title: Reversible blockade, induced by the neurotoxin MPTP, of corticofugal impulse activity to neurons of the caudate nucleus in cats.
abstract: It has been demonstrated in acute experiments in cats anesthetized with nembutal and immobilized with ditilin [succinylcholine iodide--Translator] that the number of neurons of the caudate nucleus responding to a single stimulation of the motor cortex with action potentials with a latent period less than 8.0 msec in the first 10-12 days after a course of injections of MPTP (5 mg/kg daily for 5 days, intramuscularly) decreased significantly as compared with the control. Their number is gradually restored by the 45th-54th day after the administration of the neurotoxin. A one-time injection of the dopaminomimetic, apomorphine (5 mg/kg, intramuscularly), also significantly decreases the number of neurons with a latent period of the responses less than 8.0 msec for 5 h in the intact animals, and is incapable of removing the blockade of the corticoneostriatal impulse activity in animals with an MPTP-induced dopamine deficit. The hypothesis is advanced that dopamine exerts a protective inhibitory influence on the conduction of corticofugal glutamatergic impulse activity to neurons of the neostriatum.
authors.affiliation: Department of the Physiology of the Cerebral Cortex and Subcortical Structures, A. A. Bogomolets Institute of Physiology, Academy of Sciences of Ukraine, Kiev.
authors.forename: N N
authors.initials: NN
authors.lastname: Oleshko
mesh_terms: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine / Q000494:pharmacology*; D000200:Action Potentials / Q000187:drug effects; D000818:Animals; D001058:Apomorphine / Q000494:pharmacology; D002415:Cats; D002421:Caudate Nucleus / Q000187:drug effects / Q000502:physiology*; D002540:Cerebral Cortex / Q000187:drug effects / Q000502:physiology*; D004298:Dopamine / Q000502:physiology; D004558:Electric Stimulation; D008297:Male; D009474:Neurons / Q000187:drug effects*; D009435:Synaptic Transmission / Q000187:drug effects*
chemical_list: D015632:1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; D001058:Apomorphine; D004298:Dopamine