Single-dose intraperitoneal radioimmunotherapy with the murine monoclonal antibody I-131 MOv18: clinical results in patients with minimal residual disease of ovarian cancer.
Sixteen of 19 enrolled patients with minimal residual disease of ovarian cancer (macroscopic disease < 5 mm or positive blind biopsies and/or positive peritoneal washing), demonstrated by surgical second-look, underwent intraperitoneal radioimmunotherapy (RIT) with the radiolabelled monoclonal antibody I-131 MOv18 (mean dose 14 mg of MOv18 with 3700 GBq of I-131) 30-40 days after the second-look procedure. Clinical follow-up and/or third-look evaluation performed 90 days after RIT showed complete response (CR) in 5 patients, no change (NC) in 6 patients and progressive disease (PD) in 5 patients. Follow-up study showed long-term maintained CR in 1 patient (34 months) and relapses in the other 4 patients after a mean disease-free period of 10.5 months. 5 NC patients showed clinical or instrumental progression after a mean disease-free period of 13 months. The toxicity of RIT was negligible. Only 1 patient showed mild and transient bone marrow suppression (platelet count nadir 52,000 mm3 after 30 days). HAMA production was demonstrated in 94% (15/16) of patients. In conclusion, RIT appears to be a very promising therapeutic approach to treat minimal residual disease of ovarian cancer.
Crippa
F
F
Divisione di Medicina Nucleare, Istituto Nazionale Tumori, Milano, Italy.
Bolis
G
G
Seregni
E
E
Gavoni
N
N
Scarfone
G
G
Ferraris
C
C
Buraggi
G L
GL
Bombardieri
E
E
D000328:Adult; D000368:Aged; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use*; D010535:Laparoscopy; D008875:Middle Aged; D018365:Neoplasm, Residual / Q000532:radiotherapy*; D010051:Ovarian Neoplasms / Q000532:radiotherapy*; D010529:Peritoneal Cavity; D016499:Radioimmunotherapy; D012086:Reoperation
D000911:Antibodies, Monoclonal; D007457:Iodine Radioisotopes