Asymptomatic visceral leishmaniasis in a child with acute lymphoblastic leukaemia.
Visceral leishmaniasis was detected incidentally in a patient with acute lymphoblastic leukaemia in remission, during maintenance therapy. Absence of fever, a normal haemogram, normal serum globulins, a negative serology and testicular involvement were the hallmarks of the case. Treatment with sodium stibogluconate (20 mg/kg for 55 days) failed. Subsequent therapy with pentamidine resulted in complete parasite clearance. Prolonged therapy with pentavalent antimony compounds or a higher dose of second line drugs such as pentamidine are recommended for complete clearance.
Mehrotra
R
R
Department of Hematology, All India Institute of Medical Sciences, New Delhi.
Choudhry
V P
VP
Saxena
R
R
Kapila
K
K
Saraya
A K
AK
D000967:Antimony Sodium Gluconate / Q000627:therapeutic use; D002675:Child, Preschool; D006801:Humans; D007194:India; D007898:Leishmaniasis, Visceral / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D008297:Male; D010419:Pentamidine / Q000627:therapeutic use; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000150:complications*; D012074:Remission Induction; D013733:Testicular Diseases / Q000150:complications* / Q000188:drug therapy; D013997:Time Factors
D010419:Pentamidine; D000967:Antimony Sodium Gluconate