title: Mutations that affect the length, fasciculation, or ventral orientation of specific sensory axons in the Drosophila embryo.
abstract: In wild-type Drosophila embryos, five lateral chordotonal (lch) axons in each abdominal hemisegment originate from a midlaterally positioned cluster of neurons and grow, fasciculate, and orient ventrally as they connect with targets in the CNS. We have identified 22 recessive lethal mutations in 12 complementation groups, 8 of which are novel, that differentially affect lch axon growth, fasciculation, or ventral orientation. Mutations in 3 loci result in shorter, but fasciculated and ventrally directed axon bundles. Mutations in 4 complementation groups cause lch axon defasciculation. Mutations in 7 complementation groups cause some lch axon bundles to grow dorsally along a trajectory 180 degrees from normal.
authors.affiliation: Howard Hughes Medical Institute, Department of Physiology, University of California, San Francisco 94143-0724, USA.
authors.forename: P A
authors.initials: PA
authors.lastname: Kolodziej
authors.forename: L Y
authors.initials: LY
authors.lastname: Jan
authors.forename: Y N
authors.initials: YN
authors.lastname: Jan
mesh_terms: D000818:Animals; D001369:Axons / Q000648:ultrastructure*; D048429:Cell Size; D004331:Drosophila melanogaster / Q000196:embryology / Q000235:genetics* / Q000648:ultrastructure; D005260:Female; D017344:Genes, Insect; D005804:Genes, Lethal; D005808:Genes, Recessive; D005816:Genetic Complementation Test; D005821:Genetic Techniques; D008297:Male; D009024:Morphogenesis / Q000235:genetics; D009154:Mutation; D009475:Neurons, Afferent / Q000648:ultrastructure*