Chronotropic and blood pressure response to oral glucose load in Chagas' disease.
Cardiac chronotropic and pressor responses after an oral load of glucose were assessed in sixteen Chagasic subjects and 28 controls by means of blood pressure and pulse rate measurements. Cardiovascular response was correlated with serum insulin and glucose levels. The experiment identified a subgroup of Chagasic subjects (n = 8) with a hypoinsulinemic behavior presenting less chronotropic and pressor responses than controls. This may indicate a lower insulin activity and/or an early Autonomic Nervous System dysfunction in this subgroup.
Guariento
M E
ME
Department of Internal Medicine at Campinas State University, São Paulo, Brazil.
Olga
E
E
Muscelli
A
A
Gontijo
J A
JA
D000328:Adult; D001786:Blood Glucose / Q000032:analysis; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D014355:Chagas Disease / Q000503:physiopathology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D005947:Glucose / Q000494:pharmacology; D005951:Glucose Tolerance Test; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D007328:Insulin / Q000097:blood / Q000502:physiology; D008297:Male; D008875:Middle Aged
D001786:Blood Glucose; D007328:Insulin; D005947:Glucose