title: Mechanical test method on the estimation of the lubricant performance by hyaluronic acid.
abstract: Cases with loss of articular cartilage or lowering of articular lubricant performance are frequent among patients afflicted by various gonarthropathies or those fitted with prosthetic joints. The management of such cases has necessitated evaluation studies on the clinical efficacy of using high molecular weight hyaluronic acid as an artificial synovial fluid with a view to improving articular lubricant performance. The proper implementation of such evaluation studies on lubrication performance requires testing methods capable of assessing basic lubricant performance not only with respect to articular cartilage alone but also with respect to various other combinations of materials, i.e., lubrication between articular bone and artificial joints, etc. In the present study, first, a simple standard lubricant performance test using several small readily procurable test specimens was devised. Then, this test was employed to evaluate the basic lubricant properties of hyaluronic acid intended for use as artificial synovial fluid.
authors.affiliation: Department of Mechatoronics and Precision Engineering, Tohoku University, Sendai, Japan.
authors.forename: A T
authors.initials: AT
authors.lastname: Yokobori
authors.forename: T
authors.initials: T
authors.lastname: Kawaharada
authors.forename: S
authors.initials: S
authors.lastname: Sasaki
authors.forename: S
authors.initials: S
authors.lastname: Watanabe
authors.forename: S H
authors.initials: SH
authors.lastname: Fang
authors.forename: S
authors.initials: S
authors.lastname: Komatsu
authors.forename: T
authors.initials: T
authors.lastname: Hayashi
mesh_terms: D000368:Aged; D001672:Biocompatible Materials / Q000494:pharmacology*; D001696:Biomechanical Phenomena; D002240:Carbohydrate Sequence; D002358:Cartilage, Articular / Q000187:drug effects / Q000502:physiology; D005270:Femur Head / Q000502:physiology; D006801:Humans; D006820:Hyaluronic Acid / Q000737:chemistry / Q000494:pharmacology*; D066298:In Vitro Techniques; D008153:Lubrication; D008297:Male; D008422:Materials Testing; D008969:Molecular Sequence Data; D008970:Molecular Weight; D013314:Stress, Mechanical; D013582:Synovial Fluid / Q000187:drug effects* / Q000502:physiology*
chemical_list: D001672:Biocompatible Materials; D006820:Hyaluronic Acid