[The nifedipine withdrawal syndrome in patients with stable stenocardia of effort].
The effect of abrupt discontinuation of nifedipine (N) on exercise tolerance and myocardial ischemia was studied in 7 patients with stable angina pectoris of effort (AP). N was administered in a dose of 20 mg 4 times a day for 34 days. Exercise treadmill tests were performed before N therapy in placebo treatment, on N treatment day 1, 28, on the first day after abrupt N discontinuation and 8 days after the latter. Upon acute and regular administration N produced a significant improvement in exercise tolerance before the onset of AP, development of moderate AP and up to 1 mm depression of ST-segment. Abrupt N discontinuation resulted in substantial deterioration in exercise performance pronounced more definitely on hour 21 and 24 after the last dose intake. A substantial increase in the sum of ST-segment depression at the onset of AP and at the development of AP of moderate severity occurred on the first day of N withdrawal. 8 days after N cessation all the exercise parameters returned to the baseline levels. We conclude that abrupt cessation of regular N therapy may cause a withdrawal syndrome which manifested with a decrease in the exercise tolerance and an increase in exercise-induced myocardial ischemia.
Martsevich
S Iu
SIu
Kutishenko
N P
NP
Metelitsa
V I
VI
D000787:Angina Pectoris / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D004562:Electrocardiography / Q000187:drug effects; D005080:Exercise Test / Q000187:drug effects; D017079:Exercise Tolerance / Q000187:drug effects; D006801:Humans; D017202:Myocardial Ischemia / Q000139:chemically induced* / Q000503:physiopathology; D009543:Nifedipine / Q000008:administration & dosage / Q000009:adverse effects*; D005082:Physical Exertion / Q000187:drug effects*; D013375:Substance Withdrawal Syndrome / Q000175:diagnosis / Q000209:etiology* / Q000503:physiopathology; D013997:Time Factors
D009543:Nifedipine
Sindrom otmeny nifedipina u bol'nykh stabil'noĭ stenokardieĭ napriazheniia.