[Intrapleural DDP and systemic thiosulfate rescue in the treatment of malignant pleural effusion].
One hundred twenty cases of malignant pleural effusion were treated by intrapleural administration of large doses of DDP (500-1,000 mg) followed by iv infusion of sodium thiosulfate for 3 days. Each patient received 1-4 cycles of treatment. Of 120 cases, 89 had their effusion completely disappeared and in 6 of them, it was accompanied by complete regression of tumors in the lung. Partial response was observed in 19 cases with an overall response rate of 90.0%. The median remission period was 6.4 month. Severe (grade III and IV) gastrointestinal, renal toxicity and myelosuppression occurred in 46,8 and 12 cases, respectively, Two patients died of severe intoxication.
Hua
X
X
Department of Thoracic Surgery, Jilin Provincial Cancer Hospital, Changchun.
Lu
W
W
Duan
G
G
D000230:Adenocarcinoma / Q000150:complications; D000328:Adult; D000368:Aged; D000931:Antidotes / Q000008:administration & dosage; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D002294:Carcinoma, Squamous Cell / Q000150:complications; D002945:Cisplatin / Q000008:administration & dosage; D005260:Female; D006801:Humans; D008175:Lung Neoplasms / Q000150:complications*; D008297:Male; D008875:Middle Aged; D016066:Pleural Effusion, Malignant / Q000188:drug therapy*; D013885:Thiosulfates / Q000008:administration & dosage
D000931:Antidotes; D013885:Thiosulfates; C017717:sodium thiosulfate; D002945:Cisplatin