Secondary organ allografting after a primary "bridging" xenotransplant.
It remains uncertain whether xenotransplantation can sensitize the recipient to alloantigens, rendering subsequent allotransplantation unsuccessful. This is of considerable importance if a xenograft is to be used as a "bridge" to support the patient until a suitable allograft becomes available. When sera from 9 baboons that had received pig or African green monkey heart or liver xenografts were tested against a panel of lymphocytes from 5 or 6 potential donor baboons, positivity was seen in only 1 baboon (and then to only 2 of the potential 5 donors). In 4 baboons that had undergone previous xenotransplants (1 from this series of 9 baboons and 3 others), subsequent organ allografting was not followed by hyperacute, antibody-mediated, or accelerated cellular rejection. We conclude that organ xenotransplantation using discordant or concordant donor species does not prohibit subsequent allotransplantation.
Ye
Y
Y
Oklahoma Transplantation Institute, Oklahoma University Health Sciences Center, Oklahoma City 73112, USA.
Luo
Y
Y
Kobayashi
T
T
Taniguchi
S
S
Li
S
S
Niekrasz
M
M
Kosanke
S
S
Baker
J
J
Mieles
L
L
Smith
D
D
D000818:Animals; D002522:Chlorocebus aethiops; D006084:Graft Rejection / Q000517:prevention & control; D006085:Graft Survival / Q000276:immunology; D016027:Heart Transplantation / Q000276:immunology*; D006650:Histocompatibility Testing; D007519:Isoantigens / Q000276:immunology*; D016031:Liver Transplantation / Q000276:immunology*; D008214:Lymphocytes / Q000276:immunology; D010215:Papio; D013552:Swine; D014183:Transplantation, Heterologous; D014184:Transplantation, Homologous
D007519:Isoantigens