title: The Edinburgh City Hospital cohort: analysis of enrollment, progression and mortality by baseline covariates.
abstract: We describe baseline characteristics, enrollment, progression and mortality of the Edinburgh City Hospital HIV cohort. There were 431 men and 191 (31%) women; 439 (71%) infected via injection drug use (IDU); 92 (15%) via homosexual intercourse; 84 (13%) via heterosexual intercourse and 7 from blood products. Median annual rate of CD4 cell loss was 49 (90% range: 15-146); Both homosexual men and patients aged > 40 years at enrollment lost CD4 cells significantly more quickly. In multifactorial analysis controlled for baseline CD4 count and IgA, there was no gender effect, but young patients (< 25 years) progressed significantly more slowly to AIDS (RR 0.4, p = 0.00). Homosexual men progressed significantly more quickly than IDUs, with adjusted relative risks (RR) of 2.9 (p = 0.00), 2.5 (p = 0.01) and 1.5 (p = 0.1) for progression to CDC stage IV, AIDS and death, respectively. The three-year survival rate post-AIDS was 25% (SE 4.3) and there was no gender effect on survival. There was, however, an age effect whereby individuals diagnosed with AIDS in their 40s or later showed poorer survival (RR 1.9, p = 0.04). Zidovudine treatment after an AIDS diagnosis significantly lengthened post-AIDS survival (RR 0.5, p = 0.08).
authors.affiliation: Regional Infectious Disease Unit, City Hospital, Edinburgh.
authors.forename: R P
authors.initials: RP
authors.lastname: Brettle
authors.forename: A J
authors.initials: AJ
authors.lastname: McNeil
authors.forename: S M
authors.initials: SM
authors.lastname: Gore
authors.forename: A G
authors.initials: AG
authors.lastname: Bird
authors.forename: C S
authors.initials: CS
authors.lastname: Leen
authors.forename: A
authors.initials: A
authors.lastname: Richardson
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000401:mortality; D000328:Adult; D018791:CD4 Lymphocyte Count; D015331:Cohort Studies; D018450:Disease Progression; D005260:Female; D015658:HIV Infections / Q000175:diagnosis / Q000276:immunology / Q000401:mortality*; D006801:Humans; D008297:Male; D011379:Prognosis; D012606:Scotland / Q000453:epidemiology; D015996:Survival Rate