Myocardial ischemia induced by topical use of 5-fluorouracil.
An 85-year-old woman, with known stable angina pectoris, was prescribed 5-fluorouracil cream to treat a small basal cell carcinoma on the forehead. Half an hour after application the patient developed her typical ischemic pain which persisted for 2 hours. Rechallenge, during hospitalization, resulted in recurrence of symptoms that were effectively controlled with sublingual isosorbide dinitrate. Prophylactic therapy with nitroglycerin patch enabled further use of the 5-fluorouracil cream for the next month.
Rozenman
Y
Y
Department of Cardiology, Hadassah University Hospital, Ein Kerem, Jerusalem, Israel.
Gurewich
J
J
Gotsman
M S
MS
D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000787:Angina Pectoris / Q000188:drug therapy; D002280:Basal Cell Carcinoma / Q000188:drug therapy*; D004359:Drug Therapy, Combination; D005153:Facial Neoplasms / Q000188:drug therapy*; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage / Q000009:adverse effects*; D006801:Humans; D007547:Isosorbide / Q000627:therapeutic use; D017202:Myocardial Ischemia / Q000139:chemically induced* / Q000188:drug therapy; D005996:Nitroglycerin / Q000627:therapeutic use
D005996:Nitroglycerin; D005472:Fluorouracil; D007547:Isosorbide