[A study on the mechanism of the cardiac adenylyl cyclase activity alteration in septic rats].
The present work showed that cardiac sarcolemmal (SL) adenylyl cyclase (AC) and purified AC maximal activity of septic rat (cecal ligaation and puncture, CLP) were significantly increased during the early sepsis (ES, CLP 9 h) but decreased in the late sepsis (LS, CLP 18 h). Similar alterations were observed in cardiac sarcolemmal protein kinase C (PKC) activity. Sensitization and desensitization of rat SL adenylyl cyclase during ES and LS were respectively correlated with activition and inhibition of PKC. The biphasic changes of AC and PKC were independent of beta- and alpha 1-adrenergic receptor systems. The rat cardiac sarcolemmal PKC activation and AC sensitization during ES is related to M-cholinergic receptor system. The system, however, is not involved during the LS PKC inhibition and AC desensitization.
Yang
Q
Q
Beijing Medical University, Institute of Cardiovascular Basic Research.
Tang
X
X
Tang
C S
CS
D000262:Adenylyl Cyclases / Q000378:metabolism*; D000818:Animals; D008297:Male; D009206:Myocardium / Q000201:enzymology*; D011493:Protein Kinase C / Q000378:metabolism; D051381:Rats; D017207:Rats, Sprague-Dawley; D012508:Sarcolemma / Q000201:enzymology; D018805:Sepsis / Q000201:enzymology*
D011493:Protein Kinase C; D000262:Adenylyl Cyclases