title: Control of infection with multiple antibiotic resistant bacteria in a hospital renal unit: the value of plasmid characterization.
abstract: An outbreak of infections due to multiple antibiotic-resistant bacteria took place over a period of approximately 18 months in a renal unit. Strains of Escherichia coli, Enterobacter aerogenes, Klebsiella pneumoniae, Citrobacter spp. and Pseudomonas spp. were involved, and a variety of antibiotic resistances was encountered. Closely related plasmids encoding resistance to aztreonam, ceftazidime and piperacillin, possibly derived from an archetypal plasmid of 105 kb were found in the majority of isolates examined. After limiting the use of aztreonam the incidence of new patient isolates of multiple-resistant organisms was greatly reduced. This study demonstrated how molecular studies can contribute to the control of an outbreak situation in a hospital unit by providing an impetus to reduce the use of specific antibiotics.
authors.affiliation: Department of Medical Microbiology, St. Mary's Hospital Medical School, London, U.K.
authors.forename: C S
authors.initials: CS
authors.lastname: Reed
authors.forename: S P
authors.initials: SP
authors.lastname: Barrett
authors.forename: E J
authors.initials: EJ
authors.lastname: Threlfall
authors.forename: T
authors.initials: T
authors.lastname: Cheasty
mesh_terms: D003428:Cross Infection / Q000188:drug therapy / Q000453:epidemiology* / Q000517:prevention & control*; D004196:Disease Outbreaks / Q000517:prevention & control*; D018432:Drug Resistance, Multiple; D006090:Gram-Negative Bacteria / Q000145:classification / Q000187:drug effects / Q000302:isolation & purification; D006757:Hospital Units; D006801:Humans; D011815:R Factors / Q000235:genetics / Q000302:isolation & purification; D012621:Seasons; D006113:United Kingdom / Q000453:epidemiology