title: Studies on the inhibitory effects of caffeoylquinic acids on monocyte migration and superoxide ion production.
abstract: Three caffeoylquinic acids, isolated from the Peruvian plants Tessaria integrifolia and Mikania cordifolia that are used medicinally as anti-inflammatory agents, were tested for their activities on monocyte migration and superoxide anion production. 3,5-Di-O-caffeoylquinic and 4,5-di-O-caffeoylquinic acids exhibited an appreciable anti-inflammatory activity in vitro, while the tricaffeoyl derivative was inactive.
authors.affiliation: Istituto di Biochimica delle Proteine ed Enzimologia, Napoli, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Peluso
authors.forename: V
authors.initials: V
authors.lastname: De Feo
authors.forename: F
authors.initials: F
authors.lastname: De Simone
authors.forename: E
authors.initials: E
authors.lastname: Bresciano
authors.forename: M L
authors.initials: ML
authors.lastname: Vuotto
mesh_terms: D000595:Amino Acid Sequence; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D008969:Molecular Sequence Data; D009000:Monocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D010946:Plants, Medicinal / Q000166:cytology; D011801:Quinic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism*
chemical_list: D011801:Quinic Acid; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine