A role for ciliary neurotrophic factor as an inducer of reactive gliosis, the glial response to central nervous system injury.
Within the central nervous system (CNS) ciliary neurotrophic factor (CNTF) is expressed by astrocytes where it remains stored as an intracellular protein; its release and function as an extracellular ligand are thought to occur in the event of cellular injury. We find that overexpression of CNTF in transgenic mice recapitulates the glial response to CNS lesion, as does its injection into the uninjured brain. These results demonstrate that CNTF functions as an inducer of reactive gliosis, a condition associated with a number of neurological diseases of the CNS.
Winter
C G
CG
Department of Biochemistry and Molecular Biophysics, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA.
Saotome
Y
Y
Levison
S W
SW
Hirsh
D
D
D000818:Animals; D001253:Astrocytes / Q000502:physiology*; D020934:Ciliary Neurotrophic Factor; D018076:DNA, Complementary; D015870:Gene Expression; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000096:biosynthesis; D005911:Gliosis / Q000139:chemically induced / Q000473:pathology / Q000503:physiopathology*; D006801:Humans; D016177:Macrophage-1 Antigen / Q000032:analysis; D051379:Mice; D008822:Mice, Transgenic; D009410:Nerve Degeneration / Q000187:drug effects; D009414:Nerve Growth Factors / Q000096:biosynthesis / Q000494:pharmacology; D009419:Nerve Tissue Proteins / Q000032:analysis / Q000096:biosynthesis* / Q000494:pharmacology*; D009475:Neurons, Afferent / Q000378:metabolism / Q000473:pathology; D009830:Olfactory Bulb / Q000378:metabolism / Q000473:pathology; D051381:Rats; D011994:Recombinant Proteins / Q000494:pharmacology
D020934:Ciliary Neurotrophic Factor; D018076:DNA, Complementary; D005904:Glial Fibrillary Acidic Protein; D016177:Macrophage-1 Antigen; D009414:Nerve Growth Factors; D009419:Nerve Tissue Proteins; D011994:Recombinant Proteins