Genotoxic monitoring of workers at a hazardous waste disposal site in Mexico.
Chromosomal aberration and sister chromatid exchange (SCE) frequencies were determined in lymphocytes cultured from 12 high-risk individuals working at a landfill for hazardous waste disposal. Cell proliferation kinetics (CPK) was also determined. Compared with 7 control individuals, no effects were observed with respect to SCE nor on CPK. However, the workers exhibited significantly higher frequencies of chromatid and chromosomal deletions, the magnitude of which was related with exposure time. This study suggests that when high-risk exposure is suspected, determining biomarkers of genotoxic damage (e.g., chromosomal aberrations), is useful for risk assessments.
Gonsebatt
M E
ME
Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Ciudad Universitaria.
Salazar
A M
AM
Montero
R
R
Díaz Barriga
F
F
Yáñez
L
L
Gómez
H
H
Ostrosky-Wegman
P
P
D002455:Cell Division / Q000235:genetics; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004784:Environmental Monitoring; D005069:Evaluation Studies as Topic; D006256:Hazardous Waste; D006801:Humans; D016014:Linear Models; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D008800:Mexico; D016273:Occupational Exposure; D012037:Refuse Disposal; D018570:Risk Assessment; D012854:Sister Chromatid Exchange
D006256:Hazardous Waste