title: Symptomatic vitamin E deficiency diagnosed after histological recognition of myometrial lipofuscinosis.
abstract: We report a 44-year-old woman in whom intestinal bypass for obesity at age 23 resulted in chronic malabsorption. After hysterectomy for menorrhagia due to atypical endometrial hyperplasia, the finding of myometrial lipofuscinosis led to a demonstration of vitamin E deficiency. Vitamin E supplementation led to an unexpected improvement in the unsteadiness of gait and slurring of speech of which she had also complained. We suggest that supplementation with vitamin E should be routine in all patients with persistent severe steatorrhoea.
authors.affiliation: Department of Histopathology, St Mary's Hospital Medical School, London, UK.
authors.forename: D J
authors.initials: DJ
authors.lastname: Evans
authors.forename: D M
authors.initials: DM
authors.lastname: Berney
authors.forename: D J
authors.initials: DJ
authors.lastname: Pollock
mesh_terms: D000328:Adult; D002446:Celiac Disease / Q000209:etiology; D004717:Endometrium / Q000473:pathology; D005260:Female; D006801:Humans; D006965:Hyperplasia; D007044:Hysterectomy; D007581:Jejunoileal Bypass / Q000009:adverse effects; D008064:Lipidoses / Q000473:pathology*; D008062:Lipofuscin / Q000032:analysis*; D008286:Malabsorption Syndromes / Q000209:etiology; D008595:Menorrhagia / Q000601:surgery; D009215:Myometrium / Q000473:pathology*; D014591:Uterine Diseases / Q000473:pathology; D014810:Vitamin E / Q000627:therapeutic use; D014811:Vitamin E Deficiency / Q000175:diagnosis* / Q000188:drug therapy
chemical_list: D008062:Lipofuscin; D014810:Vitamin E