[Does aging influence effect of pirenzepine alone or combination of pirenzepine and famotidine on gastric secretion during anesthesia and surgery?].
Effect of pirenzepine alone or the combination of pirenzepine and famotidine on gastric secretion during anesthesia and surgery was evaluated in 52 elective surgical patients ranged in age from 17 to 68 years. These patients of each group were divided into two subgroups according to their age either 40 years and under or over. The patients underwent orthopedic, ophthalmic, ENT, plastic or non-abdominal general surgery under neuroleptanesthesia except 5 patients who had enflurane or isoflurane anesthesia. They received either pirenzepine 10 mg or the combination of pirenzepine 10 mg and famotidine 20 mg intravenously just before the induction of anesthesia. Volume and acidity of gastric juice were measured for 3 hours after the administration of these agents. Decrease in volume and acidity of gastric juice continued for more than 3 hours after the administration of pirenzepine alone or the combination of pirenzepine and famotidine, and it was more prominent in the combination group than in the pirenzepine group. There was no statistical difference in volume of gastric juice between the patients of 40 years and under in age and those over 40 years in each group. However, the intragastric pH tended to be lower in patients of 40 years and under in age than that in those over 40 years. A percentage of patients who had intragastric pH below 2.5 was larger in the pirenzepine administered patients of 40 years and under in age than that of the remaining patients.(ABSTRACT TRUNCATED AT 250 WORDS)
Murakawa
T
T
Department of Anesthesiology, Odate Municipal Hospital.
Ogasawara
E
E
Takahashi
S
S
Sugihara
K
K
Muraoka
M
M
Hirota
K
K
Hashimoto
H
H
Asai
M
M
Matsuki
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000375:Aging / Q000502:physiology*; D003864:Depression, Chemical; D017558:Elective Surgical Procedures; D015738:Famotidine / Q000008:administration & dosage / Q000494:pharmacology*; D005260:Female; D005750:Gastric Juice / Q000378:metabolism*; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D009458:Neuroleptanalgesia; D010890:Pirenzepine / Q000008:administration & dosage / Q000494:pharmacology*
D010890:Pirenzepine; D015738:Famotidine