title: [Repeated thrombolysis and difficulties in treatment with antivitamin K in an infant with mitral valve prosthesis].
abstract: The finding of cardiac failure in a neonate led to the diagnosis of congenital mitral regurgitation complicating dystrophic valves. After failed surgical valvuloplasty, the child underwent mitral valve replacement with a Saint-Jude medical prosthesis at the age of 4 months. The child developed four episodes of prosthetic valve thrombosis in the two years that followed. The first was treated surgically but the three others were treated by thrombolysis associating plasminogen tissue activator and urokinase. All but one of the thromboses occurred in a context of recent destabilisation of oral anticoagulant therapy despite the initiation of heparin. Repeat thrombolysis was successfully undertaken, thereby widening the indications of this type of treatment in the infant. This case also underlines the difficulties of oral anticoagulants in infants.
authors.affiliation: Service de cardiologie infantile, CHU de Nancy, hôpital d'enfants, Vandoeuvre-lès-Nancy.
authors.forename: H
authors.initials: H
authors.lastname: Lucron
authors.forename: F
authors.initials: F
authors.lastname: Marçon
authors.forename: G
authors.initials: G
authors.lastname: Bosser
authors.forename: H
authors.initials: H
authors.lastname: Michalski
authors.forename: A M
authors.initials: AM
authors.lastname: Worms
mesh_terms: D015110:4-Hydroxycoumarins; D000925:Anticoagulants / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006350:Heart Valve Prosthesis / Q000009:adverse effects*; D006470:Hemorrhage / Q000209:etiology / Q000628:therapy; D006801:Humans; D007192:Indenes; D007223:Infant; D008943:Mitral Valve; D012008:Recurrence; D015912:Thrombolytic Therapy / Q000009:adverse effects; D013927:Thrombosis / Q000209:etiology / Q000628:therapy*; D014812:Vitamin K / Q000037:antagonists & inhibitors
chemical_list: D015110:4-Hydroxycoumarins; D000925:Anticoagulants; D007192:Indenes; C011664:antivitamins K; D014812:Vitamin K
vernacular_title: Thrombolyse itérative et difficultés du traitement par antivitamine K chez un nourrisson porteur d'une prothèse valvulaire mitrale.