[Measurement and analysis of monophasic action potentials using fractally coated electrodes--II].
The monophasic action potential (MAP) represents a summed signal formed by overlapping action potentials of myocardial cells close to the tip of the lead. Analysis of the MAP therefore provides detailed information about the electrophysiological effects of autonomous nervous and pharmacological influences on the myocardium, for example adrenergic or cholinergic stimulation of the heart. All known MAP recordings were obtained with Ag/AgCl electrodes, which, thanks to their low polarization properties, ensure reliable MAP measurement. Owing to their toxicity and inadequate long-term stability, however, Ag/AgCl electrodes cannot be implanted. With the aim of making MAP measurement available for implantable devices, fractally coated leads were therefore developed. The aim of the present study was to evaluate the in vivo measurement of fractally coated leads which are characterized by negligible polarization, low impedance over a wide frequency range, high biocompatibility and good long-term stability. In addition, as a result of their extremely high Helmholtz capacities (up to 50 mF/cm2), fractally coated leads permit stimulation and virtually undisturbed recording of MAP with the same pair of electrodes. For the evaluation of MAP measurements with fractally coated leads, a quadrupolar catheter enabling simultaneous MAP recordings with 2 Ag/AgCl electrodes and 2 fractally coated leads was devised. The stimulation pulses were always applied via the fractally coated leads. With both types of electrode, with spontaneous excitation and stimulation, the well-known MAP morphology, with amplitudes of between 10 and 25 mV in the ventricle, and between 5 and 10 mV in the atrium, was seen.(ABSTRACT TRUNCATED AT 250 WORDS)
Wetzig
T
T
Zentralinstitut für Biomedizinische Technik, Universität Erlangen-Nürnbeg.
Fröhlich
R
R
Bolz
A
A
Göhl
K
K
Richter
P
P
Gottwik
M
M
Schaldach
M
M
D001285:Atropine / Q000494:pharmacology; D004562:Electrocardiography / Q000187:drug effects / Q000295:instrumentation*; D015716:Electrocardiography, Ambulatory / Q000187:drug effects / Q000295:instrumentation; D004567:Electrodes, Implanted; D004867:Equipment Design; D017709:Fractals; D006801:Humans; D007495:Iridium; D008422:Materials Testing; D009921:Metaproterenol / Q000494:pharmacology; D010138:Pacemaker, Artificial; D012815:Signal Processing, Computer-Assisted / Q000295:instrumentation; D012834:Silver; D018030:Silver Compounds; D013499:Surface Properties; D014025:Titanium
D018030:Silver Compounds; D012834:Silver; D007495:Iridium; D009921:Metaproterenol; D001285:Atropine; D014025:Titanium; C037548:silver chloride
Messung und Analyse monophasischer Aktionspotentiale mittels fraktal beschichteter Elektroden--Teil II.