[A comparative analysis of the effect of stress on the antiaggressive action of tranquilizers in young and sexually mature animals].
The specific features of the development of an aggressive reaction in outbred male albino rats in the poststress period, as well as the differences in the development of this reaction after administration of phenazepam, medazepam, gidazepam, and buspirone were studied. The aggressive threshold was shown to be considerably higher in young animals. There was an increase in the aggressive threshold just following stress and its subsequent decrease in the two age groups. All the tested benzodiazepine tranquilizers, except gidazepam, were demonstrated to produce a proaggressive action while gidazepam diminished young animals' aggression. Nine days after stress the benzodiazepine tranquilizers showed a reverse action which became antiaggressive, in mature animals in particular. Buspirone had no effect on the rats' aggression in the two age groups.
Molodavkin
G M
GM
Voronina
T A
TA
Ramkhin
E Ia
EIa
D000374:Aggression / Q000187:drug effects*; D000375:Aging / Q000187:drug effects*; D000818:Animals; D014151:Anti-Anxiety Agents / Q000494:pharmacology*; D001569:Benzodiazepines; D004305:Dose-Response Relationship, Drug; D004558:Electric Stimulation; D008297:Male; D051381:Rats; D013312:Stress, Physiological / Q000503:physiopathology*; D013997:Time Factors
D014151:Anti-Anxiety Agents; D001569:Benzodiazepines
Sravnitel'nyĭ analiz vliianiia stressa na antiagressivnoe deĭstvie trankvilizatorov u molodykh i polovozrelykh zhivotnykh.