title: A review of the evidence that ultraviolet irradiation is a risk factor in cataractogenesis.
abstract: There are two approaches to the question of whether solar radiation contributes to human cataract. The first, epidemiological studies, investigates correlations between man's environmental UV dose and cataract frequency. The second, animal models, investigates the effects of varying UV strengths and spectra on lens opacification in vivo or in vitro. While the latter approach typically provides for direct evidence, the data must still be extrapolated to human lenses. Results of physiological studies suggest that UV photons interact with proteins of the epithelial cell membranes, in particular tryptophan residues, transport ATPases and cytoskeletal proteins. One hypothesis is that damage to ion pumps and channels accumulates over the years as repair processes incompletely restore membrane function. Peroxidative damage is likely in view of the formation of UV-induced lipid peroxides in the lens epithelial membranes. Loss of homeostatic control of ions, particularly Ca++, leads to crystallin disorder in small regions of the underlying fiber cells. In our diabetic cataract studies, intracellular Ca++ electrodes detected large shifts in intracellular Ca++ before bulk-lens changes were apparent. Similar occurrences likely characterize UV cataract. Our lab is one of few studying lens physiology and how it is altered following transient exposures to UV-B and UV-A, both of which pass through the cornea. Some changes include: loss of epithelial cell GSH; elevated Ca++; loss of membrane voltage; impaired transport of Na+; increased permeability to ions and water; inhibition of critical enzymes; and a decrease in the rate of membrane synthesis.
authors.affiliation: Eye Research Institute, Oakland University, Rochester, MI, USA.
authors.forename: K R
authors.initials: KR
authors.lastname: Hightower
mesh_terms: D000818:Animals; D002386:Cataract / Q000209:etiology* / Q000378:metabolism; D002463:Cell Membrane Permeability / Q000528:radiation effects; D004195:Disease Models, Animal; D004848:Epithelium / Q000378:metabolism / Q000528:radiation effects; D006801:Humans; D007908:Lens, Crystalline / Q000378:metabolism / Q000528:radiation effects*; D008054:Lipid Peroxides / Q000378:metabolism; D011833:Radiation Injuries, Experimental / Q000209:etiology* / Q000378:metabolism; D012307:Risk Factors; D014466:Ultraviolet Rays / Q000009:adverse effects*
chemical_list: D008054:Lipid Peroxides