Taxol inhibits growth of mesothelioma xenografts.
BACKGROUND
In vitro tests measuring inhibition of adenosine triphosphate activity predicted three mesothelioma xenografts would be sensitive to taxol.


OBJECTIVE
The in vivo therapeutic efficacy of taxol was tested in nude mice carrying the subcutaneous tumors.


METHODS
Once tumor growth reached 100mm3 in size, intraperitoneal taxol, 30 mg/kg, on a day 1, 4, and 8 schedule, was administered to mice bearing subcutaneous mesothelioma xenografts.


RESULTS
Taxol inhibits the growth of all three cell lines. It produces actual tumor regression including some complete responses.


CONCLUSIONS
Taxol is an active drug against mesothelioma. The in vitro cell lines and the in vivo system are useful tools for screening and developing new treatments for mesothelioma.
Lee
J M
JM
Derald H. Ruttenberg Cancer Center, Mount Sinai Medical Center, New York, NY 10029, USA.
Bruckner
H W
HW
Szrajer
L
L
Brenne
U
U
Schindelheim
G
G
Andreotti
P E
PE
D000818:Animals; D002455:Cell Division / Q000187:drug effects*; D002460:Cell Line; D005260:Female; D006801:Humans; D008654:Mesothelioma / Q000188:drug therapy / Q000473:pathology*; D051379:Mice; D008819:Mice, Nude; D017239:Paclitaxel / Q000494:pharmacology* / Q000627:therapeutic use; D013997:Time Factors; D014183:Transplantation, Heterologous; D014407:Tumor Cells, Cultured
D017239:Paclitaxel