[Experience with other tumors: breast, ovary, brain tumors and sarcomas].
High-dose chemotherapy and autologous bone-marrow was widely tested in different solid tumors. This treatment is under investigation in metastatic and high-risk loco-regional breast cancer in France (Pegase protocol). There is few evidence of a role of high-dose chemotherapy in the first line treatment of poor-risk germ cell tumors. However the role of high-dose chemotherapy in the salvage setting of germ tumors is studied in an european randomized trial. At present there is no evidence of the role of this treatment in other solid tumors of adulthood.
Maraninchi
D
D
Institut Paoli-Calmette, Marseille, France.
Droz
J P
JP
D000970:Antineoplastic Agents / Q000627:therapeutic use*; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D016026:Bone Marrow Transplantation; D001932:Brain Neoplasms / Q000188:drug therapy / Q000628:therapy*; D001943:Breast Neoplasms / Q000188:drug therapy / Q000453:epidemiology / Q000628:therapy*; D003131:Combined Modality Therapy; D004305:Dose-Response Relationship, Drug; D005260:Female; D005602:France / Q000453:epidemiology; D006801:Humans; D009362:Neoplasm Metastasis; D009369:Neoplasms / Q000188:drug therapy / Q000628:therapy*; D010051:Ovarian Neoplasms / Q000188:drug therapy / Q000628:therapy*; D011379:Prognosis; D016879:Salvage Therapy; D012509:Sarcoma / Q000188:drug therapy / Q000628:therapy*; D014182:Transplantation, Autologous
D000970:Antineoplastic Agents
Expérience dans les autres tumeurs: sein, ovaire, tumeurs cérébrales, sarcomes.