title: Paediatric experience with acetate-free biofiltration.
abstract: We describe our preliminary experience with five children who received acetate-free biofiltration, a modification of haemodiafiltration without buffer in the dialysate and simultaneous infusion of bicarbonate through a venous port. Adequacy of haemodialysis (HD) was achieved with 3 h treatments three times per week (mean Kt/v 1.35 +/- 0.29, mean protein catabolic rate (PCR) 1.4 +/- 0.3 mg/dl). During the session, pH increased from 7.4 pre HD to 7.5 post HD. The mean bicarbonate infused as a 0.166 M solution averaged 235 +/- 35 mEq/h. Hypertension did not occur. There were no cramps, hypotension or vomiting. Bicarbonate requirements correlated significantly with dialyser surface area and body weight (r = 0.76, P < 0.001).
authors.affiliation: Paediatric Nephrology Unit, Hospital Gregorio Marañon, University of Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Espino Hernandez
authors.forename: D
authors.initials: D
authors.lastname: Morales San Jose
authors.forename: A
authors.initials: A
authors.lastname: Luque de Pablos
mesh_terms: D000293:Adolescent; D001639:Bicarbonates / Q000627:therapeutic use*; D001783:Blood Flow Velocity; D001835:Body Weight; D002648:Child; D005260:Female; D017583:Hemodiafiltration / Q000379:methods*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007262:Infusions, Intravenous; D007676:Kidney Failure, Chronic / Q000378:metabolism / Q000503:physiopathology / Q000628:therapy*; D008297:Male; D011506:Proteins / Q000378:metabolism; D012044:Regression Analysis
chemical_list: D001639:Bicarbonates; D011506:Proteins