B-lymphocyte requirement for vaccine-mediated protection from Theiler's murine encephalomyelitis virus-induced central nervous system disease.
The role of humoral immunity in the protection of vaccinated SJL/J mice from central nervous system disease induced by the DA strain (DAV) of Theiler's murine encephalomyelitis virus was investigated in B-cell-deficient mice. Mice were depleted of B cells by treatment with a mouse monoclonal antibody specific for immunoglobulin M. DAV-vaccinated, B-cell-deficient mice failed to clear viral infection and were no longer protected from Theiler's murine encephalomyelitis virus-mediated central nervous system disease. CD4+ T cells are required in this model of protection to provide help for the development of an antiviral antibody response in the central nervous system.
Kurtz
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CI
Department of Neurology, University of Utah School of Medicine, Salt Lake City 84132, USA.
Sun
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XM
Fujinami
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RS
D000818:Animals; D001402:B-Lymphocytes / Q000166:cytology / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D007111:Immunity, Cellular; D008212:Lymphocyte Depletion; D051379:Mice; D011051:Poliomyelitis / Q000276:immunology / Q000517:prevention & control* / Q000821:virology; D017945:Theilovirus / Q000276:immunology*; D014765:Viral Vaccines / Q000276:immunology*
D014765:Viral Vaccines