A PC-based graphical simulator for physiological pharmacokinetic models.
Since many intravenous anesthetic drugs alter blood flows, physiologically-based pharmacokinetic models describing drug disposition may be time-varying. Using the commercially available programming software MATLAB, a platform to simulate time-varying physiological pharmacokinetic models was developed. The platform is based upon a library of pharmacokinetic blocks which mimic physiological structure. The blocks can be linked together flexibly to form models for different drugs. Because of MATLAB's additional numerical capabilities (e.g. non-linear optimization), the platform provides a complete graphical microcomputer-based tool for physiologic pharmacokinetic modeling.
Wada
D R
DR
Stanford University, Department of Anesthesia, CA 94305-5117, USA.
Stanski
D R
DR
Ebling
W F
WF
D000777:Anesthetics / Q000493:pharmacokinetics; D000818:Animals; D003196:Computer Graphics; D003198:Computer Simulation; D006801:Humans; D008838:Microcomputers; D008954:Models, Biological; D010599:Pharmacokinetics; D010827:Physiology; D012984:Software; D014018:Tissue Distribution
D000777:Anesthetics