title: [Hepatitis C virus antibodies in alcoholic patients].
abstract: It has been reported that chronic alcoholics show a high prevalence of hepatitis C virus (HCV) infection, with a possible role in the pathogenesis and severity of underlying liver disease. Thus, the present study was aimed to evaluate the prevalence of HCV antibodies (anti HCV-Ab) in a group of patients admitted to an Internal Medicine Department, as well as to compare characteristics of anti-HCV-Ab(+ve) respect to anti-HCV(-ve) patients. The presence of anti-HCV-Ab was prospectively studied in 180 alcoholic patients admitted during a 16-month period using a second generation ELISA. Intravenous drug abusers were excluded. Reasons for admittance were as follows: alcohol withdrawal syndrome (92 cases), complications of liver cirrhosis (mainly ascites) (54 cases), acute pancreatitis (12 cases) and miscellaneous causes (22 cases). Sixty-six patients were cirrhotics, 23 had fatty liver, 27 had liver fibrosis and 28 alcoholic hepatitis (36 patients were not evaluable concerning liver lesion). Twelve patients (6.7%) were anti-HCV-Ab(+ve). Prevalence was higher in patients admitted because of complications of cirrhosis (16.7%) than that of those admitted due to alcohol abstinence syndrome (1.1%, p < 0.01). Likewise, the proportion of HVC-Ab(+ve) patients was higher in patients with liver cirrhosis (16.7%) respect to those with lesser degrees of liver injury (1.3%; p < 0.01). In the latter group, the prevalence of anti-HCV-Ab(+ve) was similar to that of the normal population. Anti-HCV-Ab patients were older than anti-HCV-Ab(-ve) cases.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Departamento de Medicina Interna, Hospital General de Galicia, Facultad de Medicina, Universidad de Santiago de Compostela.
authors.forename: A
authors.initials: A
authors.lastname: González Quintela
authors.forename: R
authors.initials: R
authors.lastname: Alende
authors.forename: A
authors.initials: A
authors.lastname: Aguilera
authors.forename: S
authors.initials: S
authors.lastname: Tomé
authors.forename: F
authors.initials: F
authors.lastname: Gude
authors.forename: E
authors.initials: E
authors.lastname: Pérez Becerra
authors.forename: A
authors.initials: A
authors.lastname: Torre
authors.forename: J M
authors.initials: JM
authors.lastname: Martínez Vázquez
authors.forename: E
authors.initials: E
authors.lastname: Barrio
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D000437:Alcoholism / Q000150:complications*; D003430:Cross-Sectional Studies; D004797:Enzyme-Linked Immunosorbent Assay; D005235:Fatty Liver, Alcoholic / Q000150:complications; D005260:Female; D016174:Hepacivirus / Q000276:immunology*; D006508:Hepatitis Antibodies / Q000032:analysis*; D006526:Hepatitis C / Q000453:epidemiology*; D006519:Hepatitis, Alcoholic / Q000150:complications; D006801:Humans; D008103:Liver Cirrhosis / Q000150:complications; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D012737:Sex Factors
chemical_list: D006508:Hepatitis Antibodies
vernacular_title: Anticuerpos frente al virus C de la hepatitis en alcohólicos activos.