title: Bullous pemphigoid successfully controlled by tetracycline and nicotinamide.
abstract: In 1986, Berk and Lorincz reported the efficacy of tetracycline and nicotinamide in the treatment of bullous pemphigoid (BP). In the present study of seven patients with BP, we found that a regimen of 2 g tetracycline combined with 2 g nicotinamide daily was effective in clearing the skin lesions. Total remission was achieved within 6-8 weeks, after which the dose was gradually tapered. The mean duration of therapy was 7 months. No effect on the titre of antibasement membrane antibodies was observed. The mode of action of this therapy is unknown.
authors.affiliation: Department of Dermatology, Academisch Ziekenhuis, Groningen, Velsen, The Netherlands.
authors.forename: D N
authors.initials: DN
authors.lastname: Kolbach
authors.forename: J J
authors.initials: JJ
authors.lastname: Remme
authors.forename: W H
authors.initials: WH
authors.lastname: Bos
authors.forename: M F
authors.initials: MF
authors.lastname: Jonkman
authors.forename: M C
authors.initials: MC
authors.lastname: De Jong
authors.forename: H H
authors.initials: HH
authors.lastname: Pas
authors.forename: J B
authors.initials: JB
authors.lastname: van der Meer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000627:therapeutic use*; D010391:Pemphigoid, Bullous / Q000188:drug therapy*; D013752:Tetracycline / Q000627:therapeutic use*; D016896:Treatment Outcome
chemical_list: D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D009536:Niacinamide; D013752:Tetracycline