title: Computer analysis of transrectal ultrasound images of the prostate for the detection of carcinoma: a prospective study in radical prostatectomy specimens.
abstract: OBJECTIVE
  The reliability and objectivity of computer assisted transrectal ultrasound are examined.
  
  
  METHODS
  Pathological examination of radical prostatectomy specimens was compared prospectively to automated cancer detection in corresponding transrectal ultrasound images.
  
  
  RESULTS
  For automated cancer detection, a sensitivity of 0.75 and a specificity of 0.78 were obtained. Moreover, 74% of human interpretation of the percentage of malignancy in the analyzed images was equal to the actual calculated percentage (Pearson's product moment correlation coefficient 0.85).
  
  
  CONCLUSIONS
  Comparing these results to those obtained with normal transrectal ultrasound, automated analysis provides additional information in the interpretation of transrectal ultrasound images by color coding them in an objective manner according to the probability of malignancy.
authors.affiliation: Department of Urology, University Hospital Nijmegen, The Netherlands.
authors.forename: R J
authors.initials: RJ
authors.lastname: Giesen
authors.forename: A L
authors.initials: AL
authors.lastname: Huynen
authors.forename: R G
authors.initials: RG
authors.lastname: Aarnink
authors.forename: J J
authors.initials: JJ
authors.lastname: de la Rosette
authors.forename: C
authors.initials: C
authors.lastname: vd Kaa
authors.forename: G O
authors.initials: GO
authors.lastname: Oosterhof
authors.forename: F M
authors.initials: FM
authors.lastname: Debruyne
authors.forename: H
authors.initials: H
authors.lastname: Wijkstra
mesh_terms: D000368:Aged; D003936:Diagnosis, Computer-Assisted; D005188:False Negative Reactions; D005189:False Positive Reactions; D006801:Humans; D008297:Male; D008875:Middle Aged; D015588:Observer Variation; D011446:Prospective Studies; D011468:Prostatectomy; D011471:Prostatic Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology / Q000601:surgery; D015203:Reproducibility of Results; D012680:Sensitivity and Specificity; D014463:Ultrasonography