[Screening program with urinary porphyrins--application to clinical finding in latent porphyrias].
Judging from the incidence of porphyria in Japan, most cases can be diagnosed by measurement of the amount of porphyrin in the urine. Normally, the analysis of porphyrin in urine is performed by high-performance liquid chromatography but this requires about 40 minutes per specimen. However, if one simply measures coproporphyrin I and III only, then one specimen can be measured in about 10 minutes. If screening is performed using this method, those subjects in which high levels of coproporphyrin I and III are detected can undergo further test of urine, blood and feces to detect porphyrin and related materials. Using this screening methods in high school students, 2 cases of congenital porphyria were detected. One case was hereditary coproporphyria and the other was acute intermittent porphyria. If this method is added to screening methods normally used for health checkups, cases of porphyria should be detected with ease.
Kudo
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Y
Department of Hygiene, St. Marianna University School of Medicine.
D000293:Adolescent; D002851:Chromatography, High Pressure Liquid; D002986:Clinical Trials as Topic; D003306:Coproporphyrins / Q000652:urine*; D006801:Humans; D008403:Mass Screening / Q000379:methods*; D011164:Porphyrias / Q000517:prevention & control*
D003306:Coproporphyrins; C026971:coproporphyrin III; C031467:coproporphyrin I