title: Localization of transforming growth factor-beta type I and type II receptors in mouse development.
abstract: We have investigated the localization pattern of the transforming growth factor-beta (TGF-beta) receptors type I (T beta R-I) and type II (T beta R-II) during mouse organogenesis by immunohistochemical analysis. Staining of both receptors was found in many developing organs, e.g., bone, teeth, Meckel's cartilage, and neural tissues, where the expression of their ligands has been previously reported. During the investigated stages, expression of T beta R-I was more ubiquitous than that of T beta R-II. T beta R-II preferentially localized in the undifferentiated mesenchymal cells which subsequently differentiated into bone. There was no staining of T beta R-II in the central nervous system, while intense T beta R-I staining was found specifically in nervous tissues. Expression of T beta R-I and T beta R-II was mostly coincident with that of their ligands, suggesting that TGF-beta s act as multiple mediators during organogenesis. In addition, colocalization of both receptors in the epithelia of the tooth bud and submandibular gland, which were actively invaginating into the mesenchyme, leads us to speculate that both receptors may be necessary for dynamic epithelial morphogenesis.
authors.affiliation: Department of Oral Pathology, Tokushima University School of Dentistry, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Iseki
authors.forename: N
authors.initials: N
authors.lastname: Osumi-Yamashita
authors.forename: K
authors.initials: K
authors.lastname: Miyazono
authors.forename: P
authors.initials: P
authors.lastname: Franzén
authors.forename: H
authors.initials: H
authors.lastname: Ichijo
authors.forename: H
authors.initials: H
authors.lastname: Ohtani
authors.forename: Y
authors.initials: Y
authors.lastname: Hayashi
authors.forename: K
authors.initials: K
authors.lastname: Eto
mesh_terms: D030201:Activin Receptors, Type I; D000818:Animals; D005314:Embryonic and Fetal Development; D007150:Immunohistochemistry; D051379:Mice; D017346:Protein Serine-Threonine Kinases; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II; D018125:Receptors, Transforming Growth Factor beta / Q000378:metabolism*
chemical_list: D018125:Receptors, Transforming Growth Factor beta; D017346:Protein Serine-Threonine Kinases; D030201:Activin Receptors, Type I; D000077293:Receptor, Transforming Growth Factor-beta Type I; D000077294:Receptor, Transforming Growth Factor-beta Type II