title: A minipig model for urodynamic evaluation of infravesical obstruction and its possible reversibility.
abstract: OBJECTIVE
  The aim of our study was to create reproducible partial bladder outlet obstruction and to evaluate the resulting urodynamic changes.
  
  
  METHODS
  Thirty-one female Yucatan microswine were randomly divided into obstructed and control groups. In the obstructed group of 21 animals, an artificial 4.5-cm. sphincter cuff was placed around the bladder neck. Fourteen of these minipigs were eventually deobstructed. In the controls (unobstructed sham-operated group), the sphincter cuff was removed prior to closure. Urodynamic measurements were conducted at 2, 4, 8 and 12 weeks postobstruction in conscious animals restrained in specially designed adjustable cages.
  
  
  RESULTS
  (with all pressures in cm.H2O): 1) Unobstructed sham controls: Pdet,open 28.8 Pdet (Qmax) 22.5, Qmax 30.8 ml. per second, Pdet,isv 61.7, urethral resistance relation (URA) 7.7 cm.H2O, and Watts factor (WF) 4.7 W/m.2; 2) Obstructed group: Pdet,open 85.2; Pdet (Qmax) 94.4, Qmax 5.6 ml. per second, Pdet,isv 135.2, mean URA 74.3 cm.H2O and WF 13.5 W/m.2; 3) Deobstructed group: Pdet,open 39.9, Pdet (Qmax) 25.9, Qmax 25.0 ml. per second, Pdet,isv 58.0, mean URA 8.9 cm.H2O and WF 5.4 W/m.2.
  
  
  CONCLUSIONS
  This animal model of reversible infravesical obstruction has given consistent and reproducible pressure flow data in the conscious, upright state.
authors.affiliation: Department of Urology, Norman Bethune University of Medical Science, Chang Chun, China.
authors.forename: Z
authors.initials: Z
authors.lastname: Guan
authors.forename: G
authors.initials: G
authors.lastname: Kiruluta
authors.forename: B
authors.initials: B
authors.lastname: Coolsaet
authors.forename: M
authors.initials: M
authors.lastname: Elhilali
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D005260:Female; D009119:Muscle Contraction; D009130:Muscle, Smooth / Q000503:physiopathology; D011312:Pressure; D011897:Random Allocation; D013552:Swine; D013556:Swine, Miniature; D014521:Urethra / Q000503:physiopathology; D001748:Urinary Bladder Neck Obstruction / Q000503:physiopathology*; D014563:Urodynamics