Synthesis and biological evaluation of 6-carboxy-3,4-methanoprolines, new rigid glutamate analogs.
6-Carboxy-3,4-methanoprolines were prepared by reacting ethyl diazoacetate with the suitable 3,4-didehydroproline derivative in the presence of rhodium(II)acetate dimer as catalyst. The affinities of the title compounds for displacement of receptor binding to ionotropic and metabotropic (mGluR1 alpha) glutamate receptors were also determined.
Marinozzi
M
M
Istituto di Chimica Farmaceutica e Tecnica Farmaceutica, Università degli Studi di Perugia, Italy.
Natalini
B
B
Ni
M H
MH
Costantino
G
G
Pellicciari
R
R
Thomsen
C
C
D000818:Animals; D002460:Cell Line; D018698:Glutamic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D015394:Molecular Structure; D051381:Rats; D017470:Receptors, Glutamate / Q000187:drug effects
D017470:Receptors, Glutamate; D018698:Glutamic Acid