title: Lymphomatoid papulosis--treatment with recombinant interferon alfa-2a and etretinate.
abstract: Lymphomatoid papulosis is a rare cutaneous lymphoproliferative disorder with nodular, papulonecrotic or plaque-like lesions. Although it is clinically benign, the histology shows large, atypical lymphoid cells that display antigenic markers of activated T-helper lymphocytes and express CD30. There is a close relationship to Hodgkin's disease and to Ki-1-positive anaplastic large-cell lymphoma of the skin. For therapy, various modalities such as PUVA, steroids and acyclovir have been used. We report on a patient with a 10-year history of disease. Treatment with interferon alfa-2a, 3 MU 3 times/week for 4 weeks, and etretinate, 50 mg/day for 5 months, was initially successful, but lesions further relapsed 5 months after cessation of the therapy.
authors.affiliation: Department of Dermatology, University Hospital Zurich, Switzerland.
authors.forename: M
authors.initials: M
authors.lastname: Wyss
authors.forename: R
authors.initials: R
authors.lastname: Dummer
authors.forename: S N
authors.initials: SN
authors.lastname: Dommann
authors.forename: H I
authors.initials: HI
authors.lastname: Joller-Jemelka
authors.forename: M T
authors.initials: MT
authors.lastname: Dours-Zimmermann
authors.forename: F
authors.initials: F
authors.lastname: Gilliet
authors.forename: G
authors.initials: G
authors.lastname: Burg
mesh_terms: D000328:Adult; D001706:Biopsy; D003131:Combined Modality Therapy; D005050:Etretinate / Q000627:therapeutic use*; D006801:Humans; D000077190:Interferon alpha-2; D016898:Interferon-alpha / Q000627:therapeutic use*; D017731:Lymphomatoid Papulosis / Q000188:drug therapy / Q000473:pathology / Q000628:therapy*; D008297:Male; D011994:Recombinant Proteins; D012867:Skin / Q000473:pathology
chemical_list: D000077190:Interferon alpha-2; D016898:Interferon-alpha; D011994:Recombinant Proteins; D005050:Etretinate