title: Treatment of HIV-associated Kaposi's sarcoma with paclitaxel.
abstract: We investigated whether paclitaxel was active in AIDS-associated Kaposi's sarcoma. We gave 135 mg/m2 intravenously over 3 hours every 21 days. Follow-up is available on the first 20 patients, most of whom had advanced Kaposi's sarcoma and severe immunocompromise. Neutropenia was the most frequent dose-limiting toxic effect; novel toxic effects included late fevers, rash, and eosinophilia. Creatinine increased in 2 patients and 1 patient had cardiomyopathy. There were 13 partial responses (65%, 95% CI 41-85%). All 5 patients with pulmonary involvement responded. Paclitaxel appears to be active against Kaposi's sarcoma as a single agent. Further studies, including a randomised trial, are warranted.
authors.affiliation: National Cancer Institute, Bethesda, MD 20892, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Saville
authors.forename: J
authors.initials: J
authors.lastname: Lietzau
authors.forename: J M
authors.initials: JM
authors.lastname: Pluda
authors.forename: I
authors.initials: I
authors.lastname: Feuerstein
authors.forename: J
authors.initials: J
authors.lastname: Odom
authors.forename: W H
authors.initials: WH
authors.lastname: Wilson
authors.forename: R W
authors.initials: RW
authors.lastname: Humphrey
authors.forename: E
authors.initials: E
authors.lastname: Feigal
authors.forename: S M
authors.initials: SM
authors.lastname: Steinberg
authors.forename: S
authors.initials: S
authors.lastname: Broder
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications; D000328:Adult; D002927:Cimetidine / Q000008:administration & dosage; D003907:Dexamethasone / Q000008:administration & dosage; D004155:Diphenhydramine / Q000008:administration & dosage; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000150:complications*; D015497:HIV-1; D006801:Humans; D008175:Lung Neoplasms / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D017239:Paclitaxel / Q000008:administration & dosage* / Q000009:adverse effects; D012514:Sarcoma, Kaposi / Q000188:drug therapy*
chemical_list: D003907:Dexamethasone; D002927:Cimetidine; D004155:Diphenhydramine; D017239:Paclitaxel