title: Myosin structure/function: a combined mutagenesis-crystallography approach.
abstract: In the past year, the structure of the regulatory domain of scallop myosin has joined that of the chicken skeletal muscle myosin subfragment 1 and provided insights into the regulation of myosin function. Mutagenesis studies in a variety of systems have used the information provided by these structures to create mutant myosins to test models of chemomechanical transduction and its regulation.
authors.affiliation: Department of Biochemistry and Developmental Biology, Stanford University School of Medicine, CA 94305, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Ruppel
authors.forename: M
authors.initials: M
authors.lastname: Lorenz
authors.forename: J A
authors.initials: JA
authors.lastname: Spudich
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D000818:Animals; D001665:Binding Sites; D002118:Calcium / Q000378:metabolism; D018360:Crystallography, X-Ray; D008958:Models, Molecular; D016296:Mutagenesis; D009218:Myosins / Q000737:chemistry* / Q000502:physiology*; D017433:Protein Structure, Secondary; D017434:Protein Structure, Tertiary
chemical_list: D000255:Adenosine Triphosphate; D009218:Myosins; D002118:Calcium