Pharmacokinetics and ventilatory effects of intravenous oxycodone in postoperative children.
1. Oxycodone hydrochloride (0.1 mg kg-1) was given by intravenous bolus to 18 children after ophthalmic surgery. Plasma was sampled for up to 8 h. Blood pressure, heart rate, peripheral arteriolar oxygen saturation, end-tidal carbon dioxide and halothane concentrations and ventilatory rate were also recorded. 2. Mean (+/- s.d.) values of drug clearance and volume of distribution (Vss) were 15.2 +/- 4.2 ml min-1 kg-1 and 2.1 +/- 0.8 l kg-1. Maximum mean end-tidal carbon dioxide concentration and minimum mean ventilatory rate occurred 8 min after administration of oxycodone but the minimum mean peripheral arteriolar oxygen saturation occurred at 4 min. 3. Oxycodone (0.1 mg kg-1) appears to cause greater ventilatory depression than comparable analgesic doses of other opioids.
Olkkola
K T
KT
Department of Anaesthesia, University of Helsinki, Finland.
Hamunen
K
K
Seppälä
T
T
Maunuksela
E L
EL
D002648:Child; D002675:Child, Preschool; D005260:Female; D006207:Half-Life; D006221:Halothane / Q000097:blood; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007275:Injections, Intravenous; D008657:Metabolic Clearance Rate; D013508:Ophthalmologic Surgical Procedures; D010098:Oxycodone / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D010149:Postoperative Pain / Q000188:drug therapy*; D012119:Respiration / Q000187:drug effects*; D013990:Tidal Volume
D010098:Oxycodone; D006221:Halothane