[Effect of the preparation "Loshtak" on the clastogenic activity cyclophosphamide].
The anticlastogenic effect of the herbal preparation Loshtak on rats and mice was tested using the same scheme of treatment and doses of the preparation as are employed in medical practice. It was shown that intragastric administration of Loshtak results in a statistically significant decrease in the clastogenic effect of cyclophosphamide injected 48 h after the end of treatment with Loshtak. High doses of Loshtak did not induce any increase in the number of micronuclei in mouse bone marrow cells. Possible mechanisms responsible for the anticlastogenic effect of Loshtak are discussed.
Mkrtchian
L N
LN
Nersesian
A K
AK
Panosian
A G
AG
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D003520:Cyclophosphamide / Q000633:toxicity*; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D009153:Mutagens / Q000633:toxicity*; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal / Q000737:chemistry*; D051381:Rats; D017208:Rats, Wistar
D016587:Antimutagenic Agents; D009153:Mutagens; D010936:Plant Extracts; D003520:Cyclophosphamide
Deĭstvie preparata "loshtak" na kalstogennuiu aktivnost' tsiklofosfana.