[Hepatic angiosarcoma: a report of a case associated with treatment with arsenic salts and a review of the literature].
Hepatic angiosarcoma is an infrequent neoplasm representing 1-3% of all the primary liver cancers. One fourth of the cases have demonstrated a relation with chemical carcinogens with the most frequent being thorium dioxide (thorotrast) and vinyl chloride. The case of an hepatic angiosarcoma which presented as an intraperitoneal hemorrhage in a patient who had undergone treatment with Neosalvarsán (dioxidiaminoarsenobenzol) 46 years beforehand is reported. The previous published reports include 6 cases of hepatic angiosarcoma related with treatment with arsenic salts and 4 cases in whom exposure was environmental.
Salgado
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Departamento de Medicina, Hospital Clinic i Provincial, Universidad de Barcelona.
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Bruguera
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Castells
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Navasa
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Rodés
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J
D001152:Arsenicals / Q000009:adverse effects*; D001153:Arsphenamine / Q000009:adverse effects / Q000031:analogs & derivatives*; D001706:Biopsy; D017809:Fatal Outcome; D006394:Hemangiosarcoma / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D006465:Hemoperitoneum / Q000175:diagnosis / Q000209:etiology; D006801:Humans; D008099:Liver / Q000473:pathology; D008113:Liver Neoplasms / Q000139:chemically induced* / Q000150:complications / Q000175:diagnosis; D008297:Male; D008875:Middle Aged; D012769:Shock / Q000175:diagnosis / Q000209:etiology; D013587:Syphilis / Q000188:drug therapy; D013997:Time Factors
D001152:Arsenicals; D001153:Arsphenamine; C073331:neoarsphenamine
Angiosarcoma hepático: presentación de un caso asociado al tratamiento con sales de arsénico y revisión de la literatura.