title: Transcutaneous blood glucose monitoring system based on an ISFET glucose sensor and studies on diabetic patients.
abstract: A transcutaneous blood glucose monitoring system consists of an ion-sensitive field-effect transistor (ISFET) glucose sensor unit and a suction effusion fluid (SEF) collecting unit. The SEF is directly collected by a weak suction (400 mmHg absolute pressure) through the skin from which the corneum layer of the epidermis has been previously removed. An ISFET glucose sensor unit is able to measure glucose concentrations in a microliter order sampling volume. The system was applied to three diabetic patients during a 75 g oral glucose tolerance test for monitoring blood glucose levels. During the experiments, glucose changes in the SEF followed actual blood glucose levels with 10 min delays. Results suggest the feasibility of utilizing quasi-continuous, transcutaneous blood glucose monitoring for individual patients with various diabetic histories or diabetic complications.
authors.affiliation: Central Research Laboratories, NEC Corporation, Kanagawa, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Ito
authors.forename: A
authors.initials: A
authors.lastname: Saito
authors.forename: S
authors.initials: S
authors.lastname: Kayashima
authors.forename: J
authors.initials: J
authors.lastname: Kimura
authors.forename: T
authors.initials: T
authors.lastname: Kuriyama
authors.forename: N
authors.initials: N
authors.lastname: Nagata
authors.forename: T
authors.initials: T
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Kikuchi
mesh_terms: D000368:Aged; D000818:Animals; D015374:Biosensing Techniques; D001786:Blood Glucose / Q000032:analysis*; D001826:Body Fluids; D002417:Cattle; D003920:Diabetes Mellitus / Q000097:blood*; D005260:Female; D006801:Humans; D007477:Ions; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic / Q000295:instrumentation* / Q000379:methods*; D013396:Suction
chemical_list: D001786:Blood Glucose; D007477:Ions