Induction of an interleukin-1 receptor antagonist-like component produced from mouse spleen cells by bovine kappa-caseinoglycopeptide.
Bovine kappa-caseinoglycopeptide (residues 106-169, CGP) bound to mouse plastic-adherent cells. A culture supernatant prepared from mouse spleen cells and plastic-adherent cells cultured with CGP significantly inhibited the lipopolysaccharide-induced proliferative response of mouse spleen lymphocytes. The inhibition of proliferation by the culture supernatant was completely overcome by the addition of the anti-interleukin-1 receptor antagonist antibody.
Otani
H
H
Division of Animal Science, Faculty of Agriculture, Shinshu University, Nagano, Japan.
Monnai
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M
D000818:Animals; D002364:Caseins / Q000494:pharmacology*; D002417:Cattle; D002455:Cell Division; D002478:Cells, Cultured; D006020:Glycopeptides / Q000494:pharmacology*; D053590:Interleukin 1 Receptor Antagonist Protein; D051379:Mice; D008809:Mice, Inbred C3H; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors*; D012795:Sialoglycoproteins / Q000096:biosynthesis*; D013154:Spleen / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism
D002364:Caseins; D006020:Glycopeptides; C507764:Il1rn protein, mouse; D053590:Interleukin 1 Receptor Antagonist Protein; D017472:Receptors, Interleukin-1; D012795:Sialoglycoproteins; C094310:kappa-caseinoglycopeptide