title: Efficacy of topical corticosteroids on irritant skin reactions.
abstract: Topical corticosteroids are frequently used in the treatment of irritant contact dermatitis (ICD). The efficacy of this treatment has, however, not been thoroughly established, and experimental studies on the topic have provided conflicting results. The aim of the present study was to evaluate the effect of potent topical corticosteroids on experimentally-induced irritant skin reactions in a double-blind, vehicle-controlled study. 16 healthy volunteers had sodium lauryl sulfate patch tests symmetrically applied to the upper arms. After removal of patch tests, a potent topical corticosteroid (betamethasone-17-valerate) was applied to the irritant skin reaction on one arm, while the corresponding vehicle was applied to the irritant skin reaction on the opposite arm 2x daily for 7 days. Reactions were evaluated by measurement of transepidermal water loss (TEWL) and erythema. After 7 days, statistically significant lower values of TEWL and erythema were found in corticosteroid-treated, compared to the vehicle-treated, skin reactions. The results indicate that topical corticosteroids improve healing of ICD.
authors.affiliation: Department of Dermatology, Gentofte Hospital, University of Copenhagen, Denmark.
authors.forename: D W
authors.initials: DW
authors.lastname: Ramsing
authors.forename: T
authors.initials: T
authors.lastname: Agner
mesh_terms: D000287:Administration, Topical; D000328:Adult; D000893:Anti-Inflammatory Agents / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D003877:Dermatitis, Contact / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D017453:Dermatitis, Irritant / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D004311:Double-Blind Method; D004485:Eczema / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D004890:Erythema / Q000188:drug therapy; D005260:Female; D005938:Glucocorticoids; D006801:Humans; D008297:Male; D008875:Middle Aged; D010328:Patch Tests; D012869:Skin Absorption / Q000187:drug effects; D012967:Sodium Dodecyl Sulfate; D016896:Treatment Outcome; D014870:Water Loss, Insensible / Q000187:drug effects
chemical_list: D000893:Anti-Inflammatory Agents; D005938:Glucocorticoids; D012967:Sodium Dodecyl Sulfate