A comparative analysis of fall in haemoglobin following abortions conducted by mifepristone (600 mg) and vacuum aspiration.
We compared post-abortion metrorrhagia in 185 women who used the mifepristone (600 mg) plus sulprostone (250 micrograms) drug combination and in 196 women who underwent vacuum aspiration. The patients were monitored for a 2 week period, with haemoglobin being measured on the day of the abortion and 2 weeks later. The women who had used the drug combination experienced a mean fall of 0.7 g/dl in haemoglobin (36% lost > 1 g/dl and 8% > 2 g/dl); haemoglobin concentrations remained stable in women who had had vacuum aspiration.
Thonneau
P
P
French National Institute of Health and Medical Research (INSERM), Unit 292, Hôpital de Bicêtre, Le Kremlin-Bicêtre.
Poirel
H
H
Fougeyrollas
B
B
Maria
B
B
Meyer
L
L
Goepp
A
A
Hercberg
S
S
Spira
A
A
D000021:Abortifacient Agents, Steroidal / Q000627:therapeutic use*; D000028:Abortion, Induced / Q000379:methods*; D015232:Dinoprostone / Q000031:analogs & derivatives* / Q000627:therapeutic use; D004338:Drug Combinations; D005260:Female; D006454:Hemoglobins / Q000378:metabolism*; D006801:Humans; D008796:Metrorrhagia / Q000209:etiology*; D015735:Mifepristone / Q000627:therapeutic use*; D015999:Multivariate Analysis; D011247:Pregnancy; D013396:Suction; D014618:Vacuum
D000021:Abortifacient Agents, Steroidal; D004338:Drug Combinations; D006454:Hemoglobins; D015735:Mifepristone; C016767:sulprostone; D015232:Dinoprostone