The incapability of interleukin-4 to induce AP-1 activity in murine mast cells.
The results presented in this study shed new light on the molecular mechanism responsible for the control of interleukin (IL)-3- and IL-4 mediated mast cell proliferation. By measurements of AP-1 DNA-binding activity, it was found that IL-3 induced such activity while IL-4 did not. This difference in the pattern of AP-1 DNA-binding activity induced by each lymphokine indicates the differential involvement of AP-1 in the different proliferative responses of mast cells to IL-3 and IL-4.
Chaikin
E
E
Department Biochemistry, Hebrew University, Hadassah Medical School, Jerusalem, Israel.
Hakeem
I
I
Razin
E
E
D000470:Alkaloids / Q000494:pharmacology; D000818:Animals; D002460:Cell Line; D005786:Gene Expression Regulation / Q000187:drug effects*; D007377:Interleukin-3 / Q000494:pharmacology*; D015847:Interleukin-4 / Q000494:pharmacology*; D008407:Mast Cells / Q000187:drug effects*; D051379:Mice; D011493:Protein Kinase C / Q000037:antagonists & inhibitors / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis / Q000235:genetics; D016755:Proto-Oncogene Proteins c-jun / Q000096:biosynthesis / Q000235:genetics; D015398:Signal Transduction; D019311:Staurosporine; D018808:Transcription Factor AP-1 / Q000096:biosynthesis*
D000470:Alkaloids; D007377:Interleukin-3; D016760:Proto-Oncogene Proteins c-fos; D016755:Proto-Oncogene Proteins c-jun; D018808:Transcription Factor AP-1; D015847:Interleukin-4; D011493:Protein Kinase C; D019311:Staurosporine