Modulation of behavior by biogenic amines and peptides in the blue crab, Callinectes sapidus.
Using the blue crab Callinectes sapidus as a model system, we have investigated the effects of potential neuromodulators on freely behaving animals. Of interest is the modulatory effect of a number of drugs on three rhythmic behaviors of the blue crab: courtship display (CD) of the male crab, sideways swimming and backward swimming. The drugs tested were proctolin, dopamine, octopamine, serotonin, and norepinephrine. Injection of each drug elicited a unique posture or combination of limb movements. These experiments showed two results pertinent to CD behavior: A posture identical to the CD posture was displayed after dopamine injection; and rhythmic leg waving similar to CD was evoked by proctolin. An unusual combination of flexion and extension of all limbs and movements of some limbs occurred after serotonin injection. Injection of octopamine led to a posture antagonistic to CD posture. The effects of these drugs were concentration- and time-dependent. Injection of dopamine, octopamine, or serotonin produced effects that were seasonally-dependent, and the influence of proctolin proved to be dependent on developmental stage. Quantitative analysis of leg waving movements after proctolin injection allowed for comparison of these movements to naturally-occurring behavior.
Wood
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Georgia State University, Department of Biology, Atlanta 30302-4010, USA.
Gleeson
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Derby
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CD
D000375:Aging / Q000502:physiology; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects / Q000502:physiology*; D001679:Biogenic Amines / Q000502:physiology*; D003386:Brachyura / Q000235:genetics / Q000502:physiology*; D004298:Dopamine / Q000494:pharmacology; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D009479:Neuropeptides; D018377:Neurotransmitter Agents / Q000494:pharmacology / Q000502:physiology*; D009842:Oligopeptides / Q000494:pharmacology; D009994:Osmolar Concentration; D012621:Seasons; D012727:Sex Characteristics; D012726:Sexual Behavior, Animal / Q000187:drug effects; D013550:Swimming; D013997:Time Factors
D001679:Biogenic Amines; D009479:Neuropeptides; D018377:Neurotransmitter Agents; D009842:Oligopeptides; C011536:proctolin; D004298:Dopamine