title: [Experimental study of the effectiveness of interleukin-1beta in radiation injury].
abstract: The experiments on mice exposed to radiation (6.5 Gy, LD 80/30) discovered that human recombinant interleukin-1 beta after administration on postradiation hour 1-3 increased the animals' survival by 40-70%. Interleukin-1 beta reduced leukopenia and enhanced the recovery of bone marrow cell elements. The use of the preparation as an early pathogenetic treatment of irradiation damage holds promise.
authors.forename: V I
authors.initials: VI
authors.lastname: Legeza
authors.forename: N G
authors.initials: NG
authors.lastname: Chigareva
authors.forename: N V
authors.initials: NV
authors.lastname: Petkevich
authors.forename: T P
authors.initials: TP
authors.lastname: Vasil'eva
authors.forename: Iu A
authors.initials: IuA
authors.lastname: Abdul'
authors.forename: V N
authors.initials: VN
authors.lastname: Boĭko
mesh_terms: D000818:Animals; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D007375:Interleukin-1 / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use
chemical_list: D007375:Interleukin-1; D011994:Recombinant Proteins
vernacular_title: Eksperimental'noe issledovanie éffektivnosti interleĭkina-1beta pri luchevom porazhenii.