title: Giant congenital nevi. A clinical and histopathological study.
abstract: 17 cases of giant congenital nevi were reported. The lesions were located on the scalp, on the back and on the shoulders. The histopathological study revealed two cellular types of giant nevus; nevus cell type and neuroid type. Two types of neuroid structures were observed in neuroid type: Verocay bodies and pseudo-Meissnerian corpuscles. The congenital nature of a benign nevus includes the presence of nevus cells, single or in nests within the follicular epithelium, eccrine ducts or glands. Essentially, all giant nevi show conspicuous nevic cell permeation not only of the reticular dermis but typically also of the subcutis and even the fascia.
authors.affiliation: Department of Morphopathology, University of Medicine and Pharmacy, Jassy, Romania.
authors.forename: D
authors.initials: D
authors.lastname: Rădulescu
authors.forename: M
authors.initials: M
authors.lastname: Sârbu
mesh_terms: D000293:Adolescent; D000328:Adult; D002467:Cell Nucleus / Q000648:ultrastructure; D002648:Child; D003593:Cytoplasm / Q000648:ultrastructure; D006801:Humans; D008543:Melanins / Q000032:analysis; D008544:Melanocytes / Q000473:pathology; D008545:Melanoma; D009506:Nevus / Q000151:congenital* / Q000473:pathology*; D009508:Nevus, Pigmented / Q000473:pathology; D011230:Precancerous Conditions
chemical_list: D008543:Melanins