title: Auditory brain-stem responses evoked by electrical stimulation of the cochlear nucleus in human subjects.
abstract: When auditory nerve function is lost due to surgical removal of bilateral acoustic tumors, a sense of hearing may be restored by means of an auditory brain-stem implant (ABI), which electrically stimulates the auditory pathway at the level of the cochlear nucleus. Placement of the stimulating electrodes during surgical implantation may be aided by electrically evoked auditory brain-stem responses (EABRs) recorded intra-operatively. To establish preliminary standards for human EABRs evoked by electrical stimulation of the cochlear nucleus, short-latency evoked potentials were recorded from 6 ABI patients who were either already implanted or undergoing implantation surgery. Neural responses were distinguished from stimulus artifact and equipment artifact by their properties during stimulus polarity reversal and amplitude variation. Other properties contributed to further identification of the evoked potentials as auditory responses (EABRs). The response waveforms generally had 2 or 3 waves. The peak latencies of these waves (approximately 0.3, 1.3, and 2.2 msec) and the brain-stem localization of the region from which they could be elicited are consistent with auditory brain-stem origin.
authors.affiliation: Electrophysiology Laboratory, House Ear Institute, Los Angeles, CA 90057, USA.
authors.forename: M D
authors.initials: MD
authors.lastname: Waring
mesh_terms: D000328:Adult; D003054:Cochlear Implants; D017626:Cochlear Nucleus / Q000502:physiology*; D004558:Electric Stimulation; D016057:Evoked Potentials, Auditory, Brain Stem; D006801:Humans; D010524:Peripheral Nervous System Neoplasms / Q000601:surgery