[Effects of cadmium on calcium homeostasis of isolated epithelial cells of proximal renal tubules].
Changes of intracellular calcium homeostasis in epithelial cell damage of renal tubules caused by cadmium and its relationship with the damage were studied in isolated tubular cells of rabbits. Results showed levels of free calcium (Ca++) in tubular cytoplasm increased significantly with the treatment of cadmium, and a series of cellular ultrastructure were damaged. A calcium channel blocker, phenothiazine, showed blocking and protecting effects on it. This suggested calcium overload played a very important role in kidney damage caused by cadmium.
Jiang
T
T
Instiute of Kidney Research, Sun Yet-sen University of Medical Sciences, Guangzhou.
Tan
B
B
Guan
W
W
D000818:Animals; D001693:Biological Transport, Active / Q000187:drug effects; D002104:Cadmium / Q000633:toxicity*; D002118:Calcium / Q000378:metabolism*; D002478:Cells, Cultured; D004847:Epithelial Cells; D005260:Female; D006706:Homeostasis / Q000187:drug effects; D007687:Kidney Tubules, Proximal / Q000166:cytology* / Q000648:ultrastructure; D008297:Male; D011817:Rabbits
D002104:Cadmium; D002118:Calcium