Prolonged intake of chlorambucil for ovarian cancer.
The use of alkylating agents has been reported to be a cause of secondary leukemia particularly in patients surviving for 2 years or more after treatment of ovarian carcinoma. The risk of developing leukemia is possibly related to the duration of treatment and the total dose of alkylating agents administered. We report a patient with epithelial ovarian carcinoma who received chlorambucil for 130 consecutive months with no clinical or laboratory evidence of leukemia.
Khalil
A M
AM
Department of Obstetrics and Gynecology, American University of Beirut Medical Center, Lebanon.
Khatib
R A
RA
Shamseddine
A I
AI
Sharara
N H
NH
Seoud
M A
MA
D002699:Chlorambucil / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D003536:Cystadenocarcinoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D005260:Female; D006801:Humans; D007938:Leukemia / Q000139:chemically induced; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery
D002699:Chlorambucil