Ribozymes: structure, characteristics and use as potential antiviral agents.
Ribozymes are RNA molecules that can cut or ligate other RNA molecules catalytically. Several different ribozymes have been studied. In this paper, the hammerhead and the hepatitis delta virus (HDV) ribozymes are described, as well as their possible use as antiviral therapy.
Bartolomé
J
J
Hepatology Unit, Fundación Jiménez Diaz, Madrid, Spain.
Madejón
A
A
Carreño
V
V
D000998:Antiviral Agents / Q000737:chemistry / Q000627:therapeutic use*; D001483:Base Sequence; D002384:Catalysis; D015195:Drug Design; D003698:Hepatitis Delta Virus / Q000737:chemistry; D006801:Humans; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D016337:RNA, Catalytic / Q000737:chemistry / Q000627:therapeutic use*; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D016337:RNA, Catalytic