Dual receptor T-cells. Implications for alloreactivity and autoimmunity.
Using monoclonal antibodies to human V alpha, we have estimated that up to one-third of mature T-cells express two V alpha chains as part of two functional and independent T-cell receptors. Cells belonging to this dual TCR subset may be specific for a broader range of antigens than cells with a single receptor. We discuss the possibility that dual receptor T-cells may be involved in alloreactivity and autoimmunity.
Padovan
E
E
Basel Institute for Immunology, Switzerland.
Casorati
G
G
Dellabona
P
P
Giachino
C
C
Lanzavecchia
A
A
D000483:Alleles; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D002454:Cell Differentiation; D006801:Humans; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000737:chemistry* / Q000235:genetics; D013601:T-Lymphocytes / Q000737:chemistry*; D013950:Thymus Gland / Q000166:cytology
D001324:Autoantigens; D016693:Receptors, Antigen, T-Cell, alpha-beta