Macquarimicins, microbial metabolites from Micromonospora. II. Isolation and structural elucidation.
A novel series of carbocyclic compounds has been isolated from two related Micromonospora cultures. The C-19 and C-22 macquarimicins represent different end products on a similar biosynthetic scheme. 1-D and 2-D homonuclear and heteronuclear NMR experiments allowed assignment of the basic structures of the macquarimicins. An X-ray structure of macquarimicin B suggested the stereochemistry for the series which was not discernible from spectroscopic data alone.
Hochlowski
J E
JE
Abbott Laboratories, Abbott Park, Illinois 60064, USA.
Mullally
M M
MM
Henry
R
R
Whittern
D M
DM
McAlpine
J B
JB
D000900:Anti-Bacterial Agents / Q000737:chemistry* / Q000302:isolation & purification*; D018942:Macrolides; D009682:Magnetic Resonance Spectroscopy; D008847:Micromonospora / Q000378:metabolism; D015394:Molecular Structure; D013237:Stereoisomerism
D000900:Anti-Bacterial Agents; D018942:Macrolides; C094822:macquarimicin A; C094823:macquarimicin B; C094824:macquarimicin C