Intensity of Schistosoma mansoni infection determines alterations in hepatic drug metabolism.
Zoxazolamine paralysis times have been used as a probe to measure the activities of cytochrome P450 1A1 in mice in vivo. The results indicate that male and female mice of the BALB/c and CBA/J strain do not show altered paralysis times if infected with less than 4 worm pairs. Alterations were observed only in animals harbouring more than 5 worm pairs irrespective of the sex or strain of mouse being used. The study has extended the findings of other workers showing that mice infected with fewer than 4-5 worm pairs of S. mansoni do not show any alteration in the metabolism of pentobarbital in vivo.
Naik
Y S
YS
Department of Biochemistry, University of Zimbabwe, Mount Pleasant, Harare.
Hasler
J A
JA
D000818:Animals; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D005260:Female; D008658:Inactivation, Metabolic; D008099:Liver / Q000378:metabolism* / Q000469:parasitology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D010243:Paralysis / Q000139:chemically induced; D012550:Schistosoma mansoni / Q000502:physiology*; D012555:Schistosomiasis mansoni / Q000378:metabolism* / Q000469:parasitology; D015049:Zoxazolamine / Q000493:pharmacokinetics* / Q000494:pharmacology
D003577:Cytochrome P-450 Enzyme System; D015049:Zoxazolamine