Role of IL-1 and TNF in the ribomunyl-induced radio-protection.
Ribomunyl, an immunomodulating agent, administered to mice 24 h before irradiation, has a radioprotective effect. Ribomunyl enhances renewal of the hematopoietic tissues damaged by radiation. The results of our work have confirmed that IL-1 and TNF play a significant role in an earlier recovery of hematopoiesis induced by Ribomunyl administration in sublethally irradiated mice. Anti-IL-1 administration before that of Ribomunyl significantly reduced the CFU-GM increase in the bone marrow of mice on day 8 after irradiation with 6 Gy and prevented increase of the neutrophil granulocyte number in the peripheral blood. On the other hand, anti-TNF administration limited the CFU-S increase in the bone marrow and prevented a hematocrit increase in the peripheral blood.
Vávrová
J
J
Military Medical Academy, Department of Radiobiology, Hradec Králové, Czech Republic.
D000276:Adjuvants, Immunologic / Q000494:pharmacology; D000818:Animals; D000906:Antibodies / Q000008:administration & dosage / Q000494:pharmacology*; D000942:Antigens, Bacterial / Q000008:administration & dosage / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D001854:Bone Marrow Cells; D003115:Colony-Stimulating Factors / Q000187:drug effects / Q000528:radiation effects; D005260:Female; D006400:Hematocrit; D007375:Interleukin-1 / Q000276:immunology / Q000502:physiology*; D007958:Leukocyte Count / Q000187:drug effects / Q000528:radiation effects; D051379:Mice; D008811:Mice, Inbred DBA; D009504:Neutrophils / Q000187:drug effects / Q000502:physiology / Q000528:radiation effects; D009929:Organ Size / Q000187:drug effects / Q000276:immunology; D011817:Rabbits; D011829:Radiation Dosage; D011836:Radiation Tolerance / Q000187:drug effects* / Q000502:physiology*; D011837:Radiation-Protective Agents / Q000494:pharmacology; D013154:Spleen / Q000187:drug effects / Q000528:radiation effects; D013997:Time Factors; D014409:Tumor Necrosis Factor-alpha / Q000276:immunology / Q000502:physiology*
D000276:Adjuvants, Immunologic; D000906:Antibodies; D000942:Antigens, Bacterial; D003115:Colony-Stimulating Factors; D007375:Interleukin-1; D011837:Radiation-Protective Agents; C034206:Ribomunyl; D014409:Tumor Necrosis Factor-alpha