title: Granulomatous interstitial nephritis associated with hydrochlorothiazide/amiloride.
abstract: A 74-year-old woman developed acute renal failure and granulomatous interstitial nephritis associated with hydrochlorothiazide/amiloride. On stopping the drug the renal function improved, but not significantly. Around 20 months after prednisone administration, the renal function had stabilized, with a moderate degree of renal insufficiency. The case is discussed, and some aspects of acute interstitial nephritis induced by diuretics are briefly reviewed.
authors.affiliation: Section of Nephrology, General Hospital of Elche, Spain.
authors.forename: R
authors.initials: R
authors.lastname: Enríquez
authors.forename: J B
authors.initials: JB
authors.lastname: Cabezuelo
authors.forename: C
authors.initials: C
authors.lastname: González
authors.forename: J
authors.initials: J
authors.lastname: Lacueva
authors.forename: A
authors.initials: A
authors.lastname: Teruel
authors.forename: J
authors.initials: J
authors.lastname: Fernández
authors.forename: M D
authors.initials: MD
authors.lastname: Arenas
mesh_terms: D058186:Acute Kidney Injury / Q000139:chemically induced* / Q000628:therapy; D000368:Aged; D000584:Amiloride / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D006099:Granuloma / Q000139:chemically induced* / Q000188:drug therapy; D006801:Humans; D006852:Hydrochlorothiazide / Q000009:adverse effects* / Q000627:therapeutic use; D006973:Hypertension / Q000188:drug therapy; D009395:Nephritis, Interstitial / Q000139:chemically induced* / Q000188:drug therapy; D011241:Prednisone / Q000627:therapeutic use
chemical_list: D006852:Hydrochlorothiazide; D000584:Amiloride; D011241:Prednisone