title: Rectal irrigations for the prevention of postoperative enterocolitis in Hirschsprung's disease.
abstract: The purpose of this clinical trial was to examine the role of rectal irrigations in the prevention of postoperative enterocolitis in children with Hirschsprung's disease. Over the past 22 years 177 children had surgical treatment for Hirschsprung's disease at a single pediatric hospital. Five children have died of other causes. Of the remaining 172 patients, follow-up clinical information was obtained from 135 (78%). In 1989, all of the children undergoing surgical reconstruction for Hirschsprung's disease were placed on routine postoperative rectal irrigations with normal saline. The parents were instructed in the irrigation technique before leaving the hospital. Irrigations were started 1 to 2 weeks postoperatively and were performed two times a day for 3 months, then once a day for an additional 3 months. There were no complications from the irrigations themselves. A previous report from the authors' institution has documented five sudden deaths over the past 22 years from fulminant postoperative enterocolitis. These five children all had an unremarkable postoperative recovery, then developed a rapidly progressive diarrheal illness. All of these deaths occurred before the institution of routine postoperative irrigations. Of the 135 patients in this review, 40 had the postoperative rectal irrigations. The remaining 95 children serve as historical controls. Data analysis showed that 34 of the 95 children in the nonirrigation cohort developed postoperative enterocolitis compared with 3 of 40 in the rectal irrigation cohort; P < .001 using Fisher's exact test. In the authors' experience, routine postoperative rectal irrigations have significantly decreased the incidence and severity of enterocolitis in children after surgical correction of Hirschsprung's disease.
authors.affiliation: University of Utah, Primary Children's Medical Center, Salt Lake City 84113-1100, USA.
authors.forename: T L
authors.initials: TL
authors.lastname: Marty
authors.forename: T
authors.initials: T
authors.lastname: Seo
authors.forename: J J
authors.initials: JJ
authors.lastname: Sullivan
authors.forename: M E
authors.initials: ME
authors.lastname: Matlak
authors.forename: R E
authors.initials: RE
authors.lastname: Black
authors.forename: D G
authors.initials: DG
authors.lastname: Johnson
mesh_terms: D002648:Child; D004760:Enterocolitis / Q000209:etiology*; D006627:Hirschsprung Disease / Q000150:complications* / Q000601:surgery*; D006801:Humans; D011183:Postoperative Complications / Q000517:prevention & control*; D007507:Therapeutic Irrigation