title: Transient reduction of autoantibodies against oxidized LDL in patients with acute myocardial infarction.
abstract: Fifteen consecutive patients (mean age 66 +/- 14, range 31-82) with an acute myocardial infarction (MI) suitable for thrombolytic therapy were included in this study. Autoantibodies against oxidized low-density lipoprotein (LDL) were determined by enzyme-linked immunosorbent assay (ELISA). Patients (n = 10) with marked elevation of the MB isoenzyme of creatinine kinase (CK-MB)-mass had significant decreases of oLDL-Ab during the acute phase, with a minimum after 8 h following the onset of thrombolytic therapy (within-group significance: p < .001; between groups: p = .01). Patients (n = 5) with CK-MB-mass values less than 70 ng/ml did not show this phenomenon. Furthermore, significant correlations existed between CK-MB-mass and oLDL-Ab after 6 and 8 h (n = 15; r = .72; p = .003) and the time of the highest CK-MB-mass values (after 12 h) and the time of the maximal decrease of oLDL-Ab (after 8 h) (r = .74; p = .003). Our observations provide further evidence for the release of free radicals and for increased lipid peroxidation during reperfusion after prolonged ischemia. The decrease of oLDL-Ab appears to be a marker for the severity of MI.
authors.affiliation: Department of Internal Medicine, University of Graz, Austria.
authors.forename: M
authors.initials: M
authors.lastname: Schumacher
authors.forename: B
authors.initials: B
authors.lastname: Eber
authors.forename: F
authors.initials: F
authors.lastname: Tatzber
authors.forename: P
authors.initials: P
authors.lastname: Kaufmann
authors.forename: G
authors.initials: G
authors.lastname: Halwachs
authors.forename: F M
authors.initials: FM
authors.lastname: Fruhwald
authors.forename: R
authors.initials: R
authors.lastname: Zweiker
authors.forename: H
authors.initials: H
authors.lastname: Esterbauer
authors.forename: W
authors.initials: W
authors.lastname: Klein
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D001323:Autoantibodies / Q000097:blood*; D003402:Creatine Kinase / Q000097:blood; D005260:Female; D006801:Humans; D007527:Isoenzymes; D007700:Kinetics; D008077:Lipoproteins, LDL / Q000276:immunology*; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000201:enzymology / Q000276:immunology*; D010084:Oxidation-Reduction
chemical_list: D001323:Autoantibodies; D007527:Isoenzymes; D008077:Lipoproteins, LDL; D003402:Creatine Kinase