Biochemical parameters in BAL of sarcoisosis.
Sarcoidosis can be presented to the physician as an active or silent disorder, which may resolve or lead to pulmonary fibrosis. Various serum or bronchoalveolar lavage fluid (BAL) markers have been suggested when trying to find one marker or a combination of markers which could be representative of the disease. The aim of the study was to evaluate a number of biochemical markers in comparison to cellular parameters in BAL of 45 patients with active or inactive sarcoidosis, as well as in 44 patients with other disorders and of 10 healthy volunteers. Moreover, in order to get insight into ACE activity in different compartments, ACE values in BAL and serum were compared. In active sarcoidosis BAL-procollagen-III-peptide was significantly increased in contrast to the very low values in inactive disease. In healthy volunteers procollagen-III-peptide levels were below the detection limit. In BAL no significant differences were found for beta-2-microglobulin, hyaluronan or ACE. Laminin in BAL was not detectable. Serum ACE, significantly enhanced in sarcoidosis, was not discriminative between active and inactive disease.


CONCLUSIONS
only procollagen-III-peptide in BAL was found to discriminate between active and inactive disease. Besides cell differentiation and T-helper/suppressor cell (CD4/CD8) ratio in BAL, no further biochemical parameters pointing to disease or activity of disease were found.
Straub
J P
JP
Department of Clinical Chemistry, Free University Hospital, Amsterdam, The Netherlands.
van Kamp
G J
GJ
van Maarsseveen
T C
TC
Stam
J
J
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001706:Biopsy; D001992:Bronchoalveolar Lavage Fluid / Q000737:chemistry*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005260:Female; D006801:Humans; D006820:Hyaluronic Acid / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D007703:Peptidyl-Dipeptidase A / Q000378:metabolism*; D011347:Procollagen / Q000378:metabolism*; D017565:Sarcoidosis, Pulmonary / Q000378:metabolism*; D001613:beta 2-Microglobulin / Q000378:metabolism*
D011347:Procollagen; D001613:beta 2-Microglobulin; D006820:Hyaluronic Acid; D007703:Peptidyl-Dipeptidase A