[The treatment with intramuscular interferon of female genital condylomatosis: beta-IFN vs alfa-2a-IFN].
The authors have investigated the efficacy of i.m. therapy with interferon (IFN) in the treatment of female genital condylomatosis: 94 consecutive patients underwent a randomized therapy with two different IFNs: beta-IFN and alpha-2A-IFN (3,000.000 UI i.m. on alternate days for 4 weeks). A total and/or partial response was observed in 76.5% of cases (72/94). Observed response was unrelated with used IFN, independently of type and seat of treated lesion. There was only an important difference between the two treatments in the incidence of side-effects and drop-out (31% and 6.3% with alpha-2A-IFN and 14.8% and 2.1% with beta-IFN). Systemic therapy with IFN is a good alternative to destructive techniques in the treatment of HPV-associated pathology of female lower genital tract.
Bernasconi
F
F
Divisione di Ostetricia e Ginecologia, Ospedale di Desio (Milano), Regione Lombardia, USSL n. 63.
Galli
F
F
Ersettigh
G
G
Arienti
S
S
D000328:Adult; D003218:Condylomata Acuminata / Q000628:therapy*; D005260:Female; D005831:Genital Diseases, Female / Q000628:therapy*; D006801:Humans; D007273:Injections, Intramuscular; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000008:administration & dosage* / Q000009:adverse effects; D016899:Interferon-beta / Q000008:administration & dosage* / Q000009:adverse effects; D011446:Prospective Studies; D011994:Recombinant Proteins; D012074:Remission Induction; D013997:Time Factors; D002583:Uterine Cervical Neoplasms / Q000628:therapy; D002578:Uterine Cervical Dysplasia / Q000628:therapy
D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D016899:Interferon-beta
Trattamento con interferone per via intra-muscolare della condilomatosi genitale femminile: B-IFN vs alfa 2A-IFN.