Acute administration of alpha-methyl-para-tyrosine alters levels of norepinephrine transporter mRNA in the rat brainstem.
This study investigated whether rat norepinephrine transporter (NET) mRNA levels would be altered by alpha-methyl-p-tyrosine (alpha-MPT), a tyrosine hydroxylase inhibitor. While NE levels decreased at 1 and 3 days but recovered at 7 days after alpha-MPT, NET mRNA levels decreased at 3 and 7 days but not at 1 day after alpha-MPT. The results indicate that acute treatment with alpha-MPT led to a delayed time response in its effects on NET mRNA and NE levels in the rat brain.
Xiao
Q
Q
Department of Psychiatry, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
Yao
Y
Y
Tejani-Butt
S M
SM
D000199:Actins; D000818:Animals; D001933:Brain Stem / Q000187:drug effects / Q000378:metabolism*; D002352:Carrier Proteins / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D007274:Injections, Intraperitoneal; D008297:Male; D008781:Methyltyrosines / Q000494:pharmacology*; D009638:Norepinephrine / Q000235:genetics / Q000378:metabolism*; D050484:Norepinephrine Plasma Membrane Transport Proteins; D016133:Polymerase Chain Reaction; D012333:RNA, Messenger / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D027981:Symporters
D000199:Actins; D002352:Carrier Proteins; D008781:Methyltyrosines; D050484:Norepinephrine Plasma Membrane Transport Proteins; D012333:RNA, Messenger; C493226:Slc6a2 protein, rat; D027981:Symporters; D009638:Norepinephrine