title: Luteal phase estradiol and pregnancy outcome in gonadotropin releasing hormone agonist/human menopausal gonadotropin-treated gamete intrafallopian transfer cycles.
abstract: To correlate luteal estradiol (E2) levels with pregnancy outcome, 36 consecutive conceptions resulting from gamete intrafallopian transfer in gonadotropin releasing hormone agonist/human menopausal gonadotropin (GnRH-a/hMG) cycles were analyzed. GnRH-a was initiated during the preceding luteal phase. HMG was adjusted individually. Human chorionic gonadotropin (hCG), 5,000 IU, was administered when E2 was > 500 pg/mL and the leading follicle > 17 mm (day 0). The luteal phase was supported by (1) hCG, 1,500 IU in three doses from day 5 and (2) progesterone (P) from day 7. E2 and P levels were analyzed in three groups of patients: normally progressing pregnancy (NPP), abortion (AB) and preclinical abortion (PAB). No significant differences in mean E2 levels were seen between the groups from day 0 through day 5 after hCG. Midluteal E2 levels were significantly different between the groups (P < .05). Late luteal E2 values were significantly higher for NPP than for either AB or PAB (P < .05). There were no significant differences in luteal P values between the NPP, AB and PAB groups. Decreased luteal E2 appears to be associated with early pregnancy wastage; this may be due to inadequate endometrial support.
authors.affiliation: Department of Obstetrics and Gynecology, Rush Medical College, Chicago, Illinois 60612, USA.
authors.forename: M W
authors.initials: MW
authors.lastname: Molo
authors.forename: R G
authors.initials: RG
authors.lastname: Rawlins
authors.forename: Z
authors.initials: Z
authors.lastname: Binor
authors.forename: M
authors.initials: M
authors.lastname: Kelly
authors.forename: E
authors.initials: E
authors.lastname: Radwanska
mesh_terms: D000022:Abortion, Spontaneous; D000328:Adult; D002985:Clinical Protocols; D004958:Estradiol / Q000097:blood*; D005260:Female; D005498:Follicular Phase; D015181:Gamete Intrafallopian Transfer / Q000379:methods*; D007987:Gonadotropin-Releasing Hormone / Q000819:agonists*; D006801:Humans; D008183:Luteal Phase; D008596:Menotropins / Q000627:therapeutic use*; D011247:Pregnancy; D011256:Pregnancy Outcome
chemical_list: D007987:Gonadotropin-Releasing Hormone; D004958:Estradiol; D008596:Menotropins