title: Chronic pancreatitis caused by an autoimmune abnormality. Proposal of the concept of autoimmune pancreatitis.
abstract: Several authors have reported a case of chronic pancreatitis associated with Sjögren's syndrome in which an autoimmune mechanism may have been involved in the etiology and in which steroid therapy was effective. We recently encountered a patient with pancreatitis who had hyperglobulinemia, was autoantibody-positive, and responded to steroid therapy. This patient, however, failed to show any evidence of association with Sjögren's syndrome or other collagen diseases. Although the concept of autoimmune hepatitis and the criteria for diagnosing it have been established, autoimmune pancreatitis has not yet been defined as a clinical entity. We report a case of chronic pancreatitis in which an autoimmune mechanism is involved in the etiology and summarize the cases of pancreatitis suspected of being caused by an autoimmune mechanism in the Japanese and English literature.
authors.affiliation: Institute of Gastroenterology, Tokyo Women's Medical College, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yoshida
authors.forename: F
authors.initials: F
authors.lastname: Toki
authors.forename: T
authors.initials: T
authors.lastname: Takeuchi
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: K
authors.initials: K
authors.lastname: Shiratori
authors.forename: N
authors.initials: N
authors.lastname: Hayashi
mesh_terms: D000368:Aged; D001323:Autoantibodies / Q000032:analysis; D001327:Autoimmune Diseases / Q000150:complications*; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006942:Hypergammaglobulinemia / Q000150:complications; D010195:Pancreatitis / Q000188:drug therapy / Q000209:etiology*; D011239:Prednisolone / Q000627:therapeutic use
chemical_list: D001323:Autoantibodies; D011239:Prednisolone