title: Altered MHC class I presented peptide repertoire is not sufficient to induce NK cell mediated F1-hybrid resistance.
abstract: Murine NK cells are known to mediate F1-hybrid anti-parental graft rejection responses. This phenomenon has been linked to the MHC, and in particular, to the alpha 1/alpha 2 domains of the MHC class I molecules. Here, we have addressed the role of MHC class I bound peptides in NK cell mediated F1-hybrid anti-parental rejection by studying the resistance of F1-hybrids between B6 and different bm mutant strains to B6-derived RBL-5 lymphoma cell line. Tumor development occurred at a similar frequency in all combinations of (B6 x bm)F1 mice and control B6 mice. These results suggest that absence of a specific MHC class I presented peptide repertoire on grafted cells is not sufficient to induce NK cell mediated F1-hybrid anti-parental rejection responses.
authors.affiliation: Microbiology and Tumor Biology Center, Karolinska Institute, Stockholm, Sweden.
authors.forename: M
authors.initials: M
authors.lastname: Salcedo
authors.forename: P
authors.initials: P
authors.lastname: Höglund
authors.forename: A
authors.initials: A
authors.lastname: Achour
authors.forename: C J
authors.initials: CJ
authors.lastname: Thorpe
authors.forename: H G
authors.initials: HG
authors.lastname: Ljunggren
mesh_terms: D000818:Animals; D017951:Antigen Presentation; D017690:Cell Transplantation; D002478:Cells, Cultured; D003198:Computer Simulation; D006084:Graft Rejection / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000235:genetics / Q000276:immunology*; D007111:Immunity, Cellular / Q000235:genetics; D007694:Killer Cells, Natural / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008810:Mice, Inbred C57BL; D008817:Mice, Mutant Strains; D016297:Mutagenesis, Site-Directed
chemical_list: D015395:Histocompatibility Antigens Class I