title: Multiple autoantibodies in patients with silicone breast implants.
abstract: Diverse immunologic abnormalities have been described in women who received silicone breast implants. However, most studies have focused on either a limited number of patients or a small panel of autoantibodies. We report the analysis of 20 autoantibodies in 116 women with implants and 134 controls. The patients ranged from 26- to 66-years-old, with a mean of 45.7 +/- 8.3 years; breast prostheses were in place for a mean of 15 +/- 5.6 years, with a range of 4 to 30, the chief complaints of the 116 patients included polyarthralgias, fatigue, myalgias, morning stiffness, and decreased memory. All 250 sera were tested blindly using a panel of 20 autoantigens including SS-A, SS-B, RNP, cardiolipin (CL), collagen types I, II and IV, phosphatidylserine (PS), myeloperoxidase (MPO), sulfatides (sulf), thyroglobulin (TG), gangliosides (GDIa;GM2), proteinase-3 (PR3), Jo-1, Sm, HPRPP-ribosomal phosphate, histones (H2AH2B), Scl-70 and glomerular basement membrane (NC-1). Values from individual patients were considered positive only when greater than 3 SD above the control mean. There was a statistically significant greater frequency of autoantibodies in women with implants for 15 of the 20 autoantigens; these were particularly striking for anti-H2AH2B, HPRPP, SS-A, SS-B, Scl-70, CL, PS, GM2, and NC-1. Many patients harbored several autoantibodies; 20% had four autoantibodies; 8% had six autoantibodies. The association of autoantibodies and implants suggests an adjuvant action of silicon/silicone byproducts.
authors.affiliation: Research Unit of Autoimmune Disease, Sheba Medical Center, Tel-Hashomer, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Bar-Meir
authors.forename: S S
authors.initials: SS
authors.lastname: Teuber
authors.forename: H C
authors.initials: HC
authors.lastname: Lin
authors.forename: I
authors.initials: I
authors.lastname: Alosacie
authors.forename: G
authors.initials: G
authors.lastname: Goddard
authors.forename: J
authors.initials: J
authors.lastname: Terybery
authors.forename: N
authors.initials: N
authors.lastname: Barka
authors.forename: B
authors.initials: B
authors.lastname: Shen
authors.forename: J B
authors.initials: JB
authors.lastname: Peter
authors.forename: M
authors.initials: M
authors.lastname: Blank
mesh_terms: D000276:Adjuvants, Immunologic; D000328:Adult; D000368:Aged; D000918:Antibody Specificity; D001323:Autoantibodies / Q000097:blood* / Q000276:immunology; D001324:Autoantigens / Q000276:immunology; D001327:Autoimmune Diseases / Q000209:etiology* / Q000276:immunology; D001485:Basement Membrane / Q000276:immunology; D001941:Breast Diseases; D018427:Breast Implants / Q000009:adverse effects*; D003094:Collagen / Q000276:immunology; D005260:Female; D005782:Gels; D006801:Humans; D007678:Kidney Glomerulus / Q000276:immunology; D008875:Middle Aged; D011140:Polyurethanes; D011475:Prosthesis Failure; D012216:Rheumatic Diseases / Q000209:etiology* / Q000276:immunology; D012828:Silicones / Q000009:adverse effects*; D016037:Single-Blind Method; D012965:Sodium Chloride; D013954:Thyroglobulin / Q000276:immunology; D013997:Time Factors
chemical_list: D000276:Adjuvants, Immunologic; D001323:Autoantibodies; D001324:Autoantigens; D005782:Gels; D011140:Polyurethanes; D012828:Silicones; D012965:Sodium Chloride; D003094:Collagen; D013954:Thyroglobulin