Effects of delta-sleep inducing peptide (DSIP) and some analogues on the activity of monoamine oxidase type A in rat brain under hypoxia stress.
Metabolic effects of delta-sleep inducing peptide (DSIP) under hypoxia stress were investigated in rats subjected to short-term hypoxic conditions (about 0.26 Bar). It was found that DSIP partially restricted stress-induced changes in activity of mitochondrial monoamine oxidase type A (MAO-A) and serotonin level in rat brain. A number of DSIP analogues was tested and among them there were some compounds with enhanced ability to counteract hypoxia induced changes in MAO-A activity and serotonin content in comparison with native neuropeptide.
Khvatova
E M
EM
Nizhnii Novgorod Medical Academy, Russian Federation.
Rubanova
N A
NA
Prudchenko
I A
IA
Mikhaleva
I I
II
D000595:Amino Acid Sequence; D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects*; D003593:Cytoplasm / Q000201:enzymology; D003701:Delta Sleep-Inducing Peptide / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D000860:Hypoxia / Q000201:enzymology*; D008297:Male; D008928:Mitochondria / Q000201:enzymology; D008969:Molecular Sequence Data; D008995:Monoamine Oxidase / Q000378:metabolism*; D051381:Rats; D012701:Serotonin / Q000032:analysis
D012701:Serotonin; D003701:Delta Sleep-Inducing Peptide; D008995:Monoamine Oxidase