title: Naproxen for 8 days can prevent heterotopic ossification after hip arthroplasty.
abstract: The effect of 1 week of treatment with naproxen on the formation of heterotopic ossification after cemented total hip arthroplasty was studied in a prospective trial. Twenty-seven patients received 500 mg naproxen twice daily for 7 days postoperatively. The medication was started on the morning of the operation. The results were compared with a control group of 23 patients from a previous study who had not received any type of non-steroidal antiinflammatory drug. All radiographs were mixed randomly, and patient identification was blinded. Three months after the operation, heterotopic ossification had developed in 12 (52%) patients in the control group and in 3 (11%) patients in the naproxen-treated group. One year after the operation, 4 (17%) patients in the naproxen-treated group and 12 (52%) in the control group had heterotopic ossification (p < 0.05). Severe ossification developed in 3 patients in the control group and in none in the naproxen-treated group. The authors conclude that naproxen given for 1 week can decrease the incidence of heterotopic ossification after total hip arthroplasty.
authors.affiliation: Department of Orthopedics, Hvidovre Hospital, University of Copenhagen, Denmark.
authors.forename: P
authors.initials: P
authors.lastname: Gebuhr
authors.forename: H
authors.initials: H
authors.lastname: Wilbek
authors.forename: M
authors.initials: M
authors.lastname: Soelberg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004334:Drug Administration Schedule; D006615:Hip / Q000503:physiopathology; D006622:Hip Prosthesis / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D009288:Naproxen / Q000627:therapeutic use*; D009999:Ossification, Heterotopic / Q000209:etiology / Q000517:prevention & control*; D011446:Prospective Studies; D016059:Range of Motion, Articular / Q000502:physiology; D012086:Reoperation; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
chemical_list: D009288:Naproxen