In vivo induction of apoptosis by influenza virus.
Intranasal exposure of mice to influenza virus led to cell death in bronchial/bronchiolar epithelial cells, alveolar cells and lymphoid cells. These cells displayed fragmentation of nuclei and chromatin condensation. Nick end-labelling of DNA in situ confirmed that such apoptotic cells had fragmented DNA. These results suggest that the influenza virus induces apoptosis in vivo.
Mori
I
I
Department of Microbiology, Fukui Medical School, Japan.
Komatsu
T
T
Takeuchi
K
K
Nakakuki
K
K
Sudo
M
M
Kimura
Y
Y
D000818:Animals; D017209:Apoptosis; D001980:Bronchi / Q000473:pathology*; D002843:Chromatin / Q000502:physiology; D004249:DNA Damage; D004848:Epithelium / Q000473:pathology; D006801:Humans; D009980:Influenza A virus / Q000502:physiology*; D007251:Influenza, Human / Q000473:pathology* / Q000821:virology; D008168:Lung / Q000473:pathology*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D013950:Thymus Gland / Q000473:pathology*; D013997:Time Factors
D002843:Chromatin