Conditioning of the secondary cytotoxic T-lymphocyte response to YC8 tumor.
Studies from our laboratory demonstrated that conditioned resistance to the syngeneic YC8 lymphoma was established by multiple conditioned stimulus (CS)/unconditioned stimulus (US) associations. The conditioned stimulus used was exposure to the odor of camphor for 1 h and the unconditioned stimulus was an injection of DBA/2 spleen cell alloantigen that shares minor histocompatibility determinants with the YC8 lymphoma. To demonstrate a cellular basis for immune resistance to the YC8 tumor, BALB/c mice primed with DBA/2 spleen cell alloantigen were conditioned using a single trial CS/US association paradigm. Conditioned animals showed a measurable conditioned elevation of the cytotoxic T-lymphocyte (CTL) response to the YC8 tumor. Control groups in which the CS and US were not given in the proper sequence were unable to mount a conditioned response. These studies show that a secondary CTL response can be upregulated by the central nervous system (CNS).
Ghanta
V K
VK
Department of Microbiology, University of Alabama at Birmingham, 35294-0007.
Hiramoto
N S
NS
Soong
S J
SJ
Hiramoto
R N
RN
D000818:Animals; D002164:Camphor; D003214:Conditioning, Classical / Q000502:physiology*; D003602:Cytotoxicity, Immunologic; D005260:Female; D008223:Lymphoma / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008811:Mice, Inbred DBA; D013601:T-Lymphocytes / Q000276:immunology*
D002164:Camphor