The effect of tenoxicam on tolbutamide pharmacokinetics and glucose concentrations in healthy volunteers.
There was no significant difference in the pharmacokinetic parameters of tolbutamide (500 mg) determined before and after 14 days treatment with tenoxicam (20 mg/day) in 7 healthy volunteers (6 male, 1 female). In addition, co-administration of tenoxicam did not alter blood glucose concentrations.
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Department of Clinical Pharmacology and Toxicology, St. Vincent's Hospital Sydney, Australia.
Geisslinger
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Paull
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Williams
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KM
D000328:Adult; D000704:Analysis of Variance; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000008:administration & dosage / Q000494:pharmacology*; D001786:Blood Glucose / Q000378:metabolism*; D002851:Chromatography, High Pressure Liquid; D003198:Computer Simulation; D004347:Drug Interactions; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010894:Piroxicam / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D014044:Tolbutamide / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*
D000894:Anti-Inflammatory Agents, Non-Steroidal; D001786:Blood Glucose; D010894:Piroxicam; D014044:Tolbutamide; C032801:tenoxicam