[Effect of ciprofloxacin on luminol-dependent chemiluminescence and adhesion of leukocytes].
The in vitro effect of ciprofloxacin on the luminol-dependent chemiluminescence and adherence of polymorphonuclear leukocytes of guinea pigs was studied with the use of a wide variety of the drug concentrations from 0.1 to 1000 micrograms/ml under two different conditions: during incubation of the cells in the presence of the drug different concentrations and after the cell washing to remove ciprofloxacin. In concentrations of 1 to 100 micrograms/ml ciprofloxacin lowered the chemiluminescence at the average by 20 per cent and in a concentration of 1000 micrograms/ml the drug completely inhibited it. In concentrations of 0.1 to 100 micrograms/ml ciprofloxacin lowered as well the leukocyte adherence.
Iordanova
A I
AI
Smolkina
T V
TV
Nikitin
A V
AV
D000818:Animals; D002448:Cell Adhesion / Q000187:drug effects; D002939:Ciprofloxacin / Q000494:pharmacology*; D006168:Guinea Pigs; D066298:In Vitro Techniques; D008163:Luminescent Measurements; D008165:Luminol; D009504:Neutrophils / Q000166:cytology / Q000187:drug effects*; D010587:Phagocytosis / Q000187:drug effects*
D002939:Ciprofloxacin; D008165:Luminol
Vliianie tsiprofloksatsina na liuminolzavisimuiu khemiliuminestsentsiiu i adgeziiu leĭkotsitov.