title: Alterations in heart rate and pupillary response in persons with organic solvent exposure.
abstract: Cardiac and pupillary reactivity were examined in 25 persons with a history of exposure to organic solvents and 19 nonexposed controls during performance of a counting and a choice reaction task. The solvent-exposed group demonstrated an atypical pattern of responding across tasks. While control subjects showed a decline in heart rate across the two conditions (e.g., habituation), exposed persons had an increase in heart rate. Initial pupil diameter was similar for both groups, but only the control subjects exhibited habituation across the two tasks. In the exposed group, higher heart rate was not associated with higher levels of self-reported anxiety. Anticipatory cardiac deceleration preceding unpredictable events was significantly less in the exposed group, but there were no significant group differences on poststimulus acceleration. The results suggest that persons with solvent exposure have a deficiency in the allocation of attention (reduced anticipatory deceleration and decreased pupillary dilation). It is further suggested that difficulty in the allocation of attention produces an increase in tonic sympathetic levels when confronted with a cognitively challenging task. In this experiment, in which the choice reaction task was purposely presented last, and was apparently more challenging for exposed persons, a failure to exhibit autonomic habituation over the course of the session characterized the solvent-exposed group.
authors.affiliation: Western Psychiatric Institute and Clinic, Department of Psychiatry, University of Pittsburgh School of Medicine, PA, USA.
authors.forename: L A
authors.initials: LA
authors.lastname: Morrow
authors.forename: S R
authors.initials: SR
authors.lastname: Steinhauer
mesh_terms: D000328:Adult; D001143:Arousal / Q000187:drug effects; D001288:Attention / Q000187:drug effects; D001342:Autonomic Nervous System Diseases / Q000139:chemically induced / Q000175:diagnosis; D001794:Blood Pressure / Q000187:drug effects*; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009440:Neurasthenia / Q000139:chemically induced / Q000175:diagnosis / Q000523:psychology; D009460:Neurologic Examination / Q000187:drug effects*; D009483:Neuropsychological Tests; D009784:Occupational Diseases / Q000139:chemically induced / Q000175:diagnosis / Q000523:psychology; D012016:Reference Values; D012025:Reflex, Pupillary / Q000187:drug effects*; D012997:Solvents / Q000009:adverse effects*; D019966:Substance-Related Disorders / Q000175:diagnosis* / Q000523:psychology
chemical_list: D012997:Solvents