Gualamycin, a novel acaricide produced by Streptomyces sp. NK11687. II. Structural elucidation.
A novel acaricide, gualamycin was isolated from the culture broth of Streptomyces sp. NK11687. The structure of gualamycin was determined to be (2R,3S,4S)-2-O-[4-O-(2-amino-2-deoxy-beta-D-gulopyranosyl)-alpha-D - galactopyranosyl]-2,3,4-trihydroxy-4-[(2S,3S,4S,5S)-3,4-dihydroxy-5-hydr oxy - methylpyrrolidin-2-yl] butanoic acid by FAB-MS, 1H and 13C NMR, COSY, HMQC, HMBC, IR, X-ray crystallographic analyses and synthetic studies.
Tsuchiya
K
K
Applied Microbiology Research Center, Nippon Kayaku Co. Ltd., Saitama, Japan.
Kobayashi
S
S
Kurokawa
T
T
Nakagawa
T
T
Shimada
N
N
Nakamura
H
H
Iitaka
Y
Y
Kitagawa
M
M
Tatsuta
K
K
D004187:Disaccharides / Q000737:chemistry* / Q000302:isolation & purification; D007306:Insecticides / Q000737:chemistry* / Q000302:isolation & purification; D009682:Magnetic Resonance Spectroscopy; D015394:Molecular Structure; D011759:Pyrrolidines / Q000737:chemistry* / Q000302:isolation & purification; D013302:Streptomyces
D004187:Disaccharides; D007306:Insecticides; D011759:Pyrrolidines; C095342:gualamycin