title: The effect of cisplatin and transplatin on the conformation and association of F-actin.
abstract: The effects of cisplatin and transplatin on the conformation and association of F-actin were studied by ESR, turbidimetry and CD measurement. The results indicate that the major component affecting F-actin secondary conformation is derived from their effect on the tertiary or quaternary conformation and association states of F-actin. The effect of platinum is seen by the fact that binding of cisplatin causes first an increase in molecular size followed by a later decrease. The induction time for the association depended on the concentration of cisplatin. Transplatin was able to reach the target site more readily, resulting in the dissociation of F-actin even at a very low concentration.
authors.affiliation: Beijing Medical University, China.
authors.forename: H H
authors.initials: HH
authors.lastname: Zeng
authors.forename: J F
authors.initials: JF
authors.lastname: Lu
authors.forename: K
authors.initials: K
authors.lastname: Wang
mesh_terms: D000199:Actins / Q000737:chemistry*; D000818:Animals; D002945:Cisplatin / Q000494:pharmacology*; D011487:Protein Conformation / Q000187:drug effects*; D011817:Rabbits
chemical_list: D000199:Actins; C034697:transplatin; D002945:Cisplatin