The residual anthelmintic efficacy of moxidectin against selected nematodes affecting sheep.
Determination of the residual anthelmintic efficacy in sheep of an oral formulation of moxidectin at a dosage rate of 0.2 mg kg-1 was evaluated 27-29 (mean: 28) d after dosing and that of the injectable formulation of moxidectin at a dosage rate of 0.2 mg kg-1 at 27-29 (mean: 28) and 34-36 (mean: 35) d post-treatment. The injectable formulation was more than 80% effective in more than 80% of treated sheep against a third larval stage challenge of Haemonchus contortus, Teladorsagia (Ostertagia) circumcincta, Gaigeria pachyscelis and Oesophagostomum columbianum at both 28 and 35 d post-treatment. The oral formulation on the other hand was equally effective against a third larval stage challenge of G. pachysce1is at 28 d post-treatment and more than 60% effective in more than 60% of treated sheep against a third larval stage challenge at 28 d post-treatment of H. contortus, T. circumcincta and O. columbianum.
Peter
R J
RJ
Rumevite Animal Care, Elarduspark, Republic of South Africa.
Boelema
E
E
Grové
J T
JT
Rall
M
M
D000284:Administration, Oral; D000818:Animals; D000871:Anthelmintics / Q000008:administration & dosage / Q000627:therapeutic use*; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D006189:Haemonchus / Q000187:drug effects; D007263:Infusions, Parenteral; D018942:Macrolides; D009348:Nematoda / Q000187:drug effects; D009349:Nematode Infections / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000188:drug therapy* / Q000469:parasitology
D000871:Anthelmintics; D000900:Anti-Bacterial Agents; D018942:Macrolides; C027837:moxidectin