Animal experimental myelography in the pig. A comparison between iohexol and iotrolan.
OBJECTIVE
The authors compared the effects of a nonionic monomeric, iohexol (Omnipaque, 300 mg I/ml), and a nonionic dimeric, iotrolan (Isovist, 300 mg I/ml), contrast medium in the spinal subarachnoid space of the pig.


METHODS
Lumbar and lateral C1-C2 punctures were performed in 10 pigs. Ten milliliters iohexol or iotrolan were injected via the lumbar needle. Blood pressure, electrocardiogram, intravesical pressure, and cerebrospinal fluid pressure were recorded during the injections and at intervals for 4 to 5 hours after the injections. Blood samples were taken at 30, 60, 120, 180, 240, and 300 minutes after the injections and analyzed for iodine concentration.


RESULTS
No changes were seen during the injections, and there were no differences in the blood pressure, cerebrospinal fluid pressure, electrocardiographic recordings, or in the plasma iodine concentrations during the first 4 to 5 hours after the injections. Short-lasting, rhythmic bladder contractions were seen during some injections with both iohexol and iotrolan.


CONCLUSIONS
Both iohexol and iotrolan were well tolerated, and there was no significant difference between them. and there was no significant difference between them.
Skalpe
I O
IO
Institute of Surgical Research, National Hospital (Rikshospitalet), Oslo, Norway.
Tang
G J
GJ
D000818:Animals; D001794:Blood Pressure / Q000187:drug effects; D015170:Cerebrospinal Fluid Pressure / Q000187:drug effects; D003287:Contrast Media / Q000494:pharmacology; D004562:Electrocardiography / Q000187:drug effects; D005260:Female; D007472:Iohexol / Q000494:pharmacology; D008297:Male; D009192:Myelography / Q000379:methods*; D013129:Spinal Puncture; D013552:Swine; D014283:Triiodobenzoic Acids / Q000494:pharmacology; D001743:Urinary Bladder / Q000187:drug effects
D003287:Contrast Media; D014283:Triiodobenzoic Acids; C033300:iotrolan; D007472:Iohexol