title: The RG2 rat glioma model.
abstract: The ethylnitrosourea-induced cell line RG2 grows very well in infinite cell culture in vitro, and provides a simple, reproducible glioma model when inoculated into the brains of syngeneic Fischer 344 rats. We have used this tumor model in a series of therapy studies. We here report our experiences of the untreated (= tumor bearing control) animals, e.g. in terms of the techniques employed and also the growth, histology and effects upon the blood-brain barrier of the tumors. Weight loss as a measure of systemic effects during tumor development is also described. The RG2 model has considerable potential as a suitable tool for experimental neuro-oncology.
authors.affiliation: Department of Neurosurgery, University Hospital, Lund, Sweden.
authors.forename: A T
authors.initials: AT
authors.lastname: Aas
authors.forename: A
authors.initials: A
authors.lastname: Brun
authors.forename: C
authors.initials: C
authors.lastname: Blennow
authors.forename: S
authors.initials: S
authors.lastname: Strömblad
authors.forename: L G
authors.initials: LG
authors.lastname: Salford
mesh_terms: D000818:Animals; D001812:Blood-Brain Barrier; D001835:Body Weight / Q000502:physiology; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000139:chemically induced / Q000473:pathology*; D017690:Cell Transplantation; D005038:Ethylnitrosourea; D005260:Female; D005910:Glioma / Q000139:chemically induced / Q000473:pathology*; D008297:Male; D009368:Neoplasm Transplantation; D051381:Rats; D011916:Rats, Inbred F344; D012727:Sex Characteristics; D014407:Tumor Cells, Cultured
chemical_list: D005038:Ethylnitrosourea