DNA index and S phase fraction in uveal malignant melanomas.
OBJECTIVE
To predict 5 year survival in patients with uveal malignant melanomas DNA indices were studied.


METHODS
Using 45 paraffin embedded uveal malignant melanomas, the DNA index and S phase fraction of each tumour were the predictor variables recorded.


RESULTS
Using the Cox proportional hazards model, aneuploid tumours and tumours which had an S phase fraction greater than 4% were significant predictors of early death. In order to demonstrate a biological gradient between a larger DNA index and shorter survival time, linear regression and transformed linear regression models were used. However, no such gradient could be demonstrated.


CONCLUSIONS
Although this study shows promise for the use of DNA studies in the prognosis of uveal malignant melanoma, the exact role of these techniques remains to be determined.
Hodge
W G
WG
Department of Ophthalmology, McGill University, Montreal, Quebec, Canada.
Duclos
A J
AJ
Rocha
G
G
Antecka
E
E
Baines
M G
MG
Corriveau
C
C
Brownstein
S
S
Deschenes
J
J
D000328:Adult; D000368:Aged; D004273:DNA, Neoplasm / Q000032:analysis*; D005260:Female; D005434:Flow Cytometry; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008545:Melanoma / Q000235:genetics* / Q000401:mortality / Q000473:pathology; D008875:Middle Aged; D015999:Multivariate Analysis; D011003:Ploidies; D011379:Prognosis; D016196:S Phase; D015996:Survival Rate; D014604:Uveal Neoplasms / Q000235:genetics* / Q000401:mortality / Q000473:pathology
D004273:DNA, Neoplasm