Interferon as an adjuvant treatment for genital condyloma acuminatum.
OBJECTIVE
To evaluate the effect of alpha-interferon as an adjuvant to laser or fluorouracil treatment in patients with recurrent genital human papillomavirus (HPV) infection.


METHODS
Sixty-two females and 21 males were treated for recurrent HPV infection, with either fluorouracil (Efudex 5%) cream or laser ablation of the lesions. Half of the patients were then randomly treated with adjuvant alpha-interferon, to the lesions for patients treated with fluorouracil, or beneath areas previously treated by laser, once a week, for 8 weeks. The other half of the patients did not receive interferon adjuvant. Evaluation of both groups was done using colposcopy and acetic acid, to assess recurrence rates up to 1 year after treatment.


RESULTS
Of the 83 patients followed for 1 year, colposcopy revealed recurrent anogenital lesions in 3 of 45 receiving interferon, compared with 9 of 38 patients treated without adjuvant interferon.


CONCLUSIONS
Interferon is effective as adjuvant treatment in controlling the recurrence of genital HPV.
Klutke
J J
JJ
Department of Obstetrics and Gynecology, Women's and Children's Hospital, USC School of Medicine, Los Angeles, USA.
Bergman
A
A
D000293:Adolescent; D000328:Adult; D003131:Combined Modality Therapy; D003218:Condylomata Acuminata / Q000628:therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage; D005833:Genital Neoplasms, Female / Q000628:therapy*; D005834:Genital Neoplasms, Male / Q000628:therapy*; D006801:Humans; D015552:Injections, Intralesional; D016898:Interferon-alpha / Q000008:administration & dosage*; D053685:Laser Therapy; D008297:Male; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D027383:Papillomaviridae; D030361:Papillomavirus Infections / Q000628:therapy*; D011446:Prospective Studies; D014412:Tumor Virus Infections / Q000628:therapy*
D016898:Interferon-alpha; D005472:Fluorouracil