title: Plasmid rolling circle replication and its control.
abstract: This review summarises current information on rolling circle replicating plasmids originally isolated from Gram-positive bacteria with a low guanine and cytosine content in their DNA. It focuses on the peculiar biological features of these small, high copy number plasmids that replicate via an asymmetric RC mechanism. The regulation of plasmid copy number is also discussed.
authors.affiliation: Centro de Investigaciones Biológicas, CSIC, Madrid, Spain.
authors.forename: M
authors.initials: M
authors.lastname: Espinosa
authors.forename: G
authors.initials: G
authors.lastname: del Solar
authors.forename: F
authors.initials: F
authors.lastname: Rojo
authors.forename: J C
authors.initials: JC
authors.lastname: Alonso
mesh_terms: D001426:Bacterial Proteins / Q000502:physiology; D004265:DNA Helicases; D004261:DNA Replication; D004268:DNA-Binding Proteins; D010448:Peptide Initiation Factors / Q000502:physiology; D010957:Plasmids; D015534:Trans-Activators / Q000502:physiology
chemical_list: D001426:Bacterial Proteins; D004268:DNA-Binding Proteins; D010448:Peptide Initiation Factors; D015534:Trans-Activators; C045264:replication initiator protein; D004265:DNA Helicases