Fluconazole is removed by continuous venovenous hemofiltration in a liver transplant patient.
Fluconazole is effective for the treatment of fungal infections. A continuous venovenous hemofiltration (CVVH) was necessary in a liver transplant patient with anuria. Fluconazole treatment was started after the diagnosis of systemic candidiasis. There was no adverse effect on liver function, and the immunosuppression with cyclosporine was not affected. It is shown for the first time that CVVH effectively removes fluconazole from the blood circulation by a clearance into the hemofiltrate of approximately 21 ml/min. These data suggest that the treatment of fungal infections with fluconazole does not necessitate a reduction of the dosage during CVVH.
Scholz
J
J
Department of Anesthesiology, University Hospital Eppendorf, Hamburg, Germany.
Schulz
M
M
Steinfath
M
M
Höver
S
S
Bause
H
H
D001002:Anuria / Q000150:complications / Q000628:therapy; D002177:Candidiasis / Q000150:complications / Q000188:drug therapy; D002939:Ciprofloxacin / Q000627:therapeutic use; D016572:Cyclosporine / Q000627:therapeutic use; D015725:Fluconazole / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D006440:Hemofiltration; D006801:Humans; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged; D014640:Vancomycin / Q000627:therapeutic use
D002939:Ciprofloxacin; D014640:Vancomycin; D016572:Cyclosporine; D015725:Fluconazole