title: Allelic variation of apolipoprotein E in Japanese sporadic Creutzfeldt-Jakob disease patients.
abstract: We analyzed apolipoprotein E (apo E) genotypes in 53 Japanese sporadic Creutzfeldt-Jakob disease (CJD) patients and 100 normal controls using the polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) methods. The apo E allelic frequencies in Japanese sporadic CJD patients and our control population were as follows: epsilon 2, 6.6% versus 7.5%; epsilon 3, 82.1% versus 81.5%; epsilon 4, 11.3% versus 11.0%. The mean ages at onset in Japanese sporadic CJD patients were as follows: epsilon 3/epsilon 3, 63.8 years; epsilon 3/epsilon 4, 66.3 years; epsilon 2/epsilon 3, 68.6 years. These results indicate that there is no association between apo E genotype and sporadic CJD in Japan.
authors.affiliation: Department of Neuropathology, Kyushu University, Fukuoka, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Nakagawa
authors.forename: T
authors.initials: T
authors.lastname: Kitamoto
authors.forename: H
authors.initials: H
authors.lastname: Furukawa
authors.forename: K
authors.initials: K
authors.lastname: Ogomori
authors.forename: J
authors.initials: J
authors.lastname: Tateishi
mesh_terms: D000483:Alleles; D001057:Apolipoproteins E / Q000235:genetics*; D007562:Creutzfeldt-Jakob Syndrome / Q000235:genetics*; D004586:Electrophoresis; D005838:Genotype; D006801:Humans; D007564:Japan; D016133:Polymerase Chain Reaction; D015995:Prevalence
chemical_list: D001057:Apolipoproteins E