A new neuronal cell protecting substance, lavanduquinocin, produced by Streptomyces viridochromogenes.
A new neuronal cell protecting substance, lavanduquinocin was isolated from Streptomyces viridochromogenes 2942-SVS3. It consists of a carbazole skeleton with an ortho quinone function and a cyclolavandulyl moiety. Lavanduquinocin protected neuronal hybridoma N18-RE-105 cells from L-glutamate toxicity with EC50 value 15.5 nm.
Shin-Ya
K
K
Institute of Cellular and Molecular Biosciences, University of Tokyo, Japan.
Shimizu
S
S
Kunigami
T
T
Furihata
K
K
Furihata
K
K
Seto
H
H
D000818:Animals; D002227:Carbazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002478:Cells, Cultured; D005285:Fermentation; D018698:Glutamic Acid / Q000633:toxicity; D051379:Mice; D015394:Molecular Structure; D051381:Rats; D011916:Rats, Inbred F344; D013302:Streptomyces
D002227:Carbazoles; C095334:lavanduquinocin; D018698:Glutamic Acid