Antagonism of the synaptic depressant actions of L-AP4 in the lateral perforant path by MAP4.
A new mGluR antagonist, MAP4 (the alpha-methyl derivative of L-AP4), was found to antagonize the synaptic depressant actions of L-AP4 at the lateral perforant path synapse, in rat hippocampal slices.
Bushell
T J
TJ
Department of Anatomy, University of Bristol, School of Medical Sciences, U.K.
Jane
D E
DE
Tse
H W
HW
Watkins
J C
JC
Davies
C H
CH
Garthwaite
J
J
Collingridge
G L
GL
D000818:Animals; D002087:Butyrates / Q000494:pharmacology*; D020148:Butyric Acid; D006624:Hippocampus / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects*; D008869:Microtubule-Associated Proteins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors
D002087:Butyrates; D008869:Microtubule-Associated Proteins; D020148:Butyric Acid