Excitotoxicity as a stochastic process.
1. Neuronal death following excitotoxic insult appears to be a stochastic process involving transition through an intermediate biochemical state. 2. Hydrogen ion accumulation in the hours after toxic glutamate exposure may indicate that this transition has occurred.
Dubinsky
J M
JM
Department of Physiology, University of Minnesota, Minneapolis 55455, USA.
D000818:Animals; D002545:Brain Ischemia / Q000473:pathology; D016923:Cell Death / Q000187:drug effects; D002478:Cells, Cultured; D018698:Glutamic Acid / Q000633:toxicity*; D006624:Hippocampus / Q000166:cytology / Q000187:drug effects; D006863:Hydrogen-Ion Concentration; D009474:Neurons / Q000187:drug effects / Q000473:pathology*; D009498:Neurotoxins / Q000633:toxicity*; D011522:Protons; D051381:Rats; D013269:Stochastic Processes
D009498:Neurotoxins; D011522:Protons; D018698:Glutamic Acid