[The role of fatty acids in gene regulation. An example of an important nutritional factor which may influence our genes].
Regulation of gene expression by specific nutrients has become a major field of nutrition research. Evidence is presented showing that dietary constituents specifically modulate gene transcription and transcript processing. The peroxisome proliferator-activated receptor (PPAR) is a member of the steroid hormone receptor superfamily and is activated by a variety of hypolipidemic drugs, termed peroxisome proliferators. Several genes have been shown to contain elements responsive to peroxisome proliferator-activated receptor. These include the genes that encode the peroxisomal enzymes involved in beta-oxidation of fatty acids. The retinoid receptor X is required, however, for PPAR to bind to its responsive element. The finding that fatty acids are PPAR activators suggests that fatty acids or their acyl CoA-derivatives may regulate the lipid metabolism via this receptor.
Endresen
M J
MJ
Ernaeringsinstituttet, Blindern, Oslo.
D005227:Fatty Acids / Q000378:metabolism / Q000502:physiology*; D005786:Gene Expression Regulation; D006801:Humans; D018160:Receptors, Cytoplasmic and Nuclear / Q000378:metabolism / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism / Q000502:physiology*
D005227:Fatty Acids; D018160:Receptors, Cytoplasmic and Nuclear; D014157:Transcription Factors
Fettsyrenes rolle i genreguleringen. Et eksempel på et viktig naeringsstoff som kan påvirke våre gener.