title: Proton spectroscopy of brain glutamine in acute liver failure.
abstract: Evidence indicates that the accumulation of glutamine in the brain plays an important role in the pathogenesis and severity of the encephalopathy of acute liver failure (ALF). This study uses in vivo proton magnetic resonance spectroscopy (1H MRS) to assess brain glutamine (GLN) in five cases of acute liver failure. The findings are consistent with prior investigations and suggest that the alpha 1H of the GLN molecule can be used for noninvasive spectroscopic quantitation of brain GLN in patients with ALF.
authors.affiliation: Department of Radiology, University of Nebraska Medical Center, Omaha 68198-1045, USA.
authors.forename: J R
authors.initials: JR
authors.lastname: McConnell
authors.forename: D L
authors.initials: DL
authors.lastname: Antonson
authors.forename: C S
authors.initials: CS
authors.lastname: Ong
authors.forename: W K
authors.initials: WK
authors.lastname: Chu
authors.forename: I J
authors.initials: IJ
authors.lastname: Fox
authors.forename: T G
authors.initials: TG
authors.lastname: Heffron
authors.forename: A N
authors.initials: AN
authors.lastname: Langnas
authors.forename: B W
authors.initials: BW
authors.lastname: Shaw
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D001921:Brain / Q000378:metabolism*; D001929:Brain Edema / Q000209:etiology; D002648:Child; D005240:Feasibility Studies; D005544:Forecasting; D005973:Glutamine / Q000378:metabolism*; D006501:Hepatic Encephalopathy / Q000209:etiology / Q000503:physiopathology; D006801:Humans; D007223:Infant; D017093:Liver Failure / Q000150:complications / Q000175:diagnosis* / Q000378:metabolism*; D008279:Magnetic Resonance Imaging; D009682:Magnetic Resonance Spectroscopy; D008297:Male
chemical_list: D005973:Glutamine