[Effect of shen mai injection and its combinations on blood gas and hemodynamics of rats exposed to chronic hypoxia].
Shen Mai Injection (SMI) consisted of Panax ginseng and Ophiopogon japonica might promote the myocardial and diaphragmatic muscle contraction. The effect of SMI and its combinations were examined on the blood gas and hemodynamics of rats exposed to chronic hypoxia. SMI reduced significantly the pulmonary vascular resistance (PVR, P < 0.001), systemic vascular resistance (SVR, P < 0.001) and increased cardiac output (CO, P < 0.001), which effect was superior to the Dobutamine. If SMI was combined with Ligustrazine etc, better effect on blood gas and hemodynamics appeared than that of combined with other drugs. These combined group also presented more selective on pulmonary circulation. The results suggested that SMI and its combined with Ligustrazine could relieve the pulmonary hypertension and diaphragmatic fatigue.
Jin
X Q
XQ
Respiratory Research Dept. of Tongji Hospital, Tongji Medical University, Wuhan.
Duan
S F
SF
Niu
R J
RJ
D000818:Animals; D001784:Blood Gas Analysis; D002302:Cardiac Output / Q000187:drug effects*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D000860:Hypoxia / Q000503:physiopathology*; D007275:Injections, Intravenous; D008297:Male; D005894:Panax; D010946:Plants, Medicinal; D011719:Pyrazines / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D014655:Vascular Resistance / Q000187:drug effects*
D004365:Drugs, Chinese Herbal; D011719:Pyrazines; C017953:tetramethylpyrazine