title: Dual receptor T-cells. Implications for alloreactivity and autoimmunity.
abstract: Using monoclonal antibodies to human V alpha, we have estimated that up to one-third of mature T-cells express two V alpha chains as part of two functional and independent T-cell receptors. Cells belonging to this dual TCR subset may be specific for a broader range of antigens than cells with a single receptor. We discuss the possibility that dual receptor T-cells may be involved in alloreactivity and autoimmunity.
authors.affiliation: Basel Institute for Immunology, Switzerland.
authors.forename: E
authors.initials: E
authors.lastname: Padovan
authors.forename: G
authors.initials: G
authors.lastname: Casorati
authors.forename: P
authors.initials: P
authors.lastname: Dellabona
authors.forename: C
authors.initials: C
authors.lastname: Giachino
authors.forename: A
authors.initials: A
authors.lastname: Lanzavecchia
mesh_terms: D000483:Alleles; D001324:Autoantigens / Q000276:immunology; D015551:Autoimmunity; D002454:Cell Differentiation; D006801:Humans; D016693:Receptors, Antigen, T-Cell, alpha-beta / Q000737:chemistry* / Q000235:genetics; D013601:T-Lymphocytes / Q000737:chemistry*; D013950:Thymus Gland / Q000166:cytology
chemical_list: D001324:Autoantigens; D016693:Receptors, Antigen, T-Cell, alpha-beta