title: Inversions with deletions and duplications.
abstract: Complex mutational events, including de novo inversion with deletion and duplication of sequence, have been observed but are difficult to model. We propose that nascent leading-strand misalignment upon the lagging-strand template during DNA replication can result in the inversion of sequence. The positioning of this misalignment and of the realignment of the leading strand back into the leading-strand template will determine if the inversion is accompanied by deletion and duplication of sequence. We suggest that such strand misalignment-realignment events may occur at the replication fork during concurrent DNA replication.
authors.affiliation: Section de Biologie, Institut Curie, Paris, France.
authors.forename: A J
authors.initials: AJ
authors.lastname: Gordon
authors.forename: J A
authors.initials: JA
authors.lastname: Halliday
mesh_terms: D001483:Base Sequence; D007446:Chromosome Inversion; D004261:DNA Replication; D004269:DNA, Bacterial / Q000096:biosynthesis / Q000235:genetics; D004277:DNA, Single-Stranded / Q000235:genetics; D004926:Escherichia coli / Q000235:genetics; D017353:Gene Deletion; D008957:Models, Genetic; D008969:Molecular Sequence Data; D005810:Multigene Family; D009154:Mutation; D012689:Sequence Homology, Nucleic Acid; D013698:Templates, Genetic
chemical_list: D004269:DNA, Bacterial; D004277:DNA, Single-Stranded