The role of plasma, erythrocyte and platelet myo-inositol levels in the development of diabetic microangiopathy.
In this study the plasma, erythrocyte, and platelet myo-inositol levels in 24 type I, 24 type II diabetics, and in 15 healthy controls were determined. The diabetics were devided into two groups with microangiopathy (n = 26) and without microangiopathy (n = 22). The plasma, erythrocyte, and platelet myo-inositol levels in the whole diabetic group and control subjects were as follows. Diabetic group: 46.5 +/- 39.8 mumol.l-1 23.3 +/- 19.8 nmol.ml-1, 2.6 +/- 2.8 nmol.ml-1 (10(5) cells)-1.


METHODS
17.4 +/- 3.7 mumol.l-1, 12.2 +/- 5.2 nmol.ml-1, 1.5 +/- 0.9 nmol.ml-1 (10(5) cells)-1. The values of the diabetic group were significantly higher than the values of the control group (p < 0.01). In patients with HbA1c levels more than 9% plasma, erythrocyte, and platelet myo-inositol values were significantly higher than the values of the group with HbA1C levels less than 9% (p < 0.05, p < 0.05 and p < 0.01). In diabetics without complications plasma and erythrocyte myo-inositol levels were higher than the values of the control group (p < 0.01), whereas there was no significant difference between the platelet myo-inositol values. In diabetics with complication all these three values were higher than those of the control group (p < 0.01, p < 0.01, p < 0.01). The most profound increase in the plasma, erythrocyte, and platelet myo-inositol levels were seen in complicated diabetics with a diabetes duration of 6-10 years (p < 0.01). After 10 years duration the values declined. In the group without complication there was no difference according to the duration of diabetes.
Hacibekiroğlu
M
M
Department of Biochemistry, Cerrahpasa Faculty of Medicine, University of Istanbul, Turkey.
Akçay
T
T
D000328:Adult; D001792:Blood Platelets / Q000378:metabolism*; D003404:Creatinine / Q000097:blood; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood*; D004912:Erythrocytes / Q000378:metabolism*; D005260:Female; D006442:Glycated Hemoglobin / Q000032:analysis; D006801:Humans; D007294:Inositol / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010949:Plasma; D012016:Reference Values; D013997:Time Factors
D003404:Creatinine; D006442:Glycated Hemoglobin; D007294:Inositol