Localization of a gene for partial epilepsy to chromosome 10q.
There is strong evidence for a genetic contribution to epilepsy, but it is commonly assumed that this genetic contribution is limited to 'generalized' epilepsies, and that most forms of 'partial' epilepsy are nongenetic. In a linkage analysis of a single family containing 11 affected individuals, we obtained strong evidence for localization of a gene for partial epilepsy. This susceptibility gene maps to chromosome 10q, with a maximum two-point lod score for D10S192 of 3.99 at theta = 0.0. All affected individuals share a single haplotype for seven tightly linked contiguous markers; the maximum lod score for this haplotype is 4.83 at theta = 0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval.
Ottman
R
R
G. H. Sergievsky Center, School of Public Health, Columbia University, New York, New York 10032, USA.
Risch
N
N
Hauser
W A
WA
Pedley
T A
TA
Lee
J H
JH
Barker-Cummings
C
C
Lustenberger
A
A
Nagle
K J
KJ
Lee
K S
KS
Scheuer
M L
ML
D000293:Adolescent; D000328:Adult; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D004828:Epilepsies, Partial / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree
D005819:Genetic Markers