title: [Development of biochemical and histopathological parameters in paracetamol overdose in experimental cholestasis].
abstract: The aim of the present paper is to determine the effect of Paracetamol (P) acute intoxication in cholestatic rats. Four groups of animals were considered: controls, controls intoxicated with P, rats intoxicated with P and cholestatic rats. Hepatic biochemical tests and liver histology were performed in every group. It is concluded that cholestatic rats intoxicated with P showed less Liver damage than in control groups.
authors.affiliation: Cátedra de Fisiopatología, Facultad de Farmacia y Bioquímica Universidad de Buenos Aires, Argentina.
authors.forename: G
authors.initials: G
authors.lastname: Ouvińa
authors.forename: J C
authors.initials: JC
authors.lastname: Perazzo
authors.forename: M
authors.initials: M
authors.lastname: Di Carlo
authors.forename: G
authors.initials: G
authors.lastname: Negri
authors.forename: N
authors.initials: N
authors.lastname: Lago
authors.forename: A
authors.initials: A
authors.lastname: Lemberg
authors.forename: L
authors.initials: L
authors.lastname: Bengochea
mesh_terms: D000082:Acetaminophen / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D000208:Acute Disease; D000818:Animals; D001651:Cholestasis, Extrahepatic / Q000139:chemically induced* / Q000201:enzymology; D062787:Drug Overdose; D014453:Glucuronosyltransferase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000082:Acetaminophen; D014453:Glucuronosyltransferase
vernacular_title: Evolución de parámetros bioquímicos e histopatológicos en la sobredosis con paracetamol durante la colestasis experimental.