title: [The study of relationship between c-erbB2 expression and cytoimmunology in ovarian carcinoma and its antisense regulation].
abstract: The relationship between c-erbB2 expression and cytoimmunology in ovarian carcinoma cell lines was studied; the synthesized and modified c-erbB2 antisense oligodeoxynucleotide was tested for its ability to reduce over-expression of c-erbB2. The results showed that over-expression of c-erbB2 in ovarian carcinoma could induce resistance to tumor necrosis factor (TNF) and lymphokine activated killer (LAK) cells but had no effect on H2O2; c-erbB2 antisense oligodeoxynucleotide could specifically reduce the over-expression of c-erbB2 and increase the sensitivity of ovarian cancer targets to lysis by TNF and LAK cells.
authors.affiliation: Obstet and Gynecol Hospital, Shanghai Medical University.
authors.forename: Z
authors.initials: Z
authors.lastname: Jin
authors.forename: X
authors.initials: X
authors.lastname: Zhang
authors.forename: Y
authors.initials: Y
authors.lastname: Feng
mesh_terms: D001483:Base Sequence; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D018734:Genes, erbB-2; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
chemical_list: D016376:Oligonucleotides, Antisense; D014409:Tumor Necrosis Factor-alpha