Molecular breakpoints of t(11;14)(q13;q32) in multiple myeloma.
We found a t(11;14)(q13;q32) translocation in six patients with multiple myeloma (MM) or plasma cell leukemia. In five of them, rearrangements of BCL1 and PRAD1 could be studied. Two patients showed a rearrangement only with the Prad1 probe, located 120 kb telomeric of the major translocation cluster. The three other patients lacked rearrangements with both Bcl1 and Prad1.
Meeus
P
P
Center for Human Genetics, University of Leuven, Belgium.
Stul
M S
MS
Mecucci
C
C
Cassiman
J J
JJ
Van den Berghe
H
H
D002880:Chromosomes, Human, Pair 11; D002883:Chromosomes, Human, Pair 14; D006801:Humans; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D009101:Multiple Myeloma / Q000235:genetics*; D014178:Translocation, Genetic