title: Infectious crystalline keratopathy following trabeculectomy and low-dose topical steroids.
abstract: A case of infectious crystalline keratopathy in a patient who had undergone trabeculectomy without 5-fluorouracil is described. Chronic low-dose topical steroids were employed. Crystalline keratopathy occurring in this setting has not been previously described. A 73-year-old diabetic women presented with feathery crystal-like corneal infiltrates. These were cultured and treated with antibiotics based on the sensitivities. The cultures showed a nutritional variant of Streptococcus that was difficult to grow on routine culture plates. It was sensitive to vancomycin. Resolution of the infection occurred with topical treatment. Infectious crystalline keratopathy is a rare but classical corneal infection. The microbiological characteristics that give rise to its clinical appearance and laboratory characteristics are discussed. A rationale for diagnosis and treatment is suggested.
authors.affiliation: Department of Ophthalmology, University of Toronto, Ontario, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Apel
authors.forename: I
authors.initials: I
authors.lastname: Campbell
authors.forename: D S
authors.initials: DS
authors.lastname: Rootman
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000900:Anti-Bacterial Agents; D003315:Cornea / Q000187:drug effects / Q000382:microbiology; D003318:Corneal Opacity / Q000188:drug therapy / Q000382:microbiology; D003924:Diabetes Mellitus, Type 2 / Q000150:complications; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D015818:Eye Infections, Bacterial / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D005901:Glaucoma / Q000601:surgery; D006801:Humans; D007634:Keratitis / Q000188:drug therapy / Q000382:microbiology*; D008826:Microbial Sensitivity Tests; D009883:Ophthalmic Solutions; D011239:Prednisolone / Q000008:administration & dosage*; D013290:Streptococcal Infections / Q000188:drug therapy / Q000209:etiology*; D013291:Streptococcus / Q000187:drug effects / Q000302:isolation & purification; D014130:Trabeculectomy / Q000009:adverse effects*
chemical_list: D000900:Anti-Bacterial Agents; D009883:Ophthalmic Solutions; D011239:Prednisolone