DD-peptidases and beta-lactamases: catalytic mechanisms and specificities.
DD-peptidases and beta-lactamases share several common properties, including the formation of an acylenzyme intermediate in their catalytic pathways. In their interactions with beta-lactam antibiotics, the stability of this intermediate is much higher with the peptidases than with the beta-lactamases. The structural factors responsible for this difference have not been identified. The evolution of beta-lactamases is taking place before our eyes, since mutants are constantly selected which can hydrolyze the molecules newly introduced as "beta-lactamase resistant" in the chemotherapeutic arsenal.
Galleni
M
M
Laboratoire d'Enzymologie, Université de Liège, Sart Tilman, Belgium.
Raquet
X
X
Lamotte-Brasseur
J
J
Fonzé
E
E
Amicosante
G
G
Frère
J M
JM
D000595:Amino Acid Sequence; D002384:Catalysis; D008969:Molecular Sequence Data; D002267:Muramoylpentapeptide Carboxypeptidase / Q000378:metabolism*; D011487:Protein Conformation; D013379:Substrate Specificity; D001618:beta-Lactamases / Q000378:metabolism*
D002267:Muramoylpentapeptide Carboxypeptidase; D001618:beta-Lactamases