title: Effects of inhalation of steroids on lung permeability in patients with asthma.
abstract: This study evaluated the effect of inhalation of steroids on lung permeability in patients with asthma by measuring the clearance of Tc-99m DTPA aerosol from the alveolar to vascular space. Twenty patients with asthma were studied in the supine position with a gamma camera and the clearance half time (T 1/2) was calculated. The base line lung permeability study was performed before treatment with inhalation of 100 micrograms beclomethasone dipropionate four times daily for 1 week, then the study was repeated. After treatment with inhalation of steroid, there was a change in T 1/2 from 76.4 +/- 37.4 minutes to 86.6 +/- 48.2 minutes (P = 0.08). This preliminary study suggests that lung permeability is not altered by inhaled steroid therapy.
authors.affiliation: Department of Nuclear Medicine, Taichung Veterans General Hospital, Taipei, Taiwan.
authors.forename: S J
authors.initials: SJ
authors.lastname: Wang
authors.forename: C H
authors.initials: CH
authors.lastname: Kao
authors.forename: W Y
authors.initials: WY
authors.lastname: Lin
authors.forename: C Y
authors.initials: CY
authors.lastname: Hsu
authors.forename: C P
authors.initials: CP
authors.lastname: Chang
authors.forename: J L
authors.initials: JL
authors.lastname: Lan
mesh_terms: D000280:Administration, Inhalation; D000293:Adolescent; D000328:Adult; D000336:Aerosols; D000368:Aged; D001249:Asthma / Q000000981:diagnostic imaging / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging / Q000187:drug effects* / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010539:Permeability; D011877:Radionuclide Imaging; D013256:Steroids / Q000008:administration & dosage*; D016284:Technetium Tc 99m Pentetate
chemical_list: D000336:Aerosols; D013256:Steroids; D016284:Technetium Tc 99m Pentetate