title: Responses of substantia nigra pars reticulata and globus pallidus complex to high frequency stimulation of the subthalamic nucleus in rats: electrophysiological data.
abstract: High frequency stimulation of the subthalamic nucleus (STN-HFS) has been shown to reverse parkinsonian motor symptoms in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-treated monkeys. We have studied the effect of STN-HFS on the spontaneous activity of the substantia nigra pars reticulata (SNr), entopeduncular nucleus (EP) and globus pallidus (GP) in rats. STN-HFS induced a decrease in activity of 91% of SNr cells, a suppression of activity in 80% of EP cells and an activation of 100% of GP recorded cells. These results show that STN-HFS exerts an inhibitory influence on the basal ganglia output structures similar to that obtained by STN lesion.
authors.affiliation: Laboratoire de Neurobiophysique, UJFG, INSERM U.318, Centre Hospitalier Universitaire de Grenoble, France.
authors.forename: A
authors.initials: A
authors.lastname: Benazzouz
authors.forename: B
authors.initials: B
authors.lastname: Piallat
authors.forename: P
authors.initials: P
authors.lastname: Pollak
authors.forename: A L
authors.initials: AL
authors.lastname: Benabid
mesh_terms: D000818:Animals; D001479:Basal Ganglia / Q000502:physiology; D004558:Electric Stimulation; D004594:Electrophysiology; D005917:Globus Pallidus / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D013378:Substantia Nigra / Q000502:physiology*; D013787:Thalamic Nuclei / Q000502:physiology*