A novel bacteristatic action of bovine and porcine serum that is reversed by norepinephrine.
A previously unreported anti-bacterial activity against Escherichia coli has been found in porcine and bovine sera, but not in human or chicken sera. The activity is not affected by heat inactivation of the complement system, and is bacteriostatic rather than bactericidal. Growth inhibition is reversible by addition of norepinephrine.
Lenard
J
J
University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Department of Physiology and Biophysics, Piscataway 08854-5635, USA.
VanDeroef
R
R
D000818:Animals; D001770:Blood Bactericidal Activity / Q000187:drug effects*; D002417:Cattle; D002455:Cell Division / Q000187:drug effects; D004926:Escherichia coli / Q000187:drug effects / Q000254:growth & development*; D009638:Norepinephrine / Q000494:pharmacology*; D013552:Swine
D009638:Norepinephrine