title: Physical linkage of the cdc2-related gene (PCTK1) and the ubiquitin-activating enzyme E1 gene (UBE1) on human Xp11.3.
abstract: PCTAIRE-1 is a cdc2-related protein kinase of unknown function. The gene (PCTK1) has been mapped to chromosome Xp. In this study we refine the locus position by chromosome analysis with cosmid and YAC probes. PCTK1 maps distal to the t(X;18) synovial sarcoma breakpoint in Xp11.23. A 420-kb YAC clone positive for PCTK1 also contains the gene coding for ubiquitin-activating enzyme UBE1, previously mapped in Xp11.3, indicating close physical linkage of these genes. PCTK1 is a new candidate for heritable disorders mapped to Xp11.3--p11.23 region.
authors.affiliation: Department of Histopathology, UMDS, St Thomas' Hospital, London, England.
authors.forename: J C
authors.initials: JC
authors.lastname: Knight
authors.forename: P J
authors.initials: PJ
authors.lastname: Renwick
authors.forename: J R
authors.initials: JR
authors.lastname: Downing
authors.forename: T
authors.initials: T
authors.lastname: Okuda
mesh_terms: D001483:Base Sequence; D016203:CDC2 Protein Kinase / Q000235:genetics*; D002874:Chromosome Mapping; D015342:DNA Probes; D008040:Genetic Linkage; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D008025:Ligases / Q000235:genetics*; D008969:Molecular Sequence Data; D016133:Polymerase Chain Reaction; D044764:Ubiquitin-Activating Enzymes; D044767:Ubiquitin-Protein Ligases; D014960:X Chromosome
chemical_list: D015342:DNA Probes; D044767:Ubiquitin-Protein Ligases; D016203:CDC2 Protein Kinase; D008025:Ligases; D044764:Ubiquitin-Activating Enzymes