A subset of striatopallidal neurons are Fos-immunopositive following acute monoamine depletion in the rat.
Experiments were conducted to characterise the Fos-immunopositive neurons that are observed in the dorsal rim of the striatum following monoamine depletion by the systemic administration of reserpine. Using a retrograde tract-tracer, some of these neurons could be shown to project to the globus pallidus but none were seen to project to the entopeduncular nucleus. In addition, these neurons were located in a region of both poor calbindin immunoreactivity and cholinesterase activity. It can be concluded that Fos levels are increased only in a subset of striatopallidal neurons following monoamine depletion. This subset of neurons is located in the dorsal region of the striatum where it has previously been shown that neurons can preferentially be induced to undergo apoptosis upon monoamine depletion.
Cooper
A J
AJ
School of Psychology, University of Birmingham, Edgbaston, UK.
Moser
B
B
Mitchell
I J
IJ
D000818:Animals; D003342:Corpus Striatum / Q000187:drug effects* / Q000276:immunology / Q000378:metabolism; D005917:Globus Pallidus / Q000187:drug effects* / Q000276:immunology; D007150:Immunohistochemistry; D008297:Male; D008996:Monoamine Oxidase Inhibitors; D009474:Neurons / Q000502:physiology; D016760:Proto-Oncogene Proteins c-fos / Q000235:genetics / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012110:Reserpine / Q000494:pharmacology
D008996:Monoamine Oxidase Inhibitors; D016760:Proto-Oncogene Proteins c-fos; D012110:Reserpine