Provocation of porphyria cutanea tarda by KUVA-therapy of vitiligo.
Therapy with khellin and UVA irradiation (KUVA) is a therapeutic approach to vitiligo. Little is known about the photobiological properties of khellin and its long-term side-effects after prolonged administration. A 47-year-old woman suffering from acral vitiligo since the age of 3 is reported, who developed blisters on hands and fingers during KUVA-therapy. Laboratory findings were consistent with hereditary porphyria cutanea tarda. Electron microscopic examination of a blister revealed clefting below the basement membrane. It is proposed that khellin in some way provoked the porphyria cutanea tarda in this patient.
Jansen
T
T
Department of Dermatology, Ludwig-Maximilians-University, Munich, Germany.
Megahed
M
M
Hölzle
E
E
Plewig
G
G
D001485:Basement Membrane / Q000187:drug effects / Q000473:pathology; D001768:Blister / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006229:Hand Dermatoses / Q000188:drug therapy*; D006801:Humans; D007666:Khellin / Q000009:adverse effects*; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects*; D017119:Porphyria Cutanea Tarda / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology; D014820:Vitiligo / Q000188:drug therapy*
D007666:Khellin