[The expression of MMPs and TIMPs in human breast cancer tissues and importance of their balance in cancer invasion and metastasis].
Tumor cells degrade extracellular matrix components (ECM) to invade surrounding tissues. Malignant tumor cells are known to produce various ECM-degrading enzymes including matrix metalloproteinases (MMPs), serine proteinases and cathepsins. Among them, MMPs may play a key role in cancer invasion and metastasis. To study the role of MMPs in the progression of human breast carcinomas, we examined production and tissue localization of MMP-1, MMP-2, MMP-3, MMP-9 and their common inhibitors, tissue inhibitors of metalloproteinases (TIMP-1 and TIMP-2). The data suggest that the imbalance between MMPs and TIMPs produced by tumor tissues may be a determinant of the progression in breast carcinoma.
Iwata
H
H
Second Department of Surgery, Nagoya City University Medical School.
Kobayashi
S
S
Iwase
H
H
Okada
Y
Y
D001943:Breast Neoplasms / Q000378:metabolism* / Q000473:pathology*; D017364:Collagenases / Q000032:analysis*; D006023:Glycoproteins / Q000032:analysis*; D006801:Humans; D061965:Matrix Metalloproteinase Inhibitors; D009362:Neoplasm Metastasis; D019714:Tissue Inhibitor of Metalloproteinases
D006023:Glycoproteins; D061965:Matrix Metalloproteinase Inhibitors; D019714:Tissue Inhibitor of Metalloproteinases; D017364:Collagenases