title: Differential diagnosis of CNS lesions in AIDS patients by FDG-PET.
abstract: OBJECTIVE
  The aim of this study was to evaluate the potential of FDG-PET in the differential diagnosis of CNS lesions in patients with AIDS, particularly to differentiate between toxoplasmosis and lymphoma.
  
  
  METHODS
  We examined 11 AIDS patients, 6 with toxoplasmosis, 1 with a tuberculoma, and 4 with a primary CNS lymphoma. The FDG uptake within the lesion was compared with the uptake in a contralateral brain area [standardized uptake value (SUV)].
  
  
  RESULTS
  In all subjects with cerebral infections (toxoplasmosis, tuberculoma), the SUV ratio was significantly (p < 0.05) lower than the SUV ratio in patients with lymphoma (range of 0.3-0.7 vs. 1.7-3.1) with no overlap of the uptake values.
  
  
  CONCLUSIONS
  In conclusion, FDG-PET may help to characterize these lesions metabolically and play an important role in the clinical management of AIDS patients with CNS involvement.
authors.affiliation: Department of Nuclear Medicine, Curatorium for Immunodeficiency, Munich, Germany.
authors.forename: K
authors.initials: K
authors.lastname: Villringer
authors.forename: H
authors.initials: H
authors.lastname: Jäger
authors.forename: M
authors.initials: M
authors.lastname: Dichgans
authors.forename: S
authors.initials: S
authors.lastname: Ziegler
authors.forename: J
authors.initials: J
authors.lastname: Poppinger
authors.forename: M
authors.initials: M
authors.lastname: Herz
authors.forename: C
authors.initials: C
authors.lastname: Kruschke
authors.forename: S
authors.initials: S
authors.lastname: Minoshima
authors.forename: H W
authors.initials: HW
authors.lastname: Pfister
authors.forename: M
authors.initials: M
authors.lastname: Schwaiger
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000000981:diagnostic imaging*; D000328:Adult; D001921:Brain / Q000000981:diagnostic imaging; D016543:Central Nervous System Neoplasms / Q000000981:diagnostic imaging*; D003847:Deoxyglucose / Q000031:analogs & derivatives*; D003937:Diagnosis, Differential; D005069:Evaluation Studies as Topic; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000000981:diagnostic imaging*; D008297:Male; D013997:Time Factors; D014055:Tomography, Emission-Computed; D016781:Toxoplasmosis, Cerebral / Q000000981:diagnostic imaging*; D016862:Tuberculoma, Intracranial / Q000000981:diagnostic imaging*
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose