Modification of cytokine secretion following mild emotional stimuli.
In the present study, changes in the cytokine system (IL-1 beta, IL-2, IL-3, IL-6 and TNF alpha) were assessed following exposure to mild mood induction (negative and positive) in humans. An increase in secretion of TNF alpha, a decrease in that of IL-2 and of IL-3 with no change in IL-1 beta and in IL-6 secretion levels, was observed in response to mild negative emotional changes. A reversed cytokine secretion profile was found following positive mood changes, suggesting the hypothalamic-pituitary-adrenal axis and the autonomic nervous system, as possible mediators underlying these effects, specific to the nature of the emotion.
Mittwoch-Jaffe
T
T
Psychopharmacology Laboratory, Bar Ilan University, Ramat Gan, Israel.
Shalit
F
F
Srendi
B
B
Yehuda
S
S
D000293:Adolescent; D000328:Adult; D000339:Affect / Q000502:physiology*; D005260:Female; D006801:Humans; D007109:Immunity / Q000502:physiology*; D007378:Interleukins / Q000378:metabolism*; D008297:Male; D008954:Models, Biological; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
D007378:Interleukins; D014409:Tumor Necrosis Factor-alpha