Magnolol protects human sperm motility against lipid peroxidation: a sperm head fixation method.
It was previously reported that magnolol, isolated from the Chinese medicinal herb Magnolia officinalis, had a potent inhibitory activity on lipid peroxidation. Since sperm motility could be suppressed by lipid peroxidation, this study examines the protective effect of magnolol on lipid peroxidation-suppressed sperm motility. FeSO4 was used to induced lipid peroxidation and sperm motility was expressed as tail beat frequency (TBF) measured with a sperm head fixation method. Magnolol at 10(-9) to 10(-7) M significantly reversed the FeSO4-suppressed TBF. Magnolol significantly inhibited the generation of malondialdehyde (MDA), the end product of lipid peroxidation, in sperm. Magnolol protected sperm motility by inhibiting lipid peroxidation in sperm.
Lin
M H
MH
Institute of Traditional Medicine, National Yang-Ming University Medical College, Taipei, Taiwan, ROC.
Chao
H T
HT
Hong
C Y
CY
D001713:Biphenyl Compounds / Q000008:administration & dosage / Q000494:pharmacology*; D005296:Ferrous Compounds / Q000494:pharmacology; D006801:Humans; D017705:Lignans; D015227:Lipid Peroxidation / Q000187:drug effects*; D008297:Male; D008315:Malondialdehyde / Q000378:metabolism; D013077:Sperm Head / Q000502:physiology*; D013081:Sperm Motility / Q000187:drug effects* / Q000502:physiology; D013094:Spermatozoa / Q000187:drug effects / Q000378:metabolism
D001713:Biphenyl Compounds; D005296:Ferrous Compounds; D017705:Lignans; C005498:magnolol; C020748:ferrous sulfate; D008315:Malondialdehyde