title: Pravastatin-associated myopathy. Report of a case.
abstract: A case of acute inflammatory myopathy associated with the use of pravastatin, a new hydrophilic 3-hydroxy-3 methylglutaril coenzyme A reductase inhibitor, is reported. The patient, a 69-year-old man was affected by non-insulin-dependent diabetes mellitus and hypertension. He assumed pravastatin (20 mg/day) because of hypercholesterolemia. He was admitted with acute myopathy of the lower limbs which resolved in a few days after pravastatin discontinuation. A previously unknown hypothyroidism, probably due to chronic autoimmune thyroiditis, was evidenced. Muscle biopsy (left gastrocnemius) revealed a perimysial and endomysial inflammatory infiltrate with a prevalence of CD4+ lymphocytes. While lovastatin and simvastatin have been associated with toxic myopathy, pravastatin-associated myopathy could represent a distinct, inflammatory entity.
authors.affiliation: Istituto di Clinica Medica, Università, Brescia.
authors.forename: T
authors.initials: T
authors.lastname: Scalvini
authors.forename: D
authors.initials: D
authors.lastname: Marocolo
authors.forename: B
authors.initials: B
authors.lastname: Cerudelli
authors.forename: I
authors.initials: I
authors.lastname: Sleiman
authors.forename: G P
authors.initials: GP
authors.lastname: Balestrieri
authors.forename: G
authors.initials: G
authors.lastname: Giustina
mesh_terms: D000208:Acute Disease; D000368:Aged; D001706:Biopsy; D003924:Diabetes Mellitus, Type 2 / Q000150:complications*; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications / Q000188:drug therapy*; D006973:Hypertension / Q000150:complications; D008297:Male; D018482:Muscle, Skeletal / Q000187:drug effects / Q000473:pathology; D009135:Muscular Diseases / Q000139:chemically induced*; D009220:Myositis / Q000139:chemically induced*; D017035:Pravastatin / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D017035:Pravastatin