title: Epirubicin and medroxyprogesterone acetate versus estramustine phosphate in hormone-resistant prostatic cancer: a prospective randomized study.
abstract: The effect of a medroxyprogesterone acetate (MPA) plus epirubicin combination versus estramustine phosphate was evaluated in 149 prospectively randomized patients with hormone-resistant prostatic cancer. The estimated probability of being free from progression after 1 year was 17% for the patients treated with estramustine and 29% for the MPA-epirubicin group. There is a significant difference between the two groups regarding risk of progression (p = 0.013). However, no difference in survival was recorded (p > 0.30) with about 60% of the patients dead during the first year in both groups. Progression was highly correlated to sedimentation rate (p < 0.001) and to performance index (p = 0.002). Heart failure occurred in a substantial number of patients in both groups which must be considered before starting therapy.
authors.affiliation: Department of Urology, Kärnsjukhuset, Skövde, Sweden.
authors.forename: C
authors.initials: C
authors.lastname: Anderström
authors.forename: A
authors.initials: A
authors.lastname: Eddeland
authors.forename: P
authors.initials: P
authors.lastname: Folmerz
authors.forename: R
authors.initials: R
authors.lastname: Hansson
authors.forename: S
authors.initials: S
authors.lastname: Milles
authors.forename: B
authors.initials: B
authors.lastname: Zachrisson
mesh_terms: D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000008:administration & dosage / Q000009:adverse effects / Q000627:therapeutic use*; D015251:Epirubicin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D004961:Estramustine / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D006333:Heart Failure / Q000209:etiology; D006801:Humans; D008297:Male; D017258:Medroxyprogesterone Acetate / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D011446:Prospective Studies; D011471:Prostatic Neoplasms / Q000188:drug therapy* / Q000401:mortality; D012008:Recurrence
chemical_list: D004961:Estramustine; D015251:Epirubicin; D017258:Medroxyprogesterone Acetate