Growth factor gene expression in tubular epithelial injury.
In animal models of acute renal injury, administration of epidermal, insulin-like or hepatocyte growth factor accelerates restoration of kidney function and normalization of histology, and reduces mortality. Mechanisms for such action include stimulation of anabolism, maintenance of glomerular filtration, and enhancement of tubular regeneration. Further studies are needed to establish the utility of growth factors as therapeutic agents for acute renal failure in humans.
Hammerman
M R
MR
George M. O'Brien Kidney and Urological Disease Center, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri, USA.
Miller
S B
SB
D058186:Acute Kidney Injury / Q000235:genetics / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D004848:Epithelium / Q000473:pathology; D018507:Gene Expression Regulation, Developmental / Q000502:physiology*; D006133:Growth Substances / Q000096:biosynthesis* / Q000235:genetics; D006801:Humans; D007684:Kidney Tubules / Q000378:metabolism* / Q000473:pathology
D006133:Growth Substances