title: Correlation between serotonergic measures in cerebrospinal fluid and blood of subhuman primate.
abstract: The relationship between the concentration of serotonin (5-hydroxytryptamine; 5-HT), its precursor; tryptophan (Trp) and the main metabolite 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF) and blood of monkey have been studied. 5-HT, Trp and 5-HIAA underwent circadian changes in both CSF and blood. Significant correlations were found between 5-HT, 5-HIAA and Trp in CSF and blood. The significance of these findings and their relationship to the use of peripheral serotonergic system as a functional model of the central nervous system are discussed.
authors.affiliation: Department of Physiology, Hamamatsu University School of Medicine, Handa-cho, Japan.
authors.forename: D
authors.initials: D
authors.lastname: Yan
authors.forename: T
authors.initials: T
authors.lastname: Urano
authors.forename: M H
authors.initials: MH
authors.lastname: Pietraszek
authors.forename: I
authors.initials: I
authors.lastname: Shimoyama
authors.forename: K
authors.initials: K
authors.lastname: Uemura
authors.forename: Y
authors.initials: Y
authors.lastname: Kojima
authors.forename: K
authors.initials: K
authors.lastname: Sakakibara
authors.forename: K
authors.initials: K
authors.lastname: Serizawa
authors.forename: Y
authors.initials: Y
authors.lastname: Takada
authors.forename: A
authors.initials: A
authors.lastname: Takada
mesh_terms: D000818:Animals; D002940:Circadian Rhythm; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D008251:Macaca; D008297:Male; D012701:Serotonin / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D014364:Tryptophan / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid
chemical_list: D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan