title: Effect of an acidic environment on the susceptibility of Helicobacter pylori to trospectomycin and other antimicrobial agents.
abstract: The susceptibility of 30 clinical isolates of Helicobacter pylori to trospectomycin, ampicillin, metronidazole, clarithromycin, azithromycin and clindamycin under varying pH conditions was evaluated. An acidic environment was shown to affect unfavourably the activity of all the antimicrobial agents tested. This pH effect was most marked for the two macrolides and for clindamycin.
authors.affiliation: Department of Clinical Microbiology, Free University Hospital, Amsterdam, The Netherlands.
authors.forename: Y J
authors.initials: YJ
authors.lastname: Debets-Ossenkopp
authors.forename: F
authors.initials: F
authors.lastname: Namavar
authors.forename: D M
authors.initials: DM
authors.lastname: MacLaren
mesh_terms: D000667:Ampicillin / Q000494:pharmacology; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D017963:Azithromycin / Q000494:pharmacology; D017291:Clarithromycin / Q000494:pharmacology; D002981:Clindamycin / Q000494:pharmacology; D016480:Helicobacter pylori / Q000187:drug effects* / Q000254:growth & development*; D006801:Humans; D006863:Hydrogen-Ion Concentration; D008795:Metronidazole / Q000494:pharmacology; D008826:Microbial Sensitivity Tests; D000198:Spectinomycin / Q000031:analogs & derivatives* / Q000494:pharmacology
chemical_list: D000900:Anti-Bacterial Agents; D008795:Metronidazole; D002981:Clindamycin; C043267:trospectomycin; D000667:Ampicillin; D017963:Azithromycin; D000198:Spectinomycin; D017291:Clarithromycin