title: Effect of hypergravity on vestibular compensation in guinea pigs.
abstract: The effect of hypergravity on vestibular compensation was studied in guinea pigs. Pharmacological labyrinthectomy was performed by injecting chloroform into the middle ear cavity under ether anesthesia. The guinea pigs were exposed to hypergravity on a centrifuge. The animals were divided into four groups: a group stimulated with 2G after labyrinthectomy of the right ear, a group stimulated with 2G after labyrinthectomy of the left ear to evaluate the influence of the centrifugal rotation, a group stimulated with acceleration and deceleration alone, and a control group which was maintained under similar conditions, but without centrifugation. Head deviation and nystagmus were recorded and analysed to assess the process of compensation at 1, 3, 5, 7 and 9 h after labyrinthectomy. The 2G-stimulated group showed faster compensation in head deviation than the control group. In this study, the hypergravity stimulation seemed to facilitate the compensation in head deviation.
authors.affiliation: Department of Otolaryngology, Yamaguchi University School of Medicine, Ube, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Ikeda
authors.forename: T
authors.initials: T
authors.lastname: Sekitani
authors.forename: H
authors.initials: H
authors.lastname: Hara
authors.forename: T
authors.initials: T
authors.lastname: Tahara
authors.forename: M
authors.initials: M
authors.lastname: Takahashi
mesh_terms: D000222:Adaptation, Physiological; D000818:Animals; D002498:Centrifugation; D002725:Chloroform / Q000494:pharmacology; D007758:Ear, Inner / Q000187:drug effects / Q000502:physiology; D006168:Guinea Pigs; D018471:Hypergravity; D014722:Vestibule, Labyrinth / Q000503:physiopathology*
chemical_list: D002725:Chloroform