[Analysis of various mechanisms of action of lactin on plasma volume restoration in hemorrhagic shock].
Experiments on 52 unconscious male cats have established that intravenous administration of lactin in a dose of 50 U/kg 1.5 hrs after 30% blood loss causes intracellular fluid to move into the extracellular space, which is accompanied by restoration of the plasma volume up to 94% of the baseline value and by enhancement of diuresis without substantial changes in the tissue hydrostatic pressure and osmolar concentration of plasma. The simultaneous use of lactin and verospiron, (3 mg/kg, i.p.), unlike lactin alone, retained the restored plasma volume in survived animals in the first 24 hours of blood loss.
Dzhurko
B I
BI
D000818:Animals; D002415:Cats; D007785:Lactose / Q000494:pharmacology*; D008297:Male; D010953:Plasma Volume / Q000187:drug effects*; D012771:Shock, Hemorrhagic / Q000097:blood / Q000188:drug therapy*
D007785:Lactose