A randomised, clinical study of the effect of low-dose dopamine on central and renal haemodynamics in infrarenal aortic surgery.
OBJECTIVE
To determine whether dopamine prevents deterioration of central haemodynamics and renal function in aortoiliac surgery.


METHODS
Prospective, randomised and placebo-controlled.


METHODS
University hospital.


METHODS
Thirty patients for elective vascular surgery with implantation of an aortobifemoral or an aortobiiliac graft due to aortoiliac arteriosclerosis had infusion of dopamine 3 micrograms/kg/min or placebo during the operation and 24 h postoperatively. Thoracic epidural analgesia and general anaesthesia were used.


METHODS
Central haemodynamic measurements were registered. The effective renal plasma flow (ERPF), the glomerular filtration rate (GFR), angiotensin II, aldosterone, arginine vasopressin (AVP), atrial natriuretic peptide (ANP), endothelin and excretion of water and electrolytes were measured preoperatively, 1 h postoperatively and 24 h postoperatively.


RESULTS
During the operation the dopamine group had higher cardiac index and heart rate together with lower pulmonary artery wedge blood pressure. ERPF and GFR did not differ between the groups. In the dopamine group ERPF was increased in all patients at the first postoperative clearance. The fractional excretion of sodium, the per- and postoperative diuresis and AVP were increased in the dopamine group as compared to the placebo group. Postoperatively, ANP in the placebo group was raised as compared to the preoperative level.


CONCLUSIONS
Peroperatively, dopamine counteracted depression of left ventricular function. The increased ERPF at the first postoperative clearance in the dopamine group indicates either improved peroperative haemodynamics or a synergistic effect between dopamine and epidural sympathetic blockade. Dopamine also improved diuresis and natriuresis.
de Lasson
L
L
Department of Anaesthesiology, Skejby Hospital, Denmark.
Hansen
H E
HE
Juhl
B
B
Paaske
W P
WP
Pedersen
E B
EB
D000368:Aged; D000450:Aldosterone / Q000097:blood; D000804:Angiotensin II / Q000097:blood; D001012:Aorta, Abdominal / Q000601:surgery*; D001018:Aortic Diseases / Q000503:physiopathology / Q000601:surgery; D001127:Arginine Vasopressin / Q000097:blood; D001161:Arteriosclerosis / Q000503:physiopathology / Q000601:surgery; D009320:Atrial Natriuretic Factor / Q000097:blood; D001807:Blood Vessel Prosthesis; D004298:Dopamine / Q000008:administration & dosage*; D016232:Endothelins / Q000097:blood; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006439:Hemodynamics / Q000187:drug effects*; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D011188:Potassium / Q000652:urine; D011446:Prospective Studies; D017596:Renal Plasma Flow, Effective / Q000187:drug effects; D012964:Sodium / Q000652:urine
D016232:Endothelins; D000804:Angiotensin II; D001127:Arginine Vasopressin; D000450:Aldosterone; D009320:Atrial Natriuretic Factor; D012964:Sodium; D011188:Potassium; D004298:Dopamine