title: New evolution in mitral physiology and surgery: mitral stentless pericardial valve.
abstract: The human adult mitral valve, with a mean diastolic area of up to 7.6 cm2, excess leaflet surface area for coaptation in systole, mitral annulus-papillary muscle continuity, and systolic constriction of the posterior left ventricular wall around the mitral annulus functions in concert with other components of the left side of the heart. Mitral valve replacement with an artificial valve that interferes with the normal physiology could account for less than adequate late results. A stentless biologic mitral valve substitute has been designed, constructed, and tested. The size of the valve is selected according to the circumference of the excised valve within certain limits. The valve is manufactured of two square or trapezoidal pieces of selected stabilized human autologous or bovine pericardium. The pericardial pieces are sutured together by their lateral margins, thus creating a frusto-conical valvular body. The upper circumference of the valvular body is sutured at the mitral annulus and the lower margin with the new chordae is attached by suture at each papillary muscle. In vitro testing of six stentless bovine pericardial valves in a Rowan-Ash fatigue tester at 1,200 cycles/min revealed a durability of more than 320 million cycles. Clinical use of described technique initiated in 1989 was performed in 18 patients by one surgeon (30 patients in the same institution). The mean valve size was 29 mm circularized diameter. There was no mortality in this group of patients up to 70 months of follow-up. Valve competence was obtained in every case by adequate sizing of the valve.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Clinic of Cardiovascular Surgery, Mures Heart Centre, Targu-Mures, Romania.
authors.forename: R F
authors.initials: RF
authors.lastname: Deac
authors.forename: D
authors.initials: D
authors.lastname: Simionescu
authors.forename: D
authors.initials: D
authors.lastname: Deac
mesh_terms: D000293:Adolescent; D000328:Adult; D001705:Bioprosthesis; D015150:Echocardiography, Doppler; D005260:Female; D006350:Heart Valve Prosthesis; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008722:Methods; D008875:Middle Aged; D008943:Mitral Valve / Q000601:surgery*; D011183:Postoperative Complications; D011474:Prosthesis Design