title: [Low-dose consecutive intra-arterial infusion of CDDP to treat advanced cervical carcinoma: usefulness of a vascular access device with alteration of intrapelvic blood flow].
abstract: Percutaneous transarterial implantation of a vascular access device (VAD) was used to treat advanced cervical carcinoma in 12 patients (IIb 3, IIIb 5, IVa 4). After altering intrapelvic flow by embolization under pelvic angiography, a 5 F catheter was placed in the internal iliac artery on the side of tumor dominance. RI angiography with 99mTc-MAA via the VAD showed 99% higher accumulation in the anterior division than in the posterior division of the pelvis. Consecutive infusion of cisplatin, 12.5 mg/body, via the VAD showed less toxicity than systemic chemotherapy. Overall response rate was 75% (CR 4, PR 5, NC 3). Curative surgical treatment was successful in nine of these 12 patients. This technique was evaluated to be effective for treatment of advanced cervical carcinoma.
authors.affiliation: Department of Radiology, Jikei University, School of Medicine.
authors.forename: F
authors.initials: F
authors.lastname: Ohsugi
authors.forename: T
authors.initials: T
authors.lastname: Yamada
authors.forename: S
authors.initials: S
authors.lastname: Tada
mesh_terms: D000328:Adult; D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000188:drug therapy* / Q000503:physiopathology; D002406:Catheterization, Peripheral; D002408:Catheters, Indwelling; D002945:Cisplatin / Q000008:administration & dosage*; D005260:Female; D006801:Humans; D015918:Infusion Pumps, Implantable; D007261:Infusions, Intra-Arterial; D008875:Middle Aged; D010388:Pelvis / Q000098:blood supply*; D012039:Regional Blood Flow; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D002945:Cisplatin