[Effects of glucocorticoid therapy on mineral metabolism indicators in patients with bronchial asthma].
Magnesium and calcium levels in the serum, red cells, lymphocytes, circadian urine and exhaled air condensate were measured in 40 patients with hormone-dependent bronchial asthma (BA) and 15 BA patients receiving glucocorticoids in inhalations (beclamete, becotide) and injections (hydrocortisone, prednisolone, dexasone). Nuclear absorption spectrophotometry (AAC-508, Hitachi, Japan) and selective ionometry (Mycrolyte, Kone, Finland) were employed. Short-term (10-14 days) intravenous infusions and inhalations of steroids in medium therapeutic doses do not change much homeostasis of two-valent cations. Complications resultant from disturbance of mineral metabolism developed more frequently in BA patients on long-term (4 years more longer) oral glucocorticoids. Increased renal and bronchial excretion of magnesium and calcium in patients with hormone-dependent BA having complications of glucocorticoid therapy suggests that derangement of mineral metabolism is involved in the onset of steroid osteopathy and myopathy.
Emel'ianov
A V
AV
Trofimov
V I
VI
D000293:Adolescent; D000328:Adult; D000368:Aged; D001249:Asthma / Q000188:drug therapy*; D002118:Calcium / Q000097:blood / Q000378:metabolism; D005260:Female; D005938:Glucocorticoids / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D007275:Injections, Intravenous; D008274:Magnesium / Q000097:blood / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D008903:Minerals / Q000097:blood / Q000378:metabolism*; D012138:Respiratory Therapy; D013054:Spectrophotometry, Atomic; D013997:Time Factors
D005938:Glucocorticoids; D008903:Minerals; D008274:Magnesium; D002118:Calcium