Evidence that dietary arachidonic acid increases circulating triglycerides.
Male Syrian hamsters and male CD-1 mice were fed diets supplemented with ethyl esters of oleic, linoleic, arachidonic, and eicosapentaenoic acids (1.1-5%, w/w) for 3-4 wk. Plasma and serum triglycerides were significantly higher in the arachidonic acid-supplemented animals compared to those in the other supplementation groups. Changes in serum insulin and glucose levels did not appear to be related to the changes in circulating triglycerides observed in the arachidonic acid-supplemented group. These data indicate that dietary arachidonic acid elevates circulating triglyceride levels compared to other unsaturated fatty acids in hamsters and mice by unknown mechanisms.
Whelan
J
J
Department of Nutrition, University of Tennessee, Knoxville 37996-1900, USA.
Surette
M E
ME
Li-Stiles
B
B
Bailey
J W
JW
D000818:Animals; D016718:Arachidonic Acid / Q000008:administration & dosage / Q000009:adverse effects*; D001786:Blood Glucose / Q000378:metabolism; D006224:Cricetinae; D004042:Dietary Fats, Unsaturated / Q000008:administration & dosage / Q000009:adverse effects*; D015118:Eicosapentaenoic Acid / Q000008:administration & dosage; D015525:Fatty Acids, Omega-3 / Q000008:administration & dosage; D007328:Insulin / Q000097:blood; D008297:Male; D008647:Mesocricetus; D051379:Mice; D014280:Triglycerides / Q000097:blood*
D001786:Blood Glucose; D004042:Dietary Fats, Unsaturated; D015525:Fatty Acids, Omega-3; D007328:Insulin; D014280:Triglycerides; D016718:Arachidonic Acid; D015118:Eicosapentaenoic Acid