Study of HLA class I/IL and T lymphocyte subsets in Kuwaiti vitiligo patients.
HLA polymorphisms of class I and class II MHC were investigated in 40 Kuwaiti vitiligo patients and in 40 controls using microcytotoxicity assay. HLA-B21, Cw6 and DR53 were increased significantly in patients compared to controls (P = 0.00001, 0.00001 and P = 0.0053 respectively) while HLA-A19, DR52, were significantly decreased (P = 0.00236, 0.05, respectively). Total T-cells, T4 and T8 were measured as CD2, CD4 and CD8 respectively by flow cytometry. Vitiligo patients showed significant increase in CD4 compared to controls (P = 0.03). Our findings suggest that HLA-B21 and Cw6 and DR53, are susceptible genes of vitiligo, while A19 and DR52 are protective genes in the Kuwaiti population.
al-Fouzan
A
A
Dermatology Department, Sabah Hospital, Ministry of Public Health Kuwait.
al-Arbash
M
M
Fouad
F
F
Kaaba
S A
SA
Mousa
M A
MA
al-Harbi
S A
SA
D004198:Disease Susceptibility / Q000208:ethnology / Q000276:immunology; D005787:Gene Frequency; D005805:Genes, MHC Class I; D005802:Genes, MHC Class II; D020022:Genetic Predisposition to Disease; D006680:HLA Antigens / Q000235:genetics* / Q000276:immunology; D015235:HLA-B Antigens / Q000235:genetics; D015236:HLA-C Antigens / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D007730:Kuwait / Q000453:epidemiology; D012307:Risk Factors; D016176:T-Lymphocyte Subsets; D014820:Vitiligo / Q000208:ethnology / Q000235:genetics / Q000276:immunology*
D006680:HLA Antigens; D015235:HLA-B Antigens; C063569:HLA-B21 antigen; D015236:HLA-C Antigens; C528994:HLA-C*06 antigen