Analysis of beta-thalassemia mutations in the United Arab Emirates provides evidence for recurrent origin of the IVSI nt 5 (G-C) mutation.
Beta-thalassemia mutations were characterized in a sample of 70 patients from United Arab Emirates (U.A.E.), resulting in an enlargement of the spectrum of types found in the country. The complete association between the most common IVS I nt 5 (G-C) mutation and a specific haplotype reveals an independent origin of this mutation in U.A.E.
De Leo
R
R
Institute of Cell Biology, C.N.R., Rome, Italy.
Deidda
G
G
Novelletto
A
A
el-Kalla
S
S
Mathews
A R
AR
Felicetti
L
L
D004252:DNA Mutational Analysis; D006239:Haplotypes; D006801:Humans; D009154:Mutation; D012008:Recurrence; D014479:United Arab Emirates; D017086:beta-Thalassemia / Q000235:genetics*