title: Hemolytic anemia following high-dose intravenous immunoglobulin administration.
abstract: We describe two cases of hemolytic anemia following high-dose intravenous human immunoglobulin administration in young females with idiopathic thrombocytopenic purpura. Inducement of hemolytic anemia by anti-A and anti-B antibodies in these cases necessitates the performance of a minor crossmatching procedure prior to immunoglobulin use to prevent the occurrence of this adverse reaction.
authors.affiliation: Division of Pediatrics, Tachikawa Kyosai Hospital (Federation of National Public Service and Affiliated Personnel Mutual Aid Associations), Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Tamada
authors.forename: M
authors.initials: M
authors.lastname: Kohga
authors.forename: H
authors.initials: H
authors.lastname: Masuda
authors.forename: K
authors.initials: K
authors.lastname: Hattori
mesh_terms: D000743:Anemia, Hemolytic / Q000209:etiology*; D001788:Blood Grouping and Crossmatching; D002648:Child; D003298:Coombs Test; D005260:Female; D006801:Humans; D007074:Immunoglobulin G / Q000008:administration & dosage / Q000009:adverse effects* / Q000097:blood; D007262:Infusions, Intravenous; D016553:Purpura, Thrombocytopenic, Idiopathic / Q000628:therapy*
chemical_list: D007074:Immunoglobulin G