A new cytogenetic subgroup in uterine leiomyoma is characterized by a deletion of the long arm of chromosome 3.
Our cytogenetic findings in 175 uterine leiomyomas revealed 52 tumors with clonal chromosome abnormalities, eight of which did not belong to any well-delineated cytogenetic abnormal subgroup. However, an interstitial deletion of the long arm of chromosome 3 was found, as the sole chromosome abnormality, in three cases. We believe that this involvement of 3q is significant enough to consider it as a new cytogenetic subgroup of uterine leiomyoma.
Dal Cin
P
P
Center for Human Genetics, University of Leuven, Belgium.
Moerman
P
P
Deprest
J
J
Brosens
I
I
Van den Berghe
H
H
D000328:Adult; D002893:Chromosomes, Human, Pair 3; D005260:Female; D017353:Gene Deletion; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000235:genetics*