title: Synthesis and evaluation of aminoadamantane derivatives for in vitro anti-HIV and antitumor activities.
abstract: The synthesis of a series of 2-aminobenzimidazole and indole amide derivatives containing the adamantyl moiety is described. The compounds, evaluated for in vitro anti-HIV and antitumor activities, were found to be moderately active or inactive, versus drug-treated controls, used for comparison purposes.
authors.affiliation: Dipartimento di Scienze Farmaceutiche, Università di Pisa.
authors.forename: A
authors.initials: A
authors.lastname: da Settimo
authors.forename: A M
authors.initials: AM
authors.lastname: Marini
authors.forename: G
authors.initials: G
authors.lastname: Primofiore
authors.forename: F
authors.initials: F
authors.lastname: Da Settimo
mesh_terms: D000218:Adamantane / Q000031:analogs & derivatives* / Q000737:chemistry / Q000494:pharmacology; D000970:Antineoplastic Agents / Q000737:chemistry* / Q000494:pharmacology; D000998:Antiviral Agents / Q000737:chemistry* / Q000494:pharmacology; D001562:Benzimidazoles / Q000737:chemistry* / Q000494:pharmacology; D002460:Cell Line; D004353:Drug Evaluation, Preclinical; D004354:Drug Screening Assays, Antitumor; D006678:HIV / Q000187:drug effects*; D006801:Humans; D015394:Molecular Structure; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D000998:Antiviral Agents; D001562:Benzimidazoles; C027391:2-aminobenzimidazole; D000218:Adamantane