title: Public health assessment for dioxins exposure from soil.
abstract: Dioxins are among the most toxic anthropogenic chemicals in the environment. Their toxicity has been extensively studied in both humans and animals. Dioxin-contaminated soil may result in dioxins occurring in a food chain. This is especially important for the general population. It has been estimated that about 98% of exposure to dioxins is through the oral route. In the 1980s, a concentration level of 1 ppb 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in soil was specified as "a level of concern," based on cancer effects. However, recent studies indicate that end points other than cancer are also of concern. A health risk analysis scenario based on health effects of TCDD other than cancer is discussed and compared with the projected intake from 1 ppb TCDD in soil.
authors.affiliation: Division of Toxicology, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
authors.forename: H
authors.initials: H
authors.lastname: Pohl
authors.forename: C
authors.initials: C
authors.lastname: DeRosa
authors.forename: J
authors.initials: J
authors.lastname: Holler
mesh_terms: D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D004147:Dioxins / Q000009:adverse effects*; D004781:Environmental Exposure / Q000331:legislation & jurisprudence; D005506:Food Contamination; D017408:Guidelines as Topic; D006801:Humans; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects; D011634:Public Health / Q000592:standards*; D018570:Risk Assessment; D012989:Soil Pollutants / Q000009:adverse effects*; D014481:United States; D014484:United States Environmental Protection Agency; D014486:United States Food and Drug Administration; D014944:World Health Organization
chemical_list: D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants