title: Microalbuminuria is not associated with cardiovascular disease in patients with homozygous familial hypercholesterolaemia.
abstract: Microalbuminuria is thought to be a predictor of cardiovascular disease (CVD). A high prevalence of microalbuminuria might therefore be expected in patients with homozygous familial hypercholesterolaemia (HFH), as they develop severe premature atherosclerosis. We tested for this in 15 HFH patients (M = 9, F = 6; mean age 19.3 years). Urinary albumin excretion (UAER) were normal in all patients [corrected]. In addition, there was no difference in the mean urinary albumin excretion rate (UAER) between those with documented CVD (n = 8; UAER = 5.17 micrograms/min) and those without (n = 7; UAER = 3.60 micrograms/min). There is therefore no association between microalbuminuria and CVD in HFH.
authors.affiliation: Carbohydrate and Lipid Metabolism Research Group, University of the Witwatersrand, Johannesburg, South Africa.
authors.forename: M
authors.initials: M
authors.lastname: Zouvanis
authors.forename: F J
authors.initials: FJ
authors.lastname: Raal
authors.forename: B I
authors.initials: BI
authors.lastname: Joffe
authors.forename: H C
authors.initials: HC
authors.lastname: Seftel
mesh_terms: D000293:Adolescent; D000328:Adult; D000419:Albuminuria / Q000209:etiology* / Q000652:urine; D002318:Cardiovascular Diseases / Q000150:complications* / Q000652:urine; D002648:Child; D002675:Child, Preschool; D003404:Creatinine / Q000652:urine; D005260:Female; D006720:Homozygote; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000150:complications* / Q000235:genetics / Q000652:urine; D008297:Male; D015995:Prevalence
chemical_list: D003404:Creatinine