Granulomatous interstitial nephritis associated with hydrochlorothiazide/amiloride.
A 74-year-old woman developed acute renal failure and granulomatous interstitial nephritis associated with hydrochlorothiazide/amiloride. On stopping the drug the renal function improved, but not significantly. Around 20 months after prednisone administration, the renal function had stabilized, with a moderate degree of renal insufficiency. The case is discussed, and some aspects of acute interstitial nephritis induced by diuretics are briefly reviewed.
Enríquez
R
R
Section of Nephrology, General Hospital of Elche, Spain.
Cabezuelo
J B
JB
González
C
C
Lacueva
J
J
Teruel
A
A
Fernández
J
J
Arenas
M D
MD
D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000368:Aged; D000584:Amiloride / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use
D006852:Hydrochlorothiazide; D000584:Amiloride; D011241:Prednisone