title: Staphylococcal enterotoxin A gene (sea) expression is not affected by the accessory gene regulator (agr).
abstract: The goal of this work was to determine whether staphylococcal enterotoxin type A gene (sea) expression is regulated by an accessory gene regulator (agr). The Tn551 insertionally inactivated agr allele of Staphylococcus aureus ISP546 was transferred to three Sea+ S. aureus strains. Each of the Agr- strains produced as much staphylococcal enterotoxin A (SEA) as its parent strain. These results suggest that sea expression is regulated differently from that of seb, sec, and sed, which previously have been shown to require a functional agr system for maximal expression.
authors.affiliation: University of Wisconsin-Madison 53706.
authors.forename: M T
authors.initials: MT
authors.lastname: Tremaine
authors.forename: D K
authors.initials: DK
authors.lastname: Brockman
authors.forename: M J
authors.initials: MJ
authors.lastname: Betley
mesh_terms: D015152:Blotting, Northern; D015153:Blotting, Western; D004768:Enterotoxins / Q000096:biosynthesis*; D015964:Gene Expression Regulation, Bacterial / Q000502:physiology*; D005798:Genes, Bacterial / Q000502:physiology; D005809:Genes, Regulator / Q000502:physiology*; D007369:Interferon Inducers; D012313:RNA / Q000096:biosynthesis; D013211:Staphylococcus aureus / Q000378:metabolism
chemical_list: D004768:Enterotoxins; D007369:Interferon Inducers; C026066:enterotoxin A, Staphylococcal; C031818:enterotoxin B, staphylococcal; D012313:RNA