title: [Calcitriol: role in the regulation of erythropoiesis, use in the treatment of renal anemia].
abstract: The efficiency of combined therapy (erythropoietin + calcitriol) used in 8 patients with chronic renal failure on programmed hemodialysis was comparatively evaluated with erythropoietin monotherapy employed in 9 patients with the same disease on hemodialysis which represented a control group. The anti-anemia effect was achieved on the average of 5 weeks earlier in the group of patients given the combined therapy than that in the controls. The differences between the two groups were statistically significant in the rate of anti-anemia effect achievement. Possible mechanisms by which calcitriol enhances the anti-anemia effect of erythropoietin, i.e. the mediated effects and direct action of calcitriol on erythropoiesis, are discussed in the paper.
authors.forename: A Iu
authors.initials: AIu
authors.lastname: Nikolaev
authors.forename: P V
authors.initials: PV
authors.lastname: Klepikov
authors.forename: S V
authors.initials: SV
authors.lastname: Lashutin
authors.forename: A V
authors.initials: AV
authors.lastname: Kukhtevich
mesh_terms: D000328:Adult; D000740:Anemia / Q000188:drug therapy* / Q000209:etiology*; D002117:Calcitriol / Q000008:administration & dosage / Q000502:physiology* / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D004920:Erythropoiesis; D004921:Erythropoietin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000628:therapy; D008297:Male; D008875:Middle Aged; D006435:Renal Dialysis; D013997:Time Factors
chemical_list: D004921:Erythropoietin; D002117:Calcitriol
vernacular_title: Kal'tsitriol: rol' v reguliatsii éritropoéza, primenenie v lechenii pochechnoĭ anemii.