Paucity of c-fos expression in the medial preoptic area of prenatally stressed male rats following exposure to sexually receptive females.
Normal male rats display high levels of sexual activity when paired with sexually receptive females, a behavior regulated, in large part, by the medial preoptic area (MPOA). It has been documented that onset of c-fos proteins in the MPOA accompanies sexual behavior. Because prenatal stress (PS) demasculinizes sexual behavior in male rats, the present study examined whether such effects might be accompanied by a decrease in the neuronal activation in MPOA associated with sexual behavior. Adult prenatally stressed (P-S) and unstressed control males were paired with sexually receptive females, and sexual behavior allowed to commence. After a single mount, the pair was separated by a partition for the remainder of an hour, at the end of which the male was killed and the brain processed for c-fos immunocytochemistry; quantification was performed by means of computerized image analysis. P-S males expressed significantly less c-fos activity in the region of the MPOA, compared to nonstressed control males. Thus, the sexual deficits associated with P-S males may be due to a relative dearth of activity in the MPOA at the neuronal level. Coupled to earlier work showing decreased luteinizing hormone secretion in P-S males under similar conditions, the present data suggest a constellation of factors that contribute to PS-induced deficits in sexual behavior.
Humm
J L
JL
Department of Psychology, University of Richmond, VA 23173, USA.
Lambert
K G
KG
Kinsley
C H
CH
D000818:Animals; D005260:Female; D016762:Genes, fos / Q000502:physiology*; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008297:Male; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011301:Preoptic Area / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012733:Sex Differentiation; D012726:Sexual Behavior, Animal / Q000502:physiology*; D013312:Stress, Physiological / Q000378:metabolism*