Residues 77-95 of the human interleuken-6 protein are responsible for receptor binding and residues 41-56 for signal transduction.
Ehlers
M
M
Department of Biochemistry, Rheinisch-Westfälische Technische Hochshule Aachen, Germany.
Grötzinger
J
J
de Hon
F D
FD
Müllberg
J
J
Brakenhoff
J P
JP
Wollmer
A
A
Rose-John
S
S
D000818:Animals; D015703:Antigens, CD; D001665:Binding Sites; D050822:Cytokine Receptor gp130; D006801:Humans; D015850:Interleukin-6 / Q000737:chemistry* / Q000378:metabolism; D008213:Lymphocyte Activation; D008562:Membrane Glycoproteins / Q000737:chemistry / Q000378:metabolism; D051379:Mice; D018123:Receptors, Interleukin / Q000378:metabolism*; D019947:Receptors, Interleukin-6; D015398:Signal Transduction; D013329:Structure-Activity Relationship
D015703:Antigens, CD; C494199:IL6ST protein, human; C494200:Il6st protein, mouse; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D018123:Receptors, Interleukin; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130