title: The mechanism of blood pressure variability. Study in patients with fixed ventricular pacemaker rhythm.
abstract: BACKGROUND
  Several studies have shown that heart rate variability plays an anti-oscillatory role in the regulation of blood pressure variability in humans. We tested whether systolic blood pressure variability in patients with a fixed ventricular pacemaker rhythm differs from that in patients with sinus rhythm.
  
  
  RESULTS
  In 18 patients with a fixed ventricular pacemaker rhythm and in ten age-matched patients with sinus rhythm the systolic blood pressure oscillation and the low and high-frequency spectral components of systolic blood pressure were studied in the resting supine position during spontaneous breathing and during forced deep ventilation of 6 cycles.min-1. Patients with a pacemaker had a higher amplitude of systolic blood pressure oscillation than control subjects during spontaneous breathing (13.5 +/- 2.0 mmHg vs 6.4 +/- 1.6 mmHg, P = 0.035), and a slight but not significant difference also persisted during forced deep ventilation 19.0 +/- 2.3 mmHg vs 15.0 +/- 2.3 mmHg, P = 0.18). The increment in systolic blood pressure fluctuation from spontaneous breathing to forced deep ventilation was less marked in the pacemaker group than in the control subjects (40% vs 130%, P = 0.43). Although all the systolic blood pressure spectral components of the pacemaker patients were higher during both spontaneous breathing and forced deep ventilation, the differences between the two groups did not reach statistical significance.
  
  
  CONCLUSIONS
  Our observations in patients with a fixed ventricular pacemaker rhythm suggest that the mechanical effects on the intrathoracic vessels and the consecutive stroke volume changes are responsible for respiration-related systolic blood pressure oscillation and reflex systolic blood pressure changes.
authors.affiliation: Second Department of Medicine, Albert Szent-Györgyi Medical University, Szeged, Hungary.
authors.forename: A
authors.initials: A
authors.lastname: Kardos
authors.forename: L
authors.initials: L
authors.lastname: Rudas
authors.forename: Z
authors.initials: Z
authors.lastname: Gingl
authors.forename: S
authors.initials: S
authors.lastname: Szabados
authors.forename: J
authors.initials: J
authors.lastname: Simon
mesh_terms: D000368:Aged; D000704:Analysis of Variance; D001794:Blood Pressure / Q000502:physiology*; D003201:Computers; D004562:Electrocardiography; D006339:Heart Rate / Q000502:physiology; D006801:Humans; D010138:Pacemaker, Artificial; D010991:Plethysmography; D011187:Posture; D012119:Respiration / Q000502:physiology*; D018754:Ventricular Dysfunction / Q000628:therapy