title: Desoxycorticosterone pivalate in the management of canine primary hypoadrenocorticism.
abstract: Primary hypoadrenocorticism in dogs may be poorly responsive to oral fluorocortisone treatment. Desoxycorticosterone pivalate is a suggested alternative treatment in these and all other cases of hypoadrenocorticism. Primary hypoadrenocorticism was diagnosed in a 3-year-old Cocker Spaniel bitch. Treatment with oral fluorocortisone at a dose rate of 0.13 mg 5 kg-1 d-1 was ineffective at maintaining serum electrolyte concentrations within normal limits. Administration of DOCP at a dose of 1.6-2.2 mg kg-1 intramuscularly every 28 d over a 5-year period, successfully maintained normal serum sodium and potassium concentrations. Side-effects encountered were minimal and were dose- or disease-related.
authors.affiliation: Department of Medicine, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Republic of South Africa.
authors.forename: M
authors.initials: M
authors.lastname: Van Zyl
authors.forename: W B
authors.initials: WB
authors.lastname: Hyman
mesh_terms: D000224:Addison Disease / Q000097:blood / Q000188:drug therapy / Q000662:veterinary*; D000818:Animals; D003900:Desoxycorticosterone / Q000008:administration & dosage / Q000627:therapeutic use*; D004283:Dog Diseases / Q000188:drug therapy*; D004285:Dogs; D005260:Female
chemical_list: D003900:Desoxycorticosterone