Trimetazidine and myocardial ischemic contracture in isolated rat heart.
Trimetazidine, a drug thought to improve ischemia by a metabolic mechanism, was able to inhibit the formation of ischemic contracture in isolated hearts taken from rats pretreated with the drug. The mechanism of this potentially important action is unknown.
Opie
L H
LH
Heart Research Unit, University of Cape Town, Medical School, South Africa.
Boucher
F
F
D000818:Animals; D066298:In Vitro Techniques; D009200:Myocardial Contraction / Q000187:drug effects*; D017202:Myocardial Ischemia / Q000378:metabolism / Q000503:physiopathology* / Q000517:prevention & control*; D051381:Rats; D014292:Trimetazidine / Q000494:pharmacology*
D014292:Trimetazidine