Effect of growth hormone treatment on glucose tolerance in a patient with cystinosis after kidney transplantation.
A 16 year-old boy with nephropathic cystinosis and kidney transplantation was successfully treated with rhGH because of growth retardation. After 15 months of rhGH therapy he developed impaired glucose tolerance. Various causes like cystinosis itself, the immunosuppressive therapy with cyclosporine A and cortisone, but rhGH too might have been the responsible factors for that. Treatment with rhGH was initiated again after 4 months of interruption of therapy because no relation between impaired glucose tolerance and GH could be established.
Kohlhauser
C
C
Department of Pediatrics, University of Vienna, Austria.
Balzar
E
E
Schober
E
E
Frisch
H
H
D000293:Adolescent; D003554:Cystinosis / Q000097:blood / Q000601:surgery*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000175:diagnosis*; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005500:Follow-Up Studies; D005951:Glucose Tolerance Test; D006442:Glycated Hemoglobin / Q000378:metabolism; D013006:Growth Hormone / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007279:Injections, Subcutaneous; D007676:Kidney Failure, Chronic / Q000097:blood / Q000601:surgery*; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000502:physiology*; D008297:Male; D011183:Postoperative Complications / Q000097:blood / Q000175:diagnosis*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects
D006442:Glycated Hemoglobin; D013006:Growth Hormone; D011994:Recombinant Proteins