Increased bone resorption and decreased bone formation in Chinese patients with hip fracture.
Biochemical markers of bone formation (bone-specific alkaline phosphatase and osteocalcin) and bone resorption (hydroxyproline excretion and bone isoenzyme of acid phosphatase) were measured in 30 patients (15 M and 15 F) with hip fracture and 30 healthy subjects matched for age and sex. Bone isoenzyme of tartrate-resistant acid phosphatase (TRACP) was measured by a recently developed specific immunoassay. Serum osteocalcin concentration and bone-specific alkaline phosphatase activity were significantly lower and serum TRACP concentration and urinary hydroxyproline excretion were elevated in patients compared with healthy subjects. We suggest that there is reduced bone formation and increased bone resorption in patients with hip fracture.
Cheung
C K
CK
Department of Chemical Pathology, Chinese University of Hong Kong, Shatin.
Panesar
N S
NS
Lau
E
E
Woo
J
J
Swaminathan
R
R
D000135:Acid Phosphatase / Q000097:blood*; D000368:Aged; D000369:Aged, 80 and over; D000469:Alkaline Phosphatase / Q000097:blood*; D015415:Biomarkers / Q000097:blood / Q000652:urine; D001846:Bone Development; D001862:Bone Resorption; D002112:Calcifediol / Q000097:blood; D002117:Calcitriol / Q000097:blood; D002681:China; D015331:Cohort Studies; D005260:Female; D006620:Hip Fractures / Q000453:epidemiology / Q000503:physiopathology*; D006801:Humans; D006909:Hydroxyproline / Q000652:urine; D007527:Isoenzymes / Q000097:blood; D008297:Male; D008875:Middle Aged; D015675:Osteocalcin / Q000097:blood*; D010281:Parathyroid Hormone / Q000097:blood; D012016:Reference Values; D012307:Risk Factors
D015415:Biomarkers; D007527:Isoenzymes; D010281:Parathyroid Hormone; D015675:Osteocalcin; D000469:Alkaline Phosphatase; D000135:Acid Phosphatase; D002117:Calcitriol; D002112:Calcifediol; D006909:Hydroxyproline