title: [Concentration of eosinophil cationic protein in blood serum during early and late asthmatic reaction].
abstract: Eosinophil cationic protein (ECP) was measured in blood serum of 15 atopic asthmatics during early (EAR) and late (LAR) asthmatic reaction triggered by specific allergen provocation. Nonspecific bronchial hyperreactivity was evaluated in histamine provocation test before and 48 hours after the allergen challenge. We observed dual asthmatic reaction (DAR) in 8 and an isolated EAR in 7 patients. The ECP serum level and nonspecific bronchial hyperreactivity were significantly higher (p < 0.05) in the DAR group when compared to EAR responders. An inverse correlation between PC20 for histamine and ECP level was shown before and after the allergen challenge in all examined subjects (R = -0.5472, p < 0.05).
authors.affiliation: Katedry i Kliniki Chorób Wewnetrznych i Alergologii AM we Wrocławiu.
authors.forename: M
authors.initials: M
authors.lastname: Wrzyszcz
authors.forename: J
authors.initials: J
authors.lastname: Małolepszy
authors.forename: A
authors.initials: A
authors.lastname: Wolańczyk-Medrala
authors.forename: W
authors.initials: W
authors.lastname: Medrala
authors.forename: M
authors.initials: M
authors.lastname: Kraus-Filarska
authors.forename: E
authors.initials: E
authors.lastname: Liebhart
authors.forename: R
authors.initials: R
authors.lastname: Dobek
mesh_terms: D000328:Adult; D001249:Asthma / Q000097:blood* / Q000175:diagnosis; D001798:Blood Proteins / Q000032:analysis*; D016535:Bronchial Hyperreactivity / Q000175:diagnosis; D001985:Bronchial Provocation Tests; D047091:Eosinophil Granule Proteins; D005260:Female; D006801:Humans; D018836:Inflammation Mediators / Q000097:blood*; D008297:Male; D012129:Respiratory Function Tests; D012260:Ribonucleases
chemical_list: D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D012260:Ribonucleases
vernacular_title: Stezenie eozynofilowego białka kationowego w surowicy podczas wczesnej i późnej reakcji astmatycznej.