title: Purine nucleotide metabolism in lymphocytes of B-cell chronic lymphocytic leukemia patients.
abstract: Purine nucleotides were studied in human peripheral blood lymphocytes from normal subjects and patients with chronic B-cell lymphocytic leukemia (B-CLL). Nucleotide content was determined by high performance liquid chromatography (HPLC). The overall rate of purine nucleotide synthesis was measured following the incorporation of 14C-formate into the nucleotides of a lymphocytic suspension. Results indicate a substantially reduced rate of purine nucleotide metabolism.
authors.affiliation: Istituto di Biochimica e di Enzimologia, Università di Siena, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Tabucchi
authors.forename: F
authors.initials: F
authors.lastname: Carlucci
authors.forename: R
authors.initials: R
authors.lastname: Leoncini
authors.forename: D
authors.initials: D
authors.lastname: Vannoni
authors.forename: E
authors.initials: E
authors.lastname: Consolmagno
authors.forename: E
authors.initials: E
authors.lastname: Marinello
authors.forename: M
authors.initials: M
authors.lastname: Pizzichini
authors.forename: E
authors.initials: E
authors.lastname: Dispensa
authors.forename: R
authors.initials: R
authors.lastname: Pagani
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D015451:Leukemia, Lymphocytic, Chronic, B-Cell / Q000378:metabolism*; D008214:Lymphocytes / Q000378:metabolism*; D008875:Middle Aged; D011685:Purine Nucleotides / Q000378:metabolism*
chemical_list: D011685:Purine Nucleotides