A new therapeutic approach for sickle cell disease. Blockade of the red cell Ca(2+)-activated K+ channel by clotrimazole.
Brugnara
C
C
Department of Pathology, Children's Hospital, Boston, MA 02115, USA.
De Franceschi
L
L
Armsby
C C
CC
Saadane
N
N
Trudel
M
M
Beuzard
Y
Y
Rittenhouse
A
A
Rifai
N
N
Platt
O
O
Alper
S L
SL
D000284:Administration, Oral; D000755:Anemia, Sickle Cell / Q000188:drug therapy*; D000818:Animals; D002118:Calcium / Q000378:metabolism*; D003022:Clotrimazole / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004195:Disease Models, Animal; D004912:Erythrocytes / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D051379:Mice; D008822:Mice, Transgenic; D026902:Potassium Channel Blockers; D012016:Reference Values
D026902:Potassium Channel Blockers; D003022:Clotrimazole; D002118:Calcium