Functional mapping of the human somatosensory cortex with echo-planar MRI.
The somatotopical organization of the human somatosensory cortex was analyzed with echo-planar imaging at 1.5 Tesla, utilizing deoxyhemoglobin as an endogenous contrast medium. Scrubbing stimulation at a frequency of 3 Hz was applied to one of three cutaneous areas: toes, fingertips, and tongue tip. Parasagittal echo-planar slices were obtained every 2 s. We found focal bands of increased signal intensity (4% on average) during the stimulation, with a rise time of 2-6 s. These activated bands were located on the contralateral postcentral gyrus. The cortical responses from the three stimulation sites were anatomically distinct and organized medially-to-laterally in the order of toes, fingertips, and tongue tip.
Sakai
K
K
Department of Physiology, School of Medicine, University of Tokyo, Japan.
Watanabe
E
E
Onodera
Y
Y
Itagaki
H
H
Yamamoto
E
E
Koizumi
H
H
Miyashita
Y
Y
D000328:Adult; D001931:Brain Mapping / Q000379:methods*; D017352:Echo-Planar Imaging / Q000379:methods*; D006801:Humans; D012677:Sensation / Q000502:physiology; D013003:Somatosensory Cortex / Q000033:anatomy & histology / Q000502:physiology*