Lipases and lecithin: cholesterol acyltransferase in the control of lipoprotein metabolism.
Lipoprotein lipase, hepatic lipase, and lecithin: cholesterol acyltransferase have coordinated enzymatic roles in lipoprotein metabolism. New evidence suggests that the lipases are multifunctional proteins that are able to mediate lipoprotein binding and uptake. The importance of all three enzymes in the control of lipoprotein metabolism can be explored in the future by using the newly generated transgenic animals.
Applebaum-Bowden
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Department of Internal Medicine, Bowman Gray School of Medicine of Wake Forest University, Winston-Salem, North Carolina, USA.
D000818:Animals; D002914:Chylomicrons / Q000378:metabolism; D006801:Humans; D008049:Lipase / Q000096:biosynthesis / Q000502:physiology*; D008074:Lipoproteins / Q000378:metabolism*; D008075:Lipoproteins, HDL / Q000378:metabolism; D008099:Liver / Q000201:enzymology; D007862:Phosphatidylcholine-Sterol O-Acyltransferase / Q000096:biosynthesis / Q000502:physiology*
D002914:Chylomicrons; D008074:Lipoproteins; D008075:Lipoproteins, HDL; D007862:Phosphatidylcholine-Sterol O-Acyltransferase; D008049:Lipase