title: Sequence of an exon of tumour suppressor p53 gene--a comparative study in domestic animals: mutation in a feline solid mammary carcinoma.
abstract: Partial sequence determinations were performed on exon 8 of tumour suppressor gene p53 of cattle, sheep, goat, horse and pig. High sequence homology between these species and other species including dog, cat, chicken and man is demonstrated. A mutation CGG-->TGG (arginine-->tryptophan) was detected in a feline solid carcinoma of the mammary gland.
authors.affiliation: Institute for Animal Breeding and Genetics, Veterinary University, Vienna, Austria.
authors.forename: B
authors.initials: B
authors.lastname: Mayr
authors.forename: G
authors.initials: G
authors.lastname: Schaffner
authors.forename: R
authors.initials: R
authors.lastname: Kurzbauer
authors.forename: M
authors.initials: M
authors.lastname: Reifinger
authors.forename: K
authors.initials: K
authors.lastname: Schellander
mesh_terms: D000818:Animals; D000829:Animals, Domestic / Q000235:genetics*; D001483:Base Sequence; D002371:Cat Diseases / Q000235:genetics* / Q000473:pathology; D002415:Cats; D017931:DNA Primers / Q000737:chemistry; D004273:DNA, Neoplasm / Q000032:analysis; D005091:Exons; D016158:Genes, p53 / Q000235:genetics*; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000235:genetics* / Q000473:pathology; D008969:Molecular Sequence Data; D009154:Mutation / Q000235:genetics*; D016133:Polymerase Chain Reaction / Q000662:veterinary; D012689:Sequence Homology, Nucleic Acid
chemical_list: D017931:DNA Primers; D004273:DNA, Neoplasm