Lipid peroxidation and vitamin E in red blood cells and plasma in hemodialysis patients under rhEPO treatment.
Lipid peroxidation, measured by malonyldialdehyde (MDA) and vitamin E in red blood cells (RBC) and plasma, was investigated in 25 hemodialysis (HD) patients before and after 6 months rhEPO therapy. RBC-MDA was significantly elevated, but plasma MDA was in the reference range. After recombinant human erythropoietin (rhEPO) treatment, the MDA level was significantly decreased in both compartments. Marked vitamin E deficiency was established in RBC as well as in plasma. rhEPO therapy restored vitamin E levels in both compartments. Our data suggest a possible positive rhEPO-antioxidant effect in HD patients.
Nenov
D
D
Medical University, Varna, Bulgaria.
Paskalev
D
D
Yankova
T
T
Tchankova
P
P
D000293:Adolescent; D000328:Adult; D000975:Antioxidants / Q000627:therapeutic use; D016022:Case-Control Studies; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism*; D004921:Erythropoietin / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006400:Hematocrit; D006454:Hemoglobins / Q000032:analysis; D006801:Humans; D007279:Injections, Subcutaneous; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000097:blood; D008875:Middle Aged; D010949:Plasma / Q000187:drug effects / Q000378:metabolism*; D011994:Recombinant Proteins; D006435:Renal Dialysis; D013921:Thrombocytopenia / Q000097:blood; D014810:Vitamin E / Q000097:blood*; D014811:Vitamin E Deficiency / Q000097:blood
D000975:Antioxidants; D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin; D014810:Vitamin E; D008315:Malondialdehyde