title: [Contrast-enhanced color-coded duplex ultrasound of high grade carotid stenoses].
abstract: OBJECTIVE
  The usefulness of SH-U-508A (Laevovist) in the quantification of high-grade internal carotid stenosis (ICA) is assessed in this study. 32 patients with high-grade ICA stenosis (> = 70%) or occlusion are examined using colour Doppler-assisted duplex imaging (CDDI) before and after injection of SH-U-508A.
  
  
  RESULTS
  The SH-U-508A-induced increase in blood echogenicity started at 9.8 s (mean; SD: 2.2) after bolus injection and peaked at 21 dB (mean; SD: 1.9; n = 12) after 14.8 s (mean; SD: 2.9). In addition, SH-U-508A led to a significant increase in systolic peak velocity determined in the common carotid artery, by 26% (mean; SD: 9; p < 0.05). Significant differences between non-enhanced and enhanced CDDI were found for the visualisation of the entire length of the intrastenotic residual lumen (43% vs 83%; p < 0.01). Correlations between non-enhanced and enhanced CDDI were high (r > 0.9) for the determination of cross-sectional area reduction and plaque length.
  
  
  CONCLUSIONS
  SH-U-508A may be useful in quantifying high-grade ICA stenoses with insufficient delineation at non-enhanced CDDI.
authors.affiliation: Institut für Diagnostische Radiologie Heinrich-Heine-Universität, Düsseldorf.
authors.forename: G
authors.initials: G
authors.lastname: Fürst
authors.forename: M
authors.initials: M
authors.lastname: Sitzer
authors.forename: M
authors.initials: M
authors.lastname: Hofer
authors.forename: H
authors.initials: H
authors.lastname: Steinmetz
authors.forename: T
authors.initials: T
authors.lastname: Hackländer
authors.forename: U
authors.initials: U
authors.lastname: Mödder
mesh_terms: D000368:Aged; D001783:Blood Flow Velocity / Q000502:physiology; D002343:Carotid Artery, Internal / Q000000981:diagnostic imaging; D016893:Carotid Stenosis / Q000000981:diagnostic imaging*; D003287:Contrast Media; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011134:Polysaccharides; D018615:Ultrasonography, Doppler, Color
chemical_list: D003287:Contrast Media; D011134:Polysaccharides; C059891:SHU 508
vernacular_title: Kontrastmittelverstärkte farbkodierte Duplexsonographie hochgradiger Karotisstenosen.