title: Effects of intraoperative topical mitomycin-C on strabismus surgery in the rabbit: a preliminary study.
abstract: The effect of intraoperative topical exposure of mitomycin-C (MMC) on muscle reattachment and scarring in strabismus surgery was prospectively investigated in the rabbit by performing bilateral recession surgery in which one eye was treated with topical MMC (0.2 mg/mL) and the other eye served as the control. One week postoperatively, in random, masked fashion, the severity of postoperative adhesions was rated lower in the MMC-treated eyes. Also, histology demonstrated decreased fibrosis in the muscle reattachment sites in the MMC-treated eyes. The muscle tension in the reattached muscles was greater than 100 g in all of the eyes. This preliminary study indicates that topical MMC exposure may inhibit scarring in strabismus surgery without inhibiting muscle reattachment or causing other obvious adverse effects.
authors.affiliation: Anheuser-Busch Eye Institute, St Louis University School of Medicine, Mo., USA.
authors.forename: O A
authors.initials: OA
authors.lastname: Cruz
authors.forename: L
authors.initials: L
authors.lastname: Matkovich
mesh_terms: D000287:Administration, Topical; D000818:Animals; D005355:Fibrosis / Q000517:prevention & control; D007430:Intraoperative Care; D016685:Mitomycin / Q000008:administration & dosage / Q000494:pharmacology*; D009801:Oculomotor Muscles / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D009883:Ophthalmic Solutions; D010865:Pilot Projects; D011183:Postoperative Complications / Q000517:prevention & control; D011446:Prospective Studies; D011817:Rabbits; D011897:Random Allocation; D013285:Strabismus / Q000601:surgery*; D000267:Tissue Adhesions / Q000517:prevention & control
chemical_list: D009883:Ophthalmic Solutions; D016685:Mitomycin