title: Cerebrovascular damage in hypertension.
abstract: Hypertension causes marked adaptive changes in the cerebral circulation. The excess risk of stroke associated with hypertension is eliminated in controlled trials of antihypertensive treatment. Such treatment may even prevent transient ischaemic attacks in the elderly. In rare cases, overzealous antihypertensive treatment may cause cerebral ischaemia, especially in the initial treatment of very severe hypertension. Headache may occasionally be caused by severe hypertension, which may also lead to the rare syndrome of acute hypertensive encephalopathy. Finally, the importance of white-matter lesions, or leukoaraiosis, in hypertension is not yet fully established.
authors.affiliation: Department of Medicine and Nephrology B, Herlev Hospital, Copenhagen, Denmark.
authors.forename: S
authors.initials: S
authors.lastname: Strandgaard
authors.forename: O B
authors.initials: OB
authors.lastname: Paulson
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000627:therapeutic use; D001927:Brain Diseases / Q000209:etiology / Q000517:prevention & control; D002545:Brain Ischemia / Q000209:etiology / Q000517:prevention & control; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000209:etiology* / Q000517:prevention & control; D018849:Controlled Clinical Trials as Topic; D006801:Humans; D006973:Hypertension / Q000150:complications* / Q000188:drug therapy; D002546:Ischemic Attack, Transient / Q000209:etiology / Q000517:prevention & control
chemical_list: D000959:Antihypertensive Agents