[The participation of the cholinergic systems of the dorsal and ventral striatum in the active avoidance learning of rats in a T maze].
Influence of cholinergic activation of dorsal (caudo-putamen) and ventral (accumbens) striatum on active avoidance learning was studied in chronic experiments in Sprague-Dawley male rats. The results obtained on the same behavioural model testify to specific roles of dorsal and ventral cholinergic systems in the control of motor behaviour. Single carbacholine microinjection into the right Accumbens increased the level of correct responses on the first and subsequent learning days. Similar microinjection into the left accumbens on the first training day improved the level of correct responses on the second and the third learning days. Microinjections into the dorsal striatum did not change active avoidance learning in T maze. Changes in locomotor activity of the animals of different experimental groups were principally of the same nature, i.e., the level of locomotor activity in the open field decreased from trial to trial in all the groups. Carbacholine microinjection did not change spontaneous locomotion in rats. However, there were variations in modifications of locomotor activity induced by microinjections into accumbens depending on localization of the cannula. Injection into the lateral accumbens induced the most pronounced changes. This fact testifies to the functional heterogeneity of this small nucleus.
Shapovalova
K B
KB
Shuvaev
V T
VT
Zhuravin
I A
IA
Pominova
E V
EV
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D002217:Carbachol / Q000008:administration & dosage; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology; D003342:Corpus Striatum / Q000187:drug effects / Q000502:physiology*; D008297:Male; D018782:Maze Learning / Q000187:drug effects / Q000502:physiology*; D008845:Microinjections / Q000379:methods; D009043:Motor Activity / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011950:Receptors, Cholinergic / Q000187:drug effects / Q000502:physiology*; D012601:Scopolamine / Q000008:administration & dosage
D011950:Receptors, Cholinergic; D002217:Carbachol; D012601:Scopolamine