LRRning the RIte of springs.
The determination of the crystal structure of the ribonuclease inhibitor-ribonuclease A complex provides exciting new insight on how the leucine-rich repeat allows a single molecule to get around the problem of inhibiting an entire family of enzymes.
Shapiro
R
R
Riordan
J F
JF
Vallee
B L
BL
D000818:Animals; D003461:Crystallography; D006801:Humans; D007930:Leucine / Q000737:chemistry*; D011487:Protein Conformation; D012091:Repetitive Sequences, Nucleic Acid; D012259:Ribonuclease, Pancreatic / Q000378:metabolism*; D012260:Ribonucleases / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism*; D013552:Swine
D012260:Ribonucleases; D012259:Ribonuclease, Pancreatic; D007930:Leucine