Nutrients, signal transduction and carcinogenesis.
Choline phospholipids play major roles in cellular regulation in addition to their essential function as structural components of membranes and lipoproteins. The unique functions of choline phospholipids as hormones (platelet activating factor, 1-alkyl, 2-acetylphosphatidylcholine, PAF) and sources (phosphatidylcholine, sphingolipids) of second messengers (sphingosine, diacylglycerol, lysophospholipids, arachidonic acid and its metabolites) may explain how dietary choline influences normal physiological processes as well as a diverse group of pathological processes, including carcinogenesis.
Zeisel
S H
SH
Department of Nutrition, School of Public Health, University of North Carolina at Chapel Hill 27599-7400, USA.
D000818:Animals; D002796:Choline Deficiency / Q000150:complications / Q000378:metabolism; D006801:Humans; D008099:Liver / Q000378:metabolism; D008114:Liver Neoplasms, Experimental / Q000209:etiology; D009374:Neoplasms, Experimental / Q000209:etiology*; D009747:Nutritional Physiological Phenomena / Q000502:physiology*; D015398:Signal Transduction / Q000502:physiology*