title: Reducing effect of 3,4',5-trihydroxystibene-3-beta-mono-D-glucoside on arterial thrombosis induced by vascular endothelial injury.
abstract: OBJECTIVE
  To study the effect of 3,4',5-trihydroxystibene-3-beta-mono-D-glucoside (Polydatin, Pol) on rabbit arterial thrombosis.
  
  
  METHODS
  Rabbit arterial thrombosis was induced by vascular endothelial damage with trypsin.
  
  
  RESULTS
  It was showed that the moist weights of the thrombus were 6.6 +/- 1.8 and 4.8 +/- 1.6 mg in Pol 5 and 10 mg.kg-1 groups, respectively, which was lighter than that in control (10.9 +/- 1.9 mg, P < 0.05, P < 0.01); the platelet aggregation was inhibited simultaneously. In vitro, Pol 0.30-1.15 mmol.L-1 reduced TXA2 produced in platelets. It did not affect the production of PGI2 in cultured human umbilical vein endothelial cells.
  
  
  CONCLUSIONS
  Thrombosis was abated by Pol. The selective inhibition of production of TXA2 rather than PGI2, is one of the mechanisms involved.
authors.affiliation: Department of Pharmacology, First Military Medical University, Guangzhou, China.
authors.forename: Y Z
authors.initials: YZ
authors.lastname: Wang
authors.forename: S F
authors.initials: SF
authors.lastname: Luo
authors.forename: P W
authors.initials: PW
authors.lastname: Zhang
authors.forename: C L
authors.initials: CL
authors.lastname: Yu
mesh_terms: D000818:Animals; D002341:Carotid Artery Thrombosis / Q000517:prevention & control*; D004730:Endothelium, Vascular / Q000473:pathology; D005260:Female; D005960:Glucosides / Q000627:therapeutic use*; D008297:Male; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use*; D011817:Rabbits; D013267:Stilbenes / Q000627:therapeutic use*; D013929:Thromboxane B2 / Q000096:biosynthesis
chemical_list: D005960:Glucosides; D010975:Platelet Aggregation Inhibitors; D013267:Stilbenes; D013929:Thromboxane B2; C058229:polydatin