title: Results of a multicenter trial using the BTA test to monitor for and diagnose recurrent bladder cancer.
abstract: OBJECTIVE
  We compare the Bard BTA (bladder tumor antigen) test to voided cytology studies in patients undergoing surveillance cystoscopy for recurrent bladder cancer.
  
  
  METHODS
  A prospective, blinded, multicenter trial was performed.
  
  
  RESULTS
  A total of 499 patients underwent 1,014 cystoscopic examinations and tumor was identified in 151. The bladder tumor antigen test was more sensitive than cytology studies in detecting recurrent cancer (p < 0.001), being positive in 61 cases versus 25 for cytology. The trial in healthy volunteers and nonurological patients estimates bladder tumor antigen test specificity to be 95.9%.
  
  
  CONCLUSIONS
  The bladder tumor antigen test is a simple, rapid and inexpensive adjunct to cystoscopy, and the results are equivalent or superior to those of voided cytology as performed in this trial.
authors.affiliation: Department of Urology, University of Texas Health Science Center, San Antonio, USA.
authors.forename: M F
authors.initials: MF
authors.lastname: Sarosdy
authors.forename: R W
authors.initials: RW
authors.lastname: deVere White
authors.forename: M S
authors.initials: MS
authors.lastname: Soloway
authors.forename: J
authors.initials: J
authors.lastname: Sheinfeld
authors.forename: M A
authors.initials: MA
authors.lastname: Hudson
authors.forename: P F
authors.initials: PF
authors.lastname: Schellhammer
authors.forename: M V
authors.initials: MV
authors.lastname: Jarowenko
authors.forename: G
authors.initials: G
authors.lastname: Adams
authors.forename: B A
authors.initials: BA
authors.lastname: Blumenstein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000951:Antigens, Neoplasm / Q000097:blood*; D003558:Cystoscopy; D005260:Female; D006801:Humans; D008297:Male; D008991:Monitoring, Physiologic; D009367:Neoplasm Staging; D011237:Predictive Value of Tests; D011446:Prospective Studies; D012680:Sensitivity and Specificity; D016037:Single-Blind Method; D001749:Urinary Bladder Neoplasms / Q000097:blood / Q000175:diagnosis* / Q000276:immunology / Q000652:urine; D014556:Urine / Q000166:cytology*
chemical_list: D000951:Antigens, Neoplasm