[Phototoxicity and photoallergenicity tests of T-3761].
Phototoxicity and photoallergenicity tests of T-3761 (oral or percutaneous administration) were carried out in guinea pigs. Phototoxicity test of T-3761 (oral administration) was done in rats, too. The following results were obtained. 1. Compared with comparative drugs in oral administration, phototoxicity of T-3761 was equal to that of ciprofloxacin, slightly stronger than that of nalidixic acid and weaker than those of ofloxacin, enoxacin, sparfloxacin and lomefloxacin. 2. A sensibility to phototoxicity of T-3761 in rats was weaker than that in guinea pigs. 3. Phototoxicity and photoallergenicity were not observed in application of T-3761 as 10% ointment. 4. Photoallergenicity was not observed in oral administration of T-3761.
Shibata
T
T
Research Laboratories, Toyama Chemical Co., Ltd., Japan.
Nagasawa
M
M
Iwai
N
N
Miyazaki
M
M
Kawamura
Y
Y
Kodama
T
T
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000633:toxicity*; D017454:Dermatitis, Photoallergic; D017484:Dermatitis, Phototoxic; D005260:Female; D024841:Fluoroquinolones; D006168:Guinea Pigs; D010078:Oxazines / Q000008:administration & dosage / Q000633:toxicity*; D051381:Rats; D017207:Rats, Sprague-Dawley
D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010078:Oxazines; C078052:pazufloxacin