title: A controlled trial of cisapride in anorexia nervosa.
abstract: To determine the efficacy of cisapride, 10 mg three times daily, in improving gastric emptying, reducing distress during meals, and facilitating weight gain in anorexia nervosa, we conducted an 8-week, randomized, double-blind, placebo-controlled trial on 29 inpatients. Measures included scintigraphic gastric emptying studies at 0, 2, 4, and 8 weeks; subjective distress during meals measured by visual analogue scales; self-rating of degree of global improvement in symptoms associated with eating at end of study; and weight measured weekly. Gastric emptying improved significantly but equally in both groups over the study period. Yet subjective measures were better in the cisapride group; they rated themselves as more hungry (p = .02) and more improved on the global measure of change in symptoms (p = .02). Even so, the cisapride group did not gain more weight. The correlation between gastric emptying and weight gain was modest (r = .30; p = .11), and between gastric emptying and the subjective measures, virtually absent.
authors.affiliation: Maudsley Hospital, London, UK.
authors.forename: G I
authors.initials: GI
authors.lastname: Szmukler
authors.forename: G P
authors.initials: GP
authors.lastname: Young
authors.forename: G
authors.initials: G
authors.lastname: Miller
authors.forename: M
authors.initials: M
authors.lastname: Lichtenstein
authors.forename: D S
authors.initials: DS
authors.lastname: Binns
mesh_terms: D000293:Adolescent; D000328:Adult; D000856:Anorexia Nervosa / Q000188:drug therapy*; D020117:Cisapride; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D005746:Gastric Emptying / Q000187:drug effects; D006801:Humans; D010147:Pain Measurement; D010880:Piperidines / Q000008:administration & dosage* / Q000009:adverse effects; D012702:Serotonin Antagonists / Q000008:administration & dosage* / Q000009:adverse effects; D016896:Treatment Outcome; D015430:Weight Gain / Q000187:drug effects
chemical_list: D010880:Piperidines; D012702:Serotonin Antagonists; D020117:Cisapride