title: [Clinical observation on diabetic nephropathy treated with alcohol of Abelmoschus manihot].
abstract: Sixty-eight cases of non-insulin dependent diabetes mellitus (NIDDM) complicated with nephropathy were randomly divided into two groups: treated group, 35 cases treated with alcohol extraction of Abelmoschus manihot, Gliclazide and Captopril tablets; control group, 33 cases treated with Gliclazide and Captopril tablets, over a period of 8 weeks. The total effective rate in treated and control group were 83.87% and 31.03%(P < 0.01), urinary micro-albumin were 31.7 mg/L and 76.3 mg/L (P < 0.05), proteinuria were 0.41 g/24h and 0.77 g/24h (P < 0.01), blood beta 2-microglobulin were 3317.8 ng/ml and 3473.1 ng/ml (P < 0.05), urinary beta 2-microglobulin were 367.2 ng/ml and 641.5 ng/ml (P < 0.01), urinary N-acetyl-beta-glucosaminidase (NAG) were 26.3 u/L and 66.7 u/L (P < 0.01), plasma lipid peroxide (LPO) were 6.13 nmol/L and 8.78 nmol/L (P < 0.05), and plasma superoxide anion were 8.36 kcpm and 10.42 kcpm respectively (P < 0.05). It was suggested that Abemoschus manihot alcohol extraction could eliminate oxygen free radicals, alleviate renal tubular-interstitial diseases, improve renal function and reduce proteinuria.
authors.affiliation: Dept. of Renal Disease, Affiliated Hospital of Najing College of TCM.
authors.forename: J Y
authors.initials: JY
authors.lastname: Yu
authors.forename: N N
authors.initials: NN
authors.lastname: Xiong
authors.forename: H F
authors.initials: HF
authors.lastname: Guo
mesh_terms: D000118:Acetylglucosaminidase / Q000652:urine; D000368:Aged; D000419:Albuminuria / Q000652:urine; D002216:Captopril / Q000008:administration & dosage; D003928:Diabetic Nephropathies / Q000188:drug therapy* / Q000378:metabolism; D004359:Drug Therapy, Combination; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage*; D005260:Female; D005907:Gliclazide / Q000008:administration & dosage; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000652:urine; D001613:beta 2-Microglobulin / Q000378:metabolism
chemical_list: D004365:Drugs, Chinese Herbal; D008054:Lipid Peroxides; D001613:beta 2-Microglobulin; D002216:Captopril; D000118:Acetylglucosaminidase; D005907:Gliclazide