title: Resistance to the polyether ionophore antibiotic pandavir (nigericin) in two producing strains of Streptomyces.
abstract: In two pandavir (nigericin) producing strains, Streptomyces hygroscopicus 155 and Streptomyces albogriseolus 444, an enzyme activity was detected leading to inactivation of the antibiotic in the presence of ATP-Na2. Apparently, the observed inactivation is specific for the antibiotic produced by these strains. The nigericin producing strains were also found to be less permeable to pandavir than their non-producing variants.
authors.affiliation: Department of Microbiology, Sofia University, Bulgaria.
authors.forename: P A
authors.initials: PA
authors.lastname: Moncheva
authors.forename: K R
authors.initials: KR
authors.lastname: Christova
authors.forename: I V
authors.initials: IV
authors.lastname: Ivanova
mesh_terms: D000900:Anti-Bacterial Agents / Q000378:metabolism*; D002473:Cell Wall / Q000187:drug effects; D004352:Drug Resistance, Microbial / Q000502:physiology; D007476:Ionophores / Q000378:metabolism; D008985:Monensin / Q000378:metabolism; D009550:Nigericin / Q000378:metabolism*; D013302:Streptomyces / Q000378:metabolism*
chemical_list: D000900:Anti-Bacterial Agents; D007476:Ionophores; D008985:Monensin; D009550:Nigericin