Molecular evidence links lymphomatous polyposis of the gastrointestinal tract with mantle cell lymphoma.
Lymphomatous polyposis (LP) is a subtype of non-Hodgkin's lymphoma manifested by numerous polyps affecting long segments of the gastrointestinal tract. The malignant cells of LP often share morphological and immunophenotypic similarity with cells of nodal-based mantle cell lymphoma. Recent genetic studies have shown that mantle cell lymphomas frequently possess a characteristic translocation of the JH/bcl-1 loci. In this study, polymerase chain reaction (PCR) and Southern blot analysis were used to show the presence of JH/bcl-1 translocation in a typical case of LP of the gastrointestinal tract. This provides strong molecular evidence for a biologic link between LP and mantle cell lymphoma. The findings also imply that detection of this translocation may be useful in the diagnosis of morphologically equivocal gastrointestinal biopsy specimens.
Smir
B N
BN
Department of Pathology, University of Texas Health Science Center at San Antonio 78284-7750, USA.
Ramaika
C A
CA
Cho
C G
CG
Gulley
M L
ML
D001483:Base Sequence; D001706:Biopsy; D015139:Blotting, Southern; D019938:Cyclin D1; D017931:DNA Primers / Q000737:chemistry; D015342:DNA Probes / Q000032:analysis / Q000737:chemistry / Q000235:genetics; D004273:DNA, Neoplasm / Q000032:analysis / Q000737:chemistry / Q000235:genetics; D005770:Gastrointestinal Neoplasms / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D016130:Immunophenotyping; D008198:Lymph Nodes / Q000473:pathology; D008228:Lymphoma, Non-Hodgkin / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D008297:Male; D008875:Middle Aged; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011127:Polyps / Q000175:diagnosis / Q000235:genetics* / Q000473:pathology; D011518:Proto-Oncogene Proteins / Q000235:genetics; D014178:Translocation, Genetic
D017931:DNA Primers; D015342:DNA Probes; D004273:DNA, Neoplasm; D007143:Immunoglobulin Heavy Chains; D011518:Proto-Oncogene Proteins; D019938:Cyclin D1