Cross-resistance to thymidylate synthase inhibitors in P-glycoprotein and non-P-glycoprotein cell lines.
van Triest
B
B
Free University Hospital, Department of Medical Oncology, Amsterdam, The Netherlands.
Telleman
F
F
Pinedo
H M
HM
van der Wilt
C L
CL
Peters
G J
GJ
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1 / Q000378:metabolism*; D000964:Antimetabolites, Antineoplastic / Q000633:toxicity*; D002294:Carcinoma, Squamous Cell; D002453:Cell Cycle / Q000187:drug effects; D002460:Cell Line; D002999:Clone Cells; D004317:Doxorubicin / Q000378:metabolism / Q000633:toxicity*; D018432:Drug Resistance, Multiple; D005468:Fluorodeoxyuridylate / Q000378:metabolism; D005472:Fluorouracil / Q000633:toxicity; D006801:Humans; D008175:Lung Neoplasms; D011799:Quinazolines / Q000633:toxicity; D013876:Thiophenes / Q000633:toxicity; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors* / Q000378:metabolism; D014407:Tumor Cells, Cultured
D020168:ATP Binding Cassette Transporter, Subfamily B, Member 1; D000964:Antimetabolites, Antineoplastic; D011799:Quinazolines; D013876:Thiophenes; D005468:Fluorodeoxyuridylate; D004317:Doxorubicin; D013940:Thymidylate Synthase; C068874:raltitrexed; D005472:Fluorouracil