Tyrosinase inhibitors from Bolivian medicinal plants.
Bioassay-guided fractionation monitored by mushroom tyrosinase (EC 1.14.18.1) activity, afforded six inhibitors from three Bolivian medicinal plants, Buddleia coriacea, Gnaphalium cheiranthifolium, and Scheelea princeps. These inhibitors, which are all known phenolic compounds, inhibited the oxidation of L-3,4-dihydroxyphenylalanine (L-DOPA) mediated by a mushroom tyrosinase.
Kubo
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I
Department of Environmental Science, Policy, and Management, University of California, Berkeley 94720-3112, USA.
Yokokawa
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Y
Kinst-Hori
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I
D001487:Basidiomycota / Q000201:enzymology; D001838:Bolivia; D014442:Monophenol Monooxygenase / Q000037:antagonists & inhibitors*; D010946:Plants, Medicinal / Q000737:chemistry*
D014442:Monophenol Monooxygenase