title: Down's syndrome as a model for the decisive role of maternal lineage in human evolution.
abstract: The study of human evolution and the mechanism of this process can be approached from physical anthropology, which examines phenotypic expression and molecular evolution, which investigates genotypic change. Alternatively, we suggest that human evolutional process can also be explained using present day examples of abberations in evolution. Thus, from both genotypic and phenotypic perspectives, we address the question of whether Down's syndrome is an instructive example to look into the decisive role of maternal lineage in human evolution.
authors.affiliation: Department of Biological Chemistry, Hebrew University, Jerusalem, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Goshen
authors.forename: B
authors.initials: B
authors.lastname: Gonik
authors.forename: N
authors.initials: N
authors.lastname: DeGroot
authors.forename: A
authors.initials: A
authors.lastname: Hochberg
mesh_terms: D000818:Animals; D002891:Chromosomes, Human, Pair 21; D004314:Down Syndrome / Q000235:genetics*; D005260:Female; D018507:Gene Expression Regulation, Developmental; D015186:Hominidae / Q000235:genetics; D006801:Humans; D007231:Infant, Newborn; D009630:Nondisjunction, Genetic; D010802:Phylogeny; D011247:Pregnancy; D011323:Primates / Q000235:genetics; D044469:Racial Groups / Q000235:genetics