title: [Histologic and immunohistochemical profiles of benign granular cell tumors. Report of 41 cases].
abstract: Since the descriptions of << myoblastomas >>, later denominated granular cell tumours, many immunohistological and ultrastructural studies have been undertaken with the aim of establishing their histogenesis. Now the hypothesis of a neurogenic origin appears clear. From the large number of cases (53) diagnosed in Geneva over a period of 10 years, we decided to do a retrospective study of these tumours with regard to their immunohistological phenotypes, using the following markers: S100 protein (S100), Neuron specific enolase (NSE), Vimentin, Chromogranin, Glial fibrillary acidic protein (GFAP), Keratin, Epithelial membrane antigen (EMA), Desmin, Smooth muscle alpha actin. 100% of tumours were positive for S100, and 90% for NSE, which confirms the neurogenic origin. 70% were Vimentin positive, with however a variable intensity. All the other markers were negative. Immunohistological staining for S100 and NSE may be useful tool in the diagnosis of these tumours.
authors.affiliation: Institut et Département Universitaires de Pathologie de Lausanne, Suisse.
authors.forename: K
authors.initials: K
authors.lastname: Weber-Chappuis
authors.forename: J J
authors.initials: JJ
authors.lastname: Widmann
authors.forename: Y
authors.initials: Y
authors.lastname: Kapanci
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D016586:Granular Cell Tumor / Q000737:chemistry / Q000473:pathology*; D006801:Humans; D007124:Immunoenzyme Techniques; D008297:Male; D008875:Middle Aged; D010751:Phosphopyruvate Hydratase / Q000032:analysis; D012189:Retrospective Studies; D009418:S100 Proteins / Q000032:analysis; D014746:Vimentin / Q000032:analysis
chemical_list: D009418:S100 Proteins; D014746:Vimentin; D010751:Phosphopyruvate Hydratase
vernacular_title: Profils histologique et immunohistochimique des tumeurs bénignes à cellules granuleuses. A propos de 41 cas.