title: [A controlled multi-centre clinical trial on cisapride in treatment of functional dyspepsia].
abstract: A controlled multi-centre clinical trial was conducted for evaluating the efficacy and safety of cisapride in the treatment of 414 cases of functional dyspepsia with 169 cases as control. Cisapride were given 5mg three times daily for 4 weeks. The results showed that cisapride could significantly improve the symptoms including early satiety, abdominal distention, epigastric pain and nausea. Total efficacy rate of cisapride and placebo were 92.99% and 41.42% respectively. There were statistically significant difference between the two groups. Side-effects are abdominal pain and diarrhoea but most of the patients can endure. The above results indicated that the cisapride was safe and effective in treatment of functional dyspepsia.
authors.affiliation: Beijing Friendship Hospital.
authors.forename: B
authors.initials: B
authors.lastname: Wang
authors.forename: X
authors.initials: X
authors.lastname: Liang
authors.forename: B
authors.initials: B
authors.lastname: Jia
mesh_terms: D015746:Abdominal Pain / Q000139:chemically induced; D000293:Adolescent; D000328:Adult; D000368:Aged; D020117:Cisapride; D003967:Diarrhea / Q000139:chemically induced; D004415:Dyspepsia / Q000188:drug therapy*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010880:Piperidines / Q000009:adverse effects / Q000627:therapeutic use*
chemical_list: D010880:Piperidines; D020117:Cisapride