title: Immunoreactive inhibin concentrations in human gonads and adrenals during the first years of life.
abstract: We determined immunoreactive inhibin (irINH) concentration in the gonads and adrenals of healthy children (0-75 months) who had died suddenly. Testicular irINH peaked in the first 3 months of life with a significant drop in the 4th month (p < 0.05). In ovarian tissue, irINH was significantly lower than in the testes (p < 0.001) with highest levels during the first 4 months of life parallel to the highest estradiol concentrations. A significant correlation between gonadal testosterone/estradiol and irINH was observed. In adrenal tissue, irINH levels were significantly lower than in the gonads without sex-specific differences.
authors.affiliation: Department of Clinical Biochemistry, University of Bonn, Germany.
authors.forename: W
authors.initials: W
authors.lastname: Brennemann
authors.forename: D
authors.initials: D
authors.lastname: Klingmüller
authors.forename: N
authors.initials: N
authors.lastname: Eter
authors.forename: F
authors.initials: F
authors.lastname: Bidlingmaier
mesh_terms: D000311:Adrenal Glands / Q000254:growth & development* / Q000378:metabolism*; D000735:Androstenedione / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D004958:Estradiol / Q000378:metabolism; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007265:Inhibins / Q000378:metabolism*; D008297:Male; D010053:Ovary / Q000254:growth & development* / Q000378:metabolism*; D012727:Sex Characteristics; D013737:Testis / Q000254:growth & development* / Q000378:metabolism*; D013739:Testosterone / Q000378:metabolism
chemical_list: D013739:Testosterone; D000735:Androstenedione; D004958:Estradiol; D007265:Inhibins