title: Recent insights into the structure, function and biology of cPLA2.
abstract: The 85-kDa cytosolic PLA2 (cPLA2) is present in most cells and tissues and its structural and functional properties have been described. Different agonists, growth factors and cytokines activate cPLA2 to hydrolyze cellular phospholipids thereby providing the precursor substrates for the biosynthesis of eicosanoids and platelet-activating factor (PAF), the well-known mediators of inflammatory and allergic reactions. Recent studies discussed here suggest that cPLA2 is a receptor-regulated enzyme involved in the inflammatory response. Therefore, inhibitors of cPLA2 may be useful as therapeutic agents in the treatment of inflammatory diseases.
authors.affiliation: Lilly Research Laboratories, Indianapolis, Indiana 46285, USA.
authors.forename: R M
authors.initials: RM
authors.lastname: Kramer
authors.forename: J D
authors.initials: JD
authors.lastname: Sharp
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D002384:Catalysis; D003600:Cytosol / Q000201:enzymology*; D004789:Enzyme Activation; D006801:Humans; D007249:Inflammation / Q000201:enzymology; D008969:Molecular Sequence Data; D010741:Phospholipases A / Q000737:chemistry / Q000502:physiology*; D054467:Phospholipases A2; D011956:Receptors, Cell Surface / Q000187:drug effects; D054507:Receptors, Phospholipase A2; D013329:Structure-Activity Relationship
chemical_list: C516360:PLA2R1 protein, human; D011956:Receptors, Cell Surface; D054507:Receptors, Phospholipase A2; D010741:Phospholipases A; D054467:Phospholipases A2