title: Hyperthermic stress modulates the functions of rat liver glucocorticoid receptor.
abstract: A mild whole body hyperthermic stress causes a rapid and reversible reduction of rat liver glucocorticoid receptor (GR) binding capacity and affects the stability of the GR-DNA complexes formed after thermal transformation of the receptor. These changes appear to be physiologically relevant, since they are accompanied by a decrease in dexamethasone induction of hepatic tyrosine aminotransferase (TAT). In spite of the decreased rate of the GR degradation in liver cytosol of hyperthermic as compared to control rats, the total amount of the GR and its proteolytic products recognized by BuGR2 monoclonal antibody was found to be lower in the former cytosol, but higher in the respective nuclei.
authors.affiliation: Department of Biochemistry and Molecular Biology, Institute for Biological Research, Belgrade, Yugoslavia.
authors.forename: G
authors.initials: G
authors.lastname: Matić
authors.forename: J
authors.initials: J
authors.lastname: Kipić
authors.forename: B
authors.initials: B
authors.lastname: Ristić
authors.forename: J
authors.initials: J
authors.lastname: Dundjerski
authors.forename: D
authors.initials: D
authors.lastname: Trajković
mesh_terms: D000818:Animals; D002467:Cell Nucleus / Q000378:metabolism; D003593:Cytoplasm / Q000378:metabolism; D003600:Cytosol / Q000378:metabolism; D004279:DNA, Viral / Q000494:pharmacology; D004268:DNA-Binding Proteins / Q000378:metabolism; D003907:Dexamethasone / Q000494:pharmacology; D004790:Enzyme Induction / Q000187:drug effects; D005334:Fever / Q000378:metabolism*; D015151:Immunoblotting; D008099:Liver / Q000201:enzymology / Q000648:ultrastructure*; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D011965:Receptors, Glucocorticoid / Q000502:physiology*; D013312:Stress, Physiological / Q000378:metabolism*; D014444:Tyrosine Transaminase / Q000096:biosynthesis
chemical_list: D004279:DNA, Viral; D004268:DNA-Binding Proteins; D011965:Receptors, Glucocorticoid; D003907:Dexamethasone; D014444:Tyrosine Transaminase