Fasting increases the expression of basic fibroblast growth factor (FGF-2) messenger ribonucleic acid in rat hypothalamus.
Basic fibroblast growth factor (FGF-2) has been isolated from the brain, but the regulation of FGF-2 synthesis in the brain is not yet fully understood. Since exogenously administered FGF-2 has been reported to suppress food intake as well as the secretion of gastric acid and pepsin in rats, we examined the effect of fasting on FGF-2 mRNA levels in the hypothalamus and the cerebral cortex of male rats, using RNase protection assay. Fasting for 72 h resulted in an approximately 2-fold increase in FGF-2 mRNA level in the hypothalamus but did not affect FGF-2 mRNA level in the cerebral cortex significantly. These findings support the hypothesis that FGF-2 plays a significant role in regulation of hypothalamic function.
Yoshimura
K
K
Department of Urology, Kobe University School of Medicine, Japan.
Kaji
H
H
Kamidono
S
S
Chihara
K
K
D000315:Adrenalectomy; D000818:Animals; D002540:Cerebral Cortex / Q000378:metabolism; D005215:Fasting / Q000502:physiology*; D016222:Fibroblast Growth Factor 2 / Q000235:genetics*; D015870:Gene Expression; D007031:Hypothalamus / Q000378:metabolism*; D008297:Male; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013965:Thyroidectomy
D012333:RNA, Messenger; D016222:Fibroblast Growth Factor 2