title: Longitudinal characteristic curve of liver disease.
abstract: A longitudinal characteristic curve of chronic liver disease (LCC-LD) is derived for the first time by a new method of time series data analysis, where a hospital information system is utilized as a clinical research application of the database. It describes a typical pattern of development of disease from the beginning of chronic hepatitis to the final stage of cirrhosis. The LCC-LD is obtained by effectively using patient data with various stages of developments of liver disease and the present method is applicable to derive the LCC of other diseases. The obtained LCC-LD may be useful for a clinical decision making support such as the prospective assessment (for example, the onset time of cirrhosis) of liver disease in individual patients, an evaluation of drug effect, etc.
authors.affiliation: Center of Medical Information Science, Kochi Medical School, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Kitazoe
authors.forename: Y
authors.initials: Y
authors.lastname: Kurihara
authors.forename: Y
authors.initials: Y
authors.lastname: Okuhara
authors.forename: S
authors.initials: S
authors.lastname: Onishi
authors.forename: A
authors.initials: A
authors.lastname: Tomita
authors.forename: Y
authors.initials: Y
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Nishioka
authors.forename: M
authors.initials: M
authors.lastname: Sasaki
authors.forename: K
authors.initials: K
authors.lastname: Yamamoto
authors.forename: Y
authors.initials: Y
authors.lastname: Nose
mesh_terms: D000465:Algorithms; D015415:Biomarkers / Q000032:analysis; D002802:Cholinesterases / Q000032:analysis; D002908:Chronic Disease; D003661:Decision Support Techniques; D018450:Disease Progression; D004341:Drug Evaluation; D006525:Hepatitis, Viral, Human / Q000503:physiopathology; D006751:Hospital Information Systems; D006801:Humans; D008103:Liver Cirrhosis / Q000503:physiopathology; D008107:Liver Diseases / Q000503:physiopathology*; D008954:Models, Biological; D011379:Prognosis; D011446:Prospective Studies
chemical_list: D015415:Biomarkers; D002802:Cholinesterases