title: Correlation of dynamic responses in the ON bipolar neuron and the b-wave of the electroretinogram.
abstract: 2-Amino-4-phosphonobutyrate (APB) is known to selectively suppress the light response of ON bipolar cells in the vertebrate retina, and reduce the b-wave of the electroretinogram (ERG) as a consequence. Using slow drug application, the progressive effect of APB was used to compare the relative response amplitudes of the b-wave and the ON bipolar cell. Simultaneous ERG recordings and ON bipolar intracellular recordings were performed in the amphibian retina. The results indicate that there is a strong positive correlation between these two waveforms. This supports the possibility that the b-wave of the ERG is the direct result of ON bipolar cell activity.
authors.affiliation: Department of Biophysical Sciences, SUNY School of Medicine, Buffalo 14214, USA.
authors.forename: N
authors.initials: N
authors.lastname: Tian
authors.forename: M M
authors.initials: MM
authors.lastname: Slaughter
mesh_terms: D000557:Ambystoma; D000613:Aminobutyrates / Q000494:pharmacology; D000818:Animals; D046508:Culture Techniques; D004596:Electroretinography / Q000187:drug effects; D009475:Neurons, Afferent / Q000187:drug effects / Q000502:physiology*; D010775:Photic Stimulation; D012160:Retina / Q000187:drug effects / Q000502:physiology*
chemical_list: D000613:Aminobutyrates; C012729:2-amino-4-phosphonobutyric acid