title: Synthesis, characterization, and crystal structure of [Cu(cinoxacinate)2].2H2O complex: a square-planar CuO4 chromophore. Antibacterial studies.
abstract: The structural and spectroscopic properties of a new copper (II) complex of cinoxacin (HCx) have been investigated. The complex [Cu(Cx)2].2H2O crystallizes in the monoclinic system, space group P2(1)/c. The cell dimensions are: a = 7.998(2), b = 7.622(1), c = 18.955(6) A, beta = 94.38(2) degree, V = 1154.6(6) A3, Z = 2. The structure was refined to R = 0.051. The crystal is composed of [Cu(Cx)2] units and uncoordinated water molecules. The Cu(II) ion, at a center of symmetry, is coordinated to two cinoxacinate (Cx) ligands related by the inversion center. Each cinoxacinate acts as bidentate ligand bonded to the cation through its carboxylate oxygen atom and through its exocyclic carbonyl oxygen atom, resulting in a CuO4 chromophore in a crystallographically planar configuration. The complex was screened for its activity against several bacteria, showing the same antimicrobial activity as the corresponding ligand.
authors.affiliation: Departamento de Química Inorgánica, Facultad de Farmacia, Universidad de Valencia, Burjassot, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Ruiz
authors.forename: L
authors.initials: L
authors.lastname: Perelló
authors.forename: R
authors.initials: R
authors.lastname: Ortiz
authors.forename: A
authors.initials: A
authors.lastname: Castiñeiras
authors.forename: C
authors.initials: C
authors.lastname: Maichle-Mössmer
authors.forename: E
authors.initials: E
authors.lastname: Cantón
mesh_terms: D002937:Cinoxacin / Q000031:analogs & derivatives* / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D003300:Copper / Q000737:chemistry* / Q000494:pharmacology; D018360:Crystallography, X-Ray; D004578:Electron Spin Resonance Spectroscopy; D004755:Enterobacteriaceae / Q000187:drug effects; D006088:Gram-Negative Aerobic Bacteria / Q000187:drug effects; D006095:Gram-Positive Cocci / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D009942:Organometallic Compounds / Q000138:chemical synthesis / Q000737:chemistry* / Q000494:pharmacology; D012995:Solubility; D013054:Spectrophotometry, Atomic; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D009942:Organometallic Compounds; C096135:bis(cinoxacinate)copper(II); D003300:Copper; D002937:Cinoxacin