Insulin resistance in a patient with ovarian stromal hyperthecosis and the hyperandrogenism, insulin resistance and acanthosis nigricans syndrome. Report of a case with a possible endogenous ovarian factor.
Insulin resistance is a common feature of ovarian stromal hyperthecosis and is usually accompanied by hyperandrogenemia. A patient had ovarian stromal hyperthecosis, and her hyperandrogenemia resolved, possibly due to the development of a type of ovarian fibrosis similar to so-called ovarian fibromatosis, without a concomitant improvement in her insulin resistance. The insulin resistance improved markedly, however, after bilateral oophorectomy.
Mantzoros
C S
CS
Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan 48201, USA.
Lawrence
W D
WD
Levy
J
J
D000052:Acanthosis Nigricans / Q000473:pathology / Q000503:physiopathology*; D000328:Adult; D005260:Female; D006801:Humans; D017588:Hyperandrogenism / Q000473:pathology / Q000503:physiopathology*; D007333:Insulin Resistance; D010053:Ovary / Q000473:pathology*; D013577:Syndrome