Diadenosine polyphosphates: their biological and pharmacological significance.
Diadenosine polyphosphates are members of a group of dinucleoside polyphosphates that are ubiquitous in bacteria to mammals. In recent years, the diadenosine polyphosphates have received considerable attention in view of their multiple biological activities and potential pharmacological activities. Diadenosine polyphosphates have been identified as modulators of cardiovascular and neurotransmitter-like activities in recent years, besides their previously described role in cell proliferation and as signal molecules when cells are undergoing stress. Diadenosine polyphosphates and their synthetic analogues are being evaluated for their potential as pharmacological agents. This article discusses the various biological functions and physiological significance of the diadenosine polyphosphates.
Baxi
M D
MD
Department of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha 68198-4525, USA.
Vishwanatha
J K
JK
D000818:Animals; D002319:Cardiovascular System / Q000187:drug effects; D002455:Cell Division / Q000187:drug effects; D015226:Dinucleoside Phosphates / Q000096:biosynthesis / Q000378:metabolism* / Q000494:pharmacology*; D018377:Neurotransmitter Agents / Q000378:metabolism
D015226:Dinucleoside Phosphates; D018377:Neurotransmitter Agents; C020733:diadenosine tetraphosphate