Reduced virulence of Candida albicans mutants affected in multidrug resistance.
Disruption of a multidrug resistance gene (CaMDR1) in Candida albicans resulted in mutant strains that colonized mouse kidneys to very high levels but were markedly reduced in their virulence. No obvious differences in several properties related to colonization and dissemination were noted among MDR+ or mdr- strains. These results suggest that specific fungal efflux pumps play a role in fungal pathogenicity.
Becker
J M
JM
Department of Microbiology, University of Tennessee, Knoxville 37996-0845, USA.
Henry
L K
LK
Jiang
W
W
Koltin
Y
Y
D018528:ATP-Binding Cassette Transporters / Q000502:physiology; D000818:Animals; D002176:Candida albicans / Q000235:genetics / Q000472:pathogenicity*; D002177:Candidiasis / Q000382:microbiology*; D018432:Drug Resistance, Multiple / Q000235:genetics*; D005800:Genes, Fungal; D007668:Kidney / Q000382:microbiology; D008297:Male; D051379:Mice; D016254:Mutagenesis, Insertional
D018528:ATP-Binding Cassette Transporters