[Effect of selective activation and blockade of the central dopaminergic system on the course of the early post-traumatic period].
Acute experiments on white rats traumatized according to Kenon demonstrated that the central administration of the dopamine receptor agonist apomorphine led a reduction in mortality rates and an increase in stroke and heart indices. The latter was due to the significant activation of the hypothalamo-hypophysis-thyroidal system. The use of sulpiride as a specific dopamine receptor blocker increased mortality rates and decreased stroke and heart indices. This was accompanied by the maximum activation of the hypothalamo-neurohypophyseal system.
Barinov
E F
EF
Abramets
I I
II
Ziablitsev
S V
SV
D000818:Animals; D018491:Dopamine Agonists / Q000627:therapeutic use*; D018492:Dopamine Antagonists / Q000627:therapeutic use*; D008297:Male; D051381:Rats; D013313:Stress Disorders, Post-Traumatic / Q000188:drug therapy*; D013997:Time Factors
D018491:Dopamine Agonists; D018492:Dopamine Antagonists
Vliianie selektivnoĭ aktivatsii i blokady tsentral'nykh dofaminergicheskikh sistem na techenie rannego posttravmaticheskogo perioda.