[Effect of gonadotrophins, testosterone and growth hormone on spermatogenesis in two hypophysectomy patients].
Human chorionic gonadotrophin (hCG), human menopausal gonadotrophins (hMG) and somatotrope hormone (STH) were used for three months to induce spermatogenesis in a patient with azoospermia following hypophysectomy for Cushing's syndrome. Azoospermia reappeared when testosterone was substituted for hCG, despite continued treatment with FSH and STH. In a second patient who had undergone hypophysectomy for a craniopharyngioma presenting residual oligospermia, STH alone was uneffective in improving the sperm count. In both patients, the level of IGF-1 in seminal fluid was unchanged by STH despite increased serum IGF-1. The use of STH to induce spermatogenesis is discussed in light of its capacity to increase testosterone synthesis is response to hCG.
Martin-Du Pan
R C
RC
Clinique de Stérilité et d'Endocrinologie de la Reproduction, Hôpital Cantonal Universitaire de Genève, Suisse.
Aubert
M L
ML
Biondo
M
M
Campana
A
A
D000328:Adult; D006063:Chorionic Gonadotropin / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005640:Follicle Stimulating Hormone / Q000627:therapeutic use; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007016:Hypophysectomy / Q000009:adverse effects*; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D008297:Male; D008596:Menotropins / Q000627:therapeutic use*; D009845:Oligospermia / Q000188:drug therapy* / Q000209:etiology; D013091:Spermatogenesis / Q000187:drug effects; D013094:Spermatozoa / Q000737:chemistry; D013739:Testosterone / Q000627:therapeutic use*
D006063:Chorionic Gonadotropin; D013739:Testosterone; D008596:Menotropins; D007334:Insulin-Like Growth Factor I; D005640:Follicle Stimulating Hormone; D013006:Growth Hormone
Effet des gonadotrophines, de la testostérone et de l'hormone de croissance sur la spermatogenèse chez deux patients hypophysectomisés.