[The use of angiotensin-converting enzyme inhibitors in chronic diffuse kidney diseases].
The treatment with inhibitors of angiotensin-converting enzyme (ACE) was conducted in 57 patients with chronic diffuse renal diseases. Of them 45 patients received Capoten, 12 patients Renitek. ACE inhibitors were examined for effects on arterial pressure, proteinuria, renal and intrarenal hemodynamics. A hypotensive effect was apparent in hypertension and minimal in normotension. One month later renal bloodflow increased, glomerular filtration rate did not change. ACE inhibitors proved able to correct intrarenal hypertension: renal functional reserve returned to normal on posttreatment month 1-3 in 10 of 16 patients. Noticeable antiproteinuria effect of the drugs emerged 3 months after the treatment.
Kutyrina
I M
IM
Tareeva
I E
IE
Gerasimenko
O I
OI
Rogov
V A
VA
Miroshnichenko
N G
NG
D000293:Adolescent; D000328:Adult; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002908:Chronic Disease; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007668:Kidney / Q000187:drug effects / Q000503:physiopathology; D007674:Kidney Diseases / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D011507:Proteinuria / Q000188:drug therapy / Q000503:physiopathology; D013997:Time Factors
D000806:Angiotensin-Converting Enzyme Inhibitors
Ispol'zovanie ingibitorov angiotenzinprevrashchaiushchego fermenta pri khronicheskikh diffuznykh zabolevaniiakh pochek.