Interaction between intercalation type anticancer drugs and DNA studied by ultraviolet resonance Raman spectroscopy.
The interaction of typical intercalation type anticancer drugs, adriamycin (ADM) and aclacinomycin (ACM), with calf thymus DNA was studied first with ultraviolet resonance Raman spectroscopy (UVRRS). The results demonstrate that the important information such as intercalation sites of drugs, the electronic interaction and the hydrogen bonds between drugs and DNA can be obtained by UVRRS. The method can also show the influence of drugs on DNA conformation and hydrogen bonds between bases of DNA.
Zhao
X
X
State Key Laboratory of Laser Technology, Huazhong University of Science and Technology, Wuhan, China.
Lu
D
D
Jiang
S
S
Mao
C
C
Fan
Y
Y
An
C
C
Li
Z
Z
D015250:Aclarubicin / Q000494:pharmacology*; D000818:Animals; D002417:Cattle; D004247:DNA / Q000737:chemistry / Q000187:drug effects*; D004317:Doxorubicin / Q000494:pharmacology*; D008968:Molecular Conformation; D013059:Spectrum Analysis, Raman / Q000379:methods; D013950:Thymus Gland / Q000737:chemistry; D014466:Ultraviolet Rays
D015250:Aclarubicin; D004317:Doxorubicin; D004247:DNA