title: Effect of D-400, a herbal formulation, on blood sugar of normal and alloxan-induced diabetic rats.
abstract: Blood sugar levels of normal rats treated with D-400 showed significant reduction (P < 0.05) as compared to control groups. The fall was seen at one month and remained so uptill 3 months. Hyperglycemic response to adrenaline was significantly lowered (P < 0.05) following D-400 treatment. D-400 potentiated the hypoglycemia following tolbutamide treatment. Blood sugar remained persistently low in tolbutamide plus D-400 treated group after 3 and 4 hours (P < 0.05). In the alloxan-induced diabetic rats, a significant lowering of blood and urinary sugar was noticed on day 20, 30 and 40 following treatment with D-400 (P < 0.05). Liver glycogen depletion was significantly inhibited in the D-400 treated group (P < 0.025). D-400 has significantly potentiated (P < 0.05) the hypoglycemic action of insulin in alloxan-induced diabetic rats.
authors.affiliation: R & D Centre, Himalaya Drug Co., Bangalore.
authors.forename: S D
authors.initials: SD
authors.lastname: Anturlikar
authors.forename: S
authors.initials: S
authors.lastname: Gopumadhavan
authors.forename: B L
authors.initials: BL
authors.lastname: Chauhan
authors.forename: S K
authors.initials: SK
authors.lastname: Mitra
mesh_terms: D000496:Alloxan / Q000633:toxicity; D000818:Animals; D001786:Blood Glucose / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D001835:Body Weight / Q000187:drug effects; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy* / Q000503:physiopathology; D004837:Epinephrine / Q000633:toxicity; D005215:Fasting; D005260:Female; D006003:Glycogen / Q000378:metabolism; D006029:Glycosuria / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D008517:Phytotherapy; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D014044:Tolbutamide / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D001786:Blood Glucose; C095293:D 400; D010936:Plant Extracts; D000496:Alloxan; D006003:Glycogen; D014044:Tolbutamide; D004837:Epinephrine