title: Open flow microperfusion: approach to in vivo glucose monitoring.
abstract: A slow flow of liquid over the working tip of a classical glucose needle electrode allows a significant reduction in surface fouling with minimal sample dilution. The fluid flow technique enables relatively drift-free in vivo operation for up to four hours (electrode responses in vitro following explanation of the device after a 4 h monitoring period are within +/- 5% of original values), exhibits a close correlation with blood glucose levels and is unique in requiring no in vivo calibration.
authors.affiliation: University of Manchester, Department of Medicine/Clinical Biochemistry, Salford, UK.
authors.forename: G P
authors.initials: GP
authors.lastname: Rigby
authors.forename: P
authors.initials: P
authors.lastname: Crump
authors.forename: P
authors.initials: P
authors.lastname: Vadgama
mesh_terms: D000818:Animals; D015374:Biosensing Techniques; D001786:Blood Glucose / Q000378:metabolism*; D002138:Calibration; D008991:Monitoring, Physiologic / Q000379:methods; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D001786:Blood Glucose