Catecholaminergic neurons in the nucleus tractus solitarii which send their axons to the midbrain periaqueductal gray express Fos protein after noxious stimulation of the stomach: a triple labeling study in the rat.
In rats which were injected with horseradish peroxidase (HRP) into the midbrain periaqueductal gray (PAG) and then administered with formaldehyde into the stomach, Fos-like immunoreactivity was found in tyrosine hydroxylase-like immunoreactive neurons in the nucleus tractus solitarii (NTS) which were retrogradely labeled with HRP. The results indicate that catecholaminergic NTS neurons may mediate nociceptive visceral information to the PAG.
Chen
L W
LW
Department of Anatomy, Fourth Military Medical University, Xi'an, People's Republic of China.
Rao
Z R
ZR
Shi
J W
JW
D000818:Animals; D001369:Axons / Q000502:physiology; D002395:Catecholamines / Q000502:physiology*; D006735:Horseradish Peroxidase; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000378:metabolism* / Q000502:physiology; D010146:Pain / Q000378:metabolism; D010487:Periaqueductal Gray / Q000166:cytology / Q000502:physiology*; D010812:Physical Stimulation; D016760:Proto-Oncogene Proteins c-fos / Q000096:biosynthesis*; D051381:Rats; D017207:Rats, Sprague-Dawley; D017552:Solitary Nucleus / Q000166:cytology / Q000502:physiology*; D013270:Stomach / Q000502:physiology*; D014446:Tyrosine 3-Monooxygenase / Q000378:metabolism
D002395:Catecholamines; D016760:Proto-Oncogene Proteins c-fos; D006735:Horseradish Peroxidase; D014446:Tyrosine 3-Monooxygenase