title: Effect of doxycycline on surgically induced osteoclast recruitment in the rat.
abstract: The influence of systemic doxycycline on the number of surgically induced osteoclasts was studied in young albino rats. Forty Wistar rats, aged 50 d at the start of the experiments, were randomly assigned to two groups. The experimental group (20 animals) received 0.5 mg/ml doxycycline added to the drinking water. Mucoperiosteal flaps were raised on the palatal aspect of left maxillary molars in all animals. Two rats from each group were killed daily during a post-operative period of 10 d, and specimens were prepared for light microscopy. Cellular counts in serial sections of crestal bone indicated a delay of initial surface colonization of 2 d. Statistical analysis revealed a smaller number of osteoclasts in doxycycline-treated animals as compared to control rats. In conclusion, systemic doxycycline suppresses recruitment of osteoclasts following surgery.
authors.affiliation: Department of Periodontology, University of Bergen, Norway.
authors.forename: H J
authors.initials: HJ
authors.lastname: Grevstad
authors.forename: O E
authors.initials: OE
authors.lastname: Bøe
mesh_terms: D016301:Alveolar Bone Loss / Q000517:prevention & control*; D000539:Alveolar Process / Q000601:surgery; D000704:Analysis of Variance; D000818:Animals; D004318:Doxycycline / Q000494:pharmacology*; D008297:Male; D010010:Osteoclasts / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D004318:Doxycycline