title: Fine needle aspiration cytology of Tay-Sachs disease. A case report.
abstract: The fine needle aspiration cytology (FNAC) brain findings on a 6-year-old with Tay-Sachs disease are presented. These findings were compared with the FNAC findings on identical areas of a normal brain. Copious material was obtained from both cases. Marked loss of neurons, prominent gliosis, reactive microglia and scattered macrophages were hallmarks of Tay-Sachs disease. The findings were the same as those observed in the histopathology of Tay-Sachs disease. The normal brain, as expected, showed no such changes. It is concluded that FNAC has a great potential for diagnosis and follow-up of Tay-Sachs disease and other nonneoplastic neurologic diseases.
authors.affiliation: Department of Pathology, King Faisal University, Dammam, Saudi Arabia.
authors.forename: A
authors.initials: A
authors.lastname: Ul Haque
mesh_terms: D001707:Biopsy, Needle; D001921:Brain / Q000473:pathology*; D002648:Child; D006801:Humans; D008297:Male; D013661:Tay-Sachs Disease / Q000473:pathology*