Proinflammatory cytokines as pathogenetic mediators in the central nervous system: brain-periphery connections.
Cytokines can be produced within the brain and are implicated as pathogenetic mediators of pathologies of the central nervous system (CNS). They cause various CNS effects, inducing fever, anorexia, sleepiness and activating the hypothalamus-pituitary-adrenal axis. Centrally administered cytokines cause peripheral effects such as induction of the synthesis of hepatic acute-phase proteins (APP). Some of their effects (e.g. anorexia, APP synthesis, fever) may result from both central and peripheral actions. Some represent feedback mechanisms that inhibit excess cytokine production.
Faggioni
R
R
Laboratory of Neuroimmunology, Mario Negri Institute for Pharmacological Research, Milano, Italy.
Benigni
F
F
Ghezzi
P
P
D000818:Animals; D000855:Anorexia / Q000139:chemically induced; D001921:Brain / Q000187:drug effects / Q000502:physiology; D002490:Central Nervous System / Q000187:drug effects / Q000502:physiology*; D016207:Cytokines / Q000494:pharmacology / Q000502:physiology*; D005334:Fever / Q000139:chemically induced; D007030:Hypothalamo-Hypophyseal System / Q000187:drug effects; D007249:Inflammation / Q000503:physiopathology; D007378:Interleukins / Q000494:pharmacology / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000187:drug effects; D011453:Prostaglandins / Q000494:pharmacology; D018121:Receptors, Cytokine / Q000502:physiology; D014409:Tumor Necrosis Factor-alpha / Q000502:physiology
D016207:Cytokines; D007378:Interleukins; D011453:Prostaglandins; D018121:Receptors, Cytokine; D014409:Tumor Necrosis Factor-alpha