Cap binding complexes and cellular growth control.
The cap-binding complex eIF-4F plays a major role in the control of translation initiation, and overexpression of its limiting subunit, eIF-4E, leads to the deregulation of cellular growth. The recent cloning of eIF-4E binding proteins (4E-BPs) has uncovered a previously unsuspected pathway for the regulation of eIF-4E activity, through sequestration of eIF-4E as a complex with 4E-BPs.
Mader
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S
Department of Biochemistry, McGill University, Montreal, Quebec, Canada.
Sonenberg
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N
D002455:Cell Division; D039561:Eukaryotic Initiation Factor-4E; D039562:Eukaryotic Initiation Factor-4F; D005786:Gene Expression Regulation / Q000235:genetics; D010448:Peptide Initiation Factors / Q000096:biosynthesis / Q000378:metabolism*; D010766:Phosphorylation; D014176:Protein Biosynthesis / Q000235:genetics; D039381:RNA Cap-Binding Proteins; D012315:RNA Caps / Q000378:metabolism*; D016601:RNA-Binding Proteins / Q000235:genetics / Q000378:metabolism*
D039561:Eukaryotic Initiation Factor-4E; D039562:Eukaryotic Initiation Factor-4F; D010448:Peptide Initiation Factors; D039381:RNA Cap-Binding Proteins; D012315:RNA Caps; D016601:RNA-Binding Proteins