Enhancement of interleukin-6 production by fibrinogen degradation product D in human peripheral monocytes and perfused murine liver.
The effect of fibrinogen degradation products D and E (FDP-D, FDP-E) on IL-6 production in perfused mouse livers and peripheral monocytes is studied. Similarly to bacterial endotoxin FDP-D is highly potent to augment the IL-6 production measured in perfused mouse livers, while FDP-E is not stimulatory. FDP-D but not FDP-E is able to stimulate the in vitro IL-6 production of human peripheral monocytes, as well. Plasmin alone is almost ineffective on IL-6 production both in perfused livers and monocytes. Our findings suggest a direct positive feedback circuit, among fibrinogen, FDP and IL-6.
Mandl
J
J
First Department of Biochemistry, Semmelweis University of Medicine, Budapest, Hungary.
Csala
M
M
Léránt
I
I
Bánhegyi
G
G
Biró
J
J
Machovich
R
R
Falus
A
A
D000328:Adult; D000818:Animals; D005338:Fibrin Fibrinogen Degradation Products / Q000502:physiology*; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis*; D008099:Liver / Q000378:metabolism*; D051379:Mice; D009000:Monocytes / Q000378:metabolism*; D015854:Up-Regulation / Q000276:immunology
D005338:Fibrin Fibrinogen Degradation Products; D015850:Interleukin-6