Fusacandins A and B; novel antifungal antibiotics of the papulacandin class from Fusarium sambucinum. I. Identity of the producing organism, fermentation and biological activity.
The fuscandins, antifungal agents of the papulacandin class, are produced by a strain of Fusarium sambucinum. Fermentation yielded 60 mg/liter of fusacandin A and minor amounts of fusacandin B. As expected, the fusacandins inhibit (1,3)-beta-glucan synthesis. Fusacandin A is slightly less active than papulacandin B against Candida albicans and, like papulacandin, loses activity in the presence of serum.
Jackson
M
M
Abbott Laboratories, Abbott Park, IL 60064, USA.
Frost
D J
DJ
Karwowski
J P
JP
Humphrey
P E
PE
Dahod
S K
SK
Choi
W S
WS
Brandt
K
K
Malmberg
L H
LH
Rasmussen
R R
RR
Scherr
M H
MH
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D000935:Antifungal Agents / Q000302:isolation & purification / Q000494:pharmacology*; D002176:Candida albicans / Q000187:drug effects; D005231:Fatty Acids, Unsaturated / Q000302:isolation & purification / Q000494:pharmacology; D005285:Fermentation; D005670:Fusarium; D008826:Microbial Sensitivity Tests; D009844:Oligosaccharides / Q000302:isolation & purification / Q000494:pharmacology
D000617:Aminoglycosides; D000900:Anti-Bacterial Agents; D000935:Antifungal Agents; D005231:Fatty Acids, Unsaturated; D009844:Oligosaccharides; C095339:fusacandin A; C095340:fusacandin B; C020789:papulacandin B