[The correction of disorders in arachidonic acid metabolism in coronary spasm of an immune origin].
The effect of phosphocreatine and hydroxamate-linoleate (an inhibitor of lipoxigenase) on development of the pathologic process in coronary vessels with immune (cytotoxic) injury of the heart was studied in the experiments on narcotized dogs. Development of the immune response after administration of cardiac serum resulted in development of large transmural damage of the left ventricle myocardium, increased resistance of coronary vessels and changed coronary vascular reactions, which correlates with changes in arachidonic acid metabolism. Experimental data described in this report demonstrate the efficiency of membrane coronary vessels stabilization and inhibition of a lipoxygenase pathway in arachidonic acid metabolism in protection of immune damage of the heart and coronary vessels.
Marchenko
H I
HI
Kotsiuruba
V M
VM
Butovych
I A
IA
Sorochyns'kyĭ
A E
AE
Zrazhevs'ka
V K
VK
Tumanovs'ka
L V
LV
D000818:Animals; D016718:Arachidonic Acid / Q000097:blood*; D003329:Coronary Vasospasm / Q000097:blood* / Q000188:drug therapy / Q000209:etiology / Q000276:immunology; D004195:Disease Models, Animal; D004285:Dogs; D004353:Drug Evaluation, Preclinical; D007106:Immune Sera; D017997:Leukotriene C4 / Q000097:blood; D008041:Linoleic Acids / Q000627:therapeutic use; D008084:Lipoxygenase / Q000097:blood / Q000187:drug effects; D016859:Lipoxygenase Inhibitors / Q000627:therapeutic use; D009206:Myocardium / Q000276:immunology; D010725:Phosphocreatine / Q000627:therapeutic use
D007106:Immune Sera; D008041:Linoleic Acids; D016859:Lipoxygenase Inhibitors; D010725:Phosphocreatine; D016718:Arachidonic Acid; C089594:linoleic acid hydroxamate; D017997:Leukotriene C4; D008084:Lipoxygenase
Korektsiia porushen' metabolizmu arakhidonovoï kysloty pry koronarospazmi imunnoho henezu.