title: [ECG-gated dual isotope myocardial SPECT with 99mTc-MIBI and 123I-BMIPP in patients with ischemic heart disease].
abstract: Simultaneous dual-isotope SPECT with 99mTc-methoxy isobutyl isonitrile (MIBI) and 123I-beta-methyl iodophenyl-pentadecanoic acid (BMIPP) was performed in 25 patients with ischemic heart disease. ECG-gated myocardial SPECT was acquired following the injection of MIBI (555 MBq) and BMIPP (148 MBq). Both MIBI and BMIPP scans provided high-quality myocardial images. Then, myocardial count increase rate (%WT = ES-ED/ED x 100) was calculated as an index of left ventricular contraction using MIBI gated SPECT data. The %WT was well correlated with severity scores of both MIBI image (r = -0.70) and BMIPP image (r = -0.72). Thus, ECG-gated dual-isotope SPECT with MIBI and BMIPP was considered to be useful method for assessment of left ventricular contraction as well as myocardial perfusion and fatty acid metabolism.
authors.affiliation: Department of Radiology, Nippon Medical School, Tokyo.
authors.forename: S
authors.initials: S
authors.lastname: Kumita
authors.forename: S
authors.initials: S
authors.lastname: Mizumura
authors.forename: T
authors.initials: T
authors.lastname: Kijima
authors.forename: M
authors.initials: M
authors.lastname: Machida
authors.forename: T
authors.initials: T
authors.lastname: Kumazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Tetsuou
authors.forename: S
authors.initials: S
authors.lastname: Sakai
authors.forename: Y
authors.initials: Y
authors.lastname: Kusama
authors.forename: K
authors.initials: K
authors.lastname: Munakata
mesh_terms: D000368:Aged; D003652:Decanoic Acids; D005227:Fatty Acids; D005260:Female; D006321:Heart / Q000000981:diagnostic imaging*; D006801:Humans; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000000981:diagnostic imaging*; D017256:Technetium Tc 99m Sestamibi; D015899:Tomography, Emission-Computed, Single-Photon / Q000379:methods*
chemical_list: D003652:Decanoic Acids; D005227:Fatty Acids; D007457:Iodine Radioisotopes; D007462:Iodobenzenes; C049338:iodofiltic acid; D017256:Technetium Tc 99m Sestamibi