Mouse chromosomal location of three EGF receptor ligands: amphiregulin (Areg), betacellulin (Btc), and heparin-binding EGF (Hegfl).
The products of five distinct loci, Egf, Tgfa, Areg, Btc, and Hegfl act as ligands for the epidermal growth factor receptor. Egf and Tgfa have previously been mapped to mouse chromosomes 3 and 6, respectively, but the mouse chromosomal locations of Areg, Btc, and Hegfl have not been reported. Here, we show that Areg and Btc are tightly linked on mouse chromosome 5, while Hegfl maps to mouse chromosome 18. We also provide evidence that a putative sixth family member, Sdgf, is in fact a species variant of Areg. These results confirm and extend known relationships between mouse and human chromosomes, and they also provide new information regarding the evolution of this important gene family.
Pathak
B G
BG
Mammalian Genetics Laboratory, NCI-Frederick Cancer Research and Development Center, Maryland 21702-1201, USA.
Gilbert
D J
DJ
Harrison
C A
CA
Luetteke
N C
NC
Chen
X
X
Klagsbrun
M
M
Plowman
G D
GD
Copeland
N G
NG
Jenkins
N A
NA
Lee
D C
DC
D066258:Amphiregulin; D000818:Animals; D066259:Betacellulin; D002874:Chromosome Mapping; D066255:EGF Family of Proteins; D004815:Epidermal Growth Factor / Q000235:genetics* / Q000378:metabolism; D066246:ErbB Receptors / Q000378:metabolism*; D008040:Genetic Linkage; D006023:Glycoproteins / Q000235:genetics* / Q000378:metabolism; D006133:Growth Substances / Q000235:genetics* / Q000378:metabolism; D066257:Heparin-binding EGF-like Growth Factor; D006801:Humans; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D051379:Mice
C587848:AREG protein, human; D066258:Amphiregulin; C587849:Areg protein, mouse; C587851:BTC protein, human; D066259:Betacellulin; C587852:Btc protein, mouse; D066255:EGF Family of Proteins; D006023:Glycoproteins; D006133:Growth Substances; C587883:HBEGF protein, human; C587884:Hbegf protein, mouse; D066257:Heparin-binding EGF-like Growth Factor; D036341:Intercellular Signaling Peptides and Proteins; D008024:Ligands; D004815:Epidermal Growth Factor; D066246:ErbB Receptors