Susceptibility of Guyanan Saimiri monkeys to a chloroquine-sensitive and a chloroquine-resistant strain of Plasmodium vivax from Papua New Guinea.
Attempts were made to infect splenectomized Guyanan Saimiri sciureus monkeys with the following Papua New Guinean strains of Plasmodium vivax: AMRU-1, a chloroquine-resistant strain; and AMRU-2, a chloroquine-sensitive strain. Inoculation of 7 monkeys with the AMRU-1 strain, 4 using blood-stage parasites and 3 using sporozoites, all failed to produce infections. Inoculation of 4 monkeys with the AMRU-2 strain, 3 using blood-stage parasites and 1 using sporozoites, were all successful in establishing infections. The results suggest that Guyanan Saimiri are refractory to infection with the AMRU-1 strain. If refractoriness occurs in other species and subspecies of Saimiri monkeys, then studies on the AMRU-1 strain of P. vivax may be restricted to work using Aotus monkeys.
Cooper
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RD
Army Malaria Research Unit, Liverpool Military Area, NSW, Australia.
D000818:Animals; D000852:Anopheles / Q000469:parasitology; D001029:Aotus trivirgatus; D002738:Chloroquine / Q000494:pharmacology*; D004195:Disease Models, Animal; D004351:Drug Resistance; D007303:Insect Vectors / Q000469:parasitology; D016780:Malaria, Vivax / Q000276:immunology / Q000469:parasitology*; D010219:Papua New Guinea; D018512:Parasitemia / Q000276:immunology / Q000469:parasitology; D010966:Plasmodium vivax / Q000187:drug effects* / Q000276:immunology; D012453:Saimiri / Q000469:parasitology*; D012692:Serial Passage; D013156:Splenectomy
D002738:Chloroquine