title: Biological valves beyond fifteen years: the Wessex experience.
abstract: Between 1975 and 1979, 443 biological valves (298 Carpentier-Edwards, 134 homograft, and 11 Hancock valves) were implanted in 415 patients (age, 16 to 77 years; mean, 59 years) with an operative mortality of 2.9%. Total follow-up was 4,248 patient-years. Overall event-free survival was 60% +/- 1.5% (standard deviation) at 10 years and 29% +/- 1.4% at 15 years. Ten-year and 15-year event-free survival were 72% +/- 3.4% and 41% +/- 3.3% for aortic homografts, 62% +/- 3% and 33% +/- 2.8% for isolated aortic xenografts, and 43% +/- 3.5% and 14% +/- 3.0% for isolated mitral xenografts. Freedom from structural valve degeneration was 87% +/- 1.3% and 63% +/- 2.5% for all patients at 10 and 15 years, respectively, 86% +/- 2.7% and 58% +/- 4.1% for aortic homografts, 93% +/- 1.8% and 76% +/- 5.1% for aortic xenografts, and 75% +/- 4.0% and 47% +/- 7.4% for mitral xenografts. Of the 110 remaining patients, echocardiography was performed in 61 patients (23 aortic xenograft, 24 aortic homograft, 9 mitral xenograft, and 5 tricuspid xenograft) between 14 and 17 years after implantation. An early diastolic murmur was heard in 57% of all aortic valve replacements (AVRs) 62.5% of homograft AVRs, and 52% of xenograft AVRs. Echocardiographically, aortic regurgitation was detected in 79%, 83%, and 74% of all AVRs, homografts, and xenografts, respectively. Aortic stenosis was present clinically in 11% of all AVRs, 4% of homograft AVRs, and 17% of xenograft AVRs.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Wessex Cardiothoracic Centre, Southampton General Hospital, United Kingdom.
authors.forename: T J
authors.initials: TJ
authors.lastname: Edwards
authors.forename: S A
authors.initials: SA
authors.lastname: Livesey
authors.forename: I A
authors.initials: IA
authors.lastname: Simpson
authors.forename: J L
authors.initials: JL
authors.lastname: Monro
authors.forename: J K
authors.initials: JK
authors.lastname: Ross
mesh_terms: D000206:Actuarial Analysis; D000293:Adolescent; D000328:Adult; D000368:Aged; D001705:Bioprosthesis; D004452:Echocardiography; D005500:Follow-Up Studies; D006350:Heart Valve Prosthesis; D006801:Humans; D008875:Middle Aged; D011475:Prosthesis Failure