title: Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice.
abstract: We report the unprecedented finding of a gene with a different map position in two mouse strains. The Clcn4 gene was found to map to the X chromosome in the wild Mediterrean mouse, Mus spretus but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region. Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.
authors.affiliation: Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milano, Italy.
authors.forename: E I
authors.initials: EI
authors.lastname: Rugarli
authors.forename: D A
authors.initials: DA
authors.lastname: Adler
authors.forename: G
authors.initials: G
authors.lastname: Borsani
authors.forename: K
authors.initials: K
authors.lastname: Tsuchiya
authors.forename: B
authors.initials: B
authors.lastname: Franco
authors.forename: X
authors.initials: X
authors.lastname: Hauge
authors.forename: C
authors.initials: C
authors.lastname: Disteche
authors.forename: V
authors.initials: V
authors.lastname: Chapman
authors.forename: A
authors.initials: A
authors.lastname: Ballabio
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D005075:Biological Evolution; D018118:Chloride Channels / Q000235:genetics*; D002874:Chromosome Mapping; D017931:DNA Primers; D005260:Female; D015321:Gene Rearrangement; D006801:Humans; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D009115:Muridae; D017386:Sequence Homology, Amino Acid; D013045:Species Specificity; D014960:X Chromosome
chemical_list: C097503:CLC-5 chloride channel; C484312:CLCN4 protein, human; D018118:Chloride Channels; D017931:DNA Primers