title: Second messengers in the cochlea.
abstract: Second messengers are vital to the regulation of nearly every aspect of cellular physiology. Evidence is reviewed for the role of second messengers in cochlear fluid homeostasis, hair cell adaptation, motility and synaptic activity. We suggest that the elucidation of the role of second messengers in the regulation of cochlear physiology will be important for the therapeutic management of otopathologies and the side effects of ototoxic agents.
authors.affiliation: Kresge Hearing Research Institute, University of Michigan, Ann Arbor, USA.
authors.forename: D E
authors.initials: DE
authors.lastname: Coling
authors.forename: J
authors.initials: J
authors.lastname: Schacht
mesh_terms: D000249:Adenosine Monophosphate / Q000502:physiology*; D003051:Cochlea / Q000502:physiology*; D004075:Diglycerides / Q000502:physiology*; D006157:Guanosine Monophosphate / Q000502:physiology*; D006198:Hair Cells, Auditory / Q000502:physiology; D006801:Humans; D015544:Inositol 1,4,5-Trisphosphate / Q000502:physiology*; D013569:Synapses / Q000502:physiology
chemical_list: D004075:Diglycerides; D000249:Adenosine Monophosphate; D006157:Guanosine Monophosphate; D015544:Inositol 1,4,5-Trisphosphate