title: Long-term suppressive therapy for Candida parapsilosis-induced prosthetic valve endocarditis.
abstract: Prompt valve replacement is advocated in patients in whom candidal prosthetic valve endocarditis develops. Unfortunately, some patients with this condition are considered nonsurgical candidates, and they are unable to tolerate long-term administration of amphotericin B with or without flucytosine. Herein we describe a patient with Candida parapsilosis-induced prosthetic valve endocarditis in whom oral administration of fluconazole during an 11-month period successfully suppressed the fungal infection. Three previously published cases indicate that long-term noncurative suppressive therapy for C. parapsilosis-induced prosthetic valve endocarditis may allow prolonged symptom-free survival for such patients.
authors.affiliation: Section of Infectious Diseases, University of Tennessee Medical Center at Knoxville 37920-6999, USA.
authors.forename: L M
authors.initials: LM
authors.lastname: Baddour
mesh_terms: D002177:Candidiasis / Q000188:drug therapy* / Q000382:microbiology; D004696:Endocarditis / Q000188:drug therapy* / Q000382:microbiology*; D006350:Heart Valve Prosthesis / Q000382:microbiology*; D006801:Humans; D008297:Male; D008875:Middle Aged; D016459:Prosthesis-Related Infections / Q000188:drug therapy* / Q000382:microbiology*