Significance of aminopyrine breath test as a parameter of hepatic functional reserve in 40% partial hepatectomy of rats with CCl4-induced liver injury.
Rats with CCl4-induced liver injury underwent partial (40%) hepatectomy. The [14C]aminopyrine breath test (ABT) values in rats with CCl4-induced liver injury were reduced by 34% compared with those in rats with normal liver. Preoperative ABT values clearly discriminated between survivors and those that died following 40% partial hepatectomy in rats CCl4-induced liver injury (P < 0.05). Hepatic protein synthesis was remarkably enhanced in CCl4-induced liver injury compared with normal liver (P < 0.001), and this was inversely correlated with ABT values (P < 0.001). These data show that the enhanced hepatic protein synthesis could induce a decrease of hepatic functional reserve. ABT seems to be a useful preoperative test for predicting surgical mortality following hepatectomy.
Miyazaki
M
M
1st Department of Surgery, School of Medicine, Chiba University, Japan.
Sugasawa
T
T
Itoh
H
H
Kaiho
T
T
Ando
K
K
Anbiru
S
S
Ohtawa
S
S
Ogata
A
A
Yasuda
N
N
Hayashi
S
S
D000410:Alanine Transaminase / Q000378:metabolism; D000632:Aminopyrine; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001944:Breath Tests; D002251:Carbon Tetrachloride; D006498:Hepatectomy; D008099:Liver / Q000502:physiology*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D008111:Liver Function Tests; D008297:Male; D014176:Protein Biosynthesis; D051381:Rats; D017208:Rats, Wistar
D000632:Aminopyrine; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase