Localization of PURA, the gene encoding the sequence-specific single-stranded-DNA-binding protein Pur alpha, to chromosome band 5q31.
Pur alpha (PurA) is a sequence-specific single-stranded-DNA-binding protein implicated in control of both DNA replication and transcription. We have localized the Pur alpha gene (PURA) to human chromosome band 5q31 by fluorescence in situ hybridization with a 16-kb genomic probe together with hybridization of a cDNA probe to blots of DNA from human-hamster cell lines containing individual human chromosomes. Sequences with homology to the PURA locus are also present at 6q14. The 5q31 locus is frequently deleted in myelogenous leukemia and other cancers.
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Department of Pathology, Mount Sinai School of Medicine, New York, NY 10029, USA.
Pejovic
T
T
Najfeld
V
V
Ward
D C
DC
Johnson
E M
EM
D000818:Animals; D002874:Chromosome Mapping; D002895:Chromosomes, Human, Pair 5; D006224:Cricetinae; D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins / Q000235:genetics*; D006367:HeLa Cells; D006801:Humans; D006822:Hybrid Cells; D021382:Protein Sorting Signals; D014157:Transcription Factors
D017362:Cyclic AMP Response Element-Binding Protein; D004268:DNA-Binding Proteins; C501130:PURA protein, human; D021382:Protein Sorting Signals; D014157:Transcription Factors