Stable and unstable genes: distribution among species and range of mutations.
An expansion of the 'stable' gene hypothesis proposed previously is the hypothesis that there is a range of genes, some proto-oncogenes and some not, varying from those with multiple copies in the genome, wide distribution among species, and limited mutability because of a specific protective stabilizing mechanism of such genes, to those that are in single copies in the genome, unprotected, unique to one species, and highly mutable along their entire length.
Frei
J V
JV
Department of Pathology, University of Western Ontario, London, Canada.
D000818:Animals; D005075:Biological Evolution; D005796:Genes; D017491:Genes, APC; D016158:Genes, p53; D016678:Genome; D005838:Genotype; D006801:Humans; D051379:Mice; D018345:Mice, Knockout; D008954:Models, Biological; D008957:Models, Genetic; D009154:Mutation; D013045:Species Specificity