title: MRI demonstration of impairment of the blood-CSF barrier by glucose administration to the thiamin-deficient rat brain.
abstract: Contrast-enhanced T1-weighted spin-echo magnetic resonance imaging (MRI) has demonstrated that Gd-diethylenetriaminepentaacetate (Gd-DTPA), which normally does not cross the blood-brain or blood-CSF barriers, does so approximately 40 min after administration of glucose to a vitamin B1 deficient rat. The period of the onset of this blood-CSF or blood-brain barrier dysfunction coincides with our previous observations of accumulation of glutamate or glutamate derivatives following an equivalent glucose load under identical conditions of thiamin deficiency, consistent with a relationship between these two observations. The dysfunction was reversed when a thiamin deficient animal was made thiamin replete.
authors.affiliation: Centre for Magnetic Resonance, University of Queensland, St. Lucia, Brisbane, Australia.
authors.forename: F O
authors.initials: FO
authors.lastname: Zelaya
authors.forename: S E
authors.initials: SE
authors.lastname: Rose
authors.forename: P F
authors.initials: PF
authors.lastname: Nixon
authors.forename: B T
authors.initials: BT
authors.lastname: Wholohan
authors.forename: A J
authors.initials: AJ
authors.lastname: Bower
authors.forename: C
authors.initials: C
authors.lastname: Zimitat
authors.forename: J
authors.initials: J
authors.lastname: Schoutrop
authors.forename: D M
authors.initials: DM
authors.lastname: Doddrell
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000473:pathology; D003287:Contrast Media / Q000493:pharmacokinetics; D005260:Female; D005682:Gadolinium / Q000493:pharmacokinetics; D019786:Gadolinium DTPA; D005947:Glucose / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D004369:Pentetic Acid / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D013832:Thiamine Deficiency / Q000473:pathology / Q000503:physiopathology*; D014899:Wernicke Encephalopathy / Q000503:physiopathology
chemical_list: D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D005947:Glucose; D019786:Gadolinium DTPA