title: Is mechanical bowel preparation necessary before primary colonic anastomosis? An experimental study.
abstract: The necessity of preoperative or intraoperative mechanical bowel preparation of the colon, before primary anastomosis, has been recently challenged in clinical elective and emergency situations.
  
  
  OBJECTIVE
  This experimental study in dogs investigated the safety of segmental resection and primary anastomosis in the unprepared or loaded colon.
  
  
  METHODS
  Two segments of the descended colon were resected and anastomosed in each animal. Group I (12 anastomoses) received preoperative mechanical bowel preparation; the colon was not prepared in Group II (16 anastomoses); in Group III (12 anastomoses), a preliminary distal colonic obstruction was produced, and during the subsequent resection the colon was loaded. Postoperatively, animals were observed clinically, and anastomoses were assessed at autopsy on the ninth day.
  
  
  RESULTS
  All animals recovered uneventfully. At autopsy there was no evidence of anastomotic leakage.
  
  
  CONCLUSIONS
  In light of recent clinical reports and this experimental study, the ritual of mechanical bowel preparation should be further scrutinized.
authors.affiliation: Department of Surgery, Medical College of Wisconsin, Milwaukee.
authors.forename: M
authors.initials: M
authors.lastname: Schein
authors.forename: A
authors.initials: A
authors.lastname: Assalia
authors.forename: S
authors.initials: S
authors.lastname: Eldar
authors.forename: D H
authors.initials: DH
authors.lastname: Wittmann
mesh_terms: D000714:Anastomosis, Surgical; D000818:Animals; D003106:Colon / Q000601:surgery*; D004285:Dogs; D011300:Preoperative Care; D007507:Therapeutic Irrigation