[The reinfusion of blood and the administration of dalargin in experimental hemorrhagic shock].
In acute experiment on 95 adult rabbits it was determined that during the subdivided blood exfusion from femoral artery in the volume of (16 + 1) ml/kg the reversible hemorrhagic shock occurs and the animals survive without the hemorrhage compensation. The increase of hemorrhage volume up to (23 + 3) ml/kg leads to lethal hemorrhagic shock. The heparinized blood reinfusion in the early period promotes the survival of the whole of animals, in the late period it promotes trustworthy their life span increase. Under the influence of dalargin intravenous infusion in the dose of 0.1 mg/kg after the blood reinfusion in the late period of shock all the animals survived. Intravenous infusion of dalargin is expedient for the increase of the transfusion therapy effectiveness in the late period of hemorrhagic shock.
Sherman
D M
DM
Trach
V M
VM
D000818:Animals; D001804:Blood Transfusion, Autologous; D003131:Combined Modality Therapy; D016308:Enkephalin, Leucine-2-Alanine / Q000008:administration & dosage / Q000031:analogs & derivatives*; D005069:Evaluation Studies as Topic; D006439:Hemodynamics; D011817:Rabbits; D012771:Shock, Hemorrhagic / Q000401:mortality / Q000503:physiopathology / Q000628:therapy*; D013997:Time Factors
D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-