Lymphocyte proliferative response to 2.5 hours of running.
The effect of 2.5 h of treadmill running at 75.6 +/- 0.9% VO2max on circulating leukocyte and lymphocyte subpopulations, epinephrine and cortisol concentrations, and the Con A-induced lymphocyte proliferative response was investigated in 22 experienced marathon runners (VO2max 57.9 +/- 1.1 ml.kg-1.min-1, age 38.7 +/- 1.5 yrs). Blood samples were taken 15 min before (07.15h) and immediately after exercise (10.00h), with three more samples taken during 6h of recovery (11.30, 13.00, 16.00h). Ten sedentary controls (34.7 +/- 1.0 ml.kg-1.min-1, 45.3 +/- 2.3 yrs) sat in the laboratory during testing and had their blood sampled at the same time points. Serum cortisol was elevated relative to controls for more than 3 h post-exercise, and correlated significantly with the 3-h post-exercise, and correlated neutrophil/lymphocyte ratio (r = 0.68, p < 0.001). The concanavalin A- (Con A) induced lymphocyte proliferative response was decreased relative to controls for more than 3 h post-exercise, and except for the immediate post-exercise time point, tended to parallel the decrease in T cell (CD3+) concentrations.
Nieman
D C
DC
Department of Health, Leisure, and Exercise Science, Appalachian State University, USA.
Simandle
S
S
Henson
D A
DA
Warren
B J
BJ
Suttles
J
J
Davis
J M
JM
Buckley
K S
KS
Ahle
J C
JC
Butterworth
D E
DE
Fagoaga
O R
OR
D000328:Adult; D002455:Cell Division; D003208:Concanavalin A / Q000494:pharmacology; D004837:Epinephrine / Q000097:blood; D005080:Exercise Test; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007958:Leukocyte Count; D007962:Leukocytes / Q000502:physiology; D007964:Leukocytosis / Q000473:pathology; D008213:Lymphocyte Activation / Q000187:drug effects / Q000502:physiology*; D016131:Lymphocyte Subsets / Q000166:cytology / Q000502:physiology; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000502:physiology*; D008231:Lymphopenia / Q000473:pathology; D008297:Male; D008875:Middle Aged; D009503:Neutropenia / Q000473:pathology; D009504:Neutrophils / Q000166:cytology / Q000502:physiology; D010101:Oxygen Consumption; D012420:Running / Q000502:physiology*; D013601:T-Lymphocytes / Q000166:cytology / Q000502:physiology
D003208:Concanavalin A; D006854:Hydrocortisone; D004837:Epinephrine