Excessive bone resorption in human plasmacytomas: direct induction by tumour cells in vivo.
We studied the bone resorption (BR) in 82 patients with overt plasmacytomas (PCT) by histomorphometry. All the solitary PCT and 90% of overt PCT in complete remission lacked excessive BR. In contrast, 73% of the 68 patients with active overt PCT had an excessive BR. This excessive BR was highly related to the presence of tumour cells within the bone sample. Indeed, 92% of patients with active PCT and tumour cells within the biopsy had an excessive BR. On the other hand, 70% of patients with active PCT but lacking tumour cells within the biopsy had normal BR.
Bataille
R
R
Laboratoire d'Hématologie, Institut de Biologie, Nantes, France.
Chappard
D
D
Basle
M
M
D000368:Aged; D001706:Biopsy; D001862:Bone Resorption / Q000209:etiology / Q000473:pathology*; D001842:Bone and Bones / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D009101:Multiple Myeloma / Q000473:pathology; D010954:Plasmacytoma / Q000150:complications / Q000473:pathology*; D014407:Tumor Cells, Cultured