title: Decreased alveolarization in baboon survivors with bronchopulmonary dysplasia.
abstract: In this study, 12 male baboons were delivered by hysterotomy at 75% of gestation. The development of a nonlethal baboon model permitted a study of lung growth and development in long-term survivors. Control animals were ventilated with clinically appropriate oxygen for the 21 d study period. BPD animals were ventilated with PPV and an FIO2 of 1.0 for 7 d, followed by an FIO2 of 0.8 for 14 d. They survived for 33 wk, at which time a right lower lobe lobectomy was performed. Controls showed normal well-alveolated lungs, whereas BPD lungs showed enlarged airspaces focally, nonclassifiable as alveoli, alveolar ducts, or respiratory bronchioles. Volume densities of alveoli were decreased significantly (p = 0.0009), and enlarged airspaces were significantly increased (p = 0.0003) in the BPD group compared with controls. Alveolar counts verified a significant decrease in alveoli (p = 0.004), and the internal surface area was significantly decreased (p = 0.05) in BPD treated animals compared with controls. These data document that a mild to moderate BPD lesion results in a significant and permanent loss of alveoli and a significant increase in enlarged, unclassifiable airspaces, which together result in a decreased total internal surface area in baboons that survive with their disease.
authors.affiliation: Department of Pathology, University of Texas Health Science Center, San Antonio 78284, USA.
authors.forename: J J
authors.initials: JJ
authors.lastname: Coalson
authors.forename: V
authors.initials: V
authors.lastname: Winter
authors.forename: R A
authors.initials: RA
authors.lastname: deLemos
mesh_terms: D000818:Animals; D001980:Bronchi / Q000254:growth & development / Q000473:pathology; D001997:Bronchopulmonary Dysplasia / Q000473:pathology / Q000503:physiopathology*; D003238:Connective Tissue / Q000473:pathology; D004195:Disease Models, Animal; D005314:Embryonic and Fetal Development; D004848:Epithelium / Q000473:pathology; D005355:Fibrosis; D005865:Gestational Age; D006801:Humans; D007231:Infant, Newborn; D008297:Male; D008854:Microscopy, Electron; D010100:Oxygen / Q000008:administration & dosage; D010215:Papio; D011013:Pneumonectomy; D011650:Pulmonary Alveoli / Q000196:embryology / Q000254:growth & development* / Q000473:pathology; D001261:Pulmonary Atelectasis / Q000473:pathology; D012121:Respiration, Artificial; D017741:Survivors
chemical_list: D010100:Oxygen