Linkage of a gene for dominant non-syndromic deafness to chromosome 19.
Inherited hearing impairment can occur either in the presence of other clinical features (syndromic hearing loss, SHL) or in isolation (non-syndromic hearing loss, NSHL). The latter is more common and is highly heterogeneous. To date, six NSHL loci have been mapped. We report the identification of a seventh locus (DFNA4) on chromosome 19q13 and suggest DM kinase as a possible candidate gene.
Chen
A H
AH
Department of Otolaryngology, University of Iowa, Iowa City 52242, USA.
Ni
L
L
Fukushima
K
K
Marietta
J
J
O'Neill
M
M
Coucke
P
P
Willems
P
P
Smith
R J
RJ
D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D003638:Deafness / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D065636:Myotonin-Protein Kinase; D010375:Pedigree; D017346:Protein Serine-Threonine Kinases / Q000235:genetics
C585517:DMPK protein, human; D065636:Myotonin-Protein Kinase; D017346:Protein Serine-Threonine Kinases