Chronic intrahepatic cholestasis in sickle cell disease requiring exchange transfusion.
A 15 year old boy with sickle cell disease developed intrahepatic cholestasis. A course of exchange transfusion successfully corrected the extreme hyperbilirubinaemia over one year. Upon stopping the exchange transfusion programme the hyperbilirubinaemia relapsed but transfusion was effective when reinstituted.
O'Callaghan
A
A
Department of Haematology, Royal Postgraduate Medical School, London.
O'Brien
S G
SG
Ninkovic
M
M
Butcher
G P
GP
Foster
C S
CS
Walters
J R
JR
Roberts
I A
IA
D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D002780:Cholestasis, Intrahepatic / Q000628:therapy*; D002908:Chronic Disease; D005078:Exchange Transfusion, Whole Blood; D006801:Humans; D006932:Hyperbilirubinemia / Q000628:therapy; D008297:Male; D012008:Recurrence