title: Frequency of voice problems and cough in patients using pressurized aerosol inhaled steroid preparations.
abstract: The aim of the study was to assess the prevalence of throat and voice symptoms in asthma patients using pressurized aerosol, metered-dose, inhaled corticosteroid preparations. A questionnaire was administered to hospital out-patients in an asthma clinic and to a control group attending a diabetic clinic. Two hundred and fifty five consecutive out-patients using pressurized aerosol inhaled corticosteroids and 100 controls were surveyed. One hundred and forty seven (58%) patients taking inhaled steroids reported voice dysphonia or throat symptoms compared with 13% of control patients. Women admitted to symptoms more frequently than men. Throat symptoms were more prevalent in patients using higher doses of inhaled steroid. Aerosol inhaler-induced cough was reported by 87 (34%) patients. Local side-effects were equally prevalent both with beclomethasone dipropionate and budesonide aerosol inhalers. The use of a large volume spacing device with either steroid aerosol did not appear to protect against these symptoms. Local side-effects are common in asthmatics taking pressurized aerosol, metered-dose, inhaled steroids.
authors.affiliation: Respiratory Unit, Western General Hospital, Edinburgh, Scotland.
authors.forename: I J
authors.initials: IJ
authors.lastname: Williamson
authors.forename: S P
authors.initials: SP
authors.lastname: Matusiewicz
authors.forename: P H
authors.initials: PH
authors.lastname: Brown
authors.forename: A P
authors.initials: AP
authors.lastname: Greening
authors.forename: G K
authors.initials: GK
authors.lastname: Crompton
mesh_terms: D000336:Aerosols; D000893:Anti-Inflammatory Agents / Q000008:administration & dosage / Q000009:adverse effects*; D001249:Asthma / Q000188:drug therapy*; D001507:Beclomethasone / Q000008:administration & dosage / Q000009:adverse effects*; D019819:Budesonide; D016022:Case-Control Studies; D003371:Cough / Q000139:chemically induced* / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009330:Nebulizers and Vaporizers; D010044:Outpatient Clinics, Hospital; D011282:Pregnenediones / Q000008:administration & dosage / Q000009:adverse effects*; D015995:Prevalence; D011795:Surveys and Questionnaires; D014832:Voice Disorders / Q000139:chemically induced* / Q000453:epidemiology
chemical_list: D000336:Aerosols; D000893:Anti-Inflammatory Agents; D011282:Pregnenediones; D019819:Budesonide; D001507:Beclomethasone