title: A rapid test for measuring the infectivity of Yellow Fever vaccine.
abstract: An in-house reference preparation of 17D-204 Yellow Fever vaccine was tested 60 times using LD50 mouse assay and CCID50 method. The mean virus titre, standard deviation and coefficient of variation obtained were comparable. Student's t-test indicated that there was a statistically insignificant difference between the two methods (p > 0.05) used for potency test with a correlation coefficient of 0.666 (p < 0.05). CCID50 assay for measuring the infectivity of Yellow Fever vaccine is rapid, sensitive and reproducible.
authors.affiliation: Central Drugs Laboratory, Central Research Institute, Kasauli- India.
authors.forename: D K
authors.initials: DK
authors.lastname: Sood
authors.forename: R K
authors.initials: RK
authors.lastname: Aggarwal
authors.forename: S
authors.initials: S
authors.lastname: Kumar
authors.forename: J
authors.initials: J
authors.lastname: Sokhey
mesh_terms: D000818:Animals; D002522:Chlorocebus aethiops; D005069:Evaluation Studies as Topic; D005260:Female; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D011786:Quality Control; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014709:Vero Cells; D010948:Viral Plaque Assay; D014765:Viral Vaccines / Q000494:pharmacology* / Q000633:toxicity; D015005:Yellow fever virus / Q000276:immunology*
chemical_list: D014765:Viral Vaccines