title: C3.SW-Soaa heterozygous congenic taster mice.
abstract: Sensitivity to the bitter acetylated sugar sucrose octaacetate (SOA) is mediated by a single-locus system with three alleles in mice. Inbred strains are classified according to SOA phenotype as tasters, nontasters, or demitasters (intermediate sensitivity). A congenic quartet created from taster and nontaster strains has been used to investigate the effect of the Soa locus on non-SOA aspects of taste sensitivity. In this study, we created a third congenic set, C3.SW-Soaa, from taster (SWR/J) and demitaster (C3HeB/FeJ) strains. After 11 lineal backcross generations these C3.SW mice carry the tasting allele on a 99% C3 demitaster background. After testing a total of 938 mice, taster-demitaster proportions across 12 generations were consistent with expectations from a monogenic model. The resultant three-strain congenic series will allow further examination of the mechanisms of taste.
authors.affiliation: Department of Psychology, Florida State University, Tallahassee 32306-1051, USA.
authors.forename: J D
authors.initials: JD
authors.lastname: Boughter
authors.forename: G
authors.initials: G
authors.lastname: Whitney
mesh_terms: D000483:Alleles; D000818:Animals; D002874:Chromosome Mapping; D003433:Crosses, Genetic; D005260:Female; D005518:Food Preferences; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H / Q000235:genetics; D008815:Mice, Inbred Strains / Q000235:genetics*; D010375:Pedigree; D010641:Phenotype; D013395:Sucrose / Q000031:analogs & derivatives*; D013649:Taste / Q000235:genetics*; D013652:Taste Threshold
chemical_list: C026879:sucrose octaacetate; D013395:Sucrose