Development of electroretinographic alterations in streptozotocin-induced diabetes in rats.
Development of electroretinographic alterations in 9-week-old experimental diabetic rats was studied for up to 6 weeks after a single intraperitoneal injection of streptozotocin (STZ, 60 mg/kg). The amplitudes and the peak latencies of the a and b waves in the diabetic rats did not differ significantly from those in the control rats. In contrast, the diabetic rats showed a significantly smaller amplitude of the second oscillatory potential (OP) 6 weeks after STZ treatment, and furthermore significantly delayed OP peaks as early as 2-3 weeks after STZ treatment. Vitreous fluorophotometric abnormality developed 6 weeks after STZ treatment. None of the diabetic rats had fundus angiographic changes. These results suggest that hyperglycemia or its related changes rapidly affects the light-induced electrical activities of the retina.
Sakai
H
H
Developmental Research Laboratories, Santen Pharmaceutical Co. Ltd., Osaka, Japan.
Tani
Y
Y
Shirasawa
E
E
Shirao
Y
Y
Kawasaki
K
K
D000818:Animals; D001786:Blood Glucose; D001835:Body Weight; D003921:Diabetes Mellitus, Experimental / Q000503:physiopathology*; D003930:Diabetic Retinopathy / Q000503:physiopathology*; D004596:Electroretinography; D005128:Eye Diseases / Q000473:pathology; D015590:Fluorophotometry; D008297:Male; D051381:Rats; D011914:Rats, Inbred BN; D012160:Retina / Q000503:physiopathology*; D013311:Streptozocin; D014822:Vitreous Body / Q000473:pathology
D001786:Blood Glucose; D013311:Streptozocin