Biochemical studies on the effect of S-1,3-butanediol of diabetes induced rats.
The biochemical effect of S-1,3-butanediol on streptozotocin induced diabetic rats was studied. Rats were made diabetic by the intraperitoneal injection of 40 mg/kg body weight streptozotocin in sodium citrate buffer. A dosage of 25 mmol/kg body weight of S-1,3-butanediol was injected intraperitoneally for treatment. The streptozotocin induced diabetic rats showed a marked increase in blood glucose level, and significant increase in the level of cholesterol, triglycerides and free fatty acids. The glycogen levels in liver and kidney were greatly decreased in diabetic rats. Treatment with butanediol normalised the glucose and glycogen level but had no significant effect on protein and lipid levels.
Meenakshi
C
C
Department of Biochemistry, University of Madras.
Kumari
K L
KL
Devi
C S
CS
D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D001798:Blood Proteins / Q000187:drug effects / Q000378:metabolism; D002072:Butylene Glycols / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D002784:Cholesterol / Q000097:blood; D003921:Diabetes Mellitus, Experimental / Q000097:blood / Q000188:drug therapy*; D004195:Disease Models, Animal; D005230:Fatty Acids, Nonesterified / Q000097:blood; D006003:Glycogen / Q000378:metabolism; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D051381:Rats; D013237:Stereoisomerism; D013311:Streptozocin / Q000008:administration & dosage / Q000633:toxicity; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D001798:Blood Proteins; D002072:Butylene Glycols; D005230:Fatty Acids, Nonesterified; D014280:Triglycerides; C028491:1,3-butylene glycol; D013311:Streptozocin; D006003:Glycogen; D002784:Cholesterol