title: Common virulence factors for bacterial pathogenicity in plants and animals.
abstract: A Pseudomonas aeruginosa strain (UCBPP-PA14) is infectious both in an Arabidopsis thaliana leaf infiltration model and in a mouse full-thickness skin burn model. UCBPP-PA14 exhibits ecotype specificity for Arabidopsis, causing a range of symptoms from none to severe in four different ecotypes. In the mouse model, UCBPP-PA14 is as lethal as other well-studied P. aeruginosa strains. Mutations in the UCBPP-PA14 toxA, plcS, and gacA genes resulted in a significant reduction in pathogenicity in both hosts, indicating that these genes encode virulence factors required for the full expression of pathogenicity in both plants and animals.
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, MA 02114, USA.
authors.forename: L G
authors.initials: LG
authors.lastname: Rahme
authors.forename: E J
authors.initials: EJ
authors.lastname: Stevens
authors.forename: S F
authors.initials: SF
authors.lastname: Wolfort
authors.forename: J
authors.initials: J
authors.lastname: Shao
authors.forename: R G
authors.initials: RG
authors.lastname: Tompkins
authors.forename: F M
authors.initials: FM
authors.lastname: Ausubel
mesh_terms: D036002:ADP Ribose Transferases; D000818:Animals; D017360:Arabidopsis / Q000382:microbiology*; D001426:Bacterial Proteins / Q000235:genetics; D001427:Bacterial Toxins; D001483:Base Sequence; D002056:Burns / Q000150:complications; D005098:Exotoxins / Q000235:genetics; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D009154:Mutation; D010740:Phospholipases / Q000235:genetics; D010935:Plant Diseases / Q000382:microbiology*; D011552:Pseudomonas Infections / Q000382:microbiology*; D011550:Pseudomonas aeruginosa / Q000235:genetics / Q000254:growth & development / Q000472:pathogenicity*; D014774:Virulence / Q000235:genetics; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A
chemical_list: D036002:ADP Ribose Transferases; D001426:Bacterial Proteins; D001427:Bacterial Toxins; D005098:Exotoxins; D010740:Phospholipases; D037521:Virulence Factors; D000097668:Pseudomonas aeruginosa Exotoxin A; C091100:GacA protein, Bacteria