Hyperventilation in normal subjects. A clinical, gas-analytic and EMG study.
Clinical (paresthesiae and Trousseau's sign), EMG, blood biochemical (lactic acid and total Ca2+) and gas-analytic (pH, PCO2, PO2, HCO3) changes were studied during and after 5 min voluntary hyperventilation (HV) in 15 normal subjects. Paresthesiae and spontaneous motor activity were common manifestations (87% and 67% respectively) in our test. They were significantly related only to changes in pH, PCO2 and PO2, with paresthesiae arising earlier and at milder gas-analytic changes than motor activity. Paresthesiae and motor activity induced by HV cannot be used as reliable indicators of pathology. Their presence simply reflects the degree of the blood gas-analytic changes (pH, PCO2 and PO2) which therefore should be carefully monitored before drawing any conclusion from an HV test.
Montagna
P
P
Institute of Neurology, University of Bologna, Italy.
Paniccia
M
M
Marchello
L
L
Riva
R
R
D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001784:Blood Gas Analysis; D004576:Electromyography; D005260:Female; D006801:Humans; D006985:Hyperventilation / Q000097:blood / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D010292:Paresthesia / Q000097:blood / Q000503:physiopathology