Aspergillus keratitis after radial keratotomy.
OBJECTIVE
A case of severe Aspergillus keratitis after radial keratotomy manifested as a discrete midstromal infiltrate along a radial incision. Despite aggressive treatment with topical amphotericin B and oral itraconazole, the patient required a therapeutic penetrating keratoplasty.


CONCLUSIONS
Histopathologic examination disclosed a corneal ulcer with numerous septate, branching hyphae throughout the stroma, and marked stromal necrosis. Aspergillus species should be included among the microbial pathogens responsible for infectious keratitis after radial keratotomy. If infectious keratitis is suspected, comprehensive cultures for bacteria and fungi should be obtained.
Heidemann
D G
DG
Department of Ophthalmology, William Beaumont Hospital, USA.
Dunn
S P
SP
Watts
J C
JC
D000666:Amphotericin B / Q000627:therapeutic use; D001228:Aspergillosis / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D001232:Aspergillus fumigatus / Q000302:isolation & purification*; D003315:Cornea / Q000382:microbiology / Q000473:pathology; D003320:Corneal Ulcer / Q000382:microbiology* / Q000473:pathology / Q000628:therapy; D015821:Eye Infections, Fungal / Q000209:etiology* / Q000473:pathology / Q000628:therapy; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000627:therapeutic use; D015948:Keratoplasty, Penetrating; D007646:Keratotomy, Radial / Q000009:adverse effects*; D008826:Microbial Sensitivity Tests; D008875:Middle Aged
D017964:Itraconazole; D000666:Amphotericin B