title: A comparative cerebral blood flow study in a baboon model with acetazolamide provocation: 99mTc-HMPAO vs 123I(IMP).
abstract: Pharmacological interactions are important when nuclear medical procedures are applied to patients under drug therapy, or drug provocation. This study compares in baboon models (regional) cerebral blood flow [(r)CBF] results from 99mTc-HMPAO and 123I-iodoamphetamine [123I(IMP)] each with and without acetazolamide, the latter a suggested drug for testing cerebrovascular reserve. Expected differences in cerebral uptake were observed between the two radio-tracers without acetazolamide. The increase in tracer uptake resulting from acetazolamide is significantly enhanced for 123I(IMP), which could have diagnostic implications.
authors.affiliation: AEC Institute for Life Sciences, University of Pretoria, South Africa.
authors.forename: I C
authors.initials: IC
authors.lastname: Dormehl
authors.forename: D W
authors.initials: DW
authors.lastname: Oliver
authors.forename: N
authors.initials: N
authors.lastname: Hugo
authors.forename: D
authors.initials: D
authors.lastname: Rossouw
mesh_terms: D000086:Acetazolamide / Q000494:pharmacology*; D000662:Amphetamines / Q000493:pharmacokinetics*; D000818:Animals; D001921:Brain / Q000000981:diagnostic imaging* / Q000378:metabolism; D002560:Cerebrovascular Circulation / Q000187:drug effects*; D004347:Drug Interactions; D008297:Male; D010091:Oximes / Q000493:pharmacokinetics*; D010215:Papio; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000662:Amphetamines; D010091:Oximes; C068296:hexamethylpropyleneamine oxime; C041336:4-iodoamphetamine; D000086:Acetazolamide