Cyclins, CDKs and cancer.
The connections between cancer and the basic machinery of the cell cycle have taken a surprisingly long time to become apparent. However, the past 2 years has seen a dramatic increase in the number of cell cycles regulators that have been implicated as either protooncogenes or as tumour suppressor genes. In this review I will attempt to show how perturbations in the known cell cycle regulators may play a part in the process of oncogenesis.
Pines
J
J
Wellcome/CRC Institute, Cambridge, UK.
D000818:Animals; D002453:Cell Cycle / Q000502:physiology; D018844:Cyclin-Dependent Kinases / Q000378:metabolism*; D016213:Cyclins / Q000502:physiology*; D006801:Humans; D009369:Neoplasms / Q000209:etiology* / Q000378:metabolism / Q000473:pathology; D009857:Oncogenes; D011519:Proto-Oncogenes
D016213:Cyclins; D018844:Cyclin-Dependent Kinases