Effects of treatment with simvastatin and pravastatin on cognitive function in patients with hypercholesterolaemia.
The effects of equi-efficacious doses of the cholesterol-lowering drugs simvastatin (20 mg day-1) and pravastatin (40 mg day-1) on tests of cognitive function were investigated in a double-blind, placebo-controlled, 2-period (4 weeks per period), incomplete block, crossover study of 36 patients (24 per treatment) with hypercholesterolaemia. After 4 weeks neither of the active treatments differed significantly from placebo on any cognitive measure.
Cutler
N
N
California Clinical Trials, Beverly Hills 90211, USA.
Sramek
J
J
Veroff
A
A
Block
G
G
Stauffer
L
L
Lines
C
C
D000328:Adult; D000924:Anticholesteremic Agents / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D003071:Cognition / Q000187:drug effects*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006937:Hypercholesterolemia / Q000188:drug therapy*; D008055:Lipids / Q000097:blood; D008148:Lovastatin / Q000008:administration & dosage / Q000009:adverse effects / Q000031:analogs & derivatives* / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D017035:Pravastatin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use; D019821:Simvastatin
D000924:Anticholesteremic Agents; D008055:Lipids; D008148:Lovastatin; D019821:Simvastatin; D017035:Pravastatin