A discriminant function analysis of various interferon parameters among alcoholics and heavy smokers.
A three-group design of alcoholics, heavy smokers and controls was used to investigate the status of the interferon system, including natural killer cell activity. Group differences were indicated via discriminant function analysis which correctly classified 86% of subjects. Test-retest relations were investigated for 14 subjects following a 30-day alcoholic inpatient program. Whereas significant immune suppression was indicated at the time of detoxification, recovery was evident at the 30-day follow-up. Results are discussed in terms of the significance of alcohol abuse on immune system functioning with consequences for susceptibility to viruses, bacteria and medical illnesses.
Windle
M
M
Research Institute on Alcoholism, Buffalo, NY 14203.
Mondul
T
T
Whitney
R B
RB
Cummings
K M
KM
Stadler
I
I
Chadha
K C
KC
D000328:Adult; D000437:Alcoholism / Q000276:immunology* / Q000534:rehabilitation; D006801:Humans; D007108:Immune Tolerance / Q000276:immunology; D007372:Interferons / Q000037:antagonists & inhibitors / Q000097:blood*; D007694:Killer Cells, Natural / Q000187:drug effects / Q000276:immunology; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D012907:Smoking / Q000276:immunology*; D016540:Smoking Cessation
D007372:Interferons