MRI of the brain in Wilson disease: T2 signal loss under therapy.
Repeat examinations in a de novo patient with Wilson disease revealed an expansion of decreased signal intensities in the basal ganglia on T2-weighted imaging after initiation of copper trapping therapy. Since marked clinical improvement was associated with continued urinary copper excretion, iron depositioning in exchange for copper might explain these findings.
Engelbrecht
V
V
Institute of Diagnostic Radiology, Heinrich-Heine University of Düsseldorf, Germany.
Schlaug
G
G
Hefter
H
H
Kahn
T
T
Mödder
U
U
D000328:Adult; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D005500:Follow-Up Studies; D006527:Hepatolenticular Degeneration / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use; D013997:Time Factors
D010396:Penicillamine