title: Organotins are co-clastogens in a whole mammalian system.
abstract: The frequency of micronuclei induced by mitomycin C (MMC) in mouse peripheral reticulocytes was enhanced by treatment with organotins: bis(tri-n-butyltin) oxide (TBTO) and triphenyltin chloride (TPTC). TBTO and TPTC did not themselves induce micronucleated reticulocytes (MNRETs) in mouse peripheral blood. When 50 mg/kg TBTO or 100 mg/kg TPTC was given orally to mice simultaneously with an intraperitoneal (i.p.) administration of 1 mg/kg MMC, however, TBTO and TPTC caused about 55% and 51% increases, respectively, in MMC-induced a synergistic MNRET frequency. Organotin administration 3 or 6 h before and 3 h after MMC injection also caused enhancement of MNRET frequency. These results demonstrate that TBTO and TPTC act as co-clastogens in a whole mammalian system.
authors.affiliation: Biological Laboratory, School of Science, Kwansei Gakuin University, Hyogo, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Yamada
authors.forename: Y F
authors.initials: YF
authors.lastname: Sasaki
mesh_terms: D000818:Animals; D004357:Drug Synergism; D008297:Male; D051379:Mice; D015162:Micronucleus Tests; D016296:Mutagenesis; D009153:Mutagens / Q000633:toxicity*; D009947:Organotin Compounds / Q000633:toxicity*; D012156:Reticulocytes / Q000187:drug effects; D014220:Trialkyltin Compounds / Q000633:toxicity; D014873:Water Pollutants / Q000633:toxicity*
chemical_list: D009153:Mutagens; D009947:Organotin Compounds; D014220:Trialkyltin Compounds; D014873:Water Pollutants; C005961:bis(tri-n-butyltin)oxide; C012594:triphenyltin chloride