title: Regional cerebral hypoperfusion in long-term type 1 (insulin-dependent) diabetic patients: relation to hypoglycaemic events.
abstract: Regional distribution of cerebral blood flow was determined semi-quantitatively with 99Tcm-HMPAO brain SPET under basal conditions in Type 1 (insulin-dependent) diabetic patients of recent onset and longer disease duration, and related to metabolic control and history of hypoglycaemic events. Long-term diabetic patients showed significantly more alterations in regional cerebral blood flow than diabetics of recent onset and healthy controls. Regional hypoperfusion, predominantly localized in the fronto-temporal cortex, was almost exclusively observed in patients with long-term diabetes. The latter finding was related to lower HbA1c levels (i.e. better metabolic control) and to the frequency of impending hypoglycaemia, but not to age of the patient, duration of diabetes or to chronic diabetes complications. The incidence of hypoperfusion was comparable in patient groups with or without a medical history of hypoglycaemic coma. However, regions of hypoperfusion were larger in the patients who had experienced hypoglycaemic coma. It is concluded that regional cerebral hypoperfusion in long-term Type 1 (insulin-dependent) diabetics, as evidenced by HMPAO-SPET can be related to the frequency and degree of hypoglycaemic events and to tight metabolic control, which is however at the expense of an increased risk of recurrent hypoglycaemia.
authors.affiliation: Department of Internal Medicine, Vrije Universiteit Brussel, Belgium.
authors.forename: B
authors.initials: B
authors.lastname: Keymeulen
authors.forename: A
authors.initials: A
authors.lastname: Jacobs
authors.forename: K
authors.initials: K
authors.lastname: de Metz
authors.forename: C
authors.initials: C
authors.lastname: de Sadeleer
authors.forename: A
authors.initials: A
authors.lastname: Bossuyt
authors.forename: G
authors.initials: G
authors.lastname: Somers
mesh_terms: D000328:Adult; D017668:Age of Onset; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000098:blood supply*; D002540:Cerebral Cortex / Q000098:blood supply; D002560:Cerebrovascular Circulation; D015331:Cohort Studies; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000000981:diagnostic imaging / Q000503:physiopathology*; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007003:Hypoglycemia / Q000453:epidemiology*; D007331:Insulin Coma / Q000453:epidemiology; D015609:Organotechnetium Compounds; D010091:Oximes; D015995:Prevalence; D011877:Radionuclide Imaging; D012016:Reference Values; D012044:Regression Analysis; D019690:Technetium Tc 99m Exametazime
chemical_list: D001786:Blood Glucose; D006442:Glycated Hemoglobin; D015609:Organotechnetium Compounds; D010091:Oximes; D019690:Technetium Tc 99m Exametazime