title: Reanalysis of SCOR and anxiety measures in the Israeli High-Risk Study.
abstract: In an earlier study, skin conductance orienting response (SCOR) and anxiety measures obtained when the subjects of the Israeli High-Risk Study were 11 years old were analyzed, using adult diagnostic information, when the subjects were 26 years old. The present study considers similar data obtained from most of this sample when the subjects were 16 years old. As in the earlier analysis, those subjects who would receive a schizophrenia spectrum diagnosis at 26 had higher anxiety ratings at age 16. Nondiagnosed index subjects also had significantly higher anxiety ratings than the nondiagnosed controls. The subjects who would receive affective spectrum diagnoses at age 26 had the most hyporesponsive SCORs, as predicted, while the subjects who would later be diagnosed in the schizophrenia spectrum had an unexpected hyperresponsive SCOR to the dishabituation tone in a habituation series. Further consideration of the long-term stability of SCORs seems necessary; they may be related to the developing psychopathological processes.
authors.affiliation: Department of Psychology, Hebrew University, Jerusalem, Israel.
authors.forename: S
authors.initials: S
authors.lastname: Kugelmass
authors.forename: N
authors.initials: N
authors.lastname: Faber
authors.forename: L J
authors.initials: LJ
authors.lastname: Ingraham
authors.forename: E
authors.initials: E
authors.lastname: Frenkel
authors.forename: M
authors.initials: M
authors.lastname: Nathan
authors.forename: A F
authors.initials: AF
authors.lastname: Mirsky
authors.forename: G
authors.initials: G
authors.lastname: Ben Shakhar
mesh_terms: D000293:Adolescent; D000328:Adult; D001007:Anxiety / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D001143:Arousal / Q000235:genetics*; D002648:Child; D016241:Child of Impaired Parents / Q000523:psychology*; D015331:Cohort Studies; D005260:Female; D005500:Follow-Up Studies; D005712:Galvanic Skin Response / Q000235:genetics*; D006185:Habituation, Psychophysiologic / Q000235:genetics; D006801:Humans; D007557:Israel; D008297:Male; D010553:Personality Development; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics*; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000235:genetics* / Q000523:psychology; D012931:Social Environment