Assessing the effectiveness of X-ray contrast media for abdominal computed tomographic examinations: comparison of four low-osmolality agents.
The objective of this investigation was to assess the effectiveness of four iodinated X-ray contrast media for abdominal computed tomographic (CT) examinations. Fifty-three patients were prospectively randomized to receive iohexol 300 mgI/ml (100 ml, n = 17), ioversol 320 mgI/ml (100 ml, n = 13), iopromide 300 mgI/ml (75 ml, n = 12), or iopentol 300 mgI/ml (100 ml, n = 11) to perform a dynamic contrast-enhanced abdominal CT. Image-enhancement profiles for the liver, aorta, and vena cava were studied. The maximum liver enhancement, the time to maximum liver enhancement, and the area under the hepatic enhancement-time curve (AUC) were determined for each examination. Liver-enhancement profile showed significant differences between the four contrast agents, with lower values for iopromide towards the final part of the CT examination (P < 0.05). Hepatic peak values were attained earlier for iopromide, although these were lower than those produced by any other of the agents evaluated in this study. Iopentol produced fast and intense hepatic peaks. Consequently, high AUC values were obtained with iopentol, low values were obtained with iopromide (P < 0.05), although this can be explained by the lower amount of contrast medium contained in the commercial vial and administered to the patient (75 ml vs 100 ml). When normalized to a 100 ml dose, the AUC value for iopromide becomes even higher than the average of the other three agents (P = 0.05). Ioversol, although available and administered as a more concentrated solution (320 mg/ml), was comparable to the less concentrated iohexol and iopentol (300 mgI/ml).(ABSTRACT TRUNCATED AT 250 WORDS)
Martí-Bonmatí
L
L
Department of Radiology, Hospital Dr Peset, Valencia, Spain.
Ronchera-Oms
C L
CL
Espinós
M A
MA
Jordán
Y
Y
Lucas
A
A
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000704:Analysis of Variance; D001011:Aorta / Q000378:metabolism; D001027:Aortography; D003287:Contrast Media / Q000737:chemistry / Q000493:pharmacokinetics* / Q000592:standards; D005260:Female; D006801:Humans; D007472:Iohexol / Q000031:analogs & derivatives / Q000737:chemistry / Q000493:pharmacokinetics / Q000592:standards; D008099:Liver / Q000000981:diagnostic imaging / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D011446:Prospective Studies; D016037:Single-Blind Method; D014018:Tissue Distribution; D014057:Tomography, X-Ray Computed; D014283:Triiodobenzoic Acids / Q000737:chemistry / Q000493:pharmacokinetics / Q000592:standards; D014684:Venae Cavae / Q000000981:diagnostic imaging / Q000378:metabolism
D003287:Contrast Media; D014283:Triiodobenzoic Acids; D007472:Iohexol; C038192:iopromide; C053571:iopentol; C054871:ioversol