Study of the optimum time for human chorionic gonadotropin-ovum pickup interval in in vitro fertilization.
OBJECTIVE
To study the optimum time for ovum pickup after human chorionic gonadotropin (hCG) injection in in vitro fertilization.


METHODS
Prospective randomized study.


METHODS
The Egyptian IVF-ET center.


METHODS
Ninety couples with male factor infertility enrolled for intracytoplasmic sperm injection, divided into three groups. Ovum pickup was performed at 35 hr (group A), 36 hr (group B), and 37 hr (group C) after hCG injection.


RESULTS
Number of metaphase II oocytes was significantly higher in group B compared to group A. There was no significant difference between group B and C. Fertilization rate was equal in all groups. The number of fertilized oocytes was significantly higher in group B as compared to group A, and there was no significant difference between groups B and C.


CONCLUSIONS
Oocyte maturity in gonadotropin releasing hormone analogue agonist/human menopausal gonadotropin stimulated cycles is attained 36 hr after hCG injection. Oocyte retrieval should not be performed before 36 hr, and there is no risk of spontaneous ovulation between 36 and 37 hr.
Mansour
R T
RT
Egyptian IVF-ET Center, Maadi, Cairo.
Aboulghar
M A
MA
Serour
G I
GI
D000328:Adult; D006063:Chorionic Gonadotropin / Q000494:pharmacology*; D005260:Female; D005307:Fertilization in Vitro / Q000379:methods / Q000592:standards*; D006801:Humans; D008677:Metaphase; D009865:Oocytes / Q000166:cytology / Q000502:physiology; D010060:Ovulation / Q000187:drug effects* / Q000502:physiology; D011446:Prospective Studies; D013997:Time Factors
D006063:Chorionic Gonadotropin