title: Non-steroidal anti-inflammatory drugs fail to enhance healing of acute hamstring injuries treated with physiotherapy.
abstract: The effects of two non-steroidal anti-inflammatory drugs (NSAIDs), meclofenamate and diclofenac, in combination with physiotherapy modalities on the rate of healing of acute hamstring muscle tears were studied in a double-blind, placebo-controlled trial. Fourty-four of the 75 patients with this injury recruited were assessed and randomly allocated to one of three treatment groups: meclofenamate (100 mg 3 times a day), diclofenac (50 mg 3 times a day) and placebo. All patients received the same intensive physiotherapy treatment over the 7-day treatment period. Patient assessments were performed on days 1, 3 and 7 of the 7-day study period and included pain assessment (visual analogue scale), swelling measurement (thigh circumference measurement at the site of the muscle tear) and isokinetic muscle performance testing. Treatment produced a significant improvement in all measurements in all groups, but there was no difference in any measurement between groups. However, when only the more severe injuries were analysed, the reported pain score at day 7 was significantly lower in the placebo group than in either the meclofenamate group or the diclofenac group (P < 0.05). Hence this study did not find any additive effect on the healing of acute muscle injuries when meclofenamate or diclofenac was added to standard physiotherapeutic modalities. The study therefore does not support the use of NSAIDs in the treatment of acute hamstring muscle injuries.
authors.affiliation: MRC/UCT Bioenergetics of Exercise Research Unit, University of Cape Town.
authors.forename: J F
authors.initials: JF
authors.lastname: Reynolds
authors.forename: T D
authors.initials: TD
authors.lastname: Noakes
authors.forename: M P
authors.initials: MP
authors.lastname: Schwellnus
authors.forename: A
authors.initials: A
authors.lastname: Windt
authors.forename: P
authors.initials: P
authors.lastname: Bowerbank
mesh_terms: D000328:Adult; D001265:Athletic Injuries / Q000188:drug therapy / Q000628:therapy*; D003131:Combined Modality Therapy; D004008:Diclofenac / Q000009:adverse effects / Q000627:therapeutic use*; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008469:Meclofenamic Acid / Q000009:adverse effects / Q000627:therapeutic use*; D018482:Muscle, Skeletal / Q000293:injuries*; D026741:Physical Therapy Modalities
chemical_list: D004008:Diclofenac; D008469:Meclofenamic Acid