The quarantine of fertilized donated oocytes.
The fertilization and subsequent cryopreservation of donated oocytes have enabled the resulting embryos to be quarantined for a minimum of 6 months, and to be thawed and replaced only after the donor has had a second negative human immunodeficiency virus (HIV) test. In the study described here, a total of 39 women had 56 embryo transfers, and 12 pregnancies (21% per transfer) were achieved. The logic of the protocol for minimizing the risk of infection of the recipient, which is in line with that of semen donation, is presented, together with an argument for the feasibility of such an approach.
Hamer
F C
FC
Regional IVF Unit, St Mary's Hospital, Manchester, UK.
Horne
G
G
Pease
E H
EH
Matson
P L
PL
Lieberman
B A
BA
D000328:Adult; D001755:Blastocyst; D015925:Cryopreservation; D004624:Embryo Transfer; D005260:Female; D005307:Fertilization in Vitro; D015658:HIV Infections / Q000517:prevention & control / Q000635:transmission; D006801:Humans; D018587:Oocyte Donation; D011247:Pregnancy; D011790:Quarantine; D013997:Time Factors; D014019:Tissue Donors