title: Further evidence of a dose-response threshold for haloperidol in psychosis.
abstract: OBJECTIVE
  The authors' goal was to determine whether higher doses of haloperidol improve antipsychotic response.
  
  
  METHODS
  During a 2-week, double-blind, randomized fixed-dose study, 24 psychotic patients were given 4, 10, or 40 mg/day of haloperidol.
  
  
  RESULTS
  No clinically relevant difference between groups in favor of the higher antipsychotic doses could be detected.
  
  
  CONCLUSIONS
  Doses of 4 mg/day of haloperidol appear to be as effective as higher doses in the treatment of psychosis.
authors.affiliation: Department of Psychiatry, Southwestern Medical Center, University of Texas, Dallas, USA.
authors.forename: C K
authors.initials: CK
authors.lastname: Stone
authors.forename: D L
authors.initials: DL
authors.lastname: Garve
authors.forename: J
authors.initials: J
authors.lastname: Griffith
authors.forename: J
authors.initials: J
authors.lastname: Hirschowitz
authors.forename: J
authors.initials: J
authors.lastname: Bennett
mesh_terms: D000328:Adult; D004305:Dose-Response Relationship, Drug; D004311:Double-Blind Method; D004334:Drug Administration Schedule; D005260:Female; D006220:Haloperidol / Q000008:administration & dosage / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D011569:Psychiatric Status Rating Scales; D011618:Psychotic Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D012559:Schizophrenia / Q000175:diagnosis / Q000188:drug therapy; D016896:Treatment Outcome
chemical_list: D006220:Haloperidol