[The regulation of estradiol and progesterone in tumor necrosis factor production in vitro].
The production of tumor necrosis factor (TNF) induced by lipopolysaccharide (LPS) in peripheral blood mononuclear cells (PBMC) from normal woman were determined. The study investigated the role of regulation of estradiol (E2) and progesterone (P) in the production of TNF in-vitro. The results showed that PBMC would produce TNF when stimulated by E2 or P in culture in-vitro. The appropriate dosages were 125 pmol/L in E2 and 10-20 nmol/L in P. The findings suggested that some sex hormones could play a regulating role in the production of TNF by PBMC. E2 and P may be endogenous substances capable of inducing TNF production. The results revealed a beneficial aspect of sex hormones in anti-cancer treatment.
Lu
S
S
Obstetric and Gynecologic Hospital, Zhejiang Medical University, Hangzhou.
Shi
Y
Y
Yi
H
H
D000328:Adult; D002478:Cells, Cultured; D004958:Estradiol / Q000502:physiology*; D005260:Female; D006801:Humans; D007963:Leukocytes, Mononuclear / Q000166:cytology / Q000378:metabolism*; D010051:Ovarian Neoplasms / Q000378:metabolism; D011374:Progesterone / Q000502:physiology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D014409:Tumor Necrosis Factor-alpha; D011374:Progesterone; D004958:Estradiol