title: Balloon aortic valvuloplasty in adults: failure of procedure to improve long-term survival.
abstract: OBJECTIVE
  This study sought to determine the long-term outcome of adult patients undergoing percutaneous balloon aortic valvuloplasty.
  
  
  BACKGROUND
  Percutaneous balloon aortic valvuloplasty has been offered as an alternative to aortic valve replacement for selected patients with valvular aortic stenosis. Although balloon aortic valvuloplasty produces an immediate reduction in the transvalvular aortic gradient, a high incidence of restenosis frequently leads to recurrent symptoms. Therefore, it is unclear whether balloon aortic valvuloplasty impacts on the long-term outcome of these patients.
  
  
  METHODS
  Clinical, hemodynamic and echocardiographic data were collected at baseline in 165 patients undergoing balloon aortic valvuloplasty and examined for their ability to predict long-term outcome.
  
  
  RESULTS
  The median duration follow-up was 3.9 years (range 1 to 6). Ninety-nine percent follow-up was achieved. During this 6-year period, 152 patients (93%) died or underwent aortic valve replacement, and 99 (60%) died of cardiac-related causes. The probability of event-free survival (freedom from death, aortic valve replacement or repeat balloon aortic valvuloplasty) 1, 2 and 3 years after valvuloplasty was 40%, 19% and 6%, respectively. In contrast, the probability of survival 3 years after balloon aortic valvuloplasty in a subset of 42 patients who underwent subsequent aortic valve replacement was 84%. Survival after aortic valvuloplasty was poor regardless of the presenting symptom, but patients with New York Heart Association functional class IV congestive heart failure had events earliest. Univariable predictors of decreased event-free survival were younger age, advanced congestive heart failure symptoms, lower ejection fraction, elevated left ventricular end-diastolic pressure, presence of coronary artery disease and increased left ventricular internal diastolic diameter. Stepwise multivariable logistic regression analysis found that only younger age and a lower left ventricular ejection fraction contributed independent adverse prognostic information (chi-square 14.89, p = 0.0006).
  
  
  CONCLUSIONS
  Long-term event-free and actuarial survival after balloon aortic valvuloplasty is dismal and resembles the natural history of untreated aortic stenosis. Aortic valve replacement may be performed in selected subjects with good results. However, the prognosis for the remainder of patients who are not candidates for aortic valve replacement is particularly poor.
authors.affiliation: Duke University Medical Center, Division of Cardiology, Durham, North Carolina 27710, USA.
authors.forename: E B
authors.initials: EB
authors.lastname: Lieberman
authors.forename: T M
authors.initials: TM
authors.lastname: Bashore
authors.forename: J B
authors.initials: JB
authors.lastname: Hermiller
authors.forename: J S
authors.initials: JS
authors.lastname: Wilson
authors.forename: K S
authors.initials: KS
authors.lastname: Pieper
authors.forename: G P
authors.initials: GP
authors.lastname: Keeler
authors.forename: C H
authors.initials: CH
authors.lastname: Pierce
authors.forename: K B
authors.initials: KB
authors.lastname: Kisslo
authors.forename: J K
authors.initials: JK
authors.lastname: Harrison
authors.forename: C J
authors.initials: CJ
authors.lastname: Davidson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001024:Aortic Valve Stenosis / Q000000981:diagnostic imaging / Q000628:therapy*; D002404:Catheterization; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016016:Proportional Hazards Models; D012008:Recurrence; D016019:Survival Analysis; D016896:Treatment Outcome