Sucrose polyester and plasma carotenoid concentrations in healthy subjects.
A double-blind, placebo-controlled crossover study of the effects of the nonabsorbable fat analogue sucrose polyester (SPE; 12.4 g/d) on plasma concentrations of five different carotenoids and vitamin E in 21 volunteers, and a double-blind, placebo-controlled parallel comparison study in 53 subjects of the effect of 3 g SPE/d on plasma concentrations of two different carotenoids were undertaken. SPE-containing margarine added to the main meal was used. SPE (12.4 g/d) reduced plasma of beta-carotene concentrations by 0.13 mumol/L (34%, P = 0.0001) and concentrations of lycopene by 0.14 mumol/L (52%, P = 0.0001). Smaller but significant reductions were found for plasma concentrations of beta-cryptoxanthin, lutein, zeaxanthin, and vitamin E. SPE (3 g/d) reduced plasma concentrations of beta-carotene by 0.094 mumol/L (20% P = 0.0001) and concentrations of lycopene by 0.12 mumol/L (38%, P = 0.0001). Even at low doses, SPE strongly reduces plasma carotenoid concentrations. This finding merits careful consideration in assessing the long-term health effects of SPE-containing consumer foods.
Weststrate
J A
JA
Unilever Research Laboratorium, Vlaardingen, Netherlands.
van het Hof
K H
KH
D000328:Adult; D002338:Carotenoids / Q000008:administration & dosage / Q000097:blood*; D018592:Cross-Over Studies; D004032:Diet; D004042:Dietary Fats, Unsaturated / Q000378:metabolism; D004311:Double-Blind Method; D005227:Fatty Acids / Q000378:metabolism*; D005260:Female; D006801:Humans; D008055:Lipids / Q000097:blood; D000077276:Lycopene; D008297:Male; D008875:Middle Aged; D009994:Osmolar Concentration; D012016:Reference Values; D013395:Sucrose / Q000031:analogs & derivatives* / Q000378:metabolism; D014810:Vitamin E / Q000008:administration & dosage / Q000097:blood; D019207:beta Carotene
D004042:Dietary Fats, Unsaturated; D005227:Fatty Acids; D008055:Lipids; D019207:beta Carotene; D014810:Vitamin E; D002338:Carotenoids; D013395:Sucrose; C013692:sucrose polyester; D000077276:Lycopene