Analysis of tissue organization by microinjection of follistatin into early Xenopus laevis embryos.
Xenopus laevis embryos injected with follistatin developed abnormally with enlarged anterior structures and defective tails. Histological sections reveal that these follistatin treated embryos contain large amount of notochordal tissue that fails to elongate. Embryonic responses to follistatin are dose and stage specific. These results suggested that follistatin contributes to body axis formation, with its most visible effect on notochord formation.
Lau
C L
CL
Department of Pathobiology, University of Pennsylvania, Philadelphia 19104-6008, USA.
D000818:Animals; D001368:Axis, Cervical Vertebra / Q000187:drug effects / Q000196:embryology; D002454:Cell Differentiation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004625:Embryo, Nonmammalian / Q000187:drug effects*; D038681:Follistatin; D006023:Glycoproteins / Q000494:pharmacology*; D014982:Xenopus laevis / Q000196:embryology*
D038681:Follistatin; D006023:Glycoproteins