Neuroprotective effect of human osteogenic protein-1 in a rat model of cerebral hypoxia/ischemia.
Possible neuroprotective actions of osteogenic protein-1 (OP-1) were evaluated in a rat model of cerebral hypoxia/ischemia. Intraperitoneal injection of 50 micrograms of OP-1 prior to bilateral carotid ligation and transient hypoxia in 12-day-old rats reduced cerebral infarct area from 44.8 +/- 3.3% in vehicle-injected controls to 29 +/- 4.9%. Treatment of 14-day-old rats with 20 micrograms of OP-1 1 h after hypoxia reduced mortality from 45% to 13%. OP-1 may represent a novel class of neuroprotective agents.
Perides
G
G
Department of Pathology, Harvard Medical School, Boston, MA 02115, USA.
Jensen
F E
FE
Edgecomb
P
P
Rueger
D C
DC
Charness
M E
ME
D000818:Animals; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D002545:Brain Ischemia / Q000188:drug therapy*; D004195:Disease Models, Animal; D000860:Hypoxia; D009504:Neutrophils; D011506:Proteins / Q000494:pharmacology*; D051381:Rats; D013696:Temperature; D016212:Transforming Growth Factor beta
C525819:BMP7 protein, human; C525821:Bmp7 protein, rat; D055419:Bone Morphogenetic Protein 7; D019485:Bone Morphogenetic Proteins; D011506:Proteins; D016212:Transforming Growth Factor beta