[The action of neuroleptics on different types of catalepsy in rats with a genetic predisposition to catatonic reactions].
Rats of GC strain with genetic predisposition to cataleptic reactions bred from Wistar rats are more sensitive to cataleptogenic effect of haloperidol and trifluperidol than Wistar rats. At the same time, chlorpromazine and sulpiride considerably shorten the time of maintenance of imposed vertical cataleptic postures for which GC strain has been selected. This paradoxical situation is interpreted so that the more pronounced neuroleptic-induced catalepsy in GC rats is caused by increased sensitivity of postsynaptic dopamine D receptors in the striatum, while the predisposition to the cataleptic postures attenuated by neuroleptics is associated with dopaminergic hyperactivity of the mesolimbic system.
Kolpakov
V G
VG
Nikulina
E M
EM
Alekhina
T A
TA
Gevorgian
M M
MM
D000818:Animals; D014150:Antipsychotic Agents / Q000627:therapeutic use*; D002375:Catalepsy / Q000139:chemically induced / Q000188:drug therapy*; D002389:Catatonia / Q000139:chemically induced / Q000188:drug therapy*; D004198:Disease Susceptibility; D004353:Drug Evaluation, Preclinical; D008297:Male; D051381:Rats; D011919:Rats, Inbred Strains; D017208:Rats, Wistar
D014150:Antipsychotic Agents