title: Neuronal regeneration and estrous cycle restoration after locus coeruleus-periventricular gray substance section.
abstract: The locus coeruleus (LC) was anatomically separated from the periventricular gray substance (PVG) by means of knife cuts in the adult female rat presenting regular estrous cycling. This resulted in a transient suppression of the estrous cycling that lasted 10-13 days after surgery. After this period, irregular or regular cycling activity was observed. The regular cycling was restored 30-45 days after the knife cuts. Golgi impregnation of some of the brains of these rats revealed regenerative elements in the knife-cut-insulted area. Thus, blood vessels, macrophagic-like elements, and glial-like elements were observed in close relation with the knife-cut pathway. Additionally, well-defined stained neurons typical of the LC and PVG were observed in close proximity to the knife-cut pathway. Dendritic and axon projections towards the insulted area were observed. Well defined axons were seen across the knife-cut pathway. These data support, first, that the LC-PVG communication is part of a circuitry for the modulation of gonadotropic activity, and second, that in the restoration of the estrous cyclicity after the knife cut, regenerative processes leading to a LC-PVG functional reconnection occurred after the knife cut.
authors.affiliation: Departamento de Fisiología, Facultad de Medicina, Universidad Nacional Autónoma de México, México, D.F.
authors.forename: L P
authors.initials: LP
authors.lastname: Solano-Flores
authors.forename: M P
authors.initials: MP
authors.lastname: Rosas-Arellano
authors.forename: R
authors.initials: R
authors.lastname: Guevara-Guzmán
authors.forename: L
authors.initials: L
authors.lastname: Cintra-McGlone
authors.forename: S
authors.initials: S
authors.lastname: Díaz-Cintra
mesh_terms: D000818:Animals; D004971:Estrus / Q000502:physiology*; D005260:Female; D007031:Hypothalamus / Q000033:anatomy & histology / Q000502:physiology*; D008125:Locus Coeruleus / Q000033:anatomy & histology / Q000502:physiology*; D009416:Nerve Regeneration / Q000502:physiology*; D009434:Neural Pathways / Q000033:anatomy & histology / Q000502:physiology; D009474:Neurons / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar