title: Folliculostatins, gonadotropins and a model for control of growth in the grey fleshfly, Neobellieria (sarcophaga) bullata.
abstract: The sequences of two folliculostatic peptides of the fleshfly Neobellieria bullata have been determined recently. The first peptide (Neb-TMOF: H-NPTNLH-OH), originates from a 75 kDa precursor protein found in vitellogenic oocytes. The hexapeptide directly inhibits the synthesis of trypsin-like enzymes in the gut, and thus lowers the concentration of yolk polypeptides in the hemolymph. It also inhibits the biosynthesis of ecdysone in the larval ring gland. Therefore, it could also be named prothoracicostatic hormone (Neb-PTSH). The second peptide (Neb-colloostatin: H-SIV-PLGLPVPIGPIVVGPR-OH) acts on previtellogenic follicles and is a cleaved product of a collagen-like precursor molecule. Our results indicate that peptides that are cleaved from matrix proteins could act as growth-inhibiting factors. Gonadotropin releasing hormone (GnRH)-immunolike peptides were not identified, but progress is being made in the isolation and characterization of factors which stimulate cAMP production by the ovary. Using these results, a novel model of growth control in which matrix proteins play an important role as a potential source of growth regulators has been developed.
authors.affiliation: Zoological Institute of the University, Leuven, Belgium.
authors.forename: A
authors.initials: A
authors.lastname: De Loof
authors.forename: D
authors.initials: D
authors.lastname: Bylemans
authors.forename: L
authors.initials: L
authors.lastname: Schoofs
authors.forename: I
authors.initials: I
authors.lastname: Janssen
authors.forename: K
authors.initials: K
authors.lastname: Spittaels
authors.forename: J
authors.initials: J
authors.lastname: Vanden Broeck
authors.forename: R
authors.initials: R
authors.lastname: Huybrechts
authors.forename: D
authors.initials: D
authors.lastname: Borovsky
authors.forename: Y J
authors.initials: YJ
authors.lastname: Hua
authors.forename: J
authors.initials: J
authors.lastname: Koolman
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D004175:Diptera / Q000254:growth & development* / Q000502:physiology; D005260:Female; D006062:Gonadotropins / Q000502:physiology*; D007265:Inhibins / Q000502:physiology*; D007301:Insect Hormones / Q000737:chemistry / Q000502:physiology*; D019476:Insect Proteins; D007814:Larva / Q000254:growth & development; D008297:Male; D008956:Models, Chemical; D008969:Molecular Sequence Data; D009419:Nerve Tissue Proteins / Q000502:physiology; D009842:Oligopeptides / Q000502:physiology; D014818:Vitellogenesis
chemical_list: D006062:Gonadotropins; D007301:Insect Hormones; D019476:Insect Proteins; C094892:Neb-colloostatin; D009419:Nerve Tissue Proteins; D009842:Oligopeptides; C094891:prothoracicostatic hormone, Neobellieria bullata; C072215:ovary maturating parsin protein, Locusta migratoria; D007265:Inhibins