Inhibitory effects of quassinoids on Epstein-Barr virus activation.
Short-term in vitro assays for tumor promoters and anti-tumor promoters (Epstein-Barr virus activation test) were carried out for 45 quassinoids. As a result, some quassinoids showed potent activity, more than 50% inhibition at a molar ratio of 1:1 (TPA/quassinoids). These results led to the following structure-activity relationships: (1) a methyleneoxy bridge and side chain enhance the activity and (2) a sugar moiety reduces the activity.
Okano
M
M
Department of Interdisciplinary Studies on Natural Environment, Faculty of Integrated Arts and Sciences, Hiroshima University, Japan.
Fukamiya
N
N
Tagahara
K
K
Tokuda
H
H
Iwashima
A
A
Nishino
H
H
Lee
K H
KH
D000998:Antiviral Agents / Q000737:chemistry / Q000494:pharmacology*; D004854:Herpesvirus 4, Human / Q000254:growth & development*; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship; D013755:Tetradecanoylphorbol Acetate / Q000494:pharmacology; D014775:Virus Activation / Q000187:drug effects*
D000998:Antiviral Agents; D013755:Tetradecanoylphorbol Acetate