New secosteroids from an undescribed gorgonian of the genus Muricella.
Three new 9,10-secosteroids, calicoferols C-E [2-4] have been isolated from an undescribed gorgonian of the genus Muricella, and their structures determined by a combination of spectroscopic methods. Calicoferol D [3] exhibited potent antiviral activity and brine-shrimp lethality.
Seo
Y
Y
Marine Natural Products Chemistry Laboratory, Korea Ocean Research and Development Institute, Seoul.
Shin
J
J
Song
J I
JI
D000818:Animals; D000998:Antiviral Agents / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D001156:Artemia; D003063:Cnidaria / Q000737:chemistry*; D007928:Lethal Dose 50; D009682:Magnetic Resonance Spectroscopy; D017955:Poliovirus / Q000187:drug effects; D012632:Secosteroids / Q000302:isolation & purification* / Q000494:pharmacology / Q000633:toxicity; D018139:Simplexvirus / Q000187:drug effects
D000998:Antiviral Agents; D012632:Secosteroids; C096518:calicoferol C; C096519:calicoferol D; C096520:calicoferol E