title: [Treatment of metastatic malignant insulinomas. 2 cases].
abstract: Malignant insulinomas are slow growing tumours for which the prognosis is worsened by metastatic disease and sequellae of excess hormone secretion. Management of unresectable tumours includes intravenous chemotherapy and local treatments such as palliative surgery and transcatheter arterial embolization of liver metastases. Long-term survival can also be improved by inhibition of secretory products of the tumour with either octreotide, a somatostatin analogue, or diazoxide. We report two cases of malignant insulinomas with liver metastases for which objective responses were obtained with combination of local treatment and intravenous chemotherapy.
authors.affiliation: Département de Médecine, Institut Gustave Roussy, Villejuif.
authors.forename: L
authors.initials: L
authors.lastname: Mounedji-Boudiaf
authors.forename: P
authors.initials: P
authors.lastname: Rougier
authors.forename: S
authors.initials: S
authors.lastname: Culine
authors.forename: T
authors.initials: T
authors.lastname: de Baere
authors.forename: P
authors.initials: P
authors.lastname: Lasser
authors.forename: B
authors.initials: B
authors.lastname: Escudier
authors.forename: M
authors.initials: M
authors.lastname: Ducreux
authors.forename: E
authors.initials: E
authors.lastname: Kaloustian
authors.forename: J P
authors.initials: JP
authors.lastname: Droz
authors.forename: A
authors.initials: A
authors.lastname: Roche
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004621:Embolization, Therapeutic / Q000379:methods*; D006801:Humans; D007340:Insulinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D008113:Liver Neoplasms / Q000556:secondary / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010190:Pancreatic Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D012074:Remission Induction
vernacular_title: Traitement des insulinomes malins métastatiques. Deux observations.