Decreases of CD4- and CD8-positive T lymphocytes in retired chromate workers.
To investigate the effects of chromates on the human immune system, we measured total T lymphocytes and their two major subpopulations (CD4+ and CD8+ T lymphocytes) in the peripheral blood of 19 retired male workers who had been exposed to chromate at a chemical plant. The results indicated that both CD4+ and CD8+ T lymphocytes were significantly decreased, resulting in decreases in total T lymphocytes and total lymphocytes.
Tanigawa
T
T
Department of Public Health, Faculty of Medicine, University of Tokyo, Japan.
Araki
S
S
Araki
T
T
Minato
N
N
Yokoyama
K
K
D000328:Adult; D015496:CD4-Positive T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D018414:CD8-Positive T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism; D016022:Case-Control Studies; D002617:Chemical Industry; D002840:Chromates / Q000009:adverse effects* / Q000276:immunology; D006801:Humans; D007564:Japan / Q000453:epidemiology; D008175:Lung Neoplasms / Q000517:prevention & control; D018655:Lymphocyte Count / Q000187:drug effects / Q000528:radiation effects; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D012179:Retirement
D002840:Chromates