Comparison of fluid volumes with whole bowel irrigation in a simulated overdose of ibuprofen.
OBJECTIVE
To determine the effect of 2 different fluid volumes of polyethylene glycol whole bowel irrigation (WBI) solution on absorption of an ingested toxin in a simulated overdose model.


METHODS
Prospective, randomized, crossover trial.


METHODS
Clinical research unit.


METHODS
Nine adult men.


METHODS
On 2 separate days, volunteers ingested approximately 75 mg/kg of ibuprofen. In treatment 1, 30 minutes after ingestion of ibuprofen, a 3-L WBI at 2 L/h was begun. This procedure was repeated in treatment 2 with an 8-L. WBI administered at 2 L/h. Fourteen timed serum samples were collected prior to and after drug ingestion for a 24-hour period and analyzed for ibuprofen concentration. The peak serum concentration, time to peak concentration, total area under the serum concentration-time curve (AUC), clearance, and volume of distribution were compared.


RESULTS
The mean +/- SD AUCs did not differ between the 3-L (1185.3 +/- 216.9 mg.h/L) and 8-L (1153.5 +/- 251.5 mg.h/L) treatments (p = 0.710). Time to peak serum concentration, peak serum concentration, clearance, and volume of distribution were comparable for the 2 treatments (p > 0.05).


CONCLUSIONS
These data indicated that a total WBI volume of 3 L would be expected to perform as well as 8 L administered at the same rate. We recommend that further research define the optimal dose of WBI in acute ingestion of toxins.
Olsen
K M
KM
Department of Pharmacy Practice, University of Nebraska Medical Center, Omaha 68198, USA.
Gurley
B J
BJ
Davis
G A
GA
Archer
S R
SR
Ma
F H
FH
Ackerman
B H
BH
D000328:Adult; D062787:Drug Overdose / Q000628:therapy; D006801:Humans; D007052:Ibuprofen / Q000378:metabolism / Q000506:poisoning*; D007422:Intestines / Q000502:physiology*; D008297:Male; D011092:Polyethylene Glycols / Q000008:administration & dosage* / Q000494:pharmacology; D011446:Prospective Studies; D007507:Therapeutic Irrigation
D011092:Polyethylene Glycols; D007052:Ibuprofen