title: Quantification of inflammation in the wrist with gadolinium-enhanced MR imaging and PET with 2-[F-18]-fluoro-2-deoxy-D-glucose.
abstract: OBJECTIVE
  To quantify the activity of joint inflammation with magnetic resonance (MR) imaging and positron emission tomography (PET).
  
  
  METHODS
  Gadolinium-enhanced MR imaging and 2-[fluorine-18]fluoro-2-deoxy-D-glucose (FDG) PET of the wrist were performed prospectively in 12 patients receiving antiinflammatory therapy. Patients were studied three times: off medications for 2 weeks, after 2 weeks of treatment with prednisone or nonsteroid antiinflammatory drugs, and after 12 weeks of treatment with methotrexate. Volume of enhancing pannus (VEP) was determined from fat-suppressed MR images (12 patients). FDG uptake was calculated from PET images (11 patients).
  
  
  RESULTS
  VEP and FDG uptake were closely correlated (r > .86, P < .0001), as were changes in VEP and standardized uptake volume (r > .91, P < .0002). VEP and FDG uptake were strongly associated with clinical findings in wrists (P < .002) but not with treatment outcomes (P > .05).
  
  
  CONCLUSIONS
  Contrast material-enhanced MR imaging and PET allow quantification of volumetric and metabolic changes in joint inflammation and comparison of efficacies of antiinflammatory drugs.
authors.affiliation: Department of Radiology, Massachusetts General Hospital, Boston 02114, USA.
authors.forename: W E
authors.initials: WE
authors.lastname: Palmer
authors.forename: D I
authors.initials: DI
authors.lastname: Rosenthal
authors.forename: O I
authors.initials: OI
authors.lastname: Schoenberg
authors.forename: A J
authors.initials: AJ
authors.lastname: Fischman
authors.forename: L S
authors.initials: LS
authors.lastname: Simon
authors.forename: R H
authors.initials: RH
authors.lastname: Rubin
authors.forename: R P
authors.initials: RP
authors.lastname: Polisson
mesh_terms: D000082:Acetaminophen / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D015535:Arthritis, Psoriatic / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D001172:Arthritis, Rheumatoid / Q000175:diagnosis* / Q000000981:diagnostic imaging* / Q000188:drug therapy; D003287:Contrast Media; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D011431:Dextropropoxyphene / Q000627:therapeutic use; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005682:Gadolinium; D006801:Humans; D007089:Image Enhancement; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D010865:Pilot Projects; D011241:Prednisone / Q000627:therapeutic use; D011446:Prospective Studies; D014055:Tomography, Emission-Computed; D016896:Treatment Outcome; D014955:Wrist Joint / Q000000981:diagnostic imaging* / Q000473:pathology*
chemical_list: D003287:Contrast Media; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D000082:Acetaminophen; D003847:Deoxyglucose; D005682:Gadolinium; D011431:Dextropropoxyphene; D011241:Prednisone