Fusacandins A and B; novel antifungal antibiotics of the papulacandin class from Fusarium sambucinum. II. Isolation and structural elucidation.
Two novel antifungal compounds of the papulacandin class, named fusacandins A and B, have been isolated from Fusarium sambucinum. Each compound contains two units of galactose and one of glucose, the latter connected as a C-glycoside to an aromatic moiety. Fusacandin A is esterified at two sites with long-chain, unsaturated fatty acids and fusacandin B at only one site. The structures of the fusacandins were elucidated through analysis of mass spectral and 1-D and 2-D homonuclear and heteronuclear NMR data.
Hochlowski
J E
JE
Abbott Laboratories, Abbott Park, Illinois 60064, USA.
Whittern
D N
DN
Buko
A
A
Alder
L
L
McAlpine
J B
JB
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification*; D005231:Fatty Acids, Unsaturated / Q000737:chemistry / Q000302:isolation & purification; D005670:Fusarium; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D009844:Oligosaccharides / Q000737:chemistry / Q000302:isolation & purification
D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D009844:Oligosaccharides; C095339:fusacandin A; C095340:fusacandin B