[Hypogonadotropic form of amenorrhea. Features of the functional state of hypothalamo-hypophyseal structures and the endocrine status].
Study of the function of the hypothalamopituitary system in patients with hypogonadotrophic amenorrhea showed the activity of its structures which manifested by the presence of pulsed LH secretion in 70% of women; however, the parameters of pulsed secretion of gonadotropins were disordered: the pulses were chaotic and low-amplitude. Adenohypophyseal gonadotrophs were capable of reacting to the administered gonadotrophin-releasing hormone, but the parameters of this reaction differed from the normal. The endocrine status of patients with hypogonadotrophic amenorrhea was changed vs. that in health: prolactin level was reduced, growth hormone level increased, thyroid and adrenocortical function changed; the pattern of secretion of some adenohypophyseal trophic hormones (prolactin, STH, TTH) was also changed. The results permit a hypothesis that impairment of the common central mechanisms regulating the endocrine system underlies the development of this disease; basing on their findings, the authors propose new approaches to the correction of this abnormality.
Shchedrina
R N
RN
Nazarenko
T A
TA
Kolod'ko
V G
VG
Fanchenko
N D
ND
Sotnikova
E I
EI
Kiriushkin
A V
AV
Mullabaeva
S M
SM
D000328:Adult; D000568:Amenorrhea / Q000097:blood / Q000503:physiopathology* / Q000628:therapy; D003907:Dexamethasone / Q000627:therapeutic use; D004702:Endocrine Glands / Q000503:physiopathology*; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000627:therapeutic use; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D007986:Luteinizing Hormone / Q000097:blood; D011388:Prolactin / Q000097:blood; D013963:Thyroid Hormones / Q000097:blood
D013963:Thyroid Hormones; D007987:Gonadotropin-Releasing Hormone; D003907:Dexamethasone; D011388:Prolactin; D007986:Luteinizing Hormone; D006854:Hydrocortisone
Gipogonadotropnaia forma amenorei. Osobennosti funktsional'nogo sostoianiia gipotalamo-gipofizarnykh struktur i éndokrinnyĭ status.