title: [The expressions of proliferating cell nuclear antigen (PCNA) in primary gallbladder carcinoma and its significance].
abstract: Anti-PCNA monoclonal antibody and ABC staining were used to study the expressions of proliferating cell nuclear antigen/cyclin in patients with primary gallbladder carcinoma (31 cases), adenoma and tumor-like lesions of gallbladder (10 cases), and chronic cholecystitis (7 cases). The PCNA indices were 373.48 +/- 219.83, 94.9 +/- 93, and 56 +/- 28.63, respectively. This index was significantly higher in malignant lesions than in benign diseases (P < 0.01). There was a tendency that the higher the PCNA index, the lower differential degree of the gallbladder carcinoma (P < 0.01). But there were no significant correlations between the PCNA indices and the pathohistological types, the nevin classifications and the TNM classifications of the gallbladder carcinoma (P > 0.05).
authors.affiliation: Affiliated Hospital of Guiyang Medical College.
authors.forename: D
authors.initials: D
authors.lastname: Qing
authors.forename: L
authors.initials: L
authors.lastname: Xia
authors.forename: X
authors.initials: X
authors.lastname: Zhang
mesh_terms: D000230:Adenocarcinoma / Q000276:immunology* / Q000473:pathology; D000231:Adenocarcinoma, Papillary / Q000276:immunology / Q000473:pathology; D000236:Adenoma / Q000276:immunology / Q000473:pathology; D002764:Cholecystitis / Q000276:immunology; D005706:Gallbladder Neoplasms / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*
chemical_list: D018809:Proliferating Cell Nuclear Antigen