How safe are the xenogeneic hemostats?--Report of a case of severe systemic allergic reaction.
We report herein the unusual case of a 55-year-old woman who developed a severe systemic allergy to Avitene (microfibrillar collagen hydrochloride), a xenogeneic agent sometimes used for topical hemostasis in laparoscopic cholecystectomy. The patient developed fever, general fatigue, mild liver dysfunction, and prominent eosinophilia postoperatively. A skin allergy test confirmed that these abnormal findings were attributable to an allergic reaction to Avitene.
Kitamura
K
K
First Department of Surgery, Kyoto Prefectural University of Medicine, Japan.
Yasuoka
R
R
Ohara
M
M
Shimotsuma
M
M
Hagiwara
A
A
Yamane
T
T
Yamaguchi
T
T
Takahashi
T
T
D018784:Abdominal Abscess / Q000175:diagnosis; D017081:Cholecystectomy, Laparoscopic; D003094:Collagen / Q000009:adverse effects*; D003937:Diagnosis, Differential; D004342:Drug Hypersensitivity / Q000175:diagnosis; D005260:Female; D006488:Hemostasis, Surgical; D006490:Hemostatics / Q000009:adverse effects*; D006801:Humans; D008875:Middle Aged; D011183:Postoperative Complications / Q000175:diagnosis
D006490:Hemostatics; D003094:Collagen