New dammarane-type glycosides from Gynostemma pentaphyllum.
Four novel dammarane glycosides were isolated from a MeOH extract of the aerial parts of Gynostemma pentaphyllum. Their structures were elucidated by 1D and 2D nmr experiments, including 1H-1H correlation spectroscopy (COSY, HOHAHA, NOESY) and 1H-13C heteronuclear correlation (HETCOR). The aglycone moieties are the new dammarane-type triterpenes (20S)-3 beta,20,23 xi-trihydroxydammar-24-en-21-oic acid-21,23-lactone for 1, the corresponding epimer at C-20(20R) for 2, (20S)-dammar-23-ene-3 beta-20,25,26- tetraol for 3, and (20R)-dammar-25-ene-3 beta,20,21,24 xi-tetraol for 4.
Piacente
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Dipartimento di Chimica della Sostanze Naturali, Università degli Studi di Napoli, Federico II, Italy.
Pizza
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De Tommasi
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De Simone
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D002240:Carbohydrate Sequence; D002681:China; D006027:Glycosides / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D018515:Plant Leaves / Q000737:chemistry; D010946:Plants, Medicinal / Q000737:chemistry*; D016339:Spectrometry, Mass, Fast Atom Bombardment; D013237:Stereoisomerism; D014315:Triterpenes / Q000737:chemistry* / Q000302:isolation & purification
D006027:Glycosides; D014315:Triterpenes