Growth phase in relation to the lethal action of tamoxifen on Candida albicans.
Tamoxifen, a drug used to treat breast cancer, might have antifungal potential. The fungicidal activity of tamoxifen against Candida albicans surpassed that of the most active of the imidazole-type drugs. At 15-20 microM, tamoxifen rapidly killed yeast cells in stationary phase as well as in logarithmic phase, whereas imidazoles at this level generally do not exert significant lethal activity against stationary phase organisms.
Beggs
W H
WH
VA Medical Center, Minneapolis, MN 55417, USA.
D002176:Candida albicans / Q000187:drug effects / Q000254:growth & development*; D008826:Microbial Sensitivity Tests; D013629:Tamoxifen / Q000494:pharmacology*; D013997:Time Factors
D013629:Tamoxifen