title: The effects of aspirin on the CNV in healthy individuals.
abstract: The effects of aspirin on the contingent negative variation (CNV) of 16 healthy, right-handed volunteers were studied in accordance with a placebo-controlled double-blind crossover design. Early and late CNV factors were measured. Aspirin caused a statistically significant decrease of the early wave and an increase of mean amplitude of the late wave. A central action of aspirin, affecting noradrenergic and dopaminergic structures, may be responsible for the CNV changes.
authors.affiliation: Department of Neurology, Sechenov's Moscow Medical Academy, Russia.
authors.forename: A
authors.initials: A
authors.lastname: Vein
authors.forename: T
authors.initials: T
authors.lastname: Voznesenskaya
authors.forename: A
authors.initials: A
authors.lastname: Danilov
mesh_terms: D000293:Adolescent; D000328:Adult; D000704:Analysis of Variance; D001241:Aspirin / Q000494:pharmacology*; D003265:Contingent Negative Variation / Q000187:drug effects*; D018592:Cross-Over Studies; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy / Q000503:physiopathology; D012016:Reference Values
chemical_list: D001241:Aspirin