title: Reduced temporal lobe glucose metabolism in aging.
abstract: The results of a positron emission tomography study of regional cerebral metabolic rates of glucose are reported for 8 healthy old subjects (mean age, 66 yr; standard deviation [SD], 5) and 9 young subjects (mean age, 27 yr; SD, 4.6) using a high-resolution positron emission tomograph and the glucose metabolic tracer 18F-fluorodeoxyglucose. Older subjects showed significantly lower cerebral metabolic rates than did the young subjects, in anterior, middle, and posterior temporal neocortex and in mesial temporal cortex, with the largest differences occurring in anterior temporal cortex (temporal pole). The current findings may reflect either decreases in regional cerebral metabolic rates for glucose that occur with normal aging, or early indications of cognitive dysfunction that is associated with age-related disorders.
authors.affiliation: Center for Functional Imaging, Lawrence Berkeley Laboratory University of California, Berkeley 94720, USA.
authors.forename: J L
authors.initials: JL
authors.lastname: Eberling
authors.forename: T E
authors.initials: TE
authors.lastname: Nordahl
authors.forename: N
authors.initials: N
authors.lastname: Kusubov
authors.forename: B R
authors.initials: BR
authors.lastname: Reed
authors.forename: T F
authors.initials: TF
authors.lastname: Budinger
authors.forename: W J
authors.initials: WJ
authors.lastname: Jagust
mesh_terms: D000328:Adult; D000368:Aged; D000375:Aging / Q000378:metabolism*; D001786:Blood Glucose / Q000032:analysis; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D013702:Temporal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism*; D014055:Tomography, Emission-Computed
chemical_list: D001786:Blood Glucose; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose