Combined radioprotective effect of Broncho-Vaxom and WR-2721 on hemopoiesis and circulating blood cells.
Possibilities of combined radioprotection, using preirradiation WR-2721 administration and post- or preirradiation Broncho-Vaxom administration in lethally whole-body gamma-irradiated mice were investigated. Combined modality treatments were more effective than individual treatments alone. The ameliorative influence of the combined radioprotection could be explained by the hemopoietic stem cell protection with WR-2721 and the stimulation by Broncho-Vaxom.
Macková
N O
NO
Department of Cellular and Molecular Biology, Faculty of Science, P.J. Safárik University, Kosice, Slovakia.
Fedorocko
P
P
D000276:Adjuvants, Immunologic / Q000494:pharmacology*; D004999:Amifostine / Q000494:pharmacology*; D000818:Animals; D001419:Bacteria; D001773:Blood Cells / Q000187:drug effects*; D002457:Cell Extracts; D004359:Drug Therapy, Combination; D005260:Female; D006410:Hematopoiesis / Q000187:drug effects*; D006412:Hematopoietic Stem Cells / Q000187:drug effects; D051379:Mice; D008810:Mice, Inbred C57BL; D011833:Radiation Injuries, Experimental / Q000517:prevention & control*; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D014916:Whole-Body Irradiation / Q000009:adverse effects; D000095983:Bacterial Lysates
D000276:Adjuvants, Immunologic; D004999:Amifostine; D002457:Cell Extracts; D011837:Radiation-Protective Agents; C030259:Broncho-Vaxom; D000095983:Bacterial Lysates