title: Pre-injury lidocaine treatment prevents thermal hyperalgesia and cutaneous thermal abnormalities in a rat model of peripheral neuropathy.
abstract: The effect of lidocaine pretreatment on thermal hyperalgesia and thermal skin asymmetries provoked by experimental mononeuropathy was investigated in rats. Forty anesthetized rats were given sciatic nerve ligatures according to the technique of Bennett and Xie. Rats were divided into 3 groups: 16 were ligated without lidocaine, 16 were ligated after lidocaine bathing of the nerve, and 8 were ligated after systemic lidocaine (6-8 mg/kg). Six sham-operated rats for each group were also prepared. From the first postoperative day the responses to the hot-plate test were assessed daily for 4 weeks by tracking the paw-licking latency (PLL) for both hindpaws. Shorter or longer latencies on the operated side were respectively considered sign of hyperalgesia and hypoalgesia. Infrared thermographic images of plantar hindpaws were taken in 22 operated rats in the 2nd postoperative week. Thermographic images of 8 non-operated rats were used as control. Animals operated without lidocaine exhibited shorter PLL (P < 0.001) and a decreased skin temperature on the operated side (P < 0.001). In the lidocaine-pretreated rats, no paw-licking reflex was present for a variable postoperative period (1 week or more) and afterwards there was a trend toward recovery of normal PLL values at the 4th week; the hindpaw skin temperature was symmetrical and normal. Sham-operated rats had normal tests. It is postulated here that lidocaine prevents behavioral and thermal manifestation of mononeuropathy by blocking early afferent injury barrage.
authors.affiliation: Istituto di Neuroscienze e Bioimmagini CNR, Istituto Scientifico H San Raffaele, Milan, Italy Centro di Medicina del Dolore, Istituto Scientifico H San Raffaele, Milan, Italy.
authors.forename: Maria Luisa
authors.initials: ML
authors.lastname: Sotgiu
authors.forename: Anna
authors.initials: A
authors.lastname: Castagna
authors.forename: Marco
authors.initials: M
authors.lastname: Lacerenza
authors.forename: Paolo
authors.initials: P
authors.lastname: Marchettini
mesh_terms: D000818:Animals; D004195:Disease Models, Animal; D006930:Hyperalgesia / Q000517:prevention & control*; D008012:Lidocaine / Q000627:therapeutic use*; D008026:Ligation; D008297:Male; D010523:Peripheral Nervous System Diseases / Q000188:drug therapy*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012584:Sciatic Nerve / Q000293:injuries; D012881:Skin Temperature / Q000187:drug effects*
chemical_list: D008012:Lidocaine