Colchicine induces enhanced intestinal permeability in the rat.
Intestinal permeability was determined in rats receiving colchicine 0.5 +/- 0.15 mg day-1 in drinking water (30 mg L-1) for periods up to 23 days. The lactulose/mannitol method was used to determine whole gut permeability before and on days 2, 4, 8, 18 and 23 of colchicine administration. The 8-h urinary lactulose excretion following the test meal increased significantly in rats receiving colchicine, compared with the pretreatment value. Increased lactulose permeability was present after 2 days and remained stable throughout the experimental period. Mannitol urinary excretion was not changed. Colchicine increases intestinal tight junction permeability by an as yet undetermined mechanism.
Fradkin
A
A
Paediatric Gastrointestinal Unit, Chaim Sheba Medical Center, Tel Hashomer, Israel.
Yahav
J
J
Diver-Haber
A
A
Zemer
D
D
Jonas
A
A
D000818:Animals; D003078:Colchicine / Q000494:pharmacology*; D004326:Drinking; D007408:Intestinal Absorption / Q000187:drug effects; D007422:Intestines / Q000187:drug effects*; D007792:Lactulose / Q000378:metabolism; D008353:Mannitol / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
D008353:Mannitol; D007792:Lactulose; D003078:Colchicine