Alpha-1-acid glycoprotein concentration and the protein binding of disopyramide in healthy subjects.
Age- and gender-related changes in serum alpha 1-acid glycoprotein (AAG) concentration and the serum protein binding of disopyramide were examined after intensive medical examination. Based on the clinical chemistry tests over 51 points, 245 subjects were diagnosed as healthy and 71 subjects (22.5%) revealed an abnormal value for at least one item. In the healthy subjects, serum AAG concentration in men was significantly higher than in women (men, 0.78 +/- 0.18 mg/mL, mean +/- SD; women, 0.67 +/- 0.16 mg/mL). In contrast, there were no significant differences in the AAG concentration between age groups for men and women and in the unbound fraction of disopyramide. Gender changes AAG concentration. Age, however, does not change AAG concentration and the protein binding of the basic drug.
Kishino
S
S
Department of Pharmacy, School of Medicine, Hokkaido University, Sapporo, Japan.
Nomura
A
A
Di
Z S
ZS
Sugawara
M
M
Iseki
K
K
Kakinoki
S
S
Kitabatake
A
A
Miyazaki
K
K
D000293:Adolescent; D000328:Adult; D000367:Age Factors; D000368:Aged; D004206:Disopyramide / Q000097:blood*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009961:Orosomucoid / Q000378:metabolism*; D011485:Protein Binding; D012737:Sex Factors
D009961:Orosomucoid; D004206:Disopyramide