HLA typing in congenital toxoplasmosis.
HLA-A, HLA-B, HLA-C, and HLA-D typing was performed in 47 mothers of patients suffering from ocular toxoplasmosis to investigate whether an immunogenetic predisposition exists for developing congenital toxoplasmosis in their offspring. No significant association between any HLA antigen was observed in the mothers of patients with ocular toxoplasmosis, although a total absence of the HLA-B51 antigen was found in this group. HLA-A, HLA-B, and HLA-C typing was also performed in their children (52 patients with ocular toxoplasmosis), to investigate a possible relation between the severity of ocular toxoplasmosis and an eventual immunogenetic factor. In the patients with ocular toxoplasmosis an increased frequency of the HLA-Bw62 antigen was observed in correlation with severe ocular involvement.
Meenken
C
C
Department of Ophthalmo-Immunology, The Netherlands Ophthalmic Research Institute, Amsterdam.
Rothova
A
A
de Waal
L P
LP
van der Horst
A R
AR
Mesman
B J
BJ
Kijlstra
A
A
D004198:Disease Susceptibility; D005260:Female; D015234:HLA-A Antigens; D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D059949:HLA-B51 Antigen; D015793:HLA-B7 Antigen; D006650:Histocompatibility Testing; D006801:Humans; D007231:Infant, Newborn; D018445:Infectious Disease Transmission, Vertical; D012306:Risk; D014125:Toxoplasmosis, Congenital / Q000276:immunology*; D014126:Toxoplasmosis, Ocular / Q000276:immunology* / Q000635:transmission
D015234:HLA-A Antigens; C043205:HLA-A19 antigen; D015235:HLA-B Antigens; D059910:HLA-B15 Antigen; D059949:HLA-B51 Antigen; D015793:HLA-B7 Antigen; C044141:HLA-Bw62