Taxuspine D, a new taxane diterpene from Taxus cuspidata with potent inhibitory activity against Ca(2+)-induced depolymerization of microtubules.
A new taxane diterpenoid, taxuspine D (1), possessing an enolacetate moiety, has been isolated from stems of the Japanese yew Taxus cuspidata Sieb. et Zucc., and the structure elucidated on the basis of spectroscopic data. Taxuspine D (1) markedly inhibited Ca(2+)-induced depolymerization of microtubules.
Kobayashi
J
J
Faculty of Pharmaceutical Sciences, Hokkaido University, Sapporo, Japan.
Hosoyama
H
H
Shigemori
H
H
Koiso
Y
Y
Iwasaki
S
S
D002118:Calcium / Q000494:pharmacology; D008870:Microtubules / Q000187:drug effects; D017239:Paclitaxel / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000378:metabolism / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*; D043823:Taxoids; D014404:Tubulin / Q000378:metabolism
D043823:Taxoids; D014404:Tubulin; C094551:taxuspine D; D017239:Paclitaxel; D002118:Calcium