title: MRI of the brain in Wilson disease: T2 signal loss under therapy.
abstract: Repeat examinations in a de novo patient with Wilson disease revealed an expansion of decreased signal intensities in the basal ganglia on T2-weighted imaging after initiation of copper trapping therapy. Since marked clinical improvement was associated with continued urinary copper excretion, iron depositioning in exchange for copper might explain these findings.
authors.affiliation: Institute of Diagnostic Radiology, Heinrich-Heine University of Düsseldorf, Germany.
authors.forename: V
authors.initials: V
authors.lastname: Engelbrecht
authors.forename: G
authors.initials: G
authors.lastname: Schlaug
authors.forename: H
authors.initials: H
authors.lastname: Hefter
authors.forename: T
authors.initials: T
authors.lastname: Kahn
authors.forename: U
authors.initials: U
authors.lastname: Mödder
mesh_terms: D000328:Adult; D001479:Basal Ganglia / Q000473:pathology; D001921:Brain / Q000473:pathology*; D005500:Follow-Up Studies; D006527:Hepatolenticular Degeneration / Q000188:drug therapy / Q000473:pathology*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D010396:Penicillamine / Q000627:therapeutic use; D013997:Time Factors
chemical_list: D010396:Penicillamine