Salfredins, new aldose reductase inhibitors produced by Crucibulum sp. RF-3817. I. Fermentation, isolation and structures of salfredins.
New inhibitors of aldose reductase, designated salfredins A3, A4, A7, C1, C2, C3 and B11, were isolated from the fermentation broth of Crucibulum sp. RF-3817 by successive purification procedures of solvent extraction, silica gel column chromatographies and reverse-phase HPLC. Their structures were established by spectroscopic methods, including UV, SI-MS and NMR. The structures of salfredins A4 and B11 were confirmed by X-ray crystallographic analysis.
Matsumoto
K
K
Shionogi Research Laboratories, Shionogi & Co., Ltd., Osaka, Japan.
Nagashima
K
K
Kamigauchi
T
T
Kawamura
Y
Y
Yasuda
Y
Y
Ishii
K
K
Uotani
N
N
Sato
T
T
Nakai
H
H
Terui
Y
Y
D000449:Aldehyde Reductase / Q000037:antagonists & inhibitors*; D000818:Animals; D001487:Basidiomycota / Q000378:metabolism; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification*; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004791:Enzyme Inhibitors / Q000737:chemistry / Q000302:isolation & purification*; D005285:Fermentation; D007211:Indoles / Q000737:chemistry / Q000302:isolation & purification*; D015394:Molecular Structure; D051381:Rats; D013329:Structure-Activity Relationship
D001578:Benzopyrans; D004791:Enzyme Inhibitors; D007211:Indoles; D000449:Aldehyde Reductase