Current state of purinoceptor research.
It is hoped that this summary of the history and current status of purinoceptors will convince readers that receptors for purines are now established alongside other well-known extracellular messenger systems. These receptors are primitive, widespread and serve many different systems. Receptors of adenosine (P1-purinoceptors) are clearly different from receptors of ATP (P2-purinoceptors). As for other major transmitters such as acetylcholine, GABA, glutamate and 5-HT, receptors of two major families are activated by ATP, one (the P2X-purinoceptor family) mediates fast responses via ligand-gated ion channels, while the other (the P2Y-purinoceptor family) mediates slower responses via G-proteins (see Table 3). Subclasses of these two families have been suggested on the basis of recent molecular biology studies and the development of new selective agonists and antagonists (Abbracchio and Burnstock, 1994). It would indeed be helpful if the work on purinoceptors could be extended to studies of their chemical structure employing crystallography.
Burnstock
G
G
Department of Anatomy and Developmental Biology, University College London, UK.
D000818:Animals; D006801:Humans; D011983:Receptors, Purinergic / Q000187:drug effects / Q000502:physiology*; D018047:Receptors, Purinergic P1 / Q000187:drug effects / Q000502:physiology; D018048:Receptors, Purinergic P2 / Q000187:drug effects / Q000502:physiology
D011983:Receptors, Purinergic; D018047:Receptors, Purinergic P1; D018048:Receptors, Purinergic P2