title: Nerve root infiltration and sympathetic block. An experimental study of intraradicular blood flow.
abstract: METHODS
  The nerve root of L7 was exposed, and a clamp was applied to simulate radiculopathy. Intraradicular blood flow was measured at the takeoff point of the nerve root and at the distal to the dorsal root ganglion before and after nerve root infiltration with 2% lidocaine or physiological saline solution (control group), or sympathetic ganglion block with 2% lidocaine.
  
  
  OBJECTIVE
  To investigate one of the mechanisms of the therapeutic effect of nerve root infiltration by assessing changes in intraradicular blood flow.
  
  
  BACKGROUND
  Increased intraradicular blood flow was noted both proximal and distal to the clamp after nerve root infiltration or sympathetic ganglion block with 2% lidocaine. No increase was seen after nerve root infiltration with saline solution. Macroscopic and microscopic examination showed that dye after nerve root infiltration did not spread beyond the clamped region to the proximal site.
  
  
  METHODS
  Intraradicular blood flow was measured with a tissue blood flowmeter using the electrolytic hydrogen clearance method before and after nerve root infiltration with 2% lidocaine or physiologic saline solution (control group), or sympathetic ganglion block with 2% lidocaine.
  
  
  RESULTS
  Increased intraradicular blood flow was noted both proximal and distal to the clamp after nerve root infiltration or sympathetic ganglion block with 2% lidocaine. No increase was seen after nerve root infiltration with saline solution.
  
  
  CONCLUSIONS
  An increase in intraradicular blood flow is related to one of the mechanisms of the therapeutic effect of nerve root infiltration. This effect may be mediated by the sympathetic nervous system.
authors.affiliation: Department of Orthopaedic Surgery, Fukushima Medical College, Fukushima, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Yabuki
authors.forename: S
authors.initials: S
authors.lastname: Kikuchi
mesh_terms: D000818:Animals; D001340:Autonomic Nerve Block / Q000379:methods*; D004396:Coloring Agents / Q000493:pharmacokinetics; D004285:Dogs; D005728:Ganglia, Sympathetic / Q000187:drug effects; D008012:Lidocaine / Q000494:pharmacology; D008161:Lumbosacral Region / Q000098:blood supply / Q000294:innervation; D012039:Regional Blood Flow / Q000187:drug effects; D013126:Spinal Nerve Roots / Q000098:blood supply* / Q000187:drug effects
chemical_list: D004396:Coloring Agents; D008012:Lidocaine