[High tissue concentration of 5-FU reduced local recurrence after administration of tegafur suppositories].
Forty-two patients with head and neck cancer were treated with tegafur suppository for 7 days preoperatively and clinical value of this treatment was assessed. In a group which indicated tumor tissue concentrations of 5-FU were more than 0.5 micrograms/g, local recurrence decreased in the period of postoperative observation for 42 months. A survival rate of this group was better than others. From these results, preoperative tegafur suppository treatment seemed to have a role in expectation of improvement of local control in head and neck cancer therapy.
Koja
S
S
Dept. of Otorhinolaryngology, University of the Ryukyus Faculty of Medicine.
Itokazu
T
T
Maeshiro
N
N
Matsumura
J
J
Maeda
H
H
Yasuda
S
S
Kochi
A
A
Noda
Y
Y
D017024:Chemotherapy, Adjuvant; D005472:Fluorouracil / Q000493:pharmacokinetics*; D006258:Head and Neck Neoplasms / Q000188:drug therapy* / Q000378:metabolism / Q000473:pathology / Q000601:surgery; D006801:Humans; D008207:Lymphatic Metastasis; D009364:Neoplasm Recurrence, Local; D011300:Preoperative Care; D013488:Suppositories; D005641:Tegafur / Q000008:administration & dosage* / Q000493:pharmacokinetics
D013488:Suppositories; D005641:Tegafur; D005472:Fluorouracil