[Comparative quantitative pharmacological-EEG analysis of the effects of psychostimulants].
Amphetamine, caffeine, sydnocarb, meclofenoxate, adapromine, midantan, and nomifensine were studied for their effects on bioelectrical activity and Fourier EEG power spectra of the sensomotor cortex, dorsal hippocamp and lateral hypothalamus of freely behaving awake rats. The drop in the absolute power of all frequency ranges with the enhanced power of fast beta 1,2-ranges was common to the action of psychostimulants. In addition to the common properties, specific features of their action were revealed. Amphetamine, meclofenoxate, and nomifensine were found to increase the amplitude of the dominant peak in the theta-range and amphetamine shifts the frequency of the dominant peak to the region of faster ranges. The agents-induced electrophysiological changes correspond to the varying degrees of activation of the central nervous system, causing the optimization of behavioral functions, abolition of fatigue and drowsiness and enhancing physical and mental working capacity.
Krapivin
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SV
Voronina
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TA
D000662:Amphetamines / Q000494:pharmacology; D000818:Animals; D000928:Antidepressive Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects*; D002110:Caffeine / Q000494:pharmacology; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D004569:Electroencephalography; D008297:Male; D002504:Meclofenoxate / Q000494:pharmacology; D009627:Nomifensine / Q000494:pharmacology; D051381:Rats; D012299:Rimantadine / Q000031:analogs & derivatives / Q000494:pharmacology; D013558:Sydnones / Q000494:pharmacology; D013566:Sympathomimetics / Q000494:pharmacology; D013826:Theta Rhythm / Q000187:drug effects
D000662:Amphetamines; D000928:Antidepressive Agents; D000697:Central Nervous System Stimulants; D013558:Sydnones; D013566:Sympathomimetics; D012299:Rimantadine; D009627:Nomifensine; D002110:Caffeine; C052262:adapromine; D002504:Meclofenoxate; C009257:sidnocarb
Sravnitel'nyĭ kolichestvennyĭ farmako-EEG-analiz deĭstviia psikhostimuliruiushchikh sredstv.