title: S fimbriae of uropathogenic Escherichia coli bind to primary human renal proximal tubular epithelial cells but do not induce expression of intercellular adhesion molecule 1.
abstract: We have recently reported an increase of expression of the intercellular adhesion molecule 1 by renal carcinoma cells in response to S fimbriae of Escherichia coli. Now we demonstrate that E. coli expressing S and P fimbriae strongly binds to human proximal tubular epithelial cells. However, in primary and simian virus 40-transfected renal tubular epithelial cells S fimbriae do not enhance the expression of intercellular adhesion molecule 1.
authors.affiliation: Klinik für Innere Medizin, Medizinischen Universität zu Lübeck, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Kreft
authors.forename: M
authors.initials: M
authors.lastname: Placzek
authors.forename: C
authors.initials: C
authors.lastname: Doehn
authors.forename: J
authors.initials: J
authors.lastname: Hacker
authors.forename: G
authors.initials: G
authors.lastname: Schmidt
authors.forename: G
authors.initials: G
authors.lastname: Wasenauer
authors.forename: M R
authors.initials: MR
authors.lastname: Daha
authors.forename: F J
authors.initials: FJ
authors.lastname: van der Woude
authors.forename: K
authors.initials: K
authors.lastname: Sack
mesh_terms: D001422:Bacterial Adhesion; D004848:Epithelium / Q000382:microbiology; D004926:Escherichia coli / Q000472:pathogenicity*; D004927:Escherichia coli Infections / Q000382:microbiology*; D010861:Fimbriae, Bacterial / Q000378:metabolism*; D006801:Humans; D066298:In Vitro Techniques; D018799:Intercellular Adhesion Molecule-1 / Q000378:metabolism*; D007371:Interferon-gamma / Q000494:pharmacology; D007687:Kidney Tubules, Proximal / Q000382:microbiology*; D014552:Urinary Tract Infections / Q000382:microbiology*
chemical_list: D018799:Intercellular Adhesion Molecule-1; D007371:Interferon-gamma