title: Failure of pristinamycin treatment in a case of pneumococcal pneumonia.
abstract: A case of pneumonia caused by Streptococcus pneumoniae occurring in a patient receiving pristinamycin is reported. Despite empirical treatment with pristinamycin, 2 g/day for five days, the patient's condition worsened. Protected brush specimen and blood cultures permitted isolation of Streptococcus pneumoniae. MIC testing indicated that the strain was susceptible to pristinamycin and resistant to erythromycin and penicillin. Streptococcus pneumoniae was eradicated by cefotaxime, and pneumonia resolved. This case underlines the fact that pristinamycin may not be suitable for the treatment of multiresistant pneumococcal infections.
authors.affiliation: Laboratoire de Microbiologie A, Centre Hospitalier Universitaire La Milétrie, Poitiers, France.
authors.forename: C
authors.initials: C
authors.lastname: Burucoa
authors.forename: T
authors.initials: T
authors.lastname: Pasdeloup
authors.forename: C
authors.initials: C
authors.lastname: Chapon
authors.forename: J L
authors.initials: JL
authors.lastname: Fauchère
authors.forename: R
authors.initials: R
authors.lastname: Robert
mesh_terms: D000368:Aged; D004352:Drug Resistance, Microbial; D018432:Drug Resistance, Multiple; D005260:Female; D006801:Humans; D008826:Microbial Sensitivity Tests; D011018:Pneumonia, Pneumococcal / Q000188:drug therapy* / Q000503:physiopathology; D013296:Streptococcus pneumoniae / Q000187:drug effects; D017211:Treatment Failure; D014769:Virginiamycin / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D014769:Virginiamycin