Effects of buspirone on the immune response to stress in mice.
Several experiments were conducted to evaluate the effects of buspirone, a selective 5-hydroxytryptamine-1A (5-HT1A) anxiolytic, on the immune system of mice exposed to a chronic auditory stressor. Daily injection with 0.5 and 1 mg/kg (intraperitoneally) of buspirone resulted in a dose-dependent reduction in the stress-induced suppression of the natural killer (NK) cell activity and the in vitro and in vivo activity of phagocytosis. Higher doses of buspirone (2.0 mg/kg) showed less robust immunoenhancing effects in stressed mice, and caused a significant suppression of these immune parameters in unstressed mice.
Freire-Garabal
M
M
NIMUS, Department of Pharmacology, School of Pharmacy, University of Santiago de Compostela, Spain.
Nů nez-Iglesias
M J
MJ
Balboa
J L
JL
Fernåndez-Rial
J C
JC
Rey-Mendez
M
M
D000818:Animals; D002065:Buspirone / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D007109:Immunity / Q000187:drug effects*; D066298:In Vitro Techniques; D007694:Killer Cells, Natural / Q000187:drug effects; D008264:Macrophages / Q000187:drug effects; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D009622:Noise / Q000009:adverse effects; D010587:Phagocytosis / Q000187:drug effects; D013154:Spleen / Q000166:cytology / Q000187:drug effects; D013315:Stress, Psychological / Q000276:immunology*
D002065:Buspirone