title: A randomized study of the influence of perfusion technique and pH management strategy in 316 patients undergoing coronary artery bypass surgery. II. Neurologic and cognitive outcomes.
abstract: This double-blind, randomized comparison of pulsatile or nonpulsatile perfusion and alpha-stat or pH-stat management during cardiopulmonary bypass was designed to assess postoperative central nervous system outcomes.
  
  
  METHODS
  Neurologic and cognitive testing was conducted before the operation and 7 days and 2 months after the operation in 316 patients having coronary artery bypass and in a reference cohort of 40 patients having major vascular and thoracic operations.
  
  
  RESULTS
  As detailed in part I of this study, mortality in patients having coronary bypass was 2.8%. The incidence of stroke was 2.5% and did not differ among bypass groups. Mortality was 2.5% for the major surgery cohort. The incidence of cognitive (p = 0.003) and either neurologic or cognitive dysfunction (p = 0.0002) was higher at 7 days for the coronary bypass group than for the major surgery cohort. The incidence of neurologic dysfunction remained higher (p = 0.050) at 2 months in the coronary bypass group. Cognitive dysfunction at 2 months was less prevalent after 90 minutes of cardiopulmonary bypass in patients managed with alpha-stat than with pH-stat strategy (27% versus 44%, p = 0.047).
  
  
  CONCLUSIONS
  Postoperative central nervous system dysfunction is more prevalent in patients having coronary bypass than in those having major operations. Pulsatility has no effect on central nervous system outcomes, but alpha-stat management is associated with a decreased incidence of cognitive dysfunction in patients undergoing prolonged cardiopulmonary bypass.
authors.affiliation: Department of Anaesthesia, University Hospital, University of Western Ontario, London, Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Murkin
authors.forename: J S
authors.initials: JS
authors.lastname: Martzke
authors.forename: A M
authors.initials: AM
authors.lastname: Buchan
authors.forename: C
authors.initials: C
authors.lastname: Bentley
authors.forename: C J
authors.initials: CJ
authors.lastname: Wong
mesh_terms: D000368:Aged; D002245:Carbon Dioxide / Q000097:blood*; D002315:Cardiopulmonary Bypass / Q000009:adverse effects / Q000379:methods*; D002493:Central Nervous System Diseases / Q000209:etiology*; D003072:Cognition Disorders / Q000209:etiology*; D001026:Coronary Artery Bypass / Q000009:adverse effects; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008297:Male; D008875:Middle Aged; D011183:Postoperative Complications; D011446:Prospective Studies; D012307:Risk Factors
chemical_list: D002245:Carbon Dioxide