title: [Effects of m-nifedipine on dihydropyridine binding sites in the cell membranes of kidney and lung from left ventricular hypertrophied elderly rats].
abstract: Effects of m-nifedipine (m-Nif) on the affinity and density of dihydropyridine (DHP) binding sites in the cell membranes of kidney and lung were investigated using the LVH (left ventricular hypertrophy) induced by Goldblatt (2k-1c) renovascular hypertension in elderly rats. m-Nif markedly reduced blood pressure, left ventricular weight, and decreased the density (Bmax) of DHP binding sites in the cell membranes of kidney and lung from 699 +/- 112, 759 +/- 35 fmol.mg-1 protein to 482 +/- 29, 381 +/- 33 fmol.mg-1 protein. No difference was observed between groups in dissociation constant (KD) values of DHP binding sites. The results suggest that m-Nif could markedly decrease DHP binding sites in the membranes of kidney and lung from cardiac hypertrophied elderly rats.
authors.affiliation: Department of Cardiovascular Pharmacology, Nanjing Medical University.
authors.forename: Y
authors.initials: Y
authors.lastname: Xu
authors.forename: T
authors.initials: T
authors.lastname: Xi
authors.forename: M R
authors.initials: MR
authors.lastname: Rao
mesh_terms: D000818:Animals; D015220:Calcium Channels / Q000378:metabolism*; D020746:Calcium Channels, L-Type; D002462:Cell Membrane / Q000378:metabolism; D006978:Hypertension, Renovascular / Q000150:complications*; D017379:Hypertrophy, Left Ventricular / Q000209:etiology / Q000378:metabolism*; D007536:Isomerism; D007668:Kidney / Q000473:pathology; D008168:Lung / Q000473:pathology; D008297:Male; D009543:Nifedipine / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D011950:Receptors, Cholinergic / Q000378:metabolism*
chemical_list: D015220:Calcium Channels; D020746:Calcium Channels, L-Type; D011950:Receptors, Cholinergic; D009543:Nifedipine