Effect of whole-body hyperthermia on the development of peritumoral brain oedema.
The effect of whole-body hyperthermia on the development of peritumoral brain oedema and intracranial pressure was studied in cats with intracerebral transplanted tumour. Whole-body hyperthermia was achieved by means of extracorporeal circulation. The temperature within the brain tumour tissue was increased to 41.8 +/- 0.15 degrees C (mean +/- SD) for 2 h. Measurements of brain water content revealed that hyperthermia worsened the degree of peritumoral brain oedema. Microscopical observation demonstrated that extravasation of horseradish peroxidase, indicating disruption of the blood-brain barrier in the oedematous region, was more severe in animals exposed to hyperthermia than in non-treated animals. Intracranial pressure significantly increased from 13.5 +/- 5.26 mmHg to 25.8 +/- 6.16 mmHg (p < 0.05) during hyperthermia, although it was controlled at 20.7 +/- 2.60 mmHg by continuous infusion of glycerol. The results suggest that whole-body hyperthermia acting on a brain-bearing tumour caused an increase in intracranial pressure due to worsening of the degree of peritumoral vasogenic type of brain oedema. We emphasize that whole-body hyperthermia may be performed with careful monitoring of intracranial pressure for patients who have brain tumour.
Hosotani
K
K
Department of Neurosurgery, Fukui Medical School, Japan.
Katsumura
H
H
Kabuto
M
M
Handa
Y
Y
Kubota
T
T
Hayashi
M
M
Hayashji M [corrected to Hayashi
M ]
M]
D000818:Animals; D001834:Body Water / Q000378:metabolism; D001929:Brain Edema / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D001932:Brain Neoplasms / Q000150:complications / Q000628:therapy*; D002415:Cats; D004195:Disease Models, Animal; D005260:Female; D005990:Glycerol / Q000494:pharmacology; D006979:Hyperthermia, Induced / Q000009:adverse effects*; D007427:Intracranial Pressure / Q000187:drug effects; D008297:Male
D005990:Glycerol