Effect of disease and drug treatment on blood serotonin and monoamine oxidase B activity in Parkinson's disease.
Serotonin (5-hydroxytryptamine, 5HT) content and monoamine oxidase (MAO) activity were determined in whole blood of patients with Parkinson's disease (PD) with and without drug treatment and compared with controls. From that comparison a significant reduction in platelet 5HT became apparent in PD. Selegiline, which was always used in combination with L-dopa, not only inhibited MAO activity, as expected, but it also appeared to induce an increase in 5HT content.
van Kempen
G M
GM
Department of Psychiatry, State University Leiden, Oegstgeest, Netherlands.
Janjua
R
R
Roos
R A
RA
D000328:Adult; D000368:Aged; D000547:Amantadine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D001792:Blood Platelets / Q000187:drug effects; D001971:Bromocriptine / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005260:Female; D006801:Humans; D007980:Levodopa / Q000494:pharmacology* / Q000627:therapeutic use*; D008297:Male; D008875:Middle Aged; D008995:Monoamine Oxidase / Q000378:metabolism*; D010300:Parkinson Disease / Q000188:drug therapy*; D012642:Selegiline / Q000008:administration & dosage / Q000494:pharmacology* / Q000627:therapeutic use*; D012701:Serotonin / Q000378:metabolism*; D016896:Treatment Outcome
D012642:Selegiline; D012701:Serotonin; D001971:Bromocriptine; D007980:Levodopa; D000547:Amantadine; D008995:Monoamine Oxidase