Differences in processing of an autoantigen by DR4:Dw4.2 and DR4:Dw14.2 antigen-presenting cells.
Variations in antigen processing can influence class II-restricted T cell responses. We now report a highly significant difference (p < 0.001) between the ability of antigen-presenting cells from three HLA-DR4:Dw14.2 (Arg71) and six DR4:Dw4.2 (Lys71) individuals to present recombinant or native acetylcholine receptor antigens to a myasthenia gravis T cell clone. The difference was greatest with longer antigens, and not seen with short synthetic peptides, suggesting that it may result from a difference in antigen processing between the two alleles. The results were not related to the presence of myasthenia gravis or of steroid therapy. They could, however, be of relevance in rheumatoid arthritis where particularly severe disease associates with Dw4.2/Dw14.2 heterozygosity.
Nicolle
M W
MW
Institute of Molecular Medicine, John Radcliffe Hospital, University of Oxford, GB.
Hawke
S
S
Willcox
N
N
Vincent
A
A
D000938:Antigen-Presenting Cells / Q000378:metabolism*; D001324:Autoantigens / Q000378:metabolism*; D002999:Clone Cells; D005260:Female; D015804:HLA-DR4 Antigen / Q000276:immunology*; D006801:Humans; D009157:Myasthenia Gravis / Q000276:immunology
D001324:Autoantigens; D015804:HLA-DR4 Antigen