Outer membrane permeability of beta-lactamase inhibitors in Pseudomonas aeruginosa.
Evaluation of four beta-lactamase inhibitors in terms of their outer membrane permeability in Pseudomonas aeruginosa revealed that sulbactam and tazobactam diffused most efficiently and equally well. That of BRL42715 appeared to be a factor of ten lower than that of the above two, but it showed the strongest beta-lactamase inhibitory activity. This is most likely due to its better beta-lactamase inactivating activity. BRL42715 at 1.56 micrograms ml-1 lowered the minimum inhibitory concentrations of ceftazidime and imipenem in a strain producing fully derepressed beta-lactamase and an undetectable level of the outer membrane protein OprD2.
Satake
S
S
Department of Molecular Life Science, Tokai University School of Medicine, Isehara, Japan.
Nakae
T
T
D002462:Cell Membrane / Q000502:physiology; D002463:Cell Membrane Permeability; D009154:Mutation; D011550:Pseudomonas aeruginosa / Q000502:physiology*; D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases / Q000235:genetics
D065093:beta-Lactamase Inhibitors; D001618:beta-Lactamases