An avian model for the reversal of 6-hydroxydopamine induced rotating behaviour by neural grafting.
A new animal model of parkinsonism was established in 'Black Silkie' chickens by means of unilateral injections of 6-hydroxy-dopamine into the substantia nigra. Apomorphine produced a strong contralateral turning pattern in the lesioned chickens, amphetamine had no effect. 6-OHDA treated animals received embryonic transplants of substantia nigra cell suspensions which caused them to cease rotating (P < 0.01). This finding allows us to add an avian model, which offers unique methodological advantages, for reversal of 6-OHDA-induced rotating behavior by transplantation.
Yanai
J
J
Melvin A. and Eleanor Ross Laboratory for Studies in Neural Birth Defects, Department of Anatomy and Embryology, Hebrew University-Hadassah Medical School, Jerusalem, Israel.
Silverman
W F
WF
Shamir
D
D
D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D016380:Brain Tissue Transplantation; D017690:Cell Transplantation; D002645:Chickens; D004195:Disease Models, Animal; D007150:Immunohistochemistry; D008297:Male; D009474:Neurons / Q000637:transplantation*; D016627:Oxidopamine / Q000494:pharmacology*; D010300:Parkinson Disease / Q000601:surgery; D013997:Time Factors
D016627:Oxidopamine