Association between clozapine response and allelic variation in 5-HT2A receptor gene.
We report allelic association between a polymorphism (T102C) within the coding region of the 5-HT2A gene (HTR2A, 13q14-21) and response to clozapine in schizophrenic patients. Homozygosity for the C102 allele was more frequent (30/57, 53%) among patients who did not respond to clozapine than in those who responded (23/92, 25%). This finding is evidence that allelic variation of genes which encode neurotransmitter receptors can influence clinical response to antipsychotic drugs.
Arranz
M
M
Section of Molecular Genetics, Institute of Psychiatry, London, UK.
Collier
D
D
Sodhi
M
M
Ball
D
D
Roberts
G
G
Price
J
J
Sham
P
P
Kerwin
R
R
D000483:Alleles; D001483:Base Sequence; D003024:Clozapine / Q000494:pharmacology* / Q000627:therapeutic use; D017931:DNA Primers; D005260:Female; D014644:Genetic Variation / Q000187:drug effects*; D005838:Genotype; D006720:Homozygote; D006801:Humans; D008297:Male; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic / Q000187:drug effects; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000235:genetics*; D012559:Schizophrenia / Q000188:drug therapy / Q000235:genetics
D017931:DNA Primers; D044402:Receptor, Serotonin, 5-HT2A; D011985:Receptors, Serotonin; D003024:Clozapine