Antifungal agents. 10. Synthesis and antifungal activities of aryl-(1H-imidazol-1-yl)-(isoquinolin-1-yl) methane derivatives.
Various aryl-(1H-imidazol-1-yl)-(isoquinolin-1-yl)methane derivatives have been synthesized and tested as antifungal agents. The new imidazoles have been obtained by the action of 1,1'-sulfinyldiimidazole on aryl-(isoquinolin-1-yl)carbinols, which have been prepared by standard procedures starting from isoquinoline. Among 44 test derivatives only a few have exhibited some antifungal activity, the most active compound (4e) being twofold less potent than miconazole, ketoconazole and bifonazole, used as standard drugs.
Silvestri
R
R
Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza, Roma, Italy.
Pagnozzi
E
E
Troccoli
F
F
Stefancich
G
G
Massa
S
S
Apuzzo
G
G
Perazzi
M E
ME
Artico
M
M
Simonetti
G
G
D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D007546:Isoquinolines / Q000138:chemical synthesis / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
D000935:Antifungal Agents; D007093:Imidazoles; D007546:Isoquinolines