Trisomy 20 is a primary chromosome aberration in desmoid tumors.
Cytogenetic analysis revealed trisomy 20 in 4 desmoid tumors: in 2 cases as the sole aberration, in 1 together with +X, -Y and -13 and in 1 with +8 and a supernumerary marker chromosome. Our findings indicate that gain of chromosome 20 is an early event in the development of a large subset of desmoid tumors and that it is as frequent as +8, the only consistent chromosomal change previously reported in this tumor type. The non-random occurrence of trisomies 8 and 20 in desmoid tumors indicates shared pathogenetic mechanisms with infantile fibrosarcoma, a fibrous tissue tumor characterized by various combinations of trisomies for chromosomes 8, 11, 17 and 20.
Mertens
F
F
Department of Clinical Genetics, University Hospital, Lund, Sweden.
Willén
H
H
Rydholm
A
A
Brosjö
O
O
Carlén
B
B
Mitelman
F
F
Mandahl
N
N
D000328:Adult; D000368:Aged; D002890:Chromosomes, Human, Pair 20 / Q000235:genetics*; D005260:Female; D018222:Desmoid Tumors / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014314:Trisomy / Q000235:genetics*