title: Racial differences in the association between maternal smoking during pregnancy and lung function in children.
abstract: We recently reported that suburban white schoolchildren whose mothers smoked during pregnancy have significantly reduced lung function. Because inner-city and minority children may be at greater risk for respiratory morbidity, we evaluated the relationship between maternal smoking during pregnancy and lung function in 493 white and 383 black schoolchildren 9 to 11 yr of age in three areas of Philadelphia. The child's passive smoking history was determined from reports by the mother. Spirometry was performed at school. After adjusting for height, weight, age, sex, area of city, race, socioeconomic status, and current exposure to environmental tobacco smoke at home, maternal smoking during pregnancy was associated with significant deficits in FEF25-75 (-8.1%) and FEV1/FVC (-2.0%). The observed deficits were larger for black children than for white children, and they were larger for boys than for girls. These results provide additional evidence of an association between maternal smoking during pregnancy and reduced pulmonary function in children, and they suggest that the association may be modified by race and/or sex.
authors.affiliation: Department of Environmental Health, Harvard School of Public Health, Boston, MA 02115, USA.
authors.forename: J
authors.initials: J
authors.lastname: Cunningham
authors.forename: D W
authors.initials: DW
authors.lastname: Dockery
authors.forename: D R
authors.initials: DR
authors.lastname: Gold
authors.forename: F E
authors.initials: FE
authors.lastname: Speizer
mesh_terms: D044383:Black People; D002648:Child; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008168:Lung / Q000503:physiopathology*; D008297:Male; D008450:Maximal Midexpiratory Flow Rate; D008913:Minority Groups; D015143:Philadelphia; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects; D012307:Risk Factors; D012737:Sex Factors; D012907:Smoking / Q000009:adverse effects*; D013147:Spirometry; D014028:Tobacco Smoke Pollution / Q000009:adverse effects; D014504:Urban Health; D014797:Vital Capacity; D044465:White People; D001741:Black or African American
chemical_list: D014028:Tobacco Smoke Pollution