[Experimental study of the effectiveness of interleukin-1beta in radiation injury].
The experiments on mice exposed to radiation (6.5 Gy, LD 80/30) discovered that human recombinant interleukin-1 beta after administration on postradiation hour 1-3 increased the animals' survival by 40-70%. Interleukin-1 beta reduced leukopenia and enhanced the recovery of bone marrow cell elements. The use of the preparation as an early pathogenetic treatment of irradiation damage holds promise.
Legeza
V I
VI
Chigareva
N G
NG
Petkevich
N V
NV
Vasil'eva
T P
TP
Abdul'
Iu A
IuA
Boĭko
V N
VN
D000818:Animals; D006410:Hematopoiesis / Q000187:drug effects / Q000528:radiation effects*; D006801:Humans; D007375:Interleukin-1 / Q000627:therapeutic use*; D008297:Male; D051379:Mice; D011833:Radiation Injuries, Experimental / Q000097:blood / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000627:therapeutic use
D007375:Interleukin-1; D011994:Recombinant Proteins
Eksperimental'noe issledovanie éffektivnosti interleĭkina-1beta pri luchevom porazhenii.