Pulmonary hemosiderosis and immune complex glomerulonephritis.
Two children with a syndrome of pulmonary hemorrhage and immune complex nephritis are reported. Clinical history suggests that pulmonary lesions precede renal abnormalities. Necrotizing glomerulonephritis with granular immune deposits along the glomerular basement membrane was found. Although the etiology of this disease complex is still unknown, the clinical and pathological findings in these patients suggest that immune complex glomerulonephritis is an unusual complication of idiopathic pulmonary hemosiderosis.
van der Ent
C K
CK
Wilhelmina Children's Hospital, University Hospital for Children and Youth, Utrecht, The Netherlands.
Walenkamp
M J
MJ
Donckerwolcke
R A
RA
van der Laag
J
J
van Diemen-Steenvoorde
R
R
D019867:Anti-Glomerular Basement Membrane Disease / Q000209:etiology* / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D005260:Female; D006486:Hemosiderosis / Q000150:complications* / Q000276:immunology; D006801:Humans; D007105:Immune Complex Diseases / Q000209:etiology* / Q000276:immunology; D007678:Kidney Glomerulus / Q000276:immunology / Q000473:pathology; D008171:Lung Diseases / Q000150:complications* / Q000276:immunology