Antibodies to intercellular adhesion molecule-1 ameliorate the inflammatory response in acetic acid-induced inflammatory bowel disease.
The transendothelial migration of leukocytes in many inflammatory responses is now believed to be dependent on the interaction of leukocyte and endothelial cell-derived adhesion molecules. To examine the role of intercellular adhesion molecule-1 (ICAM-1) in the development of inflammation in a rat model of colitis, we investigated the effects of antibodies to rat ICAM-1 given 24 hrs after inflammation was induced by acetic acid. Antibodies to rat ICAM-1 substantially ameliorated the inflammatory response as indicated by a reduction in gross inflammatory characteristics, tissue/body weight ratio, myeloperoxidase activity and superoxide levels. The results demonstrate that ICAM-1 plays an important role in the development of inflammatory bowel disease in rats. The use of antibodies to ICAM-1 to inhibit the adherence of leukocytes to endothelium, may be of potential therapeutic value in the treatment of inflammatory bowel disease in man.
Wong
P Y
PY
Department of Cell Biology, University of Medicine and Dentistry New Jersey, Stratford, USA.
Yue
G
G
Yin
K
K
Miyasaka
M
M
Lane
C L
CL
Manning
A M
AM
Anderson
D C
DC
Sun
F F
FF
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D000906:Antibodies / Q000276:immunology; D001835:Body Weight; D002465:Cell Movement; D015212:Inflammatory Bowel Diseases / Q000139:chemically induced / Q000209:etiology* / Q000473:pathology; D018799:Intercellular Adhesion Molecule-1 / Q000276:immunology / Q000502:physiology*; D008297:Male; D009504:Neutrophils / Q000166:cytology; D009929:Organ Size; D051381:Rats; D017207:Rats, Sprague-Dawley; D017382:Reactive Oxygen Species
D000085:Acetates; D000906:Antibodies; D017382:Reactive Oxygen Species; D018799:Intercellular Adhesion Molecule-1; D019342:Acetic Acid