title: Decreased plasma glutathione in cancer of the uterine cervix.
abstract: Plasma total glutathione (GSH) content (reduced plus oxidized) was estimated in varying grades of cervical intraepithelial neoplasia (CIN) and in invasive cervical cancer. The values were compared with age-matched control women. The results show significantly lower level of plasma GSH in CIN III and invasive cancer compared to controls (0.724 versus 1.082 and 0.622 versus 1.082 mumol/ml of plasma, P < 0.05). Further, the odds ratio analysis showed high plasma GSH content was found to be protective against the development of cervical cancer. The results suggest a plausible association of plasma GSH with cervical carcinogenesis. The quantitative changes occurring in plasma total glutathione during cervical carcinogenesis is a useful finding and might represent a systemic biochemical marker for precancerous and cancerous lesions of the uterine cervix.
authors.affiliation: Biochemistry Division, Maulana Azad Medical College, New Delhi, India.
authors.forename: A
authors.initials: A
authors.lastname: Kumar
authors.forename: S
authors.initials: S
authors.lastname: Sharma
authors.forename: C S
authors.initials: CS
authors.lastname: Pundir
authors.forename: A
authors.initials: A
authors.lastname: Sharma
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D002278:Carcinoma in Situ / Q000097:blood* / Q000473:pathology; D016022:Case-Control Studies; D005260:Female; D005978:Glutathione / Q000097:blood*; D006801:Humans; D009367:Neoplasm Staging; D016017:Odds Ratio; D002583:Uterine Cervical Neoplasms / Q000097:blood* / Q000473:pathology
chemical_list: D005978:Glutathione