T-cell large granular lymphocytic leukemia following orthotopic liver transplantation.
Aggressive T-cell neoplasms are an infrequent complication of allogeneic organ and bone marrow transplantation. To date, chronic T-cell lymphoproliferative malignancies have not been described. The present case documents the occurrence of a T-cell large granular lymphocytic leukemia (T-LGL) in a patient following orthotopic liver transplantation. Genotype studies showed a clonal T-cell receptor beta-chain gene rearrangement. A unique feature was the detection of a specific chromosomal deletion at 1p32 involving the tal-1 gene, an abnormality previously described only in aggressive T-cell neoplasms.
Feher
O
O
Department of Medicine and Pathology, University of Pittsburgh School of Medicine, Pennsylvania, USA.
Barilla
D
D
Locker
J
J
Oliveri
D
D
Melhem
M
M
Winkelstein
A
A
D000328:Adult; D001483:Base Sequence; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D015333:Gene Rearrangement, beta-Chain T-Cell Antigen Receptor; D005838:Genotype; D006509:Hepatitis B / Q000150:complications; D006801:Humans; D007198:Indians, North American; D015458:Leukemia, T-Cell / Q000209:etiology* / Q000235:genetics; D008103:Liver Cirrhosis / Q000601:surgery / Q000821:virology; D016031:Liver Transplantation / Q000009:adverse effects*; D008297:Male; D008969:Molecular Sequence Data