[Antifungal activity in vitro of Scutellaria baicalensis Georgi upon cutaneous and ungual pathogenic fungi].
The root of Scutellaria baicalensis Georgi (Lamiaceae) is one of the traditional drugs commonly used in the Far East. The extracts obtained by the successive exhaustion in chloroform and in ethyl acetat present clear fungistatic activities in vitro against to some cutaneous and ungual pathogenic fungi, and particularly upon strains of Candida albicans, Cryptococcus neoformans and Pityrosporum ovale. For each of these, its minimum inhibitory concentration is determined. The ethyl acetat extract appears the most interesting because of its efficiency and of its stability. An antifungal substance is found out as the baicalein.
Yang
D
D
Laboratoire de Pharmacie Galénique, Faculté de Médecine et de Pharmacie, Université de Franche-Comté, Besançon.
Michel
D
D
Bevalot
F
F
Chaumont
J P
JP
Millet-Clerc
J
J
D000935:Antifungal Agents / Q000627:therapeutic use; D002855:Chromatography, Thin Layer; D003881:Dermatomycoses / Q000188:drug therapy*; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D044950:Flavanones; D005419:Flavonoids / Q000494:pharmacology; D005658:Fungi / Q000187:drug effects* / Q000472:pathogenicity*; D066298:In Vitro Techniques; D008826:Microbial Sensitivity Tests; D009262:Nails / Q000382:microbiology; D014009:Onychomycosis / Q000188:drug therapy*; D012867:Skin / Q000382:microbiology
D000935:Antifungal Agents; D004365:Drugs, Chinese Herbal; D044950:Flavanones; D005419:Flavonoids; C006680:baicalein
Activité antifongique in vitro de Scutellaria baicalensis Georgi vis-à-vis de champignons pathogènes cutanés et unguéaux.