Characterization of a recombinant that locates the hereditary hemochromatosis gene telomeric to HLA-F.
The gene responsible for hereditary hemochromatosis has been shown to be closely linked to the HLA-A and D6S105 loci on the short arm of chromosome 6. Efforts at mapping the disease gene have been hindered, however, by a lack of informative recombinant in this region. We have identified two recombinant individuals in a single affected family and have confirmed recombination by analysis of 16 polymorphic markers located near HLA-A and D6S105. One of the recombinants provides evidence for the location of the hemochromatosis gene telomeric to HLA-F.
Calandro
L M
LM
Division of Public Health Biology and Epidemiology, School of Public, Health University of California, Berkeley 94720-7360, USA.
Baer
D M
DM
Sensabaugh
G F
GF
D000328:Adult; D000368:Aged; D002874:Chromosome Mapping; D002896:Chromosomes, Human, Pair 6 / Q000235:genetics; D005260:Female; D005808:Genes, Recessive / Q000235:genetics; D008040:Genetic Linkage; D005819:Genetic Markers / Q000235:genetics; D006680:HLA Antigens / Q000235:genetics*; D006432:Hemochromatosis / Q000235:genetics*; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree; D011110:Polymorphism, Genetic / Q000235:genetics; D011995:Recombination, Genetic
D005819:Genetic Markers; D006680:HLA Antigens; C062341:HLA-F antigens; D015395:Histocompatibility Antigens Class I