The synergism between bovine papillomavirus type 4 and quercetin is dependent on the timing of exposure.
Exposure to the flavonoid quercetin and transfection with bovine papillomavirus type 4 (BPV-4) DNA lead to oncogenic transformation of primary bovine cells. Here we show that the synergism between quercetin and BPV-4 (or its E7 oncogene) is stronger the shorter the interval between the two treatments. Quercetin immortalizes transformed cells, confers anchorage-independent growth and induces tumorigenicity in cells transfected only with the E7 oncogene.
Cairney
M
M
Beatson Institute for Cancer Research CRC Beatson Laboratories, Glasgow, UK.
Campo
M S
MS
D000818:Animals; D052688:Bovine papillomavirus 1 / Q000235:genetics*; D052697:Bovine papillomavirus 4; D002417:Cattle; D002471:Cell Transformation, Neoplastic; D051379:Mice; D011794:Quercetin / Q000633:toxicity*; D014162:Transfection
D011794:Quercetin