Mapping of T-cell epitopes of flagellar antigen d of Salmonella muenchen.
Regions of the antigen d flagellin of Salmonella muenchen capable of causing the proliferation of repolymerized d flagellin-primed T cells were delineated by using dodecameric peptides. Three areas causing substantial DNA replication were identified, together with five areas eliciting less response. On the basis of known salmonella flagellin structure, the major areas were located in highly conserved regions of the molecule.
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Department of Microbiology, Texas Tech University Health Science Center, Lubbock 79430.
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D000595:Amino Acid Sequence; D000818:Animals; D000942:Antigens, Bacterial / Q000737:chemistry*; D000939:Epitopes; D005408:Flagellin / Q000276:immunology*; D066298:In Vitro Techniques; D008213:Lymphocyte Activation; D051379:Mice; D008969:Molecular Sequence Data; D012475:Salmonella / Q000276:immunology*; D013601:T-Lymphocytes / Q000276:immunology*
D000942:Antigens, Bacterial; D000939:Epitopes; D005408:Flagellin