NCAM-antibodies modulate induction of long-term potentiation in rat hippocampal CA1.
The neural cell adhesion molecule (NCAM) probably plays a role in neural plasticity in the adult vertebrate brain. We here present evidence that NCAM may be involved in long-term potentiation (LTP) in the CA1-region of rat hippocampal slices. It is shown that local application of antibodies against NCAM inhibits subsequent LTP-induction. Thus NCAM may be directly involved in the initial phase of LTP-induction. These results have important implications for the possible involvement of NCAM in learning and memory.
Rønn
L C
LC
University of Copenhagen, Protein Laboratory, Panum Institute, Denmark.
Bock
E
E
Linnemann
D
D
Jahnsen
H
H
D015763:2-Amino-5-phosphonovalerate / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000276:immunology*; D015816:Cell Adhesion Molecules, Neuronal / Q000276:immunology / Q000502:physiology*; D004058:Diffusion; D006624:Hippocampus / Q000502:physiology*; D007150:Immunohistochemistry; D066298:In Vitro Techniques; D017774:Long-Term Potentiation / Q000502:physiology*; D008297:Male; D008845:Microinjections; D009434:Neural Pathways / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar
D000906:Antibodies; D015816:Cell Adhesion Molecules, Neuronal; D015763:2-Amino-5-phosphonovalerate