Mouse protection induced by Pseudomonas aeruginosa PAC1R and its defective mutants, Salmonella minnesota Re-mutant and Escherichia coli O14.
Pseudomonas aeruginosa PAC1R and its defective mutants (acetone-killed bacteria), Salmonella minnesota Re mutant (acetone-killed bacteria and Re-LPS) and Escherichia coli O14 (acetone-killed bacteria and enterobacterial common antigen, ECA) were studied in a mouse active protection test. Immunized mice were challenged with wild-type P. aeruginosa strains. It was established that P. aeruginosa LPS-defective mutants induced cross-immunity against different Fisher immunotypes of P. aeruginosa. S. minnesota Re-LPS and ECA gave mice protection against P. aeruginosa.
Stanislavsky
E S
ES
II. Mechnicov Research Institute for Vaccine and Sera, Russian Academy of Medical Sciences, Moscow.
Kholodkova
E V
EV
Makarenko
T A
TA
Sukhachevskaya
M V
MV
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D001428:Bacterial Vaccines; D004756:Enterobacteriaceae Infections / Q000276:immunology* / Q000517:prevention & control; D004926:Escherichia coli / Q000276:immunology*; D005260:Female; D008297:Male; D051379:Mice; D011550:Pseudomonas aeruginosa; D012475:Salmonella / Q000235:genetics / Q000276:immunology*; D014611:Vaccination
D000907:Antibodies, Bacterial; D001428:Bacterial Vaccines