Are the 'core' proteins of the mitochondrial bc1 complex evolutionary relics of a processing protease?
The so-called 'core' proteins of the respiratory cytochrome bc1 complex and the two subunits of the mitochondrial processing peptidase (MPP) are structurally similar but their evolutionary relationship remains a mystery. Here, we present a model suggesting that the core proteins originated from an ancient proteolytic enzyme that was integrated into the bc1 complex during early stages of endosymbiosis.
Braun
H P
HP
Institut für Genbiologische Forschung GmbH, Berlin, Germany.
Schmitz
U K
UK
D000595:Amino Acid Sequence; D000818:Animals; D005075:Biological Evolution; D006801:Humans; D008666:Metalloendopeptidases / Q000737:chemistry*; D008969:Molecular Sequence Data; D009245:NADH Dehydrogenase / Q000737:chemistry*; D000096122:Mitochondrial Processing Peptidase
D008666:Metalloendopeptidases; D009245:NADH Dehydrogenase; D000096122:Mitochondrial Processing Peptidase