title: The treatment of chronic suppurative otitis media and otitis externa with 0.3 per cent ofloxacin otic solution: a clinico-microbiological study.
abstract: .3 per cent ofloxacin solution has been studied widely and has been proved to be safe in both animal and human studies. Ototoxicity and hair cell damage were not found in animal experiments. Ototopical treatment in both pediatric and adult patients was proved to be safe in previous studies. P. aeruginosa and S. aureus play the major role in both CSOM and OE, and most causative pathogens are susceptible to ofloxacin. This study showed that the use of 0.3 per cent ofloxacin otic solution was safe in both children and adults and yielded excellent clinical results.
authors.affiliation: Department of Otolaryngology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.
authors.forename: P
authors.initials: P
authors.lastname: Supiyaphun
authors.forename: K
authors.initials: K
authors.lastname: Tonsakulrungruang
authors.forename: L
authors.initials: L
authors.lastname: Chochaipanichnon
authors.forename: A
authors.initials: A
authors.lastname: Chongtateong
authors.forename: Y
authors.initials: Y
authors.lastname: Samart
mesh_terms: D000287:Administration, Topical; D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D002648:Child; D002908:Chronic Disease; D006801:Humans; D008826:Microbial Sensitivity Tests; D008875:Middle Aged; D015242:Ofloxacin / Q000008:administration & dosage / Q000627:therapeutic use*; D010032:Otitis Externa / Q000188:drug therapy* / Q000382:microbiology; D010035:Otitis Media, Suppurative / Q000188:drug therapy* / Q000382:microbiology
chemical_list: D000900:Anti-Bacterial Agents; D015242:Ofloxacin