hCAP-18, a cathelin/pro-bactenecin-like protein of human neutrophil specific granules.
A 19 kDa protein was identified in specific granules of human neutrophils. A full-length cDNA clone was isolated from a human CML cDNA library, based on amino-acid sequences of isolated tryptic fragments. This clone includes the recently identified cDNA for FALL-39/CAP-18. Aminoacid sequences of proteolytic fragments derived both from the conserved N-terminal cathelin-like region and the highly variable C-terminal region characteristic of this family of bactericidal, LPS binding proteins, were in complete agreement with the sequence deduced from the cDNA. Thus, the 19 kDa protein is hCAP-18, stored as a 'pro-peptide' in specific granules.
Cowland
J B
JB
Department of Hematology, National University Hospital, Copenhagen, Denmark.
Johnsen
A H
AH
Borregaard
N
N
D000595:Amino Acid Sequence; D023181:Antimicrobial Cationic Peptides; D001483:Base Sequence; D002352:Carrier Proteins / Q000032:analysis* / Q000737:chemistry; D054804:Cathelicidins; D003594:Cytoplasmic Granules / Q000737:chemistry*; D017931:DNA Primers; D006801:Humans; D008969:Molecular Sequence Data; D009504:Neutrophils / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry; D011506:Proteins / Q000737:chemistry
D023181:Antimicrobial Cationic Peptides; D002352:Carrier Proteins; D054804:Cathelicidins; D017931:DNA Primers; D010456:Peptides, Cyclic; D011506:Proteins; C084515:cathelin; C056454:bactenecin