Enhancement of the antitumor effect by combined use of high-energy shock waves and ATX-70.
The antitumor effects of high-energy shock waves (HESW) in combination with ATX-70 [a gallium-porphyrin complex, 2,4-bis(1-decyloxyethyl)-Ga(III)-1,3,5,8-tetramethylporphyrin++ +-6, 7-dipropionyl diaspartic acid [sequence: see text] were investigated. In vitro, the cell damage to mouse MH134 hepatoma after HESW treatment was enhanced by adding ATX-70. In vivo, HESW and ATX-70 combination therapy inhibited cell growth. However, neither HESW treatment alone nor ATX-70 treatment alone inhibited cell growth. These results imply that the antitumor effects of HESW and ATX-70 combined therapy are caused by activation of ATX-70 by HESW.
Maruyama
M
M
Second Department of Surgery, Chiba University School of Medicine.
Asano
T
T
Uematsu
T
T
Nakagohri
T
T
Hasegawa
M
M
Miyauchi
H
H
Iwashita
C
C
Isono
K
K
D000818:Animals; D000970:Antineoplastic Agents / Q000494:pharmacology*; D002455:Cell Division / Q000187:drug effects; D003131:Combined Modality Therapy; D008096:Lithotripsy; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy / Q000628:therapy*; D051379:Mice; D008809:Mice, Inbred C3H; D009368:Neoplasm Transplantation; D017319:Photosensitizing Agents / Q000494:pharmacology*; D011166:Porphyrins / Q000494:pharmacology*
D000970:Antineoplastic Agents; D017319:Photosensitizing Agents; D011166:Porphyrins; C081908:ATX 70