title: Overview and summary: twenty-five-year followup of high-risk children.
abstract: We report a 25-year followup of a group of 50 children at genetic risk for schizophrenia (by virtue of having a parent with the disorder) and 50 matched controls. The children who eventually developed schizophrenia spectrum disorders, including schizophrenia, were identifiable by cognitive-psychophysiological, neurointegrative, and social/personality traits in the preteenage period. The children at risk were also more likely to develop other Axis I disorders, chiefly affective. Moreover, the risk of Axis I disorders was significantly greater among children raised in the group atmosphere of a kibbutz than among those raised in their own nuclear families in cities and towns in Israel. The study is a unique contribution to knowledge of factors underlying the development of psychopathology.
authors.affiliation: NIH/NIMH, Bethesda, MD 20892, USA.
authors.forename: A F
authors.initials: AF
authors.lastname: Mirsky
authors.forename: S
authors.initials: S
authors.lastname: Kugelmass
authors.forename: L J
authors.initials: LJ
authors.lastname: Ingraham
authors.forename: E
authors.initials: E
authors.lastname: Frenkel
authors.forename: M
authors.initials: M
authors.lastname: Nathan
mesh_terms: D000293:Adolescent; D000328:Adult; D000341:Affective Disorders, Psychotic / Q000175:diagnosis / Q000235:genetics / Q000517:prevention & control / Q000523:psychology; D002648:Child; D002668:Child Rearing; D016241:Child of Impaired Parents / Q000523:psychology*; D015331:Cohort Studies; D005260:Female; D006801:Humans; D007557:Israel; D008297:Male; D010553:Personality Development; D012307:Risk Factors; D012559:Schizophrenia / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control; D012565:Schizophrenic Psychology; D012569:Schizotypal Personality Disorder / Q000175:diagnosis / Q000235:genetics* / Q000517:prevention & control / Q000523:psychology; D012931:Social Environment