Antibiotic GE37468 A: a new inhibitor of bacterial protein synthesis. I. Isolation and characterization.
GE37468 A is a new thiazolyl peptide antibiotic obtained by fermentation of Streptomyces sp. strain ATCC 55365. It inhibits bacterial protein synthesis by acting on elongation factor Tu and is structurally and functionally related to the GE2270 class of EF-Tu inhibitors. It is active in vitro against Gram-positive bacteria and Bacteroides fragilis, and protects mice against Staphylococcus aureus infection.
Stella
S
S
Marion Merrell Dow Research Institute, Lepetit Research Center, Gerenzano VA, Italy.
Montanini
N
N
Le Monnier
F
F
Ferrari
P
P
Colombo
L
L
Marinelli
F
F
Landini
P
P
Ciciliato
I
I
Goldstein
B P
BP
Selva
E
E
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D001412:Bacillus subtilis / Q000187:drug effects / Q000378:metabolism; D001426:Bacterial Proteins / Q000096:biosynthesis; D001441:Bacteroides fragilis / Q000187:drug effects; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006094:Gram-Positive Bacteria / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051379:Mice; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology; D051381:Rats; D013203:Staphylococcal Infections / Q000188:drug therapy; D013302:Streptomyces; D013844:Thiazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology
D000900:Anti-Bacterial Agents; D001426:Bacterial Proteins; C096599:GE 37468 A; D010456:Peptides, Cyclic; D013844:Thiazoles; C068122:GE 2270 A