Mutations that affect the length, fasciculation, or ventral orientation of specific sensory axons in the Drosophila embryo.
In wild-type Drosophila embryos, five lateral chordotonal (lch) axons in each abdominal hemisegment originate from a midlaterally positioned cluster of neurons and grow, fasciculate, and orient ventrally as they connect with targets in the CNS. We have identified 22 recessive lethal mutations in 12 complementation groups, 8 of which are novel, that differentially affect lch axon growth, fasciculation, or ventral orientation. Mutations in 3 loci result in shorter, but fasciculated and ventrally directed axon bundles. Mutations in 4 complementation groups cause lch axon defasciculation. Mutations in 7 complementation groups cause some lch axon bundles to grow dorsally along a trajectory 180 degrees from normal.
Kolodziej
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Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143-0724, USA.
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D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D048429:Cell Size; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000648:ultrastructure; D005260:Female; D017344:Genes, Insect; D005804:Genes, Lethal; D005808:Genes, Recessive; D005816:Genetic Complementation Test; D005821:Genetic Techniques; D008297:Male; D009024:Morphogenesis / Q000235:genetics; D009154:Mutation; D009475:Neurons, Afferent / Q000648:ultrastructure*