title: [Morpho-functional diagnostic imaging in the assessment of viable myocardium in patients with ischemic heart disease. Correlations between myocardial perfusion and regional function of the left ventricle].
abstract: Forty patients (38 men and 2 women, mean age 56 +/- 9 years) with angiographic evidence of coronary artery disease underwent 201Thallium myocardial scintigraphy and two-dimensional echocardiography. 201Thallium uptake and echocardiographic regional ventricular function were studied in corresponding myocardial segments. On exercise-redistribution 201Thallium imaging, 308 segments (51% of the total) had normal Thallium uptake, 48 (8%) exhibited reversible defects and 244 (41%) irreversible defects. Of the latter 244 segments with irreversible defects, 114 (47%) exhibited increased tracer uptake (Re+) and 130 (53%) remained unchanged (Re-) after 201Thallium reinjection at rest. Regional ventricular function was significantly better in the segments with normal Thallium uptake than in the segments with reversible or irreversible defects (p < 0.001). Furthermore, the segments with irreversible defects Re- had impaired regional function compared to the segments with irreversible defects Re+ (p < 0.001). Coronary artery stenosis was significantly more severe in the segments with irreversible defects Re- (93 +/- 16%) than in those with reversible defects (81 +/- 20%) and with irreversible Re+ defects (80 +/- 20%) (both p < 0.001). In conclusion, in coronary artery disease patients, exercise-redistribution 201Thallium cardiac imaging with reinjection at rest can identify severely ischemic but still viable myocardium and may be particularly useful in the prognosis of such patients.
authors.affiliation: Istituto di Scienze Radiologiche, Università Federico II, Napoli.
authors.forename: A
authors.initials: A
authors.lastname: Cuocolo
authors.forename: L
authors.initials: L
authors.lastname: Pace
authors.forename: S
authors.initials: S
authors.lastname: Maurea
authors.forename: A
authors.initials: A
authors.lastname: Nappi
authors.forename: E
authors.initials: E
authors.lastname: Nicolai
authors.forename: M
authors.initials: M
authors.lastname: Imbriaco
authors.forename: P
authors.initials: P
authors.lastname: Sullo
authors.forename: S
authors.initials: S
authors.lastname: Cardei
authors.forename: M
authors.initials: M
authors.lastname: Salvatore
mesh_terms: D000328:Adult; D000368:Aged; D004452:Echocardiography; D005260:Female; D015637:Gated Blood-Pool Imaging / Q000379:methods; D006801:Humans; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000175:diagnosis / Q000503:physiopathology*; D010477:Perfusion; D016277:Ventricular Function, Left / Q000502:physiology*
vernacular_title: Diagnostica per immagini morfo-funzionale nella valutazione del miocardio vitale in pazienti con cardiopatia ischemica. Correlazioni tra perfusione miocardica e funzione regionale del ventricolo sinistro.