title: Protein-mediated protein maturation in eukaryotes.
abstract: Eukaryotic cells have developed particular strategies to support the critical steps in protein maturation that starts in the cytosol with the birth of a nascent polypeptide chain, and ends when the protein has reached the appropriate compartment and/or has attained its mature structure. Many of the cellular proteins that have evolved to promote maturation processes are constitutively expressed members of the highly conserved heat shock protein (hsp) family, also known as 'molecular chaperones'. Protein-mediated processes that occur in the cytosol are discussed.
authors.affiliation: Institut für Biochemie, Heidelberg, Germany.
authors.forename: I G
authors.initials: IG
authors.lastname: Haas
mesh_terms: D001692:Biological Transport; D002451:Cell Compartmentation; D003600:Cytosol / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism; D006360:Heat-Shock Proteins / Q000378:metabolism*; D017510:Protein Folding; D011499:Protein Processing, Post-Translational
chemical_list: D006360:Heat-Shock Proteins