Repeated diazepam administration influences 5-HT1A receptor binding in the rat brain.
Repeated administration of diazepam for 14 days (5 mg/kg daily) resulted in a significant increase of 5-HT1A receptor density in the midbrain of the rat. Bmax values were increased from 239.6 to 684.9 fmol/mg. The affinity constants (KD) were also increased, from 0.97 to 3.01 nM/l.
Rump
S
S
Department of Pharmacology and Toxicology, Military Institute of Hygiene and Epidemiology, Warsaw, Poland.
Jakowicz
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I
D000818:Animals; D001665:Binding Sites; D001921:Brain; D003975:Diazepam / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects*; D013997:Time Factors
D011985:Receptors, Serotonin; D003975:Diazepam