Chemical modification of tylosin.
20-Homo tylosin, 20-nor tylosin, 20-deoxy-19,20-didehydro tylosin (6-vinyl tylosin) and 2",3"-didehydro-3"-deoxy tylosin were prepared by multi-step procedures. 20-Homo tylosin was about twice less active than tylosin while the other compounds exhibited very weak antibacterial activity.
Bobillot
S
S
Institut de Chimie des Substances Naturelles du C.N.R.S., Gif sur Yvette, France.
Bakos
T
T
Sarda
P
P
Thang
T T
TT
Ming
L
L
Olesker
A
A
Lukacs
G
G
D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D015645:Tylosin / Q000031:analogs & derivatives / Q000737:chemistry*
D000900:Anti-Bacterial Agents; D015645:Tylosin