title: The amplifying effect of beta-amyloid on cellular calcium signalling is reduced in Alzheimer's disease.
abstract: The amplifying effect of beta-amyloid fragment 25-35 (beta A25-35) on the mitogen-induced rise of free intracellular calcium in circulating lymphocytes was strongly reduced in 24 patients with Alzheimer's disease when compared with elderly, non-demented controls. Low beta-amyloid responses were significantly correlated with the presence of the apolipoprotein E epsilon 4 allele, suggesting a dose effect.
authors.affiliation: Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany.
authors.forename: A
authors.initials: A
authors.lastname: Eckert
authors.forename: H
authors.initials: H
authors.lastname: Förstl
authors.forename: H
authors.initials: H
authors.lastname: Hartmann
authors.forename: C
authors.initials: C
authors.lastname: Czech
authors.forename: U
authors.initials: U
authors.lastname: Mönning
authors.forename: K
authors.initials: K
authors.lastname: Beyreuther
authors.forename: W E
authors.initials: WE
authors.lastname: Müller
mesh_terms: D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001057:Apolipoproteins E / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013997:Time Factors
chemical_list: D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D002118:Calcium