title: Factors related to the incidence and severity of cyclosporin-induced gingival overgrowth in transplant patients. A longitudinal study.
abstract: A longitudinal study was conducted during the first 6 months following transplant surgery in 100 heart, liver, or kidney transplant patients to assess the incidence and severity of cyclosporin-induced gingival overgrowth, as well as the most important associated factors. Gingival overgrowth, plaque, and gingivitis indices, in addition to cyclosporin blood concentration, were assessed monthly. Statistical analysis was applied to evaluate the relationship between gingival overgrowth and other study variables and to test the influence of age, sex, time, and transplant type. Forty-three percent (43%) of the patients developed gingival overgrowth. Gingival overgrowth increased significantly during the study, while plaque and gingivitis, subject to an oral hygiene training and motivation program, decreased significantly. The findings from this study would suggest that the basic factor influencing gingival overgrowth is cyclosporin blood concentration, followed by plaque/gingivitis level. The significant differences observed among transplant types, as well as among age groups, might be attributed to the differences in cyclosporin concentrations. An oral hygiene program prior to the transplant surgery is recommended.
authors.affiliation: Complutense University, Faculty of Dentistry, Department of Oral Medicine and Surgery, Madrid, Spain.
authors.forename: M L
authors.initials: ML
authors.lastname: Somacarrera
authors.forename: G
authors.initials: G
authors.lastname: Hernández
authors.forename: J
authors.initials: J
authors.lastname: Acero
authors.forename: B S
authors.initials: BS
authors.lastname: Moskow
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002648:Child; D016572:Cyclosporine / Q000009:adverse effects* / Q000097:blood; D003773:Dental Plaque / Q000150:complications; D003774:Dental Plaque Index; D004305:Dose-Response Relationship, Drug; D005260:Female; D005885:Gingival Hyperplasia / Q000139:chemically induced* / Q000150:complications / Q000473:pathology; D005891:Gingivitis / Q000150:complications; D016027:Heart Transplantation; D006801:Humans; D015994:Incidence; D016030:Kidney Transplantation; D016031:Liver Transplantation; D008137:Longitudinal Studies; D008297:Male; D008875:Middle Aged; D009911:Oral Hygiene Index; D016377:Organ Transplantation; D010512:Periodontal Index; D012044:Regression Analysis; D018709:Statistics, Nonparametric
chemical_list: D016572:Cyclosporine