Relationship of haptoglobin polymorphism to malaria in the Solomon Islands.
Haptoglobin (Hp) polymorphism and its relationship to malaria infections was examined in Solomon Islanders under 25 years of age. The slide positive rate for malaria was 48% (53/111): Plasmodium vivax (Pv) 21 cases, Plasmodium falciparum (Pf) 16 cases and the remaining 16 were a mixture of Pv/Pf/P. malariae. Of 111 subjects examined, 17% (19 subjects) were ahaptoglobinemic (HpO). No association was observed between HpO and parasitemia, gender, anemia, serum insulin-like growth factor-1 (IGF-1) level, blood glucose level and enlargement of the spleen. These results suggest that malaria may not be the major cause of HpO in the people of the Solomon Islands.
Mizushima
Y
Y
First Department of Internal Medicine, Toyama Medical and Pharmaceutical University.
Kato
H
H
Ohmae
H
H
Tanaka
T
T
Bobogare
A
A
Ishii
A
A
D000293:Adolescent; D000328:Adult; D000818:Animals; D000962:Antimalarials / Q000627:therapeutic use; D001786:Blood Glucose / Q000378:metabolism; D002648:Child; D002675:Child, Preschool; D005260:Female; D006242:Haptoglobins / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism; D008288:Malaria / Q000097:blood* / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics; D008297:Male; D008542:Melanesia / Q000453:epidemiology; D018512:Parasitemia / Q000188:drug therapy / Q000453:epidemiology / Q000235:genetics*; D010641:Phenotype; D011110:Polymorphism, Genetic; D012424:Rural Population
D000962:Antimalarials; D001786:Blood Glucose; D006242:Haptoglobins; D007334:Insulin-Like Growth Factor I