title: Circulating interleukin-6 receptor in patients with sepsis syndrome.
abstract: Concentrations of interleukin (IL)-6, soluble IL-6 receptor (sIL-6R), and soluble tumor necrosis factor receptor (sTNFR) p55 and p75 were measured in 25 patients with sepsis syndrome. Sequential blood samples were drawn from patients during a 7-h period. IL-6 concentrations were 34-763,000 pg/mL; they were higher in nonsurvivors than survivors, but the difference was not statistically significant. In septic patients, the median sIL-6R concentration was significantly lower than in 19 healthy volunteers (43 vs. 80 ng/mL). sIL-6R concentrations in survivors were not significantly different than those in nonsurvivors. There was a negative correlation between IL-6 and sIL-6R in septic patients (r = -.72). In patients with moderately impaired renal function, sIL-6R levels were not affected, but the concentrations of sTNFRs were significantly higher.
authors.affiliation: Department of Surgery, University Hospital Nijmegen, Netherlands.
authors.forename: J T
authors.initials: JT
authors.lastname: Frieling
authors.forename: M
authors.initials: M
authors.lastname: van Deuren
authors.forename: J
authors.initials: J
authors.lastname: Wijdenes
authors.forename: J W
authors.initials: JW
authors.lastname: van der Meer
authors.forename: C
authors.initials: C
authors.lastname: Clement
authors.forename: C J
authors.initials: CJ
authors.lastname: van der Linden
authors.forename: R W
authors.initials: RW
authors.lastname: Sauerwein
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015703:Antigens, CD; D005260:Female; D006801:Humans; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D018123:Receptors, Interleukin / Q000032:analysis*; D019947:Receptors, Interleukin-6; D018124:Receptors, Tumor Necrosis Factor / Q000032:analysis*; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II; D018746:Systemic Inflammatory Response Syndrome / Q000097:blood*
chemical_list: D015703:Antigens, CD; D015850:Interleukin-6; D018123:Receptors, Interleukin; D019947:Receptors, Interleukin-6; D018124:Receptors, Tumor Necrosis Factor; D047888:Receptors, Tumor Necrosis Factor, Type I; D047889:Receptors, Tumor Necrosis Factor, Type II