title: Doppler velocimetry and behavioural state development in relation to perinatal outcome in pregnancies complicated by gestational diabetes.
abstract: Seventy-one pregnancies complicated by gestational diabetes and 100 healthy pregnancies were monitored on two occasions (between 27th-32nd and 33rd-36th week of gestation) by behavioural state analysis (1F coincidence; 2F coincidence) and umbilical artery Doppler velocimetry (UA) (Resistance Index, RI). The purpose of our study was to determine if the development of behavioural states and Doppler velocimetry: (1) differ between normal and gestational diabetic cases; (2) in gestational diabetic cases, are they related to the degree of abnormality of the maternal oral glucose tolerance test (OGTT)?; and (3) are they predictors of perinatal outcome? (i.e. emergency caesarean section; low Apgar scores; respiratory distress syndrome; neonatal hypoglycaemia and neurological abnormality in the neonate and/or at 4 months of age). Our findings suggest that: (1) results on behavioral state development and Doppler velocimetry were significantly different in gestational diabetic cases; (2) infants of women with gestational diabetes who are neurologically abnormal during the newborn period, had a poor development of coincidence 2F during fetal life and had neonatal hypoglycaemia more often than infants with a normal neurological outcome; (3) in cases with abnormal neurological outcome, the maternal diabetes was more severe than in those cases with normal outcome.
authors.affiliation: Department of Pediatrics, Giannina Gaslini Children's Hospital, Genoa, Italy.
authors.forename: D
authors.initials: D
authors.lastname: Gazzolo
authors.forename: F
authors.initials: F
authors.lastname: Scopesi
authors.forename: A
authors.initials: A
authors.lastname: Russo
authors.forename: R
authors.initials: R
authors.lastname: Camoriano
authors.forename: F
authors.initials: F
authors.lastname: Santi
authors.forename: G C
authors.initials: GC
authors.lastname: Di Renzo
authors.forename: G H
authors.initials: GH
authors.lastname: Visser
authors.forename: P L
authors.initials: PL
authors.lastname: Bruschettini
mesh_terms: D001519:Behavior; D016640:Diabetes, Gestational / Q000503:physiopathology*; D005260:Female; D005333:Fetus / Q000502:physiology*; D005865:Gestational Age; D006801:Humans; D017078:Laser-Doppler Flowmetry; D009422:Nervous System Diseases / Q000209:etiology; D011247:Pregnancy; D011256:Pregnancy Outcome