65Zn uptake by liver of rats fed 3'-methyl-dimethylaminoazobenzene.
The uptake of 65Zn, determined by gamma-counting and also by autoradiography, significantly increased with the increasing level of metallothionein in liver 4 weeks after the start of feeding a diet containing 3'-methyl-dimethylaminoazobenzene (3'-Me-DAB), at which time the serum gamma-glutamyl transpeptidase activity was not yet significantly elevated. At this time, furthermore, hepatic uptake of 67Ga-citrate did not increase and that of 99mTc-Sn-colloid decreased in 3'-Me-DAB-fed rats. These results suggest that a short-life gamma-emitting isotope such as 69mZn may be useful for the detection at the early stage of hepatic carcinogenesis.
Takeda
A
A
Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
Tamano
H
H
Ohnuma
M
M
Okada
S
S
D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography; D002712:Chlorides / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D008668:Metallothionein / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D017967:Zinc Compounds / Q000493:pharmacokinetics; D015037:Zinc Radioisotopes / Q000493:pharmacokinetics*; D004124:p-Dimethylaminoazobenzene / Q000633:toxicity*
D002712:Chlorides; D017967:Zinc Compounds; D015037:Zinc Radioisotopes; C016837:zinc chloride; D008668:Metallothionein; D004124:p-Dimethylaminoazobenzene