title: Narcolepsy associated with arteriovenous malformation of the diencephalon.
abstract: Narcolepsy associated with localized brain lesions is rare, and few reports of well-documented cases have been published. We describe the case of a 20-year-old male (HLA DQw1 negative) who fulfilled clinical and polygraphic criteria of symptomatic narcolepsy. Narcolepsy in this patient was associated with an arteriovenous malformation involving the structures around the third ventricle. Clinical symptoms improved after embolization and radiosurgery. These findings support the hypothesis that lesions in the vicinity of the third ventricle can cause symptomatic narcolepsy.
authors.affiliation: Department of Neurology, Hôpital Fontmaure, Chamalieres, France.
authors.forename: P
authors.initials: P
authors.lastname: Clavelou
authors.forename: M
authors.initials: M
authors.lastname: Tournilhac
authors.forename: C
authors.initials: C
authors.lastname: Vidal
authors.forename: A M
authors.initials: AM
authors.lastname: Georget
authors.forename: L
authors.initials: L
authors.lastname: Picard
authors.forename: L
authors.initials: L
authors.lastname: Merienne
mesh_terms: D000328:Adult; D002533:Cerebral Angiography; D002997:Clomipramine / Q000627:therapeutic use; D004027:Diencephalon / Q000098:blood supply* / Q000503:physiopathology; D006680:HLA Antigens; D006801:Humans; D002538:Intracranial Arteriovenous Malformations / Q000150:complications* / Q000175:diagnosis / Q000503:physiopathology; D008279:Magnetic Resonance Imaging; D008297:Male; D009290:Narcolepsy / Q000188:drug therapy / Q000209:etiology*; D011388:Prolactin / Q000097:blood; D012895:Sleep, REM
chemical_list: D006680:HLA Antigens; D011388:Prolactin; D002997:Clomipramine