Long-term treatment with dimethylthiourea inhibits the development of autoimmune disease in NZB x NZWF1 mice.
Long-term treatment with dimethylthiourea (DMTU), a scavenger of hydroxyl radical (.OH) and hypochlorous acid (HOCl), suppressed the age-related development of autoimmune disease in NZB x NZWF1 mice. Treatment reduced autoantibody production, retarded increase in blood urea nitrogen, and prolonged life. The results suggest that .OH and HOCl may, at least in part, enhance the development of autoimmune diseases in NZB x NZWF1 mice.
Hayashi
T
T
Laboratory of Veterinary Pathology, Faculty of Agriculture, Yamaguchi University, Japan.
Kameyama
Y
Y
Shirachi
T
T
D000818:Animals; D000974:Antibodies, Antinuclear / Q000097:blood / Q000187:drug effects; D001327:Autoimmune Diseases / Q000209:etiology / Q000401:mortality / Q000517:prevention & control*; D001806:Blood Urea Nitrogen; D001835:Body Weight / Q000187:drug effects; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use*; D051379:Mice; D008814:Mice, Inbred NZB; D015996:Survival Rate; D013890:Thiourea / Q000031:analogs & derivatives* / Q000627:therapeutic use
D000974:Antibodies, Antinuclear; D016166:Free Radical Scavengers; C038983:1,3-dimethylthiourea; D013890:Thiourea