title: Renal artery stenosis: evaluation of Doppler US after inhibition of angiotensin-converting enzyme with captopril.
abstract: OBJECTIVE
  To evaluate the modifications of Doppler ultrasound waveform morphology after inhibition of angiotensin-converting enzyme with captopril to increase the sensitivity of Doppler sonography in detecting renal artery stenosis.
  
  
  METHODS
  Sixty-two renal arteries were studied in 31 hypertensive patients who underwent Doppler scanning before and 1 hour after administration of captopril prior to undergoing angiography. Pattern recognition criteria were applied to classify the Doppler waveforms as having a normal or pulsus tardus configuration. Doppler scanning results were compared with those of arteriography.
  
  
  RESULTS
  On the basis of recognition of the pulsus tardus, precaptopril Doppler scanning showed 13 (68%) of 19 significant renal artery stenoses found at angiography (95% confidence interval, 0.43, 0.85), whereas 19 (100%) of 19 stenoses were detected with postcaptopril Doppler scanning (95% confidence interval, 0.85, 1.0).
  
  
  CONCLUSIONS
  Captopril significantly (95% confidence intervals) increases Doppler scanning sensitivity in detecting renal artery stenoses by inducing or enhancing the pulsus tardus distal to a significant renal artery stenosis.
authors.affiliation: Department of Radiology, Hôpital Notre-Dame, Montreal, Quebec, Canada.
authors.forename: P C
authors.initials: PC
authors.lastname: René
authors.forename: V L
authors.initials: VL
authors.lastname: Oliva
authors.forename: B T
authors.initials: BT
authors.lastname: Bui
authors.forename: D
authors.initials: D
authors.lastname: Froment
authors.forename: C
authors.initials: C
authors.lastname: Harel
authors.forename: V
authors.initials: V
authors.lastname: Nicolet
authors.forename: M
authors.initials: M
authors.lastname: Courteau
authors.forename: L
authors.initials: L
authors.lastname: Carignan
mesh_terms: D000328:Adult; D000368:Aged; D015901:Angiography, Digital Subtraction; D001027:Aortography; D002216:Captopril; D016001:Confidence Intervals; D005260:Female; D006801:Humans; D006978:Hypertension, Renovascular / Q000000981:diagnostic imaging; D008297:Male; D008875:Middle Aged; D010363:Pattern Recognition, Automated; D011446:Prospective Studies; D011674:Pulse; D012077:Renal Artery / Q000000981:diagnostic imaging / Q000187:drug effects; D012078:Renal Artery Obstruction / Q000000981:diagnostic imaging* / Q000503:physiopathology; D012680:Sensitivity and Specificity; D018608:Ultrasonography, Doppler; D014655:Vascular Resistance / Q000187:drug effects
chemical_list: D002216:Captopril