title: White matter abnormalities in congenital muscular dystrophy.
abstract: Central nervous system (CNS) characteristics were examined in seventeen patients with autosomal recessive classic or "pure" congenital muscular dystrophy (CMD). In three patients, neuroradiological examination (CT/MRI) indicated hypodense white matter areas. Two out of these three patients had epilepsy (seizures and epileptic discharges on their EEG). Only two of the remaining patients had epileptic EEG discharges, but without clinical seizures. By comparing our results to data in the literature, we could conclude that the classic or "pure" form of CMD can be subdivided into two subtypes, i.e. those with and those without white matter hypodensities. A mild form of epilepsy or an epileptic predisposition on EEG can be part of the subtype with white matter hypodensities.
authors.affiliation: Department of Child Neurology, University Hospital Nijmegen, The Netherlands.
authors.forename: Q H
authors.initials: QH
authors.lastname: Leyten
authors.forename: F J
authors.initials: FJ
authors.lastname: Gabreëls
authors.forename: W O
authors.initials: WO
authors.lastname: Renier
authors.forename: B G
authors.initials: BG
authors.lastname: van Engelen
authors.forename: H J
authors.initials: HJ
authors.lastname: ter Laak
authors.forename: R C
authors.initials: RC
authors.lastname: Sengers
authors.forename: H O
authors.initials: HO
authors.lastname: Thijssen
mesh_terms: D000293:Adolescent; D001921:Brain / Q000000981:diagnostic imaging / Q000473:pathology*; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D004827:Epilepsy / Q000209:etiology; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D009136:Muscular Dystrophies / Q000150:complications / Q000151:congenital* / Q000000981:diagnostic imaging / Q000473:pathology; D012189:Retrospective Studies; D014057:Tomography, X-Ray Computed