A novel partial t haplotype with a brachyury-independent effect on tail phenotype.
The btm (brachyury-interacting tail length modifier) mutation was discovered in strain MOL-NIS derived from Japanese wild mice (Mus musculus molossinus) as an autosomal recessive mutation. Homozygotes for this mutation show a short tail phenotype and, moreover, this mutation causes the tailless character by interacting with the T (brachyury) gene on Chromosome (Chr) 17. Our linkage tests and RFLP analyses suggest that btm is located within the t complex on Chr 17 and represents a new partial t haplotype.
Fujimoto
A
A
Laboratory of Animal Genetics, School of Agricultural Sciences, Nagoya University, Japan.
Wakasugi
N
N
Tomita
T
T
D000818:Animals; D002874:Chromosome Mapping; D006239:Haplotypes; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D008809:Mice, Inbred C3H; D008810:Mice, Inbred C57BL; D008869:Microtubule-Associated Proteins; D009154:Mutation; D009687:Nuclear Proteins / Q000235:genetics; D010641:Phenotype; D012150:Polymorphism, Restriction Fragment Length; D013623:Tail; D044767:Ubiquitin-Protein Ligases; D056427:t-Complex Genome Region
D047908:Intracellular Signaling Peptides and Proteins; D008869:Microtubule-Associated Proteins; D009687:Nuclear Proteins; C116196:PPP1R11 protein, human; D044767:Ubiquitin-Protein Ligases