Effects of cocaine on cortisol secretion in humans.
The effects of acute cocaine administration on the pituitary adrenal axis in humans without a history of drug abuse are unknown. The authors studied 12 male volunteers twice in a double-blinded, placebo-controlled, randomized fashion. After intranasal administration of 2 mg/kg cocaine, cortisol levels were significantly higher than after placebo administration. The authors concluded that acute administration of cocaine to humans increases cortisol secretion.
Heesch
C M
CM
Department of Internal Medicine (Division of Cardiology), University of Texas Southwestern Medical Center, Dallas, USA.
Negus
B H
BH
Keffer
J H
JH
Snyder
R W
RW
Risser
R C
RC
Eichhorn
E J
EJ
D000281:Administration, Intranasal; D000324:Adrenocorticotropic Hormone / Q000097:blood; D000328:Adult; D003042:Cocaine / Q000008:administration & dosage*; D004311:Double-Blind Method; D006801:Humans; D006854:Hydrocortisone / Q000097:blood / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000187:drug effects* / Q000378:metabolism
D000324:Adrenocorticotropic Hormone; D003042:Cocaine; D006854:Hydrocortisone