title: Early afterdepolarization abolished by potassium channel opener in a patient with idiopathic long QT syndrome.
abstract: We describe a 17-year-old boy with idiopathic long QT syndrome and repeated syncopal episodes. Early afterdepolarization (EAD) in the monophasic action potential (MAP) was demonstrated in the posterior septum of the left ventricle. Injection of the potassium channel opener nicorandil decreased EAD and shortened MAP duration. The syncopal episodes due to ventricular fibrillation disappeared after administration of the potassium channel opener.
authors.affiliation: Department of Cardiovascular Medicine, Okayama University, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Sato
authors.forename: Y
authors.initials: Y
authors.lastname: Hata
authors.forename: M
authors.initials: M
authors.lastname: Yamamoto
authors.forename: H
authors.initials: H
authors.lastname: Morita
authors.forename: K
authors.initials: K
authors.lastname: Mizuo
authors.forename: H
authors.initials: H
authors.lastname: Yamanari
authors.forename: D
authors.initials: D
authors.lastname: Saito
authors.forename: T
authors.initials: T
authors.lastname: Ohe
mesh_terms: D000200:Action Potentials / Q000187:drug effects; D000293:Adolescent; D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use*; D004562:Electrocardiography / Q000187:drug effects; D006801:Humans; D008133:Long QT Syndrome / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D009536:Niacinamide / Q000031:analogs & derivatives* / Q000627:therapeutic use; D020108:Nicorandil; D015221:Potassium Channels / Q000187:drug effects*; D013575:Syncope / Q000188:drug therapy / Q000209:etiology* / Q000503:physiopathology
chemical_list: D000889:Anti-Arrhythmia Agents; D015221:Potassium Channels; D009536:Niacinamide; D020108:Nicorandil