Interactions of TCR tyrosine based activation motifs with tyrosine kinases.
The tyrosine activating motif (TAM) is a conserved signaling motif present in many hematopoietic receptors. Although the exact definition and the function of these motifs is not known, it is likely that these motifs bind and activate protein tyrosine kinases. Here we summarize the data regarding tyrosine kinase interactions with the T cell receptor TAMs and integrate much of the information into a functional and testable model. We propose that phosphorylated TAMs are important for the activation of tyrosine kinases as well as for the recruitment of critical signaling molecules.
Shaw
A S
AS
Center for Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.
Gauen
L K
LK
Zhu
Y
Y
D000595:Amino Acid Sequence; D017124:Conserved Sequence; D004789:Enzyme Activation / Q000276:immunology; D004792:Enzyme Precursors / Q000276:immunology / Q000378:metabolism; D015971:Gene Expression Regulation, Enzymologic; D047908:Intracellular Signaling Peptides and Proteins; D008213:Lymphocyte Activation; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D008214:Lymphocytes / Q000276:immunology / Q000378:metabolism; D018448:Models, Immunological; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000276:immunology / Q000378:metabolism; D010766:Phosphorylation; D011505:Protein-Tyrosine Kinases / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D011518:Proto-Oncogene Proteins / Q000276:immunology / Q000378:metabolism; D051076:Proto-Oncogene Proteins c-fyn; D011948:Receptors, Antigen, T-Cell / Q000235:genetics / Q000276:immunology / Q000378:metabolism*; D016415:Sequence Alignment; D015398:Signal Transduction / Q000276:immunology; D000072377:Syk Kinase; D051746:ZAP-70 Protein-Tyrosine Kinase
D004792:Enzyme Precursors; D047908:Intracellular Signaling Peptides and Proteins; D009856:Oncogene Proteins, Viral; D011518:Proto-Oncogene Proteins; D011948:Receptors, Antigen, T-Cell; D011505:Protein-Tyrosine Kinases; D019860:Lymphocyte Specific Protein Tyrosine Kinase p56(lck); D051076:Proto-Oncogene Proteins c-fyn; D000072377:Syk Kinase; D051746:ZAP-70 Protein-Tyrosine Kinase