title: [The effect of retinoic acid on DNA synthesis of fibroblast in vitro culture].
abstract: The effect of retinoic acid on DNA synthesis of fibroblast was studied in vitro culture. The results demonstrated that retinoic acid significantly (P < 0.01) inhibited the DNA synthesis of fibroblast in vitro culture and a dose-dependent relationship between DNA synthesis and retinoic acid concentration was observed. The possible mechanism of retinoic acid used for the treatment of scar was discussed.
authors.affiliation: Plastic Surgery Hospital, Chinese Academy of Medical Sciences, Beijing.
authors.forename: W
authors.initials: W
authors.lastname: Song
authors.forename: Z
authors.initials: Z
authors.lastname: Guan
authors.forename: G
authors.initials: G
authors.lastname: Sun
mesh_terms: D002478:Cells, Cultured; D004247:DNA / Q000096:biosynthesis* / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005347:Fibroblasts / Q000378:metabolism; D006801:Humans; D014212:Tretinoin / Q000494:pharmacology*
chemical_list: D014212:Tretinoin; D004247:DNA