Effects of Linalool on glutamatergic system in the rat cerebral cortex.
Linalool is a monoterpene compound reported to be a major component of essential oils in various aromatic species. Several Linalool-producing species are used in traditional medical systems, including Aeolanthus suaveolens G. Dom (Labiatae) used as anticonvulsant in the Brazilian Amazon. Psychopharmacological in vivo evaluation of Linalool showed that this compound have dose-dependent marked sedative effects at the Central Nervous System, including hypnotic, anticonvulsant and hypothermic properties. The present study reports an inhibitory effect of Linalool on Glutamate binding in rat cortex. It is suggested that this neurochemical effect might be underlining Linalool psychopharmacological effects. These findings provide a rational basis for many of the traditional medical use of Linalool producing plant species.
Elisabetsky
E
E
Depto de Farmacologia, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Marschner
J
J
Souza
D O
DO
D000080462:Acyclic Monoterpenes; D000818:Animals; D000927:Anticonvulsants / Q000494:pharmacology*; D002540:Cerebral Cortex / Q000187:drug effects* / Q000378:metabolism; D018698:Glutamic Acid / Q000378:metabolism*; D008297:Male; D008519:Medicine, Traditional; D039821:Monoterpenes; D051381:Rats; D017208:Rats, Wistar; D013729:Terpenes / Q000494:pharmacology*
D000080462:Acyclic Monoterpenes; D000927:Anticonvulsants; D039821:Monoterpenes; D013729:Terpenes; D018698:Glutamic Acid; C018584:linalool