Staphylococcal enterotoxin B affects in vitro IgE synthesis, interferon-gamma, interleukin-4 and interleukin-5 production in atopic eczema.
Peripheral blood mononuclear cells from patients with atopic eczema (AE) stimulated with the 'superantigen' Staphylococcus enterotoxin B (SEB) secreted significantly more interleukin (IL)-4 and IL-5 as well as IgE, and markedly less interferon-gamma than those from healthy controls. Our results support the assumption that SEB produced by S. aureus colonizing the skin of patients with AE may induce expansion of IL-4- and IL-5-producing Th2 clones, leading to increased IgE synthesis and eosinophil activation.
Neuber
K
K
Department of Dermatology and Allergology, University Hospital Hamburg, Germany.
Steinrücke
K
K
Ring
J
J
D000942:Antigens, Bacterial / Q000276:immunology*; D002478:Cells, Cultured; D017077:Culture Media, Conditioned / Q000737:chemistry; D003876:Dermatitis, Atopic / Q000097:blood / Q000276:immunology*; D004485:Eczema / Q000276:immunology* / Q000473:pathology; D004768:Enterotoxins / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000096:biosynthesis*; D007371:Interferon-gamma / Q000096:biosynthesis* / Q000378:metabolism; D015847:Interleukin-4 / Q000096:biosynthesis* / Q000378:metabolism; D015848:Interleukin-5 / Q000096:biosynthesis* / Q000378:metabolism; D008213:Lymphocyte Activation / Q000187:drug effects*; D013211:Staphylococcus aureus / Q000276:immunology*; D018089:Superantigens / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology* / Q000378:metabolism
D000942:Antigens, Bacterial; D017077:Culture Media, Conditioned; D004768:Enterotoxins; D015848:Interleukin-5; D018089:Superantigens; D015847:Interleukin-4; D007073:Immunoglobulin E; C031818:enterotoxin B, staphylococcal; D007371:Interferon-gamma