title: [Portal and peripheral blood immunoreactive insulin concentrations after glucose infusion during gastrectomy].
abstract: We evaluated portal and peripheral blood immunoreactive insulin concentrations (IRI) after glucose infusion in patients undergoing gastrectomy. Seventy-four patients were divided into following two groups: 68 received 25g glucose infusion in an hour (glucose group), and the remainder received no glucose (control group). Portal blood IRI level in glucose group was about thirty-fold higher than that in control group. However, peripheral blood IRI did not correlate with portal blood IRI in glucose group. In addition, significant negative correlation between portal blood IRI and blood glucose was observed in glucose group. Our results reveal that adequate pancreatic insulin secretion occurs after glucose infusion during gastrectomy, but peripheral blood IRI does not reflect this pancreatic insulin secretion. The results also suggest that blood glucose may be regulated by the liver under these conditions.
authors.affiliation: Department of Anesthesia, Kanagawa Cancer Center Hospital, Yokohama.
authors.forename: J
authors.initials: J
authors.lastname: Hayakawa
authors.forename: H
authors.initials: H
authors.lastname: Motohashi
authors.forename: M
authors.initials: M
authors.lastname: Sairenji
authors.forename: O
authors.initials: O
authors.lastname: Kobayashi
authors.forename: Y
authors.initials: Y
authors.lastname: Usuda
mesh_terms: D000368:Aged; D001786:Blood Glucose / Q000378:metabolism; D005260:Female; D005743:Gastrectomy; D005947:Glucose / Q000008:administration & dosage*; D006801:Humans; D007328:Insulin / Q000097:blood* / Q000378:metabolism; D000078790:Insulin Secretion; D007432:Intraoperative Period; D008099:Liver / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D011168:Portal System
chemical_list: D001786:Blood Glucose; D007328:Insulin; D005947:Glucose