Co-occurrence of perineuronal nets with GABAA receptor alpha 1 subunit-immunoreactive neurones in the rat septal region.
The immunocytochemical demonstration of the GABAA receptor alpha 1 subunit was combined with the Wisteria floribunda agglutinin staining of lattice-like extracellular matrix components--known as perineuronal nets--in the rat basal forebrain. Both were found to be co-localized in the septal-diagonal band region (e.g. in the medial septum, 96%), but only exceptionally in the ventral pallidum (3-10%) and nowhere in other basal forebrain subdivisions. This co-occurrence of perineuronal nets with septo-hippocampal projection neurones--previously characterized as GABAergic--expressing the GABAA receptor alpha 1 subunit- as well as parvalbumin-immunoreactivity, suggests the involvement of these intra- and extraneuronal components in the fast spiking neuronal activity essential for the generation and maintenance of hippocampal theta rhythm.
Brauer
K
K
Department of Neuroanatomy, University of Leipzig, Germany.
Härtig
W
W
Fritschy
J M
JM
Brückner
G
G
Bigl
V
V
D000818:Animals; D007150:Immunohistochemistry; D037102:Lectins; D008297:Male; D009415:Nerve Net / Q000166:cytology*; D009474:Neurons / Q000737:chemistry* / Q000648:ultrastructure; D010320:Parvalbumins / Q000032:analysis; D010446:Peptide Fragments / Q000032:analysis*; D037121:Plant Lectins; D051381:Rats; D017208:Rats, Wistar; D011963:Receptors, GABA-A / Q000032:analysis*; D034781:Receptors, N-Acetylglucosamine; D012688:Septum Pellucidum / Q000737:chemistry* / Q000166:cytology
D037102:Lectins; D010320:Parvalbumins; D010446:Peptide Fragments; D037121:Plant Lectins; D011963:Receptors, GABA-A; D034781:Receptors, N-Acetylglucosamine; C040129:wisteria lectin