title: Cytokine profile in acute myelofibrosis associated with aggressive large granular lymphocyte leukemia.
abstract: We report a patient with acute large granular lymphocyte (LGL) leukemia, presenting as acute myelofibrosis (AMF). The leukemic cells were immature T-cells (CD5+, CD7+, CD16-, CD56-, CD57-, and CD41-), had monosomy 7, and secreted large amounts of Transforming Growth Factor-beta 1(TGF-beta 1). The serum levels of interleukins (IL)-2, -2R, -6 and -8 were elevated, while the IL-1 beta, IL-4, and tumor necrosis factor-alpha were normal.
authors.affiliation: Division of Hematopathology, Vancouver General Hospital, BC, Canada.
authors.forename: B I
authors.initials: BI
authors.lastname: Dalal
authors.forename: P A
authors.initials: PA
authors.lastname: Keown
authors.forename: F
authors.initials: F
authors.lastname: Paraskevas
authors.forename: G
authors.initials: G
authors.lastname: Williams
authors.forename: J B
authors.initials: JB
authors.lastname: Johnston
mesh_terms: D000208:Acute Disease; D001853:Bone Marrow / Q000473:pathology; D016207:Cytokines / Q000097:blood*; D005260:Female; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications / Q000378:metabolism* / Q000473:pathology; D008875:Middle Aged; D055728:Primary Myelofibrosis / Q000150:complications / Q000378:metabolism* / Q000473:pathology
chemical_list: D016207:Cytokines