title: Comparison of fluid volumes with whole bowel irrigation in a simulated overdose of ibuprofen.
abstract: OBJECTIVE
  To determine the effect of 2 different fluid volumes of polyethylene glycol whole bowel irrigation (WBI) solution on absorption of an ingested toxin in a simulated overdose model.
  
  
  METHODS
  Prospective, randomized, crossover trial.
  
  
  METHODS
  Clinical research unit.
  
  
  METHODS
  Nine adult men.
  
  
  METHODS
  On 2 separate days, volunteers ingested approximately 75 mg/kg of ibuprofen. In treatment 1, 30 minutes after ingestion of ibuprofen, a 3-L WBI at 2 L/h was begun. This procedure was repeated in treatment 2 with an 8-L. WBI administered at 2 L/h. Fourteen timed serum samples were collected prior to and after drug ingestion for a 24-hour period and analyzed for ibuprofen concentration. The peak serum concentration, time to peak concentration, total area under the serum concentration-time curve (AUC), clearance, and volume of distribution were compared.
  
  
  RESULTS
  The mean +/- SD AUCs did not differ between the 3-L (1185.3 +/- 216.9 mg.h/L) and 8-L (1153.5 +/- 251.5 mg.h/L) treatments (p = 0.710). Time to peak serum concentration, peak serum concentration, clearance, and volume of distribution were comparable for the 2 treatments (p > 0.05).
  
  
  CONCLUSIONS
  These data indicated that a total WBI volume of 3 L would be expected to perform as well as 8 L administered at the same rate. We recommend that further research define the optimal dose of WBI in acute ingestion of toxins.
authors.affiliation: Department of Pharmacy Practice, University of Nebraska Medical Center, Omaha 68198, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Olsen
authors.forename: B J
authors.initials: BJ
authors.lastname: Gurley
authors.forename: G A
authors.initials: GA
authors.lastname: Davis
authors.forename: S R
authors.initials: SR
authors.lastname: Archer
authors.forename: F H
authors.initials: FH
authors.lastname: Ma
authors.forename: B H
authors.initials: BH
authors.lastname: Ackerman
mesh_terms: D000328:Adult; D062787:Drug Overdose / Q000628:therapy; D006801:Humans; D007052:Ibuprofen / Q000378:metabolism / Q000506:poisoning*; D007422:Intestines / Q000502:physiology*; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000494:pharmacology; D011446:Prospective Studies; D007507:Therapeutic Irrigation
chemical_list: D011092:Polyethylene Glycols; D007052:Ibuprofen