title: 11q deletions in human colorectal carcinomas: cytogenetics and restriction fragment length polymorphism analysis.
abstract: Deletions and/or allelic losses of a portion of the long arm of chromosome 11 were discovered by cytogenetic and restriction fragment length polymorphism analyses in 23 of 39 (59%) informative cases of colorectal carcinoma. By comparing the patterns of loss of heterozygosity and chromosome rearrangements in different patients, we could map a common target region to 11q22-23. This region may contain a tumor suppressor gene, the inactivation of which may be involved in the development of tumors of the large intestine. The subgroup of malignancies with 11q alterations seemed to be enriched by tumors that were located in the rectum, that were Dukes' stage A, and that were well differentiated and mucin producing.
authors.affiliation: Department of Cytogenetics, Cancer Research Center, Moscow, Russia.
authors.forename: P L
authors.initials: PL
authors.lastname: Keldysh
authors.forename: T A
authors.initials: TA
authors.lastname: Dragani
authors.forename: E W
authors.initials: EW
authors.lastname: Fleischman
authors.forename: L N
authors.initials: LN
authors.lastname: Konstantinova
authors.forename: A G
authors.initials: AG
authors.lastname: Perevoschikov
authors.forename: M A
authors.initials: MA
authors.lastname: Pierotti
authors.forename: G
authors.initials: G
authors.lastname: Della Porta
authors.forename: B P
authors.initials: BP
authors.lastname: Kopnin
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002871:Chromosome Banding; D002872:Chromosome Deletion; D002880:Chromosomes, Human, Pair 11; D015179:Colorectal Neoplasms / Q000235:genetics*; D005260:Female; D016147:Genes, Tumor Suppressor; D006801:Humans; D008297:Male; D008875:Middle Aged; D012150:Polymorphism, Restriction Fragment Length