title: Proton MRS of gadolinium-enhancing MS plaques and metabolic changes in normal-appearing white matter.
abstract: Localized short echo time (TE = 20 ms), stimulated echo acquisition mode, and double spin echo (TE = 135 ms) proton spectroscopy were performed in clearly defined, acute Gadolinium (Gd)-enhancing multiple sclerosis (MS) plaques of 22 patients with clinically definite MS. The resonances of N-acetylated metabolites (NA), creatine/phosphocreatine (Cr), choline-containing compounds (Cho), glycine/myo-inositol (Ino), and lactate were evaluated. The ratios of NA/Cr and NA/Cho were significantly decreased, Cho/Cr increased, and Ino/Cr remained unchanged. No marker peaks or elevated lactate levels were found. The measured metabolic changes were practically independent of the relative plaque size within the volume of interest (8 ml). Thus, the spectral changes measured with 1H MRS in acute Gd-enhancing MS plaques originate not only from the lesion as depicted by MRI, but also from the surrounding normal-appearing white matter.
authors.affiliation: MR Center and Biocenter, University Hospital, University of Basel, Switzerland.
authors.forename: W
authors.initials: W
authors.lastname: Roser
authors.forename: G
authors.initials: G
authors.lastname: Hagberg
authors.forename: I
authors.initials: I
authors.lastname: Mader
authors.forename: H
authors.initials: H
authors.lastname: Brunnschweiler
authors.forename: E W
authors.initials: EW
authors.lastname: Radue
authors.forename: J
authors.initials: J
authors.lastname: Seelig
authors.forename: L
authors.initials: L
authors.lastname: Kappos
mesh_terms: D000328:Adult; D001923:Brain Chemistry; D002794:Choline / Q000032:analysis; D003287:Contrast Media; D003401:Creatine / Q000032:analysis; D005682:Gadolinium; D006571:Heterocyclic Compounds; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000378:metabolism*; D009942:Organometallic Compounds; D010725:Phosphocreatine / Q000032:analysis
chemical_list: D003287:Contrast Media; D006571:Heterocyclic Compounds; D009942:Organometallic Compounds; D010725:Phosphocreatine; C050823:gadolinium 1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetate; D005682:Gadolinium; D003401:Creatine; D002794:Choline