Acrylic acid oxidation and tissue-to-blood partition coefficients in rat tissues.
We report rates of acrylic acid (AA) oxidation and tissue/blood partition coefficients in rat tissues. AA oxidation in Fischer 344 rat kidney and liver slices was described by saturable kinetics with maximal velocities of about 4 and 2 mumol/h/g, respectively. AA oxidation rates in 11 additional tissues were 40% or less than in liver. AA oxidation rates in Sprague-Dawley rat liver and kidney were similar to those in Fischer rats. Partition coefficients varied within a narrow range, suggesting that a tissue's contribution to systemic detoxification of AA will depend much more strongly on its rate of AA oxidation and the proportion of the cardiac output that it receives.
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Toxicology Department, Rohm and Haas Company, Spring House, PA 19477-0904, USA.
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D000179:Acrylates / Q000097:blood / Q000493:pharmacokinetics*; D000818:Animals; D046508:Culture Techniques; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000378:metabolism*; D008099:Liver / Q000378:metabolism*; D008297:Male; D010084:Oxidation-Reduction; D051381:Rats; D011916:Rats, Inbred F344; D017207:Rats, Sprague-Dawley; D013045:Species Specificity; D014018:Tissue Distribution
D000179:Acrylates; C036658:acrylic acid