Successful pregnancy after allogeneic bone marrow transplantation following conditioning with total body irradiation.
A 23-year-old woman had a normal full-term delivery 78 months after BMT for ALL. Conditioning therapy was Ara C 1.4 g/m2 x 4, CY 60 mg/kg x 2 and TBI 2.5 Gy x 5 at a dose rate of 3.5 cGy/min. Despite GVHD prophylaxis with short-term MTX and CsA, she developed grade I acute GVHD, but showed no evidence of chronic GVHD. Following amenorrhea for 4 years, menstruation recommenced spontaneously. She had a normal pregnancy 6 years after BMT resulting in a healthy infant with simple hypospadias. This and previous reports indicate that normal pregnancy is possible after BMT with TBI in excess of 10 Gy.
Maruta
A
A
Department of Haematology/Chemotherapy, Kanagawa Cancer Center, Yokohama, Japan.
Matsuzaki
M
M
Miyashita
H
H
Kodama
F
F
Kato
H
H
Taguchi
J
J
Tomita
N
N
Sakai
R
R
Fujisawa
S
S
Okubo
T
T
D000208:Acute Disease; D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D011247:Pregnancy; D011829:Radiation Dosage; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation