title: [Eradication of asymptomatic carrier state of non-typhoid Salmonella with two doses of pefloxacin].
abstract: BACKGROUND
  The carrier state of Salmonella may represent a source of contamination for other people. Its treatment is unsatisfactory so that a carrier may shed organisms for numerous months.
  
  
  METHODS
  From 1990 to 1993, 17 children aged 1.5 months to 8 years were seen because they were asymptomatic carriers of non-typhoid Salmonella, confirmed by three successive stool cultures. All had presented earlier acute severe infection having required treatment with amoxicillin (13 cases) and ceftriaxone or cefotaxime (four cases). They were given one dose of pefloxacin, 12 mg/kg, 4 to 8 weeks after the initial episode. This unique dose was administered again 4 days later. Stool cultures were performed before the first administration and 10, 30, 45 and 60 days after, with a last control 3 to 4 months later.
  
  
  RESULTS
  Eradication of the Salmonella was obtained by the 10th day in 13 patients and within the 3 following weeks in 2 others. Those children who excreted a few number of organisms were early eradicated while the 2 patients who did not respond to pefloxacin shed larger number of bacteria. There was no side-effects of treatment.
  
  
  CONCLUSIONS
  A short treatment with pefloxacin appears to be effective and safe in eradicating the carrier state when stool excretion of Salmonella is moderate.
authors.affiliation: Département de pédiatrie, hôpital Saint-Vincent-de-Paul, Paris, France.
authors.forename: D
authors.initials: D
authors.lastname: Gendrel
authors.forename: J
authors.initials: J
authors.lastname: Raymond
authors.forename: F
authors.initials: F
authors.lastname: Moulin
authors.forename: F
authors.initials: F
authors.lastname: Habib
authors.forename: J L
authors.initials: JL
authors.lastname: Iniguez
authors.forename: M
authors.initials: M
authors.lastname: Chemillier-Truong
authors.forename: J
authors.initials: J
authors.lastname: Badoual
mesh_terms: D002353:Carrier State / Q000188:drug therapy*; D002648:Child; D002675:Child, Preschool; D004334:Drug Administration Schedule; D006801:Humans; D007223:Infant; D015366:Pefloxacin / Q000008:administration & dosage* / Q000627:therapeutic use; D012475:Salmonella / Q000145:classification; D012480:Salmonella Infections / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D015366:Pefloxacin
vernacular_title: Eradication du portage asymptomatique des salmonelles non typhoïdiques par deux doses péfloxacine.