The genotype of the angiotensin-converting enzyme gene and global left ventricular dysfunction after myocardial infarction.
We examined the relation between the genotype of the angiotensin-converting enzyme (ACE) gene and the development of left ventricular dysfunction, as assessed by biplane left ventriculograms, after myocardial infarction. Seventy-nine patients (deletion homozygote [DD] = 13; insertion/deletion heterozygote [ID] = 38; insertion homozygote [II] = 28) underwent cardiac catheterization twice for reevaluation of percutaneous transluminal coronary angioplasty. Subjects who had their first cardiac catheterization within 2 months from the onset of myocardial infarction were enrolled. The second cardiac catheterization was performed from 4 to 7 months after the first cardiac catheterization. ACE genotypes were determined by using the polymerase chain reaction. Ejection fraction, and end-diastolic and end-systolic volume indexes at the first cardiac catheterization were not significantly different among the 3 groups. The end-diastolic volume index at the second cardiac catheterization was not significantly different among the 3 groups. Ejection fractions (mean +/- SD) at the second catheterization in the 3 groups were 0.51 +/- 0.15 (DD), 0.56 +/- 0.12 (ID), and 0.62 +/- 0.09 (II) (p = 0.02), and were significantly lower in the DD group than in the II group. The end-systolic volume indexes (mean +/- SD) were 46 +/- 21 (DD), 43 +/- 24 (ID), and 30 +/- 14 (II) ml/m2 (p = 0.01), and were significantly greater in the DD and ID groups than in the II group.(ABSTRACT TRUNCATED AT 250 WORDS)
Ohmichi
N
N
First Department of Internal Medicine, Shiga University of Medical Sciences, Japan.
Iwai
N
N
Nakamura
Y
Y
Kinoshita
M
M
D000368:Aged; D000704:Analysis of Variance; D015906:Angioplasty, Balloon, Coronary; D006328:Cardiac Catheterization; D004247:DNA / Q000032:analysis; D005260:Female; D005500:Follow-Up Studies; D017353:Gene Deletion; D006579:Heterozygote; D006720:Homozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009203:Myocardial Infarction / Q000150:complications / Q000235:genetics* / Q000628:therapy; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D016133:Polymerase Chain Reaction; D013318:Stroke Volume; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000209:etiology / Q000235:genetics*
D004247:DNA; D007703:Peptidyl-Dipeptidase A