Immunohistochemical study of c-erb B-2 protein expression in endometriosis.
Using immunohistochemical techniques, we studied the expression of c-erb B-2 in normal human endometrial tissue (n = 8), endometriosis interna (adenomyosis) (n = 8) and endometriosis externa (endometriotic cyst of the ovary) (n = 6). The glandular epithelium of normal endometrial tissue specimens in the proliferative phase stained positively. Most of the cases of endometriosis studied showed no expression of c-erb B-2 in glandular epithelium. No expression was detected in either the normal or endometriotic stromal cells. Results suggest that c-erb B-2 is not significantly involved in the pathogenesis of endometriosis.
Nasu
K
K
Department of Obstetrics and Gynecology, Oita Medical University, Japan.
Hayata
T
T
Takai
N
N
Kawano
Y
Y
Sugano
T
T
Matsui
N
N
Miyakawa
I
I
D000328:Adult; D004715:Endometriosis / Q000378:metabolism*; D004717:Endometrium / Q000378:metabolism* / Q000473:pathology; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008565:Membrane Proteins / Q000032:analysis; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*
D008565:Membrane Proteins; D018719:Erb-b2 Receptor Tyrosine Kinases