title: Pneumoconiosis and systemic sclerosis following 10 years of exposure to polyvinyl chloride dust.
abstract: The case history is presented of a 58 year old man who was exposed to thermoplastic dusts, mainly polyvinyl chloride (PVC), for 10 years. Radiography and high resolution computed tomographic scans of the lungs suggested both pneumoconiotic and scleroderma-like lesions. Transbronchial biopsy revealed foreign body granulomas with macrophages laden with birefringent inclusions which ultrastructurally resembled PVC dust. Biopsy samples of thickened skin showed histological evidence of extensive fibrosis. During follow up Raynaud's phenomenon and oesophageal involvement developed. The antinuclear antibody titre was 1:640, and the Sc1-70 subset was positive. It is concluded that exposure to PVC dust may cause pneumoconiosis and secondary systemic sclerosis.
authors.affiliation: First Internal Department, Centre for Pulmonary Disease, Vienna, Austria.
authors.forename: M J
authors.initials: MJ
authors.lastname: Studnicka
authors.forename: G
authors.initials: G
authors.lastname: Menzinger
authors.forename: M
authors.initials: M
authors.lastname: Drlicek
authors.forename: H
authors.initials: H
authors.lastname: Maruna
authors.forename: M G
authors.initials: MG
authors.lastname: Neumann
mesh_terms: D002617:Chemical Industry; D004391:Dust / Q000009:adverse effects*; D015745:Granuloma, Foreign-Body / Q000473:pathology; D006801:Humans; D008168:Lung / Q000473:pathology / Q000648:ultrastructure; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D011009:Pneumoconiosis / Q000209:etiology* / Q000473:pathology; D011143:Polyvinyl Chloride / Q000009:adverse effects*; D012594:Scleroderma, Localized / Q000139:chemically induced* / Q000473:pathology
chemical_list: D004391:Dust; D011143:Polyvinyl Chloride