title: [Amoxicillin and clavulanic acid versus amoxicillin plus gentamicin in the empirical initial treatment of urinary tract infections in hospitalized patients].
abstract: We compared the fixed combination amoxicillin plus clavulanic acid with that of amoxicillin plus gentamicin in the empirical initial treatment of severe urinary tract infections. The study included 87 hospitalized patients (51 women and 36 men, mean age 58 +/- 22 years) with acute uncomplicated pyelonephritis (n = 48) or with complicated urinary tract infections (n = 39). 80 patients (92%) had fever and 31 patients (36%) positive blood cultures. 45 patients were randomly assigned to amoxicillin plus clavulanic acid and 42 to amoxicillin plus gentamicin. Overall, 18 patients (21%) were infected with organisms resistant in vitro to amoxicillin plus clavulanic acid, whereas no pathogen was isolated with resistance to amoxicillin plus gentamicin (p < 0.0001). At the end of the empirical treatment (4.2 +/- 1.5 days after the start), significant bacteriuria was present in 6/39 patients (15%) assigned to amoxicillin plus clavulanic acid, compared to 0/34 patients assigned to amoxicillin plus gentamicin (p < 0.05). The clinical response was satisfactory in both groups, and the time from start of therapy to resolution of fever was 2.2 +/- 1.4 days in the amoxicillin plus clavulanic acid group and 2.3 +/- 1.7 days in the amoxicillin plus gentamicin group. Although the in-vitro resistance did not result in a lower clinical efficacy of amoxicillin plus clavulanic acid compared to amoxicillin plus gentamicin in our relatively small sample of patients, the data indicate that the antimicrobial activity of amoxicillin plus clavulanic acid is inadequate to cover the spectrum of causative agents in hospitalized patients with pyelonephritis or complicated urinary tract infections. Amoxicillin plus clavulanic acid should therefore not be used in the initial empirical treatment of these infections.
authors.affiliation: Reparto di medicina interna, Ospedale regionale di Locarno.
authors.forename: R
authors.initials: R
authors.lastname: Verzasconi
authors.forename: P
authors.initials: P
authors.lastname: Rodoni
authors.forename: R
authors.initials: R
authors.lastname: Monotti
authors.forename: C
authors.initials: C
authors.lastname: Marone
authors.forename: G
authors.initials: G
authors.lastname: Mombelli
mesh_terms: D000328:Adult; D000368:Aged; D000658:Amoxicillin / Q000008:administration & dosage*; D000668:Ampicillin Resistance; D002969:Clavulanic Acids / Q000008:administration & dosage*; D004352:Drug Resistance, Microbial; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D005839:Gentamicins / Q000008:administration & dosage*; D006801:Humans; D007297:Inpatients; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D014552:Urinary Tract Infections / Q000188:drug therapy*
chemical_list: D002969:Clavulanic Acids; D005839:Gentamicins; D000658:Amoxicillin
vernacular_title: Amoxicillin plus Clavulansäure versus Amoxicillin plus Gentamicin in der empirischen Initialbehandlung von Harnwegsinfekten bei Spitalpatienten.