[Mechanisms of cardiac involvement in systemic scleroderma. Apropos of 3 cases].
To investigate myocardial manifestations in progressive systemic sclerosis, we studied three patients with transthoracic echocardiography, cardiac catheterization with coronary angiography, thallium scans with dipyridamol completed by thoracic cold exposure and endomyocardial biopsy with immunohistology. Two patients were symptomatic. In the three cases, abnormalities of myocardial perfusion were detected without coronary stenosis. Two patients had myocardial fibrosis with a coronary spasm in one case. The immunohistological study always showed an unusual expression of HLA class II antigen on cardiac fibroblasts.
Milesi-Lecat
A M
AM
Service de médecine interne, CHRU Nord, Clermont-Ferrand, France.
Aumaitre
O
O
Schmidt
J
J
Cauhapé
P H
PH
Kémény
J L
JL
Francès
C
C
Marcaggi
X
X
Peycelon
P
P
Lusson
J R
JR
Marcheix
J C
JC
D000368:Aged; D001327:Autoimmune Diseases; D001706:Biopsy; D006328:Cardiac Catheterization; D009202:Cardiomyopathies / Q000000981:diagnostic imaging / Q000209:etiology* / Q000503:physiopathology; D003331:Coronary Vessels / Q000473:pathology; D004452:Echocardiography; D004562:Electrocardiography; D005260:Female; D005355:Fibrosis; D006801:Humans; D008297:Male; D008833:Microcirculation; D008875:Middle Aged; D009206:Myocardium / Q000473:pathology; D011877:Radionuclide Imaging; D012595:Scleroderma, Systemic / Q000150:complications* / Q000503:physiopathology