[Clinical usefulness of pediatric population parameter of slow-releasing preparation of sodium valproate].
We predicted the serum level of a slow-releasing preparation of sodium valproate (VPA-SR) in 9 children with epilepsy by pediatric population parameter obtained previously or by two adult parameters. The accuracy of prediction was evaluated as an absolute error standing for the difference between the measured and the predicted serum concentration in each patient. The mean absolute error (MAE) based on the pediatric population parameter was 5.5 +/- 5.2%, although MAEs from two adult parameters were 13.8 +/- 9.9 and 15.1 +/- 9.2%, respectively. Statistical analysis revealed that the pediatric population parameter was significantly more accurate for the prediction to serum concentrations. In conclusion, the pediatric population parameter was greatly useful for pharmacokinetic analysis of VPA-SR by Bayesian method in children with epilepsy.
Yasuda
K
K
Department of Pediatrics, Chiba University School of Medicine.
Sugita
K
K
Nakasa
H
H
Niimi
H
H
D000293:Adolescent; D002648:Child; D003692:Delayed-Action Preparations; D004827:Epilepsy / Q000097:blood* / Q000188:drug therapy; D005260:Female; D006801:Humans; D008297:Male; D014635:Valproic Acid / Q000493:pharmacokinetics* / Q000627:therapeutic use*
D003692:Delayed-Action Preparations; D014635:Valproic Acid