Cytogenetic demonstration of gene amplification in a primary intracranial germ cell tumor.
We report the cytogenetic analysis of a primary pineal germinoma. The modal chromosome number was 81. Multiple numerical and structural chromosome abnormalities were noted along with a large homogeneously staining region (HSR). No isochromosome 12p was identified.
Albrecht
S
S
Department of Pathology (Neuropathology), Baylor College of Medicine, Houston, Texas 77030.
Armstrong
D L
DL
Mahoney
D H
DH
Cheek
W R
WR
Cooley
L D
LD
D000782:Aneuploidy; D001932:Brain Neoplasms / Q000235:genetics*; D002648:Child; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000032:analysis*; D005784:Gene Amplification; D006801:Humans; D007621:Karyotyping; D008297:Male; D009364:Neoplasm Recurrence, Local; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D010870:Pineal Gland; D011519:Proto-Oncogenes
D004273:DNA, Neoplasm