Ovarian teratomas in mice lacking the protooncogene c-mos.
Parthenogenesis has been suggested to be tightly coupled with development of ovarian teratomas. Indeed, ovarian tumors developed in c-mos-deficient female mice, which are characterized by the parthenogenetic activation of oocytes. The tumors appeared at a frequency of 30% between 4 and 8 months of age, and did not develop in younger or older mice. Most of the tumors were benign and consisted of multi-focal cysts most notably with mature ectodermal components, but also with mesodermal and endodermal components. One among 17 tumors observed consisted of extra-embryonic tissues alone, and two bore malignant components with metastasis to peritoneal organs. The results strongly suggest the involvement of c-mos mutations in human germ cell tumors.
Furuta
Y
Y
Department of Morphogenesis, Kumamoto University School of Medicine.
Shigetani
Y
Y
Takeda
N
N
Iwasaki
K
K
Ikawa
Y
Y
Aizawa
S
S
D000367:Age Factors; D000818:Animals; D005260:Female; D016258:Genes, mos; D006579:Heterozygote; D006720:Homozygote; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D010048:Ovarian Cysts / Q000235:genetics / Q000473:pathology; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D013724:Teratoma / Q000235:genetics* / Q000473:pathology