title: B-lymphocyte requirement for vaccine-mediated protection from Theiler's murine encephalomyelitis virus-induced central nervous system disease.
abstract: The role of humoral immunity in the protection of vaccinated SJL/J mice from central nervous system disease induced by the DA strain (DAV) of Theiler's murine encephalomyelitis virus was investigated in B-cell-deficient mice. Mice were depleted of B cells by treatment with a mouse monoclonal antibody specific for immunoglobulin M. DAV-vaccinated, B-cell-deficient mice failed to clear viral infection and were no longer protected from Theiler's murine encephalomyelitis virus-mediated central nervous system disease. CD4+ T cells are required in this model of protection to provide help for the development of an antiviral antibody response in the central nervous system.
authors.affiliation: Department of Neurology, University of Utah School of Medicine, Salt Lake City 84132, USA.
authors.forename: C I
authors.initials: CI
authors.lastname: Kurtz
authors.forename: X M
authors.initials: XM
authors.lastname: Sun
authors.forename: R S
authors.initials: RS
authors.lastname: Fujinami
mesh_terms: D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D007111:Immunity, Cellular; D008212:Lymphocyte Depletion; D051379:Mice; D011051:Poliomyelitis / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D017945:Theilovirus / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
chemical_list: D014765:Viral Vaccines