Interleukin-1 contributes to increased concentrations of soluble tumor necrosis factor receptor type I in sepsis.
Studies were done in baboons and humans to assess the role of interleukin (IL)-1 on the release of soluble tumor necrosis factor receptors (sTNFRs) during sepsis. In baboons, IL-1 alpha induced increased levels of sTNFR types I and II. Infusion of Escherichia coli into baboons also led to higher sTNFR levels. Treatment with IL-1 receptor antagonist (ra) attenuated the rise in sTNFR-I, which was positively correlated with a partial preservation of renal function by IL-1ra. In patients with sepsis, treatment with IL-1ra also was associated with lower levels of sTNFR-1 but did not influence plasma creatinine levels. IL-1ra did not affect sTNFR-II in baboons or humans. These data suggest that IL-1 produced during sepsis is involved in increases in sTNFR-I. Such increases during rapidly fatal septic shock may in part be explained by an effect on the renal clearance of sTNFR-I.
van der Poll
T
T
Department of Surgery (Laboratory of Surgical Metabolism), Cornell University Medical College, New York, New York 10021, USA.
Fischer
E
E
Coyle
S M
SM
Van Zee
K J
KJ
Pribble
J P
JP
Stiles
D M
DM
Barie
P S
PS
Buurman
W A
WA
Moldawer
L L
LL
Lowry
S F
SF
D000368:Aged; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology; D016022:Case-Control Studies; D003404:Creatinine / Q000097:blood; D004926:Escherichia coli / Q000276:immunology; D005260:Female; D006801:Humans; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1 / Q000494:pharmacology*; D008875:Middle Aged; D010215:Papio; D017472:Receptors, Interleukin-1 / Q000037:antagonists & inhibitors; D018124:Receptors, Tumor Necrosis Factor / Q000096:biosynthesis* / Q000276:immunology; D011994:Recombinant Proteins / Q000494:pharmacology*; D018805:Sepsis / Q000188:drug therapy*; D012795:Sialoglycoproteins / Q000494:pharmacology
D000942:Antigens, Bacterial; C507763:IL1RN protein, human; D053590:Interleukin 1 Receptor Antagonist Protein; D007375:Interleukin-1; D017472:Receptors, Interleukin-1; D018124:Receptors, Tumor Necrosis Factor; D011994:Recombinant Proteins; D012795:Sialoglycoproteins; D003404:Creatinine