Effects of selenium deficiency on thyroid necrosis, fibrosis and proliferation: a possible role in myxoedematous cretinism.
It has been suggested that selenium deficiency is a co-factor to iodine deficiency in the pathogenesis of myxoedematous cretinism. The mechanism proposed is that the generation of hydrogen peroxide is greatly increased in iodine-deficient thyroid glands, and that selenium is involved in the control of hydrogen peroxide and its derived free radicals. This study was carried out to investigate the effect of the possibly impaired cellular defence mechanism associated with selenium deficiency on thyroid necrosis and tissue repair. For this purpose, we studied thyroid tissue from selenium- (SE-) and/or iodine-deficient (I-) rats before and after an acute toxic iodine overload. In I- thyroids, necrotic cells were numerous. Acute iodine administration increased this effect. Necrosis was associated with transient infiltration of inflammatory cells. In I-SE+ thyroids the tissue resumed its normal appearance. In I-SE- thyroid glands, the iodide toxicity was stronger, with greater necrosis and inflammatory reaction. The inflammation resolved but was replaced by fibrotic tissue. Fifteen days after the toxic overload, the connective tissue volume was twice the control value. Before iodide overload, the proportion of dividing cells was equal in I-SE+ and I-SE- thyroids. Three days after the iodide overload, this proportion was increased in I-SE+ thyroids but reduced in the I-SE- thyroids. Overall, the I-SE- thyroids had four times fewer dividing cells than the I-SE+ thyroids. In summary, selenium deficiency coupled to iodine deficiency increased necrosis, induced fibrosis and impeded compensatory epithelial cell proliferation. These results are compatible with histological and functional description of thyroid tissue from myxoedematous cretins.
Contempre
B
B
IRIBHN, Free University of Brussels, Belgium.
Dumont
J E
JE
Denef
J F
JF
Many
M C
MC
D000818:Animals; D002455:Cell Division / Q000502:physiology; D004848:Epithelium / Q000378:metabolism / Q000473:pathology; D005260:Female; D005355:Fibrosis; D005609:Free Radicals; D006042:Goiter / Q000209:etiology / Q000473:pathology; D006861:Hydrogen Peroxide / Q000378:metabolism; D006965:Hyperplasia; D007455:Iodine / Q000008:administration & dosage / Q000172:deficiency; D009230:Myxedema / Q000209:etiology* / Q000473:pathology / Q000503:physiopathology; D009336:Necrosis; D051381:Rats; D017208:Rats, Wistar; D012643:Selenium / Q000172:deficiency* / Q000502:physiology; D013961:Thyroid Gland / Q000378:metabolism / Q000473:pathology* / Q000502:physiology
D005609:Free Radicals; D007455:Iodine; D006861:Hydrogen Peroxide; D012643:Selenium