Studies on the inhibitory effects of caffeoylquinic acids on monocyte migration and superoxide ion production.
Three caffeoylquinic acids, isolated from the Peruvian plants Tessaria integrifolia and Mikania cordifolia that are used medicinally as anti-inflammatory agents, were tested for their activities on monocyte migration and superoxide anion production. 3,5-Di-O-caffeoylquinic and 4,5-di-O-caffeoylquinic acids exhibited an appreciable anti-inflammatory activity in vitro, while the tricaffeoyl derivative was inactive.
Peluso
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Istituto di Biochimica delle Proteine ed Enzimologia, Napoli, Italy.
De Feo
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V
De Simone
F
F
Bresciano
E
E
Vuotto
M L
ML
D000595:Amino Acid Sequence; D002478:Cells, Cultured; D002634:Chemotaxis, Leukocyte / Q000187:drug effects*; D006801:Humans; D008969:Molecular Sequence Data; D009000:Monocytes / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D009240:N-Formylmethionine Leucyl-Phenylalanine / Q000494:pharmacology; D010946:Plants, Medicinal / Q000166:cytology; D011801:Quinic Acid / Q000031:analogs & derivatives / Q000302:isolation & purification / Q000494:pharmacology*; D013481:Superoxides / Q000378:metabolism*
D011801:Quinic Acid; D013481:Superoxides; D009240:N-Formylmethionine Leucyl-Phenylalanine