title: Cytokine production in blood mononuclear cells from epileptic patients.
abstract: Although convulsive disorders have been associated with immune abnormalities, little is known about cytokine production in epileptic patients. We evaluated the concentrations of interleukin-1 alpha (IL-1 alpha), interleukin-1 beta (IL-1 beta), interleukin-2 (IL-2), and interleukin-6 (IL-6) secreted by peripheral blood mononuclear cells (PBMC) from epileptic patients. The PBMC collected from epileptic patients, as compared with those of a control group, showed greater production of IL-1 alpha, IL-1 beta, and IL-6 in response to in vitro stimulation with mitogen. There was no statistical difference among patients treated with different antiepileptic drugs (AEDs). Significantly greater IL-2 production was observed in PBMC from carbamazepine (CBZ)-treated patients as compared with both the control group or with valproate and phenobarbital (PB)-treated patients.
authors.affiliation: Clinical Biochemistry Department, Istituto Superiore di Sanità, Rome, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Pacifici
authors.forename: L
authors.initials: L
authors.lastname: Paris
authors.forename: S
authors.initials: S
authors.lastname: Di Carlo
authors.forename: A
authors.initials: A
authors.lastname: Bacosi
authors.forename: S
authors.initials: S
authors.lastname: Pichini
authors.forename: P
authors.initials: P
authors.lastname: Zuccaro
mesh_terms: D000293:Adolescent; D000328:Adult; D002220:Carbamazepine / Q000494:pharmacology / Q000627:therapeutic use; D016207:Cytokines / Q000096:biosynthesis*; D004827:Epilepsy / Q000188:drug therapy / Q000276:immunology*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000096:biosynthesis; D007376:Interleukin-2 / Q000096:biosynthesis; D015850:Interleukin-6 / Q000096:biosynthesis; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D008934:Mitogens; D010634:Phenobarbital / Q000494:pharmacology / Q000627:therapeutic use; D014635:Valproic Acid / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D007376:Interleukin-2; D015850:Interleukin-6; D008934:Mitogens; D002220:Carbamazepine; D014635:Valproic Acid; D010634:Phenobarbital