title: Effective treatment with alpha 1-protease inhibitor of chronic cutaneous vasculitis associated with alpha 1-antitrypsin deficiency.
abstract: The primary serum proteinase inhibitor is alpha 1-antitrypsin, and deficiency of this enzyme has been associated with a variety of systemic and cutaneous disorders. We report cutaneous vasculitis in a 49-year-old man with alpha 1-antitrypsin deficiency. His condition persisted despite treatment with colchicine, prednisone, and antibiotics but has been controlled by the administration of alpha 1-protease inhibitor.
authors.affiliation: Division of Dermatology, University of Louisville School of Medicine, KY, USA.
authors.forename: S K
authors.initials: SK
authors.lastname: Dowd
authors.forename: G C
authors.initials: GC
authors.lastname: Rodgers
authors.forename: J P
authors.initials: JP
authors.lastname: Callen
mesh_terms: D002908:Chronic Disease; D006801:Humans; D008297:Male; D008875:Middle Aged; D014657:Vasculitis / Q000209:etiology / Q000628:therapy*; D000515:alpha 1-Antitrypsin / Q000627:therapeutic use*; D019896:alpha 1-Antitrypsin Deficiency
chemical_list: D000515:alpha 1-Antitrypsin