title: Prenatal lorazepam exposure: 4. Persistent alterations in pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake after prenatal lorazepam exposure.
abstract: Prenatal benzodiazepine exposure is associated with behavioral and neurochemical alterations in the early postnatal period. To determine the persistence of these effects, we evaluated pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake in mice at 6 and 12 months of age after prenatal lorazepam exposure. Seizure threshhold was reduced after acute lorazepam pretreatment in mice exposed to lorazepam prenatally, compared to control groups, at 6 and 12 months of age. Maximal GABA-dependent chloride uptake was also reduced in exposed mice at 6 and 12 months of age. These data indicate that behavioral and neurochemical alterations persist well into maturity after prenatal lorazepam exposure.
authors.affiliation: Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA.
authors.forename: J M
authors.initials: JM
authors.lastname: Koff
authors.forename: L G
authors.initials: LG
authors.lastname: Miller
mesh_terms: D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism*; D002713:Chlorine; D005260:Female; D008140:Lorazepam / Q000494:pharmacology*; D051379:Mice; D009118:Muscimol / Q000494:pharmacology; D010433:Pentylenetetrazole; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011868:Radioisotopes; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
chemical_list: D002712:Chlorides; D011868:Radioisotopes; D009118:Muscimol; D002713:Chlorine; D005680:gamma-Aminobutyric Acid; D008140:Lorazepam; D010433:Pentylenetetrazole