title: Macroscopic assessment of pulmonary emphysema by image analysis.
abstract: OBJECTIVE
  To propose a computerised image analysis based method for measuring, on paper mounted lung sections, the area macroscopically occupied by emphysema.
  
  
  METHODS
  The study was based on the assessment of 69 lung sections prepared following a modified Gough-Wentworth technique. The results obtained from image analysis, point counting, and panel grading methods were compared, as was the repeatability of image analysis and panel grading.
  
  
  RESULTS
  The results from image analysis and from point counting were not significantly different (p = 0.609) and significant quadratic regressions (r = 0.96, p < 0.001) were found between measurements from image analysis and from panel grading, the computerised technique being shown to be the most reproducible.
  
  
  CONCLUSIONS
  Image analysis is a valuable and reproducible method to measure the area of lung macroscopically involved by emphysema.
authors.affiliation: Department of Radiology, Hôpital Erasme, Brussels, Belgium.
authors.forename: P A
authors.initials: PA
authors.lastname: Gevenois
authors.forename: J
authors.initials: J
authors.lastname: Zanen
authors.forename: V
authors.initials: V
authors.lastname: de Maertelaer
authors.forename: P
authors.initials: P
authors.lastname: De Vuyst
authors.forename: P
authors.initials: P
authors.lastname: Dumortier
authors.forename: J C
authors.initials: JC
authors.lastname: Yernault
mesh_terms: D016591:Histocytological Preparation Techniques; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods*; D008168:Lung / Q000473:pathology*; D011656:Pulmonary Emphysema / Q000473:pathology*; D015203:Reproducibility of Results