Fetal tissue dosages of retinoids. Experimental study concerning a case of isotretinoin (Roaccutan) administration and pregnancy.
The authors report the case of a women who took retinoids (Roaccutan, isotretinoin) during the first trimester of pregnancy, and a therapeutic abortion was carried out. The interest in this case report lies in the determination of the concentration of isotretinoin and its metabolites (4-oxo-isotretinoin, and tretinoin) in fetal tissues, using high performance liquid chromatography. The findings show the significant transplacental crossing of isotretinoin, an accumulation of 4-oxo-isotretinoin in the liver, and a low concentration of retinoids in the brain of this 4-month-old fetus. The authors emphasize that contraception must be used during retinoid treatment, and 4 weeks after retinoids have been stopped.
Benifla
J L
JL
Department of Obstetrics and Gynecology, A. Béclère Hospital, Clamart, France.
Ville
Y
Y
Imbert
M C
MC
Frydman
R
R
Thomas
A
A
Pons
J C
JC
D000032:Abortion, Therapeutic; D000152:Acne Vulgaris / Q000188:drug therapy; D001921:Brain / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
D015474:Isotretinoin