Influence of intraperitoneal gentamicin on peritoneal transport in IPD patients.
We have investigated the effect of intraperitoneal gentamicin on dialysis efficiency in 10 intermittent peritoneal dialysis (IPD) patients. The following parameters were measured: net ultrafiltration (UF); concentration ratios (D/P) of urea, creatinine, potassium; peritoneal clearances (ml/min) of urea, creatinine, potassium; mass transfer of sodium (MTNa); sodium sieving index (SCNa). It has been found that gentamicin significantly decreased D/P urea (p < 0.056) and D/P creatinine (p < 0.05). We found also a significant decrease of mean clearances of urea (p < 0.05) and creatinine (p < 0.05). The mean clearance of potassium did not significantly change. There was no significant change in UF, MTNa and SCNa. Our preliminary data suggest that gentamicin decreases the permeability of the peritoneum for certain low molecules in IPD patients, which may have a negative impact on dialysis efficiency.
Janicka
L
L
Department of Nephrology, Medical Academy, Lublin, Poland.
Majdan
M
M
Solski
J
J
Baranowska-Daca
E
E
Kimak
E
E
D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002908:Chronic Disease; D003404:Creatinine / Q000378:metabolism; D015314:Dialysis Solutions / Q000378:metabolism; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage* / Q000493:pharmacokinetics; D006801:Humans; D007274:Injections, Intraperitoneal; D017136:Ion Transport / Q000187:drug effects*; D007674:Kidney Diseases / Q000378:metabolism / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010530:Peritoneal Dialysis; D010537:Peritoneum / Q000187:drug effects / Q000378:metabolism*; D011188:Potassium / Q000378:metabolism; D012964:Sodium / Q000378:metabolism; D014508:Urea / Q000378:metabolism
D000900:Anti-Bacterial Agents; D015314:Dialysis Solutions; D005839:Gentamicins; D014508:Urea; D012964:Sodium; D003404:Creatinine; D011188:Potassium