[Use of siflox (ciprofloxacin) in paratrachoma and assessment of its effectiveness by immunoenzyme analysis].
The possibility of using an antibiotic ciprofloxacin quinolone (siflox) in combined therapy of paratrachoma was investigated. Fifty patients with acute and subacute paratrachoma were included in the study. The drug efficacy was assessed by clinical results and laboratory findings: by the time course of the levels of Chlamydia trachomatis antigen in smears from the conjunctiva, measured by enzyme immunoassay (EIA) using the Abbott kit. The results indicated a high efficacy of siflox in combination with local application of tetracycline ointment; such treatment helped shorten the treatment period. EIA proved to be not only a highly sensitive and effective method for the diagnosis of chlamydial infection of the eyes, but permitted assessment of changes in the levels of the antigen over the course of treatment and, hence, helped assess the treatment efficacy.
Maĭchuk
Iu F
IuF
Andzhelov
V O
VO
Krichevskaia
G I
GI
Vakhova
E S
ES
D000328:Adult; D000942:Antigens, Bacterial / Q000032:analysis; D002692:Chlamydia trachomatis / Q000276:immunology; D002939:Ciprofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D003235:Conjunctivitis, Inclusion / Q000175:diagnosis / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D009824:Ointments; D013752:Tetracycline / Q000008:administration & dosage
D000942:Antigens, Bacterial; D009824:Ointments; D002939:Ciprofloxacin; D013752:Tetracycline
Primenenie preparata sifloksa (tsiprofloksatsina) pri paratrakhome i otsenka ego éffektivnosti metodom immunofermentnogo analiza.