Regulation of motility and invasion of cancer cells by human monocytic cells.
Tumour tissues are frequently seen with monocyte/macrophage infiltration. This study was to establish the role of monocytes on the motile and invasive behaviour of human cancer cells. By using a co-culture technique, we have shown that both human peripheral blood monocytes and a monocytic cell line, U937, stimulated colon and breast cancer cell colony scattering, motility, and invasion into a basement membrane (Matrigel). This effect was enhanced when monocytic cells were stimulated by a particulate stimulus. IL-4 and IL-10 reduced these effects of monocytes. We conclude that monocytic cells enhance the motility and invasion of tumour cells. These effects can be regulated by inhibitory cytokines of monocytes.
Jiang
W G
WG
University Department of Surgery, University of Wales College of Medicine, Cardiff, UK.
Hiscox
S
S
Hallett
M B
MB
Mansel
R E
RE
Puntis
M C
MC
D002455:Cell Division; D002465:Cell Movement; D006801:Humans; D016753:Interleukin-10 / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology; D009000:Monocytes / Q000502:physiology*; D009361:Neoplasm Invasiveness; D014407:Tumor Cells, Cultured
D016753:Interleukin-10; D015847:Interleukin-4