Receptors for triglyceride-rich lipoproteins and their role in lipoprotein metabolism.
The triglyceride-rich lipoproteins in normal human plasma are VLDL and chylomicrons and their remnants. Several receptors for these lipoproteins have been described, most of them belonging to the LDL receptor family. The LDL receptor itself is able to recognize remnants through apolipoprotein E. However, the LDL receptor-related protein is the actual candidate to be the chylomicron remnant receptor in the liver and the VLDL receptor might be responsible for VLDL catabolism in muscle and adipose tissue.
Beisiegel
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Medical Clinic, University Hospital Eppendorf, Hamburg, Germany.
D000818:Animals; D001057:Apolipoproteins E / Q000378:metabolism; D006801:Humans; D008049:Lipase / Q000502:physiology; D008074:Lipoproteins / Q000737:chemistry / Q000378:metabolism*; D008079:Lipoproteins, VLDL / Q000378:metabolism; D011509:Proteoglycans / Q000502:physiology; D011973:Receptors, LDL / Q000378:metabolism / Q000502:physiology; D018110:Receptors, Lipoprotein / Q000378:metabolism / Q000502:physiology*; D014280:Triglycerides / Q000032:analysis*
D001057:Apolipoproteins E; D008074:Lipoproteins; D008079:Lipoproteins, VLDL; D011509:Proteoglycans; D011973:Receptors, LDL; D018110:Receptors, Lipoprotein; D014280:Triglycerides; C036053:VLDL receptor; D008049:Lipase