Primary non-Hodgkin's lymphoma of the vagina. Case report and review of the literature.
The genital tract as primary site of malignant non-Hodgkin's lymphoma in women is extremely rare, whereas secondary involvement in advanced disease is found in about 40% of cases. In this report a patient is presented who had a primary vaginal non-Hodgkin's lymphoma of the centroblastic type according to the Kiel classification, with an excellent response to cytotoxic chemotherapy (CHOP) and event-free disease for 3 years. A review of the literature shows that favorable prognosis of localized disease seems to be a common experience. Primary involvement of the vagina can be successfully treated by pelvic irradiation, but in young women cytotoxic chemotherapy should be considered to preserve fertility.
Höffkes
H G
HG
Division of Hematology, Department of Medicine, University of Essen, Germany.
Schumann
A
A
Uppenkamp
M
M
Teschendorf
C
C
Schindler
A E
AE
Parwaresch
R
R
Brittinger
G
G
D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000188:drug therapy / Q000473:pathology*
D000970:Antineoplastic Agents