[Use of dobutrex in critical states in patients with acute poisoning of chemical etiology].
Efficacy of dobutrex was assessed in 75 patients with grave poisonings. In 45 of these poisoning with cardiotoxic agents was complicated by acute heart failure and in 30 poisoning with psychopharmacological agents involved secondary disorders of cardiac contractile function. A sharp reduction of cardiac contractile function and output were observed in all the cases. Treatment efficacy was assessed by monitoring the parameters of central hemodynamics and by phase analysis of left-ventricular systole by rheopolycardiography with recording by mingograf-82. The results indicated a rapid and effective correction of decreased cardiac contractility and increase of cardiac output. The dose-effective concentration of dobutrex in the blood needed for the treatment of acute heart failure was from 10 to 17.5 micrograms/kg/min. Arterial pressure, cardiac contractility, and cardiac output stabilized within 4 to 6 h. After poisoning with psychopharmacological agents cardiac contractility recovered in 3-3.5 h. The dose-effective concentration of dobutrex in the blood was 5 micrograms/kg/min. Dobutrex is a highly active cardiotonic agent for the treatment of critical states developing in the aforesaid poisonings.
Savina
A S
AS
Il'iashenko
K K
KK
D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D001463:Barbiturates / Q000506:poisoning*; D004280:Dobutamine / Q000627:therapeutic use*; D006439:Hemodynamics; D006801:Humans; D008875:Middle Aged; D009200:Myocardial Contraction; D010640:Phenothiazines / Q000506:poisoning*; D011041:Poisoning / Q000188:drug therapy* / Q000503:physiopathology; D011619:Psychotropic Drugs / Q000506:poisoning*; D013997:Time Factors
D001463:Barbiturates; D010640:Phenothiazines; D011619:Psychotropic Drugs; D004280:Dobutamine
Primenenie dobutreksa pri kriticheskikh sostoianiiakh u bol'nykh s ostrymi otravleniiami khimicheskoĭ étiologii.