[Acute toxicity of liver targeting mitoxantrone-nanospheres].
The experimental result of acute toxicity of liver targeted drug delivery system-mitoxantrone-polybutylcyanoacrylate-nanospheres (DHAQ-PBCA-NS) in mice is reported. The results showed that the acute toxicity of DHAQ-PBCA-NS i.v. in mice was lower than that of DHAQ (LD50 = 16.9 +/- 3.9 mg/kg). The cells of the heart, liver, spleen, kidney and lung had no pathological change. It has been shown that mitoxantrone-nanospheres have some value of application.
Zhang
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Liao
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D000818:Animals; D016503:Drug Delivery Systems; D004659:Enbucrilate; D005260:Female; D007928:Lethal Dose 50; D008099:Liver / Q000187:drug effects* / Q000648:ultrastructure; D008297:Male; D051379:Mice; D008863:Microspheres; D008942:Mitoxantrone / Q000008:administration & dosage / Q000633:toxicity*
D008942:Mitoxantrone; D004659:Enbucrilate