Liver transplantation and haemophilia A.
Liver transplantation has become the standard treatment for a variety of inherited metabolic disorders. We report on two patients who underwent successful transplantation for posthepatitis viral cirrhosis, which developed following blood factor replacement for haemophilia A. The second patient was transplanted before the occurrence of major complications of either his liver or haemophilic disease. We propose early liver transplantation to achieve metabolic cure of haemophilia.
Lerut
J P
JP
Department of Digestive Surgery, University Hospitals St. Luc, Catholic University of Louvain, Medical School, Brussels, Belgium.
Laterre
P F
PF
Lavenne-Pardonge
E
E
Donataccio
M
M
Geubel
A
A
Reynaert
M S
MS
Otte
J B
JB
D000328:Adult; D001779:Blood Coagulation Factors / Q000009:adverse effects*; D006467:Hemophilia A / Q000150:complications / Q000628:therapy*; D006525:Hepatitis, Viral, Human / Q000209:etiology*; D006801:Humans; D008103:Liver Cirrhosis / Q000821:virology*; D016031:Liver Transplantation; D008297:Male; D008875:Middle Aged
D001779:Blood Coagulation Factors