title: Acute pre-tibial myxoedema following radioiodine therapy for thyrotoxic Graves' disease.
abstract: A 54-year-old woman was treated with an oral dose of 555MBq of 131I radioiodine for thyrotoxicosis. She had no clinically detectable extrathyroidal manifestations of Graves' disease at the time, but within two months developed moderately severe ophthalmopathy and very extensive thyroid dermopathy affecting her face, arms, hands and feet, in addition to the classic pre-tibial area. Although she developed mild post radioiodine hypothyroidism, this was detected at an early stage and its treatment had no effect on the extrathyroidal signs. Thyrotrophin receptor antibodies (TRAb) were positive before treatment (22% inhibition of TSH binding in neat serum), rose to very high levels following radioiodine (97.6% inhibition), and fell progressively over the following year during treatment with prednisolone. Thyroglobulin autoantibodies became detectable following radioiodine but thyroid peroxidase antibodies were undetectable throughout. Serum and purified IgG from blood samples obtained prior to steroid therapy and over the subsequent year were tested on a dermal fibroblast cell line in vitro for the stimulation of synthesis of glycosaminoglycans, protein and DNA, but no increase in radiolabel incorporation was apparent for any sample when compared to controls. The temporal relation between the radioiodine and the acute onset of dermopathy and ophthalmopathy, together with the abrupt rise in TRAbs, indicates a probable causal association. However, the absence of in-vitro fibroblast stimulation would suggest that the pathogenesis of Graves' dermopathy is not dependent solely on any simple humoral factor.
authors.affiliation: Department of Medicine and Therapeutics, University of Aberdeen, Aberdeen Royal Infirmary, UK.
authors.forename: R D
authors.initials: RD
authors.lastname: Harvey
authors.forename: R A
authors.initials: RA
authors.lastname: Metcalfe
authors.forename: C
authors.initials: C
authors.lastname: Morteo
authors.forename: W
authors.initials: W
authors.lastname: Furmaniak
authors.forename: A P
authors.initials: AP
authors.lastname: Weetman
authors.forename: J S
authors.initials: JS
authors.lastname: Bevan
mesh_terms: D001323:Autoantibodies / Q000097:blood; D005128:Eye Diseases / Q000209:etiology; D005260:Female; D005347:Fibroblasts / Q000187:drug effects; D006801:Humans; D007074:Immunoglobulin G / Q000494:pharmacology; D007457:Iodine Radioisotopes / Q000009:adverse effects* / Q000627:therapeutic use; D007868:Leg Dermatoses / Q000209:etiology*; D008875:Middle Aged; D009230:Myxedema / Q000209:etiology*; D011989:Receptors, Thyrotropin / Q000276:immunology; D013954:Thyroglobulin / Q000276:immunology; D013971:Thyrotoxicosis / Q000532:radiotherapy*
chemical_list: D001323:Autoantibodies; D007074:Immunoglobulin G; D007457:Iodine Radioisotopes; D011989:Receptors, Thyrotropin; D013954:Thyroglobulin