[The detection of the genotoxic and mutagenic activities of disperse azo dyes for their hygienic standardization].
Evaluating level and synthesis of DNA in liver cells, counting occurrence of dominant lethal mutations, the authors studied molecular and genetic effects of dispersed polyaether mononitrodyes Orange 2K and Red-Brown G after the peroral administration and the chronic inhalation (2.5 and 4 months). Red-Brown G examined in acute and chronic exposures appeared to be powerful mutagen. Orange 2K induced minor changes of nuclear DNA functioning in liver cells, if compared to Red-Brown G. In Dominant Lethal Mutations Test both dyes were assigned to mild mutagens. The diagnosed effects are used for setting hygienic standards in the air of workplace.
Palagina
I A
IA
Deveĭkis
D N
DN
Vashchuk
N A
NA
Kaliuzhnyĭ
G L
GL
D000395:Air Pollutants, Occupational / Q000633:toxicity; D000818:Animals; D001391:Azo Compounds / Q000633:toxicity*; D004396:Coloring Agents / Q000633:toxicity*; D004247:DNA / Q000096:biosynthesis / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D005799:Genes, Dominant / Q000187:drug effects*; D005808:Genes, Recessive / Q000187:drug effects*; D008099:Liver / Q000187:drug effects; D008297:Male; D008452:Maximum Allowable Concentration; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D051381:Rats; D013997:Time Factors
D000395:Air Pollutants, Occupational; D001391:Azo Compounds; D004396:Coloring Agents; D009153:Mutagens; C095593:disperse orange 25; C095594:disperse red 118; D004247:DNA
Vyiavlenie genotoksicheskoĭ i mutagennoĭ aktivnosti dispersnykh azokrasiteleĭ s tsel'iu ikh gigienicheskogo normirovaniia.