Effects of cyclosporine A on experimental hepatic metastases of mouse colon-26 tumour.
Cyclosporine A (CSA), an immunosuppressive agent with apparently selective effects on T lymphocytes and little myelotoxicity, was tested for its effects on hepatic metastases by inoculation of mouse colon-26 tumour cells into the portal vein in male CDF1 mice. CSA, given subcutaneously in daily doses of 10-50 mg/kg/day, for 22 days, significantly increased the incidence of hepatic nodules. This increase was positively correlated with the CSA dose. When 5-fluorouracil was injected at a dose of 15 mg/kg/day every other day after the inoculation of tumour cells a highly significant reduction in the incidence of metastases was seen (compared with the controls). This strong inhibitory effect of 5-fluorouracil on metastasis was almost completely suppressed when mice were treated with CSA concomitantly. The results suggest that CSA affects the host immune system, accelerating the production of hepatic metastases.
Suzaki
N
N
First Department of Surgery, Okayama University Medical School, Japan.
Fuchimoto
S
S
Iwagaki
H
H
Orita
K
K
D000230:Adenocarcinoma / Q000473:pathology / Q000556:secondary*; D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D003110:Colonic Neoplasms / Q000473:pathology*; D016572:Cyclosporine / Q000037:antagonists & inhibitors / Q000627:therapeutic use*; D005472:Fluorouracil / Q000494:pharmacology; D007275:Injections, Intravenous; D008114:Liver Neoplasms, Experimental / Q000188:drug therapy* / Q000556:secondary; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation; D011169:Portal Vein; D013601:T-Lymphocytes / Q000187:drug effects; D014407:Tumor Cells, Cultured
D016572:Cyclosporine; D005472:Fluorouracil