[Beta 2-microglobulin kinetics during hemodialysis with different membranes].
Dialysers F6 (polysulphon membrane) and Altra Nova-170 (acetate cellulose-H membrane) were tested for effects on concentration of beta 2-microglobulin (beta-2 MG) in the course of hemodialysis. F6 produced a rise in beta-2 MG levels (50.0 +/- 7.7 to 59.2 +/- 9.5 mg/l). Altra Nova-170 induced no significant changes in these levels. Dialyser F6 seems to stimulate generation or release of beta-2 MG the input and output amounts of which indicate that the process may be confined to dialyser interior. On hemodialysis minute 15 a sharp fall in beta-2 MG concentrations was registered in the use of either device. This phenomenon resembles leukopenic effect of cellulose membranes. Hemodialysis kinetics of beta-2 MG is likely to depend on leukocyte activation.
Stetsiuk
E A
EA
Siniukhin
V N
VN
Danilkov
A P
AP
Shpazhnikova
N S
NS
Nikolaeva
N P
NP
Khamaganova
E G
EG
D000328:Adult; D002482:Cellulose / Q000031:analogs & derivatives; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000628:therapy; D007700:Kinetics; D008297:Male; D008567:Membranes, Artificial; D011108:Polymers; D006435:Renal Dialysis / Q000295:instrumentation*; D013450:Sulfones; D013997:Time Factors; D001613:beta 2-Microglobulin / Q000302:isolation & purification / Q000378:metabolism*
D008567:Membranes, Artificial; D011108:Polymers; D013450:Sulfones; D001613:beta 2-Microglobulin; C017662:polysulfone P 1700; C005062:acetylcellulose; D002482:Cellulose