Cytologic screening after hysterectomy for benign disease.
OBJECTIVE
Our purpose was to determine the effectiveness of vaginal cytology tests after hysterectomy for benign disease.


METHODS
We studied a 10-year retrospective cohort of patients after hysterectomy (n = 697 women, 9074 woman years). Patients were excluded if they had any type of invasive gynecologic malignancy. The main outcome variable was development of a vaginal cytologic abnormality, evaluated with Kaplan-Meier estimates and proportional hazards regression.


RESULTS
We found 33 abnormal cytology results; most were of little clinical significance except for two biopsy-proven dysplasia cases. When we controlled for age, the risk was 4.67 for patients with a history of a cervical cytologic abnormality (95% confidence interval 2.1 to 10.6). We needed 633 tests to detect one true positive case of vaginal dysplasia.


CONCLUSIONS
The low incidence of vaginal dysplasia and carcinoma, combined with the high false-positive rate, supports decreasing the number of screening tests performed for these low-risk patients.
Piscitelli
J T
JT
Division of General Obstetrics-Gynecology, Duke University, Durham, NC, USA.
Bastian
L A
LA
Wilkes
A
A
Simel
D L
DL
D000328:Adult; D001706:Biopsy; D002584:Cervix Uteri / Q000473:pathology; D003581:Cytodiagnosis / Q000191:economics; D005189:False Positive Reactions; D005260:Female; D005831:Genital Diseases, Female / Q000601:surgery; D006801:Humans; D007044:Hysterectomy; D015993:Life Tables; D008875:Middle Aged; D016016:Proportional Hazards Models; D012189:Retrospective Studies; D012307:Risk Factors; D014621:Vagina / Q000473:pathology*; D014625:Vaginal Neoplasms / Q000175:diagnosis* / Q000191:economics; D014626:Vaginal Smears