title: [Heterotopic gray matter: MR findings and clinical aspects].
abstract: Heterotopias are conglomerates of neurons and glial cells in an abnormal location and belong to a group of malformations, which are the result of a disturbed migration of neurons during the embryonic development of the brain. The MRI-appearance and clinical symptoms of 14 patients with nodular or lamellar heterotopias are presented. Seizures were the leading symptom (12 of 14 patients), in children also a developmental deficit (4/10) with or without seizures. Most of the children (9/10) had further brain malformations especially of the corpus callosum or the cerebellar vermis. Nodular heterotopias without further malformations were found in 4 patients, two of them developing grand-mal seizures after childhood. On MRI heterotopias are characterized by a signal isointense to gray matter in all sequences. MRI-scans in at least 2 orientations are necessary to detect these anomalies reliably. MRI is the optimum method for the demonstration of these anomalies and should always be performed if seizures develop during childhood. At least in nodular heterotopias there is no definite correlation between the extent of the anomalies, the EEG-findings and the clinical symptoms. However there is a frequent combination of heterotopias with further cerebral malformations.
authors.affiliation: Institut für klinische Radiologie, Westfälische Wilhelms-Universität, Münster.
authors.forename: G
authors.initials: G
authors.lastname: Schuierer
authors.forename: H
authors.initials: H
authors.lastname: Stefan
authors.forename: D
authors.initials: D
authors.lastname: Wenzel
authors.forename: G
authors.initials: G
authors.lastname: Kurlemann
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D001921:Brain / Q000002:abnormalities / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis*; D002648:Child; D002675:Child, Preschool; D002828:Choristoma / Q000175:diagnosis*; D004830:Epilepsy, Tonic-Clonic / Q000175:diagnosis; D005260:Female; D006801:Humans; D007223:Infant; D007231:Infant, Newborn; D008279:Magnetic Resonance Imaging; D008297:Male; D008875:Middle Aged; D009457:Neuroglia / Q000473:pathology; D009474:Neurons / Q000473:pathology
vernacular_title: Heterotope graue Substanz: MR-Befunde und Klinik.