Allelic variation of apolipoprotein E in Japanese sporadic Creutzfeldt-Jakob disease patients.
We analyzed apolipoprotein E (apo E) genotypes in 53 Japanese sporadic Creutzfeldt-Jakob disease (CJD) patients and 100 normal controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The apo E allelic frequencies in Japanese sporadic CJD patients and our control population were as follows: epsilon 2, 6.6% versus 7.5%; epsilon 3, 82.1% versus 81.5%; epsilon 4, 11.3% versus 11.0%. The mean ages at onset in Japanese sporadic CJD patients were as follows: epsilon 3/epsilon 3, 63.8 years; epsilon 3/epsilon 4, 66.3 years; epsilon 2/epsilon 3, 68.6 years. These results indicate that there is no association between apo E genotype and sporadic CJD in Japan.
Nakagawa
Y
Y
Department of Neuropathology, Kyushu University, Fukuoka, Japan.
Kitamoto
T
T
Furukawa
H
H
Ogomori
K
K
Tateishi
J
J
D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics*; D004586:Electrophoresis; D005838:Genotype; D006801:Humans; D007564:Japan; D016133:Polymerase Chain Reaction; D015995:Prevalence
D001057:Apolipoproteins E