title: Translocation (5;19)(q13;q13) in a multinodular thyroid goiter.
abstract: We describe the cytogenetics of a multinodular thyroid goiter where 90% of the analyzed cells showed a diploid karyotype with a balanced translocation between chromosomes 5 and 19: 46,XX,t(5;19)(q13;q13). This translocation has been previously described in cases of thyroid adenoma. Our case is the first report of this anomaly in nodular hyperplasia. We discuss its putative role in the neoplastic transformation of thyroid lesions.
authors.affiliation: Service of Genetics, University of La Laguna, Tenerife, Spain.
authors.forename: J C
authors.initials: JC
authors.lastname: Cigudosa
authors.forename: A
authors.initials: A
authors.lastname: Pedrosa Guerra
authors.forename: A
authors.initials: A
authors.lastname: Otero Gómez
authors.forename: J L
authors.initials: JL
authors.lastname: Carrasco Juan
authors.forename: J A
authors.initials: JA
authors.lastname: Pérez Gómez
authors.forename: O F
authors.initials: OF
authors.lastname: Ferrer Roca
authors.forename: J L
authors.initials: JL
authors.lastname: García Miranda
mesh_terms: D000328:Adult; D002869:Chromosome Aberrations / Q000473:pathology*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002888:Chromosomes, Human, Pair 19; D002895:Chromosomes, Human, Pair 5; D006044:Goiter, Nodular / Q000473:pathology*; D006801:Humans; D014178:Translocation, Genetic