title: Rediversion after ileal pouch-anal anastomosis. Causes of failures and predictors of subsequent pouch salvage.
abstract: OBJECTIVE
  The aim of this study was to understand better the cause and predictability of pouch failure requiring rediversion after ileal pouch-anal anastomosis and to assess the ultimate outcome of patients in a large ileal pouch series who required rediversion.
  
  
  METHODS
  Data from 460 patients completing ileal pouch-anal anastomosis at one institution were recorded from both a prospectively accumulated ileal pouch registry and patient medical records.
  
  
  RESULTS
  Of 460 patients, 21 (4.6 percent) who underwent ileal pouch-anal anastomosis required rediversion. Five of these patients subsequently had successful restoration of pouch continuity, leaving a permanent failure rate of 16 of 460 patients (3.5 percent). The most common reasons for rediversion were pouch fistula formation (12) and poor functional results (5). Preoperative factors, including age, previous colectomy, and indication for colectomy, did not predict eventual need for rediversion. Patients requiring rediversion had significantly higher rates of postoperative complications (95 vs. 43 percent; P < 0.001). Specifically, this group had a higher rate of postoperative pouch fistula (57 vs. 3.4 percent; P < 0.001). Additionally, a final diagnosis of Crohn's disease significantly predicted the need for rediversion. Permanent pouch failure occurred in 36.8 percent of patients with a final diagnosis of Crohn's disease compared with 1.4 percent of patients with a final diagnosis of ulcerative colitis (P < 0.001). All five salvaged patients had fistula formation in the absence of Crohn's disease.
  
  
  CONCLUSIONS
  The overall rate of permanent pouch failure is low. The majority of failures were related to fistula formation associated with Crohn's disease or poor functional results. Pouches complicated by fistulas not associated with Crohn's disease can be salvaged with temporary rediversion.
authors.affiliation: Department of Colon and Rectal Surgery, Lahey Hitchcock Clinic, Burlington, Massachusetts 01805, USA.
authors.forename: E F
authors.initials: EF
authors.lastname: Foley
authors.forename: D J
authors.initials: DJ
authors.lastname: Schoetz
authors.forename: P L
authors.initials: PL
authors.lastname: Roberts
authors.forename: P W
authors.initials: PW
authors.lastname: Marcello
authors.forename: J J
authors.initials: JJ
authors.lastname: Murray
authors.forename: J A
authors.initials: JA
authors.lastname: Coller
authors.forename: M C
authors.initials: MC
authors.lastname: Veidenheimer
mesh_terms: D011125:Adenomatous Polyposis Coli / Q000601:surgery; D000293:Adolescent; D000328:Adult; D000367:Age Factors; D003082:Colectomy; D003093:Colitis, Ulcerative / Q000175:diagnosis / Q000601:surgery; D003424:Crohn Disease / Q000175:diagnosis / Q000601:surgery; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D007081:Ileostomy / Q000534:rehabilitation; D007412:Intestinal Fistula / Q000209:etiology / Q000601:surgery; D008297:Male; D008875:Middle Aged; D016737:Proctocolectomy, Restorative / Q000009:adverse effects* / Q000534:rehabilitation; D011446:Prospective Studies; D012042:Registries; D012086:Reoperation; D012189:Retrospective Studies; D017211:Treatment Failure; D016896:Treatment Outcome