title: Neonatal alloimmune thrombocytopenia involving HPA-5b (Br(a)): a rare Japanese case.
abstract: Neonatal alloimmune thrombocytopenia (NAIT) is caused by platelet antigen incompatibility between the mother and fetus. The frequency of NAIT varies among ethnic groups. In Caucasians, HPA-5b (Br(a)) is the antigen that is second most frequently implicated. In Japan, NAIT due to anti-HPA-5b antibody is quite rare. The present case is the second case of Br(a)-NAIT in Japanese and the first case serologically confirmed by monoclonal antibody-specific immobilization of platelet antigens.
authors.affiliation: Perinatal Medical Center, Morioka Red Cross Hospital, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Suda
authors.forename: H
authors.initials: H
authors.lastname: Ohto
authors.forename: Y
authors.initials: Y
authors.lastname: Tohyama
authors.forename: S
authors.initials: S
authors.lastname: Morita
authors.forename: A
authors.initials: A
authors.lastname: Ishijima
authors.forename: K
authors.initials: K
authors.lastname: Ishikawa
authors.forename: S
authors.initials: S
authors.lastname: Chida
authors.forename: I
authors.initials: I
authors.lastname: Matsuda
mesh_terms: D016824:Antigens, Human Platelet / Q000276:immunology*; D001327:Autoimmune Diseases / Q000151:congenital* / Q000276:immunology; D005260:Female; D006801:Humans; D007159:Immunologic Tests; D007231:Infant, Newborn; D007564:Japan / Q000453:epidemiology; D008297:Male; D008431:Maternal-Fetal Exchange; D011247:Pregnancy; D013921:Thrombocytopenia / Q000151:congenital* / Q000208:ethnology / Q000276:immunology*
chemical_list: C055973:5b alloantigen, human; D016824:Antigens, Human Platelet