title: A non-ionic water-soluble pentaphyrin derivative. Synthesis and cytotoxicity.
abstract: The synthesis of the water soluble tetrahydroxypentaphyrin derivative, 1, is described. This species, which forms complexes with both small neutral molecules and uranyl cation, has been studied as a possible cytotoxic agent. Cytotoxic studies performed with the human T lymphoma cell line (JURKAT) revealed that pentaphyrin 1 exhibits toxicity at microM concentrations comparable with other water soluble, porphyrin-type systems such as the pyridinium metalloporphyrins.
authors.affiliation: Department of Chemistry and Biochemistry, University of Texas at Austin 78712, USA.
authors.forename: V
authors.initials: V
authors.lastname: Král
authors.forename: E A
authors.initials: EA
authors.lastname: Brucker
authors.forename: G
authors.initials: G
authors.lastname: Hemmi
authors.forename: J L
authors.initials: JL
authors.lastname: Sessler
authors.forename: J
authors.initials: J
authors.lastname: Králová
authors.forename: H
authors.initials: H
authors.lastname: Bose
mesh_terms: D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011166:Porphyrins / Q000138:chemical synthesis / Q000494:pharmacology*; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water
chemical_list: D000970:Antineoplastic Agents; D011166:Porphyrins; D014867:Water