Transforming growth factor alpha.
Transforming growth factor alpha (TGF alpha) is a close relative of epidermal growth factor (EGF), the first polypeptide mitogen discovered in 1962 (Cohen, 1962). TGF alpha, like EGF, exerts its effect on cells through binding to the EGF-Receptor (EGF-R). Here we review the molecular and cell biology of TGF alpha before proceeding to describe our own work on signaling molecules induced in response to activation of the EGF-R.
Kumar
V
V
Academic Surgical Unit, London Hospital Medical College, UK.
Bustin
S A
SA
McKay
I A
IA
D000595:Amino Acid Sequence; D000818:Animals; D002471:Cell Transformation, Neoplastic; D004815:Epidermal Growth Factor / Q000737:chemistry; D066246:ErbB Receptors / Q000502:physiology*; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D017433:Protein Structure, Secondary; D011565:Psoriasis / Q000473:pathology / Q000503:physiopathology; D015398:Signal Transduction; D016211:Transforming Growth Factor alpha / Q000737:chemistry / Q000235:genetics / Q000502:physiology*; D018631:ras Proteins / Q000502:physiology
D016211:Transforming Growth Factor alpha; D004815:Epidermal Growth Factor; D066246:ErbB Receptors; D018631:ras Proteins