Argyrophilic nucleolar organizer regions and proliferating cell nuclear antigen/cyclin in Kaposi's sarcoma. Comparison with morphology and with immunoperoxidase staining for factor VIII-related antigen.
The proposal that Kaposi's sarcoma undergoes cellular transformation from early to late stages was studied with argyrophilic nucleolar organizer regions, proliferating cell nuclear antigen/cyclin, and immunoperoxidase staining for factor VIII-related antigen. Staining of argyrophilic nucleolar organizer regions was significantly increased in the plaque/nodular stage compared to the patch stage. The endothelial-selective marker factor VIII-related antigen stained more intensely in patch stage lesions. This was inversely correlated with staining of argyrophilic nucleolar organizer regions. Proliferating cell nuclear antigen/cyclin staining did not correlate with tumor stage or with factor VIII-related antigen. The changes in argyrophilic nucleolar organizer regions and factor VIII-related antigen staining are evidence for cellular transformation in Kaposi's sarcoma.
Haupt
H M
HM
Department of Pathology, Pennsylvania Hospital, Philadelphia 19107, USA.
Stern
J B
JB
Multhaupt
H
H
Newman
H W
HW
D006801:Humans; D007124:Immunoenzyme Techniques; D009697:Nucleolus Organizer Region / Q000737:chemistry* / Q000473:pathology*; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D012514:Sarcoma, Kaposi / Q000737:chemistry* / Q000473:pathology*; D016622:Silver Staining; D014841:von Willebrand Factor / Q000032:analysis*
D018809:Proliferating Cell Nuclear Antigen; D014841:von Willebrand Factor