title: Maternal HLA-DR homozygosity is not associated with an increased risk of fetal loss.
abstract: An attractive but controversial hypothesis holds that HLA similarity between mother and offspring predisposes to early fetal loss. Against this background, Hoff et al. (1992) have reported a significant association between maternal HLA-DR homozygosity and fetal loss in a cohort of multigravid American women. To re-examine this finding independently, a similar investigation was carried out on a comparable group of British subjects. The HLA-DR data of 75 multigravid women were analysed: the proportion of women who had experienced fetal loss did not differ between HLA-DR homozygous and heterozygous subjects.
authors.affiliation: Department of Transfusion Medicine, The Royal Infirmary, Edinburgh, Scotland.
authors.forename: D C
authors.initials: DC
authors.lastname: Kilpatrick
mesh_terms: D000022:Abortion, Spontaneous / Q000209:etiology*; D005260:Female; D006684:HLA-DR Antigens / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D011247:Pregnancy; D012306:Risk
chemical_list: D006684:HLA-DR Antigens