Isochromophilones I and II, novel inhibitors against gp120-CD4 binding produced by Penicillium multicolor FO-2338. II. Structure elucidation.
The structures of isochromophilones I and II, new gp120-CD4 binding inhibitors isolated from a cultured broth of Penicillium multicolor FO-2338, were elucidated by NMR experiments. Both of compounds have an azaphilone skeleton substituted by a chlorine atom at C-5 and a side chain, 3,5-dimethyl-1,3-heptadien at C-3. Additionally, isochromophilone I has a gamma-lactone ring, and isochromophilone II has 2-oxopropyl moiety instead of a gamma-lactone ring.
Matsuzaki
K
K
School of Pharmaceutical Sciences, Kitasato University, Tokyo, Japan.
Tanaka
H
H
Omura
S
S
D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D001578:Benzopyrans / Q000737:chemistry* / Q000494:pharmacology; D015704:CD4 Antigens / Q000378:metabolism; D005663:Furans / Q000737:chemistry* / Q000494:pharmacology; D015699:HIV Envelope Protein gp120 / Q000378:metabolism; D015394:Molecular Structure; D013237:Stereoisomerism; D013329:Structure-Activity Relationship
D000998:Antiviral Agents; D001578:Benzopyrans; D015704:CD4 Antigens; D005663:Furans; D015699:HIV Envelope Protein gp120; C085628:isochromophilone I; C085629:isochromophilone II