[Opsonizing activity of human immunoglobulin preparations for intravenous use (IVIG)].
It was shown that all the examined immunoglobulin preparations (IVIG) enhance growth of opsonization of S. aureus, S. epidermidis, E. coli which was studied using the chemiluminescence method. However, no opsonization growth was observed of P. aeruginosa rods with the participation of IVIG (except for Sandoglobulin and the specific immunoglobulin Pseudomonas). We assume that such a result was due to the P. aeruginosa strain's susceptibility to lysis factors of the human serum used in the experiment as the complement source. It was confirmed that phagocytosis with the participation of IVIG measured by the chemiluminescence test requires the presence of a complement. The bactericidal test showed that all IVIG preparations, Pentaglobin in particular, are bactericidal and active against P. aeruginosa. Basing on the results obtained, we believe that the biological activity of the Polish preparation is comparable with the investigated IVIG preparations from foreign firms.
Banach
W
W
Zaklad Badania Surowic i Szczepionek PZH w Warszawie.
Bucholc
B
B
D004926:Escherichia coli / Q000187:drug effects; D006801:Humans; D007070:Immunoglobulin A / Q000494:pharmacology; D007075:Immunoglobulin M / Q000494:pharmacology; D016756:Immunoglobulins, Intravenous / Q000096:biosynthesis / Q000494:pharmacology*; D010587:Phagocytosis / Q000187:drug effects*; D011550:Pseudomonas aeruginosa / Q000187:drug effects; D013211:Staphylococcus aureus / Q000187:drug effects; D013212:Staphylococcus epidermidis / Q000187:drug effects
D007070:Immunoglobulin A; D007075:Immunoglobulin M; D016756:Immunoglobulins, Intravenous; C060166:pentaglobulin