title: Fusacandins A and B; novel antifungal antibiotics of the papulacandin class from Fusarium sambucinum. I. Identity of the producing organism, fermentation and biological activity.
abstract: The fuscandins, antifungal agents of the papulacandin class, are produced by a strain of Fusarium sambucinum. Fermentation yielded 60 mg/liter of fusacandin A and minor amounts of fusacandin B. As expected, the fusacandins inhibit (1,3)-beta-glucan synthesis. Fusacandin A is slightly less active than papulacandin B against Candida albicans and, like papulacandin, loses activity in the presence of serum.
authors.affiliation: Abbott Laboratories, Abbott Park, IL 60064, USA.
authors.forename: M
authors.initials: M
authors.lastname: Jackson
authors.forename: D J
authors.initials: DJ
authors.lastname: Frost
authors.forename: J P
authors.initials: JP
authors.lastname: Karwowski
authors.forename: P E
authors.initials: PE
authors.lastname: Humphrey
authors.forename: S K
authors.initials: SK
authors.lastname: Dahod
authors.forename: W S
authors.initials: WS
authors.lastname: Choi
authors.forename: K
authors.initials: K
authors.lastname: Brandt
authors.forename: L H
authors.initials: LH
authors.lastname: Malmberg
authors.forename: R R
authors.initials: RR
authors.lastname: Rasmussen
authors.forename: M H
authors.initials: MH
authors.lastname: Scherr
mesh_terms: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D005670:Fusarium; D008826:Microbial Sensitivity Tests; D009844:Oligosaccharides / Q000302:isolation & purification / Q000494:pharmacology
chemical_list: D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D009844:Oligosaccharides; C095339:fusacandin A; C095340:fusacandin B; C020789:papulacandin B