[Induction of endogenous anti-IgE antibody of nasal mucosa and its inhibitive effects on IgE level].
The animals were immunized with IgEFc epsilon fraction which conjugated with keyhole limpet hemocyanin locally and systemically. The levels of anti-IgE, IgE and other four kinds of immunoglobulins were tested from the specimen of nasal mucosa, blood and spleen. The results showed that there were enhanced anti-IgE levels and depressed IgE levels, and there were no significant changes in the other four kinds of immunoglobulins after being immunized with IgEFc epsilon fractions. These effects continued until 14 weeks after immunization. These data demonstrate that there are possibilities to induce anti-IgE antibody in nasal mucosa locally and inhibit IgE antibody without significant side effects on the body.
Yang
P
P
First Affiliated Hospital, Shanxi Medical College, Taiyuan.
Li
X
X
D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000378:metabolism*; D000921:Antibody-Producing Cells / Q000276:immunology; D005260:Female; D007073:Immunoglobulin E / Q000378:metabolism*; D007141:Immunoglobulin Fc Fragments / Q000276:immunology; D051379:Mice; D008807:Mice, Inbred BALB C; D009297:Nasal Mucosa / Q000276:immunology*; D012221:Rhinitis, Allergic, Perennial / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D007141:Immunoglobulin Fc Fragments; D007073:Immunoglobulin E