[Effect of PCBs on insulin sensitivity in rats].
Insulin sensitivity was assessed by euglycemic insulin clamp method in the rats given Kanechlor (KC)-400 for 1 to 12 weeks. As a result, insulin sensitivity was depressed increasingly with period of administration of KC-400. Increases in total cholesterol, HDL-C, triglyceride, lipid peroxide and T3 in blood plasma were also observed in the experimental rats. Voluntary daily activity of rats given KC-400, especially in a later half of night-time, had been depressed since approximately 9 weeks after start of the experiment. It was concluded that depression of insulin sensitivity might be related to not only disturbance of glucose and lipid metabolism, but reduced daily activity in conjunction with disturbed thyroid function.
Nishizumi
M
M
Department of Community Health Science, Saga Medical School.
Higaki
Y
Y
D000818:Animals; D005947:Glucose / Q000378:metabolism; D007037:Hypothyroidism / Q000139:chemically induced; D007333:Insulin Resistance; D008055:Lipids / Q000097:blood*; D008297:Male; D009043:Motor Activity / Q000187:drug effects; D011078:Polychlorinated Biphenyls / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D014284:Triiodothyronine / Q000097:blood
D008055:Lipids; D014284:Triiodothyronine; C039772:KC 400; D011078:Polychlorinated Biphenyls; D005947:Glucose