Plasmalogen oxidation in human serum lipoproteins.
The content of plasmalogens in lipoproteins--very low density lipoprotein (VLDL), low density lipoprotein (LDL) and high density lipoprotein (HDL)--in human serum was determined and compared with that after oxidation of the lipoproteins. Similarly, the content of alpha-hydroxyaldehydes produced from plasmalogens via their epoxids during lipidperoxidation (LPO) was studied. Incubation with Fe+ +/ascorbate results in a dramatic decrease in plasmalogens that correlates with an appropriate increase in alpha-hydroxyaldehydes. VLDL and LDL plasmalogens were oxidized to a greater extend (99% decrease) compared to HDL plasmalogens (35%). This finding is discussed with respect to atherogenesis and the recently postulated protective qualities of plasmalogens.
Felde
R
R
Institut für Organische Chemie I, Universität Bayreuth, Germany.
Spiteller
G
G
D000447:Aldehydes / Q000032:analysis / Q000737:chemistry; D001205:Ascorbic Acid / Q000737:chemistry / Q000494:pharmacology; D004852:Epoxy Compounds / Q000737:chemistry; D006801:Humans; D015227:Lipid Peroxidation; D008074:Lipoproteins / Q000097:blood* / Q000737:chemistry; D008075:Lipoproteins, HDL / Q000097:blood / Q000737:chemistry; D008077:Lipoproteins, LDL / Q000097:blood / Q000737:chemistry; D008079:Lipoproteins, VLDL / Q000097:blood / Q000737:chemistry; D013058:Mass Spectrometry; D010084:Oxidation-Reduction; D010545:Peroxides / Q000737:chemistry / Q000494:pharmacology; D010955:Plasmalogens / Q000097:blood / Q000737:chemistry*
D000447:Aldehydes; D004852:Epoxy Compounds; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D008077:Lipoproteins, LDL; D008079:Lipoproteins, VLDL; D010545:Peroxides; D010955:Plasmalogens; D001205:Ascorbic Acid