[Possible relationship between overweightness and prevalence of hyperlipemia in the children of patients with heterozygote familial hypercholesterolemia and combined familial hyperlipemia].
BACKGROUND
Heterozygote familial hypercholesterolemia and combined familial hyperlipemia are associated to a greater risk of coronary disease. Combined familial hyperlipemia has classically been indicated to manifest after the second decade in life. The aim of this study was to establish whether a systematic search would demonstrate the existence of combined familial hyperlipemia earlier and analyze whether the antropometric parameters related with the overweightedness accompany the appearance of the lipid disorders of this disease found at an early age.


METHODS
Different lipid parameters were studied in 89 subjects under the age of 18 who were children of patients with heterozygote familial hypercholesterolemia and combined familial hyperlipemia. Likewise the weight, height and waist/hip quotient were evaluated. Hyperlipemia was considered as the presence of cholesterol/LDL and/or triglicerides greater than the 95 percentile for age and sex.


RESULTS
Hyperlipemia was observed in 51% and 40% of the children of patients with heterozygote familial hypercholesterolemia and combined familial hyperlipemia, respectively. The body mass index and the waist/hip quotient of the latter children significantly correlated with the cholesterol-HDL values and the LDL/HDL quotient.


CONCLUSIONS
The patients with known combined familial hyperlipemia have a high percentage of children with hyperlipemia during infancy. These data suggest a possible association between obesity in the appearance of hyperlipemia in the children of patients with combined familial hyperlipemia at this age.
Jansen
S
S
Unidad de Lípidos, Hospital Reina Sofía, Córdoba.
Zambrana
J L
JL
López Miranda
J
J
Blanco
A
A
Blanco
J
J
Jiménez Perepérez
J A
JA
Espino
A
A
Pérez Jiménez
F
F
D000293:Adolescent; D000886:Anthropometry; D002648:Child; D002675:Child, Preschool; D005260:Female; D006801:Humans; D006950:Hyperlipidemia, Familial Combined; D006949:Hyperlipidemias / Q000150:complications / Q000235:genetics*; D006938:Hyperlipoproteinemia Type II; D007223:Infant; D008297:Male; D009765:Obesity / Q000150:complications / Q000235:genetics*; D015995:Prevalence