Effect of sucralfate on gastric emptying and mucus under stress in rats.
The effect of sucralfate on gastric emptying, gastric mucus production, and ulcer formation in cold-restraint rats was studied. The rats were treated with sucralfate in doses of 100 mg/kg, 250 mg/kg and 500 mg/kg. Sucralfate prevented ulcer formation dose dependently. This effect was maximum at doses of 500 mg/kg (P < 0.001). Administration of sucralfate lowered the increased gastric emptying rate and increased gastric mucus production. This effect was not dose dependent. It was found that the ulcer-preventive effect of sucralfate was due to a lowered gastric emptying rate and increased mucus production in addition to other mechanisms.
Alhan
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Department of Surgery, Karadeniz Technical University, Trabzon, Turkey.
Küçüktülü
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U
Calìk
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Cinel
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A
D000423:Alcian Blue / Q000378:metabolism; D000818:Animals; D003080:Cold Temperature; D005746:Gastric Emptying / Q000187:drug effects*; D005753:Gastric Mucosa / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009093:Mucus / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D013276:Stomach Ulcer / Q000517:prevention & control*; D013312:Stress, Physiological; D013392:Sucralfate / Q000494:pharmacology* / Q000627:therapeutic use
D013392:Sucralfate; D000423:Alcian Blue