[Blood clozapine level and therapeutic adjustment].
We specify first the pharmacokinetic parameters of clozapine and the utilized dosage technique. In forty-four patients, aged 40 (25-66), suffering from schizophrenia developing for 20 years, with 11 years of hospitalisation. Clozapine has been prescribed for at least three months (until 44 months). We base ourselves on the opinion of the clinicians to show that the measurement of the plasma level can improve therapeutic-results. We analyse different situations where the adaptation of the posology is usefully conditioned by clozapinemia, particularly in case of important side effects, of high posology (over 600 mg) and of non response or inadequate response to the treatment.
Préterre
P
P
CHS du Rouvray, Sotteville-les-Rouen.
D000328:Adult; D000368:Aged; D003024:Clozapine / Q000008:administration & dosage / Q000009:adverse effects / Q000493:pharmacokinetics*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D008875:Middle Aged; D011569:Psychiatric Status Rating Scales; D012559:Schizophrenia / Q000097:blood* / Q000188:drug therapy; D012565:Schizophrenic Psychology
D003024:Clozapine
Clozapinémie et ajustement thérapeutique.