title: A scheme for the interpretation of primary and secondary disturbances of plasma and urinary amino acid profiles. A possible way to an expert system.
abstract: A general scheme for the interpretation of primary and secondary abnormalities of plasma and urine amino acid concentrations is described. The key steps of this scheme are: analytical assessment of the measurements, comparison of results obtained with the reference values expressed in absolute and/or relative concentrations and identification of abnormally increased ninhydrin-positive compounds. The interpretation of results takes account of the various abnormalities induced by drugs or diet. The origins of these abnormalities are ordered by their frequency. A part of the proposed scheme is now computerized as the first step in the development of an expert system.
authors.affiliation: Laboratoire de Biochimie Médicale B, Hôpital Necker-Enfants Malades, Paris, France.
authors.forename: P
authors.initials: P
authors.lastname: Parvy
authors.forename: J
authors.initials: J
authors.lastname: Bardet
authors.forename: D
authors.initials: D
authors.lastname: Rabier
authors.forename: P
authors.initials: P
authors.lastname: Kamoun
mesh_terms: D000592:Amino Acid Metabolism, Inborn Errors / Q000378:metabolism; D000596:Amino Acids / Q000097:blood* / Q000652:urine*; D002852:Chromatography, Ion Exchange; D005103:Expert Systems; D006801:Humans; D012015:Reference Standards; D012016:Reference Values; D013053:Spectrophotometry
chemical_list: D000596:Amino Acids