title: [Correlation of cotinine level in amniotic fluid, umbilical artery blood and maternal blood].
abstract: The aim of the present study was to determine the correlation of cotinine levels in amniotic fluid and in fetal and corresponding maternal blood samples. Amniotic fluid samples (N = 130) were taken during second trimester amniocentesis, umbilical artery blood samples (N = 75) at birth, both together with corresponding maternal blood samples. Self-reported smokers showed maternal serum cotinine levels > 15 ng/ml in 93%, self-reported nonsmokers levels < 15 ng/ml in 89%. Correlation of corresponding values for cotinine was 0.81-0.92. Cotinine values were increased in fetal blood and amniotic fluid in comparison to maternal serum levels. Despite the fact that pathophysiology is not fully understood, an accumulation of nicotine and its metabolites both in the fetus and in the amniotic fluid appears to be evident.
authors.affiliation: Medizinische Universität zu Lübeck.
authors.forename: W
authors.initials: W
authors.lastname: Rühle
authors.forename: C L
authors.initials: CL
authors.lastname: Graf von Ballestrem
authors.forename: H M
authors.initials: HM
authors.lastname: Pult
authors.forename: J
authors.initials: J
authors.lastname: Gnirs
mesh_terms: D000649:Amniocentesis; D000653:Amniotic Fluid / Q000378:metabolism*; D003367:Cotinine / Q000493:pharmacokinetics*; D005260:Female; D005312:Fetal Blood / Q000378:metabolism*; D006801:Humans; D007231:Infant, Newborn; D008431:Maternal-Fetal Exchange / Q000502:physiology*; D009538:Nicotine / Q000009:adverse effects / Q000493:pharmacokinetics; D011247:Pregnancy; D011262:Pregnancy Trimester, Second; D012907:Smoking / Q000009:adverse effects / Q000097:blood*; D014028:Tobacco Smoke Pollution / Q000009:adverse effects
chemical_list: D014028:Tobacco Smoke Pollution; D009538:Nicotine; D003367:Cotinine
vernacular_title: Korrelation des Cotininspiegels in Fruchtwasser, Nabelarterienblut und mütterlichem Blut.