The upregulation of Na+,K(+)-ATPase pump numbers in lymphocytes from the first-degree unaffected relatives of patients with manic depressive psychosis in response to in vitro lithium and sodium ethacrynate.
Patients with manic depressive disorder (DSM-III-R bipolar disorder) have an abnormality of the Na+,K(+)-ATPase pumps in their lymphocytes: the pump numbers do not upregulate to stimulation with lithium and ethacrynate. We have now investigated the in vitro adaptive responses of lymphocyte Na+,K(+)-ATPase pumps in the first-degree unaffected relatives of patients with a clear history of manic depressive disorder. The lymphocytes of the healthy relatives upregulated their Na+,K(+)-ATPase pumps normally, suggesting that the abnormal response that we have previously observed in patients with the disorder reflects a complex relation between the biochemical phenotype and the development of clinical symptoms.
Antia
I J
IJ
University Department of Clinical Pharmacology, Radcliffe Infirmary, Oxford, UK.
Smith
C E
CE
Wood
A J
AJ
Aronson
J K
JK
D001714:Bipolar Disorder / Q000201:enzymology / Q000235:genetics*; D002478:Cells, Cultured; D004976:Ethacrynic Acid / Q000494:pharmacology*; D006801:Humans; D018021:Lithium Chloride / Q000494:pharmacology*; D008214:Lymphocytes / Q000187:drug effects* / Q000201:enzymology; D000254:Sodium-Potassium-Exchanging ATPase / Q000187:drug effects* / Q000235:genetics; D015854:Up-Regulation / Q000187:drug effects / Q000235:genetics
D000254:Sodium-Potassium-Exchanging ATPase; D018021:Lithium Chloride; D004976:Ethacrynic Acid