title: Detection of Alzheimer disease in individuals with Down syndrome.
abstract: A comprehensive baseline of emotional functioning was established for adults with Down syndrome. Five emotional factors were studied using groups of (a) adults with Down syndrome (n = 30), (b) clinical control subjects with dementia of the Alzheimer type (n = 18), and (c) elderly control subjects without mental retardation (n = 25). Results of planned statistical comparisons showed indifference, pragnosia, and inappropriateness as primary emotional factors separating Down syndrome and Alzheimer disease groups from elderly control subjects without mental retardation. Indifference was also shown to covary with cognitive mental state, whereby increased levels of indifference were associated with decreased levels of cognitive functioning. The possibility of noncognitive variables signalling dementia of the Alzheimer type in individuals with Down syndrome was discussed.
authors.affiliation: University of California, Irvine, Department of Psychiatry, Orange 92668, USA.
authors.forename: L
authors.initials: L
authors.lastname: Nelson
authors.forename: I
authors.initials: I
authors.lastname: Lott
authors.forename: P
authors.initials: P
authors.lastname: Touchette
authors.forename: P
authors.initials: P
authors.lastname: Satz
authors.forename: L
authors.initials: L
authors.lastname: D'Elia
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000150:complications* / Q000175:diagnosis*; D004314:Down Syndrome / Q000150:complications*; D004644:Emotions; D005260:Female; D006801:Humans; D008297:Male; D009483:Neuropsychological Tests