title: Production of the new antibiotic tetrahydrokalafungin by transformants of the kalafungin producer Streptomyces tanashiensis.
abstract: The new antibiotic tetrahydrokalafungin was produced by the transformants of kalafungin producing S. tanashiensis and kalafungin-nonproducing mutants carrying the recombinant plasmid pKU523. This plasmid consists of pKU501 (J. Antibiotics 44: 995 approximately 1005, 1991) which contains the gene cluster for kalafungin biosynthesis, and additional 5 kb stability region of SCP2*.
authors.affiliation: School of Pharmaceutical Sciences, Kitasato University, Kitasato Institute, Tokyo, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Kakinuma
authors.forename: H
authors.initials: H
authors.lastname: Ikeda
authors.forename: Y
authors.initials: Y
authors.lastname: Takada
authors.forename: H
authors.initials: H
authors.lastname: Tanaka
authors.forename: D A
authors.initials: DA
authors.lastname: Hopwood
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D010957:Plasmids; D013302:Streptomyces / Q000235:genetics; D013329:Structure-Activity Relationship; D000095622:Benzoisochromanequinones
chemical_list: D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; C094830:tetrahydrokalafungin; C013079:kalafungin; D000095622:Benzoisochromanequinones