Collectins and viral infection.
Members of the collectin protein family are beta-inhibitors of influenza virus infectivity. They bind to carbohydrate on the surface of influenza virus and sterically inhibit virus interaction with host cells, and may also act as opsonins. We propose that collectins, by interacting with glycosylated viruses, act as innate inhibitors of viral infection.
Malhotra
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Dept of Biochemistry, Oxford University, UK.
Sim
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RB
D000818:Animals; D000998:Antiviral Agents / Q000378:metabolism*; D037222:Collectins; D006031:Glycosylation; D006801:Humans; D037102:Lectins / Q000378:metabolism*; D009975:Orthomyxoviridae / Q000378:metabolism*; D009976:Orthomyxoviridae Infections / Q000821:virology; D012712:Serum Globulins / Q000378:metabolism*
D000998:Antiviral Agents; D037222:Collectins; D037102:Lectins; D012712:Serum Globulins; C086954:collectin-43 protein, bovine