Pharmacokinetics/pharmacodynamics of CI-1000, a purine nucleoside phosphorylase (PNP) inhibitor, in rats and monkeys.
Hallak
H
H
Parke-Davis Pharmaceutical Research, Warner-Lambert Company, Ann Arbor, MI 48105, USA.
Hayes
A
A
Dong
M
M
Gilbertsen
R
R
Guttendorf
R
R
D000818:Animals; D001682:Biological Availability; D005260:Female; D006147:Guanine / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology; D007288:Inosine / Q000097:blood*; D008252:Macaca fascicularis; D008297:Male; D008657:Metabolic Clearance Rate; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*; D051381:Rats; D017208:Rats, Wistar; D013045:Species Specificity
C076778:9-deaza-9-(3-thienylmethyl)guanine; D007288:Inosine; D006147:Guanine; D011683:Purine-Nucleoside Phosphorylase