title: Cell-cycle checkpoints. Keeping mitosis in check.
abstract: Mutations in an essential yeast gene, encoding DNA polymerase epsilon, abolish the dependence of mitosis on the completion of DNA replication, suggesting that the replication complex provides the checkpoint signal.
authors.affiliation: Department of Genetics, Harvard Medical School, Boston, Massachusetts 02115, USA.
authors.forename: T
authors.initials: T
authors.lastname: Humphrey
authors.forename: T
authors.initials: T
authors.lastname: Enoch
mesh_terms: D000818:Animals; D004257:DNA Polymerase II; D004261:DNA Replication / Q000502:physiology*; D004259:DNA-Directed DNA Polymerase / Q000235:genetics / Q000378:metabolism*; D006801:Humans; D008938:Mitosis / Q000502:physiology*; D009154:Mutation; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000502:physiology; D012568:Schizosaccharomyces / Q000235:genetics / Q000502:physiology
chemical_list: D004257:DNA Polymerase II; D004259:DNA-Directed DNA Polymerase