Head and neck carcinoma in Fanconi's anaemia--report of a case and review of the literature.
Fanconi's anaemia (FA) is a rare autosomal recessive syndrome characterised by progressive lethal pancytopenia, skeletal abnormalities, hyperpigmentation and increased chromosomal aberrations. A high incidence of leukaemia and hepatocellular and squamous cell carcinomas (SCC) have been reported in FA patients. A rare case of SCC of the dorsum of the tongue in a FA patient is presented. A review of the reported cases of head and neck carcinoma in FA patients shows a different male:female ratio than previously reported, and a high incidence of carcinoma of the tongue.
Lustig
J P
JP
Department of Oral and Maxillofacial Surgery, Barzilai Medical Center, Ashkelon, Israel.
Lugassy
G
G
Neder
A
A
Sigler
E
E
D000328:Adult; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D005199:Fanconi Anemia / Q000150:complications*; D005260:Female; D006258:Head and Neck Neoplasms / Q000150:complications*; D006801:Humans; D015994:Incidence; D008297:Male; D017678:Sex Distribution; D014062:Tongue Neoplasms / Q000150:complications