Thiazinotrienomycins, new ansamycin group antibiotics.
New triene-ansamycins designated thiazinotrienomycins A, B, C, D and E were isolated from culture broth of Streptomyces sp. MJ672-m3 for their activities against cervical cancer cell lines. The structures and some biological and biochemical properties of the antibiotics were determined.
Hosokawa
N
N
Institute of Microbial Chemistry, Tokyo, Japan.
Naganawa
H
H
Inuma
H
H
Hamada
M
M
Takeuchi
T
T
Kanbe
T
T
Hori
M
M
D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000627:therapeutic use; D002851:Chromatography, High Pressure Liquid; D005260:Female; D006367:HeLa Cells / Q000187:drug effects; D006801:Humans; D047029:Lactams, Macrocyclic; D007928:Lethal Dose 50; D051379:Mice; D015394:Molecular Structure; D013302:Streptomyces; D013329:Structure-Activity Relationship; D013843:Thiazines / Q000737:chemistry / Q000302:isolation & purification / Q000627:therapeutic use; D014407:Tumor Cells, Cultured / Q000187:drug effects; D002583:Uterine Cervical Neoplasms / Q000188:drug therapy
D000900:Anti-Bacterial Agents; D047029:Lactams, Macrocyclic; D013843:Thiazines; C094825:thiazinotrienomycin A; C094826:thiazinotrienomycin B; C094827:thiazinotrienomycin C; C094828:thiazinotrienomycin D; C094829:thiazinotrienomycin E