Enhancement by TNF-alpha of reactivation and replication of latent herpes simplex virus from trigeminal ganglia of mice.
The influence of tumor-necrosis-factor-alpha (TNF-alpha), granulocyte-macrophage colony-stimulating factor (GM-CSF), interleukine-1 (IL-1) and IL-3 on the in vitro reactivation frequency and replication rate of trigeminal ganglia of mice latently infected with herpes simplex virus (HSV) strain KOS was studied. It could be demonstrated that TNF-alpha and possibility GM-CSF, but not IL-1 and IL-3, enhanced the reactivation frequency and replication of HSV. Interferon alpha/beta (IFN alpha/beta) prevented reactivation and replication.
Walev
I
I
Division of Experimental Virology, Johannes-Gutenberg-University, Mainz, Federal Republic of Germany.
Podlech
J
J
Falke
D
D
D000818:Animals; D002522:Chlorocebus aethiops; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000494:pharmacology; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D016898:Interferon-alpha / Q000494:pharmacology; D016899:Interferon-beta / Q000494:pharmacology; D007375:Interleukin-1 / Q000494:pharmacology; D007377:Interleukin-3 / Q000494:pharmacology; D051379:Mice; D008807:Mice, Inbred BALB C; D012668:Trigeminal Ganglion / Q000821:virology*; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology*; D014709:Vero Cells; D014775:Virus Activation / Q000187:drug effects*; D017735:Virus Latency / Q000187:drug effects; D014779:Virus Replication
D016898:Interferon-alpha; D007375:Interleukin-1; D007377:Interleukin-3; D014409:Tumor Necrosis Factor-alpha; D016899:Interferon-beta; D016178:Granulocyte-Macrophage Colony-Stimulating Factor