Open flow microperfusion: approach to in vivo glucose monitoring.
A slow flow of liquid over the working tip of a classical glucose needle electrode allows a significant reduction in surface fouling with minimal sample dilution. The fluid flow technique enables relatively drift-free in vivo operation for up to four hours (electrode responses in vitro following explanation of the device after a 4 h monitoring period are within +/- 5% of original values), exhibits a close correlation with blood glucose levels and is unique in requiring no in vivo calibration.
Rigby
G P
GP
University of Manchester, Department of Medicine/Clinical Biochemistry, Salford, UK.
Crump
P
P
Vadgama
P
P
D000818:Animals; D015374:Biosensing Techniques; D001786:Blood Glucose / Q000378:metabolism*; D002138:Calibration; D008991:Monitoring, Physiologic / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley
D001786:Blood Glucose