[Is ion-selective measurement of the liver surface for detection of cell damage suitable?--A study of the rat liver transplantation model].
Aim of the study is to detect a reperfusion injury in rat liver transplantation by the Ion-selective Surface-Measurement (OMS).


METHODS
Lewis rats served as models for 30 liver transplantations with 1, 6 or 12 hrs of cold ischemia respectively. Directly before, during and after transplantation potassium- and hydrogen-concentrations were measured with the OMS and compared to transaminase values on day 1, 3 and 7 as well as to biopsies on day 3.


RESULTS
Transaminase values and histology show ischemic cell injuries correlating to the length of ischemia, whereas potassium- and hydrogen-concentrations on the organ surface do not.


CONCLUSIONS
Ischemic cell injury in the rat liver cannot be detected by the Ion-selective Measurement.
Meyer
D
D
Chirurgische Universitätsklinik Würzburg.
Timmermann
W
W
Thiede
A
A
D000136:Acid-Base Equilibrium / Q000502:physiology; D000818:Animals; D002470:Cell Survival / Q000502:physiology*; D006085:Graft Survival / Q000502:physiology; D017736:Ion-Selective Electrodes; D008099:Liver / Q000473:pathology; D008111:Liver Function Tests; D016031:Liver Transplantation / Q000473:pathology / Q000502:physiology*; D015221:Potassium Channels / Q000502:physiology; D051381:Rats; D011917:Rats, Inbred Lew; D014021:Tissue Preservation
D015221:Potassium Channels
Ist die Ionenselektive Messung an der Leberoberfläche zum Nachweis eines Zellschadens geeignet?--Eine Studie am Modell der Rattenlebertransplantation.