title: Hematological parameters influencing the Thrombostat 4000.
abstract: The effects of platelet counts, hematocrit, and leukocyte counts were studied on the closure times of the Thrombostat 4000 (in-vitro bleeding time, IVBT). Closure times became longer with platelet counts < 50 x 10(9)/L; an inverse linear correlation could be established. Hematocrit was also inversely correlated with the closure time. At constant platelet counts a hematocrit of 55% yielded an immediate closure of the filter, while with a hematocrit < 15% no closure times could be measured. At constant platelet counts and hematocrits, nomonuclear and polymorphonuclear leukocytes also influenced closure times; increased counts resulted in shorter closure times. Leukocytes from a patient with chronic myelocytic leukemia had the same effects.
authors.affiliation: Department of Internal Medicine, Heinrich-Heine-University, Düsseldorf, Germany.
authors.forename: D
authors.initials: D
authors.lastname: Söhngen
authors.forename: E
authors.initials: E
authors.lastname: Hattstein
authors.forename: A
authors.initials: A
authors.lastname: Heyll
authors.forename: G
authors.initials: G
authors.lastname: Meckenstock
authors.forename: S
authors.initials: S
authors.lastname: Wienen
authors.forename: W
authors.initials: W
authors.lastname: Schneider
mesh_terms: D001760:Bleeding Time; D001780:Blood Coagulation Tests / Q000295:instrumentation* / Q000592:standards; D006400:Hematocrit; D006801:Humans; D007958:Leukocyte Count; D010976:Platelet Count; D011517:Prothrombin Time