In vitro susceptibility to itraconazole and fluconazole of switch phenotypes of Candida albicans serotypes A and B, isolated from immunocompromised hosts.
Data from 78 oropharyngeal samples obtained from severely immunocompromised individuals, have shown that the B serotype and the stipple phenotype of Candida albicans isolates have significantly higher minimum inhibitory concentration values towards itraconazole and fluconazole, as compared with the corresponding serotype A phenotype (P < 0.05). The epidemiological significance of the phenotype-dependent drug susceptibility patterns is discussed.
Velegraki
A
A
Department of Microbiology, Medical School, University of Athens, Greece.
D002176:Candida albicans / Q000145:classification / Q000187:drug effects*; D015725:Fluconazole / Q000494:pharmacology*; D006801:Humans; D016867:Immunocompromised Host; D017964:Itraconazole / Q000494:pharmacology*; D008826:Microbial Sensitivity Tests; D016533:Mycological Typing Techniques; D009960:Oropharynx / Q000382:microbiology; D010641:Phenotype
D017964:Itraconazole; D015725:Fluconazole