Synthesis of some N,N-disubstituted carbamodithioic acid esters tested for antifungal activity.
The synthesis of 12 new 4-[(N,N-disubstituted thiocarbamoylthio)acetamido]antipyrines and their antifungal activity are reported. Of these compounds, only 3e, showed good antifungal activity against C. tropicalis KUEN 1021, C. krusei KUEN 1001, C. stellatoidea KUEN 1018, C. pseudotropicalis KUEN 1012, C. albicans ATCC 10231 when compared with clotrimazole and miconazole (MIC = 12.5 micrograms/ml).
Ates
O
O
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Turkey.
Cesur
N
N
Güner
H
H
Uzun
M
M
Kiraz
M
M
Kaya
D
D
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D000983:Antipyrine / Q000031:analogs & derivatives / Q000138:chemical synthesis / Q000494:pharmacology*; D015394:Molecular Structure
D000935:Antifungal Agents; D000983:Antipyrine