title: [Respiratory burst of neutrophils and cytokine profile in the non-insulin-dependent diabetic].
abstract: Many clinical and experimental data are in favour of a participation of leukocytes in vascular disease. Diabetes, a risk factor, is associated with a dysfunction of neutrophils. If chemotaxis and phagocytosis are deficient, it is not clearly established whether superoxide generation is conserved in these patients. We have measured this function in 35 noninsulin dependent diabetic patients, compared with a control population. We have assessed, in parallel, a profile of the cytokines involved in vascular phenomenons including TNF alpha, IL-1 beta et IL-6. Our results indicate that the generation of free radicals is normal in diabetics, with a significant elevation of TNF alpha. These results suggest a possible participation of this cytokine in the modulation of granulocyte reactivity.
authors.affiliation: Laboratoire central d'Hématologie, CHU Robert-Debré, Reims.
authors.forename: P
authors.initials: P
authors.lastname: Nguyen
authors.forename: V
authors.initials: V
authors.lastname: Durlach
authors.forename: M
authors.initials: M
authors.lastname: Leutenegger
authors.forename: M
authors.initials: M
authors.lastname: Guenounou
authors.forename: G
authors.initials: G
authors.lastname: Potron
mesh_terms: D000328:Adult; D000368:Aged; D016022:Case-Control Studies; D016207:Cytokines / Q000097:blood*; D003924:Diabetes Mellitus, Type 2 / Q000097:blood*; D003925:Diabetic Angiopathies / Q000097:blood*; D005069:Evaluation Studies as Topic; D005609:Free Radicals; D006801:Humans; D007375:Interleukin-1 / Q000097:blood; D015850:Interleukin-6 / Q000097:blood; D008875:Middle Aged; D009504:Neutrophils / Q000378:metabolism*; D016897:Respiratory Burst / Q000502:physiology*; D012307:Risk Factors; D013481:Superoxides / Q000378:metabolism; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism
chemical_list: D016207:Cytokines; D005609:Free Radicals; D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha; D013481:Superoxides
vernacular_title: Explosion respiratoire des polynucléaires neutrophiles et profil des cytokines chez le diabétique non insulinodépendant.