Familial defective apolipoprotein-B is rare in hypercholesterolaemic South African Afrikaners, coloureds and Indians.
The frequency of familial defective apolipoprotein B-100 (FDB) was assessed among hypercholesterolaemic Afrikaners, coloureds and Indians. Patients selected for screening did not carry any of the founder or common LDL-receptor mutations known to be associated with these groups. No FDB was detected and the mutation is therefore a rare cause of hypercholesterolaemia in these South African populations.
Rubinsztein
D C
DC
Department of Medical Biochemistry, University of Cape Town.
Coetzee
G A
GA
van der Westhuyzen
D R
DR
Langenhoven
E
E
Kotze
M J
MJ
D001055:Apolipoproteins B / Q000097:blood / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D005006:Ethnicity / Q000235:genetics*; D018703:Founder Effect; D006801:Humans; D006938:Hyperlipoproteinemia Type II / Q000097:blood / Q000235:genetics*; D007194:India / Q000208:ethnology; D009154:Mutation / Q000235:genetics; D009426:Netherlands / Q000208:ethnology; D044465:White People / Q000235:genetics*
D001055:Apolipoproteins B