Expression of progesterone receptor form A and B mRNAs in gynecologic malignant tumors.
This study was designed to examine the biological implication of progesterone receptor (PR) forms A and B mRNA expressions in gynecologic cancers. The ratio of PR form A to form B in mRNA expression was approximately 1:1 in all endometria studied. The predominant expressions of form B transcript occurred in 6 out of 7 cases of advanced stages (stages III and IV) in ovarian cancers, in 5 out of 9 cases of cervical cancers, and in 5 out of 11 cases of endometrial cancers. In conclusions, the dominancy of PR form B mRNA expression might be associated with the expression of a malignant phenotype in gynecologic cancers, and advanced clinical stage in ovarian cancers, suggesting a biological marker of malignant phenotype in these three types of cancer cell.
Fujimoto
J
J
Department of Obstetrics and Gynecology, Gifu University School of Medicine, Japan.
Ichigo
S
S
Hori
M
M
Nishigaki
M
M
Tamaya
T
T
D000328:Adult; D000368:Aged; D001483:Base Sequence; D004717:Endometrium / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D004958:Estradiol / Q000494:pharmacology; D005260:Female; D005347:Fibroblasts / Q000378:metabolism / Q000502:physiology / Q000648:ultrastructure; D005833:Genital Neoplasms, Female / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure*; D006801:Humans; D008597:Menstrual Cycle / Q000502:physiology; D008875:Middle Aged; D008969:Molecular Sequence Data; D010051:Ovarian Neoplasms / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure; D011374:Progesterone / Q000494:pharmacology; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism*; D011980:Receptors, Progesterone / Q000096:biosynthesis* / Q000145:classification* / Q000235:genetics; D012016:Reference Values; D014158:Transcription, Genetic; D002583:Uterine Cervical Neoplasms / Q000648:ultrastructure; D014594:Uterine Neoplasms / Q000235:genetics / Q000378:metabolism / Q000648:ultrastructure
D012333:RNA, Messenger; D011980:Receptors, Progesterone; D011374:Progesterone; D004958:Estradiol