title: [Precocious puberty and hypothalamic hamartoma: treatment with triptorelin during eight years].
abstract: BACKGROUND
  Hypothalamic hamartoma, a rare cause of true sexual precocity, may develop slowly so that its diagnosis may be late.
  
  
  METHODS
  A 7 1/2-month-old girl was admitted because she suffered from development of physical pubertal changes. Laboratory tests were consistent with premature activation of the hypothalamic-pituitary axis. Initial neuroradiological investigation failed to find any cause. The patient was given medroxyprogesterone that resulted in regression of secondary sexual characteristics but growth rates and skeletal maturity remained accelerated. For that reason, the patient was given triptorexine, LH-RH analogue, 18 months later that resulted in a deceleration of puberty growth rate and skeletal maturity. MRI performed at the age of 9 years showed a small hypothalamic hamartoma and the LH-RH analogue was stopped at the age of 10 years.
  
  
  CONCLUSIONS
  MRI is now the best technique for investigating the hypothalamo-hypophyseal area.
authors.affiliation: Service de pédiatrie 1, hôpital Font-Pré, Toulon, France.
authors.forename: J M
authors.initials: JM
authors.lastname: Chamouilli
authors.forename: B
authors.initials: B
authors.lastname: Razafimahefa
authors.forename: H
authors.initials: H
authors.lastname: Pierron
mesh_terms: D004305:Dose-Response Relationship, Drug; D005260:Female; D006222:Hamartoma / Q000150:complications* / Q000175:diagnosis; D006801:Humans; D007027:Hypothalamic Diseases / Q000150:complications* / Q000175:diagnosis; D007223:Infant; D008279:Magnetic Resonance Imaging; D011629:Puberty, Precocious / Q000188:drug therapy* / Q000209:etiology*; D017329:Triptorelin Pamoate / Q000008:administration & dosage / Q000627:therapeutic use*
chemical_list: D017329:Triptorelin Pamoate
vernacular_title: Puberté précocissime et hamartome hypothalamique: traitement par triptoréline durant 8 ans.