The significance of soluble interleukin-2, soluble interleukin-2 receptors, soluble ICAM-1 and beta 2-microglobulin in breast cancer patients.
The serum levels of soluble interleukin-2 (sIL-2), sIL-2 receptors (sIL-2R), beta 2-microglobulin (beta 2M) and soluble intercellular adhesion molecule-1 (sICAM-1) were measured by the ELISA technique in 129 breast cancer patients and 40 controls. The median serum levels of sIL2-R, beta 2M and sICAM-1 were significantly higher and sIL-2 significantly lower than controls. sIL-2R, sICAM-1 and beta 2M levels were significantly higher in patients with metastatic disease compared to patients on long-term follow-up with no active disease. Initial study measurements of these markers could not identify patients at high risk for relapse. These findings suggest that the sIL-2R level is indicative of metastatic disease and together with other parameters of immune activation may be of help in monitoring disease activity in breast cancer patients.
Klein
B
B
Oncology Unit, Golda Medical Center, Petah Tiqva, Israel.
Levin
I
I
Kfir
B
B
Mishaeli
M
M
Shapira
J
J
Klein
T
T
D000328:Adult; D000368:Aged; D001943:Breast Neoplasms / Q000097:blood*; D006801:Humans; D018799:Intercellular Adhesion Molecule-1 / Q000097:blood*; D007376:Interleukin-2 / Q000378:metabolism*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D015375:Receptors, Interleukin-2 / Q000378:metabolism*; D001613:beta 2-Microglobulin / Q000378:metabolism*
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D001613:beta 2-Microglobulin; D018799:Intercellular Adhesion Molecule-1