title: Effect of isosorbide on hearing loss due to endolymphatic hydrops.
abstract: Changes in hearing were studied in 145 ears (103 patients) with endolymphatic hydrops before and after an 8-week administration of isosorbide. Hearing improvement was observed in 57 (39.3%) of the 145 ears. These improvements showed a significant correlation with positive results in the glycerol test (p < 0.01). Of the 46 ears with a positive result, hearing was improved in 32 (69.6%). Therefore, results of the glycerol test predict a response to isosorbide therapy for the hearing loss of endolymphatic hydrops.
authors.affiliation: Department of Otolaryngology, Kochi Medical School, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kakigi
authors.forename: T
authors.initials: T
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Saito
authors.forename: H
authors.initials: H
authors.lastname: Kataoka
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D018159:Endolymphatic Hydrops / Q000150:complications*; D005990:Glycerol; D006309:Hearing / Q000187:drug effects; D006311:Hearing Disorders / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D006801:Humans; D007547:Isosorbide / Q000627:therapeutic use*; D008875:Middle Aged; D012684:Sensory Thresholds
chemical_list: D005990:Glycerol; D007547:Isosorbide