Temporal coding in the guinea-pig auditory cortex as revealed by optical imaging and its pattern-time-series analysis.
The neural network structure of a guinea-pig's primary auditory cortex is estimated by applying pattern-time-series analysis to the auditory evoked responses. Spatiotemporal patterns in click-evoked responses, observed by optical recording with voltage-sensitive dye, are analyzed by time series analysis using a multivariable autoregressive (MAR) model. Oscillatory neural activities with a distribution of about 10 approximately 40 Hz in the click-induced evoked responses are found in the cortical response field. The cortical regions where the distributed neural oscillations are generated are identified by pattern-time-series analysis. In addition, two types of cortico-cortical connections, unilateral and bilateral connections between the cortical points, are speculated to be the causes of oscillatory neural activity transfer. It can be said that the so-called synchronized neural oscillation, in the sense of coherency or correlation between the two evoked responses at the oscillatory frequency, does not necessarily represent real cortico-cortical neural connections at the evoked response points.
Fukunishi
K
K
Advanced Research Laboratory, Hitachi Ltd., Saitama, Japan.
Murai
N
N
D000818:Animals; D001303:Auditory Cortex / Q000502:physiology*; D001306:Auditory Pathways / Q000502:physiology; D004396:Coloring Agents / Q000493:pharmacokinetics; D005072:Evoked Potentials, Auditory / Q000502:physiology*; D006168:Guinea Pigs; D008297:Male; D008433:Mathematics; D055095:Optics and Photonics / Q000295:instrumentation*; D010507:Periodicity; D013997:Time Factors
D004396:Coloring Agents