title: The sensitivity of high-resolution CT in detecting idiopathic pulmonary fibrosis proved by open lung biopsy. A prospective study.
abstract: OBJECTIVE
  To assess the sensitivity of high-resolution chest computed tomography (HRCT) in detecting idiopathic pulmonary fibrosis proved by biopsy specimen. To determine the degree of physiologic and pathologic abnormalities in patients with idiopathic pulmonary fibrosis who have a false-negative HRCT.
  
  
  METHODS
  Prospective 2-year study.
  
  
  METHODS
  Tertiary care university hospital.
  
  
  METHODS
  All patients with dyspnea and suspected interstitial lung disease referred to the University of Michigan for enrollment in the Idiopathic Pulmonary Fibrosis Specialized Center of Research (SCOR) protocol were included; 25 underwent open lung biopsy and formed the final study group.
  
  
  METHODS
  All patients underwent physiologic (pulmonary function, gas exchange, and exercise testing), radiologic (chest x-ray film and HRCT), and pathologic assessments (bronchoscopic and open lung biopsy). The results of HRCT were prospectively compared with results of standard pulmonary function tests, cardiopulmonary exercise testing, and open lung biopsy.
  
  
  RESULTS
  Of 25 patients who had both HRCT and open lung biopsy, 3 patients (12%) had HRCTs that demonstrated no evidence of interstitial lung disease. These three patients had less severe disease based on clinical, radiographic, and physiologic (CRP) scores, gas exchange abnormalities, and pathologic scoring of open lung biopsy specimens, compared with those with an abnormal HRCT.
  
  
  CONCLUSIONS
  We conclude that in the evaluation of patients with dyspnea and abnormal results of pulmonary function studies, a normal HRCT does not exclude early and clinically significant interstitial lung disease. In our patient population, physiologic testing was more sensitive than HRCT in detecting mild abnormalities in patients with idiopathic pulmonary fibrosis proved by biopsy specimen.
authors.affiliation: Department of Internal Medicine, University of Michigan School of Medicine, Ann Arbor, USA.
authors.forename: J B
authors.initials: JB
authors.lastname: Orens
authors.forename: E A
authors.initials: EA
authors.lastname: Kazerooni
authors.forename: F J
authors.initials: FJ
authors.lastname: Martinez
authors.forename: J L
authors.initials: JL
authors.lastname: Curtis
authors.forename: B H
authors.initials: BH
authors.lastname: Gross
authors.forename: A
authors.initials: A
authors.lastname: Flint
authors.forename: J P
authors.initials: JP
authors.lastname: Lynch
mesh_terms: D000328:Adult; D000368:Aged; D001706:Biopsy; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D011658:Pulmonary Fibrosis / Q000000981:diagnostic imaging* / Q000473:pathology* / Q000503:physiopathology; D012129:Respiratory Function Tests; D012680:Sensitivity and Specificity; D014057:Tomography, X-Ray Computed