title: Clinicopathological features of MERRF.
abstract: Clinical features of MERRF are varied in terms of patterns and severity of symptoms at the early stage. The age of onset differs even in the same family. Occasionally, ragged-red fibers are not found upon the muscle biopsy. Pathological features in some patients are very mild in comparison with their clinical symptoms; genetic analysis is needed for diagnosis. Unique clinical features in members of three families with MERRF are reported.
authors.affiliation: Department of Neurology, National Saigata Hospital, Niigata, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Fukuhara
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001284:Atrophy; D001921:Brain / Q000473:pathology; D002648:Child; D005260:Female; D006801:Humans; D017243:MERRF Syndrome / Q000235:genetics / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009154:Mutation; D010375:Pedigree; D013116:Spinal Cord / Q000473:pathology