title: Influence of metabolic control on the ventilatory threshold in adults with non insulin-dependent diabetes mellitus.
abstract: Metabolic control, as assessed by glycosylated hemoglobin (HbA1c), has been reported to have a relationship to various submaximal exercise responses. However, due to the narrow range of HbA1c and the limited exercise data from previous studies on individuals with diabetes, little support for the above statement exists in the literature. The current study assessed the relationship between HbA1c and submaximal, or ventilatory threshold (VT), and maximal exercise (VO2 peak) responses in subjects with non-insulin-dependent diabetes mellitus (NIDDM). Sixteen subjects (age = 56.5 +/- 14.4 yrs; Wt = 82.6 +/- 17.2 kg; B.M.I. = 29.5 +/- 2.7 kg.m-2) performed a ramp (20 watts.min-1) leg cycle ergometer test (GXT). Their HbA1c was 11.8 +/- 2.8% (range 6.5 to 16.6%). Breath by breath respiratory analysis was performed using a Med Graphics 2001 cart. Ventilatory threshold (VT) was determined using the V-slope method. The VT was 1,151 +/- 487 ml.min-1 or 70.2 +/- 10% VO2peak; VO2peak was 1,645 +/- 740 ml.min-1. There were no significant relationships found between HbA1c and the VO2 at the VT (r = 0.04), the % of VO2peak at the VT (r = 0.23), and the VO2peak (r = 0.17). In conclusion, metabolic control, as assessed by HbA1c, did not influence selected submaximal and maximal exercise responses in NIDDM. Therefore, exercise prescription for individuals with NIDDM may not need to consider the individual's HbA1c concentration as a modifier of their exercise response.
authors.affiliation: School of Physical Education, Ball State University, Muncie, IN 47306, USA.
authors.forename: G B
authors.initials: GB
authors.lastname: Dwyer
authors.forename: J P
authors.initials: JP
authors.lastname: Wallace
authors.forename: M H
authors.initials: MH
authors.lastname: Whaley
mesh_terms: D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D003924:Diabetes Mellitus, Type 2 / Q000378:metabolism / Q000503:physiopathology*; D005080:Exercise Test; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis*; D006339:Heart Rate; D006801:Humans; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D005082:Physical Exertion; D012119:Respiration
chemical_list: D015415:Biomarkers; D006442:Glycated Hemoglobin