Pattern of recovery from diaphragmatic fatigue over 24 hours.
The rate of recovery from diaphragmatic fatigue beyond 1 h is unknown. To investigate this question, we studied 12 healthy subjects and measured transdiaphragmatic twitch pressure (Pditw) using magnetic stimulation of the phrenic nerves. Measurements were obtained at baseline and after a fatigue protocol consisting of inspiratory resistive loading in which the subjects generated 60% of maximal transdiaphragmatic pressure until task failure. At baseline, Pditw was 38.9 +/- 1.1 (SE) cmH2O and fell to 25.1 +/- 0.6 cmH2O 10 min after the conclusion of the fatigue protocol (P < 0.01). Pditw increased to 27.6 +/- 0.9, 31.6 +/- 1.1, and 32.7 +/- 1.2 cmH2O 1, 8 and 24 h, respectively, after the conclusion of the fatigue protocol; the 24-h value was significantly lower than baseline (P < 0.01). The nadir in Pditw after the protocol was delayed by 10 min. In separate experiments, we showed that this delay was probably due to the development of twitch potentiation as a result of forceful diaphragmatic contractions during the fatigue protocol. In conclusion, induction of diaphragmatic fatigue with this experimental protocol produced a marked decrease in diaphragmatic contractility that persisted for at least 24 h.
Laghi
F
F
Division of Pulmonary and Critical Care Medicine, Edward Hines, Jr. Veterans Affairs Hospital, Hines, Illinois 60141, USA.
D'Alfonso
N
N
Tobin
M J
MJ
D000200:Action Potentials / Q000502:physiology; D000328:Adult; D003964:Diaphragm / Q000502:physiology*; D004558:Electric Stimulation; D004576:Electromyography; D005260:Female; D006801:Humans; D008297:Male; D009119:Muscle Contraction / Q000502:physiology; D018763:Muscle Fatigue / Q000502:physiology*; D010791:Phrenic Nerve / Q000502:physiology; D011312:Pressure