Prevention of dry socket with clindamycin. A retrospective study.
Clindamycin and other agents were compared for efficacy in preventing the entity "dry socket." A total 765 patients were treated with clindamycin, per os, and 408 patients were treated with other antibiotics or were non-treated controls. All patients underwent surgical removal of impacted mandibular third molars. The incidence of dry socket in untreated control and in non-clindamycin antibiotic-treated patients varied from 15 to 31 percent, while in those patients receiving clindamycin, the incidence was 0.65 percent. The results demonstrate a remarkable effectiveness of clindamycin in reducing the incidence of dry socket following surgical removal of impacted mandibular third molar.
Kupfer
S R
SR
Brooklyn VA Medical Center, USA.
D000328:Adult; D000368:Aged; D001442:Bacteroides Infections / Q000517:prevention & control*; D002981:Clindamycin / Q000494:pharmacology / Q000627:therapeutic use*; D004368:Dry Socket / Q000382:microbiology / Q000517:prevention & control*; D005260:Female; D006801:Humans; D008034:Lincomycin / Q000627:therapeutic use; D008297:Male; D008875:Middle Aged; D008964:Molar, Third / Q000601:surgery*; D009583:Nitrofurazone / Q000627:therapeutic use; D010406:Penicillins / Q000627:therapeutic use; D001443:Prevotella melaninogenica / Q000187:drug effects; D012189:Retrospective Studies; D014081:Tooth Extraction
D010406:Penicillins; D002981:Clindamycin; C065221:penicillin K; D008034:Lincomycin; D009583:Nitrofurazone