Glomerulonephritis after human parvovirus infection in homozygous sickle-cell disease.
Glomerulonephritis with proteinuria of sufficient degree to manifest the nephrotic syndrome followed aplastic crises induced by human parvovirus (B19) in seven patients with homozygous sickle-cell disease, within 7 days in five patients and 6-7 weeks in two. Segmental proliferative glomerulonephritis was found in all four patients who underwent acute renal biopsies and focal segmental glomerulosclerosis was found in the fifth patient who had a biopsy 4 months later. One patient recovered completely, one died in chronic renal failure after 3 months, and the others had impaired creatinine clearance, four with continuing proteinuria.
Wierenga
K J
KJ
MRC Laboratories, Jamaica.
Pattison
J R
JR
Brink
N
N
Griffiths
M
M
Miller
M
M
Shah
D J
DJ
Williams
W
W
Serjeant
B E
BE
Serjeant
G R
GR
D000293:Adolescent; D000328:Adult; D000755:Anemia, Sickle Cell / Q000150:complications / Q000235:genetics*; D000914:Antibodies, Viral / Q000032:analysis; D001706:Biopsy; D002648:Child; D004279:DNA, Viral / Q000032:analysis; D016731:Erythema Infectiosum / Q000150:complications*; D005260:Female; D005923:Glomerulosclerosis, Focal Segmental / Q000209:etiology* / Q000473:pathology; D006720:Homozygote; D006801:Humans; D007668:Kidney / Q000473:pathology; D008297:Male; D009404:Nephrotic Syndrome / Q000209:etiology; D016732:Parvovirus B19, Human / Q000235:genetics / Q000276:immunology; D011507:Proteinuria / Q000209:etiology
D000914:Antibodies, Viral; D004279:DNA, Viral