Local recurrence of rectal cancer following preoperative irradiation.
The authors investigated local recurrence of rectal cancer in patients' groups preoperatively irradiated (40-50 Gy) or treated by surgery alone. In advanced disease both treatment groups were administered postoperative chemotherapy, too. Local recurrence was observed in 30.2% in patients treated by surgery alone, while it dropped to 11.65% in the patients' group subjected to radiation therapy prior to surgery (p < 0.05). Impairment of degree of differentiation resulted in an enhanced number of recurrences in both groups, even if they appeared later in irradiated patients.
Illényi
L
L
1st Department of Surgery, University Medical School, Hungary.
Grexa
E
E
Gecser
G
G
Kött
I
I
D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D017024:Chemotherapy, Adjuvant; D003037:Cobalt Radioisotopes / Q000627:therapeutic use; D003131:Combined Modality Therapy; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000209:etiology*; D009367:Neoplasm Staging; D011300:Preoperative Care; D011446:Prospective Studies; D018714:Radiotherapy, Adjuvant; D012004:Rectal Neoplasms / Q000188:drug therapy / Q000532:radiotherapy* / Q000601:surgery*
D003037:Cobalt Radioisotopes