Complex avoidance behaviour and its neurochemical regulation in the land snail Cepaea nemoralis.
1. In hot plate experiments, the pulmonate land snail Cepaea nemoralis displays a biphasic passive/active avoidance behaviour composed of retraction and subsequent searching mediated by antagonistic muscular systems. The switch, between the behaviours, is under neuronal control. 2. Leu- and met-enkephalin, as well as FMRFamide-antiserum, attenuated the retraction response and potentiated the searching behaviour. Opposite effects were achieved by injection of antisera to the enkephalins. 3. Both retraction and searching behaviours were potentiated by 5-HT. Methysergide antagonized the effects of the enkephalins on the searching behaviour. 4. We conclude that endogenous opioids act antagonistic to FMRFamide in the neuronally controlled switch between passive and active avoidance behaviour.
Dyakonova
V E
VE
Institute of Developmental Biology, Russian Academy of Sciences, Moscow.
Elofsson
R
R
Carlberg
M
M
Sakharov
D A
DA
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects / Q000502:physiology*; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology*; D004743:Enkephalin, Leucine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D004744:Enkephalin, Methionine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D019835:FMRFamide; D006358:Hot Temperature; D007447:Invertebrate Hormones / Q000037:antagonists & inhibitors / Q000276:immunology / Q000494:pharmacology; D008784:Methysergide / Q000494:pharmacology; D009479:Neuropeptides / Q000037:antagonists & inhibitors / Q000276:immunology / Q000494:pharmacology; D018377:Neurotransmitter Agents / Q000037:antagonists & inhibitors / Q000276:immunology / Q000494:pharmacology; D018847:Opioid Peptides / Q000037:antagonists & inhibitors / Q000494:pharmacology; D012701:Serotonin / Q000494:pharmacology; D012908:Snails / Q000502:physiology*
D007447:Invertebrate Hormones; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D018847:Opioid Peptides; D012701:Serotonin; D004744:Enkephalin, Methionine; D004743:Enkephalin, Leucine; D019835:FMRFamide; D008784:Methysergide