Urinary excretion of cortisol after immunisation.
Urinary cortisol excretion and rectal temperature were measured in 66 infants before and after immunisation against diphtheria, tetanus, pertussis, and Haemophilus influenzae type b. Immunisation produced a significant increase of rectal temperature the next night at all ages. Infants without an adult-like night time body temperature pattern had a significant increase in urinary cortisol excretion night and morning after immunisation. Once an adult-like night time body temperature pattern developed immunisation no longer significantly raised urinary cortisol output.
Westaway
J
J
Department of Child Health, University of Leicester.
Atkinson
C M
CM
Davies
T
T
Petersen
S A
SA
Wailoo
M P
MP
D000367:Age Factors; D001833:Body Temperature Regulation / Q000502:physiology*; D002940:Circadian Rhythm / Q000502:physiology; D015721:Diphtheria-Tetanus-Pertussis Vaccine / Q000494:pharmacology*; D005260:Female; D018073:Haemophilus Vaccines / Q000494:pharmacology*; D006801:Humans; D006854:Hydrocortisone / Q000652:urine*; D007114:Immunization; D007223:Infant; D008297:Male; D012007:Rectum / Q000502:physiology; D018074:Vaccines, Conjugate / Q000494:pharmacology
D015721:Diphtheria-Tetanus-Pertussis Vaccine; D018073:Haemophilus Vaccines; D018074:Vaccines, Conjugate; C080881:diphtheria-tetanus-pertussis-haemophilus b conjugate vaccine; D006854:Hydrocortisone