title: [Methotrexate treatment of amyloidosis secondary to rheumatoid arthritis].
abstract: Amyloidosis secondary to rheumatoid arthritis is a complication with a poor prognosis and as yet an undefined medical therapy. In the last decades the use of different cytostatics has been advocated to avoid renal function deterioration. The clinical characteristics and course in eight patients with amyloidosis secondary to rheumatoid arthritis are here reported after therapy with low dosage methotrexate. In twelve patients who followed a 12-month therapy a clinical improvement was observed, with a marked decrease in proteinuria; in one of them proteinuria disappeared. These results suggest that methotrexate at low doses might be an alternative in the early treatment of amyloidosis secondary to rheumatoid arthritis in patients with preserved renal function.
authors.affiliation: Servicio de Reumatología, Hospital Prínceps d'Espanya, Ciutat Sanitària, L'Hospitalet de Llobregat, Barcelona.
authors.forename: J
authors.initials: J
authors.lastname: Fiter
authors.forename: J M
authors.initials: JM
authors.lastname: Nolla
authors.forename: J
authors.initials: J
authors.lastname: Valverde
authors.forename: D
authors.initials: D
authors.lastname: Roig Escofet
mesh_terms: D000686:Amyloidosis / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D001172:Arthritis, Rheumatoid / Q000150:complications*; D005260:Female; D006801:Humans; D007674:Kidney Diseases / Q000175:diagnosis / Q000188:drug therapy* / Q000209:etiology; D007677:Kidney Function Tests; D008297:Male; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D008875:Middle Aged; D012189:Retrospective Studies; D013997:Time Factors
chemical_list: D008727:Methotrexate
vernacular_title: Tratamiento con metotrexato de la amiloidosis secundaria a la artritis reumatoide.