Familial nonmedullary thyroid cancer. An emerging entity that warrants aggressive treatment.
OBJECTIVE
To determine whether familial nonmedullary thyroid carcinoma behaves like sporadic carcinoma of follicular cell origin.


METHODS
Retrospective review.


METHODS
University medical center.


METHODS
Fourteen patients were treated for familial nonmedullary thyroid carcinoma between 1980 and 1994. Thirteen families were identified, with 30 affected individuals.


METHODS
Patients were treated with total or completion total thyroidectomy. Thirteen additional operations were performed to control recurrent disease.


METHODS
Stage, recurrence, and survival. Patients were followed up for a mean of 6.5 years.


RESULTS
In our 14 patients, 13 tumors were multifocal, and six of these were bilateral. The incidences of lymph node metastasis and local invasion were both 57% (n = 8). Seven patients (50%) had recurrences during follow-up.


CONCLUSIONS
Familial nonmedullary thyroid carcinoma has a high incidence of multifocality and invasion and a high rate of local recurrence. Aggressive initial treatment and careful follow-up seem to be indicated.
Grossman
R F
RF
Department of Surgery, Mount Zion Medical Center, University of California at San Francisco, USA.
Tu
S H
SH
Duh
Q Y
QY
Siperstein
A E
AE
Novosolov
F
F
Clark
O H
OH
D000328:Adult; D000368:Aged; D002277:Carcinoma / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D003241:Consanguinity; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D012189:Retrospective Studies; D013964:Thyroid Neoplasms / Q000235:genetics* / Q000473:pathology / Q000601:surgery*; D013965:Thyroidectomy; D016896:Treatment Outcome