[Assessment of lipid peroxidation in hyperbaric oxygen therapy: protective role of N-acetylcysteine].
OBJECTIVE
To verify and quantify lipidic peroxidation by means of tiobarbituric-acid reactive substance (TBARS) dosage in patients treated daily with HBO. To verify if a potentiated glutathione enzymatic system, with N-acetylcisteine (NAC) treatment, may determine higher HBO tolerance and reduced lipidic peroxidation.


METHODS
Randomised study on patients treated with 20 HBO 2.2 ATA (90' oxygen) sessions.


METHODS
Hyperbaric Medical Centre.


METHODS
Seventeen patients divided, at random, into two groups; group A: 10 patients treated with only HBO; group B: 7 patients treated with NAC antioxidant therapy (Fluimucil, Zambon Group, Italy) 1800 mg/day in addition to HBO.


METHODS
None.


RESULTS
TBARS on blood sample at T0 (basal) T1 (at the end of the 1st HBO session) T2 (at the beginning of the 20th HBO session) T3 (at the end of the 20th). The group A TBARS analysis at the different study time has shown significant data (p < 0.01) as the difference between TBARS values of the two groups at T2 (p < 0.01).


CONCLUSIONS
HBO induces a lipidic peroxidation even if the therapeutical protocol cannot determine lung or cerebral oxygen toxicity symptoms. The NAC administration, during HBO treatment, determines a protection against the HBO radicalic stress.
Pelaia
P
P
Istituto di Anestesiologia e Rianimazione, Università degli Studi di Roma, La Sapienza.
Rocco
M
M
De Blasi
R A
RA
Spadetta
G
G
Alampi
D
D
Araimo
F S
FS
Nicolucci
S
S
D000111:Acetylcysteine / Q000627:therapeutic use*; D006801:Humans; D006931:Hyperbaric Oxygenation; D015227:Lipid Peroxidation
D000111:Acetylcysteine
Valutazione della perossidazione lipidica in corso di ossigenoterapia iperbarica: ruolo protettivo della N-acetilcisteina.