title: Diuretic and antidiuretic effects of mesotocin as compared with the antidiuretic effect of arginine vasotocin in the hen.
abstract: Mesotocin and arginine vasotocin were injected intravenously once at various dosage levels (.0025 to 25 micrograms/kg body weight) immediately after an intravenous injection of 15 mL/kg body weight saline solution into hens in which an artificial anus had been surgically created, and the volume of urine excreted during a 5-h period, following the injection, was measured. Arginine vasotocin caused a monophasic, dose-dependent decrease in urine volume. By contrast, mesotocin was biphasic: at .025 and .25 micrograms/kg body weight it decreased urine volume with the same efficacy as arginine vasotocin, whereas it dramatically increased urine volume at the higher doses (2.5 and 25 micrograms/kg body weight).
authors.affiliation: Department of Animal Science and Technology, Gifu University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
authors.forename: M
authors.initials: M
authors.lastname: Kawashima
authors.forename: T
authors.initials: T
authors.lastname: Yasuoka
authors.forename: M
authors.initials: M
authors.lastname: Kamiyoshi
authors.forename: K
authors.initials: K
authors.lastname: Tanaka
mesh_terms: D000818:Animals; D002645:Chickens; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology; D005260:Female; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014668:Vasotocin / Q000494:pharmacology*
chemical_list: D004232:Diuretics; C001713:mesotocin; D010121:Oxytocin; D014668:Vasotocin