title: Training effects on the hydromineral endocrine responses of cardiac transplant patients.
abstract: Cardiac transplant patients manifest several haemodynamic changes as well as altered peripheral responses to exercise which may disrupt body fluid regulation. This study examined the effect on an endurance training programme on the exercise-induced hydromineral endocrine responses of heart transplant patients. Seven patients underwent a square-wave exercise test before and after a 6-week training programme. The tests were performed at the same absolute intensity but, during training, the workload was increased to maintain the same relative exercise intensity. Pretraining results were compared to those obtained from age-matched controls. Training improved physical capacity, producing a significant increase in maximal tolerated power and workload between the first and last training session (P < 0.05, P < 0.001, respectively). Haematocrit and osmolality were increased in both groups at the end of exercise (P < 0.01) but changes observed post-training did not differ from pretraining values. Apart from atrial natriuretic peptide (ANP), which showed significantly higher concentrations at rest and during exercise (P < 0.01), the changes in hydromineral hormones of the patients resembled those of the controls. Basal plasma renin activity (PRA) was slightly raised prior to training (P < 0.07) compared to the controls and post-training. For both PRA and aldosterone, a significant training effect was revealed when both the exercise-stimulated increase and postexercise decline were considered (P < 0.05), possibly reflecting lower noradrenaline concentrations. Training had no effect on either basal or exercise stimulated ANP levels, which is compatible with the theory that ANP regulation is largely under mechanical rather than sympathetic nervous system control.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Laboratoire de Physiologie et de Psychologie Environnementales, CNRS-LPPE., Strasbourg, France.
authors.forename: J
authors.initials: J
authors.lastname: Saini
authors.forename: B
authors.initials: B
authors.lastname: Geny
authors.forename: G
authors.initials: G
authors.lastname: Brandenberger
authors.forename: B
authors.initials: B
authors.lastname: Mettauer
authors.forename: G
authors.initials: G
authors.lastname: Wittersheim
authors.forename: E
authors.initials: E
authors.lastname: Lampert
authors.forename: J
authors.initials: J
authors.lastname: Lonsdorfer
mesh_terms: D000328:Adult; D000450:Aldosterone / Q000097:blood; D001127:Arginine Vasopressin / Q000097:blood; D009320:Atrial Natriuretic Factor / Q000097:blood; D015444:Exercise / Q000502:physiology*; D005260:Female; D016027:Heart Transplantation / Q000534:rehabilitation*; D006728:Hormones / Q000097:blood*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D010807:Physical Endurance / Q000502:physiology*; D012083:Renin / Q000097:blood; D013997:Time Factors
chemical_list: D006728:Hormones; D001127:Arginine Vasopressin; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012083:Renin