Antioxidant properties of phenyl styryl ketones.
Phenolic and non phenolic derivatives of phenyl styryl ketones were synthesized and evaluated as in vitro inhibitors of iron and cumene hydroperoxide dependent lipid peroxidation in rat brain homogenates. The compounds were also tested for antioxidant activity in phosphatidylcholine liposomes. Phenyl 3,5-di-tert-butyl-4-hydroxystyryl ketone was found to be the most potent inhibitor of peroxidation among all the compounds tested. It was found to be more active than vitamin E. It also reduced the stable free radical 1,1-diphenyl-2-picrylhydrazyl to an appreciable extent.
Rajakumar
D V
DV
Department of Pharmaceutical Chemistry, College of Pharmaceutical Sciences, Manipal, India.
Rao
M N
MN
D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D001555:Benzene Derivatives / Q000378:metabolism; D015764:Bepridil / Q000031:analogs & derivatives / Q000378:metabolism; D001713:Biphenyl Compounds; D001921:Brain / Q000378:metabolism*; D003474:Curcumin / Q000032:analysis* / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D066298:In Vitro Techniques; D058085:Iron Compounds / Q000378:metabolism; D015227:Lipid Peroxidation / Q000187:drug effects*; D008081:Liposomes / Q000378:metabolism; D008297:Male; D010851:Picrates; D011281:Pregnatrienes / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D017392:Thiobarbituric Acid Reactive Substances / Q000737:chemistry; D013997:Time Factors; D014810:Vitamin E / Q000494:pharmacology
D000975:Antioxidants; D001555:Benzene Derivatives; D001713:Biphenyl Compounds; D058085:Iron Compounds; D008081:Liposomes; D010851:Picrates; D011281:Pregnatrienes; D017392:Thiobarbituric Acid Reactive Substances; C074965:U 74389F; D014810:Vitamin E; D015764:Bepridil; C004931:1,1-diphenyl-2-picrylhydrazyl; D003474:Curcumin; C007164:cumene hydroperoxide