title: [A case of Guillain-Barré syndrome with ophthalmoplegia showing high titers of anti-GQ1b and -GD1b antibodies in the serum].
abstract: A 24-year-old housewife developed double vision, tingling sensation, and weakness in the legs following a flu-like illness. She then developed dysphagia and difficulty in standing. On admission her eyes were fixed in midline due to ophthalmoplegia. Doll's eye sign was negative. She had severe generalized muscle weakness and no sensory deficits. All tendon reflexes were lost. CSF protein was 58 mg/dl with cell count of 2/mm3. Antibodies to campylobacter jejuni, mycoplasma, EBV, and other microbes were negative. We treated her with plasmapheresis after which she showed rapid clinical recovery, although the ophthalmoplegia improved slightly later. Increased titer of IgG class antibodies to GD1b and to GQ1b, and of IgM antibody to GQ1b, were detected in the serum taken during the acute phase of the illness. In parallel with clinical amelioration, both the anti-GD1b and -GQ1b antibodies decreased in titer, or became negative. Since there is no common epitope to GD1b and GQ1b gangliosides, we speculated that the anti-GD1b and -GQ1b antibodies were induced independently by different antigens in this patient. Moreover, the presence of high titer IgM antibody to GQ1b possible indicates that this patient was at the relatively early stage of infection of unknown microbe, which then induced the IgG antibodies to GD1b and GQ1b by cross sensitization, which might correlate with the tetraplegia and the ophthalmoplegia, respectively.
authors.affiliation: Third Department of Medicine, Hirosaki University School of Medicine.
authors.forename: R
authors.initials: R
authors.lastname: Hishida
authors.forename: M
authors.initials: M
authors.lastname: Baba
authors.forename: I
authors.initials: I
authors.lastname: Ozaki
authors.forename: M
authors.initials: M
authors.lastname: Matsunaga
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
mesh_terms: D000328:Adult; D005260:Female; D005732:Gangliosides / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007075:Immunoglobulin M / Q000097:blood*; D009886:Ophthalmoplegia / Q000209:etiology*; D011129:Polyradiculoneuropathy / Q000209:etiology*
chemical_list: D005732:Gangliosides; D007074:Immunoglobulin G; D007075:Immunoglobulin M; C033851:ganglioside, GD1b; C039129:GQ1b ganglioside