[Effects of m-nifedipine on left ventricular diastolic function and Ca2+ content of myocardial and cerebral mitochondria and artery tissues in left ventricular hypertrophied rats].
Left ventricular hypertrophy (LVH) was induced by renal hypertension in rats. m-Nifedipine (m-Nif, ig 20 mg.kg-1.d-1 for 9 wk) decreased LV weight in the renovascular hypertensive rats (P < 0.01). The LV compliance in LVH group was significantly decreased compared with that in sham- operated group. The LV stiffness constant, Ca2+ content in left ventricular myocardial and cerebral mitochondria, aorta, and tail artery were markedly raised. m-Nif could markedly reduce the LV stiffness constant, improve the LV compliance, and decrease the Ca2+ content of left ventricular myocardial mitochondria and tissues of artery from LVH rats. These effects of m-Nif were similar to those of nifedipine at the same dosage.
Xi
T
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Department of Cardiovascular Pharmacology, Nanjing Medical University.
Rao
M R
MR
D000818:Animals; D001011:Aorta / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D003971:Diastole / Q000187:drug effects; D006978:Hypertension, Renovascular / Q000150:complications; D017379:Hypertrophy, Left Ventricular / Q000503:physiopathology*; D007536:Isomerism; D008297:Male; D008928:Mitochondria / Q000378:metabolism; D008929:Mitochondria, Heart / Q000378:metabolism*; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D016277:Ventricular Function, Left / Q000187:drug effects*
D009543:Nifedipine; D002118:Calcium