TEL1, a gene involved in controlling telomere length in S. cerevisiae, is homologous to the human ataxia telangiectasia gene.
Yeast chromosomes terminate in tracts of simple repetitive DNA (poly[G1-3T]). Mutations in the gene TEL1 result in shortened telomeres. Sequence analysis of TEL1 indicates that it encodes a very large (322 kDa) protein with amino acid motifs found in phosphatidylinositol/protein kinases. The closest homolog to TEL1 is the human ataxia telangiectasia gene.
Greenwell
P W
PW
Department of Biology, University of North Carolina, Chapel Hill 27599-3280, USA.
Kronmal
S L
SL
Porter
S E
SE
Gassenhuber
J
J
Obermaier
B
B
Petes
T D
TD
D002875:Chromosomes / Q000235:genetics / Q000528:radiation effects; D003001:Cloning, Molecular; D005800:Genes, Fungal / Q000235:genetics; D006801:Humans; D008938:Mitosis / Q000235:genetics / Q000528:radiation effects; D008969:Molecular Sequence Data; D009154:Mutation / Q000528:radiation effects; D012441:Saccharomyces cerevisiae / Q000235:genetics*; D017386:Sequence Homology, Amino Acid; D016615:Telomere / Q000235:genetics*