title: [Hemophagocytic syndrome in children infected by HIV. Apropos of 3 cases].
abstract: BACKGROUND
  The hemophagocytic syndrome has previously been reported in different infectious diseases (EBV, CMV, tuberculosis...) but rarely in adults with AIDS and never in children suffering from AIDS.
  
  
  METHODS
  A hemophagocytic syndrome was recognized during the follow-up of 3 children with AIDS. The first, a 9-year-old girl developed an acute EBV coinfection and was treated with shots of corticosteroids and vepesid but died shortly afterwards. The second patient, a 3-year-old girl was infected with Aspergillus fumigatus for which she was given amphotericin B with a rapid improvement. The third patient, an 8-year-old boy had multi-resistant Streptococcus pneumoniae otitis and pneumonitis; his condition improved rapidly with adapted antibiotherapy.
  
  
  CONCLUSIONS
  The HIV-hemophagocytic syndrome is not exceptional in HIV infection because of the association of immunodeficiency and resulting superinfections. Its diagnosis and treatment should be etiologic. Severe cases without etiology could benefit from chemotherapy.
  
  
  CONCLUSIONS
  Management and outcome of this potentially lethal syndrome might depend on the identification of a curable infectious cause.
authors.affiliation: Département de pédiatrie Edmond-Lesné, hôpital d'enfants Armand-Trousseau, Paris, France.
authors.forename: J H
authors.initials: JH
authors.lastname: Dalle
authors.forename: C
authors.initials: C
authors.lastname: Dollfus
authors.forename: G
authors.initials: G
authors.lastname: Leverger
authors.forename: J
authors.initials: J
authors.lastname: Landman-Parker
authors.forename: M D
authors.initials: MD
authors.lastname: Tabone
authors.forename: M
authors.initials: M
authors.lastname: Adam
authors.forename: C
authors.initials: C
authors.lastname: Courpotin
authors.forename: G
authors.initials: G
authors.lastname: Lasfargues
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000188:drug therapy / Q000209:etiology*; D002648:Child; D002675:Child, Preschool; D005260:Female; D015658:HIV Infections / Q000150:complications* / Q000382:microbiology; D015616:Histiocytosis, Non-Langerhans-Cell / Q000188:drug therapy / Q000209:etiology*; D006801:Humans; D008297:Male
vernacular_title: Syndrome d'activation macrophagique chez l'enfant infecté par le VIH. A propos de trois cas.