title: A dose-ranging study of labetalol in moderate to moderately severe hypertension.
abstract: Labetalol optimal doses for Indonesian patients were investigated in an open, multicentre, unforced titration dose-finding study involving 134 essential hypertensive outpatients with baseline supine DBP (SuDBP) of 105-129 mmHg. Labetalol was started at 50 mg bid and as necessary increased by 50 mg bid every 2 weeks. Evaluable for efficacy were 105 moderate and 25 moderately severe hypertensives. Labetalol was effective (decreased SuDBP to 90 mmHg or less) in 75% of patients and moderately effective (decreased SuDBP at least 10% of baseline but did not reach 90 mmHg) in 10%. The cumulative percent responders were 15, 49, 79 and 85% to final daily doses of 100, 200, 300 and 400 mg, respectively. Adverse reactions were found in 31% of patients, the most frequent were gastrointestinal complaints causing 3 withdrawals. It is concluded that labetalol optimal doses for Indonesian moderate to moderately severe hypertensives range from 100 to 300 mg daily in 2 divided doses.
authors.affiliation: Department of Pharmacology, Medical Faculty, University of Indonesia, Jakarta.
authors.forename: I
authors.initials: I
authors.lastname: Darmansjah
authors.forename: A
authors.initials: A
authors.lastname: Setiawati
authors.forename: P
authors.initials: P
authors.lastname: Prabowo
authors.forename: E
authors.initials: E
authors.lastname: Sukandar
authors.forename: I
authors.initials: I
authors.lastname: Parsoedi
authors.lastname: Ardaya
authors.forename: B
authors.initials: B
authors.lastname: Bahry
authors.forename: J
authors.initials: J
authors.lastname: Jusman
authors.forename: E
authors.initials: E
authors.lastname: Anggraeni
mesh_terms: D000284:Administration, Oral; D000328:Adult; D000368:Aged; D001794:Blood Pressure / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D004342:Drug Hypersensitivity; D005260:Female; D006339:Heart Rate / Q000187:drug effects*; D006801:Humans; D006973:Hypertension / Q000188:drug therapy*; D007214:Indonesia; D007741:Labetalol / Q000008:administration & dosage / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D010045:Outpatients
chemical_list: D007741:Labetalol