[Multiple cutaneous neoplasms in cyclosporine therapy after kidney transplantation].
We report on a 56-year-old renal allograft recipient receiving cyclosporin A immunosuppression. During this therapy he subsequently developed the following cutaneous neoplasms: squamous cell carcinomas, basal cell carcinomas, Bowen's disease, actinic keratosis, sebaceous hyperplasia, a dysplastic naevus and, finally a nodular malignant melanoma. Adverse effects of the cyclosporin A therapy are discussed, with special reference to dermatologic effects and the implications for patient and doctor.
Köhler
L D
LD
Dermatologische Klinik und Poliklinik, Technischen Universität, München.
Kautzky
F
F
Vogt
H J
HJ
D001913:Bowen's Disease / Q000139:chemically induced / Q000276:immunology; D002280:Basal Cell Carcinoma / Q000139:chemically induced / Q000276:immunology; D002294:Carcinoma, Squamous Cell / Q000139:chemically induced / Q000276:immunology; D002471:Cell Transformation, Neoplastic / Q000139:chemically induced / Q000276:immunology; D016572:Cyclosporine / Q000008:administration & dosage / Q000009:adverse effects*; D003928:Diabetic Nephropathies / Q000276:immunology / Q000601:surgery*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004416:Dysplastic Nevus Syndrome / Q000139:chemically induced / Q000276:immunology; D005500:Follow-Up Studies; D006801:Humans; D007108:Immune Tolerance / Q000187:drug effects; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male; D008545:Melanoma / Q000139:chemically induced / Q000276:immunology; D008875:Middle Aged; D009378:Neoplasms, Multiple Primary / Q000139:chemically induced* / Q000276:immunology; D011230:Precancerous Conditions / Q000139:chemically induced / Q000276:immunology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000276:immunology
D016572:Cyclosporine