Regulation of globin gene expression in erythroid cells.
Study of globin gene regulation has served as a useful paradigm for cell-specific and developmental control of transcription in higher eukaryotic cells. Recent work directed toward the identification and characterization of the cis-regulatory elements and transcription factors important for both aspects of control is reviewed. Particular emphasis is placed on the organization and function of globin locus control regions, mechanisms of switching of globin gene expression during development, and functions of the major erythroid-specific nuclear regulatory proteins.
Orkin
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Division of Hematology-Oncology, Children's Hospital, Boston, MA 02115, USA.
D001483:Base Sequence; D002843:Chromatin / Q000737:chemistry / Q000235:genetics; D004912:Erythrocytes / Q000378:metabolism*; D015672:Erythroid Precursor Cells / Q000378:metabolism; D018507:Gene Expression Regulation, Developmental / Q000235:genetics*; D005914:Globins / Q000235:genetics*; D008957:Models, Genetic; D008969:Molecular Sequence Data; D005810:Multigene Family / Q000235:genetics; D011401:Promoter Regions, Genetic / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics
D002843:Chromatin; D014157:Transcription Factors; D005914:Globins