Platelet antiaggregant methoxyphenylthienyl ketoxime ethers: synthesis and structure-activity relationships.
Some new oximinoalkanoic (n = 2,3,4) esters and acids derived from methoxyphenylthienyl ketones have been synthesized and evaluated in vitro for their inhibitory effects on arachidonic acid-induced human platelet aggregation. Of the eighteen oximinoethers tested the most active derivatives, which were four times more active as aspirin, belonged to the para methoxy series with Z configuration and n = 2 or 3.
Varache-Lembège
M
M
Laboratoire de Pharmacie chimique et Chimie thérapeutique, U.F.R. des Sciences pharmaceutiques, Université de Bordeaux II, France.
Nuhrich
A
A
Renard
P
P
Duboudin
F
F
Vercauteren
J
J
Devaux
G
G
D004987:Ethers / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D004987:Ethers; D010975:Platelet Aggregation Inhibitors