[Postulosis palmoplantaris caused by angiotensin-converting enzyme inhibitors].
Angiotensin-converting enzyme (ACE) is identical to kinase II, which inactivates bradykinin. Inhibition of bradykinin degradation by ACE inhibitors alters the kinin-kallikrein arachidonic acid system leading to increased concentrations of inflammatory metabolites. It has previously been demonstrated that the arachidonic acid system may play a role in the pathogenesis of psoriasis/volar pustulosis. Our patient was treated with Captopril and developed a rash identical to volar pustulosis within six weeks. Captopril was substituted with Perindopril, and the eruptions had almost disappeared five months later after a short systemic treatment with steroids. One month later the patient developed the same rash. Perindopril was withdrawn and the eruptions had disappeared two months later.
Eriksen
J G
JG
Medicinsk afdeling, Nykøbing Mors Sygehus.
Christiansen
J J
JJ
Asmussen
I
I
D000368:Aged; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000009:adverse effects*; D002216:Captopril / Q000009:adverse effects*; D005260:Female; D006801:Humans; D007211:Indoles / Q000009:adverse effects*; D016234:Kallikrein-Kinin System / Q000187:drug effects; D020913:Perindopril; D011565:Psoriasis / Q000139:chemically induced*
D000806:Angiotensin-Converting Enzyme Inhibitors; D007211:Indoles; D002216:Captopril; D020913:Perindopril
Pustulosis palmoplantaris udløst af angiotensinkonverterende enzymhaemmere.