title: Perinatal mortality in lambs of ewes exposed to cultures of Diplodia maydis (= Stenocarpella maydis) during gestation. A study of the central-nervous-system lesions.
abstract: Previously published results of dosing trials, involving 82 ewes, revealed that 66% of the offspring of dams exposed to cultures of Diplodia maydis in the second trimester of pregnancy and 87% of lambs of ewes exposed in the third trimester, were born dead or died soon afterwards. Spongiform degeneration of myelin of varying degree was present in the brains of all the stillborn and non-viable lambs in these trials. Myelin lamellae were separated at the intraperiod line. The spongiform degeneration occurred throughout the central nervous system in severely affected animals, whereas in mildly affected lambs the lesions had a predilection for the white matter, particularly of the cerebellum and cerebrum. In 28 lambs the spongiform degeneration progressed to lytic necrosis, and hydrocephalus was recorded in two animals.
authors.affiliation: Onderstepoort Veterinary Institute, South Africa.
authors.forename: L
authors.initials: L
authors.lastname: Prozesky
authors.forename: T S
authors.initials: TS
authors.lastname: Kellerman
authors.forename: D P
authors.initials: DP
authors.lastname: Swart
authors.forename: B P
authors.initials: BP
authors.lastname: Maartens
authors.forename: R A
authors.initials: RA
authors.lastname: Schultz
mesh_terms: D000821:Animal Feed / Q000506:poisoning; D000818:Animals; D002490:Central Nervous System / Q000473:pathology; D002493:Central Nervous System Diseases / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D005260:Female; D005313:Fetal Death / Q000382:microbiology / Q000473:pathology / Q000662:veterinary*; D003904:Mitosporic Fungi / Q000502:physiology; D015651:Mycotoxicosis / Q000473:pathology / Q000662:veterinary*; D011247:Pregnancy; D011248:Pregnancy Complications; D012756:Sheep; D012757:Sheep Diseases / Q000382:microbiology / Q000473:pathology*; D003313:Zea mays / Q000382:microbiology