Temperature-dependent antimutagenic activity of acrolein in Escherichia coli.
The effect of temperature on the antimutagenic activity of acrolein was investigated using UV-irradiated E. coli B. When incubated at lower temperatures (30 degrees C or 37 degrees C), acrolein greatly reduced the mutation frequency in WP2 (wild-type strain), but no such effect was observed with WP2s and ZA159 (excision repair-deficient strains). The antimutagenic activity of acrolein increased when cells were incubated at higher temperatures (40 degrees C or 42 degrees C). Particularly in excision repair-deficient strains, the antimutagenic activity was observed only at higher temperatures. In heat shock response-deficient background, however, the antimutagenic activity was observed at 30 degrees C even in the excision repair-deficient strains.
Aikawa
K
K
National Institute of Animal Industry, Ibaraki, Japan.
Miwa
M
M
D000171:Acrolein / Q000494:pharmacology*; D016587:Antimutagenic Agents / Q000494:pharmacology*; D004249:DNA Damage; D004260:DNA Repair; D004926:Escherichia coli / Q000187:drug effects / Q000235:genetics*; D006360:Heat-Shock Proteins / Q000096:biosynthesis; D006358:Hot Temperature
D016587:Antimutagenic Agents; D006360:Heat-Shock Proteins; D000171:Acrolein