[Effect of Tibetan compound prescription on cardiac haemodynamics in experimental myocardial ischemia in dogs].
35 healthy and hybrid dogs were divided into the control group (5 dogs), ischemic group (15 dogs) and medicated group (15 dogs). The myocardial ischemia model was produced by ligating the left coronary artery between the branch 2 and 3 among the anterior descending branches. The effect of the herbs on the experimental myocardial ischemia was observed by measuring the Mean Artery Pressure (MAP), the Left Ventricular End Diastolic Pressure (LVEDP), the Heart Rate (HR), the Cardiac Output (CO) and the Cardiac Index (CI) etc. The results showed that the LVEDP was significantly increased and the MAP, the CO and the CI were lowered during the period of myocardial ischemia, which indicated the disorder of cardiac heaemodynamics after the myocardial ischemia, By taking the medicine through the duodenum in the medicated group, the CO was obviously increased during the period of myocardial ischemia and also the CI was elevated prominently. The investigation indicated that the medicine could reinforce the cardiac pump function and adjust the disorder of cardiac haemodynamics resulted from myocardial ischemia.
Zhang
Y J
YJ
Hainan Provincial TCM Hospital, Haikou.
Hou
Y
Y
Cao
Y B
YB
D000818:Animals; D002302:Cardiac Output / Q000187:drug effects; D004285:Dogs; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects*; D008297:Male; D017202:Myocardial Ischemia / Q000188:drug therapy / Q000503:physiopathology*; D011897:Random Allocation; D016277:Ventricular Function, Left / Q000187:drug effects
D004365:Drugs, Chinese Herbal