title: [Generalized histoplasmosis due to endogenous reactivation of a latent infection in an HIV-seronegative man].
abstract: A 63-year-old, Dutch, HIV-seronegative man presented with anal pain and itch of 6 months' duration, a perianal ulcer and a solitary colon ulcer. Crohn's disease was suspected; the patient was treated with corticosteroids, but later died. Autopsy revealed disseminated histoplasmosis, a fungal disease rare in the Netherlands. The patient had visited Honduras. This case report illustrates that disseminated histoplasmosis may mimic Crohn's disease leading to a delay in the diagnosis.
authors.affiliation: Afd. Pathologie, Academisch Ziekenhuis, Nijmegen.
authors.forename: R A
authors.initials: RA
authors.lastname: Koot
authors.forename: S H
authors.initials: SH
authors.lastname: van Uum
authors.forename: A H
authors.initials: AH
authors.lastname: Naber
authors.forename: J F
authors.initials: JF
authors.lastname: Meis
mesh_terms: D003424:Crohn Disease / Q000175:diagnosis*; D003937:Diagnosis, Differential; D017809:Fatal Outcome; D006660:Histoplasmosis / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D011349:Proctitis / Q000382:microbiology*; D014456:Ulcer / Q000382:microbiology / Q000473:pathology
vernacular_title: Gegeneraliseerde histoplasmose door endogene reactivering van een latente infectie bij een HIV-seronegatieve man.