Targeting ticks for control of selected hemoparasitic diseases of cattle.
Development in and transmission of hemoparasites by tick vectors are phenomena closely synchronized with the tick feeding cycle. In all known life cycles, initial infection of tick tissues occurs in midgut epithelial cells and transmission is effected as ticks feed after parasites have developed and multiplied in salivary glands. Many factors reviewed affect development and transmission of hemoparasites by ticks including age of ticks, artificial temperature, climate and/or season, tick stage or sex, hemoparasite variation, concurrent infection of ticks with other pathogens, host cell susceptibility, transovarial transmission, effect of hemoparasites on tick biology, and the effect of infecting parasitemia level in cattle on infection rates in ticks. Four hemoparasites of cattle, Anaplasma marginale, Cowdria ruminantium, Theileria parva, and Babesia spp., are all dependent on ticks for biological transmission. Babesia is transmitted transovarially whereas the other three are transmitted transstadially. Mechanical transfer of infective blood via fomites and mouthparts of biting arthropods is also a major means of transmission for Anaplasma marginale but not of the others. Potential control methods for hemoparasites that target parasites as they are developing in their respective tick hosts include tick control, vaccines (against ticks and parasites), and drugs (against ticks and parasites). Successful application of control strategies will be dependent upon thorough understanding of parasite developmental cycles, biology of the tick vectors and the immune response of cattle to ticks and to hemoparasites. The most effective control measures will be those that are targeted against both ticks and the hemoparasites they vector.
Kocan
K M
KM
Department of Veterinary Pathology, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078, USA.
D000818:Animals; D016793:Babesia bovis; D001404:Babesiosis / Q000517:prevention & control / Q000635:transmission; D001424:Bacterial Infections / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D002417:Cattle; D002418:Cattle Diseases / Q000517:prevention & control*; D003870:Dermacentor / Q000382:microbiology; D005260:Female; D008297:Male; D013983:Tick Control; D017282:Tick-Borne Diseases / Q000517:prevention & control / Q000635:transmission / Q000662:veterinary*; D013987:Ticks / Q000254:growth & development / Q000382:microbiology / Q000469:parasitology