title: Rifampicin inactivation by Bacillus species.
abstract: The ability of strains of Bacillus, Staphylococcus, Pseudomonas, and Escherichia coli to inactivate rifampicin was tested. Most Bacillus strains were found to inactivate rifampicin. Two modes of inactivation were identified; one was phosphorylation and the other involved decolorization. Presence or absence of either mechanism appeared unrelated to the phylogenetic relatedness of strains. None of the other organisms could inactivate this antibiotic.
authors.affiliation: Research Center for Pathogenic Fungi and Microbial Toxicoses, Chiba University, Japan.
authors.forename: E R
authors.initials: ER
authors.lastname: Dabbs
authors.forename: K
authors.initials: K
authors.lastname: Yazawa
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: Y
authors.initials: Y
authors.lastname: Mikami
authors.forename: M
authors.initials: M
authors.lastname: Miyaji
authors.forename: S J
authors.initials: SJ
authors.lastname: Andersen
authors.forename: N
authors.initials: N
authors.lastname: Morisaki
authors.forename: S
authors.initials: S
authors.lastname: Iwasaki
authors.forename: O
authors.initials: O
authors.lastname: Shida
authors.forename: H
authors.initials: H
authors.lastname: Takagi
mesh_terms: D001407:Bacillus / Q000187:drug effects* / Q000254:growth & development; D004352:Drug Resistance, Microbial; D008826:Microbial Sensitivity Tests; D010766:Phosphorylation; D010802:Phylogeny; D012293:Rifampin / Q000494:pharmacology*; D013045:Species Specificity; D013329:Structure-Activity Relationship
chemical_list: D012293:Rifampin