[Estrogens, left ventricular function and coronary circulation: what are the possibilities of therapeutic use?].
Low-dose estrogen replacement therapy should be recommended to post-menopausal women, especially if they suffer from circulatory disorders, because it significantly reduces cardiovascular risk. Low-dose estrogens favourably affects lipid profile, without causing a significant increase of thrombotic risk: atherosclerosis is therefore prevented. Estrogen can augment coronary flow by the relaxation of vascular smooth-muscular cells. Finally, estrogen can improve left ventricle systolic and diastolic function, delaying the physiological aging process.
Ducceschi
V
V
Istituto Medico-Chirurgico di Cardiologia, Facoltà di Medicina e Chirurgia, II Università degli Studi, Napoli.
Sarubbi
B
B
Russo
B
B
Di Micco
G
G
Iacono
A
A
D000328:Adult; D000375:Aging / Q000187:drug effects; D000818:Animals; D001161:Arteriosclerosis / Q000517:prevention & control; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000517:prevention & control; D004305:Dose-Response Relationship, Drug; D015914:Estrogen Replacement Therapy; D004967:Estrogens / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D005260:Female; D000882:Haplorhini; D006801:Humans; D006937:Hypercholesterolemia / Q000150:complications; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000517:prevention & control; D012307:Risk Factors; D013927:Thrombosis / Q000517:prevention & control; D016277:Ventricular Function, Left / Q000187:drug effects*
D004967:Estrogens
Estrogeni, funzione ventricolare sinistra e circolo coronarico: quali possibilità di impiego in campo terapeutico?