title: A comparison of plasma metabolite levels in goats and sheep during continuous low-level administration of fenbendazole.
abstract: Plasma levels of fenbendazole (FBZ) and its sulphoxide (OFZ) and sulphone (FBZ.SO2) metabolites were measured in goats and sheep during low-level administration of FBZ given by intraruminal infusion or formulated into a urea-molasses feed supplement block (UMB). In experiment 1, 6 goats and 6 sheep were offered UMB containing 0.5 g FBZ/kg (MUMB) and individual block consumption was measured daily for 18 days. In experiment 2, some of the same animals (n = 4 for each species) received FBZ by intraruminal infusion at 1, 1.5 and 3 mg/kg liveweight per day for 7 days at each dosage. FBZ, OFZ and FBZ.SO2 levels were determined in plasma collected every 3 days in experiment 1 and on days 4, 5 and 6 of each infusion period in experiment 2. In both experiments, higher equilibrium levels were observed for the three metabolites in sheep than in goats. Significant linear relationships were observed between the daily FBZ dosages and the plasma levels of the three metabolites in both species. The regression coefficients were significantly higher in sheep than in goats for FBZ and OFZ but not for FBZ.SO2, and they were also significantly higher during MUMB administration than during infusion for all three metabolites in both species. FBZ is a suitable anthelmintic for incorporation into a MUMB formulation for use in livestock production systems where responses to molasses urea supplementation have been demonstrated and gastrointestinal parasitism impairs productivity. The results indicate that target dose rates for goats should be 0.75 mg/kg per day compared with 0.5 mg/kg per day for sheep.
authors.affiliation: CSIRO Division of Animal Health, Pastoral Research Laboratory, Armidale, NSW, Australia.
authors.forename: M R
authors.initials: MR
authors.lastname: Knox
authors.forename: J W
authors.initials: JW
authors.lastname: Steel
authors.forename: D N
authors.initials: DN
authors.lastname: Ali
authors.forename: L F
authors.initials: LF
authors.lastname: Le Jambre
mesh_terms: D000042:Absorption; D000821:Animal Feed; D000818:Animals; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D004333:Drug Administration Routes / Q000662:veterinary; D016503:Drug Delivery Systems; D005273:Fenbendazole / Q000008:administration & dosage / Q000493:pharmacokinetics*; D006041:Goats / Q000378:metabolism*; D008297:Male; D012417:Rumen / Q000378:metabolism; D012756:Sheep / Q000378:metabolism*
chemical_list: D005273:Fenbendazole