[A comparative analysis of the frequency of detecting antibodies to the causative agent of tuberculosis with the incidence of discovering relapses in patients with respiratory organ tuberculosis].
A total of 503 patients with tuberculosis in different phases were tested for antibodies to M.tuberculosis using a complex of serological tests (indirect hemagglutination, passive hemolysis, complement consumption, and enzyme immunoassay). The frequency of exacerbations and recurrences and the incidence of detection of antibodies to M.tuberculosis were analyzed in patients with abating active pulmonary tuberculosis registered in follow-up group II, in patients with clinically cured tuberculosis of the respiratory organs (follow-up group III), and in convalescents with residual changes after cured tuberculosis but at an increased risk of the disease reactivation (follow-up group VII). Tuberculosis was found to recur more frequently in the patients producing antibodies to M.tuberculosis in comparison with those in whom these antibodies were not detected. The author puts forward a hypothesis about a relationship between vegetation of M.tuberculosis in residual foci as a latent tuberculous infection and production of antibodies to this agent. Despite the relative clinical well-being and stability of x-ray data, patients with seropositive diagnosis are at a high risk of developing relapses of tuberculosis of the respiratory organs, this implying that this patient population should be clinically followed up and administered courses of antirelapse therapy.
Evdokimov
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VN
D000328:Adult; D000907:Antibodies, Bacterial / Q000097:blood*; D005260:Female; D006801:Humans; D015994:Incidence; D008168:Lung / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000276:immunology*; D011859:Radiography; D012008:Recurrence; D016036:Seroepidemiologic Studies; D014397:Tuberculosis, Pulmonary / Q000000981:diagnostic imaging / Q000453:epidemiology* / Q000276:immunology*
D000907:Antibodies, Bacterial
Sravnitel'nyĭ analiz chastoty vyiavkeniia antitel k vozbuditeliu tuberkuleza s chastotoĭ obnaruzheniia retsidivov u bol'nykh tuberkulezom organov dykhaniia.