title: Oxygen effect on O2 deficit and VO2 kinetics during exercise in obstructive pulmonary disease.
abstract: We evaluated the effect of supplemental O2 on energy metabolism of hypoxemic humans by measuring O2 uptake (VO2) kinetics and other cardiorespiratory parameters in nine male chronic obstructive pulmonary disease (COPD) patients and seven age-matched control subjects (on air and on 30% O2) at rest and during moderate cycle ergometer exercise. Heart rate, ventilation, VO2, CO2 output, respiratory exchange ratio, O2 cost of work, and work efficiency were measured with a computerized metabolic cart; O2 deficit and VO2 time courses were calculated. In COPD patients, 30% O2 breathing resulted in 1) reduction of O2 deficit (from 488 +/- 34 ml in air to 398 +/- 27 ml in O2; P < 0.05) and phase 2 VO2 time constant (from 116 +/- 13 s in air to 74 +/- 12 s in O2; P < 0.05); 2) a smaller steady-state increment in CO2 output than in room air (315 +/- 17 ml/min in O2 vs. 358 +/- 27 ml/min in air; P < 0.02), which resulted in a lower exercise respiratory exchange ratio (0.75 +/- 0.02 in O2 vs. 0.80 +/- 0.02 in air; P < 0.02); and 3) reduced steady-state ventilation (22.6 +/- 1.0 l/min in O2 vs. 25.4 +/- 1.1 l/min in air; P < 0.05). In conclusion, 30% O2 breathing accelerated exercise VO2 kinetics in mildly hypoxemic COPD patients. The observed VO2 kinetics improvement with O2 supplementation is consistent with an enhancement of aerobic metabolism in skeletal muscles during moderate exercise.
authors.affiliation: II Patologia Medica, La Sapienza University Medical School, Rome, Italy.
authors.forename: P
authors.initials: P
authors.lastname: Palange
authors.forename: P
authors.initials: P
authors.lastname: Galassetti
authors.forename: E T
authors.initials: ET
authors.lastname: Mannix
authors.forename: M O
authors.initials: MO
authors.lastname: Farber
authors.forename: F
authors.initials: F
authors.lastname: Manfredi
authors.forename: P
authors.initials: P
authors.lastname: Serra
authors.forename: S
authors.initials: S
authors.lastname: Carlone
mesh_terms: D000368:Aged; D002245:Carbon Dioxide / Q000378:metabolism; D015444:Exercise; D006801:Humans; D007700:Kinetics; D008173:Lung Diseases, Obstructive / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000378:metabolism*; D012123:Pulmonary Ventilation; D013997:Time Factors
chemical_list: D002245:Carbon Dioxide; D010100:Oxygen