Low molecular weight immunomodulators produced by microorganisms.
In order to develop a new class of low molecular weight immunomodulators for the treatment of incurable diseases involving cancer, hematologic diseases and inflammation, we have sought cytokine inducers and inhibitors of cell adhesion to the extracellular matrix among the low molecular compounds produced by microorganisms. Cytogenin, cytoblastin (a monokine inducer), conagenin (a lymphokine inducer) and delaminomycins and IC-101 (inhibitors of cell adhesion to extracellular matrices) have been recently found in our institute. In this report, we describe the principles of screening and structures, and discuss their biological activities.
Ishizuka
M
M
Institute for Chemotherapy, Microbial Chemistry Research Foundation, Shizuoka, Japan.
Kawatsu
M
M
Yamashita
T
T
Ueno
M
M
Takeuchi
T
T
D039903:Actinobacteria / Q000378:metabolism*; D000276:Adjuvants, Immunologic / Q000737:chemistry* / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000737:chemistry / Q000494:pharmacology; D000903:Antibiotics, Antineoplastic / Q000737:chemistry / Q000494:pharmacology; D001685:Biological Factors / Q000737:chemistry / Q000494:pharmacology*; D002448:Cell Adhesion / Q000187:drug effects; D003374:Coumarins / Q000737:chemistry / Q000494:pharmacology; D016207:Cytokines / Q000096:biosynthesis; D004354:Drug Screening Assays, Antitumor; D005109:Extracellular Matrix / Q000378:metabolism; D006410:Hematopoiesis; D007166:Immunosuppressive Agents / Q000737:chemistry / Q000494:pharmacology; D007211:Indoles / Q000737:chemistry / Q000494:pharmacology; D049934:Isocoumarins; D007769:Lactams / Q000737:chemistry / Q000494:pharmacology; D051379:Mice; D010455:Peptides; D011760:Pyrrolidinones / Q000737:chemistry / Q000494:pharmacology; D012694:Serine / Q000031:analogs & derivatives / Q000737:chemistry / Q000494:pharmacology; D013601:T-Lymphocytes / Q000166:cytology / Q000378:metabolism; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000494:pharmacology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D000900:Anti-Bacterial Agents; D000903:Antibiotics, Antineoplastic; D001685:Biological Factors; D003374:Coumarins; D016207:Cytokines; D007166:Immunosuppressive Agents; D007211:Indoles; D049934:Isocoumarins; D007769:Lactams; D010455:Peptides; D011760:Pyrrolidinones; D013764:Tetrahydronaphthalenes; C066806:cytogenin; C069645:conagenin; C071412:cytoblastin; C082438:delaminomycin A; C082440:delaminomycin B; C082441:delaminomycin C; C085032:IC 101; D012694:Serine