title: How safe are the xenogeneic hemostats?--Report of a case of severe systemic allergic reaction.
abstract: We report herein the unusual case of a 55-year-old woman who developed a severe systemic allergy to Avitene (microfibrillar collagen hydrochloride), a xenogeneic agent sometimes used for topical hemostasis in laparoscopic cholecystectomy. The patient developed fever, general fatigue, mild liver dysfunction, and prominent eosinophilia postoperatively. A skin allergy test confirmed that these abnormal findings were attributable to an allergic reaction to Avitene.
authors.affiliation: First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
authors.forename: R
authors.initials: R
authors.lastname: Yasuoka
authors.forename: M
authors.initials: M
authors.lastname: Ohara
authors.forename: M
authors.initials: M
authors.lastname: Shimotsuma
authors.forename: A
authors.initials: A
authors.lastname: Hagiwara
authors.forename: T
authors.initials: T
authors.lastname: Yamane
authors.forename: T
authors.initials: T
authors.lastname: Yamaguchi
authors.forename: T
authors.initials: T
authors.lastname: Takahashi
mesh_terms: D018784:Abdominal Abscess / Q000175:diagnosis; D017081:Cholecystectomy, Laparoscopic; D003094:Collagen / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis; D005260:Female; D006488:Hemostasis, Surgical; D006490:Hemostatics / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis
chemical_list: D006490:Hemostatics; D003094:Collagen