[Cutaneous reactions to gold salts].
OBJECTIVE
Evaluate the clinical features of skin reactions to gold salts.


BACKGROUND
Gold dermatitis is described in the literature as a group of reactions non-specifically associated with these drugs.


METHODS
Ten patients (7 males, 3 females, mean age 59.6 years [corrected] with a skin reaction were studied over a 6 year period. All were treated with Allochrysine for rheumatoid arthritis (n = 8), rhizomelic pseudopolyarthritis (n = 1) or arthropathic psoriasis (n = 1).


RESULTS
The delay to the first signs was from 2 weeks to 8 months. Three lichenoid eruptions (including two with buccal lesions and two which followed an autonomous course), 2 pityriasis rosea (one with eosinophilia and one with liver disease), 2 eczematoid dermatoses and one urticaria were observed. Pathology examinations (8/10) were in agreement with clinical diagnosis. Imputability was 14 (1 case), 13 (8 cases) and 12 (1 case).


CONCLUSIONS
The clinical features observed were variable and in agreement with a particular clinical situation. They were not specific to gold salts and cannot be qualified as "gold dermatitis". Two autonomous and severe lichenoid eruptions were observed. Generalized lesions were associated with biological signs. This situation must be considered as a marker of severity.
Lizeaux-Parneix
V
V
Service de Dermatologie, CHU Dupuytren, Limoges.
Bedane
C
C
Lavignac
C
C
Bernard
P
P
Bonnetblanc
J M
JM
D000328:Adult; D000368:Aged; D018501:Antirheumatic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003873:Dermatitis, Exfoliative / Q000139:chemically induced; D003875:Drug Eruptions / Q000209:etiology* / Q000473:pathology; D004485:Eczema / Q000139:chemically induced; D005260:Female; D006801:Humans; D007273:Injections, Intramuscular; D017512:Lichenoid Eruptions / Q000139:chemically induced; D008297:Male; D008875:Middle Aged; D050607:Organogold Compounds
D018501:Antirheumatic Agents; D050607:Organogold Compounds
Réactions cutanées aux sels d'or.