Studies on the inhibition of rejection of Trichostrongylus colubriformis larvae from immune sheep.
A total of 8 drugs were examined for their ability to suppress the rejection of Trichostrongylus colubriformis infective larvae (L3) from immune sheep. Specific antagonists of leukotrienes (piroxicam), prostaglandin (indomethacin) and the immunosuppressant cyclosporin A were given orally, while injectable preparations of dexamethasone, chlorpheniramine, BN 52051, WEB 2086 (anti-platelet-activating factor) and theophylline were administered as directed. The drugs were given for 5 days prior to and 4 days after challenge with 20,000 L3, when worm counts were done. Corticosteroids inhibited rejection by around 70% in two experiments, and none of the remaining compounds were effective. In the third study, six of the drugs were given to susceptible sheep and did not affect the establishment of a primary infection with T. colubriformis.
Emery
D L
DL
CSIRO Division of Animal Health, McMaster Laboratory, Glebe, Australia.
McClure
S J
SJ
D000818:Animals; D001381:Azepines / Q000494:pharmacology; D002744:Chlorpheniramine / Q000494:pharmacology; D016572:Cyclosporine / Q000494:pharmacology; D003907:Dexamethasone / Q000494:pharmacology; D007213:Indomethacin / Q000494:pharmacology; D007814:Larva / Q000276:immunology; D010894:Piroxicam / Q000494:pharmacology; D012059:Rejection, Psychology; D012756:Sheep; D012757:Sheep Diseases / Q000276:immunology* / Q000469:parasitology; D013806:Theophylline / Q000494:pharmacology; D014230:Triazoles / Q000494:pharmacology; D014253:Trichostrongylosis / Q000276:immunology / Q000469:parasitology / Q000662:veterinary*; D014254:Trichostrongylus / Q000276:immunology*
D001381:Azepines; D014230:Triazoles; C052518:WEB 2086; D010894:Piroxicam; D002744:Chlorpheniramine; D003907:Dexamethasone; D016572:Cyclosporine; D013806:Theophylline; D007213:Indomethacin