N-Methyl-D-aspartate receptor subunits NR1 and NR2C are overexpressed in the inferior colliculus of audiogenic mice.
Some non-DBA2 Albino Swiss mice exhibit noise induced epileptic seizures during a short period of postnatal development. Because N-methyl-D-aspartate (NMDA) glutamate ionotropic receptors are involved in the occurrence of audiogenic seizures, we investigated by in situ hybridization methods, the expression of the different subunits (NR1, NR2A, NR2B, NR2C) of this receptor in the central nucleus of the inferior colliculus (IC), a main relay of the auditory pathways. At postnatal day 20, the NR2C subunit is highly expressed in the IC of convulsive mice, while in non-convulsive mice a slight signal is only found for NR1, NR2A, and NR2B. In adult mice, the NR1 and NR2A signals are observed while the NR2B signal is almost undetectable. The audiogenic susceptibility may be related to the transient expression of the NR2C subunit during a brief neonatal period during which synaptic reorganization happens.
Marianowski
R
R
Laboratoire d'Otologie Expérimentale, Faculté Lariboisière, Paris, France.
Pollard
H
H
Moreau
J
J
Després
G
G
Ben Ari
Y
Y
Tran Ba Huy
P
P
Romand
R
R
D000161:Acoustic Stimulation; D000818:Animals; D001345:Autoradiography; D001483:Base Sequence; D001933:Brain Stem / Q000378:metabolism; D016291:Dizocilpine Maleate / Q000494:pharmacology; D017403:In Situ Hybridization; D066298:In Vitro Techniques; D007245:Inferior Colliculi / Q000378:metabolism*; D051379:Mice; D008811:Mice, Inbred DBA; D008969:Molecular Sequence Data; D009473:Neuronal Plasticity / Q000502:physiology; D015345:Oligonucleotide Probes; D016194:Receptors, N-Methyl-D-Aspartate / Q000037:antagonists & inhibitors / Q000096:biosynthesis*; D012640:Seizures / Q000378:metabolism* / Q000503:physiopathology; D013045:Species Specificity
D015345:Oligonucleotide Probes; D016194:Receptors, N-Methyl-D-Aspartate; D016291:Dizocilpine Maleate