title: [Interrelationship between structural variants of the apolipoprotein B and ischemic heart disease and plasma lipid levels].
abstract: Xba I and EcoR I polymorphism of the apolipoprotein B (APOB) gene was studied by PCR. A significant increase in the frequency of allele X+ and haplotype H+E+ was demonstrated in patients with coronarographically documented coronary heart disease (CHD) over that of the general population. Association of allele E- with increased levels of serum triglycerides was found. The results provide evidence about the contribution of structural variants of the APOB gene to determining CHD.
authors.forename: V A
authors.initials: VA
authors.lastname: Stepanov
authors.forename: V P
authors.initials: VP
authors.lastname: Puzyrev
authors.forename: S V
authors.initials: SV
authors.lastname: Lemza
authors.forename: R S
authors.initials: RS
authors.lastname: Karpov
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Fedorov
mesh_terms: D000328:Adult; D000483:Alleles; D001055:Apolipoproteins B / Q000235:genetics*; D016022:Case-Control Studies; D003327:Coronary Disease / Q000097:blood / Q000235:genetics*; D005787:Gene Frequency; D005819:Genetic Markers; D014644:Genetic Variation; D006239:Haplotypes; D006801:Humans; D008055:Lipids / Q000097:blood*; D008297:Male; D008875:Middle Aged
chemical_list: D001055:Apolipoproteins B; D005819:Genetic Markers; D008055:Lipids