A novel phorbol ester from Excoecaria agallocha.
The novel phorbol ester 12-deoxyphorbol 13-(3E,5E-decadienoate) [1] was isolated as the anti-HIV principle of Excoecaria agallocha leaves and stems collected in northwest Australia. The structure was determined by spectral means. Compound 1 was also a potent displacer of [3H]-phorbol dibutyrate from rat brain membranes.
Erickson
K L
KL
Laboratory of Drug Discovery Research and Development, National Cancer Institute, NCI-FCRDC, Maryland 21702-1201, USA.
Beutler
J A
JA
Cardellina
J H
JH
McMahon
J B
JB
Newman
D J
DJ
Boyd
M R
MR
D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002853:Chromatography, Liquid; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D010703:Phorbol Esters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D014779:Virus Replication / Q000187:drug effects
C094712:12-deoxyphorbol 13-(3,5-decadienoate); D000998:Antiviral Agents; D010703:Phorbol Esters