title: Oral therapy with flurithromycin in ear, nose and throat infections.
abstract: In this study efficacy and tolerability of flurithromycin ethylsuccinate (FE) were evaluated in ear, nose and throat infections. One hundred and three patients were treated with FE tablets 375 mg 12-hourly for a mean duration of treatment of 8.2 days and they were divided into groups according to the pathology: pharyngitis/tonsillitis (chronic 7, acute 38), rhinosinusitis (chronic 7, acute 12), otitis (chronic 6, acute 32) and sialadenitis (acute 1). Patients evaluable for clinical efficacy were 101, among them a complete recovery was registered in 88.2%, an improvement in 9.9% and a treatment failure in 1.9%. Bacteriological evaluation was possible in 95 patients, showing the eradication of the pathogen in 94.7%. Tolerability was judged to be excellent in 81.6%, good in 15.5% and discrete in 2.9%. These results demonstrate that FE is safe and effective in the treatment of infections established on acute or chronic inflammatory states.
authors.affiliation: Otorhinolaryngologic Department, Policlinico S. Matteo, University of Pavia, Italy.
authors.forename: G B
authors.initials: GB
authors.lastname: Galioto
authors.forename: D
authors.initials: D
authors.lastname: Passali
authors.forename: G B
authors.initials: GB
authors.lastname: Catalano
authors.forename: E
authors.initials: E
authors.lastname: Mevio
authors.forename: A M
authors.initials: AM
authors.lastname: Lepore
authors.forename: L
authors.initials: L
authors.lastname: Romoli
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001424:Bacterial Infections / Q000188:drug therapy*; D001774:Blood Chemical Analysis; D004917:Erythromycin / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007297:Inpatients; D008297:Male; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D010031:Otitis / Q000188:drug therapy; D010045:Outpatients; D010612:Pharyngitis / Q000188:drug therapy; D012141:Respiratory Tract Infections / Q000188:drug therapy*; D012793:Sialadenitis / Q000188:drug therapy; D012852:Sinusitis / Q000188:drug therapy; D014069:Tonsillitis / Q000188:drug therapy
chemical_list: C045925:flurithromycin; D004917:Erythromycin