title: Protease activity in the mouse dental follicle during tooth eruption.
abstract: Eruption results in the movement of the tooth from an intraosseous to a functional position in the mouth. This physiological movement occurs through a path of least resistance and is mediated by the dental follicle. In this study the presence of a 80-kDa proteinase of the gelatinase family in the dental follicle of mandibular first molars obtained from CD-1 mouse neonates was investigated by zymography on sodium dodecyl sulphate-gelatin. The results showed a differential distribution of this proteinase in the coronal and apical parts of the follicle at postnatal days 9 and 11. The findings suggest that the onset of this differential enzymatic activity is concomitant with the initiation of tooth eruption.
authors.affiliation: Department of Orthodontics, University of Maryland School of Dentistry, Baltimore, USA.
authors.forename: B
authors.initials: B
authors.lastname: Shroff
authors.forename: K
authors.initials: K
authors.lastname: Norris
authors.forename: R
authors.initials: R
authors.lastname: Pileggi
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D003795:Dental Sac / Q000201:enzymology*; D004591:Electrophoresis, Polyacrylamide Gel; D018093:Gelatinases / Q000032:analysis / Q000378:metabolism*; D006651:Histocytochemistry; D051379:Mice; D008815:Mice, Inbred Strains; D014078:Tooth Eruption / Q000502:physiology*
chemical_list: D018093:Gelatinases