title: [A comparative analysis of the effect of nootropic preparations with different chemical structures on the failure of the escape reaction in rats].
abstract: The nootropic agents pyroglutamyl-D-alanine amide (TGS-20), mechlofenoxate, and mexidole versus piracetam were tested for their effects on the reversible impairments of cognitive brain functions, on the demolition of active avoidance responses in rats. TGS-20 (1 mg/kg/day) and mexidole (10 mg/kg/day) injected intraperitoneally 30 minutes prior to the experiment showed a normalizing effect in smaller doses than did piracetam (300 mg/kg/day). Mechlofenoxate (50 mg/kg/day) displayed a lower protective effect.
authors.forename: A N
authors.initials: AN
authors.lastname: Inozemtsev
authors.forename: P L
authors.initials: PL
authors.lastname: Pragina
authors.forename: F A
authors.initials: FA
authors.lastname: Firova
authors.forename: S S
authors.initials: SS
authors.lastname: Trofimov
authors.forename: T A
authors.initials: TA
authors.lastname: Gudasheva
authors.forename: N A
authors.initials: NA
authors.lastname: Tushmalova
authors.forename: R U
authors.initials: RU
authors.lastname: Ostrovskaia
authors.forename: T A
authors.initials: TA
authors.lastname: Voronina
mesh_terms: D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects*; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology*; D051381:Rats; D018709:Statistics, Nonparametric; D013329:Structure-Activity Relationship
chemical_list: D018697:Nootropic Agents
vernacular_title: Sravnitel'nyĭ analiz vliianiia nootropnykh preparatov razlichnoĭ khimicheskoĭ struktury na sboĭ reaktsii izbeganiia u krys.