Plasmapheresis and hemodialysis in the treatment of acute renal failure in multiple myeloma.
Two patients with multiple myeloma (IgA-kappa and IgG-lambda) and severe acute renal failure were treated by combined plasmapheresis and hemodialysis. In both patients renal function was restored to normal. The pathogenetic role of M-proteins and the possible mechanisms responsible for renal damage were discussed. While the addition of plasmapheresis has not been shown to extend survival, a reduction in the need for long-term dialysis appears to result from this intervention. It is concluded that the removal of M-proteins by plasmapheresis may be of therapeutic value in multiple myeloma patients.
Kes
P
P
Department of Nephrology and Dialysis, Sestre Milosrdnice University Hospital, Zagreb, Croatia.
Pecanić
Z
Z
Getaldić
B
B
D058186:Acute Kidney Injury / Q000209:etiology / Q000628:therapy*; D000328:Adult; D000368:Aged; D003131:Combined Modality Therapy; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000150:complications*; D010956:Plasmapheresis; D006435:Renal Dialysis