title: Alprazolam for tinnitus.
abstract: There is insufficient evidence to support the use of alprazolam in the treatment of tinnitus. The Johnson trial is the only study to date assessing the role of alprazolam, and at best it is an open-label trial demonstrating activity. There is a need for definitive double-blind, controlled, crossover studies of sufficient statistical power to resolve the issue. Furthermore, once efficacy is demonstrated, further studies are needed to determine the appropriate length of therapy, the necessity for maintenance therapy, the role of "drug holidays," appropriate dose tapering schedules, and a more careful delineation of which populations of patients are more likely to respond to alprazolam.
authors.affiliation: School of Pharmacy, University of California, San Francisco 94143, USA.
authors.forename: L
authors.initials: L
authors.lastname: Huynh
authors.forename: S
authors.initials: S
authors.lastname: Fields
mesh_terms: D000525:Alprazolam / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006801:Humans; D012107:Research Design; D014012:Tinnitus / Q000188:drug therapy*
chemical_list: D000525:Alprazolam