Involvement of the 4q21 region in human malignant melanomas: cytogenetic and immunocytochemical characterization of three primary cell cultures.
The GRO1 oncogene (melanoma growth-stimulating activity alpha) has been localized in region 4q21. The involvement of this chromosomal region in clonal aberrations found in primary melanoma cell cultures could have an important role in the etiology and pathogenesis of this tumor. We characterized three primary cell cultures obtained from different patients, each of which showed clonal chromosomal aberrations involving the 4q21 region.
Grammatico
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P
Cattedra di Genetica Medica, Università La Sapienza, Rome, Italy.
Roccella
M
M
Catricalà
C
C
Roccella
F
F
Bucher
S
S
Mordenti
C
C
Amantea
A
A
Di Rosa
C
C
Del Porto
G
G
D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D002630:Chemotactic Factors / Q000235:genetics; D002869:Chromosome Aberrations; D002894:Chromosomes, Human, Pair 4; D003582:Cytogenetics; D006133:Growth Substances / Q000235:genetics; D006801:Humans; D007124:Immunoenzyme Techniques; D036341:Intercellular Signaling Peptides and Proteins; D008545:Melanoma / Q000737:chemistry / Q000235:genetics*; D009363:Neoplasm Proteins / Q000235:genetics; D012878:Skin Neoplasms / Q000737:chemistry / Q000235:genetics*; D014407:Tumor Cells, Cultured
C475829:CXCL1 protein, human; D054360:Chemokine CXCL1; D019743:Chemokines, CXC; D002630:Chemotactic Factors; D006133:Growth Substances; D036341:Intercellular Signaling Peptides and Proteins; D009363:Neoplasm Proteins