Angiosarcoma of the breast and pregnancy: a new therapeutic approach.
A case of angiosarcoma of the breast managed primarily by a chemotherapeutic approach is referred. A 29-year-old patient presented complaining of a painful mass in her right breast. An incisional biopsy carried out under general anesthesia showed a moderately-differentiated angiosarcoma surrounded by fibrofatty tissue. Ruled out distant metastases, a decision was made to initiate neoadjuvant chemotherapy consisting of ifosfamide, vincristine and dactinimycin. After 2 courses of chemotherapy the tumor volume was reduced by 50% and the histologic examination of the mastectomy specimen revealed a well-differentiated angiosarcoma with widespread areas of necrosis probably produced by previous chemotherapic treatment. The patient is clinically free of disease after 24 months of follow-up. Although this is a single case report, and by no means can be considered a guideline for future treatments, we nevertheless feel that the result obtained with the chemotherapeutic approach with this patient is encouraging.
Barrenetxea
G
G
Department of Obstetrics and Gynecology, Hospital de Cruces (Ginecología), Universidad del Pais Vasco, Baracalado, Bilbao, Spain.
Schneider
J
J
Tánago
J G
JG
Pérez
C
C
Centeno
M M
MM
Rodríguez-Escudero
F J
FJ
D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use; D001943:Breast Neoplasms / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D003609:Dactinomycin / Q000008:administration & dosage; D005260:Female; D006394:Hemangiosarcoma / Q000188:drug therapy* / Q000473:pathology / Q000601:surgery; D006801:Humans; D007069:Ifosfamide / Q000008:administration & dosage; D015413:Mastectomy, Simple; D011247:Pregnancy; D011252:Pregnancy Complications, Neoplastic; D014750:Vincristine / Q000008:administration & dosage
D003609:Dactinomycin; D014750:Vincristine; D007069:Ifosfamide