[Effect of 6-methyluracil on regulatory parameters of lipid peroxidation in thermal burn].
The effects of 6-methyluracil given in single intraperitoneal doses of 50 and 2.7 mg/kg on the healing of burn wounds and some physicochemical parameters of lipid peroxidation regulation were studied in the liver and erythrocytes of noninbred albino rats with thermal burns. 6-Methyluracil was shown to alter the time course of a wound process and to accelerate the healing of burn wounds. The drug doses under study were found to exert a great effect on the level of lipid antioxidative activity and the composition of phospholipids of the liver and erythrocytes, which remained for a long time after burn. The findings suggest the hypothesis that the capacity of 6-methyluracil to be involved in the regulation of lipid peroxidation processes underlies its therapeutic effect.
Taran
Iu P
IuP
Shishkina
L N
LN
Evseenko
L S
LS
Kukushkina
G V
GV
D000818:Animals; D002056:Burns / Q000188:drug therapy* / Q000378:metabolism; D005260:Female; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D051381:Rats; D014498:Uracil / Q000031:analogs & derivatives* / Q000494:pharmacology
D014498:Uracil; C008378:6-methyluracil