[Protective effect of the fulvotomentosides on paracetamol-induced hepatotoxicity in mice].
Fulvotomentoside alpha-hederin (H) and sapindoside B (S) are two components of the fulvotomentosides reported to decrease the toxicity of a number of hepatotoxins in mice. We studied the effects of the mixture of alpha-hederin and sapindoside B (HS) on paracetamol (Par)-induced liver injury. HS (20 mg.kg-1 sc twice) was shown to decrease the mortality produced by Par. The liver injury produced by Par was remarkably decreased as indicated by decrease of sGPT and by histopathological examination. Additionally, HS mitigated the hepatic GSH depletion caused by Par. Par excretion into urine was increased following HS.
Shi
J Z
JZ
Guizhou Institute of Traditional Chinese Medicine, Guiyang.
Liu
G T
GT
D000082:Acetaminophen; D000818:Animals; D056486:Chemical and Drug Induced Liver Injury; D004365:Drugs, Chinese Herbal / Q000302:isolation & purification / Q000494:pharmacology*; D005978:Glutathione / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008107:Liver Diseases / Q000378:metabolism / Q000517:prevention & control*; D008297:Male; D051379:Mice; D009828:Oleanolic Acid / Q000031:analogs & derivatives*; D012503:Saponins / Q000302:isolation & purification / Q000494:pharmacology*
D004365:Drugs, Chinese Herbal; D012503:Saponins; C061620:fulvotomentoside A; D000082:Acetaminophen; D009828:Oleanolic Acid; D005978:Glutathione