title: Serum-soluble CD23 in patients with endometriosis and the effect of treatment with danazol and leuprolide acetate depot injection.
abstract: Activated B cells have recently been shown to produce soluble CD23 from their membranes. The serum-soluble CD23 concentration in 21 patients with pelvic pain diagnosed as having endometriosis and confirmed by histology, and in 18 patients without pelvic pain, who had a normal pelvis during laparoscopic sterilization, was studied by chemiluminescent enzyme-linked immunosorbent assay. The endometriosis patients were randomized to 3 months of either danazol or leuprolide acetate injection. Serum was taken before and after 3 months of therapy. The serum-soluble CD23 concentration was significantly elevated in patients with endometriosis when compared with the controls (P < 0.0001). There was no correlation between soluble CD23 concentrations and the severity of endometriosis (r = 0.48, P > 0.05). The serum concentration of soluble CD23 decreased significantly on treatment with danazol but not leuprolide acetate (P < 0.05). We conclude that the elevation of soluble CD23 in patients with endometriosis suggests that there is activation of B cells, which respond to danazol but not leuprolide acetate injection.
authors.affiliation: University Department, Jessop Hospital for Women, Sheffield, UK.
authors.forename: O A
authors.initials: OA
authors.lastname: Odukoya
authors.forename: A
authors.initials: A
authors.lastname: Bansal
authors.forename: A P
authors.initials: AP
authors.lastname: Wilson
authors.forename: A P
authors.initials: AP
authors.lastname: Weetman
authors.forename: I D
authors.initials: ID
authors.lastname: Cooke
mesh_terms: D001402:B-Lymphocytes / Q000378:metabolism; D003613:Danazol / Q000008:administration & dosage*; D003692:Delayed-Action Preparations; D004715:Endometriosis / Q000188:drug therapy* / Q000276:immunology; D005260:Female; D006801:Humans; D016729:Leuprolide / Q000008:administration & dosage*; D008213:Lymphocyte Activation; D017455:Receptors, IgE / Q000032:analysis*
chemical_list: D003692:Delayed-Action Preparations; D017455:Receptors, IgE; D016729:Leuprolide; D003613:Danazol