Intralesional steroid-therapy-induced reduction of plasma interleukin-6 and improvement of cutaneous plasmacytosis.
We describe a case of primary multiple cutaneous plasmacytosis successfully treated by intralesional steroid therapy. Plasma interleukin-6 (IL-6) levels reduced in parallel with the disease activity. Intralesional steroid reduced IL-6 production by peripheral blood mononuclear cells, while neither PUVA therapy nor intralesional recombinant interferon-gamma resulted in a benefit and plasma IL-6 levels did not decrease. It was suggested that IL-6 might play an important role in the pathogenesis of this condition.
Yamamoto
T
T
Department of Dermatology, Tokyo Medical and Dental University School of Medicine, Japan.
Soejima
K
K
Katayama
I
I
Nishioka
K
K
D006801:Humans; D006942:Hypergammaglobulinemia / Q000473:pathology; D015552:Injections, Intralesional; D007371:Interferon-gamma / Q000008:administration & dosage / Q000627:therapeutic use; D015850:Interleukin-6 / Q000097:blood*; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011701:PUVA Therapy; D010950:Plasma Cells / Q000276:immunology / Q000473:pathology*; D012871:Skin Diseases / Q000188:drug therapy* / Q000276:immunology; D014222:Triamcinolone Acetonide / Q000008:administration & dosage / Q000627:therapeutic use*
D015850:Interleukin-6; D007371:Interferon-gamma; D014222:Triamcinolone Acetonide