title: The effect of tenoxicam on tolbutamide pharmacokinetics and glucose concentrations in healthy volunteers.
abstract: There was no significant difference in the pharmacokinetic parameters of tolbutamide (500 mg) determined before and after 14 days treatment with tenoxicam (20 mg/day) in 7 healthy volunteers (6 male, 1 female). In addition, co-administration of tenoxicam did not alter blood glucose concentrations.
authors.affiliation: Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital Sydney, Australia.
authors.forename: R O
authors.initials: RO
authors.lastname: Day
authors.forename: G
authors.initials: G
authors.lastname: Geisslinger
authors.forename: P
authors.initials: P
authors.lastname: Paull
authors.forename: K M
authors.initials: KM
authors.lastname: Williams
mesh_terms: D000328:Adult; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003198:Computer Simulation; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010894:Piroxicam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D014044:Tolbutamide / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D001786:Blood Glucose; D010894:Piroxicam; D014044:Tolbutamide; C032801:tenoxicam