Formulation of water disinfectant tablets for rural communities in Nigeria.
A water disinfectant tablet containing calcium hypochlorite as the main ingredient has been developed using a variety of excipients to improve the tablet characteristics. Avicel, polyvinylpyrrolidone, sodium hydrogen carbonate, calcium carbonate, sodium chloride and potassium chloride were used. Inclusion of polyvinylpyrrolidone together with calcium carbonate gave better tablet characteristics. Avicel though gave better tablet characteristics, promoted loss of chlorine from the tablets. Inclusion of inorganic salts were not satisfactory as they, enhanced atmospheric water absorption.
Sridhar
M K
MK
Department of Preventive and Social Medicine, College of Medicine, University of Ibadan, Nigeria.
Jaiyeoba
K T
KT
Ashefor
H O
HO
D017610:Calcium Compounds / Q000737:chemistry*; D002626:Chemistry, Pharmaceutical; D004353:Drug Evaluation, Preclinical; D004355:Drug Stability; D005079:Excipients; D006801:Humans; D009549:Nigeria; D012423:Rural Health; D013607:Tablets; D018508:Water Purification / Q000379:methods*
D017610:Calcium Compounds; D005079:Excipients; D013607:Tablets; C004488:calcium hypochlorite