title: Immunohistochemical demonstration of parathyroid hormone-related protein in thyroid gland of sheep.
abstract: Thyroid and parathyroid glands from normal adult sheep and sheep with vitamin D3-induced hypercalcemia were evaluated immunohistochemically for the presence of parathyroid hormone-related protein (PTHrP) and calcitonin (CT). Thyroid follicular cells, C-cells, and parathyroid chief cells stained moderately to strongly positive for PTHrP in both groups of sheep. C-cells were identified as cells positive for cytoplasmic staining of CT. Staining of C-cells for calcitonin in hypercalcemic sheep was diminished in intensity. The data demonstrated that PTHrP is present in the sheep thyroid and parathyroid glands. PTHrP may function as a local paracrine factor in these organs, but its staining intensity was not affected by the induction of hypercalcemia.
authors.affiliation: Department of Veterinary Pathobiology, Ohio State University, Columbus 43220, USA.
authors.forename: H
authors.initials: H
authors.lastname: Okada
authors.forename: C C
authors.initials: CC
authors.lastname: Capen
authors.forename: T J
authors.initials: TJ
authors.lastname: Rosol
mesh_terms: D000818:Animals; D002116:Calcitonin / Q000032:analysis; D002762:Cholecalciferol / Q000633:toxicity*; D006934:Hypercalcemia / Q000139:chemically induced / Q000378:metabolism / Q000662:veterinary*; D007124:Immunoenzyme Techniques; D007150:Immunohistochemistry; D008297:Male; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000032:analysis*; D012756:Sheep / Q000378:metabolism*; D013961:Thyroid Gland / Q000737:chemistry* / Q000473:pathology
chemical_list: D044162:Parathyroid Hormone-Related Protein; D011506:Proteins; D002762:Cholecalciferol; D002116:Calcitonin