Purine nucleotide metabolism in lymphocytes of B-cell chronic lymphocytic leukemia patients.
Purine nucleotides were studied in human peripheral blood lymphocytes from normal subjects and patients with chronic B-cell lymphocytic leukemia (B-CLL). Nucleotide content was determined by high performance liquid chromatography (HPLC). The overall rate of purine nucleotide synthesis was measured following the incorporation of 14C-formate into the nucleotides of a lymphocytic suspension. Results indicate a substantially reduced rate of purine nucleotide metabolism.
Tabucchi
A
A
Istituto di Biochimica e di Enzimologia, Università di Siena, Italy.
Carlucci
F
F
Leoncini
R
R
Vannoni
D
D
Consolmagno
E
E
Marinello
E
E
Pizzichini
M
M
Dispensa
E
E
Pagani
R
R
D000368:Aged; D000369:Aged, 80 and over; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism*; D008875:Middle Aged; D011685:Purine Nucleotides / Q000378:metabolism*
D011685:Purine Nucleotides