[Calcitriol: role in the regulation of erythropoiesis, use in the treatment of renal anemia].
The efficiency of combined therapy (erythropoietin + calcitriol) used in 8 patients with chronic renal failure on programmed hemodialysis was comparatively evaluated with erythropoietin monotherapy employed in 9 patients with the same disease on hemodialysis which represented a control group. The anti-anemia effect was achieved on the average of 5 weeks earlier in the group of patients given the combined therapy than that in the controls. The differences between the two groups were statistically significant in the rate of anti-anemia effect achievement. Possible mechanisms by which calcitriol enhances the anti-anemia effect of erythropoietin, i.e. the mediated effects and direct action of calcitriol on erythropoiesis, are discussed in the paper.
Nikolaev
A Iu
AIu
Klepikov
P V
PV
Lashutin
S V
SV
Kukhtevich
A V
AV
D000328:Adult; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology*; D002117:Calcitriol / Q000008:administration & dosage / Q000502:physiology* / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004920:Erythropoiesis; D004921:Erythropoietin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013997:Time Factors
D004921:Erythropoietin; D002117:Calcitriol
Kal'tsitriol: rol' v reguliatsii éritropoéza, primenenie v lechenii pochechnoĭ anemii.