title: Prognostic significance of ST-segment depression during adenosine perfusion imaging.
abstract: To determine the significance of ST-segment depression during adenosine perfusion imaging for predicting future cardiac events, 188 patients with interpretable electrocardiograms were assessed 1 to 3 years (mean 21.5 +/- 6.6 months) after adenosine testing. At least 1 mm of ST-segment depression was observed in 32 (17%) patients, with > or = 2 mm of ST-segment depression in 10 (5.3%). Thirty-seven cardiac events occurred during the study period: 2 cardiac deaths, 5 nonfatal myocardial infarctions, 6 admissions for unstable angina, and 24 revascularizations. Univariate predictors of events were a history of congestive heart failure, previous non-Q-wave myocardial infarction, previous coronary angioplasty, use of antianginal medication, ST-segment depression during adenosine infusion (particularly > or = 2 mm), any reversible perfusion defect, transient left ventricular cavity dilation, and the severity of perfusion defects. Multivariate analysis identified > or = 2 mm ST-segment depression as the most significant predictor of cardiac events (relative risk [RR] = 6.5; p = 0.0001). Other independent predictors of events were left ventricular dilation (RR = 3.8; p = 0.002), previous coronary angioplasty (RR = 3.3; p = 0.001), a history of non-Q-wave myocardial infarction (RR = 2.3; p = 0.01), and the presence of any reversible defect (RR = 2.0; p = 0.05). We conclude that ST-segment depression occurs uncommonly during adenosine infusion, but the presence of > or = 2 mm of ST-segment depression is an independent predictor of future cardiac events and provides information in addition to that obtained from clinical variables and the results of adenosine perfusion imaging.
authors.affiliation: Division of Cardiology, Thomas Jefferson University Hospital, Philadelphia, PA 19107, USA.
authors.forename: E S
authors.initials: ES
authors.lastname: Marshall
authors.forename: J S
authors.initials: JS
authors.lastname: Raichlen
authors.forename: S M
authors.initials: SM
authors.lastname: Kim
authors.forename: C M
authors.initials: CM
authors.lastname: Intenzo
authors.forename: D T
authors.initials: DT
authors.lastname: Sawyer
authors.forename: E A
authors.initials: EA
authors.lastname: Brody
authors.forename: D A
authors.initials: DA
authors.lastname: Tighe
authors.forename: C H
authors.initials: CH
authors.lastname: Park
mesh_terms: D000241:Adenosine / Q000008:administration & dosage; D000368:Aged; D016009:Chi-Square Distribution; D003327:Coronary Disease / Q000175:diagnosis; D003331:Coronary Vessels / Q000000981:diagnostic imaging; D004562:Electrocardiography / Q000187:drug effects* / Q000379:methods / Q000706:statistics & numerical data; D005080:Exercise Test / Q000379:methods / Q000706:statistics & numerical data; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D016013:Likelihood Functions; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D016016:Proportional Hazards Models; D011877:Radionuclide Imaging; D017256:Technetium Tc 99m Sestamibi; D013794:Thallium Radioisotopes; D013997:Time Factors
chemical_list: D013794:Thallium Radioisotopes; D017256:Technetium Tc 99m Sestamibi; D000241:Adenosine