title: Conditioning of the secondary cytotoxic T-lymphocyte response to YC8 tumor.
abstract: Studies from our laboratory demonstrated that conditioned resistance to the syngeneic YC8 lymphoma was established by multiple conditioned stimulus (CS)/unconditioned stimulus (US) associations. The conditioned stimulus used was exposure to the odor of camphor for 1 h and the unconditioned stimulus was an injection of DBA/2 spleen cell alloantigen that shares minor histocompatibility determinants with the YC8 lymphoma. To demonstrate a cellular basis for immune resistance to the YC8 tumor, BALB/c mice primed with DBA/2 spleen cell alloantigen were conditioned using a single trial CS/US association paradigm. Conditioned animals showed a measurable conditioned elevation of the cytotoxic T-lymphocyte (CTL) response to the YC8 tumor. Control groups in which the CS and US were not given in the proper sequence were unable to mount a conditioned response. These studies show that a secondary CTL response can be upregulated by the central nervous system (CNS).
authors.affiliation: Department of Microbiology, University of Alabama at Birmingham, 35294-0007.
authors.forename: V K
authors.initials: VK
authors.lastname: Ghanta
authors.forename: N S
authors.initials: NS
authors.lastname: Hiramoto
authors.forename: S J
authors.initials: SJ
authors.lastname: Soong
authors.forename: R N
authors.initials: RN
authors.lastname: Hiramoto
mesh_terms: D000818:Animals; D002164:Camphor; D003214:Conditioning, Classical / Q000502:physiology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000276:immunology*
chemical_list: D002164:Camphor