Effect of transdermal hyoscine on nausea and vomiting after surgical correction of prominent ears under general anaesthesia.
In a double-blind, randomized study, we have compared the efficacy of transdermal hyoscine with placebo in the reduction of nausea and vomiting in 50 patients, ASA I-II, after surgical correction of prominent ears under general anaesthesia. In the placebo group, 28%, 4% and 48% of patients suffered nausea, retching and vomiting, respectively, during the first 24 h after anaesthesia. The corresponding values in the hyoscine group were 12%, 0% and 16% (P < 0.01). In the placebo group more patients (48%) needed droperidol as an antiemetic compared with the hyoscine group (16%; P < 0.05). There was significantly more sedation in the hyoscine group.
Honkavaara
P
P
Department of Anaesthesia, University of Helsinki, Finland.
Saarnivaara
L
L
Klemola
U M
UM
D000279:Administration, Cutaneous; D000293:Adolescent; D000328:Adult; D000768:Anesthesia, General; D002648:Child; D004311:Double-Blind Method; D004431:Ear, External / Q000002:abnormalities / Q000601:surgery*; D005260:Female; D006801:Humans; D008297:Male; D009325:Nausea / Q000517:prevention & control*; D011183:Postoperative Complications / Q000517:prevention & control*; D012601:Scopolamine / Q000008:administration & dosage*; D013997:Time Factors; D014839:Vomiting / Q000517:prevention & control*
D012601:Scopolamine