Peptidergic mechanisms in feeding behaviour.
Hyperphagia was induced in mice by p.o. administration of different types of CNS depressant drugs, like chlordiazepoxide 25 mg/kg diazepam 2.5 mg/kg, cyproheptadine 2 mg/kg and phenobarbitone 25 mg/kg. Such hyperphagia was abolished by pretreatment with naloxone 0.1 mg/kg sc. Naloxone per se at this dose produced no significant effect on the food intake. This is suggestive of the role of peptidergic mechanisms in the feeding behaviour in mice.
Dua
P R
PR
Central Drug Research Institute, Lucknow.
Sharma
V L
VL
D000818:Animals; D014151:Anti-Anxiety Agents / Q000633:toxicity; D002492:Central Nervous System Depressants / Q000008:administration & dosage / Q000633:toxicity*; D002707:Chlordiazepoxide / Q000008:administration & dosage / Q000633:toxicity; D003533:Cyproheptadine / Q000008:administration & dosage / Q000633:toxicity; D003975:Diazepam / Q000008:administration & dosage / Q000633:toxicity; D004435:Eating / Q000187:drug effects*; D005247:Feeding Behavior / Q000187:drug effects*; D005260:Female; D006633:Histamine Antagonists / Q000633:toxicity; D006993:Hypnotics and Sedatives / Q000633:toxicity; D008297:Male; D051379:Mice; D009270:Naloxone / Q000008:administration & dosage / Q000494:pharmacology; D010634:Phenobarbital / Q000008:administration & dosage / Q000633:toxicity; D001615:beta-Endorphin / Q000502:physiology
D014151:Anti-Anxiety Agents; D002492:Central Nervous System Depressants; D006633:Histamine Antagonists; D006993:Hypnotics and Sedatives; D003533:Cyproheptadine; D009270:Naloxone; D001615:beta-Endorphin; D002707:Chlordiazepoxide; D003975:Diazepam; D010634:Phenobarbital