Intraperitoneal erythropoietin treatment of children with chronic renal failure.
Intraperitoneal erythropoietin was given to three children on chronic peritoneal dialysis. Doses between 100 and 150 units/kg were given undiluted into a dry cavity twice weekly and left for 10-12 h before resuming dialysis. Satisfactory haemoglobin levels were seen over a 6-month period and there were no complications. Intraperitoneal administration of erythropoietin is cost-effective and avoids the local pain of subcutaneous injections.
Steele
B T
BT
Department of Paediatrics, McMaster University Medical Centre, Hamilton, Ontario, Canada.
Vigneux
A
A
D000740:Anemia / Q000188:drug therapy* / Q000209:etiology; D002648:Child; D004921:Erythropoietin / Q000008:administration & dosage* / Q000493:pharmacokinetics; D005260:Female; D006454:Hemoglobins / Q000187:drug effects; D006801:Humans; D007223:Infant; D007274:Injections, Intraperitoneal; D007676:Kidney Failure, Chronic / Q000150:complications* / Q000188:drug therapy; D008297:Male; D010530:Peritoneal Dialysis; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000493:pharmacokinetics
D006454:Hemoglobins; D011994:Recombinant Proteins; D004921:Erythropoietin