Renal transplantation and osteoporosis.
A cross sectional study assessed the bone mineral density (BMD) of 20 young adult patients who received a renal transplantation in childhood. The BMD of the lumbar spine, mainly trabecular bone, and of the total body, mainly cortical bone, were measured and expressed as an SD score. Fourteen patients (70%) had a BMD SD score of the lumbar spine below -1, of whom six patients were below -2. Fifteen patients (75%) had a BMD SD score of the total body below -1, of whom seven patients were below -2, Both trabecular and cortical bone appeared to be involved in the osteopenic process. The cumulative dose of prednisone was inversely correlated to both lumbar spine and total body BMD SD score. In a multiple regression analysis the cumulative dose of prednisone appeared to be the only factor with a significant effect on BMD SD score. Most young adult patients who had received a renal transplantation in childhood had moderate to severe osteopenia. Corticosteroid treatment played a major part in the development of osteopenia in these patients.
Boot
A M
AM
Department of Paediatrics, Sophia Children's Hospital, Medical Schools of Erasmus University, Rotterdam, The Netherlands.
Nauta
J
J
Hokken-Koelega
A C
AC
Pols
H A
HA
de Ridder
M A
MA
de Muinck Keizer-Schrama
S M
SM
D000328:Adult; D015519:Bone Density / Q000187:drug effects; D003430:Cross-Sectional Studies; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D016030:Kidney Transplantation / Q000502:physiology*; D008159:Lumbar Vertebrae / Q000502:physiology; D008297:Male; D010024:Osteoporosis / Q000139:chemically induced / Q000209:etiology*; D011241:Prednisone / Q000009:adverse effects* / Q000494:pharmacology; D011627:Puberty / Q000502:physiology; D011628:Puberty, Delayed / Q000503:physiopathology; D012044:Regression Analysis
D011241:Prednisone