Immunological analysis of the plasmid-encoded proteins from the highly pathogenic Yersinia enterocolitica serogroup O8 and the less pathogenic serogroup O3.
The plasmid-encoded proteins of the pathogenic Yersinia enterocolitica serogroups O3 and O8 were analysed with respect to their immunological relationship. Common epitopes on yersinia outer-membrane proteins (YOPs) and released proteins (RPs) were recognised by orally-induced antisera against living bacteria and by monospecific antisera induced against single RPs of Y. enterocolitica serogroup O8. A major difference between the pathogenic serogroups O3 and O8 was YOP42, which was detected only in the outer membrane of the highly pathogenic O8+ bacteria. The YOP42 may be responsible for the greater virulence of serogroup O8 bacteria.
Naumann
M
M
Abteilung Innere Medizin mit Schwerpunkt Gastroenterologie, Freien Universität Berlin, Germany.
Hanski
C
C
Grützkau
A
A
D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis / Q000276:immunology; D001425:Bacterial Outer Membrane Proteins / Q000235:genetics / Q000276:immunology; D001426:Bacterial Proteins / Q000235:genetics / Q000276:immunology*; D003429:Cross Reactions; D000939:Epitopes / Q000235:genetics / Q000276:immunology; D015151:Immunoblotting; D010957:Plasmids; D011817:Rabbits; D012703:Serotyping; D015008:Yersinia enterocolitica / Q000145:classification / Q000276:immunology* / Q000472:pathogenicity
D000907:Antibodies, Bacterial; D001425:Bacterial Outer Membrane Proteins; D001426:Bacterial Proteins; D000939:Epitopes