title: Skeletal alkaline phosphatase as a serum marker of bone metastases in the follow-up of patients with breast cancer.
abstract: Immunoradiometric determination of the bone isoenzyme of alkaline phosphatase with a method provided by Hybritech Inc., San Diego CA (USA) was carried out in 145 female patients, 97 of whom with radically operated breast cancer and 48 with benign mammary cysts, in order to evaluate the correlation of serum levels with the metabolic process of bone rearrangement in patients with bone metastases. This study shows that skeletal ALP, having high specificity (86.48%) and sensitivity (78.6%) for early progression (the average anticipation time compared to scintigraphic detection was 101 days) could represent a valid marker for bone metastases in association with mucinous markers in the follow-up of patients operated for breast cancer. In addition, dynamic serum determination of skeletal ALP could be a valid help in monitoring the efficacy of therapy in patients with bone progression.
authors.affiliation: Department of Experimental Medicine, University La Sapienza, Roma, Italy.
authors.forename: M G
authors.initials: MG
authors.lastname: Reale
authors.forename: D
authors.initials: D
authors.lastname: Santini
authors.forename: G G
authors.initials: GG
authors.lastname: Marchei
authors.forename: A
authors.initials: A
authors.lastname: Manna
authors.forename: A
authors.initials: A
authors.lastname: Del Nero
authors.forename: V
authors.initials: V
authors.lastname: Bianco
authors.forename: P
authors.initials: P
authors.lastname: Marchei
authors.forename: L
authors.initials: L
authors.lastname: Frati
mesh_terms: D000469:Alkaline Phosphatase / Q000097:blood*; D000951:Antigens, Neoplasm / Q000097:blood; D015295:Antigens, Tumor-Associated, Carbohydrate / Q000097:blood; D014408:Biomarkers, Tumor / Q000097:blood*; D001859:Bone Neoplasms / Q000175:diagnosis* / Q000201:enzymology / Q000556:secondary; D001842:Bone and Bones / Q000000981:diagnostic imaging / Q000201:enzymology*; D001943:Breast Neoplasms / Q000175:diagnosis / Q000473:pathology*; D016022:Case-Control Studies; D018450:Disease Progression; D005069:Evaluation Studies as Topic; D005260:Female; D005348:Fibrocystic Breast Disease / Q000175:diagnosis; D006801:Humans; D015592:Immunoradiometric Assay; D007527:Isoenzymes / Q000097:blood*; D018396:Mucin-1 / Q000097:blood; D011446:Prospective Studies; D011877:Radionuclide Imaging; D012189:Retrospective Studies; D012680:Sensitivity and Specificity
chemical_list: D000951:Antigens, Neoplasm; D015295:Antigens, Tumor-Associated, Carbohydrate; D014408:Biomarkers, Tumor; C090797:CA 27-29 antigen; D007527:Isoenzymes; D018396:Mucin-1; C057387:mucinous carcinoma-associated antigen; D000469:Alkaline Phosphatase