title: [Bronchial reactivity after regular inhalation of salbutamol].
abstract: 15 patients with mild bronchial asthma were selected for study. They inhaled salbutamol 2.5 mg three times daily for 8 days. Bronchodilator dose-response studies were performed by administering increasing doses of isuprel intravenously before and after treatment with salbutamol. Histamine provocation was done to estimate airway responsiveness. That was performed prior to and after salbutamol therapy. Regular inhaled salbutamol increased airway responsiveness to histamine--Pc20 was significantly reduced from 1.95 mg/ml--before treatment to 0.44 mg/ml--after salbutamol therapy. The bronchodilatory effect after isuprel was the same before and after treatment with salbutamol.
authors.affiliation: Katedry i Kliniki Chorób Wewnetrznych i Alergologii AM we Wrocłlawiu.
authors.forename: J
authors.initials: J
authors.lastname: Małlolepszy
authors.forename: M
authors.initials: M
authors.lastname: Krasnowska
authors.forename: E
authors.initials: E
authors.lastname: Passowicz-Muszyńska
mesh_terms: D000280:Administration, Inhalation; D000328:Adult; D000420:Albuterol / Q000008:administration & dosage*; D001249:Asthma / Q000188:drug therapy*; D001985:Bronchial Provocation Tests; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D007545:Isoproterenol / Q000008:administration & dosage; D008297:Male; D012123:Pulmonary Ventilation / Q000187:drug effects; D013147:Spirometry
chemical_list: D007545:Isoproterenol; D000420:Albuterol
vernacular_title: Reaktywność oskrzeli po regularnych inhalacjach salbutamolu.