[Genetic aspects of BCG vaccination in experimental tuberculosis].
The paper discusses the genetic control of and the mechanisms of protective antituberculous immunity following BCG vaccination in inbred mice. The following genetic systems H-2 (B10.M)(H-2f) and B10.SM (H-2v) congenics were not protected with a high dose of BCG vaccine); Xid (X-linked immunodeficiency) CBA/N mice were not protected with regularly protective doses of BCG vaccine; Tbc-1 (I/St mice (Tbc-1s) were hypersensitive to tuberculosis. In two genetic systems (H-2 and xid), a distinct genetic control of susceptibility to primary tuberculosis and efficacy of BCG vaccination was demonstrated.
Nikonenko
B V
BV
Apt
A S
AS
Mezhlumova
M V
MV
Pospelov
L E
LE
Moroz
A M
AM
D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage; D004198:Disease Susceptibility; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D014376:Tuberculosis / Q000235:genetics* / Q000276:immunology / Q000517:prevention & control; D014611:Vaccination
D001500:BCG Vaccine
Geneticheskie aspekty vaktsinatsii BCG pri éksperimental'nom tuberkuleze.