title: [Immunohistochemical study of PCNA, EGFR, c-erbB-2 and p53 in carcinomas of large intestine].
abstract: Immunohistochemical stainings for EGFR, c-erbB-2, p53 and PCNA were performed on 36 and 30 cases of intramucosal and advanced carcinomas of large intestine. Positive rate was 58.3%, 41.6%, 58.3% and 60.6% for EGFR, c-erbB-2, p53 and PCNA in the intramucosal cases, and 66.7%, 50%, 66.7% and 72.6% in the advanced ones, respectively. Relationship between EGFR and c-drbB-2 was more significant in the advanced carcinomas than that in the intramucosal ones. It seemed likely that relationship between p53 and c-erbB-2 was more significant than that between p53 and EGFR. Positive rate of PCNA was of intimate relationship among that of EGFR, c-erbB-2 and p53, and the positive rate increased in the advanced carcinomas.
authors.affiliation: Department of Pathology, Mie University Hospital, Tsu.
authors.forename: H
authors.initials: H
authors.lastname: Yamagiwa
authors.forename: N
authors.initials: N
authors.lastname: Onishi
authors.forename: T
authors.initials: T
authors.lastname: Onishi
authors.forename: T
authors.initials: T
authors.lastname: Onishi
authors.forename: H
authors.initials: H
authors.lastname: Onishi
authors.forename: K
authors.initials: K
authors.lastname: Watanabe
authors.forename: Y
authors.initials: Y
authors.lastname: Kadowaki
authors.forename: M
authors.initials: M
authors.lastname: Nishii
authors.forename: Y
authors.initials: Y
authors.lastname: Kato
mesh_terms: D014408:Biomarkers, Tumor / Q000032:analysis*; D002277:Carcinoma / Q000175:diagnosis*; D003110:Colonic Neoplasms / Q000175:diagnosis*; D066246:ErbB Receptors / Q000032:analysis*; D006801:Humans; D007150:Immunohistochemistry; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*; D018719:Erb-b2 Receptor Tyrosine Kinases / Q000032:analysis*; D016159:Tumor Suppressor Protein p53 / Q000032:analysis*
chemical_list: D014408:Biomarkers, Tumor; D066246:ErbB Receptors; D018809:Proliferating Cell Nuclear Antigen; D018719:Erb-b2 Receptor Tyrosine Kinases; D016159:Tumor Suppressor Protein p53