title: [Effects of interferon-beta on repair of the retinal pigment epithelium after laser photocoagulation].
abstract: We studied the morphological effects of human interferon-beta on repair of the retinal pigment epithelium (RPE) after moderate dye laser photocoagulation in monkey eyes. In the control eyes, RPE cells were proliferating towards the center from the margin of the laser burn 3 days after photocoagulation. At day 14 after photocoagulation, a newly formed monolayer of RPE cells covered Burch's membrane to repair the lesion. In the eyes treated with interferon-beta by systemic administration, RPE cells had proliferated remarkably 3 days after photocoagulation. The RPE cells proliferated to form multiple layers on Burch's membrane even at day 14 after photocoagulation. These results suggest that interferon-beta promotes the proliferation to repair damaged RPE.
authors.affiliation: Department of Ophthalmology, Kansai Medical University, Osaka-fu, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Tobe
authors.forename: K
authors.initials: K
authors.lastname: Takahashi
authors.forename: N
authors.initials: N
authors.lastname: Kishimoto
authors.forename: H
authors.initials: H
authors.lastname: Ohkuma
authors.forename: M
authors.initials: M
authors.lastname: Uyama
mesh_terms: D000818:Animals; D002455:Cell Division; D016899:Interferon-beta / Q000494:pharmacology*; D017075:Laser Coagulation / Q000009:adverse effects*; D008252:Macaca fascicularis; D008854:Microscopy, Electron; D010857:Pigment Epithelium of Eye / Q000293:injuries / Q000648:ultrastructure*; D014945:Wound Healing
chemical_list: D016899:Interferon-beta