Inhibition of the migrating motor complex by duodenal drainage in man.
The effect of varying bile acid output on fasting small intestinal motility was investigated in healthy male volunteers. Biliary output was manipulated by jejunal infusion of isotonic mannitol, which resulted in increased output, and by prolonged drainage of duodenal contents, which resulted in decreased output. Intestinal motility was measured by manometric recordings performed at four levels in the proximal small intestine. A marker dilution technique was used to measure pancreatico-biliary output. There were three experimental groups: duodenal drainage, non-drainage and control. Both duodenal drainage and non-drainage groups underwent jejunal saline infusion, followed by mannitol infusion. The control group did not receive drainage or infusions. In the drainage group, 0.41 (0.13-0.68) activity fronts of the migrating motor complex (MMC) per hour were recorded during saline infusion, but only 0.06 (0-0.19) activity fronts per hour were observed during mannitol infusion. In the non-drainage group, 0.71 (0.61-0.81) activity fronts per hour were observed during saline infusion and 0.50 (0.18-0.82) activity fronts per hour were recorded during mannitol infusion. In the control group, 0.58 (0.33-0.84) activity fronts per hour were recorded during the first 4-h session and 0.58 (0.45-0.71) activity fronts per hour during the second session. There was no difference between the number of activity fronts per hour observed in the control group and those observed in the saline infusion of the drainage group.(ABSTRACT TRUNCATED AT 250 WORDS)
Nilsson
I
I
Department of Surgery, Karolinska Hospital, Stockholm, Sweden.
Svenberg
T
T
Hedenborg
G
G
Lördal
M
M
Hellström
P M
PM
D000328:Adult; D001647:Bile Acids and Salts / Q000378:metabolism; D004322:Drainage; D004386:Duodenum / Q000502:physiology*; D004395:Dye Dilution Technique; D006801:Humans; D007583:Jejunum / Q000378:metabolism; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D008365:Manometry; D016065:Myoelectric Complex, Migrating / Q000502:physiology*; D010179:Pancreas / Q000187:drug effects / Q000378:metabolism; D011092:Polyethylene Glycols
D001647:Bile Acids and Salts; D008353:Mannitol; D011092:Polyethylene Glycols