[The local anesthetic activity of inclusion compounds of pirbentan and trimecaine with beta-cyclodextrin].
Whether the prolonged action of the topical anesthetics trimecaine and pirbentan can be achieved by using inclusion compounds was studied. beta-Cyclodextrin was used as an agent containing topical anesthetics in its molecule. In in vitro and in vivo experiments, the inclusion compounds trimecaine and pirbentan with beta-cyclodextrin produced a more prolonged action in terminal anesthesia than the compounds used alone.
Kuiantseva
A M
AM
Kompantseva
E V
EV
Lukashova
L A
LA
Zakrzhevskaia
T N
TN
D000779:Anesthetics, Local / Q000493:pharmacokinetics / Q000494:pharmacology*; D000818:Animals; D001702:Biopharmaceutics; D003505:Cyclodextrins / Q000493:pharmacokinetics / Q000494:pharmacology*; D003692:Delayed-Action Preparations; D003956:Dialysis; D004338:Drug Combinations; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008567:Membranes, Artificial; D014288:Trimecaine / Q000493:pharmacokinetics / Q000494:pharmacology*; D047392:beta-Cyclodextrins
D000779:Anesthetics, Local; D003505:Cyclodextrins; D003692:Delayed-Action Preparations; D004338:Drug Combinations; D008567:Membranes, Artificial; D047392:beta-Cyclodextrins; D014288:Trimecaine; C031215:betadex
Issledovanie mestnoanesteziruiushcheĭ aktivnosti soedineniĭ vkliucheniia porbentana i trimekaina s beta-tsiklodekstrinom.