Surgical cure of hypertension in a patient with brainstem capillary haemangioblastoma containing neuropeptide Y.
We describe a 29-year-old woman with persistent arterial hypertension which resolved following complete excision of a capillary haemangioblastoma from within the spinal cord at the cervico-medullary junction. Immunohistochemical staining was positive for neuropeptide Y in capillary walls and nerves in the tumour. This raises the possibility of an association between neuropeptide Y and the central control of blood pressure in man.
Hedderwick
S A
SA
Department of Clinical Pharmacology, UMDS, Medical School Building, Guy's Hospital, London, UK.
Bishop
A E
AE
Strong
A J
AJ
Ritter
J M
JM
D000328:Adult; D001933:Brain Stem / Q000378:metabolism; D002528:Cerebellar Neoplasms / Q000378:metabolism / Q000601:surgery*; D005260:Female; D018325:Hemangioblastoma / Q000150:complications / Q000378:metabolism / Q000601:surgery*; D006801:Humans; D006973:Hypertension / Q000209:etiology / Q000601:surgery*; D007150:Immunohistochemistry; D009478:Neuropeptide Y / Q000378:metabolism*
D009478:Neuropeptide Y