Anticonvulsant effect of intraventricular antiepileptic drugs. Experimental study.
The effect of intraventricular administration of antiepileptic drugs on an experimental model of epileptic seizures in rats has been investigated. Animals were tested in the electroshock test measuring the time duration of the tonic phase of the convulsion. Drugs tested were sodium phenobarbital (200-500-1000 micrograms), phenytoin (50-100-200-500 micrograms), midazolam (100-200-500 micrograms) and sodium valproate (500-1000-2000 micrograms), delivered via a catheter stereotactically placed into the lateral ventricle. Control animals were tested with saline. All antiepileptic drugs showed different degrees of reduction in the duration of the tonic phase before reaching doses that produced neurological symptoms. Our results demonstrate the feasibility to control experimental seizures by means of intraventricular injection of antiepileptic drugs.
González-Darder
J M
JM
Department of Neurosurgery, Faculty of Medicine, University of Cádiz, Spain.
García-Teno
M
M
D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004597:Electroshock; D004827:Epilepsy / Q000188:drug therapy*; D007276:Injections, Intraventricular; D008297:Male; D008874:Midazolam / Q000627:therapeutic use; D010634:Phenobarbital / Q000627:therapeutic use; D010672:Phenytoin / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014635:Valproic Acid / Q000627:therapeutic use
D000927:Anticonvulsants; D014635:Valproic Acid; D010672:Phenytoin; D008874:Midazolam; D010634:Phenobarbital