A HinfI polymorphism in the 5' flanking region of the human VNTR locus D1S80.
A restriction fragment length polymorphism (RFLP) characterized by the presence (HinfI+) or absence (HinfI-) of a HinfI site has been found in the 5' flanking region of the VNTR locus D1S80. RFLP-allele frequencies were determined from 82 unrelated individuals: HinfI+ = 0.49, HinfI- = 0.51. The RFLP/VNTR haplotype frequencies show an absolute association between the HinfI+ allele and the VNTR allele of 18 repeat units and an extreme association between the HinfI- allele and the VNTR allele of 24 repeat units. The remaining VNTR alleles associate more randomly with the 2 flanking HinfI alleles.
Alonso
A
A
Instituto Nacional de Toxicologia, Sección de Biología, Madrid, Spain.
Martin
P
P
Albarrán
C
C
Sancho
M
M
D000328:Adult; D000483:Alleles; D002648:Child; D002874:Chromosome Mapping; D004268:DNA-Binding Proteins / Q000235:genetics*; D005260:Female; D005787:Gene Frequency; D005819:Genetic Markers / Q000235:genetics*; D006239:Haplotypes; D006801:Humans; D008297:Male; D018598:Minisatellite Repeats / Q000235:genetics*; D010334:Paternity; D012150:Polymorphism, Restriction Fragment Length; D013030:Spain
D004268:DNA-Binding Proteins; D005819:Genetic Markers