[Effect of bushen shengxue recipe on EPO gene expression of chronic renal insufficiency anemia in rats].
The rats were fed with adenine to establish the chronic renal insufficiency anemia model, and the relationship between renal functional impairment and reticulocytes, hemoglobin and erythropoietin (EPO) synthesis was observed to explore the mechanism of Bushen Shengxue drugs in improving the hemopoietic function. The results showed that the Bushen Shengxue drugs could significantly lower the serum creatinine and blood urea nitrogen of renal insufficiency rats, and through the promotion of EPO gene expression, the animals' anemic status was improved.
Qu
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TCM-WM Basic Theory Dept., Hebei Medical College, Shijiazhuang.
Wen
J K
JK
Li
E
E
D000740:Anemia / Q000188:drug therapy* / Q000378:metabolism; D000818:Animals; D001806:Blood Urea Nitrogen; D003401:Creatine / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D004921:Erythropoietin / Q000235:genetics*; D015870:Gene Expression; D007676:Kidney Failure, Chronic / Q000150:complications*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D004365:Drugs, Chinese Herbal; D004921:Erythropoietin; D003401:Creatine