title: Regulation of motility and invasion of cancer cells by human monocytic cells.
abstract: Tumour tissues are frequently seen with monocyte/macrophage infiltration. This study was to establish the role of monocytes on the motile and invasive behaviour of human cancer cells. By using a co-culture technique, we have shown that both human peripheral blood monocytes and a monocytic cell line, U937, stimulated colon and breast cancer cell colony scattering, motility, and invasion into a basement membrane (Matrigel). This effect was enhanced when monocytic cells were stimulated by a particulate stimulus. IL-4 and IL-10 reduced these effects of monocytes. We conclude that monocytic cells enhance the motility and invasion of tumour cells. These effects can be regulated by inhibitory cytokines of monocytes.
authors.affiliation: University Department of Surgery, University of Wales College of Medicine, Cardiff, UK.
authors.forename: W G
authors.initials: WG
authors.lastname: Jiang
authors.forename: S
authors.initials: S
authors.lastname: Hiscox
authors.forename: M B
authors.initials: MB
authors.lastname: Hallett
authors.forename: R E
authors.initials: RE
authors.lastname: Mansel
authors.forename: M C
authors.initials: MC
authors.lastname: Puntis
mesh_terms: D002455:Cell Division; D002465:Cell Movement; D006801:Humans; D016753:Interleukin-10 / Q000494:pharmacology; D015847:Interleukin-4 / Q000494:pharmacology; D009000:Monocytes / Q000502:physiology*; D009361:Neoplasm Invasiveness; D014407:Tumor Cells, Cultured
chemical_list: D016753:Interleukin-10; D015847:Interleukin-4