The effect of tropisetron injected into the nucleus accumbens septi on ethanol consumption in rats.
Earlier studies have shown that 5-HT3 antagonists possess properties of reducing ethanol (EtOH) preference and intake in EtOH high-preferring rats. In this study we examined the effect of tropisetron (ICS 205-930) microinjection (1 and 10 ng) into the nucleus accumbens septi (NAS) on EtOH drinking in a scheduled access to EtOH paradigm. Control rats received vehicle only. Tropisetron, when injected bilaterally into the NAS, significantly reduced EtOH intake in EtOH high-preferring animals. It is concluded that 5-HT3 antagonists might exert their antipreference activity by influencing the receptors within the NAS and that 5-HT3 receptors might play an important role in reinforcing properties of EtOH.
Jankowska
E
E
Department of Pharmacology and Physiology of the Nervous System, Institute of Psychiatry and Neurology, Warszawa, Poland.
Kostowski
W
W
D000428:Alcohol Drinking; D000818:Animals; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008845:Microinjections; D009714:Nucleus Accumbens / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012702:Serotonin Antagonists / Q000494:pharmacology; D000077526:Tropisetron
D007211:Indoles; D012702:Serotonin Antagonists; D000077526:Tropisetron