[Thrombocytopenia in patients with lupus nephritis].
60 patients with lupus nephritis (LN) were examined for frequency of thrombocytopenia, role of IgG and IgM antibodies to cardiolipin (AC), antithrombocytic antibodies (AA) and anaerobic platelet metabolism. Thrombocytopenia occurred in 28 (46.7%) patients, it was 2 times more frequent in active LN patients with AC than in those free of AC. AA were recorded in 36.6% of patients (32.2% versus 37.5% for patients with thrombocytopenia and free of it, respectively). In active LN platelet activity and metabolism became enhanced. Genesis of thrombocytopenia in various LN forms may be induced by different mechanisms.
Tareeva
I E
IE
Kozlovskaia
L V
LV
Kabaenkova
G S
GS
Kozlovskaia
N L
NL
D000293:Adolescent; D000328:Adult; D000368:Aged; D017153:Antibodies, Anticardiolipin / Q000097:blood; D000917:Antibody Formation; D001706:Biopsy; D005260:Female; D005921:Glomerulonephritis / Q000150:complications / Q000276:immunology; D006801:Humans; D007668:Kidney / Q000473:pathology; D007676:Kidney Failure, Chronic / Q000150:complications / Q000276:immunology; D008181:Lupus Nephritis / Q000150:complications* / Q000276:immunology; D008297:Male; D008875:Middle Aged; D009404:Nephrotic Syndrome / Q000150:complications / Q000276:immunology; D013921:Thrombocytopenia / Q000209:etiology* / Q000276:immunology
D017153:Antibodies, Anticardiolipin
Trombotsitopeniia u bol'nykh volchanochnym nefritom.