Pristane-induced effects on cytochrome P-4501A, ornithine decarboxylase and putrescine in rats.
The effects of pristane (2,6,10,14-tetramethylpentadecane) on cytochrome P-4501A (cP4501A) activity in microsomes, as well as on ornithine decarboxylase (ODC) activity and concomitant putrescine levels were examined in Copenhagen rats. In general, pristane treatment led to increased cP4501A levels when compared to basal levels, while co-treatment with 3-methylcholanthrene (3-MC) and pristane elicited augmented cP4501A responses when compared to responses induced by 3-MC alone. Increases in both ODC activity and putrescine levels were also observed in pristane treated rats. Collectively, these results indicate that pristane influences cP4501A activity and elicits promoter-like responses as reflected in elevated ODC activity and increased amount of putrescine.
Harper
C M
CM
Department of Microbiology, University of Mississippi Medical Center, Jackson 39216-4505, USA.
Soni
M G
MG
Mehendale
H M
HM
Cuchens
M A
MA
D000818:Animals; D019363:Cytochrome P-450 CYP1A1; D003577:Cytochrome P-450 Enzyme System / Q000378:metabolism*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D008748:Methylcholanthrene / Q000494:pharmacology; D008861:Microsomes / Q000378:metabolism; D009955:Ornithine Decarboxylase / Q000378:metabolism*; D010088:Oxidoreductases / Q000378:metabolism*; D011700:Putrescine / Q000378:metabolism*; D051381:Rats; D013729:Terpenes / Q000494:pharmacology*; D014018:Tissue Distribution
D013729:Terpenes; C009042:pristane; D008748:Methylcholanthrene; D003577:Cytochrome P-450 Enzyme System; D010088:Oxidoreductases; D019363:Cytochrome P-450 CYP1A1; D009955:Ornithine Decarboxylase; D011700:Putrescine