title: Enhancement of interleukin-6 production by fibrinogen degradation product D in human peripheral monocytes and perfused murine liver.
abstract: The effect of fibrinogen degradation products D and E (FDP-D, FDP-E) on IL-6 production in perfused mouse livers and peripheral monocytes is studied. Similarly to bacterial endotoxin FDP-D is highly potent to augment the IL-6 production measured in perfused mouse livers, while FDP-E is not stimulatory. FDP-D but not FDP-E is able to stimulate the in vitro IL-6 production of human peripheral monocytes, as well. Plasmin alone is almost ineffective on IL-6 production both in perfused livers and monocytes. Our findings suggest a direct positive feedback circuit, among fibrinogen, FDP and IL-6.
authors.affiliation: First Department of Biochemistry, Semmelweis University of Medicine, Budapest, Hungary.
authors.forename: J
authors.initials: J
authors.lastname: Mandl
authors.forename: M
authors.initials: M
authors.lastname: Csala
authors.forename: I
authors.initials: I
authors.lastname: Léránt
authors.forename: G
authors.initials: G
authors.lastname: Bánhegyi
authors.forename: J
authors.initials: J
authors.lastname: Biró
authors.forename: R
authors.initials: R
authors.lastname: Machovich
authors.forename: A
authors.initials: A
authors.lastname: Falus
mesh_terms: D000328:Adult; D000818:Animals; D005338:Fibrin Fibrinogen Degradation Products / Q000502:physiology*; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D051379:Mice; D009000:Monocytes / Q000378:metabolism*; D015854:Up-Regulation / Q000276:immunology
chemical_list: D005338:Fibrin Fibrinogen Degradation Products; D015850:Interleukin-6