The clinical and pathological spectrum of Steele-Richardson-Olszewski syndrome (progressive supranuclear palsy): a reappraisal.
Seventeen patients with a progressive bradykinetic syndrome and post-mortem findings of neurofibrillary degeneration in cerebral cortex, subcortical nuclei and brainstem were studied. Seven fulfilled currently accepted clinical diagnostic criteria for Steele-Richardson-Olszewski syndrome, whereas the remainder who lacked supranuclear gaze palsy had alternative clinical diagnoses (idiopathic Parkinson's disease, six cases; cerebrovascular disease, two cases; Parkinson's syndrome, one case; Alzheimer's disease, one case). The clinical and pathological findings of the two groups were compared in an attempt to better define the spectrum of Steele-Richardson-Olszewski disease.
Daniel
S E
SE
Parkinson's Disease Society Brain Tissue Bank, Institute of Neurology, London, UK.
de Bruin
V M
VM
Lees
A J
AJ
D017668:Age of Onset; D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis / Q000473:pathology; D001479:Basal Ganglia / Q000473:pathology*; D002561:Cerebrovascular Disorders; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016874:Neurofibrillary Tangles / Q000648:ultrastructure; D009886:Ophthalmoplegia / Q000473:pathology; D009929:Organ Size; D010300:Parkinson Disease / Q000175:diagnosis / Q000473:pathology; D010858:Pigmentation; D012189:Retrospective Studies; D013494:Supranuclear Palsy, Progressive / Q000175:diagnosis / Q000453:epidemiology / Q000473:pathology*; D016875:tau Proteins / Q000032:analysis
D016875:tau Proteins