Treatment of Legionella pneumophila lung abscess with clindamycin.
Clindamycin was used to successfully treat a lung abscess caused by Legionella pneumophila. The activity of clindamycin, erythromycin, and rifampin against cell-associated growth of L. pneumophila in human monocytes was determined by broth time-kill methodology. More killing of cell-associated growth of L. pneumophila was achieved with clindamycin than with erythromycin. Synergy with rifampin was demonstrated with both erythromycin and clindamycin.
Buggy
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BP
Department of Medicine, St. Luke's Medical Center, Milwaukee, Wisconsin, USA.
Saravolatz
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D000328:Adult; D002981:Clindamycin / Q000627:therapeutic use*; D006801:Humans; D016952:Legionella pneumophila / Q000187:drug effects; D007877:Legionnaires' Disease / Q000188:drug therapy*; D008169:Lung Abscess / Q000188:drug therapy*; D008297:Male; D008826:Microbial Sensitivity Tests
D002981:Clindamycin