[The activity of the phagocytic bactericidal systems in intact guinea pigs and in guinea pigs immunized against tularemia].
The activities of NADP-oxidase and glucose-6-phosphate dehydrogenase in mononuclear phagocytes and polymorphonuclear leukocytes (PML) during the phagocytosis of Francisella tularensis and the influence of immunization of on the activity of oxygen-dependent metabolism were studied. The phagocytosis of F.tularensis was found to be accompanied by a rise in the activity of NADP.H-oxidase and glucose-6-phosphate dehydrogenase. In the process of immunogenesis the rearrangement of the enzymatic system ensuring the antimicrobial action of phagocytes occurred. Macrophages exhibited higher enzymatic activity than PML.
Golubinskiĭ
E P
EP
Boĭkova
I S
IS
Dubrovina
V I
VI
D000818:Animals; D001770:Blood Bactericidal Activity / Q000276:immunology*; D005604:Francisella tularensis; D005954:Glucosephosphate Dehydrogenase / Q000097:blood; D006168:Guinea Pigs; D007114:Immunization; D007963:Leukocytes, Mononuclear / Q000201:enzymology / Q000276:immunology; D009247:NADH, NADPH Oxidoreductases / Q000097:blood; D019255:NADPH Oxidases; D009504:Neutrophils / Q000201:enzymology / Q000276:immunology; D010586:Phagocytes / Q000201:enzymology / Q000276:immunology*; D010587:Phagocytosis / Q000276:immunology; D014406:Tularemia / Q000201:enzymology / Q000276:immunology* / Q000517:prevention & control
D005954:Glucosephosphate Dehydrogenase; D009247:NADH, NADPH Oxidoreductases; D019255:NADPH Oxidases
Aktivnost' bakteritsidnykh sistem fagotsitov u intaktnykh i immunizirovannykh protiv tuliaremii morskikh svinok.