Alterations of the post transplant blood lymphocyte phenotype subsets as a marker of rejection in renal allograft recipients.
The postoperative alterations of absolute levels of lymphocyte phenotype subsets in peripheral blood were studied in recipients of living donor renal allografts and in kidney donors. The results were expressed as per cent changes of the preoperative values. The lymphocyte subsets, CD3, CD4 and CD8 cells, decreased to approximately 50% following the surgical trauma, with rapid recovery to preoperative levels within 1 week in kidney donors and in recipients without rejection episodes. In contrast, the T-cell levels in recipients with rejection episodes remained low after 1 week, before clinical signs of rejection, and was predictive for the later occurrence of acute rejection episodes. The T-cell levels in the recipients with rejection episodes remained low during the first 6 weeks, maybe due to the rejection treatments given during this period. The B-lymphocytes were not affected in any of the recipient groups. The alterations observed were not explained by CMV infections, which occurred mainly after the observation period of 6 weeks. In conclusion, the operation per se induced alterations in circulating T-lymphocyte subsets and low T-cell levels after 1 week were predictive of rejection episodes.
Wramner
L
L
Department of Surgery, Sahlgrenska Hospital, University of Göteborg, Sweden.
Mjörnstedt
L
L
Blohmé
I
I
Tufveson
G
G
Söderström
T
T
Olausson
M
M
D000328:Adult; D000368:Aged; D015703:Antigens, CD / Q000276:immunology; D001402:B-Lymphocytes / Q000276:immunology; D015415:Biomarkers; D005260:Female; D006084:Graft Rejection / Q000276:immunology*; D006801:Humans; D016130:Immunophenotyping; D016030:Kidney Transplantation; D008297:Male; D008875:Middle Aged; D016176:T-Lymphocyte Subsets / Q000276:immunology*; D014184:Transplantation, Homologous
D015703:Antigens, CD; D015415:Biomarkers