title: Synthetic approaches to some new sulfur-containing heterocycles of anticipated immunosuppressive activity.
abstract: Several new isolated or fused heterocyclic ring systems that accomodate the isothioureido functionality, often associated with immunosuppressive activity, were synthesized for possible use as immunosuppressive agents. Preparation of these anchored heterocycles was achieved via a multi-step synthesis starting with the key intermediate thiazolyl thiourea derivative (I). Structure of the newly synthesized products was confirmed using both of elemental and spectral analyses.
authors.affiliation: Chemistry Department, Mansoura University, Egypt.
authors.forename: M M
authors.initials: MM
authors.lastname: Girges
authors.forename: M A
authors.initials: MA
authors.lastname: Hanna
authors.forename: S N
authors.initials: SN
authors.lastname: Ayyad
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000494:pharmacology; D006968:Hypersensitivity, Delayed / Q000188:drug therapy; D007166:Immunosuppressive Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D051379:Mice; D013455:Sulfur / Q000737:chemistry
chemical_list: D000900:Anti-Bacterial Agents; D006571:Heterocyclic Compounds; D007166:Immunosuppressive Agents; D013455:Sulfur