title: Secondary organ allografting after a primary "bridging" xenotransplant.
abstract: It remains uncertain whether xenotransplantation can sensitize the recipient to alloantigens, rendering subsequent allotransplantation unsuccessful. This is of considerable importance if a xenograft is to be used as a "bridge" to support the patient until a suitable allograft becomes available. When sera from 9 baboons that had received pig or African green monkey heart or liver xenografts were tested against a panel of lymphocytes from 5 or 6 potential donor baboons, positivity was seen in only 1 baboon (and then to only 2 of the potential 5 donors). In 4 baboons that had undergone previous xenotransplants (1 from this series of 9 baboons and 3 others), subsequent organ allografting was not followed by hyperacute, antibody-mediated, or accelerated cellular rejection. We conclude that organ xenotransplantation using discordant or concordant donor species does not prohibit subsequent allotransplantation.
authors.affiliation: Oklahoma Transplantation Institute, Oklahoma University Health Sciences Center, Oklahoma City 73112, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Ye
authors.forename: Y
authors.initials: Y
authors.lastname: Luo
authors.forename: T
authors.initials: T
authors.lastname: Kobayashi
authors.forename: S
authors.initials: S
authors.lastname: Taniguchi
authors.forename: S
authors.initials: S
authors.lastname: Li
authors.forename: M
authors.initials: M
authors.lastname: Niekrasz
authors.forename: S
authors.initials: S
authors.lastname: Kosanke
authors.forename: J
authors.initials: J
authors.lastname: Baker
authors.forename: L
authors.initials: L
authors.lastname: Mieles
authors.forename: D
authors.initials: D
authors.lastname: Smith
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D006084:Graft Rejection / Q000517:prevention & control; D006085:Graft Survival / Q000276:immunology; D016027:Heart Transplantation / Q000276:immunology*; D006650:Histocompatibility Testing; D007519:Isoantigens / Q000276:immunology*; D016031:Liver Transplantation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D010215:Papio; D013552:Swine; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
chemical_list: D007519:Isoantigens