Is rotavirus a population of reassortants?
Rotaviruses appear to exist as heterogeneous populations of reassortants and related variants. This phenomenon is consistent with the quasispecies concept of RNA viruses, and suggests that gene reassortment is a crucial evolutionary mechanism for this segmented virus. It also explains puzzling epidemiological findings and controversial results of vaccine-efficacy studies.
Gouvea
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V
Human Genetics Branch, National Institutes of Health, Bethesda, MD 20892, USA.
Brantly
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M
D000818:Animals; D005075:Biological Evolution; D006801:Humans; D016865:Reassortant Viruses; D012401:Rotavirus / Q000235:genetics; D014765:Viral Vaccines
D014765:Viral Vaccines