title: Discriminant function using red cell indices to distinguish between HbC and HbE traits.
abstract: Values for MCV, MCH, MCHC and red cell distribution width (RDW) derived from subjects with HbC and HbE traits using a Technicon H*1 automated blood count analyser were compared. Significantly higher MCH, MCHC and RDW values were found in those with HbC trait. By use of a simple discriminant function (MCHC2 x RDW/1000), 19/20 subjects with HbC trait gave a value > or = 16.3, and 20/21 subjects with HbE trait gave a value < or = 16.2. The function described may be of value as an adjunct to electrophoresis in intralaboratory quality control.
authors.affiliation: Section of Paediatric Haematology, University of Sheffield Department of Paediatrics, Children's Hospital, Western Bank, UK.
authors.forename: R F
authors.initials: RF
authors.lastname: Hinchliffe
authors.forename: S P
authors.initials: SP
authors.lastname: Ellis
authors.forename: J S
authors.initials: JS
authors.lastname: Lilleyman
mesh_terms: D000328:Adult; D001772:Blood Cell Count; D002648:Child; D002675:Child, Preschool; D003937:Diagnosis, Differential; D016002:Discriminant Analysis; D004909:Erythrocyte Indices; D005260:Female; D006444:Hemoglobin C / Q000032:analysis* / Q000235:genetics; D006446:Hemoglobin E / Q000032:analysis* / Q000235:genetics; D006456:Hemoglobinuria / Q000097:blood / Q000175:diagnosis* / Q000235:genetics; D006801:Humans; D007223:Infant; D008297:Male
chemical_list: D006444:Hemoglobin C; D006446:Hemoglobin E