title: The long-term urological response of neonates with myelodysplasia treated proactively with intermittent catheterization and anticholinergic therapy.
abstract: OBJECTIVE
  Urinary tract management in children with myelodysplasia is controversial. Some advocate observation alone, while others believe that the prophylactic institution of intermittent catheterization and anticholinergic therapy may help to prevent deterioration.
  
  
  METHODS
  A nonrandomized prospective study was instituted to compare the urological outcomes of a cohort of children who were at risk for urological deterioration on the basis of bladder-sphincter dyssynergia and/or high filling or voiding pressures. Those at risk were observed until deterioration occurred, or were placed on prophylactic intermittent catheterization with or without anticholinergic medication.
  
  
  RESULTS
  Of 44 children at risk 35 followed by observation alone had urinary tract deterioration, whereas only 3 of 20 at risk treated with prophylactic intermittent catheterization had deterioration with time.
  
  
  CONCLUSIONS
  Proactive bladder treatment significantly reduced the incidence of upper urinary tract deterioration and need for surgical intervention.
authors.affiliation: Division of Urology, Children's Hospital, Boston, Massachusetts 02115, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Edelstein
authors.forename: S B
authors.initials: SB
authors.lastname: Bauer
authors.forename: M D
authors.initials: MD
authors.lastname: Kelly
authors.forename: M M
authors.initials: MM
authors.lastname: Darbey
authors.forename: C A
authors.initials: CA
authors.lastname: Peters
authors.forename: A
authors.initials: A
authors.lastname: Atala
authors.forename: J
authors.initials: J
authors.lastname: Mandell
authors.forename: A H
authors.initials: AH
authors.lastname: Colodny
authors.forename: A B
authors.initials: AB
authors.lastname: Retik
mesh_terms: D018680:Cholinergic Antagonists / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D006869:Hydronephrosis / Q000209:etiology / Q000517:prevention & control; D007231:Infant, Newborn; D008297:Male; D009436:Neural Tube Defects / Q000150:complications*; D011446:Prospective Studies; D012307:Risk Factors; D014546:Urinary Catheterization; D014570:Urologic Diseases / Q000209:etiology / Q000517:prevention & control*
chemical_list: D018680:Cholinergic Antagonists