[Clinical study on effects of buyang huanwu decoction on coronary heart disease].
102 cases of coronary heart disease (CHD) were divided randomly into two groups, 70 cases were given orally the Buyang Huanwu Decoction (BYHWD) for 15 days and were compared with 32 control patients. The effect of BYHWD in treating angina pectoris and the change of EKG before and after the treatment were observed. The results were as follows: in BYHWD group the serum level of lipoperoxide (LPO), apolipoprotein (apo) B100, LPO/SOD (superoxide dismutase) and apo B100/apo A1 were lowered remarkably, the serum of SOD and apo A1 were elevated significantly (P < 0.01) comparing with the control group. The total effective rate of treating angina pectoris was 91.4%. But the difference was insignificant compared with the control group (P < 0.05). The EKG improvement rate was 85.7% in BYHWD group, the difference was very significant comparing with control group (P < 0.05). The results indicated that BYHWD had a good effect on removing the oxygen free radicals, reducing the injury of LPO and regulating the apolipoprotein metabolism in the patients with CHD. Therefore BYHWD is an effective TCM remedy for CHD.
Zhang
H
H
Guangzhou Hospital of TCM.
Liang
M J
MJ
Ma
Z X
ZX
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000789:Angina, Unstable / Q000097:blood / Q000188:drug therapy*; D016632:Apolipoprotein A-I / Q000097:blood; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B / Q000097:blood; D004365:Drugs, Chinese Herbal / Q000627:therapeutic use*; D005260:Female; D016166:Free Radical Scavengers / Q000627:therapeutic use; D006801:Humans; D008054:Lipid Peroxides / Q000097:blood; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood / Q000188:drug therapy; D013482:Superoxide Dismutase / Q000097:blood
D016632:Apolipoprotein A-I; D053299:Apolipoprotein B-100; D001055:Apolipoproteins B; D004365:Drugs, Chinese Herbal; D016166:Free Radical Scavengers; D008054:Lipid Peroxides; D013482:Superoxide Dismutase