Development and evaluation of a buccoadhesive propranolol tablet formulation.
Buccoadhesive tablets were prepared by directly compressing propranolol with poly(acrylic)acid (PAA), hydroxypropylmethylcellulose (HPMC) and hydroxypropylcellulose (HPC) in different ratios. The release data were fitted to Mt/M infinity = ktn simple equation. The release characteristics has shown a non-Fickian mechanism of release. The best kinetic fit were zero order and slab erosion kinetic. The detachment force between buccoadhesive tablets and bovine buccal mucosa was carried out by the tensile tester apparatus. The high amount of PAA containing formulation demonstrated the greatest adhesive force.
Celebi
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N
Department of Pharmaceutical Technology, Gazi Univeristy, Ankara, Turkey.
Kişlal
O
O
D000180:Acrylic Resins; D000268:Adhesiveness; D000818:Animals; D000924:Anticholesteremic Agents; D000970:Antineoplastic Agents; D002417:Cattle; D002478:Cells, Cultured; D002482:Cellulose / Q000031:analogs & derivatives; D065347:Hypromellose Derivatives; D007700:Kinetics; D008747:Methylcellulose / Q000031:analogs & derivatives; D009061:Mouth Mucosa / Q000378:metabolism; D011433:Propranolol / Q000008:administration & dosage* / Q000493:pharmacokinetics; D013607:Tablets
D000180:Acrylic Resins; D000924:Anticholesteremic Agents; D000970:Antineoplastic Agents; D013607:Tablets; D065347:Hypromellose Derivatives; C006903:carbopol 940; D002482:Cellulose; D008747:Methylcellulose; C008079:hydroxypropylcellulose; D011433:Propranolol