[Relationship between various syndrome-types and defect of erythrocyte insulin receptors in non-insulin dependent diabetes mellitus].
Fifty-seven patients of non-insulin dependent diabetes mellitus (NIDDM) were divided into various groups by Syndrome Differentiation in TCM and 18 cases of non-diabetes mellitus were taken as control. The relationship of Syndrome-types and defect of the erythrocyte insulin receptors were studied with the percentage of specific insulin binding to erythrocyte, number and average affinity of erythrocyte insulin receptors. The results showed: (1) The patients of NIDDM had defect of erythrocyte insulin receptors specified with decreased number of insulin receptors; (2)Mild defect of erythrocyte insulin receptors was found in Syndrome of Yin Deficiency and hyperactivity of Heat, but serious defect in the Syndrome of both Qi and Yin Deficiency, in the Syndrome of both Yin and Yang Deficiency. Above data suggested that the defect of erythrocyte insulin receptors was correlated with Syndrome-types of patients with NIDDM, the more serious Deficiency Syndrome, the more serious defect of erythrocyte insulin receptors.
Zhu
Z Z
ZZ
First Affiliated Hospital, Guangzhou University of TCM.
Xiong
M Q
MQ
D000368:Aged; D001665:Binding Sites; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism*; D003937:Diagnosis, Differential; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006801:Humans; D007333:Insulin Resistance; D008297:Male; D008516:Medicine, Chinese Traditional; D008875:Middle Aged; D011972:Receptor, Insulin / Q000378:metabolism*
D011972:Receptor, Insulin