Chromosomal localization of the gene encoding the human DNA helicase RECQL and its mouse homologue.
We have determined the chromosomal location of the human and mouse genes encoding the RECQL protein, a putative DNA helicase homologous to the bacterial DNA helicase, RecQ. RECQL was localized to human chromosome 12 by analysis of human-rodent somatic cell hybrid DNA; fine mapping of RECQL by fluorescence in situ hybridization revealed its chromosomal location to be 12p11-p12. The corresponding mouse gene, Recql, was mapped to the telomeric end of mouse chromosome 6 by analysis of DNA from an interspecific cross.
Puranam
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KL
Howard Hughes Medical Institute Laboratories, Department of Medicine and Biochemistry, Duke University Medical Center, Durham, North Carolina 27710, USA.
Kennington
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E
Sait
S N
SN
Shows
T B
TB
Rochelle
J M
JM
Seldin
M F
MF
Blackshear
P J
PJ
D000251:Adenosine Triphosphatases / Q000235:genetics*; D000818:Animals; D002874:Chromosome Mapping; D002881:Chromosomes, Human, Pair 12; D004265:DNA Helicases / Q000235:genetics*; D008040:Genetic Linkage; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D051379:Mice; D008809:Mice, Inbred C3H; D053484:RecQ Helicases
D000251:Adenosine Triphosphatases; C506731:RECQL4 protein, human; D004265:DNA Helicases; D053484:RecQ Helicases