title: Direct effect of calcitriol on the regulation of parathyroid hormone secretion in a case of pseudo-hypoparathyroidism (a 24-month follow-up study).
abstract: The diagnosis of pseudohypoparathyroidism with osteitis fibrosa was made in a 51-year-old woman on the basis of hypocalcaemia, elevated plasma PTH (1-84) and blunted cAMP response to hPTH infusion. Radiologically, widespread signs of hyperparathyroidism were observed and quantitative histomorphometry confirmed the increased bone cellular turnover. Treatment with calcitriol (1,25 dihydroxyvitamin D3) induced a dramatic improvement of bone lesions. During treatment PTH (1-84) normalized with high dosage of calcitriol in spite of low or subnormal levels of serum calcium, and subsequently increased for each reduction of calcitriol dosage despite normal calcium levels. Our observations support a major and direct effect of 1,25 dihydroxyvitamin D3 on the regulation of parathyroid secretion of parathyroids glands.
authors.affiliation: Department of Rheumatology, CHU Angers, France.
authors.forename: P
authors.initials: P
authors.lastname: Giraud
authors.forename: M
authors.initials: M
authors.lastname: Audran
authors.forename: V
authors.initials: V
authors.lastname: Rohmer
authors.forename: P
authors.initials: P
authors.lastname: Jallet
authors.forename: M F
authors.initials: MF
authors.lastname: Basle
authors.forename: C
authors.initials: C
authors.lastname: Bregeon
authors.forename: J C
authors.initials: JC
authors.lastname: Bigorgne
mesh_terms: D001706:Biopsy; D002117:Calcitriol / Q000627:therapeutic use*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007085:Ilium / Q000473:pathology; D008875:Middle Aged; D010002:Osteitis Fibrosa Cystica / Q000150:complications / Q000000981:diagnostic imaging; D010281:Parathyroid Hormone / Q000378:metabolism*; D011547:Pseudohypoparathyroidism / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism*; D011859:Radiography
chemical_list: D010281:Parathyroid Hormone; D002117:Calcitriol