Transmission of multidrug-resistant Mycobacterium tuberculosis among persons exposed in a medical examiner's office, New York.
OBJECTIVE
To determine the prevalence of and risk factors for having a positive tuberculin skin test (TST) result among employees at a medical examiner's office (MEO).


METHODS
Cohort study, environmental investigation.


METHODS
Several employees at a medical examiner's office were found to have positive TST results after autopsies were performed on persons with multidrug-resistant tuberculosis (MDR-TB).


METHODS
Employees of the MEO.


RESULTS
Of 18 MEO employees, 5 (28%) had a positive TST result; 2 of these 5 had TST conversions. We observed a trend between TST conversion and participation in autopsies on persons with MDR-TB (2 of 2 converters versus 3 of 13 employees with negative TST; relative risk = 4.3; 95% confidence interval 1.61 to 11.69; P = 0.10). The environmental investigation revealed that the autopsy room was at positive pressure relative to the rest of the MEO and that air from the autopsy room mixed throughout the facility.


CONCLUSIONS
A systematic approach to preventing transmission of Mycobacterium tuberculosis in autopsy suites should include effective environmental controls and routine tuberculin skin testing of employees.
Ussery
X T
XT
Division of Bacterial and Mycotic Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA.
Bierman
J A
JA
Valway
S E
SE
Seitz
T A
TA
DiFerdinando
G T
GT
Ostroff
S M
SM
D001344:Autopsy; D015331:Cohort Studies; D003334:Coroners and Medical Examiners; D006282:Health Personnel; D006801:Humans; D009518:New York; D009784:Occupational Diseases / Q000209:etiology*; D016273:Occupational Exposure; D011329:Prisoners; D012307:Risk Factors; D014374:Tuberculin Test; D018088:Tuberculosis, Multidrug-Resistant / Q000175:diagnosis / Q000635:transmission*