[Function of cytokines in cartilage degradation].
Growth-hormones like Insulin-Like-Growth-Hormone-1 (IGF-1) and Tissue-Growth-Factor-beta (TGF-beta) and Cytokines IL-1, IL-6 and TGF-alpha play an important part in the homeostasis and also degradation of the articular cartilage. IL-1 stimulates the production of proteolytic enzymes and inhibits the synthesis of aggrecan and leads therefore to a degradation of the cartilage. TNF-alpha acts in a similar way, whereas the significance of IL-6 for chondrocytes is not yet fully understood. TGF-beta and IGF-1 in contrast have a positive influence on cartilage metabolism, f. ex. TGF-beta stimulates the synthesis of the natural occurring metalloproteinase-inhibitor (TIMP).
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Institut für Rheumatologie, Medizinischen Institutszentrums der Kurstadt Baden.
D002358:Cartilage, Articular / Q000503:physiopathology*; D016207:Cytokines / Q000502:physiology*; D006023:Glycoproteins / Q000096:biosynthesis; D006706:Homeostasis / Q000502:physiology; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000502:physiology; D007375:Interleukin-1 / Q000502:physiology; D015850:Interleukin-6 / Q000502:physiology; D010003:Osteoarthritis / Q000503:physiopathology*; D019714:Tissue Inhibitor of Metalloproteinases; D016211:Transforming Growth Factor alpha / Q000502:physiology; D016212:Transforming Growth Factor beta / Q000502:physiology
D016207:Cytokines; D006023:Glycoproteins; D007375:Interleukin-1; D015850:Interleukin-6; D019714:Tissue Inhibitor of Metalloproteinases; D016211:Transforming Growth Factor alpha; D016212:Transforming Growth Factor beta; D007334:Insulin-Like Growth Factor I