title: Fission fragment relative biological effectiveness for liver tumor induction.
abstract: The risk coefficients for liver tumors as derived from 60 beagles with body burdens of 249Cf or 252Cf were used to determine the relative biological effectiveness of fission fragments relative to alpha particles. For liver malignancies the relative biological effectiveness was calculated to be about 2 +/- 3. The estimate based on the combined benign and malignant liver tumors was about 7, with a proportionately larger standard deviation of about +/- 14. Although the confidence intervals were wide, it is possible that the relative biological effectiveness of fission fragments relative to alpha particles, using liver neoplasia as the endpoint, is greater than 1.0 as compared to a value only slightly above zero when bone cancer was the lesion of interest.
authors.affiliation: Radiobiology Laboratory, University of Utah, Salt Lake City 84112, USA.
authors.forename: G N
authors.initials: GN
authors.lastname: Taylor
authors.forename: R D
authors.initials: RD
authors.lastname: Lloyd
authors.forename: C W
authors.initials: CW
authors.lastname: Mays
authors.forename: W
authors.initials: W
authors.lastname: Angus
authors.forename: S
authors.initials: S
authors.lastname: Miller
authors.forename: A
authors.initials: A
authors.lastname: Hubbs
mesh_terms: D000512:Alpha Particles / Q000009:adverse effects; D000818:Animals; D001822:Body Burden; D001859:Bone Neoplasms / Q000209:etiology; D002142:Californium / Q000633:toxicity; D004285:Dogs; D006283:Health Physics; D008114:Liver Neoplasms, Experimental / Q000209:etiology*; D009381:Neoplasms, Radiation-Induced / Q000209:etiology*; D012062:Relative Biological Effectiveness
chemical_list: D002142:Californium