Synthesis and analytical profile of the new potent antibronchospastic agent 7-[(2,2-dimethyl)propyl]-1-methyl xanthine.
7-[(2,2-Dimethyl)propyl]-1-methyl xanthine (CAS 155006-67-0, MX2/120) is a new potent antibronchospastic agent with negligible side effects. The synthesis involves the alkylation of 3-benzyl-1-methyl xanthine with neopentyl bromide followed by removal of the benzyl protecting group. Main physico-chemical properties were determined using NMR, MS, IR, UV spectra and X-ray crystal structure. A quantitative determination of substances related to MX2/120 and of residual solvents by means of HPLC and GC, respectively, is described. MX2/120 is safely stored at room temperature for a long time.
Agostini
O
O
Istituto Farmacobiologico Malesci S.p.A., Research Laboratories, Florence, Italy.
Bonacchi
G
G
Coppini
G
G
Di Marco
G
G
Paoli
P
P
Toja
E
E
D001993:Bronchodilator Agents / Q000032:analysis* / Q000138:chemical synthesis* / Q000737:chemistry; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D002849:Chromatography, Gas; D002851:Chromatography, High Pressure Liquid; D018360:Crystallography, X-Ray; D004355:Drug Stability; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D012995:Solubility; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet; D014970:Xanthines / Q000032:analysis* / Q000138:chemical synthesis* / Q000737:chemistry
C092650:7-((2,2-dimethyl)propyl)-1-methylxanthine; D001993:Bronchodilator Agents; D014970:Xanthines