Comparative study of the dialysability of iobitridol and iohexol in the rat with impaired renal function.
OBJECTIVE
To assess the dialysability of iobitridol, a comparative study with iohexol was conducted in the rat over 4 hours.


METHODS
After ligature of the renal veins and arteries, a group of animals was submitted to continuous peritoneal dialysis, while the remainder were not.


RESULTS
In the event of total renal failure, biliary excretion rose from 0.4 to 9% for iobitridol and from 2 to 16% for iohexol. In the rats submitted to peritoneal dialysis, biliary excretion decreased to 5% in the iobitridol group and to 13% in the iohexol group. Further, 18% of the test substances were eliminated in the dialysis liquid.


CONCLUSIONS
As their physicochemical characteristics are very similar, the differences between the biliary excretion levels of these 2 media may be caused by a factor related to their respective molecular conformations.
Dencausse
A
A
Laboratoire Guerbet, Roissy, France.
Chambon
C
C
Violas
X
X
Bonnemain
B
B
D000818:Animals; D001659:Biliary Tract / Q000378:metabolism*; D003287:Contrast Media; D005069:Evaluation Studies as Topic; D007472:Iohexol / Q000031:analogs & derivatives* / Q000493:pharmacokinetics*; D008297:Male; D010530:Peritoneal Dialysis; D051381:Rats; D017207:Rats, Sprague-Dawley; D051437:Renal Insufficiency / Q000378:metabolism*
D003287:Contrast Media; C093233:iobitridol; D007472:Iohexol