Reduction of adhesion reformation after laparoscopic endometriosis surgery: a randomized trial with an oxidized regenerated cellulose absorbable barrier.
OBJECTIVE
To evaluate the effectiveness of an oxidized regenerated cellulose absorbable barrier (Interceed [TC7] Absorbable Adhesion Barrier) in the reduction of adhesion reformation after laparoscopic surgery for endometriosis.


METHODS
Thirty-two premenopausal nonpregnant women who had severe endometriosis and complete posterior cul-de-sac obliteration and were undergoing laparoscopic surgery were randomly assigned to either surgery alone or surgery and Interceed. None of the subjects received any other treatment for adhesion prevention. Second-look laparoscopy was performed 12-14 weeks after laparoscopic surgery by an investigator blinded to the treatment, and the incidence of adhesion-free subjects was assessed.


RESULTS
Twelve of 16 (75%) women treated with the oxidized regenerated cellulose barrier were free of adhesions, compared with two of 16 (12.5%) controls, a statistically significant difference (P < .05).


CONCLUSIONS
The oxidized regenerated cellulose absorbable barrier significantly reduces adhesion reformation after laparoscopic surgery for endometriosis.
Mais
V
V
Department of Obstetrics and Gynecology, University of Cagliari, Italy.
Ajossa
S
S
Marongiu
D
D
Peiretti
R F
RF
Guerriero
S
S
Melis
G B
GB
D000328:Adult; D002483:Cellulose, Oxidized / Q000627:therapeutic use*; D004715:Endometriosis / Q000601:surgery*; D005260:Female; D005831:Genital Diseases, Female / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D012008:Recurrence; D012086:Reoperation; D016037:Single-Blind Method; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control
D002483:Cellulose, Oxidized; C060002:INTERCEED