title: Effect of trapencaine and some of its derivatives on gastric wall mucus in stressed rats.
abstract: The effect of selected carbanilates on the rat gastric mucus was tested after oral administration. The compounds K 1905 and K 2002 were found to increase gastric mucus content in nonstressed rats while compound P 2 was ineffective. The activity of K 1905 was comparable with that of the parent drug trapencaine. Cold-restraint stress decreased the gastric mucus content and induced haemorrhagic erosions in the glandular stomach. With the exception of compound P 2 pretreatment with carbanilates dose-dependently diminished the extent of stress-induced gastric damage and prevented the depletion of mucus after stress. The results indicate that pentyloxy-substitution in the meta and in the para position on the benzene ring of the parent structure (K 1905 and K 2002, respectively) seems to be more suitable for mucus enhancing activity than alkyloxy-substitution on the para position (P 2). The observed increased mucus secretion might be partly responsible for the gastroprotective action of the drugs tested.
authors.affiliation: Institute of Experimental Pharmacology, Slovak Academy of Sciences, Bratislava.
authors.forename: V
authors.initials: V
authors.lastname: Nosálová
authors.forename: I
authors.initials: I
authors.lastname: Juránek
authors.forename: A
authors.initials: A
authors.lastname: Babulová
mesh_terms: D000779:Anesthetics, Local / Q000494:pharmacology*; D000818:Animals; D002219:Carbamates / Q000494:pharmacology*; D003080:Cold Temperature; D005260:Female; D005753:Gastric Mucosa / Q000187:drug effects / Q000378:metabolism*; D006471:Gastrointestinal Hemorrhage / Q000139:chemically induced; D009093:Mucus / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D051381:Rats; D017208:Rats, Wistar; D012149:Restraint, Physical; D013276:Stomach Ulcer / Q000517:prevention & control; D013315:Stress, Psychological / Q000378:metabolism*; D013329:Structure-Activity Relationship
chemical_list: D000779:Anesthetics, Local; D002219:Carbamates; C010618:pentacaine