title: [Cerebral abscess. Clinical review of 26 cases].
abstract: BACKGROUND
  The introduction of new diagnostic and therapeutic techniques has changed the clinical attitude and consequences of brain abscesses (BA).
  
  
  OBJECTIVE
  To analyse clinical-radiological features, therapy, prognostic factors and evolution of BA in our institution.
  
  
  METHODS
  Retrospective study of all clinical records of patients diagnosed with BA from 1982 to 1992.
  
  
  RESULTS
  Twenty-six patients with a mean age of 46.2 years were selected. The incidence was 2.6 patients/10,000 admission/year. Among 17 patients (65%) some extraprenchymatous infectious focus was found, which was located at the otorhynolaryngeal area in twelve patients. Mean duration of symptoms was 12.9 days, headache being the most common of them (69%). With CT 18 patients had a single mass, eight patients multiple masses, and 21 patients a ring enhancement when the contrast material was introduced. The causative organism was recovered from 15 patients. The organism recovered more frequently were Streptococcus spp, Enterobacteriaceae and Staphylococcus aureus. Twenty patients (77%) underwent surgical therapy, which consisted in ablation (12) or drainage (8). All patients received antibiotics for a mean of 37 days: the most frequent antibiotic combination used was penicillin+chloramphenicol. Six patients died (23%) and 7 remained with sequelae. Although statistically non-significant, the acute presentation was associated with a higher mortality rate, and the use of dexamethasone was associated with a lower mortality rate (p = 0.053 and 0.062, respectively).
  
  
  CONCLUSIONS
  BA is associated with a high mortality rate and a high sequelae rate despite appropriate diagnostic and therapeutic measures. ORL infection is the most frequent predisposing factor. The use of dexamethasone is not associated with a higher mortality rate.
authors.affiliation: Servicio de Medicina Interna II, Clínica Puerta de Hierro, Universidad Autónoma de Madrid.
authors.forename: E
authors.initials: E
authors.lastname: Estirado de Cabo
authors.forename: J A
authors.initials: JA
authors.lastname: Arzuaga Torre
authors.forename: F
authors.initials: F
authors.lastname: Román García
authors.forename: J M
authors.initials: JM
authors.lastname: del Pozo García
authors.forename: R
authors.initials: R
authors.lastname: Pérez Maestu
authors.forename: J
authors.initials: J
authors.lastname: Martínez López de Letona
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001922:Brain Abscess / Q000453:epidemiology / Q000382:microbiology / Q000628:therapy; D002648:Child; D005260:Female; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D011379:Prognosis; D012189:Retrospective Studies