New insights into actin filament dynamics.
Great progress has been made in advancing an atomic-level model for F-actin. A growing body of data shows, however, that any picture of F-actin must take into account allosteric interactions within subunits, long-range cooperative effects that occur between subunits, and the fact that several conformations of the filament can exist.
Egelman
E H
EH
Department of Cell Biology and Neuroanatomy, University of Minnesota Medical School, Minneapolis 55455, USA.
Orlova
A
A
D008841:Actin Cytoskeleton / Q000737:chemistry* / Q000502:physiology; D000199:Actins / Q000737:chemistry* / Q000378:metabolism*; D000251:Adenosine Triphosphatases / Q000378:metabolism; D000494:Allosteric Regulation; D002118:Calcium / Q000378:metabolism; D018360:Crystallography, X-Ray; D003851:Deoxyribonucleases / Q000378:metabolism; D008958:Models, Molecular; D009218:Myosins / Q000378:metabolism; D011485:Protein Binding; D011487:Protein Conformation; D014335:Tropomyosin / Q000378:metabolism
D000199:Actins; D014335:Tropomyosin; D003851:Deoxyribonucleases; D000251:Adenosine Triphosphatases; D009218:Myosins; D002118:Calcium