Flavonoids alter bone-remodelling in auditory ossicle organ cultures.
The beneficial role of bioflavonoids in an otosclerosis-like bone-remodelling process can be implicated from its interference with bone resorption induced by prostaglandin E2 (PGE2) in cultured guinea pig ossicles. Ipriflavone (7-isopropoxy-isoflavon) and quercetin reduced PGE2-elevated collagenase-like peptidase (Cl-peptidase) activity and potentiated a PGE2-induced decrease in collagen synthesis. The fact that PGE2 effects are mediated through cyclic AMP in bone turnover and flavonoids act synergistically with PGE2 in collagen synthesis confirm a cyclic AMP phosphodiesterase inhibitory role of flavonoids. It has already been attempted to use Ipriflavone medical treatment of otosclerosis. Quercetin, which has a better than Ipriflavone water-solubility seems as promising as Ipriflavone in the control of the otosclerotic bone-remodelling disturbance.
Sziklai
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I
ORL Clinic, Semmelweis Medical University Budapest, Hungary.
Ribári
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O
D000818:Animals; D001862:Bone Resorption / Q000378:metabolism*; D003094:Collagen / Q000096:biosynthesis; D046508:Culture Techniques; D015232:Dinoprostone / Q000494:pharmacology*; D005419:Flavonoids; D006168:Guinea Pigs; D007529:Isoflavones / Q000494:pharmacology*; D008297:Male; D010040:Otosclerosis / Q000473:pathology; D011348:Procollagen N-Endopeptidase / Q000378:metabolism; D011794:Quercetin / Q000494:pharmacology*; D013199:Stapes / Q000187:drug effects*
D005419:Flavonoids; D007529:Isoflavones; C018986:ipriflavone; D003094:Collagen; D011794:Quercetin; D011348:Procollagen N-Endopeptidase; D015232:Dinoprostone