Effects of Aspergillus terreus extract on herpes simplex 1 virus replication.
In this study we reported about the antiviral activity of Aspergillus terreus alcohol extract against Herpes simplex type 1 virus. This activity is dose-dependent, is related to the concentration of the challenging virus and depends particularly on a proteic fraction of 5-10 Kda. Optimal effects were observed with doses ranging from 25 to 6.25 micrograms/ml for crude alcohol extract and up to 3 micrograms/ml for 5-10 Kda fraction. Moreover, antiviral activity was evident in viral replication, but not on virus out of the cells. An increased 3H thymidine incorporation was noted on infected cells treated with the extract and this effect may suggest an intracellular accumulation of viral DNA in the absence or reduction of virion production.
Pugliese
A
A
Institute of Infectious Diseases, University of Turin, Italy.
Vidotto
V
V
Comito
G
G
Corgnati
F
F
Torre
D
D
D000998:Antiviral Agents / Q000494:pharmacology*; D001230:Aspergillus / Q000737:chemistry*; D001685:Biological Factors / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008826:Microbial Sensitivity Tests; D014779:Virus Replication / Q000187:drug effects
D000998:Antiviral Agents; D001685:Biological Factors