[Damage to condoms caused by vaginally administered drug].
A 28-year-old woman who was treated for vaginal candidiasis with Gyno-Daktarin vaginal capsules (miconazole nitrate) became pregnant because a condom used during intercourse had ruptured. Incubation in vitro with 400 and 1200 mg miconazole nitrate vaginal capsules (Gyno-Daktarin 3 and Gyno-Daktarin I), but not miconazole nitrate vaginal cream (20 mg/g), was shown to damage rubber condoms. Patients using vaginal medicines should be aware of a possible adverse effect on rubber condoms or contraceptive diaphragms and a subsequent increased risk of pregnancy or contagious diseases such as AIDS. Fatty excipients such as glycerin, paraffin, petrolatum or Witepsol may be involved.
Meyboom
R H
RH
Stichting Landelijke Registratie Evaluatie Bijwerkingen, Tilburg.
Havinga
J S
JS
Lastdrager
C J
CJ
de Koning
G H
GH
D000282:Administration, Intravaginal; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy; D003274:Contraceptive Devices, Female / Q000592:standards*; D005260:Female; D006801:Humans; D008825:Miconazole / Q000008:administration & dosage* / Q000009:adverse effects
D000935:Antifungal Agents; D008825:Miconazole
Beschadiging van condooms door vaginaal toegediende geneesmiddelen.