title: Presence of immunoreactive pro-opiomelanocortin-derived peptides and cytokines in the thymus of an anuran amphibian (Rana esculenta).
abstract: Pro-opiomelanocortin (POMC)-derived peptide [adrenocorticotropic hormone (ACTH), beta-endorphin, alpha-melanocyte-stimulating hormone (MSH)]- and cytokine (IL-1 alpha, IL-1 beta, IL-2, IL-6, TNF-alpha)-like molecules were demonstrated in PAS positive epithelial cells of the thymus of the anuran amphibian Rana esculenta by an immunocytochemical procedure. Three groups of PAS positive epithelial cells were identified in subcapsular cortex, inner cortex and medulla, respectively. The cells containing ACTH-, alpha-MSH- and cytokine-like molecules were distributed in the cortex and those containing beta-endorphin-like molecules in the medulla and inner cortex. Thymic lymphocytes were always negative for POMC-derived peptides and cytokines. These results suggest that the neuroendocrine function of the thymus can be traced back to lower vertebrates.
authors.affiliation: Department of Animal Biology, University of Modena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Franchini
authors.forename: E
authors.initials: E
authors.lastname: Ottaviani
authors.forename: C
authors.initials: C
authors.lastname: Franceschi
mesh_terms: D000818:Animals; D016207:Cytokines / Q000032:analysis*; D007150:Immunohistochemistry; D011333:Pro-Opiomelanocortin / Q000032:analysis*; D011893:Rana esculenta / Q000378:metabolism*; D013950:Thymus Gland / Q000378:metabolism*
chemical_list: D016207:Cytokines; D011333:Pro-Opiomelanocortin