title: T-brain-1: a homolog of Brachyury whose expression defines molecularly distinct domains within the cerebral cortex.
abstract: The mechanisms that regulate regional specification and evolution of the cerebral cortex are obscure. To this end, we have identified and characterized a novel murine and human gene encoding a putative transcription factor related to the Brachyury (T) gene that is expressed only in postmitotic cells. T-brain-1 (Tbr-1) mRNA is largely restricted to the cerebral cortex, where during embryogenesis it distinguishes domains that we propose may give rise to paleocortex, limbic cortex, and neocortex. Tbr-1 and Id-2 expression in the neocortex have discontinuities that define molecularly distinct neocortical areas. Tbr-1 expression is analyzed in the context of the prosomeric model. Topological maps are proposed for the organization of the dorsal telencephalon.
authors.affiliation: Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, University of California, San Francisco 94143, USA.
authors.forename: A
authors.initials: A
authors.lastname: Bulfone
authors.forename: S M
authors.initials: SM
authors.lastname: Smiga
authors.forename: K
authors.initials: K
authors.lastname: Shimamura
authors.forename: A
authors.initials: A
authors.lastname: Peterson
authors.forename: L
authors.initials: L
authors.lastname: Puelles
authors.forename: J L
authors.initials: JL
authors.lastname: Rubenstein
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002540:Cerebral Cortex / Q000502:physiology*; D002874:Chromosome Mapping; D003001:Cloning, Molecular; D004247:DNA / Q000235:genetics*; D004268:DNA-Binding Proteins / Q000235:genetics*; D005326:Fetal Proteins / Q000235:genetics*; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D006801:Humans; D017403:In Situ Hybridization; D051379:Mice; D008969:Molecular Sequence Data; D016548:Prosencephalon / Q000502:physiology; D017422:Sequence Analysis, DNA; D012689:Sequence Homology, Nucleic Acid; D020825:T-Box Domain Proteins; D016385:TATA Box / Q000235:genetics; D013788:Thalamus / Q000502:physiology; D014157:Transcription Factors / Q000235:genetics; D000098908:Brachyury Protein
chemical_list: D004247:DNA; D004268:DNA-Binding Proteins; D005326:Fetal Proteins; D020825:T-Box Domain Proteins; D014157:Transcription Factors; D000098908:Brachyury Protein