title: Renal involvement in hematological disorders: monoclonal immunoglobulins and nephropathy.
abstract: The study of monoclonal immunoglobulin-associated nephropathies is useful for analyzing the physicochemical properties of immunoglobulin components responsible for their deposition in the kidney. Notable advances include the first description of truncated heavy-chain deposition disease, characterization of protease resistance and binding properties of immunoglobulin light chains involved in myeloma-associated Fanconi's syndrome and cast nephropathy, and identification of hepatitis C virus as a plausible causative agent of the so-called essential mixed cryoglobulinemias.
authors.affiliation: Department of Nephrology, Tenon Hospital, Paris, France.
authors.forename: P M
authors.initials: PM
authors.lastname: Ronco
authors.forename: B
authors.initials: B
authors.lastname: Mougenot
authors.forename: G
authors.initials: G
authors.lastname: Touchard
authors.forename: J L
authors.initials: JL
authors.lastname: Preud'homme
authors.forename: P
authors.initials: P
authors.lastname: Aucouturier
mesh_terms: D000911:Antibodies, Monoclonal / Q000276:immunology*; D006402:Hematologic Diseases / Q000276:immunology / Q000503:physiopathology*; D006801:Humans; D007136:Immunoglobulins / Q000276:immunology*; D007668:Kidney / Q000503:physiopathology*; D007674:Kidney Diseases / Q000276:immunology* / Q000473:pathology
chemical_list: D000911:Antibodies, Monoclonal; D007136:Immunoglobulins