Clinical trial of a combination of rice bran fiber and cholestyramine for promotion of fecal excretion of retained polychlorinated dibenzofuran and polychlorinated biphenyl in Yu-Cheng patients.
A clinical trial using the combination of rice bran fiber (RBF) and cholestyramine (CHO) was carried out on Yu-Cheng patients in 1993-1994. By the analysis of blood and stool samples collected from the patients before and after (or during in the case of stool), it was verified that the administration of RBF and CHO is effective for excretion of polychlorinated biphenyl (PCB) (p < 0.05) and polychlorinated dibenzofuran (PCDF), especially 2, 3, 4, 7, 8-pentachlorodibenzofuran (p < 0.05). However, the degree of effectiveness varied upon individual patients from 60 to 160% for 2, 3, 4, 7, 8-pentachlorodibenzofuran, from 30 to 110% for 1, 2, 3, 4, 7, 8-hexachlorodibenzofuran and from 50 to 190% for PCB, respectively.
Iida
T
T
Fukuoka Institute of Health and Environmental Sciences.
Nakagawa
R
R
Hirakawa
H
H
Matsueda
T
T
Morita
K
K
Hamamura
K
K
Nakayama
J
J
Hori
Y
Y
Guo
Y L
YL
Chang
F M
FM
D001572:Benzofurans / Q000378:metabolism*; D002792:Cholestyramine Resin / Q000627:therapeutic use*; D000072338:Dibenzofurans, Polychlorinated; D004043:Dietary Fiber; D004350:Drug Residues; D005243:Feces / Q000737:chemistry*; D005506:Food Contamination; D006801:Humans; D012275:Oryza / Q000506:poisoning*; D010938:Plant Oils / Q000506:poisoning*; D011078:Polychlorinated Biphenyls / Q000378:metabolism / Q000506:poisoning*
D001572:Benzofurans; D000072338:Dibenzofurans, Polychlorinated; D004043:Dietary Fiber; D010938:Plant Oils; D002792:Cholestyramine Resin; D011078:Polychlorinated Biphenyls