title: Evaluation of tissue adhesives in closure of scleral tunnel incisions.
abstract: Using a biomechanical wound strength model, we compared the efficacy of cyanoacrylate and fibrin glues used to close scleral tunnel incisions. Scleral tunnel incisions were made in four groups of rabbits: (1) traditional self-sealing incision, (2) modified non-self-sealing incision, (3) method 2, closed with cyanoacrylate glue, or (4) method 2, closed with fibrin glue. Overall, Groups 1 and 4 showed the least clinical reaction, the slightest decrease in intraocular pressure (which recovered to baseline by day 7), and the most significant recovery of postoperative astigmatism. Initially, the bursting pressure in Groups 1 and 3 was statistically the highest (P < .005). By day 3, wound strengths in Groups 1 and 4 were comparable. Bursting pressure decreased in Groups 2 and 3 by day 7. Our results indicate that clinical responses, intraocular pressure, induced astigmatism, and ultimately wound strength were comparable in fibrin-glue-closed scleral pocket and sutureless self-sealing cataract incisions. Although cyanoacrylate glue cures immediately and initially demonstrates a strong adhesive quality, it causes a severe inflammatory response that inhibits subsequent collagen remodeling. Fibrin tissue adhesives may have an application as adjunctive means of closing scleral tunnel incisions.
authors.affiliation: Cornea Research Laboratory, University of Rochester, New York, USA.
authors.forename: J C
authors.initials: JC
authors.lastname: Kim
authors.forename: S D
authors.initials: SD
authors.lastname: Bassage
authors.forename: M H
authors.initials: MH
authors.lastname: Kempski
authors.forename: M
authors.initials: M
authors.lastname: del Cerro
authors.forename: S B
authors.initials: SB
authors.lastname: Park
authors.forename: J V
authors.initials: JV
authors.lastname: Aquavella
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001251:Astigmatism / Q000503:physiopathology; D002387:Cataract Extraction; D003487:Cyanoacrylates / Q000008:administration & dosage / Q000592:standards*; D005069:Evaluation Studies as Topic; D015718:Fibrin Tissue Adhesive / Q000008:administration & dosage / Q000592:standards*; D007429:Intraocular Pressure / Q000502:physiology; D007910:Lenses, Intraocular; D011817:Rabbits; D011897:Random Allocation; D012590:Sclera / Q000473:pathology / Q000601:surgery*; D013524:Surgical Flaps; D013529:Surgical Wound Dehiscence / Q000503:physiopathology; D013536:Suture Techniques; D014945:Wound Healing / Q000502:physiology*
chemical_list: D003487:Cyanoacrylates; D015718:Fibrin Tissue Adhesive