title: [CD4+ lymphocytes and opportunistic infections and neoplasms in patients with human immunodeficiency virus infection].
abstract: BACKGROUND
  The CD4+ lymphocytes are the principal target cell for the human immunodeficiency virus (HIV). Their depletion originates a very severe cell immunosuppression, which conditions the appearance of opportunistic infections and neoplasms characteristic of AIDS. The aim of this study was to evaluate whether there is a relation between the degree of cell immunosuppression and the type of opportunistic infections and neoplasms which these patients develop in Spain.
  
  
  METHODS
  The CD4+ lymphocyte counts in 400 adults with HIV infection who developed opportunistic infections or neoplasms were retrospectively reviewed (1987-1991). This determination was carried out during between two months prior to diagnosis of AIDS (CDC, 1987) to one month after such diagnosis.
  
  
  RESULTS
  The results allowed opportunistic infections to be classified into three groups according to the grade of immunosuppression: 1) opportunistic infections with more than 0.2 x 10(9) CD4+ lymphocytes/l (45-60% of cases of tuberculosis, esophageal candidiasis and enteritis by Isospora belli); 2) opportunistic infections with 0-0.2 x 10(9) CD4/l (87-100% of the cases of pneumonia by Pneumocystis carinii, encephalic toxoplasmosis, visceral leishmaniasis and enteritis by Cryptosporidium); 3) opportunistic infections with 0-0.1 x 10(9) CD4 lymphocytes/l (70-100% of the cases of systemic cryptococcosis, retinitis by cytomegalovirus, progressive multifocal leukoencephalopathy and infection by Mycobacterium avium-intracellulare). With respect to the neoplasms, Kaposi's sarcoma was observed in patients with different degrees of immunosuppression. Seventy-five and 80% of the patients with non Hodgkin's lymphoma and primary cerebral lymphoma had less than 0.2 x 10(9)/l and less than 0.1 x 10(9)/l CD4+ lymphocytes, respectively.
  
  
  CONCLUSIONS
  The CD4 lymphocyte counts may predict the type of opportunistic infections which patients with the human immunodeficiency virus infection may develop.
authors.affiliation: Servicio de Enfermedades Infecciosas, Hospital Clínic i Provincial, Universidad de Barcelona.
authors.forename: J M
authors.initials: JM
authors.lastname: Miró
authors.forename: E
authors.initials: E
authors.lastname: Buira
authors.forename: J
authors.initials: J
authors.lastname: Mallolas
authors.forename: T
authors.initials: T
authors.lastname: Gallart
authors.forename: A
authors.initials: A
authors.lastname: Moreno
authors.forename: L
authors.initials: L
authors.lastname: Zamora
authors.forename: R
authors.initials: R
authors.lastname: Vilella
authors.forename: J M
authors.initials: JM
authors.lastname: Gatell
authors.forename: E
authors.initials: E
authors.lastname: Soriano
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology*; D015496:CD4-Positive T-Lymphocytes; D002452:Cell Count; D015658:HIV Infections / Q000150:complications / Q000276:immunology*; D006801:Humans; D016483:Lymphoma, AIDS-Related / Q000276:immunology*; D012189:Retrospective Studies; D012514:Sarcoma, Kaposi / Q000209:etiology / Q000276:immunology*
vernacular_title: Linfocitos CD4+ e infecciones oportunistas y neoplasias en pacientes con infección por el virus de la inmunodeficiencia humana.