title: Clinical trials of immunoadsorbent in systemic lupus erythematosus therapy.
abstract: Five patients with systemic lupus erythematosus (SLE) were perfused through an extracorporeal shunt filled with DNA-immunoadsorbent (DNA immobilized on carbonized resin beads). High concentrations of anti-DNA antibodies (36.4-67.0%) (binding percentage with 125I-DNA) in the serum of SLE patients were reduced to 13.8-53.0%, respectively. The highest removal percentage was 62.1%. Although the decline levels varied, the symptoms of patients, i.e., long-term severe joint pain, severe edema, hydropericardium, and ascites were all relieved considerably. The immunoadsorbent showed satisfactory blood compatibility.
authors.affiliation: Institute for Molecular Biology, Nankai University, Tianjin, China.
authors.forename: C L
authors.initials: CL
authors.lastname: Gao
authors.forename: B A
authors.initials: BA
authors.lastname: Li
authors.forename: C Z
authors.initials: CZ
authors.lastname: Chen
authors.forename: Y T
authors.initials: YT
authors.lastname: Yu
authors.forename: P
authors.initials: P
authors.lastname: Yuan
authors.forename: J C
authors.initials: JC
authors.lastname: Song
mesh_terms: D000974:Antibodies, Antinuclear / Q000097:blood; D006464:Hemoperfusion; D006801:Humans; D007163:Immunosorbent Techniques; D007164:Immunosorbents / Q000627:therapeutic use*; D008180:Lupus Erythematosus, Systemic / Q000097:blood / Q000628:therapy*
chemical_list: D000974:Antibodies, Antinuclear; D007164:Immunosorbents