Uprolides D-G, 2. A rare family of 4,7-oxa-bridged cembranolides from the Caribbean gorgonian Eunicea mammosa.
Five new cytotoxic cembranolides possessing a rare 4,7-oxa-bridged functionality were isolated from the gorgonian Eunicea mammosa. The structures of 5, 7-9, and 10 were deduced from spectroscopic data and by chemical correlation experiments.
Rodríguez
A D
AD
Department of Chemistry, University of Pureto Rico, Río Piedras.
Soto
J J
JJ
Piña
I C
IC
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D003063:Cnidaria / Q000737:chemistry*; D004224:Diterpenes / Q000737:chemistry* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D011647:Puerto Rico; D013055:Spectrophotometry, Infrared; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D004224:Diterpenes