Wortmannin as a unique probe for an intracellular signalling protein, phosphoinositide 3-kinase.
Wortmannin is a fungal metabolite that so far has been shown to act as a selective inhibitor of phosphoinositide 3-kinase. It can therefore be used to investigate the convergence between two major cellular signalling systems: those involving G-protein-coupled receptors and those involving receptor tyrosine kinases. Importantly, wortmannin can enter intact cells, making whole-cell studies of the above signalling pathways possible.
Ui
M
M
Ui Laboratory, Institute of Chemical and Physical Research, Wako-shi, Japan.
Okada
T
T
Hazeki
K
K
Hazeki
O
O
D000730:Androstadienes / Q000494:pharmacology*; D015335:Molecular Probes; D019869:Phosphatidylinositol 3-Kinases; D010716:Phosphatidylinositols / Q000378:metabolism*; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000037:antagonists & inhibitors*; D015398:Signal Transduction / Q000187:drug effects*; D000077191:Wortmannin
D000730:Androstadienes; D015335:Molecular Probes; D010716:Phosphatidylinositols; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D000077191:Wortmannin