title: Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians.
abstract: As part of a community-based study of Alzheimer's Disease (AD) in a Nigerian population aged 65 years and over, we have determined apolipoprotein E (APOE) genotypes on 56 subjects (39 controls and 17 subjects with dementia, including 12 with AD). The epsilon 4 allele of APOE was not associated with AD or dementia in this community-based sample. The epsilon 4 allele frequency was 17.6% in demented patients and 16.7% in AD patients compared with 20.5% in the control subjects. These findings are in marked contrast to the strong association between the epsilon 4 allele and AD in our previously reported study with African Americans.
authors.affiliation: Department of Medicine, University of Ibadan, Nigeria.
authors.forename: B O
authors.initials: BO
authors.lastname: Osuntokun
authors.forename: A
authors.initials: A
authors.lastname: Sahota
authors.forename: A O
authors.initials: AO
authors.lastname: Ogunniyi
authors.forename: O
authors.initials: O
authors.lastname: Gureje
authors.forename: O
authors.initials: O
authors.lastname: Baiyewu
authors.forename: A
authors.initials: A
authors.lastname: Adeyinka
authors.forename: S O
authors.initials: SO
authors.lastname: Oluwole
authors.forename: O
authors.initials: O
authors.lastname: Komolafe
authors.forename: K S
authors.initials: KS
authors.lastname: Hall
authors.forename: F W
authors.initials: FW
authors.lastname: Unverzagt
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D003625:Data Collection; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D009549:Nigeria
chemical_list: D053327:Apolipoprotein E4; D001057:Apolipoproteins E