title: Pfcrk-1, a developmentally regulated cdc2-related protein kinase of Plasmodium falciparum.
abstract: A gene encoding a novel cdc2-related protein kinase has been identified in Plasmodium falciparum, using degenerate oligonucleotides designed to hybridise to regions that are conserved in members of the cdc2 gene family. This gene, called Pfcrk-1, is located on chromosome 4. It is most closely related to the p58GTA gene family, members of which are negative regulators of cell growth in vertebrates. Pfcrk-1 is developmentally regulated, as indicated by stage-specific accumulation of mRNA in gametocytes.
authors.affiliation: Institute of Cell, Animal and Population Biology, University of Edinburgh, UK.
authors.forename: C
authors.initials: C
authors.lastname: Doerig
authors.forename: C
authors.initials: C
authors.lastname: Doerig
authors.forename: P
authors.initials: P
authors.lastname: Horrocks
authors.forename: J
authors.initials: J
authors.lastname: Coyle
authors.forename: J
authors.initials: J
authors.lastname: Carlton
authors.forename: A
authors.initials: A
authors.lastname: Sultan
authors.forename: D
authors.initials: D
authors.lastname: Arnot
authors.forename: R
authors.initials: R
authors.lastname: Carter
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D016203:CDC2 Protein Kinase / Q000096:biosynthesis / Q000235:genetics* / Q000302:isolation & purification; D002453:Cell Cycle; D002874:Chromosome Mapping; D016521:Electrophoresis, Gel, Pulsed-Field; D004790:Enzyme Induction; D005260:Female; D018507:Gene Expression Regulation, Developmental; D008297:Male; D008969:Molecular Sequence Data; D005810:Multigene Family; D010963:Plasmodium falciparum / Q000201:enzymology* / Q000235:genetics / Q000254:growth & development; D015800:Protozoan Proteins / Q000096:biosynthesis / Q000235:genetics* / Q000302:isolation & purification; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D016053:RNA, Protozoan / Q000096:biosynthesis / Q000235:genetics; D016415:Sequence Alignment; D017385:Sequence Homology; D017386:Sequence Homology, Amino Acid
chemical_list: D015800:Protozoan Proteins; D012333:RNA, Messenger; D016053:RNA, Protozoan; D016203:CDC2 Protein Kinase; C095051:Pfcrk-1 protein, Plasmodium falciparum