Intraoperative radiation therapy in advanced thyroid cancer.
An intraoperative radiation therapy (IORT)-protocol was designed for poorly differentiated non-anaplastic thyroid carcinoma. Out of 155 cases of differentiated thyroid tumours, 12 showed marked vascular/capsular invasion. Five entered the study (three primarily local invasive tumours, two local recurring). IORT was administered after tumour surgery (4-10 GY) and combined with post-operative percutaneous irradiation. The tumour control rate in the thyroid bed was achieved in all five patients, 1/5 developed mediastinal nodes and 1/5 with primary mediastinal tumour extension showed tumour progression. No specific complications occurred.
Wolf
G
G
Division of Endocrine Surgery, University of Graz, Austria.
Geyer
E
E
Langsteger
W
W
Ramschak
S
S
Rosanelli
G
G
D018263:Adenocarcinoma, Follicular / Q000000981:diagnostic imaging* / Q000601:surgery*; D002291:Carcinoma, Papillary / Q000532:radiotherapy* / Q000601:surgery*; D005260:Female; D006801:Humans; D007432:Intraoperative Period; D008297:Male; D008875:Middle Aged; D011184:Postoperative Period; D011859:Radiography; D018714:Radiotherapy, Adjuvant / Q000379:methods; D013964:Thyroid Neoplasms / Q000473:pathology / Q000532:radiotherapy* / Q000601:surgery*; D016896:Treatment Outcome