Analgesic effect of Dioclea grandiflora constituents in rodents.
An aqueous fraction and dioclein (5,2',5'-trihydroxy-6,7-dimethoxyflavanone) obtained from the ethanolic extract of the Dioclea grandiflora were tested for their analgesic effect in mice and rats employing acetic-induced writhing and tail flick tests, respectively. When administered intraperitoneally the two agents exhibited significant analgesic effects. The activity of both dioclein and aqueous fraction apparently involves an opiate-like mechanism, since their analgesic action was attenuated by naloxone pretreatment.
Batista
J S
JS
Laboratório de Tecnologia Farmacêutica, Universidade Federal da Paraíba, Brazil.
Almeida
R N
RN
Bhattacharyya
J
J
D000085:Acetates / Q000008:administration & dosage / Q000633:toxicity; D019342:Acetic Acid; D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D000818:Animals; D005591:Chemical Fractionation; D004305:Dose-Response Relationship, Drug; D004347:Drug Interactions; D000431:Ethanol / Q000737:chemistry; D044950:Flavanones; D005419:Flavonoids / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D007274:Injections, Intraperitoneal; D008297:Male; D051379:Mice; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D010146:Pain / Q000188:drug therapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D011897:Random Allocation; D051381:Rats; D017208:Rats, Wistar
D000085:Acetates; D000700:Analgesics; D044950:Flavanones; D005419:Flavonoids; D010936:Plant Extracts; C094747:dioclein; D009270:Naloxone; D000431:Ethanol; D019342:Acetic Acid