Biclonal acute monoblastic leukemia showing del(7q) and trisomies 9 and 22.
Cytogenetic biclonality is a rare phenomenon in acute myeloid leukemia. We report a case of acute monoblastic leukemia with biclonal cytogenetic abnormalities, showing an abnormal clone with an unusual occurrence of trisomy 9 and trisomy 22, in addition to a second clone with deletion of the long arm of chromosome 7 as the only abnormality. The significance of these findings in leukemogenesis is discussed.
Wong
K F
KF
Department of Pathology, Queen Mary Hospital, Hong Kong.
Kwong
Y L
YL
Tang
K C
KC
D000328:Adult; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002892:Chromosomes, Human, Pair 22; D002897:Chromosomes, Human, Pair 7; D002899:Chromosomes, Human, Pair 9; D002999:Clone Cells; D016044:Fusion Proteins, bcr-abl / Q000235:genetics; D006801:Humans; D016130:Immunophenotyping; D007948:Leukemia, Monocytic, Acute / Q000473:pathology*; D008297:Male; D014314:Trisomy
D016044:Fusion Proteins, bcr-abl