Anti-inflammatory and diuretic activity of a new class of compounds--Schiff bases of 3-amino-2-methylquinazolin 4(3H)-ones.
Eighteen Schiff Bases of 3-amino-2-methylquinazolin-4(3H)-ones were synthesised and screened for anti-inflammatory and diuretic activity. Anti-inflammatory activity was identified in PNG-1, PNG-13, PNG-14, PNG-15 and PNG-17.
Mishra
P
P
Department of Pharmaceutical Sciences, Dr. Harisingh Gour Vishvavidyalaya, Sagar.
Gupta
P N
PN
Shakya
A K
AK
Shukla
R
R
Srimal
R C
RC
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D004232:Diuretics / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D004487:Edema / Q000188:drug therapy; D005260:Female; D005665:Furosemide / Q000008:administration & dosage / Q000494:pharmacology; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010653:Phenylbutazone / Q000008:administration & dosage / Q000494:pharmacology; D011799:Quinazolines / Q000138:chemical synthesis / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017207:Rats, Sprague-Dawley; D012545:Schiff Bases / Q000138:chemical synthesis / Q000494:pharmacology; D013329:Structure-Activity Relationship
D000894:Anti-Inflammatory Agents, Non-Steroidal; D004232:Diuretics; D011799:Quinazolines; D012545:Schiff Bases; D005665:Furosemide; D010653:Phenylbutazone