Sequences of the cDNAs encoding canine parathyroid hormone-related protein and parathyroid hormone.
The cDNA clones encoding canine parathyroid-hormone-related protein (cPTHrP) and parathyroid hormone (cPTH) have been isolated and sequenced. The predicted amino-acid sequences of the mature canine homologs have a high degree of homology to human PTHrP (hPTHrP) and PTH (hPTH), especially in the biologically active regions. The cPTHrP cDNA is unique, since it has homology to exon 1A of hPTHrP which suggests that dogs utilize a promoter similar to P1 of hPTHrP which has not been demonstrated in other species.
Rosol
T J
TJ
Department of Veterinary Biosciences, Ohio State University, Columbus 43210, USA.
Steinmeyer
C L
CL
McCauley
L K
LK
Gröne
A
A
DeWille
J W
JW
Capen
C C
CC
D000230:Adenocarcinoma / Q000235:genetics; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D002417:Cattle; D018076:DNA, Complementary / Q000235:genetics; D004285:Dogs / Q000235:genetics*; D015723:Gene Library; D005796:Genes; D006801:Humans; D008969:Molecular Sequence Data; D009363:Neoplasm Proteins / Q000235:genetics; D010280:Parathyroid Glands / Q000378:metabolism; D010281:Parathyroid Hormone / Q000235:genetics*; D044162:Parathyroid Hormone-Related Protein; D010282:Parathyroid Neoplasms / Q000235:genetics; D011401:Promoter Regions, Genetic; D011506:Proteins / Q000235:genetics*; D017385:Sequence Homology; D013045:Species Specificity
D018076:DNA, Complementary; D009363:Neoplasm Proteins; C470121:PTHLH protein, human; D010281:Parathyroid Hormone; D044162:Parathyroid Hormone-Related Protein; D011506:Proteins