TFIIH: a link between transcription, DNA repair and cell cycle regulation.
TFIIH is a basal transcription factor for protein-coding genes. It contains ERCC2, ERCC3, MO15 and cyclin H, polypeptides implicated in nucleotide excision repair or cell cycle regulation. The dysfunction of TFIIH could result in a large panel of genetic disorders, such as xeroderma pigmentosum, Cockayne's syndrome and trichothiodystrophy. This link between transcription, DNA repair and cell cycle has highlighted a complex and essential role for TFIIH in the cell and has provided much information on the molecular mechanisms of each of these cellular processes.
Seroz
T
T
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Strasbourg, France.
Hwang
J R
JR
Moncollin
V
V
Egly
J M
JM
D002453:Cell Cycle; D003057:Cockayne Syndrome / Q000235:genetics; D004265:DNA Helicases / Q000378:metabolism*; D004260:DNA Repair; D006197:Hair / Q000002:abnormalities; D006801:Humans; D051758:Transcription Factor TFIIH; D014157:Transcription Factors / Q000378:metabolism*; D019473:Transcription Factors, TFII; D014158:Transcription, Genetic; D014983:Xeroderma Pigmentosum / Q000235:genetics
D014157:Transcription Factors; D019473:Transcription Factors, TFII; D051758:Transcription Factor TFIIH; D004265:DNA Helicases