title: A bolus for the administration to cattle of metacercariae of the liver fluke Fasciola hepatica.
abstract: A gelatin-agar bolus, designed and developed for the administration of metacercariae of the liver fluke Fasciola hepatica, was evaluated in adult Holstein Friesian cattle. The metacercariae, enclosed within a gelatin capsule, were placed inside the bolus and delivered to each animal using an oesophageal balling gun. At slaughter, 13 weeks after challenge, an average of 25% of the challenge dose was recovered from each liver. This percentage recovery is similar to that obtained with other known methods. The new bolus, however, offers improved handling qualities. In addition, the bolus also has potential for improving a number of other techniques including those for the administration of other parasites, compounds or chemotherapeutic agents.
authors.affiliation: Mallinckrodt Veterinary Ltd, Harefield, Uxbridge, Middlesex, UK.
authors.forename: S J
authors.initials: SJ
authors.lastname: Andrews
authors.forename: S
authors.initials: S
authors.lastname: McGonigle
authors.forename: A M
authors.initials: AM
authors.lastname: Smith
authors.forename: J P
authors.initials: JP
authors.lastname: Dalton
authors.forename: D
authors.initials: D
authors.lastname: Clery
authors.forename: G
authors.initials: G
authors.lastname: Mulcahy
mesh_terms: D000362:Agar; D000818:Animals; D002214:Capsules; D002417:Cattle; D005210:Fasciola hepatica; D005211:Fascioliasis / Q000469:parasitology*; D005780:Gelatin; D010274:Parasitology / Q000379:methods*
chemical_list: D002214:Capsules; D005780:Gelatin; D000362:Agar