title: Fracture blister formation: a laboratory study.
abstract: A biomechanical study was performed to examine a proposed mechanism of fracture blister formation. Sixty cadaver ankle skin specimens were subjected to several levels of uniaxial strain and examined histologically. Dermal-epidermal separation patterns similar to those found histologically in previous studies of biopsied fracture blisters were seen in specimens strained 152% and greater. These findings support the hypothesis that fracture blisters can result from strain developed in the skin during initial fracture deformation.
authors.affiliation: Hospital for Joint Diseases, Orthopaedic Institute, New York, New York 10003, USA.
authors.forename: C P
authors.initials: CP
authors.lastname: Giordano
authors.forename: D
authors.initials: D
authors.lastname: Scott
authors.forename: K J
authors.initials: KJ
authors.lastname: Koval
authors.forename: F
authors.initials: F
authors.lastname: Kummer
authors.forename: T
authors.initials: T
authors.lastname: Atik
authors.forename: P
authors.initials: P
authors.lastname: Desai
mesh_terms: D001696:Biomechanical Phenomena; D001768:Blister / Q000209:etiology* / Q000473:pathology; D050723:Fractures, Bone / Q000150:complications*; D006801:Humans; D012867:Skin / Q000473:pathology*