Angiotensin II regulates nephrogenesis and renal vascular development.
To test the hypothesis that angiotensin II (ANG II) is necessary for normal embryonic and postnatal kidney development, the effect of angiotensin receptor blockade or angiotensin converting enzyme inhibition on nephrovascular development was studied in newborn Sprague-Dawley rats and in Rana catesbeiana tadpoles undergoing prometamorphosis. Blockade of ANG II type 1 receptor (AT1) in newborn rats induced an arrest in nephrovascular maturation and renal growth, resulting in altered kidney architecture, characterized by fewer, thicker, and shorter afferent arterioles, reduced glomerular size and number, and tubular dilatation. Inhibition of ANG II generation in tadpoles induced even more marked developmental renal abnormalities. Blockade of ANG II type 2 receptor (AT2) in newborn rats did not alter renal growth or morphology. Results indicate that ANG II regulates nephrovascular development, a role that is conserved across species.
Tufro-McReddie
A
A
Department of Pediatrics, University of Virginia School of Medicine, Charlottesville 22908, USA.
Romano
L M
LM
Harris
J M
JM
Ferder
L
L
Gomez
R A
RA
D000804:Angiotensin II / Q000494:pharmacology*; D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors / Q000494:pharmacology; D000818:Animals; D000831:Animals, Newborn; D001808:Blood Vessels / Q000187:drug effects / Q000196:embryology / Q000254:growth & development; D004656:Enalapril / Q000494:pharmacology; D007668:Kidney / Q000196:embryology* / Q000254:growth & development*; D007814:Larva; D009399:Nephrons / Q000187:drug effects / Q000196:embryology* / Q000254:growth & development*; D011892:Rana catesbeiana / Q000254:growth & development; D051381:Rats; D017207:Rats, Sprague-Dawley; D012079:Renal Circulation / Q000187:drug effects / Q000502:physiology
D057911:Angiotensin Receptor Antagonists; D000806:Angiotensin-Converting Enzyme Inhibitors; D000804:Angiotensin II; D004656:Enalapril