title: [Effect of pefloxacin on luminol-dependent chemiluminescence and leukocyte adhesion].
abstract: The in vitro action of pefloxacin on the luminole-dependent chemiluminescence and adherence of polymorphonuclear leukocytes of guinea pigs was studied within a wide range of the concentrations from 0.1 to 100 micrograms/ml. Pefloxacin did not influence the peak values of the chemiluminescence while in concentrations of 0.1 to 10 micrograms/ml it retarded its attenuation. After incubation of the leukocytes in the presence of 100 micrograms/ml of pefloxacin and the subsequent washing out the drug there was observed a decrease in the chemiluminescence. In concentrations of 0.1 to 100 micrograms/ml pefloxacin had no significant effect on the leukocyte adherence.
authors.forename: T V
authors.initials: TV
authors.lastname: Smolkina
authors.forename: A I
authors.initials: AI
authors.lastname: Iordanova
authors.forename: S M
authors.initials: SM
authors.lastname: Iudin
authors.forename: A V
authors.initials: AV
authors.lastname: Nikitin
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002478:Cells, Cultured; D006168:Guinea Pigs; D006801:Humans; D008163:Luminescent Measurements; D008165:Luminol; D009503:Neutropenia / Q000188:drug therapy; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects*; D015366:Pefloxacin / Q000009:adverse effects / Q000494:pharmacology*
chemical_list: D015366:Pefloxacin; D008165:Luminol