[The GABA-ergic system parameters of the adrenal cortex in animals with normal and stimulated steroidogenesis].
Activity of glutamate decarboxylase, a GABA synthesis enzyme, and intensity of its reception in the adrenal cortex and hypothalamus of guinea pigs and rats with normal and stimulated steroidogenesis was investigated. It has been shown that in the adrenal cortex there is a metabolic system which provides GABA synthesis from glutamate and mechanisms of GABA reception by plasmatic membranes. Mediator synthesis in the adrenal cortex is subjected to seasonal changes, GABA synthesis and reception selectively vary with administration of ACTH, prolactin and maintenance of animals on a diet with an excess of potassium ions.
Myshunina
T M
TM
Kononenko
V Ia
VIa
Mikosha
O S
OS
Tron'ko
M D
MD
D000302:Adrenal Cortex / Q000187:drug effects / Q000201:enzymology*; D000324:Adrenocorticotropic Hormone / Q000494:pharmacology; D000818:Animals; D002250:Carbon Radioisotopes; D002462:Cell Membrane / Q000187:drug effects / Q000201:enzymology; D003366:Cosyntropin / Q000494:pharmacology; D005968:Glutamate Decarboxylase / Q000187:drug effects / Q000378:metabolism; D006168:Guinea Pigs; D007031:Hypothalamus / Q000187:drug effects / Q000201:enzymology; D008297:Male; D011188:Potassium / Q000494:pharmacology; D011388:Prolactin / Q000494:pharmacology; D018079:Receptors, GABA / Q000187:drug effects / Q000378:metabolism*; D012621:Seasons; D013268:Stimulation, Chemical; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000096:biosynthesis* / Q000187:drug effects
D002250:Carbon Radioisotopes; D018079:Receptors, GABA; D003366:Cosyntropin; C006418:adrenocorticotropin zinc; D005680:gamma-Aminobutyric Acid; D000324:Adrenocorticotropic Hormone; D011388:Prolactin; D005968:Glutamate Decarboxylase; D011188:Potassium
Deiaki parametry HAMK-erhichnoï systemy kory nadnyrkovykh zaloz tvaryn u normi ta za umov stymuliatsiï steroïdohenezu.