Hemopoietic growth and inhibitory factors in treatment of malignancies. A review.
The clinical use of cytokines is still expanding as the knowledge of beneficial effects as adjunct to cancer treatment is increasing. G-CSF and GM-CSF stimulates hemopoietic recovery after myelosuppressive chemotherapy and enhances engraftment after bone marrow transplantation. New cytokines as IL-1, IL-3, IL-4 and IL-6, are studied in clinical trials and combinations of these with stem cell factor seem promising in ex vivo expansion of stem cells. GM-CSF also have antitumor effects. The most recently discovered hemopoietic growth factor is thrombopoietin, from which probably especially patients with leukemia will benefit.
Hansen
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Department of Oncology, Aarhus University Hospital, Denmark.
D000818:Animals; D017024:Chemotherapy, Adjuvant; D016298:Hematopoietic Cell Growth Factors / Q000627:therapeutic use*; D006801:Humans; D007378:Interleukins / Q000627:therapeutic use*; D009369:Neoplasms / Q000628:therapy*; D009374:Neoplasms, Experimental / Q000628:therapy; D013926:Thrombopoietin / Q000627:therapeutic use*
D016298:Hematopoietic Cell Growth Factors; D007378:Interleukins; D013926:Thrombopoietin