The open infarct-related artery theory: a critical view.
Early reopening of the infarct-related artery salvages myocardium and, consequently, preserves left ventricular function, which results in an improved survival rate (the early open infarct-related artery theory). Nevertheless, late patency of the infarct-related artery is also important, because it prevents ventricular remodeling (the late-open infarct-related theory). A comprehensive view of the importance of both conditions is presented.
Geraci
E
E
Division of Cardiology, V. Cervello Hospital, Palermo, Italy.
Tognoni
G
G
D003331:Coronary Vessels; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000627:therapeutic use; D006801:Humans; D007558:Italy / Q000453:epidemiology; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality*; D015996:Survival Rate; D015912:Thrombolytic Therapy; D014654:Vascular Patency; D016277:Ventricular Function, Left
D005343:Fibrinolytic Agents