Papaverine-phentolamine and prostaglandin E1 versus papaverine-phentolamine alone for intracorporeal injection therapy: a clinical double-blind study.
OBJECTIVE
A study was designed to compare intracorporeal injections of papaverine plus phentolamine (2-drug solution) and papaverine plus phentolamine and prostaglandin E1 (3-drug solution) for the treatment for impotence.


METHODS
A total of 20 impotent patients received intracorporeal injections of the 2-drug or 3-drug solution alternately during 2 sessions, and the quality and duration of erections were assessed.


RESULTS
Of the patients 73% achieved a full erection with the 3-drug solution compared to 28% with the 2-drug solution. The average duration of erections was 57 minutes and 33.6 minutes, respectively. The complication rate was similar for the 2 treatments.


CONCLUSIONS
Papaverine plus phentolamine and prostaglandin E1 is superior to papaverine plus phentolamine alone for the treatment of impotence.
Shenfeld
O
O
Chaim Sheba Medical Center, Tel Hashomer, Israel.
Hanani
J
J
Shalhav
A
A
Vardi
Y
Y
Goldwasser
B
B
D000328:Adult; D000368:Aged; D000527:Alprostadil / Q000008:administration & dosage*; D004311:Double-Blind Method; D004338:Drug Combinations; D007172:Erectile Dysfunction / Q000188:drug therapy*; D006801:Humans; D018783:Impotence, Vasculogenic / Q000188:drug therapy; D007267:Injections; D008297:Male; D008875:Middle Aged; D010208:Papaverine / Q000008:administration & dosage*; D010410:Penile Erection; D010413:Penis; D010646:Phentolamine / Q000008:administration & dosage*
D004338:Drug Combinations; D010208:Papaverine; D000527:Alprostadil; D010646:Phentolamine