title: Khat chewing and bladder neck dysfunction. A randomized controlled trial of alpha 1-adrenergic blockade.
abstract: OBJECTIVE
  To assess whether the effect of chewing khat leaves (Catha edulis) on the urodynamics of healthy males is altered by the selective alpha 1-adrenergic blocking agent indoramin in a prospective randomized double-blind controlled trial.
  
  
  METHODS
  The urodynamics of 11 healthy males were studied before and during a khat chewing session preceded by indoramin or placebo.
  
  
  RESULTS
  Khat chewing produced a fall in average and maximum urine flow rate. This effect was inhibited by indoramin.
  
  
  CONCLUSIONS
  The urinary side-effects of khat chewing are probably mediated through stimulation of alpha 1-adrenergic receptors.
authors.affiliation: Department of Surgery, Faculty of Medicine, University of Sana'a, Republic of Yemen.
authors.forename: A A
authors.initials: AA
authors.lastname: Nasher
authors.forename: A A
authors.initials: AA
authors.lastname: Qirbi
authors.forename: M A
authors.initials: MA
authors.lastname: Ghafoor
authors.forename: A
authors.initials: A
authors.lastname: Catterall
authors.forename: A
authors.initials: A
authors.lastname: Thompson
authors.forename: J W
authors.initials: JW
authors.lastname: Ramsay
authors.forename: I M
authors.initials: IM
authors.lastname: Murray-Lyon
mesh_terms: D000328:Adult; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004311:Double-Blind Method; D006801:Humans; D007217:Indoramin / Q000494:pharmacology*; D008297:Male; D008875:Middle Aged; D018515:Plant Leaves; D010945:Plants, Edible; D014554:Urination / Q000187:drug effects*; D014563:Urodynamics / Q000187:drug effects
chemical_list: D000697:Central Nervous System Stimulants; D007217:Indoramin