[Pulmonary complications and their prevention in the treatment of Hodgkin's disease].
Pulmonary ventilation was monitored in a group of 102 patients with Hodgkin's disease. In the initial finding a tendency of a restrictive disorder is apparent (43% of the patients) with the increasing size of the mediastinal tumour (79% mediastinal patients with a bulky finding in 40%), without statistical significance. After treatment a restrictive disorder was recorded in 35% of the patients with a normal initial finding and conversely normalization of results occurred in 12% patients with a pathological result of the spirometric examination. After a one-year interval the finding deteriorated in 12 % of the patients without post-treatment disorders of pulmonary ventilation and in 15% the assessed disorder receded. Statistical analysis did not reveal a significant relationship between the results of spirometry and bleomycin treatment. 77 patients were examined after an interval of 2, 3, 4 and more years following termination of primary treatment without a significant correlation of the development of the a restrictive disorder and bleomycin administration. Pulmonary ventilation after treatment was examined in a total of 228 patients with the finding of restrictive changes in 94 (41%). Pulmonary fibrosis was diagnosed in 21 patients (9%) with a rising incidence two years after terminated treatment.
Melínová
L
L
Pneumologickå klinika 1. LF UK, Praha.
Hermanská
Z
Z
Halíková
J
J
Dienstbier
Z
Z
Vacková
B
B
Skala
E
E
Zámecník
J
J
D000328:Adult; D006689:Hodgkin Disease / Q000628:therapy*; D006801:Humans; D008171:Lung Diseases / Q000175:diagnosis / Q000209:etiology* / Q000517:prevention & control; D008479:Mediastinal Neoplasms / Q000628:therapy; D008875:Middle Aged; D011658:Pulmonary Fibrosis / Q000209:etiology; D015656:Respiratory Mechanics; D013147:Spirometry
Plicní komplikace lécby u Hodgkinovy choroby a jejich prevence.