title: Tumour uptake of 57-cobalt-bleomycin in patients with breast cancer.
abstract: 17 patients with breast carcinoma were studied with 57-cobalt-bleomycin scintigraphy. Scans showed increased tumour uptake in all patients. Results expressed as percentage of the injected dose (ID) normalised by the size of the tumour region (% ID/pixel) showed higher tumour uptake in patients with T3-T4 breast carcinomas (n = 5) than in patients with T1-T2 breast cancer (n = 12) (8.4 +/- 0.55 x 10(-3) vs. 5.25 +/- 1.71 x 10(-3)% ID/pixel, respectively, P < 0.05). An inverse correlation between tumour uptake of 57-cobalt-bleomycin and progesterone receptor concentration was also found in all tumours tested (r = -0.60, P < 0.05, n = 10) and was confirmed in the group of patients with T2 breast carcinomas (r = -0.89, P < 0.05, n = 6). We conclude that a quantitative analysis of 57-cobalt-bleomycin uptake can give additional information suitable for the presurgical characterisation of a tumour.
authors.affiliation: Cattedra di Medicina Nucleare, II Facoltà di Medicina, Università Federico II, Napoli, Italy.
authors.forename: L
authors.initials: L
authors.lastname: Pace
authors.forename: G
authors.initials: G
authors.lastname: D'Aiuto
authors.forename: C
authors.initials: C
authors.lastname: Acampora
authors.forename: P
authors.initials: P
authors.lastname: Oliviero
authors.forename: G
authors.initials: G
authors.lastname: Botti
authors.forename: F
authors.initials: F
authors.lastname: Tatangelo
authors.forename: M
authors.initials: M
authors.lastname: Cerra
authors.forename: M
authors.initials: M
authors.lastname: Salvatore
mesh_terms: D000328:Adult; D000368:Aged; D001761:Bleomycin / Q000493:pharmacokinetics*; D001943:Breast Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism*; D002277:Carcinoma / Q000000981:diagnostic imaging / Q000378:metabolism*; D002285:Carcinoma, Intraductal, Noninfiltrating / Q000000981:diagnostic imaging / Q000378:metabolism*; D003037:Cobalt Radioisotopes; D005260:Female; D006801:Humans; D008875:Middle Aged; D011877:Radionuclide Imaging; D011960:Receptors, Estrogen / Q000032:analysis; D011980:Receptors, Progesterone / Q000032:analysis
chemical_list: D003037:Cobalt Radioisotopes; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; D001761:Bleomycin