Apoptosis: the in vivo mechanism which mediates spontaneous AK-5 tumor regression.
We have studied the mechanism of induction of apoptosis in a rat histiocytoma in vivo. Tumor cells are killed by necrosis and apoptosis when injected into immune animals; however, naive animals are incapable of killing the tumor cells. Tumor cells show DNA fragmentation within 3 h after transplantation in the peritoneal cavity. Natural killer (NK) cells act as the effector in causing tumor cell death through apoptosis since animals depleted of their NK cell population did not show target cell DNA fragmentation. Herbimycin A inhibits the induction of apoptosis, suggesting the requirement for protein phosphorylation.
Khar
A
A
Centre for Cellular and Molecular Biology, Hyderabad, India.
Pardhasaradhi
B V
BV
Varalakshmi
C
C
Ali
A M
AM
Manogaran
P S
PS
D000818:Animals; D017209:Apoptosis / Q000276:immunology*; D001201:Ascites / Q000276:immunology; D018219:Histiocytoma, Benign Fibrous / Q000276:immunology* / Q000628:therapy; D007694:Killer Cells, Natural / Q000276:immunology*; D010766:Phosphorylation; D051381:Rats; D017208:Rats, Wistar; D014407:Tumor Cells, Cultured; D014443:Tyrosine / Q000378:metabolism
D014443:Tyrosine