[Mechanisms of systemic labilization of cellular membranes during long-term deprivation of paradoxical sleep].
Four-day deprivation of paradoxal sleep was found to be followed by deep destructive changes in mitochondrial membranes of the brain and erythrocytes. At the same time the activity of the anti-radical defense system was suppressed and lipid peroxidation products accumulated, causing abnormal changes in the ratio of particular lipid components and impairing the functional activity of biological membranes. It is suggested that the lesion might be systemic and the targeted use of membrane protective agents should be to correct morphofunctional disorders in this abnormality.
Kresiun
V I
VI
Rozhskovskiĭ
Ia V
IaV
D000818:Animals; D002462:Cell Membrane / Q000502:physiology; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D012892:Sleep Deprivation / Q000502:physiology*; D012895:Sleep, REM / Q000502:physiology*; D013997:Time Factors