Tyrphostins suppress the growth of psoriatic keratinocytes.
Tyrosine kinase inhibitors of the tyrphostin family which block EGF receptor kinase are reported to arrest the growth of psoriatic keratinocytes in vitro. Three tyrphostins with the potency ratio AG555 >> AG18 >> AG814 were found to arrest growth with no adverse cytotoxic effects. The potency ratio to inhibit keratinocyte proliferation follows their potency to inhibit EGF receptor kinase activity in vitro. These compounds represent novel leads for the therapy of psoriasis.
Ben-Bassat
H
H
Laboratory of Experimental Surgery, Hadassah University Hospital, Jerusalem, Israel.
Vardi
D V
DV
Gazit
A
A
Klaus
S N
SN
Chaouat
M
M
Hartzstark
Z
Z
Levitzki
A
A
D001597:Benzylidene Compounds / Q000494:pharmacology*; D002396:Catechols / Q000494:pharmacology*; D002478:Cells, Cultured / Q000187:drug effects; D003879:Dermatologic Agents / Q000494:pharmacology*; D066246:ErbB Receptors / Q000037:antagonists & inhibitors*; D005260:Female; D006801:Humans; D015603:Keratinocytes / Q000187:drug effects*; D008297:Male; D009570:Nitriles / Q000494:pharmacology*; D011565:Psoriasis / Q000473:pathology*; D020794:Receptor Protein-Tyrosine Kinases / Q000037:antagonists & inhibitors*; D020032:Tyrphostins
D001597:Benzylidene Compounds; D002396:Catechols; D003879:Dermatologic Agents; D009570:Nitriles; D020032:Tyrphostins; C095713:alpha-cyano-(3,4-dihydroxy)-N-(3-phenylpropyl)cinnamide; C095124:tyrphostin AG 814; D066246:ErbB Receptors; D020794:Receptor Protein-Tyrosine Kinases; C060641:tyrphostin A23