Natural and experimental transfer of anti-Pertussis antibodies confers resistance to experimental autoimmune encephalomyelitis.
Pregnant rats challenged with Bordetela Pertussis vaccine, with or without encephalitogenic antigen during pregnancy, transferred a resistance to induction of experimental autoimmune encephalomyelitis (EAE) to their offspring. Cross-fostering experiments showed that the protection against EAE is conferred during the lactation period through the transfer of anti pertussis antibodies in the milk. The degree of protection correlated with antibody levels. Passive transfer of these antibodies through intraperitoneal injection to naive adult rats also conferred the same degree of protection against EAE induction. It is suggested that such transfer of resistance and antibodies may serve as a model for the study of milk transmitted immunocompetent factors, as well as a model for the mechanisms involved in the resistance to EAE.
Brenner
T
T
Department of Neurology, Hadassah-Hebrew University Hospital, Ein Kerem, Jerusalem, Israel.
Abramsky
O
O
D000375:Aging / Q000276:immunology; D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis / Q000276:immunology*; D000918:Antibody Specificity; D004681:Encephalomyelitis, Autoimmune, Experimental / Q000276:immunology*; D005260:Female; D007112:Immunity, Maternally-Acquired; D007116:Immunization, Passive; D007136:Immunoglobulins / Q000276:immunology; D008892:Milk / Q000276:immunology; D004676:Myelin Basic Protein / Q000276:immunology; D010567:Pertussis Vaccine / Q000276:immunology; D011247:Pregnancy; D051381:Rats; D014917:Whooping Cough / Q000276:immunology*
D000907:Antibodies, Bacterial; D007136:Immunoglobulins; D004676:Myelin Basic Protein; D010567:Pertussis Vaccine