title: Sequential levels of ceftriaxone in intervertebral disc removed as part of scoliosis surgery.
abstract: A single intravenous loading dose of 1 g ceftriaxone was injected at different intervals before surgery for correction of spinal scoliosis. Serum and concomitant disc samples were obtained and assay was performed using high-pressure liquid chromatography. Data showed that the antibiotic levels in intervertebral disc space reached 3.5 mcg/mg, which is above the minimum inhibitory concentration for most of the relevant pathogens, as early as 1 hour after intravenous administration. These therapeutic levels were maintained for more than 5 hours, an accepted period for most spinal surgical procedures.
authors.affiliation: Infectious Diseases Unit, Meir Hospital, Kfar-Saba, Israel.
authors.forename: R
authors.initials: R
authors.lastname: Lang
authors.forename: Y
authors.initials: Y
authors.lastname: Folman
authors.forename: M
authors.initials: M
authors.lastname: Ravid
authors.forename: T
authors.initials: T
authors.lastname: Bental
authors.forename: R
authors.initials: R
authors.lastname: Gepstein
mesh_terms: D000328:Adult; D002443:Ceftriaxone / Q000008:administration & dosage / Q000378:metabolism*; D002648:Child; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007403:Intervertebral Disc / Q000378:metabolism* / Q000601:surgery; D008297:Male; D011292:Premedication; D012600:Scoliosis / Q000601:surgery; D013997:Time Factors
chemical_list: D002443:Ceftriaxone