Evidence for a susceptibility locus for schizophrenia on chromosome 6pter-p22.
We have performed linkage analysis in 186 multiplex families to search for genes that predispose to schizophrenia. Under a model with partially dominant inheritance, moderately broad disease definition and assuming locus homogeneity, a lod score of 3.2 was obtained for D6S260 on chromosome 6p23. A multipoint lod score of 3.9 (P = 2.3 x 10(-5)) was achieved when the F13A1 and D6S260 loci were analysed, allowing for locus heterogeneity. Adjusted for testing of multiple models, the multipoint lod score of 3.9 under heterogeneity has a genome wide significance of between 5-8%. The nonparametric affected pedigree member test provided results (P = 3 x 10(-4)) also supporting this finding. Our findings provide supportive evidence for a susceptibility locus for schizophrenia on distal chromosome 6p, and support a model of locus heterogeneity.
Wang
S
S
Molecular Epidemiology and Disease Indicators Branch, NIDR, Bethesda, Maryland 20892, USA.
Sun
C E
CE
Walczak
C A
CA
Ziegle
J S
JS
Kipps
B R
BR
Goldin
L R
LR
Diehl
S R
SR
D002896:Chromosomes, Human, Pair 6; D004276:DNA, Satellite; D005260:Female; D018740:Genetic Heterogeneity; D008040:Genetic Linkage; D005819:Genetic Markers; D006801:Humans; D008126:Lod Score; D008297:Male; D012559:Schizophrenia / Q000235:genetics*
D004276:DNA, Satellite; D005819:Genetic Markers