In vivo metabolism of aminopyrine by the larvae of the helminth Heligmosomoides polygyrus.
The in vivo N-dealkylation of [13C-2]-labeled aminopyrine by the L1-L2 larvae of Heligmosomoides polygyrus was demonstrated by the use of a sensitive gas chromatography-mass spectrometry method. This is the first evidence for the possible existence of a cytochrome P-450-dependent activity in helminths.
Kerboeuf
D
D
Institut National de la Recherche Agronomique, Unité d'Helminthologie, Centre de Recherches de Tours, Nouzilly, France.
Soubieux
D
D
Guilluy
R
R
Brazier
J L
JL
Rivière
J L
JL
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000632:Aminopyrine / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D002849:Chromatography, Gas; D003640:Dealkylation / Q000187:drug effects; D004121:Dimethyl Sulfoxide / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology; D007814:Larva / Q000378:metabolism; D013058:Mass Spectrometry; D051379:Mice; D009351:Nematospiroides dubius / Q000187:drug effects / Q000378:metabolism*
D000317:Adrenergic alpha-Antagonists; D007093:Imidazoles; D000632:Aminopyrine; C017062:1-benzylimidazole; D004121:Dimethyl Sulfoxide