Ocular adverse effects of neuropsychiatric agents. Incidence and management.
Neuropsychiatric agents may adversely affect the eye in various ways. The more frequently encountered effects include corneal oedema and pigmentary changes in the lens and cornea which are induced by phenothiazine derivatives; thioridazine-induced retinopathy; tricyclic antidepressant-induced accommodation interference and glaucoma; and lithium carbonate-induced exophthalmos and papilloedema. Several adverse effects, such as corneal oedema, retinopathy and glaucoma, are vision-threatening, and patients often fail to describe their symptoms properly. A more precise understanding of these conditions is essential for prompt diagnosis and appropriate treatment.
Oshika
T
T
Division of Ophthalmology, Tokyo University Branch Hospital, Japan.
D000065:Accommodation, Ocular / Q000187:drug effects; D014150:Antipsychotic Agents / Q000008:administration & dosage / Q000009:adverse effects*; D003315:Cornea / Q000187:drug effects; D003316:Corneal Diseases / Q000139:chemically induced; D005123:Eye / Q000187:drug effects*; D005128:Eye Diseases / Q000139:chemically induced*; D005901:Glaucoma / Q000139:chemically induced; D006801:Humans; D007908:Lens, Crystalline / Q000187:drug effects; D012174:Retinitis Pigmentosa / Q000139:chemically induced
D014150:Antipsychotic Agents