Control of inflammatory processes by cell-impermeable inhibitors of phospholipase A2.
Cell-impermeable inhibitors of phospholipase A2 were prepared by linking inhibiting molecules to macromolecular carriers which prevent the inhibitor's internalization. These preparations inhibit the release of oxygen reactive species from neutrophils and cell death induced by inflammatory agents, as well as bleomycin-induced lung injury.
Yedgar
S
S
Department of Biochemistry, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Dan
P
P
Dagan
A
A
Ginsburg
I
I
Lossos
I S
IS
Breuer
R
R
D000818:Animals; D002266:Carboxymethylcellulose Sodium / Q000737:chemistry*; D002463:Cell Membrane Permeability; D002478:Cells, Cultured; D006224:Cricetinae; D006801:Humans; D007249:Inflammation / Q000139:chemically induced / Q000188:drug therapy*; D009504:Neutrophils / Q000187:drug effects / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000737:chemistry*; D010741:Phospholipases A / Q000037:antagonists & inhibitors*; D054467:Phospholipases A2; D017382:Reactive Oxygen Species / Q000378:metabolism*
D010714:Phosphatidylethanolamines; D017382:Reactive Oxygen Species; D010741:Phospholipases A; D054467:Phospholipases A2; D002266:Carboxymethylcellulose Sodium