Familial occurrence of patent ductus arteriosus.
We describe 7 relatives with patent ductus arteriosus (PDA) and a slightly unusual facial appearance with prominent midface with nose elongation and flattening of the nasal bridge, wide-set eyes, downturned palpebral fissures, mild ptosis, thickened lips, and apparently slightly low-set ears. Autosomal dominant inheritance is suggested in this family. Other families where affected members have PDA and a similar facial appearance and autosomal dominant inheritance were described previously by Char [1978: BD:OAS XIV (6B):303-305] and Temple [1992: Clin Dysmorphol 1:17-21].
Sletten
L J
LJ
Ray and Hattie Anderson Center for the Study of Hereditary Cardiac Disease, Department of Pediatrics, University of Minnesota, Minneapolis, USA.
Pierpont
M E
ME
D002648:Child; D004374:Ductus Arteriosus, Patent / Q000235:genetics*; D005145:Face; D005260:Female; D005799:Genes, Dominant; D006801:Humans; D008297:Male; D010375:Pedigree