title: Parental origin of the extra haploid chromosome set in triploidies diagnosed prenatally.
abstract: The parental origin of the additional chromosome complement in a total of 17 cases of triploidy was determined mainly using highly polymorphic microsatellites. Maternal origin of the triploidy was demonstrated in most cases. To the best of our knowledge, this is the first systematic evaluation of the parental origin of chromosome sets in fetuses who survived until a cytogenetic diagnosis was established. In contrast to previous investigations this study documented a predominance of maternal origin of the extra haploid set mainly due to longer survival time for digynic triploidies. The concept of 2 distinct fetal phenotypes in triploidy is clearly supported by this study.
authors.affiliation: Institute for Human Genetics, University of Münster, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Miny
authors.forename: B
authors.initials: B
authors.lastname: Koppers
authors.forename: B
authors.initials: B
authors.lastname: Dworniczak
authors.forename: N
authors.initials: N
authors.lastname: Bogdanova
authors.forename: W
authors.initials: W
authors.lastname: Holzgreve
authors.forename: S
authors.initials: S
authors.lastname: Tercanli
authors.forename: S
authors.initials: S
authors.lastname: Basaran
authors.forename: H
authors.initials: H
authors.lastname: Rehder
authors.forename: R
authors.initials: R
authors.lastname: Exeler
authors.forename: J
authors.initials: J
authors.lastname: Horst
mesh_terms: D000328:Adult; D004276:DNA, Satellite / Q000235:genetics; D005260:Female; D030342:Genetic Diseases, Inborn / Q000175:diagnosis / Q000196:embryology*; D005819:Genetic Markers; D005865:Gestational Age; D006238:Haploidy; D006801:Humans; D007621:Karyotyping; D008297:Male; D008423:Maternal Age; D011003:Ploidies; D016133:Polymerase Chain Reaction; D011110:Polymorphism, Genetic; D011123:Polyploidy; D011247:Pregnancy; D011296:Prenatal Diagnosis
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers