Clinical application of 18F-FUdR in glioma patients--PET study of nucleic acid metabolism.
Positron emission tomography was used to investigate the metabolism of nucleic acids by 18F-fluoro-2'-deoxyuridine (18F-FUdR) in 22 patients with gliomas. Sixteen cases of high grade glioma clearly demonstrated a region of high activity with a differential absorption rate (DAR) of 0.64 +/- 0.34. Six cases of low grade glioma failed to reveal a positive image of the tumor and the DAR in tumor was 0.21 +/- 0.042 (p < 0.01). This PET-18F-FUdR study succeeded in differentiating high and low grade gliomas from the view point of nucleic acid metabolism.
Kameyama
M
M
Department of Neurosurgery, Tohoku University School of Medicine, Japan.
Ishiwata
K
K
Tsurumi
Y
Y
Itoh
J
J
Sato
K
K
Katakura
R
R
Yoshimoto
T
T
Hatazawa
J
J
Ito
M
M
Ido
T
T
D000328:Adult; D000368:Aged; D001932:Brain Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism*; D004273:DNA, Neoplasm / Q000378:metabolism*; D005260:Female; D005467:Floxuridine; D005462:Fluorine Radioisotopes; D005910:Glioma / Q000000981:diagnostic imaging* / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D012334:RNA, Neoplasm / Q000378:metabolism*; D014055:Tomography, Emission-Computed
D004273:DNA, Neoplasm; D005462:Fluorine Radioisotopes; D012334:RNA, Neoplasm; D005467:Floxuridine