title: Influence of meal composition on the postprandial response of the pituitary-thyroid axis.
abstract: Ingestion of food can result in an acute decline of serum thyrotropin (TSH) concentrations, but it is not known whether meal composition and/or stomach distension are influential. Normal men and women were given a normocaloric or hypocaloric, isobulk meal at lunch and at dinner in a randomized design. The normocaloric, but not the isobulk, meal resulted in a significant decline in serum TSH at both lunch and dinner; thyroid hormones and cortisol were not affected significantly. These findings suggest that meal composition is influential in the acute postprandial decline of serum TSH in man. A possible mechanism is food-induced elevation of somatostatin and consequent suppression of TSH secretion.
authors.affiliation: Neurosciences Research Center, Medical College of Pennsylvania, Pittsburgh, USA.
authors.forename: V
authors.initials: V
authors.lastname: Kamat
authors.forename: W L
authors.initials: WL
authors.lastname: Hecht
authors.forename: R T
authors.initials: RT
authors.lastname: Rubin
mesh_terms: D000328:Adult; D004435:Eating / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology*; D005260:Female; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D008875:Middle Aged; D010902:Pituitary Gland / Q000502:physiology*; D012727:Sex Characteristics; D013961:Thyroid Gland / Q000502:physiology*; D013963:Thyroid Hormones / Q000097:blood; D013972:Thyrotropin / Q000097:blood
chemical_list: D013963:Thyroid Hormones; D013972:Thyrotropin; D006854:Hydrocortisone