title: Idiopathic juvenile osteoporosis: five-year case follow-up.
abstract: Juvenile osteoporosis is a disease of childhood and adolescence exhibiting marked clinical variability in bone change. The disease usually begins in the prepubertal period or even younger. A case of a Chinese boy suffering from back pain and generalized osteoporosis since 9 yr of age who spontaneously recovered at 14 yr of age when entering puberty is reported. The affected patient was clinically normal (as shown by X rays), until he fractured his left humerus. Metabolic studies indicated a negative calcium balance, but serum calcium, phosphorus, alkaline phosphatase, parathyroid hormone, calcifediol, calcitriol, cortisol and sex hormones were normal. X ray showed typical generalized osteoporosis with vertebral collapse. The disease markedly improved within 5 yr. No family history of inherited skeletal disorders or presenile osteoporosis was noted. The diagnosis of idiopathic juvenile osteoporosis was made.
authors.affiliation: Department of Pediatrics, National Taiwan University Hospital, Taipei, ROC.
authors.forename: J W
authors.initials: JW
authors.lastname: Hou
authors.forename: T R
authors.initials: TR
authors.lastname: Wang
mesh_terms: D017668:Age of Onset; D002648:Child; D005598:Fractures, Spontaneous / Q000209:etiology; D005684:Gait; D006801:Humans; D017116:Low Back Pain / Q000209:etiology; D008297:Male; D010024:Osteoporosis / Q000150:complications / Q000000981:diagnostic imaging; D011859:Radiography; D012075:Remission, Spontaneous