title: Fetal tissue dosages of retinoids. Experimental study concerning a case of isotretinoin (Roaccutan) administration and pregnancy.
abstract: The authors report the case of a women who took retinoids (Roaccutan, isotretinoin) during the first trimester of pregnancy, and a therapeutic abortion was carried out. The interest in this case report lies in the determination of the concentration of isotretinoin and its metabolites (4-oxo-isotretinoin, and tretinoin) in fetal tissues, using high performance liquid chromatography. The findings show the significant transplacental crossing of isotretinoin, an accumulation of 4-oxo-isotretinoin in the liver, and a low concentration of retinoids in the brain of this 4-month-old fetus. The authors emphasize that contraception must be used during retinoid treatment, and 4 weeks after retinoids have been stopped.
authors.affiliation: Department of Obstetrics and Gynecology, A. Béclère Hospital, Clamart, France.
authors.forename: J L
authors.initials: JL
authors.lastname: Benifla
authors.forename: Y
authors.initials: Y
authors.lastname: Ville
authors.forename: M C
authors.initials: MC
authors.lastname: Imbert
authors.forename: R
authors.initials: R
authors.lastname: Frydman
authors.forename: A
authors.initials: A
authors.lastname: Thomas
authors.forename: J C
authors.initials: JC
authors.lastname: Pons
mesh_terms: D000032:Abortion, Therapeutic; D000152:Acne Vulgaris / Q000188:drug therapy; D001921:Brain / Q000378:metabolism; D005260:Female; D005333:Fetus / Q000378:metabolism*; D006801:Humans; D015474:Isotretinoin / Q000009:adverse effects / Q000493:pharmacokinetics* / Q000627:therapeutic use; D008099:Liver / Q000378:metabolism; D008431:Maternal-Fetal Exchange; D011247:Pregnancy
chemical_list: D015474:Isotretinoin