[The effect of retinoic acid on DNA synthesis of fibroblast in vitro culture].
The effect of retinoic acid on DNA synthesis of fibroblast was studied in vitro culture. The results demonstrated that retinoic acid significantly (P < 0.01) inhibited the DNA synthesis of fibroblast in vitro culture and a dose-dependent relationship between DNA synthesis and retinoic acid concentration was observed. The possible mechanism of retinoic acid used for the treatment of scar was discussed.
Song
W
W
Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing.
Guan
Z
Z
Sun
G
G
D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D014212:Tretinoin / Q000494:pharmacology*
D014212:Tretinoin; D004247:DNA