title: Delay times in the administration of thrombolytic therapy: the Brighton experience.
abstract: We reviewed the effectiveness of a strategy involving paramedic ambulances and community education to reduce the delay to thrombolytic therapy in patients admitted with acute myocardial infarction, by analysing delay times recorded during routine treatment. Rapid identification and treatment of patients with acute myocardial infarction who were eligible for thrombolysis was carried out in the Accident and Emergency and Cardiac Care Units. Two hundred seventy-four patients were admitted with acute myocardial infarction over an 18-month period and treated with anistreplase (168) or streptokinase (106). The following median times were recorded: symptom onset to administration of thrombolytic therapy, 142 min (range 43-980 min); symptom onset to ambulance arrival, 60 min; ambulance with patient to arrival in hospital, 35 min; time to treatment in hospital ('door to needle time'), 25 min; in-hospital delays were notably shorter for patients given anistreplase as opposed to streptokinase. Shortened delays for the delivery of thrombolytic therapy can be achieved by a strategy involving public education, the availability of resuscitation ambulances, and close liaison with the Accident and Emergency Department.
authors.affiliation: Department of Cardiology, Royal Sussex County Hospital, Brighton, UK.
authors.forename: R
authors.initials: R
authors.lastname: More
authors.forename: K
authors.initials: K
authors.lastname: Moore
authors.forename: E
authors.initials: E
authors.lastname: Quinn
authors.forename: C
authors.initials: C
authors.lastname: Perez Avila
authors.forename: C
authors.initials: C
authors.lastname: Davidson
authors.forename: R
authors.initials: R
authors.lastname: Vincent
authors.forename: D
authors.initials: D
authors.lastname: Chamberlain
mesh_terms: D000552:Ambulances; D016255:Anistreplase / Q000008:administration & dosage; D004631:Emergency Medical Service Communication Systems; D004632:Emergency Medical Services / Q000379:methods / Q000458:organization & administration*; D004739:England; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006801:Humans; D009203:Myocardial Infarction / Q000188:drug therapy*; D010353:Patient Education as Topic; D015397:Program Evaluation; D013300:Streptokinase / Q000008:administration & dosage; D015912:Thrombolytic Therapy / Q000379:methods*; D013997:Time Factors; D014218:Triage
chemical_list: D005343:Fibrinolytic Agents; D016255:Anistreplase; D013300:Streptokinase