title: Urinary concentration of a specific peptide of type I collagen of bone (CrossLaps): correlation to hydroxyproline.
abstract: Urinary bone resorption markers, CrossLaps and hydroxyproline are compared in a non-selected group of 93 women. The correlation between CrossLaps and hydroxyproline is satisfactory. The r value is 0.79. Furthermore, it is investigated whether CrossLaps can substitute for hydroxyproline in the estimation of bone loss, using a model based on the combination of several biochemical markers. The results indicate that the two systems reflect related or parallel events, and show that CrossLaps is suitable for use in a normal clinical chemistry laboratory.
authors.affiliation: Department of Clinical Chemistry, Telemark Central Hospital, Porsgrunn, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Silsand
authors.forename: A
authors.initials: A
authors.lastname: Reine
authors.forename: S
authors.initials: S
authors.lastname: Dugal
authors.forename: T
authors.initials: T
authors.lastname: Lunde
authors.forename: B
authors.initials: B
authors.lastname: Smedsrud
authors.forename: T
authors.initials: T
authors.lastname: Seeberg
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001842:Bone and Bones / Q000737:chemistry*; D003094:Collagen / Q000652:urine*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D007118:Immunoassay; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000652:urine; D010455:Peptides / Q000652:urine; D012680:Sensitivity and Specificity
chemical_list: D015415:Biomarkers; D010455:Peptides; D003094:Collagen; D006909:Hydroxyproline