Apophysomyces elegans infection in a renal transplant recipient.
A 50-year-old cadaveric renal transplant recipient on immunosuppressive therapy is described with post-traumatic cutaneous infection caused by Apophysomyces elegans. He showed no evidence of hematogenous dissemination and recovered fully after therapy with extensive local debridement and amphotericin B lipid complex. An apparent drug-drug interaction between amphotericin B lipid complex and cyclosporine was encountered. The course of A elegans infection in transplant recipients may be similar to that described in immunocompetent hosts. A elegans infection should be considered in evaluation of post-traumatic cutaneous infection not readily responsive to antibacterial therapy.
Naguib
M T
MT
Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center, Oklahoma City, USA.
Huycke
M M
MM
Pederson
J A
JA
Pennington
L R
LR
Burton
M E
ME
Greenfield
R A
RA
D003881:Dermatomycoses / Q000628:therapy; D006801:Humans; D007166:Immunosuppressive Agents / Q000008:administration & dosage; D016030:Kidney Transplantation / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009091:Mucormycosis / Q000276:immunology / Q000628:therapy; D009894:Opportunistic Infections / Q000628:therapy; D014946:Wound Infection / Q000382:microbiology
D007166:Immunosuppressive Agents