title: Preliminary investigation of ultrasound scattering analysis to identify women at risk for later invasive cancer. I: Motivation and experimental technique for characterization of isolated breast tissue lobules.
abstract: A new experimental technique is described that allows the characterization of the angle-dependent ultrasonic scattering properties of isolated breast tissue lobules. A review of breast tissue micro-architecture is presented as background material. Measured estimates of the scatter angle-dependent differential scatter cross-sections (DSC) from 31 excised lobules (14 cancer in situ, 17 noncancer) were examined, and dominant trends described by statistical factors. Three factors were extracted, using principal component factor analysis, which collectively accounted for over 70% of the scatter angle-dependent variation exhibited by the measured data.
authors.affiliation: Advanced Technology Laboratories, Bothell, WA 98041-3003, USA.
authors.forename: T M
authors.initials: TM
authors.lastname: Burke
authors.forename: T A
authors.initials: TA
authors.lastname: Blankenberg
authors.forename: A K
authors.initials: AK
authors.lastname: Siu
authors.forename: F G
authors.initials: FG
authors.lastname: Blankenberg
authors.forename: H M
authors.initials: HM
authors.lastname: Jensen
mesh_terms: D001943:Breast Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D002278:Carcinoma in Situ / Q000000981:diagnostic imaging* / Q000473:pathology; D018275:Carcinoma, Lobular / Q000000981:diagnostic imaging* / Q000473:pathology; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D010865:Pilot Projects; D012307:Risk Factors; D016217:Ultrasonography, Mammary / Q000379:methods*