title: Intrasellar neuronal choristoma associated with growth hormone-producing pituitary adenoma containing amyloid deposits.
abstract: The histological, immunocytochemical, and ultrastructural features of an intrasellar neuronal choristoma associated with pituitary growth hormone (GH)-producing adenoma are reported. Immunohistochemistry studies and electron microscopy examination showed the adenoma cells to be positive for GH but negative for prolactin, and the neurons of the choristoma to have GH-releasing factor (GRF) neurosecretory activity. The adenoma also had many amyloid deposits in its extracellular space immunoreactive to GRF. This is the first report of the tumor containing amyloid deposits.
authors.affiliation: Department of Pathology, Hamamatsu University School of Medicine, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Iwase
authors.forename: S
authors.initials: S
authors.lastname: Nishizawa
authors.forename: S
authors.initials: S
authors.lastname: Baba
authors.forename: K
authors.initials: K
authors.lastname: Hinokuma
authors.forename: H
authors.initials: H
authors.lastname: Sugimura
authors.forename: S
authors.initials: S
authors.lastname: Nakamura
authors.forename: K
authors.initials: K
authors.lastname: Uemura
authors.forename: H
authors.initials: H
authors.lastname: Shirasawa
authors.forename: I
authors.initials: I
authors.lastname: Kino
mesh_terms: D000236:Adenoma / Q000737:chemistry / Q000150:complications / Q000378:metabolism*; D000682:Amyloid / Q000032:analysis*; D002828:Choristoma / Q000150:complications* / Q000473:pathology; D013006:Growth Hormone / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D010900:Pituitary Diseases / Q000473:pathology*; D010903:Pituitary Gland, Anterior; D010911:Pituitary Neoplasms / Q000737:chemistry / Q000150:complications / Q000378:metabolism*; D012658:Sella Turcica
chemical_list: D000682:Amyloid; D013006:Growth Hormone