title: Clinical and ultrastructural comparison of immunohistochemically inactive and gonadotropin-producing pituitary adenomas.
abstract: A clinicoendocrinological and ultrastructural comparison of immunohistochemically inactive pituitary adenomas from 14 patients and gonadotropin-positive pituitary adenomas from 26 patients was carried out. Clinicoendocrinological characteristics were similar except the male to female ratios. The immunohistochemically unstable antigenicity of gonadotropin prevents clear immunohistochemical characterization, but the difference between the two types is not absolute and may be an indication of a cell line relationship.
authors.affiliation: Department of Neurosurgery, Tachikawa Kyosai Hospital, Tokyo.
authors.forename: S
authors.initials: S
authors.lastname: Furuhata
authors.forename: T
authors.initials: T
authors.lastname: Kameya
authors.forename: T
authors.initials: T
authors.lastname: Tsuruta
authors.forename: H
authors.initials: H
authors.lastname: Naritaka
mesh_terms: D000236:Adenoma / Q000473:pathology* / Q000648:ultrastructure*; D000328:Adult; D046508:Culture Techniques; D005260:Female; D006062:Gonadotropins / Q000032:analysis* / Q000378:metabolism*; D006801:Humans; D007150:Immunohistochemistry; D008215:Lymphocytes, Null; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000473:pathology* / Q000648:ultrastructure*; D010911:Pituitary Neoplasms / Q000473:pathology* / Q000648:ultrastructure*
chemical_list: D006062:Gonadotropins