gamma-Aminobutyric acidA receptor function is modulated by cyclic GMP.
Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the vertebrate nervous system. Modulatory effects of intracellular ATP on the GABA response in isolated bullfrog dorsal root ganglion neurons were examined using whole-cell voltage clamp. Investigation of the plausible mechanisms ATP might utilize to regulate the GABA response led to the discovery that intracellular cyclic GMP may play an important role in modulating inhibitory neurotransmission. This modulatory effect of cyclic GMP is likely to be mediated via a cyclic GMP-dependent protein kinase.
Bradshaw
D J
DJ
Department of Pharmacology, Marshall University School of Medicine, Huntington, WV 25704-9388, USA.
Simmons
M A
MA
D000255:Adenosine Triphosphate / Q000502:physiology*; D000704:Analysis of Variance; D000818:Animals; D006152:Cyclic GMP / Q000502:physiology*; D005727:Ganglia, Spinal / Q000166:cytology / Q000502:physiology*; D006160:Guanosine Triphosphate / Q000502:physiology; D007700:Kinetics; D009475:Neurons, Afferent / Q000502:physiology*; D018408:Patch-Clamp Techniques; D011892:Rana catesbeiana; D011963:Receptors, GABA-A / Q000502:physiology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology
D011963:Receptors, GABA-A; D005680:gamma-Aminobutyric Acid; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate; D006152:Cyclic GMP