title: [Disruption of molecular mechanisms of cell adhesion in murine liver in genetic predisposition to spontaneous blastomogenesis].
abstract: Macromolecular adhesion factors (MAFs) were obtained from the liver of mice with a genetic predisposition for spontaneous hepatoblastomogenesis (CBA) and of resistant mice (C57B1). The MAFs from the liver of both strains are similar in their chemical nature and represents a complex of phosphoglycopeptides with a molecular mass of 20-40 kDa and glycosaminoglycans. The discovered basic difference in the biological effect of MAFs of these strains on the adhesion of hepatocytes appears to be due to disturbances of MAF glycosylation in CBA mice, which cause changes in the spatial-functional organization of the adhesion site in the hepatocytes.
authors.forename: N B
authors.initials: NB
authors.lastname: Tumanova
authors.forename: V P
authors.initials: VP
authors.lastname: Iamskova
mesh_terms: D000818:Animals; D002448:Cell Adhesion / Q000235:genetics*; D015815:Cell Adhesion Molecules / Q000737:chemistry / Q000302:isolation & purification / Q000378:metabolism; D020022:Genetic Predisposition to Disease; D006025:Glycosaminoglycans / Q000378:metabolism; D006031:Glycosylation; D018197:Hepatoblastoma / Q000235:genetics*; D008113:Liver Neoplasms / Q000235:genetics*; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008808:Mice, Inbred CBA; D013045:Species Specificity
chemical_list: D015815:Cell Adhesion Molecules; D006025:Glycosaminoglycans
vernacular_title: Narushenie molekuliarnykh mekhanizmov kletochnoĭ adgezii v pecheni mysheĭ pri geneticheskoĭ predraspolozhennosti k spontannomu blastomogenezu.