Genes encoding human serum amyloid A proteins SAA1 and SAA2 are located 18 kb apart in opposite transcriptional orientations.
The three expressed genes of the human serum amyloid A gene family (SAA1, SAA2 and SAA4) have been isolated in four contiguous clones selected from a chromosome 11 cosmid library. Analysis of these clones revealed that SAA1 and SAA2 are located 18 kb apart in opposite transcriptional orientations, while SAA4 lies 11 kb downstream from SAA2 in the same orientation: 3'(SAA1)5'-18 kb-5'(SAA2)3'-11 kb-5'(SAA4)3'. A fifth SAA clone isolated from this library was noncontiguous with the other four and contained the SAA3 pseudogene.
Kluve-Beckerman
B
B
Department of Medicine, Indiana University School of Medicine, Indianapolis 46202, USA.
Song
M
M
D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D015698:Genomic Library; D006801:Humans; D005810:Multigene Family / Q000235:genetics*; D011544:Pseudogenes / Q000235:genetics; D015183:Restriction Mapping; D000685:Serum Amyloid A Protein / Q000235:genetics*; D014158:Transcription, Genetic
C083772:SAA2 protein, human; C094771:SAA4 protein, human; D000685:Serum Amyloid A Protein