title: Anticonflict effects of acute and chronic treatments with buspirone and gepirone in rats.
abstract: The anticonflict activities of buspirone and gepirone were examined in the Vogel's water licking test in rats. Acute treatment with buspirone induced a significant increase in water licking response, but gepirone showed slightly more marked effect than buspirone. The anticonflict activities of these compounds were potentiated by chronic administration. Especially, gepirone exhibited a dramatically remarkable anticonflict effect. These results suggest that gepirone has a great possibility of promising drug for anxiety.
authors.affiliation: Department of Hospital Pharmacy, Okayama University Medical School, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yamashita
authors.forename: R
authors.initials: R
authors.lastname: Oishi
authors.forename: Y
authors.initials: Y
authors.lastname: Gomita
mesh_terms: D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D002065:Buspirone / Q000494:pharmacology*; D003220:Conflict, Psychological; D008297:Male; D011743:Pyrimidines / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D017366:Serotonin Receptor Agonists / Q000494:pharmacology*; D013997:Time Factors
chemical_list: D014151:Anti-Anxiety Agents; D011743:Pyrimidines; D017366:Serotonin Receptor Agonists; C039979:gepirone; D002065:Buspirone