The isolation and structural elucidation of three new neolignans, piperulins [corrected] A, B, and C, as platelet activating factor receptor antagonists from Piper puberulum.
Three new neolignans, piperulins [corrected] A [1], B [2], and C [3], were isolated from Piper puberulum. Their structures and relative stereochemistries were determined from spectral data and the X-ray crystallographic analysis of 1. Compounds 1 and 3 inhibit specific platelet activating factor receptor binding with IC50 values of 7.3 and 5.7 microM, respectively.
Zhang
S X
SX
Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.
Chen
K
K
Liu
X J
XJ
Zhang
D C
DC
Tao-Wiedmann
T W
TW
Leu
S L
SL
McPhail
A T
AT
Lee
K H
KH
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D001643:Bridged Bicyclo Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D018360:Crystallography, X-Ray; D066298:In Vitro Techniques; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D010980:Platelet Membrane Glycoproteins / Q000037:antagonists & inhibitors*; D011817:Rabbits; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D013056:Spectrophotometry, Ultraviolet
D001643:Bridged Bicyclo Compounds; D017705:Lignans; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C094785:piperulin A; C094786:piperulin B; C094787:piperulin C; C039351:platelet activating factor receptor