title: Comparison of dose-response slopes obtained by simultaneous assessment of changes in FEV1 and transcutaneous oxygen partial pressure during methacholine challenges in asthmatic patients.
abstract: We aimed to ascertain whether monitoring changes in transcutaneous (tc) oxygen partial pressure (PO2) may be used to determine the slope of the dose-response curves to inhaled methacholine. In 10 adult asthmatic patients, FEV1 and tcPO2 were simultaneously measured during inhalation of doubling methacholine concentrations. In each patient, the slopes of the methacholine dose-response curves for FEV1 and tcPO2 were similar and strongly correlated (r = 0.72; p < 0.05). The results indicate that tcPO2 monitoring represents a useful, reliable tool for analysis of the slope of dose-response curves to inhaled methacholine in asthmatic patients. It can also be used to investigate the pathophysiological implications of bronchial hyperreactivity.
authors.affiliation: Dipartimento di Fisiopatologia Clinica, Università di Firenze, Florence, Italy.
authors.forename: G A
authors.initials: GA
authors.lastname: Fontana
authors.forename: F
authors.initials: F
authors.lastname: Lavorini
authors.forename: V
authors.initials: V
authors.lastname: Boddi
authors.forename: G
authors.initials: G
authors.lastname: Camiciottoli
authors.forename: P
authors.initials: P
authors.lastname: Panuccio
mesh_terms: D000328:Adult; D001249:Asthma / Q000097:blood / Q000175:diagnosis* / Q000503:physiopathology; D001785:Blood Gas Monitoring, Transcutaneous; D016535:Bronchial Hyperreactivity / Q000503:physiopathology; D001985:Bronchial Provocation Tests; D004305:Dose-Response Relationship, Drug; D005260:Female; D005541:Forced Expiratory Volume; D006801:Humans; D008297:Male; D016210:Methacholine Chloride / Q000008:administration & dosage
chemical_list: D016210:Methacholine Chloride