title: A paradigm 1994: the allograft response.
abstract: This review presents our concepts regarding the mechanisms of rejection and the pathway leading to graft tolerance. Allograft rejection is a T-cell-dependent process. Accordingly, we discuss the current understanding of T cell activation and cytokine production and then apply these concepts to the mechanisms that cause rejection and tolerance. We describe the ability of renal epithelial cells to either induce T cell activation or anergy. Finally, we review potential mechanisms responsible for the maintenance of tolerance.
authors.affiliation: Department of Medicine, Harvard Medical School, Boston, Mass, USA.
authors.forename: V R
authors.initials: VR
authors.lastname: Kelley
authors.forename: T B
authors.initials: TB
authors.lastname: Strom
mesh_terms: D000818:Animals; D006084:Graft Rejection / Q000276:immunology; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D016030:Kidney Transplantation / Q000276:immunology*; D018448:Models, Immunological; D014184:Transplantation, Homologous / Q000276:immunology