Increased prostacyclin content in gastric mucosa of cirrhotic patients with portal hypertensive gastropathy.
Plasma levels and gastric mucosal contents of prostaglandin (PG) E2 and prostacyclin were determined in cirrhotic patients with portal hypertensive gastropathy (PHG), in cirrhotic patients without PHG and in healthy controls. PGE2 and 6-keto-PGF1 alpha (a stable metabolite of prostacyclin) levels were measured in 30 cirrhotic patients and 10 controls, using radioimmunoassay. Of 30 cirrhotics, 13 had PHG of the fundus and the corpus. Plasma concentrations of 6-keto-PGF1 alpha in the cirrhotic patients were significantly higher than in the controls (p < 0.01), but there was no significant difference between cirrhotics and controls with regard to plasma levels of PGE2. The gastric mucosal contents of 6-keto-PGF1 alpha in the fundus was significantly higher in cirrhotics with PHG than those without PHG (p < 0.05) and controls (p < 0.01). However, the gastric mucosal contents of PGE2 in the fundus were not significantly different in cirrhotics with and without PHG. The gastric mucosal contents of 6-keto-PGF1 alpha significantly correlated to the plasma levels (r = 0.37, p < 0.05), but there was no significant correlation between plasma levels and gastric mucosal contents of PGE2. Since prostacyclin has vasodilator and gastric acid inhibitory effects, we speculate that high contents of prostacyclin in the gastric mucosa may have some role in the pathogenesis of PHG.
Ohta
M
M
Department of Surgery II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Kishihara
F
F
Hashizume
M
M
Kawanaka
H
H
Tomikawa
M
M
Higashi
H
H
Tanoue
K
K
Sugimachi
K
K
D015121:6-Ketoprostaglandin F1 alpha / Q000097:blood / Q000378:metabolism*; D000368:Aged; D015232:Dinoprostone / Q000097:blood / Q000378:metabolism; D005260:Female; D005748:Gastric Fundus / Q000378:metabolism; D005753:Gastric Mucosa / Q000378:metabolism*; D006801:Humans; D006975:Hypertension, Portal / Q000150:complications*; D007564:Japan; D008103:Liver Cirrhosis / Q000150:complications*; D008297:Male; D008875:Middle Aged; D013272:Stomach Diseases / Q000209:etiology* / Q000378:metabolism*
D015121:6-Ketoprostaglandin F1 alpha; D015232:Dinoprostone