title: A study of Toxoplasma and Cytomegalovirus serology in tuberculosis and in HIV-infected patients in Burkina Faso.
abstract: Seroreactivity to Toxoplasma gondii (Tg) and to Cytomegalovirus (Cmv) was compared between symptomatic HIV-infected patients (40 with pulmonary tuberculosis and 38 with AIDS) and HIV-seronegative patients (40 tuberculosis patients and 30 healthy patients), in an urban area of Burkina Faso. Prevalence of IgG antibodies to Tg antigens (> 50.0%) did not differ amongst the four groups, but tuberculosis HIV+ patients and AIDS patients showed more higher titers of Tg antibodies more often than healthy patients (p < 0.05 and p < 0.005, respectively). Prevalence of specific IgG to Cmv was higher in tuberculosis HIV-seronegative patients (97.5%) and in AIDS patients (100%) than in healthy patients (82%; p < 0.03 and p < 0.001, respectively). Higher Cmv antibodies titers were found in relation to AIDS but also to tuberculosis. Tuberculosis HIV+ as tuberculosis HIV-patients showed higher Cmv antibodies titers than healthy patients (p < 0.002 and < 0.02 respectively). These data emphasize the need for taking into account the risk of Tg reactivation during the follow-up of HIV infected patients in Burkina Faso and suggest possible relationships between Cmv and tuberculosis reactivations.
authors.affiliation: Centre Muraz (Organisation de Coordination et de Coopération pour la Lutte contre les Grandes Endémies, Bobo-Dioulasso, Burkina Faso.
authors.forename: E
authors.initials: E
authors.lastname: Ledru
authors.forename: S
authors.initials: S
authors.lastname: Diagbouga
authors.forename: S
authors.initials: S
authors.lastname: Ledru
authors.forename: B
authors.initials: B
authors.lastname: Cauchoix
authors.forename: M
authors.initials: M
authors.lastname: Yameogo
authors.forename: D
authors.initials: D
authors.lastname: Chami
authors.forename: O
authors.initials: O
authors.lastname: Sanou
authors.forename: J P
authors.initials: JP
authors.lastname: Chiron
mesh_terms: D017088:AIDS-Related Opportunistic Infections / Q000276:immunology*; D000328:Adult; D000818:Animals; D000913:Antibodies, Protozoan / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D002050:Burkina Faso; D003587:Cytomegalovirus / Q000276:immunology*; D005260:Female; D015483:HIV Antibodies / Q000097:blood; D015497:HIV-1 / Q000276:immunology; D015498:HIV-2 / Q000276:immunology; D006801:Humans; D008297:Male; D008875:Middle Aged; D014122:Toxoplasma / Q000276:immunology*; D014397:Tuberculosis, Pulmonary / Q000276:immunology*
chemical_list: D000913:Antibodies, Protozoan; D000914:Antibodies, Viral; D015483:HIV Antibodies