title: High prevalence of thyroxine-binding globulin deficiency among Bedouin infants in southern Israel.
abstract: A high prevalence of thyroxine-binding globulin deficiency was found among Bedouin newborns in the Negev area (southern Israel) during a study lasting 2 years. This prevalence is significantly higher than those reported in other populations. Moreover, thyroxine-binding globulin deficiency was found to be more common than congenital hypothyroidism among the Bedouin. The results of thyroxine-binding globulin analysis in four patients may suggest the coexistence of at least two different mutations among the Bedouin population.
authors.affiliation: Pediatric Endocrine Unit, Soroka University Hospital, Beer Sheva, Israel.
authors.forename: E
authors.initials: E
authors.lastname: Hershkovitz
authors.forename: E
authors.initials: E
authors.lastname: Leiberman
authors.forename: S
authors.initials: S
authors.lastname: Refetoff
authors.forename: D
authors.initials: D
authors.lastname: Pilpell
authors.forename: M
authors.initials: M
authors.lastname: Phillip
mesh_terms: D005006:Ethnicity; D006801:Humans; D007231:Infant, Newborn; D007557:Israel / Q000453:epidemiology; D008297:Male; D008661:Metabolism, Inborn Errors / Q000097:blood / Q000175:diagnosis / Q000208:ethnology*; D015995:Prevalence; D013972:Thyrotropin / Q000097:blood; D013974:Thyroxine / Q000097:blood; D013975:Thyroxine-Binding Proteins / Q000172:deficiency*; D014284:Triiodothyronine / Q000097:blood
chemical_list: D013975:Thyroxine-Binding Proteins; D014284:Triiodothyronine; D013972:Thyrotropin; D013974:Thyroxine