Allopurinol reduces the severity of peritoneal adhesions in mice.
A study was designed to investigate the possibility of reducing peritoneal adhesion formation in mice by pretreatment with allopurinol. Allopurinol, at a dose of 35 mg/kg of body weight/d significantly reduced the severity of peritoneal adhesions (P < .001), and also the neutrophil response to ischemia (P < .05). Tissue myeloperoxidase activity at the site of ischemic injury was significantly lower in the allopurinol-treated mice at the end of 2 weeks (P < .001). However, xanthine oxidase was undetectable in both control and allopurinol-treated mice. These observations suggest that allopurinol reduces the severity of peritoneal adhesion formation in mice, possibly by reducing the neutrophil response to ischemia.
Rijhwani
A
A
Department of Pediatric Surgery, Christian Medical College Hospital, Vellore, Tamilnadu, India.
Sen
S
S
Gunasekaran
S
S
Ponnaiya
J
J
Balasubramanian
K A
KA
Mammen
K E
KE
D000493:Allopurinol / Q000008:administration & dosage / Q000627:therapeutic use*; D000818:Animals; D007813:Laparotomy; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D051379:Mice; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology; D010532:Peritoneal Diseases / Q000517:prevention & control*; D010537:Peritoneum / Q000201:enzymology; D009195:Peroxidase / Q000378:metabolism; D010865:Pilot Projects; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D015427:Reperfusion Injury / Q000517:prevention & control*; D000267:Tissue Adhesions / Q000517:prevention & control; D014969:Xanthine Oxidase / Q000378:metabolism
D008315:Malondialdehyde; D000493:Allopurinol; D009195:Peroxidase; D014969:Xanthine Oxidase