Lack of evidence for a role of HLA-DP in unexplained recurrent spontaneous abortion.
Using the "Polymerase Chain Reaction-Sequence Specific Oligoprobes" (PCR-SSOp) technique, we studied the HLA-DPB locus in both partners of 59 couples with a history of three spontaneous abortions, and of 38 control couples in order to determine the role of this centromeric region of the major histocompatibility complex (MHC) in the immune reaction needed for a favorable course of pregnancy. As no particular phenotypes were noted, and also neither excessive HLA-DP homozygosity in sterile women nor excessive HLA-DP allele sharing between sterile partners, this MHC class II sub-region would seem to play no role either directly or by linkage disequilibrium, in the development of normal pregnancy.
Sagot
P
P
Fédération de Gynécologie-Obstétrique et Biologie de la Reproduction, Centre Hospitalier Régional Universitaire de Nantes.
Bignon
J
J
Cesbron
A
A
Cheneau
M L
ML
Boog
G
G
Muller
J Y
JY
D000026:Abortion, Habitual / Q000235:genetics / Q000276:immunology*; D016022:Case-Control Studies; D002874:Chromosome Mapping; D015343:DNA Probes, HLA; D005260:Female; D005802:Genes, MHC Class II; D006682:HLA-DP Antigens / Q000235:genetics*; D006720:Homozygote; D006801:Humans; D007246:Infertility / Q000235:genetics / Q000276:immunology*; D008297:Male; D010641:Phenotype; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011247:Pregnancy
D015343:DNA Probes, HLA; D006682:HLA-DP Antigens