Translocation (5;19)(q13;q13) in a multinodular thyroid goiter.
We describe the cytogenetics of a multinodular thyroid goiter where 90% of the analyzed cells showed a diploid karyotype with a balanced translocation between chromosomes 5 and 19: 46,XX,t(5;19)(q13;q13). This translocation has been previously described in cases of thyroid adenoma. Our case is the first report of this anomaly in nodular hyperplasia. We discuss its putative role in the neoplastic transformation of thyroid lesions.
Cigudosa
J C
JC
Service of Genetics, University of La Laguna, Tenerife, Spain.
Pedrosa Guerra
A
A
Otero Gómez
A
A
Carrasco Juan
J L
JL
Pérez Gómez
J A
JA
Ferrer Roca
O F
OF
García Miranda
J L
JL
D000328:Adult; D002869:Chromosome Aberrations / Q000473:pathology*; D002871:Chromosome Banding; D025063:Chromosome Disorders; D002888:Chromosomes, Human, Pair 19; D002895:Chromosomes, Human, Pair 5; D006044:Goiter, Nodular / Q000473:pathology*; D006801:Humans; D014178:Translocation, Genetic