Complete atrioventricular cardiac transplantation: improved performance compared with the standard technique.
BACKGROUND
There has been renewed clinical interest in an alternative technique to orthotopic cardiac transplantation involving six anastomoses: left pulmonary veins, right pulmonary veins, inferior vena cava, pulmonary artery, aorta, and superior vena cava (complete technique). In this study, the results of the complete technique are compared with those of the standard operation (ventricular transplantation with atrioplasty).


METHODS
Dogs were used for ten acute standard and ten acute complete atrioventricular transplantations. There were no significant differences in the baseline cardiac function (preload-independent right and left ventricular recruitable stroke work), bypass times, and cardiac ischemic times between the two groups.


RESULTS
After transplantation, sinus rhythm was preserved after all ten complete and after only one standard transplantation but no significant hemodynamic differences were observed. The right and left ventricular preload-independent recruitable stroke work in the complete group and the left ventricular preload-independent recruitable stroke work in the standard group were conserved after transplantation, but the right ventricular preload-independent recruitable stroke work decreased by 39% +/- 8% (p < 0.05) in the standard group. There was also a significant decrease in the rate of biventricular filling in the standard group after transplantation.


CONCLUSIONS
Complete atrioventricular transplantation is a feasible alternative technique and conserves normal sinus rhythm. The ischemic and bypass times are comparable for both methods. The insignificant change in the rate of biventricular filling in the dogs undergoing the complete technique indicates right and left ventricular diastolic function may be conserved after transplantation.
Bittner
H B
HB
Department of General and Cardiothoracic Surgery, Duke University Medical Center, Durham, NC 27710, USA.
Kendall
S W
SW
Chen
E P
EP
Davis
R D
RD
Van Trigt
P
P
D000818:Animals; D016275:Atrial Function; D004285:Dogs; D016027:Heart Transplantation / Q000379:methods* / Q000502:physiology; D006439:Hemodynamics; D013318:Stroke Volume; D016276:Ventricular Function