title: The novel desmethyldestruxin B2, from Metarhizium anisopliae, that suppresses hepatitis B virus surface antigen production in human hepatoma cells.
abstract: We have examined the antiviral activity of a crude extract prepared from the culture medium of the fungus Metarhizium anisopliae. Eight active destruxins were identified which showed strong suppressive effect on the production of the hepatitis B surface antigen (HBsAg) in human hepatoma Hep3B cells. One new compound, desmethyldestruxin B2 [1], was isolated from M. anisopliae. This structure was determined based on its nmr and mass spectral data.
authors.affiliation: Institute of Biochemistry, National Yang-Ming University, Taipei, Taiwan.
authors.forename: H
authors.initials: H
authors.lastname: Chen
authors.forename: S F
authors.initials: SF
authors.lastname: Yeh
authors.forename: G T
authors.initials: GT
authors.lastname: Ong
authors.forename: S H
authors.initials: SH
authors.lastname: Wu
authors.forename: C M
authors.initials: CM
authors.lastname: Sun
authors.forename: C K
authors.initials: CK
authors.lastname: Chou
mesh_terms: D000818:Animals; D003470:Culture Media; D006514:Hepatitis B Surface Antigens / Q000096:biosynthesis*; D006801:Humans; D008114:Liver Neoplasms, Experimental / Q000378:metabolism*; D009682:Magnetic Resonance Spectroscopy; D013058:Mass Spectrometry; D003904:Mitosporic Fungi / Q000737:chemistry*; D010456:Peptides, Cyclic / Q000737:chemistry / Q000302:isolation & purification / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
chemical_list: D003470:Culture Media; D006514:Hepatitis B Surface Antigens; D010456:Peptides, Cyclic; C094783:desmethyldestruxin B2