title: First observation of microadenomas in the ileal mucosa of patients with familial adenomatous polyposis and colectomies.
abstract: OBJECTIVE
  Little data are available on the type and prevalence of mucosal changes involved in the development of ileal adenomas in patients with familial adenomatous polyposis who have undergone colectomy. However, colonic metaplasia of the ileal epithelium is thought to be an important step in the development of such adenomas.
  
  
  METHODS
  Retrograde endoscopy and biopsy of the distal ileum were performed in 17 affected patients who underwent total colectomy or proctocolectomy 3-184.1 months (mean, 80.3 +/- 13.9 months) before the study.
  
  
  RESULTS
  Macroscopic ileal polyps were identified in 14 (82.4%) patients. All polyps were sessile and 1-5 mm in size. Histological analysis showed adenomas in 9 (52.9%) patients and lymphoid hyperplasia or inflammation in the others. In 1 patient, an area of colonic-type metaplasia of the ileal mucosa was found close to an adenoma. However, in 5 (29.4%) patients, random biopsy specimens of the normal-appearing mucosa showed foci of abnormal crypts in the absence of metaplasia, with histological appearance similar to the findings described in dysplastic aberrant crypt foci of the colon. Such lesions, previously observed only in colorectal mucosa and referred to as microadenomas or oligocryptal adenomas, are considered putative preneoplastic abnormalities.
  
  
  CONCLUSIONS
  Although the hypothesized sequence normal ileal mucosa leading to colonic-type metaplasia leading to adenoma cannot be excluded, our findings support the sequence normal ileal mucosa leading to microadenoma leading to gross adenoma and possibly cancer as the main histogenetic pathway, as already suggested for the large bowel.
authors.affiliation: Department of Digestive Endoscopy, Ospedale S. Maria Nuova, Reggio Emilia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Bertoni
authors.forename: R
authors.initials: R
authors.lastname: Sassatelli
authors.forename: E
authors.initials: E
authors.lastname: Nigrisoli
authors.forename: P
authors.initials: P
authors.lastname: Tansini
authors.forename: L
authors.initials: L
authors.lastname: Roncucci
authors.forename: M
authors.initials: M
authors.lastname: Ponz de Leon
authors.forename: G
authors.initials: G
authors.lastname: Bedogni
mesh_terms: D000236:Adenoma / Q000473:pathology*; D011125:Adenomatous Polyposis Coli / Q000473:pathology* / Q000601:surgery; D000293:Adolescent; D000328:Adult; D001706:Biopsy; D003082:Colectomy; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007078:Ileal Neoplasms / Q000473:pathology*; D007413:Intestinal Mucosa / Q000473:pathology*; D007417:Intestinal Polyps / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies