title: Thrombolysis in arterial graft thrombosis.
abstract: OBJECTIVE
  to assess the impact of peripheral arterial thrombolysis for vascular graft occlusion.
  
  
  METHODS
  Retrospective review.
  
  
  METHODS
  University Hospital.
  
  
  METHODS
  Thirty-one patients presented with 33 episodes of graft thrombosis.
  
  
  METHODS
  Successful thrombolysis in terms of total clearance or sufficient clearance to reveal an underlying factor responsible for graft failure.
  
  
  RESULTS
  Thrombolysis was successful in seven of 10 suprainguinal grafts (4 of 5 rtPA; 3 of 5 SK). One patient had failed lysis requiring an ilio-femoral graft. Of the seven patients with successful lysis, one required revision of a proximal anastomosis, two required distal anastomotic revisions, and one rethrombosed. Twenty-three thrombosed infrainguinal grafts were managed initially with intraarterial thrombolysis (9rtPA, 14 SK). Of 27 patients surviving at 30 days, seven required major amputation despite aggressive intervention.
  
  
  CONCLUSIONS
  Thrombosed suprainguinal grafts are amenable to thrombolysis and adjunctive surgery when necessary, with no major haemorrhagic complications. The majority of patients with thrombosed infrainguinal grafts require surgical intervention in order to preserve, or establish long term patency. For polytetrafluoroethylene (PTFE) grafts, thrombolysis was associated with poor success, haemorrhagic complications and a high amputation rate.
authors.affiliation: Academic Surgical Unit, St Mary's Hospital, London, U.K.
authors.forename: D C
authors.initials: DC
authors.lastname: Berridge
authors.forename: A
authors.initials: A
authors.lastname: al-Kutoubi
authors.forename: A O
authors.initials: AO
authors.lastname: Mansfield
authors.forename: A N
authors.initials: AN
authors.lastname: Nicolaides
authors.forename: J H
authors.initials: JH
authors.lastname: Wolfe
mesh_terms: D000671:Amputation, Surgical; D000714:Anastomosis, Surgical / Q000379:methods; D001158:Arteries / Q000601:surgery; D001807:Blood Vessel Prosthesis; D005260:Female; D006083:Graft Occlusion, Vascular / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D007269:Injections, Intra-Arterial; D008297:Male; D008875:Middle Aged; D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D012008:Recurrence; D012086:Reoperation; D012189:Retrospective Studies; D013300:Streptokinase / Q000008:administration & dosage / Q000627:therapeutic use; D015996:Survival Rate; D015912:Thrombolytic Therapy; D013927:Thrombosis / Q000188:drug therapy* / Q000601:surgery; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage / Q000627:therapeutic use; D014654:Vascular Patency; D014680:Veins / Q000637:transplantation
chemical_list: D011093:Polyethylene Terephthalates; D011138:Polytetrafluoroethylene; D013300:Streptokinase; D010959:Tissue Plasminogen Activator