title: The antitumour activity of ZD9331, a non-polyglutamatable quinazoline thymidylate synthase inhibitor.
authors.affiliation: CRC Centre for Cancer Therapeutics, Institute of Cancer Research, Sutton, Surrey, UK.
authors.forename: A L
authors.initials: AL
authors.lastname: Jackman
authors.forename: R
authors.initials: R
authors.lastname: Kimbell
authors.forename: M
authors.initials: M
authors.lastname: Brown
authors.forename: L
authors.initials: L
authors.lastname: Brunton
authors.forename: K R
authors.initials: KR
authors.lastname: Harrap
authors.forename: J M
authors.initials: JM
authors.lastname: Wardleworth
authors.forename: F T
authors.initials: FT
authors.lastname: Boyle
mesh_terms: D000818:Animals; D000970:Antineoplastic Agents / Q000627:therapeutic use / Q000633:toxicity*; D001692:Biological Transport; D017322:Clinical Trials, Phase II as Topic; D004351:Drug Resistance; D006801:Humans; D007939:Leukemia L1210 / Q000188:drug therapy; D008727:Methotrexate / Q000378:metabolism / Q000627:therapeutic use / Q000633:toxicity; D051379:Mice; D011799:Quinazolines / Q000378:metabolism / Q000627:therapeutic use* / Q000633:toxicity*; D013329:Structure-Activity Relationship; D013940:Thymidylate Synthase / Q000037:antagonists & inhibitors*
chemical_list: D000970:Antineoplastic Agents; D011799:Quinazolines; C094299:ZD 9331; D013940:Thymidylate Synthase; D008727:Methotrexate