Magnetic resonance spectroscopy in neonates.
Magnetic resonance spectroscopy allows noninvasive assessment of cerebral metabolism in newborn infants. 31P magnetic resonance spectroscopy has demonstrated that birth asphyxia leads to delayed impairment of cerebral energy metabolism and 1H magnetic resonance spectroscopy has shown lactate accumulation and a later decline in N-acetyl aspartate concentration. 13C magnetic resonance spectroscopy may help explain these observations.
Azzopardi
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Department of Paediatrics and Neonatal Medicine, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.
Edwards
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D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000378:metabolism; D001238:Asphyxia Neonatorum / Q000150:complications / Q000503:physiopathology; D001921:Brain / Q000503:physiopathology*; D004734:Energy Metabolism / Q000502:physiology*; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D007773:Lactates / Q000378:metabolism; D019344:Lactic Acid; D009682:Magnetic Resonance Spectroscopy / Q000379:methods*; D012016:Reference Values; D013036:Spasms, Infantile / Q000209:etiology / Q000503:physiopathology*
D007773:Lactates; D001224:Aspartic Acid; D019344:Lactic Acid; C000179:N-acetylaspartate