title: Lipid profiles of cerebral gray matter and livers of macaque monkeys Macaca fascicularis and Macaca fuscata fuscata: a comparative study during development.
abstract: The lipid and fatty acid profiles in cerebral gray matter and livers were studied in macaque monkeys (Macaca fascicularis and M. fuscata fuscata) of different ages. In cerebral gray matter, the phosphatidylcholine/phosphatidylethanolamine (PC/PE) ratio decreased in animals more than 3 years old, while the cholesterol/lipid-phosphorus ratios and the unsaturation indices increased, as compared with those in fetuses and newborns. The level of 22:6n-3 in PE of cerebral gray matter increased up to 3 years old, mainly by replacing 20:4n-6, whereas the level in phosphatidylserine did not change significantly with age. The hepatic lipid-phosphorus levels and PC/PE ratios were lower in newborns than in animals more than 3 years old. The level of 22:6n-3 in liver phospholipid did not change, while that of 20:4n-6 was lower in animals more than 3 years old than in newborns.
authors.affiliation: Department of Applied Biological Chemistry, Faculty of Agriculture, Tohoku University, Sendai, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Kanazawa
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Fujimoto
mesh_terms: D000375:Aging / Q000378:metabolism*; D000818:Animals; D000831:Animals, Newborn; D002540:Cerebral Cortex / Q000196:embryology / Q000378:metabolism*; D002784:Cholesterol / Q000737:chemistry / Q000378:metabolism; D002855:Chromatography, Thin Layer; D005227:Fatty Acids / Q000032:analysis / Q000378:metabolism*; D050356:Lipid Metabolism; D008055:Lipids / Q000737:chemistry; D008099:Liver / Q000196:embryology / Q000378:metabolism*; D008251:Macaca; D008252:Macaca fascicularis; D010713:Phosphatidylcholines / Q000737:chemistry / Q000378:metabolism; D010714:Phosphatidylethanolamines / Q000737:chemistry / Q000378:metabolism; D010718:Phosphatidylserines / Q000737:chemistry / Q000378:metabolism; D010743:Phospholipids / Q000737:chemistry / Q000378:metabolism; D010758:Phosphorus / Q000737:chemistry / Q000378:metabolism
chemical_list: D005227:Fatty Acids; D008055:Lipids; D010713:Phosphatidylcholines; D010714:Phosphatidylethanolamines; D010718:Phosphatidylserines; D010743:Phospholipids; D010758:Phosphorus; D002784:Cholesterol