title: [Nasal BiPAP (bilevel positive airway pressure) respiration with controlled respiratory mode in neuromuscular diseases and severe kyphoscoliosis].
abstract: The BiPAP-System is a useful ventilatory support for patients with severe sleep apnea and need for high inspiratory pressure. Using the BiPAP as a full ventilatory support is new due to the recent addition of a timed control modus and individual control of inspiratory time. We used the new BiPAP ST-System in one young men with Duchenne-disease, one man with heredo ataxia (Friedreich), one women with spinal muscular atrophy, one man with central sleep apnea due to brainstem infarction as well as two women and one men with severe kyphoscoliosis. All patients had a significant hypoventilation and hypoxemia at night, which was documented by polysomnography. Mechanical ventilation at night with nasal BiPAP increased the baseline oxygen saturation (SaO2) by an average of 11.9% in all seven patients. The frequency of desaturations below 90% diminished by an average of 81%. The lowest SaO2 measured increased by 28% in all seven patients combined. Rhinitis due to the dryness of the inspired air were noticed in only two patients. Two other patients needed adaptation to the customized mask. The nasal BiPAP-System using the T-mode is a useful device to support ventilation at night and thus it could replace ventilatory support by the IPPV-mode in many patients.
authors.affiliation: Abteilung Pneumologie, Medizinische Universitätsklinik, Freiburg.
authors.forename: N
authors.initials: N
authors.lastname: Netzer
authors.forename: P
authors.initials: P
authors.lastname: Werner
authors.forename: R
authors.initials: R
authors.lastname: Korinthenberg
authors.forename: H
authors.initials: H
authors.lastname: Matthys
mesh_terms: D000328:Adult; D002245:Carbon Dioxide / Q000097:blood; D004867:Equipment Design; D005260:Female; D006801:Humans; D000860:Hypoxia / Q000209:etiology / Q000628:therapy*; D007738:Kyphosis / Q000150:complications / Q000209:etiology / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D009468:Neuromuscular Diseases / Q000150:complications / Q000209:etiology / Q000628:therapy*; D010100:Oxygen / Q000097:blood; D011175:Positive-Pressure Respiration / Q000295:instrumentation*; D012600:Scoliosis / Q000150:complications / Q000209:etiology / Q000628:therapy*; D012891:Sleep Apnea Syndromes / Q000209:etiology / Q000628:therapy*
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen