Interaction specificity of benzimidazol group compounds with AT-containing polynucleotides.
The interaction between polynucleotides: poly(dA)-poly(dT), poly(dA-dT), poly(am2dA-dT), and the AT-specific compounds of benzimidazol group has been studied. It is been shown that these compounds bind to poly(dA)-poly(dT) and poly(dA-dT) at low and high salt concentration in solution. Poly(am2dA-dT) interacts with AT-specific compounds only at low salt, where this polynucleotide is in a B-form, but not at high salt, when the polynucleotide converts to another conformation. Thus, the interaction specificity of the groove-binding ligands is influenced not only by the minor groove substituents, but the peculiarities of the secondary structure of polynucleotides.
Akimenko
N M
NM
Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow.
Garabadgiu
A V
AV
Skuratovskii IYa
Sagi
J
J
Szabolcs
A
A
Ebinger
K
K
D001562:Benzimidazoles / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D002942:Circular Dichroism; D006860:Hydrogen Bonding; D009994:Osmolar Concentration; D011067:Poly dA-dT / Q000737:chemistry* / Q000378:metabolism; D012965:Sodium Chloride
D001562:Benzimidazoles; D011067:Poly dA-dT; D012965:Sodium Chloride