title: Retinal dopamine and lens-induced refractive errors in chicks.
abstract: This study investigated the relationship between retinal dopamine and lens induced refractive errors in chicks by high performance liquid chromatography with ultraviolet detection (HPLC-UV). After two weeks of lens wear, the chick eyes treated with +10D lenses were hyperopic (+8.29 +/- 0.43D), while the eyes treated with -10D lenses were myopic (-11.69 +/- 0.74D). At the same time, in myopic eyes the level of retinal dopamine and its metabolite 3,4-dihydroxy-phenylacetic acid (DOPAC) were reduced compared to control eyes, while in hyperopic eyes the level of retinal dopamine and DOPAC were increased as compared with control eyes. Therefore, retinal dopamine may participate in the development of lens induced refractive errors in chicks.
authors.affiliation: School of Optometry, Department of Biology, University of Waterloo, Ontario, Canada.
authors.forename: S S
authors.initials: SS
authors.lastname: Guo
authors.forename: J G
authors.initials: JG
authors.lastname: Sivak
authors.forename: M G
authors.initials: MG
authors.lastname: Callender
authors.forename: B
authors.initials: B
authors.lastname: Diehl-Jones
mesh_terms: D015102:3,4-Dihydroxyphenylacetic Acid / Q000378:metabolism; D000818:Animals; D002645:Chickens; D002851:Chromatography, High Pressure Liquid; D003261:Contact Lenses / Q000009:adverse effects*; D004298:Dopamine / Q000378:metabolism*; D006956:Hyperopia / Q000209:etiology / Q000378:metabolism*; D009216:Myopia / Q000209:etiology / Q000378:metabolism*; D012160:Retina / Q000378:metabolism*
chemical_list: D015102:3,4-Dihydroxyphenylacetic Acid; D004298:Dopamine