Cerebral metabolic change in patients with AIDS: report of a six-month follow-up using positron-emission tomography.
The authors examined change in cerebral metabolic function over time by using PET in HIV-infected individuals diagnosed with AIDS. Ten subjects with AIDS received [18F]2-fluoro-2-deoxy-D-glucose PET scans and completed a comprehensive neuropsychological battery. The scan and test battery were repeated after 6 months. Over time, the subjects showed increased relative basal ganglia metabolism as well as increased parietal lobe metabolism. There were no statistically significant changes in neuropsychological performance. These results suggest that PET may be more sensitive than traditional neuropsychological evaluation to subtle central nervous system changes in AIDS.
Hinkin
C H
CH
UCLA School of Medicine 90024-1759, USA.
van Gorp
W G
WG
Mandelkern
M A
MA
Gee
M
M
Satz
P
P
Holston
S
S
Marcotte
T D
TD
Evans
G
G
Paz
D H
DH
Ropchan
J R
JR
D015526:AIDS Dementia Complex / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000503:physiopathology; D000328:Adult; D001479:Basal Ganglia / Q000000981:diagnostic imaging / Q000503:physiopathology; D001727:Bisexuality; D001786:Blood Glucose / Q000378:metabolism*; D001921:Brain / Q000000981:diagnostic imaging* / Q000503:physiopathology; D001931:Brain Mapping; D003847:Deoxyglucose / Q000031:analogs & derivatives; D004734:Energy Metabolism / Q000502:physiology*; D019788:Fluorodeoxyglucose F18; D005500:Follow-Up Studies; D018451:Homosexuality, Male; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010296:Parietal Lobe / Q000000981:diagnostic imaging / Q000503:physiopathology; D014055:Tomography, Emission-Computed
D001786:Blood Glucose; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose