title: Differences in mossy fibre sprouting during conventional and rapid amygdala kindling of the rat.
abstract: The effect of conventional and rapid amygdala kindling on mossy fibre sprouting and on the development of secondary after-discharges in the hippocampus, i.e. recurring after-discharges after the end of primary after-discharges in the amygdala, was investigated. Rapid kindling, i.e. electric stimulation of the amygdala for 10 s every 30 min, induced prolonged secondary after-discharges in the hippocampus, which occurred after the first stimulation, and mossy fibre sprouting. Conventional kindling, i.e. electric stimulation of the amygdala for 1 s once daily, induced secondary after-discharges in the hippocampus only after prolonged motor seizures, but no mossy fibre sprouting. These results suggest that mossy fibre sprouting and the occurrence of secondary after-discharges in the hippocampus are not crucial for conventional amygdala kindling. Rapid kindling induces these epileptogenic changes in the hippocampus very early and may therefore follow a different route of epileptogenesis than conventional kindling.
authors.affiliation: Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany.
authors.forename: U
authors.initials: U
authors.lastname: Ebert
authors.forename: W
authors.initials: W
authors.lastname: Löscher
mesh_terms: D000679:Amygdala / Q000502:physiology*; D000818:Animals; D002452:Cell Count; D004195:Disease Models, Animal; D004558:Electric Stimulation; D004833:Epilepsy, Temporal Lobe / Q000209:etiology; D005260:Female; D006624:Hippocampus / Q000033:anatomy & histology / Q000502:physiology*; D007696:Kindling, Neurologic; D008297:Male; D009412:Nerve Fibers / Q000502:physiology; D009474:Neurons / Q000166:cytology / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000209:etiology