title: Effect of an alpha 2-adrenoceptor antagonist, midaglizole, on bronchial responsiveness to histamine in patients with mild asthma.
abstract: The purpose of this study was to investigate the effects of midaglizole (MID) and interactions of MID with beta 2-agonists on bronchial hyperresponsiveness (BHR). Thirteen patients with mild asthma were randomized with respect to whether they were taking oral beta 2-agonists, and the investigators were blinded to patients' regular drug regimens. Histamine challenge test was performed before and after oral administration of MID for 1 week (300 mg/day). There was a significant increase in PC20 values in asthmatic subjects on regular therapy with beta 2-agonists (p < 0.05), whereas asthmatics not taking beta 2-agonists showed no significant change in PC20. These results suggest that MID may participate in improved BHR in the presence of beta 2-agonists and play some role in enhancing the effects of beta 2-agonists.
authors.affiliation: First Department of Internal Medicine, Gunma University School of Medicine, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Sakai
authors.forename: K
authors.initials: K
authors.lastname: Dobashi
authors.forename: T
authors.initials: T
authors.lastname: Nakazawa
mesh_terms: D000284:Administration, Oral; D000317:Adrenergic alpha-Antagonists / Q000008:administration & dosage / Q000494:pharmacology*; D000318:Adrenergic beta-Agonists / Q000627:therapeutic use; D000328:Adult; D001249:Asthma / Q000188:drug therapy / Q000503:physiopathology*; D016535:Bronchial Hyperreactivity / Q000503:physiopathology*; D001985:Bronchial Provocation Tests; D004347:Drug Interactions; D005260:Female; D006632:Histamine; D006801:Humans; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D008297:Male
chemical_list: D000317:Adrenergic alpha-Antagonists; D000318:Adrenergic beta-Agonists; D007093:Imidazoles; C032368:midaglizole; D006632:Histamine