Antinociceptive effect of D-aspartic acid in mice.
The effects of D- and L-aspartic acids on the nociceptive tail flick reflex in mice were investigated. D-Aspartic acid (115-230 mg/kg, IP) was found to increase tail flick latency significantly. Naloxone (0.1 mg/kg) abolished the analgesic effect of D-aspartic acid (115 mg/kg). Morphine and D-aspartic acid, when combined at their nonanalgesic doses, led to significant analgesia. It may be concluded that the opioid system is involved in the antinociceptive effect of D-aspartic acid. Both morphine and D-aspartic acid were previously reported to inhibit L-aspartic acid production via blockade of L-asparaginase. L-Aspartic acid, which was ineffective alone, significantly inhibited the antinociceptive effects of both D-aspartic acid and morphine.
Onat
F
F
Department of Pharmacology, Marmara University School of Medicine, Haydarpaşa, Istanbul, Turkey.
Toker
F
F
Aslan
N
N
Oktay
S
S
Berkman
K
K
D000700:Analgesics / Q000494:pharmacology*; D000818:Animals; D001224:Aspartic Acid / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D005260:Female; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009020:Morphine / Q000037:antagonists & inhibitors / Q000494:pharmacology; D009270:Naloxone / Q000494:pharmacology; D010147:Pain Measurement / Q000187:drug effects; D013997:Time Factors
D000700:Analgesics; D001224:Aspartic Acid; D009270:Naloxone; D009020:Morphine