Prognostic significance of nucleolar organizer regions in recurrent pleomorphic adenomas of salivary glands.
Pleomorphic adenoma (PA) is the commonest tumor of salivary glands. It is considered a benign tumor which may recur and rarely metastatize. There are no reliable histological criteria for predicting recurrences of PA. In this paper, Ag-NOR expression, evaluated by means a computer assisted image analysis system, has been tested on 11 cases of PA, their recurrences, 10 non recurrent PA and 5 cases of carcinoma ex PA. Mean AgNOR count, mean AgNOR area and mean AgNOR area/particle were determined in each group. AgNOR count and area did not show any significant differences between recurrent and non recurrent PA. On the contrary, AgNOR area/particle seems to be a useful tool in predicting the clinical behaviour of this lesion.
Criscuolo
M
M
Dipartimento di Scienze Morfologiche e Medico Legali, Università di Modena, Italia.
Migaldi
M
M
Collina
G
G
Cesinaro
A M
AM
Galetti
R
R
Lo Bianco
F
F
Trentini
G P
GP
D008949:Adenoma, Pleomorphic / Q000473:pathology*; D000293:Adolescent; D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000473:pathology*; D009697:Nucleolus Organizer Region / Q000473:pathology*; D011379:Prognosis; D012468:Salivary Gland Neoplasms / Q000473:pathology*