Parathyroid hormone related protein in oral squamous cell carcinomas invading the mandible.
OBJECTIVE
To assess parathyroid hormone related protein (PTHrP) as a candidate biochemical marker of invasion of the mandible by oral squamous cell carcinoma.


METHODS
Tumour PTHrP concentrations were quantitated by immunoassay, and PTHrP was detected by immunohistochemistry, in a cohort of 24 primary squamous cell carcinomas of the mandible.


RESULTS
PTHrP was identified in all tumours examined, but no correlation was found between scores of the intensity and/or consistency of staining or tumour PTHrP concentrations and the histological classification of tumour invasion.


CONCLUSIONS
Although PTHrP was present in all squamous tumours studied, there was no correlation between PTHrP expression and pattern of tumour invasion. However, tumour derived PTHrP may act locally to influence tumour growth and differentiation and resorption of bone.
Dunne
F P
FP
Department of Medicine, Queen Elizabeth Hospital, Edgbaston, Birmingham.
Bowden
S J
SJ
Brown
J S
JS
Ratcliffe
W A
WA
Browne
R M
RM
D014408:Biomarkers, Tumor / Q000032:analysis*; D002294:Carcinoma, Squamous Cell / Q000737:chemistry* / Q000473:pathology / Q000556:secondary; D002850:Chromatography, Gel; D006801:Humans; D007124:Immunoenzyme Techniques; D008339:Mandibular Neoplasms / Q000737:chemistry* / Q000556:secondary; D009062:Mouth Neoplasms / Q000737:chemistry* / Q000473:pathology; D009361:Neoplasm Invasiveness; D009363:Neoplasm Proteins / Q000032:analysis; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins / Q000032:analysis*
D014408:Biomarkers, Tumor; D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins