title: Biosynthetic capacities of actinomycetes. 4. Echinoserine, a new member of the quinoxaline group, produced by Streptomyces tendae.
abstract: A new member of the quinoxaline group antibiotics has been detected by HPLC-diode-array screening. The main compound produced by Streptomyces tendae strain Tü 4031 showed a high degree of similarity in the UV-visible spectral region with echinomycin and their structural similarity was confirmed by structure elucidation using electron tandem mass spectrometry and 2D nuclear magnetic resonance. The new compound, named echinoserine, is a non-cyclic form of echinomycin, but it is not a biosynthetic precursor. Echinoserine is less antibiotically active than echinomycin.
authors.affiliation: Biologisches Institut, Universität Tübingen, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Blum
authors.forename: H P
authors.initials: HP
authors.lastname: Fielder
authors.forename: I
authors.initials: I
authors.lastname: Groth
authors.forename: C
authors.initials: C
authors.lastname: Kempter
authors.forename: H
authors.initials: H
authors.lastname: Stephan
authors.forename: G
authors.initials: G
authors.lastname: Nicholson
authors.forename: J W
authors.initials: JW
authors.lastname: Metzger
authors.forename: G
authors.initials: G
authors.lastname: Jung
mesh_terms: D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002851:Chromatography, High Pressure Liquid; D004448:Echinomycin / Q000031:analogs & derivatives* / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D008826:Microbial Sensitivity Tests; D013302:Streptomyces
chemical_list: D000903:Antibiotics, Antineoplastic; C095341:echinoserine; D004448:Echinomycin