title: Antibody to annexin V has anti-phospholipid and lupus anticoagulant properties.
abstract: Anti-annexin V (anti-ANXV) IgG and lupus anticoagulant (LAC) were both shown to be capable of inducing apoptosis in umbilical vein endothelial cells [Nakamura et al.: Biochem Biophys Res Commun 205:1488-1493, 1994]. In the present study, we have demonstrated that anti-ANXV IgG prolongs the activated partial thromboplastin time and has an affinity for phospholipids in enzyme-linked immunosorbent assay. This indicates overlapping of anti-ANXV and LAC activities, suggesting that ANXV may be involved in the autoimmune mechanism for LAC production.
authors.affiliation: Department of Molecular Medicine, Osaka Medical Center, Japan.
authors.forename: N
authors.initials: N
authors.lastname: Nakamura
authors.forename: C
authors.initials: C
authors.lastname: Kuragaki
authors.forename: Y
authors.initials: Y
authors.lastname: Shidara
authors.forename: K
authors.initials: K
authors.lastname: Yamaji
authors.forename: Y
authors.initials: Y
authors.lastname: Wada
mesh_terms: D000818:Animals; D017304:Annexin A5 / Q000276:immunology*; D000906:Antibodies / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D017152:Antibodies, Antiphospholipid / Q000276:immunology / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000276:immunology / Q000378:metabolism*; D011817:Rabbits
chemical_list: D017304:Annexin A5; D000906:Antibodies; D017152:Antibodies, Antiphospholipid; D016682:Lupus Coagulation Inhibitor