[Increase of kidney enzymes in urine after administration of contrast media: comparison of the nephrotoxicity of ionic and nonionic substances].
In a double blind clinical study, 50 patients with healthy kidneys were tested for the discharge of renal marker proteins before and after receiving a high or low osmoloar contrast medium (Meglium-Ioglicinat, Imeprol) using i.v. urography. The renal excretion of the tubular indicator enzymes alanine aminopeptidase, beta-Glutamyltranspeptidase and alkaline phosphatase increased in all patients after administration of the contrast media. The enzymuria was significantly lower with the non-ionic contrast medium with the ionic one, thus demonstrating that the non-ionic contrast medium has a lower nephrotoxic potential than the conventional ionic contrast medium. Three independent investigators evaluated the radiograms with regard to the contrast quality using prearranged criteria in a 5 point system. The diversity of the evaluations clearly favoured the non-ionic contrast medium.
Tschakert
H
H
Klinik für Radiologische Diagnostik und Nuklearmedizin des Knappschaftskrankenhauses Bardenberg, Akademisches Lehrkrankenhaus der RWTH Aachen.
Matern-Pinzek
R
R
Schaffeldt
J
J
D000368:Aged; D000469:Alkaline Phosphatase / Q000652:urine*; D018826:CD13 Antigens / Q000652:urine; D003287:Contrast Media / Q000633:toxicity*; D004311:Double-Blind Method; D006801:Humans; D007479:Iopamidol / Q000031:analogs & derivatives* / Q000633:toxicity; D007483:Iothalamic Acid / Q000031:analogs & derivatives* / Q000633:toxicity; D007668:Kidney / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications / Q000000981:diagnostic imaging; D011468:Prostatectomy; D014567:Urography; D005723:gamma-Glutamyltransferase / Q000652:urine*
D003287:Contrast Media; D007483:Iothalamic Acid; C057937:iomeprol; C016525:ioglicic acid; D005723:gamma-Glutamyltransferase; D000469:Alkaline Phosphatase; D018826:CD13 Antigens; D007479:Iopamidol