Delayed-type hypersensitivity to human gonadotropin: case report.
OBJECTIVE
To investigate adverse reactions to hMG preparations in two women in IVF programs.


METHODS
Two case reports with skin tests for delayed hypersensitivity (DH) to hMG and a biopsy of one delayed reaction.


METHODS
Allergy and infertility clinics in university medical center.


METHODS
Two affected patents with a history of local reactions to the injected hMG, one of whom also had fever, and nine control subjects.


METHODS
Skin tests and biopsy.


METHODS
Delayed hypersensitivity skin response to hMG in affected patients indicated by timing and biopsy results. Negative skin test with the purified hFSH, which was also used in treatment with no adverse effects.


CONCLUSIONS
Use of the purified preparation avoids DH reaction.
Redfearn
A
A
McMaster University, Hamilton, Ontario, Canada.
Hughes
E G
EG
O'Connor
M
M
Dolovich
J
J
D000328:Adult; D001706:Biopsy; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000276:immunology / Q000302:isolation & purification / Q000627:therapeutic use; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000276:immunology*; D008596:Menotropins / Q000276:immunology* / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D012882:Skin Tests
D008596:Menotropins; D005640:Follicle Stimulating Hormone