BDNF attenuates the effects of intrastriatal injection of 6-hydroxydopamine.
Groups of eight rats received unilateral, intrastriatal injections of 22.5 micrograms brain-derived neurotrophic factor (BDNF) or cytochrome c on 3 consecutive days. Following the injection of BDNF or cytochrome c on the second day, each animal received an intrastriatal injection of 25 micrograms of 6-hydroxydopamine (6-OHDA). During the second week following treatment and thereafter, the animals that received BDNF had significantly fewer apomorphine-induced, contraversive rotations than did the animals that received cytochrome c. The animals that received BDNF but not those that received cytochrome c had a halo of dopaminergic axons around the injection site. Our data indicate that BDNF can attenuate the loss of dopaminergic axons and rotational asymmetry that result from an intrastriatal injection of 6-OHDA.
Shults
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Veterans Affairs Medical Center 127, San Diego, CA 92161, USA.
Kimber
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D000818:Animals; D001369:Axons / Q000187:drug effects; D001522:Behavior, Animal / Q000187:drug effects; D019208:Brain-Derived Neurotrophic Factor; D003342:Corpus Striatum / Q000187:drug effects*; D004357:Drug Synergism; D005260:Female; D009043:Motor Activity / Q000187:drug effects; D009419:Nerve Tissue Proteins / Q000494:pharmacology*; D016627:Oxidopamine / Q000494:pharmacology*; D016548:Prosencephalon / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley; D013997:Time Factors
D019208:Brain-Derived Neurotrophic Factor; D009419:Nerve Tissue Proteins; D016627:Oxidopamine