title: Bupropion/nortriptyline combination for refractory depression.
abstract: Many patients fail to respond to one or more trials with a single antidepressant. In such cases polypharmacy is often necessary and beneficial, although there may be an increased risk of complications. Four case reports are presented of patients with refractory depression treated successfully with the combination of the tricyclic antidepressant nortriptyline and the newer agent bupropion.
authors.affiliation: Department of Psychology, Rutgers University, New Brunswick, New Jersey, USA.
authors.forename: J T
authors.initials: JT
authors.lastname: Apter
authors.forename: S F
authors.initials: SF
authors.lastname: Kushner
authors.forename: R L
authors.initials: RL
authors.lastname: Woolfolk
mesh_terms: D016642:Bupropion / Q000008:administration & dosage* / Q000009:adverse effects; D003866:Depressive Disorder / Q000188:drug therapy* / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009661:Nortriptyline / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D016642:Bupropion; D009661:Nortriptyline