title: Retro-orbital late relapse in a child with leukaemia after allogeneic bone marrow transplantation.
abstract: Relapse after allogeneic bone marrow transplantation (BMT) usually occurs in the bone marrow and is often associated with a poor prognosis. Isolated extramedullary relapse following BMT is exceedingly rare. We observed an isolated relapse in the left retro-orbital region of a 13-year-old girl, 3 years after BMT performed for acute lymphoblastic leukaemia in third complete remission. Computerized tomography revealed a tumor at the inferomedial part of the orbit infiltrating the maxillary and ethmoid sinuses and nasal cavities and also involving the rectus muscles. Histology demonstrated a monomorphic leukaemia infiltrate. Complete disappearance of the retro-orbital mass was obtained with chemotherapy and local irradiation.
authors.affiliation: Department of Paediatric Haematology, Milan University, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Colombini
authors.forename: A
authors.initials: A
authors.lastname: Barzaghi
authors.forename: M
authors.initials: M
authors.lastname: Castagneto
authors.forename: G
authors.initials: G
authors.lastname: Bovo
authors.forename: M R
authors.initials: MR
authors.lastname: Rossi
authors.forename: A
authors.initials: A
authors.lastname: Rovelli
authors.forename: C
authors.initials: C
authors.lastname: Uderzo
mesh_terms: D000293:Adolescent; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D009918:Orbital Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction