Transforming growth factor-alpha expression in in situ epidermal neoplasia.
Twenty cases of solar keratosis and 15 cases of Bowen's disease were investigated for the expression of transforming growth factor alpha (TGF-alpha) by an indirect immunoperoxidase technique using monoclonal antibody TGF-alpha AB-2 in formalin-fixed wax-embedded tissue. Twelve cases (60%) of solar keratosis and 13 cases (86%) of Bowen's disease showed marked overexpression of TGF-alpha in both membranous and cytoplasmic distributions. This suggests that overexpression of TGF-alpha may play an important role in the evolution of these two neoplastic conditions.
Grant
J J
JJ
Army Histology Registry, Royal Army Medical College, Millbank, London, UK.
Howes
G
G
McKee
P H
PH
D001913:Bowen's Disease / Q000737:chemistry*; D002462:Cell Membrane / Q000737:chemistry; D003593:Cytoplasm / Q000737:chemistry; D006801:Humans; D007124:Immunoenzyme Techniques; D007642:Keratosis; D012878:Skin Neoplasms / Q000737:chemistry*; D016211:Transforming Growth Factor alpha / Q000032:analysis*
D016211:Transforming Growth Factor alpha