Dynamic exercise induces elevation of plasma levels of endothelin-1 in patients with coronary artery disease.
In this investigation the response of endothelin-1 plasma levels to dynamic exercise in patients with coronary artery disease (CAD) was studied. The study population consisted of 20 patients with CAD, 16 men and 4 women (mean age 53 +/- 8.6 years). Seven normal volunteers all men (mean age 53.4 +/- 4.4 years) were studied as a control group. Seven patients had prior myocardial infarction. All patients and controls exercised on a multi-stage bicycle ergometer; plasma endothelin-1 levels and hemodynamic indices were measured at rest, at peak exercise, and at two and six minutes after exercise. Of the 20 patients examined, 7 (35%) showed electrocardiogrpahic (ECG) signs of myocardial ischemia during the stress test. The mean plasma endothelin-1 concentration increased significantly from 7.8 +/- 3.0 to 13.6 +/- 3.5 pg/mL at exercise peak (P < 0.05) only in patients who did not show ECG signs of myocardial ischemia and returned to baseline values during recovery (six minutes) (9.4 +/- 2.1 pg/mL). In normal subjects baseline endothelin-1 levels (9.4 +/- 4.2 pg/mL) were not significantly altered at peak exercise (10.8 +/- 4.7 pg/mL) and at recovery (11.3 +/- 3.6 pg/mL). The hemodynamic parameters were not correlated with the plasma endothelin-1 levels before, during, and after exercise in all groups. The present study demonstrated that the plasma levels of endothelin-1 in patients with CAD increased significantly during stress testing.
Letizia
C
C
Medical Pathology I, University of Rome La Sapienza, Italy.
Barillà
F
F
Cerci
S
S
D'Ambrosio
C
C
Coassin
S
S
De Ciocchis
A
A
Mastroianni
M A
MA
Campa
P P
PP
Scavo
D
D
D000328:Adult; D000368:Aged; D000704:Analysis of Variance; D003327:Coronary Disease / Q000097:blood* / Q000503:physiopathology; D016232:Endothelins / Q000097:blood*; D015444:Exercise / Q000502:physiology*; D005080:Exercise Test / Q000706:statistics & numerical data; D005260:Female; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D011863:Radioimmunoassay
D016232:Endothelins