title: Quality of life in inflammatory bowel disease: the interaction of disease activity with psychosocial function.
abstract: OBJECTIVE
  To evaluate the disease-specific and psychological factors that influence quality of life (QOL) in patients with inflammatory bowel disease (IBD) as measured by the recently developed IBD disease-specific QOL measure the Inflammatory Bowel Disease Questionnaire (IBDQ).
  
  
  METHODS
  Twenty-two patients (eight males and 14 females) were studied, 16 with Crohn's disease and six with ulcerative colitis (mean age 32 yr). Patients' disease activity was measured with the Dutch Crohn's activity index and the St. Mark's colitis activity index, and QOL was measured by the IBDQ. All patients completed self-report questionnaires for psychological function, which included the Sickness Impact Profile (SIP), the Symptom Checklist-90-R (SCL), and the Self-Control Schedule (SCS).
  
  
  RESULTS
  By combining the psychological measures and the disease activity into a single variable, this composite variable significantly predicted QOL (r = 0.53, p < 0.02), but disease activity alone did not predict overall QOL. Improved psychosocial functioning (Sickness Impact Profile) predicted greater overall QOL (IBDQ total: r = -0.49, p < 0.05) and better social functioning (r = -0.65, p < 0.01). Greater psychological distress (SCL) and disease activity predicted more systemic symptoms [SCL-Positive Symptom Total (PST): r = -0.48, p < 0.05; disease activity: r = -0.65, p < 0.03) and poorer emotional functioning (SCL-PST: r = minus] 0.75, p < 0.001; disease activity: r = -0.82, p < .03). Disease type, gender, age of onset, and psychological coping (SCS) were not predictive of disease-specific QOL, but coping (SCS) was significantly correlated with psychological distress (r = -0.58, p < 0.05 for the SCL-90-PST).
  
  
  CONCLUSIONS
  This study confirms the importance of psychological functioning in determining QOL of IBD patients and must be considered jointly with disease activity.
authors.affiliation: Department of Medicine, Camp Hill Medical Centre, Dalhousie University, Halifax, Canada.
authors.forename: G K
authors.initials: GK
authors.lastname: Turnbull
authors.forename: T M
authors.initials: TM
authors.lastname: Vallis
mesh_terms: D000223:Adaptation, Psychological; D000328:Adult; D003093:Colitis, Ulcerative / Q000453:epidemiology / Q000523:psychology*; D003424:Crohn Disease / Q000453:epidemiology / Q000523:psychology*; D005260:Female; D006801:Humans; D008297:Male; D011237:Predictive Value of Tests; D011788:Quality of Life; D012720:Severity of Illness Index; D018434:Sickness Impact Profile; D012917:Social Adjustment; D013315:Stress, Psychological / Q000453:epidemiology / Q000209:etiology*