Chivosazol A, a new inhibitor of eukaryotic organisms isolated from myxobacteria.
A new antibiotic, chivosazol, was isolated from the culture broth of the myxobacterium Sorangium cellulosum strain So ce12. It is a macrocyclic ring with one oxazol ring and a glycosidically bound 6-deoxyglucose (quinovose) at C-11. The antibiotic shows antimicrobial activity against yeasts and filamentous fungi, and is especially potent against mammalian cells. It was not active against bacteria.
Irschik
H
H
GBF, Gesellschaft für Biotechnologische Forschung, Departments of Biology of Natural Products, Braunschweig, Germany.
Jansen
R
R
Gerth
K
K
Höfle
G
G
Reichenbach
H
H
D000818:Animals; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents / Q000302:isolation & purification* / Q000494:pharmacology; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D018942:Macrolides / Q000302:isolation & purification / Q000494:pharmacology; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009231:Myxococcales; D010080:Oxazoles / Q000302:isolation & purification* / Q000494:pharmacology; D015003:Yeasts / Q000187:drug effects
D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D018942:Macrolides; D010080:Oxazoles; C096623:chivosazol A