title: Recurring oral giant cell lesion in a child with X-linked hypophosphatemic rickets: clinical manifestation of occult parathyroidism?
abstract: A 9-year-old boy with X-linked hypophosphatemic rickets had a recurring oral giant cell lesion. These lesions are relatively uncommon in children and represent a potentially aggressive disorder that is microscopically indistinguishable from the brown tumors of hyperparathyroidism. Subclinical hyperparathyroidism is not uncommon in X-linked hypophosphatemic rickets and may account for the giant cell lesion in this patient.
authors.affiliation: Division of Genetics, Georgetown University Children's Medical Center, Washington, D.C., USA.
authors.forename: C A
authors.initials: CA
authors.lastname: Stratakis
authors.forename: N S
authors.initials: NS
authors.lastname: Mitsiades
authors.forename: D
authors.initials: D
authors.lastname: Sun
authors.forename: G P
authors.initials: GP
authors.lastname: Chrousos
authors.forename: A
authors.initials: A
authors.lastname: O'Connell
mesh_terms: D001706:Biopsy; D002648:Child; D003937:Diagnosis, Differential; D005881:Gingiva / Q000473:pathology; D006101:Granuloma, Giant Cell / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D007015:Hypophosphatemia, Familial / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D012008:Recurrence