title: Phylogenetically distinct hantavirus implicated in a case of hantavirus pulmonary syndrome in the northeastern United States.
abstract: Hantavirus pulmonary syndrome (HPS) is an acute respiratory illness with high mortality. It is caused by a newly described New World hantavirus known as Four Corners virus (FCV). Nearly all cases of HPS have occurred in the western United States. The etiologic agents in those cases have been closely related to each other, based upon comparisons of their genetic sequences. We have molecularly cloned the S genomic segment of a hantavirus (Rl-1) implicated in a case on HPS in the northeastern United States. Nucleotide sequence analysis shows that the Rl-1 virus has many similarities to FCV, but is clearly distinct from the western forms of that virus. These data suggest that HPS can be caused by multiple agents that together form a distinctive evolutionary clade.
authors.affiliation: Department of Pathology, University of New Mexico School of Medicine, University of New Mexico Cancer Research and Treatment Center, Albuquerque, USA.
authors.forename: B
authors.initials: B
authors.lastname: Hjelle
authors.forename: J
authors.initials: J
authors.lastname: Krolikowski
authors.forename: N
authors.initials: N
authors.lastname: Torrez-Martinez
authors.forename: F
authors.initials: F
authors.lastname: Chavez-Giles
authors.forename: C
authors.initials: C
authors.lastname: Vanner
authors.forename: E
authors.initials: E
authors.lastname: Laposata
mesh_terms: D000328:Adult; D000595:Amino Acid Sequence; D000818:Animals; D000914:Antibodies, Viral / Q000276:immunology; D001483:Base Sequence; D003001:Cloning, Molecular; D004279:DNA, Viral / Q000032:analysis; D006476:Orthohantavirus / Q000145:classification* / Q000235:genetics / Q000276:immunology; D018804:Hantavirus Pulmonary Syndrome / Q000276:immunology / Q000821:virology*; D006801:Humans; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D010542:Peromyscus; D010802:Phylogeny; D012237:Rhode Island; D017386:Sequence Homology, Amino Acid
chemical_list: D000914:Antibodies, Viral; D004279:DNA, Viral