title: Successful pregnancy after allogeneic bone marrow transplantation following conditioning with total body irradiation.
abstract: A 23-year-old woman had a normal full-term delivery 78 months after BMT for ALL. Conditioning therapy was Ara C 1.4 g/m2 x 4, CY 60 mg/kg x 2 and TBI 2.5 Gy x 5 at a dose rate of 3.5 cGy/min. Despite GVHD prophylaxis with short-term MTX and CsA, she developed grade I acute GVHD, but showed no evidence of chronic GVHD. Following amenorrhea for 4 years, menstruation recommenced spontaneously. She had a normal pregnancy 6 years after BMT resulting in a healthy infant with simple hypospadias. This and previous reports indicate that normal pregnancy is possible after BMT with TBI in excess of 10 Gy.
authors.affiliation: Department of Haematology/Chemotherapy, Kanagawa Cancer Center, Yokohama, Japan.
authors.forename: A
authors.initials: A
authors.lastname: Maruta
authors.forename: M
authors.initials: M
authors.lastname: Matsuzaki
authors.forename: H
authors.initials: H
authors.lastname: Miyashita
authors.forename: F
authors.initials: F
authors.lastname: Kodama
authors.forename: H
authors.initials: H
authors.lastname: Kato
authors.forename: J
authors.initials: J
authors.lastname: Taguchi
authors.forename: N
authors.initials: N
authors.lastname: Tomita
authors.forename: R
authors.initials: R
authors.lastname: Sakai
authors.forename: S
authors.initials: S
authors.lastname: Fujisawa
authors.forename: T
authors.initials: T
authors.lastname: Okubo
mesh_terms: D000208:Acute Disease; D000328:Adult; D016026:Bone Marrow Transplantation; D005260:Female; D006086:Graft vs Host Disease / Q000175:diagnosis; D006801:Humans; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D011247:Pregnancy; D011829:Radiation Dosage; D014184:Transplantation, Homologous; D014916:Whole-Body Irradiation