[Clinical value of cefmetazole and other cephamycin antibiotics].
The review is concerned with the description of the antibiotics belonging to cephamycins. The data on the chemical structure of cefmetazole and other cephamycins and the mechanisms of their action are presented. The peculiarities of the binding to penicillin-binding proteins and the stability to the action of various beta-lactamases are discussed. The spectrum of the antibacterial activity of cefmetazole against gram-positive and gram-negative aerobes and anaerobes, as well as the antibiotic pharmacokinetics is described. The literature data on the clinical efficacy of cefmetazole in the treatment of infectious diseases of various etiology and localization and the data on the drug tolerance and the incidence of adverse reactions are summarized. The indications to the use of cefmetazole and other cephamycins are substantiated.
Simada
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Institute of Medical Sciences, St. Marianna University School of Medicine, Kawasaki, Japan.
D000818:Animals; D015311:Cefmetazole / Q000009:adverse effects / Q000737:chemistry / Q000493:pharmacokinetics / Q000627:therapeutic use*; D018550:Cephalosporin Resistance; D002513:Cephamycins / Q000737:chemistry / Q000627:therapeutic use*; D006801:Humans; D008826:Microbial Sensitivity Tests; D013329:Structure-Activity Relationship
D002513:Cephamycins; D015311:Cefmetazole