title: Neurologic complications of pediatric liver transplantation.
abstract: The neurologic complications of 24 children, ages 5 months to 18 years, following orthotopic liver transplantation at the Indiana University hospitals are reported. Biliary atresia (14 patients) was the most common cause for orthotopic liver transplantation. Three children died. Seventeen children (70%) had no neurologic deficit on follow-up 6 months or longer after transplantation. Eleven children (46%), including 4 of 16 patients (25%) who had received OKT3, had neurologic complications. Seven children (29%) had new-onset seizures; 4 of these patients had status epilepticus. Two children had intracranial hemorrhage. Seizures occurred later in children than in adults following orthotopic liver transplantation and were not associated with poor prognosis. Longer term follow-up is indicated to assess subtle, cognitive deficits following liver transplantation in children.
authors.affiliation: Department of Neurology, Indiana University Medical Center, Indianapolis, USA.
authors.forename: B P
authors.initials: BP
authors.lastname: Garg
authors.forename: L E
authors.initials: LE
authors.lastname: Walsh
authors.forename: M D
authors.initials: MD
authors.lastname: Pescovitz
authors.forename: H
authors.initials: H
authors.lastname: Patel
authors.forename: S
authors.initials: S
authors.lastname: Chong
authors.forename: R S
authors.initials: RS
authors.lastname: Filo
authors.forename: J
authors.initials: J
authors.lastname: Fitzgerald
mesh_terms: D000293:Adolescent; D001656:Biliary Atresia / Q000503:physiopathology / Q000601:surgery*; D001925:Brain Damage, Chronic / Q000175:diagnosis / Q000503:physiopathology; D002543:Cerebral Hemorrhage / Q000175:diagnosis / Q000503:physiopathology; D002648:Child; D002675:Child, Preschool; D004569:Electroencephalography; D005260:Female; D005500:Follow-Up Studies; D006501:Hepatic Encephalopathy / Q000175:diagnosis* / Q000503:physiopathology; D006801:Humans; D007223:Infant; D008103:Liver Cirrhosis / Q000503:physiopathology / Q000601:surgery*; D016031:Liver Transplantation / Q000502:physiology*; D008297:Male; D008661:Metabolism, Inborn Errors / Q000503:physiopathology / Q000601:surgery*; D016853:Muromonab-CD3 / Q000008:administration & dosage / Q000009:adverse effects; D009460:Neurologic Examination; D011183:Postoperative Complications / Q000175:diagnosis* / Q000503:physiopathology; D012307:Risk Factors; D013226:Status Epilepticus / Q000175:diagnosis / Q000503:physiopathology
chemical_list: D016853:Muromonab-CD3