title: Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22.
abstract: We have performed linkage analysis in 186 multiplex families to search for genes that predispose to schizophrenia. Under a model with partially dominant inheritance, moderately broad disease definition and assuming locus homogeneity, a lod score of 3.2 was obtained for D6S260 on chromosome 6p23. A multipoint lod score of 3.9 (P = 2.3 x 10(-5)) was achieved when the F13A1 and D6S260 loci were analysed, allowing for locus heterogeneity. Adjusted for testing of multiple models, the multipoint lod score of 3.9 under heterogeneity has a genome wide significance of between 5-8%. The nonparametric affected pedigree member test provided results (P = 3 x 10(-4)) also supporting this finding. Our findings provide supportive evidence for a susceptibility locus for schizophrenia on distal chromosome 6p, and support a model of locus heterogeneity.
authors.affiliation: Molecular Epidemiology and Disease Indicators Branch, NIDR, Bethesda, Maryland 20892, USA.
authors.forename: S
authors.initials: S
authors.lastname: Wang
authors.forename: C E
authors.initials: CE
authors.lastname: Sun
authors.forename: C A
authors.initials: CA
authors.lastname: Walczak
authors.forename: J S
authors.initials: JS
authors.lastname: Ziegle
authors.forename: B R
authors.initials: BR
authors.lastname: Kipps
authors.forename: L R
authors.initials: LR
authors.lastname: Goldin
authors.forename: S R
authors.initials: SR
authors.lastname: Diehl
mesh_terms: D002896:Chromosomes, Human, Pair 6; D004276:DNA, Satellite; D005260:Female; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D012559:Schizophrenia / Q000235:genetics*
chemical_list: D004276:DNA, Satellite; D005819:Genetic Markers