title: Nuclear DNA ploidy pattern and tissue levels of dihydroxyphenylalanine and catecholamines in pheochromocytoma.
abstract: Flow-cytometric analysis of nuclear DNA and measurements of tissue levels of dihydroxyphenylalanine (dopa) and catecholamines were performed using fresh samples of tissue taken from 17 patients with pheochromocytoma. Nine (53%) tumors had a diploid pattern of DNA, and 8 (47%) had an aneuploid pattern. The tissue concentrations of dopa, dopamine, norepinephrine, and epinephrine did not differ significantly between pheochromocytomas with a diploid and those with an anoeuploid pattern. These results suggest that there is no correlation between nuclear DNA ploidy and tissue levels of dopa and catecholamines in pheochromocytomas.
authors.affiliation: Department of Urology, Yamagata University School of Medicine, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Sasagawa
authors.forename: T
authors.initials: T
authors.lastname: Nakada
authors.forename: Y
authors.initials: Y
authors.lastname: Kubota
authors.forename: M
authors.initials: M
authors.lastname: Ishigooka
authors.forename: T
authors.initials: T
authors.lastname: Sawamura
authors.forename: Y
authors.initials: Y
authors.lastname: Suzuki
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D002395:Catecholamines / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004273:DNA, Neoplasm / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D011003:Ploidies; D012189:Retrospective Studies
chemical_list: D002395:Catecholamines; D004273:DNA, Neoplasm; D004295:Dihydroxyphenylalanine