Gene rearrangement studies on lymphoma of the lung: report of a case.
We describe herein how true lymphoma of the lung was differentiated from pseudolymphoma in a 45-year-old woman presenting with pulmonary infiltrates. Although segmental resection revealed typical histologic findings of pseudolymphoma of the lung and immunohistochemical studies did not demonstrate a monoclonal proliferation, Southern blot analysis of the frozen tissue revealed rearrangements in the heavy and light chains of the immunoglobulin gene, with no T-cell receptor gene rearrangement suggestive of a lymphoproliferative disorder. These findings indicate that the identification of gene rearrangement may be utilized to distinguish between true lymphoma and pseudolymphoma.
Aoki
T
T
Second Department of Surgery, National Defense Medical College, Saitama, Japan.
Watanabe
M
M
Takagi
K
K
Tanaka
S
S
Aida
S
S
D015139:Blotting, Southern; D003937:Diagnosis, Differential; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D007143:Immunoglobulin Heavy Chains / Q000235:genetics; D007147:Immunoglobulin Light Chains / Q000235:genetics; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000175:diagnosis / Q000235:genetics*; D008175:Lung Neoplasms / Q000175:diagnosis / Q000235:genetics*; D008223:Lymphoma / Q000175:diagnosis; D008875:Middle Aged; D011948:Receptors, Antigen, T-Cell / Q000235:genetics
D007143:Immunoglobulin Heavy Chains; D007147:Immunoglobulin Light Chains; D011948:Receptors, Antigen, T-Cell