Development of plaque and gingivitis after mouthrinsing with 0.2% delmopinol hydrochloride.
A double-blind, randomized, 2-wk experimental gingivitis clinical trial with cross-over design in 14 dental students was conducted in order to study the efficacy and safety of delmopinol hydrochloride solution (2 mg/ml), used with no other oral hygiene procedures, in comparison with placebo. Plaque formation was measured by the Quigley & Hein Plaque Index and gingivitis was assessed by bleeding on probing according to Mühlemann & Son. Rinsing with delmopinol resulted in lower plaque scores compared to placebo. The development of gingivitis was weak during the 2-wk test periods, and thus no conclusive results were obtained. As in previous studies, the most frequent adverse event when rinsing with delmopinol was a transient anaesthetic sensation in the oral mucosa. The results showed that rinsing with delmopinol hydrochloride solution (2 mg/ml) for 60 s twice daily with no other oral hygiene procedures led to less plaque formation than rinsing with placebo. This study also showed good tolerance and acceptability of mouthrinsing with delmopinol.
Hase
J C
JC
Clinical Research Department, Biosurface AB, Malmö, Sweden.
Söder
P O
PO
Söder
B
B
Kulstad
S
S
Kelty
E
E
D000328:Adult; D018592:Cross-Over Studies; D003773:Dental Plaque / Q000517:prevention & control*; D003774:Dental Plaque Index; D004311:Double-Blind Method; D005891:Gingivitis / Q000517:prevention & control*; D006801:Humans; D008297:Male; D009025:Morpholines / Q000627:therapeutic use*; D009067:Mouthwashes / Q000627:therapeutic use*; D010512:Periodontal Index; D018709:Statistics, Nonparametric; D016896:Treatment Outcome
D009025:Morpholines; D009067:Mouthwashes; C073738:delmopinol