title: Platelet antiaggregant methoxyphenylthienyl ketoxime ethers: synthesis and structure-activity relationships.
abstract: Some new oximinoalkanoic (n = 2,3,4) esters and acids derived from methoxyphenylthienyl ketones have been synthesized and evaluated in vitro for their inhibitory effects on arachidonic acid-induced human platelet aggregation. Of the eighteen oximinoethers tested the most active derivatives, which were four times more active as aspirin, belonged to the para methoxy series with Z configuration and n = 2 or 3.
authors.affiliation: Laboratoire de Pharmacie chimique et Chimie thérapeutique, U.F.R. des Sciences pharmaceutiques, Université de Bordeaux II, France.
authors.forename: M
authors.initials: M
authors.lastname: Varache-Lembège
authors.forename: A
authors.initials: A
authors.lastname: Nuhrich
authors.forename: P
authors.initials: P
authors.lastname: Renard
authors.forename: F
authors.initials: F
authors.lastname: Duboudin
authors.forename: J
authors.initials: J
authors.lastname: Vercauteren
authors.forename: G
authors.initials: G
authors.lastname: Devaux
mesh_terms: D004987:Ethers / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D006868:Hydrolysis; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D010974:Platelet Aggregation / Q000187:drug effects; D010975:Platelet Aggregation Inhibitors / Q000138:chemical synthesis* / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D004987:Ethers; D010975:Platelet Aggregation Inhibitors