Polymorphic paracetamol conjugation: phenotyping in a Hungarian population.
The authors studied the distribution of the paracetamol conjugation in a Hungarian population (53 adult Caucasian persons). The data indicated that the excretion of paracetamol glucuronide and sulphate were not normally distributed. Bimodality were apparent in both conjugation pathways: 15.1% of subjects was relatively extensive glucuronidators, and the 24.5% of subjects was extensive sulphatators. Monitoring the ratios of various urinary paracetamol conjugates/paracetamol may be useful as a tool for determining the glucuronide and sulphate conjugation capacity in humans.
Róna
K
K
Haynal Imre University of Health Sciences, Ist Department of Medicine, Budapest, Hungary.
Ary
K
K
Szüts
I
I
Kovács
L
L
Gachályi
B
B
D000082:Acetaminophen / Q000493:pharmacokinetics*; D000284:Administration, Oral; D000328:Adult; D000367:Age Factors; D002853:Chromatography, Liquid; D005260:Female; D005965:Glucuronates / Q000652:urine*; D006801:Humans; D006814:Hungary; D008297:Male; D010641:Phenotype; D013431:Sulfates / Q000652:urine*
D005965:Glucuronates; D013431:Sulfates; D000082:Acetaminophen