Synthesis and evaluation of aminoadamantane derivatives for in vitro anti-HIV and antitumor activities.
The synthesis of a series of 2-aminobenzimidazole and indole amide derivatives containing the adamantyl moiety is described. The compounds, evaluated for in vitro anti-HIV and antitumor activities, were found to be moderately active or inactive, versus drug-treated controls, used for comparison purposes.
da Settimo
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Dipartimento di Scienze Farmaceutiche, Università di Pisa.
Marini
A M
AM
Primofiore
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G
Da Settimo
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F
D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D006678:HIV / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001562:Benzimidazoles; C027391:2-aminobenzimidazole; D000218:Adamantane