Chromosomal localization of the genes for five zinc finger proteins expressed in mouse lens.
Based on sequence similarity to a consensus zinc finger domain, we have identified cDNAs encoding five proteins containing zinc finger nucleic acid binding motifs from a newborn mouse lens library. Utilizing these cDNAs as hybridization probes, we have mapped two of the corresponding genes to mouse Chr (chromosome) 11, two to mouse Chr 7, and one to mouse Chr 4 using two multilocus crosses. Because the zinc finger proteins encoded by these genes may be involved in regulating other genes that are expressed in lens, they can be considered candidates for the large number of yet unmapped cataract loci.
Danciger
M
M
Jules Stein Eye Institute, UCLA School of Medicine 90024-7008, USA.
Brady
J
J
Adamson
M C
MC
Farber
D B
DB
Piatigorsky
J
J
Kozak
C A
CA
D000818:Animals; D002874:Chromosome Mapping; D018076:DNA, Complementary / Q000235:genetics / Q000302:isolation & purification; D007908:Lens, Crystalline / Q000648:ultrastructure*; D051379:Mice; D008969:Molecular Sequence Data; D017421:Sequence Analysis; D016335:Zinc Fingers / Q000235:genetics*
D018076:DNA, Complementary