title: The alterations in the energy linked properties induced in rat liver mitochondria by acetylsalicylate are prevented by cyclosporin A or Mg2+.
abstract: The alterations in rat liver mitochondria induced by acetylsalicylate in the presence of low concentrations of Ca2+ (large amplitude swelling, permeability to 14C]sucrose, collapse of transmembrane potential and effluxes of endogenous Mg2+ and accumulated Ca2+) were fully prevented by either cyclosporin A or Mg2+. Cyclosporin A and Mg2+ were also capable of restoring transmembrane potential upon its decrease induced by acetylsalicylate. The loss of endogenous Mg2+ was the primary effect promoted by acetylsalicylate; the other noxious effects followed. These results indicate that Mg2+ are fundamental components of the mitochondrial permeability barrier and that their loss might be responsible for the membrane transition induced by acetylsalicylate.
authors.affiliation: Dipartimento di Chimica Biologica, Universitá id Padova, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Biban
authors.forename: V
authors.initials: V
authors.lastname: Tassani
authors.forename: A
authors.initials: A
authors.lastname: Toninello
authors.forename: D
authors.initials: D
authors.lastname: Siliprandi
authors.forename: N
authors.initials: N
authors.lastname: Siliprandi
mesh_terms: D000818:Animals; D001241:Aspirin / Q000037:antagonists & inhibitors*; D002118:Calcium / Q000378:metabolism; D016572:Cyclosporine / Q000494:pharmacology*; D008274:Magnesium / Q000378:metabolism / Q000494:pharmacology*; D008564:Membrane Potentials; D008930:Mitochondria, Liver / Q000187:drug effects / Q000378:metabolism*; D010539:Permeability; D051381:Rats; D013395:Sucrose / Q000378:metabolism
chemical_list: D013395:Sucrose; D016572:Cyclosporine; D008274:Magnesium; D001241:Aspirin; D002118:Calcium