title: Two polyamine analogs (BE-4-4-4 and BE-4-4-4-4) directly affect growth, survival, and cell cycle progression in two human brain tumor cell lines.
abstract: 1,14-Bis-(ethyl)-amino-5,10-diazatetradecane N1,N11-bis(ethyl)norspermine (BE-4-4-4) and 1,19-bis-(ethylamino)-5,10,15 triazanonadecane (BE-4-4-4-4) are two relatively new polyamine analogs synthesized for use as antineoplastic agents. In human brain tumor cell lines U-251 MG and SF-767, both agents inhibited cell growth, were cytotoxic, induced a variable G1/S block, and depleted intracellular polyamines. Since intracellular polyamine depletion did not always correlate with growth inhibition, cell survival, or cell cycle progression, it cannot completely explain the effects of these agents on growth, survival, and cell cycle progression in U-251 MG and SF-767 cells.
authors.affiliation: Department of Neurological Surgery, School of Medicine, University of California, San Francisco 94143, USA.
authors.forename: C J
authors.initials: CJ
authors.lastname: Bergeron
authors.forename: H S
authors.initials: HS
authors.lastname: Basu
authors.forename: L J
authors.initials: LJ
authors.lastname: Marton
authors.forename: D F
authors.initials: DF
authors.lastname: Deen
authors.forename: M
authors.initials: M
authors.lastname: Pellarin
authors.forename: B G
authors.initials: BG
authors.lastname: Feuerstein
mesh_terms: D000970:Antineoplastic Agents / Q000494:pharmacology*; D001932:Brain Neoplasms / Q000188:drug therapy*; D005434:Flow Cytometry; D006131:Growth Inhibitors / Q000494:pharmacology*; D006801:Humans; D013096:Spermine / Q000031:analogs & derivatives* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
chemical_list: D000970:Antineoplastic Agents; D006131:Growth Inhibitors; C058306:N(1),N(14)-bis(ethyl)homospermine; C082768:BE 4-4-4-4; D013096:Spermine