Impaired expression of interleukin 2 receptor and CD45RO antigen on lymphocytes from children with acute lymphoblastic leukemia in response to cytomegalovirus and varicella-zoster virus.
The expression of CD25 and CD45RO in lymphocytes from patients with acute lymphoblastic leukemia in response to cytomegalovirus and varicella-zoster virus antigens was analyzed by flow cytometry. It is suggested that the defects in the immune response to cytomegalovirus and varicella-zoster virus in patients with acute lymphoblastic leukemia on chemotherapy are in the expression of CD25 and in the switching of CD45RA cells to CD45RO cells.
Mizutani
K
K
Department of Pediatrics, Mie University School of Medicine, Japan.
Ito
M
M
Nakano
T
T
Kamiya
H
H
Sakurai
M
M
D015704:CD4 Antigens / Q000032:analysis; D002648:Child; D002675:Child, Preschool; D003587:Cytomegalovirus / Q000276:immunology*; D014645:Herpesvirus 3, Human / Q000276:immunology*; D006801:Humans; D017493:Leukocyte Common Antigens / Q000276:immunology*; D008214:Lymphocytes / Q000737:chemistry / Q000276:immunology / Q000821:virology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000276:immunology* / Q000821:virology; D015375:Receptors, Interleukin-2 / Q000032:analysis / Q000276:immunology*
D015704:CD4 Antigens; D015375:Receptors, Interleukin-2; D017493:Leukocyte Common Antigens