title: [Familial occurrence of von Hippel-Lindau disease--a case report].
abstract: It is well known that von Hippel-Lindau disease is defined as the association of retinal angiomatosis and cerebellar hemangioblastomas. This disease is frequently associated with extra-neural vascular neoplasma, especially visceral angiomatous tumors. In this paper we report the familial occurrence of von Hippel-Lindau disease in a 55-year-old mother and her 24-year-old son. The mother had simultaneous multiple angiomas of the liver, stomach and head of the pancreas. The initial symptom was sudden onset of vertigo, possibly caused by a slow-growing cystic cerebellar lesion. An apparent genetic factor indicates that clinical settings begin in the early life of the patients.
authors.affiliation: Department of Neurosurgery, Fukuroi Municipal Hospital, Sizuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ichihashi
authors.forename: H
authors.initials: H
authors.lastname: Harano
authors.forename: J
authors.initials: J
authors.lastname: Mizuno
authors.forename: R
authors.initials: R
authors.lastname: Kasahara
authors.forename: D
authors.initials: D
authors.lastname: Hoshino
authors.forename: H
authors.initials: H
authors.lastname: Nakagawa
mesh_terms: D000328:Adult; D002528:Cerebellar Neoplasms / Q000235:genetics / Q000473:pathology; D005192:Family Health; D005260:Female; D018325:Hemangioblastoma / Q000235:genetics / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000235:genetics / Q000473:pathology; D012164:Retinal Diseases / Q000235:genetics / Q000473:pathology; D013272:Stomach Diseases / Q000235:genetics / Q000473:pathology; D006623:von Hippel-Lindau Disease / Q000235:genetics* / Q000473:pathology