title: Regulation of extracellular toxin production in Clostridium perfringens.
abstract: Until recently, little was known about the regulation of toxin production in Clostridium perfringens. Three regulatory genes that control the production of theta toxin (perfringolysin O) have now been identified. Two of these genes make up a two-component sensor-kinase-response-regulator system that also controls the production of other extracellular toxins.
authors.affiliation: Dept of Microbiology, Monash University, Clayton, Australia.
authors.forename: J I
authors.initials: JI
authors.lastname: Rood
authors.forename: M
authors.initials: M
authors.lastname: Lyristis
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics; D001427:Bacterial Toxins / Q000096:biosynthesis*; D003016:Clostridium perfringens / Q000235:genetics* / Q000378:metabolism; D015964:Gene Expression Regulation, Bacterial; D005809:Genes, Regulator / Q000502:physiology; D006460:Hemolysin Proteins; D008957:Models, Genetic; D010738:Type C Phospholipases / Q000235:genetics
chemical_list: D001426:Bacterial Proteins; D001427:Bacterial Toxins; D006460:Hemolysin Proteins; C068267:mry protein, Streptococcus pyogenes; C020452:Clostridium perfringens theta-toxin; D010738:Type C Phospholipases