title: Comparative assessment of saccadic eye movements, psychomotor and cognitive performance in schizophrenics, their first-degree relatives and control subjects.
abstract: This study is aimed at detecting biological markers for schizophrenia. For this purpose, a total of 70 subjects (21 schizophrenic patients, 27 first-degree relatives and 22 controls) performed a series of tests assessing various attentional, psychomotor and cognitive functions and saccadic eye movements. The schizophrenics performed significantly poorer than both high-risk and control subjects in most of the tests demanding attention, concentration and psychomotor speed (d2 concentration test, reaction times and Stroop test of perceptual interference) as well as cognition (Wechsler intelligence scales). On the other hand, these tests did not differentiate between the high-risk and control subjects. This distinction, however, could be made by two other parameters: hypometria score of saccadic eye movements and ratio of verbal to performance intelligence scores. Both parameters were significantly increased in both the schizophrenic and the high-risk group, distinguishing both from the control group. The relevance of these findings in indicating a schizophrenic disposition is discussed.
authors.affiliation: Department of Neurology, University of Ulm, RKU Hospital, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Schreiber
authors.forename: J
authors.initials: J
authors.lastname: Rothmeier
authors.forename: W
authors.initials: W
authors.lastname: Becker
authors.forename: R
authors.initials: R
authors.lastname: Jürgens
authors.forename: J
authors.initials: J
authors.lastname: Born
authors.forename: G
authors.initials: G
authors.lastname: Stolz-Born
authors.forename: K P
authors.initials: KP
authors.lastname: Westphal
authors.forename: H H
authors.initials: HH
authors.lastname: Kornhuber
mesh_terms: D000328:Adult; D001143:Arousal / Q000235:genetics; D001288:Attention; D003072:Cognition Disorders / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D004193:Discrimination Learning; D005260:Female; D006801:Humans; D007360:Intelligence / Q000235:genetics; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010641:Phenotype; D011597:Psychomotor Performance; D011930:Reaction Time / Q000235:genetics; D012307:Risk Factors; D012438:Saccades / Q000235:genetics*; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012565:Schizophrenic Psychology; D014888:Wechsler Scales