Leukocyte kinetics in patients with peritonitis on long-term peritoneal dialysis.
Dialysate and blood leukocyte counts were measured during 130 episodes of peritonitis in 91 hospitalized patients on long-term peritoneal dialysis (CPD). The authors found that the blood/dialysate leukocyte count can be less than 1.0, and this is usually the case when dialysate leukocyte count exceeds 20,000/mm3. Dialysate leukocyte removal in a single 2 L drain bag can approach the leukocyte number in the entire circulating blood volume. Daily drainage can remove leukocytes in amounts exceeding the blood leukocyte pool 2 to 3 fold. The observed blood leukocyte counts throughout a range of 2,700 to 10,000 at dialysate leukocyte counts greater than 20,000 per mm3 may reflect: 1) leukocyte removal approaching maximum bone marrow output of leukocytes, and/or 2) increasing microcirculatory margination of leukocytes in those episodes of peritonitis associated with very high dialysate leukocyte counts.
Vassa
N
N
Division of Nephrology, University of Missouri Health Sciences Center, Dalton Research Center, Columbia 65212, USA.
Nolph
K D
KD
Prowant
B F
BF
Moore
H L
HL
Khanna
R
R
Twardowski
Z J
ZJ
D002478:Cells, Cultured; D003430:Cross-Sectional Studies; D004804:Eosinophils / Q000166:cytology; D004847:Epithelial Cells; D006801:Humans; D007297:Inpatients; D007958:Leukocyte Count; D007962:Leukocytes / Q000166:cytology*; D018655:Lymphocyte Count; D009504:Neutrophils / Q000166:cytology; D010530:Peritoneal Dialysis; D010538:Peritonitis / Q000097:blood* / Q000209:etiology; D013601:T-Lymphocytes / Q000166:cytology