On the origin of a silencer.
Although there are several compelling pieces of evidence suggesting that transcription can promote DNA replication, there are few studies that indicate a role for DNA replication in controlling transcription. Here, we discuss the role of the HMR-E silencer, an origin of replication that plays a crucial role in the regulation of expression of mating-type genes in the yeast Saccharomyces cerevisiae.
Dillin
A
A
Department of Molecular and Cell Biology, University of California, Berkeley 94720, USA.
Rine
J
J
D004261:DNA Replication; D015966:Gene Expression Regulation, Fungal / Q000502:physiology*; D005800:Genes, Fungal; D049770:Genes, Mating Type, Fungal; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D014158:Transcription, Genetic