title: [Several mechanisms of immunological adaptation in the etiology of subacute infectious endocarditis].
abstract: The paper deals with the possibility of identifying the persons predisposed to the development of subacute septic endocarditis (SSE), with the prediction of the course of the disease and the clarification of reasons for the inefficiency of antibacterial therapy. The studies performed revealed the impairment of cooperative interaction of the immune system, which prevents it from fulfilling its main task, i.e. to make an immunological surveillance over the maintenance of internal constancy. Imperfection of this function in SSE patients and rheumatic heart diseases is based on the body's sharply limited adaptation which results from the genetically determined low values of the immune functional reserve realizable by the level of intracellular energy processes which are substantially lower in SSE patients, as evidenced by the studies conducted. This is very important for predicting whether it may develop in some patients with rheumatic diseases. The necessity of using large doses of antibiotics decreases the activity of intracellular processes to a greater extent, aggravating primarily phagocytic function, as reflected in the efficiency of antibiotic therapy.
authors.forename: D V
authors.initials: DV
authors.lastname: Belokrinitskiĭ
authors.forename: O A
authors.initials: OA
authors.lastname: Belokrinitskaia
authors.forename: M V
authors.initials: MV
authors.lastname: Taranova
authors.forename: L G
authors.initials: LG
authors.lastname: Gorina
authors.forename: N Iu
authors.initials: NIu
authors.lastname: Niaĭkina
authors.forename: A N
authors.initials: AN
authors.lastname: Poliakov
mesh_terms: D000328:Adult; D000368:Aged; D004698:Endocarditis, Subacute Bacterial / Q000276:immunology*; D005260:Female; D006801:Humans; D007136:Immunoglobulins / Q000032:analysis; D008297:Male; D008875:Middle Aged; D010587:Phagocytosis; D012214:Rheumatic Heart Disease / Q000276:immunology; D012397:Rosette Formation
chemical_list: D007136:Immunoglobulins
vernacular_title: O nekotorykh mekhanizmakh immunologicheskoĭ adaptatsii pri razvitii podostrogo infektsionnogo éndokardita.