title: Metabolic rate in severe head trauma.
abstract: BACKGROUND
  The metabolic rate of patients suffering severe head trauma (HT) is not well defined, and large variations of resting energy expenditure (REE) have been reported, suggesting an important nonuniformity of REE distribution in HT patients. The purpose of this clinical study was to assess the metabolic rate in mechanically ventilated patients suffering from severe isolated HT, or HT associated with other injuries, in the absence of gross motor activity.
  
  
  METHODS
  Eighty HT patients undergoing mechanical ventilation were studied between 48 and 72 hours after injury. Three groups of patients were studied in the following clinical settings: (group A) isolated HT, not receiving morphine (n = 34); (group B) isolated HT, receiving an intravenous perfusion of morphine (n = 26) to control gross motor activity; and (group C) HT associated with other serious injuries, receiving intravenous morphine (n = 20) to induce sedation and analgesia. REE was measured with the open-Douglas-bag method.
  
  
  RESULTS
  No significant differences among the three groups were found in the metabolic rate expressed as the percentage of measured REE from predicted REE and REE expressed in terms of body weight. The mean percent measured REE was 123 +/- 16, and REE expressed in terms of body weight was 30 +/- 5 kcal/kg per day. Severe hypermetabolism was diagnosed if mean percent measured REE was greater than 130 and was present in 25 of 80 (31%) patients.
  
  
  CONCLUSIONS
  Severe HT treated with or without morphine was characterized by a moderate state of hypermetabolism after the first days of trauma, but an important proportion of HT patients showed considerably elevated metabolic rates.
authors.affiliation: Intensive Care Unit, Hospital Son Dureta Hospital, Palma de Mallorca, Spain.
authors.forename: J M
authors.initials: JM
authors.lastname: Raurich
authors.forename: J
authors.initials: J
authors.lastname: Ibáñez
mesh_terms: D000328:Adult; D001481:Basal Metabolism; D001930:Brain Injuries / Q000188:drug therapy / Q000378:metabolism*; D004734:Energy Metabolism; D005260:Female; D015600:Glasgow Coma Scale; D006801:Humans; D007700:Kinetics; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000627:therapeutic use; D011446:Prospective Studies
chemical_list: D009020:Morphine