[Effect of tetramethylhyrazine on proliferation of human fetal mesangial cells].
Tetramethylhyrazine (TMP) 0.6 and 1.2 mmol were added to human fetal mesangial cell (MC) cultures for 6 days, and the amounts of MC (cells/ml) were 37580 +/- 3475 and 27350 +/- 3418 respectively, significantly lower than that 71850 +/- 5108 in control (P < 0.05). The 3H-TdR incorporation by the MC with corresponding TMP were 1017 +/- 201 and 583 +/- 271, also significantly lower, than that 3575 +/- 306 in control (P < 0.01). After adding the TMP (1 mmol) to the cultures, the IL-6 bioactivity were 2118 +/- 215 that were markedly lower than those in controls (4128 +/- 351, P < 0.01). It revealed that the TMP inhibited the growth of MC and the mechanism of its inhibition might be due to that TMP could reduce the IL-6.
Sun
L
L
Dept. of Pediatrics, Second Affiliated Hospital, Human Medical University, Changsha.
Yi
Z W
ZW
Yu
P L
PL
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D017077:Culture Media, Conditioned; D005333:Fetus; D005920:Glomerular Mesangium / Q000166:cytology* / Q000378:metabolism; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis; D011719:Pyrazines / Q000494:pharmacology*
D017077:Culture Media, Conditioned; D015850:Interleukin-6; D011719:Pyrazines; C017953:tetramethylpyrazine