Uptake of 14C-chlorhexidine gluconate by Saccharomyces cerevisiae, Candida albicans and Candida glabrata.
Uptake of radiolabelled chlorhexidine gluconate (14C-CHG) to Saccharomyces cerevisiae, Candida albicans and C. glabrata was very rapid and near maximal within 30 s. The organism, S. cerevisiae, most sensitive to the lethal action of chlorhexidine, took up significantly more biocide than the other organisms. Cells from cultures of different ages took up different amounts of 14C-CHG.
Hiom
S J
SJ
Welsh School of Pharmacy, University of Wales College of Cardiff, UK.
Furr
J R
JR
Russell
A D
AD
D000891:Anti-Infective Agents, Local / Q000378:metabolism; D002175:Candida / Q000378:metabolism*; D002176:Candida albicans / Q000378:metabolism; D002250:Carbon Radioisotopes / Q000378:metabolism; D002710:Chlorhexidine / Q000031:analogs & derivatives* / Q000378:metabolism; D004305:Dose-Response Relationship, Drug; D007700:Kinetics; D012441:Saccharomyces cerevisiae / Q000378:metabolism*; D013997:Time Factors
D000891:Anti-Infective Agents, Local; D002250:Carbon Radioisotopes; C010882:chlorhexidine gluconate; D002710:Chlorhexidine