Human chorionic gonadotropin supplementation in recurring pregnancy loss: a controlled trial.
OBJECTIVE
To investigate the efficacy of hCG in the management of recurrent early pregnancy loss.


METHODS
A prospective, randomized, controlled trial.


METHODS
Miscarriage Clinic, Women's Hospital, Liverpool, United Kingdom.


METHODS
Eighty-one women attending the miscarriage clinic with idiopathic recurrent pregnancy loss were randomized to receive hCG supplementation or placebo in early pregnancy.


METHODS
The success rate or live birth rate.


RESULTS
In women with regular menstrual cycles it was found that hCG had no beneficial effect, the pregnancy success rate being 86% in both groups. However, women with oligomenorrhea had a pregnancy success rate of 40% in the placebo group but a statistically significant improvement to 86% if hCG was given.


CONCLUSIONS
Human chorionic gonadotropin can be recommended for idiopathic recurrent pregnancy loss in women with oligomenorrhea.
Quenby
S
S
Miscarriage Clinic, Women's Hospital, Liverpool, United Kingdom.
Farquharson
R G
RG
D000026:Abortion, Habitual / Q000150:complications / Q000188:drug therapy*; D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008597:Menstrual Cycle; D009839:Oligomenorrhea / Q000150:complications; D011247:Pregnancy; D011256:Pregnancy Outcome; D011446:Prospective Studies; D012016:Reference Values
D006063:Chorionic Gonadotropin