Factor VII coagulant activity in relation to serum lipoproteins and dietary fat in middle-aged men.
The associations of serum lipoproteins and habitual diet to factor VII coagulant activity (FVIIc) were analysed in 119 middle-aged men. FVIIc was measured by one-stage clotting assay, cholesterol and triglycerides enzymatically, serum apolipoproteins (apo) immunoturbidimetrically and habitual diet using four-day food records. ApoB, cholesterol, triglycerides, apoA-II, LDL cholesterol and dietary fat correlated directly to FVIIc (p < 0.001). In multivariate analysis apoB, dietary fat and apoA-II explained 35.3% of the variance in FVIIc. In the lowest apoB tertile FVIIc was increased only when fat intake was high (> 38 E%), in the middle tertile FVIIc increased gradually from low to high fat intake, whereas in the highest apoB tertile FVIIc was not related to dietary fat (p = 0.038 for age-adjusted interaction). The present data demonstrate a direct relation between apoB and FVIIc in middle-aged men. Low fat diet seem to associate to decreased FVIIc especially in subjects in the lower end of the apoB distribution.
Väisänen
S
S
Kuopio Research Institute of Exercise Medicine, Finland.
Rankinen
T
T
Penttilä
I
I
Rauramaa
R
R
D000941:Antigens / Q000032:analysis*; D016633:Apolipoprotein A-II / Q000097:blood; D001055:Apolipoproteins B / Q000097:blood; D015992:Body Mass Index; D002318:Cardiovascular Diseases / Q000097:blood / Q000453:epidemiology; D002784:Cholesterol / Q000097:blood; D015331:Cohort Studies; D004041:Dietary Fats; D005167:Factor VII / Q000032:analysis*; D005247:Feeding Behavior; D005387:Finland / Q000453:epidemiology; D006801:Humans; D008074:Lipoproteins / Q000097:blood*; D008297:Male; D008875:Middle Aged; D015999:Multivariate Analysis; D012307:Risk Factors; D012907:Smoking / Q000097:blood; D014280:Triglycerides / Q000097:blood
D000941:Antigens; D016633:Apolipoprotein A-II; D001055:Apolipoproteins B; D004041:Dietary Fats; D008074:Lipoproteins; D014280:Triglycerides; C042580:factor VII clotting antigen; D005167:Factor VII; D002784:Cholesterol