title: Effects of internal mammary artery pedicle coronary artery bypass grafting on aortic valve leaflet positioning.
abstract: Approximately 50% of all patients who require replacement of the aortic valve (AVR) also require coronary artery bypass grafting (CABG) for concomitant coronary artery disease. Internal mammary artery (IMA) pedicle grafts are being used with increasing frequency for this purpose. Since the ostia of the IMA are considerably downstream from the sinus of Valsalva we hypothesized the CABG would change the local coronary flow dynamics and possibly alter the timing of both natural and prosthetic valve opening and closing dynamics. Both IMA'S were dissected as pedicle grafts in five pigs and the animals were put on cardiopulmonary bypass. Anastomotic sites were the proximal 1/3 of the left anterior descending and proximal 1/5 of the right coronary arteries. Aortic root, left ventricular and right ventricular pressures were measured and flowmeter transducers were placed on the aortic root, the left main coronary artery, the right coronary artery, the left IMA and the right IMA for measuring flows. Echocardiographic images of the aortic valve, in the longitudinal view, were recorded with a simultaneous ECG. Time points were defined during each cardiac cycle based upon characteristic points in the native coronary hemodynamics. These were identified at 8, 14 and 22% of the cycle (valve opening) and 38, 45 and 55% of the cycle (valve closing). Calculations were made based upon each cycle being initiated with the ECG R wave peak. Significant alterations in flow patterns were identified and quantitated between native coronary and IMA grafts. Only minor changes in valve positioning were identified. These differences in natural valve leaflet position occurred at 22% and 45% of the cycle.
authors.affiliation: Department of Surgery, University of Kentucky College of Medicine, Lexington 40536-0084, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Gross
authors.forename: R K
authors.initials: RK
authors.lastname: Salley
authors.forename: R H
authors.initials: RH
authors.lastname: Maley
authors.forename: W A
authors.initials: WA
authors.lastname: Arden
authors.forename: P
authors.initials: P
authors.lastname: Nammalwar
mesh_terms: D000818:Animals; D001021:Aortic Valve / Q000502:physiology*; D003326:Coronary Circulation; D004562:Electrocardiography; D006439:Hemodynamics; D007387:Internal Mammary-Coronary Artery Anastomosis / Q000379:methods*; D013552:Swine