A TH1-TH2-like switch in candidiasis: new perspectives for therapy.
An imbalance in TH1-type and TH2-type responses may allow Candida albicans to modify the host response to favor its own persistence. This hypothesis has important consequences for allergy, autoimmunity and co-infection, and also highlights a potential role for cytokine and anti-cytokine therapy in Candida-related pathology.
Puccetti
P
P
Dept of Experimental Medicine, University of Rome Tor Vergata, Italy.
Romani
L
L
Bistoni
F
F
D000818:Animals; D002176:Candida albicans / Q000276:immunology; D002177:Candidiasis / Q000188:drug therapy / Q000276:immunology*; D016207:Cytokines / Q000037:antagonists & inhibitors / Q000276:immunology / Q000627:therapeutic use; D006801:Humans; D007108:Immune Tolerance; D018417:Th1 Cells / Q000276:immunology*; D018418:Th2 Cells / Q000276:immunology*
D016207:Cytokines