False-positive antineutrophil cytoplasmic antibody in aspergillosis with oxalosis.
Although highly specific for Wegener's granulomatosis and other vasculitides, false-positive antineutrophil cytoplasmic antibody is occasionally encountered in other nonvasculitic conditions. We report a case of clinically suspected Wegener's granulomatosis with a large pulmonary cavity, renal failure, and positive cytoplasmic antineutrophil cytoplasmic antibody reaction. The patient died before initiation of immunosuppressive therapy. Postmortem examination revealed pulmonary aspergillosis due to Aspergillus niger, with extensive pulmonary and renal oxalosis, which lead to renal failure. The possible role of oxalosis in the pathogenesis of false-positive antineutrophil cytoplasmic antibody reaction is discussed.
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Department of Pathology, VA Medical Center, State University of New York-Health Science Center, Syracuse 13210, USA.
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D019268:Antibodies, Antineutrophil Cytoplasmic; D001228:Aspergillosis / Q000473:pathology*; D001323:Autoantibodies / Q000032:analysis*; D002129:Calcium Oxalate / Q000032:analysis*; D005189:False Positive Reactions; D014890:Granulomatosis with Polyangiitis / Q000473:pathology; D006801:Humans; D007676:Kidney Failure, Chronic / Q000209:etiology*; D008168:Lung / Q000473:pathology; D008172:Lung Diseases, Fungal / Q000473:pathology*; D008297:Male; D008875:Middle Aged
D019268:Antibodies, Antineutrophil Cytoplasmic; D001323:Autoantibodies; D002129:Calcium Oxalate