title: Flare phenomenon in osteosarcoma after complete remission.
abstract: A patient undergoing cytostatic therapy for osteosarcoma of the right humerus had bone scans at 2-mo intervals. A skeletal focus of increased radiotracer accumulation occurred and subsequently was confirmed by CT and MRI. A necrotic metastasis was found during biopsy. There were no remaining viable tumor cells. This finding confirms the presence of the flare phenomenon in skeletal metastases in primary malignant bone tumors and that radionuclide imaging may fail to detect intramedullary foci of viable metastases in these tumors.
authors.affiliation: Department of Diagnostic Radiology, University Hospital, Lund, Sweden.
authors.forename: K
authors.initials: K
authors.lastname: Herrlin
authors.forename: H
authors.initials: H
authors.lastname: Willén
authors.forename: T
authors.initials: T
authors.lastname: Wiebe
mesh_terms: D000293:Adolescent; D000970:Antineoplastic Agents / Q000627:therapeutic use; D001859:Bone Neoplasms / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary*; D005266:Femoral Neoplasms / Q000000981:diagnostic imaging / Q000556:secondary*; D006801:Humans; D006811:Humerus; D008297:Male; D012516:Osteosarcoma / Q000000981:diagnostic imaging* / Q000188:drug therapy / Q000556:secondary*; D011630:Pubic Bone; D011877:Radionuclide Imaging
chemical_list: D000970:Antineoplastic Agents