Evaluation of calcineurin's role in the immunosuppressive activity of FK 506, related macrolactams, and cyclosporine.
Lane
B C
BC
Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois 60064-3500.
Miller
L N
LN
Kawai
M
M
Or
Y S
YS
Wiedeman
P
P
Holzman
T F
TF
Luly
J R
JR
D000591:Amino Acid Isomerases / Q000494:pharmacology*; D000595:Amino Acid Sequence; D000900:Anti-Bacterial Agents / Q000494:pharmacology*; D019703:Calcineurin; D002148:Calmodulin-Binding Proteins / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology*; D002352:Carrier Proteins / Q000494:pharmacology*; D016572:Cyclosporine / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007700:Kinetics; D007769:Lactams; D007959:Lymphocyte Culture Test, Mixed; D008214:Lymphocytes / Q000187:drug effects / Q000276:immunology* / Q000378:metabolism; D008969:Molecular Sequence Data; D019696:Peptidylprolyl Isomerase; D010748:Phosphopeptides / Q000138:chemical synthesis / Q000378:metabolism; D010749:Phosphoprotein Phosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism* / Q000502:physiology*; D011993:Recombinant Fusion Proteins / Q000494:pharmacology; D013379:Substrate Specificity; D016559:Tacrolimus / Q000494:pharmacology*; D022021:Tacrolimus Binding Proteins
D000900:Anti-Bacterial Agents; D002148:Calmodulin-Binding Proteins; D002352:Carrier Proteins; D007769:Lactams; D010748:Phosphopeptides; D011993:Recombinant Fusion Proteins; D016572:Cyclosporine; D019703:Calcineurin; D010749:Phosphoprotein Phosphatases; D000591:Amino Acid Isomerases; D022021:Tacrolimus Binding Proteins; D019696:Peptidylprolyl Isomerase; D016559:Tacrolimus