title: Murine model of anterior and posterior ocular melanoma.
abstract: Iris melanomas are less likely to metastasize than ciliary body or choroidal melanomas. In order to study this difference in metastatic rate, we developed a murine model of anterior chamber (AC) and posterior compartment (PC) melanoma. Eighteen C57BL6 mice were inoculated in the AC (n = 6) or PC (n = 12) with B16F10 melanoma cells and eleven mice were inoculated in the AC (n = 3) or PC (n = 8) with Queens melanoma cells. The animals were sacrificed at 12 to 14 days post inoculation and histologically examined. Results were that 8 of 9 AC tumors and 10 of 20 PC tumors grew. One PC tumor metastasized to the lungs. This model may be used to study anterior versus posterior ocular melanoma differences.
authors.affiliation: Department of Ophthalmology, Emory University School of Medicine, Atlanta, GA 30322, USA.
authors.forename: H E
authors.initials: HE
authors.lastname: Grossniklaus
authors.forename: B C
authors.initials: BC
authors.lastname: Barron
authors.forename: M W
authors.initials: MW
authors.lastname: Wilson
mesh_terms: D000818:Animals; D000867:Anterior Chamber; D002830:Choroid Neoplasms / Q000473:pathology*; D002924:Ciliary Body / Q000473:pathology*; D004195:Disease Models, Animal; D005260:Female; D015811:Iris Neoplasms / Q000473:pathology*; D008175:Lung Neoplasms / Q000556:secondary*; D008546:Melanoma, Experimental / Q000473:pathology / Q000556:secondary*; D051379:Mice; D008810:Mice, Inbred C57BL; D014604:Uveal Neoplasms / Q000473:pathology*