Cloning of the gene encoding human somatostatin receptor 2: sequence analysis of the 5'-flanking promoter region.
Using a cDNA probe, genomic clones were obtained for the 5' flanking promoter sequence of the human somatostatin receptor 2-encoding gene (SSTR2). A 3.8-kb sequence directly upstream from the start codon was analyzed. This sequence shares a number of characteristics with the promoters of other G-protein-coupled receptor (GPCR)-encoding genes including a number of G+C-rich regions, binding sites for several transcriptional factors, and the absence of coupled TATAA and CAAT sequences.
Greenwood
M T
MT
Fraser Laboratories, Department of Medicine, McGill University, Royal Victoria Hospital, Montreal, Québec, Canada.
Robertson
L A
LA
Patel
Y C
YC
D001483:Base Sequence; D003001:Cloning, Molecular; D006801:Humans; D008969:Molecular Sequence Data; D011401:Promoter Regions, Genetic / Q000235:genetics*; D017481:Receptors, Somatostatin / Q000235:genetics*; D017422:Sequence Analysis, DNA
D017481:Receptors, Somatostatin; C093733:somatostatin receptor 2