[The comparative evaluation of the efficacy of tocopherol acetate in the combined treatment of patients with hypertension and diabetes mellitus].
Time course was studied of indices for lipid peroxidation (LPO) and total lipids count in erythrocytic membranes (EM) and blood plasma (BP) of patients with essential hypertension (EH) associated with diabetes mellitus (DM), under the effect of alpha-tocopherol. EH patients demonstrated intensification of LPO in cellular membranes and BP. Association of EH with DM is responsible for a more significant increase of the levels of accumulation of LPO products in EM and rise in total lipids content both in cellular membranes and BP. The use of alpha-tocopheroli acetas in combination therapy of both EH- and EH+ DM patients promoted normalization of LPO processes in EM and reduction of BP content of the LPO products.
Kuznetsov
N S
NS
Abulela
A M
AM
Neskromnyĭ
V N
VN
D000328:Adult; D000959:Antihypertensive Agents / Q000627:therapeutic use; D000975:Antioxidants / Q000627:therapeutic use*; D003920:Diabetes Mellitus / Q000097:blood / Q000188:drug therapy*; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D006973:Hypertension / Q000097:blood / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000627:therapeutic use; D015227:Lipid Peroxidation / Q000187:drug effects; D008054:Lipid Peroxides / Q000097:blood; D008563:Membrane Lipids / Q000097:blood; D008875:Middle Aged; D024505:Tocopherols; D014810:Vitamin E / Q000031:analogs & derivatives* / Q000627:therapeutic use; D024502:alpha-Tocopherol / Q000031:analogs & derivatives*
D000959:Antihypertensive Agents; D000975:Antioxidants; D007004:Hypoglycemic Agents; D008054:Lipid Peroxides; D008563:Membrane Lipids; D014810:Vitamin E; D024502:alpha-Tocopherol; D024505:Tocopherols