title: Concentration of pefloxacin in feces during infection prophylaxis in neutropenic patients.
abstract: Pefloxacin (400 mg twice daily) was administered orally for infection prophylaxis in neutropenic patients. Diffusible fecal pefloxacin concentration was determined by bioassay during 24 neutropenic periods. The median diffusible fecal pefloxacin concentration was 187 micrograms/g. This concentration was comparable with those found in volunteers following oral and intravenous administration of pefloxacin (400 mg twice daily) (median of 171 and 155 micrograms/g, respectively). From this study, it is concluded that pefloxacin administered orally results in a predictable high diffusible fecal concentration which leads to effective elimination of susceptible aerobic gram-negative bacilli from the colonic flora.
authors.affiliation: Department of Internal Medicine, Canisius-Wilhelmina Hospital, Nijmegen, The Netherlands.
authors.forename: J J
authors.initials: JJ
authors.lastname: van de Leur
authors.forename: E J
authors.initials: EJ
authors.lastname: Vollaard
authors.forename: A J
authors.initials: AJ
authors.lastname: Janssen
authors.forename: A S
authors.initials: AS
authors.lastname: Dofferhoff
mesh_terms: D000368:Aged; D000970:Antineoplastic Agents / Q000009:adverse effects; D001424:Bacterial Infections / Q000517:prevention & control*; D005243:Feces / Q000737:chemistry* / Q000382:microbiology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006801:Humans; D008875:Middle Aged; D009503:Neutropenia / Q000139:chemically induced / Q000150:complications*; D015366:Pefloxacin / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D000970:Antineoplastic Agents; D015366:Pefloxacin