Inhibitory effect of AL-3264, a new antiallergic agent, on the Prausnitz-Küstner reaction and leukotriene production in monkeys.
To clarify the antiallergic effect and antiallergic mechanism of AL-3264 (N-[4-[4-(diphenylmethyl)-1-piperazinyl]butyl]-3-(6-methyl-3- pyridyl)acrylamide) in monkeys, its effects on the Prausnitz-Küstner (P-K) reaction, the histamine skin reaction and leukotriene production were examined. In contrast to ketotifen and mepyramine, AL-3264 inhibited the P-K reaction, which is mainly mediated by leukotriene and histamine, more clearly than the skin reaction evoked by histamine alone. AL-3264 also inhibited the leukotriene (LT) production in the broncho-alveolar cells, suggesting that the inhibition of LT production actually contributes to the antiallergic effect of AL-3264.
Yakuo
I
I
Department of Pharmacology, Exploratory Research Laboratories, Dainippon Pharmaceutical Co., Ltd., Osaka, Japan.
Ishii
K
K
Sakaki
C
C
Nakamura
H
H
Takeyama
K
K
D000178:Acrylamides / Q000494:pharmacology*; D000485:Allergens / Q000494:pharmacology; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D006632:Histamine; D006634:Histamine H1 Antagonists / Q000494:pharmacology*; D007428:Intradermal Tests; D015289:Leukotrienes / Q000096:biosynthesis*; D008252:Macaca fascicularis; D008297:Male; D010879:Piperazines / Q000494:pharmacology*; D012882:Skin Tests
D000178:Acrylamides; D000485:Allergens; D006634:Histamine H1 Antagonists; D015289:Leukotrienes; D010879:Piperazines; C080363:AL 3264; D006632:Histamine