title: Macular microcirculation in cystoid maculopathy of diabetic patients.
abstract: BACKGROUND
  In patients with diabetic macular oedema and central cysts ischaemia of the retina appears to be an important contributing factor in the pathogenesis of cysts. This study was performed to further elucidate the role of the inner retinal microcirculation in diabetic cystoid macular oedema (CMO).
  
  
  METHODS
  Video fluorescein angiography allows visualisation of the macular microvasculature and measurements of the capillary blood velocity (CBV), foveal avascular zone (FAZ), and perifoveal intercapillary area (PIA, characterising capillary density).
  
  
  RESULTS
  Twenty three diabetic subjects with CMO, matched diabetic patients without macular oedema (n = 23), and healthy subjects (n = 23) were included. CBV, PIA, and FAZ did not differ significantly among diabetic groups regardless of presence of cystoid changes. CBV was significantly reduced (p < 0.0001) and PIA was more than doubled in both diabetic groups (p < 0.0001) when compared with healthy subjects. Furthermore, FAZ showed a nearly doubled size in diabetic patients without macular oedema (p < 0.01) and a less pronounced enlargement (by 29%) in diabetics with CMO (p < 0.05).
  
  
  CONCLUSIONS
  The results indicate that the retinal microcirculation in diabetic patients is markedly altered when compared with healthy subjects, regardless of CMO presence. In CMO patients the microcirculatory changes are similar to those of diabetic patients without macular oedema. Thus inner retinal perfusion does not contribute to tissue ischaemia leading to cystoid formations in diabetic maculopathy.
authors.affiliation: Augenklinik der Med Fak der RWTH, Aachen, Germany.
authors.forename: O
authors.initials: O
authors.lastname: Arend
authors.forename: A
authors.initials: A
authors.lastname: Remky
authors.forename: A
authors.initials: A
authors.lastname: Harris
authors.forename: B
authors.initials: B
authors.lastname: Bertram
authors.forename: M
authors.initials: M
authors.lastname: Reim
authors.forename: S
authors.initials: S
authors.lastname: Wolf
mesh_terms: D000328:Adult; D000368:Aged; D001783:Blood Flow Velocity; D003930:Diabetic Retinopathy / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D005260:Female; D005451:Fluorescein Angiography; D005584:Fovea Centralis / Q000098:blood supply; D006801:Humans; D007511:Ischemia / Q000150:complications; D007834:Lasers; D008266:Macula Lutea / Q000098:blood supply*; D008269:Macular Edema / Q000209:etiology / Q000473:pathology* / Q000503:physiopathology; D008297:Male; D008833:Microcirculation / Q000473:pathology; D008875:Middle Aged; D009887:Ophthalmoscopy / Q000379:methods