New antibiotics phthoxazolins B, C and D produced by Streptomyces sp. KO-7888.
New antibiotics, phthoxazolins B, C and D were isolated from the fermentation broth of Streptomyces sp. KO-7888. They are geometrical isomers of 10-hydroxyphthoxazolin A. They showed selective antifungal activity against Phytophthora parasitica in vitro and modest herbicidal activity in a laboratory test, but the potencies were different among isomers.
Shiomi
K
K
Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
Arai
N
N
Shinose
M
M
Takahashi
Y
Y
Yoshida
H
H
Iwabuchi
J
J
Tanaka
Y
Y
Omura
S
S
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006540:Herbicides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces; D013329:Structure-Activity Relationship
C095349:10-hydroxyphthoxazolin A; D000935:Antifungal Agents; D005233:Fatty Alcohols; D006540:Herbicides; D010080:Oxazoles