Non-specific systemic immune suppression induced by photodynamic treatment of lymph node cells with bacteriochlorin a.
Although photodynamic therapy is being used increasingly for the treatment of cancer, its effect on immune responses has received little attention. This aspect was studied in a rat model. Rats were given (intravenously) lymph node cells which were simultaneously exposed to a photosensitizer and light. As a result of this treatment the animals showed a decreased contact hypersensitivity response. Most important is that the generated immunosuppression proved to be non-specific. The consequence of this finding may be that photodynamic therapy of tumours can inhibit the immune response against malignant cells.
van Iperen
H P
HP
Leiden/Amsterdam Center for Drug Research, Department of Medicinal Photochemistry, Leiden University, Netherlands.
Schuitmaker
H J
HJ
Beijersbergen van Henegouwen
G M
GM
D000818:Animals; D003877:Dermatitis, Contact / Q000276:immunology; D004139:Dinitrofluorobenzene / Q000276:immunology; D007165:Immunosuppression Therapy; D008027:Light; D008198:Lymph Nodes / Q000187:drug effects* / Q000276:immunology / Q000528:radiation effects; D008297:Male; D010778:Photochemotherapy / Q000379:methods*; D017319:Photosensitizing Agents / Q000494:pharmacology*; D010853:Picryl Chloride / Q000276:immunology; D011166:Porphyrins / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013154:Spleen / Q000276:immunology
D017319:Photosensitizing Agents; D011166:Porphyrins; C065423:bacteriochlorin a; D004139:Dinitrofluorobenzene; D010853:Picryl Chloride