Nitric oxide synthase activities in human myocardium.
Myocardial constitutive and inducible nitric oxide (NO) synthase activities were measured in right ventricular tissue from 17 patients with dilated cardiomyopathy (DCM). A significant activity of inducible enzyme was accompanied by a low activity of the constitutive NO synthase. Thus, the myocardium has the capacity to express both NO synthases. NO may have a physiological as well as a pathological role in the human myocardium.
de Belder
A J
AJ
Department of Cardiology, King's College Hospital, London, UK.
Radomski
M W
MW
Why
H J
HJ
Richardson
P J
PJ
Bucknall
C A
CA
Salas
E
E
Martin
J F
JF
Moncada
S
S
D000594:Amino Acid Oxidoreductases / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D002311:Cardiomyopathy, Dilated / Q000201:enzymology*; D004790:Enzyme Induction; D006801:Humans; D009206:Myocardium / Q000201:enzymology*; D019001:Nitric Oxide Synthase; D051381:Rats
D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases; D002118:Calcium