Sequential respiratory syncytial virus and cytomegalovirus pneumonia following bone marrow transplantation.
A 6-month-old child with familial hemophagocytic lymphohistiocytosis (FHL) experienced early sequential pneumonia due to respiratory syncytial virus (RSV) and cytomegalovirus (CMV) following bone marrow transplantation (BMT). The patient was deficient in natural killer (NK) cell activity (as found frequently in patients with FHL), and this risk factor may have played a major role in the concomitant infection by the two viral pathogens. Rapid diagnostic methods for both viruses are essential and early specific treatment may serve to ameliorate RSV- and CMV-induced lung injury in these life-threatening infections.
Kapelushnik
J
J
Department of Bone Marrow Transplantation, Hadassah University Hospital, Jerusalem, Israel.
Engelhard
D
D
Mehta
J
J
Or
R
R
Brandstetter
Y
Y
Picard
E
E
Cividalli
G
G
Nagler
A
A
D016026:Bone Marrow Transplantation; D003586:Cytomegalovirus Infections / Q000188:drug therapy / Q000209:etiology*; D005260:Female; D015616:Histiocytosis, Non-Langerhans-Cell / Q000628:therapy*; D006801:Humans; D007223:Infant; D008297:Male; D011024:Pneumonia, Viral / Q000188:drug therapy / Q000209:etiology*; D018357:Respiratory Syncytial Virus Infections / Q000209:etiology* / Q000628:therapy