title: [Clinical study of improving effect of shuxinyin on abnormal left ventricular diastolic function in coronary heart disease].
abstract: There was evidence that abnormal left ventricular diastolic function was common in patients with coronary heart disease which led to symptoms such as dyspnea on exertion, distress in chest etc, even overt congestive heart failure. The changes of left ventricular diastolic function were examined with pulsed doppler echocardiography as well as of clinical symptoms, signs, electrocardiographic findings and plasma lipoprotein after Shuxinyin (SXY) therapy in 31 patients with coronary heart disease and abnormal left ventricular diastolic function. The SXY mainly consists of medicinal herbs capable of tonifying Qi and Yin. After treatment for one month the symptoms, signs and ECG were improved, the symptomatic effective rate was 87.1%. Plasma lipoprotein was reduced (P < 0.05). The main changes in doppler echocardiography were as follows. The peak of E wave, the area of E wave and Dec rate increased significantly (P < 0.01). The ratio of A wave peak to E wave peak was decreased. The changes in peak of A wave, the area of A wave and time index were insignificant (P > 0.05). It was concluded that SXY mainly improved the early left ventricular diastolic functions, increased the peak velocity and volume of rapid left ventricular filling blood flow during the early diastole, and thus alleviated symptoms as well as ECG findings.
authors.affiliation: Longhua Hospital, Shanghai University of TCM.
authors.forename: W
authors.initials: W
authors.lastname: Chen
authors.forename: Y
authors.initials: Y
authors.lastname: He
authors.forename: Z X
authors.initials: ZX
authors.lastname: Lin
mesh_terms: D000368:Aged; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D003971:Diastole / Q000187:drug effects; D004365:Drugs, Chinese Herbal / Q000494:pharmacology / Q000627:therapeutic use*; D018619:Echocardiography, Doppler, Pulsed; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D016277:Ventricular Function, Left / Q000187:drug effects*
chemical_list: D004365:Drugs, Chinese Herbal