Aetiology of age-associated aneuploidy: a mechanism based on the 'free radical theory of ageing'.
A general model is put forward to explain the mechanism by which age-associated aneuploidies are produced. This is based on the free radical theory of ageing, which assumes a rise in oxidative stress with age. It is proposed that determination of indicators of oxidative stress in oocytes from various sources could be a first step in the testing of this hypothesis.
Tarín
J J
JJ
Department of Paediatrics, Obstetrics, and Gynaecology, Faculty of Medicine, University of Valencia, Spain.
D000375:Aging / Q000235:genetics*; D000782:Aneuploidy; D000818:Animals; D005260:Female; D005609:Free Radicals; D006801:Humans; D009865:Oocytes / Q000502:physiology; D018384:Oxidative Stress / Q000235:genetics*
D005609:Free Radicals