Immunoglobulin idiotypic specificity of AIDS-associated lymphomas and their experimental model.
B cell non-Hodgkin's lymphoma (B-NHL) occurring in immunocompromised hosts, such as acquired immune deficiency syndrome (AIDS) patients, is a high-grade malignancy resistant to regular chemotherapy. To determine whether immunotherapy with public anti-Ig idiotype antibodies can be used to treat these NHL, the Ig idiotype specificity of six NHL in AIDS patients (AIDS-ML) and 23 B-NHL experimentally induced in immunocompromised mice (SCID mice) was investigated. One of the six AIDS-ML and two of the 23 experimental B-NHL reacted monoclonally with a single public antibody, while one AIDS-ML and three experimental B-NHL reacted polyclonally with two or three different antibodies. The presence of Ig idiotypic polyclonality requires special consideration with regard to the introduction of anti-Ig idiotype immunotherapy in these cases.
Cui
L X
LX
Department of Pathology, University of Tokyo, Japan.
Ikenami
M
M
Katano
H
H
Takanashi
M
M
Machinami
R
R
Mori
S
S
D000328:Adult; D000818:Animals; D000888:Antibodies, Anti-Idiotypic / Q000276:immunology*; D002648:Child; D004195:Disease Models, Animal; D005434:Flow Cytometry; D006801:Humans; D007130:Immunoglobulin Idiotypes / Q000032:analysis*; D016483:Lymphoma, AIDS-Related / Q000276:immunology*; D016393:Lymphoma, B-Cell / Q000276:immunology*; D008297:Male; D051379:Mice; D016513:Mice, SCID; D008875:Middle Aged; D009368:Neoplasm Transplantation; D014066:Palatine Tonsil / Q000276:immunology
D000888:Antibodies, Anti-Idiotypic; D007130:Immunoglobulin Idiotypes