title: Atrial ectopic activity and atrial fibrillation/flutter after coronary artery bypass surgery. A case-base study controlling for confounding from age, beta-blocker treatment, and time distance from operation.
abstract: To evaluate the impact of ectopic atrial activity and cardiac autonomic function for development of atrial fibrillation or flutter we studied 128 consecutive patients undergoing elective coronary artery bypass grafting. The patients were Holter monitored during a 96-h postoperative period. Autonomic balance was estimated by heart rate variability measurement. Thirty-eight (30%) patients developed sustained atrial fibrillation or flutter. Holter recordings were analyzed in a case-base design matching for age, beta-blocker treatment, and time elapsed after the operation. The number of supraventricular ectopic beats/h was increased (P < 0.01) in the case group during each of the last 7 h before onset of atrial fibrillation or flutter. Episodes of supraventricular tachycardia 62% vs. 26%; cases vs. controls (P = 0.007), episodes of non-sustained atrial fibrillation 29% vs. 0% (P = 0.0009), and episodes of non-sustained atrial flutter 15% vs. 0% (P = 0.05) were significant predictors of atrial fibrillation or flutter. Mean heart rate/h was increased in each of the 24 h preceding the arrhythmia. However, indexes of autonomic heart function did not differ significantly between groups. Patients developing atrial fibrillation or flutter after coronary artery bypass surgery present 'warning' atrial arrhythmias: numerous supraventricular ectopic beats, paroxysmal supraventricular tachycardia, and episodes of nonsustained atrial fibrillation and flutter.
authors.affiliation: Department of Cardiology, Skejby Sygehus, University Hospital, Aarhus, Denmark.
authors.forename: L
authors.initials: L
authors.lastname: Frost
authors.forename: H
authors.initials: H
authors.lastname: Mølgaard
authors.forename: E H
authors.initials: EH
authors.lastname: Christiansen
authors.forename: C J
authors.initials: CJ
authors.lastname: Jacobsen
authors.forename: H
authors.initials: H
authors.lastname: Pilegaard
authors.forename: P E
authors.initials: PE
authors.lastname: Thomsen
mesh_terms: D000319:Adrenergic beta-Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D000328:Adult; D000367:Age Factors; D000368:Aged; D001281:Atrial Fibrillation / Q000175:diagnosis / Q000503:physiopathology*; D001282:Atrial Flutter / Q000175:diagnosis / Q000503:physiopathology*; D001341:Autonomic Nervous System / Q000187:drug effects / Q000503:physiopathology; D016022:Case-Control Studies; D001026:Coronary Artery Bypass; D003327:Coronary Disease / Q000601:surgery*; D015716:Electrocardiography, Ambulatory / Q000187:drug effects; D005260:Female; D005500:Follow-Up Studies; D006325:Heart Atria / Q000187:drug effects / Q000503:physiopathology; D006339:Heart Rate / Q000187:drug effects / Q000502:physiology; D006801:Humans; D008297:Male; D008790:Metoprolol / Q000008:administration & dosage* / Q000009:adverse effects; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis / Q000503:physiopathology*; D012307:Risk Factors; D013612:Tachycardia, Ectopic Atrial / Q000175:diagnosis / Q000503:physiopathology*; D013614:Tachycardia, Paroxysmal / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D000319:Adrenergic beta-Antagonists; D008790:Metoprolol