The amplifying effect of beta-amyloid on cellular calcium signalling is reduced in Alzheimer's disease.
The amplifying effect of beta-amyloid fragment 25-35 (beta A25-35) on the mitogen-induced rise of free intracellular calcium in circulating lymphocytes was strongly reduced in 24 patients with Alzheimer's disease when compared with elderly, non-demented controls. Low beta-amyloid responses were significantly correlated with the presence of the apolipoprotein E epsilon 4 allele, suggesting a dose effect.
Eckert
A
A
Department of Psychopharmacology, Central Institute of Mental Health, Mannheim, Germany.
Förstl
H
H
Hartmann
H
H
Czech
C
C
Mönning
U
U
Beyreuther
K
K
Müller
W E
WE
D000328:Adult; D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D016229:Amyloid beta-Peptides / Q000378:metabolism*; D001057:Apolipoproteins E / Q000378:metabolism; D002118:Calcium / Q000378:metabolism*; D005260:Female; D006801:Humans; D008214:Lymphocytes / Q000378:metabolism; D008297:Male; D008875:Middle Aged; D013997:Time Factors
D016229:Amyloid beta-Peptides; D001057:Apolipoproteins E; D002118:Calcium