Functional liver imaging with asialoglycoprotein receptors and serum hyaluronate in a patient with amyloidosis.
A 47-year-old man with primary amyloidosis was admitted with abdominal pain. A new radionuclide liver imaging technique using Technetium-99m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin, was performed and the serum hyaluronate concentration was measured. Although ordinary laboratory tests revealed only slight abnormalities, the uptake of the radiolabelled ligand for hepatocyte asialo-glycoprotein receptors was decreased, and marked hepatomegaly was revealed. Furthermore, the serum hyaluronate level was elevated. Histological examination of a hepatic needle biopsy specimen revealed a marked deposition of amyloid in the hepatic perisinusoidal spaces. These results indicate that this new radionuclide liver imaging technique (using Technetium-99m diethylenetriamine-pentaacetic acid-galactosyl human serum albumin) and the measurement of serum hyaluronate may be useful supplementary tools for identifying amyloid deposition in the hepatic perisinusoidal spaces in patients with amyloidosis.
Hashimoto
O
O
Social Insurance Kurume Daiichi Hospital, Japan.
Harada
M
M
Sata
M
M
Imamura
K
K
Matsukuma
N
N
Fukushima
H
H
Itano
S
S
Ohishi
M
M
Ueno
T
T
Iemura
A
A
D000686:Amyloidosis / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D001212:Asialoglycoproteins / Q000378:metabolism; D006801:Humans; D006820:Hyaluronic Acid / Q000097:blood; D008107:Liver Diseases / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000378:metabolism; D008111:Liver Function Tests; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D011877:Radionuclide Imaging; D013668:Technetium Tc 99m Aggregated Albumin; D016284:Technetium Tc 99m Pentetate
D001212:Asialoglycoproteins; D013668:Technetium Tc 99m Aggregated Albumin; C070561:technetium Tc 99m DTPA-galactosyl-human serum albumin; D006820:Hyaluronic Acid; D016284:Technetium Tc 99m Pentetate