title: Scintimammography: the complementary role of Tc-99m sestamibi prone breast imaging for the diagnosis of breast carcinoma.
abstract: OBJECTIVE
  To evaluate the complementary role of technetium-99m sestamibi scintimammography in improvement of the sensitivity and specificity of mammography in detection of carcinoma of the breast.
  
  
  METHODS
  At 5 and 60 minutes after intravenous injection of Tc-99m sestamibi, scintimammograms were obtained in 147 women (age range, 18-73 years; mean age, 47.9 years +/- 10.2 [standard deviation]) with 153 lesions that warranted breast biopsy (102 lesions) or fine-needle aspiration cytologic analysis (51 lesions). There were 113 palpable and 40 nonpalpable lesions. Lesion size on mammograms was 0.8 x 0.6 cm to 15.0 x 11.0 cm (mean, 2.82 cm +/- 1.71 x 2.39 cm +/- 1.56).
  
  
  RESULTS
  Scintimammographic findings were true-positive in 47 biopsy-confirmed carcinomas, true-negative in 91 benign lesions, false-positive in 11 lesions with benign histopathologic findings (fibrocystic disease [n = 8] or fibroadenoma [n = 3]), and false-negative in four lesions of infiltrating ductal carcinoma. The sensitivity of scintimammography was 92.2%; specificity, 89.2%; positive predictive value, 81.0%; and negative predictive value, 95.8%.
  
  
  CONCLUSIONS
  The authors conclude that scintimammography is a sensitive test that can improve the detection of breast carcinoma.
authors.affiliation: Department of Radiology, Harbor-University of California Los Angeles (UCLA) Medical Center, Torrance 90502, USA.
authors.forename: I
authors.initials: I
authors.lastname: Khalkhali
authors.forename: J A
authors.initials: JA
authors.lastname: Cutrone
authors.forename: I G
authors.initials: IG
authors.lastname: Mena
authors.forename: L E
authors.initials: LE
authors.lastname: Diggles
authors.forename: R J
authors.initials: RJ
authors.lastname: Venegas
authors.forename: H I
authors.initials: HI
authors.lastname: Vargas
authors.forename: B L
authors.initials: BL
authors.lastname: Jackson
authors.forename: S
authors.initials: S
authors.lastname: Khalkhali
authors.forename: J F
authors.initials: JF
authors.lastname: Moss
authors.forename: S R
authors.initials: SR
authors.lastname: Klein
mesh_terms: D001707:Biopsy, Needle; D001940:Breast / Q000473:pathology; D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging* / Q000473:pathology; D018270:Carcinoma, Ductal, Breast / Q000000981:diagnostic imaging* / Q000473:pathology; D005188:False Negative Reactions; D005189:False Positive Reactions; D005260:Female; D005348:Fibrocystic Breast Disease / Q000000981:diagnostic imaging / Q000473:pathology; D006801:Humans; D008875:Middle Aged; D011237:Predictive Value of Tests; D016684:Prone Position; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D017256:Technetium Tc 99m Sestamibi
chemical_list: D017256:Technetium Tc 99m Sestamibi