title: Neonatal leukocyte cAMP-phosphodiesterase determination is not suitable for allergy prediction.
abstract: The atopy-predictive value of cord blood (CB) cyclic adenosine monophosphate-phosphodiesterase (cAMP-PDE) in mononuclear leukocytes (MN) was studied prospectively in 57 neonates. Reliable determination of cAMP-PDE was achieved in only 20 CB samples. The levels tended to be higher in infants developing signs of atopy up to 18 months of age. The combination of CB cAMP-PDE and family history (FH) of allergy showed a higher predictive value (P = 0.040) than each of them separately (P = 0.370 and P = 0.102, respectively). The cAMP-PDE levels in CB also correlated to FH of allergy/atopy in accordance with earlier studies (P = 0.027). In conclusion, determination of cAMP-PDE in neonates may have some predictive value, but it is not suitable for general screening.
authors.affiliation: Department of Pediatrics, University Hospital, Linköping, Sweden.
authors.forename: H
authors.initials: H
authors.lastname: Odelram
authors.forename: B
authors.initials: B
authors.lastname: Björkstén
authors.forename: S C
authors.initials: SC
authors.lastname: Chan
authors.forename: J M
authors.initials: JM
authors.lastname: Hanifin
authors.forename: N I
authors.initials: NI
authors.lastname: Kjellman
mesh_terms: D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000097:blood*; D004198:Disease Susceptibility; D005312:Fetal Blood / Q000737:chemistry*; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000175:diagnosis* / Q000235:genetics; D007231:Infant, Newborn; D007962:Leukocytes / Q000737:chemistry*; D011237:Predictive Value of Tests; D011446:Prospective Studies
chemical_list: D015105:3',5'-Cyclic-AMP Phosphodiesterases