Genetic mapping of the multiple endocrine neoplasia type 1 locus at 11q13.
Oncogenesis of tumours related to multiple endocrine neoplasia type 1 (MEN1) is associated with somatic deletions involving the MEN1 locus at chromosomal region 11q13, suggesting inactivation of a tumour-suppressor gene in this region. Here we describe the localization of the MEN1 gene to a 900-kb region, based on linkage analysis in affected families and deletion mapping of MEN1-associated tumours. In addition, a set of microsatellite markers mapped to the 11q11-13 region were used for linkage analysis in a large Tasmanian MEN1 pedigree, demonstrating the usefulness of these markers for presymptomatic testing in affected families.
Teh
B T
BT
Department of Molecular Medicine, Karolinska Hospital, Stockholm, Sweden.
Cardinal
J
J
Shepherd
J
J
Hayward
N K
NK
Weber
G
G
Cameron
D
D
Larsson
C
C
D000328:Adult; D002872:Chromosome Deletion; D002874:Chromosome Mapping; D002880:Chromosomes, Human, Pair 11 / Q000235:genetics*; D008040:Genetic Linkage; D005838:Genotype; D006579:Heterozygote; D006801:Humans; D008126:Lod Score; D008875:Middle Aged; D018761:Multiple Endocrine Neoplasia Type 1 / Q000235:genetics*; D010375:Pedigree; D013648:Tasmania