Lipid biosynthetic genes and a ribosomal protein gene are cotranscribed.
By using insertional mutagenesis we demonstrated that the rpmF gene encoding ribosomal protein L32, the plsX gene encoding a protein involved in membrane lipid synthesis and several fatty acid biosynthetic genes (fabH, fabD and fabG) are cotranscribed. Organization of these genes into an operon may play a role in the coordinate regulation of the synthesis of ribosomes and the cell membranes.
Podkovyrov
S
S
Department of Biochemistry and Anaerobic Microbiology, Virginia Polytechnic Institute and State University, Blacksburg 24061-0308, USA.
Larson
T J
TJ
D064431:3-Oxoacyl-(Acyl-Carrier-Protein) Reductase; D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase / Q000235:genetics; D051080:Acyl-Carrier Protein S-Malonyltransferase; D000217:Acyltransferases / Q000235:genetics; D000429:Alcohol Oxidoreductases / Q000235:genetics; D001426:Bacterial Proteins / Q000235:genetics*; D004926:Escherichia coli / Q000235:genetics / Q000378:metabolism; D029968:Escherichia coli Proteins; D054889:Fatty Acid Synthase, Type II; D008563:Membrane Lipids / Q000096:biosynthesis*; D016254:Mutagenesis, Insertional; D012269:Ribosomal Proteins / Q000235:genetics*; D014158:Transcription, Genetic
D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; D008563:Membrane Lipids; D012269:Ribosomal Proteins; C490246:plsX protein, E coli; C088150:plsX protein, bacteria; C041806:ribosomal protein L32; D000429:Alcohol Oxidoreductases; D064431:3-Oxoacyl-(Acyl-Carrier-Protein) Reductase; D000217:Acyltransferases; C077402:3-ketoacyl-acyl carrier protein synthase III; D051080:Acyl-Carrier Protein S-Malonyltransferase; C494968:fabD protein, E coli; D015099:3-Oxoacyl-(Acyl-Carrier-Protein) Synthase; D054889:Fatty Acid Synthase, Type II