title: [Infections in cancer patients with granulocytopenia. Retrospective studies of 59 febrile episodes with hospitalization].
abstract: A total of 59 febrile neutropenic episodes were retrospectively recorded at Hôtel-Dieu de France Hospital between August 1st 1991 and December 31st 1992. These episodes were recorded in 51 cancer patients. Median neutropenia was less than one week in 50% of the cases. The etiology of these fever was documented in 27 episodes (46%) and in 70% of the cases gram (-) rods were documented. B-Lactam and Aminoglycoside antibiotics were used in 34 episodes at the initial treatment of these patients. Success rate at this initial treatment or with a modification of the antibiotic therapy was recorded in 85% of the patients. Only 15% of the patients failed to this antibiotherapy, 2/3 of them had their disease in progression. The systemic use of Amphotericine E in those patients with prolonged febrile neutropenia and the concommitent use of growth factors in a sub-group of patients at high risk could lead to a higher success rate in these patients.
authors.affiliation: Service d'Hématologie-Oncologie, Hôtel-Dieu de France, Beyrouth, Liban.
authors.forename: M
authors.initials: M
authors.lastname: Ghosn
authors.forename: E
authors.initials: E
authors.lastname: Dagher
authors.forename: F
authors.initials: F
authors.lastname: Nasr
authors.forename: G
authors.initials: G
authors.lastname: Chahine
authors.forename: N
authors.initials: N
authors.lastname: Taleb
authors.forename: R
authors.initials: R
authors.lastname: Nasnas
authors.forename: E
authors.initials: E
authors.lastname: Ghayad
mesh_terms: D000328:Adult; D000380:Agranulocytosis / Q000150:complications*; D000666:Amphotericin B / Q000627:therapeutic use; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001419:Bacteria / Q000302:isolation & purification; D001424:Bacterial Infections / Q000188:drug therapy / Q000209:etiology* / Q000382:microbiology; D005260:Female; D005334:Fever / Q000209:etiology; D006760:Hospitalization; D006801:Humans; D008297:Male; D009369:Neoplasms / Q000150:complications*; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D000900:Anti-Bacterial Agents; D000666:Amphotericin B
vernacular_title: Infections chez les cancéreux granulocytopéniques. Etudes rétrospectives de 59 épisodes fébriles hospitalisés.