title: Substitution cystoplasty for intractable interstitial cystitis.
abstract: OBJECTIVE
  To assess the results of substitution cystoplasty for the treatment of intractable interstitial cystitis (IC).
  
  
  METHODS
  Thirty-two patients (29 women and three men; mean age 58 years, range 24-74) with intractable IC resistant to conservative therapy who had undergone substitution cystoplasty between 1983 and 1992 were reviewed. Their bladder capacities were measured pre-operatively and related to the outcome of treatment.
  
  
  RESULTS
  All but two of the 22 women with a bladder capacity of < 250 mL under anaesthetic were improved (five) or cured (15) of their symptoms. The results in women with larger bladder capacities were much less reliable, with only two of seven being cured of their symptoms. The three men all had a good result. Those who had undergone supratrigonal cystectomy were more likely to void spontaneously, but four patients developed pyelonephritis from associated reflux. Subtotal cystectomy reduced the likelihood of reflux and, although there were too few patients for statistical significance, probably increased the chance of cure at the expense of increasing the need for intermittent self-catheterization (ISC).
  
  
  CONCLUSIONS
  Pre-operative bladder capacity under anaesthetic is the most reliable predictor of outcome of substitution cystoplasty for treating intractable IC in women. It is contra-indicated if bladder capacity is > 250 mL. Supratrigonal cystectomy is a quick and easy operation and is preferable in the older patient. Subtotal cystectomy with reimplantation of the ureters is preferable in the younger patient, even though it may increase the need for ISC.
authors.affiliation: Department of Urology, Cardiff Royal Infirmary, UK.
authors.forename: O D
authors.initials: OD
authors.lastname: Hughes
authors.forename: H G
authors.initials: HG
authors.lastname: Kynaston
authors.forename: B J
authors.initials: BJ
authors.lastname: Jenkins
authors.forename: T P
authors.initials: TP
authors.lastname: Stephenson
authors.forename: K C
authors.initials: KC
authors.lastname: Vaughton
mesh_terms: D000328:Adult; D000368:Aged; D003556:Cystitis / Q000503:physiopathology / Q000601:surgery*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D016896:Treatment Outcome; D001743:Urinary Bladder / Q000503:physiopathology / Q000601:surgery*