title: Sequential steps in axonal targeting are mediated by carbohydrate markers.
abstract: Mannose and hybrid/complex-type oligosaccharides serve as markers for both the full set of peripheral sensory afferent neurons in the leech and also for disjoint subsets of these neurons. We have shown that these various surface carbohydrates play crucial roles in the multistep process by which afferents meet their synaptic partners in the central nervous system (CNS). The carbohydrate marker common to all these afferents allows their projections (which are fasciculated as they enter the CNS) to disperse and search out target regions. Carbohydrate markers specific for subsets of these afferents subsequently allow each subset to consolidate the position of its projections in appropriate regions of the CNS where it contacts its synaptic partners.
authors.affiliation: Department of Physiology, Michigan State University, East Lansing 48824, USA.
authors.forename: B
authors.initials: B
authors.lastname: Zipser
mesh_terms: D000818:Animals; D001369:Axons / Q000502:physiology*; D015415:Biomarkers; D002241:Carbohydrates / Q000502:physiology*; D007865:Leeches / Q000254:growth & development* / Q000502:physiology*; D009420:Nervous System / Q000254:growth & development*; D009424:Nervous System Physiological Phenomena
chemical_list: D015415:Biomarkers; D002241:Carbohydrates