[A study on serum autoantibodies against inner ear tissue in the blood of patients with inner ear disorders of unknown etiology].
Membranous labyrinth antigen of guinea pigs was prepared. The sera of 33 patients with inner ear disorders of unknown etiology were examined by immunoblotting assay. The autoantibodies against inner ear antigen were found in patient's sera (30.3%). This indicated that the autoimmune activity may play a role in the development of some cases of these diseases. The detection of autoantibodies to inner ear antigen will be of great value to further study on the action of autoimmunological factor contributing to inner ear disorders of unknown etiology.
Xiao
H
H
Union Hospital, Tongji Medical University, Wuhan.
Gong
S
S
Wang
J
J
D000293:Adolescent; D000328:Adult; D001323:Autoantibodies / Q000097:blood*; D007758:Ear, Inner / Q000276:immunology; D005260:Female; D006319:Hearing Loss, Sensorineural / Q000276:immunology*; D003639:Hearing Loss, Sudden / Q000276:immunology; D006801:Humans; D015151:Immunoblotting; D008297:Male; D008575:Meniere Disease / Q000276:immunology*; D008875:Middle Aged
D001323:Autoantibodies