An important role for chromosome 17, band q25, in the histogenesis of alveolar soft part sarcoma.
A cytogenetic study of two cases of alveolar soft part sarcoma showed near-diploid karyotypes with multiple chromosomal rearrangements. An abnormality of the long arm of chromosome 17, involving band q25, is present in both cases and in 2 of 4 cases in the literature. This recurrent structural abnormality probably plays an important role in the histogenesis of this unusual neoplasm and therefore is important for further molecular investigation.
van Echten
J
J
Department of Medical Genetics, University Hospital of Groningen, The Netherlands.
van den Berg
E
E
van Baarlen
J
J
van Noort
G
G
Vermey
A
A
Dam
A
A
Molenaar
W M
WM
D000328:Adult; D002869:Chromosome Aberrations / Q000473:pathology*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002886:Chromosomes, Human, Pair 17; D005260:Female; D006258:Head and Neck Neoplasms / Q000235:genetics*; D006801:Humans; D008875:Middle Aged; D018234:Sarcoma, Alveolar Soft Part / Q000235:genetics*; D013848:Thigh