Workshop on perinatal exposure to dioxin-like compounds. III. Endocrine effects.
Studies involving endocrine effects in humans and experimental animals resulting from the exposure to dioxin-like (non-ortho-substituted PCBs, PCDDs/PCDFs) and nondioxin-like (PCBs, OC pesticides) compounds (DLCs and NDLCs) were presented. A variety of reproductive and hormonal parameters, including androgen status, sexual differentiation, and thyroid functionality, were discussed. As in utero and lactational exposure of the human fetus/neonate to these environmental contaminants is inevitable, continued research to identify sensitive biomarkers of effect and susceptibility, as well as to define dose-response relationships, is required.
Feeley
M M
MM
Bureau of Chemical Safety, Health and Welfare Canada, Tunney's Pasture, Ottawa, Ontario.
D000818:Animals; D005260:Female; D005333:Fetus / Q000187:drug effects*; D006801:Humans; D000072317:Polychlorinated Dibenzodioxins / Q000633:toxicity*; D011247:Pregnancy; D012733:Sex Differentiation / Q000187:drug effects; D013961:Thyroid Gland / Q000187:drug effects* / Q000502:physiology
D000072317:Polychlorinated Dibenzodioxins