title: Ternary complex therapy for autoimmune disease.
abstract: Induction of an immune response is remarkably simple, involving the interaction of three components: processed antigen, an MHC class II molecule, and a CD4 T-cell receptor. Each part of this ternary complex represents a novel target for interventions that may block subsequent effector phenomena of autoimmune disease. Such specific treatments will be less toxic than those currently available.
authors.affiliation: Division of Immunology and Rheumatology, Stanford University Medical School, USA.
authors.forename: C G
authors.initials: CG
authors.lastname: Fathman
mesh_terms: D000936:Antigen-Antibody Complex; D001327:Autoimmune Diseases / Q000276:immunology / Q000628:therapy*; D015551:Autoimmunity / Q000187:drug effects; D015704:CD4 Antigens / Q000187:drug effects / Q000276:immunology; D006801:Humans; D007167:Immunotherapy / Q000379:methods*; D008285:Major Histocompatibility Complex / Q000187:drug effects / Q000276:immunology; D010455:Peptides / Q000187:drug effects / Q000276:immunology; D011948:Receptors, Antigen, T-Cell / Q000187:drug effects / Q000276:immunology
chemical_list: D000936:Antigen-Antibody Complex; D015704:CD4 Antigens; D010455:Peptides; D011948:Receptors, Antigen, T-Cell