title: Effect of age and radiation on bone healing adjacent to hydroxyapatite placed in the tibia of rats.
abstract: This study investigated the effect of age and radiation on healing after implantation of hydroxyapatite granule in bone. Two groups of 16 male Wistar rats, aged 4 weeks and 2 years were used for this study. Hydroxyapatite particles were placed into the tibia 28 days after the delivery of 15 Gy of irradiation from a Linac source. The results of the present study suggest that an old rat was more vulnerable to the radiation than a young rat. It seemed that age might also be an important factor in the prognosis of the implanted hydroxyapatite in irradiated bone.
authors.affiliation: First Department of Oral and Maxillofacial Surgery, School of Dentistry, Showa University, Tokyo, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shirota
authors.forename: K
authors.initials: K
authors.lastname: Donath
authors.forename: K
authors.initials: K
authors.lastname: Ohno
authors.forename: Y
authors.initials: Y
authors.lastname: Matsui
authors.forename: K
authors.initials: K
authors.lastname: Michi
mesh_terms: D000367:Age Factors; D000818:Animals; D001861:Bone Regeneration / Q000502:physiology* / Q000528:radiation effects*; D017886:Durapatite; D008297:Male; D010012:Osteogenesis / Q000502:physiology / Q000528:radiation effects; D019736:Prostheses and Implants; D051381:Rats; D017208:Rats, Wistar; D013977:Tibia
chemical_list: D017886:Durapatite