title: Bile acid absorption from ileoanal pouches using enema scintigraphy.
abstract: It is unclear whether bile acid absorption is affected by ileoanal pouch construction. Bile acid absorption was measured in the abdomen of 16 patients with pouches (nine with good and seven with poor pouch function based on a clinical score) and in six patients with an end ileostomy using a radiolabelled synthetic bile acid (75SeHCAT) enema and dynamic scintigraphy. The median (interquartile range) 75SeHCAT absorption was 81 (79-87) per cent in patients with ileostomy, 46 (43-53) per cent in patients having well functioning pouches, and 24 (18-38) per cent in the group with poor pouch function (P < 0.01). Log transformation of the absorption curves revealed a two-component uptake (fast component t1/2 = 1.4-7.2 min; slow component t1/2 = 16-144 min) in all patients with ileostomy, in eight of nine patients with pouches with good function, and in one of seven patients with a poorly functioning pouch (P < 0.05); in the other six patients with poorly functioning pouches, only the slow component of absorption was present. This test showed significantly reduced bile acid absorption in patients with an ileoanal pouch and gave an objective discrimination between well and poorly functioning pouches.
authors.affiliation: Academic Department of Surgery, Queen Elizabeth Hospital, Birmingham, UK.
authors.forename: I M
authors.initials: IM
authors.lastname: Bain
authors.forename: A B
authors.initials: AB
authors.lastname: Mostafa
authors.forename: L K
authors.initials: LK
authors.lastname: Harding
authors.forename: J P
authors.initials: JP
authors.lastname: Neoptolemos
authors.forename: M R
authors.initials: MR
authors.lastname: Keighley
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D004733:Enema; D005260:Female; D006801:Humans; D007081:Ileostomy; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D016737:Proctocolectomy, Restorative; D011877:Radionuclide Imaging / Q000379:methods; D012644:Selenium Radioisotopes / Q000378:metabolism*; D013656:Taurocholic Acid / Q000031:analogs & derivatives* / Q000378:metabolism
chemical_list: D012644:Selenium Radioisotopes; D013656:Taurocholic Acid; C033638:23-seleno-25-homotaurocholic acid