PKR: a new name and new roles.
The double-stranded RNA (dsRNA)-activated protein kinase, now called PKR, was first discovered by virtue of its ability to phosphorylate translation initiation factor eIF-2 and inhibit its activity. Recent studies have shown that expression of inactive mutants of PKR in cultured cells causes them to acquire characteristics typical of transformed cells. These and other findings indicate that PKR plays a role in the normal control of cell growth and differentiation. It seems likely that, in addition to eIF-2, PKR has other substrates including the protein I-kappa B, which regulates the transcription of certain genes. Indeed, it now seems likely that PKR mediates the regulation of selected genes by dsRNA.
Proud
C G
CG
Department of Biochemistry, School of Medical Sciences, University of Bristol, UK.
D004789:Enzyme Activation; D017346:Protein Serine-Threonine Kinases / Q000502:physiology*; D012330:RNA, Double-Stranded / Q000378:metabolism*; D009626:Terminology as Topic; D019892:eIF-2 Kinase
D012330:RNA, Double-Stranded; D017346:Protein Serine-Threonine Kinases; D019892:eIF-2 Kinase