Ectopic posterior pituitary tissue and paracentric inversion of the short arm of chromosome 1 in twins.
Twin boys with hypopituitarism, hypoplasia of the anterior pituitary gland. ectopic posterior pituitary tissue and paracentric inversion of the short arm of chromosome 1 are described. The smooth appearance at the base of the median eminence and the absence of a pituitary stalk at autopsy in these boys implies that the hypopituitarism resulted from a developmental aberration. It remains to be determined if there is a casual relationship between the chromosome 1 anomaly and hypopituitarism.
Siegel
S F
SF
Department of Pediatrics, Children's Hospital of Pittsburgh, University of Pittsburgh, PA, USA.
Ahdab-Barmada
M
M
Arslanian
S
S
Foley
T P
TP
D002828:Choristoma / Q000175:diagnosis / Q000235:genetics*; D002869:Chromosome Aberrations / Q000175:diagnosis; D025063:Chromosome Disorders; D007446:Chromosome Inversion; D002878:Chromosomes, Human, Pair 1; D004200:Diseases in Twins / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D007018:Hypopituitarism / Q000235:genetics* / Q000473:pathology; D007027:Hypothalamic Diseases / Q000175:diagnosis / Q000235:genetics; D007231:Infant, Newborn; D007621:Karyotyping; D008297:Male; D008473:Median Eminence; D010903:Pituitary Gland, Anterior / Q000473:pathology; D010904:Pituitary Gland, Posterior; D014430:Twins, Monozygotic