title: [Distal renal tubular acidosis presenting with rhabdomyolysis].
abstract: Severe hypokalemia is an uncommon cause of rhabdomyolysis. We describe a patient, 28-year-old woman, with distal renal tubular acidosis (DRTA) who developed severe hypokalemia and rhabdomyolysis. Muscle biopsy shows focal muscular necrosis mainly in type II muscle fibers and mild macrophagic reaction. After correcting the acidosis with oral administration of alkalinizing salts, clinical and laboratory improvement was seen. This clearly establish a causal relationship between the positive acid balance, hypokalemia and the muscular manifestation in DRTA.
authors.affiliation: Departamento de Neurologia, Neurocirurgia e Neurologia Experimental, Escola Paulista de Medicina EPM, São Paulo, Brasil.
authors.forename: E
authors.initials: E
authors.lastname: Zanoteli
authors.forename: A S
authors.initials: AS
authors.lastname: De Oliveira
authors.forename: C H
authors.initials: CH
authors.lastname: Tengan
authors.forename: M P
authors.initials: MP
authors.lastname: Morita
authors.forename: B
authors.initials: B
authors.lastname: Schmidt
authors.forename: A A
authors.initials: AA
authors.lastname: Gabbai
mesh_terms: D000141:Acidosis, Renal Tubular / Q000150:complications* / Q000188:drug therapy / Q000473:pathology; D000328:Adult; D003937:Diagnosis, Differential; D005260:Female; D006801:Humans; D007008:Hypokalemia / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D011189:Potassium Chloride / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology; D017693:Sodium Bicarbonate / Q000627:therapeutic use
chemical_list: D011189:Potassium Chloride; D017693:Sodium Bicarbonate