Isochromophilones III-VI, inhibitors of acyl-CoA:cholesterol acyltransferase produced by Penicillium multicolor FO-3216.
New azaphilones named isochromophilones III-VI were isolated from the culture broth of Penicillium multicolor FO-3216 as inhibitors of acyl-CoA: cholesterol acyltransferase (ACAT). Their structures were elucidated by NMR and other spectroscopic analyses. The IC50 values of isochromophilones III, IV, V and VI for ACAT activity in an enzyme assay using rat liver microsomes were calculated to be 110, 50, 50 and 120 microM, respectively.
Arai
N
N
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
Shiomi
K
K
Tomoda
H
H
Tabata
N
N
Yang
D J
DJ
Masuma
R
R
Kawakubo
T
T
Omura
S
S
D000818:Animals; D001578:Benzopyrans / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology*; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology; D015394:Molecular Structure; D010407:Penicillium; D051381:Rats; D013237:Stereoisomerism; D002785:Sterol O-Acyltransferase / Q000037:antagonists & inhibitors*; D013329:Structure-Activity Relationship
D001578:Benzopyrans; C095345:isochromophilone III; C095346:isochromophilone IV; C095347:isochromophilone V; C095348:isochromophilone VI; D002785:Sterol O-Acyltransferase