title: Percutaneous absorption of tritium-gas-contaminated pump oil.
abstract: One of the radiological problems encountered in tritium handling facilities is the hazards associated with tritium's ability to label and degrade organic materials. Experiments in which male hairless rats have been contaminated with tritium-gas-contaminated pump oil have demonstrated that tritium deposited on the skin provides an input of organically bound tritium and tritiated water in the body. The accumulation of organically bound tritium at the point of contact in the skin and in various tissues influenced tritium excretion in urine and feces. The retention of tritium in the body showed that tritium was mainly metabolized and assimilated as organically bound tritium. The distribution of tritiated water was rapid and uniform in the whole-body. Analyses of tritium excreted in animal urine and feces showed that a significant level of organically bound tritium was excreted shortly after exposure. The highest concentration of tritium activity was measured in the exposed area of the skin. An increased level of tritium accumulation in the liver and kidneys was seen. Dose calculations showed that the exposed skin had the highest dose, and the skin dose was primarily due to the retention of organically bound tritium at the point of contact. The interpretation of these data has indicated that the retention of short-term organically bound tritium in the skin may be a dominant factor for dosimetry purposes.
authors.affiliation: Radiation Biology and Health Physics Branch, AECL, Chalk River, Ontario, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Trivedi
mesh_terms: D000042:Absorption; D000396:Air Pollutants, Radioactive / Q000493:pharmacokinetics* / Q000633:toxicity; D000818:Animals; D005243:Feces / Q000737:chemistry; D006207:Half-Life; D006283:Health Physics; D008297:Male; D008954:Models, Biological; D009821:Oils / Q000493:pharmacokinetics* / Q000633:toxicity; D011829:Radiation Dosage; D051381:Rats; D011923:Rats, Nude; D012867:Skin / Q000378:metabolism*; D014018:Tissue Distribution; D014316:Tritium / Q000493:pharmacokinetics* / Q000633:toxicity / Q000652:urine
chemical_list: D000396:Air Pollutants, Radioactive; D009821:Oils; D014316:Tritium