Effect of praziquantel treatment on hepatic pathology of Schistosoma mansoni experimentally infected mice.
In this study we used Schistosoma mansoni (S. mansoni) infected mice were used to assess the pathological changes in the liver at various stages of the disease as well as the effectiveness of Praziquantel (PZQ) treatment on hepatic pathology also at different stages. The S. mansoni infected mice were divided into 7 groups and subgroups according to post infection and/or post treatment periods. The various hepatic pathological changes were recorded and it was concluded that PZQ is an effective yet, safe non hepatotoxic drug and that the earlier the application of treatment in the course of the disease the better cure we can get with minimal or no insult to the liver tissue.
Khalil
H M
HM
Department of Parasitology, Faculty of Medicine, Ain Shams University, Abbassia, Cairo, Egypt.
Bebars
M A
MA
el-Badawy
N M
NM
Abdallah
H M
HM
Khalil
N M
NM
el-Zayyat
E A
EA
el-Din Mohamed
M S
MS
D000818:Animals; D008099:Liver / Q000473:pathology*; D051379:Mice; D011223:Praziquantel / Q000627:therapeutic use*; D012555:Schistosomiasis mansoni / Q000188:drug therapy* / Q000473:pathology
D011223:Praziquantel