The in vivo regulation of hepatic and renal glucose-6-phosphatase by thyroxine.
The hepatic and renal microsomal glucose-6-phosphatase enzymes are situated with their active site in the lumen of the endoplasmic reticulum and for normal enzyme activity in vivo transport systems are needed for the substrates and products of the enzyme. We have shown that thyroxine activates the kidney glucose-6-phosphatase enzyme and the liver glucose 6-phosphate transport systems. In contrast, in hypophysectomised and adrenalectomised animals, thyroxine activates the transport systems and the enzyme in both liver and kidney.
Voice
M W
MW
Department of Obstetrics and Gynaecology, University of Dundee, Ninewells Hospital and Medical School, UK.
Borthwick
E B
EB
Coughtrie
M W
MW
Burchell
A
A
D000315:Adrenalectomy; D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D004721:Endoplasmic Reticulum / Q000201:enzymology; D004789:Enzyme Activation / Q000187:drug effects; D005260:Female; D005952:Glucose-6-Phosphatase / Q000378:metabolism*; D006003:Glycogen / Q000032:analysis; D007016:Hypophysectomy; D007668:Kidney / Q000201:enzymology*; D008099:Liver / Q000201:enzymology*; D008297:Male; D008862:Microsomes, Liver / Q000201:enzymology; D051381:Rats; D017208:Rats, Wistar; D013974:Thyroxine / Q000494:pharmacology*
D001786:Blood Glucose; D006003:Glycogen; D005952:Glucose-6-Phosphatase; D013974:Thyroxine