[Calciphylaxis].
METHODS
Acute, zigzag-shaped livid skin markings developed on both thighs of a 55-year-old woman who had been on dialysis for 6 years. Within 7 days these areas increased in size to about 10 cm in diameter and contained central dry and painful necroses. On legs, lower arms and hands hard subcutaneous nodules were palpable with a diameter up to 3 mm. For many years the phosphate and parathormone levels, as well as alkaline phosphatase activity had been raised. The patient had often failed to follow treatment recommendations.


METHODS
There were increased serum concentrations of calcium (2.8 mmol/l) and phosphate (1.78 mmol/l). The calcium phosphate ion product was 4.98 (mmol/l)2. Furthermore, there were raised levels of alkaline phosphatase (315 U/l) and parathormone (1076 ng/l, normal: 10-65). X-ray film of the hands showed soft tissue and arterial calcifications, while histological examination of a deep skin biopsy revealed calcium phosphate emboli of the main vessels.


METHODS
Excision of the cutaneous necroses was followed by parathyroidectomy at which only three parathyroid glands were identified and removed. The parathormone level fell postoperatively, but rose again after 4 weeks. The fourth parathyroid gland was then found and removed, after which the parathormone level fell below measurable levels. The skin ulcers healed completely 4 weeks after the second operation.
Proebstle
T M
TM
Abteilung Dermatologie und Venerologie, Universität Ulm sowie Hautklinik der Charité.
Winter
T
T
Hansen-Schmidt
S
S
Weber
L
L
Sterry
W
W
D002115:Calciphylaxis / Q000097:blood / Q000628:therapy; D002118:Calcium / Q000097:blood; D005260:Female; D006801:Humans; D006962:Hyperparathyroidism, Secondary / Q000000981:diagnostic imaging; D052177:Kidney Diseases, Cystic / Q000235:genetics / Q000628:therapy; D008875:Middle Aged; D009336:Necrosis; D010281:Parathyroid Hormone / Q000097:blood; D016105:Parathyroidectomy; D010710:Phosphates / Q000097:blood*; D011859:Radiography; D006435:Renal Dialysis; D012867:Skin / Q000473:pathology
D010281:Parathyroid Hormone; D010710:Phosphates; D002118:Calcium
Calciphylaxie.