Endothelial cells injured by oxidized low density lipoprotein.
Cultured endothelial cells from bovine aorta were exposed to oxidized low density lipoprotein and examined by electron microscopy. The endothelial cells contracted slightly and the intercellular junctions became unclear. Some osmiophilic material increased in the cytoplasm. The oxidized low density lipoprotein appears to injure endothelial cells and thereby plays a causative role in atherogenesis and thrombogenesis.
Zhao
B
B
Platelet Research Unit, University of Muenster, Germany.
Zhang
Y
Y
Liu
B
B
Nawroth
P
P
Dierichs
R
R
D000818:Animals; D001011:Aorta; D002417:Cattle; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000648:ultrastructure; D007365:Intercellular Junctions / Q000648:ultrastructure; D008077:Lipoproteins, LDL / Q000494:pharmacology*; D008854:Microscopy, Electron; D015388:Organelles / Q000648:ultrastructure; D010084:Oxidation-Reduction
D008077:Lipoproteins, LDL