[Carbohydrate deficient transferrin--a reliable marker of alcohol abuse?].
Carbohydrate deficient transferrin (CDT) is an isoform of transferrin with a reduced carbohydrate content, especially the negatively charged sialic acid. This alters the pI value and allows the separation of CDT from normal transferrin. CDT has a higher sensitivity and specificity than other currently known markers of alcoholism. Increased CDT values are found in patients with non-alcoholic liver disease. The cost of the analysis is high and the benefit of this marker is still uncertain.
Bathum
L
L
Odense Universitetshospital, klinisk kemisk afdeling.
D000437:Alcoholism / Q000175:diagnosis* / Q000378:metabolism; D015415:Biomarkers / Q000032:analysis*; D002241:Carbohydrates / Q000032:analysis*; D002845:Chromatography; D006801:Humans; D007525:Isoelectric Focusing; D014168:Transferrin / Q000032:analysis* / Q000737:chemistry
D015415:Biomarkers; D002241:Carbohydrates; D014168:Transferrin
Carbohydratdeficiant transferrin--en plidelig alkoholmarkør?