title: The role of surgery in the management of pediatric pelvic rhabdomyosarcoma.
abstract: OBJECTIVE
  We assessed the role of surgery, particularly exenteration, in the treatment of children with lower urinary tract and pelvic rhabdomyosarcoma.
  
  
  METHODS
  We treated 23 children with bladder and/or prostate (11), or pelvic retroperitoneal tumors (12). Initial management was tumor resection in 6 cases, anterior pelvic exenteration in 5 and biopsy only in 12, combined with chemotherapy in 23 and radiotherapy in 20.
  
  
  RESULTS
  The bladder salvage rate for surviving patients with pelvic tumors was 92% versus 27% for those with prostate/bladder tumors. Estimated 5 and 10-year survival probability for patients with pelvic retroperitoneal tumors was 49 +/- 50% compared to 81 +/- 24% for those with bladder and/or prostate tumors (log rank test, p = 0.11).
  
  
  CONCLUSIONS
  Exenterative surgery is frequently required to achieve a durable complete response.
authors.affiliation: Scott Department of Urology, Baylor College of Medicine, Houston, Texas, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Lerner
authors.forename: A
authors.initials: A
authors.lastname: Hayani
authors.forename: P
authors.initials: P
authors.lastname: O'Hollaren
authors.forename: C
authors.initials: C
authors.lastname: Winkel
authors.forename: M
authors.initials: M
authors.lastname: Ohori
authors.forename: F J
authors.initials: FJ
authors.lastname: Harberg
authors.forename: D R
authors.initials: DR
authors.lastname: Roth
authors.forename: E T
authors.initials: ET
authors.lastname: Gonzales
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D002648:Child; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000453:epidemiology; D010386:Pelvic Neoplasms / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D011471:Prostatic Neoplasms / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D012186:Retroperitoneal Neoplasms / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D012189:Retrospective Studies; D012208:Rhabdomyosarcoma / Q000188:drug therapy / Q000401:mortality / Q000532:radiotherapy / Q000601:surgery*; D015996:Survival Rate; D001749:Urinary Bladder Neoplasms / Q000401:mortality / Q000601:surgery* / Q000628:therapy; D014547:Urinary Diversion