title: Nitric oxide synthase activities in human myocardium.
abstract: Myocardial constitutive and inducible nitric oxide (NO) synthase activities were measured in right ventricular tissue from 17 patients with dilated cardiomyopathy (DCM). A significant activity of inducible enzyme was accompanied by a low activity of the constitutive NO synthase. Thus, the myocardium has the capacity to express both NO synthases. NO may have a physiological as well as a pathological role in the human myocardium.
authors.affiliation: Department of Cardiology, King's College Hospital, London, UK.
authors.forename: A J
authors.initials: AJ
authors.lastname: de Belder
authors.forename: M W
authors.initials: MW
authors.lastname: Radomski
authors.forename: H J
authors.initials: HJ
authors.lastname: Why
authors.forename: P J
authors.initials: PJ
authors.lastname: Richardson
authors.forename: C A
authors.initials: CA
authors.lastname: Bucknall
authors.forename: E
authors.initials: E
authors.lastname: Salas
authors.forename: J F
authors.initials: JF
authors.lastname: Martin
authors.forename: S
authors.initials: S
authors.lastname: Moncada
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002311:Cardiomyopathy, Dilated / Q000201:enzymology*; D004790:Enzyme Induction; D006801:Humans; D009206:Myocardium / Q000201:enzymology*; D019001:Nitric Oxide Synthase; D051381:Rats
chemical_list: D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D002118:Calcium