Endothelin-1 induces neutrophil-independent vascular injury in the rat gastric microcirculation.
Local intra-arterial infusion of picomole quantities of endothelin-1 induced gastric vascular leakage of radiolabelled albumin. This leakage was partially inhibited by the platelet activating factor (PAF) receptor antagonist WEB 2086 (0.5-2 mg kg-1), but was unaffected by the thromboxane synthase inhibitor OKY 1581 (5 mg kg-1) or by pretreatment with anti-neutrophil serum. These results indicate a partial role of PAF, but demonstrate that neutrophils are not involved in the gastric vascular dysfunction induced by locally administered endothelin-1.
Lopez-Belmonte
J
J
Wellcome Foundation Limited, Beckenham, Kent, UK.
Whittle
B J
BJ
D000818:Animals; D001381:Azepines / Q000008:administration & dosage / Q000494:pharmacology; D002199:Capillary Permeability / Q000187:drug effects*; D004195:Disease Models, Animal; D016232:Endothelins / Q000008:administration & dosage / Q000633:toxicity*; D004730:Endothelium, Vascular / Q000187:drug effects* / Q000293:injuries; D005753:Gastric Mucosa / Q000098:blood supply* / Q000187:drug effects; D007261:Infusions, Intra-Arterial; D007553:Isotope Labeling; D008297:Male; D008689:Methacrylates / Q000008:administration & dosage / Q000494:pharmacology; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects; D010972:Platelet Activating Factor / Q000037:antagonists & inhibitors / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism; D013276:Stomach Ulcer / Q000139:chemically induced; D013930:Thromboxane-A Synthase / Q000037:antagonists & inhibitors; D014230:Triazoles / Q000008:administration & dosage / Q000494:pharmacology
D001381:Azepines; D016232:Endothelins; D008689:Methacrylates; D010972:Platelet Activating Factor; D012709:Serum Albumin; D014230:Triazoles; C052518:WEB 2086; C031517:2-methyl-3-(4-(3-pyridinylmethyl)phenyl)-2-propenoic acid; D013930:Thromboxane-A Synthase