Transforming growth factor-beta 3.
Transforming Growth Factor-Beta (TGF-beta) is the general name for a family of naturally-occurring polypeptides which have multiple regulatory effects on cell proliferation and differentiation. Over the last decade it has become apparent that TGF-betas can be produced by most cell types and exert a wide range of effects in a context-dependent autocrine, paracrine or endocrine fashion via interactions with distinct receptors on the cell surface. This review summarizes current knowledge concerning the molecular and cellular biology of TGF-beta 3, the most recently described mammalian isoform, and focuses on those physiological actions which may lead to clinical applications, particularly in the indication areas of wound healing and chemoprotection.
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Ciba-Geigy Pharmaceuticals Division, Basel, Switzerland.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D015870:Gene Expression; D006801:Humans; D017433:Protein Structure, Secondary; D018125:Receptors, Transforming Growth Factor beta / Q000502:physiology*; D011994:Recombinant Proteins / Q000494:pharmacology / Q000627:therapeutic use; D015398:Signal Transduction; D016212:Transforming Growth Factor beta / Q000494:pharmacology / Q000502:physiology* / Q000627:therapeutic use; D014945:Wound Healing / Q000187:drug effects
D018125:Receptors, Transforming Growth Factor beta; D011994:Recombinant Proteins; D016212:Transforming Growth Factor beta