Gene regulatory proteins and their interaction with DNA.
The selective expression of a gene is achieved through the interaction of protein transcription factors with characteristic DNA sequences located in the regulatory region of the gene, which is usually distinct from the coding region. These proteins contain domains that bind specifically to the DNA sites (or response elements). Some general principles in the design of these DNA-binding domains are described, followed by examples of the different structural classes discovered so far and how they recognize their binding sites.
Klug
A
A
MRC Laboratory of Molecular Biology, Cambridge, England.
D000818:Animals; D004247:DNA / Q000378:metabolism*; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism*; D005786:Gene Expression Regulation; D005801:Genes, Homeobox; D018257:Helix-Loop-Helix Motifs; D006801:Humans; D016350:Leucine Zippers; D017433:Protein Structure, Secondary; D011956:Receptors, Cell Surface / Q000737:chemistry / Q000378:metabolism; D035181:TATA-Box Binding Protein; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D016335:Zinc Fingers
D004268:DNA-Binding Proteins; D011956:Receptors, Cell Surface; D035181:TATA-Box Binding Protein; D014157:Transcription Factors; D004247:DNA