title: Localization of a gene for partial epilepsy to chromosome 10q.
abstract: There is strong evidence for a genetic contribution to epilepsy, but it is commonly assumed that this genetic contribution is limited to 'generalized' epilepsies, and that most forms of 'partial' epilepsy are nongenetic. In a linkage analysis of a single family containing 11 affected individuals, we obtained strong evidence for localization of a gene for partial epilepsy. This susceptibility gene maps to chromosome 10q, with a maximum two-point lod score for D10S192 of 3.99 at theta = 0.0. All affected individuals share a single haplotype for seven tightly linked contiguous markers; the maximum lod score for this haplotype is 4.83 at theta = 0.0. Key recombinants place the susceptibility locus within a 10 centimorgan interval.
authors.affiliation: G. H. Sergievsky Center, School of Public Health, Columbia University, New York, New York 10032, USA.
authors.forename: R
authors.initials: R
authors.lastname: Ottman
authors.forename: N
authors.initials: N
authors.lastname: Risch
authors.forename: W A
authors.initials: WA
authors.lastname: Hauser
authors.forename: T A
authors.initials: TA
authors.lastname: Pedley
authors.forename: J H
authors.initials: JH
authors.lastname: Lee
authors.forename: C
authors.initials: C
authors.lastname: Barker-Cummings
authors.forename: A
authors.initials: A
authors.lastname: Lustenberger
authors.forename: K J
authors.initials: KJ
authors.lastname: Nagle
authors.forename: K S
authors.initials: KS
authors.lastname: Lee
authors.forename: M L
authors.initials: ML
authors.lastname: Scheuer
mesh_terms: D000293:Adolescent; D000328:Adult; D002874:Chromosome Mapping; D002879:Chromosomes, Human, Pair 10; D004828:Epilepsies, Partial / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D010375:Pedigree
chemical_list: D005819:Genetic Markers