Twelve-month follow-up study of regional cerebral blood flow in Parkinson's disease.
Measurement of regional cerebral blood flow (rCBF) in 30 patients with Parkinson's disease using single-photon emission computed tomography and 123I-IMP demonstrated that hypoperfusion was relatively severer in the parietal cortex than other cortices before and after a 1-year follow-up period. The decline in the scores of the Mini-Mental State Examination was significantly correlated with the decrease in rCBF in the parietal cortex during the follow-up period. Our findings suggest that the parietal cortex is involved in the cognitive impairment in patients with Parkinson's disease.
Tachibana
H
H
Fifth Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan.
Tomino
Y
Y
Kawabata
K
K
Sugita
M
M
Fukuchi
M
M
D000368:Aged; D001921:Brain / Q000503:physiopathology; D002560:Cerebrovascular Circulation; D005260:Female; D005500:Follow-Up Studies; D005625:Frontal Lobe / Q000098:blood supply; D006801:Humans; D008297:Male; D008875:Middle Aged; D010300:Parkinson Disease / Q000503:physiopathology*; D011569:Psychiatric Status Rating Scales; D013702:Temporal Lobe / Q000098:blood supply