title: Analysis of trichloroacetic acid in the urine of workers occupationally exposed to trichloroethylene by capillary gas chromatography.
abstract: A gas chromatographic procedure is described for the determination of trichloroacetic acid in urine, the major metabolite of trichloroethylene exposure. Trichloroacetic acid was derivatised to its methyl ester with BF3/methanol reagent and then extracted into toluene and analysed by capillary gas chromatography using electron-capture detection. The response was linear in the range 0.4-100 mg/l of trichloroacetic acid in urine and showed a relative recovery of 99.6%. The procedure is suitable for monitoring occupational exposure to trichloroethylene.
authors.affiliation: Laboratory Services, WorkCover Authority of N.S.W., Thornleigh, Australia.
authors.forename: G E
authors.initials: GE
authors.lastname: O'Donnell
authors.forename: A
authors.initials: A
authors.lastname: Juska
authors.forename: R
authors.initials: R
authors.lastname: Geyer
authors.forename: M
authors.initials: M
authors.lastname: Faiz
authors.forename: S
authors.initials: S
authors.lastname: Stalder
mesh_terms: D000042:Absorption; D002197:Capillary Action; D002849:Chromatography, Gas / Q000379:methods* / Q000706:statistics & numerical data; D006801:Humans; D016273:Occupational Exposure; D012680:Sensitivity and Specificity; D014238:Trichloroacetic Acid / Q000652:urine*; D014241:Trichloroethylene / Q000493:pharmacokinetics*
chemical_list: D014241:Trichloroethylene; D014238:Trichloroacetic Acid