title: Hyperprolactinemia after treatment of long-acting gonadotropin-releasing hormone analogue Decapeptyl in girls with central precocious puberty.
abstract: OBJECTIVE
  To clarify the effects of prolonged treatment with long-acting GnRH analogue on serum PRL levels.
  
  
  METHODS
  Blood PRL levels were measured at 9 A.M. every 28 days for a period of 6 months.
  
  
  METHODS
  Pediatric Endocrine Clinic, Hasharon Hospital, Petah Tiqva, Israel.
  
  
  METHODS
  Thirteen girls with idiopathic central precocious puberty.
  
  
  RESULTS
  Hyperprolactinemia developed in 5 of 13 girls after treatment with long-acting GnRH-a; mean blood PRL in all 13 girls rose significantly from 11.9 +/- 5.6 to 21.5 +/- 12.5 micrograms/L (mean +/- SD).
  
  
  CONCLUSIONS
  The mechanism of hyperprolactinemia in our patients is unclear. It may have resulted from a decline in the release of the hypothalamic PRL inhibitory factor. Clinically, transient hyperprolactinemia during long-acting GnRH-a treatment for central precocious puberty also may reflect a constant depression of LH secretion.
authors.affiliation: Department of Obstetrics and Gynecology, Hasharon Hospital, Petah Tiqva, Israel.
authors.forename: A
authors.initials: A
authors.lastname: Kauschansky
authors.forename: M
authors.initials: M
authors.lastname: Nussinovitch
authors.forename: M
authors.initials: M
authors.lastname: Frydman
authors.forename: A
authors.initials: A
authors.lastname: Yeshaya
authors.forename: Z
authors.initials: Z
authors.lastname: Ben-Rafael
mesh_terms: D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000139:chemically induced*; D007223:Infant; D011629:Puberty, Precocious / Q000188:drug therapy*; D017329:Triptorelin Pamoate / Q000009:adverse effects*
chemical_list: D017329:Triptorelin Pamoate