Effects of selected synthetic compounds on growth of Mucor rouxii.
The in vitro activity of four synthetic compounds was tested on fungal cells from Mucor rouxii. The compounds included phenylenediamine, two phenolamines, and quinone. At the concentrations tested (10(-2)-10(-4)M) the compounds exhibited antifungal activity, with the exception of quinone. On the basis of their effects on spore germination, and development of hyphae, phenylenediamine was the more active. The mechanism of action of the compounds is still unknown, but hyphae show morphological alterations and disturb the distribution of calcofluor in the cell wall. This suggests variations in the genesis of the cell wall.
Sabanero
M
M
Instituto de Investigación en Biología Experimental, Facultad de Química, Universidad de Guanajuato, Mexico.
Rojas
E
E
Torres
V
V
Farfán
N
N
Flores
A
A
Contreras
R
R
D000814:Aniline Compounds / Q000138:chemical synthesis / Q000494:pharmacology*; D001542:Benomyl / Q000138:chemical synthesis / Q000494:pharmacology; D002473:Cell Wall / Q000187:drug effects; D003470:Culture Media; D009089:Mucor / Q000187:drug effects* / Q000254:growth & development; D010655:Phenylenediamines / Q000138:chemical synthesis / Q000494:pharmacology*; D011809:Quinones / Q000138:chemical synthesis / Q000494:pharmacology*
D000814:Aniline Compounds; D003470:Culture Media; D010655:Phenylenediamines; D011809:Quinones; D001542:Benomyl