Sequential levels of ceftriaxone in intervertebral disc removed as part of scoliosis surgery.
A single intravenous loading dose of 1 g ceftriaxone was injected at different intervals before surgery for correction of spinal scoliosis. Serum and concomitant disc samples were obtained and assay was performed using high-pressure liquid chromatography. Data showed that the antibiotic levels in intervertebral disc space reached 3.5 mcg/mg, which is above the minimum inhibitory concentration for most of the relevant pathogens, as early as 1 hour after intravenous administration. These therapeutic levels were maintained for more than 5 hours, an accepted period for most spinal surgical procedures.
Lang
R
R
Infectious Diseases Unit, Meir Hospital, Kfar-Saba, Israel.
Folman
Y
Y
Ravid
M
M
Bental
T
T
Gepstein
R
R
D000328:Adult; D002443:Ceftriaxone / Q000008:administration & dosage / Q000378:metabolism*; D002648:Child; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007403:Intervertebral Disc / Q000378:metabolism* / Q000601:surgery; D008297:Male; D011292:Premedication; D012600:Scoliosis / Q000601:surgery; D013997:Time Factors
D002443:Ceftriaxone