Gynaecological complications of women treated with tamoxifen for breast cancer.
We present 6 cases illustrating some of the gynaecological complications associated with tamoxifen treatment of women with breast cancer. The first 2 represent cases of myometrial hypertrophy secondary to tamoxifen use, a postmenopausal woman and a premenopausal women with recurrent carcinoma of the breast. The third is a case of probable ovulation induction in a perimenopausal women with recurrent breast cancer who was commenced on tamoxifen 20 mg daily. The other 3 cases illustrate some of the endometrial effects associated with tamoxifen therapy in women with a history of breast cancer, namely cystic glandular hyperplasia, endometrial polyps and endometrial cancer.
Dew
J E
JE
Reproductive Endocrine and Infertility Unit, Royal Hospital for Women, Paddington, New South Wales.
Eden
J A
JA
D000230:Adenocarcinoma / Q000139:chemically induced; D000328:Adult; D001943:Breast Neoplasms / Q000188:drug therapy*; D004714:Endometrial Hyperplasia / Q000139:chemically induced; D016889:Endometrial Neoplasms / Q000139:chemically induced; D005260:Female; D006801:Humans; D007889:Leiomyoma / Q000139:chemically induced; D008875:Middle Aged; D010062:Ovulation Induction; D011127:Polyps / Q000139:chemically induced; D013629:Tamoxifen / Q000009:adverse effects* / Q000627:therapeutic use
D013629:Tamoxifen