Reduction of substance P binding sites in the spinal dorsal horn after perineural capsaicin treatment in the rat.
The long-term effect of perineural capsaicin treatment on the distribution of substance P (SP) binding sites was studied in the rat spinal dorsal horn using 125I-labelled Bolton-Hunter-SP. Three months after local application of capsaicin onto the sciatic nerve quantitative evaluation of the autoradiograms revealed a significant decrease in the density of SP binding sites of up to 48% in regions of laminae I and II of the spinal dorsal horn somatotopically related to the capsaicin treated sciatic nerve. It is suggested that reduction in SP binding may result from transganglionic and transsynaptic degenerative changes affecting postsynaptic structures. Changes in the distribution of SP binding sites may significantly contribute to functional alterations observed after perineural treatment with capsaicin.
Sann
H
H
MPI für physiologische und klinische Forschung, W.G. Kerckhoff-Institut, Bad Nauheim, Germany.
Jancsó
G
G
Rössler
W
W
Pierau
F K
FK
D000344:Afferent Pathways / Q000502:physiology; D000818:Animals; D001345:Autoradiography; D001665:Binding Sites / Q000187:drug effects; D002211:Capsaicin / Q000494:pharmacology*; D008297:Male; D009416:Nerve Regeneration / Q000502:physiology; D051381:Rats; D017208:Rats, Wistar; D018040:Receptors, Neurokinin-1 / Q000187:drug effects* / Q000378:metabolism; D012584:Sciatic Nerve / Q000187:drug effects / Q000502:physiology; D013116:Spinal Cord / Q000187:drug effects*; D013938:Thymidine Monophosphate / Q000096:biosynthesis
D018040:Receptors, Neurokinin-1; D013938:Thymidine Monophosphate; D002211:Capsaicin