title: Waldenström's macroglobulinemia with the AML/MDS-associated t(1;3)(p36;q21).
abstract: Two unusual, and perhaps causally related, clinical and cytogenetic features in a patient with Waldenström's macroglobulinemia are presented. Firstly, during the progression of the primary macroglobulinemia bone destruction and hypercalcemia occurred. Secondly, a t(1;3)(p36;q21) was found as the sole clonal chromosomal abnormality. This translocation is characteristic of acute myeloid leukemia (AML) and myelodysplastic syndromes with a high propensity for progressing to AML. The t(1;3) has previously never been reported in a lymphoproliferative disorder. Since the abnormality is associated with acute transformation of cells of the myelopoietic lineages, it is possible that the t(1;3), found in cells of lymphoid origin in the present case, not only induced the neoplastic process as such but also brought about the unusually malignant tumor progression.
authors.affiliation: Department of Clinical Genetics, Lund University Hospital, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Johansson
authors.forename: J
authors.initials: J
authors.lastname: Waldenström
authors.forename: S
authors.initials: S
authors.lastname: Hasselblom
authors.forename: F
authors.initials: F
authors.lastname: Mitelman
mesh_terms: D002878:Chromosomes, Human, Pair 1; D002893:Chromosomes, Human, Pair 3; D005260:Female; D006801:Humans; D006934:Hypercalcemia / Q000209:etiology; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008875:Middle Aged; D009190:Myelodysplastic Syndromes / Q000235:genetics*; D010014:Osteolysis / Q000209:etiology; D014178:Translocation, Genetic; D008258:Waldenstrom Macroglobulinemia / Q000150:complications / Q000235:genetics*