High tin intake reduces copper status in rats through inhibition of copper absorption.
The mechanism underlying the reduced Cu status in rats fed on a high-Sn diet was investigated. Male rats aged 4 weeks were fed ad lib. on purified diets containing either 1 or 100 mg Sn/kg and demineralized water for a period of 4 weeks. The high-Sn diet had no effect on feed intake, body-weight gain or weight of liver and kidney but significantly reduced Cu concentrations in plasma, liver and kidney. Biliary Cu excretion was decreased significantly in rats fed on the high-Sn diet. Apparent Cu absorption (Cu intake-faecal Cu) was not affected by the high-Sn diet, but the estimate of true Cu absorption (Cu intake-(faecal Cu-biliary Cu)) was significantly reduced. We conclude that high Sn intake reduces Cu status in rats through inhibition of Cu absorption. The decreased biliary Cu excretion observed on the high-Sn diet is a result of the reduced Cu absorption.
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Department of Human Nutrition, Wageningen Agricultural University, The Netherlands.
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D000818:Animals; D001646:Bile / Q000378:metabolism; D003300:Copper / Q000097:blood / Q000378:metabolism*; D005243:Feces / Q000737:chemistry; D007408:Intestinal Absorption; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009752:Nutritional Status; D051381:Rats; D017208:Rats, Wistar; D014001:Tin / Q000008:administration & dosage*
D014001:Tin; D003300:Copper