title: [Familial occurrence of cluster headache].
abstract: The familial occurrence of cluster headache was assessed in 421 probands with cluster headache, diagnosed according to the diagnostic criteria of the International Headache Society. The probands were from a neurological clinic and two departments of neurology. They received a mailed questionnaire regarding the presence of cluster headache among their relatives. All possibly affected relatives were interviewed by telephone. The questionnaire response rate was 88% (370/421). Seven probands belonged to three families. Familial occurrence of cluster headache was confirmed in 7% (25/366) of the families. Compared with the general population, first degree relatives of probands with cluster headache had a 14-fold increased risk of cluster headache, after standardization for sex and age. The second degree relatives had a twofold increased risk of cluster headache. The increased familial risk of cluster headache strongly suggests that cluster headache has a genetic cause.
authors.affiliation: Neurologisk afdeling, Amtssygehuset i Glostrup.
authors.forename: M B
authors.initials: MB
authors.lastname: Russell
authors.forename: P G
authors.initials: PG
authors.lastname: Andersson
authors.forename: L L
authors.initials: LL
authors.lastname: Thomsen
mesh_terms: D000328:Adult; D000368:Aged; D003027:Cluster Headache / Q000453:epidemiology / Q000235:genetics*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D011795:Surveys and Questionnaires
vernacular_title: Familiaer forekomst af klyngehovedpine.