Drosophila warts--tumor suppressor and member of the myotonic dystrophy protein kinase family.
Tumor suppressor genes represent a broad class of genes that normally function in the negative regulation of cell proliferation. Loss-of-function mutations in these genes lead to unrestrained cell proliferation and tumor formation. A fundamental understanding of how tumor suppressor genes regulate cell proliferation and differentiation should reveal important aspects of signalling pathways and cell cycle control. A recent report describing the Drosophila tumor suppressor gene warts has implications in the study of the human myotonic dystrophy gene. These genes encode members of a cyclic AMP-dependent protein kinase subfamily that includes other plant and animal orthologues.
Watson
K L
KL
Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA.
D000818:Animals; D004330:Drosophila / Q000235:genetics* / Q000378:metabolism; D029721:Drosophila Proteins; D016147:Genes, Tumor Suppressor / Q000235:genetics; D006801:Humans; D065636:Myotonin-Protein Kinase; D011494:Protein Kinases; D017346:Protein Serine-Threonine Kinases / Q000145:classification / Q000235:genetics*
C585517:DMPK protein, human; D029721:Drosophila Proteins; D011494:Protein Kinases; C092745:LATS1 protein, human; C093503:wts protein, Drosophila; D065636:Myotonin-Protein Kinase; D017346:Protein Serine-Threonine Kinases