Effect of orthotopic transplantation of liver on systemic and splanchnic hemodynamics in conscious rat.
The long-term cardiovascular effects of orthotopic liver transplantation (OLT) were studied in conscious Lewis rats with a radioactive microsphere technique. Three months after OLT with an all-suture technique for graft revascularization (s-OLT), all hemodynamic parameters were similar to control. OLT with "cuffs" fitted to the portal vein and infrahepatic inferior vena cava (c-OLT) led to prominent hemodynamic disturbances including 1) hyperkinetic circulation with increased cardiac index (CI; 22%; P < 0.05) and decreased mean arterial pressure (15%; P < 0.05) and total peripheral resistance (TPR; 28%; P < 0.05); 2) a slight increase in portal pressure (11.8 +/- 0.9 vs. 9.3 +/- 1.7 mmHg in control) and marked portal-systemic shunting (51 +/- 11 vs. 0.05 +/- 0.04% in control; P < 0.05); 3) increased hepatic arterial blood flow (0.49 +/- 0.06 vs. 0.27 +/- 0.04 ml.min-1.g liver wt-1; P < 0.05); 4) splanchnic vasodilation with vascular resistance significantly (P < 0.05) lower in the liver, stomach, and large intestine; and 5) increased blood flow and decreased vascular resistance in the kidneys and heart. Ganglionic blockade with chlorisondamine (5 mg/kg body wt iv) indicated that the increase in CI seen in the c-OLT rats was probably sympathetically mediated, whereas the increase in renal blood flow was a reflection of the increase in CI. After ganglionic blocker administration, TPR and regional vascular resistances decreased to approximately the same extent in the control and c-OLT groups, indicating that vascular sympathetic tone was unchanged in the c-OLT rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Kuznetsova
L V
LV
Department of Visceral and Transplantation Surgery, University of Berne, Inselspital, Switzerland.
Zhao
D
D
Wheatley
A M
AM
D000818:Animals; D002714:Chlorisondamine / Q000494:pharmacology; D005730:Ganglionic Blockers / Q000494:pharmacology; D006439:Hemodynamics; D008102:Liver Circulation; D016031:Liver Transplantation / Q000009:adverse effects / Q000379:methods; D008297:Male; D011169:Portal Vein / Q000601:surgery; D011170:Portasystemic Shunt, Surgical; D051381:Rats; D011917:Rats, Inbred Lew; D013152:Splanchnic Circulation; D013537:Sutures; D014682:Vena Cava, Inferior / Q000601:surgery
D005730:Ganglionic Blockers; D002714:Chlorisondamine