title: Active cell death: role in hepatocarcinogenesis and subtypes.
abstract: Active cell death, the genetically programmed self-destruction of a cell, is now recognized to be a widespread phenomenon in biology that counterbalances mitosis to preserve tissue homeostasis. It is subject to the control of the growth regulatory networks in tissues. Close examination of the morphology of dying cells in liver and other tissues suggests that there are a number of morphological types of active cell death, ranging from forms dominated by nuclear changes and without signs of autophagy ("classical" apoptosis), e.g., in thymocytes and the liver, to those dominated by autophagic degradation of cytoplasm, e.g., in the mammary gland. The induction of gene expression in these diverse types of cell death is anticipated to be different. Here we review the data regarding the regulation of apoptosis in the liver by liver tumor promoter, transforming growth factor beta-1 and related peptides as well as nutrition. In the course of hepatocarcinogenesis, initiated cells as well as preneoplastic and neoplastic cell populations showed enhanced cell replication, but also enhanced apoptosis. Tumor promoter shift the balance between birth and death by increasing the rate of cell replication and by decreasing the rate of apoptosis. Thereby, liver tumor formation is accelerated. Food restriction exhibits the opposite effect and consequently, provides protection from carcinogenesis.
authors.affiliation: Institut für Tumorbiologie-Krebsforschung, Universität Wien, Austria.
authors.forename: W
authors.initials: W
authors.lastname: Bursch
authors.forename: B
authors.initials: B
authors.lastname: Grasl-Kraupp
authors.forename: A
authors.initials: A
authors.lastname: Ellinger
authors.forename: L
authors.initials: L
authors.lastname: Török
authors.forename: H
authors.initials: H
authors.lastname: Kienzl
authors.forename: L
authors.initials: L
authors.lastname: Müllauer
authors.forename: R
authors.initials: R
authors.lastname: Schulte-Hermann
mesh_terms: D000818:Animals; D017209:Apoptosis; D003043:Cocarcinogenesis; D004032:Diet; D006801:Humans; D008113:Liver Neoplasms / Q000473:pathology*; D008114:Liver Neoplasms, Experimental / Q000139:chemically induced / Q000473:pathology; D016212:Transforming Growth Factor beta / Q000502:physiology
chemical_list: D016212:Transforming Growth Factor beta