Significance of P-53 antigen in malignant melanomas and naevi of the head and neck area.
DO-7 antibody against p-53 antigen was applied for investigation of melanomas of facial skin (25 cases), oral cavity (17 cases), eye (18 cases) and naevi (25 cases). The p-53 index value (% of p-53 positive cells) was correlated with the thickness of the tumour, the presence of metastases and survival time. The difference in p-53 index between naevi and melanomas was statistically significant (p < < 0.01). A significant correlation was found between the p-53 index value and the thickness of the tumour, the presence of metastases and follow-up for patients with skin, oral and ocular melanomas. The possible diagnostic and prognostic significance of p-53 antigen in melanomas and naevi of the head and neck area is discussed.
Korabiowska
M
M
Department of Pathology, Georg August University Göttingen, Germany.
Brinck
U
U
Hoenig
J F
JF
Bartkowski
S B
SB
Kellner
S
S
Marx
D
D
Schauer
A
A
D000906:Antibodies; D005134:Eye Neoplasms / Q000401:mortality / Q000473:pathology; D005145:Face; D006258:Head and Neck Neoplasms / Q000401:mortality / Q000473:pathology*; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008545:Melanoma / Q000401:mortality / Q000473:pathology*; D009062:Mouth Neoplasms / Q000401:mortality / Q000473:pathology*; D009362:Neoplasm Metastasis; D009506:Nevus / Q000401:mortality / Q000473:pathology*; D011237:Predictive Value of Tests; D012878:Skin Neoplasms / Q000401:mortality / Q000473:pathology*; D015996:Survival Rate; D013997:Time Factors; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
D000906:Antibodies; D016159:Tumor Suppressor Protein p53