title: Chaos in intracellular Ca2+ oscillations in a new model for non-excitable cells.
abstract: A new model for intracellular Ca2+ oscillations is presented. The new model reinterprets two previous models, the ICC and CICR mechanisms, and incorporates the bell-shaped dependence of Ca2+ release on cytosolic [Ca2+]. Complex oscillations and chaos are found with this new model, confirming experimental observations of complex oscillations. A rich bifurcation sequence is found for the model as the stimulation due to agonist (R) is varied, including a period doubling route to chaos and a period-adding sequence of mixed-mode states.
authors.affiliation: Department of Chemistry, Indiana University Purdue University Indianapolis, USA.
authors.forename: P
authors.initials: P
authors.lastname: Shen
authors.forename: R
authors.initials: R
authors.lastname: Larter
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D015220:Calcium Channels / Q000502:physiology; D002451:Cell Compartmentation; D003600:Cytosol / Q000378:metabolism; D005246:Feedback; D019204:GTP-Binding Proteins / Q000502:physiology; D015544:Inositol 1,4,5-Trisphosphate / Q000502:physiology; D008954:Models, Biological; D017711:Nonlinear Dynamics; D019269:Phosphatidylinositol 4,5-Diphosphate; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D018129:Phosphatidylinositol Phosphates / Q000378:metabolism; D010727:Phosphoric Diester Hydrolases / Q000502:physiology; D011956:Receptors, Cell Surface / Q000502:physiology; D015398:Signal Transduction
chemical_list: D015220:Calcium Channels; D019269:Phosphatidylinositol 4,5-Diphosphate; D018129:Phosphatidylinositol Phosphates; D011956:Receptors, Cell Surface; D015544:Inositol 1,4,5-Trisphosphate; D010727:Phosphoric Diester Hydrolases; D019204:GTP-Binding Proteins; D043265:Phosphatidylinositol Diacylglycerol-Lyase; D002118:Calcium