title: Diminished concentrations of insulin-like growth factor I in cystic fibrosis.
abstract: Cystic fibrosis is frequently accompanied by a catabolic condition with low body mass index caused by a number of disease complications. Insulin-like growth factor-I (IGF-I) is an anabolic hormone and an important marker of nutritional status, liver function, and linear growth. Available data on IGF-I in cystic fibrosis are sparse and conflicting. From 1990-3, 235 of our 240 patients (114 males, 121 females, median age 16.2 years, ranged 0.1-44.0 years) had IGF-I measured once by radioimmunoassay. IGF-I was significantly reduced compared with a healthy Scandinavian control population: mean (-2 SD to +2 SD) IGF-I SD score was -0.97 (-3.7 to 1.7) in males and -0.67 (-3.2 to 1.9) in females. Height SD score was -0.95 (-3.3 to 1.4) in males and -0.81 (-3.2 to 1.6) in females. In patients who were still in the growth period a significant correlation of IGF-I SD score to height SD score (r = 0.28, p < 0.001) was found. The low IGF-I concentrations may reflect the catabolic state of many patients with cystic fibrosis and play a part in their abnormal growth pattern.
authors.affiliation: Department of Growth and Reproduction GR, State University Hospital, Copenhagen, Denmark.
authors.forename: E M
authors.initials: EM
authors.lastname: Laursen
authors.forename: A
authors.initials: A
authors.lastname: Juul
authors.forename: S
authors.initials: S
authors.lastname: Lanng
authors.forename: N
authors.initials: N
authors.lastname: Høiby
authors.forename: C
authors.initials: C
authors.lastname: Koch
authors.forename: J
authors.initials: J
authors.lastname: Müller
authors.forename: N E
authors.initials: NE
authors.lastname: Skakkebaek
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D001827:Body Height / Q000502:physiology; D002648:Child; D002675:Child, Preschool; D003550:Cystic Fibrosis / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007223:Infant; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008168:Lung / Q000503:physiopathology; D008297:Male; D011863:Radioimmunoassay; D012016:Reference Values; D012737:Sex Factors
chemical_list: D007334:Insulin-Like Growth Factor I