Nose drops induce vasomotion in the microcirculation of the sinus mucosa of the rabbit.
Periodic oscillations of blood in the microcirculation of the sinus mucosa in the rabbit were studied with laser-Doppler flowmetry after the application of nose drops (oxymetazoline, xylometazoline and phenylephrine) to the nasal mucosa. All of these drugs induced a dose-dependent decrease in the blood flow in the mucosa. Flowmotion was found in 9 of 21 experiments after an approximately 50% reduction in blood flow had been induced. The concentrations of the drugs which caused vasomotion corresponded to those normally administered as nose drops to man.
Bende
M
M
Department of Applied Mechanics, University of California, San Diego, La Jolla.
Arfors
K E
KE
Intaglietta
M
M
D000281:Administration, Intranasal; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology; D017078:Laser-Doppler Flowmetry; D008297:Male; D008443:Maxillary Sinus / Q000098:blood supply* / Q000187:drug effects*; D008833:Microcirculation / Q000187:drug effects; D009092:Mucous Membrane / Q000098:blood supply / Q000187:drug effects; D014663:Nasal Decongestants / Q000008:administration & dosage / Q000494:pharmacology; D009297:Nasal Mucosa / Q000098:blood supply* / Q000187:drug effects*; D010109:Oxymetazoline / Q000008:administration & dosage / Q000494:pharmacology; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits
D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; D014663:Nasal Decongestants; D010656:Phenylephrine; D010109:Oxymetazoline; C009695:xylometazoline