[Monoamine oxidase activity in rat liver in vitamin B12 deficiency].
Changes in the activity of monoamine oxidase (MAO-B) in liver homogenates and mitochondria from normal and vitamin B12-deficient rats have been studied in various functional states of the mitochondria. Preincubation of liver preparation at 32 degrees C increased the MAO affinity for benzylamine in samples of normal (but not vitamin B12-deficient rats). Succinate added to the incubation medium decreased Km and increased Vmax in both normal and vitamin B12-deficient animals. A correlation was found between the decline of MAO-B activity under vitamin B12 deficiency, deceleration of succinate oxidation and reduction of the transmembrane potential.
Gessler
N N
NN
Fedotcheva
N I
NI
Foĭgel'
A G
AG
Alekseeva
N V
NV
Kondrashova
M N
MN
Bykhovskiĭ
V Ia
VIa
D000818:Animals; D008099:Liver / Q000201:enzymology* / Q000503:physiopathology; D008297:Male; D008564:Membrane Potentials; D008995:Monoamine Oxidase / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D014805:Vitamin B 12 / Q000378:metabolism; D014806:Vitamin B 12 Deficiency / Q000201:enzymology* / Q000503:physiopathology
D008995:Monoamine Oxidase; D014805:Vitamin B 12
Monoaminooksidaznaia aktivnost' v pecheni krys pri nedostatochnosti vitamina B12.