title: Pentoxifylline pretreatment fails to block the acute-phase response to Escherichia coli endotoxin in dwarf goats.
abstract: The purpose of this study was to assess whether pentoxifylline, a drug that can inhibit the production and action of pro-inflammatory cytokines, had beneficial effects on the acute-phase response to E. coli endotoxin in the dwarf goat. First, the effects of 0.5 mg/kg per min pentoxifylline given intravenously over 15 min were examined in five goats. One week later, the clinical changes caused by i.v. injection of E. coli endotoxin (LPS: 0.1 microgram/kg) were determined. This endotoxin induced fever, tachycardia, inhibition of rumen motility, and decreases in plasma zinc and iron concentrations. Three weeks later, the effect of E. coli LPS were again determined immediately after pentoxifylline infusion in the same group of animals. It was concluded that a pharmacological dose of pentoxifylline has no protective effects on the acute-phase response reactions induced by a pyrogenic dose of E. coli LPS.
authors.affiliation: Department of Veterinary Basic Sciences, Faculty of Veterinary Medicine, Utrecht University, The Netherlands.
authors.forename: C T
authors.initials: CT
authors.lastname: Van Duin
authors.forename: T
authors.initials: T
authors.lastname: Wensing
authors.forename: A S
authors.initials: AS
authors.lastname: Van Miert
mesh_terms: D000210:Acute-Phase Reaction / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control / Q000662:veterinary*; D000818:Animals; D001831:Body Temperature / Q000187:drug effects; D004731:Endotoxins / Q000633:toxicity*; D004926:Escherichia coli; D005260:Female; D005334:Fever / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary; D005769:Gastrointestinal Motility / Q000187:drug effects; D015511:Goat Diseases / Q000097:blood / Q000139:chemically induced / Q000517:prevention & control*; D006041:Goats; D006339:Heart Rate / Q000187:drug effects; D007262:Infusions, Intravenous / Q000662:veterinary; D007501:Iron / Q000097:blood; D008297:Male; D010431:Pentoxifylline / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D013610:Tachycardia / Q000139:chemically induced / Q000188:drug therapy / Q000662:veterinary; D015032:Zinc / Q000097:blood
chemical_list: D004731:Endotoxins; D007501:Iron; D015032:Zinc; D010431:Pentoxifylline