title: Secretoneurin in bronchopulmonary carcinoids--immunohistochemical comparison with chromogranins A and B and secretogranin II.
abstract: Ninety-nine classical and 11 atypical bronchopulmonary carcinoids were investigated immunohistochemically with an antibody against secretoneurin, a peptide proteolytically processed from secretogranin II (chromogranin C), as well as antibodies against chromogranin A and B and secretogranin II. Secretoneurin was immunolocalized in 86 tumours (78 classical and eight atypical carcinoids); secretogranin II was found in the same tumours in a similar distribution, whereas chromogranin A was present in all 100 and chromogranin B in 106 tumours investigated. Bronchopulmonary carcinoids are usually not associated with clinically or biochemically distinct syndromes. Although we found bronchial carcinoids with different immunohistochemical chromogranins/secretogranin patterns, no correlation with the biological behaviour of these tumours could be demonstrated.
authors.affiliation: Department of Pathology, University of Münster, Germany.
authors.forename: M
authors.initials: M
authors.lastname: Tötsch
authors.forename: B C
authors.initials: BC
authors.lastname: Padberg
authors.forename: S
authors.initials: S
authors.lastname: Schröder
authors.forename: D
authors.initials: D
authors.lastname: Ofner
authors.forename: W
authors.initials: W
authors.lastname: Böcker
authors.forename: R
authors.initials: R
authors.lastname: Fischer-Colbrie
authors.forename: K W
authors.initials: KW
authors.lastname: Schmid
mesh_terms: D002276:Carcinoid Tumor / Q000737:chemistry*; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry*; D009479:Neuropeptides / Q000032:analysis*; D011506:Proteins / Q000032:analysis*; D053381:Secretogranin II
chemical_list: D053379:Chromogranin A; D002864:Chromogranins; D009479:Neuropeptides; D011506:Proteins; D053381:Secretogranin II; C081159:secretoneurin