title: Perineural infiltration by cutaneous squamous cell carcinomas of the head and neck.
abstract: In this paper six cases of cutaneous squamous cell carcinoma of the head and neck region with histologically-documented perineural tumoral infiltration are presented. Most patients showed recurrent disease during follow-up and have been treated with surgery and radiotherapy with or without systemic chemotherapy. The prognostic implications of perineural neoplastic infiltration as well as of therapeutic options are discussed.
authors.affiliation: Chair of Plastic Surgery, University of Palermo, Italy.
authors.forename: C
authors.initials: C
authors.lastname: Di Gregorio
authors.forename: V
authors.initials: V
authors.lastname: Gebbia
authors.forename: A M
authors.initials: AM
authors.lastname: Florena
authors.forename: V
authors.initials: V
authors.lastname: Franco
authors.forename: F
authors.initials: F
authors.lastname: Moschella
mesh_terms: D000368:Aged; D002294:Carcinoma, Squamous Cell / Q000473:pathology* / Q000556:secondary* / Q000601:surgery / Q000628:therapy; D005260:Female; D005500:Follow-Up Studies; D006258:Head and Neck Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D006801:Humans; D008297:Male; D008875:Middle Aged; D009380:Neoplasms, Nerve Tissue / Q000473:pathology / Q000556:secondary* / Q000601:surgery; D011379:Prognosis; D012008:Recurrence; D012878:Skin Neoplasms / Q000473:pathology* / Q000601:surgery / Q000628:therapy; D013524:Surgical Flaps