Cardiotoxicity of parenterally administered iron complexes.
The role of cell calcium overload in the cardiotoxicity of low molecular weight iron complexes has been studied using 45Ca(2+)-uptake determinations in mice intraperitoneally injected with ferric lactate and ferric-ATP complex. Heart tissue shows a very high increase of 45Ca(2+)-uptake which appears to corroborate the hypothesis of cardiotoxicity by calcium overload. ATP seems to play a role in the degree of iron complex efficiency as cell calcium homeostasis modifier.
Anghileri
L J
LJ
Biophysics Laboratory, Medicine Faculty, University of Nancy, France.
Maincent
P
P
Thouvenot
P
P
D000255:Adenosine Triphosphate / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002132:Calcium Radioisotopes; D005260:Female; D005290:Ferric Compounds / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D006331:Heart Diseases / Q000139:chemically induced* / Q000378:metabolism / Q000503:physiopathology; D007273:Injections, Intramuscular; D007274:Injections, Intraperitoneal; D007504:Iron Radioisotopes; D007773:Lactates / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000633:toxicity*; D019344:Lactic Acid; D051379:Mice; D009206:Myocardium / Q000378:metabolism
D002132:Calcium Radioisotopes; D005290:Ferric Compounds; D007504:Iron Radioisotopes; D007773:Lactates; D019344:Lactic Acid; D000255:Adenosine Triphosphate; C045858:ferric-adenosine triphosphate complex; D002118:Calcium