Endothelin-1-like immunoreactivity in cerebral cortex of Alzheimer-type dementia.
1. Endothelin-1-like immunoreactivity (ET-1-LI) in cerebral cortex in postmortem brains obtained from patients with Alzheimer-type dementia (ATD) was measured by enzyme-immunoassay. 2. The ET-1-LI in the ATD brains was significantly increased in frontal and occipital cortex than those in the control brains and a significant correlation was found between frontal and temporal lobe of ATD brains. 3. These findings may explain the clinico-radiological results that the cerebral blood flow is decreased in ATD patients, the mechanism of which is still unknown.
Minami
M
M
Department of Psychiatry Juntendo University School of Medicine, Saitama, Japan.
Kimura
M
M
Iwamoto
N
N
Arai
H
H
D000368:Aged; D000544:Alzheimer Disease / Q000175:diagnosis* / Q000276:immunology; D001344:Autopsy; D002540:Cerebral Cortex / Q000737:chemistry* / Q000276:immunology; D016232:Endothelins / Q000032:analysis* / Q000276:immunology*; D005260:Female; D005625:Frontal Lobe / Q000737:chemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D009778:Occipital Lobe / Q000737:chemistry; D010296:Parietal Lobe / Q000737:chemistry; D013702:Temporal Lobe / Q000737:chemistry
D016232:Endothelins