title: [Kombipek in the therapy of patients with broncho-obstructive lung diseases].
abstract: Bronchodilator combipek of Russian produce was tested in 43 patients with bronchial asthma of various severity. Combipek contains 200 mg of theophylline and 8 mg of salbutamol. Pharmacokinetics of the drug was evaluated after a single administration and upon obtaining equilibrium concentration. Functional and clinical evidence showed a prolonged effect and safety of the drug in long-term treatment of bronchial asthma. Adverse effects emerged in 13 (30.2%) patients. They were typical for theophylline and beta 2-adrenostimulators. Combipek is advocated as a treatment of choice in patients with nocturnal asphyxia, in those who can hardly tolerate large doses of theophylline and beta 2-adrenostimulators.
authors.forename: A G
authors.initials: AG
authors.lastname: Chuchalin
authors.forename: A N
authors.initials: AN
authors.lastname: Tsoĭ
authors.forename: T M
authors.initials: TM
authors.lastname: Zaĭtseva
authors.forename: E V
authors.initials: EV
authors.lastname: Titova
authors.forename: S M
authors.initials: SM
authors.lastname: Medani
authors.forename: M V
authors.initials: MV
authors.lastname: Smirnov
authors.forename: E A
authors.initials: EA
authors.lastname: Kaziakhmedov
mesh_terms: D000328:Adult; D000420:Albuterol / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D001993:Bronchodilator Agents / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D004341:Drug Evaluation; D005260:Female; D006801:Humans; D008173:Lung Diseases, Obstructive / Q000097:blood / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D008875:Middle Aged; D012119:Respiration / Q000187:drug effects; D013806:Theophylline / Q000009:adverse effects / Q000493:pharmacokinetics / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D001993:Bronchodilator Agents; D003692:Delayed-Action Preparations; D004338:Drug Combinations; C095476:theophylline, salbutamol drug combination; D013806:Theophylline; D000420:Albuterol
vernacular_title: "Kombipék" v terapii bol'nykh bronkhoobstruktivnymi zabolevaniiami legkikh.