title: Antibiotic prophylaxis in cardiac surgery: factors associated with potentially toxic serum concentrations of gentamicin.
abstract: Aminoglycosides are commonly used with flucloxacillin in the prevention of wound infection and endocarditis after cardiac surgery. Earlier studies suggested that the use of aminoglycosides is associated with a small but significant rise in serum creatinine. A regression analysis was performed to identify the preoperative and postoperative factors of importance in determining serum gentamicin concentrations. Serum assays might then be confined to those at particular risk of elevated serum levels. Patients received gentamicin 1.5 mg/kg at the start of surgery followed by 80 mg tds for two days in addition to flucloxacillin. Trough and peak serum gentamicin concentrations were assayed on the first and second days after surgery and urine concentrations were measured with each full catheter bag. Patient characteristics, drug therapy, operation, fluid balance and routine investigations were recorded. A total of 95 of 104 patients were evaluable. Linear discriminant analysis of factors selected by forward stepwise regression identified ten of the 15 patients with subsequent elevated gentamicin concentrations, by using age, and preoperative serum creatinine, systolic blood pressure and serum aspartate transaminase. After operation, factors such as serum creatinine, the quantity of frusemide administered in 24 h, and the integral of the systolic blood pressure over 24 h identified 12 of the 15 patients. However, no satisfactory model could predict urinary concentrations. The discriminant function using preoperative factors prospectively identified 11 of 12 patients with elevated trough levels from a total of 101 further patients. Postoperative gentamicin concentrations cannot reliably be predicted from patient characteristics. Trough assays should be performed or prophylactic courses limited to 24 h.
authors.affiliation: Department of Pharmacy, University College and Middlesex Hospitals, London, UK.
authors.forename: R M
authors.initials: RM
authors.lastname: Heylen
authors.forename: A P
authors.initials: AP
authors.lastname: Wilson
authors.forename: M
authors.initials: M
authors.lastname: Hichens
authors.forename: D
authors.initials: D
authors.lastname: Felmingham
authors.forename: A
authors.initials: A
authors.lastname: Webb
authors.forename: C W
authors.initials: CW
authors.lastname: Pattison
authors.forename: W
authors.initials: W
authors.lastname: Pugsley
mesh_terms: D000328:Adult; D000368:Aged; D006348:Cardiac Surgical Procedures; D005839:Gentamicins / Q000008:administration & dosage / Q000097:blood* / Q000652:urine*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011446:Prospective Studies; D012044:Regression Analysis; D018570:Risk Assessment
chemical_list: D005839:Gentamicins