Asymptotic distributions of polylocus test statistics.
Polylocus linkage analysis methods are modified two-point analyses which aim to approach the information gain of multilocus analysis. Terwilliger and Ott [(1992) Am J Hum Genet 51:A202, (1993) Genet Epidemiol 10:477-482] put forth two such methods. This paper presents asymptotic approximations to the null distribution of the likelihood ratio statistics for these two methods, correcting earlier reports [Terwilliger and Ott (1993) Genet Epidemiol 10:477-482; Schaid and Elston (1994) Genet Epidemiol 11:1-17]. The performance of the approximations is then assessed for finite samples of fully informative meioses.
Goldstein
D R
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Department of Statistics, University of California, Berkeley 94720, USA.
D002874:Chromosome Mapping; D006801:Humans; D008126:Lod Score; D008957:Models, Genetic; D015233:Models, Statistical