Evaluation of antimuscarinic activity in human volunteers: a teaching aid in clinical pharmacology.
The antimuscarinic activity of oxyphenonium bromide, diphenhydramine hydrochloride and astemizole were evaluated in six volunteers. The parameters used were salivary secretion, heart rate and pupillary size. The results indicated that the changes in heart rate and pupillary size and measurements were not convenient parameters for class room demonstration. However, salivary secretion and dryness of mouth were found to be reliable parameters for measurement. It was concluded that simple procedures like evaluation of antimuscarinic activity could be introduced as teaching aids in clinical pharmacology for undergraduate students.
Tripathi
S K
SK
Department of Pharmacology, Postgraduate Institute of Medical Education and Research, Chandigarh.
Griyappanavar
C R
CR
Lal
A
A
Biswas
K
K
Biswas
N R
NR
Sankaranarayanan
A
A
Sharma
P L
PL
D000328:Adult; D016589:Astemizole / Q000008:administration & dosage / Q000494:pharmacology*; D004155:Diphenhydramine / Q000008:administration & dosage / Q000494:pharmacology*; D004501:Education, Medical / Q000592:standards; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D008297:Male; D018727:Muscarinic Antagonists; D010115:Oxyphenonium / Q000008:administration & dosage / Q000494:pharmacology*; D011680:Pupil / Q000187:drug effects; D012472:Salivation / Q000187:drug effects; D013337:Students, Medical
D018727:Muscarinic Antagonists; D016589:Astemizole; D004155:Diphenhydramine; D010115:Oxyphenonium