An unwanted side effect of hydroxyurea in a patient with idiopathic myelofibrosis.
A patient with idiopathic myelofibrosis is reported who developed a drug fever after treatment with hydroxyurea, a generally effective and well-tolerated drug in chronic myeloproliferative syndromes. Typically, this form of fever develops after a few weeks of exposure to the drug and disappears with discontinuation of the drug. Possible interactions with prostaglandin or leukotriene metabolism may play a role.
Starmans-Kool
M J
MJ
Department of Internal Medicine, De Wever Hospital, Heerlen, The Netherlands.
Fickers
M M
MM
Pannebakker
M A
MA
D000368:Aged; D005334:Fever / Q000139:chemically induced*; D006801:Humans; D006918:Hydroxyurea / Q000009:adverse effects*; D008297:Male; D055728:Primary Myelofibrosis / Q000188:drug therapy*
D006918:Hydroxyurea