Myocardial regeneration. Transplanting satellite cells into damaged myocardium.
Millions of Americans suffer from chronic heart failure. Despite treatments with heart transplantation, cardiomyoplasty, and artificial assist devices, an ideal therapy is yet to be found. Since 1988, we have studied the transplantation of myogenic stem cells from skeletal muscle into injured myocardium in the hope that these cells would multiply and differentiate, thereby improving the function of the failing heart. We have achieved 2 goals thus far: the 1st was improving the culture technique to obtain high yield and purity of the satellite cells; the 2nd was successfully implanting cultured satellite cells in dog hearts and later identifying them as new myocardium. We share our findings here to encourage more study in this promising area.
Yoon
P D
PD
Cardiothoracic Surgical Research, Allegheny-Singer Research Institute, Pittsburgh, Pennsylvania, USA.
Kao
R L
RL
Magovern
G J
GJ
D000818:Animals; D002454:Cell Differentiation / Q000502:physiology; D002470:Cell Survival / Q000502:physiology; D002478:Cells, Cultured; D004285:Dogs; D006333:Heart Failure / Q000473:pathology / Q000601:surgery; D016027:Heart Transplantation / Q000473:pathology*; D018482:Muscle, Skeletal / Q000473:pathology / Q000637:transplantation*; D009206:Myocardium / Q000473:pathology*; D012038:Regeneration / Q000502:physiology*; D033581:Stem Cell Transplantation; D013234:Stem Cells / Q000473:pathology