Thioredoxin, a mediator of growth inhibition, maps to 9q31.
The human thioredoxin gene has been provisionally mapped to 3p11-p12. Recently thioredoxin cDNA has been isolated in a procedure that detects transcripts coding for growth-suppressing proteins, and thus the chromosomal location of the gene is of particular interest. Chromosome 3 is believed to harbor several tumor suppressor genes important in the development of lung and other common epithelial tumors. To establish more firmly the chromosomal location of the human thioredoxin gene, a somatic hybrid panel was used; it identified chromosome 9 as the location of the transcribed thioredoxin gene. Fluorescence in situ hybridization of a YAC encoding the transcribed thioredoxin gene refined the localization to 9q31.
Heppell-Parton
A
A
MRC Clinical Oncology and Radiotherapeutics Unit, MRC Centre, Cambridge, United Kingdom.
Cahn
A
A
Bench
A
A
Lowe
N
N
Lehrach
H
H
Zehetner
G
G
Rabbitts
P
P
D000818:Animals; D001483:Base Sequence; D018288:Carcinoma, Small Cell / Q000235:genetics / Q000473:pathology; D002874:Chromosome Mapping; D018244:Chromosomes, Artificial, Yeast; D002893:Chromosomes, Human, Pair 3; D002899:Chromosomes, Human, Pair 9; D006224:Cricetinae; D018076:DNA, Complementary / Q000235:genetics; D005796:Genes; D006801:Humans; D006822:Hybrid Cells; D008175:Lung Neoplasms / Q000235:genetics / Q000473:pathology; D008969:Molecular Sequence Data; D013879:Thioredoxins / Q000235:genetics*; D014407:Tumor Cells, Cultured
D018076:DNA, Complementary; D013879:Thioredoxins