Transcriptional control by the retinoblastoma protein.
The retinoblastoma gene product is an abundant nuclear protein whose 'pocket domain' mediates numerous protein-protein interactions. A substantial proportion of the RB-interacting proteins are transcription factors suggesting that RB plays a fundamental role in the regulation of transcription. Via these interactions, RB can influence both the progression through the cell cycle and the expression of lineage specific products. In this review I discuss some of the likely mechanisms by which RB regulates cell proliferation and differentiation.
Kouzarides
T
T
Wellcome/CRC Institute, Cambridge, UK.
D000818:Animals; D002454:Cell Differentiation; D002455:Cell Division; D051379:Mice; D016160:Retinoblastoma Protein / Q000737:chemistry / Q000502:physiology*; D014157:Transcription Factors / Q000378:metabolism; D014158:Transcription, Genetic
D016160:Retinoblastoma Protein; D014157:Transcription Factors