title: Hepatic failure in a case of multiple myeloma-associated amyloidosis (kappa-AL)
abstract: We report a case of kappa-AL amyloidosis which rapidly developed hepatic failure in a 79-year-old Japanese female who was admitted to our hospital because of abdominal distension and loss of appetite. Laboratory examination revealed a marked deterioration of liver function with cholestasis and monoclonal gammapathy. At the time that the diagnosis of IgG-kappa type multiple myeloma was made, jaundice was advanced, with continuous gastrointestinal bleeding. The patient died of hepatic failure 2 weeks after admission. Needle biopsy of the liver revealed a diffuse, massive deposition of amyloid protein.
authors.affiliation: Second Department of Internal Medicine, Tottori University Faculty of Medicine, Yonago, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Yamamoto
authors.forename: N
authors.initials: N
authors.lastname: Maeda
authors.forename: H
authors.initials: H
authors.lastname: Kawasaki
mesh_terms: D000368:Aged; D000686:Amyloidosis / Q000150:complications* / Q000175:diagnosis / Q000473:pathology*; D001707:Biopsy, Needle; D017809:Fatal Outcome; D005260:Female; D006471:Gastrointestinal Hemorrhage / Q000209:etiology*; D006801:Humans; D008107:Liver Diseases / Q000150:complications / Q000175:diagnosis / Q000473:pathology*; D017093:Liver Failure / Q000209:etiology* / Q000473:pathology; D009101:Multiple Myeloma / Q000150:complications* / Q000175:diagnosis; D014057:Tomography, X-Ray Computed