A recipe for specificity.
Water molecules and DNA conformation are now recognized as ingredients which can influence both the affinity and specificity of protein/DNA complexes.
Arbuckle
N D
ND
Luisi
B
B
D000595:Amino Acid Sequence; D001483:Base Sequence; D001665:Binding Sites; D017124:Conserved Sequence; D004247:DNA; D004268:DNA-Binding Proteins / Q000737:chemistry*; D008958:Models, Molecular; D008969:Molecular Sequence Data; D009690:Nucleic Acid Conformation; D013816:Thermodynamics; D014867:Water / Q000737:chemistry
D004268:DNA-Binding Proteins; D014867:Water; D004247:DNA