Myositis and fasciitis associated with group A beta hemolytic streptococcal infections: development of a rabbit model.
Group A streptococci produce a variety of clinical symptoms ranging from minor pharyngeal infections to life-threatening soft-tissue disease. A rabbit model is described for induction of myonecrosis and fasciitis with group A beta-hemolytic streptococci. Group A streptococcal infections have shown remarkable virulence in recent years, resulting in severe local tissue destruction and life-threatening toxicity. After subcutaneous injection into the thigh of 20 ml broth containing 10(5) to 10(9) cfu/ml, initial soft tissue infection rapidly progressed to rhabdomyolysis. The response of the rabbits to the infection was consistent with the human response.
Piepmeier
E
E
College of Pharmacy, University of South Carolina, Columbia 29210, USA.
Hammett-Stabler
C
C
Price
M
M
Peters
J
J
Kemper
G
G
Davis
M
M
D000328:Adult; D000818:Animals; D001831:Body Temperature / Q000502:physiology; D002452:Cell Count; D004195:Disease Models, Animal; D005208:Fasciitis / Q000150:complications* / Q000382:microbiology / Q000503:physiopathology; D006801:Humans; D008214:Lymphocytes / Q000166:cytology; D008297:Male; D018482:Muscle, Skeletal / Q000473:pathology; D009220:Myositis / Q000150:complications* / Q000382:microbiology / Q000503:physiopathology; D009336:Necrosis; D011817:Rabbits; D013290:Streptococcal Infections / Q000150:complications* / Q000473:pathology / Q000503:physiopathology; D013297:Streptococcus pyogenes; D013997:Time Factors