title: Course of thrombocytopenia of chronic liver disease after transjugular intrahepatic portosystemic shunts (TIPS). A retrospective analysis.
abstract: Thrombocytopenia associated with chronic liver disease presents a difficult management issue. Most reports conclude that portocaval and distal splenorenal shunts do not improve platelet counts in this setting. The response of thrombocytopenia after transjugular intrahepatic portosystemic shunt placement has not been studied. All platelet counts of 21 patients undergoing intrahepatic shunt placement were determined retrospectively to accumulate values at one month prior to procedure, weekly for the first month after the procedure, and monthly thereafter to six months. Comparison of pre- and postshunt platelet means showed a significant increase in counts in patients with a postshunt portal pressure gradient < 12 mm Hg, with the increment evident by one week after the procedure. This response was not seen when preshunt thrombocytopenia was used as the lone variable. This study suggests that the transjugular intrahepatic portosystemic shunt may improve the thrombocytopenia associated with liver cirrhosis when these pressure gradients are attained.
authors.affiliation: Department of Medicine, University of Colorado Health Sciences Center, Denver 80262, USA.
authors.forename: S P
authors.initials: SP
authors.lastname: Lawrence
authors.forename: D C
authors.initials: DC
authors.lastname: Lezotte
authors.forename: J D
authors.initials: JD
authors.lastname: Durham
authors.forename: D A
authors.initials: DA
authors.lastname: Kumpe
authors.forename: G T
authors.initials: GT
authors.lastname: Everson
authors.forename: B M
authors.initials: BM
authors.lastname: Bilir
mesh_terms: D000328:Adult; D000368:Aged; D002908:Chronic Disease; D005260:Female; D006801:Humans; D007601:Jugular Veins; D008107:Liver Diseases / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010976:Platelet Count; D017082:Portal Pressure; D011170:Portasystemic Shunt, Surgical; D012189:Retrospective Studies; D013921:Thrombocytopenia / Q000097:blood* / Q000209:etiology