The influence of heavy metal emissions and Fasciola hepatica infestation on the immunogenicity of a Listeria vaccine.
The effect of oral dosing with emissions containing heavy metals (mercury, lead, copper, cadmium, zinc and chromium) on immune status was tested in 3 groups of sheep. Two groups (Groups I and II) were given emissions for 15 d. One of these groups (Group I) was then also infested with Fasciola hepatica metacercaria on day 16. These 2 groups (Groups I and II) and a control group (Group C) were immunized with a Listeria vaccine on days 8 and 22. A decreased index of metabolic response (IMR) of phagocytes and reduced responses of lymphocytes to mitogenic activation with phytohemagglutinin and L monocytogenes antigen stimulation in the leukocyte migration-inhibition test were recorded. Decreased agglutination titers of serum antibodies against L monocytogenes were observed. The F hepatica infestation had no significant effect on the migration index or IMR.
Pistl
J
J
Department of Microbiology and Immunology, University of Veterinary Medicine, Kosice, Slovak Republic.
Mikula
I
I
Krupicer
I
I
Snirc
J
J
D000284:Administration, Oral; D000818:Animals; D000907:Antibodies, Bacterial / Q000276:immunology; D001428:Bacterial Vaccines / Q000276:immunology*; D004785:Environmental Pollutants / Q000494:pharmacology; D005211:Fascioliasis / Q000276:immunology / Q000662:veterinary*; D007109:Immunity / Q000187:drug effects; D008087:Listeria / Q000276:immunology*; D008670:Metals / Q000494:pharmacology*; D009246:NADH Tetrazolium Reductase / Q000187:drug effects / Q000378:metabolism; D010586:Phagocytes / Q000201:enzymology; D012756:Sheep; D015164:Vaccines, Inactivated / Q000276:immunology
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines; D004785:Environmental Pollutants; D008670:Metals; D015164:Vaccines, Inactivated; D009246:NADH Tetrazolium Reductase