Surface pressure-area isotherms of mixed cyclosporin-poly(isobutylcyanoacrylate) monolayers spread at the air/water interface.
The pi-A isotherms of mixed monolayers of cyclosporin and poly(isobutylcyanoacrylate) (PIBCA) show that the molecular areas of cyclosporin and PIBCA are additive regardless of the pH of the substrate or the physical state of the monolayers. All these mixed films collapse at the same surface pressure; therefore, application of the two-dimensional phase rule implies that cyclosporin and PIBCA are immiscible at the interface. This conclusion may have important implications with regard to the formulation of PIBCA-cyclosporin nanoparticles for cyclosporin administration, though further research in this direction will require consideration of the role played by the coadjuvants used for PIBCA polymerization during nanoparticle formation.
Miñones
J
J
Departamento de Fisico-Quimica, Facultad de Farmacia, Universidad de Santiago de Compostela, Spain.
Yebra-Pimentel
E
E
Conde
O
O
Iribarnegaray
E
E
Casas Parada
M
M
Vila Jato
J L
JL
Seijo
B
B
D003487:Cyanoacrylates / Q000737:chemistry*; D016572:Cyclosporine / Q000737:chemistry*; D004659:Enbucrilate; D006863:Hydrogen-Ion Concentration; D008567:Membranes, Artificial; D011108:Polymers / Q000737:chemistry*; D011312:Pressure; D013499:Surface Properties; D013816:Thermodynamics
D003487:Cyanoacrylates; D008567:Membranes, Artificial; D011108:Polymers; D016572:Cyclosporine; D004659:Enbucrilate