Premature labor and intra-amniotic infection. Clinical aspects and role of the cytokines in diagnosis and pathophysiology.
The role of infection in the pathogenesis of preterm labor and delivery, and the specific mechanisms through which this association is demonstrated are presented. Cellular and biochemical changes that initiate parturition in the setting of infection are discussed, particularly prostaglandins and cytokines.
Gomez
R
R
Perinatology Research Branch, National Institute of Child Health and Human Development, Bethesda, Maryland, USA.
Ghezzi
F
F
Romero
R
R
Muñoz
H
H
Tolosa
J E
JE
Rojas
I
I
D000818:Animals; D001424:Bacterial Infections / Q000175:diagnosis / Q000503:physiopathology*; D002821:Chorioamnionitis / Q000175:diagnosis / Q000382:microbiology* / Q000503:physiopathology; D016207:Cytokines / Q000502:physiology*; D005260:Female; D006801:Humans; D007231:Infant, Newborn; D007743:Labor, Obstetric / Q000502:physiology; D007752:Obstetric Labor, Premature / Q000175:diagnosis / Q000382:microbiology* / Q000503:physiopathology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000503:physiopathology; D011453:Prostaglandins / Q000502:physiology; D014591:Uterine Diseases / Q000382:microbiology / Q000503:physiopathology
D016207:Cytokines; D011453:Prostaglandins