Mechanism-based development of new antimalarials: synthesis of derivatives of artemisinin attached to iron chelators.
Various derivatives of artemisinin covalently linked to iron chelators were synthesized, and their antimalarial activities were evaluated. Although results show no indication that the presence of an iron chelator in the vicinity of artemisinin potentiates its action, the linked compounds prepared still retain comparable activities to that of artemisinin.
Kamchonwongpaisan
S
S
Department of Biochemistry, Faculty of Science, Mahidol University, Bangkok, Thailand.
Paitayatat
S
S
Thebtaranonth
Y
Y
Wilairat
P
P
Yuthavong
Y
Y
D000818:Animals; D000962:Antimalarials / Q000138:chemical synthesis* / Q000494:pharmacology; D037621:Artemisinins; D015195:Drug Design; D007502:Iron Chelating Agents / Q000737:chemistry*; D010963:Plasmodium falciparum / Q000187:drug effects; D012717:Sesquiterpenes / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D013057:Spectrum Analysis
D000962:Antimalarials; D037621:Artemisinins; D007502:Iron Chelating Agents; D012717:Sesquiterpenes; C031327:artemisinin