Successful treatment of amoxapine-induced refractory status epilepticus with propofol (diprivan)
Tonic-clonic seizure activity is a recognized complication of amoxapine overdose. Refractory drug-induced status epilepticus is associated with significant morbidity and mortality. Standard regimens for controlling status epilepticus may be ineffective for aborting drug-induced seizures. The authors report the case of a 30-year-old woman who presented with an amoxapine overdose that deteriorated into status epilepticus refractory to conventional therapy. Propofol given by intravenous bolus and maintenance infusion successfully halted the patient's seizure activity. This case suggests that propofol may be effective as an anticonvulsant in refractory drug-induced status epilepticus.
Merigian
K S
KS
Department of Emergency Medicine, University of Tennessee, Memphis, USA.
Browning
R G
RG
Leeper
K V
KV
D000328:Adult; D000657:Amoxapine / Q000009:adverse effects*; D062787:Drug Overdose; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D015742:Propofol / Q000008:administration & dosage / Q000627:therapeutic use*; D013226:Status Epilepticus / Q000139:chemically induced* / Q000188:drug therapy*
D000657:Amoxapine; D015742:Propofol