A novel gamma-aminobutyric acid response in the embryonic brainstem as revealed by voltage-sensitive dye recording.
Using a multiple-site optical recording technique employing a fast voltage-sensitive dye, we found a novel type of gamma-aminobutyric acid (GABA) response, which is insensitive to GABAA and GABAB antagonists, but is stimulated by either GABAA or GABAB agonist. This evidence was identified in the early embryonic brainstem slice preparation.
Momose-Sato
Y
Y
Department of Physiology, Tokyo Medical and Dental University School of Medicine, Japan.
Sato
K
K
Sakai
T
T
Hirota
A
A
Kamino
K
K
D000818:Animals; D001418:Baclofen / Q000031:analogs & derivatives / Q000494:pharmacology; D001933:Brain Stem / Q000196:embryology*; D002642:Chick Embryo; D004396:Coloring Agents; D004594:Electrophysiology / Q000379:methods; D018755:GABA Agonists / Q000494:pharmacology; D018756:GABA Antagonists / Q000494:pharmacology; D066298:In Vitro Techniques; D010852:Picrotoxin / Q000494:pharmacology; D005680:gamma-Aminobutyric Acid / Q000378:metabolism*
D001418:Baclofen; D004396:Coloring Agents; D018755:GABA Agonists; D018756:GABA Antagonists; D010852:Picrotoxin; D005680:gamma-Aminobutyric Acid; C057491:2-hydroxysaclofen