title: [The present and future problems of resistance in staphylococci, streptococci and M. tuberculosis].
abstract: Mechanisms of resistance of strains of Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus pneumoniae, Enterococcus faecalis, Enterococcus faecium, Neisseria meningitidis and Mycobacterium tuberculosis to antibiotics are presented and discussed. The resistance to methicillin-oxacillin in S. aureus and S. epidermidis is chromosomally-mediated by sequence of DNA, namely by gene mecA. This gene codes altered PBP-2A protein. Strains of S.pneumoniae contain PBP-1A, PBP-2B and PBP-2X proteins. They cause resistance to many beta-lactam antibiotics. Resistance to vankomycin, respectively to teikoplanin in strains of E. faecalis and E. faecium is coded by transferable vanA and vanB genes. Strains of N. meningitidis produce mostly the altered PBP-2 protein. The increase of resistance in strains of M. tuberculosis is also significant.
authors.affiliation: Ustav preventívnej a klinickej medicíny v Bratislave, Slovakia.
authors.forename: M
authors.initials: M
authors.lastname: Hupková
authors.forename: J
authors.initials: J
authors.lastname: Blahavá
authors.forename: K
authors.initials: K
authors.lastname: Králiková
authors.forename: V
authors.initials: V
authors.lastname: Krcméry
mesh_terms: D004351:Drug Resistance; D018432:Drug Resistance, Multiple; D009169:Mycobacterium tuberculosis / Q000187:drug effects*; D013210:Staphylococcus / Q000187:drug effects*; D013291:Streptococcus / Q000187:drug effects*
vernacular_title: Súcasné a budúce problémy rezistencie stafylokokov, streptokokov a M.tuberculosis.