Histidine ameliorated brain edema and cardiac dysfunction during local thrombotic cerebral ischemia in rats.
OBJECTIVE
To observe the effects of histidine (i.v. 5 mg.kg-1) on brain edema and cardiac disturbance after cerebral thrombosis.


METHODS
Regional cerebral thrombosis was induced by photochemical method in rats.


RESULTS
It was showed that the brain water content increased markedly (85.6 +/- 3.8%, P < 0.01); the left ventricular systolic pressure (LVSP, 17.9 +/- 1.5 kPa) and the maximal left ventricular contractility decreased (+dp/dtmax 645 +/- 110 kPa and -dp/dtmax 473 +/- 106 kPa, P < 0.05). In rats treated with histidine after photochemical reaction, the brain water content decreased (81.5 +/- 2.0%) while LVSP (21.2 +/- 1.1 kPa) and left ventricular +dp/dtmax and -dp/dtmax increased markedly (777 +/- 144 kPa and 604 +/- 157 kPa, respectively).


CONCLUSIONS
Histidine has protective effects on the brain and cardiac function during cerebral thrombosis.
Li
S Q
SQ
Department of Pathophysiology, Kunming Medical College, China.
Han
H
H
He
J
J
D000818:Animals; D001929:Brain Edema / Q000188:drug therapy* / Q000209:etiology; D006639:Histidine / Q000627:therapeutic use*; D002542:Intracranial Embolism and Thrombosis / Q000150:complications*; D008297:Male; D009200:Myocardial Contraction / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D016277:Ventricular Function, Left / Q000187:drug effects
D006639:Histidine