Phenotype of glutathione S-transferase Mu (GSTM1) and susceptibility to malignant melanoma. MMM group. Multidisciplinary Malignant Melanoma Group.
The isoenzyme Mu of glutathione S-transferase (GSTM1) is dominantly inherited, and the prevalence of this isoenzyme in the population is about 60%. The lack of GSTM1 has been linked with cancer risk. The frequency of the phenotypes of this isoenzyme in melanoma (MM) patients (n = 197) is reported here. A significantly higher proportion of individuals in the control group (n = 147) had measurable GSTM1 than MM patients (59.1% vs 42%, P = 0.002); there was a higher proportion of positive phenotypes in general among women than among men. Odds ratio analysis indicated that individuals with this polymorphic variant have an approximately 2-fold risk of developing these cancers. GSTM1 phenotype distribution depends on age, smoking habit and tumour pathology. A group of MM patients with dysplastic naevi was also studied.
Lafuente
A
A
Institute de Salut Pública, Universitat de Barcelona, Spain.
Molina
R
R
Palou
J
J
Castel
T
T
Moral
A
A
Trias
M
M
D000328:Adult; D000368:Aged; D000975:Antioxidants / Q000378:metabolism; D005260:Female; D005982:Glutathione Transferase / Q000172:deficiency* / Q000235:genetics* / Q000378:metabolism; D006801:Humans; D007527:Isoenzymes / Q000172:deficiency* / Q000378:metabolism / Q000502:physiology; D008297:Male; D008545:Melanoma / Q000201:enzymology* / Q000209:etiology; D008875:Middle Aged; D009381:Neoplasms, Radiation-Induced / Q000201:enzymology / Q000209:etiology; D010641:Phenotype; D017382:Reactive Oxygen Species / Q000378:metabolism / Q000633:toxicity; D012016:Reference Values; D012307:Risk Factors; D014466:Ultraviolet Rays / Q000009:adverse effects
D000975:Antioxidants; D007527:Isoenzymes; D017382:Reactive Oxygen Species; D005982:Glutathione Transferase