title: Non-islet-cell tumor associated with hypoglycemia in a child: successful long-term therapy with growth hormone.
abstract: Hypoglycemia occurred in a 2-year-old girl with neuroblastoma. Initially, growth hormone secretion was suppressed, and she had low levels of insulin-like growth factor (IGF)-I and IGF binding protein-3, but elevated levels of large molecular weight IGF-II. We postulated that the pathogenesis of her hypoglycemia involved production of IGF-II by her neuroblastoma, leading to GH suppression and an abnormally elevated ratio of IGF to IGF binding protein. She was successfully treated with growth hormone; treatment was associated with normalization of the growth hormone-dependent growth factor levels and with euglycemia.
authors.affiliation: Department of Pediatrics, Children's Hospital of Boston, Harvard University School of Medicine, Massachusetts, USA.
authors.forename: M S
authors.initials: MS
authors.lastname: Agus
authors.forename: L E
authors.initials: LE
authors.lastname: Katz
authors.forename: M
authors.initials: M
authors.lastname: Satin-Smith
authors.forename: A T
authors.initials: AT
authors.lastname: Meadows
authors.forename: R L
authors.initials: RL
authors.lastname: Hintz
authors.forename: P
authors.initials: P
authors.lastname: Cohen
mesh_terms: D007516:Adenoma, Islet Cell; D000310:Adrenal Gland Neoplasms / Q000150:complications* / Q000235:genetics / Q000628:therapy; D001786:Blood Glucose / Q000032:analysis; D002675:Child, Preschool; D003131:Combined Modality Therapy; D005260:Female; D013006:Growth Hormone / Q000627:therapeutic use*; D006801:Humans; D007003:Hypoglycemia / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D007334:Insulin-Like Growth Factor I / Q000032:analysis; D007335:Insulin-Like Growth Factor II / Q000032:analysis; D009364:Neoplasm Recurrence, Local / Q000150:complications / Q000235:genetics / Q000628:therapy; D009447:Neuroblastoma / Q000150:complications* / Q000235:genetics / Q000628:therapy; D010190:Pancreatic Neoplasms; D013997:Time Factors
chemical_list: D001786:Blood Glucose; D007334:Insulin-Like Growth Factor I; D007335:Insulin-Like Growth Factor II; D013006:Growth Hormone