title: Hyperthermic therapy for HIV infection.
abstract: The objective of this paper is to review what is known about the antiviral effects of fever and to highlight the scientific evidence supporting the hypothesis that hyperthermic therapy may prove to be a beneficial treatment modality for persons infected with HIV. Our hyperthermic hypothesis is based upon the mutant escape, quasispecies theory of HIV antigenic diversity. We propose that, if initiated during the asymptomatic stage of HIV infection, hyperthermia may prove to decrease the number of mutant HIV strains arising due to evolutionary pressures created by the patient's immune system, with a resultant prolongation of the asymptomatic period of infection. A review of the literature from three areas of investigation: the immune response to fever, heat as a tumor killing agent, and preliminary studies with fever and retroviral infections, strongly suggests that there is a good scientific basis for the use of hyperthermic therapy in a multimodal treatment approach to HIV infection.
authors.affiliation: Department of Pathology, College of Veterinary and Biomedical Sciences, Colorado State University, Ft Collins 80523, USA.
authors.forename: S D
authors.initials: SD
authors.lastname: Owens
authors.forename: P W
authors.initials: PW
authors.lastname: Gasper
mesh_terms: D000163:Acquired Immunodeficiency Syndrome / Q000503:physiopathology / Q000628:therapy*; D000818:Animals; D005075:Biological Evolution; D005334:Fever / Q000503:physiopathology*; D006678:HIV / Q000254:growth & development / Q000472:pathogenicity / Q000502:physiology*; D015658:HIV Infections / Q000503:physiopathology / Q000628:therapy*; D006801:Humans; D006979:Hyperthermia, Induced; D008954:Models, Biological; D009369:Neoplasms / Q000628:therapy; D009374:Neoplasms, Experimental / Q000628:therapy; D012192:Retroviridae Infections / Q000503:physiopathology / Q000628:therapy