title: Proportion of moderately exercising individuals responding to low-level, multi-hour ozone exposure.
abstract: The purpose of this study was to describe the proportion of moderately exercising individuals experiencing significant respiratory responses to low-level, multi-hour ozone exposure as a function of ozone concentration and exposure duration. Sixty-eight healthy, nonsmoking adults, ages 18 to 34 yr, underwent two or more 6.6-h exposures to 0.0, 0.08, 0.10, or 0.12 ppm ozone. Five hours of exercise was performed during exposure, and lung function was measured before exposure and following each hour of exposure. For each combination of concentration and duration, each individual was determined to either have or not have experienced a 10% or greater decrement in FEV1. A logistic function was used to model the proportion of individuals experiencing such a decrement as a function of concentration and exposure duration. Bootstrap 90% confidence intervals (CIs) were calculated around the predictions. The model was found to give predictions that were in good agreement with observed data. The lowest level of exposure (C x T) for which the 90% CI excluded zero was approximately 0.2 ppm-h. For exposure to 0.12 ppm ozone for 6.6 h, 47% (90% CI = 30 to 65%) of exposed individuals were predicted to experience a 10% decrement in FEV1. A greater proportion of younger adults than of older adults were found to experience a given effect for a given exposure.
authors.affiliation: Clinical Research Branch, U.S. Environmental Protection Agency, Research Triangle Park, NC 27711, USA.
authors.forename: W F
authors.initials: WF
authors.lastname: McDonnell
authors.forename: P W
authors.initials: PW
authors.lastname: Stewart
authors.forename: S
authors.initials: S
authors.lastname: Andreoni
authors.forename: M V
authors.initials: MV
authors.lastname: Smith
mesh_terms: D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000388:Air; D000393:Air Pollutants / Q000008:administration & dosage / Q000009:adverse effects*; D016001:Confidence Intervals; D004305:Dose-Response Relationship, Drug; D005541:Forced Expiratory Volume / Q000187:drug effects; D005544:Forecasting; D006801:Humans; D016015:Logistic Models; D008168:Lung / Q000187:drug effects* / Q000503:physiopathology; D008297:Male; D010126:Ozone / Q000008:administration & dosage / Q000009:adverse effects*; D005082:Physical Exertion / Q000502:physiology*; D013997:Time Factors
chemical_list: D000393:Air Pollutants; D010126:Ozone