title: [Organic psychosyndrome and sleep apnea. Transdermal nicotine--a new therapy concept?].
abstract: We examined 11 patients (10 female, 1 male) of 73 to 79 years of age suffering from organic psychosyndrome (HOPS), using the apnoea screen system MESAM IV (1) and APNOE-SCREEN I. All examined patients had a sleep related disordered breathing (SBAS) with apnoea index (AI) between 10 and 52 (P/h). 3 patients (2 female, 1 male) had an increasing apnoea index under medication of theophyllin 375 mg/d. these theophyllin-nonresponsive patients received transdermal Nicotin in a concentration of 21 mg/d (during the night). The apnoea index decreased not significantly, while the tiredness was reduced significantly by 42.9%, the confusion by 40% and the nightly restlessness by 50%.
authors.affiliation: Facharzt für Innere Medizin, Alfed/L.
authors.forename: J A
authors.initials: JA
authors.lastname: Wirth
mesh_terms: D000279:Administration, Cutaneous; D000368:Aged; D003704:Dementia / Q000150:complications / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests; D009538:Nicotine / Q000008:administration & dosage*; D012891:Sleep Apnea Syndromes / Q000150:complications / Q000188:drug therapy*
chemical_list: D009538:Nicotine