Comparative antibacterial activity of L-695,256, a carbapenem active against methicillin-resistant staphylococci.
The activity of a new prototype carbapenem, L-695,256, against clinical isolates of gram-positive and gram-negative aerobes was studied in vitro by agar dilution. L-695,256 was highly active against methicillin-resistant and -susceptible isolates of staphylococci (MICs, 0.016 to 2 micrograms/ml) and against penicillin-resistant pneumococci (MICs, 0.016 to 0.064 micrograms/ml), irrespective of penicillin susceptibility. Activity against members of the family Enterobacteriaceae was less than that of imipenem, while Proteus mirabilis and Morganella morganii were more susceptible to L-695,256.
Rylander
M
M
Department of Clinical Microbiology, Karolinska Institute, Karolinska Hospital, Stockholm, Sweden.
Rollof
J
J
Jacobsson
K
K
Norrby
S R
SR
D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D001419:Bacteria / Q000187:drug effects; D015780:Carbapenems / Q000494:pharmacology; D004755:Enterobacteriaceae / Q000187:drug effects; D006801:Humans; D007093:Imidazoles / Q000494:pharmacology; D016106:Methicillin Resistance / Q000502:physiology*; D008826:Microbial Sensitivity Tests; D013203:Staphylococcal Infections / Q000382:microbiology; D013211:Staphylococcus aureus / Q000187:drug effects*; D013296:Streptococcus pneumoniae / Q000187:drug effects
D000900:Anti-Bacterial Agents; D015780:Carbapenems; D007093:Imidazoles; C093180:L 695256