Patellamide F, A new cytotoxic cyclic peptide from the colonial ascidian Lissoclinum patella.
Cytotoxicity-directed fractionation of an organic extract of the tunicate Lissoclinum patella afforded a new cyclic octapeptide, patellamide F [1]. The structure and absolute stereochemistry of 1 were established by a combination of spectroscopic and chemical methods. Three known cyclic peptides, patellamide B [2], ulithiacyclamide, and lissoclinamide 3, were also isolated and identified.
Rashid
M A
MA
Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
Gustafson
K R
KR
Cardellina
J H
JH
Boyd
M R
MR
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D010126:Ozone / Q000737:chemistry; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured; D014561:Urochordata / Q000737:chemistry*
D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C094789:patellamide F; D010126:Ozone