Laboratory markers of colonoscopic activity in ulcerative colitis and Crohn's colitis.
BACKGROUND
Previous studies have not identified a convenient laboratory marker of colonoscopic activity in Crohn's colitis or ulcerative colitis.


METHODS
Twenty-eight patients with either ulcerative colitis or Crohn's colitis undergoing colonoscopy by the same observed had laboratory measurements of serum albumin, orosomucoid, C-reactive protein, plasma viscosity, haemoglobin, leucocyte and platelet counts, and faecal alpha-1-antitrypsin from single non-lyophilized samples. Multiple linear regression was performed using each laboratory variable as the dependent variable and the lengths of each grade of endoscopic activity as the explanatory variables.


RESULTS
Multiple regression analysis using all the endoscopic grades of acute activity showed significant correlations with faecal alpha-1-antitrypsin (p < 0.001), serum albumin (p < 0.001), C-reactive protein (p = 0.02), and plasma viscosity (p = 0.03).


CONCLUSIONS
The highest multiple correlation coefficients were obtained with faecal alpha-1-antitrypsin (r = 0.82) and serum albumin (r = 0.80), and these measurements can be recommended as convenient markers of endoscopic activity in these diseases.
Moran
A
A
Dept. of Medicine, University of Bristol, England.
Jones
A
A
Asquith
P
P
D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000032:analysis / Q000097:blood; D001809:Blood Viscosity; D002097:C-Reactive Protein / Q000032:analysis; D003093:Colitis, Ulcerative / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism; D003113:Colonoscopy; D003424:Crohn Disease / Q000097:blood / Q000175:diagnosis* / Q000378:metabolism; D005243:Feces / Q000737:chemistry; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012044:Regression Analysis; D012709:Serum Albumin / Q000032:analysis; D000515:alpha 1-Antitrypsin / Q000032:analysis
D015415:Biomarkers; D012709:Serum Albumin; D000515:alpha 1-Antitrypsin; D002097:C-Reactive Protein