Calcitriol analogs cause differentiation of neoplastic cells in culture.
Several investigators are developing calcitriol (DHCC, Compound A) derivatives which have less effect on mineral metabolism and are effective in causing differentiation of neoplastic cells. In the present study we investigated three new DHCC derivatives (Compounds B, C, D) for differentiation inducing effect in human neoplastic cell lines HL-60 and U-937.
Srivastava
M D
MD
Department of Biochemistry, State University of New York at Buffalo, USA.
Ambrus
J L
JL
Uskokovic
M R
MR
D002117:Calcitriol / Q000031:analogs & derivatives* / Q000494:pharmacology*; D002454:Cell Differentiation / Q000187:drug effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000473:pathology; D016403:Lymphoma, Large B-Cell, Diffuse / Q000473:pathology; D014407:Tumor Cells, Cultured
D002117:Calcitriol