Crude extracts of hepatoprotective plants, Solanum nigrum and Cichorium intybus inhibit free radical-mediated DNA damage.
The presence of plant extracts of Solanum nigrum and Cichorium intybus in the reaction mixture containing calf thymus DNA and free radical generating system protect DNA against oxidative damage to its deoxyribose sugar moiety. The effect was dependent on the concentration of plant extracts. However, the effect of Cichorium intybus was much pronounced as compared to the effect of Solanum nigrum. These studies suggest that the observed hepatoprotective effect of these crude plant extracts may be due to their ability to suppress the oxidative degradation of DNA in the tissue debris.
Sultana
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Department of Medical Elementology and Toxicology, Jamia Hamdard (Hamdard University) Hamdard Nagar, New Delhi, India.
Perwaiz
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Iqbal
M
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Athar
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M
D000085:Acetates / Q000737:chemistry; D000818:Animals; D001554:Benzene / Q000737:chemistry; D002417:Cattle; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004249:DNA Damage / Q000187:drug effects*; D003855:Deoxyribose / Q000235:genetics / Q000378:metabolism; D000431:Ethanol / Q000737:chemistry; D005609:Free Radicals / Q000009:adverse effects; D008099:Liver / Q000187:drug effects*; D018384:Oxidative Stress / Q000187:drug effects; D010936:Plant Extracts / Q000494:pharmacology*; D013950:Thymus Gland / Q000187:drug effects / Q000378:metabolism
D000085:Acetates; D005609:Free Radicals; D010936:Plant Extracts; D000431:Ethanol; D003855:Deoxyribose; C007650:ethyl acetate; D004247:DNA; D001554:Benzene