Induction of acute hypocalcemia in rats.
Decreased plasma calcium levels could produce important changes in cellular functions and drug responses. This communication describes the temporal decrease in calcemia that can be obtained in Sprague-Dawley rats after the ip administration of doses of 1 to 16 IU calcitonin. The injections caused significant reductions in calcemia in this strain of rats, but did not alter the behavior or general condition of the dosed animals. The method described permits the establishment of experimental models of hypocalcemic rats that will be very useful for physiological and pharmacological studies.
Puerro
M
M
Departmento de Farmacologia, Facultad de Medicina, Universidad Complutense, Madrid, Espana.
Aleixandre
M A
MA
Hernandez
R
R
D000818:Animals; D002116:Calcitonin / Q000008:administration & dosage / Q000633:toxicity*; D006996:Hypocalcemia / Q000139:chemically induced*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D002116:Calcitonin