Disseminated Mycobacterium avium--intracellulare complex infection in a miniature schnauzer.
A two-year-old, spayed female, miniature schnauzer was evaluated for respiratory distress associated with a compressive cervical mass. Generalized mycobacterial infection was diagnosed from aspirates of several enlarged lymph nodes. Tissue specimens further identified Mycobacterium avium--intracellulare using polymerase chain reaction followed by nucleic acid hybridization. Treatment with enrofloxacin, clofazamine, rifampin, and interferon did not result in long-term success.
Miller
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MA
Department of Small Animal Medicine, College of Veterinary Medicine, University of Georgia, Athens 30602, USA.
Greene
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CE
Brix
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D000818:Animals; D000890:Anti-Infective Agents; D002991:Clofazimine / Q000627:therapeutic use; D004269:DNA, Bacterial / Q000032:analysis; D004283:Dog Diseases / Q000175:diagnosis* / Q000188:drug therapy / Q000382:microbiology; D004285:Dogs; D000077422:Enrofloxacin; D005260:Female; D024841:Fluoroquinolones; D016898:Interferon-alpha / Q000627:therapeutic use; D008198:Lymph Nodes / Q000382:microbiology / Q000473:pathology; D008334:Mandible; D008643:Mesentery; D009162:Mycobacterium avium / Q000187:drug effects / Q000235:genetics / Q000302:isolation & purification*; D009693:Nucleic Acid Hybridization; D016133:Polymerase Chain Reaction / Q000662:veterinary; D015363:Quinolones / Q000627:therapeutic use; D012293:Rifampin / Q000627:therapeutic use; D014376:Tuberculosis / Q000175:diagnosis / Q000188:drug therapy / Q000382:microbiology / Q000662:veterinary*
D000890:Anti-Infective Agents; D004269:DNA, Bacterial; D024841:Fluoroquinolones; D016898:Interferon-alpha; D015363:Quinolones; D000077422:Enrofloxacin; D002991:Clofazimine; D012293:Rifampin