Traumatic dysesthesia of the trigeminal nerve.
Traumatic injury to the peripheral nerves often results in persistent discomfort. Substance P has been implicated as a mediator of pain, and depletion of this neurotransmitter has been shown to reduce pain. Subjects suffering from traumatic dysesthesia of the trigeminal nerve were treated with capsaicin, a substance P depleter with significant long-term effects. This form of therapy may be used individually or in combination with other pharmacologic interventions in the treatment of traumatic trigeminal dysesthesia.
Canavan
D
D
Department of Orofacial Pain, School of Dentistry, University of California, Los Angeles 90024, USA.
Graff-Radford
S B
SB
Gratt
B M
BM
D000287:Administration, Topical; D000368:Aged; D000929:Antidepressive Agents, Tricyclic / Q000627:therapeutic use*; D002211:Capsaicin / Q000008:administration & dosage / Q000627:therapeutic use*; D003891:Desipramine / Q000627:therapeutic use; D004359:Drug Therapy, Combination; D005157:Facial Pain / Q000188:drug therapy* / Q000209:etiology; D005260:Female; D006801:Humans; D007509:Irritants / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D008334:Mandible / Q000601:surgery; D008337:Mandibular Fractures / Q000150:complications; D009661:Nortriptyline / Q000627:therapeutic use; D010292:Paresthesia / Q000188:drug therapy / Q000209:etiology; D011183:Postoperative Complications / Q000188:drug therapy*; D015361:Rhytidoplasty / Q000009:adverse effects; D061221:Trigeminal Nerve Injuries; D014277:Trigeminal Neuralgia / Q000188:drug therapy* / Q000209:etiology
D000929:Antidepressive Agents, Tricyclic; D007509:Irritants; D009661:Nortriptyline; D002211:Capsaicin; D003891:Desipramine