title: Effect of thyroid replacement therapy on the stature of Colombian children with minimal thyroid dysfunction.
abstract: The effect of thyroid replacement therapy (TRT) was evaluated in 372 children with minimal thyroid dysfunction (MTD; augmented TSH response to TRH, deficient iodine consumption, goiter, short stature and retarded bone age), by comparison of pre- with post-observation height in periods of 6 months with and without TRT alternated. A significant (P < 0.05) height recovery was observed when children received TRT; however, during the period without TRT they showed a negative height recovery. Additionally, we followed 51 children with MTD who were observed from Tanner I until final height. The group with L-thyroxine (n = 43) during all follow-up (97 months) showed an important recovery in height (SDS-H = 1.67 +/- 0.93 vs. 1.08 +/- 0.74) which when compared with the untreated group (n = 8; 114 months; SDS-H = -1.50 +/- 0.83 vs. -1.93 +/- 0.33) was significant (P < 0.001).
authors.affiliation: Universidades del Norte y Metropolitana, Barranquilla, Colombia.
authors.forename: C
authors.initials: C
authors.lastname: Hernández-Cassis
authors.forename: C
authors.initials: C
authors.lastname: Cure-Cure
authors.forename: P
authors.initials: P
authors.lastname: López-Jaramillo
mesh_terms: D001827:Body Height; D002648:Child; D002675:Child, Preschool; D005260:Female; D006128:Growth; D006801:Humans; D008297:Male; D013959:Thyroid Diseases / Q000188:drug therapy* / Q000503:physiopathology; D013974:Thyroxine / Q000627:therapeutic use*
chemical_list: D013974:Thyroxine