Linkage of the angiotensinogen gene locus to human essential hypertension in African Caribbeans.
The renin-angiotensin system regulates blood pressure and sodium balance. The angiotensinogen gene which encodes the key substrate within this system has been linked to essential hypertension in White Europeans. It has been suggested that people of West African ancestry may have a different genetic basis for hypertension. In this study we have tested whether there is linkage of the angiotensinogen gene to essential hypertension in African Caribbeans from St. Vincent and the Grenadines. DNA from 63 affected sibling pairs with hypertension was tested for linkage by analyzing whether there was excess allele sharing among siblings genotyped using an angiotensinogen dinucleotide repeat sequence. There was significant support for linkage (T = 3.07, P = 0.001) and association of this locus to hypertension (chi 2 = 50.2, 12 degrees of freedom, P << 0.001). A DNA polymorphism which alters methionine to threonine at position 235 (M235T) within the angiotensinogen peptide has been associated previously with hypertension. However, we found no association of this variant with hypertension in this study. These findings provide support for linkage and association of the angiotensinogen locus to hypertension in African Caribbeans and suggest some similarities in the genetic basis of essential hypertension in populations of different ethnicity.
Caulfield
M
M
Department of Clinical Pharmacology, St. Bartholomew's Hospital, London, United Kingdom.
Lavender
P
P
Newell-Price
J
J
Farrall
M
M
Kamdar
S
S
Daniel
H
H
Lawson
M
M
De Freitas
P
P
Fogarty
P
P
Clark
A J
AJ
D000328:Adult; D000349:Africa / Q000208:ethnology; D000368:Aged; D000428:Alcohol Drinking / Q000453:epidemiology; D000483:Alleles; D000808:Angiotensinogen / Q000235:genetics*; D044383:Black People / Q000235:genetics*; D001786:Blood Glucose / Q000032:analysis; D015992:Body Mass Index; D005260:Female; D008040:Genetic Linkage; D006801:Humans; D006973:Hypertension / Q000453:epidemiology / Q000208:ethnology* / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D009679:Nuclear Family; D009841:Oligonucleotides; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid; D012307:Risk Factors; D014900:West Indies / Q000453:epidemiology
D001786:Blood Glucose; D009841:Oligonucleotides; D000808:Angiotensinogen