Serum concentrations of 5-fluorouracil achieved with nocturnal constant-rate infusion in patients with disseminated cancer.
Nocturnal infusion of 5-fluorouracil (FUra) was performed in nine patients with disseminated cancer. Three gastric, three colon and three breast cancer patients were administered 300 mg/m2 FUra continuously for 10 h per day from 2100 h to 0700 h for more than 20 consecutive days. In the first three patients, who were treated by drip infusion without the use of a volumetric pump, serum FUra concentrations ranged widely, from 27 to 130 ng/ml, even though the rate of administration was re-adjusted four times during the night. The last six patients were treated using a volumetric pump, and FUra concentrations in serum ranged from 175 to 378 ng/ml, and displayed no circadian rhythm. Although the dose intensity and area under the curve of FUra in these patients were high, neither myelosuppression nor other side effects were observed.
Furuya
Y
Y
First Department of Surgery, Kobe University School of Medicine, Japan.
Yamamoto
K
K
Kohno
N
N
Yamamoto
M
M
Saitoh
Y
Y
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood* / Q000188:drug therapy; D002940:Circadian Rhythm; D003110:Colonic Neoplasms / Q000097:blood* / Q000188:drug therapy; D004334:Drug Administration Schedule; D005260:Female; D005472:Fluorouracil / Q000008:administration & dosage* / Q000009:adverse effects / Q000097:blood*; D006801:Humans; D007958:Leukocyte Count / Q000187:drug effects; D008875:Middle Aged; D013274:Stomach Neoplasms / Q000097:blood* / Q000188:drug therapy
D005472:Fluorouracil