[Comparison between ranitidine, famotidine, and omeprazole in the treatment of bleeding duodenal ulcer].
A trial was carried out to compare the efficacy and safety of ranitidine 300 mg die, famotidine 40 mg die and omeprazole 20 mg die in short-term treatment of bleeding duodenal ulcer in 3 groups of 15 patients. The healing rates after 2.4 weeks were 33.60% respectively with ranitidine, 40, 70% respectively with famotidine and 53, 93% respectively with omeprazole. All the drugs were well tolerated and the adverse events were infrequent and moderate. The recurrence rates after 6, 12 months were 20, 33% respectively with ranitidine, 13, 20% respectively with famotidine and only 7, 13% respectively with omeprazole. In our experience, omeprazole seems to be superior to famotidine and to ranitidine in the short-term treatment of bleeding duodenal ulcer, with the shortest relapse rate.
Maculotti
L
L
Divisione di Chirurgia Generale Andrea Ponti, Ospedale Niguarda Ca' Granda, Milano.
Pradella
P
P
D004381:Duodenal Ulcer / Q000188:drug therapy*; D015738:Famotidine / Q000627:therapeutic use*; D006801:Humans; D009853:Omeprazole / Q000627:therapeutic use*; D010438:Peptic Ulcer Hemorrhage / Q000188:drug therapy*; D011899:Ranitidine / Q000627:therapeutic use*
D015738:Famotidine; D011899:Ranitidine; D009853:Omeprazole
Confronto tra ranitidina, famotidina e omeprazolo nel trattamento dell'ulcera duodenale sanguinante.