Glycinergic inhibition of spontaneously active guinea-pig medial vestibular nucleus neurons in vitro.
Effects of glycine on the spontaneous activity of medial vestibular nucleus (MVN) neurons recorded extracellularly from guinea-pig brainstem slices were investigated. Glycine produced a dose-dependent decrease in the resting discharge rate of all MVN neurons tested, with a mean EC50 of 3.9 x 10(-4) M. The inhibitory effect of glycine was reversibly blocked by strychnine and persisted in a low calcium/high magnesium-containing saline solution. These findings suggest the existence of a direct strychnine-sensitive inhibitory effect of glycine on guinea-pig MVN neurons.
Lapeyre
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PN
Laboratoire de Physiologie de la Perception et de l'Action, Collège de France CNRS, UMR C9950, Paris.
De Waele
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C
D000818:Animals; D002118:Calcium / Q000494:pharmacology; D004594:Electrophysiology; D005998:Glycine / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008274:Magnesium / Q000494:pharmacology; D008297:Male; D009433:Neural Inhibition / Q000502:physiology*; D009474:Neurons / Q000187:drug effects; D017729:Presynaptic Terminals / Q000187:drug effects; D012680:Sensitivity and Specificity; D013331:Strychnine / Q000494:pharmacology; D009435:Synaptic Transmission / Q000187:drug effects; D014726:Vestibular Nuclei / Q000166:cytology / Q000502:physiology*
D013331:Strychnine; D008274:Magnesium; D002118:Calcium; D005998:Glycine