[New in vitro test systems].
Experimental in vitro systems are discussed with reference to their use as models für the analysis of basal tumor-host interactions. Multiple functions of macrophages are treated and there is also a special focus on the differentiation of macrophages in vitro and the influence of cocultures with the influence of cocultures with tumour cells (monolayer, spheroids). These experiments have shown that differentiation can be suppressed by tumour cells with three-dimensional growth. These findings are of interest for (a) adoptive immunotherapy and (b) the interpretation of tumour-infiltrating macrophages. These tests are not suitable for in vitro monitoring of clinical immunotherapy.
Hofstädter
F
F
Institut für Pathologie, Universität Regensburg.
Konur
A
A
Andreesen
R
R
Knüchel
R
R
D002295:Carcinoma, Transitional Cell; D002460:Cell Line; D016207:Cytokines / Q000502:physiology; D006801:Humans; D016130:Immunophenotyping; D016219:Immunotherapy, Adoptive; D008262:Macrophage Activation / Q000276:immunology; D016173:Macrophage Colony-Stimulating Factor / Q000502:physiology; D008264:Macrophages / Q000276:immunology*; D014407:Tumor Cells, Cultured / Q000276:immunology*; D014410:Tumor Stem Cell Assay / Q000379:methods*; D001749:Urinary Bladder Neoplasms
D016207:Cytokines; D016173:Macrophage Colony-Stimulating Factor