[The role of sympathetic mechanism in the effect of electroacupuncture on immunoregulation].
1. In normal control mice (only injected SRBC) after EA the lymphocyte transformation test (LTT, P < 0.05) and interlukin-2 (IL-2) activity (P < 0.05) were significantly increased, but the serum lysozyme (IZM, P < 0.01) was apparantly decreased. 2. After injection of 6-OHDA in mice, the spleen weight, spleen index, thymus weight, thymusindex, spleen lymphocyte population and serum IZM, igG contents were markedly decreased, whereas LTT, IL-2 and plaque forming cell (PFC) were umchanged, In contrast, the thymus lymphocyte population was markedly increased. 3. After EA of mice axotomized sympathetic nerve with 6-OHDA the above mentioned immune parameters deceased by 6-OHDA could be returned to normal or nearing normal levels. However, the unchanged LTT, IL-2 and the increased thymus lymphocyte population could be enhanced further, especially IL-2. These results suggest that peripheral sympathetic nerve may be participation in the EA-mediating immunological responses.
Zhao
J
J
Shaanxi Academy of Tradetional Chinese Medicine XI' An.
Zhao
X
X
Liu
W
W
Duan
X
X
Zhao
A
A
Zhao
G
G
Xue
F
F
Zhang
X
X
D000818:Animals; D015671:Electroacupuncture; D005260:Female; D007376:Interleukin-2 / Q000097:blood*; D008213:Lymphocyte Activation; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009113:Muramidase / Q000097:blood; D016627:Oxidopamine / Q000494:pharmacology; D013564:Sympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D013950:Thymus Gland / Q000166:cytology
D007376:Interleukin-2; D016627:Oxidopamine; D009113:Muramidase