[The effects of dopaminergic agents on the self-stimulation of the lateral hypothalamus and on dopamine metabolism in the brain of isolated rats with a disrupted ventral tegmental area].
Male Wistar rats were socially isolated from the 17th day of birth. Ventral tegmental area (VTA) of a half of the 17th-day rats was unilaterally damaged with intrastructural administration of kainic acid. In adult rats (both raised in groups and in isolation) amphetamine (1 mg/kg) facilitated self-stimulation of the lateral hypothalamus (by 37%). Social isolation increased the sensitivity of dopaminergic system only in rats with VTA lesions which was manifested in promoting self-stimulation after administration of amphetamine, though the level and turnover of tegmental dopamine was decreased. 6-Hydroxydopamine (75 mcg intracisternally), a catecholaminergic neurotoxin, significantly inhibited self-stimulation in isolated rats and decreased catecholamine levels in the lateral hypothalamus. The neurotoxic effect of 6-hydroxydopamine was abolished by amphetamine, probably, owing to enhancement of the functional activity of parabiotically living neuronal structures of the mesocorticolimbic dopaminergic system of the brain.
Lebedev
A A
AA
Loseva
I V
IV
Shabanov
P D
PD
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000378:metabolism; D001923:Brain Chemistry / Q000187:drug effects; D004298:Dopamine / Q000032:analysis / Q000378:metabolism*; D015259:Dopamine Agents / Q000494:pharmacology*; D004558:Electric Stimulation; D004567:Electrodes, Implanted; D007026:Hypothalamic Area, Lateral / Q000737:chemistry / Q000187:drug effects* / Q000502:physiology; D007608:Kainic Acid; D008297:Male; D016627:Oxidopamine / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D012653:Self Stimulation / Q000187:drug effects* / Q000502:physiology; D012934:Social Isolation; D017557:Ventral Tegmental Area / Q000187:drug effects / Q000502:physiology*
D015259:Dopamine Agents; D016627:Oxidopamine; D000661:Amphetamine; D007608:Kainic Acid; D004298:Dopamine