title: Can quantitative 99mTc-MDP bone scans be used to predict longitudinal growth of epiphyseal plate allografts after microvascular transplantation? An experimental study.
abstract: Allograft and autograft microvascular proximal tibial epiphyseal plate transplants were performed in female New Zealand White (NZW) rabbits to quantify the growth rate and total growth potential of immunosuppressed and nonimmunosuppressed rabbits. The purpose of this experiment is to examine whether the 99mTc-MDP radionuclide uptake of the transplanted epiphyseal plate at 1 week postoperatively, done to assess anastomotic patency of the transplant, could also serve as a predictor of eventual longitudinal growth of the transplant or replant. All transplants and replants demonstrating positive 99mTc-MDP uptake in the proximal tibial epiphyseal plate at 1 week showed continued longitudinal growth. The precise amount of 99mTc-MDP uptake, however, did not correlate with the amount of growth at 3 and 5 weeks follow-up.
authors.affiliation: Division of Surgical Research, Hospital for Sick Children, Toronto, Ontario, Canada.
authors.forename: M I
authors.initials: MI
authors.lastname: Boyer
authors.forename: D
authors.initials: D
authors.lastname: Gilday
authors.forename: A
authors.initials: A
authors.lastname: Kiral
authors.forename: L
authors.initials: L
authors.lastname: Nolan
authors.forename: C V
authors.initials: CV
authors.lastname: Bowen
mesh_terms: D000818:Animals; D001808:Blood Vessels / Q000637:transplantation; D001842:Bone and Bones / Q000000981:diagnostic imaging*; D005260:Female; D006132:Growth Plate / Q000098:blood supply / Q000254:growth & development* / Q000637:transplantation*; D011237:Predictive Value of Tests; D011817:Rabbits; D011877:Radionuclide Imaging; D012044:Regression Analysis; D013669:Technetium Tc 99m Medronate; D013977:Tibia; D014182:Transplantation, Autologous; D014184:Transplantation, Homologous
chemical_list: D013669:Technetium Tc 99m Medronate