title: [Which is the optimal pressure level to be obtained with antihypertensive treatment?].
abstract: To what level blood pressure should be brought by antihypertensive treatment is a question with relevant clinical bearing that hypertensiologists have regrettably not yet investigated in a direct way. As a consequence of the lack of direct data on this problem, a dispute has been going on for some time as to whether a decrease in blood pressure below 85 mmHg increases, rather than further decreasing, the coronary risk of the hypertensive patients (the "J-curve" hypothesis). The problem has been finally approached through the design and the initiation of an appropriate large controlled trial, the Hypertension Optimal Treatment (HOT) study.
authors.affiliation: Istituto di Clinica Medica Generale e Terapia Medica, Università degli Studi, Milano.
authors.forename: A
authors.initials: A
authors.lastname: Zanchetti
mesh_terms: D000368:Aged; D000959:Antihypertensive Agents / Q000494:pharmacology / Q000627:therapeutic use*; D001794:Blood Pressure / Q000187:drug effects; D005260:Female; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D008297:Male; D008875:Middle Aged; D016032:Randomized Controlled Trials as Topic
chemical_list: D000959:Antihypertensive Agents
vernacular_title: Qual è il livello di pressione ottimale da raggiungere col trattamento antipertensivo?