Metal ion-induced permeability changes in cell membranes: a minireview.
1. The paper summarizes the effects of the metal ions Cu2+, Pb2+, Ag+, Hg2+, Zn2+, and Cd2+ applied externally or internally to the surface membrane of different excitable cells. 2. Conductance changes induced by metal ions, and metal ion-activated current, are compared with respect to their ion and voltage dependence. 3. It is suggested that metal ion-induced effects can be realized through special structures of the cell membrane, the metal ion "receptors," although other mechanisms, as, for example, competition for Ca-binding sites in the channel forming proteins, cannot be excluded.
Kiss
T
T
Balaton Limnological Research Institute, Hungarian Academy of Science, Tihany.
Osipenko
O
O
D000818:Animals; D002104:Cadmium / Q000494:pharmacology; D002463:Cell Membrane Permeability / Q000187:drug effects*; D003300:Copper / Q000494:pharmacology; D066298:In Vitro Techniques; D007854:Lead / Q000494:pharmacology; D008628:Mercury / Q000494:pharmacology; D008670:Metals / Q000494:pharmacology*; D009474:Neurons / Q000187:drug effects / Q000502:physiology*; D012834:Silver / Q000494:pharmacology; D015032:Zinc / Q000494:pharmacology
D008670:Metals; D002104:Cadmium; D007854:Lead; D012834:Silver; D003300:Copper; D008628:Mercury; D015032:Zinc