title: Graves' disease in HTLV-I carriers.
abstract: Three carriers of human T-lymphotropic virus type I (HTLV-I) with Graves' disease are reported. All three cases were complicated with uveitis, and one also showed chronic arthropathy. Anti-HLTV-I antibody was found in the serum by the particle agglutination method and western blotting, and HTLV-I proviral DNA was detected in peripheral lymphocytes by the polymerase chain reaction and Southern blotting. HTLV-I is a causal agent of adult T-cell leukemia and HTLV-I associated myelopathy/tropical spastic paraparesis, and is believed to be related to the pathogenesis of diseases such as chronic arthropathy, uveitis, chronic bronchoalveolitis, and Sjögren's syndrome. On the other hand, retrovirus infection is considered to cause autoimmune diseases. Thus, the pathogenesis of Graves' disease in the present patients might be associated with HTLV-I infection.
authors.affiliation: First Department of Internal Medicine, School of Medicine, University of Tokushima, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Kawai
authors.forename: K
authors.initials: K
authors.lastname: Yokoi
authors.forename: M
authors.initials: M
authors.lastname: Akaike
authors.forename: M
authors.initials: M
authors.lastname: Kunishige
authors.forename: M
authors.initials: M
authors.lastname: Abe
authors.forename: Y
authors.initials: Y
authors.lastname: Tanouchi
authors.forename: H
authors.initials: H
authors.lastname: Mine
authors.forename: Y
authors.initials: Y
authors.lastname: Mimura
authors.forename: S
authors.initials: S
authors.lastname: Saito
mesh_terms: D000368:Aged; D000914:Antibodies, Viral / Q000097:blood; D005260:Female; D006111:Graves Disease / Q000097:blood / Q000150:complications*; D015490:HTLV-I Infections / Q000097:blood / Q000150:complications*; D015368:Human T-lymphotropic virus 1 / Q000276:immunology / Q000302:isolation & purification*; D006801:Humans; D008875:Middle Aged; D014605:Uveitis / Q000150:complications
chemical_list: D000914:Antibodies, Viral