ATP-evoked membrane current in guinea pig adrenal chromaffin cells.
Adenosine 5'-triphosphate (ATP) evoked an inward current in whole-cell voltage-clamped adrenal chromaffin cells of the guinea pig. The reversal potential (Erev) of ATP-evoked current was about 0 mV in normal external solution and was shifted towards negative potentials by substituting Tris+ or sucrose, but not Ca2+, for the extracellular Na+. This current was mediated by the activation of non-selective cation channels and had some different properties from nicotinic current. It is suggested that these channels may function as a part of the ATP-induced Ca2+ influx pathway in guinea pig chromaffin cells.
Otsuguro
K
K
Department of Pharmacology, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Japan.
Asano
T
T
Ohta
T
T
Ito
S
S
Nakazato
Y
Y
D000255:Adenosine Triphosphate / Q000494:pharmacology*; D000311:Adrenal Glands / Q000187:drug effects; D000818:Animals; D002837:Chromaffin Granules / Q000187:drug effects*; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008564:Membrane Potentials / Q000187:drug effects*; D009538:Nicotine / Q000494:pharmacology; D018408:Patch-Clamp Techniques; D012964:Sodium / Q000494:pharmacology
D009538:Nicotine; D000255:Adenosine Triphosphate; D012964:Sodium