title: Direct high-performance liquid chromatographic separation of the enantiomers of methoxy and hydroxy derivatives of 3,4-dihydro-3-(dipropylamino)-2H-1-benzopyrans with dopaminergic activity.
abstract: The direct HPLC resolution of the enantiomers of methoxy and hydroxy derivatives of 3,4-dihydro-3-(dipropylamino)-2H-1-benzopyrans and of unsubstituted amino compounds was achieved using Chiralcel OD and/or Chiralpak AD stationary phases. The position of the substituent (methoxyl or hydroxyl) in the aromatic ring has a strong effect on the enantioselectivity. Circular dichroism spectra of the single enantiomers of one compound were measured.
authors.affiliation: Dipartimento di Scienze Chimiche, Università di Catania, Italy.
authors.forename: S
authors.initials: S
authors.lastname: Caccamese
authors.forename: G
authors.initials: G
authors.lastname: Principato
authors.forename: M C
authors.initials: MC
authors.lastname: Viaud
authors.forename: G
authors.initials: G
authors.lastname: Guillaumet
mesh_terms: D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid / Q000379:methods*; D002942:Circular Dichroism; D018491:Dopamine Agonists; D006900:Hydroxylation; D008745:Methylation; D013237:Stereoisomerism
chemical_list: D001578:Benzopyrans; D018491:Dopamine Agonists