[Features of transport function and structure of serum albumin in cancer].
Levels of lipid ligands in serum albumin from cancer patients were assayed versus tumor localization. Abnormal non-specific increase in albumin-bound lipids as well as in peroxidation products was found. Gas-liquid chromatography of different polynonsaturated fatty acids pointed to the enhancement of their metabolism via the omega 3 pathway. The despiralization-type changes in secondary structure of albumin identified by procedures of spectral analysis and the decline in reserve functional activity of protein in tumor patients were matched by a rise in levels of serum albumin-transported ligands. It is suggested that such increase in the ligand-binding ability of albumin provides a major adaptive factor involved in oncopatology.
Tolkacheva
N V
NV
Borisenko
S N
SN
Kulakova
S N
SN
Levachev
M M
MM
Onsovich
I N
IN
D001692:Biological Transport; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000502:physiology; D009369:Neoplasms / Q000097:blood*; D012709:Serum Albumin / Q000378:metabolism*
D012709:Serum Albumin
Kharakteristika transportnoĭ funktsii i struktury syvorotochnogo al'bumina u onkologicheskikh bol'nykh.