[Use of a gonadoliberin agonist with or without gonadoliberin pulses for ovulation induction in ovarian dystrophies].
OBJECTIVE
Determine whether ovulation in dystrophic ovaries treated with GnRH agonist followed by GnRH pulses is due to the GnRH pulse or is patient-dependent. SITE. Endocrinology department, CHU Purpan, Toulouse, France.


METHODS
Fifteen infertile patients, age range 22 to 35 years, with ovarian dystrophy were given GnRH agonist (Decapeptyl, 3.75 mg IM on day 3 of the cycle). In 5 patients, an IV pulse of GnRH was then given (6 micrograms/90 min).


METHODS
Mann-Whitney U test, corrected chi 2 test.


RESULTS
Ovulation was achieved in 8/15 cases (3/5 with and 5/10 without pulsatile GnRH p = NS) and 3 pregnancies (without pulsatile GnRH). Before treatment LH was higher in patients who had an ovulation.


CONCLUSIONS
Ovulation can be achieved after GnRH agonist treatment in patients with dystrophic ovaries, with or without pulsatile GnRH, particularly if the initial LH levels are high.
Colombo
P L
PL
Service d'Endocrinologie, CHU Purpan, Toulouse.
Dumoulin
S
S
Saint-Martin
F
F
Caron
P
P
Bennet
A
A
Louvet
J P
JP
D000328:Adult; D004359:Drug Therapy, Combination; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use*; D006801:Humans; D007262:Infusions, Intravenous; D007273:Injections, Intramuscular; D007986:Luteinizing Hormone / Q000097:blood; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000097:blood / Q000188:drug therapy*; D011673:Pulsatile Flow; D016896:Treatment Outcome; D017329:Triptorelin Pamoate / Q000627:therapeutic use*
D017329:Triptorelin Pamoate; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone
Utilisation d'un agoniste de la gonadolibérine suivie ou non de gonadolibérine pulsatile pour l'induction d'ovulation dans les dystrophies ovariennes.