Monoaminergic control by amygdalar nuclei of the reinforcing action of conditional stimuli.
The influence of microinfusion of 5-HT, NE, and DA into the amygdalar nuclei on the accomplishment of conditioned reinforcing and conditioned trigger reflexes which are constituents of the CADR was studied in cats with a developed conditioned alimentary discrimination reflex (CADR) in response to two conditional light stimuli set apart on different sides of a box. It was established that 5-HT in doses of 30-50 micrograms in a volume of 5 microliters elicits inhibition; the same doses of NE, by contrast, induces the "hanging-up" of the animals on conditional and conditional--unconditional stimuli which possess the property of reinforcement during the execution of the CADR. The microinfusion of DA in doses of 30-60 micrograms recalls, from animal to animal, the action of 5-HT and NE. It is hypothesized that the inhibitory functions of 5-HT and the activating actions of NE in the amygdalar nuclei support this structure's control of reinforcing conditional and conditional--unconditional reflexes and the perception of the reinforcing action of conditional stimuli. It is hypothesized that the DAergic innervation of the amygdala does not participate directly in conditioned reflex activity.
Melikov
E M
EM
A. I. Karaev Institute of Physiology, Academy of Sciences of the Azerbaidzhan, Baku.
Bairamova
E O
EO
D000679:Amygdala / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D000818:Animals; D015306:Biogenic Monoamines / Q000494:pharmacology*; D002415:Cats; D003214:Conditioning, Classical / Q000187:drug effects / Q000502:physiology*; D004193:Discrimination Learning / Q000187:drug effects; D008297:Male; D009638:Norepinephrine / Q000494:pharmacology; D010775:Photic Stimulation; D012055:Reinforcement Schedule; D012701:Serotonin / Q000494:pharmacology
D015306:Biogenic Monoamines; D012701:Serotonin; D009638:Norepinephrine