[Study of type I and IV collagenase activity in human thyroid diseases].
The activity of type I and IV collagenase was measured in thyroid tissue obtained from 6 non-diseased thyroids, 4 patients with Graves' diseases, 5 with follicular adenoma, 6 with papillary carcinoma and 4 with follicular carcinomas. The relationship between these enzyme activities and invasion or metastasis of the original tumors was studied. The activity of type I collagenase in papillary carcinomas and follicular carcinomas was higher than in non-diseased thyroids, Graves' disease and follicular adenoma. Carcinoma tissue with invasion beyond the capsule in particular had higher type I collagenase activity. Type IV collagenase activity in carcinoma with lymph node metastasis was higher than in non-diseased thyroids, Graves' disease and follicular adenoma, and especially higher than carcinoma without lymph node metastasis. These findings suggest that increased type I collagenase activity plays an important role in local invasion in thyroid carcinoma, and that increased type IV collagenase activity plays an important role in lymph node metastasis.
Nakano
T
T
Department of Otolaryngology, Kinki University School of Medicine, Osaka.
Kusunoki
T
T
Funasaka
K
K
Murata
K
K
Nishida
S
S
tomura
T
T
D018263:Adenocarcinoma, Follicular / Q000201:enzymology; D000236:Adenoma / Q000201:enzymology; D002291:Carcinoma, Papillary / Q000201:enzymology; D017364:Collagenases / Q000378:metabolism*; D006111:Graves Disease / Q000201:enzymology; D006801:Humans; D013959:Thyroid Diseases / Q000201:enzymology*; D013961:Thyroid Gland / Q000201:enzymology; D013964:Thyroid Neoplasms / Q000201:enzymology
D017364:Collagenases