title: Fluoride retention of incipient enamel lesions after treatment with a calcium fluoride varnish in vivo.
abstract: The aim was to determine the fluoride retention in plaque-covered and clean incipient enamel lesions after topical application of a CaF2/NaF varnish (Bifluorid 12). In 50 specimens of bovine enamel an incipient lesion was produced with acidic hydroxyethylcellulose (pH 4.8; 72 h). 40 specimens were fluoride varnished; the 10 remaining specimens were used for measuring baseline fluoride content. Each six of the fluoridated specimens were recessed in the buccal aspects of an intraoral appliance worn for 5 days. During the experimental period one side of the appliance was kept clean, and plaque growth was allowed on the other. KOH-soluble and structurally bound fluoride were determined immediately, 1 day, 3 days and 5 days after fluoridation, and compared with the baseline fluoride content of the enamel. Immediately after fluoridation, a considerable amount of KOH-soluble fluoride was bound, but after 5 days 80% had been lost. Simultaneously a significant increase of non-KOH-soluble or structurally bound fluoride was detected in both plaque-covered and clean enamel. It is evident that this CaF2/NaF varnish deposits more KOH-soluble fluoride on the surface of demineralized enamel than other varnishes, but after 5 days fluoride retention is similar to that from other varnishes.
authors.affiliation: Department of Operative Dentistry, University Clinic of Dentistry, Freiburg, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Attin
authors.forename: O
authors.initials: O
authors.lastname: Hartmann
authors.forename: R D
authors.initials: RD
authors.lastname: Hilgers
authors.forename: E
authors.initials: E
authors.lastname: Hellwig
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D002124:Calcium Fluoride / Q000737:chemistry / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002417:Cattle; D003731:Dental Caries / Q000378:metabolism* / Q000517:prevention & control; D003743:Dental Enamel / Q000378:metabolism*; D003773:Dental Plaque / Q000188:drug therapy; D005460:Fluorides, Topical / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006801:Humans; D006878:Hydroxides; D017680:Potassium Compounds; D012969:Sodium Fluoride / Q000493:pharmacokinetics / Q000627:therapeutic use; D012995:Solubility; D014089:Tooth Remineralization / Q000379:methods*
chemical_list: C094502:Bifluorid 12; D005460:Fluorides, Topical; D006878:Hydroxides; D017680:Potassium Compounds; D012969:Sodium Fluoride; D002124:Calcium Fluoride; C029943:potassium hydroxide