Food allergens transformed into tolerogens.
Antigen presentation determines immunologic outcome, and by modifying the presentation of allergen to the host one can prevent an allergic response. Under certain conditions, covalent linkage, of ovalbumin to rat IgG, a molecule already tolerated by the host, can make a protein-IgG conjugate which down-regulates the immune response to this food allergen. The suppression is allergen specific. It affects both T and B cell immune responses. Administration of allergens linked to isologous IgG may provide a novel strategy for allergy prevention.
Borel
Y
Y
Nestec Ltd. Research Centre, Lausanne, Switzerland.
Fritsché
R
R
Borel
H
H
Dahlgren
U
U
Dahlman-Höglund
A
A
Telemo
E
E
Hanson
L A
LA
D000485:Allergens / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D000917:Antibody Formation; D017951:Antigen Presentation; D003888:Desensitization, Immunologic; D005512:Food Hypersensitivity / Q000628:therapy*; D007114:Immunization; D018796:Immunoconjugates / Q000008:administration & dosage / Q000627:therapeutic use*; D007074:Immunoglobulin G / Q000008:administration & dosage; D008297:Male; D010047:Ovalbumin / Q000276:immunology / Q000627:therapeutic use / Q000633:toxicity; D051381:Rats; D017207:Rats, Sprague-Dawley
D000485:Allergens; D018796:Immunoconjugates; D007074:Immunoglobulin G; D010047:Ovalbumin