The novel desmethyldestruxin B2, from Metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells.
We have examined the antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B2 [1], was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.
Chen
H
H
Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan.
Yeh
S F
SF
Ong
G T
GT
Wu
S H
SH
Sun
C M
CM
Chou
C K
CK
D000818:Animals; D003470:Culture Media; D006514:Hepatitis B Surface Antigens / Q000096:biosynthesis*; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D003470:Culture Media; D006514:Hepatitis B Surface Antigens; D010456:Peptides, Cyclic; C094783:desmethyldestruxin B2