title: Follicular fluid insulin-like growth factor-I and insulin-like growth factor-II concentrations vary as a function of day 3 serum follicle stimulating hormone.
abstract: We determined follicular fluid concentrations of insulin-like growth factor (IGF)-I, IGF-II and inhibin as a function of day 3 serum follicle stimulating hormone (FSH) in 16 women undergoing follicular fluid aspiration in preparation for in-vitro fertilization and embryo transfer. Follicular fluid concentrations of IGF-I and IGF-II were significantly less in the 'low' FSH group as compared to the 'high' FSH group. The mean IGF-I concentration was 67.6 ng/ml [confidence intervals (CI) 51.6-92.5] in the 'low' FSH group compared to 87.1 ng/ml (CI 72.8-104.2; P < 0.025) in the 'high' FSH group. Mean IGF-II concentrations were 354.8 ng/ml (CI 297.8-422.9) in the 'low' FSH group compared to 489.8 ng/ml (CI 384.6-624.5; P < 0.05) in the 'high' FSH group. Follicular fluid inhibin concentrations did not differ between groups. These differences in follicular fluid IGF as a function of day 3 FSH may raise questions regarding the role growth factors play in the physiological processes of the ageing follicle.
authors.affiliation: Department of Obstetrics and Gynecology, Brown University School of Medicine, Women and Infants Hospital, Providence, RI 02905, USA.
authors.forename: D B
authors.initials: DB
authors.lastname: Seifer
authors.forename: L C
authors.initials: LC
authors.lastname: Giudice
authors.forename: B A
authors.initials: BA
authors.lastname: Dsupin
authors.forename: R V
authors.initials: RV
authors.lastname: Haning
authors.forename: G N
authors.initials: GN
authors.lastname: Frishman
authors.forename: H G
authors.initials: HG
authors.lastname: Burger
mesh_terms: D000328:Adult; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000097:blood*; D015571:Follicular Fluid / Q000378:metabolism*; D006801:Humans; D007265:Inhibins / Q000032:analysis*; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D007335:Insulin-Like Growth Factor II / Q000032:analysis*; D010062:Ovulation Induction
chemical_list: D007265:Inhibins; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D005640:Follicle Stimulating Hormone