title: HER-2 oncogene is not amplified in primary carcinoma of the fallopian tube. Austrian Cooperative Study Group for Fallopian Tube Carcinoma.
abstract: 73 women suffering from primary carcinoma of the fallopian tube underwent surgical excision of their tubes. The tissue was embedded in paraffin and investigated for HER-2 oncogene amplification with a quantitative polymerase chain reaction method. DNA could be extracted and successfully prepared in 65/73 samples. None of the tissue samples exhibited amplified the HER-2 oncogene. Data suggest that the HER-2 oncogene does not play a role in tumor transformation and progression in fallopian tube carcinomas. This contrasts with observations in ovarian carcinomas, with which fallopian tube carcinomas share many clinical, histological and biochemical similarities.
authors.affiliation: Ludwig Boltzmann Institute for Experimental Endocrinology, Department of Cellular Endocrinology, AKH Vienna, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Stühlinger
authors.forename: A C
authors.initials: AC
authors.lastname: Rosen
authors.forename: K
authors.initials: K
authors.lastname: Dobianer
authors.forename: C
authors.initials: C
authors.lastname: Hruza
authors.forename: H
authors.initials: H
authors.lastname: Helmer
authors.forename: M
authors.initials: M
authors.lastname: Kein
authors.forename: T
authors.initials: T
authors.lastname: Koukal
authors.forename: A
authors.initials: A
authors.lastname: Reiner
authors.forename: M
authors.initials: M
authors.lastname: Klein
authors.forename: J
authors.initials: J
authors.lastname: Spona
mesh_terms: D001483:Base Sequence; D005185:Fallopian Tube Neoplasms / Q000235:genetics*; D005260:Female; D006801:Humans; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000235:genetics*; D011960:Receptors, Estrogen / Q000235:genetics; D011980:Receptors, Progesterone / Q000235:genetics; D015203:Reproducibility of Results; D012189:Retrospective Studies
chemical_list: D018719:Erb-b2 Receptor Tyrosine Kinases; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone