title: Increases and time-course variations in beta-hexosaminidase isoenzyme B and carbohydrate-deficient transferrin in serum from alcoholics are similar.
abstract: beta-Hexosaminidase B-isoforms (beta-hexosaminidase B, P, and intermediate forms; abbreviated herein as "Hex B") and serum carbohydrate-deficient transferrin (CDT) are two markers of alcohol abuse. In the present study, we have compared "Hex B" with CDT as markers of alcohol abuse in a group of alcoholics hospitalized for detoxification after a period of heavy alcohol abuse. We have also followed the disappearance rate of these two markers from circulation. "Hex B" was elevated in 38 of 42 patients hospitalized for detoxication, whereas CDT was elevated in 35 of 42 patients. A highly significant correlation was noted between "Hex B" and CDT in these patients (p = 0.52, p < 0.001). Neither "Hex B" nor CDT correlated with gamma-glutamyltransferase or AST. The disappearance rates from serum of "Hex B" and CDT were determined in 21 hospitalized patients followed for up to 15 days. "Hex B" and CDT showed similar time-course variation and half-lives, 6.5 +/- 3.7 (mean +/- SD) and 8.6 +/- 4.1 days, respectively. The possible reasons for a relation between these two markers are discussed, and it is concluded that more experience of both "Hex B" and CDT in unselected populations is needed to establish the diagnostic potential of these tests as markers of alcohol abuse.
authors.affiliation: Department of Clinical Chemistry, University Hospital, Lund, Sweden.
authors.forename: B
authors.initials: B
authors.lastname: Hultberg
authors.forename: A
authors.initials: A
authors.lastname: Isaksson
authors.forename: M
authors.initials: M
authors.lastname: Berglund
authors.forename: C
authors.initials: C
authors.lastname: Alling
mesh_terms: D000328:Adult; D000437:Alcoholism / Q000175:diagnosis / Q000201:enzymology* / Q000534:rehabilitation; D015415:Biomarkers / Q000097:blood; D005260:Female; D006207:Half-Life; D054819:Hexosaminidase B; D006801:Humans; D007527:Isoenzymes / Q000097:blood*; D008111:Liver Function Tests; D008297:Male; D008875:Middle Aged; D012016:Reference Values; D014168:Transferrin / Q000031:analogs & derivatives* / Q000378:metabolism; D001619:beta-N-Acetylhexosaminidases / Q000097:blood*
chemical_list: D015415:Biomarkers; D007527:Isoenzymes; D014168:Transferrin; C056759:carbohydrate-deficient transferrin; D054819:Hexosaminidase B; D001619:beta-N-Acetylhexosaminidases