title: Three-dimensional functional magnetic resonance imaging of human brain on a clinical 1.5-T scanner.
abstract: Functional magnetic resonance imaging (fMRI) is a tool for mapping brain function that utilizes neuronal activity-induced changes in blood oxygenation. An efficient three-dimensional fMRI method is presented for imaging brain activity on conventional, widely available, 1.5-T scanners, without additional hardware. This approach uses large magnetic susceptibility weighting based on the echo-shifting principle combined with multiple gradient echoes per excitation. Motor stimulation, induced by self-paced finger tapping, reliably produced significant signal increase in the hand region of the contralateral primary motor cortex in every subject tested.
authors.affiliation: National Institutes of Health In Vivo Nuclear Magnetic Resonance Research Center, Biomedical Engineering and Instrumentation Program, Bethesda, MD 20892, USA.
authors.forename: P
authors.initials: P
authors.lastname: van Gelderen
authors.forename: N F
authors.initials: NF
authors.lastname: Ramsey
authors.forename: G
authors.initials: G
authors.lastname: Liu
authors.forename: J H
authors.initials: JH
authors.lastname: Duyn
authors.forename: J A
authors.initials: JA
authors.lastname: Frank
authors.forename: D R
authors.initials: DR
authors.lastname: Weinberger
authors.forename: C T
authors.initials: CT
authors.lastname: Moonen
mesh_terms: D001921:Brain / Q000033:anatomy & histology* / Q000098:blood supply; D005385:Fingers; D006801:Humans; D007091:Image Processing, Computer-Assisted; D008279:Magnetic Resonance Imaging / Q000295:instrumentation* / Q000379:methods; D009043:Motor Activity / Q000502:physiology*; D009044:Motor Cortex / Q000502:physiology*; D010100:Oxygen / Q000097:blood
chemical_list: D010100:Oxygen