Epstein-Barr virus lymphoproliferative disease of donor origin after kidney transplantation: a case report.
A case of an Epstein-Barr virus (EBV)-associated B lymphoproliferative disorder presented as a renal transplant obstruction is reported. The diagnosis was made from histology, immunohistochemistry, and EBV expression studies. Cytogenetic analysis showed the tumor to be of donor origin and revealed chromosomal translocation 46, XY, inv (1)(p35; q41), involving the EBV insertion site 1(1p35) and transforming growth factor beta 2(1q41) loci.
Renoult
E
E
Division of Nephrology, Hôpital de Brabois, University of Nancy, France.
Aymard
B
B
Grégoire
M J
MJ
Bellou
A
A
Hubert
J
J
Hestin
D
D
Audouin
J
J
Lederlin
P
P
Kessler
M
M
D000368:Aged; D001402:B-Lymphocytes; D007446:Chromosome Inversion; D002878:Chromosomes, Human, Pair 1; D004251:DNA Transposable Elements / Q000235:genetics; D004279:DNA, Viral / Q000235:genetics; D005260:Female; D006566:Herpesviridae Infections / Q000235:genetics / Q000635:transmission* / Q000821:virology; D004854:Herpesvirus 4, Human / Q000235:genetics; D006801:Humans; D016030:Kidney Transplantation / Q000009:adverse effects*; D008232:Lymphoproliferative Disorders / Q000209:etiology* / Q000235:genetics / Q000821:virology; D014019:Tissue Donors; D016212:Transforming Growth Factor beta / Q000235:genetics; D014412:Tumor Virus Infections / Q000235:genetics / Q000635:transmission* / Q000821:virology
D004251:DNA Transposable Elements; D004279:DNA, Viral; D016212:Transforming Growth Factor beta