Liposome-encapsulated muramyl tripeptide phosphatidylethanolamine for the treatment of feline mammary adenocarcinoma--a multicenter randomized double-blind study.
Forty cats with previously untreated, histologically confirmed mammary gland adenocarcinoma received a radical mastectomy of the affected mammary chain(s). All cats were stratified according to clinical stage and randomized to receive either weekly intravenous liposome-encapsulated muramyl tripeptide phosphatidylethanolamine or placebo (lipid-equivalent) for eight consecutive weeks in this double-blind study. Thirty-six of the 40 cats were available for follow-up. No significant differences in either disease-free interval or survival were found as a result of treatment. Cats with clinical stage II disease had a statistically significantly longer disease-free interval (p < 0.02), and overall survival (p < 0.005) when compared with clinical stage III cats.
Fox
L E
LE
University of Florida, College of Veterinary Medicine, Gainesville 32610-0126, USA.
MacEwen
E G
EG
Kurzman
I D
ID
Dubielzig
R R
RR
Helfand
S C
SC
Vail
D M
DM
Kisseberth
W
W
London
C
C
Madewell
B R
BR
Rodriguez
C O
CO
D000119:Acetylmuramyl-Alanyl-Isoglutamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000230:Adenocarcinoma / Q000188:drug therapy / Q000401:mortality / Q000601:surgery / Q000662:veterinary*; D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use*; D002371:Cat Diseases / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D002415:Cats; D017024:Chemotherapy, Adjuvant; D018572:Disease-Free Survival; D004311:Double-Blind Method; D005260:Female; D005500:Follow-Up Studies; D007262:Infusions, Intravenous; D008081:Liposomes; D008297:Male; D015674:Mammary Neoplasms, Animal / Q000188:drug therapy* / Q000401:mortality / Q000601:surgery; D015409:Mastectomy, Radical; D009367:Neoplasm Staging; D010714:Phosphatidylethanolamines / Q000627:therapeutic use*; D015996:Survival Rate
D000970:Antineoplastic Agents; D008081:Liposomes; D010714:Phosphatidylethanolamines; C037144:mifamurtide; D000119:Acetylmuramyl-Alanyl-Isoglutamine