Isoniazid-associated rhabdomyolysis.
We report the occurrence of rhabdomyolysis and hepatitis in a 17-year-old girl after the ingestion of up to 10.8 g of isoniazid. The initial isoniazid concentration in the blood was 1,230 mmol/L. There were no findings indicating the ingestion of other substances known to be associated with rhabdomyolysis. In addition to rhabdomyolysis (peak creatine phosphokinase 88,000 U/L), the patient had a significant elevation of her liver enzymes (peak aspartate aminotransferase 1,980 U/L). She recovered completely without evidence of liver or renal damage. Rhabdomyolysis and isoniazid-induced hepatitis are complications that should be considered when caring for patients with acute isoniazid ingestion.
Blowey
D L
DL
Division of Clinical Pharmacology and Toxicology, Hospital for Sick Children, University of Toronto, Ontario, Canada.
Johnson
D
D
Verjee
Z
Z
D000293:Adolescent; D002606:Charcoal / Q000627:therapeutic use; D056486:Chemical and Drug Induced Liver Injury / Q000201:enzymology; D003975:Diazepam / Q000627:therapeutic use; D005260:Female; D006801:Humans; D007538:Isoniazid / Q000097:blood / Q000506:poisoning*; D011736:Pyridoxine / Q000627:therapeutic use; D012206:Rhabdomyolysis / Q000139:chemically induced*; D012640:Seizures / Q000139:chemically induced / Q000188:drug therapy
D002606:Charcoal; D011736:Pyridoxine; D003975:Diazepam; D007538:Isoniazid