Discriminant function using red cell indices to distinguish between HbC and HbE traits.
Values for MCV, MCH, MCHC and red cell distribution width (RDW) derived from subjects with HbC and HbE traits using a Technicon H*1 automated blood count analyser were compared. Significantly higher MCH, MCHC and RDW values were found in those with HbC trait. By use of a simple discriminant function (MCHC2 x RDW/1000), 19/20 subjects with HbC trait gave a value > or = 16.3, and 20/21 subjects with HbE trait gave a value < or = 16.2. The function described may be of value as an adjunct to electrophoresis in intralaboratory quality control.
Hinchliffe
R F
RF
Section of Paediatric Haematology, University of Sheffield Department of Paediatrics, Children's Hospital, Western Bank, UK.
Ellis
S P
SP
Lilleyman
J S
JS
D000328:Adult; D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D004909:Erythrocyte Indices; D005260:Female; D006444:Hemoglobin C / Q000032:analysis* / Q000235:genetics; D006446:Hemoglobin E / Q000032:analysis* / Q000235:genetics; D006456:Hemoglobinuria / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male
D006444:Hemoglobin C; D006446:Hemoglobin E