[The efficacy of an erythropoietin-calcitriol combination in patients with chronic kidney failure on programmed hemodialysis].
In 8 patients with chronic renal failure (CRF) on hemodialysis combined therapy (erythropoietin+calcitriol) effect was evaluated versus control group of 9 hemodialysis patients on erythropoietin monotherapy. In patients on the combined regimen the antianemic effect occurred sooner, this effect of calcitriol coming prior to correction of uremic defects in phosphoric-calcium metabolism. Calcitriol mechanisms of action in renal anemia and benefits of potential calcitriol+erythropoietin combination use in CRF patients suffering from uremic osteodystrophy, hypercatabolic conditions, uremic hypogonadism and infection complications are discussed.
Nikolaev
A Iu
AIu
Klepikov
P V
PV
Lashutin
S V
SV
Kukhtevich
A V
AV
D000328:Adult; D000740:Anemia / Q000209:etiology / Q000517:prevention & control; D002117:Calcitriol / Q000009:adverse effects / Q000627:therapeutic use*; D002118:Calcium / Q000097:blood; D003131:Combined Modality Therapy; D004341:Drug Evaluation; D004359:Drug Therapy, Combination; D004921:Erythropoietin / Q000009:adverse effects / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D007676:Kidney Failure, Chronic / Q000097:blood / Q000150:complications / Q000628:therapy*; D008297:Male; D008875:Middle Aged; D010758:Phosphorus / Q000097:blood; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D006435:Renal Dialysis
D011994:Recombinant Proteins; D004921:Erythropoietin; D010758:Phosphorus; D002117:Calcitriol; D002118:Calcium
Effektivnost' sochetaniia éritropoétin-kal'tsitriola u bol'nykh s khronicheskoĭ pochechnoĭ nedostatochnost'iu, nakhodiashchikhsia na programmnom gemodialize.