title: Genes and behavior as studied through gonadotropin-releasing hormone (GnRH) neurons: comparative and functional aspects.
abstract: 1. GnRH neurons migrate from olfactory placode into the developing basal forebrain in a manner which appears remarkably constant across all vertebrates studied, from fish to human beings. 2. Interruption of this migration can result in Kallmann's Syndrome. Absence of libido by individuals suffering from Kallmann's has allowed us to chart a causal route from a specific gene to a human social behavior.
authors.affiliation: Department of Physiology, Nippon Medical School, Tokyo, Japan.
authors.forename: I
authors.initials: I
authors.lastname: Parhar
authors.forename: D
authors.initials: D
authors.lastname: Pfaff
authors.forename: M
authors.initials: M
authors.lastname: Schwanzel-Fukuda
mesh_terms: D000375:Aging; D000818:Animals; D001921:Brain / Q000502:physiology* / Q000503:physiopathology; D005399:Fishes / Q000254:growth & development; D007987:Gonadotropin-Releasing Hormone / Q000235:genetics / Q000502:physiology*; D006801:Humans; D017436:Kallmann Syndrome / Q000503:physiopathology* / Q000523:psychology*; D009474:Neurons / Q000502:physiology*; D016548:Prosencephalon / Q000502:physiology*; D012919:Social Behavior; D014714:Vertebrates
chemical_list: D007987:Gonadotropin-Releasing Hormone