Acquired protein S deficiency in a patient with systemic lupus erythematosus causing central retinal vein thrombosis.
A 16 year old girl with systemic lupus erythematosus (SLE) developed the rare complication of central retinal vein occlusion. Although classically a disease of older patients, it has been recognised in association with SLE but only in the presence of the lupus anticoagulant or antiphospholipid antibodies. The thrombosis occurred when free protein S concentrations were transiently reduced and there was no family history or other known causes of reduced protein S concentrations. No other prothrombotic risk factors were present.
Prince
H M
HM
Department of Haematology, Austin Hospital, Heidelberg, Victoria, Australia.
Thurlow
P J
PJ
Buchanan
R C
RC
Ibrahim
K M
KM
Neeson
P J
PJ
D000293:Adolescent; D002352:Carrier Proteins / Q000097:blood; D015935:Complement C4b; D003169:Complement Inactivator Proteins; D005260:Female; D005500:Follow-Up Studies; D006023:Glycoproteins; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000150:complications*; D018455:Protein S Deficiency / Q000150:complications*; D012170:Retinal Vein Occlusion / Q000209:etiology*
D002352:Carrier Proteins; D003169:Complement Inactivator Proteins; D006023:Glycoproteins; D015935:Complement C4b