Evidence for 5-hydroxytryptamine1A receptor involvement in the control of prolactin secretion in man.
The effects of pindolol pretreatment (2 days) on prolactin and cortisol responses to a single dose of (+)-fenfluramine (30 mg po) were examined in nine healthy male volunteers. Pindolol pretreatment attenuated the (+)-fenfluramine-induced increase in prolactin concentrations but failed to affect the (+)-fenfluramine-induced cortisol increase. These data provide evidence in support of 5-HT1A receptor involvement in the regulation of prolactin secretion but question its importance in the regulation of cortisol secretion in man.
Palazidou
E
E
Department of Psychiatry, Royal London Hospital, St Clement's, UK.
Stephenson
J
J
Butler
J
J
Coskeran
P
P
Chambers
S
S
McGregor
A M
AM
D000328:Adult; D005277:Fenfluramine / Q000494:pharmacology; D006801:Humans; D006854:Hydrocortisone / Q000097:blood; D008297:Male; D010869:Pindolol / Q000494:pharmacology*; D011388:Prolactin / Q000097:blood / Q000378:metabolism*; D011985:Receptors, Serotonin / Q000187:drug effects / Q000502:physiology*; D013997:Time Factors
D011985:Receptors, Serotonin; D005277:Fenfluramine; D011388:Prolactin; D010869:Pindolol; D006854:Hydrocortisone