Immune complexes as monitors of cure in Schistosoma mansoni infected mice.
This study was done to assess the use of immune complexes estimated by micro-ELISA as monitors of cure of schistosomiasis mansoni experimentally infected Swiss albino mice which received praziquantel (PZQ) treatment. They were grouped according to duration of infection (4, 8, 12, 16w) and then subgrouped owing to post-treatment life span (4, 6, 8w). It was found that the changes observed in serum level of immune complexes (IC) would provide a good parameter to demonstrate the severity of infection and being an indication of improvement after treatment. The recorded changes confirmed the relationship between schistosomal hepatic affection and serum levels of IC. The study showed the potent anti-schistosomal effect of PZQ. It cured completely when it was given early after infection or improved moderately when given late.
Khalil
H M
HM
Department of Parasitology, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Bebars
M A
MA
Abdallah
H M
HM
Khalil
N M
NM
el Zayyat
E A
EA
Ismail
M S
MS
D000818:Animals; D000936:Antigen-Antibody Complex / Q000097:blood*; D015415:Biomarkers / Q000097:blood; D004797:Enzyme-Linked Immunosorbent Assay / Q000379:methods; D051379:Mice; D011223:Praziquantel / Q000627:therapeutic use*; D012555:Schistosomiasis mansoni / Q000097:blood / Q000188:drug therapy* / Q000276:immunology; D013997:Time Factors
D000936:Antigen-Antibody Complex; D015415:Biomarkers; D011223:Praziquantel