title: Early detection of catabolic state via change in 13C/12C ratios of blood proteins.
abstract: We find that induction of catabolic state changes the ratios of carbon 13 to carbon 12 in blood proteins. Diet can be inferred in growing chicks by feather carbon isotope ratios. This suggests an approach for early detection of catabolic state induced in patients with HIV, cancers that induce catabolism, infection onset, sepsis, kidney and liver disease, malnutrition and dietary problems. The technique would also be useful in animal husbandry.
authors.affiliation: Department of Zoology, University of Wisconsin, Madison 53706, USA.
authors.forename: K A
authors.initials: KA
authors.lastname: Hatch
authors.forename: K A
authors.initials: KA
authors.lastname: Sacksteder
authors.forename: I W
authors.initials: IW
authors.lastname: Treichel
authors.forename: M E
authors.initials: ME
authors.lastname: Cook
authors.forename: W P
authors.initials: WP
authors.lastname: Porter
mesh_terms: D000818:Animals; D001798:Blood Proteins / Q000737:chemistry* / Q000378:metabolism*; D002244:Carbon / Q000032:analysis*; D002247:Carbon Isotopes; D002645:Chickens; D004032:Diet; D005241:Feathers / Q000737:chemistry / Q000254:growth & development; D005260:Female; D006454:Hemoglobins / Q000737:chemistry / Q000378:metabolism; D006801:Humans; D008297:Male
chemical_list: D001798:Blood Proteins; D002247:Carbon Isotopes; D006454:Hemoglobins; D002244:Carbon