title: A follow-up study of pulmonary function tests, bronchoalveolar lavage cells, and humoral and cellular immunity in bird fancier's lung.
abstract: OBJECTIVE
  The long-term outcome of bird fancier's lung appears to be variable. The objective of this study is to clarify the sequelae of disease process in bird fancier's lung, with special reference to the humoral and cellular immune responses after avoidance of direct antigen exposure.
  
  
  METHODS
  Five patients with bird fancier's lung were studied for various parameters including pulmonary function tests, cellular profiles of bronchoalveolar lavage (BAL) fluids, determinations of antibodies in BAL fluids and sera, and antigen-induced proliferation of peripheral and bronchoalveolar lymphocytes during the 5 years of follow-up.
  
  
  RESULTS
  Four of five patients showed improvement in pulmonary function, and one showed marked deterioration. This patient's room was close to the pigeon coop where her son was breeding pigeons, resulting in low-grade antigenic stimulation. Three patients demonstrated an increase in CD8+ cells in BAL fluid, but the remaining two showed an increase in CD4+ cells. The levels of IgA antibodies remained unchanged, whereas IgG levels started declining after the first 3 years of follow-up. Antigen-induced proliferation of BAL lymphocytes from all five patients and blood lymphocytes from four of five patients became weaker and gradually approached normal levels. One patient had pulmonary fibrosis and showed significant reduction in pulmonary functions but elevated reactivity of BAL lymphocytes to pigeon antigens.
  
  
  CONCLUSIONS
  This follow-up study demonstrates persistence of sensitized lymphocytes and antibody production in the respiratory tract and warrants careful evaluation of patients with bird fancier's lung, even after antigen avoidance.
authors.affiliation: First Department of Internal Medicine, Tokyo Medical and Dental University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshizawa
authors.forename: S
authors.initials: S
authors.lastname: Miyake
authors.forename: Y
authors.initials: Y
authors.lastname: Sumi
authors.forename: K
authors.initials: K
authors.lastname: Hisauchi
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: V P
authors.initials: VP
authors.lastname: Kurup
mesh_terms: D000328:Adult; D000818:Animals; D000906:Antibodies / Q000032:analysis; D000917:Antibody Formation; D000941:Antigens / Q000276:immunology; D001716:Bird Fancier's Lung / Q000276:immunology* / Q000503:physiopathology*; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology*; D010856:Columbidae; D005243:Feces; D005500:Follow-Up Studies; D006801:Humans; D007111:Immunity, Cellular; D016130:Immunophenotyping; D008168:Lung / Q000503:physiopathology*; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000502:physiology; D008875:Middle Aged; D010311:Parrots; D012129:Respiratory Function Tests
chemical_list: D000906:Antibodies; D000941:Antigens