title: Transretinal membrane formation in diffuse unilateral subacute neuroretinitis.
abstract: BACKGROUND
  Diffuse unilateral subacute neuroretinitis (DUSN) is characterized by unilateral visual loss with vitreous inflammation, optic disc swelling, and the presence of gray-white lesions in the deep retina, and can be associated with intraocular nematode infection. To date, no cases of transretinal membrane formation in DUSN have been reported.
  
  
  METHODS
  A 22-year-old woman was examined for a 2-week history of unilateral decreased vision and neuroretinitis. A subretinal nematode was identified and a diagnosis of DUSN was made. The nematode was destroyed with laser photocoagulation. An epiretinal membrane and traction retinal detachment persisted and the membrane was removed surgically, at which time it was noted to be transretinal, passing through a full-thickness retinal defect into the subretinal space. Laser photocoagulation was performed with the argon green laser (400 mW, 400 microns, 100 msec). Subsequent removal of the epiretinal portion of the transretinal membrane was performed via a pars plana approach. The membrane was studied by transmission electron microscopy (TEM).
  
  
  RESULTS
  The laser photocoagulation was successful in destroying the nematode. Partial resolution of the neurosensory detachment resulted in marked improvement in visual acuity. The membrane consisted of a pauicellular collagenous stroma with scattered fibroblasts and mononuclear inflammatory cells.
  
  
  CONCLUSIONS
  Removal of membranes affecting the macula may be of benefit in selected patients with DUSN.
authors.affiliation: Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110, USA.
authors.forename: B T
authors.initials: BT
authors.lastname: Matsumoto
authors.forename: D A
authors.initials: DA
authors.lastname: Adelberg
authors.forename: L V
authors.initials: LV
authors.lastname: Del Priore
mesh_terms: D000208:Acute Disease; D000328:Adult; D002462:Cell Membrane / Q000648:ultrastructure; D003131:Combined Modality Therapy; D015822:Eye Infections, Parasitic / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D005260:Female; D005654:Fundus Oculi; D006801:Humans; D017075:Laser Coagulation; D009349:Nematode Infections / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D009902:Optic Neuritis / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D012160:Retina / Q000648:ultrastructure*; D012163:Retinal Detachment / Q000209:etiology / Q000601:surgery; D012164:Retinal Diseases / Q000209:etiology / Q000473:pathology*; D012173:Retinitis / Q000188:drug therapy / Q000473:pathology* / Q000601:surgery; D013827:Thiabendazole / Q000627:therapeutic use; D014792:Visual Acuity
chemical_list: D013827:Thiabendazole