title: Effect of prolonged exercise on neutrophil myeloperoxidase secretion.
abstract: This study was designed to compare the effects of three prolonged exercises on plasma myeloperoxidase concentrations, used as marker of neutrophil degranulation. Seven healthy subjects underwent three effort trials (45% VO2max during 4 h, 60% VO2max during 3 h, 75% VO2max during 2 h) at one-month intervals. Blood samples were collected before, during and after exercise. Myeloperoxidase levels were measured by radioimmunoassay. We observed a significant increase in myeloperoxidase concentration (+85%) at the end of our three prolonged exercises (p < 0.05). This myeloperoxidase increase was not correlated with the modification of neutrophil count, suggesting that neutrophil degranulation is independent of their mobilisation.
authors.affiliation: Department of Pneumology, CHU Sart-Tilman, Liege, Belgium.
authors.forename: T B
authors.initials: TB
authors.lastname: Bury
authors.forename: F
authors.initials: F
authors.lastname: Pirnay
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D015550:Cell Degranulation; D005080:Exercise Test; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D018375:Neutrophil Activation; D009504:Neutrophils / Q000201:enzymology* / Q000502:physiology; D010101:Oxygen Consumption; D009195:Peroxidase / Q000097:blood* / Q000378:metabolism; D005082:Physical Exertion / Q000502:physiology*
chemical_list: D009195:Peroxidase