Potential antitumor agent: steroidal bilactam ester of p-N, N-bis (2-chloroethyl) aminophenylacetic acid.
7 alpha-, 17 alpha-Diaza-7, 17-dioxo-B, D-dihomo-5-androsten 3 beta-p-N, N-bis (2- chloroethyl)aminophenylacetate, a modified steroidal alkylating agent, is active in the treatment of P388 and L1210 leukemias in vivo. The compound was also tested in vitro against L1210 and P388 leukemias, on DNA, RNA and protein synthesis and showed high inhibition effect. Also increases the frequency of Sister Chromatid Exchanges and reduces the replication index of human lymphocytes.
Catsoulacos
P
P
University of Patras, School of Health and Sciences, Department of Pharmacy, Greece.
Camoutsis
C
C
Papageorgiou
A
A
D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use* / Q000633:toxicity*; D001372:Aza Compounds / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity*; D001378:Azasteroids; D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D005260:Female; D006718:Homosteroids / Q000138:chemical synthesis / Q000627:therapeutic use* / Q000633:toxicity*; D006801:Humans; D007202:Indicators and Reagents; D007939:Leukemia L1210 / Q000188:drug therapy*; D007941:Leukemia P388 / Q000188:drug therapy*; D008214:Lymphocytes / Q000166:cytology / Q000187:drug effects / Q000276:immunology; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D015394:Molecular Structure; D012854:Sister Chromatid Exchange / Q000187:drug effects*; D014407:Tumor Cells, Cultured
C095180:7a,17a-diaza-7,17-dioxo-B,D-dihomo-5-androsten-3-yl 4-N,N-bis(2-chloroethyl)aminophenylacetate; D000970:Antineoplastic Agents; D001372:Aza Compounds; D001378:Azasteroids; D006718:Homosteroids; D007202:Indicators and Reagents