[Anemia in AIDS: the problem to avoid. Human recombinant erythropoietin in the treatment of HIV positive patients].
The most common hematological abnormality associated with HIV infection is anaemia. The aetiology is multifactorial and may include the HIV virus itself; the anaemia of chronic diseases (ACD); infection with other viruses, mycobacteria and fungi; medications, especially zidovudine; and even B12 deficiency. Erythropoietin insufficiency is present in all anaemic AIDS patients, probably as a result of the mechanism of ACD. The studies, performed in patients with PGL, ARC and AIDS stages of disease demonstrate that rHuEPO is safe, and in dose of 100-200 U/kg b.w. three times a week can alleviate the anemia in AIDS patients taking AZT whose baseline EPO levels are less than 500 mU/ml.
Karwacki
M
M
Klinika Hematologii i Chorób Rozrostowych Dzieci AM w Warszawie.
Ochocka
M
M
Kubiak
W
W
D000163:Acquired Immunodeficiency Syndrome / Q000150:complications* / Q000188:drug therapy; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology*; D002908:Chronic Disease; D004921:Erythropoietin / Q000172:deficiency* / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D015215:Zidovudine / Q000494:pharmacology / Q000627:therapeutic use
D004921:Erythropoietin; D015215:Zidovudine