[The semiquantitative measurement method of cerebral blood flow using SPECT image].
I devised the convenient semiquantitative measurement method of cerebral blood flow using single photon emission computerized tomography (SPECT) and adapted clinically the method to vascular dementia. SPECT imaging utilized the tracer N-isopropyl-p-[I-123] iodo amphetamine (IMP) and 99mTc-hexamethyl-propyleneamineoxime (HMPAO) with a relative measure of regional tracer uptake normalized to cerebellar radiotracer uptake (rCBF ratios). In order to investigate relationships between dementia and cerebral blood flow, I studied 34 patients with vascular dementia and 20 control subjects by the semiquantitative measurements of relative regional cerebral blood flow (rCBF). In this study I set the lower most normal rCBF ratio (NFL) in IMP-SPECT and HMPAO-SPECT. These NFL of IMP-SPECT were higher than those NFL of HMPAO-SPECT in all cerebral cortices. NFL of IMP-SPECT were nearer to PET's than NFL of HMPAO-SPECT. I indicated rCBF ratio in each region of cerebrum by distinguishing color of SPECT image. In vascular dementia, while IMP-SPECT imaging showed the reduction of rCBF ratio in both of frontal lobes and temporal lobes, HMPAO-SPECT imaging indicated several groups which showed no reduction in temporal lobes. This difference may be due to the lower detection rate of ischemic change in HMPAO-SPECT than IMP-SPECT and it was consistent with many of other reports. This result may suggest usefulness of this method.
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Department of Nuclear Medicine, Hokkaido University School of Medicine, Sapporo, Japan.
D000368:Aged; D000369:Aged, 80 and over; D000662:Amphetamines; D001921:Brain / Q000000981:diagnostic imaging*; D002560:Cerebrovascular Circulation; D015140:Dementia, Vascular / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008297:Male; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D015899:Tomography, Emission-Computed, Single-Photon
D000662:Amphetamines; D007457:Iodine Radioisotopes; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime; D020367:Iofetamine