title: Characteristics of the venous hemodynamics of the leg under simulated weightlessness: effects of physical exercise as countermeasure.
abstract: In order to test the hypothesis that increases in calf venous distensibility in microgravity are partly due to the changes affecting the surrounding skeletal muscles (muscular atrophy), 12 healthy volunteers were exposed for 28 d to microgravity simulated by -6 degrees head-down bed rest. Half these subjects were exposed to countermeasures during bed rest: a) repeated LBNP (Lower Body Negative Pressure) sequences starting on the 15th d with one 15 min sequence at -35 mb, every other day from the 15th until the 21st d, and then every day until the end of bed rest; b) physical training including isotonic type exercise and isometric or isokinetic work by all muscle mass of upper and lower limbs (from the 8th until the 28th d). The other six subjects forming the control group were not subjected to any countermeasure. Calf venous hemodynamics were determined by mercury strain gauge plethysmography with venous occlusion. Distensibility (delta Vmax) and venous emptying (venous outflow at the 6th s of emptying: VO6, half-emptying time: T1/2, maximum venous outflow (MVO) could also be measured. Nuclear magnetic resonance (NMR) was used to study changes in volume of calf muscles. Plethysmographic measurements made for each subject prior to, during (once a week), and after bed rest show a parallel increase in calf venous distensibility in both groups of subjects until the 20th d of bed rest. Filling and emptying times then tended to stabilize in the group treated with countermeasures (group CM) whereas high venous distensibility was observed until the end of bed rest and 5 d thereafter in the control group (group C).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Centre d'Etudes et de Recherches de Médecine Aérospatiale, Paris, France.
authors.forename: F
authors.initials: F
authors.lastname: Louisy
authors.forename: P
authors.initials: P
authors.lastname: Berry
authors.forename: J F
authors.initials: JF
authors.lastname: Marini
authors.forename: A
authors.initials: A
authors.lastname: Güell
authors.forename: C Y
authors.initials: CY
authors.lastname: Guezennec
mesh_terms: D000328:Adult; D006439:Hemodynamics; D006801:Humans; D007866:Leg / Q000098:blood supply*; D008150:Lower Body Negative Pressure; D009682:Magnetic Resonance Spectroscopy; D009119:Muscle Contraction; D018482:Muscle, Skeletal / Q000033:anatomy & histology / Q000502:physiology; D005082:Physical Exertion; D010991:Plethysmography; D012146:Rest; D014680:Veins / Q000502:physiology; D014893:Weightlessness