Comparison of exogenous surfactants in the treatment of wood smoke inhalation.
The goal of this study was to compare the effectiveness of the exogenous surfactants Infasurf and Exosurf in reestablishing surfactant function inhibited by severe smoke inhalation. Mongrel dogs (n = 17) were anesthetized, placed on a ventilator (40% O2), and surgically prepared for hemodynamic and blood gas measurements; venous admixture (QVA/QT) and static lung compliance (Cstat) were calculated. At the conclusion of the experiment, lung samples were taken for lung water and dynamic surface tension (DST, Wilhelmy balance) measurements. Following baseline measurements, dogs were randomly separated into four groups: Group I, smoke+sham instillation; Group II, smoke+saline instillation: Group III, smoke+Exosurf instillation; and Group IV, smoke+Infasurf instillation. The surfactants (Infasurf and Exosurf, 100 mg/kg) or saline (same volume as surfactants) were instilled into the lungs via suction catheter immediately following smoke exposure. Smoke inhalation caused a similar increase in QVA/QT and fall in PaO2 and Cstat in all groups that improved only with Infasurf instillation (Group IV). DST was significantly improved by Infasurf compared with all other groups. We conclude that Infasurf restores normal DST, inhibited by wood smoke, improving lung function. Exosurf was ineffective in the treatment of wood smoke inhalation.
Nieman
G F
GF
Department of Surgery, State University of New York Health Science Center, Syracuse 13210, USA.
Paskanik
A M
AM
Fluck
R R
RR
Clark
W R
WR
D000818:Animals; D001794:Blood Pressure; D002245:Carbon Dioxide / Q000097:blood; D002263:Carboxyhemoglobin / Q000032:analysis; D002302:Cardiac Output; D004285:Dogs; D015633:Extravascular Lung Water / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects / Q000378:metabolism; D008170:Lung Compliance / Q000187:drug effects; D010100:Oxygen / Q000097:blood; D010108:Oxyhemoglobins / Q000032:analysis; D011663:Pulmonary Surfactants / Q000008:administration & dosage / Q000145:classification / Q000627:therapeutic use*; D015208:Smoke Inhalation Injury / Q000097:blood / Q000188:drug therapy*; D012965:Sodium Chloride; D013500:Surface Tension; D014692:Ventilation-Perfusion Ratio / Q000187:drug effects; D014934:Wood
D010108:Oxyhemoglobins; D011663:Pulmonary Surfactants; D002245:Carbon Dioxide; D012965:Sodium Chloride; D002263:Carboxyhemoglobin; D010100:Oxygen