A new polyether acid from a cold water marine sponge, a Phakellia species.
A new polyether acid, 14, 15-dihydrodinophysistoxin-1 [1], was isolated along with dinophysistoxin-1 [2] and okadaic acid [3], from an unidentified species of the sponge genus Phakellia. The structure of 1 was assigned by comparison of its 1H- and 13C-nmr and fabms spectral data to those of 2 and 3, as well as interpretation of homonuclear 2D nmr data. Compounds 1-3 showed cytotoxicity against L-1210 leukemia cells with IC50 values of 3 ng/ml. The isolation, structure determination, and biological activities of these compounds are described (1).
Sakai
R
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Rogers Adams Laboratory, Department of Chemistry, University of Illinois, Urbana 61801, USA.
Rinehart
K L
KL
D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D002852:Chromatography, Ion Exchange; D006224:Cricetinae; D000882:Haplorhini; D018259:Herpesvirus 1, Human / Q000187:drug effects; D009682:Magnetic Resonance Spectroscopy; D011161:Porifera / Q000737:chemistry*; D011714:Pyrans / Q000737:chemistry / Q000302:isolation & purification*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured; D014721:Vesicular stomatitis Indiana virus / Q000187:drug effects
C094713:14,15-dihydrodinophysistoxin 1; D000970:Antineoplastic Agents; D000998:Antiviral Agents; D011714:Pyrans