Antiinflammatory drug effects on bone repair and remodeling in rabbits.
Ketorolac and methylprednisolone effects on bone repair were studied. Demineralized bone matrix was used to graft the defects of rabbits' ulnae. Twenty-seven rabbits were divided into 4 groups: Group A (control group; no drug treatment), Group B (treated with ketorolac 2 mg/kg body weight daily), Group C (treated with ketorolac 4 mg/kg body weight daily), and Group D (treated with methylprednisolone 1 mg/kg body weight weekly). Drug treatment was continued for 6 weeks. The biomechanical results indicated methylprednisolone significantly deteriorated the mechanical properties of the grafted ulnae and the contralateral intact ulnae, although the effects were more pronounced in the grafted side. In Group B, there was minimum effect of ketorolac on the bone properties. In Group C, ketorolac significantly decreased the torsional stiffness and energy absorption of the grafted ulnae and also decreased the maximum torque in the intact and the grafted bones. It was concluded that the inhibitory effect of ketorolac on bone repair was dose dependent. In comparing the effects of ketorolac and methylprednisolone, the latter is more pronounced on torsional stiffness, but the effects on maximum torque and energy absorption were similar to ketorolac. The mechanism of the effects of ketorolac needs additional investigation.
Ho
M L
ML
Departments of Physiology and Orthopaedics, Kaohsiung Medical College, Taiwan, ROC.
Chang
J K
JK
Wang
G J
GJ
D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000494:pharmacology*; D001696:Biomechanical Phenomena; D001857:Bone Matrix / Q000637:transplantation; D001861:Bone Regeneration / Q000187:drug effects*; D016723:Bone Remodeling / Q000187:drug effects*; D016025:Bone Transplantation / Q000502:physiology*; D015232:Dinoprostone / Q000097:blood; D007476:Ionophores; D020910:Ketorolac; D008297:Male; D008775:Methylprednisolone / Q000494:pharmacology*; D011817:Rabbits; D014046:Tolmetin / Q000031:analogs & derivatives* / Q000494:pharmacology; D014457:Ulna / Q000601:surgery
D000894:Anti-Inflammatory Agents, Non-Steroidal; D007476:Ionophores; D014046:Tolmetin; D015232:Dinoprostone; D008775:Methylprednisolone; D020910:Ketorolac