title: Efficacy of recombinant bovine interleukin-2 as an adjunct to dry cow therapy.
abstract: Recombinant bovine interleukin-2 was tested as adjunct therapy to intramammary infusion of antibiotics at drying off. Cows were assigned randomly within three commercial herds to either recombinant bovine interleukin-2 or PBS treatment groups at drying off. Ninety-five cows received intramammary infusions of 1 mg of recombinant bovine interleukin-2 in each quarter immediately preceding intramammary infusion of a product for antibiotic therapy of dry cows. Ninety-four cows received intramammary infusion of 10 ml of endotoxin-free PBS in each quarter immediately preceding the antibiotic therapy. Cure rates for IMI present at drying off did not differ between cows treated with recombinant bovine interleukin-2 and those treated with PBS. Intramammary infusion of recombinant bovine interleukin-2 did not affect the rate of new IMI during the dry period. Milk production and SCC during the first 3 mo of lactation subsequent to therapy did not differ between treatment groups. Intramammary infusion of recombinant bovine interleukin-2 was not effective as an adjunct to antibiotic therapy for dry cows.
authors.affiliation: Department of Dairy Science, Ohio State University, Ohio Agricultural Research and Development Center, Wooster 44691, USA.
authors.forename: J S
authors.initials: JS
authors.lastname: Hogan
authors.forename: K L
authors.initials: KL
authors.lastname: Smith
authors.forename: D A
authors.initials: DA
authors.lastname: Todhunter
authors.forename: P S
authors.initials: PS
authors.lastname: Schoenberger
authors.forename: D
authors.initials: D
authors.lastname: Shuster
mesh_terms: D000818:Animals; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002417:Cattle; D007376:Interleukin-2 / Q000008:administration & dosage / Q000627:therapeutic use*; D008321:Mammary Glands, Animal; D008414:Mastitis, Bovine / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000627:therapeutic use; D013203:Staphylococcal Infections / Q000188:drug therapy*
chemical_list: D000900:Anti-Bacterial Agents; D007376:Interleukin-2; D011994:Recombinant Proteins