Preclinical and clinical experience with cisplatin resistance.
Despite the general lack of clinical evidence supporting the preclinical data, there have been many attempts to overcome cisplatin resistance in clinical situations. These efforts have focused on both the proposed mechanisms of resistance as well as novel approaches to renew efficacy. In this article, the authors summarize the available clinical studies that have intentionally or serendipitously uncovered modulators of cisplatin sensitivity.
Marshall
J L
JL
Lombardi Cancer Research Center, Georgetown University Medical Center, Washington, DC, USA.
Andrews
P A
PA
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001692:Biological Transport; D002945:Cisplatin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000493:pharmacokinetics* / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D003131:Combined Modality Therapy; D004260:DNA Repair / Q000187:drug effects; D004334:Drug Administration Schedule; D004351:Drug Resistance; D018432:Drug Resistance, Multiple; D004354:Drug Screening Assays, Antitumor; D005978:Glutathione / Q000037:antagonists & inhibitors / Q000378:metabolism; D006801:Humans; D007155:Immunologic Factors / Q000627:therapeutic use; D008668:Metallothionein / Q000037:antagonists & inhibitors / Q000378:metabolism; D009363:Neoplasm Proteins / Q000378:metabolism; D009369:Neoplasms / Q000188:drug therapy* / Q000378:metabolism; D009374:Neoplasms, Experimental / Q000188:drug therapy / Q000378:metabolism; D013629:Tamoxifen / Q000494:pharmacology / Q000627:therapeutic use; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D007155:Immunologic Factors; D009363:Neoplasm Proteins; D059004:Topoisomerase I Inhibitors; D059005:Topoisomerase II Inhibitors; D013629:Tamoxifen; D008668:Metallothionein; D005978:Glutathione; D002945:Cisplatin