[New data on clinico-morphological heterogeneity of chronic glomerulonephritis].
Many years' experience in studying chronic glomerulonephritis allows the author to consider it to be a group entity including mesangioproliferative, mesangiocapillary and sclerosing (fibroplastic) types of glomerulonephritis. Minimal changes, focal segmental glomerular sclerosis/hyalinosis, membranous nephropathy which have been previously included to a group of chronic glomerulonephritis should be excluded since they comprise another group of non-inflammatory glomerulopathies with primary podocytic damage. A group of mesangioproliferative glomerulonephritis (MPGN) is heterogeneous both in terms of pathogenetic parameters, on the one hand, and clinical and predictive parameters, on the other. Their clinical and morphological variants which differ with the nature of immunoglobulins in the glomerular immune complexes are presented as IgA-, IgM-, and IgG-MPGN, each of them pretends to an individual nosological entity. Mesangiocapillary glomerulonephritis (MCGN) as a nosological entity showing specific features of morphological, pathogenetic, and clinical manifestations and prognosis may be left only if dense deposit diseases are deducted, which owing to clinical, morphological and some pathogenetic features pretends to its independence. The morphological types of MCGN are either types (I and III) or form phases (I and IV) which reflect the progression of the disease. Sclerosing (fibroplastic) glomerulonephritis is an evolutive form which completes both MPGN and MCGN. There is strong evidence for the fact that the current nephrology concepts of nosological entities require reconsideration on the basis of new research findings.
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D000936:Antigen-Antibody Complex; D002908:Chronic Disease; D003937:Diagnosis, Differential; D005921:Glomerulonephritis / Q000145:classification* / Q000175:diagnosis / Q000473:pathology*; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D007668:Kidney / Q000276:immunology / Q000473:pathology; D007674:Kidney Diseases / Q000175:diagnosis / Q000276:immunology / Q000473:pathology; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D012106:Research
D000936:Antigen-Antibody Complex; D007136:Immunoglobulins
Novye dannye o kliniko-morfologicheskoĭ geterogennosti khronicheskogo glomerulonefrita.