[The effect of nicorandil on the neuromuscular block induced by vecuronium].
The effect of nicorandil on the neuromuscular block induced by vecuronium was investigated in vitro with rat phrenic nerve-hemidiaphragm preparation. Both single twitch (ST) and train-of-four ratio (TOFR) elicited with indirect electrical stimulation were used. The administration of nicorandil alone showed no effects on ST and TOFR. The pre-administration of nicorandil exerted significant depressing effect on ST compared with vecuronium alone. High concentration of nicorandil (4 x 10(-6) M) produced more significant effect on ST compared with low concentration of nicorandil (10(-7) M). In this study, the nicorandil showed similar effect as calcium antagonists on neuromuscular blockade.
Oyanagi
S
S
Department of Anesthesiology, Kanazawa Medical University, Ishikawa.
Matsuda
T
T
Abe
H
H
Mori
H
H
D000818:Animals; D004558:Electric Stimulation; D008297:Male; D009466:Neuromuscular Blocking Agents / Q000494:pharmacology*; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000494:pharmacology; D020108:Nicorandil; D010791:Phrenic Nerve / Q000187:drug effects; D051381:Rats; D014673:Vecuronium Bromide / Q000494:pharmacology*
D009466:Neuromuscular Blocking Agents; D009536:Niacinamide; D020108:Nicorandil; D014673:Vecuronium Bromide