title: Age-related changes in the susceptibility to clofibric acid, a hypolipidemic agent, of male rat liver.
abstract: Age-related changes in the susceptibility to clofibric acid were investigated in male F344 rats of 8, 52, and 117 weeks old. Hepatomegaly, decrease of serum total cholesterol and triglyceride, increase of the total cytochrome P-450 contents, induction of the activities of microsomal omega-hydroxylation and peroxisomal beta-oxidation, proliferation of smooth endoplasmic reticulum and peroxisomes were detected in 8- and 52-week-old rats. In 117-week-old rats clofibric acid treatment resulted in decrease of serum total cholesterol, elevation of the activities of microsomal and peroxisomal enzymes, and slight proliferation of peroxisomes. These results suggest that the susceptibility of the male F344 rat liver to clofibric acid decreases in 117-week-old rats, though the effect is still recognizable.
authors.affiliation: Laboratory Animal Science, Sankyo Co. Ltd., Shizuoka, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Ohashi
authors.forename: M
authors.initials: M
authors.lastname: Teranishi
authors.forename: M
authors.initials: M
authors.lastname: Takaoka
authors.forename: S
authors.initials: S
authors.lastname: Manabe
authors.forename: N
authors.initials: N
authors.lastname: Matsunuma
authors.forename: T
authors.initials: T
authors.lastname: Makita
mesh_terms: D000284:Administration, Oral; D000375:Aging / Q000378:metabolism*; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002784:Cholesterol / Q000097:blood; D002995:Clofibric Acid / Q000633:toxicity*; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism; D006529:Hepatomegaly / Q000139:chemically induced; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008830:Microbodies / Q000187:drug effects / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D011916:Rats, Inbred F344
chemical_list: D002995:Clofibric Acid; D003577:Cytochrome P-450 Enzyme System; D002784:Cholesterol