Progressive interstitial lung disease in a 75 year old woman.
The case of a 75 year old woman with rapidly progressive interstitial lung disease is presented. Bronchoalveolar lavage (BAL) was consistent with CD8+ cell alveolitis, and computerized tomography revealed features of bronchiolitis obliterans organizing pneumonia (BOOP). The patient had been on clomipramine (a tricyclic antidepressant) for 9 months prior to the onset of disease. Cessation of the drug and very short-term oral corticosteroid treatment (prematurely terminated by the patient) resulted in complete resolution of clinical symptoms, morphological and physiological findings, which remained stable without treatment over the following year. A possible drug reaction to clomipramine presenting as BOOP is discussed.
Kummer
F
F
Second Medical and Lung Dept, Wilhelminenspital der Stadt Wien, Vienna.
Salzmann
H
H
Wieckowski
A
A
D000368:Aged; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D018414:CD8-Positive T-Lymphocytes / Q000473:pathology; D002997:Clomipramine / Q000009:adverse effects; D018549:Cryptogenic Organizing Pneumonia / Q000139:chemically induced / Q000175:diagnosis*; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000209:etiology; D005260:Female; D006801:Humans; D014057:Tomography, X-Ray Computed
D002997:Clomipramine