Safety and pharmacokinetics of vitamin A therapy for infants with respiratory syncytial virus infections.
Infants with respiratory syncytial virus infection have low serum vitamin A levels. We treated 21 respiratory syncytial virus-infected children with 12,500 to 25,000 IU of oral vitamin A. Vitamin A levels were normalized at 6 h, and none of the children experienced vitamin A toxicity or exacerbation of respiratory illness. Vitamin A treatment of previously healthy respiratory syncytial virus-infected infants at these doses is safe and well tolerated.
Neuzil
K M
KM
Department of Medicine, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, USA.
Gruber
W C
WC
Chytil
F
F
Stahlman
M T
MT
Graham
B S
BS
D006801:Humans; D007223:Infant; D018357:Respiratory Syncytial Virus Infections / Q000378:metabolism*; D018113:Respiratory Syncytial Virus, Human; D014801:Vitamin A / Q000009:adverse effects / Q000493:pharmacokinetics*
D014801:Vitamin A