title: Clastogenic activity of sodium fluoride in great ape cells.
abstract: Conflicting evidence has been reported concerning the mutagenicity of sodium fluoride (NaF), especially clastogenicity at concentrations of more than 1 mM. NaF is known to induce chromosome aberrations at these concentrations in human cells, but not in most rodent cells. We considered that such species-specific difference in chromosomal sensitivity would be derived from the phylogenetic distance between rodents and man. To clarify the role of interspecies differences, we investigated the chromosomal sensitivity to NaF in cell lines from various primates, which diverged into many species, including rodent-like prosimians and human-like great apes. The results showed that the clastogenicity of NaF was limited to human and great ape cells.
authors.affiliation: School of Health Sciences, Kyorin University, Tokyo, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Kishi
authors.forename: T
authors.initials: T
authors.lastname: Ishida
mesh_terms: D000818:Animals; D016466:CHO Cells; D002460:Cell Line; D016009:Chi-Square Distribution; D002869:Chromosome Aberrations; D006224:Cricetinae; D003412:Cricetulus; D005701:Galago / Q000235:genetics; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D007900:Lemur / Q000235:genetics; D009153:Mutagens / Q000633:toxicity*; D010802:Phylogeny; D012969:Sodium Fluoride / Q000633:toxicity*; D013045:Species Specificity
chemical_list: D009153:Mutagens; D012969:Sodium Fluoride