title: Behçet's disease.
abstract: The reliability and ease of use of any activity form has to be balanced against the content validity of the questions being asked. Clinical experience over several years suggests that presence of a high disease activity score is consistent both with the clinician's and patient's overall impression of disease activity. If the onset of the more serious manifestations can be predicted by more readily measured symptoms such as oral and genital ulceration, skin lesions, arthritis and superficial thrombophlebitis, then these organ system subscores could be expanded to provide a more accurate representation of activity. Other organ systems such as auditory system may also provide a measure of disease activity. For the purpose of clinical trials it is likely that if treatment is targeted at a specific organ system then a more comprehensive measure of activity within that organ system would have to be used (e.g. the role of thalidomide in oral ulceration) (Revuz et al, 1990). This would require the use of a form which measured many facets of oral ulceration (duration of ulcers, number of ulcers, size of ulcers, number of crops of ulcers, site of ulcers, etc). However it is recommended that such a form should be used in conjunction with a validated general disease activity form to alert the clinician conducting any trials of the advantageous or deleterious effects of the trial drug on other organ systems.
authors.affiliation: Nuffield Institute for Health, University of Leeds, UK.
authors.forename: A S
authors.initials: AS
authors.lastname: Rigby
authors.forename: M A
authors.initials: MA
authors.lastname: Chamberlain
authors.forename: B
authors.initials: B
authors.lastname: Bhakta
mesh_terms: D001528:Behcet Syndrome / Q000145:classification* / Q000175:diagnosis / Q000503:physiopathology; D006304:Health Status; D006801:Humans; D007391:International Cooperation; D012219:Rheumatology / Q000379:methods / Q000639:trends