[Multifactor analysis of the effect of pefloxacin on the dynamics of antibody synthesis to EV vaccine fraction 1 and hemagglutinins].
Multifactor analysis of the effect of pefloxacin on the primary immune response to T-independent bacterial antigen (EV vaccine fraction 1) and to T-dependent cellular antigen (sheep erythrocytes) in mice was carried out with the use of a wide variety of the doses and administration times. It was shown that in the doses corresponding to the average therapeutic ones pefloxacin had no affect on the humoral immune response to the EV vaccine fraction 1 antigens while with the use of the subtherapeutic doses the effect was stimulating. When the doses were higher than the therapeutic ones pefloxacin retarded the antibody formation. The pattern of the dose-time dependence of the pefloxacin effect in regard to the immune response to the T-independent and T-dependent antigens was found to be of various types which could be characteristic of the different action of the drug on the populations of the regulatory lymphocytes and antibody-forming cells.
Smolkina
T B
TB
Iordanova
A I
AI
Iudin
S M
SM
Nikitin
A V
AV
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D000942:Antigens, Bacterial / Q000276:immunology*; D001428:Bacterial Vaccines / Q000276:immunology*; D005591:Chemical Fractionation; D004912:Erythrocytes / Q000187:drug effects / Q000276:immunology; D005163:Factor Analysis, Statistical; D006388:Hemagglutinins / Q000494:pharmacology*; D007074:Immunoglobulin G / Q000096:biosynthesis; D007075:Immunoglobulin M / Q000096:biosynthesis; D051379:Mice; D008808:Mice, Inbred CBA; D015366:Pefloxacin / Q000494:pharmacology*; D012756:Sheep
D000942:Antigens, Bacterial; D001428:Bacterial Vaccines; D006388:Hemagglutinins; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015366:Pefloxacin