title: Thrombolytic therapy in acute myocardial infarction in Pakistan.
abstract: To characterize features of acute myocardial infarction (AMI) in a Pakistani population, and assess the role of thrombolysis in our country, we studied 194 consecutive admitted patients with enzyme positive AMI. Males were affected three times more frequently; women, although affected less, had a higher incidence of complications than men. Premature coronary artery disease (CAD) was present in 50% patients presenting with AMI. An unusually high incidence of anterior wall myocardial infarction (39%) was seen. Complications were frequent with a predominance of LV failure symptoms. Cardiogenic shock was associated with a very high mortality, in excess of 93%. Streptokinase (SK) was administered in 60% patients with suspected transmural AMI. A statistically significant reduction in mortality was seen in the group that received SK (15.2%) compared to those who did not receive SK (24.7%), (p = < 0.05).
authors.affiliation: Department of Medicine, University of Nebraska Medical Center, Omaha, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Karim
authors.forename: S F
authors.initials: SF
authors.lastname: Mahmood
authors.forename: J
authors.initials: J
authors.lastname: Akhter
authors.forename: A R
authors.initials: AR
authors.lastname: Qureshi
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D010154:Pakistan / Q000453:epidemiology; D012189:Retrospective Studies; D013300:Streptokinase / Q000627:therapeutic use*; D015912:Thrombolytic Therapy
chemical_list: D013300:Streptokinase