title: Urinary excretion of aldosterone, arginine vasopressin and cortisol in premature infants with maximum renal acid stimulation.
abstract: Of 452 low-birth-weight infants who were routinely screened for maximum renal acid stimulation (MRAS) (urine pH < 5.4), 149 episodes of incipient late metabolic acidosis (urine pH < 5.4 on 2 consecutive days) were randomly allocated to either a control group or treatment with NaHCO3 or NaCl (2 mmol/kg/day each) for 7 days. Urinary excretion of aldosterone-18-glucuronide (Aldo), arginine vasopressin (AVP) and cortisol was determined in timed urine samples. On day 1, patients with MRAS showed a tendency towards increased urinary excretion of Aldo compared with infants without MRAS. In patients who received alkali therapy, urinary excretion of Aldo, AVP and cortisol decreased or showed a trend to lower values from day 1 to day 7, whereas in patients with MRAS but no specific therapy, Aldo and AVP showed a tendency to increase. We concluded that persistent MRAS is not only characterized by a reduced rate of weight gain and a tendency to decreased nitrogen assimilation, but also increased secretion of Aldo and AVP.
authors.affiliation: Paediatric Clinic, Dortmund, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Kalhoff
authors.forename: W
authors.initials: W
authors.lastname: Rascher
authors.forename: L
authors.initials: L
authors.lastname: Diekmann
authors.forename: G J
authors.initials: GJ
authors.lastname: Stock
authors.forename: F
authors.initials: F
authors.lastname: Manz
mesh_terms: D000138:Acidosis / Q000188:drug therapy / Q000652:urine*; D000450:Aldosterone / Q000652:urine*; D001127:Arginine Vasopressin / Q000652:urine*; D006801:Humans; D006854:Hydrocortisone / Q000652:urine*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy / Q000652:urine*; D017693:Sodium Bicarbonate / Q000627:therapeutic use*; D012965:Sodium Chloride / Q000627:therapeutic use
chemical_list: D001127:Arginine Vasopressin; D012965:Sodium Chloride; D000450:Aldosterone; D017693:Sodium Bicarbonate; D006854:Hydrocortisone