[Effects of glucocorticoid on PMN adhesion induced by TNF].
TNF was used as a stimulating factor to study the effects of glucocorticoid (GC) on polymorphonuclear leucocyte (PMN) adhesion. The results showed that tumor necrosis factor (TNF) could increase the PMN adhesion markedly, and Dex could not inhibit the PMN adhesion induced by TNF, but it had a certain effect of prevention. PMN adhesion was increased prominently when Dex and RU 38486 were given after TNF pretreatment.
Yan
M
M
304th Hospital of People's Liberation Army, Beijing.
Gong
X
X
Zhang
Y
Y
D000818:Animals; D001011:Aorta; D002448:Cell Adhesion / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D004730:Endothelium, Vascular / Q000166:cytology; D005938:Glucocorticoids / Q000494:pharmacology*; D008297:Male; D015735:Mifepristone / Q000494:pharmacology; D009504:Neutrophils / Q000502:physiology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors*
D005938:Glucocorticoids; D014409:Tumor Necrosis Factor-alpha; D015735:Mifepristone; D003907:Dexamethasone