title: Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue.
abstract: We have determined the chromosomal location of the human and mouse genes encoding the RECQL protein, a putative DNA helicase homologous to the bacterial DNA helicase, RecQ. RECQL was localized to human chromosome 12 by analysis of human-rodent somatic cell hybrid DNA; fine mapping of RECQL by fluorescence in situ hybridization revealed its chromosomal location to be 12p11-p12. The corresponding mouse gene, Recql, was mapped to the telomeric end of mouse chromosome 6 by analysis of DNA from an interspecific cross.
authors.affiliation: Howard Hughes Medical Institute Laboratories, Department of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Puranam
authors.forename: E
authors.initials: E
authors.lastname: Kennington
authors.forename: S N
authors.initials: SN
authors.lastname: Sait
authors.forename: T B
authors.initials: TB
authors.lastname: Shows
authors.forename: J M
authors.initials: JM
authors.lastname: Rochelle
authors.forename: M F
authors.initials: MF
authors.lastname: Seldin
authors.forename: P J
authors.initials: PJ
authors.lastname: Blackshear
mesh_terms: D000251:Adenosine Triphosphatases / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D004265:DNA Helicases / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008809:Mice, Inbred C3H; D053484:RecQ Helicases
chemical_list: D000251:Adenosine Triphosphatases; C506731:RECQL4 protein, human; D004265:DNA Helicases; D053484:RecQ Helicases