title: Use of antispasmodic drugs in double contrast barium enema examination: glucagon or buscopan?
abstract: OBJECTIVE
  To compare the spasmolytic effect of glucagon and buscopan in double contrast barium enema examination.
  
  
  METHODS
  Three hundred and twenty-four consecutive patients referred for double contrast barium enema examination were randomly allocated to receive an intravenous injection of either 1 mg of glucagon, 20 mg of buscopan or physiological saline. The transit of the barium column from rectum to caecum, the quality of the radiographs and side effects were assessed blindly without knowledge of the injected drug.
  
  
  RESULTS
  Antispasmodic drugs (glucagon or buscopan) resulted in better transit of the barium column to the caecum compared to placebo (Mann-Whitney: P < 0.05), but no differences occurred between glucagon and buscopan (Mann-Whitney: P > 0.05). Buscopan produced better distension of the rectosigmoid than glucagon or placebo (P < 0.05). Of 109 patients who received buscopan five complained of blurred vision afterwards.
  
  
  CONCLUSIONS
  Because buscopan is less expensive and more effective in distending the colon than glucagon, it is preferred for the routine double contrast examination. However, patients should be warned about the possibility of temporary visual impairment.
authors.affiliation: Department of Radiology, De Wever Hospital, Heelen, The Netherlands.
authors.forename: R
authors.initials: R
authors.lastname: Goei
authors.forename: M
authors.initials: M
authors.lastname: Nix
authors.forename: A H
authors.initials: AH
authors.lastname: Kessels
authors.forename: M P
authors.initials: MP
authors.lastname: Ten Tusscher
mesh_terms: D000328:Adult; D001466:Barium Sulfate; D002086:Butylscopolammonium Bromide / Q000009:adverse effects / Q000627:therapeutic use*; D003106:Colon / Q000187:drug effects; D004311:Double-Blind Method; D004733:Enema / Q000379:methods*; D005260:Female; D005772:Gastrointestinal Transit / Q000187:drug effects; D005934:Glucagon / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
chemical_list: D001466:Barium Sulfate; D002086:Butylscopolammonium Bromide; D005934:Glucagon