Incorporation and release of fluorescein isothiocyanate-linked dextrans from a bead-formed macroporous hydrophilic matrix with potential for sustained release.
Freeze-thaw polymerization has been used to generate a bead-formed (100-3000 microns) macroporous hydrophilic matrix with potential for the sustained release of macromolecules. While the incorporation of FITC-dextrans marginally increased the equilibrium water content, their in vitro release profiles were characterized by an initial burst followed by a low but sustained release lasting > 21 d. The total cumulative release of FD-150 and the percentage of the incorporated FD-150 load subsequently released were reduced compared with FD-20S but for both dextrans these parameters could be enhanced by increasing the bead size and increasing the incubation temperature to 37 degrees C.
Atkins
T W
TW
Pharmaceutical Sciences Institute, Aston University, Birmingham, UK.
McCallion
R L
RL
Tighe
B J
BJ
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D003911:Dextrans; D016650:Fluorescein-5-isothiocyanate / Q000031:analogs & derivatives; D008863:Microspheres; D008970:Molecular Weight; D010316:Particle Size; D011102:Polyhydroxyethyl Methacrylate / Q000737:chemistry; D014867:Water
D001672:Biocompatible Materials; D003692:Delayed-Action Preparations; D003911:Dextrans; C015219:fluorescein isothiocyanate dextran; D014867:Water; D011102:Polyhydroxyethyl Methacrylate; D016650:Fluorescein-5-isothiocyanate