Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin.
Posner
G H
GH
Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Wang
D
D
Cumming
J N
JN
Oh
C H
CH
French
A N
AN
Bodley
A L
AL
Shapiro
T A
TA
D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D037621:Artemisinins; D002244:Carbon / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000962:Antimalarials; D037621:Artemisinins; D006571:Heterocyclic Compounds; D012717:Sesquiterpenes; D002244:Carbon; C031327:artemisinin