title: Nicotine inhibits cytokine synthesis by mouse colonic mucosa.
abstract: We examined the in vivo effect of nicotine on the synthesis of (pro)inflammatory mediators by mouse colonic mucosa. The synthesis of lipid mediators such as the prostanoids prostaglandin E2, 6-keto-prostaglandin F1 alpha and thromboxane B2, the 5-lipoxygenase products leukotriene B4 and leukotriene C4 and the platelet activating factor was not affected, whereas the synthesis of the pro-inflammatory cytokines interleukin-1 beta and tumor necrosis factor alpha was completely abolished. The beneficial effects of smoking and nicotine in ulcerative colitis could be attributed to this inhibition.
authors.affiliation: Department of Pharmacology, Erasmus University Rotterdam, Netherlands.
authors.forename: J P
authors.initials: JP
authors.lastname: Van Dijk
authors.forename: G S
authors.initials: GS
authors.lastname: Madretsma
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Keuskamp
authors.forename: F J
authors.initials: FJ
authors.lastname: Zijlstra
mesh_terms: D015121:6-Ketoprostaglandin F1 alpha / Q000096:biosynthesis; D000818:Animals; D003093:Colitis, Ulcerative / Q000188:drug therapy; D003106:Colon / Q000187:drug effects* / Q000378:metabolism; D016207:Cytokines / Q000096:biosynthesis*; D015232:Dinoprostone / Q000096:biosynthesis; D005260:Female; D007375:Interleukin-1 / Q000037:antagonists & inhibitors; D007413:Intestinal Mucosa / Q000187:drug effects / Q000378:metabolism; D007975:Leukotriene B4 / Q000096:biosynthesis; D017997:Leukotriene C4 / Q000096:biosynthesis; D051379:Mice; D008807:Mice, Inbred BALB C; D009538:Nicotine / Q000008:administration & dosage / Q000494:pharmacology*; D010972:Platelet Activating Factor / Q000096:biosynthesis; D011453:Prostaglandins / Q000096:biosynthesis; D013929:Thromboxane B2 / Q000096:biosynthesis; D014409:Tumor Necrosis Factor-alpha / Q000037:antagonists & inhibitors
chemical_list: D016207:Cytokines; D007375:Interleukin-1; D010972:Platelet Activating Factor; D011453:Prostaglandins; D014409:Tumor Necrosis Factor-alpha; D007975:Leukotriene B4; D017997:Leukotriene C4; D013929:Thromboxane B2; D015121:6-Ketoprostaglandin F1 alpha; D009538:Nicotine; D015232:Dinoprostone