title: [Synergism of ciprofloxacin and roxithromycin to Pseudomonas aeruginosa biofilm].
abstract: Synergism of ciprofloxacin (CPFX) and roxithromycin (RXM) to bacterial biofilms formed by Pseudomonas aeruginosa was investigated. Measurement of antibacterial activities and morphological observation with a scanning electron-microscope suggested that RXM eradicated the biofilms by unknown mechanism and thereby enhanced the bactericidal activity of CPFX to P. aeruginosa in biofilms.
authors.affiliation: Department of Microbiology, Kyoto Pharmaceutical University.
authors.forename: N
authors.initials: N
authors.lastname: Gotoh
authors.forename: A
authors.initials: A
authors.lastname: Komoto
authors.forename: T
authors.initials: T
authors.lastname: Nishino
mesh_terms: D018441:Biofilms / Q000187:drug effects*; D002939:Ciprofloxacin / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004357:Drug Synergism; D011550:Pseudomonas aeruginosa; D015575:Roxithromycin / Q000494:pharmacology*
chemical_list: D015575:Roxithromycin; D002939:Ciprofloxacin