title: [Effect of nedocromil sodium on clinical course and histamine airway responsiveness in patients with pollen induced bronchial asthma].
abstract: Nedocromil sodium is a non-steroidal prophylactic agent for the management of asthma. We assessed the effect of inhaled of nedocromil sodium 8 mg/24 h in a double blind, placebo controlled study in 14 patients suffering from seasonal (grass-pollen) asthma. Symptom scores for dyspnoe, cough, rhinitis and airway responsiveness to histamine (PC20H) according to Cockcroft et al were estimated before the grass-pollen season and at the end of 14-day placebo treatment and 21-day nedocromil sodium treatment. During placebo period the significant decrease in PC20H from 1.81 mg/ml to 0.54 mg/ml (p < 0.01) was observed. Nedocromil sodium did not have the effect on nonspecific bronchial responsiveness, PC20 - 0.74 mg/ml (p = 0.25). Subjective global assessment scores were significantly better with nedocromil sodium (31.15 mean 2.23) than with placebo (10.5 mean 0.7) p < 0.05.
authors.affiliation: Oddziału Ftizjopneumonologii Kliniki Pneumonologii i Alergologii IMW AM w Lodzi.
authors.forename: I
authors.initials: I
authors.lastname: Grzelewska-Rzymowska
authors.forename: W
authors.initials: W
authors.lastname: Grabski
authors.forename: J
authors.initials: J
authors.lastname: Kroczyńska-Bednarek
authors.forename: M
authors.initials: M
authors.lastname: Zieba
authors.forename: J
authors.initials: J
authors.lastname: Rozniecki
mesh_terms: D000328:Adult; D001249:Asthma / Q000188:drug therapy* / Q000209:etiology; D001985:Bronchial Provocation Tests; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D017835:Nedocromil / Q000627:therapeutic use*; D012123:Pulmonary Ventilation / Q000187:drug effects; D006255:Rhinitis, Allergic, Seasonal / Q000150:complications*; D016896:Treatment Outcome
chemical_list: D017835:Nedocromil
vernacular_title: Wpływ nedokromilu sodu na przebieg kliniczny i nieswoista reaktywność oskrzeli na histamine u chorych na pyłkowa astme oskrzelowa.