title: Interstitial brachytherapy versus cytoreductive surgery in recurrent malignant glioma.
abstract: In selected patients with recurrent malignant glioma, interstitial brachytherapy has been advocated as an effective method for tumor control and prolonged survival. We are presenting our results with brachytherapy in patients with recurrent glioma, and comparing this technique with cytoreductive surgery. Twenty patients (9 male, 11 female) underwent stereotactic 125I implantation for recurrent malignant glioma (9 grade III, 11 grade IV). The average age was 43 years and the average Karnofsky score was 76. All patients had received radiation therapy following their initial surgical procedure and 17 received chemotherapy. The median interval from initial procedure to implantation was 70.5 weeks. The median survival following implantation was 24 weeks and total median survival for the group was 94.5 weeks. This group was compared to a contemporary series of 22 patients (16 male, 6 female) who underwent cytoreductive surgery for malignant glioma (10 grade III, 12 grade IV). The average age was 44 years and the average Karnofsky score was 76. All patients received radiation therapy following their initial procedure and 20 patients also received chemotherapy. The median interval from initial procedure to second procedure was 35.5 weeks, and from the second procedure to death was 28 weeks. The median survival for the group was 63.5 weeks. The interval from the first procedure to the second procedure was statistically significant comparing the implant group (median 70.5 weeks) versus the cytoreductive surgery group (median 35.5 weeks; p = 0.04). No significant difference could be demonstrated between the interval from second procedure to death in the implant group (median 24 weeks) versus cytoreductive surgery group (median 28 weeks; p = 0.45).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Neurosurgery, University of Iowa, Iowa City, USA.
authors.forename: T C
authors.initials: TC
authors.lastname: Ryken
authors.forename: P W
authors.initials: PW
authors.lastname: Hitchon
authors.forename: J C
authors.initials: JC
authors.lastname: VanGilder
authors.forename: B C
authors.initials: BC
authors.lastname: Wen
authors.forename: S
authors.initials: S
authors.lastname: Jani
mesh_terms: D000328:Adult; D001918:Brachytherapy / Q000379:methods*; D001932:Brain Neoplasms / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D005260:Female; D005910:Glioma / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D006801:Humans; D007457:Iodine Radioisotopes / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D009364:Neoplasm Recurrence, Local / Q000401:mortality / Q000473:pathology / Q000628:therapy*; D009493:Neurosurgery / Q000379:methods*; D015996:Survival Rate
chemical_list: D007457:Iodine Radioisotopes