title: Early tolerance of different organs to fast fractionation in clinical practice.
abstract: OBJECTIVE
  To assess the feasibility of accelerated hyperfractionated radiotherapy in the treatment of breast, abdominal cavity, and pelvic tumors.
  
  
  METHODS
  Between August 1989 and March 1993, 39 patients were treated in Portsmouth by an accelerated, hyperfractionated regimen giving 45 to 54 Gy three times a day over 12 days. Twenty patients had abdominal cavity or pelvic tumors and 19 patients breast carcinoma, 9 of whom were treated prophylactically after local excision.
  
  
  RESULTS
  No local recurrence has been observed in the 19 patients with breast carcinoma, and out of the 20 with abdominal or pelvic tumors, 6 showed complete regression and so far no severe late damage has been observed. In those patients who had pelvic or abdominal tumors treated, the acute toxicity varied widely from minimal to very intensive. No surgical intervention was necessary and most reactions settled within a 6-week period.
  
  
  CONCLUSIONS
  Accelerated fractionation by small increments is well tolerated by the breast, pelvic, and abdominal organs.
authors.affiliation: Department of Radiotherapy and Oncology, Saint Mary's Hospital, Portsmouth, UK.
authors.forename: J
authors.initials: J
authors.lastname: Kovarik
authors.forename: V H
authors.initials: VH
authors.lastname: Svoboda
mesh_terms: D000008:Abdominal Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D001940:Breast / Q000528:radiation effects; D001943:Breast Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D005240:Feasibility Studies; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D009367:Neoplasm Staging; D010386:Pelvic Neoplasms / Q000473:pathology / Q000532:radiotherapy*; D011878:Radiotherapy / Q000009:adverse effects / Q000379:methods*; D011879:Radiotherapy Dosage