Inversions with deletions and duplications.
Complex mutational events, including de novo inversion with deletion and duplication of sequence, have been observed but are difficult to model. We propose that nascent leading-strand misalignment upon the lagging-strand template during DNA replication can result in the inversion of sequence. The positioning of this misalignment and of the realignment of the leading strand back into the leading-strand template will determine if the inversion is accompanied by deletion and duplication of sequence. We suggest that such strand misalignment-realignment events may occur at the replication fork during concurrent DNA replication.
Gordon
A J
AJ
Section de Biologie, Institut Curie, Paris, France.
Halliday
J A
JA
D001483:Base Sequence; D007446:Chromosome Inversion; D004261:DNA Replication; D004269:DNA, Bacterial / Q000096:biosynthesis / Q000235:genetics; D004277:DNA, Single-Stranded / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D017353:Gene Deletion; D008957:Models, Genetic; D008969:Molecular Sequence Data; D005810:Multigene Family; D009154:Mutation; D012689:Sequence Homology, Nucleic Acid; D013698:Templates, Genetic
D004269:DNA, Bacterial; D004277:DNA, Single-Stranded