5-HT2A serotonin receptors in the brain of rats and mice hereditarily predisposed to catalepsy.
Specific binding of [3H]ketanserin to 5-HT2A serotonin receptor sites in the corpus striatum and frontal cortex and the effect of 5-HT2A antagonists in rats and mice hereditarily predisposed to catalepsy has been studied. Cyproheptadine inhibited the expression of inherited catalepsy in rats and mice, whereas more selective 5-HT2A antagonists, ritanserin and ketanserin, failed to affect the catalepsy. A decrease in [3H]ketanserin-specific binding site density in the striatum of cataleptic animals compared to their noncataleptic counterparts was found. It was suggested that the decrease in the density of 5-HT2A receptor binding sites in the striatum represents a result of their downregulation due to increased serotonergic neurotransmission in the striatum of cataleptic animals.
Kulikov
A V
AV
Institute of Cytology & Genetics, Russian Academy of Sciences, Siberian Branch, Novosibirsk.
Avgustinovich
D F
DF
Kolpakov
V G
VG
Maslova
G B
GB
Popova
N K
NK
D000818:Animals; D002375:Catalepsy / Q000235:genetics / Q000378:metabolism*; D003342:Corpus Striatum / Q000378:metabolism*; D004198:Disease Susceptibility; D005069:Evaluation Studies as Topic; D005625:Frontal Lobe / Q000378:metabolism*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D011869:Radioligand Assay; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000378:metabolism; D012702:Serotonin Antagonists / Q000494:pharmacology*
D011985:Receptors, Serotonin; D012702:Serotonin Antagonists