Prognostic significance of laminin production in relation with its receptor expression in human breast carcinomas.
Laminin is a basement membrane glycoprotein whose expression has been widely related to cancer progression. Laminin production by primary breast carcinomas was investigated using immunohistochemistry on archival specimens from a retrospective series with long term follow-up. Laminin production was found to be independent of the clinical and pathological variables analyzed, whereas a statistically significant direct association with the expression of the laminin receptor and a negative association with the differentiation-related antigen Ca-MBr8 were observed. Survival analysis indicated that laminin positivity by itself has no prognostic significance. However, when analyzed together with the laminin receptor expression, laminin was associated with a good prognosis in receptor-negative tumors and with the worst prognosis in receptor-positive tumors.
Pellegrini
R
R
Istituto Nazionale Tumori, Milano, Italy.
Martignone
S
S
Tagliabue
E
E
Belotti
D
D
Bufalino
R
R
Cascinelli
N
N
Ménard
S
S
Colnaghi
M I
MI
D001943:Breast Neoplasms / Q000175:diagnosis / Q000378:metabolism* / Q000401:mortality; D003593:Cytoplasm / Q000737:chemistry; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007150:Immunohistochemistry; D007797:Laminin / Q000096:biosynthesis*; D008875:Middle Aged; D011379:Prognosis; D017474:Receptors, Laminin / Q000096:biosynthesis*; D012189:Retrospective Studies; D015996:Survival Rate
D007797:Laminin; D017474:Receptors, Laminin