title: Current status of adjuvant systemic therapy for primary breast cancer: progress and controversy.
abstract: Results from studies of adjuvant systemic therapy for primary breast cancer accumulated over the past 20 years have clearly established that this treatment approach improves disease-free and overall survival rates in high-risk patients. As a result, adjuvant systemic therapy has become an integral component of the modern, multimodality approach to management of primary breast cancer. However, controversies about the most effective approaches remain, and research continues. This article reviews the current status of adjuvant systemic therapy for primary breast cancer and discusses areas of persistent controversy.
authors.affiliation: Department of Breast and Gynecologic Medical Oncology, University of Texas M.D. Anderson Center in Houston, USA.
authors.forename: G N
authors.initials: GN
authors.lastname: Hortobagyi
authors.forename: A U
authors.initials: AU
authors.lastname: Buzdar
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality / Q000628:therapy*; D018567:Breast Neoplasms, Male / Q000628:therapy; D003131:Combined Modality Therapy; D005260:Female; D006801:Humans; D008297:Male; D008495:Medical Oncology / Q000639:trends*; D016032:Randomized Controlled Trials as Topic; D016019:Survival Analysis