Burkitt translocation (8;22)(q24;q11) in a patient with multiple myeloma.
The prevalence of chromosomal abnormalities in multiple myeloma (MM) has been difficult to detect by karyotyping primarily because of the low proliferative rate of malignant plasma cells. The reported incidences of abnormal karyotypes range from 24% to 63% in bone marrows obtained from MM patients, with the higher rates being seen in aggressive disease [1-8]. Detection of abnormal karyotypes in MM has been associated with a poor prognosis. We report a MM patient with an 8;22 Burkitt translocation, the first such reported case.
Look
R M
RM
Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Lim
S W
SW
Schreck
R R
RR
Lee
S
S
Fuerst
M P
MP
Lawrence
G N
GN
Kusuanco
D A
DA
Kessler
C E
CE
Giles
F J
FJ
D001853:Bone Marrow / Q000648:ultrastructure; D002892:Chromosomes, Human, Pair 22; D002898:Chromosomes, Human, Pair 8; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics*; D014178:Translocation, Genetic