A comparative study on the mechanism of the anticoagulant action of mollusc and mammalian heparins.
The anticlotting activities on some steps of the coagulation cascade of mollusc and mammalian heparins were studied. AT III-high affinity heparin is a more potent inhibitor than unfractionated heparin and mollusc heparin in the intrinsic and extrinsic pathways of thrombin and factor Xa generation. Mollusan heparin has about the same activity as the AT III high affinity-heparin on the inhibition of factor Xa and thrombin in the presence of antithrombin III and four times more inhibitory activity than unfractionated heparin on the heparin cofactor II mediated inhibition of thrombin.
Paiva
J F
JF
Departamento de Bioquímica, Universidade Federal do Rio Grande do Norte, Natal, R.N., Brazil.
Santos
E A
EA
Jeske
W
W
Fareed
J
J
Nader
H B
HB
Dietrich
C P
CP
D000818:Animals; D000925:Anticoagulants / Q000737:chemistry / Q000494:pharmacology*; D000990:Antithrombin III / Q000378:metabolism; D002851:Chromatography, High Pressure Liquid; D015951:Factor Xa / Q000378:metabolism; D006493:Heparin / Q000737:chemistry / Q000494:pharmacology*; D015844:Heparin Cofactor II / Q000378:metabolism; D008297:Male; D008322:Mammals / Q000378:metabolism*; D008970:Molecular Weight; D008974:Mollusca / Q000378:metabolism*; D011817:Rabbits; D011945:Receptors, Angiotensin / Q000187:drug effects / Q000378:metabolism; D013917:Thrombin / Q000378:metabolism
D000925:Anticoagulants; D011945:Receptors, Angiotensin; D015844:Heparin Cofactor II; D000990:Antithrombin III; D006493:Heparin; D013917:Thrombin; D015951:Factor Xa