[The immunomodulating capacity of Shigella flexneri 2A bacteria that have lost their invasiveness plasmid].
An immunosuppressive effect produced by live microbial cells of S. flexneri virulent plasmid-carrying strain 2a 516 (pSF 140-) was shown in relation to the formation of splenic cells producing antibodies to heterologous antigen (sheep red blood cells). This effect was most pronounced at an early period (days 4-7) after the infection of mice. On the contrary, avirulent plasmid-free variant (pSF 140-), genetically related to S. flexneri strain 2a 516, produced an immunostimulating effect at this period of observation. Such immunostimulating action of S. flexneri plasmid-free variant of the smooth type on immunocompetent effector T and B lymphocytes with the preservation of active hematopoiesis is indicative of the possibility of using these variants of shigellae as vector strains in constructing gene engineering (vector) vaccines.
Nikolaeva
T N
TN
Bondarenko
V M
VM
Nastichkin
I A
IA
Romanova
Iu M
IuM
D000818:Animals; D000921:Antibody-Producing Cells / Q000276:immunology; D003114:Colony-Forming Units Assay; D004405:Dysentery, Bacillary / Q000235:genetics / Q000276:immunology / Q000382:microbiology; D006410:Hematopoiesis / Q000235:genetics / Q000276:immunology; D007108:Immune Tolerance / Q000235:genetics / Q000276:immunology; D007111:Immunity, Cellular; D008297:Male; D051379:Mice; D008808:Mice, Inbred CBA; D010957:Plasmids / Q000235:genetics / Q000276:immunology*; D012763:Shigella flexneri / Q000235:genetics / Q000276:immunology* / Q000472:pathogenicity; D013997:Time Factors; D014774:Virulence / Q000235:genetics / Q000276:immunology
Immunomoduliruiushchaia sposobnost' bakteriĭ Shigella flexneri 2A, utrativshikh plazmidu invazivnosti.