Specific expression of G-dystrophin (Dp71) in the brain.
Duchenne muscular dystrophy is associated with mental retardation and several dystrophin transcripts are differentially expressed in specific brain areas. G-dystrophin (Dp71) is known to be the predominant isoform in the brain. We have localized its mRNA to be present predominantly in the dentate gyrus and in the olfactory bulb. This distribution is specific and significantly different from that for the full-size dystrophin transcripts, present mainly in CA regions of the hippocampus, in the cerebral cortex and in cerebellar Purkinje cells. Furthermore, our data show that the various dystrophins co-localize with the dystroglycan in the brain.
Górecki
D C
DC
Molecular Neurobiology Unit, Royal Free Hospital School of Medicine, London, UK.
Barnard
E A
EA
D000818:Animals; D001345:Autoradiography; D001483:Base Sequence; D001923:Brain Chemistry / Q000502:physiology*; D016189:Dystrophin / Q000031:analogs & derivatives* / Q000096:biosynthesis; D006624:Hippocampus / Q000378:metabolism; D017403:In Situ Hybridization; D007536:Isomerism; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009137:Muscular Dystrophy, Animal / Q000378:metabolism*; D009830:Olfactory Bulb / Q000378:metabolism; D015345:Oligonucleotide Probes; D051381:Rats
D016189:Dystrophin; D015345:Oligonucleotide Probes; C085339:apo-dystrophin 1