title: Effects of intravenous injection and intraperitoneal continual administration of sodium propionate on serum cholesterol levels in rats.
abstract: To examine the effects of sodium propionate on serum cholesterol levels, rats were given sodium propionate intravenously and intraperitonealy. Six-week-old male Sprague-Dawley rats were kept on a cholesterol-free semisynthetic diet for 2 weeks, fasted, and given 400 microliters of saline solution intravenously supplemented with 0.01-10 mg sodium propionate. Three hours after injection of 1 mg of sodium propionate, the serum total-cholesterol level was significantly reduced (85.4 +/- 4.0 mg/dl) compared with its starting level (102 +/- 3.4 mg/dl), with the reducing effect lasting for 24 h. The intensity of the reduction increased proportionately with increased sodium propionate concentrations from 0.01 to 1 mg. Next, to evaluate the influence of continual sodium propionate administration on serum cholesterol levels, 6-week-old male rats were implanted with an osmotic pump intraperitonealy (ALZET Model 2ML2, pumping rate: 5.0 microliter/h; duration: 14 days; reservoir volume: 2,000 microliters). At day 14, serum total-cholesterol levels were reduced by continual sodium propionate administration at both 0.12 and 1.2 mg/day. The maximum percentage change in the serum total-cholesterol level was 78.5 +/- 6.7% of its starting level (111 +/- 7.1 mg/dl), observed at 1.2 mg/day at day 7. These results indicate that sodium propionate can reduce serum total-cholesterol levels in vivo.
authors.affiliation: Matsutani Chemical Industry Co. Ltd., Research Institute, Itami, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kishimoto
authors.forename: S
authors.initials: S
authors.lastname: Wakabayashi
authors.forename: H
authors.initials: H
authors.lastname: Takeda
mesh_terms: D000818:Animals; D002784:Cholesterol / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D015918:Infusion Pumps, Implantable; D007263:Infusions, Parenteral; D007275:Injections, Intravenous; D008297:Male; D011422:Propionates / Q000008:administration & dosage / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D011422:Propionates; D002784:Cholesterol; C514135:sodium propionate; C029658:propionic acid