Non-steroidal anti-inflammatory drugs in domestic animals: II Disposition and clinical indications.
Most non-steroidal anti-inflammatory drugs (NSAID's) have similar absorption and disposition characteristics. Absorption after oral administration is good, extensive plasma protein binding results in a small volume of distribution, and excretion of metabolites occurs mainly in the urine after hepatic biotransformation of the active drug. The main clinical indications for use of NSAID's are anti-inflammatory, analgesic and antipyretic, and an increasing list of new indications are continually being found. The disposition, pharmacokinetics and clinical indications of non-steroidal anti-inflammatory drugs in domestic animals are reviewed.
Swan
G E
GE
Department of Pharmacology and Toxicology, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, Republic of South Africa.
Short
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Tubbesing
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UH
D000818:Animals; D000829:Animals, Domestic; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000493:pharmacokinetics* / Q000627:therapeutic use*; D004617:Embolism / Q000188:drug therapy / Q000662:veterinary; D013924:Thrombophlebitis / Q000188:drug therapy / Q000662:veterinary; D013927:Thrombosis / Q000188:drug therapy / Q000662:veterinary
D000894:Anti-Inflammatory Agents, Non-Steroidal