The influence of brain acetaldehyde on oxidative status, dopamine metabolism and visual discrimination task.
The toxic effect of acetaldehyde on brain oxidative capacity and dopamine metabolism has been investigated in rat brains after a single intraperitoneal injection of acetaldehyde (5 mmol/kg) and the results compared with those from chronically ethanol fed rats. Acetaldehyde was present in rat brain 120 hr after a single dose of acetaldehyde, confirming that it is able to cross the blood-brain barrier. Brain catalase increased significantly after acetaldehyde or chronic ethanol administration although there were no other significant changes in the total brain activity of superoxide dismutase, glutathione peroxidase or glutathione reductase. Dopamine turnover was increased in both experimental groups. The acute dose of acetaldehyde reduced the ability of the rats to relearn a computer visual discrimination task.
Heap
L
L
Department of Clinical Biochemistry, Kings College School of Medicine and Dentistry, London, U.K.
Ward
R J
RJ
Abiaka
C
C
Dexter
D
D
Lawlor
M
M
Pratt
O
O
Thomson
A
A
Shaw
K
K
Peters
T J
TJ
D000079:Acetaldehyde / Q000097:blood / Q000378:metabolism / Q000633:toxicity*; D000818:Animals; D001812:Blood-Brain Barrier; D001923:Brain Chemistry; D002374:Catalase / Q000378:metabolism; D004298:Dopamine / Q000378:metabolism*; D000431:Ethanol / Q000378:metabolism / Q000633:toxicity; D005978:Glutathione / Q000378:metabolism; D005979:Glutathione Peroxidase / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D010084:Oxidation-Reduction; D018384:Oxidative Stress; D051381:Rats; D017208:Rats, Wistar; D014796:Visual Perception
D000431:Ethanol; D002374:Catalase; D005979:Glutathione Peroxidase; D005978:Glutathione; D000079:Acetaldehyde; D004298:Dopamine