title: Pharmacokinetics and ventilatory effects of intravenous oxycodone in postoperative children.
abstract: 1. Oxycodone hydrochloride (0.1 mg kg-1) was given by intravenous bolus to 18 children after ophthalmic surgery. Plasma was sampled for up to 8 h. Blood pressure, heart rate, peripheral arteriolar oxygen saturation, end-tidal carbon dioxide and halothane concentrations and ventilatory rate were also recorded. 2. Mean (+/- s.d.) values of drug clearance and volume of distribution (Vss) were 15.2 +/- 4.2 ml min-1 kg-1 and 2.1 +/- 0.8 l kg-1. Maximum mean end-tidal carbon dioxide concentration and minimum mean ventilatory rate occurred 8 min after administration of oxycodone but the minimum mean peripheral arteriolar oxygen saturation occurred at 4 min. 3. Oxycodone (0.1 mg kg-1) appears to cause greater ventilatory depression than comparable analgesic doses of other opioids.
authors.affiliation: Department of Anaesthesia, University of Helsinki, Finland.
authors.forename: K T
authors.initials: KT
authors.lastname: Olkkola
authors.forename: K
authors.initials: K
authors.lastname: Hamunen
authors.forename: T
authors.initials: T
authors.lastname: Seppälä
authors.forename: E L
authors.initials: EL
authors.lastname: Maunuksela
mesh_terms: D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006221:Halothane / Q000097:blood; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D013508:Ophthalmologic Surgical Procedures; D010098:Oxycodone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D010149:Postoperative Pain / Q000188:drug therapy*; D012119:Respiration / Q000187:drug effects*; D013990:Tidal Volume
chemical_list: D010098:Oxycodone; D006221:Halothane