title: Human papillomavirus type 18 DNA in gestational trophoblastic tissues and choriocarcinomas.
abstract: The objectives of our study were to better understand carcinogenesis of gestational trophoblastic tumors and to investigate the possible presence of human papillomavirus types 16 and 18 DNA sequences in these tumors. Amplification-based DNA methodology was used on 11 hydatidiform moles, 5 invasive moles, 8 choriocarcinomas and 9 normal early placental tissues. Human papillomavirus type 16 DNA was not found in any of these tissues. Although human papillomavirus type 18 DNA was also not found in the 9 normal placentas and 5 invasive moles, it was present in 2 of the 11 (18%) hydatidiform moles and in 4 of the 8 (50%) choriocarcinomas.
authors.affiliation: Department of Biochemistry, Chang Gung College of Medicine and Technology, Taipei, Taiwan, China.
authors.forename: C C
authors.initials: CC
authors.lastname: Pao
authors.forename: J J
authors.initials: JJ
authors.lastname: Hor
authors.forename: C J
authors.initials: CJ
authors.lastname: Wu
authors.forename: Y F
authors.initials: YF
authors.lastname: Shi
authors.forename: X
authors.initials: X
authors.lastname: Xie
authors.forename: S M
authors.initials: SM
authors.lastname: Lu
mesh_terms: D001483:Base Sequence; D002822:Choriocarcinoma / Q000821:virology*; D004279:DNA, Viral / Q000032:analysis / Q000235:genetics*; D004268:DNA-Binding Proteins; D005260:Female; D005784:Gene Amplification; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D009856:Oncogene Proteins, Viral / Q000235:genetics; D027383:Papillomaviridae / Q000235:genetics*; D011247:Pregnancy; D014328:Trophoblastic Neoplasms / Q000821:virology*; D014327:Trophoblasts / Q000821:virology*; D014594:Uterine Neoplasms / Q000821:virology*
chemical_list: D004279:DNA, Viral; D004268:DNA-Binding Proteins; C052603:E6 protein, Human papillomavirus type 18; C052633:E7 protein, Human papillomavirus type 18; D009856:Oncogene Proteins, Viral