[Effects of prostacyclin MM-706 on liver function restoration in dogs after severe hemorrhagic shock].
The new synthetic analogue of prostaglandin I2 (prostacyclin MM-706) influence on some hepatic function indexes was studied up in 7 dogs with an acute hepatic insufficiency caused by severe hemorrhagic shock. Rapid and steady normalization of indexes and the animals survival were promoted by intravenous infusion of MM-706 given in 300 ng/kg dose together with hemocorrector named lactoprotein given in 10 ml/kg dose (7,5 +/- 1,4) hours later. Possible action mechanisms of the MM-706 therapeutic efficacy are considered. Results of investigation performed constitute an experimental base of the MM-706 application in the complex treatment of an acute hepatic insufficiency of different genesis in the clinic.
Pavlovskiĭ
M P
MP
Oborin
O M
OM
Lille
Iu E
IuE
Lopp
M I
MI
Zubachik
R M
RM
D000818:Animals; D004285:Dogs; D011464:Epoprostenol / Q000031:analogs & derivatives* / Q000494:pharmacology* / Q000627:therapeutic use; D005260:Female; D008099:Liver / Q000187:drug effects* / Q000503:physiopathology; D017114:Liver Failure, Acute / Q000188:drug therapy / Q000209:etiology / Q000503:physiopathology; D008111:Liver Function Tests; D008297:Male; D012771:Shock, Hemorrhagic / Q000188:drug therapy* / Q000503:physiopathology
D011464:Epoprostenol
Vplyv prostatsyklinu MM-706 na vidnovlennia funktsiĭ pechinky u sobak pislia tiazhkoho hemorahichnoho shoku.