title: Use of simple clinical signs to predict pneumonia in young Gambian children: the influence of malnutrition.
abstract: The current WHO recommendations for the case management of acute respiratory infections (ARI) in children aged 2 months to 5 years in developing countries use fast breathing (respiratory rate of > or = 50 per minute in children under 12 months and > or = 40 in children aged 12 months to 5 years) and lower chest wall indrawing to determine which child is likely to have pneumonia and should therefore receive antibiotics. We have evaluated these and other physical signs in 487 malnourished children and 255 well nourished children who presented with a cough or breathing difficulty. Pneumonia, defined as definite radiological pneumonia or probable radiological pneumonia associated with crackles on auscultation, was present in 145 (30%) of the malnourished children and 68 (26%) of the well nourished children. The respiratory rate predicted pneumonia equally well in the two groups, but to achieve an appropriate sensitivity and specificity the respiratory rate cut-off required in malnourished children was approximately 5 breaths per minute less than that in well nourished children. Intercostal indrawing was more common and lower chest wall indrawing was less common in the malnourished children, with or without pneumonia. These results suggest that fast breathing, as defined at present by WHO, and lower chest wall indrawing are not sufficiently sensistive as predictors of pneumonia in malnourished children. As the latter are a high-risk group, we should like to recommend that children with malnutrition who present with a cough, fast breathing or difficult breathing should be treated with antibiotics.
authors.affiliation: Medical Research Council Laboratories, Banjul The Gambia.
authors.forename: A G
authors.initials: AG
authors.lastname: Falade
authors.forename: H
authors.initials: H
authors.lastname: Tschäppeler
authors.forename: B M
authors.initials: BM
authors.lastname: Greenwood
authors.forename: E K
authors.initials: EK
authors.lastname: Mulholland
mesh_terms: D015362:Child Nutrition Disorders / Q000150:complications*; D002675:Child, Preschool; D005714:Gambia; D006801:Humans; D007223:Infant; D011014:Pneumonia / Q000175:diagnosis* / Q000209:etiology; D011237:Predictive Value of Tests; D012680:Sensitivity and Specificity