NGF: not just for neurons.
Nerve growth factor (NFF) is the prototypic member of a family of related neurotrophins (Nts). Although originally defined by its actions in the peripheral and central nervous systems, recent data indicate the presence of extensive interactions between NGF and the endocrine and immune systems steroid hormones are able to modulate the neurosomal expression NGF, while functional NGF receptors have been detected on cells of the immune system, and increased levels of NGF protein are found during the acute phase of diseases with a significant inflammatory component. These wider functions are likely to be of concern in any attempted therapeutic use of NGF.
Scully
J L
JL
Institute of Physiology, University of Basel, Switzerland.
Otten
U
U
D000818:Animals; D002450:Cell Communication; D002490:Central Nervous System / Q000502:physiology; D004702:Endocrine Glands / Q000502:physiology; D006801:Humans; D007107:Immune System / Q000502:physiology; D007249:Inflammation; D009414:Nerve Growth Factors / Q000494:pharmacology / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D010525:Peripheral Nerves / Q000502:physiology; D017475:Receptors, Nerve Growth Factor / Q000502:physiology*
D009414:Nerve Growth Factors; D017475:Receptors, Nerve Growth Factor