Role of hepatic nerves in long-term control of NaCl homeostasis in Wistar-Kyoto rats.
This study was designed to investigate the effects of hepatic denervation (HD) on NaCl balance and arterial blood pressure in conscious Wistar-Kyoto rats maintained on normal or high-NaCl food. When rats were fed normal NaCl food (0.45% NaCl), HD had no significant effect on NaCl balance and arterial pressure. However, when rats were fed high-NaCl food (8% NaCl for 10 days), NaCl balance became more positive in HD rats than in sham rats. Furthermore, mean arterial pressure in HD rats (120 +/- 2 mmHg) was higher than that in sham rats (108 +/- 3 mmHg). These results indicate that the hepatic nerves play a significant role in the long-term control of NaCl balance and arterial pressure during high-NaCl food intake.
Morita
H
H
Department of Physiology, Kagawa Medical School, Japan.
Chen
Q
Q
Hosomi
H
H
D000818:Animals; D001835:Body Weight; D002712:Chlorides / Q000378:metabolism / Q000652:urine*; D004435:Eating; D006706:Homeostasis; D008099:Liver / Q000294:innervation* / Q000378:metabolism; D008297:Male; D009412:Nerve Fibers / Q000502:physiology*; D051381:Rats; D011921:Rats, Inbred WKY; D012965:Sodium Chloride / Q000378:metabolism*; D017673:Sodium Chloride, Dietary
D002712:Chlorides; D017673:Sodium Chloride, Dietary; D012965:Sodium Chloride