title: Chemical and pharmacological characterization of Erythrophleum lasianthum alkaloids.
abstract: Two alkaloids 1 and 2 were isolated from the seeds of Erythrophleum lasianthum. Their structures were assigned by spectroscopic and chemical means as 3 beta-hydroxynorerythrosuamine (1) and its 3-O-beta-D-glucopyranoside (2). In spontaneously beating atria, both compounds 1 and 2 showed a marked and concentration-dependent positive inotropic activity and a weak negative chronotropic activity. The positive inotropic effect induced by 1 and 2 was not modified by propranolol, prazosin, carbachol, and ranitidine plus pyrilamine. Both 1 and 2 were very active in inhibiting the Na+/K(+)-ATPase isolated from bovine cardiac sarcolemmal vesicles.
authors.forename: L
authors.initials: L
authors.lastname: Verotta
authors.forename: T
authors.initials: T
authors.lastname: Aburjai
authors.forename: C B
authors.initials: CB
authors.lastname: Rogers
authors.forename: P
authors.initials: P
authors.lastname: Dorigo
authors.forename: I
authors.initials: I
authors.lastname: Maragno
authors.forename: D
authors.initials: D
authors.lastname: Fraccarollo
authors.forename: G
authors.initials: G
authors.lastname: Santostasi
authors.forename: R M
authors.initials: RM
authors.lastname: Gaion
authors.forename: M
authors.initials: M
authors.lastname: Floreani
authors.forename: F
authors.initials: F
authors.lastname: Carpenedo
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D007887:Fabaceae / Q000737:chemistry*; D006168:Guinea Pigs; D006325:Heart Atria; D066298:In Vitro Techniques; D008519:Medicine, Traditional; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000201:enzymology; D010042:Ouabain / Q000494:pharmacology; D008517:Phytotherapy; D010946:Plants, Medicinal; D012110:Reserpine / Q000494:pharmacology; D012508:Sarcolemma / Q000201:enzymology; D012639:Seeds / Q000737:chemistry*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013019:South Africa
chemical_list: D000470:Alkaloids; D010042:Ouabain; D012110:Reserpine; D000254:Sodium-Potassium-Exchanging ATPase