title: Predictive value of MR imaging-dependent and non-MR imaging-dependent parameters for recurrence of laryngeal cancer after radiation therapy.
abstract: OBJECTIVE
  To determine the predictive value of several clinical and radiologic parameters for recurrence of laryngeal cancer.
  
  
  METHODS
  Eighty previously untreated patients underwent magnetic resonance (MR) imaging before radiation therapy with curative intent. Tumor volume was calculated from T1-weighted MR images. Cartilage was considered invaded by pathologic tissue if it had intermediate signal intensity on T1-weighted spin-echo (SE) MR images and high signal intensity on T2-weighted SE MR images. The minimum follow-up was 2 years.
  
  
  RESULTS
  Parameters such as age, sex, histopathologic findings, and invasion of the vocal muscle or pre-epiglottic space were not significantly correlated with tumor recurrence. Logistic regression analysis showed three relevant contributors: cord mobility, as judged clinically, and tumor volume and, more significantly, cartilage invasion, as seen at MR imaging.
  
  
  CONCLUSIONS
  For untreated laryngeal cancer, MR imaging findings of tumor volume and cartilage invasion allow better patient selection for either radiation therapy or surgery. MR imaging is mandatory for T staging of laryngeal cancer.
authors.affiliation: Department of Radiology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: J A
authors.initials: JA
authors.lastname: Castelijns
authors.forename: M W
authors.initials: MW
authors.lastname: van den Brekel
authors.forename: E M
authors.initials: EM
authors.lastname: Smit
authors.forename: H
authors.initials: H
authors.lastname: Tobi
authors.forename: F W
authors.initials: FW
authors.lastname: van Wagtendonk
authors.forename: R P
authors.initials: RP
authors.lastname: Golding
authors.forename: H W
authors.initials: HW
authors.lastname: Venema
authors.forename: C
authors.initials: C
authors.lastname: van Schaik
authors.forename: G B
authors.initials: GB
authors.lastname: Snow
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D002294:Carcinoma, Squamous Cell / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy*; D004825:Epiglottis / Q000473:pathology; D005260:Female; D005500:Follow-Up Studies; D005544:Forecasting; D006801:Humans; D007817:Laryngeal Cartilages / Q000473:pathology; D007822:Laryngeal Neoplasms / Q000175:diagnosis* / Q000473:pathology / Q000532:radiotherapy*; D016015:Logistic Models; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009361:Neoplasm Invasiveness; D009364:Neoplasm Recurrence, Local / Q000175:diagnosis*; D009367:Neoplasm Staging; D018579:Patient Selection; D011879:Radiotherapy Dosage; D012737:Sex Factors; D014827:Vocal Cords / Q000473:pathology