title: Influence of hydration state on plasma volume changes during ultrafiltration.
abstract: To assess the influence of hydration state on plasma volume (PV) changes during ultrafiltration, 11 clinically normhydrated patients on maintenance hemodialysis were studied intraindividually during 2 hydration states differing by 2-15% of lean body mass (LBM). Plasma volume was measured continually during a 15-min ultrafiltration test including an ultrafiltration of 1% of target weight and during a 45-min follow-up period of blood recirculation through the dialyzer without ultrafiltration. In all patients a maximal decrease in relative PV was more pronounced when there was less hydration and when the grade of hydration correlated inversely with the maximal response of PV decrease (r = -0.68, p < 0.001). The same was observed between the hydration state and the slope of the PV decrease (r = -0.69, p < 0.001). Plasma refilling was estimated in the period following ultrafiltration. The slope of the plasma volume increase correlated with the grade of hydration (r = 0.31, p < 0.05) as did the asymtote of PV (r = 0.4, p < 0.01). It is concluded that the less hydrated a dialysis patient is, the more pronounced will be the fall of the ultrafiltration-induced plasma volume and the less distinct will be the recovery of the plasma volume after the discontinuation of ultrafiltration.
authors.affiliation: Georg Haas Dialysis Center, Giessen, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Wizemann
authors.forename: A
authors.initials: A
authors.lastname: Leibinger
authors.forename: K
authors.initials: K
authors.lastname: Mueller
authors.forename: A
authors.initials: A
authors.lastname: Nilson
mesh_terms: D000328:Adult; D001824:Body Constitution; D001834:Body Water / Q000502:physiology*; D001835:Body Weight; D005260:Female; D005500:Follow-Up Studies; D006440:Hemofiltration; D006801:Humans; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal; D010953:Plasma Volume; D006435:Renal Dialysis; D014462:Ultrafiltration