Importance of endoscopically visualized recurrent ileitis and small-bowel resection for symptoms in Crohn's disease.
BACKGROUND
The relationship between the endoscopic appearance of the ileal mucosa in Crohn's disease and the symptoms has not been studied. Although surgery is important, morbidity caused by intestinal resections and its relation to recurrent inflammation have been poorly evaluated.


METHODS
The relationship of symptoms to various ileoscopic signs of inflammation and previous intestinal resection was prospectively studied in 75 postresection Crohn patients.


RESULTS
Multivariate analysis showed that a combination of anastomotic width, pus, and length of previous small-bowel resection best explained a symptom score (r = 0.53, p < 0.001). Of 40 patients with the anastomosis strictured to less than 15 mm, only 9 had moderate to severe symptoms. Patients with a stricture diameter < 10 mm differed significantly in symptom score (p < 0.05) from those with wider anastomoses.


CONCLUSIONS
The study indicated that intestinal resection was as important for symptoms as endoscopically viewed recurrent ileal inflammation. The diameter at which an intestinal stricture produces symptoms is less than previously argued, and the association of small-bowel resection with symptoms underlines the advisability of minimal surgery.
Smedh
K
K
Dept. of Medico-Surgical Gastroenterology, University Hospital, Linköping, Sweden.
Olaison
G
G
Sjödahl
R
R
D000328:Adult; D003106:Colon / Q000601:surgery; D003424:Crohn Disease / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D016099:Endoscopy, Gastrointestinal; D005260:Female; D006801:Humans; D007082:Ileum / Q000473:pathology* / Q000601:surgery; D007413:Intestinal Mucosa / Q000473:pathology*; D008297:Male; D011183:Postoperative Complications / Q000473:pathology*; D011446:Prospective Studies; D012008:Recurrence