title: Effectiveness of mandatory transmissible diseases screening in Indian blood donors.
abstract: This study was undertaken to determine the prevalence of transfusion transmitted diseases (TTDs) among local blood donors, the safety offered by the four mandatory tests (for HIV, HBsAg, syphilis and malaria) and to assess alanine aminotransferase (ALT) as a surrogate test. A total of 313 blood donors were tested for HBsAg, hepatitis B core (HBc) antibody, hepatitis C (HCV) antibody, HIV antibody, and IgM antibody to cytomegalovirus (CMV-IgM). The serum alanine aminotransferase levels were also done on each unit of blood. The prevalence of various markers was 7(2.2%) for HBsAg, 57 (18.2%) for anti HBc (total), 1 (0.3%) for anti HCV, 16 (5.1%) for anti CMV. None of the donors were positive for HIV, VDRL or malaria. ALT level was raised in 16.5 per cent of donors and showed no correlation with hepatitis markers. ALT was not found to be useful as a surrogate marker for routine screening of donors. Sensitive tests like ELISA and immunofluoresence for malaria antigen should be applied for screening for malaria. VDRL test may be used to detect high risk donors rather than detection of syphilis when stored blood is used. HBsAg and HIV tests should be routinely done on every unit of blood and anti HCV tests should be done regularly, if possible.
authors.affiliation: Department of Transfusion Medicine, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow.
authors.forename: N
authors.initials: N
authors.lastname: Choudhury
authors.forename: V
authors.initials: V
authors.lastname: Ramesh
authors.forename: S
authors.initials: S
authors.lastname: Saraswat
authors.forename: S
authors.initials: S
authors.lastname: Naik
mesh_terms: D000328:Adult; D000410:Alanine Transaminase / Q000097:blood; D015415:Biomarkers / Q000097:blood; D001782:Blood Donors; D003586:Cytomegalovirus Infections / Q000453:epidemiology / Q000635:transmission; D018562:Disease Transmission, Infectious / Q000517:prevention & control*; D005260:Female; D015658:HIV Infections / Q000453:epidemiology / Q000635:transmission; D006509:Hepatitis B / Q000453:epidemiology / Q000635:transmission; D006526:Hepatitis C / Q000453:epidemiology / Q000635:transmission; D006801:Humans; D007194:India; D008288:Malaria / Q000453:epidemiology / Q000635:transmission; D008297:Male; D008403:Mass Screening; D008875:Middle Aged; D015995:Prevalence; D065227:Transfusion Reaction
chemical_list: D015415:Biomarkers; D000410:Alanine Transaminase