Morphologic and morphometric study of human spiral ganglion development.
A light microscopic study of the spiral ganglion was done in human embryos and fetuses measuring 45, 50, 60, 74, 90, 134, 270 mm crown-rump length (crl), and in a one-day-old neonate. Morphometric evaluations of i) cell and nuclear area, ii) nuclear area/cell area ratio, iii) ganglion area, iv) cell concentration/surface unit, and v) distance between the first neuron and the receptor were made, and the results statistically evaluated. In earlier stages of development, spiral ganglion primordia appeared as a cluster of neuroblasts and some schwannoblasts immersed in the mesenchymal tissue, close to the ductus cochlearis. A honeycomb pattern in the spiral ganglion neurons was observed in the basal turn of a 74 mm crl fetus. In later stages, the basal turn of a 90 mm crl fetus showed a spatial organization. Peripheral and central fibers of the acoustic nerve appeared stratified in early periods of development (45 mm crl embryo). From this stage on, both phenomena progress apicalwards until the neonatal period. A significant decrease in the nuclear area/cell area ratio was observed from the 134 mm crl fetus (17 weeks) to the neonatal stage in all turns. This led to a significant increase in cellular area from the 270 mm crl fetus (32 weeks) to the neonate, with no significant variation in nuclear area. The distance from the primordium of the organ of Corti to the spiral ganglion in the interval between 45 and 74 mm crl showed a significant increase in all turns.(ABSTRACT TRUNCATED AT 250 WORDS)
Sánchez Del Rey
A
A
Otolaryngology Department, Basurto Hospital, School of Medicine, University of the Basque Country, Bilbao, Spain.
Sánchez Fernández
J M
JM
Martínez Ibarguen
A
A
Santaolalla Montoya
F
F
D003053:Cochlear Duct / Q000196:embryology; D004622:Embryo, Mammalian; D005314:Embryonic and Fetal Development; D005333:Fetus; D006801:Humans; D007231:Infant, Newborn; D009474:Neurons; D013136:Spiral Ganglion / Q000196:embryology* / Q000502:physiology / Q000648:ultrastructure*