Corticosterone regulates behavioral effects of lipopolysaccharide and interleukin-1 beta in mice.
The modulatory role of endogenous corticoids in the behavioral effects of lipopolysaccharide (LPS) and recombinant human interleukin-1 beta (IL-1 beta) was studied in mice. Adrenalectomy enhanced the depression of social exploration induced by subcutaneous injection of 200 ng of IL-1 beta or 2 micrograms of LPS. This effect was mimicked by an acute injection of the progesterone antagonist RU-38486 (0.25-1 mg). Chronic replacement with a 15-mg corticosterone pellet abrogated the enhanced susceptibility of adrenalectomized animals to 200 ng of IL-1 beta but had only partial protective effects on their response to 400 ng of IL-1 beta and LPS. These results suggest that the pituitary-adrenal response to cytokines exerts an inhibitory feedback on the cell targets that mediate the behavioral effects of LPS and IL-1 beta.
Goujon
E
E
Institut National de la Recherche Agronomique-Institut National de la Santé et de la Recherche Médicale Unité 394, Bordeaux, France.
Parnet
P
P
Aubert
A
A
Goodall
G
G
Dantzer
R
R
D000315:Adrenalectomy; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects*; D003345:Corticosterone / Q000097:blood / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007375:Interleukin-1 / Q000494:pharmacology*; D008070:Lipopolysaccharides / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008813:Mice, Inbred ICR; D015735:Mifepristone / Q000494:pharmacology; D009929:Organ Size / Q000187:drug effects; D011994:Recombinant Proteins; D012919:Social Behavior; D013950:Thymus Gland / Q000033:anatomy & histology
D007375:Interleukin-1; D008070:Lipopolysaccharides; D011994:Recombinant Proteins; D015735:Mifepristone; D003345:Corticosterone