Imprecise exposure assessment and the sample size requirements of case-control studies of residential magnetic field exposure and cancer in adults.
A computer program simulating case-control studies is described. It is used to estimate the minimum sample size required and to assess how this is affected by imprecise exposure assessment. In particular, the consequences of neglecting measurements of nonresidential exposure in case-control studies of residentially exposed adults are investigated. According to this model, while the consequent loss of power is not as large as was predicted by algebraic methods, it would be unwise to neglect it when planning a study.
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Australian Radiation Laboratory, Yallambie, Victoria.
D000328:Adult; D000465:Algorithms; D001943:Breast Neoplasms / Q000453:epidemiology; D016022:Case-Control Studies; D003198:Computer Simulation; D004574:Electromagnetic Fields; D004781:Environmental Exposure; D005260:Female; D005544:Forecasting; D006798:Housing; D006801:Humans; D008280:Magnetics; D008954:Models, Biological; D015233:Models, Statistical; D009381:Neoplasms, Radiation-Induced / Q000453:epidemiology*; D012307:Risk Factors; D018401:Sample Size; D012680:Sensitivity and Specificity; D012984:Software; D014739:Victoria / Q000453:epidemiology