An angiotensin-converting enzyme gene variant is associated with acute myocardial infarction in women but not in men.
We believe our data may speak to the issue of sexual dimorphism with respect to MI. Most studies have concentrated on men with this disease. In a recent study, Lindpaintner et al10 could find no relationship between the D/D genotype and AMI in subjects of the Physicians Health Study. However, this study consisted entirely of men. The D allele may provide an avenue to discern differences in the pathogenesis of MI in men and women.
Schuster
H
H
Franz Volhard Clinic, Berlin, Germany.
Wienker
T F
TF
Stremmler
U
U
Noll
B
B
Steinmetz
A
A
Luft
F C
FC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005796:Genes; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012727:Sex Characteristics
D007703:Peptidyl-Dipeptidase A