title: [The effect of mexidol on the rat periodontium during hypokinesia].
abstract: During 30-days-long hypokinesia changes in calcium-phosphoric metabolism, glycoprotein state, acid and alkaline phosphatase activity in bone tissue of the low jaw of rats proceed in some stages, that determines the nature of mexidol (3-oxipyridine derivative) effects. The remedy demonstrated the most expressed protective effect on parodontal tissues on the 15th day of animals' mobility limitation. The data obtained show that mexidol effecting hypokinesia develop in some stages and depend on the initial state of the organism. They also reflect indirectly the significance of the antioxidant status of the organism in mineralization of the parodontal bone tissue.
authors.forename: E G
authors.initials: EG
authors.lastname: Kovalenko
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000494:pharmacology* / Q000627:therapeutic use; D002908:Chronic Disease; D004353:Drug Evaluation, Preclinical; D018476:Hypokinesia / Q000188:drug therapy / Q000378:metabolism*; D008297:Male; D008334:Mandible / Q000187:drug effects / Q000378:metabolism; D010012:Osteogenesis / Q000187:drug effects; D010519:Periodontium / Q000187:drug effects* / Q000378:metabolism; D010847:Picolines / Q000494:pharmacology* / Q000627:therapeutic use; D051381:Rats; D017208:Rats, Wistar; D013997:Time Factors
chemical_list: D000975:Antioxidants; D010847:Picolines; C070020:emoxypine succinate
vernacular_title: Vliianie meksidola na parodont krys pri gipokinezii.