title: Differential effect of human immunodeficiency virus infection on the IgA and IgG antibody responses to pneumococcal vaccine.
abstract: The IgA, IgM, and IgG antibody responses to pneumococcal polysaccharide vaccine were analyzed in 35 asymptomatic or mildly symptomatic human immunodeficiency virus (HIV)-infected patients stratified according to their CD4 cell counts and in 12 healthy controls. Both the antibody titers in serum and saliva and the numbers of circulating antigen-specific antibody-producing cells (Elispot technique) were measured. At the peak of the antibody responses, HIV-infected patients mounted nearly normal IgG responses, while their IgM responses were significantly depressed, regardless of their CD4 cell counts. The IgA antibody response was decreased in patients with < 500 CD4 circulating cells/mm3. Most IgG antibodies belonged to the IgG2 subclass, and most IgA antibodies were dimeric IgA2 in both controls and patients. Anti-capsular pneumococcal polysaccharide IgG titers decreased much more rapidly in HIV-infected patients so that in all groups they were significantly lower than in controls 9 months after vaccination.
authors.affiliation: Department of Immunology, Hôpital Erasme, Brussels, Belgium.
authors.forename: F
authors.initials: F
authors.lastname: Mascart-Lemone
authors.forename: M
authors.initials: M
authors.lastname: Gérard
authors.forename: M
authors.initials: M
authors.lastname: Libin
authors.forename: A
authors.initials: A
authors.lastname: Crusiaux
authors.forename: P
authors.initials: P
authors.lastname: Franchioly
authors.forename: A
authors.initials: A
authors.lastname: Lambrechts
authors.forename: M
authors.initials: M
authors.lastname: Goldman
authors.forename: N
authors.initials: N
authors.lastname: Clumeck
mesh_terms: D000328:Adult; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000097:blood*; D000917:Antibody Formation; D001428:Bacterial Vaccines / Q000276:immunology*; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000276:immunology*; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000097:blood / Q000276:immunology*; D006801:Humans; D007114:Immunization; D007070:Immunoglobulin A / Q000096:biosynthesis / Q000097:blood*; D007074:Immunoglobulin G / Q000096:biosynthesis / Q000097:blood*; D008297:Male; D008875:Middle Aged; D011135:Polysaccharides, Bacterial / Q000276:immunology*; D013296:Streptococcus pneumoniae / Q000276:immunology*; D013997:Time Factors
chemical_list: D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D011135:Polysaccharides, Bacterial