Effects of tianeptine on 5-hydroxyindoles and on the morphine-induced increase in 5-HT metabolism at the medullary dorsal horn level as measured by in vivo voltammetry in freely moving rats.
The present study, by the use of in vivo electrochemical detection of 5-hydroxyindole (peak '3') in the bulbo spinal serotonergic system at the medullary dorsal horn (MDH) level, investigated the effects of the new tricyclic antidepressant (TCA) tianeptine, which has been shown to be a specific serotonin (5-HT) uptake enhancer. It was found that acutely administered tianeptine (10 mg/kg, i.p.) induced a marked significant increase in peak 3 within the dorsal horn, an in vivo observation which is in accordance with the biochemical properties of tianeptine as studied in forebrain structures. In addition, the effect of tianeptine on the morphine-induced increase in 5-HT metabolism was investigated, by comparison with the previous data obtained with the specific 5-HT uptake inhibitor femoxetine in the MDH. It was shown that tianeptine can display additive effect with morphine (10 mg/kg, i.p.) on 5-HT metabolism at the MDH level. These results are discussed in relation to the effects of classical TCAs and the particular properties of tianeptine.
Puig
S
S
Unité de Recherches de Physiopharmacologie du Système Nerveux, INSERM, U. 161, Paris, France.
Rivot
J P
JP
Besson
J M
JM
D000818:Animals; D000929:Antidepressive Agents, Tricyclic / Q000494:pharmacology*; D004563:Electrochemistry; D006897:Hydroxyindoleacetic Acid / Q000378:metabolism; D007211:Indoles / Q000378:metabolism*; D008297:Male; D008526:Medulla Oblongata / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D012701:Serotonin / Q000378:metabolism*; D013116:Spinal Cord / Q000737:chemistry / Q000187:drug effects / Q000378:metabolism*; D013841:Thiazepines / Q000494:pharmacology*
D000929:Antidepressive Agents, Tricyclic; D007211:Indoles; D013841:Thiazepines; C050504:tianeptine; D012701:Serotonin; D009270:Naloxone; D006897:Hydroxyindoleacetic Acid; D009020:Morphine