Further evidence of a dose-response threshold for haloperidol in psychosis.
OBJECTIVE
The authors' goal was to determine whether higher doses of haloperidol improve antipsychotic response.


METHODS
During a 2-week, double-blind, randomized fixed-dose study, 24 psychotic patients were given 4, 10, or 40 mg/day of haloperidol.


RESULTS
No clinically relevant difference between groups in favor of the higher antipsychotic doses could be detected.


CONCLUSIONS
Doses of 4 mg/day of haloperidol appear to be as effective as higher doses in the treatment of psychosis.
Stone
C K
CK
Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas, USA.
Garve
D L
DL
Griffith
J
J
Hirschowitz
J
J
Bennett
J
J
D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
D006220:Haloperidol