title: The incidence of giant cell arteritis in Olmsted County, Minnesota: apparent fluctuations in a cyclic pattern.
abstract: OBJECTIVE
  To investigate trends in the incidence of giant cell arteritis over a 42-year period in Olmsted County, Minnesota.
  
  
  METHODS
  Population-based incidence study.
  
  
  METHODS
  Olmsted County, Minnesota.
  
  
  METHODS
  All incidence cases of giant cell arteritis first diagnosed between 1950 and 1991 were identified using the unified record system at Mayo Clinic. Age- and sex-specific incidence rates were calculated using the number of incidence cases as the numerator and population estimates as the denominator. Overall rates were age- and sex-adjusted to the 1980 United States white population. The annual incidence rates were graphically illustrated using a 3-year centered moving average.
  
  
  RESULTS
  Between 1950 and 1991, 125 Olmsted County residents (103 women and 22 men) were diagnosed with giant cell arteritis. The age- and sex-adjusted incidence per 100,000 persons 50 years of age or older was 17.8 (95% CI, 14.7 to 21.0); incidence was significantly higher in women (24.2 [CI, 19.5 to 28.9]) than in men (8.2 [CI, 4.8 to 11.6]). Age-specific incidence rates increased with age (P < 0.0001). The annual incidence rates increased significantly over the study period (P = 0.002) and appear to have clustered in five peak periods, which occurred about every 7 years. A significant calendar-time effect was identified; it predicted an increase in incidence of 2.6% (CI, 0.9% to 4.3%) every 5 years.
  
  
  CONCLUSIONS
  Our observation of a regular cyclic pattern in incidence rates over time supports the hypothesis of an infectious cause for giant cell arteritis. Similar studies in other populations are needed to confirm our findings.
authors.affiliation: Mayo Clinic, Rochester, Minnesota, USA.
authors.forename: C
authors.initials: C
authors.lastname: Salvarani
authors.forename: S E
authors.initials: SE
authors.lastname: Gabriel
authors.forename: W M
authors.initials: WM
authors.lastname: O'Fallon
authors.forename: G G
authors.initials: GG
authors.lastname: Hunder
mesh_terms: D017677:Age Distribution; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D013700:Giant Cell Arteritis / Q000453:epidemiology*; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D008910:Minnesota / Q000453:epidemiology; D010507:Periodicity; D017678:Sex Distribution