Genetic estimates for plasma lipids and lipoproteins in cynomolgus monkeys under assortative mating.
Data obtained from cynomolgus monkeys selected for total plasma cholesterol (TPC) response to dietary cholesterol and nonselected controls were used to estimate heritability of TPC and lipoprotein concentrations. A total of 345 observations were collected on 57 progeny from 18 sires. Heritability estimates obtained by a paternal half-sib analysis and by regression of offspring on mid-parent values were 0.45 +/- 0.24 and 0.69 +/- 0.18 for TPC, 0.63 +/- 0.30 and 0.64 +/- 0.17 for LDLC, and 0.80 +/- 0.36 and 0.59 +/- 0.14 for HDLC, respectively. These results suggest that TPC and lipoprotein concentrations are influenced by additive genetic effects in cynomolgus monkeys, establishing their importance as an animal model for studying the genetics of lipoproteins.
Spray
B J
BJ
Department of Public Health Sciences, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157, USA.
Morgan
T M
TM
Clarkson
T B
TB
D000704:Analysis of Variance; D000818:Animals; D001947:Breeding; D002784:Cholesterol / Q000097:blood*; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D008076:Cholesterol, HDL / Q000097:blood*; D008078:Cholesterol, LDL / Q000097:blood*; D005260:Female; D008137:Longitudinal Studies; D008252:Macaca fascicularis / Q000097:blood / Q000235:genetics*; D008297:Male; D012044:Regression Analysis; D015203:Reproducibility of Results
D002791:Cholesterol, Dietary; D008076:Cholesterol, HDL; D008078:Cholesterol, LDL; D002784:Cholesterol