An experimental model to investigate the dynamics of wound contraction.
An excisional wound model in the Hooded Lister rat is described. The methods used to inflict, measure and characterise the process of wound contraction are comprehensively discussed. The model is shown to be reliable, reproducible and capable of detecting the effect of systemically administered prednisolone.
Cross
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Postgraduate School of Studies in Pharmacology, Department of Biomedical Sciences, University of Bradford, UK.
Naylor
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Coleman
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Teo
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D000818:Animals; D005260:Female; D006168:Guinea Pigs; D008297:Male; D008954:Models, Biological; D011239:Prednisolone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000473:pathology; D014945:Wound Healing / Q000187:drug effects / Q000502:physiology*
D011239:Prednisolone