NF-kappa B activation by interleukin-1 (IL-1) requires an IL-1 receptor-associated protein kinase activity.
An important function of interleukin-1 (IL-1) is activation of the transcription factor NF-kappa B, which is signaled via the type I IL-1 receptor (IL-1RI). By receptor mutagenesis studies, we have identified a region of the cytoplasmic domain of IL-1RI that is required for both IL-1-mediated NF-kappa B activation and IL-1-dependent activation of a receptor-associated protein kinase activity we term IRAK. No IL-1RI mutants were found that can activate NF-kappa B in the absence of IRAK activity. Therefore, we propose that IRAK activation is a necessary step in the activation of NF-kappa B by IL-1.
Croston
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GE
Tularik, Inc., South San Francisco, California 94080, USA.
Cao
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Goeddel
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DV
D002478:Cells, Cultured; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D016328:NF-kappa B / Q000378:metabolism*; D011494:Protein Kinases / Q000502:physiology*; D017472:Receptors, Interleukin-1 / Q000502:physiology*
D007375:Interleukin-1; D016328:NF-kappa B; D017472:Receptors, Interleukin-1; D011494:Protein Kinases