title: Individual susceptibility and prevention of occupational diseases: scientific and ethical issues.
abstract: Genetic testing of employees is controversial; objections have been raised with regard to privacy, right to work, and the relevance of the tests. A study is being conducted on "the ethical, social, and scientific problems related to the application of genetic screening and genetic monitoring for employees in the context of a European approach to health and safety at work." A conceptual model is proposed of the complex interactions between exposure, acquired and inherited susceptibility, and risk for disease. The validity of tests for determining genotype and phenotype and their relevance for disease must be evaluated critically to provide an objective basis for ethical discussions. The acceptability of such tests is related to a number of issues, which are identified and discussed.
authors.affiliation: European Trade Union Technical Bureau for Health and Safety, Brussels, Belgium.
authors.forename: K
authors.initials: K
authors.lastname: Van Damme
authors.forename: L
authors.initials: L
authors.lastname: Casteleyn
authors.forename: E
authors.initials: E
authors.lastname: Heseltine
authors.forename: A
authors.initials: A
authors.lastname: Huici
authors.forename: M
authors.initials: M
authors.lastname: Sorsa
authors.forename: N
authors.initials: N
authors.lastname: van Larebeke
authors.forename: P
authors.initials: P
authors.lastname: Vineis
mesh_terms: D004198:Disease Susceptibility; D004989:Ethics; D005820:Genetic Testing / Q000379:methods; D006801:Humans; D008403:Mass Screening / Q000379:methods; D009784:Occupational Diseases / Q000453:epidemiology / Q000235:genetics / Q000517:prevention & control; D009787:Occupational Medicine / Q000592:standards*; D012680:Sensitivity and Specificity