Absorption of indomethacin from nasal cavity in rats.
OBJECTIVE
To investigate if identical bioavailability, rapid Tmax, and Cmax of indometacin (Ind) could be achieved when Ind is administered in rats via intranasal (ina) route.


METHODS
The pharmacokinetics of Ind solution at a dosage of 3 mg.kg-1 was studied after i.v., ina, and po in rats using HPLC.


RESULTS
It showed that the time to peak (Tmax) of ina Ind 3 mg.kg-1 solution was 0.08 h, approached that after i.v. route the peak concentration (Cmax) following ina was 20.0 mg.L-1, 2.4 times higher than po dosing.


CONCLUSIONS
It demonstrated that the ina administration of Ind was superior to po in rats, and that Ind absorption through nasal mucosa was a reasonable approach at lower doses.
Huang
Z L
ZL
Department of Clinical Pharmacology, School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Kagoshima
M
M
Kagawa
E
E
Shimada
H
H
D000042:Absorption; D000281:Administration, Intranasal; D000818:Animals; D001682:Biological Availability; D007213:Indomethacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D008297:Male; D009296:Nasal Cavity / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley
D007213:Indomethacin