Genetic changes in the population of Plasmodium falciparum in a Sudanese village over a three-year period.
The prevalence of alleles of genes of the Plasmodium falciparum population of Asar village in eastern Sudan was monitored over three consecutive years. The characters studied were parasite surface antigens, proteins detected by two-dimensional polyacrylamide gel electrophoresis, enzymes, and drug response. Fluctuations in allele prevalences from one year to another were detected and are discussed in the context of seasonality of malaria transmission in the region studied.
Babiker
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HA
Institute of Cell, Animal and Population Biology, University of Edinburgh, United Kingdom.
Satti
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G
Walliker
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D
D000483:Alleles; D000619:Aminohydrolases / Q000032:analysis / Q000235:genetics; D000818:Animals; D000953:Antigens, Protozoan / Q000032:analysis / Q000235:genetics; D000954:Antigens, Surface / Q000032:analysis / Q000235:genetics; D002738:Chloroquine / Q000494:pharmacology; D015180:Electrophoresis, Gel, Two-Dimensional; D010450:Endopeptidases / Q000032:analysis / Q000235:genetics; D005787:Gene Frequency; D017125:Genes, Protozoan / Q000235:genetics; D014644:Genetic Variation; D005956:Glucose-6-Phosphate Isomerase / Q000032:analysis / Q000235:genetics; D006801:Humans; D016778:Malaria, Falciparum / Q000453:epidemiology / Q000469:parasitology / Q000635:transmission*; D020066:Merozoite Surface Protein 1; D010963:Plasmodium falciparum / Q000737:chemistry / Q000187:drug effects / Q000235:genetics*; D015995:Prevalence; D011498:Protein Precursors / Q000032:analysis / Q000235:genetics; D015800:Protozoan Proteins / Q000032:analysis / Q000235:genetics; D011739:Pyrimethamine / Q000494:pharmacology; D012621:Seasons; D013397:Sudan / Q000453:epidemiology
D000953:Antigens, Protozoan; D000954:Antigens, Surface; D020066:Merozoite Surface Protein 1; D011498:Protein Precursors; D015800:Protozoan Proteins; C065974:merozoite surface protein 2, Plasmodium; D002738:Chloroquine; D010450:Endopeptidases; D000619:Aminohydrolases; C018774:adenine deaminase; D005956:Glucose-6-Phosphate Isomerase; D011739:Pyrimethamine