Diuretic and antidiuretic effects of mesotocin as compared with the antidiuretic effect of arginine vasotocin in the hen.
Mesotocin and arginine vasotocin were injected intravenously once at various dosage levels (.0025 to 25 micrograms/kg body weight) immediately after an intravenous injection of 15 mL/kg body weight saline solution into hens in which an artificial anus had been surgically created, and the volume of urine excreted during a 5-h period, following the injection, was measured. Arginine vasotocin caused a monophasic, dose-dependent decrease in urine volume. By contrast, mesotocin was biphasic: at .025 and .25 micrograms/kg body weight it decreased urine volume with the same efficacy as arginine vasotocin, whereas it dramatically increased urine volume at the higher doses (2.5 and 25 micrograms/kg body weight).
Takahashi
T
T
Department of Animal Science and Technology, Gifu University, Japan.
Kawashima
M
M
Yasuoka
T
T
Kamiyoshi
M
M
Tanaka
K
K
D000818:Animals; D002645:Chickens; D004231:Diuresis / Q000187:drug effects*; D004232:Diuretics / Q000494:pharmacology; D005260:Female; D010121:Oxytocin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014668:Vasotocin / Q000494:pharmacology*
D004232:Diuretics; C001713:mesotocin; D010121:Oxytocin; D014668:Vasotocin