title: [Antimicrobial and antitrichomonal activity of 5-nitroimidazole derivatives in an in vitro experiment].
abstract: The comparative study on the antimicrobial activity of metronidazole and its complex with cobalt sulfate showed that the complex formation increased 2-4 times the metronidazole activity against elective anaerobes. The study of the drug action on Trichomonas spp. revealed that as a result of the complexing with cobalt sulfate the metronidazole efficacy against the Trichomonas strains isolated from the discharge of a female patient with metronidazole resistant trichomoniasis increased, the activating effect of the complex on the host cells being suggested.
authors.forename: A S
authors.initials: AS
authors.lastname: Seleznev
authors.forename: G A
authors.initials: GA
authors.lastname: Dmitriev
authors.forename: E E
authors.initials: EE
authors.lastname: Bragina
authors.forename: N I
authors.initials: NI
authors.lastname: Kaletina
authors.forename: L A
authors.initials: LA
authors.lastname: Pavlova
authors.forename: Ia V
authors.initials: IaV
authors.lastname: Murza
authors.forename: R A
authors.initials: RA
authors.lastname: Abdumalikov
mesh_terms: D003035:Cobalt / Q000737:chemistry*; D005260:Female; D006801:Humans; D008795:Metronidazole / Q000737:chemistry / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests
chemical_list: D008795:Metronidazole; D003035:Cobalt; C026305:cobalt sulfate