Percutaneous absorption of indomethacin from pluronic F127 gels in rats.
Thermally reversible gels of the poly(oxyethylene)-poly (oxypropylene)-(polyoxyethylene) triblock copolymer, Pluronic F127, were evaluated as vehicles for the percutaneous administration of drugs using indomethacin as a model drug. In-vivo percutaneous absorption studies using a rat model suggest that a 20% w/w aqueous gel of Pluronic F127 may be of practical use as a base for topical administration of the drug. The addition of isopropyl myristate or (+)-limonene to the gel formulation significantly improved percutaneous absorption, particularly when the gel was applied using an occlusive dressing technique.
Miyazaki
S
S
Faculty of Pharmaceutical Sciences, Health Science University of Hokkaido, Japan.
Tobiyama
T
T
Takada
M
M
Attwood
D
D
D000818:Animals; D000972:Antineoplastic Agents, Phytogenic / Q000494:pharmacology; D053138:Cyclohexenes; D005079:Excipients; D005782:Gels; D007213:Indomethacin / Q000008:administration & dosage / Q000493:pharmacokinetics*; D000077222:Limonene; D008297:Male; D009226:Myristates / Q000494:pharmacology; D011060:Poloxalene; D051381:Rats; D017208:Rats, Wistar; D012869:Skin Absorption / Q000187:drug effects*; D013729:Terpenes / Q000494:pharmacology
D000972:Antineoplastic Agents, Phytogenic; D053138:Cyclohexenes; D005079:Excipients; D005782:Gels; D009226:Myristates; D013729:Terpenes; C008205:isopropyl myristate; D011060:Poloxalene; D000077222:Limonene; D007213:Indomethacin