title: Increased middle cerebral artery flow velocity during the initial phase of cardiopulmonary bypass may cause neurological dysfunction.
abstract: One hundred twenty-seven patients undergoing coronary artery bypass graft surgery were monitored by transcranial Doppler ultrasonography. Five patients had more than 50% increases in middle cerebral artery mean flow velocity during the initial phase (10-120 sec) of cardiopulmonary bypass. Four of these 5 developed neurological complications including stroke and encephalopathy. These results indicate that overperfusion of the basal cerebral arteries during cardiopulmonary bypass procedures may contribute to neurological dysfunction after the surgery.
authors.affiliation: Department of Medicine, Allegheny General Hospital, Pittsburgh, PA, USA.
authors.forename: J
authors.initials: J
authors.lastname: Brillman
authors.forename: D
authors.initials: D
authors.lastname: Davis
authors.forename: R E
authors.initials: RE
authors.lastname: Clark
authors.forename: T R
authors.initials: TR
authors.lastname: Price
authors.forename: M R
authors.initials: MR
authors.lastname: Lovell
authors.forename: D A
authors.initials: DA
authors.lastname: Benckart
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001007:Anxiety / Q000209:etiology; D001288:Attention; D001783:Blood Flow Velocity; D001927:Brain Diseases / Q000209:etiology*; D002315:Cardiopulmonary Bypass / Q000379:methods; D002536:Cerebral Arteries / Q000000981:diagnostic imaging / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D002561:Cerebrovascular Disorders / Q000209:etiology*; D003072:Cognition Disorders / Q000209:etiology; D005260:Female; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000209:etiology; D007600:Judgment; D007806:Language Disorders / Q000209:etiology; D008297:Male; D008569:Memory Disorders / Q000209:etiology; D008875:Middle Aged; D009949:Orientation; D012189:Retrospective Studies; D017585:Ultrasonography, Doppler, Transcranial