title: Functional liver imaging with asialoglycoprotein receptors and serum hyaluronate in a patient with amyloidosis.
abstract: A 47-year-old man with primary amyloidosis was admitted with abdominal pain. A new radionuclide liver imaging technique using Technetium-99m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin, was performed and the serum hyaluronate concentration was measured. Although ordinary laboratory tests revealed only slight abnormalities, the uptake of the radiolabelled ligand for hepatocyte asialo-glycoprotein receptors was decreased, and marked hepatomegaly was revealed. Furthermore, the serum hyaluronate level was elevated. Histological examination of a hepatic needle biopsy specimen revealed a marked deposition of amyloid in the hepatic perisinusoidal spaces. These results indicate that this new radionuclide liver imaging technique (using Technetium-99m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin) and the measurement of serum hyaluronate may be useful supplementary tools for identifying amyloid deposition in the hepatic perisinusoidal spaces in patients with amyloidosis.
authors.affiliation: Social Insurance Kurume Daiichi Hospital, Japan.
authors.forename: O
authors.initials: O
authors.lastname: Hashimoto
authors.forename: M
authors.initials: M
authors.lastname: Harada
authors.forename: M
authors.initials: M
authors.lastname: Sata
authors.forename: K
authors.initials: K
authors.lastname: Imamura
authors.forename: N
authors.initials: N
authors.lastname: Matsukuma
authors.forename: H
authors.initials: H
authors.lastname: Fukushima
authors.forename: S
authors.initials: S
authors.lastname: Itano
authors.forename: M
authors.initials: M
authors.lastname: Ohishi
authors.forename: T
authors.initials: T
authors.lastname: Ueno
authors.forename: A
authors.initials: A
authors.lastname: Iemura
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D001212:Asialoglycoproteins / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008107:Liver Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate
chemical_list: D001212:Asialoglycoproteins; D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D006820:Hyaluronic Acid; D016284:Technetium Tc 99m Pentetate