title: Plasma levels of 8-methoxypsoralen after bath-PUVA for psoriasis: relationship to disease severity.
abstract: Plasma levels of 8-methoxypsoralen (8-MOP) were determined by high-pressure liquid chromatography in 19 patients with psoriasis who were receiving bath-PUVA treatment, at different time points after the psoralen bath. The levels of 8-MOP varied between < 5 ng/ml (lower limit of detection) and 34 ng/ml, and we found a relationship between the plasma psoralen levels and the severity of the disease.
authors.affiliation: Department of Dermatology, Hospital Ramón y Cajal, Madrid, Spain.
authors.forename: M I
authors.initials: MI
authors.lastname: Gómez
authors.forename: J M
authors.initials: JM
authors.lastname: Azaña
authors.forename: I
authors.initials: I
authors.lastname: Arranz
authors.forename: A
authors.initials: A
authors.lastname: Harto
authors.forename: A
authors.initials: A
authors.lastname: Ledo
mesh_terms: D000279:Administration, Cutaneous; D000284:Administration, Oral; D001494:Baths; D018849:Controlled Clinical Trials as Topic; D006801:Humans; D008730:Methoxsalen / Q000008:administration & dosage / Q000097:blood*; D011701:PUVA Therapy; D017319:Photosensitizing Agents / Q000008:administration & dosage / Q000097:blood*; D011565:Psoriasis / Q000097:blood* / Q000188:drug therapy* / Q000473:pathology; D012720:Severity of Illness Index
chemical_list: D017319:Photosensitizing Agents; D008730:Methoxsalen