title: In vivo induction of apoptosis by influenza virus.
abstract: Intranasal exposure of mice to influenza virus led to cell death in bronchial/bronchiolar epithelial cells, alveolar cells and lymphoid cells. These cells displayed fragmentation of nuclei and chromatin condensation. Nick end-labelling of DNA in situ confirmed that such apoptotic cells had fragmented DNA. These results suggest that the influenza virus induces apoptosis in vivo.
authors.affiliation: Department of Microbiology, Fukui Medical School, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Mori
authors.forename: T
authors.initials: T
authors.lastname: Komatsu
authors.forename: K
authors.initials: K
authors.lastname: Takeuchi
authors.forename: K
authors.initials: K
authors.lastname: Nakakuki
authors.forename: M
authors.initials: M
authors.lastname: Sudo
authors.forename: Y
authors.initials: Y
authors.lastname: Kimura
mesh_terms: D000818:Animals; D017209:Apoptosis; D001980:Bronchi / Q000473:pathology*; D002843:Chromatin / Q000502:physiology; D004249:DNA Damage; D004848:Epithelium / Q000473:pathology; D006801:Humans; D009980:Influenza A virus / Q000502:physiology*; D007251:Influenza, Human / Q000473:pathology* / Q000821:virology; D008168:Lung / Q000473:pathology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013950:Thymus Gland / Q000473:pathology*; D013997:Time Factors
chemical_list: D002843:Chromatin