The human gene encoding the largest subunit of RNA polymerase II.
The nucleotide sequence of a large portion of the human RNA polymerase II large subunit (RpII LS)-encoding gene and its whole gene structure were determined. The RpIILS gene consists of 29 exons. The sequence of the 5' flanking region is highly conserved as compared with that of the mouse RpIILS and contains several SP1-binding sites, a CCAAT sequence and a sequence homologous to a heat-shock element. In addition, several inverted repeats and palindrome sequences were involved in the 5' upstream region. Those suggest that the 5' flanking domain of RpIILS would be highly structured which may be responsible for transcriptional regulation.
Mita
K
K
Division of Biology, National Institute of Radiological Sciences, Chiba, Japan.
Tsuji
H
H
Morimyo
M
M
Takahashi
E
E
Nenoi
M
M
Ichimura
S
S
Yamauchi
M
M
Hongo
E
E
Hayashi
A
A
D000595:Amino Acid Sequence; D001483:Base Sequence; D005091:Exons / Q000235:genetics; D015698:Genomic Library; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D012319:RNA Polymerase II / Q000235:genetics*; D017422:Sequence Analysis, DNA; D013045:Species Specificity
D012319:RNA Polymerase II