title: Pharmacokinetics of zidovudine and dideoxyinosine alone and in combination in children with HIV infection.
abstract: The pharmacokinetics of zidovudine (ZDV) and dideoxyinosine (ddI) were investigated following administration alone and in combination to children with symptomatic HIV disease. The children were studied on three separate occasions and received ZDV 200 mg m-2, ddI 100 mg m2 or a combination of ZDV 200 mg m-2 plus ddI 100 mg m-2. The administration of ddI did not significantly alter ZDV pharmacokinetics. The area under the curve (AUC) was 14.2 +/- 4.9 and 15.8 +/- 7.2 mumol l-1 h and elimination half-life (t1/2, z) was 1.4 +/- 0.4 and 1.2 +/- 0.2 h in the absence and presence of ddI respectively. The peak concentration (Cmax), time to peak (tmax) and apparent oral clearance (CL/F) were also unchanged. The administration of ZDV had no significant effect on ddI Cmax, tmax, t1/2,z, or CL/F, however the AUC was reduced by 19% (5.9 +/- 2.9 to 4.8 +/- 2.7 mumol l-1 h; P < 0.05). This study suggests that ZDV and ddI may be co-administered to children with symptomatic HIV disease without concern of a clinically relevant pharmacokinetic drug interaction.
authors.affiliation: Institute of Child Health, University of London, UK.
authors.forename: D
authors.initials: D
authors.lastname: Gibb
authors.forename: M
authors.initials: M
authors.lastname: Barry
authors.forename: S
authors.initials: S
authors.lastname: Ormesher
authors.forename: L
authors.initials: L
authors.lastname: Nokes
authors.forename: M
authors.initials: M
authors.lastname: Seefried
authors.forename: C
authors.initials: C
authors.lastname: Giaquinto
authors.forename: D
authors.initials: D
authors.lastname: Back
mesh_terms: D000284:Administration, Oral; D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D016049:Didanosine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use; D004347:Drug Interactions; D004359:Drug Therapy, Combination; D015658:HIV Infections / Q000097:blood / Q000188:drug therapy / Q000378:metabolism*; D006207:Half-Life; D006801:Humans; D008297:Male; D011863:Radioimmunoassay; D015215:Zidovudine / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics* / Q000627:therapeutic use
chemical_list: D015215:Zidovudine; D016049:Didanosine