title: Deletion 9p22-pter and loss of Y as primary chromosome abnormalities in a squamous cell carcinoma of the vocal cord.
abstract: Loss of distal 9p is a common genetic alteration in squamous cell carcinoma of the head and neck. A vocal cord lesion incorporating a carcinoma-in-situ and a focus of invasive carcinoma revealed loss of the Y chromosome and a 9p22 rearrangement with loss of 9p22-pter. Loss of 9p22-pter appears to be a primary autosomal abnormality in this squamous cell carcinoma.
authors.affiliation: Cytogenetics Laboratory, University of Michigan Cancer Center, Ann Arbor.
authors.forename: M J
authors.initials: MJ
authors.lastname: Worsham
authors.forename: M J
authors.initials: MJ
authors.lastname: Benninger
authors.forename: R J
authors.initials: RJ
authors.lastname: Zarbo
authors.forename: T E
authors.initials: TE
authors.lastname: Carey
authors.forename: D L
authors.initials: DL
authors.lastname: Van Dyke
mesh_terms: D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002872:Chromosome Deletion; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014998:Y Chromosome