title: Spontaneous early improvement following ischemic stroke.
abstract: OBJECTIVE
  Recognizing that early spontaneous neurological improvement not uncommonly follows acute ischemic stroke, we conducted this study to determine the incidence of such improvement and its potential relation to stroke etiology.
  
  
  METHODS
  We prospectively evaluated 68 patients who presented within 12 hours after ischemic stroke, exhibited moderate or severe new functional neurological deficit acutely, and received either no stroke-specific therapy or only antiplatelet therapy over the ensuring week. We reexamined all patients 1 week after stroke onset.
  
  
  RESULTS
  Sixteen (24%) of the 68 patients improved to the point of having no or mild functional neurological deficit at 1 week. Patients with lacunar stroke were more likely to enjoy early spontaneous improvement (8/22 = 36% versus 8/46 = 17%), but this difference did not reach statistical significance (P = .15).
  
  
  CONCLUSIONS
  Early spontaneous improvement after ischemic stroke may occur in a substantial proportion of patients and more commonly after lacunar stroke. Even so, the majority of patients with acutely disabling stroke will remain significantly impaired 1 week after stroke onset.
authors.affiliation: Department of Neurology, University of South Alabama, Mobile 36617, USA.
authors.forename: J F
authors.initials: JF
authors.lastname: Rothrock
authors.forename: W M
authors.initials: WM
authors.lastname: Clark
authors.forename: P D
authors.initials: PD
authors.lastname: Lyden
mesh_terms: D002561:Cerebrovascular Disorders / Q000188:drug therapy / Q000209:etiology* / Q000473:pathology*; D006801:Humans; D010975:Platelet Aggregation Inhibitors / Q000627:therapeutic use; D011379:Prognosis; D011446:Prospective Studies; D013997:Time Factors
chemical_list: D010975:Platelet Aggregation Inhibitors