title: A new neuronal cell protecting substance, lavanduquinocin, produced by Streptomyces viridochromogenes.
abstract: A new neuronal cell protecting substance, lavanduquinocin was isolated from Streptomyces viridochromogenes 2942-SVS3. It consists of a carbazole skeleton with an ortho quinone function and a cyclolavandulyl moiety. Lavanduquinocin protected neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity with EC50 value 15.5 nm.
authors.affiliation: Institute of Cellular and Molecular Biosciences, University of Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shin-Ya
authors.forename: S
authors.initials: S
authors.lastname: Shimizu
authors.forename: T
authors.initials: T
authors.lastname: Kunigami
authors.forename: K
authors.initials: K
authors.lastname: Furihata
authors.forename: K
authors.initials: K
authors.lastname: Furihata
authors.forename: H
authors.initials: H
authors.lastname: Seto
mesh_terms: D000818:Animals; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured; D005285:Fermentation; D018698:Glutamic Acid / Q000633:toxicity; D051379:Mice; D015394:Molecular Structure; D051381:Rats; D011916:Rats, Inbred F344; D013302:Streptomyces
chemical_list: D002227:Carbazoles; C095334:lavanduquinocin; D018698:Glutamic Acid