[The injury of heart of rats sustaining delayed fluid resuscitation after burn shock].
Delayed fluid resuscitation of burn shock may lead to many harmful effects. We investigated the injury of heart of burned rats having no fluid resuscitation, immediate and delayed fluid replacement. We used electron spin resonance (ESR) to determine the presence of oxygen free radicals (OFR). We also found significant increase in malondialdehyde (MDA) in delayed resuscitation group. The activity of lactate dehydrogenase isoenzyme (LDH) and creatine phosphokinase isoenzyme (CPK-MB) were increased in the latter group. Immediate fluid replacement can not protect the heart perfectly. Some new measure should be added to the fluid replacement in burn shock.
Lu
W
W
Burn Institute, Changhai Hospiatal.
Chen
Y
Y
Liu
L
L
D000818:Animals; D002056:Burns / Q000150:complications; D003402:Creatine Kinase / Q000378:metabolism; D005440:Fluid Therapy; D005609:Free Radicals; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase / Q000378:metabolism; D008297:Male; D009206:Myocardium / Q000378:metabolism / Q000473:pathology*; D010100:Oxygen / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012774:Shock, Traumatic / Q000378:metabolism* / Q000628:therapy; D013997:Time Factors
D005609:Free Radicals; D007527:Isoenzymes; D007770:L-Lactate Dehydrogenase; D003402:Creatine Kinase; D010100:Oxygen