Antiviral activities of isometric dideoxynucleosides of D- and L-related stereochemistry.
In summary, many isomeric analogs of ddNs of both D-related and L-related absolute stereochemistries have been synthesized and evaluated in vitro for their antiviral activities. A few of these compounds exhibit potent antiviral activity and, interestingly, belong to both the D and L families. The synthetic methodologies developed will allow accessibility to many more novel modified nucleosides. While some structure-activity relationships are emerging from this work, it is clear that these chiral isomeric nucleosides have opened a new chapter in the field of antiviral nucleosides.
Nair
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Department of Chemistry, University of Iowa, Iowa City 52242, USA.
Jahnke
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D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D015224:Dideoxynucleosides / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D013237:Stereoisomerism
D000998:Antiviral Agents; D015224:Dideoxynucleosides