Comparison of the efficacy of Brucella suis strain 2 and Brucella melitensis Rev. 1 live vaccines against a Brucella melitensis experimental infection in pregnant ewes.
The comparative efficacy of Brucella suis strain 2 (S2) and Brucella melitensis strain Rev. 1 (Rev. 1) live vaccines in protecting sheep against B. melitensis infection was evaluated by clinical and bacteriological examination of ewes vaccinated conjunctivally with a dose of 1 x 10(9) c.f.u. when 4 months old and then challenged with 5 x 10(7) c.f.u. of the B. melitensis virulent strain 53H38 (H38) at the middle of the first or second pregnancy following vaccination. Animals were considered to be protected when no abortion, no excretion of the challenge strain and no infection at slaughter occurred. The percentages of protection in Rev. 1-vaccinated groups challenged during either first (80%) or second (62%) pregnancy were significantly different (p < 0.001 and p < 0.05, respectively) compared with those of the relevant unvaccinated control groups. In contrast no significant difference in protection was found between the S2-vaccinated and control groups.
Verger
J M
JM
Laboratoire de Pathologie Infectieuse et d'Immunologie, INRA, Nouzilly, France.
Grayon
M
M
Zundel
E
E
Lechopier
P
P
Olivier-Bernardin
V
V
D000818:Animals; D002002:Brucella / Q000276:immunology*; D002004:Brucella Vaccine / Q000627:therapeutic use*; D017347:Brucella melitensis / Q000276:immunology*; D002006:Brucellosis / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D003228:Conjunctiva; D004305:Dose-Response Relationship, Drug; D004333:Drug Administration Routes; D005260:Female; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology / Q000517:prevention & control / Q000662:veterinary*; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology / Q000517:prevention & control*
D002004:Brucella Vaccine