title: Susceptibility to high-altitude pulmonary edema in Madison and Hilltop rats. I. Ventilation and fluid balance.
abstract: The pathogenesis of high-altitude pulmonary edema (HAPE) is not well understood. Ventilation and fluid-handling abnormalities at high altitude (HA) may play a role in HAPE. Because ventilatory and cardiopulmonary responses to chronic HA exposure in the Hilltop (H) strain of Sprague-Dawley rat are different from those in the Madison (M) strain, it was hypothesized that these strains would have different susceptibilities to developing HAPE. M and H rats were studied at sea level (SL) and in a hypobaric chamber after 9 and 12 h at a simulated altitude of 24,000 ft (barometric pressure = 295 mmHg) and 1, 12, and 24 h at a simulated altitude of 18,000 ft (barometric pressure = 380 mmHg). Both strains developed HAPE, but the M rat was more susceptible to HAPE, as demonstrated by a higher mortality rate from hemorrhagic pulmonary edema after 9 h at 24,000 ft and an earlier increase in lung water after exposure to 18,000 ft. Minute ventilation was similar in both strains at HA, but arterial PO2 was significantly higher in the M rat. Both strains had a significant decrease in fluid intake and negative sensible water balance at HA. No changes in plasma renin activity, aldosterone concentrations, antidiuretic hormone levels, and atrial natriuretic peptide levels were found at HA. The increased susceptibility of the M rat to HAPE is therefore not explained by ventilation or fluid-handling abnormalities.
authors.affiliation: Department of Medicine, Veterans Affairs Hospital, White River Junction, Vermont 05001, USA.
authors.forename: G L
authors.initials: GL
authors.lastname: Colice
authors.forename: Y J
authors.initials: YJ
authors.lastname: Lee
authors.forename: J
authors.initials: J
authors.lastname: Chen
authors.forename: H K
authors.initials: HK
authors.lastname: Du
authors.forename: G
authors.initials: G
authors.lastname: Ramirez
authors.forename: J
authors.initials: J
authors.lastname: Dietz
authors.forename: L C
authors.initials: LC
authors.lastname: Ou
mesh_terms: D000531:Altitude; D000818:Animals; D004326:Drinking; D008168:Lung / Q000378:metabolism*; D008297:Male; D011652:Pulmonary Circulation; D011654:Pulmonary Edema / Q000209:etiology*; D012123:Pulmonary Ventilation; D051381:Rats; D017207:Rats, Sprague-Dawley; D012119:Respiration / Q000502:physiology*; D014867:Water; D014882:Water-Electrolyte Balance / Q000502:physiology*
chemical_list: D014867:Water