[Effect of glucocorticoid receptor blockade on pulmonary and renal vascular permeability in scalded rats].
With glucocorticoid receptor (GR) blockade by RU38486, a competitive antagonist of GR, the change in contents of FITC labeled albumin (FITC-albumin) in pulmonary and renal tissue in scalded rats have been measured to study the changes in vascular permeability. The result showed that the contents of FITC-albumin in pulmonary and renal tissue in the scalded rats were markedly higher than those of the controls (lung: P < 0.05, kidney: P < 0.001). When the scalded rats were given GR blockade, the contents of FITC-albumin in pulmonary and renal tissue were significantly higher than those of rats with scald only (P < 0.05). The results indicated: (1) the pulmonary and renal vascular permeability in scalded rats was markedly enhanced; (2) GR blockade might aggravate the increase in vascular permeability caused by scald, so that the protective effect of glucocorticoid (GC) on vascular permeability seemed to be reversed.
Lin
H
H
Department of Pathophysiology, Second Military Medical University, Shanghai.
Gong
X
X
Zhong
J
J
D000818:Animals; D002056:Burns / Q000503:physiopathology*; D002199:Capillary Permeability / Q000187:drug effects*; D007668:Kidney / Q000098:blood supply; D008168:Lung / Q000098:blood supply; D008297:Male; D015735:Mifepristone / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011965:Receptors, Glucocorticoid / Q000187:drug effects*
D011965:Receptors, Glucocorticoid; D015735:Mifepristone