Enhancement in gastric mucosal EGF and PDGF receptor expression with ulcer healing by sulglycotide.
1. The effect of an antiulcer agent, sulglycotide, on mucosal expression of EGF and PDGF receptors with chronic ulcer healing was investigated. 2. Rats with experimentally-induced gastric ulcers were treated twice daily for 14 consecutive days, either with sulglycotide at 200 mg/kg or vehicle, and at different stages of treatment used for quantitation of gastric mucosal EGF and PDGF receptors. 3. The ulcer healing was accompanied by an increase in mucosal expression of both types of receptors. A 1.8-fold increase in EGF and 3.1-fold increase in PDGF receptors occurred by the 4th day following the development of ulcer and reached a maximum of 2.4-3.9-fold increase by the 10-14th day. 4. Treatment with sulglycotide caused accelerated ulcer healing accompanied by a significant enhancement in the receptors expression. A 2.3- and 3.6-fold increase in EGF and PDGF receptor expression occurred by the 4th day of sulglycotide treatment, reaching a 5.5- and 5.6-fold respective increase by the 10th day when the ulcer essentially healed. 5. The results attest to the ability of sulglycotide to stimulate the gastric mucosal proliferative activities associated with ulcer healing.
Piotrowski
J
J
Research Center, University of Medicine and Dentistry of New Jersey, Newark 07103-2400, USA.
Majka
J
J
Sano
S
S
Nowak
P
P
Murty
V L
VL
Slomiany
A
A
Slomiany
B L
BL
D000085:Acetates; D019342:Acetic Acid; D000818:Animals; D000897:Anti-Ulcer Agents / Q000627:therapeutic use*; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D002908:Chronic Disease; D066246:ErbB Receptors / Q000096:biosynthesis*; D005753:Gastric Mucosa / Q000378:metabolism* / Q000473:pathology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017479:Receptors, Platelet-Derived Growth Factor / Q000096:biosynthesis*; D012795:Sialoglycoproteins / Q000627:therapeutic use*; D013276:Stomach Ulcer / Q000188:drug therapy* / Q000378:metabolism* / Q000473:pathology
D000085:Acetates; D000897:Anti-Ulcer Agents; D012795:Sialoglycoproteins; C009354:sulglicotide; D066246:ErbB Receptors; D017479:Receptors, Platelet-Derived Growth Factor; D019342:Acetic Acid