title: Primary antiphospholipid syndrome associated with postoperative primary adrenal failure.
abstract: A 51-year-old Caucasian male without previous history of thromboembolic disease developed Coomb's positive haemolytic anaemia, thrombocytopenia, transient paranoid psychosis and bilateral adrenal haemorrhage with primary adrenal failure after surgery for inguinal hernia. The activated partial thromboplastin time was spontaneously prolonged, and lupus anticoagulant and anticardiolipin antibodies were detected. In the absence of criteria for classification of systemic lupus erythematosus (SLE), the entity was classified as a primary antiphospholipid syndrome. Despite the persistence of the serological abnormalities, the patient remains well after substitution with cortisone. Primary adrenal failure due to adrenal haemorrhage can be associated with the primary antiphospholipid syndrome.
authors.affiliation: Department of Endocrinology, Lund University Clinics, General Hospital, Malmö, Sweden.
authors.forename: K I
authors.initials: KI
authors.lastname: Papadopoulos
authors.forename: A
authors.initials: A
authors.lastname: Jönsson
authors.forename: E
authors.initials: E
authors.lastname: Berntorp
authors.forename: C
authors.initials: C
authors.lastname: Törnquist
authors.forename: U L
authors.initials: UL
authors.lastname: Hulthén
mesh_terms: D000307:Adrenal Gland Diseases / Q000150:complications / Q000175:diagnosis*; D000309:Adrenal Insufficiency / Q000209:etiology*; D016736:Antiphospholipid Syndrome / Q000209:etiology*; D016063:Blood Loss, Surgical; D003937:Diagnosis, Differential; D006470:Hemorrhage / Q000150:complications / Q000175:diagnosis*; D006552:Hernia, Inguinal / Q000601:surgery; D006801:Humans; D008297:Male; D008875:Middle Aged