title: Identification of human liver cytochrome P450s involved in the microsomal metabolism of the antihistaminic drug loratadine.
authors.affiliation: Department of Drug Metabolism and Pharmacokinetics, Schering-Plough Research Institute, Lafayette, NJ 07848-0032, USA.
authors.forename: N
authors.initials: N
authors.lastname: Yumibe
authors.forename: K
authors.initials: K
authors.lastname: Huie
authors.forename: K J
authors.initials: KJ
authors.lastname: Chen
authors.forename: R P
authors.initials: RP
authors.lastname: Clement
authors.forename: M N
authors.initials: MN
authors.lastname: Cayen
mesh_terms: D019389:Cytochrome P-450 CYP2D6; D051544:Cytochrome P-450 CYP3A; D065607:Cytochrome P-450 Enzyme Inhibitors; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D006801:Humans; D008658:Inactivation, Metabolic; D017336:Loratadine / Q000493:pharmacokinetics* / Q000031:analogs & derivatives; D008862:Microsomes, Liver / Q000201:enzymology*; D006899:Mixed Function Oxygenases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D010880:Piperidines / Q000378:metabolism; D011725:Pyridines / Q000378:metabolism
chemical_list: D065607:Cytochrome P-450 Enzyme Inhibitors; D010880:Piperidines; D011725:Pyridines; D017336:Loratadine; D003577:Cytochrome P-450 Enzyme System; D006899:Mixed Function Oxygenases; C104464:CYP3A protein, human; D019389:Cytochrome P-450 CYP2D6; D051544:Cytochrome P-450 CYP3A; C121345:desloratadine