[Examination on aspirin-induced asthma and hypersensitivity to steroids--a questionnaire to 850 asthma on hypersensitivity to non-steroidal anti-inflammatory drugs and hypersensitivity to steroids].
We surveyed 850 patients with bronchial asthma and investigated such clinical features as the frequency of aspirin-induced asthma and hypersensitivity to steroids in the 457 available answers. We divided them into two groups, one was ASN: the asthmatics who had history of hypersensitivity to non-steroidal anti-inflammatory drugs, another was non-ASN: the asthmatics who had no history of hypersensitivity to non-steroidal anti-inflammatory drugs, and compared the two groups. The survey showed that the frequency of ASN was 12.0%. Its frequency rose with the severity of asthma to a level of 29.0% in severe cases. In ASN it was more frequent rates of female, infectious type, severe cases, and ASN had more frequent histories of oral use of steroids, use of ambulance, treatment in emergency rooms, and hospitalization than non-ASN. The serum IgE level was lower in ASN. The patients were 6 in ASN, none in non-ASN who had histories of hypersensitivity to steroids. They were 1.3% in all patients. 5 of 6 had past asthma attack progressived severely by rapid injection of succinate ester steroids and 2 of 6 had past by rapid injection of phosphoric acid ester steroids. In conclusion it was considered that we had to avoid rapid injection of steroids to aspirin-induced asthma and severe cases who were doubtful of aspirin-induced asthma in case of treatment of asthma attack.
Enomoto
T
T
First Department of Internal Medicine, Showa University School of Medicine.
Okada
T
T
Ichihashi
K
K
Horikoshi
S
S
Matsuura
T
T
Imai
T
T
Mita
S
S
Adachi
M
M
Miura
Y
Y
D000328:Adult; D000893:Anti-Inflammatory Agents / Q000009:adverse effects*; D001241:Aspirin / Q000009:adverse effects*; D001249:Asthma / Q000139:chemically induced*; D002648:Child; D002675:Child, Preschool; D000075202:Contraindications; D004342:Drug Hypersensitivity; D004804:Eosinophils; D005260:Female; D006801:Humans; D007073:Immunoglobulin E; D007223:Infant; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D013256:Steroids; D011795:Surveys and Questionnaires
D000893:Anti-Inflammatory Agents; D013256:Steroids; D007073:Immunoglobulin E; D001241:Aspirin