Comparative effects of recombinant human insulin-like growth factor I and insulin on whole-body and forearm palmitate metabolism in man.
1. The effects of intravenous infusions of recombinant human insulin-like growth factor I and insulin on palmitate kinetics, lipolysis and on serum triacylglycerol were compared. Overnight-fasted normal subjects received high doses of insulin-like growth factor I (30 micrograms h-1 kg-1) and insulin (0.23 nmol h-1 kg-1; group 1), low doses of insulin-like growth factor I (5 micrograms h-1 kg-1) and insulin (0.04 nmol h-1 kg-1; group 2) or saline (control group). The doses of insulin-like growth factor I and insulin were equipotent with regard to increases in glucose uptake during 8 h euglycaemic clamping. 2. Whole-body palmitate flux (measured by continuous infusions of [2,2-D2]palmitate) was lowered dose-dependently by 68% +/- 6% during insulin-like growth factor I and by 82% +/- 2% during insulin after 8 h of infusions of high doses (insulin-like growth factor I versus insulin; not significant). Plasma palmitate, glycerol and triacylglycerol concentrations had decreased to a similar extent at the end of the infusions of both peptides at either dose. 3. The present results demonstrate that insulin-like growth factor I and insulin infused at doses which result in identical increases in glucose uptake during euglycaemic clamping are equipotent inhibitors of lipolysis.
Laager
R
R
Department of Research and Internal Medicine, University of Basle, Switzerland.
Ninnis
R
R
Keller
U
U
D000328:Adult; D001786:Blood Glucose / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D005542:Forearm / Q000098:blood supply; D005990:Glycerol / Q000097:blood; D006801:Humans; D007262:Infusions, Intravenous; D007328:Insulin / Q000494:pharmacology*; D007334:Insulin-Like Growth Factor I / Q000494:pharmacology*; D008066:Lipolysis / Q000187:drug effects; D008297:Male; D010168:Palmitates / Q000097:blood / Q000378:metabolism*; D011994:Recombinant Proteins / Q000494:pharmacology; D014280:Triglycerides / Q000097:blood
D001786:Blood Glucose; D007328:Insulin; D010168:Palmitates; D011994:Recombinant Proteins; D014280:Triglycerides; D007334:Insulin-Like Growth Factor I; D005990:Glycerol