Protective effect of dietary fructo-oligosaccharide in young rats against exocrine pancreas atrophy induced by high fructose and partial copper deficiency.
The objective of this investigation was to protect rats against exocrine pancreatic atrophy by adding 22% fructo-oligosaccharide (FOS), a natural fructan obtained from inulin, to the 50% copper-deficient diets containing qualitatively and quantitatively different carbohydrates. Young male Wistar rats were maintained on these diets for 10 wk, being weighed weekly then killed and autopsied. Major organs were weighed and histologically examined. Copper content in the diets was measured by flame atomic absorption spectroscopy. Incomplete (50%) copper deficiency avoided precocious mortality due to cardiovascular lesions and enabled another pathological condition to develop, consisting of the induction of exocrine pancreas atrophy. Introduction of gradually increasing percentages of fructose in diets at the level of 22, 42 and 62% induced a gradual increase in the copper-deficiency-mediated pathology in rats, expressed by an increase in exocrine pancreatic atrophy. 22% FOS introduced to the diet prevented the pathology induced by both fructose and partial copper deficiency better than starch added to diet at the level of 20 or 40%.
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Départment des Sciences Pharmaceutiques, Université Catholique de Louvain, Brussels, Belgium.
Delzenne
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N
Tshilombo
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A
Roberfroid
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M
D000818:Animals; D001284:Atrophy / Q000209:etiology / Q000517:prevention & control; D001835:Body Weight; D006332:Cardiomegaly / Q000209:etiology; D003300:Copper / Q000032:analysis / Q000172:deficiency*; D004032:Diet; D004040:Dietary Carbohydrates / Q000008:administration & dosage*; D005630:Fructans / Q000008:administration & dosage*; D005632:Fructose / Q000008:administration & dosage* / Q000009:adverse effects; D008099:Liver / Q000737:chemistry; D008297:Male; D009929:Organ Size; D010179:Pancreas / Q000473:pathology*; D051381:Rats; D017208:Rats, Wistar; D013054:Spectrophotometry, Atomic
D004040:Dietary Carbohydrates; D005630:Fructans; D005632:Fructose; D003300:Copper