title: Patellamide F, A new cytotoxic cyclic peptide from the colonial ascidian Lissoclinum patella.
abstract: Cytotoxicity-directed fractionation of an organic extract of the tunicate Lissoclinum patella afforded a new cyclic octapeptide, patellamide F [1]. The structure and absolute stereochemistry of 1 were established by a combination of spectroscopic and chemical methods. Three known cyclic peptides, patellamide B [2], ulithiacyclamide, and lissoclinamide 3, were also isolated and identified.
authors.affiliation: Laboratory of Drug Discovery Research and Development, National Cancer Institute, Frederick, Maryland 21702-1201, USA.
authors.forename: M A
authors.initials: MA
authors.lastname: Rashid
authors.forename: K R
authors.initials: KR
authors.lastname: Gustafson
authors.forename: J H
authors.initials: JH
authors.lastname: Cardellina
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000302:isolation & purification; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D010126:Ozone / Q000737:chemistry; D010456:Peptides, Cyclic / Q000737:chemistry* / Q000302:isolation & purification; D016339:Spectrometry, Mass, Fast Atom Bombardment; D014407:Tumor Cells, Cultured; D014561:Urochordata / Q000737:chemistry*
chemical_list: D000970:Antineoplastic Agents; D010456:Peptides, Cyclic; C094789:patellamide F; D010126:Ozone