Spinal abnormalities similar to ankylosing spondylitis in a 58-year-old woman with ochronosis.
Ochronotic arthropathy (spondylosis or peripheral arthropathy) is a late complication of alkaptonuria. There is a tendency for HLA-B27 positive patients with alkaptonuria to develop ochronotic spondylosis. A 58-year-old white woman, presented with ochronotic spondylosis. She was HLA-B27 positive. Her family history was positive for alkaptonuria. Ochronotic patients with HLA-B27 positivity develop spinal changes similar to ankylosing spondylitis (AS).
Kabasakal
Y
Y
Department of Rheumatology, Ege University Medical School, Izmir, Turkey.
Kiyici
I
I
Ozmen
D
D
Yagci
A
A
Gumusdis
G
G
D000474:Alkaptonuria / Q000150:complications / Q000235:genetics; D005260:Female; D015796:HLA-B27 Antigen / Q000032:analysis; D006801:Humans; D007592:Joint Diseases / Q000000981:diagnostic imaging* / Q000209:etiology / Q000276:immunology; D008875:Middle Aged; D009794:Ochronosis / Q000000981:diagnostic imaging* / Q000209:etiology / Q000276:immunology; D011859:Radiography; D013131:Spine / Q000000981:diagnostic imaging*; D013167:Spondylitis, Ankylosing / Q000000981:diagnostic imaging*
D015796:HLA-B27 Antigen