title: Gamma-indomycinone, a new pluramycin metabolite from a deep-sea derived actinomycete.
abstract: A new member of the pluramycin class of antibiotics, gamma-indomycinone [1], has been isolated along with the known compounds rubiflavinone C-1 [2] and beta-indomycinone [3] from the culture broth of a Streptomyces sp. obtained from a deep-sea sediment core. Each compound is composed of an anthraquinone-gamma-pyrone nucleus, but bears a different side-chain. Compounds 2 and 3 were identified by comparison of their spectral data with published data, while gamma-indomycinone [1] was characterized using 1H-nmr and mass spectrometry.
authors.affiliation: Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822, USA.
authors.forename: R W
authors.initials: RW
authors.lastname: Schumacher
authors.forename: B S
authors.initials: BS
authors.lastname: Davidson
authors.forename: D A
authors.initials: DA
authors.lastname: Montenegro
authors.forename: V S
authors.initials: VS
authors.lastname: Bernan
mesh_terms: D000880:Anthraquinones / Q000302:isolation & purification / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000302:isolation & purification* / Q000494:pharmacology; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D011753:Pyrones / Q000302:isolation & purification / Q000494:pharmacology; D013302:Streptomyces / Q000737:chemistry*; D014407:Tumor Cells, Cultured
chemical_list: D000880:Anthraquinones; D000903:Antibiotics, Antineoplastic; D011753:Pyrones; C094791:gamma-indomycinone