title: Spinal epidural hematoma following coronary thrombolysis with tissue plasminogen activator. Report of two cases.
abstract: Two cases of spinal epidural hematoma following intravenous administration of recombinant tissue-type plasminogen activator are presented. Both patients received thrombolytic therapy for acute myocardial infarction; back pain and progressive neurological dysfunction ensued, secondary to spinal cord compression caused by epidural hematoma. Both individuals underwent emergency surgery for decompression and hematoma evacuation, resulting in improvement in neurological function. The current status of thrombolytic therapy is reviewed, with emphasis on complications of therapy that require neurosurgical intervention.
authors.affiliation: Division of Neurosurgery, University of Iowa Hospitals and Clinics, Iowa City, USA.
authors.forename: P D
authors.initials: PD
authors.lastname: Sawin
authors.forename: V C
authors.initials: VC
authors.lastname: Traynelis
authors.forename: K A
authors.initials: KA
authors.lastname: Follett
mesh_terms: D000368:Aged; D005260:Female; D006407:Hematoma, Epidural, Cranial / Q000139:chemically induced*; D006801:Humans; D006987:Hypesthesia / Q000209:etiology; D007275:Injections, Intravenous; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy*; D010264:Paraplegia / Q000209:etiology; D013117:Spinal Cord Compression / Q000209:etiology; D015912:Thrombolytic Therapy / Q000009:adverse effects*; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000009:adverse effects*
chemical_list: D010959:Tissue Plasminogen Activator