Acute hyperpolarization and elongation of cochlear outer hair cells on superfusion with cis-platinum.
The acute effects of cis-platinum on isolated cochlear outer hair cells (OHC) were investigated with whole-cell patch-clamps and measurements of cell length changes. Our findings demonstrated that cis-platinum reversibly induced a hyperpolarization and cellular elongation. These results suggest that the effects produced are the result of an interaction between cis-platinum and transduction channels in OHC. These acute effects are distinctly different from the chronic, irreversible ones that are followed by death of the OHC. The exact mechanism of these chronic effects remains unknown as yet.
Ernst
A
A
Department of Otolaryngology, Hannover Medical School, Germany.
Zenner
H P
HP
D000818:Animals; D002945:Cisplatin / Q000633:toxicity*; D006168:Guinea Pigs; D018072:Hair Cells, Auditory, Outer / Q000033:anatomy & histology / Q000187:drug effects* / Q000502:physiology; D066298:In Vitro Techniques; D008564:Membrane Potentials / Q000187:drug effects; D018408:Patch-Clamp Techniques
D002945:Cisplatin