Antiviral activity of S-7HNa on the infectivity and replication of herpes simplex virus type 1 in cultured cells.
The effect of sodium salt of the acid related to ester S-7 (i.e. S-7HNa) on the infectivity and replication of herpes simplex virus type 1 in Vero cultured cells was studied. S-7HNa, at the highest concentration lacking cytotoxicity (10 mM), produced, at various inocula, a 70% inhibition of HSV-1 infectivity with respect to the plaque formation detected in control infected cultures. This inhibitory activity was substantiated by studies on progeny production. S-7HNa revealed a therapeutic index higher than that of the correlative ester (S-7).
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Institute of Microbiology, University of Genoa, Italy.
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D000818:Animals; D000998:Antiviral Agents / Q000494:pharmacology*; D002522:Chlorocebus aethiops; D006561:Herpes Simplex / Q000382:microbiology; D018259:Herpesvirus 1, Human / Q000187:drug effects* / Q000472:pathogenicity / Q000502:physiology; D008826:Microbial Sensitivity Tests; D011743:Pyrimidines / Q000494:pharmacology*; D014709:Vero Cells; D014779:Virus Replication / Q000187:drug effects*
D000998:Antiviral Agents; D011743:Pyrimidines; C026625:ethyl-2-methylthio-4-methyl-5-pyrimidine carboxylate