title: The use of 25% glutaraldehyde solution to strengthen the aorta of patients with annuloaortic ectasia, ascending and aortic arch aneurysms.
abstract: Aortic friability is a problem of great concern and frustration for those performing operations on patients with ascending and arch aortic aneurysms, and particularly, on patients with annuloaortic ectasia. We have used 25% glutaraldehyde to successfully strengthen the distal aorta of three such patients. After the application, the aorta wall held sutures without tearing. Postoperative bleeding was minimal in each case. No neurological events were noticed, and all of the patients were discharged home within 2 weeks. The application of this tanning solution to such a friable aortic tissue should be considered as a helpful alternative to reduce postoperative bleeding, which is the most common complication after this type of surgery.
authors.affiliation: Cardiovascular Institute, Pavia Hospital, San Juan, Puerto Rico.
authors.forename: R G
authors.initials: RG
authors.lastname: Rinaldi
authors.forename: J
authors.initials: J
authors.lastname: Carballido
authors.forename: J
authors.initials: J
authors.lastname: Mojica
authors.forename: E A
authors.initials: EA
authors.lastname: Almodovar
mesh_terms: D000368:Aged; D001011:Aorta / Q000187:drug effects*; D001014:Aortic Aneurysm / Q000188:drug therapy* / Q000601:surgery; D017545:Aortic Aneurysm, Thoracic / Q000188:drug therapy* / Q000601:surgery; D001018:Aortic Diseases / Q000188:drug therapy* / Q000601:surgery; D005260:Female; D005976:Glutaral / Q000494:pharmacology / Q000627:therapeutic use*; D006801:Humans; D008297:Male
chemical_list: D005976:Glutaral