A novel serum protein similar to C1q, produced exclusively in adipocytes.
We describe a novel 30-kDa secretory protein, Acrp30 (adipocyte complement-related protein of 30 kDa), that is made exclusively in adipocytes and whose mRNA is induced over 100-fold during adipocyte differentiation. Acrp30 is structurally similar to complement factor C1q and to a hibernation-specific protein isolated from the plasma of Siberian chipmunks; it forms large homo-oligomers that undergo a series of post-translational modifications. Like adipsin, secretion of Acrp30 is enhanced by insulin, and Acrp30 is an abundant serum protein. Acrp30 may be a factor that participates in the delicately balanced system of energy homeostasis involving food intake and carbohydrate and lipid catabolism. Our experiments also further corroborate the existence of an insulin-regulated secretory pathway in adipocytes.
Scherer
P E
PE
Whitehead Institute for Biomedical Research, Cambridge, Massachusetts 02142-1479, USA.
Williams
S
S
Fogliano
M
M
Baldini
G
G
Lodish
H F
HF
D016475:3T3 Cells; D052242:Adiponectin; D000273:Adipose Tissue / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D001798:Blood Proteins / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D003001:Cloning, Molecular; D015922:Complement C1q / Q000096:biosynthesis* / Q000737:chemistry / Q000235:genetics; D007328:Insulin / Q000378:metabolism; D036341:Intercellular Signaling Peptides and Proteins; D051379:Mice; D008969:Molecular Sequence Data; D015394:Molecular Structure; D008970:Molecular Weight; D011506:Proteins; D012091:Repetitive Sequences, Nucleic Acid
D052242:Adiponectin; D001798:Blood Proteins; D007328:Insulin; D036341:Intercellular Signaling Peptides and Proteins; D011506:Proteins; D015922:Complement C1q