Plasma platinum elimination in a hemodialysis patient treated with cisplatin.
The pharmacokinetics of intravenously administrated cisplatin (CDDP) were studied in a patient with meduloblastoma receiving regular hemodialysis for chronic renal failure. The patient received four CDDP infusions of 25 mg/m2 in two courses and underwent hemodialysis before each treatment and in intervals of 48 h thereafter with blood sampling at the beginning and the end of each hemodialysis. The data obtained were compared with the pharmacokinetic data from follow-up studies of 19 CDDP treatments in 15 patients suffering from various malignancies with no renal failure where a biexponential pharmacokinetic curve was recorded. The data of platinum (Pt) elimination of the patient receiving hemodialysis resembled the curve of those who had not, but following the second CDDP treatment in each course the peak Pt level in plasma was doubled, with a somewhat slower rate of elimination.
Gorodetsky
R
R
Sharett Institute of Oncology, Hadassah University Hospital, Jerusalem, Israel.
Vexler
A
A
Bar-Khaim
Y
Y
Biran
H
H
D000328:Adult; D002945:Cisplatin / Q000378:metabolism / Q000493:pharmacokinetics*; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D010984:Platinum / Q000097:blood* / Q000378:metabolism; D006435:Renal Dialysis; D051437:Renal Insufficiency / Q000628:therapy; D013997:Time Factors
D010984:Platinum; D002945:Cisplatin