title: Physiological relevance of T-tube model parameters with emphasis on arterial compliances.
abstract: The T-tube model of systemic arterial circulation was examined with respect to the physiological relevance of model parameters. root aortic pressure [Pao(t)] and flow [Qao(t)] and descending aortic flow [Qb(t)] were measured in anesthetized, open-chest dogs under control conditions, during inflation of a balloon positioned in the left external iliac artery (n = 5), and during infusion of vasoactive drugs nitroprusside (NTP, n = 4) and phenylephrine (PHL, n = 5). With Pao(t) as the input, the model accurately predicted both Qao(t) and Qb(t) under all conditions (r2 > 0.96). The balloon inflation data established the ability of the model to discriminate between proximal and distal arterial mechanical properties. Furthermore, proximal properties (i.e., tube characteristic impedances and transit times) were independent of distal properties such as terminal compliances and resistances (or equivalently, wave reflections). The effects of NTP and PHL were pharmacologically consistent and served to further validate this model. NTP primarily affected distal (load) properties, whereas PHL altered both load and tube parameters. Physiological interpretation of model parameters, particularly compliance, is also discussed. The ability of the model to correctly discriminate between proximal and distal arterial properties is relevant because these properties may affect cardiovascular function differently.
authors.affiliation: Department of Medicine, University of Chicago, Illinois 60637, USA.
authors.forename: S G
authors.initials: SG
authors.lastname: Shroff
authors.forename: D S
authors.initials: DS
authors.lastname: Berger
authors.forename: C
authors.initials: C
authors.lastname: Korcarz
authors.forename: R M
authors.initials: RM
authors.lastname: Lang
authors.forename: R H
authors.initials: RH
authors.lastname: Marcus
authors.forename: D E
authors.initials: DE
authors.lastname: Miller
mesh_terms: D000818:Animals; D001158:Arteries / Q000502:physiology*; D001696:Biomechanical Phenomena; D002404:Catheterization; D003187:Compliance; D004285:Dogs; D008955:Models, Cardiovascular; D014655:Vascular Resistance