title: Ductal carcinoma in situ: MR imaging-histopathologic correlation.
abstract: OBJECTIVE
  To correlate histopathologic and magnetic resonance (MR) imaging findings of ductal carcinoma in situ (DCIS).
  
  
  METHODS
  Thirty-six women with DCIS underwent preoperative contrast material-enhanced subtraction dynamic MR imaging. Concomitant early contrast enhancement in the breast parenchyma with normal vessels was considered a positive finding. The size and shape of early enhancement were correlated with the size and density packing of ducts involved by DCIS. Tumor angiogenesis in the stroma that surrounded the ducts was evaluated with immunoperoxidase staining.
  
  
  RESULTS
  Early contrast enhancement was demonstrated in 34 patients with DCIS but not in two patients with comedo-type DCIS. Tumor angiogenesis was demonstrated in the stroma. The size and morphology of contrast-enhanced lesions significantly correlated with the size (P = .0085) and density packing of ducts involved by DCIS (P = .012).
  
  
  CONCLUSIONS
  Contrast enhancement on dynamic MR images of DCIS may be due to the presence of tumor angiogenesis in the stroma.
authors.affiliation: Department of Radiology, Institut Gustave Roussy, Villejuif, France.
authors.forename: R
authors.initials: R
authors.lastname: Gilles
authors.forename: B
authors.initials: B
authors.lastname: Zafrani
authors.forename: J M
authors.initials: JM
authors.lastname: Guinebretière
authors.forename: M
authors.initials: M
authors.lastname: Meunier
authors.forename: O
authors.initials: O
authors.lastname: Lucidarme
authors.forename: A A
authors.initials: AA
authors.lastname: Tardivon
authors.forename: F
authors.initials: F
authors.lastname: Rochard
authors.forename: D
authors.initials: D
authors.lastname: Vanel
authors.forename: S
authors.initials: S
authors.lastname: Neuenschwander
authors.forename: R
authors.initials: R
authors.lastname: Arriagada
mesh_terms: D001940:Breast / Q000473:pathology*; D001943:Breast Neoplasms / Q000175:diagnosis*; D002278:Carcinoma in Situ / Q000175:diagnosis*; D018270:Carcinoma, Ductal, Breast / Q000175:diagnosis*; D003287:Contrast Media; D005260:Female; D006571:Heterocyclic Compounds; D006801:Humans; D008279:Magnetic Resonance Imaging; D008875:Middle Aged; D009942:Organometallic Compounds; D011446:Prospective Studies; D012680:Sensitivity and Specificity
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate