HLA-DP antibodies in patients awaiting renal transplantation.
Sera from 505 patients awaiting renal transplantation with known panel-reactive cytotoxic antibody (PRA) status were tested for HLA-DP antibodies of the IgG class by means of the monoclonal antibody immobilization of leukocyte antigens (MAILA) technique. The overall incidence of HLA-DP antibodies was 7.3%. A positive HLA-DP antibody status correlated only weakly (r = 0.23) with a positive cytotoxic antibody status. After retrospective analysis, patients with HLA-DP antibodies prior to retransplantation revealed a significantly (P < 0.025) higher graft function rate than HLA-DP-negative patients. One patient was found to possess IgG HLA-DP autoantibodies prior to transplantation; thus far, his graft has been functioning for more than 2 years.
Pfeiffer
K
K
Institut für Immunologie, Universitätsklinikum Essen, Germany.
Vögeler
U
U
Albrecht
K H
KH
Eigler
F W
FW
Buchholz
B
B
Grosse-Wilde
H
H
D000906:Antibodies / Q000097:blood*; D005260:Female; D006085:Graft Survival; D006682:HLA-DP Antigens / Q000276:immunology*; D006801:Humans; D016030:Kidney Transplantation / Q000276:immunology*; D008297:Male
D000906:Antibodies; D006682:HLA-DP Antigens