[Induced modifications of liver cytochrome P-450 levels as a function of age in rats].
In this paper we showed age effect on hepatic level of cytochrome P-450. We discussed effects of inductors on this hemoprotein also. Cytochrome P-450 content increased to 1-month of life, but decreased to 4-month. In the oldest rats cytochrome P-450 increased again. Content of this hemoprotein was induced by phenobarbital and beta-naphthoflavone in all examined groups, especially strong in young animals. Induction effect of dexamethasone was observed in 4-20-month of life.
Plewka
A
A
II Katedra Histologii i Embriologii Slaskiej Akademii Medycznej w Katowicach.
Plewka
D
D
Kamiński
M
M
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001571:Benzoflavones / Q000494:pharmacology; D003577:Cytochrome P-450 Enzyme System / Q000187:drug effects / Q000378:metabolism*; D003907:Dexamethasone / Q000494:pharmacology; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D010634:Phenobarbital / Q000494:pharmacology; D051381:Rats; D019324:beta-Naphthoflavone
D001571:Benzoflavones; D019324:beta-Naphthoflavone; D003907:Dexamethasone; D003577:Cytochrome P-450 Enzyme System; D010634:Phenobarbital
Induktorowe modyfikacje poziomu watrobowego cytochromu P-450 w funkcji wieku szczura.