title: Parasympatholytic activity of psychoactive drugs in rat brain mitochondria.
abstract: Chlorpromazine, imipramine and amphetamine at a concentration of 0.66, 1.33 and 13.3 x 10(4) M in vitro inhibited acetyl cholinesterase activity by 16, 23 and 31% respectively in rat brain mitochondria. No change in enzyme activity was induced by these drugs in vivo. There is little cholinergic facilitation through acetylcholinesterase inhibition in the presence of psychoactive drugs.
authors.affiliation: Indian Institute of Chemical Biology, Calcutta, India.
authors.forename: M
authors.initials: M
authors.lastname: Nag
authors.forename: P S
authors.initials: PS
authors.lastname: Basu
authors.forename: N
authors.initials: N
authors.lastname: Nandi
mesh_terms: D000110:Acetylcholinesterase / Q000378:metabolism*; D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000201:enzymology*; D002746:Chlorpromazine / Q000494:pharmacology; D002800:Cholinesterase Inhibitors / Q000494:pharmacology*; D007099:Imipramine / Q000494:pharmacology; D018021:Lithium Chloride / Q000494:pharmacology; D008297:Male; D008928:Mitochondria / Q000187:drug effects / Q000201:enzymology*; D010276:Parasympatholytics / Q000494:pharmacology*; D011619:Psychotropic Drugs / Q000494:pharmacology*; D051381:Rats; D011919:Rats, Inbred Strains
chemical_list: D002800:Cholinesterase Inhibitors; D010276:Parasympatholytics; D011619:Psychotropic Drugs; D000661:Amphetamine; D000110:Acetylcholinesterase; D018021:Lithium Chloride; D007099:Imipramine; D002746:Chlorpromazine