title: Correlation between expression of sialosyl-T antigen and survival in patients with gastric cancer.
abstract: Intestinal metaplasia of the gastric mucosa is an important lesion in the pathogenesis of gastric cancer. The expression of a mucin-associated antigen, sialosyl-T antigen, in the tissue of gastric cancer was investigated immunohistochemically to assess its biological role. Sialosyl-T antigen, detected by the monoclonal antibody TKH2, was present in 30 (23.6 per cent) of 127 lesions, and expressed sporadically in intestinal metaplasia. Patients negative for sialosyl-T had a significantly better 5-year survival than those who were positive (70.4 per cent versus 47.2 per cent). Grading by sialosyl-T antigen expression and the DNA ploidy pattern had a predictive value for prognosis in patients with gastric cancer. The biological role of sialosyl-T antigen is not clear but the mucin alteration reflects upon the biological behaviour of gastric cancer.
authors.affiliation: Department of Surgery II, Fukushima Medical College, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Tsuchiya
authors.forename: Y
authors.initials: Y
authors.lastname: Kikuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Ando
authors.forename: R
authors.initials: R
authors.lastname: Abe
mesh_terms: D005500:Follow-Up Studies; D005753:Gastric Mucosa / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D008207:Lymphatic Metastasis; D008679:Metaplasia; D009077:Mucins / Q000378:metabolism*; D011003:Ploidies; D013274:Stomach Neoplasms / Q000378:metabolism* / Q000401:mortality* / Q000473:pathology; D015996:Survival Rate
chemical_list: D009077:Mucins; C087769:sialosyl-T antigen