title: Long-term sequelae of Palmar-Plantar erythrodysaesthesia syndrome secondary to 5-fluorouracil therapy.
abstract: Palmar-Plantar erythrodyasesthesia syndrome has been reported as a temporary complication of 5-fluorouracil therapy consisting of a debilitating erythema and tenderness of the skin of hands and feet. The syndrome has previously been observed to respond rapidly to either temporary cessation of chemotherapy or pyridoxine with little residual disability. We report a case which was characterized by persistent morbidity necessitating prolonged discontinuation of treatment.
authors.affiliation: Department of Surgical Oncology, Queen Elizabeth Military Hospital, Woolwich, London, UK.
authors.forename: G K
authors.initials: GK
authors.lastname: Banfield
authors.forename: I D
authors.initials: ID
authors.lastname: Crate
authors.forename: C L
authors.initials: CL
authors.lastname: Griffiths
mesh_terms: D004890:Erythema / Q000139:chemically induced*; D005472:Fluorouracil / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D008875:Middle Aged; D010292:Paresthesia / Q000139:chemically induced*
chemical_list: D005472:Fluorouracil