title: Effects of chlorhexidine gluconate on the development of spores of Bacillus subtilis.
abstract: The effects of sublethal concentrations of the membrane-active agent chlorhexidine gluconate (CHG) on the growth rate and sporulation of Bacillus subtilis vegetative MB2 cells have been investigated. CHG increased the mean generation time (Mgt) of vegetative cells in casein medium. It also affected spore development: as CHG concentrations increased, spore index (SI) values decreased and sensitivity to both toluene and heat increased.
authors.affiliation: Welsh School of Pharmacy, University of Wales College of Cardiff, UK.
authors.forename: A G
authors.initials: AG
authors.lastname: Knott
authors.forename: A D
authors.initials: AD
authors.lastname: Russell
mesh_terms: D001412:Bacillus subtilis / Q000187:drug effects* / Q000502:physiology; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000494:pharmacology; D013171:Spores, Bacterial / Q000187:drug effects / Q000254:growth & development
chemical_list: C010882:chlorhexidine gluconate; D002710:Chlorhexidine