title: Dobutamine-induced ST-segment elevation in patients with healed myocardial infarction. A marker of myocardial viability.
abstract: The purpose of this study was to determine the significance of transient ST-segment elevation during dobutamine infusions in patients with healed Q wave myocardial infarction. Twenty-seven patients with previous Q wave myocardial infarction were studied prospectively with dobutamine-thallium-201 single-photon emission computed tomography. The presence of ST-segment elevation in leads with Q waves was related to thallium reversibility at 4-hour redistribution imaging or after reinjection, to residual flow, as well as to wall motion abnormalities in the infarcted zone. ST-segment elevation in infarct-related leads was observed in 15 patients; 11 (73%) showed viability by thallium-201 in the infarcted zone. In patients without ST-segment elevation, viability was shown less frequently (33%, P < .05). Hypokinesis in infarcted segments was present in 60% of patients with ST-segment elevation and in 25% of patients without ST-segment elevation (.05 < P < .1). Finally, infarct-related artery was patent and/or collaterals were present in 10 patients with ST-segment elevation (67%) and in 4 patients without (33%, .05 < P < .1). In conclusion, ST-segment elevation during dobutamine infusion is a marker of residual viability in infarcted segments.
authors.affiliation: Department of Clinical Therapeutics, Alexandra University Hospital, Athens, Greece.
authors.forename: J P
authors.initials: JP
authors.lastname: Lekakis
authors.forename: V
authors.initials: V
authors.lastname: Prassopoulos
authors.forename: P
authors.initials: P
authors.lastname: Kostamis
authors.forename: S
authors.initials: S
authors.lastname: Moulopoulos
mesh_terms: D000328:Adult; D000368:Aged; D004280:Dobutamine; D004562:Electrocardiography; D005080:Exercise Test; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000000981:diagnostic imaging / Q000503:physiopathology*; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D013794:Thallium Radioisotopes; D004280:Dobutamine