title: Identification and chromosomal mapping of a third mouse runt-like locus.
abstract: The Drosophila runt gene, which controls early events in embryogenesis, has been shown to have homologues in human and mouse. The human gene on 21q22 is involved in the t(8;21) associated with acute myeloid leukemia. Two mouse runt-like loci encoding DNA-binding proteins have been identified. We report here the isolation and partial sequence of a molecular clone of a third mouse runt-like locus. By using a panel of somatic cell hybrids and interspecific backcross mice, we map the novel locus to the telomeric region of mouse chromosome 4.
authors.affiliation: Department of Haematology, Royal Postgraduate Medical School, Hammersmith Hospital, London, United Kingdom.
authors.forename: F
authors.initials: F
authors.lastname: Calabi
authors.forename: M
authors.initials: M
authors.lastname: Rhodes
authors.forename: P
authors.initials: P
authors.lastname: Williamson
authors.forename: Y
authors.initials: Y
authors.lastname: Boyd
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D006224:Cricetinae; D003412:Cricetulus; D018076:DNA, Complementary; D004268:DNA-Binding Proteins / Q000235:genetics*; D029721:Drosophila Proteins; D006801:Humans; D006822:Hybrid Cells; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008969:Molecular Sequence Data; D009687:Nuclear Proteins; D017386:Sequence Homology, Amino Acid; D014157:Transcription Factors
chemical_list: D018076:DNA, Complementary; D004268:DNA-Binding Proteins; D029721:Drosophila Proteins; D009687:Nuclear Proteins; D014157:Transcription Factors; C080833:run protein, Drosophila