n-Hexane-induced parkinsonism: pathogenetic hypotheses.
n-Hexane, similar hydrocarbons, and derivatives are common environmental pollutants and by-products of lipid peroxidation, and they may have a nigrotoxic effect like that of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. This report describes our second case of parkinsonism in a subject exposed to n-hexane. Positron emission tomography studies demonstrated regional striatal abnormalities of the nigrostriatal dopaminergic system and of glucose metabolism that were different from those found in idiopathic Parkinson's disease.
Pezzoli
G
G
Institute of Clinical Neurology, University of Milan, Italy.
Antonini
A
A
Barbieri
S
S
Canesi
M
M
Perbellini
L
L
Zecchinelli
A
A
Mariani
C B
CB
Bonetti
A
A
Leenders
K L
KL
D000395:Air Pollutants, Occupational / Q000009:adverse effects*; D001786:Blood Glucose / Q000378:metabolism; D001921:Brain / Q000000981:diagnostic imaging / Q000187:drug effects*; D001931:Brain Mapping; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000187:drug effects; D006586:Hexanes / Q000009:adverse effects*; D006801:Humans; D015227:Lipid Peroxidation / Q000187:drug effects / Q000502:physiology; D008297:Male; D008875:Middle Aged; D009460:Neurologic Examination / Q000187:drug effects; D009784:Occupational Diseases / Q000139:chemically induced* / Q000000981:diagnostic imaging; D010302:Parkinson Disease, Secondary / Q000139:chemically induced* / Q000000981:diagnostic imaging; D011954:Receptors, Dopamine / Q000187:drug effects / Q000502:physiology; D013378:Substantia Nigra / Q000000981:diagnostic imaging / Q000187:drug effects; D013633:Tanning; D014055:Tomography, Emission-Computed
D000395:Air Pollutants, Occupational; D001786:Blood Glucose; D006586:Hexanes; D011954:Receptors, Dopamine; C026385:n-hexane