Genetic susceptibility biomarkers in studies of occupational and environmental cancer: methodologic issues.
When using biomarkers to assess genetic susceptibility for cancer risk, the following issues should be recognized: (i) exposure assessment should receive as much attention as marker measurement; (ii) it is critical to study cases with a wide range of exposure patterns; (iii) each approach to evaluating susceptibility has its own potential biases; (iv) it is important to demonstrate the biologic plausibility of gene-exposure interactions detected in epidemiologic studies.
Rothman
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Occupational Studies Section, NIH/NCI EPN 418, Bethesda, MD 20892, USA.
D015415:Biomarkers / Q000032:analysis*; D004785:Environmental Pollutants / Q000009:adverse effects*; D020022:Genetic Predisposition to Disease; D006801:Humans; D009369:Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000235:genetics; D016273:Occupational Exposure / Q000009:adverse effects*; D014116:Toxicology / Q000379:methods
D015415:Biomarkers; D004785:Environmental Pollutants