Protective effect of testosterone against alcohol and paracetamol induced hepatotoxicity in rats.
Chronic ethanol and paracetamol consumption, both individually and in combination, caused hepatic changes in rats. Treatment of testosterone (2.5 mg/kg body wt.) to the alcoholic and paracetamol administered rats showed decreased activities of serum transaminases, serum acid and alkaline phosphatases, and decreased levels of hepatic triglycerides, cholesterol and free fatty acids. Concentration of the lipid peroxidation product-malondialdehyde was significantly decreased in the liver after testosterone treatment in alcohol and paracetamol administered groups. Histopathological observations further confirm that testosterone could offer protection against alcohol and paracetamol induced damage to liver in animals.
Jaya
D S
DS
Department of Biochemistry, University of Kerala, Kariavattom, Trivandrum, India.
Augstine
J
J
Menon
V P
VP
D000082:Acetaminophen / Q000037:antagonists & inhibitors / Q000633:toxicity*; D000818:Animals; D001835:Body Weight; D004435:Eating; D000431:Ethanol / Q000037:antagonists & inhibitors / Q000633:toxicity*; D050356:Lipid Metabolism; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013739:Testosterone / Q000494:pharmacology*
D000082:Acetaminophen; D000431:Ethanol; D013739:Testosterone