title: Immunogenic and non-immunogenic hyperthyroidism. Recent trends in prealpine Switzerland and in coastal Poland.
abstract: Annual occurrences of immunogenic (IH) and non-immunogenic hyperthyroidism (NIH) between Berne (1976, 1982, 1991) and Szczecin (1973, 1980, 1991) were compared. Out of 21,025 patients referred for thyroid examinations, 10.1% (average) were hyperthyroid. In Berne (former endemic goiter region) and Szczecin (without goiter endemicity) IH occurred in 41% and 68%, NIH in 59% and 32% of hyperthyroid patients, respectively. Within a stable incidence of NIH in Berne, toxic adenomas (TA) decreased from 41% (1976) to 17% (1991) (p < 0.005). In Szczecin, where iodine deficiency is in an early stage, the TA frequency did not change significantly: from 24% (1973) to 28% (1991). Increases of TA or of multifocal functional autonomy apparently "mark" incipient or, respectively, decreasing deficiencies in nutritious iodine. Hyperthyroid patients in Berne compared to Szczecin were older, both with IH (54 versus 45 y) and NIH (65 versus 52 y). Age at diagnosis was stable in Berne but increasing (p < 0.05) in Szczecin (from 43 to 52 y).
authors.affiliation: Department of Nuclear Medicine, University of Berne, Inselspital, Switzerland.
authors.forename: C
authors.initials: C
authors.lastname: Als
authors.forename: M
authors.initials: M
authors.lastname: Listewnik
authors.forename: H
authors.initials: H
authors.lastname: Rösler
authors.forename: E
authors.initials: E
authors.lastname: Bartkowiak
mesh_terms: D000236:Adenoma / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D000328:Adult; D000367:Age Factors; D000368:Aged; D006111:Graves Disease / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D006801:Humans; D006980:Hyperthyroidism / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology*; D015994:Incidence; D008875:Middle Aged; D011044:Poland / Q000453:epidemiology; D012189:Retrospective Studies; D013557:Switzerland / Q000453:epidemiology; D013964:Thyroid Neoplasms / Q000097:blood / Q000175:diagnosis / Q000453:epidemiology; D013972:Thyrotropin / Q000097:blood; D013973:Thyrotropin-Releasing Hormone; D013974:Thyroxine / Q000097:blood; D014284:Triiodothyronine / Q000097:blood
chemical_list: D014284:Triiodothyronine; D013973:Thyrotropin-Releasing Hormone; D013972:Thyrotropin; D013974:Thyroxine