Haemolytic disease of the newborn due to anti-M.
A patient with haemolytic disease of the newborn (HDN) due to anti-M which required exchange transfusion is described. Anti-M antibodies are usually assumed to be naturally occurring and to consist of immunoglobulin M (IgM); many however have an immunoglobin G (IgG) component. In view of this and the described occurrence of HDN, recommendations are made regarding the management of a pregnancy in which anti-M antibodies are detected.
Duguid
J K
JK
Mersey and North Wales Regional Transfusion Service, Liverpool, UK.
Bromilow
I M
IM
Entwistle
G D
GD
Wilkinson
R
R
D000328:Adult; D004899:Erythroblastosis, Fetal / Q000097:blood* / Q000628:therapy; D005078:Exchange Transfusion, Whole Blood; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007518:Isoantibodies / Q000097:blood*; D008951:MNSs Blood-Group System / Q000276:immunology*; D011247:Pregnancy; D011248:Pregnancy Complications
D007518:Isoantibodies; D008951:MNSs Blood-Group System