The structure-activity relationship of a new anti-arrhythmic agent 1-[2-acetoxy-3-(4-phenyl-1-piperazinyl)propyl]pyrrolidin-2-one.
This paper reports the synthesis of the new compound 1-[2-acetoxy-3-(4-phenyl-1-piperazinyl)propyl]pyrrolidin-2-one (Ac-MG-1). Preliminary pharmacological assessment revealed that Ac-MG-1 possesses anti-arrhythmic activity and a local anesthetic effect. The crystal structure of Ac-MG-1 was determined by X-ray diffraction, and conformational analysis was performed both for Ac-MG-1 and for other derivatives of (arylpiperazinyl)propylpyrrolidin-2-one.
Malawska
B
B
Department of Pharmaceutical Chemistry, Collegium Medicum, Jagiellonian University, Kraków, Poland.
Filipek
B
B
Stadnicka
K
K
Ciechanowicz-Rutkowska
M
M
D000779:Anesthetics, Local / Q000494:pharmacology; D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006224:Cricetinae; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D008968:Molecular Conformation; D011760:Pyrrolidinones / Q000138:chemical synthesis* / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013329:Structure-Activity Relationship
C095640:1-(2-acetoxy-3-(4-phenyl-1-piperazinyl)propyl)pyrrolidin-2-one; D000779:Anesthetics, Local; D000889:Anti-Arrhythmia Agents; D011760:Pyrrolidinones