title: Suture closure in the human chondrocranium: CT assessment.
abstract: OBJECTIVE
  To chronicle the development of ossification centers, sutures, and synchondroses in the chondrocranium throughout childhood by using computed tomography (CT).
  
  
  METHODS
  One hundred eighty-nine children (age range, newborn to 18 years; median age, 4.0 years) without skull base deformity were referred for cranial CT. The closure of 18 sutures and synchondroses was graded.
  
  
  RESULTS
  In the occipital bone at birth, six components were identified. The Kerckring ossicle rapidly fused to the supraoccipital bone within the 1st month. At age 1-3 years, the posterior and anterior intraoccipital synchondroses began to fuse. The occipitomastoidal, petro-occipital, and spheno-occipital synchondroses remained partially open into the teenage years. In the sphenoid bone at birth, 13 ossification centers were identified; most assimilated into the sphenoidal body during the first 2 years. Pneumatization of the sphenoid sinus appeared at age 1-2 years and advanced posteriorly over the next 3-5 years.
  
  
  CONCLUSIONS
  The complex process of skull base development is chronicled, which provides CT standards for judgment of the patterns and timing of sutural or synchondrosal closure.
authors.affiliation: Department of Radiology, Bowman Gray School of Medicine, Wake Forest University, Winston-Salem, NC 27157-1022, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Madeline
authors.forename: A D
authors.initials: AD
authors.lastname: Elster
mesh_terms: D000293:Adolescent; D000375:Aging; D001862:Bone Resorption / Q000000981:diagnostic imaging; D002648:Child; D002675:Child, Preschool; D003393:Cranial Sutures / Q000000981:diagnostic imaging / Q000254:growth & development*; D005260:Female; D005539:Foramen Magnum / Q000000981:diagnostic imaging / Q000254:growth & development; D005624:Frontal Bone / Q000000981:diagnostic imaging / Q000254:growth & development; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007223:Infant; D007231:Infant, Newborn; D008297:Male; D008416:Mastoid / Q000000981:diagnostic imaging / Q000254:growth & development; D009777:Occipital Bone / Q000000981:diagnostic imaging / Q000254:growth & development; D010012:Osteogenesis; D010579:Petrous Bone / Q000000981:diagnostic imaging / Q000254:growth & development; D012189:Retrospective Studies; D013100:Sphenoid Bone / Q000000981:diagnostic imaging / Q000254:growth & development; D014057:Tomography, X-Ray Computed