title: Pancreatic insulin-secreting carcinoma in a dog: fructosamine for determining persistent hypoglycaemia.
abstract: A five-year-old intact male rottweiler was presented with a history of episodic weakness and mild-generalised seizures. A tentative diagnosis of an insulin-secreting tumour in the pancreas was made based on fasting hypoglycaemia with concomitant hyperinsulinaemia and a subnormal fructosamine value. The diagnosis was confirmed by exploratory coeliotomy, intravenous infusion of methylene blue, histopathology and immuno-histochemical analysis of suspected neoplastic tissue. Fructosamine assays are traditionally used for monitoring the metabolic status of diabetics where a single elevated measurement reflects persistent hyperglycaemia. This report suggests that a single low measurement of fructosamine may indicate persistent hypoglycaemia and may be helpful, in conjunction with an insulin measurement, in the diagnosis of insulin-secreting tumours.
authors.affiliation: Norwegian College of Veterinary Medicine, Department of Small Animal Clinical Sciences, Oslo.
authors.forename: S I
authors.initials: SI
authors.lastname: Thoresen
authors.forename: M
authors.initials: M
authors.lastname: Aleksandersen
authors.forename: L
authors.initials: L
authors.lastname: Lønaas
authors.forename: W P
authors.initials: WP
authors.lastname: Bredal
authors.forename: J
authors.initials: J
authors.lastname: Grøndalen
authors.forename: K
authors.initials: K
authors.lastname: Berthelsen
mesh_terms: D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D004285:Dogs; D019270:Fructosamine; D006595:Hexosamines / Q000378:metabolism*; D007003:Hypoglycemia / Q000175:diagnosis / Q000662:veterinary*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery / Q000662:veterinary*; D011182:Postoperative Care / Q000662:veterinary; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D006595:Hexosamines; D007328:Insulin; D019270:Fructosamine