Role of heterotrimeric GTP binding proteins in vesicular protein transport: indications for both classical and alternative G protein cycles.
Heterotrimeric G proteins are involved in hormonal signal transduction across the plasma membrane. Recent evidence suggests that they have a role in vesicular protein transport as well. Biochemical probes that interfere with the classical G protein cycle have been applied to the field of intracellular membrane transport to study their mechanism of action. Evidence has been obtained that intracellular G proteins act both through classical and alternative G protein cycles.
Helms
J B
JB
Universität Heidelberg, Institut für Biochemie I, Germany.
D001692:Biological Transport; D002462:Cell Membrane / Q000378:metabolism*; D004705:Endocytosis / Q000502:physiology; D019204:GTP-Binding Proteins / Q000378:metabolism*; D006160:Guanosine Triphosphate / Q000378:metabolism*; D007425:Intracellular Membranes / Q000378:metabolism*; D008954:Models, Biological; D015388:Organelles / Q000378:metabolism; D011487:Protein Conformation; D011506:Proteins / Q000378:metabolism; D015398:Signal Transduction
D011506:Proteins; D006160:Guanosine Triphosphate; D019204:GTP-Binding Proteins