MRI demonstration of impairment of the blood-CSF barrier by glucose administration to the thiamin-deficient rat brain.
Contrast-enhanced T1-weighted spin-echo magnetic resonance imaging (MRI) has demonstrated that Gd-diethylenetriaminepentaacetate (Gd-DTPA), which normally does not cross the blood-brain or blood-CSF barriers, does so approximately 40 min after administration of glucose to a vitamin B1 deficient rat. The period of the onset of this blood-CSF or blood-brain barrier dysfunction coincides with our previous observations of accumulation of glutamate or glutamate derivatives following an equivalent glucose load under identical conditions of thiamin deficiency, consistent with a relationship between these two observations. The dysfunction was reversed when a thiamin deficient animal was made thiamin replete.
Zelaya
F O
FO
Centre for Magnetic Resonance, University of Queensland, St. Lucia, Brisbane, Australia.
Rose
S E
SE
Nixon
P F
PF
Wholohan
B T
BT
Bower
A J
AJ
Zimitat
C
C
Schoutrop
J
J
Doddrell
D M
DM
D000818:Animals; D001812:Blood-Brain Barrier / Q000187:drug effects*; D001921:Brain / Q000473:pathology; D003287:Contrast Media / Q000493:pharmacokinetics; D005260:Female; D005682:Gadolinium / Q000493:pharmacokinetics; D019786:Gadolinium DTPA; D005947:Glucose / Q000494:pharmacology*; D008279:Magnetic Resonance Imaging; D009942:Organometallic Compounds / Q000493:pharmacokinetics; D004369:Pentetic Acid / Q000031:analogs & derivatives / Q000493:pharmacokinetics; D051381:Rats; D017208:Rats, Wistar; D013832:Thiamine Deficiency / Q000473:pathology / Q000503:physiopathology*; D014899:Wernicke Encephalopathy / Q000503:physiopathology
D003287:Contrast Media; D009942:Organometallic Compounds; D004369:Pentetic Acid; D005682:Gadolinium; D005947:Glucose; D019786:Gadolinium DTPA