[The safety of pyricapirone--a new psychotropic and antiemetic agent].
Acute and chronic toxicities of Pyricapirone, a new psychotropic and antiemetic agent, as a substance and a dosage form (ampoule solution) were studied in experiments on animals (mice, rats, rabbits, and dogs) during various routes of administration (intraperitoneally, subcutaneously, and orally). In terms of acute toxicity, Pyricapirone was found to be low toxic and belongs to toxicity class IV compounds. Pyricapirone showed no accumulative properties. During chronic administration, the agent produced moderate hepatic and renal toxic effects which were reversible; all the detected functional and morphological changes underwent a reversible development during a month rehabilitative period.
Naletov
S V
SV
Kharin
N A
NA
Zin'kovskaia
L Ia
LIa
Obraztsova
O G
OG
D000818:Animals; D014151:Anti-Anxiety Agents / Q000008:administration & dosage / Q000633:toxicity*; D000932:Antiemetics / Q000008:administration & dosage / Q000633:toxicity*; D002065:Buspirone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D002164:Camphor / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D007668:Kidney / Q000187:drug effects; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects; D051379:Mice; D011817:Rabbits; D051381:Rats; D013997:Time Factors
D014151:Anti-Anxiety Agents; D000932:Antiemetics; C085125:pyricapirone; D002164:Camphor; D002065:Buspirone
Bezopasnost' pirikapirona--novogo psikhotropnogo i protivorvotnogo sredstva.