Neonatal haemochromatosis associated with Down syndrome.
METHODS
The clinical course of a child with neonatal haemochromatosis associated with Down syndrome is described, using case notes and post-mortem examination.


RESULTS
The patient died of liver failure on day 36. Post-mortem examination showed siderosis of liver, pancreas, heart, kidney and thyroid.


CONCLUSIONS
Neonatal haemochromatosis is a rare paediatric disease, the aetiology of which is unknown. Evidence suggests a disorder of fetoplacental iron handling with implications for recurrence in future pregnancies.
Cheung
P C
PC
Department of Paediatrics, Caritas Medical Centre, Shamshuipo, Kowloon, Hong Kong.
Ng
W F
WF
Chan
A K
AK
D004314:Down Syndrome / Q000150:complications* / Q000473:pathology; D017809:Fatal Outcome; D005260:Female; D006432:Hemochromatosis / Q000150:complications* / Q000473:pathology*; D006801:Humans; D007231:Infant, Newborn; D017093:Liver Failure / Q000209:etiology