Inhibitory effect of FUT-175 on the production of interleukin 8 and polymorphonuclear leukocyte elastase.
We investigated the inhibitory effects of a protease inhibitor, FUT-175, on the production of interleukin 8 (IL-8) and polymorphonuclear leukocyte elastase (PMNE) by polymorphonuclear leukocytes (PMN) and vascular endothelial cells. IL-8 production by PMN and vascular endothelial cells stimulated with lipopolysaccharide (LPS) was inhibited by FUT-175. This compound also inhibited PMNE production by PMN following LPS stimulation.
Kikuchi
M
M
Critical Care and Emergency Center, Iwate Medical University, Morioka, Japan.
Endo
S
S
Inada
K
K
Yamashita
H
H
Takakuwa
T
T
Nakae
H
H
Kasai
T
T
Baba
N
N
Yamada
Y
Y
D001550:Benzamidines; D004730:Endothelium, Vascular / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D006146:Guanidines / Q000494:pharmacology*; D006801:Humans; D016209:Interleukin-8 / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000097:blood; D019272:Leukocyte Elastase; D008070:Lipopolysaccharides / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors* / Q000096:biosynthesis / Q000097:blood; D011480:Protease Inhibitors / Q000494:pharmacology*; D013268:Stimulation, Chemical
D001550:Benzamidines; D006146:Guanidines; D016209:Interleukin-8; D008070:Lipopolysaccharides; D011480:Protease Inhibitors; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; C032855:nafamostat