title: Qualitative features of the memory deficit associated with HIV infection and AIDS: cross-validation of a discriminant function classification scheme.
abstract: The neuropsychological defects associated with late stage HIV infection and AIDS have been characterized as being similar to those seen in patients with dementia syndromes of subcortical etiologies. The purpose of this paper is to report on the cross-center replication of the classification of HIV-infected subjects' neuropsychological status based on a discriminant function generated from other HIV-related and unrelated cognitively impaired subjects. Of the HIV-control subjects, 42/46 (91.3%) were classified as "Normal", with only two subjects in each of two "dementia" groups: subcortical and cortical. However, similar to other HIV+ samples, a large proportion (36%) of our HIV-infected subjects were classified as "Subcortical", with 61% classified as "Normal", and one (3%) in the "Cortical" group. These data demonstrate that not only does the cognitive performance of some HIV+ subjects have distinct features relative to that of HIV-control subjects, but that the features are consistent with previous suggestions that such patients have a "Subcortical" pattern of impairment.
authors.affiliation: Department of Psychiatry, University of Pittsburgh School of Medicine, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Becker
authors.forename: R
authors.initials: R
authors.lastname: Caldararo
authors.forename: O L
authors.initials: OL
authors.lastname: Lopez
authors.forename: M A
authors.initials: MA
authors.lastname: Dew
authors.forename: S K
authors.initials: SK
authors.lastname: Dorst
authors.forename: G
authors.initials: G
authors.lastname: Banks
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000523:psychology*; D000328:Adult; D004192:Discrimination, Psychological; D006678:HIV; D006801:Humans; D007858:Learning; D008297:Male; D008569:Memory Disorders / Q000523:psychology*; D011939:Mental Recall; D008875:Middle Aged; D009483:Neuropsychological Tests; D011569:Psychiatric Status Rating Scales