title: Gastric intramucosal pH in trauma patients: an index for organ failure risk?
abstract: OBJECTIVE
  To assess if low gastric intramucosal pH (pHi), in the first 24 hours from trauma, is an early risk index for organ failure in severe trauma.
  
  
  METHODS
  Prospective clinical study.
  
  
  METHODS
  General ICU in a university hospital.
  
  
  METHODS
  Thirty-one consecutive trauma patients, aged 15 to 71 years (mean 34.2), 26 men and 5 women.
  
  
  RESULTS
  In all patients pHi was measured using a gastric tonometer. All patients presented systemic inflammatory response syndrome (SIRS) and 14 patients (45.2%) developed sepsis. Seven patients developed one or more organ failures (22.6%). Six patients died (19.4%), five because of organ failure and one because of primary brain injury. The worst 12-24 hour pHi, the worst 24 hours blood Base Excess, APACHE II and ISS were grouped by absence or presence of sepsis, organ failure and by outcome. Patients developing organ failure had pHi values (median = 7.06) significantly lower than patients who did not developed organ failure (median = 7.33) (chi 2 = 5.35; p = 0.02).
  
  
  CONCLUSIONS
  Our data suggest that low pHi during the first 24 hours from trauma seems to be a good predictor for the development of organ failure.
authors.affiliation: Cattedra di Anestesia e Rianimazione, Università degli Studi di Brescia.
authors.forename: A
authors.initials: A
authors.lastname: Toninelli
authors.forename: C
authors.initials: C
authors.lastname: Agapiti
authors.forename: P
authors.initials: P
authors.lastname: Terenghi
authors.forename: N
authors.initials: N
authors.lastname: Latronico
authors.forename: A
authors.initials: A
authors.lastname: Candiani
mesh_terms: D018806:APACHE; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D005745:Gastric Acidity Determination; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D009102:Multiple Organ Failure / Q000453:epidemiology / Q000209:etiology*; D011446:Prospective Studies; D012307:Risk Factors; D013997:Time Factors; D014947:Wounds and Injuries / Q000150:complications* / Q000378:metabolism