Thymic emigration: conveyor belts or lucky dips?
The thymic medulla has always seemed a rather uncomplicated compartment, simply storing mature thymocytes until they are exported to the peripheral lymphoid organs. However, as discussed here by Roland Scollay and Dale Godfrey, a careful look at recent data suggests that events in the medulla may be more complex and protracted than previously thought.
Scollay
R
R
Centenary Institute of Cancer Medicine and Cell Biology, Sydney, NSW, Australia.
Godfrey
D I
DI
D000818:Animals; D000945:Antigens, Differentiation, T-Lymphocyte / Q000378:metabolism; D001854:Bone Marrow Cells; D002454:Cell Differentiation; D002455:Cell Division; D002465:Cell Movement; D005260:Female; D015329:Gene Rearrangement, T-Lymphocyte; D007700:Kinetics; D051379:Mice; D008822:Mice, Transgenic; D018448:Models, Immunological; D013269:Stochastic Processes; D016176:T-Lymphocyte Subsets / Q000166:cytology* / Q000276:immunology; D013950:Thymus Gland / Q000166:cytology* / Q000196:embryology / Q000254:growth & development
D000945:Antigens, Differentiation, T-Lymphocyte