title: Radiation-induced carcinoma of the penis.
abstract: Five patients with a second penile cancer following irradiation of a primary squamous cell carcinoma of the penis were treated at our cancer. The first cancers had completely regressed within 4 months of irradiation. The second cancers developed in the radiation field at a mean latent period of 158 months (range 124-242). Further, all patients had experienced early radiation reaction and showed late radiation stigmata, pointing to the possible radiation-induced nature of the second cancer. Although all cancers were squamous cell carcinomas, the second cancers were uniformly invasive and of a higher grade than the first. Radiation-induced second cancers, although rare, should be considered a late complication of primary irradiation of squamous cell carcinoma of the penis.
authors.affiliation: Department of Genitourinary Surgery, Cancer Institute (WIA), Adyar, Madras, India.
authors.forename: R
authors.initials: R
authors.lastname: Ravi
mesh_terms: D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000473:pathology / Q000532:radiotherapy*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009381:Neoplasms, Radiation-Induced / Q000209:etiology* / Q000473:pathology; D016609:Neoplasms, Second Primary / Q000209:etiology* / Q000473:pathology; D010412:Penile Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects; D012189:Retrospective Studies