Production of the new antibiotic tetrahydrokalafungin by transformants of the kalafungin producer Streptomyces tanashiensis.
The new antibiotic tetrahydrokalafungin was produced by the transformants of kalafungin producing S. tanashiensis and kalafungin-nonproducing mutants carrying the recombinant plasmid pKU523. This plasmid consists of pKU501 (J. Antibiotics 44: 995 approximately 1005, 1991) which contains the gene cluster for kalafungin biosynthesis, and additional 5 kb stability region of SCP2*.
Kakinuma
S
S
School of Pharmaceutical Sciences, Kitasato University, Kitasato Institute, Tokyo, Japan.
Ikeda
H
H
Takada
Y
Y
Tanaka
H
H
Hopwood
D A
DA
Omura
S
S
D000900:Anti-Bacterial Agents / Q000096:biosynthesis* / Q000737:chemistry / Q000302:isolation & purification; D015394:Molecular Structure; D009285:Naphthoquinones / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D010957:Plasmids; D013302:Streptomyces / Q000235:genetics; D013329:Structure-Activity Relationship; D000095622:Benzoisochromanequinones
D000900:Anti-Bacterial Agents; D009285:Naphthoquinones; C094830:tetrahydrokalafungin; C013079:kalafungin; D000095622:Benzoisochromanequinones