Pentylenetetrazole kindling impairs long-term memory in rats.
The effect of pentylenetetrazole (PTZ) kindling on learning and retention in active (shuttle-box) and passive (step-down) avoidance was studied in rats. PTZ kindling did not impair learning and significantly disturbed long-term memory estimated from retention tests, i.e. PTZ kindling induced a retrograde amnesia in the active and passive avoidance situations. The present results support the view that memory deficit is an integral part of epilepsy.
Genkova-Papazova
M G
MG
Department of Experimental Pharmacology, Bulgarian Academy of Sciences, Sofia.
Lazarova-Bakarova
M B
MB
D000648:Amnesia, Retrograde / Q000139:chemically induced; D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D007696:Kindling, Neurologic; D008297:Male; D008569:Memory Disorders / Q000139:chemically induced*; D010433:Pentylenetetrazole / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D010433:Pentylenetetrazole