Complement components and fibrinogen: correlations and association with previous myocardial infarction.
Serum complement levels have been found to be predictive of myocardial infarction up to 4 years before the acute event. To assess whether they are a marker of a hypercoagulable state, the serum or plasma levels of C3, C4, C3a, C4a, C1 inactivator, antithrombin III, protein S, protein C, fibrinogen and tissue plasminogen activator were measured in 31 patients with previous myocardial infarction and 33 controls (all males, 40-60 years old). C3, C4 and fibrinogen (which share the common characteristic of being acute phase proteins) were correlated and were associated with previous myocardial infarction, although this association persisted only for C4 in multivariate analysis. None of the coagulative variables directly involved in the complement system differed significantly in the two groups.
Muscari
A
A
Istituto di Patologia Speciale Medica e Metodologia Clinica, Università di Bologna, Italia.
Bozzoli
C
C
Massarelli
G
G
Puddu
G M
GM
Palareti
G
G
Legnani
C
C
D'Atena
T
T
Mazzuca
A
A
Miniero
R
R
Toscano
V
V
D000328:Adult; D000990:Antithrombin III / Q000378:metabolism; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood; D002561:Cerebrovascular Disorders / Q000097:blood; D003165:Complement System Proteins / Q000378:metabolism*; D015986:Confounding Factors, Epidemiologic; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008055:Lipids / Q000097:blood; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000097:blood* / Q000209:etiology / Q000628:therapy; D011486:Protein C / Q000378:metabolism; D017293:Protein S / Q000378:metabolism; D011863:Radioimmunoassay; D012307:Risk Factors; D010959:Tissue Plasminogen Activator / Q000097:blood
D008055:Lipids; D011486:Protein C; D017293:Protein S; D000990:Antithrombin III; D005340:Fibrinogen; D003165:Complement System Proteins; D010959:Tissue Plasminogen Activator