title: Links between prolonged exposure to xenobiotics, increased incidence of hepatopathies, immunological disturbances and exacerbation of latent Epstein-Barr virus infections.
abstract: Disturbances of several humoral and cellular immune parameters are significantly increased in individuals exposed to chemical pollutants. Moreover, exacerbations of the latent Epstein-Barr virus (EBV) infection were more frequently observed in the chemically exposed group than in the control groups. A significant correlation was seen between EBV exacerbations and the increased number of eosinophils, T-lymphocyte rosette formation and the respiratory burst of polymorphonuclear blood cells. Possible links between hepatopathy due to xenobiotics exposition, immunological disturbances and EBV exacerbation are discussed, including a putative role of EBV-induced (autocrine) cytokines.
authors.affiliation: Institute of Preventive and Clinical Medicine, Bratislava, Slovak Republic.
authors.forename: D
authors.initials: D
authors.lastname: Stancek
authors.forename: G
authors.initials: G
authors.lastname: Kosecká
authors.forename: M
authors.initials: M
authors.lastname: Oltman
authors.forename: A
authors.initials: A
authors.lastname: Keleová
authors.forename: E
authors.initials: E
authors.lastname: Jahnová
mesh_terms: D000914:Antibodies, Viral / Q000097:blood; D000917:Antibody Formation / Q000187:drug effects*; D000956:Antigens, Viral / Q000276:immunology; D002617:Chemical Industry; D056486:Chemical and Drug Induced Liver Injury; D016207:Cytokines / Q000502:physiology; D004581:Electronics; D004785:Environmental Pollutants / Q000009:adverse effects* / Q000494:pharmacology; D006526:Hepatitis C / Q000276:immunology; D006566:Herpesviridae Infections / Q000276:immunology*; D004854:Herpesvirus 4, Human / Q000187:drug effects* / Q000276:immunology / Q000502:physiology; D006801:Humans; D007111:Immunity, Cellular / Q000187:drug effects*; D016867:Immunocompromised Host; D018448:Models, Immunological; D009784:Occupational Diseases / Q000139:chemically induced* / Q000276:immunology; D016273:Occupational Exposure; D016877:Oxidants / Q000009:adverse effects* / Q000494:pharmacology; D018384:Oxidative Stress; D016897:Respiratory Burst; D012189:Retrospective Studies; D013997:Time Factors; D014775:Virus Activation / Q000187:drug effects*; D015262:Xenobiotics / Q000009:adverse effects* / Q000494:pharmacology
chemical_list: D000914:Antibodies, Viral; D000956:Antigens, Viral; D016207:Cytokines; D004785:Environmental Pollutants; D016877:Oxidants; D015262:Xenobiotics