[Bromocryptin + gonadotropin vs. goserelin + gonadotropin in ovulation induction in patients with polycystic ovaries].
OBJECTIVE
To evaluate the efficacy and tolerability of treatment with goserelin + HMG vs bromocriptine + FSH + HMG in the induction of ovulation in patients with ovarian polycystosis.


METHODS
A randomized prospective study.


METHODS
Sterile women with ovarian polycystosis of the first type not responding to clomiphene citrate.


METHODS
Group A: bomocriptine + FSH + HMG (10 patients); Group B: goserelin depot (Zoladex) + HMG (18 patients).


RESULTS
A greater percentage of ovulations, pregnancies and a higher success rate were obtained in Group B. The percentage of hyperstimulation was similar in both groups; there was a higher percentage of abortion in Group A. Cycle duration and the number of phials of gonadotropin were greater in Group B.


CONCLUSIONS
Treatment with bromocriptine + gonadotropin remains the simplest; the treatment protocol based on geserelin depot + gonadotropin proved to be more efficacious.
De Vita
V
V
Divisione di Ostetricia e Ginecologia, Ospedale di Massafra, Taranto.
D000328:Adult; D001971:Bromocriptine / Q000008:administration & dosage*; D002985:Clinical Protocols; D004305:Dose-Response Relationship, Drug; D005260:Female; D005640:Follicle Stimulating Hormone / Q000008:administration & dosage*; D017273:Goserelin / Q000008:administration & dosage*; D006801:Humans; D007247:Infertility, Female / Q000188:drug therapy / Q000209:etiology; D008596:Menotropins / Q000008:administration & dosage*; D010062:Ovulation Induction / Q000379:methods*; D011085:Polycystic Ovary Syndrome / Q000150:complications*; D011247:Pregnancy; D011248:Pregnancy Complications; D011256:Pregnancy Outcome
D017273:Goserelin; D001971:Bromocriptine; D008596:Menotropins; D005640:Follicle Stimulating Hormone
Bromocriptina + gonadotropine vs goserelin + gonadotropine nell'induzione dell'ovulazione in pazienti con policistosi ovarica.