Experimental neurocytomas.
Four ethyl-nitrosourea (ENU)-induced oligodendroglioma-like tumors of the rat showing large rosettes on haematoxylin-eosin stain were studied by means of immunohistochemistry and electron microscopy, and their features compared with six human intraventricular neurocytomas. The similarities between the experimental and human tumors studied support the hypothesis that most of the so-called ENU-induced oligodendrogliomas in the rat are primitive neuroectodermal tumors with the tendency to differentiate toward a neuronal phenotype, and also suggest that the ENU-model of neurocarcinogenesis is useful for the induction of experimental neurocytomas.
Vaquero
J
J
Neurosurgical Department, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
Coca
S
S
Zurita
M
M
Oya
S
S
Arias
A
A
Morales
C
C
Buján
J
J
García
N
N
D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000648:ultrastructure; D004801:Eosine Yellowish-(YS); D005038:Ethylnitrosourea; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006416:Hematoxylin; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008854:Microscopy, Electron; D009447:Neuroblastoma / Q000139:chemically induced* / Q000473:pathology / Q000648:ultrastructure; D009837:Oligodendroglioma / Q000139:chemically induced / Q000473:pathology / Q000648:ultrastructure; D016612:Paraffin Embedding; D010641:Phenotype; D051381:Rats; D017208:Rats, Wistar; D016708:Synaptophysin / Q000096:biosynthesis; D014746:Vimentin / Q000378:metabolism
D005904:Glial Fibrillary Acidic Protein; D016708:Synaptophysin; D014746:Vimentin; D005038:Ethylnitrosourea; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin