Possible evidence of angiotensin II and endogenous opioid modulation of novelty-induced rearing in the rat.
Rats treated with captopril (CAP, 10mg/kg i.p.) naltrexone (Nalx 0.1 mg/kg i.p) and saralasine (100 micrograms/kg i.p) displayed significantly less novelty-induced rearing (NIR) compared to saline injected animals. Naltrexone potentiated the inhibitory effect of CAP on NIR. Pretreatment with NALX did not alter SARA-induced decrease in NIR. It is suggested that the endogenous release of AII and/or opioids somehow modulate basal rearing activity.
Ajayi
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Department of Medicine, Obafemi Awolowo University, Ile-Ife, Nigeria.
Ukponmwan
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OE
D000804:Angiotensin II / Q000187:drug effects / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D001143:Arousal / Q000187:drug effects; D002216:Captopril / Q000494:pharmacology*; D004357:Drug Synergism; D005106:Exploratory Behavior / Q000187:drug effects*; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009271:Naltrexone / Q000494:pharmacology; D018847:Opioid Peptides / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D011919:Rats, Inbred Strains; D012504:Saralasin / Q000494:pharmacology*
D018847:Opioid Peptides; D000804:Angiotensin II; D009271:Naltrexone; D002216:Captopril; D012504:Saralasin