Early intervention in patients with heart failure and left ventricular dysfunction.
The focus of this article is to review the process of left ventricular remodeling and discuss the results of several published large clinical trials that have demonstrated the benefit of early intervention in heart failure to prevent left ventricular remodeling and progression of cardiac dysfunction. The knowledge gained from this review should help define a strategy for the internist to initiate therapy early in the course of development of heart failure.
Deedwania
P C
PC
Department of Medicine, Veterans Affairs Medical Center, Fresno, California, USA.
D000806:Angiotensin-Converting Enzyme Inhibitors / Q000627:therapeutic use; D002986:Clinical Trials as Topic; D006333:Heart Failure / Q000150:complications / Q000188:drug therapy* / Q000401:mortality; D006801:Humans; D009203:Myocardial Infarction / Q000209:etiology; D005996:Nitroglycerin / Q000627:therapeutic use; D011379:Prognosis; D013997:Time Factors; D018487:Ventricular Dysfunction, Left / Q000188:drug therapy* / Q000209:etiology
D000806:Angiotensin-Converting Enzyme Inhibitors; D005996:Nitroglycerin