title: Surgical treatment and prognostic variables of hepatocellular carcinoma in 122 cirrhotics.
abstract: A 10-year experience in surgical treatment of HCC in 122 cirrhotic patients has been reviewed in order to evaluate: perioperative mortality and morbidity, survival rates and prognostic variables by multiple-logistic analysis. Mortality rate declined from 7% in period 1983-88 to 2% in period 1989-92. Operative complications also decreased from 46% to 30%. The 3-year and 5-year overall survival rates were 42.6% and 23.3%. The 3-year and 5-year survival of patients who died only for HCC was 51.1% and 34.2% and the disease-free survival 30.6% and 19.1%. The good results of overall survival were vanished by the high rate of recurrence (19.1%). Multiple logistic regression analysis for the probability of mortality was significant for satellite nodules (RR 2.437), microvascular infiltration (RR 2.432), tumor size (RR 1.147); the model for the probability of recurrence was significant for microvascular infiltration (RR 2.290), satellite nodules (RR 2.280), lesions number (RR 2.216) and tumor size (RR 1.247).
authors.affiliation: University of Milan, Institute of General Surgery, IRCCS San Raffaele, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Di Carlo
authors.forename: G
authors.initials: G
authors.lastname: Ferrari
authors.forename: R
authors.initials: R
authors.lastname: Castoldi
authors.forename: S
authors.initials: S
authors.lastname: Nadalin
authors.forename: C
authors.initials: C
authors.lastname: Marenghi
authors.forename: B
authors.initials: B
authors.lastname: Molteni
authors.forename: G
authors.initials: G
authors.lastname: Taccagni
authors.forename: M
authors.initials: M
authors.lastname: Castrucci
mesh_terms: D006528:Carcinoma, Hepatocellular / Q000150:complications / Q000401:mortality* / Q000601:surgery*; D005260:Female; D006498:Hepatectomy; D006801:Humans; D015994:Incidence; D007558:Italy / Q000453:epidemiology; D008103:Liver Cirrhosis / Q000150:complications*; D008113:Liver Neoplasms / Q000150:complications / Q000401:mortality* / Q000601:surgery*; D016015:Logistic Models; D008297:Male; D008875:Middle Aged; D009017:Morbidity; D009364:Neoplasm Recurrence, Local / Q000401:mortality; D011379:Prognosis; D016019:Survival Analysis; D015996:Survival Rate; D013997:Time Factors