-phase synthesis of peptides can be conveniently and efficiently carried out using a neutral reagent, silicon tetrachloride/sodium iodide (iodotrichlorosilane). This simple and rapid method has been advantageously employed during the solid-phase synthesis of the pituitary hormone, oxytocin.
Sivanandaiah
K M
KM
Department of Studies in Chemistry, Central College, Bangalore University, Karnataka, India.
Sureshbabu
V V
VV
Shankaramma
S C
SC
D000595:Amino Acid Sequence; D002712:Chlorides; D002851:Chromatography, High Pressure Liquid; D008969:Molecular Sequence Data; D010121:Oxytocin / Q000138:chemical synthesis*; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry; D017655:Silicon Compounds; D012974:Sodium Iodide
D002712:Chlorides; D010455:Peptides; D017655:Silicon Compounds; D010121:Oxytocin; C039676:silicon tetrachloride; D012974:Sodium Iodide