Higher-order nucleoprotein complexes in transcription: analogies with site-specific recombination.
Regulation of transcription involves the assembly of multiprotein complexes at enhancers and promoters. Interactions between adjacent and non-adjacent DNA-binding proteins can augment the specificity and stability of multi-component nucleoprotein complexes. Recently, several proteins have been identified that can function as 'architectural' elements in the assembly of higher-order nucleoprotein structures reminiscent of those involved in site-specific recombination in prokaryotes.
Grosschedl
R
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Howard Hughes Medical Institute, Department of Microbiology, University of California, San Francisco 94143-0414, USA.
D000818:Animals; D004247:DNA / Q000737:chemistry / Q000235:genetics; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism; D004742:Enhancer Elements, Genetic; D016762:Genes, fos; D006609:High Mobility Group Proteins / Q000235:genetics / Q000378:metabolism; D006801:Humans; D016899:Interferon-beta / Q000235:genetics; D046911:Macromolecular Substances; D008957:Models, Genetic; D009690:Nucleic Acid Conformation; D009698:Nucleoproteins / Q000235:genetics* / Q000378:metabolism; D011995:Recombination, Genetic; D014158:Transcription, Genetic
D004268:DNA-Binding Proteins; D006609:High Mobility Group Proteins; D046911:Macromolecular Substances; D009698:Nucleoproteins; D016899:Interferon-beta; D004247:DNA