[The action of the alkanol ammonium salts of aroxyacetic acids on the thrombocyte aggregation process].
Tris(2-hydroxyethyl)ammoniates of ezo-substituted aroxyalkane-carboxylic acids were examined for their effects on in vitro platelet aggregation under the influence of biogenic amines, as well as in lipid peroxidation. Hemocoagulation was evaluated in vivo. The agents tested were demonstrated no be a promising class of platelet aggregation inhibitors. They possess antioxidative effects, by reducing the level of malonic dialdehyde in induced hyperaggregation and the rate of lipid peroxidation. When given to animals, the agents decreased the activity of prothrombin factors.
Kazimirovskaia
V B
VB
Semenova
N V
NV
Moskvitina
L T
LT
Nepsha
V D
VD
Novikova
N V
NV
Voronkov
M G
MG
D000085:Acetates / Q000494:pharmacology*; D000244:Adenosine Diphosphate / Q000494:pharmacology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology*; D015227:Lipid Peroxidation / Q000187:drug effects; D008163:Luminescent Measurements; D008315:Malondialdehyde / Q000097:blood; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000494:pharmacology*; D011817:Rabbits; D013329:Structure-Activity Relationship; D013997:Time Factors
D000085:Acetates; D000975:Antioxidants; D010975:Platelet Aggregation Inhibitors; D008315:Malondialdehyde; D000244:Adenosine Diphosphate
Deĭstvie alkanolammonievykh soleĭ aroksiuksusnykh kislot na protsess agregatsii trombotsitov.