title: A randomized prospective comparison between intrauterine insemination and fallopian sperm perfusion for the treatment of infertility.
abstract: OBJECTIVE
  To determine if the pregnancy rates (PRs) in infertile women could be improved with fallopian sperm perfusion in comparison with IUI.
  
  
  METHODS
  Randomized prospective analysis.
  
  
  METHODS
  Academically affiliated infertility center.
  
  
  METHODS
  Consecutive patients undergoing controlled ovarian hyperstimulation (COH).
  
  
  METHODS
  After hCG administration, patients were randomized to either IUI or fallopian sperm perfusion.
  
  
  METHODS
  Pregnancy rates with the two treatment modalities.
  
  
  RESULTS
  Of 240 COH cycles, those randomized to IUI included 44 clomiphene citrate (CC) (group I) and 76 gonadotropin (group III) cycles. Patients receiving fallopian sperm perfusion included 44 cycles of CC (group II) and 76 cycles of gonadotropin (group IV) treatment. The overall PRs per cycle (10.8% versus 10.8%) were similar for IUI and fallopian sperm perfusion, respectively. The PRs were also similar when compared for ovulation induction with CC (6.8% versus 9.1%) and gonadotropins (13.2% versus 11.8%).
  
  
  CONCLUSIONS
  We conclude that fallopian sperm perfusion offers no advantage over IUI. Because the process of fallopian sperm perfusion is more time consuming and more costly (because of increased media usage), fallopian sperm perfusion does not seem indicated as a routine infertility therapy and should not replace IUI.
authors.affiliation: Division of Reproductive Endocrinology, Center for Human Reproduction, Chicago, Illinois 60610, USA.
authors.forename: V C
authors.initials: VC
authors.lastname: Karande
authors.forename: R
authors.initials: R
authors.lastname: Rao
authors.forename: D E
authors.initials: DE
authors.lastname: Pratt
authors.forename: M
authors.initials: M
authors.lastname: Balin
authors.forename: S
authors.initials: S
authors.lastname: Levrant
authors.forename: R
authors.initials: R
authors.lastname: Morris
authors.forename: A
authors.initials: A
authors.lastname: Dudkeiwicz
authors.forename: N
authors.initials: N
authors.lastname: Gleicher
mesh_terms: D000328:Adult; D005187:Fallopian Tubes; D005260:Female; D006801:Humans; D007246:Infertility / Q000628:therapy*; D007315:Insemination, Artificial; D008297:Male; D010062:Ovulation Induction; D010477:Perfusion; D011247:Pregnancy; D011446:Prospective Studies; D013094:Spermatozoa