title: [Evaluation of hilar 67Ga-citrate uptake in bronchogenic carcinoma].
abstract: We evaluated hilar uptake on 67Ga-citrate scintigraphy and correlated with hilar lymph node metastases in one-hundred seventeen cases (two-hundred thirty four hila) of bronchogenic carcinoma. Hilar uptake was classified into three grades independently on anterior and posterior chest views: no uptake (grade 0), uptake equal to that in the thoracic vertebrae (grade 1), uptake higher than that in the thoracic vertebrae (grade 2). If a summed grade of anterior and posterior view was larger than 3, hilar uptake was considered as positive. In forty-four cases (forty-nine hila) with hilar lymph node metastases, positive hilar uptake was found in ten cases (eleven hila), resulting in sensitivity of 22% based on cases and 23% based on hila. In seventy-three cases (one-hundred forty-six hila) without hilar lymph node metastases, positive hilar uptake was found in six cases (ten hila), resulting in specificity of 91% based on cases and 93% based on hila. In comparison to scintigraphic findings of unilaterally positive hilar uptake, findings of bilaterally positive hilar uptake showed significantly lower accuracy in determining presence of hilar lymph node metastases. No definite correlation between hilar uptake and histopathology or 67Ga-citrate uptake in a primary tumor was observed. The results indicate that usefulness of 67Ga-citrate scintigraphy is limited when evaluating hilar lymph node metastases in bronchogenic carcinoma.
authors.affiliation: Department of Radiology, Chiba University School of Medicine.
authors.forename: N
authors.initials: N
authors.lastname: Matsuno
authors.forename: J
authors.initials: J
authors.lastname: Kuyama
authors.forename: Y
authors.initials: Y
authors.lastname: Uchida
authors.forename: S
authors.initials: S
authors.lastname: Minoshima
authors.forename: O
authors.initials: O
authors.lastname: Hatano
authors.forename: Y
authors.initials: Y
authors.lastname: Imai
authors.forename: K
authors.initials: K
authors.lastname: Uno
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002283:Carcinoma, Bronchogenic / Q000000981:diagnostic imaging* / Q000473:pathology; D002951:Citrates / Q000493:pharmacokinetics; D019343:Citric Acid; D005260:Female; D005710:Gallium Radioisotopes / Q000493:pharmacokinetics; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging* / Q000378:metabolism; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging
chemical_list: D002951:Citrates; D005710:Gallium Radioisotopes; D019343:Citric Acid