[Progress in the study of nerve growth factor family and its receptors].
There were several noticeable progress in the study of the neurotrophic factors, their receptors and the neuronal apoptosis. Firstly, several members of the nerve growth factor family have been identified: NGF, BDNF, NT-3 and NT-4/5. Secondly, the relationship between the three-dimensional structure of the NGF and its function and evolution has been revealed. Thirdly, two kinds of the neurotrophin family receptors were characterized, they are low-affinity NGFR (p75 NGFR) and the trk proto-oncogene product such as p140trkA, p145trkB and p145trkC. Induction of apoptosis by the low-affinity NGFR was also found. Finaly it is possible to use the neurotrophin for treating the degenerative neurological illnesses.
Huang
B R
BR
National Laboratory of Medical Molecular Biology, Peking Union Medical College, Beijing.
Cai
L W
LW
D000595:Amino Acid Sequence; D000818:Animals; D006801:Humans; D008968:Molecular Conformation; D008969:Molecular Sequence Data; D009414:Nerve Growth Factors / Q000737:chemistry / Q000145:classification / Q000502:physiology*; D010300:Parkinson Disease / Q000628:therapy; D000090063:Proto-Oncogene Mas; D017475:Receptors, Nerve Growth Factor / Q000502:physiology*
C000715470:MAS1 protein, human; D009414:Nerve Growth Factors; D000090063:Proto-Oncogene Mas; D017475:Receptors, Nerve Growth Factor