title: Chemical modification of tylosin.
abstract: 20-Homo tylosin, 20-nor tylosin, 20-deoxy-19,20-didehydro tylosin (6-vinyl tylosin) and 2",3"-didehydro-3"-deoxy tylosin were prepared by multi-step procedures. 20-Homo tylosin was about twice less active than tylosin while the other compounds exhibited very weak antibacterial activity.
authors.affiliation: Institut de Chimie des Substances Naturelles du C.N.R.S., Gif sur Yvette, France.
authors.forename: S
authors.initials: S
authors.lastname: Bobillot
authors.forename: T
authors.initials: T
authors.lastname: Bakos
authors.forename: P
authors.initials: P
authors.lastname: Sarda
authors.forename: T T
authors.initials: TT
authors.lastname: Thang
authors.forename: L
authors.initials: L
authors.lastname: Ming
authors.forename: A
authors.initials: A
authors.lastname: Olesker
authors.forename: G
authors.initials: G
authors.lastname: Lukacs
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000737:chemistry; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure; D013329:Structure-Activity Relationship; D015645:Tylosin / Q000031:analogs & derivatives / Q000737:chemistry*
chemical_list: D000900:Anti-Bacterial Agents; D015645:Tylosin