Weak immunogenicity of the preS2 sequence and lack of circumventing effect on the unresponsiveness to the hepatitis B virus vaccine.
The preS2 sequence is known to circumvent immunological unresponsiveness to the S protein and to induce a 'carrier' effect on the anti-S antibody production, in mice. In humans, an anti-S response was found in 100% and 97% of healthy subjects vaccinated with the S and S + preS2 preparations, respectively, whereas less than 50% of drinkers responded whatever the vaccine used. Anti-preS2 were found in 44% of healthy recipients of the S + preS2 vaccine, whereas there were no anti-preS2 responders in drinkers. Anti-preS2 remained undetectable in 32% of the blood donors hyperimmunized with the S + preS2 vaccine, whereas anti-S antibody boosted in all cases. In humans, in contrast to mice, immunogenicity of the preS2 sequence appears weak and the preS sequence does not circumvent the anti-S unresponsiveness.
Pillot
J
J
Hôpital Antoine Béclère, Service de Microbiologie et d'Immunologie, Clamart, France.
Poynard
T
T
Elias
A
A
Maillard
J
J
Lazizi
Y
Y
Brancer
M
M
Dubreuil
P
P
Budkowska
A
A
Chaput
J C
JC
D000328:Adult; D000428:Alcohol Drinking; D000914:Antibodies, Viral; D006510:Hepatitis B Antibodies / Q000096:biosynthesis; D006514:Hepatitis B Surface Antigens / Q000494:pharmacology*; D017325:Hepatitis B Vaccines / Q000276:immunology* / Q000494:pharmacology*; D006801:Humans; D011498:Protein Precursors / Q000494:pharmacology*; D012680:Sensitivity and Specificity; D014614:Vaccines, Synthetic / Q000276:immunology / Q000494:pharmacology; D014759:Viral Envelope Proteins / Q000494:pharmacology*
D000914:Antibodies, Viral; D006510:Hepatitis B Antibodies; D006514:Hepatitis B Surface Antigens; D017325:Hepatitis B Vaccines; D011498:Protein Precursors; D014614:Vaccines, Synthetic; D014759:Viral Envelope Proteins; C050807:presurface protein 2, hepatitis B surface antigen