The effect of nitric oxide donors on the release of plasminogen activator inhibitor (PAI) from rabbit platelets in vitro.
Here we describe effects of four nitric oxide (NO) donors, 4-arylsubstituted oxatriazol derivatives and 3-morpholino-sydnonimine (SIN-1) at concentrations of 30-1000 microM on the release of plasminogen activator inhibitor (PAI) from rabbit platelets in vitro. At 37 degrees C, pH of 7.4 and a concentration of 30 microM, all compounds released NO as measured by the Werringloer's technique. The NO-generating potency of the compounds correlated with their capacity to inhibit the release of PAI from platelets and both phenomena were concentration-dependent. We conclude that various types of NO-donors activate plasma fibrinolytic system through inhibition of the release of PAI from platelets.
Korbut
R
R
Department of Pharmacology, Medical College of Jagiellonian University, Cracow, Poland.
Marcinkiewicz
E
E
Cieślik
K
K
Gryglewski
R J
RJ
D000818:Animals; D001792:Blood Platelets / Q000378:metabolism*; D002478:Cells, Cultured; D008981:Molsidomine / Q000031:analogs & derivatives / Q000494:pharmacology; D009569:Nitric Oxide / Q000819:agonists* / Q000097:blood; D015849:Plasminogen Inactivators / Q000097:blood*; D011817:Rabbits / Q000097:blood; D014230:Triazoles / Q000494:pharmacology
C094434:GEA 3198; C094435:GEA 5016; D015849:Plasminogen Inactivators; D014230:Triazoles; D009569:Nitric Oxide; C002385:linsidomine; D008981:Molsidomine