[Severe acquired protein S deficiency with thrombophlebitis after febrile infection in a 7-year-old girl].
The importance of the anticoagulant properties of protein S is illustrated by the high incidence of thromboembolic events in individuals with protein S-deficiency. A 7 year old girl was hospitalized with purpura-like bruises and lesions on both thighs after she had suffered from febrile infection. A subsequently developing thrombosis of the left V. femoralis was treated successfully with urokinase. Haemostaseological investigations showed no signs of disseminated intravascular coagulation. However, isolated severe degradation or all protein S-components due to the presence of a circulating autoantibody to protein S was found. After several months the antibody was detectable not any more, activity and antigens of protein S were normal.
Lutze
G
G
Institut für Klinische Chemie der Otto-von-Guericke-Universität Magdeburg.
Hartung
K J
KJ
Aumann
V
V
Mittler
U
U
Luley
C
C
D001424:Bacterial Infections / Q000097:blood* / Q000150:complications; D001780:Blood Coagulation Tests; D002352:Carrier Proteins / Q000097:blood; D002648:Child; D005260:Female; D005500:Follow-Up Studies; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects; D006801:Humans; D016167:Integrin alphaXbeta2; D010644:Phenprocoumon / Q000008:administration & dosage; D018455:Protein S Deficiency / Q000097:blood* / Q000188:drug therapy; D015912:Thrombolytic Therapy; D013924:Thrombophlebitis / Q000097:blood* / Q000188:drug therapy; D014568:Urokinase-Type Plasminogen Activator / Q000008:administration & dosage / Q000009:adverse effects
D002352:Carrier Proteins; D016167:Integrin alphaXbeta2; D006493:Heparin; D014568:Urokinase-Type Plasminogen Activator; D010644:Phenprocoumon
Schwerer erworbener Protein S-Mangel mit Beinvenenthrombose nach fieberhaftem Infekt bei einem 7jährigen Mdchen.