Involvement of CD56/N-CAM molecule in the adhesion of human solid tumor cell lines to endothelial cells.
Tumor-endothelial cell adhesion has been investigated, as this event might represent one of the first steps in the generation of tumor metastasis. We focused our attention on the N-CAM homologous CD56 (besides the CD44, CD15, and CDw49d antigens), as we have recently reported that it can mediate lymphocyte-endothelial cell adhesion [11]. Herein we show that CD56 is involved in tumor cell-endothelial cell binding. This phenomenon is independent of Ca2+ and unlikely to be influenced by the degree of CD56 sialylation.
Zocchi
M R
MR
Laboratory of Immunology, Istituto Scientifico San Raffaele, Milan, Italy.
Vidal
M
M
Poggi
A
A
D015703:Antigens, CD / Q000502:physiology*; D000945:Antigens, Differentiation, T-Lymphocyte / Q000502:physiology*; D019002:CD56 Antigen; D002448:Cell Adhesion / Q000187:drug effects; D015816:Cell Adhesion Molecules, Neuronal / Q000502:physiology*; D004727:Endothelium / Q000502:physiology*; D006801:Humans; D009362:Neoplasm Metastasis; D009439:Neuraminidase / Q000494:pharmacology; D014407:Tumor Cells, Cultured
D015703:Antigens, CD; D000945:Antigens, Differentiation, T-Lymphocyte; D019002:CD56 Antigen; D015816:Cell Adhesion Molecules, Neuronal; D009439:Neuraminidase