title: Human cerebrovascular nerve fibers immunoreactive for synaptophysin, chromogranin A and tyrosine hydroxylase.
abstract: The innervation of human cerebral blood vessels has been examined using synaptophysin, a marker of synaptic vesicles, and chromogranin A, a marker of large dense-core vesicles. The catecholaminergic marker tyrosine hydroxylase was used for comparison. Synaptophysin and tyrosine hydroxylase demonstrated a similar distribution of nerve fibers whereas chromogranin A terminals were only sparsely evident. Our results suggest that there is not a subset of nerve fibers in existence which has a distribution different than that of catecholaminergic fibers. Furthermore, in view of its unexpected sparse distribution, chromogranin A in the nervi vasorum is not likely to be a significant contributor to cerebral blood flow regulation.
authors.affiliation: University of Western Ontario, Faculty of Medicine, London, Canada.
authors.forename: K L
authors.initials: KL
authors.lastname: Kaye
authors.forename: D G
authors.initials: DG
authors.lastname: Munoz
mesh_terms: D000328:Adult; D001808:Blood Vessels / Q000294:innervation*; D001921:Brain / Q000098:blood supply*; D002560:Cerebrovascular Circulation; D053379:Chromogranin A; D002864:Chromogranins / Q000276:immunology / Q000378:metabolism*; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008875:Middle Aged; D009412:Nerve Fibers / Q000276:immunology / Q000378:metabolism*; D016708:Synaptophysin / Q000276:immunology / Q000378:metabolism*; D014446:Tyrosine 3-Monooxygenase / Q000276:immunology / Q000378:metabolism*; D014711:Vertebral Artery / Q000378:metabolism
chemical_list: C506150:CHGA protein, human; D053379:Chromogranin A; D002864:Chromogranins; D016708:Synaptophysin; D014446:Tyrosine 3-Monooxygenase