title: [The ethanol elimination pharmacokinetics--the effects of genotypes of ALDH2 and CYP2E1 on the ethanol metabolism].
abstract: The effect of CYP2E1 upon the blood ethanol level was investigated. Blood ethanol concentrations in 4 volunteers whose ADH 2, ADH 3 and ALDH 2 genotypes were identical, were determined after intravenous administrations of 0.20 g/kg of ethanol by gas chromatography. The predicting 95% confidence bounds determined on regression analysis of these data suggested that after venous injection of ethanol, the blood ethanol concentration in a volunteer normal homozygous for CYP2E1 (C1/C1) is higher than that heterozygous (C1/C2). And beta 60 (the blood ethanol concentration-time curve) of the subject heterozygous for CYP2E1 (C1/C2) was higher than that normal homozygous (C1/C1). It is possible that the C2 allele corresponding to the higher CYP2E1 activity may affect the ethanol metabolism.
authors.affiliation: Department of Neuropsychiatry, Kagawa Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Iwahashi
authors.forename: R
authors.initials: R
authors.lastname: Miyatake
authors.forename: K
authors.initials: K
authors.lastname: Nakamura
authors.forename: H
authors.initials: H
authors.lastname: Suwaki
authors.forename: H
authors.initials: H
authors.lastname: Kinoshita
authors.forename: K
authors.initials: K
authors.lastname: Ameno
authors.forename: I
authors.initials: I
authors.lastname: Ijiri
authors.forename: Y
authors.initials: Y
authors.lastname: Ishikawa
authors.forename: H
authors.initials: H
authors.lastname: Yoneyama
authors.forename: T
authors.initials: T
authors.lastname: Mendori
mesh_terms: D000444:Aldehyde Dehydrogenase / Q000235:genetics*; D003577:Cytochrome P-450 Enzyme System / Q000235:genetics*; D000431:Ethanol / Q000493:pharmacokinetics*; D005838:Genotype; D006801:Humans
chemical_list: D000431:Ethanol; D003577:Cytochrome P-450 Enzyme System; D000444:Aldehyde Dehydrogenase