Absorption of bismuth from several bismuth compounds during in vivo perfusion of rat small intestine.
Evaluation of the amount of bismuth (Bi) absorbed from the gastrointestinal tract is important for assessment of the possible risks associated with the use of Bi compounds in the treatment of gastrointestinal disorders. We compared the absorption of Bi from media containing the equivalent of 1 g of elemental Bi from either Bi subnitrate (BSN), Bi subsalicylate (BSS), colloidal Bi subcitrate (CBS), Bi chloride (BiCl3), or Bi citrate (BCit) by an in vivo perfusion system of rat small intestine. The intestinal absorption was < 1% for all compounds, but higher from BCit and CBS than from BSN, BSS, and BiCl3. The dose dependency of Bi absorption from both CBS and BiCl3 in citrate buffer showed a nonlinear relationship between the concentration of Bi in perfusate and the concentration of Bi in blood after 60 min.
Slikkerveer
A
A
Toxicology Laboratory, University Hospital, Leiden, The Netherlands.
Helmich
R B
RB
van Der Voet
G B
GB
de Wolff
F A
FA
D000818:Animals; D001729:Bismuth / Q000097:blood / Q000493:pharmacokinetics*; D005260:Female; D066298:In Vitro Techniques; D007408:Intestinal Absorption / Q000502:physiology*; D007421:Intestine, Small / Q000378:metabolism*; D010477:Perfusion; D051381:Rats; D017208:Rats, Wistar; D012044:Regression Analysis
D001729:Bismuth