Cell-cycle checkpoints. Keeping mitosis in check.
Mutations in an essential yeast gene, encoding DNA polymerase epsilon, abolish the dependence of mitosis on the completion of DNA replication, suggesting that the replication complex provides the checkpoint signal.
Humphrey
T
T
Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
Enoch
T
T
D000818:Animals; D004257:DNA Polymerase II; D004261:DNA Replication / Q000502:physiology*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology; D012568:Schizosaccharomyces / Q000235:genetics / Q000502:physiology
D004257:DNA Polymerase II; D004259:DNA-Directed DNA Polymerase