Transient focal cortical hypometabolism in idiopathic West syndrome.
Positron emission tomography (PET) using 18F-labeled 2-deoxy-D-glucose was performed serially in 5 infants with idiopathic West syndrome. While tonic spasms persisted, 2 infants had hypometabolism in the bilateral temporo-parieto-occipital regions, which disappeared after cessation of spasms. In 2 other infants, PET revealed focal hypometabolism in the temporal region a few months after the disappearance of tonic spasms, but subsequent PET studies were normal. PET can detect transient metabolic abnormalities of the cerebral cortex which may be associated with the pathophysiology of West syndrome.
Maeda
N
N
Department of Pediatrics, Nagoya University School of Medicine, Japan.
Watanabe
K
K
Negoro
T
T
Aso
K
K
Haga
Y
Y
Kito
M
M
Ohki
T
T
Ito
K
K
Kato
T
T
D001786:Blood Glucose / Q000378:metabolism*; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000187:drug effects / Q000503:physiopathology; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004292:Dominance, Cerebral / Q000187:drug effects / Q000502:physiology; D004569:Electroencephalography / Q000187:drug effects; D005071:Evoked Potentials / Q000187:drug effects / Q000502:physiology; D005260:Female; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007223:Infant; D008297:Male; D013036:Spasms, Infantile / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000503:physiopathology; D014055:Tomography, Emission-Computed
D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose