Suppression of macrophage reactive intermediates by cocaine.
The in vivo or in vitro effects of cocaine on the production of hydrogen peroxide (H2O2), superoxide (O2-), and nitrite (NO2-) by sodium periodate-elicited macrophages were studied. Hydrogen peroxide and superoxide productions were suppressed by both in vitro treatments and in vivo administrations of cocaine. The H2O2 and O2- production partially recovered after 150 min in vitro. However, cocaine inhibited NO2- production only in vitro, failing to suppress it through in vivo administration.
Shen
H M
HM
Department of Pathology, College of Medicine, University of Illinois at Chicago, USA.
Sha
L X
LX
Wiederhold
M D
MD
Ou
D W
DW
D000818:Animals; D002478:Cells, Cultured; D003042:Cocaine / Q000494:pharmacology*; D003864:Depression, Chemical; D004306:Dose-Response Relationship, Immunologic; D006861:Hydrogen Peroxide / Q000378:metabolism; D007274:Injections, Intraperitoneal; D008262:Macrophage Activation; D008264:Macrophages / Q000378:metabolism*; D051379:Mice; D009573:Nitrites / Q000378:metabolism; D017382:Reactive Oxygen Species / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism; D013997:Time Factors
D009573:Nitrites; D017382:Reactive Oxygen Species; D013481:Superoxides; D006861:Hydrogen Peroxide; D003042:Cocaine