Liver injuries induced by herbal medicine, syo-saiko-to (xiao-chai-hu-tang).
Four patients treated with the herbal medicine syo-saiko-to (xiao-chai-hu-tang) exhibited acute drug-induced liver injury. The latent period was one and a half to three months. All of the patients showed a rise in aminotransferases after readministration or challenge test. The liver histology revealed centrilobular confluent necrosis or spotty necrosis, microvesicular fatty change, acidophilic degeneration, and a granuloma. Cholestasis was seen in two patients. The results of the [13C]aminopyrine breath test, performed in one patient, were low before the challenge test and even lower after the challenge. These findings suggest that the herbal medicine syo-saiko-to may induce acute injury or the hepatocellular pattern with variable cholestasis.
Itoh
S
S
Department of Medicine 3, Saitama Medical School, Japan.
Marutani
K
K
Nishijima
T
T
Matsuo
S
S
Itabashi
M
M
D056486:Chemical and Drug Induced Liver Injury; D004365:Drugs, Chinese Herbal / Q000009:adverse effects*; D005260:Female; D006801:Humans; D008099:Liver / Q000473:pathology; D008107:Liver Diseases / Q000473:pathology; D008875:Middle Aged
D004365:Drugs, Chinese Herbal; C018142:saiko-keishi-to