Studies of the influence of ochratoxin A on immune and defense reactions in the mouse model.
In the mouse model, the mycotoxin ochratoxin A has a non-selective suppressive effect on various immune and defence reactions. Apart from weight depression, lymphopenia, neutrophilia and eosinophilia, antibody-producing cells, antibody titres in blood serum and phagocytosis of Escherichia coli by blood phagocytes become suppressed. Moreover, immunized animals show a lower survival rate after experimental infection with Pasteurella multocida as well as an increase in oxygen radicals in blood cells.
Müller
G
G
Federal Institute for Health Protection of Consumers and Veterinary Medicine, Jena, Germany.
Kielstein
P
P
Köhler
H
H
Berndt
A
A
Rosner
H
H
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D007109:Immunity / Q000187:drug effects*; D008214:Lymphocytes / Q000187:drug effects; D051379:Mice; D009793:Ochratoxins / Q000633:toxicity*; D010326:Pasteurella Infections / Q000276:immunology; D010587:Phagocytosis / Q000187:drug effects
D009793:Ochratoxins; C025589:ochratoxin A