[Effectiveness of oxytetracycline and chingamin on cold injury in rats].
The preventive and therapeutical effects of oxytetracycline hydrochloride, 10 mg/kg b.w., and chingamine, 50 mg/kg b.w., were studied in frostbites caused by ethyl chloride. The experiments were conducted on adult albino Wistar rats. The two drugs given orally twice a day for 15 days or more prevented the development of frost bite; clinical, biochemical, and histological parameters becoming normal. Chingamine was found to be more effective, which makes it promising for further experimental and clinical studies.
Aleutskiĭ
N N
NN
Buiuklinskaia
O V
OV
Malykh
E A
EA
Nazarenko
N A
NA
D000818:Animals; D002738:Chloroquine / Q000627:therapeutic use*; D005627:Frostbite / Q000188:drug therapy*; D008297:Male; D010118:Oxytetracycline / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar
D002738:Chloroquine; D010118:Oxytetracycline
Effektivnost' oksitetratsiklina i khingamina pri kholodovoĭ travme u krys.