Hyperprolactinemia after treatment of long-acting gonadotropin-releasing hormone analogue Decapeptyl in girls with central precocious puberty.
OBJECTIVE
To clarify the effects of prolonged treatment with long-acting GnRH analogue on serum PRL levels.


METHODS
Blood PRL levels were measured at 9 A.M. every 28 days for a period of 6 months.


METHODS
Pediatric Endocrine Clinic, Hasharon Hospital, Petah Tiqva, Israel.


METHODS
Thirteen girls with idiopathic central precocious puberty.


RESULTS
Hyperprolactinemia developed in 5 of 13 girls after treatment with long-acting GnRH-a; mean blood PRL in all 13 girls rose significantly from 11.9 +/- 5.6 to 21.5 +/- 12.5 micrograms/L (mean +/- SD).


CONCLUSIONS
The mechanism of hyperprolactinemia in our patients is unclear. It may have resulted from a decline in the release of the hypothalamic PRL inhibitory factor. Clinically, transient hyperprolactinemia during long-acting GnRH-a treatment for central precocious puberty also may reflect a constant depression of LH secretion.
Kauschansky
A
A
Department of Obstetrics and Gynecology, Hasharon Hospital, Petah Tiqva, Israel.
Nussinovitch
M
M
Frydman
M
M
Yeshaya
A
A
Ben-Rafael
Z
Z
D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced*; D007223:Infant; D011629:Puberty, Precocious / Q000188:drug therapy*; D017329:Triptorelin Pamoate / Q000009:adverse effects*
D017329:Triptorelin Pamoate