[Morphological studies of endocrine cells of the pancreas in rats after exposure to micro- and hypergravity].
Effects of changed gravity on the function of insulin-producing beta-cells and glucagon-producing alpha-cells in pancreas of rats after the 14-day missions of Cosmos-1887, -2044, and those pre- and postnatal development of which till day 60 proceeded at 2 G in a permanently rotating ground centrifuge were studied with the use of morphological techniques. The comparison of beta- and alpha-cells from pancreas of rats flown in space and subjected to relatively reduced gravity after transition from 2 G to 1 G in the laboratory experiment allow to deduce that the postflight reduced production of insulin by beta-cells and glucagon by alpha-cells has been caused by microgravity, whereas the hindered secretion of hormones is associated with the gravity stress within the first hours after recovery.
Alekseev
E I
EI
Krasnov
I B
IB
D000818:Animals; D005934:Glucagon / Q000378:metabolism; D018471:Hypergravity; D007328:Insulin / Q000378:metabolism; D000078790:Insulin Secretion; D007515:Islets of Langerhans / Q000166:cytology / Q000378:metabolism / Q000473:pathology*; D008297:Male; D051381:Rats; D017208:Rats, Wistar; D013026:Space Flight; D013997:Time Factors; D014893:Weightlessness
D007328:Insulin; D005934:Glucagon
Morfologicheskoe issledovanie éndokrinnykh kletok podzheludochnoĭ zhelezy krys, nakhodivshikhsia v usloviiakh mikro- i gipergravitatsii.