Comparison of Edmonston-Zagreb, Connaught and Schwarz measles vaccines in Cameroonian infants aged 3-8 months.
Eighty-five Cameroonian infants aged between 3 and 8 months were vaccinated with a high-dose Edmonston-Zagreb (EZ) strain (10(5.6) TDIC50), 81 with a low-dose Connaught strain (10(3) TCID50) and 74 with a medium-dose Schwarz strain (10(4) TCID50). Side-effects were mild (less than 32% of infants) and were not significantly different among the groups, nor were postvaccination anti-measles antibody levels. Postvaccination seropositivity and seroconversion rates were respectively 91.6% and 69% for EZ, 85.3% and 67.7% for Connaught and 75.6% and 62.2% for Schwarz. In the light of concerns regarding high-titre measles vaccines, the overall performance of the Connaught strain warrants its wider evaluation in young infants.
Ndumbe
P M
PM
Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon.
Gilchrist
S A
SA
Pabst
H
H
Sama
M T
MT
Mbede
J
J
D000914:Antibodies, Viral / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008457:Measles / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D008458:Measles Vaccine / Q000009:adverse effects
D000914:Antibodies, Viral; D007074:Immunoglobulin G; D008458:Measles Vaccine