title: [Optimization of the components of intensive care of heart and hemodynamic disorders in patients with acute amitriptyline poisoning].
abstract: Cardio- and hemodynamics were examined in 56 patients with acute suicidal poisonings with amitriptyline, a tricyclic antidepressant, in order to select and optimize the main agents for intensive care of disorders developing in the circulatory system. Adsorption detoxication in parallel with adequate correction of volemic disorders was found to be advisable. A possibility of hemodynamic stabilization in patients with normo- and tachycardia without sharp hypotonia by nonspecific antidotes proserine or obsidan was shown, and by inotropic support with dobutrex in patients with signs of exotoxic shock. The mechanisms underlying the efficacy of therapy are discussed.
authors.forename: V Iu
authors.initials: VIu
authors.lastname: Meledin
authors.forename: V G
authors.initials: VG
authors.lastname: Sentsov
authors.forename: K M
authors.initials: KM
authors.lastname: Brusin
mesh_terms: D000208:Acute Disease; D000293:Adolescent; D000328:Adult; D000368:Aged; D000639:Amitriptyline / Q000506:poisoning*; D003422:Critical Care; D004280:Dobutamine / Q000627:therapeutic use; D005260:Female; D006331:Heart Diseases / Q000139:chemically induced / Q000628:therapy; D006439:Hemodynamics; D006801:Humans; D008297:Male; D008875:Middle Aged; D009388:Neostigmine / Q000627:therapeutic use; D011041:Poisoning / Q000188:drug therapy; D011433:Propranolol / Q000627:therapeutic use; D013406:Suicide, Attempted
chemical_list: D000639:Amitriptyline; D009388:Neostigmine; D004280:Dobutamine; D011433:Propranolol
vernacular_title: Optimizatsiia komponentov intensivnoĭ terapii narusheniĭ kardio- i hemodinamiki u bol'nykh s ostrymi otravleniiami amitriptilinom.