[Substituted imidazolidinediones and thiazolidinediones: synthesis, structure and cytotoxic activity].
Synthesis and physico-chemical properties of nine 3-(4-fluoro or chlorobenzyl)-5-arylidène-imidazolidine-2,4-diones, four 3-(4-fluoro or bromobenzyl)-5-arylidène-thiazolidine-2,4-diones and three 3-)4-bromophénacyl)-5-arylidène-thiazolidine-2,4- diones has been described. These compounds were synthesized by aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted imidazolidine-2,4-diones or thiazolidine-2,4-diones. In vitro cytotoxic activity was determined for compounds 8, 17, 18, 21 and 22.
Barros Costa
D L
DL
Departamento de Antibioticos, Universidade Federal de Pernambuco, Brésil.
Chantegrel
J
J
Alves de Lima
M C
MC
Cavalcanti Albuquerque
J M
JM
Correa Lima
R M
RM
Galdino
S L
SL
Pitta
I R
IR
Luu-Duc
C
C
D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D007624:KB Cells; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D007093:Imidazoles; D013844:Thiazoles