Cytogenetic aspects of Werner's syndrome lymphocyte cultures.
Lymphocyte cultures from five patients with Werner's syndrome (WS) and five healthy controls revealed significantly slower proliferation kinetics in four out of five patients. Higher frequencies of chromosome aberration and aneuploidy were also present with evidence of variegated translocation mosaicism in one of the patients. The study revealed no differences in sister chromatid exchange frequencies.
Melaragno
M I
MI
Disciplina de Genética, Escola Paulista de Medicina, São Paulo, Brazil.
Pagni
D
D
Smith
M A
MA
D000328:Adult; D000782:Aneuploidy; D002455:Cell Division; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009030:Mosaicism; D012854:Sister Chromatid Exchange; D014898:Werner Syndrome / Q000235:genetics*