title: [Successful use of a heparinoid (danaparoid sodium) for heparin-induced thrombocytopenia type II in aortic valve reoperation].
abstract: The 29-year-old, heroin-addicted patient received an aortic valve prosthesis (SJM) 10 years ago because of aortic valve stenosis III. One year after surgical treatment he refused to take Phenprocoumon and thus received no anticoagulation for 9 years. The patient was hospitalized due to cardial decompensation and thrombosis of the aortic valve prosthesis was diagnosed. Under heparinization, he developed heparin-induced thrombocytopenia type II, which disappeared after changing the medication to Danaparoid-Sodium. In order to avoid any further heparin exposure, we also carried out the surgical replacement of the aortic valve prosthesis under anticoagulation with Danaparoid-Sodium.
authors.affiliation: Abteilung Innere Medizin I, Universitätsklinik Heidelberg.
authors.forename: E
authors.initials: E
authors.lastname: Scheffler
authors.forename: M
authors.initials: M
authors.lastname: Aulmann
authors.forename: A
authors.initials: A
authors.lastname: Remppis
authors.forename: R
authors.initials: R
authors.lastname: Ziegler
authors.forename: E
authors.initials: E
authors.lastname: Martin
authors.forename: F
authors.initials: F
authors.lastname: Fleischer
authors.forename: P
authors.initials: P
authors.lastname: Nawroth
mesh_terms: D000328:Adult; D001024:Aortic Valve Stenosis / Q000097:blood / Q000601:surgery*; D002809:Chondroitin Sulfates / Q000009:adverse effects / Q000627:therapeutic use*; D003871:Dermatan Sulfate / Q000009:adverse effects / Q000627:therapeutic use*; D004338:Drug Combinations; D006350:Heart Valve Prosthesis; D006493:Heparin / Q000008:administration & dosage / Q000009:adverse effects*; D006497:Heparan Sulfate / Q000009:adverse effects / Q000627:therapeutic use*; D006556:Heroin Dependence / Q000097:blood / Q000150:complications; D006801:Humans; D008297:Male; D010976:Platelet Count / Q000187:drug effects; D011183:Postoperative Complications / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D011475:Prosthesis Failure; D012086:Reoperation; D013921:Thrombocytopenia / Q000097:blood / Q000139:chemically induced* / Q000188:drug therapy; D013927:Thrombosis / Q000097:blood / Q000188:drug therapy*
chemical_list: D002809:Chondroitin Sulfates; D003871:Dermatan Sulfate; D004338:Drug Combinations; D006493:Heparin; D006497:Heparan Sulfate; C035838:danaparoid
vernacular_title: Erfolgreiche Anwendung eines Heparinoids (Danaparoid-Natrium) wegen Heparin-induzierter Thrombozytopenie Typ II bei Aortenklappenreoperation.