title: Corticospinal tract degeneration in motor neuron disease.
abstract: Long-repetition-time spin-echo MR images showed symmetric hyperintensity of the intracerebral corticospinal tracts in two patients with clinical and neurophysiologic diagnosis of primary lateral sclerosis and amyotrophic lateral sclerosis. In both, axial low-flip-angle gradient-echo images of the cervical spine showed hyperintensity of the lateral columns of the cord consistent with antegrade degeneration of the crossed corticospinal tracts.
authors.affiliation: Cattedra di Radiologia, Universitá di Pisa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Mascalchi
authors.forename: F
authors.initials: F
authors.lastname: Salvi
authors.forename: F
authors.initials: F
authors.lastname: Valzania
authors.forename: G
authors.initials: G
authors.lastname: Marcacci
authors.forename: C
authors.initials: C
authors.lastname: Bartolozzi
authors.forename: C A
authors.initials: CA
authors.lastname: Tassinari
mesh_terms: D000328:Adult; D000690:Amyotrophic Lateral Sclerosis / Q000175:diagnosis* / Q000503:physiopathology; D001921:Brain / Q000473:pathology / Q000503:physiopathology; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009410:Nerve Degeneration / Q000502:physiology*; D011712:Pyramidal Tracts / Q000473:pathology* / Q000503:physiopathology; D013116:Spinal Cord / Q000473:pathology / Q000503:physiopathology; D009435:Synaptic Transmission / Q000502:physiology