The effect of 1,25 dihydroxyvitamin D3 on lymphocyte transformation in patients with chronic renal failure.
The changes in mitogen-induced lymphocyte response occurring in nine patients undergoing chronic hemodialysis and treated with 1,25 dihydroxyvitamin D3 (0.5 micrograms/day) were investigated. Prior to treatment the stimulation indices (SI) in patients with 15.4 +/- 4.2 for phytohemagglutinin (PHA) and 7.2 +/- 0.7 for conconavalin A (Con A). In the controls, stimulation indices were 44.4 +/- 13.5 and 20.2 +/- 5.3 for PHA and Con A, respectively. Following treatment, the stimulation indices increased to 36.9 +/- 6.2 for PHA (p < 0.05) and 18.6 +/- 3.9 for Con A (p > 0.05) indicating the beneficial effect of oral 1,25 dihydroxyvitamin D3 treatment on lymphocyte function in patients with chronic renal failure.
Alpdogan
O
O
Department of Haematology and Immunology, Marmara University Hospital, Istanbul, Turkey.
Ozgun
S
S
Lawrence
R
R
Ozener
C
C
Akoglu
E
E
Akoglu
T
T
D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D002117:Calcitriol / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D016022:Case-Control Studies; D003208:Concanavalin A / Q000494:pharmacology; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000276:immunology* / Q000628:therapy; D008213:Lymphocyte Activation / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D010710:Phosphates / Q000097:blood; D010835:Phytohemagglutinins / Q000494:pharmacology; D006435:Renal Dialysis
D010710:Phosphates; D010835:Phytohemagglutinins; D003208:Concanavalin A; D002117:Calcitriol; D002118:Calcium