title: Frequency encoding in excitable systems with applications to calcium oscillations.
abstract: A number of excitable cell types respond to a constant hormonal stimulus with a periodic oscillation in intracellular calcium. The frequency of oscillation is often proportional to the hormonal stimulus, and one says that the stimulus is frequency encoded. Here we develop a theory of frequency encoding in excitable systems and apply it to intracellular calcium oscillations that results from increases in the intracellular level of inositol 1,4,5-triphosphate.
authors.affiliation: Department of Physiology and Biophysics, Cornell University Medical College, New York, NY 10021, USA.
authors.forename: Y
authors.initials: Y
authors.lastname: Tang
authors.forename: H G
authors.initials: HG
authors.lastname: Othmer
mesh_terms: D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003593:Cytoplasm / Q000378:metabolism; D015544:Inositol 1,4,5-Trisphosphate / Q000378:metabolism; D007700:Kinetics; D008433:Mathematics; D008954:Models, Biological; D009991:Oscillometry; D015290:Second Messenger Systems; D013997:Time Factors
chemical_list: D015544:Inositol 1,4,5-Trisphosphate; D002118:Calcium