Familial acanthosis nigricans with madarosis.
We report familial acanthosis nigricans affecting a 35-year-old woman, her 7-year-old son and 5-year-old daughter. Absence of the eyebrows and eyelashes was noted in this family. The mother had no axillary hair and her pubic hair was sparse. The boy also suffered from congenital heart disease and a congenital cataract in the left eye. The combination of acanthosis nigricans and ectodermal defects in this family may represent a distinct nosological entity.
Chuang
S D
SD
Department of Dermatology, National Taiwan University Hospital, Taipei, Republic of China.
Jee
S H
SH
Chiu
H C
HC
Chen
J S
JS
Lin
J T
JT
D000052:Acanthosis Nigricans / Q000150:complications* / Q000473:pathology; D000328:Adult; D002386:Cataract / Q000150:complications / Q000151:congenital; D002648:Child; D002675:Child, Preschool; D005149:Facial Expression; D005192:Family Health; D005260:Female; D006201:Hair Diseases / Q000150:complications* / Q000473:pathology; D006345:Heart Septal Defects, Ventricular / Q000150:complications; D006801:Humans; D008297:Male; D013577:Syndrome