title: Nuclear hormone receptors activate direct, inverted, and everted repeats.
abstract: Nuclear hormone receptors comprise a family of ligand-modulated transcription factors that link cellular responses to extracellular and intracellular signals. Receptors for retinoids, thyroid hormone, vitamin D3 and fatty acids/peroxisome proliferators bind their response elements as heterodimers with the retinoid X receptor. Naturally occurring response elements are composed of core-motifs that are organized as direct, inverted, and/or everted repeats. The structural mechanisms that facilitate binding of a single receptor heterodimer to such diverse binding sites remain unknown.
authors.affiliation: Howard Hughes Medical Institute, San Diego, California 92037-5800, USA.
authors.forename: B M
authors.initials: BM
authors.lastname: Forman
authors.forename: R M
authors.initials: RM
authors.lastname: Evans
mesh_terms: D000818:Animals; D001483:Base Sequence; D001665:Binding Sites; D002467:Cell Nucleus / Q000378:metabolism; D004247:DNA / Q000235:genetics* / Q000378:metabolism*; D006801:Humans; D011487:Protein Conformation; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism*; D012091:Repetitive Sequences, Nucleic Acid; D015533:Transcriptional Activation
chemical_list: D011956:Receptors, Cell Surface; D004247:DNA