title: Activation of GABA-A receptor by hypotensive drugs.
abstract: Chronic antihypertensive treatment with clonidine and beta-adrenoceptor blockers leads to a significant increase in GABA-A receptor number in the hypothalamus, the pons-medulla and the striatum. The enhancement of receptor number after two beta-blockers was associated with the decrease of Kd factor in the pons-medulla and the striatum. There was no change in receptor affinity after clonidine. We conclude that neurotransmission via GABA-A receptors is important for the hypotensive effects of clonidine and some beta-adrenoceptor blockers.
authors.affiliation: Department of Pharmacology, Drug Institute, Warsaw, Poland.
authors.forename: M
authors.initials: M
authors.lastname: Remiszewska
authors.forename: Z
authors.initials: Z
authors.lastname: Jastrzebski
authors.forename: H
authors.initials: H
authors.lastname: Czyzewska-Szafran
authors.forename: J S
authors.initials: JS
authors.lastname: Skierski
mesh_terms: D000818:Animals; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D004334:Drug Administration Schedule; D008297:Male; D051381:Rats; D011918:Rats, Inbred SHR; D011963:Receptors, GABA-A / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*
chemical_list: D000959:Antihypertensive Agents; D011963:Receptors, GABA-A