[Effect of prostaglandin inhibitors on leukocyte infiltration and on leukocytes in tears after experimental injury of the corneal epithelium].
The effect of drug inhibiting prostaglandin biosynthesis on permeation of leucocytes to tears and cornea after experimental removal of the epithelium was observed. It was shown that 1% indomethacin solution and 0.5% ibuprofen solution considerably decreased the number of leucocytes in tears and their infiltration to the proper substance and negatively affected regeneration of corneal epithelium. The investigations have shown that prostaglandin inhibitors inhibit leucocyte infiltration and may, in effect, decrease the number of proteolytic enzymes that are secreted by these cells.
Toczołowski
J
J
II Kliniki Okulistyki AM w Lublinie.
Katski
W
W
D000818:Animals; D003315:Cornea / Q000187:drug effects / Q000473:pathology / Q000502:physiology*; D004848:Epithelium / Q000187:drug effects / Q000473:pathology / Q000502:physiology; D007052:Ibuprofen / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007958:Leukocyte Count / Q000187:drug effects; D007962:Leukocytes / Q000187:drug effects*; D011448:Prostaglandin Antagonists / Q000494:pharmacology*; D011817:Rabbits; D012038:Regeneration / Q000187:drug effects*; D013666:Tears / Q000166:cytology / Q000187:drug effects*
D011448:Prostaglandin Antagonists; D007052:Ibuprofen; D007213:Indomethacin
Wpływ inhibitorów prostaglandyn na naciek leukocytarny i na leukocyty w łzach po doświadczalnym uszkodzeniu nabłonka rogówki.