title: [Hemostatic factors and family history of thrombosis in patients with a myocardial infarct: a case-control study. The participants in GISSI-2-Efrim. Gruppo Italiano per lo Studio della Streptochinasi nell'Infarto Miocardico].
abstract: We studied a series of hemostasis factors in a group of patients selected from a cohort of 916 patients affected by MI from the GISSI-2 study population. Following a case-control design, 73 patients with a family history of thrombosis (the presence of at least two first degree relatives affected by MI and/or stroke before 65 years) were matched with MI patients with no family history of thrombosis. Blood collection could be performed 6 +/- 1 months after the acute phase following MI in 53 pairs of such patients. The presence of mixed disulphides (MDS) was significantly higher in patients with family history than in controls; MDS were detected in 7 cases and only in 1 control. No difference was found in contrast in the distribution of fibrinogen, factor VII, factor VIII, vWF, protein C, protein S, AT III, HC II, PAI-1, lipoprotein (a). Nevertheless, independently from the family history, in the whole population of MI patients studied, 21 cases of suspected deficiency of protein C were found. Sixteen out of 53 patients with family history of MI and/or stroke had a family history of MI only. In patients with family history of MI the t-PA antigen levels were significantly lower than in the control group (7.5 +/- 4.4 vs 11.1 +/- 3.5 ng/ml, t = -2.6, p < 0.02). In the whole population of MI patients and in patients with a family history of thrombosis t-PA antigen was positively correlated with PAI-1 antigen and vWF. The correlation with PAI-1 was lost in patients with family history of MI.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Istituto di Ricerche Farmacologiche Mario Negri, Consorzio Mario Negri Sud, Santa Maria Imbaro.
authors.forename: L
authors.initials: L
authors.lastname: Iacoviello
authors.forename: M C
authors.initials: MC
authors.lastname: Roncaglioni
authors.forename: C
authors.initials: C
authors.lastname: Amore
authors.forename: R M
authors.initials: RM
authors.lastname: Marfisi
authors.forename: A
authors.initials: A
authors.lastname: Celardo
authors.forename: G
authors.initials: G
authors.lastname: Feruglio
authors.forename: M G
authors.initials: MG
authors.lastname: Franzosi
authors.forename: G
authors.initials: G
authors.lastname: Tognoni
authors.forename: A
authors.initials: A
authors.lastname: Maseri
authors.forename: M B
authors.initials: MB
authors.lastname: Donati
mesh_terms: D000704:Analysis of Variance; D015415:Biomarkers / Q000097:blood; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D005260:Female; D006487:Hemostasis; D006801:Humans; D007558:Italy / Q000453:epidemiology; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*; D013927:Thrombosis / Q000097:blood* / Q000453:epidemiology / Q000235:genetics*
chemical_list: D015415:Biomarkers
vernacular_title: Fattori dell'emostasi e storia familiare di trombosi in pazienti con infarto del miocardio: studio caso-controllo. I patecipanti al GISSI-2-Efrim.