title: Environmentally friendly paper may increase risk of hand eczema in rosin-sensitive persons.
abstract: BACKGROUND
  A connection between patch test reactions to paper extracts and contact allergy to rosin (colophony) has been demonstrated.
  
  
  OBJECTIVE
  We wanted to determine whether a difference in the allergenic activity of various types of paper is related to a difference in the pulp.
  
  
  METHODS
  Patients with dermatitis who were frequently exposed to paper were patch tested with extracts from various papers and the standard series. The extracts were also tested in volunteers with or without contact allergy to rosin and in animals. The rosin compounds in the papers were analyzed by gas chromatography.
  
  
  RESULTS
  The subjects reacting to paper extracts also reacted to rosin. Most reactions were found to the papers produced from mechanical pulps, which contained the highest analyzed amounts of rosin compounds. Animals sensitized to rosin reacted only to paper from mechanical pulp.
  
  
  CONCLUSIONS
  Papers based on mechanical pulps that are considered to be environmentally friendly have a greater potential to elicit positive patch test reactions than papers made from other pulps. The increased use of mechanical pulps in different applications may increase the incidence of rosin-related hand eczema.
authors.affiliation: Department of Occupational Dermatology, National Institute of Occupational Health, Solna, Sweden.
authors.forename: A T
authors.initials: AT
authors.lastname: Karlberg
authors.forename: E
authors.initials: E
authors.lastname: Gäfvert
authors.forename: C
authors.initials: C
authors.lastname: Lidén
mesh_terms: D045784:Abietanes; D000485:Allergens; D000818:Animals; D017449:Dermatitis, Allergic Contact / Q000209:etiology; D017453:Dermatitis, Irritant / Q000209:etiology; D009783:Dermatitis, Occupational / Q000209:etiology*; D004224:Diterpenes / Q000009:adverse effects / Q000032:analysis / Q000737:chemistry; D004485:Eczema / Q000209:etiology*; D005260:Female; D006168:Guinea Pigs; D006229:Hand Dermatoses / Q000209:etiology*; D006801:Humans; D007114:Immunization; D008297:Male; D010209:Paper; D010328:Patch Tests; D010616:Phenanthrenes / Q000009:adverse effects / Q000032:analysis / Q000737:chemistry; D012116:Resins, Plant / Q000009:adverse effects* / Q000032:analysis / Q000737:chemistry
chemical_list: D045784:Abietanes; D000485:Allergens; D004224:Diterpenes; D010616:Phenanthrenes; D012116:Resins, Plant; C013913:dehydroabietic acid; C013893:rosin; C095375:7-oxodehydroabietic acid; C023710:abietic acid