title: The isolation and structural elucidation of three new neolignans, piperulins [corrected] A, B, and C, as platelet activating factor receptor antagonists from Piper puberulum.
abstract: Three new neolignans, piperulins [corrected] A [1], B [2], and C [3], were isolated from Piper puberulum. Their structures and relative stereochemistries were determined from spectral data and the X-ray crystallographic analysis of 1. Compounds 1 and 3 inhibit specific platelet activating factor receptor binding with IC50 values of 7.3 and 5.7 microM, respectively.
authors.affiliation: Natural Products Laboratory, School of Pharmacy, University of North Carolina, Chapel Hill 27599, USA.
authors.forename: S X
authors.initials: SX
authors.lastname: Zhang
authors.forename: K
authors.initials: K
authors.lastname: Chen
authors.forename: X J
authors.initials: XJ
authors.lastname: Liu
authors.forename: D C
authors.initials: DC
authors.lastname: Zhang
authors.forename: T W
authors.initials: TW
authors.lastname: Tao-Wiedmann
authors.forename: S L
authors.initials: SL
authors.lastname: Leu
authors.forename: A T
authors.initials: AT
authors.lastname: McPhail
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D001643:Bridged Bicyclo Compounds / Q000302:isolation & purification* / Q000494:pharmacology; D002681:China; D018360:Crystallography, X-Ray; D066298:In Vitro Techniques; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D010980:Platelet Membrane Glycoproteins / Q000037:antagonists & inhibitors*; D011817:Rabbits; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; D013056:Spectrophotometry, Ultraviolet
chemical_list: D001643:Bridged Bicyclo Compounds; D017705:Lignans; D010980:Platelet Membrane Glycoproteins; D011956:Receptors, Cell Surface; D043562:Receptors, G-Protein-Coupled; C094785:piperulin A; C094786:piperulin B; C094787:piperulin C; C039351:platelet activating factor receptor