Treatment of localized Mycobacterium avium complex infection with clofazimine and doxycycline in a cat.
Mycobacterium avium complex infection resulted in a granuloma that developed at the base of the left ear in a cat. The lesion caused vestibular dysfunction and facial palsy on the left side and protruded into the oral cavity on that side. The cat was treated successfully, with resolution of the lesion and elimination of the organism, by use of combined administration of clofazimine and doxycycline. Adverse effects of the clofazimine treatment included temporary reddish-orange discoloration of the cat's skin and mucous membranes.
Kaufman
A C
AC
Department of Small Animal Medicine and Surgery, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
Greene
C E
CE
Rakich
P M
PM
Weigner
D D
DD
D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy*; D002415:Cats; D002991:Clofazimine / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D004318:Doxycycline / Q000494:pharmacology / Q000627:therapeutic use*; D006099:Granuloma / Q000188:drug therapy / Q000382:microbiology / Q000601:surgery / Q000662:veterinary; D007917:Leprostatic Agents / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D009162:Mycobacterium avium / Q000187:drug effects / Q000302:isolation & purification; D010859:Pigmentation Disorders / Q000139:chemically induced / Q000662:veterinary; D014376:Tuberculosis / Q000188:drug therapy / Q000662:veterinary*
D000900:Anti-Bacterial Agents; D007917:Leprostatic Agents; D002991:Clofazimine; D004318:Doxycycline