title: Idiospermuline, a trimeric pyrrolidinoindoline alkaloid from the seed of Idiospermum australiense.
abstract: Purification of a methanol extract from the seed of Idiospermum australiense, guided by bioactivity on a rat brain cortical wedge preparation has afforded two known dimeric alkaloids, the piperidinoindoline (+)-calycanthine [1] and the pyrrolidinoindoline, (-)-chimonanthine [2] along with a new trimeric pyrrolidinoindoline alkaloid, (-)-idiospermuline [3]. Te structure of idiospermuline [3] was determined by spectroscopic methods and the absolute configuration by an X-ray crystallographic study of idiospermuline trimethiodide [4].
authors.affiliation: Department of Pharmacology, School of Chemistry, University of Sydney, New South Wales, Australia.
authors.forename: R K
authors.initials: RK
authors.lastname: Kuke
authors.forename: R D
authors.initials: RD
authors.lastname: Allan
authors.forename: G A
authors.initials: GA
authors.lastname: Johnston
authors.forename: K N
authors.initials: KN
authors.lastname: Mewett
authors.forename: A D
authors.initials: AD
authors.lastname: Mitrovic
authors.forename: C C
authors.initials: CC
authors.lastname: Duke
authors.forename: T W
authors.initials: TW
authors.lastname: Hambley
mesh_terms: D000109:Acetylcholine / Q000494:pharmacology; D000470:Alkaloids / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000818:Animals; D002540:Cerebral Cortex / Q000187:drug effects; D018678:Cholinergic Agents / Q000494:pharmacology; D018360:Crystallography, X-Ray; D066298:In Vitro Techniques; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D009467:Neuromuscular Depolarizing Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000032:analysis; D010947:Plants, Toxic / Q000737:chemistry*; D011760:Pyrrolidinones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012639:Seeds / Q000737:chemistry
chemical_list: D000470:Alkaloids; D018678:Cholinergic Agents; D009467:Neuromuscular Depolarizing Agents; D010936:Plant Extracts; D011760:Pyrrolidinones; C096507:idiospermuline; D000109:Acetylcholine