The sequence of a rat cDNA encoding thrombopoietin.
Overlapping cDNA clones encoding rat thrombopoietin (TPO) were isolated from liver-derived cell line cDNA libraries and the nucleotide sequences were determined. The deduced 326-amino-acid rat TPO showed significant homology to the known TPO of other species, especially in the N-terminal sequence.
Ogami
K
K
Pharmaceutical Research Laboratory, Kirin Brewery Co., Ltd., Gunma, Japan.
Shimada
Y
Y
Sohma
Y
Y
Akahori
H
H
Kato
T
T
Kawamura
K
K
Miyazaki
H
H
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002460:Cell Line; D018076:DNA, Complementary / Q000235:genetics; D015723:Gene Library; D008099:Liver / Q000166:cytology; D008969:Molecular Sequence Data; D011498:Protein Precursors / Q000235:genetics; D021382:Protein Sorting Signals / Q000235:genetics; D051381:Rats; D017422:Sequence Analysis, DNA; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D013926:Thrombopoietin / Q000235:genetics*
D018076:DNA, Complementary; D011498:Protein Precursors; D021382:Protein Sorting Signals; D013926:Thrombopoietin