title: In vitro activity of RP 59500 (quinupristin/dalfopristin) against antibiotic-resistant strains of Streptococcus pneumoniae and enterococci.
abstract: The activity of RP 59500 (quinupristin/dalfopristin) was evaluated in vitro against antibiotic-resistant strains of Streptococcus pneumoniae (N = 15) and Enterococcus spp. (N = 43). By broth dilution MIC tests RP 59500 was highly active against penicillin-resistant S. pneumoniae and vancomycin-resistant Enterococcus faecium, but showed poor activity against E. faecalis. In time-kill studies the drug was rapidly bactericidal against S. pneumoniae but failed to kill most enterococci, even in the presence of gentamicin or human serum.
authors.affiliation: Division of Infectious Diseases, Medical College of Pennsylvania, Philadelphia 19104, USA.
authors.forename: C C
authors.initials: CC
authors.lastname: Johnson
authors.forename: L
authors.initials: L
authors.lastname: Slavoski
authors.forename: M
authors.initials: M
authors.lastname: Schwartz
authors.forename: P
authors.initials: P
authors.lastname: May
authors.forename: P G
authors.initials: PG
authors.lastname: Pitsakis
authors.forename: A L
authors.initials: AL
authors.lastname: Shur
authors.forename: M E
authors.initials: ME
authors.lastname: Levison
mesh_terms: D004352:Drug Resistance, Microbial; D016983:Enterococcus / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D013296:Streptococcus pneumoniae / Q000187:drug effects*; D014769:Virginiamycin / Q000494:pharmacology*
chemical_list: D014769:Virginiamycin; C062940:quinupristin-dalfopristin