Synthesis and in vivo hypoglycemic screening studies on some life essential metal complexes of oral antidiabetic [N-(p-tolylsulphonyl)-N'-n butyl-urea] (tolbutamide).
Present communication deals with the synthesis of complexes of [N-(p-tolylsulphonyl)-N'-n butyl-urea], with certain transition metals viz. Cu(II), Zn(II), Fe(II) and Cd(II). Structures of all the complexes have been established on the basis of their consistent elemental and spectral analysis. Also, it reports their in vivo hypoglycemic screening on albino rats. Out of all the complexes studied, Zn-Tolbutamide complex could be recommended as more potent hypoglycemic agent in lieu of tolbutamide alone.
Narad
S R
SR
Microanalysis Laboratory, School of Chemistry, Devi Ahilya University, Indore.
Mishra
N N
NN
Pandey
P
P
Kumar
A
A
Pitre
K S
KS
D000284:Administration, Oral; D000818:Animals; D002104:Cadmium / Q000737:chemistry; D003300:Copper / Q000737:chemistry; D004357:Drug Synergism; D007003:Hypoglycemia / Q000188:drug therapy*; D007501:Iron / Q000737:chemistry; D051381:Rats; D013055:Spectrophotometry, Infrared; D014044:Tolbutamide / Q000008:administration & dosage / Q000737:chemistry / Q000627:therapeutic use*; D015032:Zinc / Q000737:chemistry
D002104:Cadmium; D003300:Copper; D014044:Tolbutamide; D007501:Iron; D015032:Zinc