title: BSH distributions in the canine head and a human patient using 11B MRI.
abstract: A 3D projection reconstruction (3DPR) method was used to obtain in vivo 11B images in a large canine brain tumor model and in a human infused with borocaptate sodium (BSH). Studies were performed in dogs with and without gliosarcomas implanted and grown to a size of 2-3 cm. The 3DPR method demonstrates a signal-to-noise ratio (SNR) that allows qualitative kinetic studies of the boron compound in normal and tumor tissue of the head. The measurements indicate initial uptake of the BSH compound in tumor to be less than that in muscle with no uptake in normal brain tissue. Moreover, uptake of BSH in tissue was found to lag the boron concentration in blood with delays that depend on tissue type. In addition, the first human boron images were obtained on a patient who underwent surgical resection and volumetric debulking of a large (7 cm) glioblastoma multiforme. BSH was readily taken up in residual tumor tissue, while diffusion into the resection volume was slower.
authors.affiliation: Department of Radiology, University of Utah Medical School, Salt Lake City 84132, USA.
authors.forename: K M
authors.initials: KM
authors.lastname: Bradshaw
authors.forename: M P
authors.initials: MP
authors.lastname: Schweizer
authors.forename: G H
authors.initials: GH
authors.lastname: Glover
authors.forename: J R
authors.initials: JR
authors.lastname: Hadley
authors.forename: R
authors.initials: R
authors.lastname: Tippets
authors.forename: P P
authors.initials: PP
authors.lastname: Tang
authors.forename: W L
authors.initials: WL
authors.lastname: Davis
authors.forename: M P
authors.initials: MP
authors.lastname: Heilbrun
authors.forename: S
authors.initials: S
authors.lastname: Johnson
authors.forename: T
authors.initials: T
authors.lastname: Ghanem
mesh_terms: D000818:Animals; D001894:Borohydrides / Q000493:pharmacokinetics; D001895:Boron / Q000493:pharmacokinetics; D016754:Boron Neutron Capture Therapy; D001921:Brain / Q000473:pathology*; D001932:Brain Neoplasms / Q000175:diagnosis*; D004285:Dogs; D005909:Glioblastoma / Q000175:diagnosis*; D018316:Gliosarcoma / Q000175:diagnosis*; D006801:Humans; D007091:Image Processing, Computer-Assisted / Q000379:methods; D007554:Isotopes; D008279:Magnetic Resonance Imaging / Q000379:methods*; D009368:Neoplasm Transplantation; D013438:Sulfhydryl Compounds / Q000493:pharmacokinetics
chemical_list: D001894:Borohydrides; D007554:Isotopes; D013438:Sulfhydryl Compounds; C014651:mercaptoundecahydrododecaborate; D001895:Boron