[Fibronectin and macrophage].
Monocyte-macrophages play a great part in atherogenesis. Interaction between macrophages and subendothelial-tissue including basement membrane and intima may play a critical role in atherogenesis. Therefore we examined the ability of macrophages to attach to various types of extracellular matrix proteins, which are the main components of these tissues. Adhesion of macrophages to fibronectin was remarkable compared to collagen. In addition we examined the effect of age on adhesion to fibronectin. Age-related increase in macrophage adhesion to fibronectin was found in vitro. It was also related to the concentration of surface receptors of macrophages which recognize the RGDS sequence within fibronectin (i.e. VLA5) during aging. Age-related increases in macrophage ability to attach to fibronectin may be related to atherogenesis during aging.
Iiyama
M
M
Department of Geriatric Medicine, Kyoto University.
Shimada
Y
Y
Kita
T
T
Ito
H
H
D000375:Aging / Q000502:physiology*; D000595:Amino Acid Sequence; D000818:Animals; D016326:Extracellular Matrix Proteins / Q000502:physiology; D005353:Fibronectins / Q000502:physiology*; D066298:In Vitro Techniques; D008264:Macrophages / Q000502:physiology*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000502:physiology
D016326:Extracellular Matrix Proteins; D005353:Fibronectins; D009842:Oligopeptides; C046617:arginyl-glycyl-aspartyl-serine