title: Serum levels of interleukin-1, interleukin-6 and tumour necrosis factor-alpha in patients with gastric carcinoma.
abstract: The possible role of inflammation-associated cytokines such as interleukin-1 (IL-1), interleukin-6 (IL-6) and tumour necrosis factor-alpha (TNF-alpha) was investigated by measuring the levels of these cytokines in serum samples from 21 patients with advanced gastric carcinoma. These values were compared with those detected in 17 age-matched controls. The levels of IL-1 beta and IL-6 were significantly increased (approximately sixfold) in gastric cancer patients. While there was a modest increase (approximately twofold) in the level of IL-1 alpha, the circulating level of TNF-alpha was greatly reduced (approximately threefold) in the patient group.
authors.affiliation: Department of Surgery, College of Medicine, Sultan Qaboos University, Oman.
authors.forename: S
authors.initials: S
authors.lastname: Kabir
authors.forename: G A
authors.initials: GA
authors.lastname: Daar
mesh_terms: D002277:Carcinoma / Q000097:blood*; D005260:Female; D006801:Humans; D007375:Interleukin-1 / Q000097:blood*; D015850:Interleukin-6 / Q000097:blood*; D008297:Male; D013274:Stomach Neoplasms / Q000097:blood*; D014409:Tumor Necrosis Factor-alpha / Q000378:metabolism*
chemical_list: D007375:Interleukin-1; D015850:Interleukin-6; D014409:Tumor Necrosis Factor-alpha