[Correlation between tissue blood flow and tissue concentration of 5-FU and its metabolite in hepatic metastasis model for rats].
Correlation between 5-FU (20mg/kg) administrated via the peripheral vein and tissue concentration of its metabolite was studied in hepatic metastasis model prepared for rats. The measurement of tissue samples collected 30 min. after the 5-FU administration suggested a possible negative correlation between the F-dUMP concentration and the blood flow in the normal hepatic tissue of the control group and the tumor tissue in the metastasis group. In administering 5-FU, a time-dependent anticancer drug, to the tumor rich in the tissue blood flow, washing-off effect of the drug by blood outflow cannot be neglected. Some device of prolonging the exposure time of anti-cancer agent to the tumor tissue will be necessary.
Sakai
S
S
Department of Surgery, Teikyo University Hospital, Mizonokuchi.
Yamakawa
T
T
Kano
N
N
Kaminishi
M
M
Oohara
T
T
D000818:Animals; D005472:Fluorouracil / Q000008:administration & dosage / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000098:blood supply* / Q000378:metabolism* / Q000556:secondary; D008297:Male; D051381:Rats
D005472:Fluorouracil