Comparative testicular toxicities of two isomers of dichloropropanol, 2,3-dichloro-1-propanol, and 1,3-dichloro-2-propanol, and their metabolites alpha-chlorohydrin and epichlorohydrin, and the potent testicular toxicant 1,2-dibromo-3-chloropropane.
Omura
M
M
Department of Hygiene, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
Hirata
M
M
Zhao
M
M
Tanaka
A
A
Inoue
N
N
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D002728:Chlorohydrins / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D004811:Epichlorohydrin / Q000008:administration & dosage / Q000633:toxicity; D004822:Epididymis / Q000187:drug effects; D007279:Injections, Subcutaneous; D007306:Insecticides / Q000633:toxicity*; D008297:Male; D009153:Mutagens / Q000008:administration & dosage / Q000633:toxicity*; D016273:Occupational Exposure; D009929:Organ Size / Q000187:drug effects; D011407:Propane / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000633:toxicity; D051381:Rats; D017208:Rats, Wistar; D012098:Reproduction / Q000187:drug effects; D012671:Seminiferous Tubules / Q000187:drug effects / Q000473:pathology; D013076:Sperm Count / Q000187:drug effects; D013087:Spermatids / Q000473:pathology; D013094:Spermatozoa / Q000187:drug effects; D013737:Testis / Q000187:drug effects* / Q000378:metabolism; D000517:alpha-Chlorohydrin / Q000008:administration & dosage / Q000031:analogs & derivatives / Q000378:metabolism / Q000633:toxicity
D002728:Chlorohydrins; D007306:Insecticides; D009153:Mutagens; D004811:Epichlorohydrin; C033489:1,3-dichloro-2-propanol; C076159:2,3-dichloro-1-propanol; D000517:alpha-Chlorohydrin; C007318:1,2-dibromo-3-chloropropane; D011407:Propane