[The long-term parenteral use of cyclophosphane in treating patients with systemic lupus erythematosus and central nervous system involvement].
In the treatment of systemic lupus erythematosus (SLE) with acute CNS affections good results may be obtained with intravenous cyclophosphamide (CP) + methylprednisolone followed with long-term parenteral CP administration. CNS abnormalities in SLE patients can be effectively managed by parenteral CP in combination with minimal-dose glucocorticoids given for 5-7 years.
Ivanova
M M
MM
Bliziuk
O I
OI
Travkina
I V
IV
D000284:Administration, Oral; D000328:Adult; D002493:Central Nervous System Diseases / Q000188:drug therapy* / Q000209:etiology; D002908:Chronic Disease; D003520:Cyclophosphamide / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007263:Infusions, Parenteral; D008180:Lupus Erythematosus, Systemic / Q000150:complications / Q000188:drug therapy*; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage; D011239:Prednisolone / Q000008:administration & dosage; D012074:Remission Induction; D013997:Time Factors
D003520:Cyclophosphamide; D011239:Prednisolone; D008775:Methylprednisolone
Dlitel'noe parenteral'noe primenenie tsiklofosfana v lechenii bol'nykh sistemnoĭ krasnoĭ volchankoĭ s porazheniem tsentral'noĭ nervnoĭ sistemy.