Absence of TAP 2D in Yoruba Nigerians.
We have characterized TAP allele frequencies in a panel of 71 Yoruba Nigerians using ARMS-PCR. With the exception that TAP 2D was absent in Nigerians, TAP 2 allele frequencies in this population were found to be similar to those in a UK white population. HLA-DR4 also was found to be at a low frequency in Yoruba Nigerians (1.4%). This may reflect the absence of TAP 2D in Nigerians as DR4 and TAP 2D are in linkage disequilibrium in UK Caucasoids. The most frequent TAP 1 allele in Yoruba Nigerians was TAP 1A (49%). However, this value will be an underestimate as TAP1 alleles could not be unequivocally assigned in 41% of subjects using the ARMS-PCR methodology.
Awomoyi
A A
AA
ARC Epidemiology Research Unit, University of Manchester, UK.
Donn
R P
RP
Davies
E J
EJ
Carthy
D
D
Thomson
W
W
Ollier
W E
WE
D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000328:Adult; D000483:Alleles; D044383:Black People / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D015804:HLA-DR4 Antigen / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D009549:Nigeria; D016133:Polymerase Chain Reaction; D006113:United Kingdom; D044465:White People / Q000235:genetics
D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D015804:HLA-DR4 Antigen; C071692:TAP2 protein, human