Isolation of a cDNA encoding a novel chicken chemokine homologous to mammalian macrophage inflammatory protein-1 beta.
A cDNA encoding a novel chicken chemokine homologous to mammalian chemokine macrophage inflammatory protein 1 beta (MIP-1 beta) was isolated and characterised. The cDNA encodes a protein which is 75-80% homologous to human and mouse MIP-1 beta. All conserved amino acids characteristic of the mammalian chemokine family have been evolutionarily preserved in chicken MIP-1 beta, suggesting similar protein folding patterns and functional properties.
Petrenko
O
O
Department of Microbiology, State University of New York at Stony Brook 11794, USA.
Ischenko
I
I
Enrietto
P J
PJ
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002461:Cell Line, Transformed; D054407:Chemokine CCL4; D002645:Chickens / Q000235:genetics*; D016207:Cytokines / Q000235:genetics*; D018076:DNA, Complementary / Q000235:genetics / Q000302:isolation & purification; D005796:Genes; D006801:Humans; D019402:Macrophage Inflammatory Proteins; D051379:Mice; D008969:Molecular Sequence Data; D015846:Monokines / Q000235:genetics*; D020572:Oncogene Proteins v-rel; D015682:Retroviridae Proteins, Oncogenic / Q000235:genetics / Q000502:physiology; D017386:Sequence Homology, Amino Acid
D054407:Chemokine CCL4; D016207:Cytokines; D018076:DNA, Complementary; D019402:Macrophage Inflammatory Proteins; D015846:Monokines; D020572:Oncogene Proteins v-rel; D015682:Retroviridae Proteins, Oncogenic