Chemical and pharmacological characterization of Erythrophleum lasianthum alkaloids.
Two alkaloids 1 and 2 were isolated from the seeds of Erythrophleum lasianthum. Their structures were assigned by spectroscopic and chemical means as 3 beta-hydroxynorerythrosuamine (1) and its 3-O-beta-D-glucopyranoside (2). In spontaneously beating atria, both compounds 1 and 2 showed a marked and concentration-dependent positive inotropic activity and a weak negative chronotropic activity. The positive inotropic effect induced by 1 and 2 was not modified by propranolol, prazosin, carbachol, and ranitidine plus pyrilamine. Both 1 and 2 were very active in inhibiting the Na+/K(+)-ATPase isolated from bovine cardiac sarcolemmal vesicles.
Verotta
L
L
Aburjai
T
T
Rogers
C B
CB
Dorigo
P
P
Maragno
I
I
Fraccarollo
D
D
Santostasi
G
G
Gaion
R M
RM
Floreani
M
M
Carpenedo
F
F
D000470:Alkaloids / Q000737:chemistry* / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D007887:Fabaceae / Q000737:chemistry*; D006168:Guinea Pigs; D006325:Heart Atria; D066298:In Vitro Techniques; D008519:Medicine, Traditional; D009200:Myocardial Contraction / Q000187:drug effects*; D009206:Myocardium / Q000201:enzymology; D010042:Ouabain / Q000494:pharmacology; D008517:Phytotherapy; D010946:Plants, Medicinal; D012110:Reserpine / Q000494:pharmacology; D012508:Sarcolemma / Q000201:enzymology; D012639:Seeds / Q000737:chemistry*; D000254:Sodium-Potassium-Exchanging ATPase / Q000378:metabolism*; D013019:South Africa
D000470:Alkaloids; D010042:Ouabain; D012110:Reserpine; D000254:Sodium-Potassium-Exchanging ATPase