Sphero-echinocytosis of human red blood cells caused by snake, red-back spider, bee and blue-ringed octopus venoms and its inhibition by snake sera.
It was found that bee (Apis mellifera) venom, red-back spider (Latrodectus mactans) venom, blue-ringed octopus (Hapalochlaena maculosa) venom, ten different snake venoms, phospholipase A2 and four snake toxins caused sphero-echinocytosis of human red blood cells at 200 ng/ml. Most venoms and toxins lost the ability to deform human red blood cells when their components of less than mol. wt 10,000 were applied. In a number of cases the sphero-echinocytotic effect was also inhibited by blood sera of Notechis scutatus and Pseudonaja textilis.
Flachsenberger
W
W
Department of Physiology, University of Adelaide, South Australia.
Leigh
C M
CM
Mirtschin
P J
PJ
D000997:Antivenins / Q000494:pharmacology*; D001514:Bee Venoms / Q000633:toxicity; D004907:Erythrocyte Deformability / Q000187:drug effects*; D005612:Freeze Drying; D006801:Humans; D066298:In Vitro Techniques; D008970:Molecular Weight; D008978:Mollusk Venoms / Q000633:toxicity; D012910:Snake Venoms / Q000276:immunology / Q000633:toxicity; D013111:Spider Venoms / Q000633:toxicity; D014688:Venoms / Q000633:toxicity*
D000997:Antivenins; D001514:Bee Venoms; D008978:Mollusk Venoms; D012910:Snake Venoms; D013111:Spider Venoms; D014688:Venoms