Coexpression of trk family members and low-affinity neurotrophin receptors in rat dorsal root ganglion neurons.
We examined the colocalization of trk family and low-affinity neurotrophin receptor (LANR) mRNAs by means of in situ hybridization histochemistry in rat dorsal root ganglion (DRG) neurons. About 35-40%, 5%, and 15-20% of DRG neurons were positive for trkA, trkB, and trkC mRNAs, respectively. Each member of the trk family was coexpressed with LANR. The trkB mRNA-expressing neurons essentially lacked trkA and trkC mRNAs, and most of trkA and trkC mRNAs-expressing neurons (85-90%) belonged to different subpopulations, suggesting that they are involved in different functions.
Kashiba
H
H
Department of Physiology, Kansai College of Oriental Medicine, Osaka, Japan.
Noguchi
K
K
Ueda
Y
Y
Senba
E
E
D000818:Animals; D017868:Cyclic AMP-Dependent Protein Kinases / Q000096:biosynthesis / Q000235:genetics; D005727:Ganglia, Spinal / Q000166:cytology / Q000201:enzymology*; D015870:Gene Expression; D017403:In Situ Hybridization; D008297:Male; D009474:Neurons / Q000201:enzymology / Q000378:metabolism; D011493:Protein Kinase C / Q000096:biosynthesis / Q000235:genetics; D011505:Protein-Tyrosine Kinases / Q000096:biosynthesis* / Q000235:genetics; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar
D012333:RNA, Messenger; D011505:Protein-Tyrosine Kinases; D017868:Cyclic AMP-Dependent Protein Kinases; D011493:Protein Kinase C