title: Cytogenetic findings in a case of nodular fasciitis of the breast.
abstract: We report the cytogenetic findings in a case of nodular fasciitis of the breast. The abnormalities found in all 11 metaphases available for analysis were -2, -2, -13, der(15)t(2;15)(q31;q26), + der(?) t(?;2), + mar1, + mar2. Other consistent abnormalities were also identified. Fluorescence in situ hybridization (FISH) was used to confirm the origin of some of the chromosomes. A large acrocentric chromosome was confirmed to be derived from chromosome 15 with chromosome 2 material translocated onto the q arm. The metacentric der(?)t(?;2) was demonstrated to have part of chromosome 2 on the q arm. No other chromosome 2 material was found. Eight of 11 cells were tetraploid and had two copies of a del(6)(q16q24).
authors.affiliation: Section of Cell Biology and Experimental Pathology, Institute of Cancer Research, Sutton, Surrey, U.K.
authors.forename: S H
authors.initials: SH
authors.lastname: Birdsall
authors.forename: J M
authors.initials: JM
authors.lastname: Shipley
authors.forename: B M
authors.initials: BM
authors.lastname: Summersgill
authors.forename: A J
authors.initials: AJ
authors.lastname: Black
authors.forename: P
authors.initials: P
authors.lastname: Jackson
authors.forename: M W
authors.initials: MW
authors.lastname: Kissin
authors.forename: B A
authors.initials: BA
authors.lastname: Gusterson
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D001941:Breast Diseases / Q000235:genetics*; D002869:Chromosome Aberrations; D005208:Fasciitis / Q000235:genetics*; D006801:Humans; D007621:Karyotyping