title: Cerebellar leptomeningeal astroglial heterotopia in neurofibromatosis type 1.
abstract: Leptomeningeal astroglial heterotopia (LAH) was found in the cerebellum of 2 patients with neurofibromatosis type 1 (NF 1). This LAH was clearly and widely demonstrated with glial fibrillary acidic protein (GFAP) immunohistochemistry and was connected with parenchymal astroglial fibers. These findings suggest that NF 1 involves the dysplasia or overgrowth of astrocytes in the cerebellar leptomeninges.
authors.affiliation: Department of Mental Retardation and Birth Defect Research, National Institute of Neuroscience, Tokyo, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Kato
authors.forename: S
authors.initials: S
authors.lastname: Takashima
authors.forename: S
authors.initials: S
authors.lastname: Houdou
authors.forename: S
authors.initials: S
authors.lastname: Miyahara
mesh_terms: D000293:Adolescent; D001253:Astrocytes / Q000473:pathology*; D001479:Basal Ganglia / Q000473:pathology; D001933:Brain Stem / Q000473:pathology; D002526:Cerebellar Diseases / Q000473:pathology*; D002828:Choristoma / Q000473:pathology*; D006801:Humans; D008297:Male; D008577:Meningeal Neoplasms / Q000473:pathology*; D008875:Middle Aged; D009456:Neurofibromatosis 1 / Q000473:pathology*