title: Comparative studies on the efficacy of sulphachlorpyrazine and toltrazuril for the treatment of caecal coccidiosis in chickens.
abstract: The therapeutic efficacy of sulphachlorpyrazine and toltrazuril against experimentally induced Eimeria tenella infection was compared in battery and floor pen raised broiler chickens. In the battery studies, both drugs prevented coccidiosis-related mortality and decrease of weight gain to a similar degree, but toltrazuril was more effective in reducing intestinal lesions and faecal scores, when treatments were initiated 24 h postinfection. When medication was delayed until 72 h after inoculation, the sulphonamide proved to be more effective in preventing reduction of weight gain and intestinal lesions caused by the parasites. Under simulated use conditions both drugs showed an appropriate anticoccidial efficacy without major differences between them.
authors.affiliation: Department of Pharmacology and Toxicology, University of Veterinary Science, Budapest, Hungary.
authors.forename: P
authors.initials: P
authors.lastname: Laczay
authors.forename: G
authors.initials: G
authors.lastname: Vörös
authors.forename: G
authors.initials: G
authors.lastname: Semjén
mesh_terms: D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002429:Cecal Diseases / Q000188:drug therapy / Q000469:parasitology / Q000662:veterinary*; D002645:Chickens / Q000469:parasitology*; D003048:Coccidiosis / Q000188:drug therapy / Q000662:veterinary*; D003049:Coccidiostats / Q000008:administration & dosage / Q000627:therapeutic use*; D016786:Eimeria tenella / Q000187:drug effects; D005260:Female; D008297:Male; D011201:Poultry Diseases / Q000188:drug therapy* / Q000469:parasitology; D013424:Sulfanilamides / Q000008:administration & dosage / Q000627:therapeutic use*; D014227:Triazines / Q000008:administration & dosage / Q000627:therapeutic use*; D000096926:Benzenesulfonamides
chemical_list: D003049:Coccidiostats; D013424:Sulfanilamides; D014227:Triazines; C050643:sulfachlorpyrazine; D000096926:Benzenesulfonamides; C036670:toltrazuril