Splanchnic metabolism associated with liver metastasis.
Metastatic liver disease can modify the metabolic response to critical illness. Systemic lactic acidosis may arise from an increased production due to inadequate peripheral tissue oxygen transport, altered metabolic function such as depressed pyruvate oxidation or insufficient hepatic clearing capacity due to tumor replacement of functional liver mass. Hepatic venous catheterization in a patient with extensive metastatic melanoma to the liver and adult respiratory distress syndrome indicated a marked disparity between whole body and liver oxygenation which may arise due to a markedly stepped up splanchnic oxygen utilization unmatched by a proportionate rise in regional oxygen delivery. Since some neoplasms may exhibit increased metabolic activity, it is suspected that these metastatic lesions may have contributed to the observed regional hypermetabolism thereby worsening hepatic hypoxia and exacerbating lactic acidosis. This case also illustrates the difficulties in interpreting global indicators of metabolic function and oxygenation in critically ill patients.
Dahn
M S
MS
Department of Surgery, University Health Center, Detroit, MI 48201, USA.
Lange
M P
MP
Kosir
M A
MA
D000140:Acidosis, Lactic / Q000097:blood / Q000150:complications; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008099:Liver / Q000378:metabolism / Q000473:pathology; D008113:Liver Neoplasms / Q000150:complications / Q000378:metabolism* / Q000556:secondary; D008545:Melanoma / Q000150:complications / Q000378:metabolism* / Q000556:secondary; D008659:Metabolic Diseases / Q000378:metabolism*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D010101:Oxygen Consumption; D013152:Splanchnic Circulation; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood / Q000150:complications