Requirement of MIP-1 alpha for an inflammatory response to viral infection.
Macrophage inflammatory protein-1 alpha (MIP-1 alpha) is a chemokine that has pro-inflammatory and stem cell inhibitory activities in vitro. Its biologic role in vivo was examined in mice in which the gene encoding MIP-1 alpha had been disrupted. Homozygous MIP-1 alpha mutant (-/-) mice were resistant to Coxsackievirus-induced myocarditis seen in infected wild-type (+/+) mice. Influenza virus-infected -/- mice had reduced pneumonitis and delayed clearance of the virus compared with infected +/+ mice. The -/- mice had no overt hematopoietic abnormalities. These results demonstrate that MIP-1 alpha is an important mediator of virus-induced inflammation in vivo.
Cook
D N
DN
Department of Pathology, University of North Carolina, Chapel Hill 27599-7525, USA.
Beck
M A
MA
Coffman
T M
TM
Kirby
S L
SL
Sheridan
J F
JF
Pragnell
I B
IB
Smithies
O
O
D000818:Animals; D000914:Antibodies, Viral / Q000097:blood; D001402:B-Lymphocytes / Q000276:immunology; D001483:Base Sequence; D054407:Chemokine CCL4; D003384:Coxsackievirus Infections / Q000276:immunology* / Q000821:virology; D016207:Cytokines / Q000235:genetics / Q000502:physiology*; D029822:Enterovirus B, Human / Q000254:growth & development / Q000276:immunology; D018390:Gene Targeting; D006410:Hematopoiesis; D009980:Influenza A virus / Q000254:growth & development / Q000276:immunology; D008213:Lymphocyte Activation; D019402:Macrophage Inflammatory Proteins; D051379:Mice; D008810:Mice, Inbred C57BL; D008969:Molecular Sequence Data; D015846:Monokines / Q000235:genetics / Q000502:physiology*; D009205:Myocarditis / Q000276:immunology* / Q000821:virology; D009500:Neutralization Tests; D009976:Orthomyxoviridae Infections / Q000276:immunology* / Q000821:virology; D013234:Stem Cells; D013601:T-Lymphocytes / Q000276:immunology
D000914:Antibodies, Viral; D054407:Chemokine CCL4; D016207:Cytokines; D019402:Macrophage Inflammatory Proteins; D015846:Monokines