Protease activity in the mouse dental follicle during tooth eruption.
Eruption results in the movement of the tooth from an intraosseous to a functional position in the mouth. This physiological movement occurs through a path of least resistance and is mediated by the dental follicle. In this study the presence of a 80-kDa proteinase of the gelatinase family in the dental follicle of mandibular first molars obtained from CD-1 mouse neonates was investigated by zymography on sodium dodecyl sulphate-gelatin. The results showed a differential distribution of this proteinase in the coronal and apical parts of the follicle at postnatal days 9 and 11. The findings suggest that the onset of this differential enzymatic activity is concomitant with the initiation of tooth eruption.
Shroff
B
B
Department of Orthodontics, University of Maryland School of Dentistry, Baltimore, USA.
Norris
K
K
Pileggi
R
R
D000818:Animals; D000831:Animals, Newborn; D003795:Dental Sac / Q000201:enzymology*; D004591:Electrophoresis, Polyacrylamide Gel; D018093:Gelatinases / Q000032:analysis / Q000378:metabolism*; D006651:Histocytochemistry; D051379:Mice; D008815:Mice, Inbred Strains; D014078:Tooth Eruption / Q000502:physiology*
D018093:Gelatinases