Apolipoprotein E alleles but neither apolipoprotein B nor apolipoprotein AI/CIII alleles are associated with late onset, familial Alzheimer's disease.
The possibility of a genetic association between late onset, familial Alzheimer's disease and alleles at the apolipoprotein B and AI/CIII loci have been examined. In contrast to the genetic association with the apolipoprotein E locus, no evidence for genetic associations to these loci was found.
Houlden
H
H
Suncoast Alzheimer's Disease Labs., Departments of Psychiatry, Pharmacology, Neurology and Biochemistry, University of South Florida, Tampa 33613, USA.
Crook
R
R
Duff
K
K
Hutton
M
M
Collinge
J
J
Roques
P
P
Rossor
M
M
Hardy
J
J
D017668:Age of Onset; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D016632:Apolipoprotein A-I / Q000235:genetics*; D001055:Apolipoproteins B / Q000235:genetics*; D001056:Apolipoproteins C / Q000235:genetics*; D001057:Apolipoproteins E / Q000235:genetics*; D004247:DNA / Q000097:blood; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction; D012150:Polymorphism, Restriction Fragment Length
D016632:Apolipoprotein A-I; D001055:Apolipoproteins B; D001056:Apolipoproteins C; D001057:Apolipoproteins E; D004247:DNA