title: New antibiotics phthoxazolins B, C and D produced by Streptomyces sp. KO-7888.
abstract: New antibiotics, phthoxazolins B, C and D were isolated from the fermentation broth of Streptomyces sp. KO-7888. They are geometrical isomers of 10-hydroxyphthoxazolin A. They showed selective antifungal activity against Phytophthora parasitica in vitro and modest herbicidal activity in a laboratory test, but the potencies were different among isomers.
authors.affiliation: Research Center for Biological Function, Kitasato Institute, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Shiomi
authors.forename: N
authors.initials: N
authors.lastname: Arai
authors.forename: M
authors.initials: M
authors.lastname: Shinose
authors.forename: Y
authors.initials: Y
authors.lastname: Takahashi
authors.forename: H
authors.initials: H
authors.lastname: Yoshida
authors.forename: J
authors.initials: J
authors.lastname: Iwabuchi
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: S
authors.initials: S
authors.lastname: Omura
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005233:Fatty Alcohols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D005285:Fermentation; D006540:Herbicides / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D010080:Oxazoles / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013302:Streptomyces; D013329:Structure-Activity Relationship
chemical_list: C095349:10-hydroxyphthoxazolin A; D000935:Antifungal Agents; D005233:Fatty Alcohols; D006540:Herbicides; D010080:Oxazoles