title: [Treatment of diffused laryngeal and pharyngeal cancer with preoperative radiotherapy in combination with radiation-modifying agents].
abstract: 133 patients with laryngopharyngeal cancer were exposed to preoperative radiation. 4 schemes were used: fractionated long-term radiation alone [1], focused radiation+radiation-modifier metronidazole [2], focused radiation+local hyperthermia (3), focused radiation only (4). It was established that advances in the outcomes can be obtained upon the use of regimen 2 and 3 as recurrence-free survival reached 71% compared to 48-52% in the controls (p < 0.02). No severe postoperative complications were registered.
authors.forename: V G
authors.initials: VG
authors.lastname: Andreev
authors.forename: Iu S
authors.initials: IuS
authors.lastname: Romanko
mesh_terms: D003131:Combined Modality Therapy; D006801:Humans; D006979:Hyperthermia, Induced; D007822:Laryngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D008795:Metronidazole / Q000627:therapeutic use; D010610:Pharyngeal Neoplasms / Q000401:mortality / Q000532:radiotherapy* / Q000601:surgery; D011300:Preoperative Care; D011838:Radiation-Sensitizing Agents / Q000627:therapeutic use*; D011879:Radiotherapy Dosage; D013997:Time Factors
chemical_list: D011838:Radiation-Sensitizing Agents; D008795:Metronidazole
vernacular_title: Lechenie rasprostranennogo raka gortanoglotki s ispol'zovaniem predoperatsionnogo kursa luchevoĭ terapii v sochetanii s radiomodifitsiruiushchimi sredstvami.