title: Diffuse bilateral lung uptake of TI-201 chloride in CMV pneumonitis. Case presentation with histopathologic correlation.
abstract: Diffuse intense lung uptake of TI-201 chloride without abnormal Ga-67 citrate in a case of cytomegalovirus pneumonitis in a patient with AIDS is presented. An autopsy performed within 4 days of imaging revealed no pulmonary pathology other than diffuse cytomegalovirus infection with abundant histiocytes and inclusion bodies and pulmonary congestive heart failure. Among the various mechanisms of TI-201 accumulation, active transport through Na-K ATPase appears to be predominant in this case, as suggested by innumerable histiocytes. It is the authors' experience that positive TI-201 uptake without abnormal Ga-67 accumulation is highly specific for pulmonary Kaposi sarcoma. The presence of such discrepancy between TI-201 and Ga-67 uptake in AIDS patients decreases the specificity of a TI-201 positive/Ga-67 negative lesion for pulmonary Kaposi sarcoma, especially with the rising incidence of both cytomegalovirus and Kaposi sarcoma in AIDS patients.
authors.affiliation: Department of Radiology, St. Vincent's Hospital and Medical Center of New York, NY 10011, USA.
authors.forename: R
authors.initials: R
authors.lastname: Bag
authors.forename: G R
authors.initials: GR
authors.lastname: Tambouret
authors.forename: J
authors.initials: J
authors.lastname: Kempf
authors.forename: N
authors.initials: N
authors.lastname: Habbab
authors.forename: A
authors.initials: A
authors.lastname: Sadik
authors.forename: L
authors.initials: L
authors.lastname: Difabrizio
authors.forename: H M
authors.initials: HM
authors.lastname: Abdel-Dayem
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000150:complications / Q000000981:diagnostic imaging; D000328:Adult; D003586:Cytomegalovirus Infections / Q000150:complications / Q000000981:diagnostic imaging*; D005260:Female; D005710:Gallium Radioisotopes; D006801:Humans; D008168:Lung / Q000000981:diagnostic imaging*; D011024:Pneumonia, Viral / Q000150:complications / Q000000981:diagnostic imaging*; D013794:Thallium Radioisotopes; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D005710:Gallium Radioisotopes; D013794:Thallium Radioisotopes