Increased radiosensitivity of normal tissue fibroblasts in patients with acquired immunodeficiency syndrome (AIDS) and with Kaposi's sarcoma.
Fibroblasts cultured from skin biopsies of patients with AIDS and Kaposi's sarcoma were found to be more radiosensitive than fibroblasts from non-HIV-infected-sources. This supports clinical observations of overt sensitivity to radiotherapy in some AIDS patients with Kaposi's sarcoma.
Formenti
S C
SC
Department of Radiation Oncology, University of Southern California School of Medicine, Los Angeles 90033, USA.
Chak
L
L
Gill
P
P
Buess
E M
EM
Hill
C K
CK
D000163:Acquired Immunodeficiency Syndrome / Q000276:immunology*; D002478:Cells, Cultured; D005347:Fibroblasts / Q000528:radiation effects; D006801:Humans; D011836:Radiation Tolerance; D012514:Sarcoma, Kaposi / Q000532:radiotherapy*