[The participation of the T system and macrophages in the immediate immune response to drug compounds].
Experiments on rats and on human lymphocytes have indicated that a prompt immune response to low-molecular-weight biologically active agents is thymus-dependent, calls for cooperative interaction of T and B lymphocytes and macrophages, it is enhanced by T mitogens and implemented through the specific pharmacological receptors of T and B lymphocytes. The findings offer ample scope for controlling the immune mechanisms of habituation to drugs and poisons.
Zaks
A S
AS
Bykova
A A
AA
Iushkova
T A
TA
D000818:Animals; D000917:Antibody Formation / Q000187:drug effects; D002478:Cells, Cultured; D004342:Drug Hypersensitivity / Q000209:etiology* / Q000276:immunology; D006801:Humans; D006969:Hypersensitivity, Immediate / Q000139:chemically induced* / Q000276:immunology; D007111:Immunity, Cellular / Q000187:drug effects; D008211:Lymphocyte Cooperation / Q000187:drug effects / Q000276:immunology; D008264:Macrophages / Q000187:drug effects* / Q000276:immunology; D008297:Male; D008970:Molecular Weight; D051381:Rats; D012397:Rosette Formation; D013601:T-Lymphocytes / Q000187:drug effects* / Q000276:immunology; D013934:Thymectomy
Uchastie T-sistemy i makrofagov v nemedlennom immunnom otvete na lekarstvennye soedineniia.