title: Renal transplantation in patients with posterior urethral valves: favorable long-term outcome.
abstract: OBJECTIVE
  We assessed the long-term efficacy of renal transplantation in patients with posterior urethral valves.
  
  
  METHODS
  We reviewed the outcome in 23 patients with posterior urethral valves who underwent renal transplantation since 1979.
  
  
  RESULTS
  Graft survival was 69% at 5 years and 63% at 10 years. Seven patients with followup of 7 years or longer had a mean serum creatinine level of 1.5 mg/dl. Three patients (13%) demonstrated significant bladder dysfunction postoperatively.
  
  
  CONCLUSIONS
  Renal transplantation into a valve bladder is not associated with an abnormally high rate of failure. Deterioration of graft function secondary to lower urinary tract dysfunction is uncommon, with the majority of patients able to use the unmodified native bladder as a receptacle for the transplanted kidney.
authors.affiliation: Department of Urology, University of California School of Medicine, San Francisco, USA.
authors.forename: J A
authors.initials: JA
authors.lastname: Connolly
authors.forename: B
authors.initials: B
authors.lastname: Miller
authors.forename: P N
authors.initials: PN
authors.lastname: Bretan
mesh_terms: D000293:Adolescent; D002675:Child, Preschool; D003404:Creatinine / Q000097:blood; D005500:Follow-Up Studies; D006085:Graft Survival; D006801:Humans; D016030:Kidney Transplantation; D011183:Postoperative Complications; D016896:Treatment Outcome; D014521:Urethra / Q000002:abnormalities*; D014524:Urethral Obstruction / Q000601:surgery
chemical_list: D003404:Creatinine