Inflammatory effector mechanisms in asthma.
Each of these effector systems has the capacity to initiate airway obstruction or alter airway responsiveness in asthma. It is likely that they act in concert in certain asthmatic settings. Further basic and applied research will define their relative roles in asthma.
Drazen
J M
JM
Department of Medicine, Brigham and Women's Hospital, Merck Frost Center for Therapeutic Research, Boston, Massachusetts, USA.
Evans
J F
JF
Stevens
R L
RL
Shipp
M A
MA
D001094:Arachidonate 5-Lipoxygenase; D001249:Asthma; D010450:Endopeptidases; D006801:Humans; D008407:Mast Cells / Q000201:enzymology*; D015260:Neprilysin
D001094:Arachidonate 5-Lipoxygenase; D010450:Endopeptidases; D015260:Neprilysin