Antidiabetic and hypolipidemic effects of S-methyl cysteine sulfoxide isolated from Allium cepa Linn.
S-methyl cysteine sulphoxide (SMCS), a sulphur containing amino acid isolated from onion (Allium cepa Linn) showed antidiabetic and antihyperlipidemic effects. Oral administration of SMCS daily at a dose of 200 mg/kg body weight for a period of 45 days to alloxan diabetic rats controlled significantly their blood glucose and lipids in serum and tissues and altered the activities of liver hexokinase, glucose 6-phosphatase and HMG CoA reductase towards normal. The above effects of SMCS were comparable to those of glibenclamide and insulin.
Kumari
K
K
Department of Biochemistry, University of Kerala, Trivandrum.
Mathew
B C
BC
Augusti
K T
KT
D000490:Allium / Q000737:chemistry*; D000818:Animals; D003545:Cysteine / Q000031:analogs & derivatives* / Q000302:isolation & purification / Q000494:pharmacology; D003921:Diabetes Mellitus, Experimental / Q000188:drug therapy*; D007004:Hypoglycemic Agents / Q000494:pharmacology*; D000960:Hypolipidemic Agents / Q000494:pharmacology*; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley
D007004:Hypoglycemic Agents; D000960:Hypolipidemic Agents; C008389:methiin; D003545:Cysteine