[Exacerbation of Hailey-Hailey disease by infection with herpes simplex virus. Detection with polymerase chain reaction].
A 49-year-old man suffered from Hailey-Hailey disease for several years. The patient presented with an acute exacerbation of the disease, which did not respond to oral treatment with high doses of glucocorticosteroids. A skin biopsy was taken and the histological examination indicated a viral infection. Herpes simplex virus was confirmed by electron microscopy (negative staining) and polymerase chain reaction (PCR). The PCR presents a sensitive and effective molecular-biological method for the diagnosis of viral infections.
Schirren
H
H
Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, München.
Schirren
C G
CG
Schlüpen
E M
EM
Volkenandt
M
M
Kind
P
P
D001706:Biopsy; D004279:DNA, Viral / Q000302:isolation & purification; D006558:Herpes Genitalis / Q000175:diagnosis* / Q000473:pathology; D006561:Herpes Simplex / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D016506:Pemphigus, Benign Familial / Q000175:diagnosis* / Q000473:pathology; D010409:Penile Diseases / Q000175:diagnosis* / Q000473:pathology; D016133:Polymerase Chain Reaction; D012867:Skin / Q000473:pathology
D004279:DNA, Viral
Exazerbation eines Morbus Hailey-Hailey durch Infektion mit Herpes-simplex-Virus. Nachweis mittels Polymerasekettenreaktion.