Activation of GABA-A receptor by hypotensive drugs.
Chronic antihypertensive treatment with clonidine and beta-adrenoceptor blockers leads to a significant increase in GABA-A receptor number in the hypothalamus, the pons-medulla and the striatum. The enhancement of receptor number after two beta-blockers was associated with the decrease of Kd factor in the pons-medulla and the striatum. There was no change in receptor affinity after clonidine. We conclude that neurotransmission via GABA-A receptors is important for the hypotensive effects of clonidine and some beta-adrenoceptor blockers.
Remiszewska
M
M
Department of Pharmacology, Drug Institute, Warsaw, Poland.
Jastrzebski
Z
Z
Czyzewska-Szafran
H
H
Skierski
J S
JS
D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004334:Drug Administration Schedule; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*
D000959:Antihypertensive Agents; D011963:Receptors, GABA-A