title: Irradiation and fusion gene transfer.
abstract: Irradiation and fusion gene transfer (IFGT) is a technique that spans the gap between the limitations of molecular methods and somatic-cell genetics, allowing the separation of DNA fragments between 0.25 and 30 Mb in size. In conjunction with genetic linkage analysis and physical mapping techniques, IFGT provides a very useful addition to methods for cloning disease loci, and mapping chromosomes and entire genomes.
authors.affiliation: Department of Ophthalmology, University of Alberta, Edmonton, Canada.
authors.forename: M A
authors.initials: MA
authors.lastname: Walter
authors.forename: P N
authors.initials: PN
authors.lastname: Goodfellow
mesh_terms: D000818:Animals; D002459:Cell Fusion; D002460:Cell Line; D002874:Chromosome Mapping; D002875:Chromosomes / Q000235:genetics; D002877:Chromosomes, Human / Q000235:genetics* / Q000528:radiation effects; D005819:Genetic Markers; D006801:Humans; D006822:Hybrid Cells / Q000378:metabolism* / Q000528:radiation effects*; D051379:Mice; D011828:Radiation Chimera; D011995:Recombination, Genetic
chemical_list: D005819:Genetic Markers