[Protective effects of bepridil in combination with anisodamine on myocardial ischemia and reperfusion injury in rats].
The effects of bepridil (Bep) in combination with anisodamine (Ani) on myocardial ischemia and reperfusion injury induced by ligating the left coronary artery were studied in rats. Administration of a combination of Bep and Ani was found to decrease the incidence of arrhythmia induced by myocardial ischemia and reperfusion, increase the myocardial superoxide dismutase (SOD) activities and reduce the myocardial ultrastructural injury in rats. The effect of combination of Bep and Ani was shown to be better than either Bep or Ani alone.
Gu
S L
SL
Department of Pharmacology, Xuzhou Medical College.
Chen
J M
JM
Cui
J Y
JY
Peng
Z Y
ZY
Dong
H Y
HY
Zhou
J
J
D000818:Animals; D000889:Anti-Arrhythmia Agents / Q000008:administration & dosage*; D001145:Arrhythmias, Cardiac / Q000209:etiology / Q000517:prevention & control; D015764:Bepridil / Q000008:administration & dosage*; D004359:Drug Therapy, Combination; D008297:Male; D015428:Myocardial Reperfusion Injury / Q000517:prevention & control*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012991:Solanaceous Alkaloids / Q000008:administration & dosage*
D000889:Anti-Arrhythmia Agents; D012991:Solanaceous Alkaloids; C003922:anisodamine; D015764:Bepridil