[Role of NMR in the diagnosis of atherosclerosis].
Diagnosis and prognosis of atherosclerosis can no longer be evaluated with morphological parameters only. A description of atherosclerotic plaque composition is necessary to study the mechanisms of plaque rupture, which depends on collagenous cap and lipid core thicknesses. NMR, as a biochemical imaging technique, allows visualization of these components using T1 contrast (mobile lipids), T2 contrast (cap vs. core), spin density (calcifications), diffusion imaging, 1H and 13C spectroscopy. Today, these imaging sequences allow to study in vitro the effects of interventional techniques such as angioplasty or atherectomy. Clinical investigations begin, which will attempt to develop in vivo microscopy and test the ability of NMR to predict plaque rupture.
Toussaint
J F
JF
Massachusetts General Hospital, Harvard Medical School, Et Service de Cardiologie, Hôpital Cochin, Paris.
D001161:Arteriosclerosis / Q000175:diagnosis*; D006801:Humans; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*
Rôle de l'IRM dans le diagnostic d'athérosclérose.