Bone marrow purging with dibutyl phthalate--experimental basis and a preliminary clinical application.
It has been found recently that di-n-butyl phthalate (DBP) possesses a new pharmacological activity in the selective elimination of tumor cells from marrow. In combination with long-term liquid culture of marrow cells in vitro, DBP purged autologous bone marrow transplantation has first been applied to a case of acute myeloid leukemia at the first complete remission with successful reconstitution of hematopoiesis.
Wu
C
C
Department of Experimental Hematology, Beijing Institute of Radiation Medicine, People's Republic of China.
Yang
K
K
Pei
X
X
Tang
A
A
Wang
F
F
Wang
L
L
D000328:Adult; D001854:Bone Marrow Cells; D016465:Bone Marrow Purging / Q000379:methods*; D016026:Bone Marrow Transplantation / Q000379:methods; D003993:Dibutyl Phthalate / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D014182:Transplantation, Autologous
D003993:Dibutyl Phthalate