[Functional morphology of the lymph nodes and spleen in atherogenesis].
The composition and functional activity of lymphocytes populating T- and B-zones of human lymph nodes and spleen in atherogenesis were studied. Structural, functional alterations first involved T- and B-zones of the spleen and para-aortal lymph nodes this being probably conditioned by immune response to formation of autoantigenic forms of apoB-containing lipoproteins. Along with the development of atherosclerotic damage to the arteries the immunomorphological restructuration became more generalized and could be observed in the lymph nodes non-regional to the aorta. These changes were obviously connected at a higher degree with the development of sensitization to the vascular wall antigens.
Pigarevskiĭ
P V
PV
Nagornev
V A
VA
D000328:Adult; D000368:Aged; D001161:Arteriosclerosis / Q000276:immunology / Q000473:pathology*; D001324:Autoantigens / Q000096:biosynthesis; D001402:B-Lymphocytes / Q000276:immunology*; D006801:Humans; D008198:Lymph Nodes / Q000276:immunology / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D013154:Spleen / Q000276:immunology / Q000473:pathology*; D013601:T-Lymphocytes / Q000276:immunology*
D001324:Autoantigens
Funktsional'naia morfologiia limfaticheskikh uzlov i selezenki pri aterogeneze.