Long-term potentiation and depression in the intermediate gray matter of rat spinal cord in vitro.
Field potentials recorded from a group of cells in the intermediomedial gray matter of spinal cord slices from neonatal rats showed long-term potentiation and long-term depression in response to brief bursts of high frequency conditioning stimulation. Both N-methyl-D-aspartic acid-dependent and N-methyl-D-aspartic acid-independent long-term potentiation was seen. The long-term depression was partially reversed, but not prevented from occurring, by the opiate antagonist naloxone. The frequency of occurrence of long-term potentiation and depression was affected by the inhibitory blockers bicuculline and strychnine in a fashion consistent with the hypothesis that a slight depolarization favoured long-term potentiation and a larger depolarization favoured long-term depression.
Pockett
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Department of Physiology, University of Auckland, New Zealand.
D000818:Animals; D000831:Animals, Newborn; D002478:Cells, Cultured; D003213:Conditioning, Psychological; D004558:Electric Stimulation; D004594:Electrophysiology; D005071:Evoked Potentials / Q000502:physiology*; D066298:In Vitro Techniques; D017774:Long-Term Potentiation; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D011919:Rats, Inbred Strains; D013116:Spinal Cord / Q000502:physiology*; D013997:Time Factors
D009270:Naloxone