[Allopurinol hypersensitivity. A possible cause of hepatitis and mucocutaneous eruptions in a patient undergoing antitubercular treatment].
The authors describe a case of drug-induced cytolytic hepatitis probably secondary to hypersensitivity to allopurinol which was prescribed incorrectly for secondary hyperuricaemia during treatment with pyrazinamide. The diagnosis was reviewed in view of the late occurrence of hepatitis in relation to the onset of the antituberculous treatment, the absence of a viral aetiology and the presence of clinical manifestations, biological and histological features which were compatible with hypersensitivity to allopurinol. The authors recalled that the type of uricaemia induced by pyrazinamide is most often asymptomatic and does not require any treatment with uric acid lowering drugs. Cessation of pyrazinamide is justified in cases of symptomatic hyperuricaemia but when the indications for pyrazinamide are imperative, treatment with an eliminator of uric acid is indicated. Allopurinol is contra-indicated in association with pyrazinamide on account of its inhibitory reaction to xanthine oxidase. Xanthine oxidase decreases the level pyrazinoic acid, a metabolite of pyrazinamide, which is responsible for the inhibition of the tubular secretion of uric acid.
Urban
T
T
Service de Pneumologie, Hôpital Saint-Antoine, Paris.
Maquarre
E
E
Housset
C
C
Chouaid
C
C
Devin
E
E
Lebeau
B
B
D000328:Adult; D000493:Allopurinol / Q000009:adverse effects*; D056486:Chemical and Drug Induced Liver Injury / Q000209:etiology*; D003875:Drug Eruptions / Q000209:etiology*; D004342:Drug Hypersensitivity / Q000209:etiology*; D004347:Drug Interactions; D006801:Humans; D008297:Male; D011718:Pyrazinamide / Q000009:adverse effects*; D014397:Tuberculosis, Pulmonary / Q000188:drug therapy*; D014527:Uric Acid / Q000097:blood / Q000652:urine
D014527:Uric Acid; D011718:Pyrazinamide; D000493:Allopurinol
Hypersensibilité à l'allopurinol. Une cause possible d'hépatite et d'éruption cutanéo-muqueuse chez un patient sous antituberculeux.