Concurrent reduction of inflammation and spinal Fos-LI neurons by systemic diclofenac in the rat.
Intraplantar carrageenan induced a peripheral inflammation and c-Fos like immunoreactivity (Fos-LI) in the dorsal horn, L4-L5 segments, of the rat spinal cord. The total number of control carrageenan evoked Fos-LI neurons was 126 +/- 6 per section, which were predominately located in the superficial and deep laminae (41 +/- 2% and 39 +/- 2% of the total number of Fos-LI neurons per section) of the dorsal horn. Pre-administered diclofenac (3, 6, 9 mg/kg i.v.) dose dependently reduced the number of Fos-LI neurons, with effects being strongest on the deep laminae Fos-LI neurons. The effects of diclofenac (9 mg/kg) on the number of Fos-LI neurons (68 +/- 2% reduction) and inflamed ankle (72 +/- 7% reduction) and paw (49 +/- 6% reduction) diameters, were positively correlated.
Buritova
J
J
Physiopharmacologie du Système Nerveux, INSERM U.161, Paris, France.
Honoré
P
P
Chapman
V
V
Besson
J M
JM
D000818:Animals; D002351:Carrageenan; D004008:Diclofenac / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D015870:Gene Expression; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D007275:Injections, Intravenous; D008297:Male; D009474:Neurons / Q000737:chemistry / Q000187:drug effects*; D016760:Proto-Oncogene Proteins c-fos / Q000032:analysis / Q000187:drug effects* / Q000235:genetics; D051381:Rats; D017207:Rats, Sprague-Dawley; D013116:Spinal Cord / Q000166:cytology; D013997:Time Factors
D016760:Proto-Oncogene Proteins c-fos; D004008:Diclofenac; D002351:Carrageenan