Inhibitors of lipid peroxidation protect cultured neurons against cyanide-induced injury.
We tested the 21-aminosteroid U-74500A and the 2-methylaminochroman U-83836E, two potent inhibitors of lipid peroxidation, for their protective efficacy against cyanide- or Fe2+/Fe(3+)-induced damage of cultured neurons from chick embryo telencephalon. U-74500A (0.1-10 microM) as well as U-83836E (0.01-10 microM) reduced cyanide-induced neurotoxicity, indicating that lipid peroxidation plays an important role in the genesis of cyanide-induced neuronal injury. Both U-74500A and U-83836E, but not the NMDA antagonist dizocilpine (1 microM, prevented Fe2+/Fe(3+)-induced neuronal degeneration.
Müller
U
U
Institut für Pharmakologie und Toxikologie, Fachbereich Pharmazie und Lebensmittelchemie, Philipps-Universität, Marburg, Germany.
Krieglstein
J
J
D000818:Animals; D002478:Cells, Cultured; D002642:Chick Embryo; D002839:Chromans / Q000494:pharmacology; D003486:Cyanides / Q000494:pharmacology; D016291:Dizocilpine Maleate / Q000494:pharmacology; D007501:Iron / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008054:Lipid Peroxides / Q000037:antagonists & inhibitors*; D009474:Neurons / Q000187:drug effects*; D010879:Piperazines / Q000494:pharmacology; D011281:Pregnatrienes / Q000494:pharmacology; D013687:Telencephalon / Q000187:drug effects / Q000196:embryology* / Q000378:metabolism
D002839:Chromans; D003486:Cyanides; D008054:Lipid Peroxides; D010879:Piperazines; D011281:Pregnatrienes; C066382:U 78517F; D016291:Dizocilpine Maleate; D007501:Iron; C053356:U 74500A