Taste responses to the optical isomers of potassium warfarin and dipotassium glutamyl glutamate and the synergistic response to a mixture of both substances in mice.
The taste responses to the optical isomers of potassium warfarin, dipotassium glutamyl glutamate, and a mixture of both the substances in laboratory mice were studied using licking activity as an indicator of taste effectiveness. The offensive effectiveness of the optical isomers of potassium warfarin was the same. Every optical isomer of dipotassium glutamyl glutamate was avoided, the taste avoidance of dipotassium D-glutamyl D-glutamate being the strongest. The taste avoidance of potassium warfarin was greatly increased by the addition of every isomers of dipotassium glutamyl glutamate, and its cause was related to synergistic effects.
Ohnishi
M
M
Institute of Applied Biochemistry, University of Tsukuba, Ibaraki, Japan.
Sugawara
R
R
Kusano
T
T
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects*; D004151:Dipeptides / Q000737:chemistry / Q000494:pharmacology*; D004357:Drug Synergism; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D013237:Stereoisomerism; D013649:Taste / Q000187:drug effects*; D014859:Warfarin / Q000737:chemistry / Q000494:pharmacology*
D004151:Dipeptides; C094686:glutamyl-glutamic acid; D014859:Warfarin