title: Sertaconazole in the treatment of pediatric patients with cutaneous dermatophyte infections.
abstract: Sertaconazole is a new topical anti-mycotic with demonstrated efficacy against dermatophyte infections in adults. An open-label, multicenter study was conducted to assess the efficacy and tolerability of sertaconazole in children in primary care. Twenty-nine children were initially included in the study and tolerability was assessed in all of them. The 16 children examined for efficacy (8 girls and 8 boys, aged 2 to 16 years) all had culture-confirmed cutaneous mycoses. Fourteen children had tinea corporis, 1 had tinea cruris, and 1 had tinea pedis. Microsporum canis was identified in 50% of cultures and Trichophyton rubrum in 42%. Patient lesions were treated with 2% sertaconazole cream during a 2-week period. Clinical cure was achieved in 31% of patients after 1 week, 75% after 2 weeks, and 100% after 4 weeks. No local or systemic adverse effects were observed. It is concluded that once-daily topical sertaconazole is an effective and well-tolerated treatment for pediatric patients with dermatophytosis.
authors.affiliation: CAP Serraparera, Cerdanyola, Spain.
authors.forename: D
authors.initials: D
authors.lastname: Van Esso
authors.forename: G
authors.initials: G
authors.lastname: Fajo
authors.forename: I
authors.initials: I
authors.lastname: Losada
authors.forename: M
authors.initials: M
authors.lastname: Vilallonga
authors.forename: J M
authors.initials: JM
authors.lastname: Casanovas
authors.forename: J
authors.initials: J
authors.lastname: Clanxet
authors.forename: A
authors.initials: A
authors.lastname: Aliaga
mesh_terms: D000279:Administration, Cutaneous; D000293:Adolescent; D000935:Antifungal Agents / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D003881:Dermatomycoses / Q000188:drug therapy*; D005260:Female; D006801:Humans; D007093:Imidazoles / Q000627:therapeutic use*; D008297:Male; D013876:Thiophenes / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D013876:Thiophenes; C061131:sertaconazole