[Expression of E-cadherin in thyroid neoplastic tissues and its correlation with malignant and metastatic potential].
Cadherin is an Ca2+ dependent adhesion molecules, which contribute to cell-cell adhesion and maintenance of tissue structures. Its decrease or functional abnormality plays an important vole in cancer invasion and metastasis. We investigate the expression of E- cadherin in thyroid neoplasms (papillary cancer, follicular cancer, medullary cancer anaplastic cancer and follicular adenoma) and normal thyroid. The decrease of E-cadherin expression in thyroid cancer correlates with its malignancy and metastatic potentiality.
Naitoh
A
A
2nd Department of Surgery, Nagoya City University Medical School.
Kobayashi
S
S
Iwase
H
H
Kuzushima
T
T
D018263:Adenocarcinoma, Follicular / Q000737:chemistry / Q000473:pathology; D000236:Adenoma / Q000737:chemistry / Q000473:pathology; D000328:Adult; D015820:Cadherins / Q000032:analysis*; D018276:Carcinoma, Medullary / Q000737:chemistry / Q000473:pathology; D002291:Carcinoma, Papillary / Q000737:chemistry / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009362:Neoplasm Metastasis; D013964:Thyroid Neoplasms / Q000737:chemistry* / Q000473:pathology*
D015820:Cadherins