title: Effect of piroxicam beta-cyclodextrin complex on experimental inflammation.
abstract: 1. The effectiveness of the inclusion product of piroxicam with beta-cyclodextrin was compared to that of free piroxicam on inflammatory reactions by using three experimental inflammatory models in rats. 2. The inclusion compound showed anti-inflammatory effects similar to those of simple piroxicam on granuloma tissue formation and arthritis induced by complete Freund adjuvant. 3. In carrageenin-induced pleurisy, the piroxicam beta-cyclodextrin reduced leukocyte mobilization more intensely than non-complexed piroxicam. 4. These results suggest that beta-cyclodextrin is a useful tool for improving the efficacy of piroxicam.
authors.affiliation: Depto. de Farmácia e Farmacologia, Universidade de Maringá, Paraná, Brazil.
authors.forename: C A
authors.initials: CA
authors.lastname: Amado
authors.forename: S F
authors.initials: SF
authors.lastname: Taniguchi
authors.forename: L S
authors.initials: LS
authors.lastname: Sudo
authors.forename: E
authors.initials: E
authors.lastname: Kimura
authors.forename: S
authors.initials: S
authors.lastname: Oga
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan; D003505:Cyclodextrins / Q000494:pharmacology*; D005620:Freund's Adjuvant; D003368:Gossypium; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D010894:Piroxicam / Q000494:pharmacology*; D010998:Pleurisy / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D047392:beta-Cyclodextrins
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D010894:Piroxicam; D002351:Carrageenan; D005620:Freund's Adjuvant; C031215:betadex