alpha-Lipoic acid as a biological antioxidant.
alpha-Lipoic acid, which plays an essential role in mitochondrial dehydrogenase reactions, has recently gained considerable attention as an antioxidant. Lipoate, or its reduced form, dihydrolipoate, reacts with reactive oxygen species such as superoxide radicals, hydroxyl radicals, hypochlorous acid, peroxyl radicals, and singlet oxygen. It also protects membranes by interacting with vitamin C and glutathione, which may in turn recycle vitamin E. In addition to its antioxidant activities, dihydrolipoate may exert prooxidant actions through reduction of iron. alpha-Lipoic acid administration has been shown to be beneficial in a number of oxidative stress models such as ischemia-reperfusion injury, diabetes (both alpha-lipoic acid and dihydrolipoic acid exhibit hydrophobic binding to proteins such as albumin, which can prevent glycation reactions), cataract formation, HIV activation, neurodegeneration, and radiation injury. Furthermore, lipoate can function as a redox regulator of proteins such as myoglobin, prolactin, thioredoxin and NF-kappa B transcription factor. We review the properties of lipoate in terms of (1) reactions with reactive oxygen species; (2) interactions with other antioxidants; (3) beneficial effects in oxidative stress models or clinical conditions.
Packer
L
L
Department of Molecular & Cell Biology, University of California, Berkeley 94720, USA.
Witt
E H
EH
Tritschler
H J
HJ
D000818:Animals; D000975:Antioxidants; D004194:Disease; D006801:Humans; D017665:Hydroxyl Radical; D015394:Molecular Structure; D017382:Reactive Oxygen Species; D008063:Thioctic Acid / Q000737:chemistry / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use
D000975:Antioxidants; D017382:Reactive Oxygen Species; D017665:Hydroxyl Radical; D008063:Thioctic Acid