Seizure-protecting effects of kyotorphin and related peptides in an animal model of epilepsy.
Administration of peptides kyotorphin (KT), neokyotorphin (NKT), and d-ser-2-NKT into the lateral brain ventricle (10 nmol) increased the latency and attenuated the severity of picrotoxin-induced convulsions in rats. Anticonvulsive effects of the peptides were also observed after their administration into the CA1 hippocampi (2.5, 5, 10 nmol), with the order of potency d-ser-2-NKT-->NKT-->KT. When injected into the substantia nigra reticulata, the 10 nmol dose of NKT and d-ser-2-NKT displayed equal seizure-protecting effect, which was higher than that for KT. It is concluded that kyotorphin and its analogs provide structure-dependent, dose-dependent, and target site-dependent antiepileptic effect.
Godlevsky
L S
LS
Department of Normal Physiology, Medical Institute, Odessa, Ukraine.
Shandra
A A
AA
Mikhaleva
I I
II
Vastyanov
R S
RS
Mazarati
A M
AM
D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000627:therapeutic use*; D006624:Hippocampus; D007267:Injections; D007276:Injections, Intraventricular; D008297:Male; D010852:Picrotoxin; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D013237:Stereoisomerism; D013378:Substantia Nigra
D000700:Analgesics; D000927:Anticonvulsants; D004723:Endorphins; D010852:Picrotoxin; C019448:kyotorphin; C036450:neo-kyotorphin