title: Transferable resistance to cefotaxime in nosocomial Klebsiella pneumoniae and Escherichia coli strains due to their production of extended-spectrum beta-lactamase in Slovakia.
abstract: Transferable resistance to cefotaxime was demonstrated in 21 nosocomial strains of Klebsiella pneumoniae and Escherichia coli subsequently isolated from patients in two large University clinics. Using the double-disk diffusion test, we could detect, in each such strain, as well as in E. coli 3110 K-12 transconjugants after the transfer, the production of an Extended Spectrum Beta-Lactamase (ESBL). Ceftibuten was demonstrated to be effective against the majority of strains studied.
authors.affiliation: Institute of Preventive & Clinical Medicine, Bratislava, Slovak Republic.
authors.forename: M
authors.initials: M
authors.lastname: Hupková
authors.forename: J
authors.initials: J
authors.lastname: Blahová
authors.forename: M
authors.initials: M
authors.lastname: Babálová
authors.forename: V
authors.initials: V
authors.lastname: Krcméry
authors.forename: K
authors.initials: K
authors.lastname: Králiková
mesh_terms: D002439:Cefotaxime / Q000378:metabolism / Q000494:pharmacology*; D000077722:Ceftibuten; D002511:Cephalosporins / Q000494:pharmacology; D003227:Conjugation, Genetic / Q000235:genetics; D003428:Cross Infection / Q000382:microbiology*; D004352:Drug Resistance, Microbial / Q000235:genetics; D004926:Escherichia coli / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D004927:Escherichia coli Infections / Q000382:microbiology; D006801:Humans; D006868:Hydrolysis; D007710:Klebsiella Infections / Q000382:microbiology; D007711:Klebsiella pneumoniae / Q000187:drug effects* / Q000201:enzymology* / Q000235:genetics; D008826:Microbial Sensitivity Tests; D018154:Slovakia; D001618:beta-Lactamases / Q000096:biosynthesis*
chemical_list: D002511:Cephalosporins; D001618:beta-Lactamases; D000077722:Ceftibuten; D002439:Cefotaxime