title: Lipid peroxidation in rats intoxicated with 3-nitropropionic acid.
abstract: Using an electron spin resonance technique, free radical signals were observed to be increased in liver of rats 15, 30 and 45 min after orally dosing with 80 mg/kg 3-nitropropionic acid (3-NPA). Concentrations of 3-NPA from 595 to 2380 mg/litre enhanced the formation of adrenochrome from adrenaline in mitochondria and microsome suspensions of liver and brain. The activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) as well as the content of malonidialdehyde (MDA) were significantly increased in liver of rats dosed with 80 mg/kg 3-NPA. There was also a cerebral increase of activity of SOD and content of MDA. These results suggest that 3-NPA is able to produce lipid peroxidation both in vivo and in vitro.
authors.affiliation: Institute of Occupational Medicine, Chinese Academy of Preventive Medicine, Beijing.
authors.forename: Y T
authors.initials: YT
authors.lastname: Fu
authors.forename: F S
authors.initials: FS
authors.lastname: He
authors.forename: S L
authors.initials: SL
authors.lastname: Zhang
authors.forename: J S
authors.initials: JS
authors.lastname: Zhang
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001921:Brain / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D004578:Electron Spin Resonance Spectroscopy; D005609:Free Radicals / Q000009:adverse effects / Q000032:analysis; D005979:Glutathione Peroxidase / Q000378:metabolism; D066298:In Vitro Techniques; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000201:enzymology / Q000378:metabolism; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D008862:Microsomes, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D008930:Mitochondria, Liver / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D009498:Neurotoxins / Q000008:administration & dosage / Q000633:toxicity*; D009574:Nitro Compounds; D010936:Plant Extracts / Q000008:administration & dosage / Q000633:toxicity; D011422:Propionates / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017208:Rats, Wistar; D013482:Superoxide Dismutase / Q000378:metabolism
chemical_list: D005609:Free Radicals; D009498:Neurotoxins; D009574:Nitro Compounds; D010936:Plant Extracts; D011422:Propionates; D008315:Malondialdehyde; D005979:Glutathione Peroxidase; D013482:Superoxide Dismutase; C015392:3-nitropropionic acid