Insulin and glucagon levels in living related liver transplantation: their interaction with the recovery of graft liver function.
Insulin and glucagon have opposite effects on various hepatic functions, including energy metabolism, which is essential for hepatic viability. To evaluate the effects of insulin and glucagon on the recovery of graft liver function, changes in these levels were investigated in relation to arterial ketone body ration (AKBR) during a 30-h period after graft liver reperfusion in 29 recipients of living related liver transplants. Insulin levels did not change significantly throughout this study, while glucagon levels decreased immediately after reperfusion, indicating a rapid degradation of glucagon by the graft liver. The insulin/glucagon (I/G) ratio increased after reperfusion concomitantly with AKBR. In addition, the I/G ratio was significantly correlated with AKBR after reperfusion. It is concluded that the increase in the I/G ratio was closely related to the recovery of graft liver function as reflected by the AKBR in living related liver transplantation.
Ichimiya
M
M
Second Department of Surgery, Faculty of Medicine, Kyoto University, Japan.
Takada
Y
Y
Shimahara
Y
Y
Jin
M B
MB
Kinoshita
K
K
Takahashi
K
K
Uemoto
S
S
Tanaka
K
K
Ozawa
K
K
Yamaoka
Y
Y
D001786:Blood Glucose / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D005260:Female; D005934:Glucagon / Q000378:metabolism*; D005947:Glucose / Q000378:metabolism; D006085:Graft Survival; D006801:Humans; D007328:Insulin / Q000378:metabolism*; D007659:Ketones / Q000032:analysis; D008099:Liver / Q000378:metabolism* / Q000473:pathology; D016031:Liver Transplantation; D008297:Male
D001786:Blood Glucose; D007328:Insulin; D007659:Ketones; D005934:Glucagon; D005947:Glucose