title: Host restriction phenotypes of Salmonella typhi and Salmonella gallinarum.
abstract: Salmonella typhi and Salmonella gallinarum phenotypes correlated with mouse host restriction have been identified by using in vitro and in vivo systems. S. typhi is capable of entering the murine intestinal epithelium via M cells, as is Salmonella typhimurium, which causes systemic infection in the mouse. But, unlike S. typhimurium, S. typhi does not destroy the epithelium and is cleared from the Peyer's patches soon after M-cell entry. S. gallinarum appears to be incapable of entering the murine Peyer's patch epithelium. Our in vitro evidence suggests that S. gallinarum is taken up in murine phagocytic cells by a mechanism different from that of S. typhimurium. S. typhimurium is taken up at a higher frequency and is maintained at higher viable counts throughout a 24-h time course in a murine macrophage-like cell line than are S. gallinarum and S. typhi.
authors.affiliation: Rocky Mountain Laboratories, Hamilton, Montana 59840, USA.
authors.forename: L
authors.initials: L
authors.lastname: Pascopella
authors.forename: B
authors.initials: B
authors.lastname: Raupach
authors.forename: N
authors.initials: N
authors.lastname: Ghori
authors.forename: D
authors.initials: D
authors.lastname: Monack
authors.forename: S
authors.initials: S
authors.lastname: Falkow
authors.forename: P L
authors.initials: PL
authors.lastname: Small
mesh_terms: D000818:Animals; D001422:Bacterial Adhesion; D002478:Cells, Cultured; D003599:Cytoskeleton / Q000648:ultrastructure; D005260:Female; D007082:Ileum / Q000382:microbiology; D007413:Intestinal Mucosa / Q000382:microbiology; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D010581:Peyer's Patches / Q000382:microbiology; D012475:Salmonella / Q000472:pathogenicity*; D012485:Salmonella typhi / Q000472:pathogenicity*; D013045:Species Specificity; D014741:Video Recording