title: Detection of occupational lead nephropathy using early renal markers.
abstract: Automotive use of leaded gasoline continues to be an important source of occupational exposure to lead in India and other countries. The present study assessed the renal function and markers of early renal damage of 22 mechanics at three automobile garages. Urinary N-acetyl-3-D-glucosaminidase activity and beta-2-microglobulin levels were significantly increased in auto garage mechanics with blood leads of 30-69 micrograms/dL. A significant correlation was observed between blood lead levels and urinary N-acetyl-3-D-glucosaminidase activity but not with urine beta-2-microglobulin levels. A marginal impairment in creatinine clearance was not statistically significant. Urinary N-acetyl-3-D-glucosaminidase activity offers a sensitive monitor of blood lead and renal tubular injury.
authors.affiliation: Food and Drug Toxicology Research Centre, National Institute of Nutrition, Jamai Osmania, Hyderabad, India.
authors.forename: B D
authors.initials: BD
authors.lastname: Kumar
authors.forename: K
authors.initials: K
authors.lastname: Krishnaswamy
mesh_terms: D000328:Adult; D015415:Biomarkers / Q000032:analysis*; D003401:Creatine / Q000097:blood / Q000652:urine; D006596:Hexosaminidases / Q000032:analysis; D006801:Humans; D007668:Kidney / Q000737:chemistry* / Q000187:drug effects*; D007674:Kidney Diseases / Q000139:chemically induced* / Q000378:metabolism; D007854:Lead / Q000097:blood / Q000633:toxicity*; D008297:Male; D008875:Middle Aged; D016273:Occupational Exposure / Q000009:adverse effects*; D001613:beta 2-Microglobulin / Q000032:analysis
chemical_list: D015415:Biomarkers; D001613:beta 2-Microglobulin; D007854:Lead; D006596:Hexosaminidases; D003401:Creatine