title: DosDNA occurs along yeast chromosomes, regardless of functional significance of the sequence.
abstract: Complex genomes contain numerous simple sequence repeats, the biological significance of which remains obscure. Recently it has been shown that several human diseases are the result of changes in such sequences. Thus it has become urgent to undertake a systematic study of their properties. We have set the task of describing as completely as possible the set of sequences which contain bases organized according to symmetrical elements, the dosDNA: defined ordered sequence. Examination of local anomalies in dinucleotide composition serves to identify dosDNA zones in the genome. The study of chromosomes II, III, VIII and XI of Saccharomyces cerevisiae reveals these dosDNA zones comprise about 2% of the genome. They are regularly distributed along the chromosomes, regardless of the functional significance of the sequence. A more detailed analysis of dosDNA segments seems to indicate that simple repeats are the consequence of local properties of the chromosome, and not due to any motif in particular.
authors.affiliation: Centre de génétique moléculaire du CNRS, Laboratoire associé à l'Université Pierre-et-Marie-Curie et à l'Université Versaille-Saint-Quentin, Gif-sur-Yvette, France.
authors.forename: E
authors.initials: E
authors.lastname: Ollivier
authors.forename: M O
authors.initials: MO
authors.lastname: Delorme
authors.forename: A
authors.initials: A
authors.lastname: Hénaut
mesh_terms: D001483:Base Sequence; D015825:Chromosomes, Fungal / Q000235:genetics*; D004271:DNA, Fungal / Q000737:chemistry*; D014644:Genetic Variation; D008969:Molecular Sequence Data; D012091:Repetitive Sequences, Nucleic Acid; D012441:Saccharomyces cerevisiae / Q000235:genetics*
chemical_list: D004271:DNA, Fungal