Hypersensitivity of zidovudine: report of a case of anaphylaxis and review of the literature.
Hypersensitivity to zidovudine is an uncommon complication of antiretroviral therapy. Manifestations range from isolated fever to anaphylaxis. Fever and rash are the most common features. Diagnosis is made by rechallenge, although some patients have antibodies to zidovudine. Treatment is supportive, and symptoms resolve on withdrawal of the medication.
Wassef
M
M
Division of Infectious Diseases, University of Texas, Dallas, USA.
Keiser
P
P
D000328:Adult; D000707:Anaphylaxis / Q000139:chemically induced*; D004342:Drug Hypersensitivity / Q000209:etiology*; D006801:Humans; D008297:Male; D015662:Trimethoprim, Sulfamethoxazole Drug Combination / Q000009:adverse effects; D015215:Zidovudine / Q000009:adverse effects*
D015215:Zidovudine; D015662:Trimethoprim, Sulfamethoxazole Drug Combination