title: Identification and analysis of a 'young' polymorphic Alu element.
abstract: A polymorphic Alu element belonging to a young subfamily of Alu repeats has been identified. Sequence analysis showed that this Alu element is flanked by perfect direct repeats and a 3' oligo(dA)-rich tail. The Alu element, designated A25, is deleted by 34 nucleotides at the 5' end and has a single CpG mutation compared to the human-specific consensus sequence. Using a PCR-based assay, we demonstrated that the A25 Alu repeat is localized to human chromosome 8 and is polymorphic in humans.
authors.affiliation: Human Genome Center, Lawrence Livermore National Laboratory, CA 94551, USA.
authors.forename: S S
authors.initials: SS
authors.lastname: Arcot
authors.forename: J J
authors.initials: JJ
authors.lastname: Fontius
authors.forename: P L
authors.initials: PL
authors.lastname: Deininger
authors.forename: M A
authors.initials: MA
authors.lastname: Batzer
mesh_terms: D001435:Bacteriophages / Q000378:metabolism; D001483:Base Sequence; D005787:Gene Frequency; D006367:HeLa Cells; D006801:Humans; D008969:Molecular Sequence Data; D011110:Polymorphism, Genetic; D012091:Repetitive Sequences, Nucleic Acid / Q000235:genetics*