title: Radiosurgery in the initial management of malignant gliomas: survival comparison with the RTOG recursive partitioning analysis. Radiation Therapy Oncology Group.
abstract: OBJECTIVE
  To evaluate the impact of stereotactic radiosurgery on the survival of patients treated with malignant gliomas.
  
  
  METHODS
  A total of 115 patients from three institutions (75 from the Joint Center for Radiation Therapy, 30 from the University of Wisconsin, and 10 from the University of Florida) were treated with a combination of surgery, external beam radiation therapy, and linac-based radiosurgery as part of similar institutional protocols from March 1988 through July 1993. Patients were stratified into six prognostic classes (classes 1-6) based on the recursive partitioning analysis of multiple prognostic factors previously reported by the Radiation Therapy Oncology Group.
  
  
  RESULTS
  The actuarial 2-year and median survival for all patients analyzed was 45% and 96 weeks, respectively. In comparison to the results from a previously published analysis of 1578 patients entered on three Radiation Therapy Oncology Group external beam radiotherapy protocols from 1974 to 1989, those patients treated with radiosurgery had a significantly improved 2-year and median survival (p = 0.01) corresponding with a standardized mortality risk ratio of 0.51 [95% confidence interval (CI): 0.31, 0.85]. This improvement in survival was seen predominantly for the worse prognostic classes (classes 3-6). The 2-year survival for the radiosurgical patients compared with the previously reported patients was 81% vs. 76% for classes 1/2, 75% vs. 35% for class 3, 34% vs. 15% for class 4, and 21% vs. 6% for classes 5/6, respectively. Although Karnofsky performance status and prognostic class were significant on univariate analysis, only the Karnofsky score was a significant predictor of outcome on multivariate analysis. Median and 2-year survival for patients with a Karnofsky score > or = 70 was 106 weeks and 51%, respectively, as compared to 38 weeks and 0% for patients with a Karnofsky score < 70% (p = 0.001).
  
  
  CONCLUSIONS
  The addition of radiosurgery to conventional treatment (surgery and external beam radiotherapy) of malignant gliomas appears to improve survival when compared to historical reports. These results should be interpreted with caution because the recursive partitioning model does not completely predict the prognosis of the patients treated in the present study. Although this study suggests that radiosurgery may prolong survival in patients with malignant gliomas, the role of radiosurgery in the management of these patients remains to be defined by a prospective randomized trial.
authors.affiliation: Department of Human Oncology, University of Wisconsin School of Medicine, Madison 53792, USA.
authors.forename: J N
authors.initials: JN
authors.lastname: Sarkaria
authors.forename: M P
authors.initials: MP
authors.lastname: Mehta
authors.forename: J S
authors.initials: JS
authors.lastname: Loeffler
authors.forename: J M
authors.initials: JM
authors.lastname: Buatti
authors.forename: R J
authors.initials: RJ
authors.lastname: Chappell
authors.forename: A B
authors.initials: AB
authors.lastname: Levin
authors.forename: E
authors.initials: E
authors.lastname: Alexander
authors.forename: W A
authors.initials: WA
authors.lastname: Friedman
authors.forename: T J
authors.initials: TJ
authors.lastname: Kinsella
mesh_terms: D001932:Brain Neoplasms / Q000401:mortality / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D005909:Glioblastoma / Q000401:mortality / Q000601:surgery*; D006801:Humans; D008297:Male; D016634:Radiosurgery / Q000379:methods*; D016019:Survival Analysis; D017211:Treatment Failure