Nuclear DNA ploidy pattern and tissue levels of dihydroxyphenylalanine and catecholamines in pheochromocytoma.
Flow-cytometric analysis of nuclear DNA and measurements of tissue levels of dihydroxyphenylalanine (dopa) and catecholamines were performed using fresh samples of tissue taken from 17 patients with pheochromocytoma. Nine (53%) tumors had a diploid pattern of DNA, and 8 (47%) had an aneuploid pattern. The tissue concentrations of dopa, dopamine, norepinephrine, and epinephrine did not differ significantly between pheochromocytomas with a diploid and those with an anoeuploid pattern. These results suggest that there is no correlation between nuclear DNA ploidy and tissue levels of dopa and catecholamines in pheochromocytomas.
Sasagawa
I
I
Department of Urology, Yamagata University School of Medicine, Japan.
Nakada
T
T
Kubota
Y
Y
Ishigooka
M
M
Sawamura
T
T
Suzuki
Y
Y
D000310:Adrenal Gland Neoplasms / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D000328:Adult; D000368:Aged; D002395:Catecholamines / Q000378:metabolism*; D002467:Cell Nucleus / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D004273:DNA, Neoplasm / Q000378:metabolism*; D004295:Dihydroxyphenylalanine / Q000378:metabolism*; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D010673:Pheochromocytoma / Q000378:metabolism* / Q000473:pathology / Q000601:surgery; D011003:Ploidies; D012189:Retrospective Studies
D002395:Catecholamines; D004273:DNA, Neoplasm; D004295:Dihydroxyphenylalanine