Different actions of some relaxant agents acting via the cAMP system in rat uterus.
The influence of propranolol, isoprenaline, papaverine and caffeine on basal tone and contractile responses to spasmogens (oxytocin, KCl) was investigated in the presence and the absence of external calcium in estrogen-treated rat uterus. Isoprenaline, papaverine and caffeine relaxed precontracted uterus and caffeine also decreased the basal tone of uterine muscle in calcium-containing or calcium-free solution. Propranolol had a dual activity in calcium-free medium: lower concentrations contracted the sustained contraction elicited by oxytocin, whereas the highest concentration partially relaxed it. In calcium-containing solution the highest dose of propranolol partially inhibited KCl-induced contractions.
Chulia
S
S
Department of Pharmacology, Faculty of Pharmacy, University of Valencia, Spain.
Noguera
M A
MA
Fayos
G
G
Anselmi
E
E
Ivorra
M D
MD
D'Ocon
M P
MP
D000818:Animals; D002110:Caffeine / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology; D000242:Cyclic AMP / Q000378:metabolism*; D004305:Dose-Response Relationship, Drug; D004967:Estrogens / Q000494:pharmacology; D005260:Female; D066298:In Vitro Techniques; D007545:Isoproterenol / Q000494:pharmacology*; D010121:Oxytocin / Q000494:pharmacology; D010208:Papaverine / Q000494:pharmacology*; D011189:Potassium Chloride / Q000494:pharmacology; D011433:Propranolol / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012044:Regression Analysis; D014590:Uterine Contraction / Q000187:drug effects* / Q000502:physiology
D004967:Estrogens; D002110:Caffeine; D010121:Oxytocin; D011189:Potassium Chloride; D011433:Propranolol; D010208:Papaverine; D000242:Cyclic AMP; D007545:Isoproterenol; D002118:Calcium