Azithromycin levels in cervical mucus and plasma after a single 1.0g oral dose for chlamydial cervicitis.
OBJECTIVE
To determine the kinetics of azithromycin in cervical mucus and plasma.


METHODS
Azithromycin concentrations were determined in plasma and mucus samples from 20 women with cervical chlamydial infection one, seven and fourteen days after a single oral 1.0 g dose.


RESULTS
In mucus, all measurable azithromycin concentrations were above the minimal inhibitory concentration against Chlamydia trachomatis on day 7 as well as on day 14.


CONCLUSIONS
The high cervical mucus concentrations of azithromycin can explain the high clinical and microbiological efficacy.
Worm
A M
AM
Department of Dermato-Venereology, Bispebjerg Hospital, Copenhagen NV, Denmark.
Osterlind
A
A
D000284:Administration, Oral; D000900:Anti-Bacterial Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D017963:Azithromycin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D002582:Cervix Mucus / Q000378:metabolism*; D005260:Female; D006801:Humans; D016896:Treatment Outcome; D002575:Uterine Cervicitis / Q000188:drug therapy / Q000378:metabolism*
D000900:Anti-Bacterial Agents; D017963:Azithromycin