[Idiopathic Parkinson disease and mitochondrial functions].
Work on the molecular mechanisms of MPTP neurotoxicity have inspired search into the function of mitochondria in idiopathic Parkinson's disease. All the studies show a decrease of 30 to 40% in the activity of the respiratory complex I in the mitochondria of the nigra substantia. This decreased activity is not found in other degenerative Parkinsonisms treated with L-Dopa and cannot be explained simply by age. It is not found in other tissues including muscles and platelets. The causal mechanism of this mitochondrial dysfunction is unknown but it is not related to a mutation in mitochondrial DNA.
Tranchant
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C
Service des Maladies du Système Nerveux et du Muscle, CHU, Strasbourg.
Weess
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C
Warter
J M
JM
D006801:Humans; D008928:Mitochondria / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*; D010084:Oxidation-Reduction; D010300:Parkinson Disease / Q000503:physiopathology*; D013378:Substantia Nigra / Q000201:enzymology / Q000378:metabolism / Q000502:physiology*
Maladie de Parkinson idiopathique et fonctions mitochondriales.