Pathway of butyrate catabolism by Desulfobacterium cetonicum.
Desulfobacterium cetonicum 480 oxidized butyrate to 1 mol of acetate and 2 mol of CO2; this reaction was coupled to reduction of sulfate to sulfide. Butyrate was activated by coenzyme A (CoA) transfer from acetyl-CoA, and butyryl-CoA was oxidized to acetyl-CoA by a classical beta-oxidation pathway. Acetyl-CoA was oxidized through the acetyl-CoA/carbon monoxide dehydrogenase pathway. There was a rapid exchange of 14CO2 into the intermediate CoA esters and into acetate and butyrate, showing that all of the steps involved in the oxidation of butyrate to acetyl-CoA are reversible.
Janssen
P H
PH
Fakultät für Biologie, Universität Konstanz, Germany.
Schink
B
B
D000214:Acyl Coenzyme A / Q000378:metabolism; D002087:Butyrates / Q000378:metabolism*; D002245:Carbon Dioxide / Q000378:metabolism; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D008954:Models, Biological; D013431:Sulfates / Q000378:metabolism; D013440:Sulfides / Q000378:metabolism; D016999:Sulfur-Reducing Bacteria / Q000378:metabolism*
D000214:Acyl Coenzyme A; D002087:Butyrates; D005230:Fatty Acids, Nonesterified; D013431:Sulfates; D013440:Sulfides; D002245:Carbon Dioxide