title: Spectrophotometric investigation on complex formation of captopril with palladium(II) and its analytical application.
abstract: The formation of the complex between captopril and palladium(II) chloride in Britton-Robinson buffer solution was studied. It has been established that captopril reacts with palladium(II) chloride in the pH range 2.14-9.10 to form a yellow water--soluble 2:1 complex with maximum absorbance at 380 nm. By applying different spectrophotometric methods, the conditional stability constant of the complex at the optimum pH of 4.03 and ionic strength mu = 0.5 M was found to be 108.25). The molar absorptivity was 1.875 x 10(3) l mol-1 cm-1. Beer's law was obeyed in concentrations up to 5 x 10(-4) M captopril. The detection limit was 2.17 micrograms ml-1 and the relative standard deviation varied from 1.24 to 1.68%. The proposed method was found to be suitable for the accurate and reproducible analysis of captopril in water and in tablets.
authors.affiliation: Faculty of Pharmacy, Institute of Analytical and Inorganic Chemistry, Belgrade, Serbia.
authors.forename: T
authors.initials: T
authors.lastname: Jovanović
authors.forename: B
authors.initials: B
authors.lastname: Stanović
authors.forename: Z
authors.initials: Z
authors.lastname: Korićanac
mesh_terms: D002216:Captopril / Q000032:analysis / Q000737:chemistry*; D006863:Hydrogen-Ion Concentration; D010165:Palladium / Q000032:analysis / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013607:Tablets
chemical_list: D013607:Tablets; D010165:Palladium; D002216:Captopril