title: Noninvasive assessment of the intralabyrinthine pressure. A new technique applied to patients with X-linked progressive mixed deafness syndrome with perilymphatic gusher during stapes surgery.
abstract: In this report, we describe the findings of a noninvasive assessment of the intralabyrinthine pressure in two patients from a family with X-linked progressive, mixed deafness syndrome in whom a perilymphatic gusher occurs during stapes surgery. The so-called tympanic membrane displacement measurement technique could be successfully applied in these two patients (from a total of five patients who were studied) because they still showed a stapedial reflex at 1 kHz, which is mandatory for application of the tympanic membrane displacement measurement technique. The findings were compared with those of age-related control subjects and indicated a significantly elevated intralabyrinthine pressure in the two patients who were observed. The results suggest that the tympanic membrane displacement measurement technique may serve as a screening test in audiological diagnostic studies of perilymphatic hypertension.
authors.affiliation: Department of Otolaryngology, Hanover Medical School, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Ernst
authors.forename: F M
authors.initials: FM
authors.lastname: Snik
authors.forename: I A
authors.initials: IA
authors.lastname: Mylanus
authors.forename: W R
authors.initials: WR
authors.lastname: Cremers
mesh_terms: D000158:Acoustic Impedance Tests; D000328:Adult; D003638:Deafness / Q000235:genetics* / Q000503:physiopathology* / Q000601:surgery; D007758:Ear, Inner / Q000502:physiology*; D005260:Female; D008040:Genetic Linkage; D006439:Hemodynamics; D006801:Humans; D008208:Lymphatic System; D008297:Male; D011312:Pressure; D013577:Syndrome; D014960:X Chromosome