Herpes simplex virus vaccines as immunotherapeutic agents.
As persistent viruses can escape immune surveillance, chronic or recurrent disease can be a major problem. Only after nearly 60 years of work have recent reproducible data, using herpes simplex virus infection as a model for persistent viral disease, established that vaccine immunotherapy is effective in the treatment of such viral infections.
Stanberry
L R
LR
Divn of Infectious Diseases, Children's Hospital Research Foundation, University of Cincinnati College of Medicine, OH 45229-3039, USA.
D000818:Animals; D002986:Clinical Trials as Topic; D006168:Guinea Pigs; D006561:Herpes Simplex / Q000628:therapy*; D006801:Humans; D012008:Recurrence; D018139:Simplexvirus / Q000276:immunology*; D014614:Vaccines, Synthetic / Q000627:therapeutic use; D014765:Viral Vaccines / Q000627:therapeutic use*
D014614:Vaccines, Synthetic; D014765:Viral Vaccines