[Changes in cytomembrane and surface cells of the large intestine resulting from the action of sweetening agents].
Saccharin and cyclamates have been proved to cause organic damage. This work attempt to describe drug-induced changes brought about by drugs in 1/1000 saccharin and cyclamate-fed rats for 90 days. The ultrastructural findings show: microvilli hypertrophy; membranous mitochondrial increase in absorptive cells; and secretion changes in calciform cells. Such changes are cell-response phenomena to interference or mutagenic action on nuclear DNA or on cytoplasmatic metabolism.
Torres de Mercau
G
G
Cátedra de Histología-Facultad de Medicina, Universidad Nacional de Tucumán.
Riera de Martínez Villa
N
N
Mercau
G A
GA
Martínez Riera
N
N
Soria de Santos
N
N
Vitalone
H
H
D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D003494:Cyclamates / Q000009:adverse effects* / Q000633:toxicity; D004032:Diet; D005260:Female; D007420:Intestine, Large / Q000187:drug effects* / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D012439:Saccharin / Q000009:adverse effects* / Q000633:toxicity
D003494:Cyclamates; D012439:Saccharin
Alteraciones en la citomembrana y células de superficie del intestino grueso por acción de los edulcorantes.