[Role of endogenous basic fibroblast growth factor in experimental duodenal ulcer].
Authors investigated the role of endogenous bFGF in the development of experimental duodenal ulcer induced by cysteamine. The changes in endogenous bFGF in duodenum were examined by immunohistochemical method in the early stages of ulceration. A significant decrease was found in the immunoreactivity of bFGF in rat duodenal mucosa 12 and 24 hr after the administration of the duodenal ulcerogen cysteamine. Thus, in addition to being a novel potent pharmacologic agent, bFGF may play a pathophysiologic role in ulcer pathogenesis and healing.
Sándor
Z
Z
Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, Boston, USA.
Kusstatscher
S
S
Sakoulas
G
G
Szabó
S
S
D000818:Animals; D003543:Cysteamine / Q000494:pharmacology; D004381:Duodenal Ulcer / Q000139:chemically induced* / Q000276:immunology; D005260:Female; D016222:Fibroblast Growth Factor 2 / Q000276:immunology* / Q000493:pharmacokinetics; D007150:Immunohistochemistry; D007413:Intestinal Mucosa / Q000187:drug effects / Q000276:immunology; D051381:Rats; D017207:Rats, Sprague-Dawley
D016222:Fibroblast Growth Factor 2; D003543:Cysteamine
Az endogén bázikus fibroblast növekedési faktor szerepe kísérletes duodenális fekélyben.