[Research on rectal administration of bark of official Magnolia].
Fluorescence assay was applied to the determination of magnolol in rabbit blood, and the best way to administer the bark of official magnolia per rectal was established by orthogonal test. Then the two routes of administration were compared by AUC of magnolol and per rectal was found better than P.O. In addition, the modified isolated rectum-bag method was applied successfully to the research on rectal administration of bark of official magnolia.
Tan
Y
Y
Jiangxi Institute of Traditional Chinese Medicine, Nanchang.
Lu
W
W
Zhao
S
S
Hu
Y
Y
Ma
Z
Z
D000285:Administration, Rectal; D000818:Animals; D001682:Biological Availability; D001713:Biphenyl Compounds / Q000097:blood*; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000493:pharmacokinetics*; D005260:Female; D017705:Lignans; D008297:Male; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar; D013050:Spectrometry, Fluorescence
D001713:Biphenyl Compounds; D004365:Drugs, Chinese Herbal; D017705:Lignans; C005498:magnolol