Ribozymes: biology, biochemistry, and implications for clinical medicine.
Ribozymes are a class of ribonucleic acid (RNA) molecules that possess enzymatic properties. Upon binding to complementary nucleic acid strands, catalytic degradation takes place via a cleavage reaction. In effect, inactivation of susceptible substrate RNA molecules takes place at a catalytic rate and with a high degree of substrate specificity. This article reviews the biology and biochemistry of this class of molecules and its potential applications in clinical medicine.
Kiehntopf
M
M
Universitätsklinikum Rudolf Virchow, Berlin, Germany.
Esquivel
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EL
Brach
M A
MA
Herrmann
F
F
D015316:Genetic Therapy; D016337:RNA, Catalytic / Q000502:physiology* / Q000627:therapeutic use
D016337:RNA, Catalytic