[Effects of a number of cytokines on the proliferation of mesangial cells and the production of extracellular matrix in anti-GBM nephritis].
The interaction of IL-1 and TNF alpha in the autolous phase of anti-GBM nephritis was studied. The influx of mononuclear leukocytes into the glomerulus and high cytokine levels induced a decrease in mesangial cell proliferation and an increase in extracellular matrix production. The methylprednisolone suppression of mononuclear leukocyte infiltration caused the autocine cytokine secretion of mesangial cells. Cyclophosphamide decreased cytokine production, but did not affect mononuclear leukocyte infiltration. The absence of mononuclear leukocytes in the site of the injury induced by imbalance between the synthesis and degradation of extracellular matrix components. The uncontrolled metabolism of the extracellular matrix may be induced glomerulosclerosis.
Ivanov
A A
AA
Gladskikh
O P
OP
Shilov
E M
EM
Gitel'
E P
EP
Meshcheriakova
M A
MA
Pal'tsev
M A
MA
D000818:Animals; D001485:Basement Membrane / Q000276:immunology*; D002455:Cell Division; D002478:Cells, Cultured; D016207:Cytokines / Q000276:immunology*; D005109:Extracellular Matrix / Q000378:metabolism; D005920:Glomerular Mesangium / Q000166:cytology* / Q000187:drug effects; D007678:Kidney Glomerulus / Q000187:drug effects / Q000276:immunology*; D008775:Methylprednisolone / Q000494:pharmacology; D009393:Nephritis / Q000276:immunology* / Q000473:pathology; D009400:Nephrosclerosis / Q000209:etiology; D051381:Rats; D017208:Rats, Wistar
D016207:Cytokines; D008775:Methylprednisolone
Vliianie riada tsitokinov na proliferatsiiu mezangial'nykh kletok i produktsiiu vnekletochnogo matriksa pri anti-GBM-nefrite.