[The role of the calcium-accumulating capacity of the intracellular reserves in the smooth muscles of the blood vessels in the development of their catecholamine-related damage].
Noradrenaline (10(-5)M) contractile reactions of smooth muscles of the rabbit arteries and veins (aorta, a. femoralis, V. cava posterior, v. femoralis) were investigated in the calcium-free medium using different methods of loading (0.5 mM Ca2+; 0.5 mM Ca2+; 60 mM K+; 20 mM Ca2+) of their predepleted noradrenaline-sensitive intracellular calcium stores. The comparative analysis of indices of relationships of maximum amplitudes using 0.5 mM Ca2+ in presence of 60 mM K+ and 0.5 mM Ca2+, 20 mM Ca2+ and 0.5 mM Ca2+ has shown that calcium-accumulating ability of vein stores exceeds significantly that in arteries independent of the loading source. The toxic concentration of adrenaline (50 mg/kg in ear vein everyday during 5 days) inhibited more significantly the ability of arterial calcium stores to absorb cytoplasmic but not extracellular calcium. We failed to find the changes of the kind in veins. It has been found that the phenomena described are very important as they show different resistance of arteries and veins to the calcium injury.
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D000818:Animals; D001158:Arteries / Q000187:drug effects / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D002395:Catecholamines / Q000633:toxicity*; D004305:Dose-Response Relationship, Drug; D004837:Epinephrine / Q000633:toxicity; D009119:Muscle Contraction / Q000187:drug effects; D009131:Muscle, Smooth, Vascular / Q000187:drug effects* / Q000378:metabolism*; D009638:Norepinephrine / Q000633:toxicity; D011817:Rabbits; D014680:Veins / Q000187:drug effects / Q000378:metabolism
D002395:Catecholamines; D002118:Calcium; D009638:Norepinephrine; D004837:Epinephrine
Doslidzhennia roli kal'tsiĭakumuliuiuchoï zdatnosti vnutrishn'oklitynnykh zapasnykiv hladen'kykh m'iaziv krovonosnykh sudyn u rozvytku ïkh katekholaminovoho poshkodzhennia.