title: Clinical application of 18F-FUdR in glioma patients--PET study of nucleic acid metabolism.
abstract: Positron emission tomography was used to investigate the metabolism of nucleic acids by 18F-fluoro-2'-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 +/- 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 +/- 0.042 (p < 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.
authors.affiliation: Department of Neurosurgery, Tohoku University School of Medicine, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kameyama
authors.forename: K
authors.initials: K
authors.lastname: Ishiwata
authors.forename: Y
authors.initials: Y
authors.lastname: Tsurumi
authors.forename: J
authors.initials: J
authors.lastname: Itoh
authors.forename: K
authors.initials: K
authors.lastname: Sato
authors.forename: R
authors.initials: R
authors.lastname: Katakura
authors.forename: T
authors.initials: T
authors.lastname: Yoshimoto
authors.forename: J
authors.initials: J
authors.lastname: Hatazawa
authors.forename: M
authors.initials: M
authors.lastname: Ito
authors.forename: T
authors.initials: T
authors.lastname: Ido
mesh_terms: D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D005467:Floxuridine; D005462:Fluorine Radioisotopes; D005910:Glioma / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012334:RNA, Neoplasm / Q000378:metabolism*; D014055:Tomography, Emission-Computed
chemical_list: D004273:DNA, Neoplasm; D005462:Fluorine Radioisotopes; D012334:RNA, Neoplasm; D005467:Floxuridine