title: Time course and inhibition of stavaroside K, veratramine and cevine-induced hemolysis by other pregnane glycosides and Veratrum alkaloids.
abstract: Stavaroside K, veratramine and cevine induce hemolysis, whereas 7 other pregnane stavarosides and 8 Veratrum alkaloids are not hemolytic. On the other hand, erythrocytes pretreated or incubated with low concentrations of stavarosides D-F or with the 8 other Veratrum alkaloids were resistant to hemolysis induced by authentic saponin, stavaroside K, cevine or veratramine. Veratridine, zygadenine and angeloylzygadenine (the known Na-Channel-Gate toxins) revealed the most potent reduction of hemolytic activity.
authors.affiliation: Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Egypt.
authors.forename: F A
authors.initials: FA
authors.lastname: Badria
authors.forename: J D
authors.initials: JD
authors.lastname: McChesney
authors.forename: A F
authors.initials: AF
authors.lastname: Halim
authors.forename: A M
authors.initials: AM
authors.lastname: Zaghloul
authors.forename: K A
authors.initials: KA
authors.lastname: el Sayed
mesh_terms: D002595:Cevanes / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D005960:Glucosides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D011278:Pregnanes / Q000494:pharmacology*; D012503:Saponins / Q000494:pharmacology; D014704:Veratrum Alkaloids / Q000037:antagonists & inhibitors* / Q000494:pharmacology*
chemical_list: D002595:Cevanes; D005960:Glucosides; D011278:Pregnanes; D012503:Saponins; D014704:Veratrum Alkaloids; C095295:stavaroside K; C095294:cevine; C009649:veratramine