The genes for human brain factor 1 and 2, members of the fork head gene family, are clustered on chromosome 14q.
Brain factor-1 (BF-1) is a member of the fork head gene family which shows expression restricted to the neurons of the developing telencephalon in rodents and man. We have isolated a second human gene (HBF-2), which is also strongly expressed in embryonic brain and has very high homology to both the rat and human brain factor-1 genes and the retroviral oncogene qin. The HBF-2 cDNA was isolated from a human fetal brain expression library and contains a putative open reading frame of 479 amino acids. The HBF-2 gene is strongly expressed in fetal brain and also with lower levels of expression in several adult tissues. At the genomic level the gene for HBF-1 contains an 500 bp intron situated between the DNA binding domain II and the fork head domain while that of HBF-2 is intronless. The two genes are clustered on human chromosome 14q11-13.
Wiese
S
S
Institut für Humangenetik, Göttingen, Germany.
Murphy
D B
DB
Schlung
A
A
Burfeind
P
P
Schmundt
D
D
Schnülle
V
V
Mattei
M G
MG
Thies
U
U
D000595:Amino Acid Sequence; D001483:Base Sequence; D002883:Chromosomes, Human, Pair 14 / Q000737:chemistry*; D004268:DNA-Binding Proteins / Q000235:genetics*; D051858:Forkhead Transcription Factors; D006801:Humans; D008969:Molecular Sequence Data; D005810:Multigene Family; D009419:Nerve Tissue Proteins / Q000235:genetics*; D016415:Sequence Alignment; D013687:Telencephalon / Q000737:chemistry*
D004268:DNA-Binding Proteins; C090173:FOXG1 protein, human; D051858:Forkhead Transcription Factors; D009419:Nerve Tissue Proteins