title: Effect of whole-body hyperthermia on the development of peritumoral brain oedema.
abstract: The effect of whole-body hyperthermia on the development of peritumoral brain oedema and intracranial pressure was studied in cats with intracerebral transplanted tumour. Whole-body hyperthermia was achieved by means of extracorporeal circulation. The temperature within the brain tumour tissue was increased to 41.8 +/- 0.15 degrees C (mean +/- SD) for 2 h. Measurements of brain water content revealed that hyperthermia worsened the degree of peritumoral brain oedema. Microscopical observation demonstrated that extravasation of horseradish peroxidase, indicating disruption of the blood-brain barrier in the oedematous region, was more severe in animals exposed to hyperthermia than in non-treated animals. Intracranial pressure significantly increased from 13.5 +/- 5.26 mmHg to 25.8 +/- 6.16 mmHg (p < 0.05) during hyperthermia, although it was controlled at 20.7 +/- 2.60 mmHg by continuous infusion of glycerol. The results suggest that whole-body hyperthermia acting on a brain-bearing tumour caused an increase in intracranial pressure due to worsening of the degree of peritumoral vasogenic type of brain oedema. We emphasize that whole-body hyperthermia may be performed with careful monitoring of intracranial pressure for patients who have brain tumour.
authors.affiliation: Department of Neurosurgery, Fukui Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hosotani
authors.forename: H
authors.initials: H
authors.lastname: Katsumura
authors.forename: M
authors.initials: M
authors.lastname: Kabuto
authors.forename: Y
authors.initials: Y
authors.lastname: Handa
authors.forename: T
authors.initials: T
authors.lastname: Kubota
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: M ]
authors.initials: M]
authors.lastname: Hayashji M [corrected to Hayashi
mesh_terms: D000818:Animals; D001834:Body Water / Q000378:metabolism; D001929:Brain Edema / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications / Q000628:therapy*; D002415:Cats; D004195:Disease Models, Animal; D005260:Female; D005990:Glycerol / Q000494:pharmacology; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D007427:Intracranial Pressure / Q000187:drug effects; D008297:Male
chemical_list: D005990:Glycerol