[Experimental model of pulmonary bipartition with bilateral lobe transplantation in dogs and application to clinical medicine].
The crucial need for donors of paediatric or small sized organs has been a great obstacle to overcome in organ transplantation in children or small adults. Some progress in adapting size of the donor organs has been achieved with surgical procedures for reducing the size of donor organs, partial transplantation (single lobe of the liver or the lung) and liver partition, offering a partial solution to the insufficient supply of paediatric organs. We propose an experimental model in the dog of lung partition associated with monolateral (series I) or bilateral (series II) lobe transplantation. The results have been encouraging both in terms of quality of healing and in morphological and functional adaptation of the transplanted lobes, allowing us to apply this technique of lung partition and bilateral lobe transplantation in human patients. The outcome has been excellent in the first case after 18 months follow-up.
Couetil
J P
JP
Service de Chirurgie thoracique et cardiovasculaire, Hôpital Broussais, Paris.
Grousset
A
A
Benaim
D
D
Sapoval
M
M
Hernigou
A
A
Coppens
P
P
Fayolle
P
P
Carpentier
A
A
D000818:Animals; D001824:Body Constitution; D002648:Child; D004285:Dogs; D005240:Feasibility Studies; D006801:Humans; D008168:Lung / Q000033:anatomy & histology / Q000601:surgery*; D016040:Lung Transplantation
Mise au point expérimentale de la bipartition pulmonaire avec transplantation lobaire bilatérale chez le chien et application en clinique humaine.