Increase of release of neuropeptide Y in vitro from platelets of spontaneously hypertensive rats.
OBJECTIVE
To investigate the pathophysiological role of platelet neuropeptide Y (NPY) in hypertension.


METHODS
The content of NPY in plasma and platelets from spontaneously hypertensive rats (SHR) and Wistar-Kyoto rats (WKR) were measured by radioimmunoassay.


RESULTS
There was no difference in NPY concentration between SHR plasma and WKR plasma (2.1 +/- 1.0 vs 1.8 + 1.0 microgram.L-1), but higher amounts of NPY in SHR platelets than in WKR platelets (32 +/- 6 vs 22 +/- 9 micrograms.L-1, P < 0.05). The platelet aggregation and the release of NPY from platelets induced by thrombin and collagen were increased in SHR; ADP did not cause NPY release from platelets, although it produced severe aggregation in both SHR and WKR.


CONCLUSIONS
The content of NPY in platelets and thrombin- and collagen-induced NPY release from platelets are higher in SHR than in WKR.
Chen
S H
SH
Institute of Vascular Medicine, Third Hospital, Beijing Medical University, China.
Han
Q D
QD
D000818:Animals; D001792:Blood Platelets / Q000737:chemistry*; D006973:Hypertension / Q000097:blood*; D008297:Male; D009478:Neuropeptide Y / Q000097:blood*; D010974:Platelet Aggregation; D011863:Radioimmunoassay; D051381:Rats; D011918:Rats, Inbred SHR; D011921:Rats, Inbred WKY
D009478:Neuropeptide Y