Omeprazole administration does not impair gastrointestinal mucosal perfusion, oxygenation, and hexosamine generation.
Omeprazole is a potent antisecretory drug that acts by inhibiting the gastric proton pump. In the present study, we have observed the effects of this drug on gastrointestinal mucosal perfusion, oxygenation, and hexosamine generation in humans. Sixteen healthy volunteers were included. Gastrointestinal mucosal perfusion and oxygenation (duodenum, antrum, and corpus) were assessed by laser-Doppler flowmetry and reflectance spectrophotometry. Biopsy specimens were also taken from each location to determine hexosamine content as a quantitative indicator of mucus generation. In addition, serum gastrin level was measured. After baseline data were obtained, subjects were randomly assigned to receive 20 mg of oral omeprazole once daily for 7 days (n = 8) or placebo (n = 8). All measurements were performed again after double-blinded drug administration. No effect was found after placebo administration. In contrast, omeprazole administration significantly increased serum gastrin level (p < .05), suggesting an inhibition of acid secretion. However, this drug did not alter either laser-Doppler signal or oxygen saturation at each location. In addition, no change in mucosal hexosamine content was observed at each location. We conclude that oral omeprazole, despite its well-established antisecretory effect, has no adverse effect on the mucosal defense in humans.
Iwao
T
T
Department of Medicine II, Kurume University School of Medicine, Japan.
Toyonaga
A
A
Shigemori
H
H
Ikegami
M
M
Tanikawa
K
K
D000328:Adult; D004311:Double-Blind Method; D004386:Duodenum / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D005260:Female; D005753:Gastric Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D005755:Gastrins / Q000097:blood; D006595:Hexosamines / Q000096:biosynthesis*; D006801:Humans; D007413:Intestinal Mucosa / Q000098:blood supply / Q000187:drug effects* / Q000378:metabolism; D017078:Laser-Doppler Flowmetry; D008297:Male; D009853:Omeprazole / Q000494:pharmacology*; D010100:Oxygen / Q000378:metabolism*; D011706:Pyloric Antrum / Q000098:blood supply / Q000187:drug effects / Q000378:metabolism; D013053:Spectrophotometry
D005755:Gastrins; D006595:Hexosamines; D009853:Omeprazole; D010100:Oxygen