Successful treatment of griseofulvin-resistant tinea capitis in infants.
We report on three siblings, children of a farmer, aged 3-8 years, suffering from tinea capitis due to Microsporum canis. Initially, the infection was treated systemically with griseofulvin as well as externally for 5 months without success. Therapy was changed to itraconazole 33 mg per day orally. Laboratory investigations followed every 4-6 weeks. Dependent on the dose per kg body weight the children were cured clinically after 2-5 months and microbiologically after 5-8 months. Thus, itraconazole seems to be superior to conventional treatment with Microsporum canis-induced tinea capitis.
Lukacs
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Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität München, Germany.
Korting
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HC
Lindner
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D002648:Child; D002675:Child, Preschool; D004352:Drug Resistance, Microbial; D005260:Female; D006118:Griseofulvin / Q000627:therapeutic use; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage / Q000627:therapeutic use; D008297:Male; D014006:Tinea Capitis / Q000188:drug therapy*
D017964:Itraconazole; D006118:Griseofulvin