title: Ventroposterior medial pallidotomy in patients with advanced Parkinson's disease.
abstract: In a preliminary study, the effects of ventroposterior medial pallidotomy were evaluated in five patients with advanced Parkinson's disease in whom medical therapy had failed. The mean age was 67.0 +/- 5.6 years, and the mean Hoehn and Yahr stage when "off" was 3.9 +/- 1.3. Three patients received unilateral pallidotomies; two of these received another pallidotomy after 8 weeks. Two other patients received staged bilateral pallidotomies. No significant differences in overall function could be seen before and after the first surgical procedure. All three patients with peak-dose dyskinesias or dystonia had marked contralateral reduction in these symptoms. Ventroposterior medial pallidotomy can ameliorate peak-dose dyskinesias in patients with advanced Parkinson's disease. Overall function improvement is not remarkable.
authors.affiliation: Department of Neurology, University of Southern California Medical School, Los Angeles, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Sutton
authors.forename: W
authors.initials: W
authors.lastname: Couldwell
authors.forename: M F
authors.initials: MF
authors.lastname: Lew
authors.forename: L
authors.initials: L
authors.lastname: Mallory
authors.forename: S
authors.initials: S
authors.lastname: Grafton
authors.forename: C
authors.initials: C
authors.lastname: DeGiorgio
authors.forename: M
authors.initials: M
authors.lastname: Welsh
authors.forename: M L
authors.initials: ML
authors.lastname: Apuzzo
authors.forename: J
authors.initials: J
authors.lastname: Ahmadi
authors.forename: C H
authors.initials: CH
authors.lastname: Waters
mesh_terms: D000368:Aged; D000978:Antiparkinson Agents / Q000008:administration & dosage / Q000009:adverse effects; D003131:Combined Modality Therapy; D004292:Dominance, Cerebral / Q000502:physiology; D004305:Dose-Response Relationship, Drug; D005260:Female; D005917:Globus Pallidus / Q000503:physiopathology / Q000601:surgery*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D010300:Parkinson Disease / Q000503:physiopathology / Q000601:surgery*; D012086:Reoperation
chemical_list: D000978:Antiparkinson Agents