title: Clinical and radiographic progression of fibrous dysplasia: cystic change or sarcoma? Description of a clinical case and review of the literature.
abstract: The clinical and radiographic progression of fibrous dysplasia may be due to a cystic-hemorrhagic change, or to a sarcomatous transformation. The distinction between these two possibilities, which is essential to treatment, depend on the biopsy. A case of fibrous dysplasia in a female aged 18 years is described in which, 3 years after pathologic fracture consolidated with non-surgical treatment, clinical and radiographic progression occurred, enough to suspect malignant transformation. Histological diagnosis showed fibrous dysplasia with a cartilaginous component and cystic-hemorrhagic changes, and curettage-bone allografting resulted in healing of the lesion.
authors.affiliation: 1a Clinica Ortopedica dell'Università di Bologna.
authors.forename: F
authors.initials: F
authors.lastname: De Iure
authors.forename: L
authors.initials: L
authors.lastname: Campanacci
mesh_terms: D000293:Adolescent; D001706:Biopsy; D001845:Bone Cysts / Q000175:diagnosis; D001859:Bone Neoplasms / Q000175:diagnosis; D016025:Bone Transplantation; D003475:Curettage; D003937:Diagnosis, Differential; D005260:Female; D005265:Femoral Neck Fractures / Q000209:etiology; D005357:Fibrous Dysplasia of Bone / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery*; D005598:Fractures, Spontaneous / Q000209:etiology; D006801:Humans; D012509:Sarcoma / Q000175:diagnosis