title: Primary non-Hodgkin's lymphoma of the vagina. Case report and review of the literature.
abstract: The genital tract as primary site of malignant non-Hodgkin's lymphoma in women is extremely rare, whereas secondary involvement in advanced disease is found in about 40% of cases. In this report a patient is presented who had a primary vaginal non-Hodgkin's lymphoma of the centroblastic type according to the Kiel classification, with an excellent response to cytotoxic chemotherapy (CHOP) and event-free disease for 3 years. A review of the literature shows that favorable prognosis of localized disease seems to be a common experience. Primary involvement of the vagina can be successfully treated by pelvic irradiation, but in young women cytotoxic chemotherapy should be considered to preserve fertility.
authors.affiliation: Division of Hematology, Department of Medicine, University of Essen, Germany.
authors.forename: H G
authors.initials: HG
authors.lastname: Höffkes
authors.forename: A
authors.initials: A
authors.lastname: Schumann
authors.forename: M
authors.initials: M
authors.lastname: Uppenkamp
authors.forename: C
authors.initials: C
authors.lastname: Teschendorf
authors.forename: A E
authors.initials: AE
authors.lastname: Schindler
authors.forename: R
authors.initials: R
authors.lastname: Parwaresch
authors.forename: G
authors.initials: G
authors.lastname: Brittinger
mesh_terms: D000328:Adult; D000970:Antineoplastic Agents / Q000627:therapeutic use; D005260:Female; D006801:Humans; D008228:Lymphoma, Non-Hodgkin / Q000188:drug therapy / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000188:drug therapy / Q000473:pathology*
chemical_list: D000970:Antineoplastic Agents