title: Safety and pharmacokinetics of vitamin A therapy for infants with respiratory syncytial virus infections.
abstract: Infants with respiratory syncytial virus infection have low serum vitamin A levels. We treated 21 respiratory syncytial virus-infected children with 12,500 to 25,000 IU of oral vitamin A. Vitamin A levels were normalized at 6 h, and none of the children experienced vitamin A toxicity or exacerbation of respiratory illness. Vitamin A treatment of previously healthy respiratory syncytial virus-infected infants at these doses is safe and well tolerated.
authors.affiliation: Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Neuzil
authors.forename: W C
authors.initials: WC
authors.lastname: Gruber
authors.forename: F
authors.initials: F
authors.lastname: Chytil
authors.forename: M T
authors.initials: MT
authors.lastname: Stahlman
authors.forename: B S
authors.initials: BS
authors.lastname: Graham
mesh_terms: D006801:Humans; D007223:Infant; D018357:Respiratory Syncytial Virus Infections / Q000378:metabolism*; D018113:Respiratory Syncytial Virus, Human; D014801:Vitamin A / Q000009:adverse effects / Q000493:pharmacokinetics*
chemical_list: D014801:Vitamin A