Role of the striatal cholinergic system in the regulation of learned manipulation in rats.
The experiments were performed on adult Wistar male rats trained to push with the forepaw on a fixed piston inside a narrow tube. It was found that after localized intracerebral injection of a cholinergic antagonist into the dorso-lateral (but not medial) neostriatum (i.e., the caudato-putamen) the behavioral performance requiring brief innate movements remained unchanged, but the performance requiring a prolonged pushing movement (> 50 msec) became disrupted. Micoinjection of carbacholine (0.03-3 mu g/l microliters) did not affect the performance of the acquired movements, whereas scopolamine (3 mu g/l microliters) led to the significant decrease in pushing time. We conclude that changes in the state of the dorso-lateral neostriatal cholinergic system result only in disturbances of the sensory-controlled component of a complex instrumental movement.
Dubrovskaya
N M
NM
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences.
Zhuravin
I A
IA
D000818:Animals; D002217:Carbachol / Q000008:administration & dosage / Q000494:pharmacology; D003216:Conditioning, Operant / Q000187:drug effects / Q000502:physiology*; D007267:Injections; D008297:Male; D009068:Movement / Q000187:drug effects; D017072:Neostriatum / Q000187:drug effects / Q000502:physiology*; D010275:Parasympathetic Nervous System / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D012601:Scopolamine / Q000008:administration & dosage / Q000494:pharmacology
D002217:Carbachol; D012601:Scopolamine