title: [Study of metabolism of T-3761 in animal].
abstract: The metabolism of T-3761 in mouse, rat, rabbit, dog and monkey was studied. Four metabolites, other than unchanged T-3761, were detected and identified as follows: T-3761 glucuronide; T-3761M1, adduct of glucose; T-3761M2 and T-3761M3, compounds metabolized at 1-aminocyclopropyl ring. In urine of mouse, T-3761 glucuronide was mainly detected, but in urine of other animals, T-3761 was mainly detected.
authors.affiliation: Research Laboratories, Toyama Chemical Co., Ltd.
authors.forename: M
authors.initials: M
authors.lastname: Tai
authors.forename: K
authors.initials: K
authors.lastname: Demachi
authors.forename: Y
authors.initials: Y
authors.lastname: Simizu
mesh_terms: D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000493:pharmacokinetics*; D004285:Dogs; D024841:Fluoroquinolones; D008252:Macaca fascicularis; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D010078:Oxazines / Q000008:administration & dosage / Q000493:pharmacokinetics*; D011817:Rabbits; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010078:Oxazines; C078052:pazufloxacin