Insights into the electrophysiology of atrial arrhythmias gained by the catheter ablation experience: "learning while burning, Part II".
Although the development and wide-scale application of catheter ablative techniques has drastically changed the practice of electrophysiology, catheter ablation does not preclude physiologic investigation. On the contrary, given the precise and directed nature of this technique and the increased attention to detailed cardiac mapping that it requires, catheter ablation may be viewed as a tool to provide unique information about arrhythmia substrates. In this article, the insights provided by the catheter ablation experience into the pathophysiology of the focal atrial arrhythmias, atrial tachycardia, sinus node reentrant tachycardia, and inappropriate sinus tachycardia will be reviewed. Atrial arrhythmias were initially difficult to treat with ablative therapy, particularly because they can occur anywhere within the atria and the experience with mapping for surgical ablation was quite limited. A number of novel approaches to atrial mapping have been developed in response to this challenge, and presently, catheter ablation provides effective therapy for the majority of patients with focal atrial arrhythmias. In addition, deliberate attempts at "learning while burning" have already begun to enhance our understanding of the interaction of the structural and electrophysiologic aspects of the substrate for atrial arrhythmias.
Callans
D J
DJ
Philadelphia Heart Institute, Presbyterian Medical Center, PA 19104, USA.
Schwartzman
D
D
Gottlieb
C D
CD
Marchlinski
F E
FE
D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000503:physiopathology*; D001281:Atrial Fibrillation / Q000503:physiopathology; D002036:Bundle of His / Q000502:physiology; D017115:Catheter Ablation / Q000009:adverse effects*; D004562:Electrocardiography; D004594:Electrophysiology; D006801:Humans; D013610:Tachycardia / Q000503:physiopathology; D013611:Tachycardia, Atrioventricular Nodal Reentry / Q000503:physiopathology