title: Possible predictive markers of immunotherapy in esophageal cancer: retrospective analysis of a randomized study. The Cooperative Study Group for Esophageal Cancer in Japan.
abstract: The aim of this report is to evaluate retrospectively the data from a prospective randomized study of 158 esophageal cancer patients who actually completed therapy with protein-bound polysaccharide P (PSK) and the 5-year survivals with and without raised alpha 1-antichymotrypsin and sialic acid levels to determine the value of these parameters in predicting effectiveness of immunotherapy. There was a significant difference in survival between the patients with and without PSK therapy. The survival of the radiochemotherapy plus PSK group treated for > 3 months was significantly better than that of the radiochemotherapy group. Among the patients with abnormal levels of alpha 1-antichymotrypsin and sialic acid, those who received PSK may have a significantly better survival than those without PSK. These results indicate that the preoperative serum levels of alpha 1-antichymotrypsin and sialic acid may possibly predict the effectiveness of immunotherapy using PSK.
authors.affiliation: Department of Surgery II, Tokai University, Kanagawa, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Ogoshi
authors.forename: H
authors.initials: H
authors.lastname: Satou
authors.forename: K
authors.initials: K
authors.lastname: Isono
authors.forename: T
authors.initials: T
authors.lastname: Mitomi
authors.forename: M
authors.initials: M
authors.lastname: Endoh
authors.forename: M
authors.initials: M
authors.lastname: Sugita
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000903:Antibiotics, Antineoplastic / Q000627:therapeutic use*; D014408:Biomarkers, Tumor / Q000097:blood*; D003131:Combined Modality Therapy; D004938:Esophageal Neoplasms / Q000097:blood* / Q000276:immunology / Q000628:therapy*; D005260:Female; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D007167:Immunotherapy; D008297:Male; D008875:Middle Aged; D019158:N-Acetylneuraminic Acid; D011237:Predictive Value of Tests; D011509:Proteoglycans / Q000627:therapeutic use*; D012189:Retrospective Studies; D012794:Sialic Acids / Q000097:blood; D000514:alpha 1-Antichymotrypsin / Q000097:blood
chemical_list: D000903:Antibiotics, Antineoplastic; D014408:Biomarkers, Tumor; D007155:Immunologic Factors; D011509:Proteoglycans; D012794:Sialic Acids; D000514:alpha 1-Antichymotrypsin; C010770:polysaccharide-K; D019158:N-Acetylneuraminic Acid