A Xenopus c-kit-related receptor tyrosine kinase expressed in migrating stem cells of the lateral line system.
The mammalian c-kit receptor tyrosine kinase gene is required during embryogenesis for the survival and/or proliferation of three migrating stem cell populations: primordial germ cells, haematopoietic stem cells and neural crest-derived melanoblasts. We have cloned a Xenopus gene, XKrk1, whose closest relative is c-kit. Differences in the expression pattern suggest that XKrk1 is not the Xenopus homologue of c-kit; however, it is expressed in a migrating stem cell population, the precursor cells for the mechanosensory lateral line system. XKrk1 is the first reported marker for lateral line stem cells.
Baker
C V
CV
Wellcome/CRC Institute, University of Cambridge, UK.
Sharpe
C R
CR
Torpey
N P
NP
Heasman
J
J
Wylie
C C
CC
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002465:Cell Movement; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D008465:Mechanoreceptors / Q000196:embryology*; D008969:Molecular Sequence Data; D020794:Receptor Protein-Tyrosine Kinases / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D013234:Stem Cells / Q000166:cytology*; D014981:Xenopus
D020794:Receptor Protein-Tyrosine Kinases