The metabotropic glutamate receptors: structure and functions.
Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via specific receptors coupled to G-proteins. The existence of these receptors, called metabotropic glutamate receptors, is changing our views on the functioning of fast excitatory synapses.
Pin
J P
JP
UPR-CNRS 9023, Centre CNRS-INSERM de Pharmacologie-Endocrinologie, Montpellier, France.
Duvoisin
R
R
D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D015220:Calcium Channels; D003001:Cloning, Molecular; D006152:Cyclic GMP; D019204:GTP-Binding Proteins; D018698:Glutamic Acid / Q000494:pharmacology*; D006801:Humans; D008969:Molecular Sequence Data; D018377:Neurotransmitter Agents / Q000737:chemistry / Q000502:physiology*; D018094:Receptors, Metabotropic Glutamate / Q000737:chemistry / Q000235:genetics / Q000502:physiology*
D015220:Calcium Channels; D018377:Neurotransmitter Agents; D018094:Receptors, Metabotropic Glutamate; D018698:Glutamic Acid; D019204:GTP-Binding Proteins; D006152:Cyclic GMP