Abnormalities of skeletal muscle metabolism during nerve stimulation determined by 31P nuclear magnetic resonance spectroscopy in severe congestive heart failure.
These data confirm the presence of abnormal skeletal muscle metabolic function in patients with chronic heart failure. These changes are independent of patient compliance and central hemodynamic response to conventional exercise, and may explain, in part, the marked decrease in exercise tolerance often observed in patients with chronic severe heart failure. The etiology of these abnormalities of metabolic function and nutritive flow remains uncertain. TNS may prove useful in further elucidation of the peripheral metabolic consequences of chronic heart failure.
Kao
W
W
Henry Ford Heart and Vascular Institute, Department of Neurology, Henry Ford Hospital, Detroit, Michigan, USA.
Helpern
J A
JA
Goldstein
S
S
Gheorghiade
M
M
Levine
B
B
D000208:Acute Disease; D000328:Adult; D000368:Aged; D005260:Female; D006333:Heart Failure / Q000378:metabolism* / Q000628:therapy; D006801:Humans; D006863:Hydrogen-Ion Concentration; D009682:Magnetic Resonance Spectroscopy / Q000295:instrumentation / Q000379:methods; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000378:metabolism*; D004561:Transcutaneous Electric Nerve Stimulation / Q000379:methods