title: [Acute infectious myocarditis in children. Apropos of 2 series from Lyon].
abstract: Acute infectious myocarditis in childhood has a very poor initial outcome, but the long-term outlook is relatively good for the survivors. This retrospective study was based on cases of acute myocarditis admitted to two hospital departments with different modes of recruitment. Firstly, a polyvalent paediatric intensive care unit where 12 children (mean age 12 months) were admitted during the acute phase of myocarditis. The initial symptoms were non-specific and misleading, the diagnosis being established at autopsy in 9 cases. Only 4 children presented with typical cardiac failure. The clinical signs were hepatomegaly, sinus tachycardia, cardiomegaly, ECG ST-T wave changes and biological signs of multiple organ failure. Left ventricular function was very poor with a fractional shortening of only 17%. The causal agent was usually viral. The clinical course was marked by a high early mortality (11/26, 42%) within 23 hours of hospital admission. Secondly, a paediatric cardiology unit where 81 children (mean age 15 months) were followed up after acute infectious myocarditis. Thirteen cases were taken from our first series and were included for long-term follow-up; 76.5% had premonitory signs of infection and 71% were in cardiac failure, Classes III or IV, during the hospital admission. The causal agent was identified in 30 cases (37%) and was usually a virus (22 cases). Treatment was classical (association of digitalis, diuretics, angiotensin converting enzyme inhibitors, anticoagulants and beta-sympathomimetics when necessary).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Hôpital cardiovasculaire et pneumologique Louis-Pradel, Lyon.
authors.forename: M
authors.initials: M
authors.lastname: Gouton
authors.forename: S
authors.initials: S
authors.lastname: Di Filippo
authors.forename: F
authors.initials: F
authors.lastname: Sassolas
authors.forename: D
authors.initials: D
authors.lastname: Stamm
authors.forename: A
authors.initials: A
authors.lastname: Bozio
authors.forename: D
authors.initials: D
authors.lastname: Floret
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000704:Analysis of Variance; D001424:Bacterial Infections / Q000401:mortality / Q000628:therapy; D002648:Child; D002675:Child, Preschool; D005260:Female; D005602:France; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D015278:Intensive Care Units, Pediatric; D008297:Male; D009205:Myocarditis / Q000382:microbiology* / Q000401:mortality / Q000628:therapy; D011379:Prognosis; D012189:Retrospective Studies; D014777:Virus Diseases / Q000401:mortality / Q000628:therapy
vernacular_title: Les myocardites aiguës infectieuses de l'enfant. A propos de deux séries lyonnaises.