title: Gene-modified cells for the treatment of cancer.
abstract: Gene therapy involves the insertion of a gene into an organism to treat a disease. Since its early development in the 1970s, gene therapy has expanded rapidly both in terms of the methods available and the number of candidate diseases for treatment. This report reviews gene therapy for cancer, including methodology, pre-clinical studies and experimental clinical trials.
authors.affiliation: Department of Medicine, University of Rochester Medical Center, NY 14642, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Whartenby
authors.forename: G N
authors.initials: GN
authors.lastname: Abraham
authors.forename: P A
authors.initials: PA
authors.lastname: Calabresi
authors.forename: C N
authors.initials: CN
authors.lastname: Abboud
authors.forename: P
authors.initials: P
authors.lastname: Calabresi
authors.forename: A
authors.initials: A
authors.lastname: Marrogi
authors.forename: S M
authors.initials: SM
authors.lastname: Freeman
mesh_terms: D002986:Clinical Trials as Topic; D016207:Cytokines / Q000008:administration & dosage / Q000627:therapeutic use; D016503:Drug Delivery Systems; D015316:Genetic Therapy / Q000639:trends*; D005822:Genetic Vectors; D005854:Germ Cells / Q000473:pathology; D006801:Humans; D007167:Immunotherapy / Q000379:methods; D009369:Neoplasms / Q000235:genetics / Q000628:therapy*; D016376:Oligonucleotides, Antisense / Q000494:pharmacology / Q000627:therapeutic use*
chemical_list: D016207:Cytokines; D016376:Oligonucleotides, Antisense