Injectable bone marrow preparations to stimulate osteogenic repair.
The great versatility of bone marrow transplants based on stem cell activity has been demonstrated successfully for a variety of previously untreatable hemopoietic conditions. Autologous bone marrow delivered by percutaneous injection or by direct transplant as a composite graft also has proven effective for osteogenic stimulation in a series of 100 skeletal healing problems, including delayed unions and nonunions of fractures, arthrodeses, and bone defects. The efficiency of marrow to form bone can be increased by a number of methods, including differential centrifugation and composite grafts of marrow with demineralized bone matrix and other carriers or stimulatory factors.
Connolly
J F
JF
Department of Orthopaedic Surgery, Orlando Regional Healthcare System, Orlando, FL 32806, USA.
D000818:Animals; D001174:Arthrodesis / Q000379:methods*; D018775:Bone Demineralization Technique; D001847:Bone Diseases / Q000628:therapy*; D016026:Bone Marrow Transplantation; D001857:Bone Matrix / Q000637:transplantation*; D017102:Fracture Healing; D005599:Fractures, Ununited / Q000628:therapy*; D018380:Hematopoietic Stem Cell Transplantation; D006801:Humans