Transcription factors: structure, function, and implication in malignant growth.
Transcription factors are the principal modulators of gene expression patterns in the organism and are thus involved in processes leading to changes in developmental programmes, responses to growth and differentiation signals, and some of the alterations causing neoplastic transformation. The present overview deals with general aspects of the structure, function, and regulation of transcription factors, in relation to their physiological role and oncogenic potential.
Papavassiliou
A G
AG
European Molecular Biology Laboratory, Differentiation Programme, Heidelberg, Germany.
D000595:Amino Acid Sequence; D002454:Cell Differentiation; D002455:Cell Division; D004268:DNA-Binding Proteins / Q000737:chemistry / Q000378:metabolism; D015870:Gene Expression; D015972:Gene Expression Regulation, Neoplastic; D006801:Humans; D009369:Neoplasms / Q000378:metabolism / Q000473:pathology*; D017433:Protein Structure, Secondary; D012016:Reference Values; D014157:Transcription Factors / Q000737:chemistry / Q000378:metabolism*; D016335:Zinc Fingers
D004268:DNA-Binding Proteins; D014157:Transcription Factors