Localisation of the human gene encoding the cytoskeletal protein talin to chromosome 9p.
The cytoskeletal protein talin is localised on the cytoplasmic face of the integrin family of adhesion receptors in cellular junctions with the extracellular matrix. Using polymerase chain reaction amplification and DNA from a panel of human-rodent somatic cell hybrids, we have assigned the talin gene to chromosome 9p. Deletions in 9p have been implicated in a variety of cancers, including malignant melanoma, and the concept that talin might be a candidate tumour suppressor gene is discussed.
Gilmore
A P
AP
Department of Biochemistry, University of Leicester, UK.
Ohanian
V
V
Spurr
N K
NK
Critchley
D R
DR
D000818:Animals; D001483:Base Sequence; D002874:Chromosome Mapping; D002899:Chromosomes, Human, Pair 9 / Q000235:genetics*; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006801:Humans; D006822:Hybrid Cells; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D012377:Rodentia; D016608:Talin / Q000235:genetics*; D014178:Translocation, Genetic
D016608:Talin