title: Effects of low-copper diets on human immune response.
abstract: We examined the effects of low-copper diets on indexes of immune response of 11 healthy men (aged 21-32 y) during a 90-d metabolic suite study. Daily copper intake for the first 24 d, next 42 d, and the last 24 d of the study was 0.66, 0.38, and 2.49 mg, respectively. Feeding the diet with 0.38 mg Cu/d was associated with a significant (P < or = 0.05) decrease in the proliferation of peripheral blood mononuclear cells cultured with phytohemagglutinin, Concanavalin A, or pokeweed, and an increase in the percentage of circulating B cells (CD 19+), but had no effect on the concentration of serum interleukin 2 receptor, the percentage of peripheral monocytes, neutrophils, CD3+, CD4+, or CD8+ T cells; or on the neutrophil phagocytic activity. Feeding 2.49 mg Cu/d for 24 d prevented further decreases in the indexes affected by the low-copper diet but did not restore them to the prestudy concentrations, even though plasma copper and ceruloplasmin concentrations were restored to normal.
authors.affiliation: United States Department of Agriculture, Agricultural Research Service, Presidio of San Francisco, CA 94129, USA.
authors.forename: D S
authors.initials: DS
authors.lastname: Kelley
authors.forename: P A
authors.initials: PA
authors.lastname: Daudu
authors.forename: P C
authors.initials: PC
authors.lastname: Taylor
authors.forename: B E
authors.initials: BE
authors.lastname: Mackey
authors.forename: J R
authors.initials: JR
authors.lastname: Turnlund
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D001772:Blood Cell Count; D016022:Case-Control Studies; D002570:Ceruloplasmin / Q000032:analysis; D003208:Concanavalin A / Q000494:pharmacology; D003300:Copper / Q000008:administration & dosage / Q000097:blood / Q000494:pharmacology*; D004032:Diet; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007107:Immune System / Q000187:drug effects* / Q000502:physiology; D007111:Immunity, Cellular / Q000187:drug effects*; D016014:Linear Models; D008213:Lymphocyte Activation / Q000187:drug effects; D008297:Male; D009000:Monocytes / Q000166:cytology / Q000187:drug effects; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D010587:Phagocytosis / Q000187:drug effects / Q000502:physiology; D011043:Pokeweed Mitogens / Q000494:pharmacology; D015375:Receptors, Interleukin-2 / Q000032:analysis
chemical_list: D011043:Pokeweed Mitogens; D015375:Receptors, Interleukin-2; D003208:Concanavalin A; D003300:Copper; D002570:Ceruloplasmin