Heart transplantation in an 8-month-old girl. 10th anniversary report.
In 1984, Dr. Denton A. Cooley led a surgical team that implanted a cardiac allograft in an 8-month-old girl who had end-stage cardiac disease secondary to endocardial fibroelastosis. At that time, experience with cardiac transplantation in infants was limited, and the long-term effects of the procedure were cause for concern. Ten years later, our patient is a healthy 4th-grade student who enjoys a remarkably normal life. She has grown and developed quite satisfactorily, and her heart has enlarged in proportion to her overall somatic growth. Long-term immunosuppression has produced no adverse effects, and the child's medical problems have differed little from those of her peers. This landmark case has yielded preliminary answers to a number of important questions about cardiac transplantation in infants and has confirmed our original opinion that the procedure is well warranted in selected patients.
Frazier
O H
OH
Division of Cardiovascular Surgery, Texas Heart Institute, Houston 77225-0345, USA.
Okereke
O U
OU
Radovancĕvić
B
B
Towbin
J A
JA
Price
J K
JK
Denfield
S
S
Chandler
L B
LB
Powers
P
P
Bricker
J T
JT
D002648:Child; D002657:Child Development / Q000502:physiology; D002675:Child, Preschool; D004695:Endocardial Fibroelastosis / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006321:Heart / Q000254:growth & development / Q000503:physiopathology; D016027:Heart Transplantation / Q000502:physiology*; D006439:Hemodynamics / Q000502:physiology; D006801:Humans; D007166:Immunosuppressive Agents / Q000627:therapeutic use; D007223:Infant; D011183:Postoperative Complications / Q000209:etiology / Q000628:therapy
D007166:Immunosuppressive Agents