Studies on the antitumor 2,6-piperazinediones: synthesis of 2,3-diacetoxy-4-carbomethoxy-(3',5'-dioxo-N4' substituted piperazinyl methyl) benzene.
The title compounds having the structure of 2,3-diacetoxy-4-carbomethoxy-(3',5'-dioxo-N4'-substituted piperazinyl methyl) benzene were synthesized from 2-hydroxy-3-methoxybenzaldehyde in eight steps. Compound 9h showed a potent inhibitory effect against P388 leukemia cells in vitro.
Li
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Department of Synthetic Chemistry, Shanghai Institute of Materia Medica, Academia Sinica, P.R. of China.
Shao
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HW
Jiang
H L
HL
Xie
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D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D001555:Benzene Derivatives / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D004354:Drug Screening Assays, Antitumor; D006801:Humans; D007941:Leukemia P388 / Q000188:drug therapy; D010879:Piperazines / Q000138:chemical synthesis* / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D001555:Benzene Derivatives; D010879:Piperazines