Regulation of production of tumor necrosis factor alpha in monocytes stimulated by the 30-kilodalton antigen of Mycobacterium tuberculosis.
The 30-kDa secreted antigen of Mycobacterium tuberculosis was a strong inducer of tumor necrosis factor alpha in human monocytes. Our findings suggest that tumor necrosis factor alpha production may be up-regulated at both the posttranscriptional and transcriptional levels. Regulation at the posttranscriptional level probably reflects enhanced translational efficiency.
Averill
L
L
Department of Medicine, Case Western Reserve University, Cleveland, Ohio 44106-4984, USA.
Toossi
Z
Z
Aung
H
H
Boom
W H
WH
Ellner
J J
JJ
D000942:Antigens, Bacterial / Q000737:chemistry / Q000276:immunology*; D006801:Humans; D066298:In Vitro Techniques; D008970:Molecular Weight; D009000:Monocytes / Q000276:immunology*; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D012333:RNA, Messenger / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis* / Q000235:genetics
D000942:Antigens, Bacterial; D012333:RNA, Messenger; D014409:Tumor Necrosis Factor-alpha