title: [An analysis of a disorder in the fibrin-forming phase in virtually healthy middle-aged and elderly subjects by using the ancistron test].
abstract: Damages in the fibrin-formation phase initiated by activation of the blood coagulation system and fibrinolysis and promoted by interaction between fibrinogen and its derivatives (dissolved fibrinogen, products of fibrin and fibrinogen lysis) and by the presence of various blood coagulation inhibitors were found in 34% of practically sound old people and in 47% of people of senile age. It is shown very significant to apply the "ancistrone time" test developed on the basis of enzyme ancistrone-H isolated from the venom of snake Agkistrodon halys halys for estimating the fibrin-formation phase both on the model system and in practically sound people of old and senile age. The ancistrone test permits rapidly (for 30-60s) obtaining qualitative and quantitative characteristic of the fibrinogen level in the blood plasma, of the products of fibrin and fibrinogen lysis, of the blood coagulation inhibitors.
authors.forename: T N
authors.initials: TN
authors.lastname: Platonova
authors.forename: O O
authors.initials: OO
authors.lastname: Sushko
authors.forename: N I
authors.initials: NI
authors.lastname: Lukinova
authors.forename: D A
authors.initials: DA
authors.lastname: Solovĭov
mesh_terms: D000368:Aged; D000465:Algorithms; D003435:Crotalid Venoms; D005337:Fibrin / Q000032:analysis* / Q000096:biosynthesis / Q000187:drug effects*; D005338:Fibrin Fibrinogen Degradation Products / Q000032:analysis / Q000187:drug effects; D005340:Fibrinogen / Q000032:analysis / Q000187:drug effects; D006493:Heparin; D006801:Humans; D008875:Middle Aged; D012016:Reference Values; D012697:Serine Endopeptidases; D013918:Thrombin Time; D013997:Time Factors
chemical_list: D003435:Crotalid Venoms; D005338:Fibrin Fibrinogen Degradation Products; D005337:Fibrin; D005340:Fibrinogen; D006493:Heparin; D012697:Serine Endopeptidases; C063190:ancistron N
vernacular_title: Analiz porushennia fazy fibrynoutvorennia u praktychno zdorovykh osib pokhyloho ta starechoho viku za dopomohoiu antsytronovoho testu.