[Familial occurrence of von Hippel-Lindau disease--a case report].
It is well known that von Hippel-Lindau disease is defined as the association of retinal angiomatosis and cerebellar hemangioblastomas. This disease is frequently associated with extra-neural vascular neoplasma, especially visceral angiomatous tumors. In this paper we report the familial occurrence of von Hippel-Lindau disease in a 55-year-old mother and her 24-year-old son. The mother had simultaneous multiple angiomas of the liver, stomach and head of the pancreas. The initial symptom was sudden onset of vertigo, possibly caused by a slow-growing cystic cerebellar lesion. An apparent genetic factor indicates that clinical settings begin in the early life of the patients.
Ichihashi
T
T
Department of Neurosurgery, Fukuroi Municipal Hospital, Sizuoka, Japan.
Harano
H
H
Mizuno
J
J
Kasahara
R
R
Hoshino
D
D
Nakagawa
H
H
D000328:Adult; D002528:Cerebellar Neoplasms / Q000235:genetics / Q000473:pathology; D005192:Family Health; D005260:Female; D018325:Hemangioblastoma / Q000235:genetics / Q000473:pathology; D006801:Humans; D008107:Liver Diseases / Q000235:genetics / Q000473:pathology; D008297:Male; D008875:Middle Aged; D010182:Pancreatic Diseases / Q000235:genetics / Q000473:pathology; D012164:Retinal Diseases / Q000235:genetics / Q000473:pathology; D013272:Stomach Diseases / Q000235:genetics / Q000473:pathology; D006623:von Hippel-Lindau Disease / Q000235:genetics* / Q000473:pathology