title: A novel phorbol ester from Excoecaria agallocha.
abstract: The novel phorbol ester 12-deoxyphorbol 13-(3E,5E-decadienoate) [1] was isolated as the anti-HIV principle of Excoecaria agallocha leaves and stems collected in northwest Australia. The structure was determined by spectral means. Compound 1 was also a potent displacer of [3H]-phorbol dibutyrate from rat brain membranes.
authors.affiliation: Laboratory of Drug Discovery Research and Development, National Cancer Institute, NCI-FCRDC, Maryland 21702-1201, USA.
authors.forename: K L
authors.initials: KL
authors.lastname: Erickson
authors.forename: J A
authors.initials: JA
authors.lastname: Beutler
authors.forename: J H
authors.initials: JH
authors.lastname: Cardellina
authors.forename: J B
authors.initials: JB
authors.lastname: McMahon
authors.forename: D J
authors.initials: DJ
authors.lastname: Newman
authors.forename: M R
authors.initials: MR
authors.lastname: Boyd
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002853:Chromatography, Liquid; D015497:HIV-1 / Q000187:drug effects / Q000502:physiology; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry / Q000379:methods; D010703:Phorbol Esters / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D014779:Virus Replication / Q000187:drug effects
chemical_list: C094712:12-deoxyphorbol 13-(3,5-decadienoate); D000998:Antiviral Agents; D010703:Phorbol Esters