Single- and multiple-dose-response relationships of beta-carotene in cystic fibrosis.
Concentrations of carotenoids are low in patients with cystic fibrosis (CF) and are associated with essential fatty acid deficiency and increased markers of inflammation. We conducted single- and multiple-dose studies of beta-carotene supplementation in patients with CF. Dose-proportional increases in beta-carotene concentrations were found, although clearance was independent of dose. Large doses of beta-carotene were necessary to achieve normal plasma levels.
Homnick
D N
DN
Department of Pediatrics, Michigan State University, Kalamazoo Center for Medical Studies 49008, USA.
Spillers
C R
CR
Cox
S R
SR
Cox
J H
JH
Yelton
L A
LA
DeLoof
M J
MJ
Oliver
L K
LK
Ringer
T V
TV
D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000284:Administration, Oral; D000328:Adult; D002338:Carotenoids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002648:Child; D003550:Cystic Fibrosis / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D012044:Regression Analysis; D013997:Time Factors; D019207:beta Carotene
D000276:Adjuvants, Immunologic; D019207:beta Carotene; D002338:Carotenoids