title: Abnormalities of cAMP-dependent endogenous phosphorylation in platelets from patients with bipolar disorder.
abstract: OBJECTIVE
  The aim of the study was to assess cAMP-dependent endogenous phosphorylation in platelets from euthymic bipolar patients.
  
  
  METHODS
  Platelets from 10 drug-free euthymic patients with bipolar disorder were compared with those from 10 age- and sex-matched healthy subjects. Basal and cAMP-stimulated protein phosphorylation was examined in each group.
  
  
  RESULTS
  Endogenous phosphorylation in both the healthy volunteers and the bipolar patients was significantly stimulated by cAMP; the major polypeptides had apparent molecular weights of 38 and 22 kDa. The cAMP-stimulated 32P incorporation differed between the bipolar patients and the comparison subjects only in the 22-kDa band.
  
  
  CONCLUSIONS
  These data suggest a possible role of cAMP-dependent protein phosphorylation in the pathophysiology of bipolar disorder.
authors.affiliation: Center for Neuropharmacology, Institute of Pharmacological Sciences, University of Milan, Italy.
authors.forename: J
authors.initials: J
authors.lastname: Perez
authors.forename: R
authors.initials: R
authors.lastname: Zanardi
authors.forename: S
authors.initials: S
authors.lastname: Mori
authors.forename: M
authors.initials: M
authors.lastname: Gasperini
authors.forename: E
authors.initials: E
authors.lastname: Smeraldi
authors.forename: G
authors.initials: G
authors.lastname: Racagni
mesh_terms: D000328:Adult; D015415:Biomarkers; D001714:Bipolar Disorder / Q000097:blood* / Q000503:physiopathology; D001792:Blood Platelets / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism*; D000242:Cyclic AMP / Q000494:pharmacology*; D017868:Cyclic AMP-Dependent Protein Kinases / Q000378:metabolism*; D006801:Humans; D008297:Male; D010761:Phosphorus Radioisotopes / Q000378:metabolism; D010766:Phosphorylation / Q000187:drug effects
chemical_list: D015415:Biomarkers; D010761:Phosphorus Radioisotopes; D000242:Cyclic AMP; D017868:Cyclic AMP-Dependent Protein Kinases