Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin: homologous peptides, separate receptors and overlapping biological actions.
Calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin are structurally related peptides with N-terminal 6-7 amino acid ring structures linked by a disulfide bridge and with amidated C-termini. Among the related bioactive peptides, the structures of the calcitonin receptor and subtypes thereof have been identified so far through molecular cloning. Cross-reaction between receptors of calcitonin, calcitonin gene-related peptide, adrenomedullin and amylin, as well as overlapping biological actions, anticipate that the respective receptors belong to a family of G-protein-coupled receptors that include those of parathyroid hormone, secretin and vasointestinal peptide.
Muff
R
R
Department of Orthopaedic Surgery, University of Zurich, Switzerland.
Born
W
W
Fischer
J A
JA
D053607:Adrenomedullin; D000595:Amino Acid Sequence; D000682:Amyloid / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D000818:Animals; D000959:Antihypertensive Agents / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D002116:Calcitonin / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D015740:Calcitonin Gene-Related Peptide / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D002135:Calcium-Binding Proteins / Q000032:analysis / Q000378:metabolism; D006801:Humans; D058228:Islet Amyloid Polypeptide; D008969:Molecular Sequence Data; D010455:Peptides / Q000032:analysis* / Q000737:chemistry / Q000378:metabolism; D058265:Receptors, Adrenomedullin; D018015:Receptors, Calcitonin Gene-Related Peptide / Q000032:analysis / Q000378:metabolism; D058287:Receptors, Islet Amyloid Polypeptide; D018000:Receptors, Peptide / Q000032:analysis / Q000378:metabolism; D017386:Sequence Homology, Amino Acid
D000682:Amyloid; D000959:Antihypertensive Agents; D002135:Calcium-Binding Proteins; D058228:Islet Amyloid Polypeptide; D010455:Peptides; D058265:Receptors, Adrenomedullin; D018015:Receptors, Calcitonin Gene-Related Peptide; D058287:Receptors, Islet Amyloid Polypeptide; D018000:Receptors, Peptide; D053607:Adrenomedullin; D002116:Calcitonin; D015740:Calcitonin Gene-Related Peptide