title: In vitro antimalarial activity of monoterpenic fragment analogues of aplasmomycin.
abstract: Synthetic analogues of a monoterpenic fragment of aplasmomycin were tested for their antimalarial activity in Plasmodium falciparum culture in vitro. The antimalarial activities of these agents were evaluated in chloroquine sensitive strains. Parasite growth was inhibited in a dose dependent manner in the presence of the synthetic compounds (3-9).
authors.affiliation: Malaria Research Centre, Delhi, India.
authors.forename: S
authors.initials: S
authors.lastname: Biswas
authors.forename: N
authors.initials: N
authors.lastname: Valecha
authors.forename: M L
authors.initials: ML
authors.lastname: Kundu
authors.forename: N
authors.initials: N
authors.lastname: Balu
authors.forename: J V
authors.initials: JV
authors.lastname: Thomas
authors.forename: S V
authors.initials: SV
authors.lastname: Bhat
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology*; D000962:Antimalarials / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D010455:Peptides; D010963:Plasmodium falciparum / Q000187:drug effects*; D013055:Spectrophotometry, Infrared; D013729:Terpenes / Q000737:chemistry / Q000494:pharmacology*
chemical_list: D000900:Anti-Bacterial Agents; D000962:Antimalarials; D010455:Peptides; D013729:Terpenes; C013401:aplasmomycin