Characterization of dextromoramide (Palfium) abuse by hair analysis in a denied case.
By providing information on exposure to drugs over time, hair analysis is useful in verifying the history of drug use. In a clinical case, where drug abuse was denied, it was possible to identify dextromoramide in the hair of the subject. After acid hydrolysis of the hair with 0.1 M HCl, in the presence of SKF 525A as an internal standard, the drug was extracted at pH 8.4 with chloroform-isopropanol-n-heptane (50:17:33 v/v) and quantified by gas chromatography/mass spectrometry. The hair strands were cut into 3 sections of 2.5 cm, corresponding to a growth period of 2 months. Concentrations were 1.09, 1.93 and 1.48 ng/mg from the root to the end, respectively. This is the first report on dextromoramide testing in human hair.
Kintz
P
P
Institut de Médecine Légale, Strasbourg, France.
Cirimele
V
V
Edel
Y
Y
Tracqui
A
A
Mangin
P
P
D003916:Dextromoramide / Q000032:analysis* / Q000493:pharmacokinetics; D008401:Gas Chromatography-Mass Spectrometry; D006679:HIV Seropositivity / Q000175:diagnosis / Q000378:metabolism; D006197:Hair / Q000737:chemistry* / Q000378:metabolism; D006556:Heroin Dependence / Q000175:diagnosis / Q000378:metabolism; D006801:Humans; D008297:Male; D009293:Opioid-Related Disorders / Q000175:diagnosis* / Q000378:metabolism; D015813:Substance Abuse Detection; D015819:Substance Abuse, Intravenous / Q000175:diagnosis / Q000378:metabolism
D003916:Dextromoramide