[18FDG whole-body PET in differentiated thyroid carcinoma. Flipflop in uptake patterns of 18FDG and 131I].
In 27 examinations of 24 patients with differentiated thyroid carcinoma an alternating pattern of metastases with either 131I- or FDG-uptake was found. In the follow-up of these patients this flip-flop pattern was seen in 89% (17/19) of patients with metastases and uptake of 131I or FDG as described here as uptake types 1 and 2 (type 1: FDG-positive and 131I-negative; type 2: FDG-negative and 131I-positive). In 4 patients a mixed type was observed (uptake type 3), i.e. a combination of metastases with uptake types 1 and 2 in the same patient. Metastases of papillary or follicular thyroid carcinoma without uptake of iodine have all been found to be FDG-positive in patients with an increase of thyroglobulin and with negative diagnostic results from other imaging modalities, and were histologically confirmed by surgery. False-negative or false-positive cases were not observed in this study. The FDG uptake showed an inverse proportionality to iodine uptake and to tumor differentiation. Increased glucose metabolism is a sign of higher malignancy.
Feine
U
U
Abteilung für Nuklearmedizin, Universität Tübingen, FRG.
Lietzenmayer
R
R
Hanke
J P
JP
Wöhrle
H
H
Müller-Schauenburg
W
W
D018263:Adenocarcinoma, Follicular / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D001692:Biological Transport; D002291:Carcinoma, Papillary / Q000000981:diagnostic imaging / Q000378:metabolism / Q000473:pathology; D002454:Cell Differentiation; D003847:Deoxyglucose / Q000031:analogs & derivatives* / Q000378:metabolism / Q000493:pharmacokinetics; D005462:Fluorine Radioisotopes / Q000493:pharmacokinetics; D019788:Fluorodeoxyglucose F18; D006801:Humans; D007457:Iodine Radioisotopes / Q000493:pharmacokinetics; D009362:Neoplasm Metastasis; D011379:Prognosis; D013964:Thyroid Neoplasms / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology; D014055:Tomography, Emission-Computed
D005462:Fluorine Radioisotopes; D007457:Iodine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose
18FDG-Ganzkörper-PET bei differenzierten Schilddrüsenkarzinomen. Flipflop im Speichermuster von 18FDG und 131J.