Low-dose dopamine in severe right heart failure and chronic obstructive pulmonary disease.
OBJECTIVE
To describe the beneficial effects of low-dose dopamine infusion (2-5 micrograms/kg/min) in a patient with severe cor pulmonale complicating chronic obstructive pulmonary disease (COPD).


METHODS
A 53-year-old woman with severe cor pulmonale and generalized edema complicating COPD received low-dose dopamine to stabilize blood pressure and, perhaps, improve cardiac output. Low-dose dopamine also improved her renal function and enhanced the diuretic response to furosemide therapy.


CONCLUSIONS
Previous studies of dopamine in such patients were reviewed. Both dopamine infusion (4 micrograms/kg/min) and oral administration of its precursor, L-dopa, can increase the cardiac output, decrease pulmonary vascular resistance, and enhance oxygen delivery in patients who are stable with cor pulmonale secondary to COPD. In patients with COPD during acute respiratory failure, high-dose dopamine (10 micrograms/kg/min) has been shown to increase the diaphragmatic blood flow and contraction. Low-dose dopamine also has been reported to be useful in patients with congestive heart failure or cirrhosis of the liver.


CONCLUSIONS
Low-dose dopamine is useful in the acute management of patients with severe cor pulmonale complicating COPD because of the drug's beneficial effects on blood pressure, cardiac output, renal perfusion, natriuresis, and diuresis. Low-dose dopamine also may enhance the natriuretic and diuretic response to loop diuretics, decrease pulmonary vascular resistance, and enhance oxygen delivery.
Chan
T Y
TY
Department of Clinical Pharmacology, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.
D002303:Cardiac Output, Low / Q000188:drug therapy / Q000503:physiopathology; D004298:Dopamine / Q000008:administration & dosage / Q000627:therapeutic use*; D005260:Female; D006439:Hemodynamics / Q000187:drug effects; D006801:Humans; D007262:Infusions, Intravenous; D008173:Lung Diseases, Obstructive / Q000150:complications* / Q000188:drug therapy / Q000503:physiopathology; D008875:Middle Aged; D011660:Pulmonary Heart Disease / Q000150:complications / Q000188:drug therapy* / Q000503:physiopathology; D018497:Ventricular Dysfunction, Right / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology
D004298:Dopamine