title: Ability of m-chloroperoxybenzoic acid to induce the ornithine decarboxylase marker of skin tumor promotion and inhibition of this response by gallotannins, oligomeric proanthocyanidins, and their monomeric units in mouse epidermis in vivo.
abstract: m-Chloroperoxybenzoic acid (CPBA) was tested for its ability to induce the ornithine decarboxylase (ODC) marker of skin tumor promotion. In contrast to benzoyl peroxide, dicumyl peroxide, and 2-butanol peroxide, 5 mg of CPBA applied twice at a 72-h interval induce ODC activity at least as much as 3 micrograms of 12-O-tetradecanoylphorbol-13-acetate (TPA). ODC induction peaks 36 h after a single CPBA treatment but is maximal 5 h after two applications of CPBA at a 48-h interval. The ODC-inducing activity of CPBA is dose dependent and sustained after chronic treatment. In contrast to TPA, two CPBA treatments at 12-24 h intervals produce no refractory state against ODC induction. The mechanism of ODC induction by CPBA is iron dependent. Various hydrolyzable tannins, condensed tannins (CTs) and their monomeric units remarkably inhibit the ODC response to multiple CPBA treatments. At 12 mg, gallic acid, Aleppo gall tannic acid (TA), catechin, and loblolly pine bark CT inhibit the most CPBA-induced ODC activity. Aleppo gall TA is even effective when applied several hours before CPBA. The tumor-promoting activity of CPBA and its inhibition by plant tannins remain to be evaluated.
authors.affiliation: Anti-Cancer Drug Laboratory, Kansas State University, Manhattan 66506-4901, USA.
authors.forename: G
authors.initials: G
authors.lastname: Chen
authors.forename: E M
authors.initials: EM
authors.lastname: Perchellet
authors.forename: X M
authors.initials: XM
authors.lastname: Gao
authors.forename: S W
authors.initials: SW
authors.lastname: Newell
authors.forename: R W
authors.initials: RW
authors.lastname: Hemingway
authors.forename: V
authors.initials: V
authors.lastname: Bottari
authors.forename: J P
authors.initials: JP
authors.lastname: Perchellet
mesh_terms: D000818:Animals; D000872:Anthocyanins / Q000494:pharmacology*; D002723:Chlorobenzoates / Q000633:toxicity*; D004790:Enzyme Induction / Q000187:drug effects; D005260:Female; D047348:Hydrolyzable Tannins / Q000494:pharmacology*; D051379:Mice; D009955:Ornithine Decarboxylase / Q000096:biosynthesis*; D044945:Proanthocyanidins; D012867:Skin / Q000201:enzymology; D012878:Skin Neoplasms / Q000139:chemically induced* / Q000201:enzymology / Q000517:prevention & control; D013755:Tetradecanoylphorbol Acetate / Q000633:toxicity
chemical_list: D000872:Anthocyanins; D002723:Chlorobenzoates; D047348:Hydrolyzable Tannins; D044945:Proanthocyanidins; C013221:proanthocyanidin; D009955:Ornithine Decarboxylase; C000433:3-chloroperbenzoic acid; D013755:Tetradecanoylphorbol Acetate