title: Invasive adenocarcinoma of the cervix following LLETZ (large loop excision of the transformation zone) for adenocarcinoma in situ.
abstract: Adenocarcinoma in situ (AIS) of the cervix is a controversial entity which is being encountered with increasing frequency. Current critical issues in its management are the safety of uterine preservation in younger patients and the use of LLETZ conization. A 28-year-old patient was diagnosed with AIS and managed with LLETZ. Despite apparently negative margins of resection in the initial conizations, the patient was found to have invasive adenocarcinoma 1 year later. It is concluded, after review of the pathologic features of AIS, that if conservative management of AIS is elected, then standard cold knife conization should be performed and not LLETZ. Further study is required to establish the overall safety of conservative treatment of cervical AIS, including the use of LLETZ.
authors.affiliation: Department of Gynecology, Cleveland Clinic Foundation, Ohio 44195, USA.
authors.forename: A W
authors.initials: AW
authors.lastname: Kennedy
authors.forename: G H
authors.initials: GH
authors.lastname: elTabbakh
authors.forename: C V
authors.initials: CV
authors.lastname: Biscotti
authors.forename: S
authors.initials: S
authors.lastname: Wirth
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology / Q000601:surgery*; D000328:Adult; D002278:Carcinoma in Situ / Q000473:pathology / Q000601:surgery*; D004598:Electrosurgery / Q000379:methods; D005260:Female; D006801:Humans; D009361:Neoplasm Invasiveness; D002583:Uterine Cervical Neoplasms / Q000473:pathology / Q000601:surgery*