Secretoneurin in bronchopulmonary carcinoids--immunohistochemical comparison with chromogranins A and B and secretogranin II.
Ninety-nine classical and 11 atypical bronchopulmonary carcinoids were investigated immunohistochemically with an antibody against secretoneurin, a peptide proteolytically processed from secretogranin II (chromogranin C), as well as antibodies against chromogranin A and B and secretogranin II. Secretoneurin was immunolocalized in 86 tumours (78 classical and eight atypical carcinoids); secretogranin II was found in the same tumours in a similar distribution, whereas chromogranin A was present in all 100 and chromogranin B in 106 tumours investigated. Bronchopulmonary carcinoids are usually not associated with clinically or biochemically distinct syndromes. Although we found bronchial carcinoids with different immunohistochemical chromogranins/secretogranin patterns, no correlation with the biological behaviour of these tumours could be demonstrated.
Tötsch
M
M
Department of Pathology, University of Münster, Germany.
Padberg
B C
BC
Schröder
S
S
Ofner
D
D
Böcker
W
W
Fischer-Colbrie
R
R
Schmid
K W
KW
D002276:Carcinoid Tumor / Q000737:chemistry*; D053379:Chromogranin A; D002864:Chromogranins / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D008175:Lung Neoplasms / Q000737:chemistry*; D009479:Neuropeptides / Q000032:analysis*; D011506:Proteins / Q000032:analysis*; D053381:Secretogranin II
D053379:Chromogranin A; D002864:Chromogranins; D009479:Neuropeptides; D011506:Proteins; D053381:Secretogranin II; C081159:secretoneurin