Insulin resistance rather than hyperinsulinemia more closely associated with essential hypertension.
In order to clarify which of the two, insulin resistance or hyperinsulinemia, are more contributable to non obese and non diabetic hypertension, insulin sensitivity test was performed. By multiple regression analysis, mean, systolic, and diastolic blood pressure were inversely correlated with glucose clearance. During insulin sensitivity test, plasma catecholamines levels and FENa were not changed by insulin infusion. In the present study, it is demonstrated that insulin has no hypertensive effect under the mild hyperinsulinemia (45-55 microU/ml). We conclude that insulin resistance rather than hyperinsulinemia may be more closely associated with non obese and non diabetic hypertension.
Yokota
C
C
Department of Medicine, National Cardiovascular Center, Osaka, Japan.
Ikebuchi
M
M
Suzuki
M
M
Norioka
M
M
Ikeda
K
K
Shinozaki
K
K
Harano
Y
Y
D000704:Analysis of Variance; D001786:Blood Glucose / Q000378:metabolism; D001794:Blood Pressure / Q000502:physiology; D002395:Catecholamines / Q000097:blood; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood*; D006973:Hypertension / Q000097:blood / Q000503:physiopathology*; D007333:Insulin Resistance / Q000502:physiology*; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay; D012044:Regression Analysis; D012964:Sodium / Q000378:metabolism; D013050:Spectrometry, Fluorescence
D001786:Blood Glucose; D002395:Catecholamines; D012964:Sodium