title: 65Zn uptake by liver of rats fed 3'-methyl-dimethylaminoazobenzene.
abstract: The uptake of 65Zn, determined by gamma-counting and also by autoradiography, significantly increased with the increasing level of metallothionein in liver 4 weeks after the start of feeding a diet containing 3'-methyl-dimethylaminoazobenzene (3'-Me-DAB), at which time the serum gamma-glutamyl transpeptidase activity was not yet significantly elevated. At this time, furthermore, hepatic uptake of 67Ga-citrate did not increase and that of 99mTc-Sn-colloid decreased in 3'-Me-DAB-fed rats. These results suggest that a short-life gamma-emitting isotope such as 69mZn may be useful for the detection at the early stage of hepatic carcinogenesis.
authors.affiliation: Department of Radiobiochemistry, School of Pharmaceutical Sciences, University of Shizuoka, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Takeda
authors.forename: H
authors.initials: H
authors.lastname: Tamano
authors.forename: M
authors.initials: M
authors.lastname: Ohnuma
authors.forename: S
authors.initials: S
authors.lastname: Okada
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001345:Autoradiography; D002712:Chlorides / Q000493:pharmacokinetics; D008099:Liver / Q000378:metabolism*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000175:diagnosis / Q000378:metabolism*; D008297:Male; D008668:Metallothionein / Q000378:metabolism; D051381:Rats; D017208:Rats, Wistar; D014018:Tissue Distribution; D017967:Zinc Compounds / Q000493:pharmacokinetics; D015037:Zinc Radioisotopes / Q000493:pharmacokinetics*; D004124:p-Dimethylaminoazobenzene / Q000633:toxicity*
chemical_list: D002712:Chlorides; D017967:Zinc Compounds; D015037:Zinc Radioisotopes; C016837:zinc chloride; D008668:Metallothionein; D004124:p-Dimethylaminoazobenzene