title: Initiation of signal transduction by receptor aggregation: role of nonreceptor tyrosine kinases.
abstract: Receptors which induce immune system effector function bear similar intracellular sequences and respond to aggregation through a nonreceptor tyrosine kinase-dependent pathway. The mechanism by which receptor aggregation leads to cell activation is poorly understood, but recent experiments with chimeric receptors and kinases have begun to simplify the analysis.
authors.affiliation: Massachusetts General Hospital, Boston 02114, USA.
authors.forename: B
authors.initials: B
authors.lastname: Seed
mesh_terms: D018801:CD2 Antigens / Q000276:immunology / Q000378:metabolism; D002678:Chimera; D004789:Enzyme Activation / Q000276:immunology; D004792:Enzyme Precursors / Q000276:immunology / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D017261:Glycosylphosphatidylinositols / Q000276:immunology / Q000378:metabolism; D047908:Intracellular Signaling Peptides and Proteins; D008213:Lymphocyte Activation; D015688:Oncogene Protein pp60(v-src) / Q000276:immunology / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000276:immunology / Q000378:metabolism / Q000502:physiology*; D011940:Receptor Aggregation / Q000276:immunology*; D011947:Receptors, Antigen, B-Cell / Q000276:immunology / Q000378:metabolism; D011948:Receptors, Antigen, T-Cell / Q000276:immunology / Q000378:metabolism; D015398:Signal Transduction / Q000276:immunology*; D000072377:Syk Kinase; D051746:ZAP-70 Protein-Tyrosine Kinase
chemical_list: D018801:CD2 Antigens; D004792:Enzyme Precursors; D017261:Glycosylphosphatidylinositols; D047908:Intracellular Signaling Peptides and Proteins; D011947:Receptors, Antigen, B-Cell; D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases; D015688:Oncogene Protein pp60(v-src); D000072377:Syk Kinase; D051746:ZAP-70 Protein-Tyrosine Kinase