title: Uterine rupture in association with alkaloidal ("crack") cocaine abuse.
abstract: The use of alkaloidal ("crack") cocaine in pregnancy can result in systemic and focal vasoconstriction and abnormal uterine contractions forceful enough to cause the complete rupture of a gravid uterus along a previous vertical cesarean section scar. A 43-year-old woman was admitted to the emergency department with acute abdominal pain at 34 weeks' gestation. She had had a low vertical cesarean section 3 years previously for breech presentation with acute fetal distress at 28 weeks' gestation. The patient had a history of heavy "crack" abuse and admitted to inhaling "crack" throughout the day until 4 hours before admission. Within 15 minutes after presentation a laparotomy was performed, revealing an infant floating in the abdominal cavity. A live baby was promptly delivered, and the ruptured uterus was repaired. The patient was discharged 4 days post partum. "Crack" cocaine, through its known effects on the vasculature and contractility of the myometrium, likely facilitated the uterine rupture in this patient. The edges of the rupture wound were surprisingly clean, with little bleeding, perhaps owing to the drug's vasoconstrictive effects. It was therefore feasible to repair the uterus as an alternative approach to hysterectomy.
authors.affiliation: Department of Obstetrics and Gynecology, Bronx-Lebanon Hospital Center, NY 10457, USA.
authors.forename: A
authors.initials: A
authors.lastname: Mishra
authors.forename: B R
authors.initials: BR
authors.lastname: Landzberg
authors.forename: J T
authors.initials: JT
authors.lastname: Parente
mesh_terms: D000328:Adult; D016578:Crack Cocaine; D005260:Female; D006801:Humans; D011247:Pregnancy; D011248:Pregnancy Complications; D019966:Substance-Related Disorders / Q000150:complications*; D014597:Uterine Rupture / Q000209:etiology*
chemical_list: D016578:Crack Cocaine