title: Expression and activity-dependent changes of a novel limbic-serine protease gene in the hippocampus.
abstract: A novel murine cDNA which encodes a protein designated neuropsin was cloned. Northern and in situ hybridization analyses demonstrated that neuropsin mRNA is expressed specifically in the limbic system of mouse brain and is localized at highest concentration in pyramidal neurons of the hippocampal CA1-3 subfields. Direct hippocampal stimulation and kindling induced by amygdaloid stimulation caused a significant bilateral change in neuropsin mRNA level in the hippocampal pyramidal neurons. The activity-dependent changes and the specific localization indicate that neuropsin is involved in hippocampal plasticity.
authors.affiliation: Department of Structural Cellular Biology, Nara Institute of Science and Technology (NAIST), Japan.
authors.forename: Z L
authors.initials: ZL
authors.lastname: Chen
authors.forename: S
authors.initials: S
authors.lastname: Yoshida
authors.forename: K
authors.initials: K
authors.lastname: Kato
authors.forename: Y
authors.initials: Y
authors.lastname: Momota
authors.forename: J
authors.initials: J
authors.lastname: Suzuki
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: J
authors.initials: J
authors.lastname: Ito
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: S
authors.initials: S
authors.lastname: Aimoto
authors.forename: H
authors.initials: H
authors.lastname: Kiyama
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D015152:Blotting, Northern; D003001:Cloning, Molecular; D018076:DNA, Complementary / Q000235:genetics; D004558:Electric Stimulation; D015870:Gene Expression; D006624:Hippocampus / Q000502:physiology*; D007610:Kallikreins; D007696:Kindling, Neurologic; D008032:Limbic System / Q000502:physiology*; D051379:Mice; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000378:metabolism; D012697:Serine Endopeptidases / Q000235:genetics* / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D018076:DNA, Complementary; D012333:RNA, Messenger; C094799:KLK8 protein, human; D007610:Kallikreins; D012697:Serine Endopeptidases