title: Increase of stability in external fracture fixation by hydroxyapatite-coated bone screws.
abstract: A major problem in fracture treatment by external fixation is screw loosening, which often results in reduced stability and can lead to prolonged treatment. A load-carrying experiment was conducted to determine whether coating implants with bioactive hydroxyapatite (HA) increases screw stability. Twelve HA-coated ASIF screws with 3 different macroporosities were inserted in 12 sheep that had already been fitted with a 6-pin external fixator for the treatment of a tibial osteotomy. The same number of uncoated polished steel screws served as controls. Although initial stability was not different for HA-coated screws, average removal torque after a 9-week implantation period increased with increasing macroporosity of the HA coating (p < .002). Instability of some screws was accompanied by histologic findings of cartilagenous tissue and proliferation of periosteal callus. Near the threads in the tibial cortex and in the shaft area of the screw were seen large numbers of HA particles that had been sheared off during implantation as well as during screw removal because of high contact forces between the HA coating and bone. Particulate debris of HA particles as well as the release of small bone fragments during explanation is likely to be unavoidable since HA adherence to bone is greater than adherence to steel after several weeks of implantation.
authors.affiliation: Abteilung Unfallchirurgische Forschung und Biomechanik, University of Ulm, Germany.
authors.forename: P
authors.initials: P
authors.lastname: Augat
authors.forename: L
authors.initials: L
authors.lastname: Claes
authors.forename: K F
authors.initials: KF
authors.lastname: Hanselmann
authors.forename: G
authors.initials: G
authors.lastname: Suger
authors.forename: W
authors.initials: W
authors.lastname: Fleischmann
mesh_terms: D000818:Animals; D001672:Biocompatible Materials; D001696:Biomechanical Phenomena; D001863:Bone Screws; D017886:Durapatite; D005592:Fracture Fixation; D012756:Sheep; D013978:Tibial Fractures / Q000601:surgery*
chemical_list: D001672:Biocompatible Materials; D017886:Durapatite