title: Pyridazines, LXXII: On the synthesis of azinium and diazinium compounds structurally related to pyridazomycin.
abstract: Preparation of series of pyridine-, pyridazine-, and pyrazine-derived carboxamides bearing at the ring N-atom an alkyl side-chain with a terminal carboxylic group (7-11) or with a terminal acetylamino malonic ester moiety (13-17, 19-23) is described. Two desaza-pyridazomycin derivatives (24, 26) and homologs thereof (25, 27) were synthesised. The novel compounds which are structurally related to the antifungal antibiotic pyridazomycin were screened for antifungal activity: preliminary in vitro tests showed no activity.
authors.affiliation: Institute of Pharmaceutical Chemistry, University of Innsbruck, Austria.
authors.forename: J
authors.initials: J
authors.lastname: Easmon
authors.forename: G
authors.initials: G
authors.lastname: Heinisch
authors.forename: W
authors.initials: W
authors.lastname: Holzer
authors.forename: B
authors.initials: B
authors.lastname: Matuszczak
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D011719:Pyrazines / Q000138:chemical synthesis* / Q000494:pharmacology; D011724:Pyridazines / Q000737:chemistry / Q000494:pharmacology; D011725:Pyridines / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000935:Antifungal Agents; D011719:Pyrazines; D011724:Pyridazines; D011725:Pyridines; C056340:pyridazomycin