title: Columbin isolated from calumbae radix affects the sleeping time of anesthetized mice.
abstract: In a screening series of bioactive components in edible and medicinal plants, we found that Calumbae Radix (Colombo root, 1% powdered feed, for 5 d) and its component, columbin (20-40 mg/kg/d, for 5 d, orally), shortened the sleeping time induced by a urethane and alpha-chloralose mixture and prolonged the sleeping time induced by hexobarbital in mice.
authors.affiliation: Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Wada
authors.forename: T
authors.initials: T
authors.lastname: Kurihara
authors.forename: M
authors.initials: M
authors.lastname: Yagi
authors.forename: R
authors.initials: R
authors.lastname: Kobayashi
authors.forename: H
authors.initials: H
authors.lastname: Kaminaga
authors.forename: K
authors.initials: K
authors.lastname: Toi
authors.forename: M
authors.initials: M
authors.lastname: Haga
mesh_terms: D000758:Anesthesia; D000818:Animals; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006591:Hexobarbital / Q000494:pharmacology; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors; D014520:Urethane / Q000494:pharmacology
chemical_list: D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D007783:Lactones; D010936:Plant Extracts; D014520:Urethane; D006591:Hexobarbital; C062514:columbin