GERI-BP001 compounds, new inhibitors of acyl-CoA: cholesterol acyltransferase from Aspergillus fumigatus F37. I. Production, isolation, and physico-chemical and biological properties.
GERI-BP001 compounds, new inhibitors of acyl-CoA:cholesterol acyltransferase (ACAT), were isolated from a culture broth of Aspergillus fumigatus F37 by acetone extraction, EtOAc extraction, SiO2 column chromatography, and reverse phase HPLC. GERI-BP001 M, A, and B inhibit ACAT activity in an enzyme assay system using rat liver microsomes by 50% at concentrations of 42, 94, and 40 microM, respectively.
Jeong
T S
TS
Bioproducts Research Group, Korea Research Institute of Bioscience & Biotechnology, KIST, Taejon.
Kim
S U
SU
Son
K H
KH
Kwon
B M
BM
Kim
Y K
YK
Choi
M U
MU
Bok
S H
SH
D000818:Animals; D001232:Aspergillus fumigatus; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D008862:Microsomes, Liver / Q000187:drug effects; D011725:Pyridines / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D051381:Rats; D012717:Sesquiterpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*
D004791:Enzyme Inhibitors; C096593:GERI-BP001 A; C096594:GERI-BP001 B; C096592:GERI-BP001 M; D011725:Pyridines; D012717:Sesquiterpenes; D002785:Sterol O-Acyltransferase