title: Control of myocardial reperfusion injury with hypertonic-hyperosmotic solution in isolated rabbit heart.
abstract: The effects of postischemic reperfusion were investigated in 14 isolated rabbit hearts in Langendorff preparation. Seven were controls and the others were reperfused with a sodium 7.5% and dextran 60 (60,000 MW) solution diluted with Krebs-Henseleit buffer to a sodium concentration of 150 mEq/l. The incidence of arrhythmias was lower in this group (p = 0.034). Coronary flow was higher than in controls (p = 0.035), the levels of isoenzyme MB of creatine kinase were lower than in controls (p = 0.035), myocardial water content was also lower (p = 0.047), and histological damage was reduced (p = 0.018). It was concluded that early reperfusion with 7.5% sodium chloride, 6% dextran 60 solution has a protective effect in the treatment of cardiac reperfusion injury.
authors.affiliation: Hospital de Cardiologia, Centro Medico Nacional Siglo, XXI, IMSS, Mexico, D.F., Mexico.
authors.forename: G
authors.initials: G
authors.lastname: Careaga
authors.forename: R
authors.initials: R
authors.lastname: Argüero
authors.forename: A
authors.initials: A
authors.lastname: Chavez-Negrete
authors.forename: G
authors.initials: G
authors.lastname: Valero
authors.forename: E
authors.initials: E
authors.lastname: Portilla
authors.forename: R M
authors.initials: RM
authors.lastname: Garcia
authors.forename: L
authors.initials: L
authors.lastname: Mendoza
authors.forename: L
authors.initials: L
authors.lastname: Angulo
authors.forename: Y
authors.initials: Y
authors.lastname: Miranda
mesh_terms: D000818:Animals; D001145:Arrhythmias, Cardiac / Q000453:epidemiology / Q000209:etiology; D001834:Body Water / Q000378:metabolism; D003326:Coronary Circulation; D003402:Creatine Kinase; D004562:Electrocardiography; D006321:Heart / Q000187:drug effects* / Q000503:physiopathology; D006982:Hypertonic Solutions / Q000494:pharmacology*; D066298:In Vitro Techniques; D015994:Incidence; D007527:Isoenzymes; D015428:Myocardial Reperfusion Injury / Q000150:complications / Q000517:prevention & control*; D009206:Myocardium / Q000378:metabolism / Q000473:pathology; D009994:Osmolar Concentration; D011817:Rabbits
chemical_list: D006982:Hypertonic Solutions; D007527:Isoenzymes; D003402:Creatine Kinase