Serotonin and suicidality: the impact of fluoxetine administration. II: Acute neurobiological effects.
Despite the demonstrated anti-depressant efficacy of the selective serotonin reuptake inhibitors (SSRIs), increased suicidal ideation and/or agitation have been reported in a small proportion of individuals receiving fluoxetine or other SSRIs. Part II of this review examines fluoxetine's acute effects on serotonergic functioning. Although acute fluoxetine administration produces a short-term compensatory decrease in the firing of 5-HT neurons, the neurobiological data reviewed suggests that this decrease probably does not lead to an over-compensatory net decrease in 5-HT functioning. The implications of fluoxetine's complex effects on the 5-HT systems are discussed with respect to clinical practices and future research.
Anderson
G M
GM
Yale Child Study Center, Yale University School of Medicine, New Haven, CT, USA.
Segman
R H
RH
King
R A
RA
D000818:Animals; D001921:Brain / Q000187:drug effects / Q000503:physiopathology; D005473:Fluoxetine / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D011985:Receptors, Serotonin / Q000187:drug effects* / Q000502:physiology; D012307:Risk Factors; D012701:Serotonin / Q000502:physiology*; D013405:Suicide / Q000523:psychology*; D009435:Synaptic Transmission / Q000187:drug effects / Q000502:physiology
D011985:Receptors, Serotonin; D005473:Fluoxetine; D012701:Serotonin