title: Blood volume and erythropoiesis in the rat during spaceflight.
abstract: A decreased red blood cell mass (RBCM) and plasma volume (PV) have been consistently found in humans after return from spaceflight. Rats flown on the Spacelab Life Sciences-1 mission were studied to assess changes in RBCM, PV, erythropoiesis, and iron economy. The RBCM and PV increased in both ground control and flight animals as expected for growing rats. However on landing day, both the RBCM and PV, when normalized for body mass, were significantly decreased in the spaceflight animals. During an 8-d postflight observation period, iron incorporation into circulating red blood cells was diminished in the flight animals. During the first 4 d postflight, increases in reticulocyte counts were significantly smaller in the flight than the control animals. Fewer erythropoietin-responsive progenitor cells were recovered from the bone marrow of flight animals after landing than control rats. Serum erythropoietin (EPO) levels were the same in both groups. Thus, rats subjected to a 9-d spaceflight had less increase in RBCM than controls and diminished erythropoiesis during an 8-d post-spaceflight observation period. The rat, like humans, appears to require a smaller blood volume in microgravity.
authors.affiliation: Baylor College of Medicine, Houston, TX, USA.
authors.forename: M M
authors.initials: MM
authors.lastname: Udden
authors.forename: T B
authors.initials: TB
authors.lastname: Driscoll
authors.forename: L A
authors.initials: LA
authors.lastname: Gibson
authors.forename: C S
authors.initials: CS
authors.lastname: Patton
authors.forename: M H
authors.initials: MH
authors.lastname: Pickett
authors.forename: J B
authors.initials: JB
authors.lastname: Jones
authors.forename: R
authors.initials: R
authors.lastname: Nachtman
authors.forename: Z
authors.initials: Z
authors.lastname: Allebban
authors.forename: A T
authors.initials: AT
authors.lastname: Ichiki
authors.forename: R D
authors.initials: RD
authors.lastname: Lange
mesh_terms: D000818:Animals; D001772:Blood Cell Count; D001810:Blood Volume; D001854:Bone Marrow Cells; D004905:Erythrocyte Aging; D015672:Erythroid Precursor Cells / Q000473:pathology; D004920:Erythropoiesis; D004921:Erythropoietin / Q000097:blood; D007501:Iron / Q000097:blood; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D017701:Reticulocyte Count; D013026:Space Flight
chemical_list: D004921:Erythropoietin; D007501:Iron