Observed resistance to pyrimidine analogs and sensitivity to uracil in Drosophila is attributed to deregulation of pyrimidine metabolism.
Piskur
J
J
Department of Genetics, University of Copenhagen, Denmark.
Søndergaard
L
L
Gojkovic
Z
Z
Stokbro
B
B
Hjulsager
C
C
Davidson
J
J
DeMoll
E
E
Rawls
J
J
Bahn
E
E
D000483:Alleles; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D003433:Crosses, Genetic; D004331:Drosophila melanogaster / Q000187:drug effects / Q000235:genetics / Q000378:metabolism*; D005260:Female; D005472:Fluorouracil / Q000494:pharmacology*; D008297:Male; D016296:Mutagenesis; D011743:Pyrimidines / Q000302:isolation & purification / Q000378:metabolism*; D013045:Species Specificity; D014498:Uracil / Q000494:pharmacology*; D014960:X Chromosome
D011743:Pyrimidines; D014498:Uracil; D005472:Fluorouracil