Association of Helicobacter pylori and gastric autoimmunity: a population-based study.
Based on clinical studies, a negative association between Helicobacter pylori and autoimmune corpus gastritis is described. In the present investigation of an unselected population of 1461 adults we can state, however, that there exists a relationship between H. pylori infection and the development of gastric corpus autoimmunity. As confirmation for the gastric autoantibody development through molecular mimicry, a high homology (72% in 25 amino acid overlap) between the beta subunit of H. pylori urease and that of H + K + ATPase, the gastric parietal cell autoantigen, was revealed.
Uibo
R
R
Institute of General and Molecular Pathology, University of Tartu, Estonia.
Vorobjova
T
T
Metsküla
K
K
Kisand
K
K
Wadström
T
T
Kivik
T
T
D000293:Adolescent; D000328:Adult; D000368:Aged; D000595:Amino Acid Sequence; D000818:Animals; D000942:Antigens, Bacterial / Q000235:genetics; D001323:Autoantibodies / Q000097:blood; D001324:Autoantigens / Q000235:genetics; D001327:Autoimmune Diseases / Q000382:microbiology*; D015331:Cohort Studies; D004957:Estonia; D005260:Female; D005756:Gastritis / Q000276:immunology / Q000382:microbiology*; D017506:H(+)-K(+)-Exchanging ATPase / Q000235:genetics; D016481:Helicobacter Infections / Q000276:immunology*; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D008297:Male; D051379:Mice; D008875:Middle Aged; D008969:Molecular Sequence Data; D010295:Parietal Cells, Gastric / Q000201:enzymology / Q000276:immunology; D051381:Rats; D017386:Sequence Homology, Amino Acid; D014510:Urease / Q000235:genetics
D000942:Antigens, Bacterial; D001323:Autoantibodies; D001324:Autoantigens; D007074:Immunoglobulin G; D014510:Urease; D017506:H(+)-K(+)-Exchanging ATPase