title: DNA replication. A familiar ring to DNA polymerase processivity.
abstract: Structural similarity reveals that prokaryotic and eukaryotic DNA polymerases share a mechanism for processivity--but the conservation of additional chromosomal replication mechanisms remains to be determined.
authors.affiliation: Division of Molecular Biology and Biochemistry, University of California, Berkeley 94720, USA.
authors.forename: C
authors.initials: C
authors.lastname: Wyman
authors.forename: M
authors.initials: M
authors.lastname: Botchan
mesh_terms: D000818:Animals; D003196:Computer Graphics; D004258:DNA Polymerase III / Q000737:chemistry / Q000378:metabolism; D004261:DNA Replication; D004259:DNA-Directed DNA Polymerase / Q000737:chemistry / Q000378:metabolism*; D004926:Escherichia coli / Q000378:metabolism; D005057:Eukaryotic Cells / Q000378:metabolism; D006801:Humans; D015394:Molecular Structure; D011387:Prokaryotic Cells / Q000378:metabolism; D018809:Proliferating Cell Nuclear Antigen / Q000737:chemistry / Q000378:metabolism; D012441:Saccharomyces cerevisiae / Q000378:metabolism
chemical_list: D018809:Proliferating Cell Nuclear Antigen; D004258:DNA Polymerase III; D004259:DNA-Directed DNA Polymerase