I-123 iodoamphetamine lung scanning in patients with ventilation-perfusion mismatching.
I-123 IMP is a nonparticulate agent and becomes trapped by endothelial membranes in the pulmonary capillaries. Using I-123 IMP, the authors studied six patients with ventilation-perfusion mismatch. Three of six patients had pulmonary thromboembolism, and three had pulmonary hypertension. In comparison with conventional perfusion lung scanning using Tc-99m MAA, defect sizes visualized by I-123 IMP were smaller in all patients. I-123 iodoamphetamine is a useful agent for assessing the perfusion of pulmonary arterial microvasculature which Tc-99m MAA fails to penetrate.
Hirose
Y
Y
Department of Radiology, National Cardiovascular Center, Osaka, Japan.
Hayashida
K
K
Ishida
Y
Y
Takamiya
M
M
Nishimura
T
T
D000662:Amphetamines; D005260:Female; D006801:Humans; D006976:Hypertension, Pulmonary / Q000000981:diagnostic imaging*; D007457:Iodine Radioisotopes; D020367:Iofetamine; D008168:Lung / Q000000981:diagnostic imaging*; D008297:Male; D008875:Middle Aged; D011655:Pulmonary Embolism / Q000000981:diagnostic imaging*; D013668:Technetium Tc 99m Aggregated Albumin; D015899:Tomography, Emission-Computed, Single-Photon; D014692:Ventilation-Perfusion Ratio
D000662:Amphetamines; D007457:Iodine Radioisotopes; D013668:Technetium Tc 99m Aggregated Albumin; D020367:Iofetamine