title: Comparison of Edmonston-Zagreb, Connaught and Schwarz measles vaccines in Cameroonian infants aged 3-8 months.
abstract: Eighty-five Cameroonian infants aged between 3 and 8 months were vaccinated with a high-dose Edmonston-Zagreb (EZ) strain (10(5.6) TDIC50), 81 with a low-dose Connaught strain (10(3) TCID50) and 74 with a medium-dose Schwarz strain (10(4) TCID50). Side-effects were mild (less than 32% of infants) and were not significantly different among the groups, nor were postvaccination anti-measles antibody levels. Postvaccination seropositivity and seroconversion rates were respectively 91.6% and 69% for EZ, 85.3% and 67.7% for Connaught and 75.6% and 62.2% for Schwarz. In the light of concerns regarding high-titre measles vaccines, the overall performance of the Connaught strain warrants its wider evaluation in young infants.
authors.affiliation: Faculty of Medicine and Biomedical Sciences, University of Yaounde I, Cameroon.
authors.forename: P M
authors.initials: PM
authors.lastname: Ndumbe
authors.forename: S A
authors.initials: SA
authors.lastname: Gilchrist
authors.forename: H
authors.initials: H
authors.lastname: Pabst
authors.forename: M T
authors.initials: MT
authors.lastname: Sama
authors.forename: J
authors.initials: J
authors.lastname: Mbede
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007074:Immunoglobulin G / Q000097:blood; D007223:Infant; D008457:Measles / Q000097:blood / Q000276:immunology / Q000517:prevention & control*; D008458:Measles Vaccine / Q000009:adverse effects
chemical_list: D000914:Antibodies, Viral; D007074:Immunoglobulin G; D008458:Measles Vaccine