A non-ionic water-soluble pentaphyrin derivative. Synthesis and cytotoxicity.
The synthesis of the water soluble tetrahydroxypentaphyrin derivative, 1, is described. This species, which forms complexes with both small neutral molecules and uranyl cation, has been studied as a possible cytotoxic agent. Cytotoxic studies performed with the human T lymphoma cell line (JURKAT) revealed that pentaphyrin 1 exhibits toxicity at microM concentrations comparable with other water soluble, porphyrin-type systems such as the pyridinium metalloporphyrins.
Král
V
V
Department of Chemistry and Biochemistry, University of Texas at Austin 78712, USA.
Brucker
E A
EA
Hemmi
G
G
Sessler
J L
JL
Králová
J
J
Bose
H
H
D000970:Antineoplastic Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D011166:Porphyrins / Q000138:chemical synthesis / Q000494:pharmacology*; D012995:Solubility; D013329:Structure-Activity Relationship; D014867:Water
D000970:Antineoplastic Agents; D011166:Porphyrins; D014867:Water