Axial movements of rat mandibular incisors measured under artificial respiration with halothane anaesthesia.
The axial movements of rat incisors were recorded continuously for over 20 h. The rats were anaesthetized with halothane delivered by intratracheal intubation using an artificial respirator. A haemostatic clamp was used to immobilize the jaw and the displacement detector exhibited high resolution, good linearity and low drift. The previously impeded and unimpeded eruption rates (the average extrusive movements) were 406 and 548 microns/24 h, respectively. The previously unimpeded rate was lower than the normal unimpeded rates obtained by other investigators. It appears that the eruptive movement of the previously unimpeded incisor was inhibited by halothane anaesthesia. Circadian rhythm was not observed in the eruption rates of previously impeded or unimpeded incisors. Following the i.p. injection of a lethal dose of pentobarbital sodium, the incisors retracted. The average intrusive movement was significantly greater in the previously impeded group (29 microns) than in the previously unimpeded group (12 microns) at 30 min after the lethal injection. It is assumed that the elimination of the pushing force at death may cause the stretched periodontal fibres to recoil, thereby pulling the tooth in an intrusive direction. It is also likely that the mechanical strength of the ligament is reduced in the previously unimpeded group by repeated shortening of the incisors; therefore the force needed to retract previously unimpeded incisors may be less than that needed to retract previously impeded incisors.
Chiba
M
M
Department of Pharmacology, School of Dental Medicine, Tsurumi University, Yokohama, Japan.
Komatsu
K
K
Yamaguchi
S
S
D000818:Animals; D003799:Dental Stress Analysis; D006221:Halothane / Q000009:adverse effects*; D008297:Male; D010424:Pentobarbital / Q000494:pharmacology; D010513:Periodontal Ligament / Q000187:drug effects / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012121:Respiration, Artificial; D014078:Tooth Eruption / Q000187:drug effects / Q000502:physiology*
D010424:Pentobarbital; D006221:Halothane