[Effect of cyclosporin monotherapy on proteinuria in a patient with membranoproliferative glomerulonephritis].
A-34-year-old man with a 16-year history of proteinuria was successfully treated with cyclosporin A (CsA). He was diagnosed as having membranoproliferative glomerulonephritis (MPGN) by renal needle biopsy and was treated with dipyridamole. In July 1992, he was readmitted for the treatment of anasarka. Although conventional predonisolone was administered for 5 months after one cycle of methyl-predonisolone pulse therapy, his nephrotic state did not improve. Immediately after the cessation of this treatment, he was given CsA 3 mg/kg/day. A marked reduction in proteinuria and edema occurred during the use of CsA for 6 months, with a reduction in the fractional excretion of protein. The nephrotic condition of this patient was subsequently stable without massive proteinuria despite the discontinuation of CsA at least for several months. These findings suggest that CsA monotherapy may be useful in patients with MPGN and steroid-resistant nephrotic syndrome.
Matsumoto
H
H
Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Shibasaki
T
T
Ohno
I
I
Sakai
O
O
Kuriyama
S
S
Tomonari
H
H
Utsunomiya
Y
Y
Nakao
T
T
D000328:Adult; D016572:Cyclosporine / Q000008:administration & dosage*; D015432:Glomerulonephritis, Membranoproliferative / Q000150:complications / Q000188:drug therapy*; D006801:Humans; D008297:Male; D011507:Proteinuria / Q000188:drug therapy*
D016572:Cyclosporine