title: Aminosidine sulphate in experimental giardiasis.
abstract: Giardia lamblia infection may be asymptomatic or may produce diarrhea with or without malabsorption. Many drugs were used for treatment of giardiasis, but none proved to be ideal since all have potential troublesome side effects as they are absorbed from the intestine. In this study, a locally acting drug aminosidine-sulphate (gabbroral) has been tried in treatment of experimental giardiasis in a rat model under different conditions of gastric acidity which is one of the main local factors affecting the pathogenicity of the organism. The best results were obtained in the group with hyperacidity which was induced by indomethacin (indocid) with significant improvement in the pathological picture and parasitic count. While in experimental animals with normal acidity there was only partial eradication of the parasite. However, in the group with hypoacidity induced by cimetidine (cimetex), the drug showed no beneficial effects since most organisms invaded the deeper layers of the intestine escaping the local action of the drug.
authors.affiliation: Department of Parasitology, Faculty of Medicine, Alexandria University, Egypt.
authors.forename: H N
authors.initials: HN
authors.lastname: Awadalla
authors.forename: S H
authors.initials: SH
authors.lastname: el-Gowhary
authors.forename: H A
authors.initials: HA
authors.lastname: Sadaka
authors.forename: A M
authors.initials: AM
authors.lastname: Khalifa
mesh_terms: D000818:Animals; D000981:Antiprotozoal Agents / Q000627:therapeutic use; D002927:Cimetidine / Q000494:pharmacology; D005744:Gastric Acid / Q000378:metabolism; D016829:Giardia lamblia / Q000187:drug effects* / Q000254:growth & development; D005873:Giardiasis / Q000188:drug therapy* / Q000469:parasitology / Q000473:pathology; D007213:Indomethacin / Q000494:pharmacology; D007421:Intestine, Small / Q000469:parasitology / Q000473:pathology; D010270:Parasite Egg Count; D010303:Paromomycin / Q000627:therapeutic use*; D051381:Rats
chemical_list: D000981:Antiprotozoal Agents; D010303:Paromomycin; D002927:Cimetidine; D007213:Indomethacin