Sattabacins and sattazolins: new biologically active compounds with antiviral properties extracted from a Bacillus sp.
A series of new compounds with antiviral properties were isolated from a Bacillus sp. strain B-60. They were named sattabacin (1), hydroxysattabacin (2), sattazolin (3) and methylsattazolin (4). The biologically active compounds were recovered from fermentation broth by ethyl acetate extraction and silica-gel column fractionation. Their antiviral activity was mainly expressed against the Herpes simplex viruses type 1 and 2. The compound 3 showed a selective inhibition of protein synthesis in Herpesvirus-infected cells.
Lampis
G
G
Sezione di Microbiologia, Università di Cagliari, Italy.
Deidda
D
D
Maullu
C
C
Madeddu
M A
MA
Pompei
R
R
Delle Monachie
F
F
Satta
G
G
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001407:Bacillus; D002522:Chlorocebus aethiops; D006588:Hexanones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D018139:Simplexvirus / Q000187:drug effects; D013329:Structure-Activity Relationship; D014709:Vero Cells / Q000187:drug effects / Q000378:metabolism
D000998:Antiviral Agents; D006588:Hexanones; D007211:Indoles; C096627:methylsattazolin; C096624:sattabacin; C096626:sattazolin; C096625:hydroxysattabacin