title: Autologous glutaraldehyde-treated pericardial valved conduit: an experimental study.
abstract: Extracardiac conduits in the form of allografts and synthetic tubes containing heterograft valves have been used widely in the management of ventricular outflow abnormalities and for establishing ventriculoarterial continuity. These procedures are limited by long-term calcification as well as by formation of neointimal peel, necessitating reoperation. In an effort to continue the search for an alternative conduit, we designed and evaluated a valved sinus-bearing conduit fashioned out of autologous pericardium treated with glutaraldehyde. The construction of the conduit is described. The results of implantation of these conduits in 12 sheep showed no progression of gradients, fresh regurgitation, or evidence of wall or cusp calcification 9 months after implantation.
authors.affiliation: Department of Cardiovascular Diseases, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia.
authors.forename: M N
authors.initials: MN
authors.lastname: Kumar
authors.forename: G
authors.initials: G
authors.lastname: Prabakar
authors.forename: N
authors.initials: N
authors.lastname: Kumar
authors.forename: M
authors.initials: M
authors.lastname: Shahid
authors.forename: A E
authors.initials: AE
authors.lastname: Becker
authors.forename: C M
authors.initials: CM
authors.lastname: Duran
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D001807:Blood Vessel Prosthesis; D004452:Echocardiography; D005976:Glutaral; D006350:Heart Valve Prosthesis; D010496:Pericardium; D012756:Sheep; D014182:Transplantation, Autologous
chemical_list: D005976:Glutaral