title: Further evidence supporting the importance of and the restrictions on a carbon-centered radical for high antimalarial activity of 1,2,4-trioxanes like artemisinin.
authors.affiliation: Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, USA.
authors.forename: G H
authors.initials: GH
authors.lastname: Posner
authors.forename: D
authors.initials: D
authors.lastname: Wang
authors.forename: J N
authors.initials: JN
authors.lastname: Cumming
authors.forename: C H
authors.initials: CH
authors.lastname: Oh
authors.forename: A N
authors.initials: AN
authors.lastname: French
authors.forename: A L
authors.initials: AL
authors.lastname: Bodley
authors.forename: T A
authors.initials: TA
authors.lastname: Shapiro
mesh_terms: D000962:Antimalarials / Q000737:chemistry* / Q000494:pharmacology; D037621:Artemisinins; D002244:Carbon / Q000737:chemistry; D006571:Heterocyclic Compounds / Q000737:chemistry* / Q000494:pharmacology; D012717:Sesquiterpenes / Q000737:chemistry / Q000494:pharmacology; D013329:Structure-Activity Relationship
chemical_list: D000962:Antimalarials; D037621:Artemisinins; D006571:Heterocyclic Compounds; D012717:Sesquiterpenes; D002244:Carbon; C031327:artemisinin