title: Sarcolemmal chloride and potassium channels from normal and myotonic mouse muscle studied in lipid supplemented vesicles.
abstract: By patch-clamp analysis of lipid supplemented vesicles prepared from the sarcolemma of mouse wildtype skeletal muscle, we could identify two known types of potassium channels, the inward rectifier and Ca2+ activated BK channels, and five types of chloride channels designated CIC-a, CIC-b, CIC-c, CIC-d, and CIC-e. CIC-b corresponds to a known chloride channel, whereas CICa, -c, -d and -e have not been described previously. The diversity may be due to a heterooligomeric composition of different subunits. None of these chloride channels nor the potassium channels were found in the sarcoplasmic reticulum fraction. In vesicles from myotonic mice, Clc-d and -e were not found.
authors.affiliation: Developmental Biology Unit, University of Bielefeld, FRG.
authors.forename: E
authors.initials: E
authors.lastname: Wischmeyer
authors.forename: S
authors.initials: S
authors.lastname: Weber-Schürholz
authors.forename: H
authors.initials: H
authors.lastname: Jockusch
mesh_terms: D000818:Animals; D018118:Chloride Channels / Q000737:chemistry / Q000502:physiology*; D004553:Electric Conductivity; D008081:Liposomes; D046911:Macromolecular Substances; D051379:Mice; D018482:Muscle, Skeletal / Q000648:ultrastructure*; D009222:Myotonia / Q000503:physiopathology*; D018408:Patch-Clamp Techniques; D015221:Potassium Channels / Q000737:chemistry / Q000502:physiology*; D012508:Sarcolemma / Q000502:physiology*
chemical_list: D018118:Chloride Channels; D008081:Liposomes; D046911:Macromolecular Substances; D015221:Potassium Channels