title: Increased incidence of cutaneous carcinomas in patients with congenital ichthyosis.
abstract: It is well known that patients with heritable cutaneous diseases may have excess tumors during their lifetime. This relationship has been shown for such diverse conditions as xeroderma pigmentosum, Bloom syndrome, basal cell nevus syndrome, and psoriasis. However, multiple cutaneous tumors have not been previously described in people with lamellar ichthyosis. This article describes the cases of two such patients, possible treatment, and a previously undescribed ichthyosis syndrome.
authors.affiliation: Kern Dermatology Medical Group, Inc., Bakersfield, CA, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Elbaum
authors.forename: G
authors.initials: G
authors.lastname: Kurz
authors.forename: M
authors.initials: M
authors.lastname: MacDuff
mesh_terms: D000293:Adolescent; D000328:Adult; D001706:Biopsy; D002280:Basal Cell Carcinoma / Q000209:etiology / Q000473:pathology; D002294:Carcinoma, Squamous Cell / Q000209:etiology* / Q000473:pathology; D005050:Etretinate / Q000627:therapeutic use; D006801:Humans; D007057:Ichthyosis / Q000150:complications*; D015474:Isotretinoin / Q000627:therapeutic use; D008297:Male; D016609:Neoplasms, Second Primary / Q000209:etiology / Q000473:pathology; D012535:Scalp / Q000473:pathology*; D012878:Skin Neoplasms / Q000209:etiology* / Q000473:pathology
chemical_list: D005050:Etretinate; D015474:Isotretinoin