title: Recurrent nasopharyngeal tumors: preliminary clinical results with interventional MR imaging--controlled laser-induced thermotherapy.
abstract: OBJECTIVE
  To evaluate magnetic resonance (MR) imaging-controlled laser-induced thermotherapy (LITT) in the treatment of recurrent head and neck tumors.
  
  
  METHODS
  Six patients with recurrent nasopharyngeal tumors (squamous cell carcinoma [n = 4], pleomorphic adenoma [n = 2]) underwent LITT with local anesthesia. A 7-F introducing sheath was inserted into the center of the tumor followed by a specially designed laser emitter. Therapy was monitored on-line with MR thermometry, and the amount of necrosis was estimated with dynamic and static contrast material-enhanced sequences.
  
  
  RESULTS
  All procedures were well tolerated with use of local anesthesia, with no clinically relevant side effects. MR thermometry depicted up to 15-mm-diameter areas of less signal intensity near the laser tip. Coagulative necrosis was achieved in all patients (volume range, 4-28 cm3), and clinical symptoms were reduced in four.
  
  
  CONCLUSIONS
  MR imaging-controlled LITT may be a safe, minimally invasive alternative in the treatment of recurrent head and neck tumors.
authors.affiliation: Department of Radiology, Humboldt-University of Berlin, Rudolf Virchow Clinic, Germany.
authors.forename: T J
authors.initials: TJ
authors.lastname: Vogl
authors.forename: M G
authors.initials: MG
authors.lastname: Mack
authors.forename: P
authors.initials: P
authors.lastname: Müller
authors.forename: C
authors.initials: C
authors.lastname: Phillip
authors.forename: H
authors.initials: H
authors.lastname: Böttcher
authors.forename: A
authors.initials: A
authors.lastname: Roggan
authors.forename: M
authors.initials: M
authors.lastname: Juergens
authors.forename: M
authors.initials: M
authors.lastname: Deimling
authors.forename: D
authors.initials: D
authors.lastname: Knöbber
authors.forename: P
authors.initials: P
authors.lastname: Wust
mesh_terms: D008949:Adenoma, Pleomorphic / Q000628:therapy; D000772:Anesthesia, Local; D002294:Carcinoma, Squamous Cell / Q000628:therapy; D002404:Catheterization / Q000295:instrumentation; D003131:Combined Modality Therapy; D003287:Contrast Media; D004867:Equipment Design; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D006979:Hyperthermia, Induced / Q000295:instrumentation; D017075:Laser Coagulation / Q000295:instrumentation; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D008991:Monitoring, Physiologic; D009303:Nasopharyngeal Neoplasms / Q000628:therapy*; D009336:Necrosis; D009339:Needles; D009364:Neoplasm Recurrence, Local / Q000628:therapy*; D009862:Online Systems; D015642:Radiology, Interventional; D014057:Tomography, X-Ray Computed
chemical_list: D003287:Contrast Media