Pulmonary hypertension and dexfenfluramine.
Appetite suppressants, including aminorex and fenfluramine, have been associated with pulmonary hypertension ever since the well-known outbreak of primary pulmonary hypertension in Europe after treatment with aminorex. The usage of a new anorectic agent, dexfenfluramine, has recently increased dramatically in developed countries. We report 2 new cases of lethal pulmonary hypertension associated with the use of dexfenfluramine.
Cacoub
P
P
Dorent
R
R
Nataf
P
P
Houppe
J P
JP
Piette
J C
JC
Godeau
P
P
Gandjbakhch
I
I
D005260:Female; D005277:Fenfluramine / Q000009:adverse effects*; D006801:Humans; D006976:Hypertension, Pulmonary / Q000139:chemically induced* / Q000503:physiopathology; D008875:Middle Aged
D005277:Fenfluramine