Oral bioavailability and pharmacokinetics of baquiloprim in dwarf goats.
The pharmacokinetics of baquiloprim at a dose of 8 mg kg-1 bodyweight were determined after its intravenous and intra-ruminal administration to seven healthy female dwarf goats. After intravenous injection, the plasma elimination curve showed a rapid distribution phase (mean [SD] t1/2 alpha 0.89 [0.4] hours). The mean volume of distribution at steady-state (Vdss) was 14.1 (2.7) litres kg-1 bodyweight. The mean elimination half-life (t1/2 beta) was 14.0 (2.3) hours. After intra-ruminal administration its maximum concentration in plasma (Cmax) was 0.09 (0.01 microgram ml-1 and this maximum was not reached until approximately 35 hours after administration. The systemic oral bioavailability, calculated up to 48 hours after dosing, was 33.7 (7.1) per cent. Owing to a prolonged absorption phase, the data from only four of the goats fitted reasonably to a compartmental model.
Lewicki
J
J
Department of Veterinary Basic Sciences, Utrecht University, The Netherlands.
Maas
R F
RF
Witkamp
R F
RF
Van-Miert
A S
AS
D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D005260:Female; D006041:Goats / Q000378:metabolism*; D007275:Injections, Intravenous; D011743:Pyrimidines / Q000008:administration & dosage / Q000493:pharmacokinetics*
D011743:Pyrimidines; C072761:baquiloprim