Study of the association of HLA class I antigens with kala-azar.
HLA class I antigen frequencies were studied in 52 patients with kala-azar and compared with 222 unrelated healthy controls. The relative risk (RR) and etiologic or preventive fraction (EF/PF) were determined for each character, and statistical significance was evaluated with chi 2 with Yates' correction. Results showed that the only antigen with a statistically significant difference was HLA-A26 (15.38 vs. 1.35%; p = 0.004), with RR = 13.27 and EF = 0.142. This indicates a high risk of contracting the disease for HLA-A26-positive individuals and a relatively remarkable influence of this antigen on the prevalence rate of kala-azar.
Faghiri
Z
Z
School of Paramedical Sciences, Shiraz University of Medical Sciences, Iran.
Tabei
S Z
SZ
Taheri
F
F
D016001:Confidence Intervals; D005787:Gene Frequency; D015234:HLA-A Antigens / Q000097:blood / Q000235:genetics; D015235:HLA-B Antigens / Q000097:blood / Q000235:genetics; D015236:HLA-C Antigens / Q000097:blood / Q000235:genetics; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D007898:Leishmaniasis, Visceral / Q000453:epidemiology / Q000235:genetics* / Q000276:immunology*; D012016:Reference Values; D018570:Risk Assessment
D015234:HLA-A Antigens; D015235:HLA-B Antigens; D015236:HLA-C Antigens; D015395:Histocompatibility Antigens Class I