Effects of acetylsalicylic acid on serotonin brain receptor subtypes.
1. The lysine salt of acetyl salicylic acid (ASA) at a dose equivalent to 400 mg/kg of acetyl salicylic acid (ASA) was intraperitoneally administered in rats. 2. After 30 and 120 min ASA did not modify the number of receptors nor the affinity of [3H] 8-OH-DPAT binding sites in pons and cerebral cortex. On the other hand, the receptor number in the cortex membranes decreased significantly using [3H] ketanserin as ligand, while the receptor number in the pontine membranes did not change. 3. These data support the involvement of central 5-HT receptors in the mode of action of ASA.
Sandrini
M
M
Department of Biomedical Sciences, University of Modena, Italy.
Vitale
G
G
Dondi
M
M
Pini
L A
LA
D017371:8-Hydroxy-2-(di-n-propylamino)tetralin / Q000493:pharmacokinetics; D000700:Analgesics / Q000494:pharmacology; D000818:Animals; D001241:Aspirin / Q000493:pharmacokinetics / Q000494:pharmacology*; D001923:Brain Chemistry / Q000187:drug effects*; D002540:Cerebral Cortex / Q000187:drug effects / Q000378:metabolism; D007650:Ketanserin / Q000493:pharmacokinetics; D008297:Male; D008566:Membranes / Q000187:drug effects / Q000378:metabolism; D011149:Pons / Q000187:drug effects / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D011985:Receptors, Serotonin / Q000187:drug effects*
D000700:Analgesics; D011985:Receptors, Serotonin; D017371:8-Hydroxy-2-(di-n-propylamino)tetralin; D007650:Ketanserin; D001241:Aspirin