Cardiovascular risk factors and alcohol consumption in France and Northern Ireland.
The levels of different lipid, lipoprotein and haemostatic variables were assessed in 615 control subjects of the ECTIM Study, defined by five groups of alcohol consumption: non-drinkers, 0 < or = 15 g/day, 15 < . < or = 36 g/day, 36 < . < or = 66 g/day and > 66 g/day. After adjustment for age, body mass index, cigarette consumption and country, alcohol consumption was associated with an increase in HDL-cholesterol (0.47 +/- 0.02 to 0.59 +/- 0.01 g/l in non-drinkers and > 66 g/day consumers, mean +/- S.E.M., P < 0.0001), apolipoproteins A-I and A-II (1.37 +/- 0.03 to 1.60 +/- 0.03 g/l and 0.32 +/- 0.01 to 0.41 +/- 0.01 g/l, respectively, P < 0.0001), LpA-I, LpA-I:A-II (0.46 +/- 0.01 to 0.50 +/- 0.01 g/l and 0.75 +/- 0.02 to 0.91 +/- 0.02 g/l, respectively, P < 0.001) and PAi-1 activity (134 +/- 11 to 177 +/- 11 U/ml, P < 0.001). Conversely, no increases were found for total and LDL-cholesterol, triglycerides, apolipoproteins B and C-III, LpE:B, LpC-III:B, fibrinogen and factor VII. Hence, among the lipid and haemostatic variables studied, only HDL parameters and PAi-1 activity were increased by alcohol consumption.
Marques-Vidal
P
P
MONICA-Toulouse, INSERM U326-ORSMIP, C.H.U. Purpan, France.
Cambou
J P
JP
Nicaud
V
V
Luc
G
G
Evans
A
A
Arveiler
D
D
Bingham
A
A
Cambien
F
F
D000328:Adult; D000428:Alcohol Drinking / Q000097:blood* / Q000503:physiopathology; D001053:Apolipoproteins / Q000097:blood; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D005602:France / Q000453:epidemiology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D009660:Northern Ireland / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors
D001053:Apolipoproteins; D008055:Lipids; D008074:Lipoproteins; D002784:Cholesterol