The Drosophila learning and memory gene linotte encodes a putative receptor tyrosine kinase homologous to the human RYK gene product.
The linotte mutant was isolated on the basis of its learning and memory deficit. Interestingly, linotte individuals carrying a null mutation are viable, indicating that the linotte gene is not required for vital functions. We show here that the linotte gene encodes a putative receptor tyrosine kinase, homologous to the human protein RYK. These products are unique among receptor tyrosine kinases, since they possess a short extra cellular domain, and a modified intracellular catalytic domain. In particular, the subdomains directly involved in ATP binding and phosphotransfer reaction display remarkable variations. These results suggest that linotte is part of a novel signal transduction cascade involved in learning and memory.
Dura
J M
JM
C.N.R.S., U.R.A. D 1134, Laboratoire d'Embryologie Moléculaire, Université Paris XI, Orsay, France.
Taillebourg
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Préat
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D000595:Amino Acid Sequence; D000818:Animals; D001665:Binding Sites; D004251:DNA Transposable Elements; D018076:DNA, Complementary; D004330:Drosophila / Q000235:genetics*; D017344:Genes, Insect; D006801:Humans; D007438:Introns; D007858:Learning / Q000502:physiology*; D008568:Memory / Q000502:physiology; D008969:Molecular Sequence Data; D009154:Mutation; D020794:Receptor Protein-Tyrosine Kinases / Q000737:chemistry* / Q000235:genetics* / Q000378:metabolism; D011956:Receptors, Cell Surface / Q000737:chemistry*; D017386:Sequence Homology, Amino Acid
D004251:DNA Transposable Elements; D018076:DNA, Complementary; D011956:Receptors, Cell Surface; C080836:RYK protein, human; D020794:Receptor Protein-Tyrosine Kinases