title: Simultaneous occurrence of tetrasomy 21 and trisomy 8 in a patient with early blastic metamorphosis of chronic myeloproliferative disorder.
abstract: We report an unusual hyperdiploid karyotype characterized by the simultaneous occurrence of tetrasomy 21 and trisomy 8 detected during early blastic evolution of a BCR-ABL-negative chronic myeloproliferative disorder. Blast cells from this patient showed a striking response to all-trans-retinoic acid (ATRA)-induced differentiation as evaluated by CD15 expression following in vitro exposure to this inducer. Our report represents the first description of such a composite karyotype in human hematologic malignancies.
authors.affiliation: Servizio Di Genetica Medica, Ospedale Cardarelli, Napoli, Italia.
authors.forename: L
authors.initials: L
authors.lastname: Sebastio
authors.forename: F
authors.initials: F
authors.lastname: Ferrara
authors.forename: L
authors.initials: L
authors.lastname: Vicari
authors.forename: R
authors.initials: R
authors.lastname: di Noto
authors.forename: L
authors.initials: L
authors.lastname: del Vecchio
authors.forename: F
authors.initials: F
authors.lastname: Pane
authors.forename: A
authors.initials: A
authors.lastname: Fasanaro
authors.forename: R
authors.initials: R
authors.lastname: Cimino
authors.forename: F
authors.initials: F
authors.lastname: Salvatore
authors.forename: V
authors.initials: V
authors.lastname: Ventruto
mesh_terms: D000368:Aged; D000782:Aneuploidy; D001853:Bone Marrow / Q000276:immunology / Q000473:pathology; D002454:Cell Differentiation / Q000187:drug effects; D002478:Cells, Cultured; D002891:Chromosomes, Human, Pair 21 / Q000235:genetics*; D002898:Chromosomes, Human, Pair 8 / Q000235:genetics*; D002908:Chronic Disease; D006801:Humans; D016130:Immunophenotyping; D007621:Karyotyping; D008297:Male; D009196:Myeloproliferative Disorders / Q000150:complications* / Q000235:genetics; D011003:Ploidies; D014212:Tretinoin / Q000494:pharmacology; D014314:Trisomy
chemical_list: D014212:Tretinoin