title: Reflex epilepsy of the fowl and its transfer to normal chickens by brain embryonic grafts.
abstract: The genetic photosensitive epilepsy of the Fayoumi chicken was transferred to normal chickens by in situ grafts at 2 days of incubation, of both the prosencephalic and mesencephalic brain vesicles taken from epileptic embryos. However, mesencephalic graft is sufficient to allow convulsions under sound stimulation. Typical EEG patterns are recorded in chimeras having the prosencephalon plus or not the mesencephalon. We conclude that, in this mutant, the whole neural tissue is affected, but the seizure generator is localized inside the mesencephalon, and specific sensory pathways are necessary for seizures to occur.
authors.affiliation: Institut d'Embryologie Cellulaire et Moléculaire, CNRS-UMRC 9924, Nogent/Marne, France.
authors.forename: M A
authors.initials: MA
authors.lastname: Teillet
authors.forename: N
authors.initials: N
authors.lastname: Guy
authors.forename: N
authors.initials: N
authors.lastname: Fadlallah
authors.forename: G
authors.initials: G
authors.lastname: Le Gal La Salle
authors.forename: B
authors.initials: B
authors.lastname: Schuler
authors.forename: C
authors.initials: C
authors.lastname: Batini
authors.forename: N
authors.initials: N
authors.lastname: Le Douarin
authors.forename: R
authors.initials: R
authors.lastname: Naquet
mesh_terms: D000161:Acoustic Stimulation; D000818:Animals; D016380:Brain Tissue Transplantation; D002645:Chickens; D004827:Epilepsy / Q000235:genetics*; D016332:Fetal Tissue Transplantation; D012016:Reference Values; D012018:Reflex / Q000502:physiology*; D014741:Video Recording