Brevitaxin, a new diterpenolignan from the bark of Taxus brevifolia.
The first terpenolignan, brevitaxin [1], has been isolated from the bark of Taxus brevifolia. Identification was carried out using spectral methods, and the regiochemistry and cytotoxicity of 1 are discussed.
Arslanian
R L
RL
Hauser Chemical Research, Inc., Boulder, Colorado 80301, USA.
Bailey
D T
DT
Kent
M C
MC
Richheimer
S L
SL
Thornburg
K R
KR
Timmons
D W
DW
Zheng
Q Y
QY
D000972:Antineoplastic Agents, Phytogenic / Q000302:isolation & purification* / Q000494:pharmacology; D004224:Diterpenes / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D017705:Lignans / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D010946:Plants, Medicinal / Q000737:chemistry*; D014407:Tumor Cells, Cultured
D000972:Antineoplastic Agents, Phytogenic; D004224:Diterpenes; D017705:Lignans; C094788:brevitaxin