Neuroleptic malignant syndrome in a parkinsonian woman during the premenstrual period.
A 45-year-old woman with Parkinson's disease developed neuroleptic malignant syndrome (NMS) despite lack of levodopa withdrawal. She experienced two episodes characterized by indomethacin-resistant hyperthermia, hyperhidrosis, and aggravation of parkinsonism. The symptoms, however, disappeared during menstruation. We suggest that the development of NMS may depend, in part, upon the hormonal state.
Mizuta
E
E
Department of Neurology, Utano National Hospital, Kyoto, Japan.
Yamasaki
S
S
Nakatake
M
M
Kuno
S
S
D001831:Body Temperature; D002230:Carbidopa / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008597:Menstrual Cycle; D008875:Middle Aged; D009459:Neuroleptic Malignant Syndrome / Q000209:etiology / Q000503:physiopathology*; D010300:Parkinson Disease / Q000150:complications / Q000188:drug therapy / Q000503:physiopathology*
D004338:Drug Combinations; D007980:Levodopa; D002230:Carbidopa