Treatment of Helicobacter pylori infection with a combination of itraconazole and omeprazole.
OBJECTIVE
To determine the in vivo anti-microbial activity of a high-dose itraconazole and omeprazole regimen against Helicobacter pylori.


METHODS
In an open pilot study, 10 H. pylori positive dyspeptic patients were treated with itraconazole 200 mg b.d. and omeprazole 200 mg b.d. for 7 days. Follow-up upper gastrointestinal endoscopy was performed 4-5 weeks after completion of therapy. Eradication of H. pylori infection was determined by histopathological examination and culture of biopsies from the antrum and corpus.


RESULTS
Eradication was not observed in any patient.


CONCLUSIONS
This combination of itraconazole with omeprazole does not eradicate H. pylori infection.
Keller
I J
IJ
Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.
van der Hulst
R W
RW
Tytgat
G N
GN
D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage*; D010865:Pilot Projects
D017964:Itraconazole; D009853:Omeprazole