[Protective effects of salvianolic acid A against impairment of memory induced by cerebral ischemia-reperfusion in mice].
In the present experiments, an impairment of memory model was made by cerebral ischemia-reperefusion in mice. Sal A at the dosage of 3 and 10 mg.kg-1 i.v. was shown to improve the impairment of memory function induced by cerebral ischemia-reperefusion in step down and step through tests. In these tests, the number of errors of Sal A treated group was less and the latency was longer than that of control group. Meanwhile, Sal A 3 and 10 mg.kg-1 i.v. was found to reduce the MDA contents in the cortex, hippocampus and striatum of cerebral ischemia-reperfused rats in vivo. Sal A 10-100 nmol.L-1 was shown to inhibit the brain lipid-peroxidation and scavenge the free hydroxyl radical in vitro. These results indicate that the antagonistic effects of Sal A on impairment of learning and memory caused by cerebral ischemia-reperefusion may be related with its anti-oxidant activity.
Du
G H
GH
Institute of Materia Medica, Peking Union Medical College.
Zhang
J T
JT
D000818:Animals; D001921:Brain / Q000378:metabolism; D002545:Brain Ischemia / Q000150:complications*; D002109:Caffeic Acids / Q000627:therapeutic use*; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use; D016166:Free Radical Scavengers / Q000494:pharmacology; D007773:Lactates / Q000627:therapeutic use*; D008297:Male; D008569:Memory Disorders / Q000209:etiology / Q000517:prevention & control*; D051379:Mice; D051381:Rats; D015427:Reperfusion Injury / Q000150:complications* / Q000378:metabolism
D002109:Caffeic Acids; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D007773:Lactates; C066201:salvianolic acid A