Neoplasms in Proteus syndrome.
We report on 2 children with Proteus syndrome who developed neoplasms. Patient 1 had a probable mesothelioma, although papillary carcinoma of the thyroid could not be completely ruled out. Patient 2 had bilateral ovarian serous cystadenomas with nuclear atypia. Other unusual neoplasms in Proteus syndrome are discussed, together with their etiologic and pathogenetic possibilities.
Gordon
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PL
Division of Genetics, University of Tennessee, Memphis, USA.
Wilroy
R S
RS
Lasater
O E
OE
Cohen
M M
MM
D000328:Adult; D002291:Carcinoma, Papillary / Q000473:pathology; D002648:Child; D002675:Child, Preschool; D018293:Cystadenoma, Serous / Q000473:pathology; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008654:Mesothelioma / Q000473:pathology; D010051:Ovarian Neoplasms / Q000473:pathology; D016715:Proteus Syndrome / Q000473:pathology*; D013964:Thyroid Neoplasms / Q000473:pathology