Awakening properties of modafinil without paradoxical sleep rebound: comparative study with amphetamine in the rat.
We have studied the effect of modafinil and amphetamine, two waking drugs, on the sleep-wake cycle of Sprague-Dawley rat. Both modafinil (64 or 128 mg/kg) and amphetamine (2.5 or 5 mg/kg) cause a dose dependent increase in wakefulness. However, amphetamine wakefulness is followed by a paradoxical sleep rebound on the injection day, whereas modafinil does not produce this effect. In modafinil-treated rats, the sleep pattern on the post-injection day is similar to that of controls, while that of amphetamine-treated rats is modified.
Touret
M
M
Department of Experimental Medicine, Claude Bernard University, Lyon, France.
Sallanon-Moulin
M
M
Jouvet
M
M
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D001143:Arousal; D001559:Benzhydryl Compounds / Q000494:pharmacology*; D000697:Central Nervous System Stimulants / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D008297:Male; D000077408:Modafinil; D051381:Rats; D017207:Rats, Sprague-Dawley; D012894:Sleep Stages / Q000187:drug effects; D012895:Sleep, REM / Q000187:drug effects*
D001559:Benzhydryl Compounds; D000697:Central Nervous System Stimulants; D000661:Amphetamine; D000077408:Modafinil