Effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on estrous cyclicity and ovulation in female Sprague-Dawley rats.
The effect of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) on estrous cyclicity and ovulation in Sprague-Dawley rats was examined. TCDD at a single oral dose of 10 micrograms/kg resulted in irregularity of cycles, characterized mainly as prolonged periods of diestrus. In rats cycling normally this dose of TCDD reduced the ovulatory rate and the number of ova recovered. The results suggest that TCDD is a reproductive toxin also in female rats, the mechanism of which is as yet unknown.
Li
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Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City 66160, USA.
Johnson
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Rozman
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KK
D000284:Administration, Oral; D000818:Animals; D001835:Body Weight / Q000187:drug effects; D004971:Estrus / Q000187:drug effects*; D005260:Female; D009929:Organ Size / Q000187:drug effects; D010053:Ovary / Q000187:drug effects; D010060:Ovulation / Q000187:drug effects*; D000072317:Polychlorinated Dibenzodioxins / Q000008:administration & dosage / Q000633:toxicity*; D011897:Random Allocation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012098:Reproduction / Q000187:drug effects
D000072317:Polychlorinated Dibenzodioxins