[The change of polymorphonuclear elastase releasing from ischemic skeleton muscles after reperfusion].
This report evaluates the activity of Polymorphonuclear Elastase (PMNE), after reperfusion of the skeleton muscles during the infra-renal abdominal aortic aneurysmal surgery. We studied the following data to prevent post-operative complications of acute arterial occlusion: the change of PMNE and alpha 1-AT and the effect of Ulinastatin (U)-the inhibitor of PMNE. Twenty surgical cases of the abdominal aortic aneurysms were used in the study. Ten cases of non-U-treated served as group I, 10 cases of U-treated served as group II. PMNE level, in group I, showed a value of 233.7 +/- 34.8 micrograms/l pre-clump and 848.0 +/- 110.3 micrograms/l after releasing the clamp 2 hours later (p < 0.001). In group II, pre-clamping value was 204.8 +/- 21.0 and a relative low value of PMNE (416.7 +/- 36.6 micrograms/l) 2 hours later after releasing the clamp compared with group I. In group I, consistently positive correlations were found between the duration of clamping time and the value of PMNE. This study shows that PMNE increases statistically after re-perfusion of the skeleton muscle. U shows a significant inhibition of PMNE increasing. U may prevent further damages of the visceral organs after operation of acute arterial occlusion.
Inazawa
K
K
Second Department of Surgery, Yamagata University, School of Medicine, Japan.
D000368:Aged; D017544:Aortic Aneurysm, Abdominal / Q000601:surgery; D001157:Arterial Occlusive Diseases / Q000517:prevention & control; D006023:Glycoproteins / Q000627:therapeutic use; D006801:Humans; D019272:Leukocyte Elastase; D008297:Male; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000098:blood supply*; D009504:Neutrophils / Q000201:enzymology*; D010196:Pancreatic Elastase / Q000037:antagonists & inhibitors / Q000097:blood*; D011183:Postoperative Complications / Q000517:prevention & control; D015427:Reperfusion Injury / Q000097:blood / Q000201:enzymology*; D014361:Trypsin Inhibitors / Q000627:therapeutic use; D000515:alpha 1-Antitrypsin / Q000378:metabolism
D006023:Glycoproteins; D014361:Trypsin Inhibitors; D000515:alpha 1-Antitrypsin; D010196:Pancreatic Elastase; D019272:Leukocyte Elastase; C028665:urinastatin