title: Comparative epidemiologic study of premalignant and malignant epithelial cutaneous lesions developing after kidney and heart transplantation.
abstract: BACKGROUND
  Cutaneous carcinomas are the most frequent cancers in organ transplant recipients.
  
  
  OBJECTIVE
  Our purpose was to compare the epidemiologic data of cutaneous premalignant and malignant epithelial lesions in kidney and heart transplant recipients.
  
  
  METHODS
  A total of 580 kidney and 150 heart transplant recipients were examined for the presence of premalignant and malignant epithelial lesions.
  
  
  RESULTS
  A twofold increase in incidence of premalignant and malignant epithelial lesions was found in heart compared with kidney transplant recipients. Heart transplant recipients were older at transplantation, received more intense immunosuppressive treatment, and had a shorter delay from transplantation to the development of the first lesion. The squamous cell carcinoma/basal cell carcinoma ratio was 2.37:1 in kidney and 1.08:1 in heart transplant recipients. The extracephalic location represented 60% of the premalignant and malignant epithelial lesions in kidney and 30% in heart transplant recipients.
  
  
  CONCLUSIONS
  Cutaneous premalignant and malignant epithelial lesions in kidney and heart transplant recipients show epidemiologic differences that can tentatively be explained by the older age and the more intense immunosuppressive treatment of heart transplant recipients.
authors.affiliation: Department of Dermatology, Ed. Herriot Hospital, Lyon, France.
authors.forename: S
authors.initials: S
authors.lastname: Euvrard
authors.forename: J
authors.initials: J
authors.lastname: Kanitakis
authors.forename: C
authors.initials: C
authors.lastname: Pouteil-Noble
authors.forename: G
authors.initials: G
authors.lastname: Dureau
authors.forename: J L
authors.initials: JL
authors.lastname: Touraine
authors.forename: M
authors.initials: M
authors.lastname: Faure
authors.forename: A
authors.initials: A
authors.lastname: Claudy
authors.forename: J
authors.initials: J
authors.lastname: Thivolet
mesh_terms: D000328:Adult; D000367:Age Factors; D001913:Bowen's Disease / Q000453:epidemiology / Q000209:etiology; D002280:Basal Cell Carcinoma / Q000453:epidemiology / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000453:epidemiology / Q000209:etiology; D005260:Female; D016027:Heart Transplantation / Q000009:adverse effects*; D006801:Humans; D007165:Immunosuppression Therapy / Q000009:adverse effects; D015994:Incidence; D007636:Keratoacanthoma / Q000453:epidemiology / Q000209:etiology; D016030:Kidney Transplantation / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D011230:Precancerous Conditions / Q000453:epidemiology* / Q000209:etiology; D012307:Risk Factors; D012878:Skin Neoplasms / Q000453:epidemiology* / Q000209:etiology