Influence of bile acid replacement on cyclosporine absorption in a patient with jejunoileal bypass.
Jejunoileal bypass reportedly inhibits the absorption of cyclosporine. In patients with malabsorption syndromes, bile acid replacement has been given to enhance the absorption of cyclosporine. A candidate for heart transplantation with New York Heart Association class IV heart failure and a jejunoileal bypass received cyclosporine alone and with concomitant ursodiol administration to determine whether therapeutic cyclosporine plasma concentrations would be attainable after heart transplantation. There were no differences in peak concentration, time to peak, area under the serum concentration versus time curve, or bioavailability of oral cyclosporine when administered alone or with ursodiol. Plasma cyclosporine concentrations were consistent with those in the general population.
Kino
K J
KJ
University of Washington Medical Center, Department of Pharmacy, Seattle 98195, USA.
Wittkowsky
A K
AK
D016572:Cyclosporine / Q000008:administration & dosage / Q000097:blood / Q000378:metabolism*; D016027:Heart Transplantation; D006801:Humans; D007408:Intestinal Absorption / Q000187:drug effects*; D007581:Jejunoileal Bypass / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D013997:Time Factors; D014580:Ursodeoxycholic Acid / Q000008:administration & dosage / Q000494:pharmacology*
D014580:Ursodeoxycholic Acid; D016572:Cyclosporine