The cecum does not participate in the stimulation of intestinal calcium absorption by calcitriol.
Intestinal Ca absorption from the diet consumed during one night was measured in male rats fed a normal (0.5%) Ca, low fiber (3% cellulose) diet by determining the decrease in 47Ca/47Sc ratio between diet and feces. One-half of the rats had been cecectomized 9 weeks previously at 14 weeks of age. Calcitriol injections, given intraperitoneally the morning of the experiment, stimulated fractional intestinal Ca absorption 2.5-fold in intact rats (16.9 +/- 2.0% to 42.2 +/- 1.8%) and 2.3-fold in cecectomized rats (20.1 +/- 1.4% to 46.8 +/- 1.2%). Similar results were obtained when the data were calculated in terms of total Ca absorption expressed as mg/day. Thus, although the cecum can absorb Ca when diets contain large amounts of digestible fiber, cecectomy does not influence the stimulation of intestinal Ca absorption induced by calcitriol in vitamin D-replete rats fed a low fiber diet.
Brommage
R
R
Nestlé Research Centre, Vers-chez-les-Blanc, Lausanne, Switzerland.
Binacua
C
C
Carrié
A L
AL
D000818:Animals; D002117:Calcitriol / Q000378:metabolism / Q000494:pharmacology*; D002136:Calcium, Dietary / Q000008:administration & dosage / Q000378:metabolism*; D002432:Cecum / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000378:metabolism*; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D002136:Calcium, Dietary; D002117:Calcitriol