title: [Expression of E-cadherin as related to prognostic factors and survivals in breast cancer].
abstract: E-cadherin (E-CD) expression and its clinicopathological implication were investigated in 26 patients with breast cancer by immunohistochemical staining. 12 out of 26 primary lesions (46%) express strong and homogeneous expression of E-cadherin (preserved type), while in 14 cases (54%), degree of E-CD expression was reduced, i.e., 8 patients with heterogeneous staining, 2 cases with weak but homogeneous, and 4 cases with lost expression of E-CD (reduced type). However, there was no statistically significant correlation among decrease of E-CD expression, histological features, and advanced stages of breast cancer. Analysis on survivals showed better prognosis in the group with preserved E-CD expression than without E-CD (follow up was more than 96 months or until death). These findings suggests that the patients with decreased E-CD expression may be associated with metastasis resulting in poor prognosis, and E-CD expression could be one of the prognostic factors.
authors.affiliation: Department of Surgery, Faculty of Medicine, Tokyo Medical and Dental University.
authors.forename: R
authors.initials: R
authors.lastname: Hirayama
authors.forename: Z
authors.initials: Z
authors.lastname: Nihei
authors.forename: T
authors.initials: T
authors.lastname: Osanai
authors.forename: W
authors.initials: W
authors.lastname: Ichikawa
authors.forename: K
authors.initials: K
authors.lastname: Yoshinaga
authors.forename: S
authors.initials: S
authors.lastname: Sawai
authors.forename: Y
authors.initials: Y
authors.lastname: Mishima
mesh_terms: D001943:Breast Neoplasms / Q000401:mortality*; D015820:Cadherins / Q000032:analysis*; D005260:Female; D006801:Humans; D008875:Middle Aged; D009362:Neoplasm Metastasis; D011379:Prognosis
chemical_list: D015820:Cadherins