Effect of cuprofilin on experimental atherosclerosis.
The effect of Cuprofilin, a newly synthesized C.(II)-chlorophyll complex, was assessed in rats with experimental atherosclerosis. The study was focused on changes in serum cholesterol, lipids, and triglycerides concentration as well as on serum and abdominal aorta Cu and Zn values. It has been ascertained that after 90 d in animals fed a rich lipid diet there was a statistically significant increase in serum cholesterol, triglycerides, and lipid concentration (p < 0.01). A significant augmentation of serum Cu values (p < 0.01) accompanied by a marked lowering of the same element in abdominal aorta (p < 0.01) was also found, as compared to the results registered in the control group. However, Cuprofilin, administered for 90 d in the group of animals with experimental atherosclerosis, significantly decreased the serum cholesterol, triglycerides, and serum lipid values (p < 0.01), increased copper content in aortic tissue (p < 0.01) and lowered serum copper concentration (p < 0.01) as compared to the untreated group. Moreover, in the aorta of administered animals the lipid infiltration has been demonstrated to be significantly diminished vs the untreated group.
Vlad
M
M
Institute of Public Health and Medical Research, University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Bordas
E
E
Caseanu
E
E
Uza
G
G
Creteanu
E
E
Polinicenco
C
C
D000284:Administration, Oral; D000818:Animals; D001012:Aorta, Abdominal / Q000378:metabolism / Q000473:pathology; D001161:Arteriosclerosis / Q000188:drug therapy*; D002734:Chlorophyll / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002735:Chlorophyllides / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D002784:Cholesterol / Q000097:blood; D002791:Cholesterol, Dietary / Q000008:administration & dosage; D003300:Copper / Q000008:administration & dosage / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D008055:Lipids / Q000097:blood; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013054:Spectrophotometry, Atomic; D014018:Tissue Distribution; D014280:Triglycerides / Q000097:blood; D015032:Zinc / Q000097:blood / Q000378:metabolism
D002735:Chlorophyllides; D002791:Cholesterol, Dietary; D008055:Lipids; D014280:Triglycerides; D002734:Chlorophyll; D003300:Copper; D002784:Cholesterol; C007020:chlorophyllin; D015032:Zinc