title: [Proxodolol, a new domestic preparation for lowering intraocular pressure in glaucoma].
abstract: Effects of a Russian b-a-adrenoblocker proxodolol on the intraocular pressure, ocular hemodynamics, pupil diameter, ocular functions, arterial pressure, and heart rate were studied in 105 patients (163 eyes) with primary open-angle glaucoma. A manifest hypotensive effect of proxodolol was due to depression of aqueous humor production and improvement of its outflow. Comparative study of the efficacies of proxodolol and timolol maleate by the blind test and randomization demonstrated the identity of these drugs. A synergic effect on intraocular pressure was observed when proxodolol was combined with pilocarpine and/or klofelin.
authors.forename: V N
authors.initials: VN
authors.lastname: Ermakova
authors.forename: S D
authors.initials: SD
authors.lastname: Iuzhakov
authors.forename: M D
authors.initials: MD
authors.lastname: Mashkovskiĭ
authors.forename: E M
authors.initials: EM
authors.lastname: Kolomoĭtseva
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000319:Adrenergic beta-Antagonists / Q000494:pharmacology / Q000627:therapeutic use*; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D003000:Clonidine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D004357:Drug Synergism; D004359:Drug Therapy, Combination; D005260:Female; D005902:Glaucoma, Open-Angle / Q000188:drug therapy*; D006801:Humans; D007429:Intraocular Pressure / Q000187:drug effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D010069:Oxadiazoles / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D010862:Pilocarpine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use; D013999:Timolol / Q000494:pharmacology / Q000627:therapeutic use; D014665:Vasodilator Agents / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D000317:Adrenergic alpha-Antagonists; D000319:Adrenergic beta-Antagonists; D009883:Ophthalmic Solutions; D010069:Oxadiazoles; D014665:Vasodilator Agents; D010862:Pilocarpine; C088649:proxodolol; D013999:Timolol; D003000:Clonidine
vernacular_title: Proksodolol--novyĭ otechestvennyĭ preparat dlia snizheniia vnutriglaznogo davleniia pri glaukome.