Follow up of growth and steroids in premature adrenarche.
In a follow up study of 34 patients with premature adrenarche we examined serum adrenal androgen levels and growth. The majority (28/34) showed an upward bend in the growth curve which, at the mean age of 2.3 years, preceded other signs of adrenarche on average by 3.8 years. Pubertal growth spurt was missing or reduced in 50% of the patients (8/16), however, final height did not differ from that expected from parental heights. Adrenal androgens did not remain elevated at adolescence. The mean age at menarche for all the girls was 0.5 years younger than in the general population.


CONCLUSIONS
Our findings imply that premature adrenarche may start earlier than previously recognized. Compared to ordinary growth these children seem to use a greater part of their potential for adult height already at that early age.
Pere
A
A
Children's Hospital, University of Helsinki, Finland.
Perheentupa
J
J
Peter
M
M
Voutilainen
R
R
D000293:Adolescent; D000311:Adrenal Glands / Q000378:metabolism*; D000328:Adult; D000728:Androgens / Q000378:metabolism*; D001827:Body Height; D002648:Child; D005260:Female; D005387:Finland; D005500:Follow-Up Studies; D006128:Growth; D006801:Humans; D008297:Male; D008572:Menarche; D011627:Puberty / Q000097:blood*; D011629:Puberty, Precocious / Q000097:blood / Q000503:physiopathology*; D012015:Reference Standards
D000728:Androgens