Spermine induces haemoglobin synthesis in murine erythroleukaemia cells.
The naturally occurring polyamine spermine induces haemoglobin synthesis in murine erythroleukaemia (MEL) cells. Haemoglobin production was accompanied by accumulation of cytoplasmic beta-globin mRNA and growth inhibition, but not by cell-cycle block or changes in cell volume. Hexamethylene-bisacetamide (HMBA), a well known differentiating agent, also induces haemoglobin production, but causes a G1 block and decreases cell volume. These findings indicate that HMBA and spermine affect MEL cells differently, even though both induce haemoglobin production.
Delcros
J G
JG
Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94143, USA.
Schwartz
B
B
Clément
S
S
Basu
H S
HS
Marton
L J
LJ
Feuerstein
B G
BG
D000081:Acetamides / Q000494:pharmacology; D000818:Animals; D002453:Cell Cycle / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D048429:Cell Size / Q000187:drug effects; D004920:Erythropoiesis / Q000187:drug effects; D005914:Globins / Q000235:genetics; D006454:Hemoglobins / Q000096:biosynthesis*; D004915:Leukemia, Erythroblastic, Acute / Q000378:metabolism / Q000473:pathology; D051379:Mice; D011700:Putrescine / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics; D013095:Spermidine / Q000378:metabolism; D013096:Spermine / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D000081:Acetamides; D006454:Hemoglobins; D012333:RNA, Messenger; D013096:Spermine; D005914:Globins; C014026:hexamethylene bisacetamide; D013095:Spermidine; D011700:Putrescine