[The effect of immunoglobulin on hemostatic function in patients with HIV infection].
The influence of immunoglobulin for intravenous injection on the state of cell- and plasma-mediated elements of hemostasis in patients with HIV infection, treated with immunoglobulin (Ig) in connection with the presence of secondary diseases of bacterial nature and having thrombocytopenia, was analyzed. After two injections of 50.0 ml of Ig to patients with HIV infection and thrombocytopenia a rise in the count of blood platelets in 80% of cases; this rise reached its maximum on day 7-10 after the beginning of treatment and was retained 1-3 months later in most patients on the level of healthy persons. Under the influence of Ig the aggregation capacity of thrombocytes increased mainly in persons with the initially low function of blood platelets. The introduction of Ig did not perceptibly influence the capacity of thrombocytes for endo-exocytosis, the aggregation activity of red blood cells, as well as the plasma-mediated element of hemostasis.
Kravchenko
A V
AV
Poliakova
A M
AM
Iurin
O G
OG
Astrina
O S
OS
Serebrovskaia
L V
LV
Pokrovskiĭ
V V
VV
D000328:Adult; D016516:CD4-CD8 Ratio / Q000187:drug effects; D005260:Female; D015658:HIV Infections / Q000097:blood / Q000150:complications / Q000628:therapy*; D015497:HIV-1; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D016756:Immunoglobulins, Intravenous / Q000627:therapeutic use*; D008297:Male; D010976:Platelet Count / Q000187:drug effects; D013921:Thrombocytopenia / Q000097:blood / Q000209:etiology / Q000628:therapy
D016756:Immunoglobulins, Intravenous
Vliianie immunoglobulina na sostoianie gemostaza u bol'nykh VICh-infektsieĭ.