[Three months oral repeated dose toxicity of T-3761 in beagle dogs].
A three months oral repeated dose toxicity study was carried out in beagle dogs at dosages of 300, 100, 30 and 10 mg/kg, respectively. The following results were obtained. 1. There was no death of animals during administration at any dose levels. A few to all animals in all T-3761 treated groups complained of pain at the time of extension of limbs. 2. Mild decrease of body weight was observed in 1 of the 10 animals at 300 mg/kg and 1 of the 8 animals at 100 mg/kg, respectively. 3. In urinalysis, crystals which seemed to be the test compound in the urinary sediment, were observed in 5 of the 10 animals at 300 mg/kg and 4 of the 8 animals at 100 mg/kg, respectively. 4. In blood biochemical examination, mild elevation of GPT was observed in 1 of the 10 animals at 300 mg/kg. Increase of A/G ratio was observed in males at 300, 100 and 30 mg/kg, and females at all dose levels. 5. In macroscopic findings at necropsy, blister and erosion were observed at articular cartilage of shoulder, elbow, hip, and/or knee joints in all animals at 300 and 100 mg/kg, 7 of the 8 animals at 30 mg/kg and 1 of the 8 animals at 10 mg/kg. 6. No toxic dose level was less than 10 mg/kg/day in this study.
Nakagawa
S
S
Research Laboratories, Toyama Chemical Co., Ltd., Japan.
Nagai
A
A
Nagasawa
M
M
Yoshida
K
K
Iwai
N
N
Sanzen
T
T
Kawamura
Y
Y
Kodama
T
T
D000284:Administration, Oral; D000410:Alanine Transaminase / Q000097:blood; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage* / Q000633:toxicity*; D001835:Body Weight / Q000187:drug effects; D002358:Cartilage, Articular / Q000187:drug effects; D004285:Dogs; D004305:Dose-Response Relationship, Drug; D005260:Female; D024841:Fluoroquinolones; D008297:Male; D010078:Oxazines / Q000008:administration & dosage* / Q000633:toxicity*; D013997:Time Factors
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010078:Oxazines; C078052:pazufloxacin; D000410:Alanine Transaminase