Effect of valproate and carbamazepine on visual evoked potentials in epileptic children.
The effects of carbamazepine (CBZ) and sodium valproate (SV) monotherapy on visual evoked potentials (VEP) were studied in 18 epileptic children receiving CBZ and nine epileptic children receiving SV. Pattern reversal VEP were determined before the administration of antiepileptic drugs (AED) and 1 year later during which time the patients had received AED. The VEP amplitude showed no consistent changes after 1 year of CBZ and SV therapy, but VEP P-100 latencies were significantly prolonged after 1 year of CBZ therapy. We conclude that CBZ causes a slowing down of central impulse conduction and that VEP is useful to evaluate the effects of AED within the central nervous system.
Yüksel
A
A
Department of Pediatric Neurology, Cerrahpaşa Faculty of Medicine, Istanbul University, Turkey.
Sarslan
O
O
Devranoğlu
K
K
Dirican
A
A
Hattat
N
N
Cenani
A
A
Yalçin
E
E
D002220:Carbamazepine / Q000494:pharmacology / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D004827:Epilepsy / Q000188:drug therapy* / Q000503:physiopathology; D005074:Evoked Potentials, Visual / Q000187:drug effects*; D005260:Female; D006801:Humans; D008297:Male; D009431:Neural Conduction / Q000187:drug effects; D014635:Valproic Acid / Q000494:pharmacology / Q000627:therapeutic use*; D014795:Visual Pathways / Q000187:drug effects / Q000503:physiopathology
D002220:Carbamazepine; D014635:Valproic Acid