Antibody humanization predicted by computer graphic analysis.
Humanized antibodies continue to be evaluated in clinical trials, and each trial will yield valuable information for the design of the next generation of humanized antibodies. More attention will be given to the use of antibody fragments and the selection of human antibody specificities from phage libraries for human antibody therapeutics. Computer graphic analysis and molecular modeling of antibody structures will continue to be invaluable for predicting structural modifications for humanization of antibodies and for extracting structural information from antigen binding sites that can ultimately lead to small molecule therapeutics.
Ramnarayan
K
K
ImmunoPharmaceutics, Inc., San Diego, CA, USA.
Skaletsky
E
E
D000818:Animals; D000906:Antibodies / Q000737:chemistry*; D003196:Computer Graphics; D006801:Humans; D007135:Immunoglobulin Variable Region / Q000737:chemistry; D008958:Models, Molecular; D011994:Recombinant Proteins / Q000737:chemistry
D000906:Antibodies; D007135:Immunoglobulin Variable Region; D011994:Recombinant Proteins