Control of myocardial reperfusion injury with hypertonic-hyperosmotic solution in isolated rabbit heart.
The effects of postischemic reperfusion were investigated in 14 isolated rabbit hearts in Langendorff preparation. Seven were controls and the others were reperfused with a sodium 7.5% and dextran 60 (60,000 MW) solution diluted with Krebs-Henseleit buffer to a sodium concentration of 150 mEq/l. The incidence of arrhythmias was lower in this group (p = 0.034). Coronary flow was higher than in controls (p = 0.035), the levels of isoenzyme MB of creatine kinase were lower than in controls (p = 0.035), myocardial water content was also lower (p = 0.047), and histological damage was reduced (p = 0.018). It was concluded that early reperfusion with 7.5% sodium chloride, 6% dextran 60 solution has a protective effect in the treatment of cardiac reperfusion injury.
Careaga
G
G
Hospital de Cardiologia, Centro Medico Nacional Siglo, XXI, IMSS, Mexico, D.F., Mexico.
Argüero
R
R
Chavez-Negrete
A
A
Valero
G
G
Portilla
E
E
Garcia
R M
RM
Mendoza
L
L
Angulo
L
L
Miranda
Y
Y
D000818:Animals; D001145:Arrhythmias, Cardiac / Q000453:epidemiology / Q000209:etiology; D001834:Body Water / Q000378:metabolism; D003326:Coronary Circulation; D003402:Creatine Kinase; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006982:Hypertonic Solutions / Q000494:pharmacology*; D066298:In Vitro Techniques; D015994:Incidence; D007527:Isoenzymes; D015428:Myocardial Reperfusion Injury / Q000150:complications / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009994:Osmolar Concentration; D011817:Rabbits
D006982:Hypertonic Solutions; D007527:Isoenzymes; D003402:Creatine Kinase