title: Alopecia associated with fluconazole therapy.
abstract: OBJECTIVE
  To describe the association between fluconazole and reversible alopecia.
  
  
  METHODS
  A retrospective survey of 1) patients enrolled in NIAID Mycoses Study Group (MSG) protocols involving the long-term use of fluconazole for treatment of endemic mycoses and 2) patients treated with fluconazole outside of a protocol setting but by the MSG investigators who were MSG members.
  
  
  METHODS
  26 MSG sites in the United States.
  
  
  METHODS
  33 patients with various deep and superficial mycoses who developed alopecia while receiving fluconazole.
  
  
  RESULTS
  11 of 26 investigators reported a total of 33 patients with substantial alopecia related to fluconazole therapy. Underlying mycoses included blastomycosis, sporotrichosis, histoplasmosis, cryptococcosis, coccidioidomycosis, and mucosal candidiasis. In separate MSG studies, 17 of 136 (12.5%) and 8 of 40 (20%) patients had substantial reversible alopecia associated with fluconazole therapy. Eight patients who were not in the protocol had similar adverse effects. Twenty-nine of 33 patients (88%) received at least 400 mg of fluconazole daily for a mean of 7.1 months. Alopecia developed a median of 3 months after initiation of fluconazole therapy and involved the scalp in all patients. Other sites were involved in about one third of patients. Three patients required wigs because of extensive hair loss. Alopecia resolved within 6 months of discontinuation of fluconazole therapy or reduction of the daily dose by at least 50%.
  
  
  CONCLUSIONS
  Alopecia appears to be a common adverse event associated with higher-dose (400 mg/d) fluconazole given for 2 months or longer. This effect may be severe but is reversed by discontinuing fluconazole therapy or substantially reducing the daily dose.
authors.affiliation: University of Alabama, Birmingham, USA.
authors.forename: P G
authors.initials: PG
authors.lastname: Pappas
authors.forename: C A
authors.initials: CA
authors.lastname: Kauffman
authors.forename: J
authors.initials: J
authors.lastname: Perfect
authors.forename: P C
authors.initials: PC
authors.lastname: Johnson
authors.forename: D S
authors.initials: DS
authors.lastname: McKinsey
authors.forename: D M
authors.initials: DM
authors.lastname: Bamberger
authors.forename: R
authors.initials: R
authors.lastname: Hamill
authors.forename: P K
authors.initials: PK
authors.lastname: Sharkey
authors.forename: S W
authors.initials: SW
authors.lastname: Chapman
authors.forename: J D
authors.initials: JD
authors.lastname: Sobel
mesh_terms: D000328:Adult; D000368:Aged; D000505:Alopecia / Q000139:chemically induced*; D004334:Drug Administration Schedule; D005260:Female; D015725:Fluconazole / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009181:Mycoses / Q000188:drug therapy; D012189:Retrospective Studies
chemical_list: D015725:Fluconazole