Ototoxicity associated with intravenous bisphosphonate administration.
The development of ototoxicity in association with intravenous pamidronate treatment of Paget's disease is described. The patient developed hearing loss, vertigo, and tinnitus which were exacerbated by subsequent infusions. This potentially serious drug side-effect does not appear to have been reported previously in patients with Paget's disease.
Reid
I R
IR
Department of Medicine, University of Auckland, New Zealand.
Mills
D A
DA
Wattie
D J
DJ
D004164:Diphosphonates / Q000008:administration & dosage / Q000009:adverse effects*; D006311:Hearing Disorders / Q000139:chemically induced*; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D010001:Osteitis Deformans / Q000188:drug therapy*; D000077268:Pamidronate
D004164:Diphosphonates; D000077268:Pamidronate