Status of hepatic glutathione-S-transferase(s) during Plasmodium berghei infection and chloroquine treatment in Mastomys natalensis.
Plasmodium berghei infection in Mastomys natalensis impaired the hepatic mitochondrial, microsomal and cytosolic glutathione-S-transferase(s) activity with 1-chloro-2,4-dinitrobenzene as substrate. The enzyme activity was concomitantly decreased with rise in parasitaemia. The decreased enzyme activity due to infection was almost normalized with oral treatment of 16 mg (kg body wt)-1 of chloroquine for 4 days.
Srivastava
P
P
Division of Biochemistry, Central Drug Research Institute, Lucknow, India.
Arif
A J
AJ
Pandey
V C
VC
D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use*; D003600:Cytosol / Q000201:enzymology; D005982:Glutathione Transferase / Q000378:metabolism*; D008099:Liver / Q000187:drug effects / Q000201:enzymology*; D008288:Malaria / Q000188:drug therapy* / Q000201:enzymology*; D008862:Microsomes, Liver / Q000201:enzymology; D008930:Mitochondria, Liver / Q000201:enzymology; D009115:Muridae; D018512:Parasitemia / Q000201:enzymology; D010962:Plasmodium berghei
D002738:Chloroquine; D005982:Glutathione Transferase