title: Prognostic value of neural invasion in rectal carcinoma: a multivariate analysis on 339 patients with curative resection.
abstract: To determine whether neural invasion or other clinico-pathological factors are prognostic, we performed a retrospective study on 339 rectal carcinomas. The overall 5-year survival was 62%. In the multivariate analysis, age over 60 years, a distance from the anal verge of less than 6 cm, the number of positive lymph nodes, neural invasion and tumour penetration were found to be prognostic. A scoring system identified five prognostic groups of patients. Neural invasion is an independent prognostic factor in our scoring system and it is suggested that this parameter should be taken into consideration for postsurgical treatment.
authors.affiliation: Département d'Anatomopathologie, Institut Gustave Roussy, Villejuif, France.
authors.forename: C
authors.initials: C
authors.lastname: Bognel
authors.forename: C
authors.initials: C
authors.lastname: Rekacewicz
authors.forename: H
authors.initials: H
authors.lastname: Mankarios
authors.forename: J P
authors.initials: JP
authors.lastname: Pignon
authors.forename: D
authors.initials: D
authors.lastname: Elias
authors.forename: P
authors.initials: P
authors.lastname: Duvillard
authors.forename: M
authors.initials: M
authors.lastname: Prade
authors.forename: M
authors.initials: M
authors.lastname: Ducreux
authors.forename: J
authors.initials: J
authors.lastname: Kac
authors.forename: P
authors.initials: P
authors.lastname: Rougier
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D008207:Lymphatic Metastasis; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D009361:Neoplasm Invasiveness; D009423:Nervous System Neoplasms / Q000401:mortality / Q000473:pathology / Q000556:secondary*; D011379:Prognosis; D012004:Rectal Neoplasms / Q000401:mortality / Q000473:pathology* / Q000601:surgery; D012189:Retrospective Studies; D016019:Survival Analysis