title: Absence of TAP 2D in Yoruba Nigerians.
abstract: We have characterized TAP allele frequencies in a panel of 71 Yoruba Nigerians using ARMS-PCR. With the exception that TAP 2D was absent in Nigerians, TAP 2 allele frequencies in this population were found to be similar to those in a UK white population. HLA-DR4 also was found to be at a low frequency in Yoruba Nigerians (1.4%). This may reflect the absence of TAP 2D in Nigerians as DR4 and TAP 2D are in linkage disequilibrium in UK Caucasoids. The most frequent TAP 1 allele in Yoruba Nigerians was TAP 1A (49%). However, this value will be an underestimate as TAP1 alleles could not be unequivocally assigned in 41% of subjects using the ARMS-PCR methodology.
authors.affiliation: ARC Epidemiology Research Unit, University of Manchester, UK.
authors.forename: A A
authors.initials: AA
authors.lastname: Awomoyi
authors.forename: R P
authors.initials: RP
authors.lastname: Donn
authors.forename: E J
authors.initials: EJ
authors.lastname: Davies
authors.forename: D
authors.initials: D
authors.lastname: Carthy
authors.forename: W
authors.initials: W
authors.lastname: Thomson
authors.forename: W E
authors.initials: WE
authors.lastname: Ollier
mesh_terms: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters / Q000235:genetics*; D000328:Adult; D000483:Alleles; D044383:Black People / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D005787:Gene Frequency; D015804:HLA-DR4 Antigen / Q000235:genetics; D006801:Humans; D015810:Linkage Disequilibrium; D009549:Nigeria; D016133:Polymerase Chain Reaction; D006113:United Kingdom; D044465:White People / Q000235:genetics
chemical_list: D000071450:ATP Binding Cassette Transporter, Subfamily B, Member 3; D018528:ATP-Binding Cassette Transporters; D015804:HLA-DR4 Antigen; C071692:TAP2 protein, human