title: Increase in neuronal Jun immunoreactivity and epidermal NGF levels following UV exposure of rat skin.
abstract: Effects of cutaneous ultraviolet (UV) irradiation on superficial nerve fibres are controversial. In the present study we demonstrate by electron microscopy that single high-dose UV exposure of rat skin results in membrane damage in peripheral nerves. Furthermore, a UV-induced accumulation of nerve growth factor (NGF) within the irradiated epidermis and a delayed increase in nuclear Jun immunoreactivity in dorsal root ganglion neurones were detected by immunohistochemistry. Our results suggest that UV-mediated alterations of axonal membranes leads to an activation of Jun transcription factor within affected neurones despite an increase in neurotrophic NGF within their innervation area.
authors.affiliation: II. Physiologisches Institut, Universität Heidelberg, Germany.
authors.forename: F
authors.initials: F
authors.lastname: Gillardon
authors.forename: C
authors.initials: C
authors.lastname: Eschenfelder
authors.forename: R A
authors.initials: RA
authors.lastname: Rush
authors.forename: M
authors.initials: M
authors.lastname: Zimmerman
mesh_terms: D000818:Animals; D005727:Ganglia, Spinal / Q000276:immunology; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D009414:Nerve Growth Factors / Q000378:metabolism*; D010525:Peripheral Nerves / Q000648:ultrastructure; D016755:Proto-Oncogene Proteins c-jun / Q000276:immunology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012867:Skin / Q000378:metabolism; D014466:Ultraviolet Rays
chemical_list: D009414:Nerve Growth Factors; D016755:Proto-Oncogene Proteins c-jun