title: Opposite effects of angiotensin II and nitric oxide on neurons in the duck subfornical organ.
abstract: Angiotensin II (ANGII) is known to activate neurons in the subfornical organ (SFO) of mammals and birds and this activation is regarded as the basis for the ANGII induced increase in water intake. Application of the nitric oxide (NO) donor sodium nitroprusside inhibited the activity in 10 out of 12 duck SFO neurons, 8 of which were in addition excited by ANGII. These data, in combination with the histochemical detection of NO synthase in the duck SFO, demonstrate the involvement of NO in SFO mediated responses and might represent the cellular basis for the observed opposite effects of ANGII and NO on water intake.
authors.affiliation: Max-Planck-Institut für Physiologische und Klinische Forschung, W.G. Kerckhoff-Institut, Bad Nauheim, Germany.
authors.forename: H A
authors.initials: HA
authors.lastname: Schmid
authors.forename: F
authors.initials: F
authors.lastname: Schäfer
authors.forename: E
authors.initials: E
authors.lastname: Simon
mesh_terms: D000804:Angiotensin II / Q000494:pharmacology*; D000818:Animals; D002452:Cell Count; D004305:Dose-Response Relationship, Drug; D004372:Ducks / Q000502:physiology*; D005260:Female; D008297:Male; D009474:Neurons / Q000187:drug effects*; D009569:Nitric Oxide / Q000494:pharmacology*; D009599:Nitroprusside / Q000494:pharmacology; D013356:Subfornical Organ / Q000187:drug effects*
chemical_list: D000804:Angiotensin II; D009599:Nitroprusside; D009569:Nitric Oxide