[Treatment of nonspecific hyper-reflectory rhinopathy (vasomotor rhinitis) with capsaicin].
Apart from adrenergic and cholinergic neurones, peptidergic neurones are involved in the autonomic control of nasal mucosa. Their transmitter substances are peptides, so-called "neuropeptides". It is assumed that they are released from peptidergic neurones in the nasal mucosa after irritation of receptors by unspecific stimuli, and are responsible for the symptoms of hyperreactive rhinopathy. Repeated topical application of Capsaicin (8-methyl-N-vanillyl-6-nonenamide) leads to a selective degeneration of peptidergic neurones and desensitisation of its receptors in the nasal mucosa. 123 patients who were suffering from hyperreactive rhinopathy were treated in a prospective study by repeated topical applications of capsaicin solutions in increasing concentrations. A symptom score demonstrated an improvement of the predominating symptoms (nasal congestion, hypersecretion, sneezing) by 62% to 72%. A reduction of unpleasant side effects following application (epiphora, itching, sneezing, mucosal oedema) indicating a desensitising effect could be documented by a symptom score and by active anterior rhinomanometry. Immunohistochemical investigations of nasal mucosa biopsies revealed no reduction of peptidergic neurones within the nasal mucosa, so that a blockage of receptors seems to be responsible for the positive effects. The treatment of hyperreactive rhinopathy with capsaicin or related substances seems to be a promising new way in the treatment of hyperreactive rhinopathy. Further investigations have to prove the site of effect and mechanism of activity of the substance, such as the best modality of application.
Wolf
G
G
Hals-Nasen-Ohren-Universitätsklinik Graz.
Anderhuber
W
W
Hauser-Kronberger
C
C
Saria
A
A
D000281:Administration, Intranasal; D000328:Adult; D000368:Aged; D002211:Capsaicin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009297:Nasal Mucosa / Q000294:innervation; D009474:Neurons / Q000187:drug effects / Q000502:physiology; D011446:Prospective Studies; D018013:Receptors, Neuropeptide / Q000187:drug effects / Q000502:physiology; D012223:Rhinitis, Vasomotor / Q000188:drug therapy* / Q000503:physiopathology
D018013:Receptors, Neuropeptide; D002211:Capsaicin