title: Multivariate analysis of histopathological features as prognostic factors in patients with papillary thyroid carcinoma.
abstract: A retrospective analysis of 121 papillary thyroid carcinomas was made to assess prognostic factors including histological variants which might be related to survival. The mean follow-up period was 10 years and clinical, surgical and histopathological data were studied. The survival curves were analysed by the Kaplan-Meier method and the multivariate analysis used Cox's regression model. Eighty-seven patients had well differentiated papillary cancers. The survival rate for papillary thyroid cancer was 86 per cent at 5 years and 72 per cent at 10 years. Factors showing prognostic significance for survival were tumour size, extrathyroid extension and histological type. Disease-free survival was influenced by sex, existence of a capsule and nodal metastases. Factors showing a favourable prognosis were: age under 45 years, size less than 4 cm, no extrathyroid extension and well differentiated histological type (P < 0.001). Histological subtype was one of the most important prognostic factors.
authors.affiliation: Department of Surgery, Virgen de la Arrixaca, University Hospital, Murcia, Spain.
authors.forename: A
authors.initials: A
authors.lastname: Moreno-Egea
authors.forename: J M
authors.initials: JM
authors.lastname: Rodriguez-Gonzalez
authors.forename: J
authors.initials: J
authors.lastname: Sola-Perez
authors.forename: T
authors.initials: T
authors.lastname: Soria-Cogollos
authors.forename: P
authors.initials: P
authors.lastname: Parrilla-Paricio
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002291:Carcinoma, Papillary / Q000473:pathology*; D002648:Child; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D011379:Prognosis; D012737:Sex Factors; D015996:Survival Rate; D013964:Thyroid Neoplasms / Q000473:pathology*