title: History of thyroid diseases and subsequent thyroid cancer risk.
abstract: A history of benign thyroid diseases has been associated with the risk of thyroid cancer. We have analyzed this issue using data from a case-control study conducted in northern Italy between 1986 and 1992 on 399 incident, histologically confirmed thyroid cancer cases and 617 controls admitted to the hospital for acute, nonneoplastic, non-hormone-related diseases. The overall multivariate relative risk (RR) estimates were 2.8 [95% confidence interval (CI), 0.6-12.4] for previous episodes of thyroiditis, 27.1 (95% CI, 6.5-111.9) for adenoma, 8.2 (95% CI, 3.5-19.1) for goiter, 3.8 (95% CI, 1.4-10.9) for hyperthyroidism, and 1.5 (95% CI, 0.4-5.1) for hypothyroidism when all histotypes were analyzed. The RR for any thyroid disease was 7.7 (95% CI, 4.6-12.8). A family history of thyroid disease was significantly related to thyroid cancer with an RR of 1.6. The RR for having resided in endemic goiter areas was 1.3 for < 20 years of residence and 1.6 for 20 or more years. These associations were somewhat stronger when only papillary, follicular, and mixed papillary/follicular cancers were considered. Analyses of data in separate strata of sex and age suggested that several benign conditions play a more important role in females and in subjects younger than 50 years. Results were similar to the overall ones when papillary and follicular carcinomas were considered separately. The population-attributable risk for any previous thyroid disease was approximately 20% in this Italian population. These results confirm that history of thyroid disease is a relevant indicator of subsequent thyroid cancer risk also in areas at relatively low prevalence of goiter and other thyroid diseases.
authors.affiliation: Istituto di Ricerche Farmacologiche, Mario Negri, Milan, Italy.
authors.forename: B
authors.initials: B
authors.lastname: D'Avanzo
authors.forename: C
authors.initials: C
authors.lastname: La Vecchia
authors.forename: S
authors.initials: S
authors.lastname: Franceschi
authors.forename: E
authors.initials: E
authors.lastname: Negri
authors.forename: R
authors.initials: R
authors.lastname: Talamini
mesh_terms: D018263:Adenocarcinoma, Follicular / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D000293:Adolescent; D000328:Adult; D000368:Aged; D002291:Carcinoma, Papillary / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D018265:Carcinoma, Papillary, Follicular / Q000453:epidemiology / Q000209:etiology / Q000473:pathology; D016022:Case-Control Studies; D016001:Confidence Intervals; D005260:Female; D006043:Goiter, Endemic / Q000150:complications / Q000453:epidemiology / Q000473:pathology; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D013959:Thyroid Diseases / Q000150:complications* / Q000453:epidemiology / Q000473:pathology; D013961:Thyroid Gland / Q000473:pathology; D013964:Thyroid Neoplasms / Q000453:epidemiology / Q000209:etiology* / Q000473:pathology