title: Healing process of sutureless choledochojejunostomy in an experimental model.
abstract: The healing characteristics and morphological features of sutureless choledochojejunostomy were investigated in a rat experimental model. The common bile duct of 34 conditioned Wistar rats was exposed, divided transversely and a choledochojejunostomy constructed with only a vinyl chloride tube positioned between the common duct and jejunum. The animals were killed 4, 12 and 52 weeks after surgery. Cholangiographic evaluation of the anastomosis in all three groups showed wide openings with dilatation of the extrahepatic bile duct. Microscopic examination of the anastomosis showed hyperplastic changes of the bile duct epithelium. The epithelial defect was completely covered with proliferative epithelium 12 weeks after operation. At long-term follow-up of 52 weeks there were no biliary strictures after the sutureless technique. This surgical approach may be useful for patients in whom sutured anastomosis of the bile duct might lead to stricture, such as those with a normal thin-walled bile duct.
authors.affiliation: Second Department of Surgery, Faculty of Medicine, University of Tokyo, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ishizaki
authors.forename: Y
authors.initials: Y
authors.lastname: Bandai
authors.forename: K
authors.initials: K
authors.lastname: Shimomura
authors.forename: Y
authors.initials: Y
authors.lastname: Idezuki
authors.forename: M
authors.initials: M
authors.lastname: Makuuchi
mesh_terms: D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D001219:Aspartate Aminotransferases / Q000097:blood; D017734:Bile Ducts, Extrahepatic / Q000033:anatomy & histology; D002758:Cholangiography; D002768:Choledochostomy / Q000379:methods*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D014945:Wound Healing
chemical_list: D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase