Cataract classification.
Opacifications of the eye lens--generally defined as cataracts--develop in various different parts of the lens. Therefore, one has to differentiate the types of opacities. For epidemiological studies it is prerequisite to classify the cataracts according to their localization within the lens as well as to the size and intensity of the opacified area. Two approaches have been used in the past: 1) subjective methods of lens observation (based on slit lamp microscopy) and 2) objective methods with measurements of lens transparency or lens opacity respectively based on slit image documentation according to the Scheimpflug principle combined with the retroillumination technique. With ageing, the light transparency of the lens is subjected to considerable changes. Even without the formation of an opacity the transmission of the wavelengths in the UV-B/UV-A and the visible range is diminished. The single lens layers are affected by this phenomenon to different degrees. These changes which might also indicate an early stage of 'cataract formation' cannot be discerned by subjective methods. The densitometric image analysis of Scheimpflug slit images, however, allows the exact measurement of the light scatter in the single lens layers and enables the early recognition of disturbances in transparency which is of crucial importance particularly in cataract epidemiology. In view of our present knowledge the evaluation of risk factors which might be of importance in multifactorial cataract processes will hardly be possible by carrying out prevalence and/or incidence studies involving a single examination of the population. In this case follow-up studies (cohort studies) with repeated examinations are prerequisite. The 'objective methods' for classification alone are able to ensure the necessary reproducibility and the possibility to measure transparency changes in the lens before visible (and therefore subjectively recognizable) opacifications occurred. The methodical procedure with respect to an epidemiological study on the involvement of UV-B radiation in the processes of cataract formation in man requires the application of objective methods for cataract classification.
Hockwin
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Institut für experimentelle Ophthalmologie, Rheinische Friedrich-Wilhelms-Universität, Bonn, Germany.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000375:Aging / Q000502:physiology; D002386:Cataract / Q000145:classification* / Q000209:etiology / Q000473:pathology / Q000503:physiopathology; D002648:Child; D003720:Densitometry / Q000295:instrumentation / Q000379:methods; D006801:Humans; D007223:Infant; D007908:Lens, Crystalline / Q000473:pathology / Q000503:physiopathology / Q000528:radiation effects; D008875:Middle Aged; D012307:Risk Factors; D014466:Ultraviolet Rays / Q000009:adverse effects