Antibody to annexin V has anti-phospholipid and lupus anticoagulant properties.
Anti-annexin V (anti-ANXV) IgG and lupus anticoagulant (LAC) were both shown to be capable of inducing apoptosis in umbilical vein endothelial cells [Nakamura et al.: Biochem Biophys Res Commun 205:1488-1493, 1994]. In the present study, we have demonstrated that anti-ANXV IgG prolongs the activated partial thromboplastin time and has an affinity for phospholipids in enzyme-linked immunosorbent assay. This indicates overlapping of anti-ANXV and LAC activities, suggesting that ANXV may be involved in the autoimmune mechanism for LAC production.
Nakamura
N
N
Department of Molecular Medicine, Osaka Medical Center, Japan.
Kuragaki
C
C
Shidara
Y
Y
Yamaji
K
K
Wada
Y
Y
D000818:Animals; D017304:Annexin A5 / Q000276:immunology*; D000906:Antibodies / Q000276:immunology / Q000378:metabolism / Q000494:pharmacology*; D017152:Antibodies, Antiphospholipid / Q000276:immunology / Q000378:metabolism*; D004797:Enzyme-Linked Immunosorbent Assay; D006801:Humans; D016682:Lupus Coagulation Inhibitor / Q000276:immunology / Q000378:metabolism*; D011817:Rabbits
D017304:Annexin A5; D000906:Antibodies; D017152:Antibodies, Antiphospholipid; D016682:Lupus Coagulation Inhibitor