Hormonal replacement therapy and morbidity and mortality in a prospective study of postmenopausal women.
We assessed the association of hormonal replacement therapy with mortality and incidence of multiple diseases in over 40,000 postmenopausal women followed for 6 years as part of the Iowa Women's Health Study. Compared with women who never used hormone replacement therapy, current users had multivariate adjusted relative risks (RR) as follows: total mortality (RR = 0.78; 95% confidence interval [CI] = 0.65, 0.94), coronary heart disease mortality (RR = 0.74; 95% CI = 0.48, 1.12), endometrial cancer incidence (RR = 4.3; 95% CI = 2.7, 6.9), breast cancer incidence (RR = 1.23; 95% CI = 0.99, 1.55), colon cancer incidence (RR = 0.72; 95% CI = 0.46, 1.12), and hip fracture incidence (RR = 0.53; 95% CI = 0.31, 0.91).
Folsom
A R
AR
Division of Epidemiology, School of Public Health, University of Minnesota, Minneapolis 55454-1015, USA.
Mink
P J
PJ
Sellers
T A
TA
Hong
C P
CP
Zheng
W
W
Potter
J D
JD
D002318:Cardiovascular Diseases / Q000453:epidemiology*; D015914:Estrogen Replacement Therapy; D005260:Female; D050723:Fractures, Bone / Q000453:epidemiology; D006620:Hip Fractures / Q000453:epidemiology; D006801:Humans; D015994:Incidence; D007484:Iowa / Q000453:epidemiology; D008875:Middle Aged; D009026:Mortality; D009369:Neoplasms / Q000453:epidemiology*; D017698:Postmenopause; D011446:Prospective Studies; D012306:Risk; D016387:Women's Health