title: Protein phosphorylation and regulation of carbon metabolism in gram-negative versus gram-positive bacteria.
abstract: Bacteria impose regulatory mechanisms on metabolic processes to ensure that the needs of the cell are met but not exceeded. Here, we discuss the basic features of a mechanism by which carbohydrate catabolism in Gram-positive bacteria is regulated. Although the physiological consequences of this regulation are the same as in Gram-negative bacteria, the mechanism is entirely different. These regulatory processes evidently evolved late, after the divergence of Gram-negative bacteria, even though the targets of regulation are universal.
authors.affiliation: Department of Biology, University of California at San Diego, La Jolla 92093-0116, USA.
authors.forename: M H
authors.initials: MH
authors.lastname: Saier
authors.forename: S
authors.initials: S
authors.lastname: Chauvaux
authors.forename: J
authors.initials: J
authors.lastname: Deutscher
authors.forename: J
authors.initials: J
authors.lastname: Reizer
authors.forename: J J
authors.initials: JJ
authors.lastname: Ye
mesh_terms: D001426:Bacterial Proteins / Q000378:metabolism*; D050260:Carbohydrate Metabolism; D029968:Escherichia coli Proteins; D006090:Gram-Negative Bacteria / Q000378:metabolism*; D006094:Gram-Positive Bacteria / Q000378:metabolism*; D026901:Membrane Transport Proteins / Q000378:metabolism; D009004:Monosaccharide Transport Proteins; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System / Q000378:metabolism; D010766:Phosphorylation; D015398:Signal Transduction / Q000502:physiology; D027981:Symporters
chemical_list: D001426:Bacterial Proteins; D029968:Escherichia coli Proteins; C050221:LacY protein, E coli; D026901:Membrane Transport Proteins; D009004:Monosaccharide Transport Proteins; D027981:Symporters; C021499:lactose permease; D010731:Phosphoenolpyruvate Sugar Phosphotransferase System