Peripheral blood lymphocyte subsets after allogeneic bone marrow transplantation: reconstitution and correlation with the occurrence of acute graft-versus-host disease.
Peripheral blood lymphocyte subsets were enumerated at regular intervals during the first year after allogeneic bone marrow transplantation (BMT) in 21 Chinese patients. Eight of these patients had acute graft-versus-host disease (GVHD) while they were assessed at the time of engraftment. Our results show in patients receiving allogeneic BMT: (1) T and NK cells were the predominant lymphocyte subsets in the early reconstitution stage while B cells were severely depleted; (2) absolute numbers of the major lymphocyte subsets normalised in 4-5 months; (3) an increased percentage of T cells that expressed the activation antigen HLA-DR and a reversed CD4:CD8 ratio were observed throughout the first 12 months after BMT; (4) patients with acute GVHD had significantly higher white cell count and NK cell percentage than those not complicated by acute GVHD.
Chan
E Y
EY
Department of Pathology, University of Hong Kong, Queen Mary Hospital.
Chiu
E K
EK
So
M K
MK
Lie
A K
AK
Chan
T K
TK
D000208:Acute Disease; D000741:Anemia, Aplastic / Q000276:immunology / Q000628:therapy; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D016026:Bone Marrow Transplantation / Q000276:immunology*; D016516:CD4-CD8 Ratio; D005434:Flow Cytometry; D006086:Graft vs Host Disease / Q000276:immunology*; D006684:HLA-DR Antigens / Q000276:immunology; D006801:Humans; D007938:Leukemia / Q000276:immunology / Q000628:therapy; D018655:Lymphocyte Count; D009101:Multiple Myeloma / Q000276:immunology / Q000628:therapy; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014184:Transplantation, Homologous
D006684:HLA-DR Antigens