Immunoblastic lymphadenopathy-like T-cell lymphoma displaying rearrangement of both IgH and TCR beta genes after 4-year follow-up of idiopathic eosinophilia.
Immunoblastic lymphadenopathy (IBL)-like T-cell lymphoma (IBL-T) occurred in a 60-year-old female after a 4-year follow-up of idiopathic eosinophilia and upper pharyngeal inflammatory tumor with infiltration of mature eosinophils. Gene analysis of tumor cells revealed rearrangement of both IgH and TCR beta genes. The patient died of lymphoma seven months after the onset of the illness, in spite of chemotherapy against lymphoma. The relationship between eosinophilia and the pathogenesis of IBL-T, as well as the significance of the rearrangement of both IgH and TCR beta genes are discussed.
Takeda
M
M
Department of Internal Medicine, Japanese Red Cross Asahikawa Hospital.
Kohda
K
K
Fujisaki
Y
Y
Tsuji
A
A
Takayanagi
N
N
Nakazawa
O
O
Andoh
M
M
Yanai
O
O
D004802:Eosinophilia / Q000150:complications*; D017809:Fatal Outcome; D005260:Female; D005500:Follow-Up Studies; D015329:Gene Rearrangement, T-Lymphocyte / Q000235:genetics*; D005803:Genes, Immunoglobulin; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics*; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000150:complications / Q000235:genetics*; D008875:Middle Aged; D016609:Neoplasms, Second Primary / Q000097:blood / Q000235:genetics; D010610:Pharyngeal Neoplasms / Q000150:complications; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000235:genetics*
D007143:Immunoglobulin Heavy Chains; D016693:Receptors, Antigen, T-Cell, alpha-beta