title: [Coronary sinus blood flow after intracoronary or intravenous administration of bisoprolol in coronary disease].
abstract: OBJECTIVE
  To measure changes in haemodynamics and myocardial blood flow after acute intravenous (i.v.) and intracoronary (i.c.) injection of bisoprolol in patients with coronary heart disease.
  
  
  METHODS
  A prospective, randomized controlled study of 14 patients (12 men, 2 women; mean age 65 [50-73] years) with angio-graphically proven coronary artery stenosis (reduced in lumen of at least 70%) in one or more major vessels. Seven patients received, before balloon angioplasty, either 0.01 mg/kg body weight directly into the coronaries (group 1, infusion through the guiding catheter) or 2.5 mg (group 2, via the sheath). Heart rate and blood pressure were measured before and after bisoprolol injection. Coronary blood flow was measured by the thermodilution method via two indwelling catheters in the coronary sinus.
  
  
  RESULTS
  After bisoprolol there was a reduction in heart rate (group 1: from 83/min to 75/min; group 2: from 77/min to 72/min) and blood pressure (group 1: from 137/80 mm Hg to 125/70 mm Hg; group 2: from 135/86 mm Hg to 126/80 mm Hg). Coronary blood flow was lower after i.c. bisoprolol injection than before (group 1: 383 ml/min vs 352 ml/min, but higher after i.v. injection (group 2: 353 ml/min vs 384 ml/min). These differences were statistically not significant.
  
  
  CONCLUSIONS
  While after-load was clearly reduced and myocardial blood flow remained unchanged, bisoprolol improved myocardial oxygen balance. No different effects could be detected after intracoronary vs intravenous application of bisoprolol.
authors.affiliation: Medizinische Klinik, Universität München.
authors.forename: P
authors.initials: P
authors.lastname: Gonschior
authors.forename: M
authors.initials: M
authors.lastname: Fleuchaus
authors.forename: K
authors.initials: K
authors.lastname: Larisch
authors.forename: A
authors.initials: A
authors.lastname: Stäblein
authors.forename: B
authors.initials: B
authors.lastname: Höfling
mesh_terms: D000368:Aged; D017298:Bisoprolol / Q000008:administration & dosage* / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects; D003326:Coronary Circulation / Q000187:drug effects*; D003327:Coronary Disease / Q000188:drug therapy* / Q000503:physiopathology; D003331:Coronary Vessels; D003627:Data Interpretation, Statistical; D005260:Female; D006339:Heart Rate / Q000187:drug effects; D006801:Humans; D007269:Injections, Intra-Arterial; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D017298:Bisoprolol
vernacular_title: Koronarsinusdurchblutung nach intrakoronarer oder intravenöser Gabe von Bisoprolol bei koronarer Herzkrankheit.