Immunohistochemical alterations in neuropeptide Y-positive nerve elements in rat cerebral cortex following acute phencyclidine treatment.
Phencyclidine (PCP) is a dissociative drug and has been known to be an antagonist of N-methyl-D-aspartate (NMDA) receptor. We examined possible effects of acute treatment with PCP on neuropeptide Y (NPY) immunoreactive nerve fibres and cell bodies in rat forebrain by immunocytochemistry combined with morphometric analysis. Following the treatment, significant alterations were observed throughout the cerebral cortex, compared with controls. NPY-positive perikarya were increased in number (178%) whereas NPY-positive fibres and terminals were decreased in area (38%). The result suggests that the cortical NPY neuronal system is controlled, at least partly, by glutamatergic inputs via NMDA receptor-mediated mechanisms.
Fukui
K
K
Department of Psychiatry, Kyoto Prefectural University of Medicine, Japan.
Kawashima
Y
Y
Iizumi
H
H
Utsumi
H
H
Nakajima
T
T
D000818:Animals; D002540:Cerebral Cortex / Q000737:chemistry* / Q000473:pathology; D005069:Evaluation Studies as Topic; D007150:Immunohistochemistry; D008297:Male; D009412:Nerve Fibers / Q000737:chemistry* / Q000473:pathology; D009478:Neuropeptide Y / Q000032:analysis*; D010622:Phencyclidine / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000032:analysis; D013997:Time Factors; D014660:Vasoactive Intestinal Peptide / Q000032:analysis
D009478:Neuropeptide Y; D014660:Vasoactive Intestinal Peptide; D013004:Somatostatin; D010622:Phencyclidine