[Changes in lipids, bilirubin and metal elements in the gallbladder bile in patients with cirrhosis of the liver].
The aim of this study is to observe the changes of bile elements in patients with cirrhosis of liver and to analyse the relationship with stone formation. The gallbladder bile in 24 patients with cirrhosis of liver was obtained with aspiration during operation. The levels of lipids, bilirubin and various metal elements such as potassium, sodium, calcium, magnesium, copper, iron, and zinc in the bile were determined. Elevated unconjugated bilirubin (UCB) level (P < 0.02) and decreased levels of total bile acid (TBA) (P < 0.001), total cholesterol (TC) (P < 0.001), phospholipids (PL) (P < 0.05) and bile viscosity (P < 0.001) were found. The levels of potassium, magnesium, copper and zinc in the bile decreased (all P values less than 0.001), while the level of iron increased (P < 0.02) significantly in cirrhotic patients. The results showed that there is an obvious tendency for gallbladder bile in cirrhotic patients to form pigment stones.
Zhu
J F
JF
General Hospital of Jinan Unit of People's Liberation Army.
Shan
L C
LC
Chen
W H
WH
D000293:Adolescent; D000328:Adult; D001646:Bile / Q000737:chemistry*; D001663:Bilirubin / Q000378:metabolism*; D002769:Cholelithiasis / Q000209:etiology*; D002784:Cholesterol / Q000378:metabolism*; D005260:Female; D006801:Humans; D007501:Iron / Q000378:metabolism*; D008103:Liver Cirrhosis / Q000150:complications / Q000378:metabolism*; D008274:Magnesium / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000378:metabolism
D002784:Cholesterol; D007501:Iron; D008274:Magnesium; D001663:Bilirubin; D011188:Potassium