Clonal fibroblastic cell lines established from a heavily exposed atomic bomb survivor.
Two clonal fibroblast cell lines with simple chromosome aberrations-one with del(3)(p24) and the other with t(1;16)(q21;q11.2)-were established from a high dose (5.14 Gy) female atomic bomb survivor by serial culture of skin fibroblasts. These two types of clonal cells showed a more extended life span than did the cells with 44 other types of chromosome aberrations and normal cells. In addition to these results, a prominent clonal population was observed in the peripheral blood cells in this subject. It is assumed that these clonal populations arose in vivo as a result of radiation exposure to the atomic bomb.
Honda
T
T
Department of Radiobiology, Radiation Effects Research Foundation, Nagasaki Japan.
Sadamori
N
N
Itoh
M
M
Kusumi
O
O
D000368:Aged; D017209:Apoptosis / Q000528:radiation effects*; D002455:Cell Division / Q000528:radiation effects; D002460:Cell Line; D002869:Chromosome Aberrations; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002878:Chromosomes, Human, Pair 1; D002885:Chromosomes, Human, Pair 16; D002893:Chromosomes, Human, Pair 3; D002999:Clone Cells; D004307:Dose-Response Relationship, Radiation; D005260:Female; D005347:Fibroblasts / Q000528:radiation effects*; D006801:Humans; D007564:Japan; D007621:Karyotyping; D008214:Lymphocytes / Q000528:radiation effects; D009689:Nuclear Warfare; D012867:Skin / Q000166:cytology; D014178:Translocation, Genetic