title: Relationship of haptoglobin polymorphism to malaria in the Solomon Islands.
abstract: Haptoglobin (Hp) polymorphism and its relationship to malaria infections was examined in Solomon Islanders under 25 years of age. The slide positive rate for malaria was 48% (53/111): Plasmodium vivax (Pv) 21 cases, Plasmodium falciparum (Pf) 16 cases and the remaining 16 were a mixture of Pv/Pf/P. malariae. Of 111 subjects examined, 17% (19 subjects) were ahaptoglobinemic (HpO). No association was observed between HpO and parasitemia, gender, anemia, serum insulin-like growth factor-1 (IGF-1) level, blood glucose level and enlargement of the spleen. These results suggest that malaria may not be the major cause of HpO in the people of the Solomon Islands.
authors.affiliation: First Department of Internal Medicine, Toyama Medical and Pharmaceutical University.
authors.forename: Y
authors.initials: Y
authors.lastname: Mizushima
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: H
authors.initials: H
authors.lastname: Ohmae
authors.forename: T
authors.initials: T
authors.lastname: Tanaka
authors.forename: A
authors.initials: A
authors.lastname: Bobogare
authors.forename: A
authors.initials: A
authors.lastname: Ishii
mesh_terms: D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006242:Haptoglobins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008288:Malaria / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008542:Melanesia / Q000453:epidemiology; D018512:Parasitemia / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D012424:Rural Population
chemical_list: D000962:Antimalarials; D001786:Blood Glucose; D006242:Haptoglobins; D007334:Insulin-Like Growth Factor I