Resistance to the polyether ionophore antibiotic pandavir (nigericin) in two producing strains of Streptomyces.
In two pandavir (nigericin) producing strains, Streptomyces hygroscopicus 155 and Streptomyces albogriseolus 444, an enzyme activity was detected leading to inactivation of the antibiotic in the presence of ATP-Na2. Apparently, the observed inactivation is specific for the antibiotic produced by these strains. The nigericin producing strains were also found to be less permeable to pandavir than their non-producing variants.
Moncheva
P A
PA
Department of Microbiology, Sofia University, Bulgaria.
Christova
K R
KR
Ivanova
I V
IV
D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002473:Cell Wall / Q000187:drug effects; D004352:Drug Resistance, Microbial / Q000502:physiology; D007476:Ionophores / Q000378:metabolism; D008985:Monensin / Q000378:metabolism; D009550:Nigericin / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D007476:Ionophores; D008985:Monensin; D009550:Nigericin