International Commission for Protection Against Environmental Mutagens and Carcinogens. Genetic risk extrapolation from animal data to human disease. A Taskgroup Report. No. 00105.
This report describes a model for producing quantitative genetic risk assessments for human populations. The model is patterned after current methods used in cancer risk analysis. The risk to humans is expressed as the number of additional dominant genetic diseases added to the existing genetic burden, in the offspring of the exposed individuals.
Favor
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Hazleton Washington Inc., Vienna, VA 22182-1699, USA.
Layton
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Sega
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Wassom
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Burkhart
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J
Douglas
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G
Dearfield
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Brusick
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D000818:Animals; D002274:Carcinogens, Environmental / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004781:Environmental Exposure / Q000009:adverse effects; D005799:Genes, Dominant; D018095:Germ-Line Mutation; D006801:Humans; D051379:Mice; D008957:Models, Genetic; D015233:Models, Statistical; D009152:Mutagenicity Tests / Q000379:methods / Q000592:standards; D009153:Mutagens / Q000633:toxicity*; D015203:Reproducibility of Results; D018570:Risk Assessment; D013045:Species Specificity; D014178:Translocation, Genetic
D002274:Carcinogens, Environmental; D009153:Mutagens