Central motor reorganization after anastomosis of the musculocutaneous and intercostal nerves following cervical root avulsion.
In 4 patients with a complete upper limb palsy due to traumatic cervical root avulsion, surgical anastomosis of intercostal to musculocutaneous nerves was performed to restore function in the biceps brachii muscle. Four to 6 months after the operation, motor unit discharges were recorded from the biceps muscle on the operated side during deep breathing and by cortical magnetic stimulation. The motor unit discharges became independent from respirations gradually over 1 to 2 years. The latencies of the motor potentials evoked by cortical and thoracic root magnetic stimulation decreased gradually over 2 to 3 years. Motor cortex mapping of the reinnervated biceps muscle showed a gradual change over 4 to 33 months from the area of the intercostal muscles to that of the arm area, which was more lateral on the motor cortex. These findings suggest that reorganization of the motor cortex to arm flexor muscles occurs following peripheral nerve anastomosis.
Mano
Y
Y
Department of Neurology, Nara Medical University, Japan.
Nakamuro
T
T
Tamura
R
R
Takayanagi
T
T
Kawanishi
K
K
Tamai
S
S
Mayer
R F
RF
D000063:Accidents, Traffic; D000293:Adolescent; D000328:Adult; D000714:Anastomosis, Surgical; D001132:Arm / Q000294:innervation*; D001921:Brain / Q000503:physiopathology; D001931:Brain Mapping; D004576:Electromyography; D005071:Evoked Potentials / Q000502:physiology; D006801:Humans; D007367:Intercostal Nerves / Q000601:surgery*; D008280:Magnetics; D008297:Male; D009049:Motorcycles; D009132:Muscles / Q000294:innervation* / Q000503:physiopathology; D009138:Musculocutaneous Nerve / Q000601:surgery*; D009416:Nerve Regeneration / Q000502:physiology; D010243:Paralysis / Q000503:physiopathology* / Q000601:surgery; D011930:Reaction Time / Q000502:physiology; D013126:Spinal Nerve Roots / Q000293:injuries*