Sinus arrest after administration of intravenous metoclopramide.
BACKGROUND
Sinus arrest is a rare complication of metoclopramide administration.


METHODS
A 51-year-old woman developed Guillain-Barre syndrome and severe dysautonomia. Metoclopramide was administered for the treatment of gastroparesis. Sinus arrest followed drug administration on several occasions and on rechallenge.


CONCLUSIONS
After reviewing the literature and discussing possible etiologies for this unusual adverse drug reaction in this setting, we recommend that metoclopramide be used with caution in patients prone to develop bradyarrythmias, particularly those with dysautonomias and Guillain-Barre syndrome.
Malkoff
M D
MD
Saint Louis University Medical Center, Department of Neurology, MO 63110, USA.
Ponzillo
J J
JJ
Myles
G L
GL
Gomez
C R
CR
Cruz-Flores
S
S
D001146:Arrhythmia, Sinus / Q000139:chemically induced*; D001342:Autonomic Nervous System Diseases / Q000150:complications*; D005260:Female; D018589:Gastroparesis / Q000150:complications / Q000188:drug therapy; D006801:Humans; D007275:Injections, Intravenous; D008787:Metoclopramide / Q000008:administration & dosage / Q000009:adverse effects*; D008875:Middle Aged; D010291:Paresis / Q000150:complications; D011129:Polyradiculoneuropathy / Q000150:complications* / Q000188:drug therapy
D008787:Metoclopramide