title: Effectiveness of a somatostatin analogue in lowering luteinizing hormone and insulin-stimulated secretion in hyperinsulinemic women with polycystic ovary disease.
abstract: OBJECTIVE
  To analyze the action of a long-acting somatostatin analogue on circulating insulin levels and on pituitary sensitivity to GnRH in women affected by polycystic ovary disease (PCOD).
  
  
  METHODS
  Controlled clinical study.
  
  
  METHODS
  Normal human volunteers in the Department of Obstetrics and Gynecology, Universita' Cattolica del Sacro Cuore.
  
  
  METHODS
  Twenty euglycemic women affected by PCOD, aged 19 to 30 years, were studied in their early follicular phase.
  
  
  METHODS
  A long-acting somatostatin analogue (octreotide) was administered SC for 6 weeks; an oral glucose tolerance test (OGTT), a GnRH test, and plasma hormone determinations were performed at baseline and repeated after 6 weeks of treatment. A glucose load also was performed after 1 week of treatment.
  
  
  METHODS
  Insulin and glucose serum concentrations were measured in all samples under the oral glucose stimulus, LH and FSH were measured under GnRH test. Plasma levels of PRL, sex hormone-binding globulin, androstenedione (A), T, 17 beta-hydroxyprogesterone, DHEAS, and cortisol were measured. Steroids also were assayed after the octreotide administration.
  
  
  RESULTS
  Based on the insulin response to OGTT, subjects were classified as hyperinsulinemic (n = 12) and normoinsulinemic (n = 8). Octreotide administration did not affect the glycemic levels in both groups. Octreotide significantly reduced insulin and LH exaggerated response to GnRH stimulus, as well as the A and T circulating levels, only in the hyperinsulinemic group.
  
  
  CONCLUSIONS
  A functional linkage exists between exaggerated insulin and LH-stimulated secretion in a group of polycystic ovary patients. Octreotide may be useful in normalizing these alterations and in reducing ovarian androgen secretion of hyperinsulinemic subjects.
authors.affiliation: Universita' Cattolica del Sacro Cuore, Rome, Italy.
authors.forename: A M
authors.initials: AM
authors.lastname: Fulghesu
authors.forename: A
authors.initials: A
authors.lastname: Lanzone
authors.forename: C L
authors.initials: CL
authors.lastname: Andreani
authors.forename: E
authors.initials: E
authors.lastname: Pierro
authors.forename: A
authors.initials: A
authors.lastname: Caruso
authors.forename: S
authors.initials: S
authors.lastname: Mancuso
mesh_terms: D000328:Adult; D005260:Female; D007987:Gonadotropin-Releasing Hormone; D006801:Humans; D006946:Hyperinsulinism / Q000097:blood* / Q000150:complications; D007328:Insulin / Q000097:blood*; D007986:Luteinizing Hormone / Q000097:blood*; D015282:Octreotide / Q000627:therapeutic use*; D011085:Polycystic Ovary Syndrome / Q000097:blood* / Q000150:complications / Q000188:drug therapy; D012016:Reference Values; D013004:Somatostatin / Q000031:analogs & derivatives*
chemical_list: D007328:Insulin; D007987:Gonadotropin-Releasing Hormone; D013004:Somatostatin; D007986:Luteinizing Hormone; D015282:Octreotide