title: Inhibitory effects of quassinoids on Epstein-Barr virus activation.
abstract: Short-term in vitro assays for tumor promoters and anti-tumor promoters (Epstein-Barr virus activation test) were carried out for 45 quassinoids. As a result, some quassinoids showed potent activity, more than 50% inhibition at a molar ratio of 1:1 (TPA/quassinoids). These results led to the following structure-activity relationships: (1) a methyleneoxy bridge and side chain enhance the activity and (2) a sugar moiety reduces the activity.
authors.affiliation: Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Okano
authors.forename: N
authors.initials: N
authors.lastname: Fukamiya
authors.forename: K
authors.initials: K
authors.lastname: Tagahara
authors.forename: H
authors.initials: H
authors.lastname: Tokuda
authors.forename: A
authors.initials: A
authors.lastname: Iwashima
authors.forename: H
authors.initials: H
authors.lastname: Nishino
authors.forename: K H
authors.initials: KH
authors.lastname: Lee
mesh_terms: D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D004854:Herpesvirus 4, Human / Q000254:growth & development*; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014775:Virus Activation / Q000187:drug effects*
chemical_list: D000998:Antiviral Agents; D013755:Tetradecanoylphorbol Acetate