title: Effective argon-FRC with a rebreathing technique in children with acute asthma.
abstract: In children with asthma the measurement of functional residual capacity (FRC) with standard dilution techniques requires long rebreathing times of the inert gas, i.e., helium, to reach alveolar units with long time constants. A modification of the argon-freon-22 rebreathing technique enables argon to dilute in the readily accessible lung volume and potentially can give a measurement of FRC. However, the rebreathing tests cannot be prolonged for more than 1 min thus allowing argon to reach only the rapidly accessible lung units which are grossly useful in gas exchange (effective FRC, EFRC). The aim of this study was to measure the EFRC and standard lung function in children with acute severe asthma, assess their response to nebulized salbutamol, and evaluate the relations of the EFRC response to baseline spirometric measurements. Twenty-four asthmatic children who were admitted to the hospital with an acute asthma attack had spirometry and triplicate EFRC measurements before and after treatment with nebulized salbutamol. Eighteen patients had repeated the respiratory tests 50 days later when they had fully recovered. A significant proportion (28.9%) of the argon traces obtained at baseline before treatment did not equilibrate. However, in the great majority of these tests the oscillation of the argon traces over the last 3 breaths of the test was < 5% of the simultaneous argon concentration. The EFRC values derived from the argon traces with minimal oscillation (< 5%) were reduced during the acute asthma attack when compared with the paired values obtained after recovery (P = 0.03). The administration of salbutamol caused a fall from the baseline EFRC (P = 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Division of Paediatrics, United Medical School, Guy's Hospital, University of London, England.
authors.forename: P K
authors.initials: PK
authors.lastname: Yiallouros
authors.forename: A D
authors.initials: AD
authors.lastname: Milner
mesh_terms: D000208:Acute Disease; D000280:Administration, Inhalation; D000293:Adolescent; D000420:Albuterol / Q000008:administration & dosage / Q000627:therapeutic use*; D001128:Argon; D001249:Asthma / Q000175:diagnosis / Q000188:drug therapy* / Q000503:physiopathology*; D001993:Bronchodilator Agents / Q000008:administration & dosage / Q000627:therapeutic use*; D002648:Child; D002675:Child, Preschool; D005260:Female; D005652:Functional Residual Capacity; D006801:Humans; D016014:Linear Models; D008297:Male; D011659:Pulmonary Gas Exchange; D012115:Residual Volume / Q000502:physiology; D012119:Respiration; D012129:Respiratory Function Tests; D012680:Sensitivity and Specificity; D013147:Spirometry
chemical_list: D001993:Bronchodilator Agents; D001128:Argon; D000420:Albuterol