S fimbriae of uropathogenic Escherichia coli bind to primary human renal proximal tubular epithelial cells but do not induce expression of intercellular adhesion molecule 1.
We have recently reported an increase of expression of the intercellular adhesion molecule 1 by renal carcinoma cells in response to S fimbriae of Escherichia coli. Now we demonstrate that E. coli expressing S and P fimbriae strongly binds to human proximal tubular epithelial cells. However, in primary and simian virus 40-transfected renal tubular epithelial cells S fimbriae do not enhance the expression of intercellular adhesion molecule 1.
Kreft
B
B
Klinik für Innere Medizin, Medizinischen Universität zu Lübeck, Germany.
Placzek
M
M
Doehn
C
C
Hacker
J
J
Schmidt
G
G
Wasenauer
G
G
Daha
M R
MR
van der Woude
F J
FJ
Sack
K
K
D001422:Bacterial Adhesion; D004848:Epithelium / Q000382:microbiology; D004926:Escherichia coli / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology*; D010861:Fimbriae, Bacterial / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D007371:Interferon-gamma / Q000494:pharmacology; D007687:Kidney Tubules, Proximal / Q000382:microbiology*; D014552:Urinary Tract Infections / Q000382:microbiology*
D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma