title: Alpha-globin gene haplotypes in South American Indians.
abstract: The haplotypes of the alpha-globin gene cluster were determined for 99 Indians from the Brazilian Amazon region who belong to 5 tribes: Wayampí, Wayana-Apalaí, Kayapó, Arára, and Yanomámi. Three predominant haplotypes were identified: Ia (present in 38.9% of chromosomes), IIIa (25.8%), and IIe (22.1%). The only alpha-globin gene rearrangement detected was alpha alpha alpha 3.7 I gene triplication associated with haplotype IIIa, found in high frequencies (5.6% and 10.6%) in two tribes and absent in the others. alpha-Globin gene deletions that cause alpha-thalassemia were not seen, supporting the argument that malaria was absent in these populations until recently. The heterogeneous distribution of alpha-globin gene haplotypes and rearrangements among the different tribes differs markedly from the homogeneous distribution of beta-globin gene cluster haplotypes and reflects the action of various genetic mechanisms (genetic drift, founder effect, consanguinity) on small isolated population groups with a complicated history of divergence-fusion events. The alpha-globin gene haplotype distribution has some similarities to distributions observed in Southeast Asian and Pacific Island populations, indicating that these populations have considerable genetic affinities. However, the absence of several features of the alpha-globin gene cluster that are consistently present among the Pacific Islanders suggests that the similarity of haplotypes between Brazilian Indians and people from Polynesia, Micronesia, and Melanesia is more likely to result of ancient common ancestry rather than the consequence of recent direct genetic contribution through immigration.
authors.affiliation: Department of Clinical Medicine, School of Medicine, Ribeirão Preto, Brazil.
authors.forename: M A
authors.initials: MA
authors.lastname: Zago
authors.forename: E J
authors.initials: EJ
authors.lastname: Melo Santos
authors.forename: J B
authors.initials: JB
authors.lastname: Clegg
authors.forename: J F
authors.initials: JF
authors.lastname: Guerreiro
authors.forename: J J
authors.initials: JJ
authors.lastname: Martinson
authors.forename: J
authors.initials: J
authors.lastname: Norwich
authors.forename: M S
authors.initials: MS
authors.lastname: Figueiredo
mesh_terms: D000483:Alleles; D001483:Base Sequence; D001938:Brazil; D005787:Gene Frequency; D015321:Gene Rearrangement; D005914:Globins / Q000235:genetics*; D006239:Haplotypes / Q000235:genetics*; D006801:Humans; D007199:Indians, South American / Q000235:genetics*; D008969:Molecular Sequence Data
chemical_list: D005914:Globins