[Interleukin-2 activity in monocrotaline-treated rat lungs].
To study the relationship between cytokines and the development of monocrotaline-induced pulmonary hypertension, monocrotaline was given and interleukin-2 was measured. The amount of interleukin-2 produced by pulmonary cells obtained by bronchoalveolar lavage was high only on the 14th day after monocrotaline injection (p < 0.01). This suggests that many kinds of cells in the monocrotaline-treated rat lung were activated by cytokines, and that these interactions play an important role in the development of monocrotaline-induced pulmonary hypertension in rats.
Suzuki
A
A
Department of Chest Medicine, School of Medicine, Chiba University.
Kakusaka
I
I
Kiyatake
K
K
Nakano
K
K
Kaneko
N
N
Kuriyama
T
T
D000818:Animals; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000276:immunology*; D007376:Interleukin-2 / Q000378:metabolism*; D008168:Lung / Q000166:cytology / Q000378:metabolism*; D008297:Male; D016686:Monocrotaline; D051381:Rats; D017207:Rats, Sprague-Dawley
D007376:Interleukin-2; D016686:Monocrotaline