[Activity of lymphocyte NAD(P)-dependent dehydrogenase and level of hormones in the blood of healthy people and patients with recurrent acute respiratory diseases].
The activity of NAD(P)-dependent lymphocyte dehydrogenases and their correlation with the blood levels of hormones was studied in healthy individuals and patients with frequently recurrent acute respiratory diseases. There were decreases in the activity of glucose-6-phosphate-, malate-, NAD-dependent glutamate dehydrogenases and direct and reverse reactions catalyzed by lactate dehydrogenase. In the blood of the examinees, the content of the hormones was similar to the physiological values; however, a decrease in content of thyroglobulin and somatotropin was found in the patients with acute respiratory disease. A model of multiple linear regression was applied to study the interrelationships between the content of hormones and the activity of the NAD(P)-dependent lymphocyte dehydrogenases. Dissimilar alterations in the activity of these enzymes and in their correlation with the content of hormones as compared with those in healthy persons suggest that decreased rates of immunoreactivity in the patients with acute respiratory disease determined by impairments in immunocompetent cell metabolism and in relationships between the immune and the endocrine systems.
Savchenko
A A
AA
Dogadin
S A
SA
Nozdrachev
K G
KG
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D002384:Catalysis; D005260:Female; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D005969:Glutamate Dehydrogenase / Q000097:blood; D013006:Growth Hormone / Q000097:blood*; D006801:Humans; D007770:L-Lactate Dehydrogenase / Q000097:blood; D008214:Lymphocytes / Q000201:enzymology*; D008291:Malate Dehydrogenase / Q000097:blood; D008297:Male; D008875:Middle Aged; D009252:NADPH Dehydrogenase / Q000097:blood*; D012008:Recurrence; D012044:Regression Analysis; D012141:Respiratory Tract Infections / Q000097:blood* / Q000201:enzymology / Q000378:metabolism; D013954:Thyroglobulin / Q000097:blood*
D013006:Growth Hormone; D013954:Thyroglobulin; D007770:L-Lactate Dehydrogenase; D008291:Malate Dehydrogenase; D005954:Glucosephosphate Dehydrogenase; D005969:Glutamate Dehydrogenase; D009252:NADPH Dehydrogenase