title: Delayed gastric emptying as a factor in delayed postprandial glycaemic response in pregnancy.
abstract: OBJECTIVE
  To determine whether an alteration in gastric emptying contributes to an altered postprandial glycaemic response in normal pregnancy.
  
  
  METHODS
  A longitudinal study in normal pregnancy and postpartum.
  
  
  METHODS
  Teaching hospital in Sheffield.
  
  
  METHODS
  Primigravid women with uncomplicated pregnancies.
  
  
  METHODS
  Simultaneous meal tolerance and paracetamol absorption tests.
  
  
  METHODS
  1. Gastric emptying: maximum concentration (Cmax) and time to maximum concentration (Tmax) of paracetamol; 2. glycaemic response: Cmax, Tmax, and area under the curve of plasma glucose; 3. insulinaemic response: Cmax, Tmax, area under the curve of plasma insulin.
  
  
  RESULTS
  An increased, but not delayed, insulin response, and an increased initial glucose response to a test meal in the third trimester were not accompanied by any simultaneous delay in gastric emptying.
  
  
  CONCLUSIONS
  Gastric emptying does not seem to be a factor in the glycaemic response of pregnancy.
authors.affiliation: University Department of Obstetrics, Northern General Hospital, Sheffield, UK.
authors.forename: K
authors.initials: K
authors.lastname: Stanley
authors.forename: A
authors.initials: A
authors.lastname: Magides
authors.forename: M
authors.initials: M
authors.lastname: Arnot
authors.forename: C
authors.initials: C
authors.lastname: Bruce
authors.forename: C
authors.initials: C
authors.lastname: Reilly
authors.forename: A
authors.initials: A
authors.lastname: McFee
authors.forename: R
authors.initials: R
authors.lastname: Fraser
mesh_terms: D000082:Acetaminophen / Q000493:pharmacokinetics; D001786:Blood Glucose / Q000378:metabolism*; D005260:Female; D005746:Gastric Emptying / Q000502:physiology*; D006801:Humans; D007328:Insulin / Q000378:metabolism; D008137:Longitudinal Studies; D049590:Postpartum Period / Q000502:physiology*; D011247:Pregnancy / Q000378:metabolism / Q000502:physiology*
chemical_list: D001786:Blood Glucose; D007328:Insulin; D000082:Acetaminophen