Effect of piroxicam beta-cyclodextrin complex on experimental inflammation.
1. The effectiveness of the inclusion product of piroxicam with beta-cyclodextrin was compared to that of free piroxicam on inflammatory reactions by using three experimental inflammatory models in rats. 2. The inclusion compound showed anti-inflammatory effects similar to those of simple piroxicam on granuloma tissue formation and arthritis induced by complete Freund adjuvant. 3. In carrageenin-induced pleurisy, the piroxicam beta-cyclodextrin reduced leukocyte mobilization more intensely than non-complexed piroxicam. 4. These results suggest that beta-cyclodextrin is a useful tool for improving the efficacy of piroxicam.
Amado
C A
CA
Depto. de Farmácia e Farmacologia, Universidade de Maringá, Paraná, Brazil.
Taniguchi
S F
SF
Sudo
L S
LS
Kimura
E
E
Oga
S
S
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001169:Arthritis, Experimental / Q000188:drug therapy; D002351:Carrageenan; D003505:Cyclodextrins / Q000494:pharmacology*; D005620:Freund's Adjuvant; D003368:Gossypium; D006099:Granuloma / Q000139:chemically induced / Q000188:drug therapy; D008297:Male; D010894:Piroxicam / Q000494:pharmacology*; D010998:Pleurisy / Q000139:chemically induced / Q000188:drug therapy; D051381:Rats; D017208:Rats, Wistar; D047392:beta-Cyclodextrins
D000894:Anti-Inflammatory Agents, Non-Steroidal; D003505:Cyclodextrins; D047392:beta-Cyclodextrins; D010894:Piroxicam; D002351:Carrageenan; D005620:Freund's Adjuvant; C031215:betadex