Brain electrobiogenesis protection induced by nimodipine and MK-801 during acute hypoxia in hypertensive rats.
The protective effect of nimodipine, a calcium entry blocker, and MK-801, an excitatory amino acid antagonist, on the cortical electrobiogenesis of hypertensive SHR-Charles-River adult rats during a 90-s session of acute hypoxia, was tested either with a single treatment or with a therapeutic association. Pretreatment with nimodipine alone (0.1 mg kg-1, i.v.) was particularly effective in increasing the rat brain resistence to hypoxia when compared to the controls. MK-801 pretreatment alone (3 mg kg-1, subcutaneous), improved significantly the recovery of brain electrical activity from hypoxia, as it not only shortened the recovery time but also abolished the post-hypoxic burst activity. The combined pretreatment with both drugs, using the same doses, displayed a more powerful brain protective effect on the cortical electrobiogenesis than the single drug pretreatment, suggesting the existence of a synergy between nimodipine and MK-801.
De Riu
P L
PL
Department of Traumatology, Chair of Neurological Rehabilitation, Turin University, Italy.
Demontis
M P
MP
Anania
V
V
Caria
M A
MA
Mameli
O
O
Becciu
A
A
Tolu
E
E
D000208:Acute Disease; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000503:physiopathology; D016291:Dizocilpine Maleate / Q000494:pharmacology*; D004357:Drug Synergism; D005260:Female; D006973:Hypertension / Q000503:physiopathology*; D000860:Hypoxia / Q000503:physiopathology*; D008297:Male; D009553:Nimodipine / Q000494:pharmacology*; D051381:Rats; D011918:Rats, Inbred SHR
D009553:Nimodipine; D016291:Dizocilpine Maleate