title: Primary angiosarcoma of the spleen: a case report and review of the literature.
abstract: We describe a 47-year-old man with shoulder pain, multiple bony lesions, and a 1-cm lesion in the spleen. T-1 facetectomy revealed a poorly differentiated malignant neoplasm. Several months after chemotherapy, multiple splenic lesions were found by computed tomography and liver-spleen scan. A splenectomy showed a malignant spindle-cell neoplasm forming irregular vascular spaces. Tumor cells were positive for factor VIII-related antigen and vimentin. This patient died of extensive metastases from this primary angiosarcoma of the spleen. Splenic angiosarcoma is a rare neoplasm that often has a cryptic presentation and a dismal prognosis.
authors.affiliation: Department of Pathology, University of Tennessee Medical Center at Knoxville 37920, USA.
authors.forename: K
authors.initials: K
authors.lastname: McGinley
authors.forename: P
authors.initials: P
authors.lastname: Googe
authors.forename: W
authors.initials: W
authors.lastname: Hanna
authors.forename: J
authors.initials: J
authors.lastname: Bell
mesh_terms: D006394:Hemangiosarcoma / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged; D013156:Splenectomy; D013160:Splenic Neoplasms / Q000000981:diagnostic imaging / Q000473:pathology* / Q000601:surgery; D014057:Tomography, X-Ray Computed