title: Ketamine does not increase cerebral blood flow velocity or intracranial pressure during isoflurane/nitrous oxide anesthesia in patients undergoing craniotomy.
abstract: Ketamine's effect on cerebral hemodynamics is controversial. We hypothesized that ketamine would not increase intracranial pressure (ICP) and cerebral blood flow (CBF) velocity in anesthetized, ventilated patients. Twenty patients requiring craniotomy for brain tumor or cerebral aneurysm were studied. After induction with thiopental, anesthesia was maintained with isoflurane and nitrous oxide in oxygen. During controlled ventilation (PaCO2 34 +/- 1 mm Hg); middle cerebral artery blood flow velocity (VMCA), mean arterial blood pressure (MAP), bilateral frontooccipital processed electroencephalogram (EEG), and ICP were measured before and for 10 min after intravenous ketamine 1.0 mg/kg. Cerebral arteriovenous oxygen content difference (AVDO2) and cerebral perfusion pressure (CPP) were calculated. After ketamine, MAP, CPP, PaCO2, and AVDO2 were unchanged. ICP decreased from 16 +/- 1 mm Hg to 14 +/- 1 mm Hg (mean +/- SE; P < 0.001) and VMCA decreased from 44 +/- 4 cm/s to 39 +/- 4 cm/s (P < 0.001). Total EEG power decreased (P < 0.02). These results suggest that ketamine can be used in anesthetized, mechanically ventilated patients with mildly increased ICP without adversely altering cerebral hemodynamics.
authors.affiliation: Department of Anesthesiology, University of Washington School of Medicine, Seattle, USA.
authors.forename: T S
authors.initials: TS
authors.lastname: Mayberg
authors.forename: A M
authors.initials: AM
authors.lastname: Lam
authors.forename: B F
authors.initials: BF
authors.lastname: Matta
authors.forename: K B
authors.initials: KB
authors.lastname: Domino
authors.forename: H R
authors.initials: HR
authors.lastname: Winn
mesh_terms: D000769:Anesthesia, Inhalation; D001783:Blood Flow Velocity / Q000187:drug effects; D001794:Blood Pressure / Q000187:drug effects; D001932:Brain Neoplasms / Q000601:surgery; D002245:Carbon Dioxide / Q000097:blood; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000187:drug effects; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D003399:Craniotomy; D004569:Electroencephalography / Q000187:drug effects; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D002532:Intracranial Aneurysm / Q000601:surgery; D007427:Intracranial Pressure / Q000187:drug effects*; D007530:Isoflurane / Q000008:administration & dosage* / Q000494:pharmacology; D007649:Ketamine / Q000494:pharmacology*; D008875:Middle Aged; D009609:Nitrous Oxide / Q000008:administration & dosage* / Q000494:pharmacology; D010100:Oxygen / Q000097:blood; D017585:Ultrasonography, Doppler, Transcranial
chemical_list: D002245:Carbon Dioxide; D007649:Ketamine; D007530:Isoflurane; D009609:Nitrous Oxide; D010100:Oxygen