Late post-operative hypoxaemia and organ dysfunction.
Constant and episodic hypoxaemia are common after major operations in the late post-operative period in the surgical ward. Recent studies have shown that hypoxaemia may be related to the development of myocardial ischaemia and cardiac arrhythmias. Experimental and clinical studies have demonstrated an adverse effect of tissue hypoxia on wound healing and on resistance to bacterial wound infections. Finally, mental confusion and surgical delirium may be related to inadequate arterial oxygenation during the late post-operative period. Late post-operative constant and episodic hypoxaemia may therefore be important surgical risk factors, and further studies on the pathogenesis, prophylaxis and treatment are warranted.
Kehlet
H
H
Department of Surgical Gastroenterology, Hvidovre University Hospital, Denmark.
Rosenberg
J
J
D001145:Arrhythmias, Cardiac / Q000209:etiology; D003072:Cognition Disorders / Q000209:etiology; D006801:Humans; D000860:Hypoxia / Q000209:etiology*; D017202:Myocardial Ischemia / Q000209:etiology; D011183:Postoperative Complications; D013530:Surgical Wound Infection