title: [123I]beta-CIT SPECT imaging of striatal dopamine transporter binding in Tourette's disorder.
abstract: OBJECTIVE
  The authors examined whether subjects with Tourette's disorder have greater than normal striatal dopamine transporter densities, as suggested by previous post-mortem findings.
  
  
  METHODS
  Single photon emission computed tomography (SPECT) and [123I]2 beta-carbomethoxy-3 beta-(4-iodophenyl)tropane ([123I]beta-CIT) were used to assess dopamine transporter levels in five adult patients with Tourette's disorder and five age- and gender-matched healthy comparison subjects.
  
  
  RESULTS
  Striatal [123I]beta-CIT binding was a mean of 37% (range = 6%-79%) higher in the subjects with Tourette's disorder than in the comparison subjects, and each Tourette's disorder patient had a higher level than his or her paired comparison subject.
  
  
  CONCLUSIONS
  These findings corroborate post-mortem results and support the hypothesis of a dysregulation in presynaptic dopamine function in Tourette's disorder.
authors.affiliation: Department of Psychiatry, Yale University School of Medicine, New Haven, Conn., USA.
authors.forename: R T
authors.initials: RT
authors.lastname: Malison
authors.forename: C J
authors.initials: CJ
authors.lastname: McDougle
authors.forename: C H
authors.initials: CH
authors.lastname: van Dyck
authors.forename: L
authors.initials: L
authors.lastname: Scahill
authors.forename: R M
authors.initials: RM
authors.lastname: Baldwin
authors.forename: J P
authors.initials: JP
authors.lastname: Seibyl
authors.forename: L H
authors.initials: LH
authors.lastname: Price
authors.forename: J F
authors.initials: JF
authors.lastname: Leckman
authors.forename: R B
authors.initials: RB
authors.lastname: Innis
mesh_terms: D000328:Adult; D000367:Age Factors; D002352:Carrier Proteins / Q000378:metabolism*; D003042:Cocaine / Q000031:analogs & derivatives*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism*; D004298:Dopamine / Q000378:metabolism* / Q000502:physiology; D050483:Dopamine Plasma Membrane Transport Proteins; D005260:Female; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; D012737:Sex Factors; D015899:Tomography, Emission-Computed, Single-Photon; D005879:Tourette Syndrome / Q000000981:diagnostic imaging / Q000378:metabolism* / Q000503:physiopathology
chemical_list: D002352:Carrier Proteins; D050483:Dopamine Plasma Membrane Transport Proteins; D007457:Iodine Radioisotopes; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C069723:2beta-carbomethoxy-3beta-(4-iodophenyl)tropane; D003042:Cocaine; D004298:Dopamine