Synthesis and antiarrhythmic properties of basic amide derivatives of imidazolidine-2,4-dione and pyrrolidine-2,5-dione II.
Basic amide derivatives of imidazolidine-2,4-dione and pyrrolidine-2,5-dione were synthesized as potential antiarrhythmic agents. Some of them have shown antiarrhythmic activity in the chloroform, barium chloride or adrenaline induced arrhythmia.
Kieć-Kononowicz
K
K
Zakład Technologii Chemicznej, Srodkow Leczniczych Collegium Medicum, Uniwersytet Jagiellonski, Kraków, Polska.
Byrtus
H
H
Zejc
A
A
Filipek
B
B
Chevallet
P
P
D000577:Amides / Q000138:chemical synthesis / Q000494:pharmacology*; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000737:chemistry / Q000494:pharmacology*; D001145:Arrhythmias, Cardiac / Q000139:chemically induced / Q000188:drug therapy; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D008297:Male; D051379:Mice; D015394:Molecular Structure; D011759:Pyrrolidines / Q000138:chemical synthesis / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar
D000577:Amides; D000889:Anti-Arrhythmia Agents; D007093:Imidazoles; D011759:Pyrrolidines