title: Linkage analyses of chromosome 18 markers do not identify a major susceptibility locus for bipolar affective disorder in the Old Order Amish.
abstract: Previously reported linkage of bipolar affective disorder to DNA markers in the pericentromeric region of chromosome 18 was reexamined in a larger homogeneous sample of Old Order Amish families. Four markers (D18S21, D18S53, D18S44, and D18S40) were examined in three kindreds containing 31 bipolar I (BP I) individuals. Although linkage findings were replicated in the one previously studied Amish pedigree containing four BP I individuals, linkage to this region was excluded in the larger sample. If a susceptibility locus for bipolar disorder is located in this region of chromosome 18, it is of minor significance in this population.
authors.affiliation: Child Study Center, Yale University School of Medicine, New Haven, CT 06510-8009, USA.
authors.forename: D L
authors.initials: DL
authors.lastname: Pauls
authors.forename: J
authors.initials: J
authors.lastname: Ott
authors.forename: S M
authors.initials: SM
authors.lastname: Paul
authors.forename: C R
authors.initials: CR
authors.lastname: Allen
authors.forename: C S
authors.initials: CS
authors.lastname: Fann
authors.forename: J P
authors.initials: JP
authors.lastname: Carulli
authors.forename: K M
authors.initials: KM
authors.lastname: Falls
authors.forename: C A
authors.initials: CA
authors.lastname: Bouthillier
authors.forename: T C
authors.initials: TC
authors.lastname: Gravius
authors.forename: T P
authors.initials: TP
authors.lastname: Keith
mesh_terms: D001714:Bipolar Disorder / Q000235:genetics*; D002874:Chromosome Mapping; D002887:Chromosomes, Human, Pair 18; D005006:Ethnicity / Q000235:genetics*; D005260:Female; D008040:Genetic Linkage; D005819:Genetic Markers; D005838:Genotype; D006801:Humans; D008126:Lod Score; D008297:Male
chemical_list: D005819:Genetic Markers