Endogenous histamine induces c-fos expression within paraventricular and supraoptic nuclei.
Thioperamide, an H3-receptor antagonist that enhances endogenous histamine release, induced c-fos mRNA expression and Fos-like immunoreactivity in magnocellular neurones of rat supraoptic and paraventricular nuclei. This response was prevented as a result of blockade of the H1 receptor, indicating that endogenous histamine is able to activate these magnocellular neurones via stimulation of this receptor.
Vizuete
M L
ML
Laboratoire de Physiologie, Faculté de Pharmacie, Université René Descartes, Paris, France.
Dimitriadou
V
V
Traiffort
E
E
Griffon
N
N
Heron
A
A
Schwartz
J C
JC
D000818:Animals; D001483:Base Sequence; D005786:Gene Expression Regulation / Q000187:drug effects / Q000502:physiology*; D016762:Genes, fos / Q000502:physiology*; D006632:Histamine / Q000502:physiology*; D006633:Histamine Antagonists; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008297:Male; D008969:Molecular Sequence Data; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D010286:Paraventricular Hypothalamic Nucleus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D010880:Piperidines / Q000494:pharmacology; D015347:RNA Probes; D012333:RNA, Messenger / Q000096:biosynthesis; D051381:Rats; D017208:Rats, Wistar; D013495:Supraoptic Nucleus / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*
D006633:Histamine Antagonists; D010880:Piperidines; D015347:RNA Probes; D012333:RNA, Messenger; D006632:Histamine; C052075:thioperamide