title: Serum thyrotropin-binding inhibiting immunoglobulin and thyroperoxidase antibody in Graves' hyperthyroidism after 131I therapy.
abstract: Seventeen patients who received radioiodine (131I) therapy for Graves' hyperthyroidism had serial blood samples taken before therapy and after therapy for a period of at least 1 year. At 1 year post-therapy, six patients were hypothyroid. Seven patients were euthyroid, and four patients were hyperthyroid. Prior to isotope administration, 14 patients had detectable serum thyrotropin-binding inhibiting immunoglobulin (TBII) and 16 patients had detectable serum thyroperoxidase antibody (TPOAb). Three to 6 months after therapy, 11 of 14 TBII-positive patients demonstrated a marked increase (> 10%) in serum TBII activity. Four patients out of 11 developed hypothyroidism and six of the 11 developed euthyroidism. A decrease in TBII was observed in three patients who developed hyperthyroidism. In the three patients with undetectable TBII prior to therapy, two had high titers of TPOAb. Seven patients demonstrated a marked increase in TPOAb 3 to 6 months after therapy. Of these, four developed hypothyroidism and three developed euthyroidism, whereas three of the four patients who had a marked decrease in TPOAb developed hyperthyroidism. This study demonstrated that an increase in serum TBII and TPOAb activity 3 to 6 months after 131I therapy, may be useful in predicting which patients may develop euthyroidism or hypothyroidism after 1 year of 131I therapy.
authors.affiliation: Department of Nuclear Medicine and Clinical Pathology, Taipei Municipal Jen-Ai Hospital, Taiwan, R.O.C.
authors.forename: C H
authors.initials: CH
authors.lastname: Hsu
authors.forename: L S
authors.initials: LS
authors.lastname: Lee
authors.forename: J J
authors.initials: JJ
authors.lastname: Chang
authors.forename: S T
authors.initials: ST
authors.lastname: Liao
authors.forename: S M
authors.initials: SM
authors.lastname: Chen
authors.forename: J Y
authors.initials: JY
authors.lastname: Hwang
authors.forename: N I
authors.initials: NI
authors.lastname: Lo
mesh_terms: D000328:Adult; D000368:Aged; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006111:Graves Disease / Q000276:immunology* / Q000532:radiotherapy; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood*; D007453:Iodide Peroxidase / Q000276:immunology*; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D011989:Receptors, Thyrotropin / Q000276:immunology*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D011989:Receptors, Thyrotropin; C056626:thyroid microsomal antibodies; D007453:Iodide Peroxidase