title: Relative concentrations of proton MR visible neurochemicals in gray and white matter in human brain.
abstract: The relative distributions of N-acetylaspartate (NAA) + N-acetylaspartylglutamate (NAAG), creatine + phosphocreatine (Cr/PCr), and choline (Cho) in the gray and white matter of human brain were determined by utilizing proton magnetic resonance spectroscopic imaging (SI). The SI data was processed using an automated spectroscopic image processing algorithm, and image segmentation was performed using a supervised technique. Linear regression analysis indicated that the NAA + NAAG (2.01 ppm) and Cr/PCr (3.02 ppm) peaks are greater in gray matter compared with white matter. The large intersubject variation observed in the Cho (3.20 ppm) resonance prevented the assessment of its regional distribution with confidence.
authors.affiliation: Department of Radiology, University of Texas Medical School at Houston 77030, USA.
authors.forename: T J
authors.initials: TJ
authors.lastname: Doyle
authors.forename: B J
authors.initials: BJ
authors.lastname: Bedell
authors.forename: P A
authors.initials: PA
authors.lastname: Narayana
mesh_terms: D000328:Adult; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001923:Brain Chemistry; D002794:Choline / Q000032:analysis; D003401:Creatine / Q000032:analysis; D004151:Dipeptides / Q000032:analysis; D005260:Female; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D009479:Neuropeptides / Q000032:analysis; D010725:Phosphocreatine / Q000032:analysis
chemical_list: D004151:Dipeptides; D009479:Neuropeptides; D010725:Phosphocreatine; C027172:isospaglumic acid; D001224:Aspartic Acid; C000179:N-acetylaspartate; D003401:Creatine; D002794:Choline