Retinol transport and metabolism in transthyretin-"knockout" mice.
Mice were made deficient in transthyretin (TTR), the protein that normally transports plasma retinol complexed with retinol-binding protein (RBP), by targeted mutagenesis (TTR-knockout mice). The TTR- mice were healthy and fertile, despite extremely low plasma retinol and RBP levels (6% of wild type). Circulating retinoic acid was 2.3 times that of wild-type controls. Liver levels of RBP were 60% higher in the TTR-mutants compared to wild-type mice, suggesting that lack of TTR may block secretion of RBP-retinol from liver.
Wolf
G
G
Department of Nutritional Sciences, University of California, Berkeley 94720, USA.
D000818:Animals; D001692:Biological Transport; D008099:Liver / Q000378:metabolism; D051379:Mice; D018345:Mice, Knockout; D016296:Mutagenesis; D011228:Prealbumin / Q000172:deficiency* / Q000235:genetics / Q000502:physiology; D012177:Retinol-Binding Proteins / Q000378:metabolism; D054839:Retinol-Binding Proteins, Plasma; D014212:Tretinoin / Q000097:blood; D014801:Vitamin A / Q000378:metabolism*
D011228:Prealbumin; D012177:Retinol-Binding Proteins; D054839:Retinol-Binding Proteins, Plasma; D014801:Vitamin A; D014212:Tretinoin