title: Immunoscintigraphy using 111in-labelled F(ab')2 fragments of anti-carcinoembryonic antigen (CEA) monoclonal antibody for staging of non-small cell lung carcinoma.
abstract: 28 patients with primitive lung cancers were imaged by immunoscintigraphy (IS) with 111indium-labelled F(ab')2 anti-carcinoembryonic antigen (CEA), to assess this technique for mediastinal staging. IS revealed primitive tumours in 21 cases in whom mediastinal extension was assessed. There was concordance between clinical staging and IS confirmed by surgery in 17 cases, and discordance in 4. After surgery, discordance was in favour of IS in 2 cases (1 true positive and 1 true negative) and in favour of clinical staging in 2 (false positive of immunoscintigraphy). Anti-CEA IS could be useful for improving mediastinal staging of lung cancer.
authors.affiliation: Department of Nuclear Medicine and Biophysics, L.E.R., URA CNRS 1287, U.F.R. de Médecine, La Tronche, France.
authors.forename: J P
authors.initials: JP
authors.lastname: Vuillez
authors.forename: D
authors.initials: D
authors.lastname: Moro
authors.forename: E
authors.initials: E
authors.lastname: Brambilla
authors.forename: P Y
authors.initials: PY
authors.lastname: Brichon
authors.forename: G
authors.initials: G
authors.lastname: Ferretti
authors.forename: J C
authors.initials: JC
authors.lastname: Saccavini
authors.forename: C
authors.initials: C
authors.lastname: Brambilla
mesh_terms: D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen / Q000276:immunology*; D002289:Carcinoma, Non-Small-Cell Lung / Q000000981:diagnostic imaging* / Q000473:pathology; D006801:Humans; D007140:Immunoglobulin Fab Fragments; D007205:Indium Radioisotopes; D008175:Lung Neoplasms / Q000000981:diagnostic imaging* / Q000473:pathology; D009367:Neoplasm Staging; D016719:Radioimmunodetection
chemical_list: D000911:Antibodies, Monoclonal; D002272:Carcinoembryonic Antigen; D007140:Immunoglobulin Fab Fragments; D007205:Indium Radioisotopes