Antiviral agents in dermatology: current status and future prospects.
The majority of current antiviral agents have become available only during the past decade. The above mentioned antiviral drugs, especially the viral-TK-specific agents have attempted to bring antiviral therapy on par with antimicrobial therapy. The fact, that cells infected with viruses can be selected against the relatively low toxicity to the patient, highlights the present state of antiviral therapy. Since viral infection can be viewed as an integral component of the self (i.e., a condition that cannot simply be surgically eliminated), the science of medicine is turning to the components of the self to overcome such conditions. By administering immune-system-derived agents (e.g., interferons) or compounds that stimulate the immune system (e.g., adjuvants like imiquimod), previously unmanageable conditions become manageable. The future of antiviral therapy will undoubtedly be at the molecular level. With greater understanding of the virus and the immune system with which it interacts, more specific and efficacious antiviral agents will be added to the arsenal of the clinician.
Memar
O M
OM
Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston 77555, USA.
Tyring
S K
SK
D000998:Antiviral Agents / Q000627:therapeutic use*; D006801:Humans; D007136:Immunoglobulins / Q000627:therapeutic use; D016898:Interferon-alpha / Q000627:therapeutic use; D017193:Skin Diseases, Viral / Q000188:drug therapy* / Q000628:therapy; D014765:Viral Vaccines
D000998:Antiviral Agents; D007136:Immunoglobulins; D016898:Interferon-alpha; D014765:Viral Vaccines