title: Sertraline for social phobia: a double-blind, placebo-controlled crossover study.
abstract: OBJECTIVE
  The authors examined the efficacy of sertraline in the treatment of social phobia.
  
  
  METHODS
  In a double-blind crossover study, 12 outpatients were randomly assigned to 10 weeks of sertraline (50-200 mg/day, flexible dosing) and 10 weeks of placebo.
  
  
  RESULTS
  A statistically significant improvement in scores on the Liebowitz Social Anxiety Scale was found with sertraline but not with placebo. There was no significant difference between scores obtained with computer- and clinician-administered versions of the Liebowitz Social Anxiety Scale, and the majority of patients preferred to be interviewed by the computer.
  
  
  CONCLUSIONS
  Sertraline seems a safe and effective treatment for social phobia, and computer administration may be a preferable mode of assessment with socially phobic patients.
authors.affiliation: Foundation for Health, Research and Education, Madison, WI 53717, USA.
authors.forename: D J
authors.initials: DJ
authors.lastname: Katzelnick
authors.forename: K A
authors.initials: KA
authors.lastname: Kobak
authors.forename: J H
authors.initials: JH
authors.lastname: Greist
authors.forename: J W
authors.initials: JW
authors.lastname: Jefferson
authors.forename: J M
authors.initials: JM
authors.lastname: Mantle
authors.forename: R C
authors.initials: RC
authors.lastname: Serlin
mesh_terms: D015057:1-Naphthylamine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D018592:Cross-Over Studies; D003936:Diagnosis, Computer-Assisted; D004311:Double-Blind Method; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010698:Phobic Disorders / Q000175:diagnosis / Q000188:drug therapy* / Q000523:psychology; D010919:Placebos; D011569:Psychiatric Status Rating Scales / Q000706:statistics & numerical data; D017367:Selective Serotonin Reuptake Inhibitors / Q000627:therapeutic use*; D020280:Sertraline; D012720:Severity of Illness Index; D016896:Treatment Outcome
chemical_list: D015057:1-Naphthylamine; D010919:Placebos; D017367:Selective Serotonin Reuptake Inhibitors; D020280:Sertraline