Studies on immunomodulatory properties of isoniazid. Influence of isoniazid on responsiveness of peripheral blood mononuclear cells to interleukin-2.
Peripheral blood mononuclear cells which were "resting" i.e. interleukin-2-receptor-negative were stimulated to proliferate by interleukin-2 in vitro. It was found that isoniazid at concentration of 10(-5)-10(-6) M increased the peak proliferation of "resting" cells but had no influence on the kinetics of proliferation. The mechanism of this effect of isoniazid remains unclear.
Kucharz
E J
EJ
Fourth Department of Internal Medicine, Silesian University School of Medicine, Katowice, Poland.
D002455:Cell Division / Q000187:drug effects; D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007376:Interleukin-2 / Q000097:blood / Q000494:pharmacology*; D007538:Isoniazid / Q000494:pharmacology*; D007963:Leukocytes, Mononuclear / Q000187:drug effects*; D015375:Receptors, Interleukin-2 / Q000187:drug effects*; D018709:Statistics, Nonparametric
D007376:Interleukin-2; D015375:Receptors, Interleukin-2; D007538:Isoniazid