title: Selective type IV collagen defects in the urothelial basement membrane in interstitial cystitis.
abstract: OBJECTIVE
  The study sought to identify changes in the urothelial basement membrane (UBM) associated with interstitial cystitis (IC).
  
  
  METHODS
  Immunohistochemical assessment of bladder biopsies from IC patients and controls was compared with clinical and histologic findings.
  
  
  RESULTS
  Selective decreases or loss of type IV collagen staining, but not laminin, were found in the UBM of 5 of 11 IC patients with no change in type IV collagen staining of other bladder wall sites.
  
  
  CONCLUSIONS
  The loss of type IV collagen may represent a primary or secondary event and could alter the UBM's role in permeability, thereby contributing to the pathogenesis of IC in the subset of IC patients exhibiting this change.
authors.affiliation: Department of Immunology, Scripps Research Institute, La Jolla, California 92037-1093, USA.
authors.forename: C B
authors.initials: CB
authors.lastname: Wilson
authors.forename: J
authors.initials: J
authors.lastname: Leopard
authors.forename: R M
authors.initials: RM
authors.lastname: Nakamura
authors.forename: D A
authors.initials: DA
authors.lastname: Cheresh
authors.forename: P C
authors.initials: PC
authors.lastname: Stein
authors.forename: C L
authors.initials: CL
authors.lastname: Parsons
mesh_terms: D000328:Adult; D000368:Aged; D001485:Basement Membrane / Q000737:chemistry* / Q000473:pathology; D003094:Collagen / Q000172:deficiency*; D003556:Cystitis / Q000378:metabolism* / Q000473:pathology; D004848:Epithelium / Q000737:chemistry / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008875:Middle Aged; D001743:Urinary Bladder / Q000737:chemistry* / Q000473:pathology
chemical_list: D003094:Collagen