Lysophosphatidic acid signalling.
Lysophosphatidic acid is an intercellular phospholipid messenger that is released from platelets (and probably other cells) and evokes multiple biological responses, ranging from induction of mitogenesis to neurite retraction, by activating a specific G protein coupled receptor. Recent studies indicate that the lysophosphatidic acid receptor acts via the small GTP-binding proteins Ras and Rho to stimulate cell proliferation and to trigger actin-based cytoskeletal events, respectively.
Moolenaar
W H
WH
Division of Cellular Biochemistry, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
D000818:Animals; D019204:GTP-Binding Proteins / Q000378:metabolism; D006801:Humans; D008246:Lysophospholipids / Q000502:physiology*; D010766:Phosphorylation; D016283:Proto-Oncogene Proteins p21(ras) / Q000502:physiology; D015290:Second Messenger Systems / Q000502:physiology; D015398:Signal Transduction / Q000502:physiology*
D008246:Lysophospholipids; D019204:GTP-Binding Proteins; C501009:HRAS protein, human; D016283:Proto-Oncogene Proteins p21(ras)