Autoimmune diabetes and its antigenic triggers.
Susceptibility to insulin-dependent disease is largely determined by alterations in an HLA gene. In addition to insulin, several other antigenic triggers have been identified. One of these, glutamic acid decarboxylase-65, appears to be a primary trigger and may be a key to future treatment. Experimentally, intrathymic or intravenous injection of GAD-65 dampens the autoimmune response and delays disease.
McDevitt
H O
HO
Department of Microbiology and Immunology, Stanford University School of Medicine, USA.
D000818:Animals; D000941:Antigens / Q000276:immunology*; D001327:Autoimmune Diseases / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D003920:Diabetes Mellitus / Q000209:etiology / Q000235:genetics / Q000276:immunology*; D003921:Diabetes Mellitus, Experimental / Q000209:etiology / Q000276:immunology; D006683:HLA-DQ Antigens / Q000235:genetics; D006801:Humans; D008285:Major Histocompatibility Complex / Q000276:immunology; D051379:Mice; D016688:Mice, Inbred NOD
D000941:Antigens; D006683:HLA-DQ Antigens