Urinary concentration of a specific peptide of type I collagen of bone (CrossLaps): correlation to hydroxyproline.
Urinary bone resorption markers, CrossLaps and hydroxyproline are compared in a non-selected group of 93 women. The correlation between CrossLaps and hydroxyproline is satisfactory. The r value is 0.79. Furthermore, it is investigated whether CrossLaps can substitute for hydroxyproline in the estimation of bone loss, using a model based on the combination of several biochemical markers. The results indicate that the two systems reflect related or parallel events, and show that CrossLaps is suitable for use in a normal clinical chemistry laboratory.
Silsand
T
T
Department of Clinical Chemistry, Telemark Central Hospital, Porsgrunn, Norway.
Reine
A
A
Dugal
S
S
Lunde
T
T
Smedsrud
B
B
Seeberg
T
T
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D015415:Biomarkers; D001842:Bone and Bones / Q000737:chemistry*; D003094:Collagen / Q000652:urine*; D005260:Female; D006801:Humans; D006909:Hydroxyproline / Q000652:urine*; D007118:Immunoassay; D008875:Middle Aged; D015663:Osteoporosis, Postmenopausal / Q000652:urine; D010455:Peptides / Q000652:urine; D012680:Sensitivity and Specificity
D015415:Biomarkers; D010455:Peptides; D003094:Collagen; D006909:Hydroxyproline