[Encephalopathy following poisoning with an anticholinergic agent].
A 55-year-old chemical laboratory technician developed mydriasis and ocular hypertension, which lasted for 6 weeks, after synthesizing several kilograms of a scopolamine-related test agent with anticholinergic action and then decanting a powdery intermediary substance, the dust of which he may have inhaled. Six weeks later he suddenly had symptoms of an acute intoxication while synthesizing a scopolamine-related substance. The anticholinergic delirium regressed completely within one day requiring no treatment. But subsequently he developed symptoms of a toxic encephalopathy. This only partially regressed over the following 3 years. Its probable cause is thought to have been either the manifestation of an already existing organic cerebral psychiatric syndrome or an as yet unknown effect of the test substance.
Muttray
A
A
Institut für Arbeits- und Sozialmedizin, Universität Mainz.
Maier
W
W
Vogt
T
T
Demuth
W
W
Konietzko
J
J
D000208:Acute Disease; D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D006801:Humans; D008297:Male; D017056:Medical Laboratory Personnel; D008875:Middle Aged; D009460:Neurologic Examination; D009784:Occupational Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000523:psychology; D010276:Parasympatholytics / Q000506:poisoning*; D011041:Poisoning / Q000150:complications / Q000175:diagnosis / Q000523:psychology; D011208:Powders; D012601:Scopolamine; D013997:Time Factors
D010276:Parasympatholytics; D011208:Powders; D012601:Scopolamine
Enzephalopathie nach Intoxikation mit einem Anticholinergikum.