title: Rearrangements involving 12p12 in two cases of cardiac myxoma.
abstract: Recently, we reported on the cytogenetic analysis of a case of cardiac myxoma, revealing a 46,XY,der(7)t(7;17)(p21;p11), add (10) (q22), add (12) (p12), del(17)(p11) chromosomal pattern. In this article we present the cytogenetic analysis of another case of cardiac myxoma, in which we found several clonal and nonclonal abnormalities including dicentric chromosomes and telomeric associations (tas). One of the clonal aberrations was a translocation between chromosomes 1 and 12, involving a breakpoint at 12p12, as observed in the case described earlier. This finding suggest that 12p12 might play an important role in the histogenesis of cardiac myxomas.
authors.affiliation: Department of Medical Genetics, University of Groningen, The Netherlands.
authors.forename: T
authors.initials: T
authors.lastname: Dijkhuizen
authors.forename: E
authors.initials: E
authors.lastname: van den Berg
authors.forename: W M
authors.initials: WM
authors.lastname: Molenaar
authors.forename: J J
authors.initials: JJ
authors.lastname: Meuzelaar
authors.forename: B
authors.initials: B
authors.lastname: de Jong
mesh_terms: D000368:Aged; D002881:Chromosomes, Human, Pair 12; D015321:Gene Rearrangement / Q000235:genetics*; D006338:Heart Neoplasms / Q000235:genetics*; D006801:Humans; D007621:Karyotyping; D008297:Male; D009232:Myxoma / Q000235:genetics*