Normal concentrations of serum insulin-like growth factor-1 in late polio.
A recent study of 10 men with postpolio syndrome indicated a low secretion of growth hormone (GH) as reflected by serum insulin-like growth factor-I (IGF-1). Therefore, 87 patients were studied, 17 to 71 years after acute poliomyelitis, of whom 65% reported the occurrence of new or increased weakness (ie, during the last 2 years) in muscles previously affected by polio. Serum IGF-1 concentrations in the patients were compared with those found in a reference population comprising 392 randomly selected individuals. No differences from the reference population values were observed. No correlation was found between IGF-1 concentrations and the severity of the original polio affliction, the recovery status, the need for ambulation aids, or the presence of new symptoms. The results do not indicate a need for GH substitution treatment of patients with postpolio syndrome.
Sunnerhagen
K S
KS
Department of Rehabilitation Medicine, Sahlgrenska University Hospital, University of Göteborg, Sweden.
Bengtsson
B A
BA
Lundberg
P A
PA
Landin
K
K
Lindstedt
G
G
Grimby
G
G
D000203:Activities of Daily Living; D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000032:analysis*; D008297:Male; D008875:Middle Aged; D016262:Postpoliomyelitis Syndrome / Q000097:blood*; D013739:Testosterone / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood
D013963:Thyroid Hormones; D013739:Testosterone; D007334:Insulin-Like Growth Factor I