The involvement of the peripheral 5-HT2A receptor in peripherally administered serotonin-induced hyperglycemia in rats.
The mechanism of the hyperglycemic response to intraperitoneally administered serotonin (5-HT) was studied in rats. 5-HT i.p.-induced hyperglycemia was strongly antagonized by the 5-HT2A receptor antagonist ketanserin. 5-HT did not affect the serum insulin levels and increased plasma glucagon levels only at the high dose of 10 mg/kg. 5-HT dose-dependently induced a remarkable increase in plasma adrenaline levels and these effects were antagonized by ketanserin. 5-HT-induced hyperglycemia was abolished by adrenodemedullation. These results suggest that the hyperglycemic effects of 5-HT are closely related to the release of adrenaline from the adrenal gland, mediated by 5-HT2A receptors.
Yamada
J
J
Department of Pharmacology, Kobe Pharmaceutical University, Motoyamakita-Machi, Kobe, Japan.
Sugimoto
Y
Y
Yoshikawa
T
T
Kimura
I
I
Horisaka
K
K
D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D004837:Epinephrine / Q000097:blood; D006943:Hyperglycemia / Q000139:chemically induced / Q000378:metabolism*; D007650:Ketanserin / Q000494:pharmacology; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D011985:Receptors, Serotonin / Q000378:metabolism*; D012701:Serotonin / Q000494:pharmacology*
D001786:Blood Glucose; D011985:Receptors, Serotonin; D012701:Serotonin; D007650:Ketanserin; D004837:Epinephrine