title: Seizure-protecting effects of kyotorphin and related peptides in an animal model of epilepsy.
abstract: Administration of peptides kyotorphin (KT), neokyotorphin (NKT), and d-ser-2-NKT into the lateral brain ventricle (10 nmol) increased the latency and attenuated the severity of picrotoxin-induced convulsions in rats. Anticonvulsive effects of the peptides were also observed after their administration into the CA1 hippocampi (2.5, 5, 10 nmol), with the order of potency d-ser-2-NKT-->NKT-->KT. When injected into the substantia nigra reticulata, the 10 nmol dose of NKT and d-ser-2-NKT displayed equal seizure-protecting effect, which was higher than that for KT. It is concluded that kyotorphin and its analogs provide structure-dependent, dose-dependent, and target site-dependent antiepileptic effect.
authors.affiliation: Department of Normal Physiology, Medical Institute, Odessa, Ukraine.
authors.forename: L S
authors.initials: LS
authors.lastname: Godlevsky
authors.forename: A A
authors.initials: AA
authors.lastname: Shandra
authors.forename: I I
authors.initials: II
authors.lastname: Mikhaleva
authors.forename: R S
authors.initials: RS
authors.lastname: Vastyanov
authors.forename: A M
authors.initials: AM
authors.lastname: Mazarati
mesh_terms: D000700:Analgesics / Q000627:therapeutic use*; D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D004305:Dose-Response Relationship, Drug; D004723:Endorphins / Q000627:therapeutic use*; D006624:Hippocampus; D007267:Injections; D007276:Injections, Intraventricular; D008297:Male; D010852:Picrotoxin; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000517:prevention & control*; D013237:Stereoisomerism; D013378:Substantia Nigra
chemical_list: D000700:Analgesics; D000927:Anticonvulsants; D004723:Endorphins; D010852:Picrotoxin; C019448:kyotorphin; C036450:neo-kyotorphin