title: Somatostatin receptor expression in the thyroid demonstrated with 111In-octreotide scintigraphy.
abstract: Neuroendocrine tumors with somatostatin receptor expression may be localized by 111In-octreotide scintigraphy. This study examines those thyroid conditions where 111In-octreotide uptake could be observed also in the thyroid gland. 26 consecutive patients who underwent 111In-octreotide scintigraphy for tumor localization were additionally examined for thyroid disease by sonography and 99mTc-pertechnetate scintigraphy. 12 of these patients had no significant thyroid uptake and had an euthyroid normal-sized thyroid gland 14 patients with 111In thyroid uptakes had endemic goiters, two of them with thyroid autonomy and one with Graves' disease. Thus, 111In-octreotide thyroid uptake was predominantly seen in patients with endemic goiter with or without thyroid autonomy.
authors.affiliation: Department of Nuclear Medicine, University of Erlangen-Nuremberg, FRG.
authors.forename: W
authors.initials: W
authors.lastname: Becker
authors.forename: U
authors.initials: U
authors.lastname: Schrell
authors.forename: M
authors.initials: M
authors.lastname: Buchfelder
authors.forename: J
authors.initials: J
authors.lastname: Hensen
authors.forename: J
authors.initials: J
authors.lastname: Wendler
authors.forename: M
authors.initials: M
authors.lastname: Gramatzki
authors.forename: F
authors.initials: F
authors.lastname: Wolf
mesh_terms: D000328:Adult; D015870:Gene Expression; D006043:Goiter, Endemic / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D007205:Indium Radioisotopes; D008297:Male; D015282:Octreotide / Q000031:analogs & derivatives* / Q000378:metabolism; D011877:Radionuclide Imaging; D017481:Receptors, Somatostatin / Q000032:analysis / Q000096:biosynthesis*; D013959:Thyroid Diseases / Q000000981:diagnostic imaging* / Q000378:metabolism; D013961:Thyroid Gland / Q000000981:diagnostic imaging* / Q000378:metabolism; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood; D014463:Ultrasonography
chemical_list: D007205:Indium Radioisotopes; D017481:Receptors, Somatostatin; C094279:indium-111-octreotide; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine; D015282:Octreotide