[Susceptibility study on urogenital Chlamydia trachomatis to 19 kinds of antibiotics].
We detected the minimal inhibitory concentrations (MIC) and minimal bacteriocidal concentrations (MBC) of 19 kinds of antibiotics against urogenital chlamydia trachomatis (CT) from sexually transmitted disease (STD) patients. The results were as follows: (1) The mean MICs of tetracycline, doxycycline, minocycline, erythromycin, josamycin, medimycin, lomexacin and ofloxacin were lower than 0.08 microgram/ml. Clindamycin was lightly inhibitant to CT. Steptomycin, cephaloradine, chloramiphonic, metronidazole, ciprofloxacin, sulfamethaxazole and trimethoprim showed no activitis to urogenital CT. (2) The values of the MICs and MBCs of the standard strains were among those of the isolated ones. Another the differences in drug susceptibility of different serovars were observed. (3) The MIC detected method is also discussed.
Bai
H
H
Department of Dermatology, First Affiliated Hospital Sun Yat-San University of Medical Sciences, Guangzhou.
Dong
J
J
Ning
B
B
D002584:Cervix Uteri / Q000382:microbiology; D002690:Chlamydia Infections; D002692:Chlamydia trachomatis / Q000187:drug effects* / Q000302:isolation & purification; D004318:Doxycycline / Q000494:pharmacology; D004917:Erythromycin / Q000494:pharmacology; D005260:Female; D006801:Humans; D007933:Leucomycins / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D008911:Minocycline / Q000494:pharmacology; D015231:Sexually Transmitted Diseases, Bacterial / Q000382:microbiology*; D013754:Tetracyclines / Q000494:pharmacology*; D014521:Urethra / Q000382:microbiology
D007933:Leucomycins; D013754:Tetracyclines; D004917:Erythromycin; D008911:Minocycline; D004318:Doxycycline