title: Different internal metabolites trigger the induction of glycolytic gene expression in Saccharomyces cerevisiae.
abstract: In the yeast Saccharomyces cerevisiae, the sugar-induced expression of various genes coding for glycolytic enzymes is triggered by increases in the concentrations of different internal metabolites. Here, we show that the induction of the glycolytic isoenzyme enolase 2 is strictly dependent on the abilities of different mutant strains to increase the level of glucose-6-phosphate after the addition of sugars. In contrast, the induction of alcohol dehydrogenase I is dependent on increasing concentrations of metabolites in the late stages of glycolysis.
authors.affiliation: Institut für Mikrobiologie, Technische Hochschule Darmstadt, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Müller
authors.forename: E
authors.initials: E
authors.lastname: Boles
authors.forename: M
authors.initials: M
authors.lastname: May
authors.forename: F K
authors.initials: FK
authors.lastname: Zimmermann
mesh_terms: D000426:Alcohol Dehydrogenase / Q000096:biosynthesis / Q000235:genetics; D050260:Carbohydrate Metabolism; D002241:Carbohydrates / Q000235:genetics*; D004790:Enzyme Induction / Q000235:genetics; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D015971:Gene Expression Regulation, Enzymologic / Q000502:physiology*; D005947:Glucose / Q000378:metabolism; D006019:Glycolysis / Q000235:genetics*; D008958:Models, Molecular; D010751:Phosphopyruvate Hydratase / Q000096:biosynthesis / Q000235:genetics; D012441:Saccharomyces cerevisiae / Q000201:enzymology / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics
chemical_list: D002241:Carbohydrates; D000426:Alcohol Dehydrogenase; D010751:Phosphopyruvate Hydratase; D005947:Glucose