title: Proton MR spectroscopy in quantitative in vivo determination of fat content in human liver steatosis.
abstract: To demonstrate that the lipid volume fraction in liver steatosis can be accurately estimated with in vivo hydrogen-1 magnetic resonance (MR) spectroscopy, the authors developed a calibration procedure based on in vitro MR spectroscopy of lipid extracts from steatotic liver specimens. The lipid volume fractions determined with the calibration procedure were compared with the results of histomorphometry and with calibrated computed tomographic (CT) data. The volume fraction of fat determined with MR spectroscopy was in good agreement with the CT results, whereas histomorphometry underestimated the amount of hepatic fat. The results indicate that determination of the fat volume fraction in steatotic liver can be achieved noninvasively with MR spectroscopy.
authors.affiliation: Institute of Radiology, University of Trieste, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Longo
authors.forename: P
authors.initials: P
authors.lastname: Pollesello
authors.forename: C
authors.initials: C
authors.lastname: Ricci
authors.forename: F
authors.initials: F
authors.lastname: Masutti
authors.forename: B J
authors.initials: BJ
authors.lastname: Kvam
authors.forename: L
authors.initials: L
authors.lastname: Bercich
authors.forename: L S
authors.initials: LS
authors.lastname: Crocè
authors.forename: P
authors.initials: P
authors.lastname: Grigolato
authors.forename: S
authors.initials: S
authors.lastname: Paoletti
authors.forename: B
authors.initials: B
authors.lastname: de Bernard
mesh_terms: D000328:Adult; D000368:Aged; D005234:Fatty Liver / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000473:pathology; D005240:Feasibility Studies; D005260:Female; D006801:Humans; D008055:Lipids / Q000032:analysis*; D008099:Liver / Q000737:chemistry* / Q000000981:diagnostic imaging / Q000473:pathology; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D011522:Protons; D012044:Regression Analysis; D014057:Tomography, X-Ray Computed
chemical_list: D008055:Lipids; D011522:Protons