title: Thyroid antoantibodies and the response to thyrotropin releasing hormone in patients with subclinical hypothyroidism.
abstract: OBJECTIVE
  To evaluate the clinical usefulness of the thyrotropin releasing hormone (TRH) test and estimation of thyroid autoantibody concentrations in patients with borderline raised thyroid stimulating hormone (TSH).
  
  
  METHODS
  The records of 34 consecutive patients with persistent borderline increased TSH (4.4-9.9 mU/l) referred to the Medical Investigation Unit were reviewed. The response of patients with thyroid autoantibodies to the TRH test was compared with that of patients with a negative antibody screen.
  
  
  RESULTS
  Eleven (44%) of 25 patients with positive anti-thyroid microsomal and/or thyroglobulin antibody tests and three (33%) of nine patients with a negative antibody screen had hypothyroid responses to TRH. Neither age nor sex affected the response to TRH. Basal TSH alone was poorly correlated with these indices. Twelve (35%) patients who had elevated basal TSH had a normal response to the TRH test.
  
  
  CONCLUSIONS
  Patients with positive or negative thyroid autoantibodies and an exaggerated response to the TRH test should be regarded as hypothyroid and treated with thyroxine. Patients with positive thyroid autoantibodies and normal TSH response may subsequently develop hypothyroidism and should be given long term follow up.
authors.affiliation: Department of Chemical Pathology and Metabolism, St Helier Hospital, Carshalton, Surrey.
authors.forename: O A
authors.initials: OA
authors.lastname: Mojiminiyi
authors.forename: V
authors.initials: V
authors.lastname: Rege
authors.forename: J
authors.initials: J
authors.lastname: Bolodeoku
authors.forename: A H
authors.initials: AH
authors.lastname: Wilcox
authors.forename: J L
authors.initials: JL
authors.lastname: Barron
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D005260:Female; D006801:Humans; D007037:Hypothyroidism / Q000175:diagnosis* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D013961:Thyroid Gland / Q000276:immunology*; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone
chemical_list: D001323:Autoantibodies; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin