Prevention of post-infarction left ventricular remodeling by ACE-inhibitors.
Left ventricular remodeling post-infarction occurs in at least a third of patients post-infarction and is associated with diminished survival and an increased incidence of adverse cardiovascular events. This process, which has been well described in recent years, can be largely attenuated with the use of ACE-inhibitors and with it survival improved and adverse events minimized. Since it is currently not possible to identify people at risk from left ventricular remodeling, ACE-inhibitors should be administered to all patients within the first 48 hours of infarction.
St John Sutton
M
M
Department of Cardiology, University of Pennsylvania, Philadelphia, USA.
Pfeffer
M A
MA
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use*; D002986:Clinical Trials as Topic; D006352:Heart Ventricles / Q000473:pathology*; D006801:Humans; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000517:prevention & control*; D009203:Myocardial Infarction / Q000150:complications* / Q000473:pathology
D000806:Angiotensin-Converting Enzyme Inhibitors