Prevention of atherosclerosis. The potential role of antioxidants.
Evidence is increasing that oxidation of low-density lipoprotein cholesterol may be instrumental in atherogenesis. As a result, a number of studies have been undertaken to evaluate the effects of antioxidant vitamins, beta carotene, selenium, and monounsaturated fat on coronary artery disease. Results in many instances have been promising, particularly in the case of vitamin E supplements. Studies of pro-oxidants, such as iron and copper, are inconclusive at this time, and a trial to assess the value of probucol in hypercholesterolemic patients is currently under way.
Mehra
M R
MR
Ochsner Clinic, Department of Cardiology, New Orleans, LA 70121, USA.
Lavie
C J
CJ
Ventura
H O
HO
Milani
R V
RV
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000627:therapeutic use*; D001161:Arteriosclerosis / Q000378:metabolism / Q000517:prevention & control*; D001205:Ascorbic Acid / Q000627:therapeutic use; D002338:Carotenoids / Q000627:therapeutic use; D008078:Cholesterol, LDL / Q000378:metabolism; D003327:Coronary Disease / Q000378:metabolism / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic; D014810:Vitamin E / Q000627:therapeutic use; D019207:beta Carotene
D000975:Antioxidants; D008078:Cholesterol, LDL; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids; D001205:Ascorbic Acid