title: Levels of soluble intercellular adhesion molecule 1, eicosanoids and cytokines in ascites of patients with liver cirrhosis, peritoneal cancer and spontaneous bacterial peritonitis.
abstract: The levels of the eicosanoids leukotriene B4, prostaglandin E2, prostacycline and thromboxane B2, the cytokines interleukin-1 beta, interleukin-6 and tumour necrosis factor-alpha and soluble intercellular adhesion molecule 1 were measured in ascites and plasma samples of patients with liver cirrhosis (53), peritoneal cancer (26) and spontaneous bacterial peritonitis (10) to assess their value as a possible diagnostic and prognostic parameter in the course of the disease. Soluble intercellular adhesion molecule 1, of the eicosanoids prostaglandin E2 and leukotriene B4, and the protein concentration in ascites were all significantly elevated in ascites of patients with peritoneal cancer in comparison to ascites of patients with liver cirrhosis. In ascites of patients with spontaneous bacterial infection interleukin-6 concentration was significantly elevated and the protein concentration was significantly lower in comparison to the other two groups. None of these parameters, however, seems to be of practical use as a diagnostic parameter, as there is an overlap between all the levels of these mediators in ascites of liver cirrhosis, peritoneal cancer and spontaneous bacterial peritonitis group. Soluble intercellular adhesion molecule 1 levels were much higher in plasma than in ascites, in contrast to interleukin-6 levels which were much higher in ascites than in plasma. Soluble intercellular adhesion molecule 1 in ascites correlated with soluble intercellular adhesion molecule 1 in plasma (r = 0.6926, P = 0.0001). Soluble intercellular adhesion molecule 1, interleukin-6 and the number of polymorphonuclear cells in peritoneal fluid correlated during episodes of infection in patients with a peritonitis. For this reason soluble intercellular adhesion molecule 1 and interleukin-6 could be of prognostic value for patients with peritonitis.
authors.affiliation: Department of Pharmacology, Erasmus University, Rotterdam, The Netherlands.
authors.forename: W M
authors.initials: WM
authors.lastname: Pruimboom
authors.forename: D J
authors.initials: DJ
authors.lastname: Bac
authors.forename: A P
authors.initials: AP
authors.lastname: van Dijk
authors.forename: I M
authors.initials: IM
authors.lastname: Garrelds
authors.forename: C J
authors.initials: CJ
authors.lastname: Tak
authors.forename: I L
authors.initials: IL
authors.lastname: Bonta
authors.forename: J H
authors.initials: JH
authors.lastname: Wilson
authors.forename: F J
authors.initials: FJ
authors.lastname: Zijlstra
mesh_terms: D000328:Adult; D000368:Aged; D001201:Ascites / Q000175:diagnosis / Q000378:metabolism*; D001424:Bacterial Infections / Q000378:metabolism / Q000382:microbiology; D015331:Cohort Studies; D016207:Cytokines / Q000097:blood / Q000378:metabolism*; D003956:Dialysis; D015777:Eicosanoids / Q000097:blood / Q000378:metabolism*; D005260:Female; D006801:Humans; D007118:Immunoassay; D007249:Inflammation / Q000378:metabolism / Q000473:pathology; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010534:Peritoneal Neoplasms / Q000097:blood / Q000378:metabolism*; D010538:Peritonitis / Q000097:blood / Q000175:diagnosis / Q000378:metabolism* / Q000382:microbiology; D011379:Prognosis; D011506:Proteins / Q000032:analysis; D013223:Statistics as Topic; D013997:Time Factors
chemical_list: D016207:Cytokines; D015777:Eicosanoids; D011506:Proteins; D018799:Intercellular Adhesion Molecule-1