title: Clinical significance of longitudinal complement measurements in recipients of bone marrow transplant.
abstract: Overall activity of classical complement pathway, C3 and C4 levels, level of circulating immune complexes and concentration of serum immunoglobulins were measured in 38 patients transplanted with HLA-identical bone marrow before and after transplantation for at least 4 years. Changes of complement parameters and their association with acute and chronic GVHD and with infections were analysed. A strong association was found between the development of chronic GVHD and hypercomplementaemia measured in 16 long-term survivors. Low pre-transplantation C4 activity was found to predict the development of severe acute GVHD. These findings indicate that longitudinal complement measurements may have clinical value in BMT patients.
authors.affiliation: National Institute of Haematology and Blood Transfusion, Budapest, Hungary.
authors.forename: L
authors.initials: L
authors.lastname: Varga
authors.forename: A
authors.initials: A
authors.lastname: Poros
authors.forename: E
authors.initials: E
authors.lastname: Puskás
authors.forename: A
authors.initials: A
authors.lastname: Pánya
authors.forename: J
authors.initials: J
authors.lastname: Kramer
authors.forename: E
authors.initials: E
authors.lastname: Gyódi
authors.forename: G
authors.initials: G
authors.lastname: Füst
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000936:Antigen-Antibody Complex / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D016026:Bone Marrow Transplantation / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D002908:Chronic Disease; D003176:Complement C3 / Q000378:metabolism*; D003181:Complement C4 / Q000378:metabolism*; D003171:Complement Pathway, Classical / Q000276:immunology; D005260:Female; D005500:Follow-Up Studies; D006086:Graft vs Host Disease / Q000276:immunology*; D006402:Hematologic Diseases / Q000276:immunology / Q000628:therapy; D006650:Histocompatibility Testing; D006801:Humans; D007136:Immunoglobulins / Q000097:blood*; D007239:Infections / Q000276:immunology; D008297:Male; D008875:Middle Aged; D012189:Retrospective Studies; D014184:Transplantation, Homologous
chemical_list: D000936:Antigen-Antibody Complex; D015415:Biomarkers; D003176:Complement C3; D003181:Complement C4; D007136:Immunoglobulins