title: Increased erythrocyte calcium pump activity in a kindred with familial benign hypercalcaemia.
abstract: The hypothesis that a global defect in cellular calcium transport may be critical in the development of familial benign hypercalcaemia (FBH) was investigated. Nine hypercalcaemic patients from a kindred with FBH and nine normal subjects were evaluated. Our results indicate that calcium pump activity in the FBH kindred was significantly higher (28%, P < 0.005) when compared to normal subjects. These findings suggest that alterations in calcium pump activity in target tissues may play a role in the development of FBH.
authors.affiliation: Department of Physiology, University of Puerto Rico School of Medicine, San Juan 00936.
authors.forename: N
authors.initials: N
authors.lastname: Escobales
authors.forename: C A
authors.initials: CA
authors.lastname: Fariñas
authors.forename: L
authors.initials: L
authors.lastname: Haddock
mesh_terms: D000328:Adult; D001692:Biological Transport; D017301:Ca(2+) Mg(2+)-ATPase / Q000378:metabolism; D002118:Calcium / Q000378:metabolism; D000252:Calcium-Transporting ATPases / Q000378:metabolism / Q000502:physiology*; D004912:Erythrocytes / Q000378:metabolism*; D006801:Humans; D006934:Hypercalcemia / Q000378:metabolism*; D008875:Middle Aged; D010281:Parathyroid Hormone / Q000097:blood
chemical_list: D010281:Parathyroid Hormone; D017301:Ca(2+) Mg(2+)-ATPase; D000252:Calcium-Transporting ATPases; D002118:Calcium