Evaluation of infection control measures in preventing the nosocomial transmission of multidrug-resistant Mycobacterium tuberculosis in a New York City hospital.
OBJECTIVE
To evaluate the efficacy of Centers for Disease Control and Prevention (CDC)-recommended infection control measures implemented in response to an outbreak of multidrug-resistant (MDR) tuberculosis (TB).


METHODS
Retrospective cohort studies of acquired immunodeficiency syndrome (AIDS) patients and healthcare workers. The study period (January 1989 through September 1992) was divided into period I, before changes in infection control; period II, after aggressive use of administrative controls (eg, rapid placement of TB patients or suspected TB patients in single-patient rooms); and period III, while engineering changes were made (eg, improving ventilation in TB isolation rooms).


METHODS
A New York City hospital that was the site of one of the first reported outbreaks of MDR-TB among AIDS patients in the United States.


METHODS
All AIDS patients admitted during periods I and II. Healthcare workers on nine inpatient units with TB patients and six without TB patients.


RESULTS
The epidemic (38 patients) waned during period II and only one MDR-TB patient presented during period III. The MDR-TB attack rate among AIDS patients hospitalized on the same ward on the same days as an infectious MDR-TB patient was 8.8% (19 of 216) during period I, decreasing to 2.6% (5 of 193; P = 0.01) during period II. In a small group of healthcare workers with tuberculin skin test data, conversions during periods II through III were higher on wards with than without TB patients (5 of 29 versus 0 of 15; P = 0.15), although the difference was not statistically significant.


CONCLUSIONS
Transmission of MDR-TB among AIDS patients decreased markedly after enforcement of readily implementable administrative measures, ending the outbreak. However, tuberculin skin-test conversions among healthcare workers may not have been prevented by these measures. CDC guidelines for prevention of nosocomial transmission of TB should be implemented fully at all US hospitals.
Stroud
L A
LA
Hospital Infections Program, Centers for Disease Control, Atlanta, GA 30033, USA.
Tokars
J I
JI
Grieco
M H
MH
Crawford
J T
JT
Culver
D H
DH
Edlin
B R
BR
Sordillo
E M
EM
Woodley
C L
CL
Gilligan
M E
ME
Schneider
N
N
D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology / Q000517:prevention & control; D002487:Centers for Disease Control and Prevention, U.S.; D015331:Cohort Studies; D003428:Cross Infection / Q000453:epidemiology / Q000517:prevention & control*; D004196:Disease Outbreaks; D017408:Guidelines as Topic; D006786:Hospitals, Urban / Q000592:standards*; D006801:Humans; D017053:Infection Control / Q000379:methods / Q000592:standards*; D009519:New York City / Q000453:epidemiology; D010564:Personnel, Hospital; D012189:Retrospective Studies; D018088:Tuberculosis, Multidrug-Resistant / Q000453:epidemiology / Q000517:prevention & control*; D014481:United States