title: Unilateral cerebral cortical and basal ganglia enhancement following overdosage of nonionic contrast media.
abstract: A 69-year-old woman developed seizures after cerebral angiography immediately preceded by coronary angiography. The preceding coronary angiography resulted in hyperconcentration, hyperosmolar loading, and overdosing of the nonionic contrast medium. A CT examination demonstrated gyriform enhancement throughout the left cortex and the left basal ganglia. Preloading with contrast material, as in this case, predisposes to disruption of the blood-brain barrier during selective common carotid or vertebral artery injection with nonionic contrast.
authors.affiliation: Department of Radiology, Southern Illinois University School of Medicine, Springfield 62769, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Kuhn
authors.forename: T J
authors.initials: TJ
authors.lastname: Burk
authors.forename: F C
authors.initials: FC
authors.lastname: Powell
mesh_terms: D000368:Aged; D001479:Basal Ganglia / Q000000981:diagnostic imaging* / Q000187:drug effects; D001812:Blood-Brain Barrier / Q000187:drug effects; D002533:Cerebral Angiography / Q000009:adverse effects; D002540:Cerebral Cortex / Q000000981:diagnostic imaging* / Q000187:drug effects; D017023:Coronary Angiography / Q000009:adverse effects; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007479:Iopamidol / Q000009:adverse effects*; D009994:Osmolar Concentration; D011856:Radiographic Image Enhancement; D012640:Seizures / Q000139:chemically induced; D014057:Tomography, X-Ray Computed
chemical_list: D007479:Iopamidol