Stability of a 1 beta-methylcarbapenem antibiotic, meropenem (SM-7338) in aqueous solution.
The stability and the degradation products of 1 beta-methylcarbapenem, meropenem in aqueous solution were investigated. In pH 4-8 dilute solution, pseudo-first-order degradation was observed, and good stability of meropenem in aqueous solution was demonstrated by the effect of 1 beta-methyl group against hydrolysis of beta-lactam ring. As degradation products, the beta-lactam hydrolyzed product and the dimer product resulting from intermolecular aminolysis of beta-lactam ring by the amine of the second molecule were described.
Takeuchi
Y
Y
Research Center Sumitomo Pharmaceuticals Co., Ltd., Osaka, Japan.
Sunagawa
M
M
Isobe
Y
Y
Hamazume
Y
Y
Noguchi
T
T
D000890:Anti-Infective Agents / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D004355:Drug Stability; D007700:Kinetics; D000077731:Meropenem; D012996:Solutions; D013845:Thienamycins / Q000737:chemistry*; D014867:Water
D000890:Anti-Infective Agents; D012996:Solutions; D013845:Thienamycins; D014867:Water; D000077731:Meropenem