[Growth of experimental neoplasms in mice with inhibition of endogenous prostaglandin synthesis].
Prostaglandin inhibitor--indomethacin was found to significantly suppress the growth of 5 epithelial transplantable tumors in mice. Simultaneously, it stimulated the development of leukemias L-1210 and La and intraperitoneal melanoma B-16. It was also shown to stimulate the spontaneous development of leukemia in mice AKR. Its growth-inhibiting effect was in direct correlation with the rate of prostaglandin E2 synthesis in tumor. The data obtained point to a specific metabolism of polyunsaturated fatty acids in experimental tumors of varying histogenesis as well as the importance of prostaglandin E2 level for prognosis of the inhibitive effect of indomethacin.
Kudriatsev
I A
IA
Taranenko
I P
IP
D000818:Animals; D015232:Dinoprostone / Q000037:antagonists & inhibitors* / Q000096:biosynthesis; D006801:Humans; D007213:Indomethacin / Q000494:pharmacology*; D007942:Leukemia, Experimental / Q000503:physiopathology; D008297:Male; D008546:Melanoma, Experimental / Q000503:physiopathology; D051379:Mice; D008815:Mice, Inbred Strains; D009374:Neoplasms, Experimental / Q000503:physiopathology*
D015232:Dinoprostone; D007213:Indomethacin