title: Neuroblastoma-associated opsoclonus-myoclonus treated with intravenously administered immune globulin G.
abstract: An 18-month-old black girl had progressive truncal ataxia, opsoclonus, and multifocal myoclonus associated with a nonresectable abdominal ganglioneuroblastoma. Before chemotherapy, she received intravenously administered IgG, 1 gm/kg, for 2 days; within 48 hours of the first dose, there was significant improvement of the opsoclonus-myoclonus and ataxia. She required a 1 gm/kg maintenance dose every 4 to 6 weeks for a total of 12 doses, but is now free of symptomatic after 2 years with no therapy.
authors.affiliation: Department of Pediatrics, Children's Hospital of Buffalo, NY 14222, USA.
authors.forename: M J
authors.initials: MJ
authors.lastname: Petruzzi
authors.forename: P A
authors.initials: PA
authors.lastname: de Alarcon
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000150:complications*; D005260:Female; D018305:Ganglioneuroblastoma / Q000150:complications*; D006801:Humans; D016756:Immunoglobulins, Intravenous; D007223:Infant; D009207:Myoclonus / Q000209:etiology / Q000628:therapy*; D015835:Ocular Motility Disorders / Q000209:etiology / Q000628:therapy*; D013997:Time Factors
chemical_list: D016756:Immunoglobulins, Intravenous