[The protective effects of drugs H and X on liver cold ischemic injury].
Using isolated perfusion rat liver model (IPRL), we studied the protective effects of drugs H and X on rat's liver cold ischemic injury. After the rat's liver was preserved for 12 hours in Collins II solution with the addition of drugs H and X, the necrotic rate of sinusoidal lining cells was significantly lower than that of control group. Within certain range of the dosage of drugs H and X, the necrotic rate of sinusoidal lining cells was in the inverse ratio of the dosage in the Collins II solution. We also found that drugs H and X had obvious protective effect on liver cell redox function. But these drugs could not inhibit tissue from swelling after Collins II solution preservation. The protective mechanisms of the drugs maybe relate to the remoral of free radicals and suppression of Kupffer's cells activity.
Zhang
R
R
Shen
W
W
Wu
Y
Y
Wu
H
H
D000818:Animals; D002121:Calcium Channel Blockers / Q000494:pharmacology*; D003080:Cold Temperature; D004727:Endothelium / Q000166:cytology; D005260:Female; D016166:Free Radical Scavengers / Q000494:pharmacology*; D007657:Ketone Bodies / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000378:metabolism; D008297:Male; D009926:Organ Preservation / Q000379:methods; D010084:Oxidation-Reduction / Q000187:drug effects; D051381:Rats; D017208:Rats, Wistar; D015427:Reperfusion Injury / Q000517:prevention & control*
D002121:Calcium Channel Blockers; D016166:Free Radical Scavengers; D007657:Ketone Bodies