title: The effects of inbreeding on DNA profile frequency estimates using PCR-based loci.
abstract: Estimates of inbreeding were determined using Wright's FST for loci used for PCR-based forensic analyses. The populations analyzed were African Americans, Caucasians, Hispanics, and Orientals. In most cases the FST values at each locus were less than 0.01. The FST values over all loci for African Americans, Caucasians, and Orientals ranged from 0.0015 to 0.0048. No substantial differences were observed for DNA profile frequency estimates when calculated under the assumption of independence or with the incorporation of FST.
authors.affiliation: Forensic Science Research and Training Center, FBI Academy, Quantico, VA 22135, USA.
authors.forename: B
authors.initials: B
authors.lastname: Budowle
mesh_terms: D003241:Consanguinity; D016172:DNA Fingerprinting; D005006:Ethnicity / Q000235:genetics; D005260:Female; D005819:Genetic Markers; D005828:Genetics, Population; D006021:Glycophorins / Q000235:genetics; D006683:HLA-DQ Antigens / Q000235:genetics; D059848:HLA-DQ alpha-Chains; D006454:Hemoglobins / Q000235:genetics; D006801:Humans; D008297:Male; D016133:Polymerase Chain Reaction; D011973:Receptors, LDL; D014809:Vitamin D-Binding Protein / Q000235:genetics
chemical_list: D005819:Genetic Markers; D006021:Glycophorins; D006683:HLA-DQ Antigens; D059848:HLA-DQ alpha-Chains; C069050:HLA-DQA1 antigen; D006454:Hemoglobins; D011973:Receptors, LDL; D014809:Vitamin D-Binding Protein