Neonatal alloimmune thrombocytopenia involving HPA-5b (Br(a)): a rare Japanese case.
Neonatal alloimmune thrombocytopenia (NAIT) is caused by platelet antigen incompatibility between the mother and fetus. The frequency of NAIT varies among ethnic groups. In Caucasians, HPA-5b (Br(a)) is the antigen that is second most frequently implicated. In Japan, NAIT due to anti-HPA-5b antibody is quite rare. The present case is the second case of Br(a)-NAIT in Japanese and the first case serologically confirmed by monoclonal antibody-specific immobilization of platelet antigens.
Suda
H
H
Perinatal Medical Center, Morioka Red Cross Hospital, Japan.
Ohto
H
H
Tohyama
Y
Y
Morita
S
S
Ishijima
A
A
Ishikawa
K
K
Chida
S
S
Matsuda
I
I
D016824:Antigens, Human Platelet / Q000276:immunology*; D001327:Autoimmune Diseases / Q000151:congenital* / Q000276:immunology; D005260:Female; D006801:Humans; D007159:Immunologic Tests; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013921:Thrombocytopenia / Q000151:congenital* / Q000208:ethnology / Q000276:immunology*
C055973:5b alloantigen, human; D016824:Antigens, Human Platelet