title: Clinical significance of tissue polypeptide antigen in serum of acute nonlymphocytic leukemia.
abstract: Tissue polypeptide antigen (TPA) in serum was measured at diagnosis in 27 patients with acute nonlymphocytic leukemia (ANLL) (1 FAB M0, 1 M1, 10 M2, 7 M3, 5 M4, 1 M5, 1 M6 and 1 MU). Statistical analysis disclosed a close correlation of TPA level with age (P < 0.01), hemoglobin level (P < 0.05), therapeutic response (P < 0.01) and the length of survival after the initial diagnosis (P < 0.02). A significant difference in TPA level was present between patients with complete remission and those with poor response. To our knowledge, this is the first report to prove a correlation of TPA level with therapeutic response and the length of survival in ANLL.
authors.affiliation: Department of Hematology, Nagasaki University School of Medicine, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Sadamori
authors.forename: M
authors.initials: M
authors.lastname: Mine
authors.forename: T
authors.initials: T
authors.lastname: Kawachi
authors.forename: T
authors.initials: T
authors.lastname: Hayashibara
authors.forename: T
authors.initials: T
authors.lastname: Itoyama
authors.forename: I
authors.initials: I
authors.lastname: Sasagawa
authors.forename: H
authors.initials: H
authors.lastname: Nakamura
authors.forename: M
authors.initials: M
authors.lastname: Tomonaga
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000951:Antigens, Neoplasm / Q000097:blood*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D014408:Biomarkers, Tumor / Q000097:blood*; D001854:Bone Marrow Cells; D005260:Female; D006454:Hemoglobins / Q000378:metabolism; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000097:blood* / Q000188:drug therapy; D008297:Male; D008875:Middle Aged; D010455:Peptides / Q000097:blood*; D010976:Platelet Count; D011237:Predictive Value of Tests; D011379:Prognosis; D012016:Reference Values; D019396:Tissue Polypeptide Antigen; D016896:Treatment Outcome
chemical_list: D000951:Antigens, Neoplasm; D014408:Biomarkers, Tumor; D006454:Hemoglobins; D010455:Peptides; D019396:Tissue Polypeptide Antigen