[The efficacy of using thymogen in an experimental infection caused by Yersinia enterocolitica].
The effect of thymogen of the course of the infectious process caused by Y.enterocolitica serovars O3 and O9 in guinea pigs was studied. Thymogen was introduced into the animals on day 2 after their infection with Y.enterocolitica O3 and O9, introduced in daily injections of 10 micrograms/kg of body weight for 4 days. The evaluation of the characteristics of cell reactions in the lymphoid organs of the immune system (the thymus, the spleen, lymph nodes), nonspecific resistance and specific humoral response showed the effectiveness of using thymogen: this preparation produced an immunoregulatory effect in the infected animals; it decreased their polyclonal immune response, the development of autoimmune reactions and promoted the intensive development of delayed hypersensitivity (DH) after their enteral infection with Y.enterocolitica O9 and had no effect on the development of DH in the animals infected with Y.enterocolitica O3; it also enhanced the nonspecific resistance of the body, thus leading to a decrease in the dissemination of the infective agents in different organs and tissues and to their subsequent elimination from the body.
Iushchuk
N D
ND
Tseneva
G Ia
GIa
Alenushkina
T V
TV
Kuliashova
L B
LB
D000276:Adjuvants, Immunologic / Q000627:therapeutic use*; D000818:Animals; D001402:B-Lymphocytes / Q000187:drug effects / Q000276:immunology; D004151:Dipeptides; D004195:Disease Models, Animal; D004353:Drug Evaluation, Preclinical; D006168:Guinea Pigs; D007111:Immunity, Cellular / Q000187:drug effects; D007113:Immunity, Innate / Q000187:drug effects; D010455:Peptides / Q000627:therapeutic use*; D013601:T-Lymphocytes / Q000187:drug effects / Q000276:immunology; D013997:Time Factors; D015009:Yersinia Infections / Q000188:drug therapy* / Q000276:immunology; D015008:Yersinia enterocolitica
D000276:Adjuvants, Immunologic; D004151:Dipeptides; D010455:Peptides; C060736:thymogen
Effektivnost' primeneniia timogena pri éksperimental'noĭ infektsii, vyzvannoĭ Yersinia enterocolitica.