Anticonvulsant activity of Casimiroa edulis in comparison to phenytoin and phenobarbital.
An aqueous extract of Casimiroa edulis leaves was tested in adult male Wistar rats for anticonvulsant activity utilizing two models of experimental epilepsy: maximal electroshock seizure (MES) and subcutaneously injected metrazole (METsc). Single dose of 100 mg/kg C. edulis vacuum dried aqueous extracts (VDA) orally administered to experimental animals elicited 50% and 70% abolition of MES and METsc-induced seizures, respectively. Two firmly established antiepileptic drugs in human therapy, phenytoin (PHT) and phenobarbital (PB), abolished 90% of MES-induced seizures, whereas an 80% and 100% absence of clonic seizures was attained in METsc test, correspondingly. The seizure abolition observed in C. edulis VDA treated rats was comparable with the anticonvulsive pattern exhibited by PHT and PB. These results suggest that potencially antiepileptic compounds are present in C. edulis extracts that deserve the study of their identity and mechanism of action.
Navarro Ruíz
A
A
División de Bioquímica-Farmacológica, Unidad de Investigación Biomédica de Occidente, C.M.O., Instituto Mexicano del Seguro Social, Mexico.
Bastidas Ramírez
B E
BE
García Estrada
J
J
García López
P
P
Garzón
P
P
D000284:Administration, Oral; D000818:Animals; D000927:Anticonvulsants / Q000008:administration & dosage / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004597:Electroshock; D007279:Injections, Subcutaneous; D008297:Male; D008800:Mexico; D010433:Pentylenetetrazole / Q000008:administration & dosage / Q000633:toxicity; D010634:Phenobarbital / Q000008:administration & dosage / Q000627:therapeutic use*; D010672:Phenytoin / Q000008:administration & dosage / Q000627:therapeutic use*; D010936:Plant Extracts / Q000008:administration & dosage / Q000627:therapeutic use*; D018515:Plant Leaves; D051381:Rats; D017208:Rats, Wistar; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy*
D000927:Anticonvulsants; D010936:Plant Extracts; D010672:Phenytoin; D010433:Pentylenetetrazole; D010634:Phenobarbital