Comparison of the pressor effects of angiotensin II and III in the rostral ventrolateral medulla.
Microinjection of angiotensin II and III into the rostral ventrolateral medulla of anesthetized barodenervated rabbits elicited in both cases pressor responses, which were of similar magnitude and time course. The responses to angiotensin II and III were either unchanged or increased in the presence of compounds which inhibit their degradation to shorter length peptides. The results indicate that both angiotensin peptides are independently capable of eliciting pressor responses in the rostral ventrolateral medulla.
Sasaki
S
S
Department of Physiology, University of Sydney, NSW Australia.
Li
Y W
YW
Dampney
R A
RA
D000804:Angiotensin II / Q000008:administration & dosage / Q000494:pharmacology*; D000805:Angiotensin III / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D000900:Anti-Bacterial Agents / Q000494:pharmacology; D001794:Blood Pressure / Q000187:drug effects*; D006651:Histocytochemistry; D006735:Horseradish Peroxidase; D007930:Leucine / Q000031:analogs & derivatives / Q000494:pharmacology; D008526:Medulla Oblongata / Q000033:anatomy & histology / Q000502:physiology*; D008845:Microinjections; D009842:Oligopeptides / Q000494:pharmacology; D010455:Peptides; D011817:Rabbits; D012964:Sodium / Q000008:administration & dosage / Q000494:pharmacology; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins
D000900:Anti-Bacterial Agents; D009842:Oligopeptides; D010455:Peptides; D018998:Wheat Germ Agglutinin-Horseradish Peroxidase Conjugate; D014909:Wheat Germ Agglutinins; D000804:Angiotensin II; D000805:Angiotensin III; C016977:amastatin; D012964:Sodium; D006735:Horseradish Peroxidase; D007930:Leucine; C012211:ubenimex