title: Effects of different types of isocaloric parenteral nutrients on food intake and metabolic concomitants.
abstract: Whether spontaneous food intake (SFI) is controlled by infused nutrient type or its caloric content, irrespective of nutrient type, was investigated. Rats were infused for 4 days with isocaloric solutions of different nutrient type but sharing the same intermediary metabolic oxidative pathway, providing 25% of daily caloric needs. One parenteral solution was a glucose, fat and amino acid mix (TPN-25%); the other provided ketone bodies (TRI-3.5%). Effects of parenteral infusions on SFI and metabolic concomitants were compared and contrasted to that in a group of orally fed rats. Both infusions reduced SFT by 50%. Rats receiving TRI-3.5% had lower blood glucose and insulin concentrations, but increased hepatic glycogen content compared to TPN-25% or orally fed rats. No differences in hepatic triglycerides occurred between the three groups. However, serum free fatty acids were significantly lower in TRI-3.5% and in TPN-25% groups vs. fed rats. Data indicate food intake suppression is mediated by caloric content rather than nutrient type, suggesting that a mediator of SFI regulation could be at the citric acid cycle level.
authors.affiliation: Department of Surgery, University Hospital, SUNY Health Science Center, Syracuse, NY 13210, USA.
authors.forename: G
authors.initials: G
authors.lastname: Bodoky
authors.forename: M M
authors.initials: MM
authors.lastname: Meguid
authors.forename: Z J
authors.initials: ZJ
authors.lastname: Yang
authors.forename: A
authors.initials: A
authors.lastname: Laviano
mesh_terms: D000596:Amino Acids / Q000008:administration & dosage; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D002952:Citric Acid Cycle / Q000502:physiology; D004435:Eating / Q000502:physiology*; D002149:Energy Intake / Q000502:physiology*; D004734:Energy Metabolism / Q000502:physiology*; D005217:Fat Emulsions, Intravenous / Q000008:administration & dosage; D005230:Fatty Acids, Nonesterified / Q000097:blood; D005950:Glucose Solution, Hypertonic / Q000008:administration & dosage; D007328:Insulin / Q000097:blood; D007657:Ketone Bodies / Q000008:administration & dosage / Q000097:blood; D008112:Liver Glycogen / Q000378:metabolism; D008297:Male; D010289:Parenteral Nutrition, Total; D051381:Rats; D011916:Rats, Inbred F344; D012528:Satiety Response / Q000502:physiology*; D014280:Triglycerides / Q000008:administration & dosage / Q000097:blood
chemical_list: D000596:Amino Acids; D001786:Blood Glucose; D005217:Fat Emulsions, Intravenous; D005230:Fatty Acids, Nonesterified; D005950:Glucose Solution, Hypertonic; D007328:Insulin; D007657:Ketone Bodies; D008112:Liver Glycogen; D014280:Triglycerides