Effect of humidity-dependent changes in crystal structure on the solid-state fluorescence properties of a new HMG-CoA reductase inhibitor.
It has been shown previously that the disodium salt of a new HMG-CoA reductase inhibitor (SQ-33600) is capable of existing as a number of hydrate species [1]. Three crystalline solid hydrates and one liquid crystalline phase have been identified, each having a definite stability over a defined range of humidity. These forms have been found to exhibit varying fluorescence properties in their respective solid states, with differences in bandshapes and intensities being noted for each. These spectral variations have been correlated with the known pseudopolymorphism of the compound.
Brittain
H G
HG
Bristol-Myers Squibb Pharmaceutical Research Institute, New Brunswick, New Jersey 08903, USA.
Ranadive
S A
SA
Serajuddin
A T
AT
D000924:Anticholesteremic Agents / Q000737:chemistry*; D003460:Crystallization; D005453:Fluorescence; D006813:Humidity; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles / Q000737:chemistry*; D009943:Organophosphorus Compounds / Q000737:chemistry*
D000924:Anticholesteremic Agents; D019161:Hydroxymethylglutaryl-CoA Reductase Inhibitors; D007211:Indoles; D009943:Organophosphorus Compounds; C066279:SQ 33600