title: Histopathological and histoenzimological investigations of the rheumatoid articular cartilage.
abstract: Twenty seven biopsies of articular cartilage taken intraoperatively from patients with Rheumatoid arthritis (RA) and from control patients with traumas were examined using histopathological techniques (HE, VG, PAS-Alcian, Gömöri, Safranine 0) and histoenzymological techniques (Acid phosphatase-lysomal marker, Chondroitinsulphatase, Peroxidase). Histopathologically, the rheumatoid articular cartilage appears with superficial and deep cartilaginous fissures, frequent perichondrocytic gaps associated with modification of the tinctorial activity. At the pannus synovia-cartilage junction we found invasive and destructive synovial inflammatory infiltrates penetrating and eroding the cartilage. Histoenzymologically, the rheumatoid chondrocytes have a high lysosomal potential (phosphatasic, chondroitinsulphatasic) and highly oxidative potential (peroxidasic) specific for lesion modifications.
authors.affiliation: Victor Babeş Institute.
authors.forename: A
authors.initials: A
authors.lastname: Ciobanu
authors.forename: I R
authors.initials: IR
authors.lastname: Ciobanu
authors.forename: F
authors.initials: F
authors.lastname: Hălălău
authors.forename: D
authors.initials: D
authors.lastname: Laky
authors.forename: I
authors.initials: I
authors.lastname: Dinulescu
authors.forename: D
authors.initials: D
authors.lastname: Stănculescu
authors.forename: M
authors.initials: M
authors.lastname: Stoicescu
authors.forename: I
authors.initials: I
authors.lastname: Stroescu
mesh_terms: D000135:Acid Phosphatase / Q000032:analysis; D001172:Arthritis, Rheumatoid / Q000473:pathology*; D002358:Cartilage, Articular / Q000201:enzymology* / Q000473:pathology*; D002811:Chondroitinsulfatases / Q000032:analysis; D006651:Histocytochemistry; D006801:Humans; D008247:Lysosomes / Q000201:enzymology; D008854:Microscopy, Electron; D009195:Peroxidase / Q000032:analysis
chemical_list: D009195:Peroxidase; D000135:Acid Phosphatase; D002811:Chondroitinsulfatases