Structure determination of MS-444; a new myosin light chain kinase inhibitor.
MS-444 is a novel myosin light chain kinase inhibitor, isolated from the culture broth of Micromonospora sp. KY7123. The structure of MS-444 was determined to be 5,8-dihydroxy-3-methyl-(9H)-naphtho[2,3-c]furan-4-one by means of spectral analysis.
Aotani
Y
Y
Tokyo Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Japan.
Saitoh
Y
Y
D005663:Furans / Q000737:chemistry* / Q000494:pharmacology; D015394:Molecular Structure; D009219:Myosin-Light-Chain Kinase / Q000037:antagonists & inhibitors*; D009284:Naphthols / Q000737:chemistry* / Q000494:pharmacology; D013057:Spectrum Analysis
D005663:Furans; D009284:Naphthols; C096620:5,8-dihydroxy-3-methyl-4-(9H)-naphtho(2,3-c)furanone; D009219:Myosin-Light-Chain Kinase