[Effect of cyclosporine on plasma levels of uric acid in patients treated with bone marrow transplantation].
In patients treated with cyclosporine, an increase in the incidence of goiter has been demonstrated. This agent produces changes in the lipidic metabolisms, among which the increase in VLDL stands put. Given that the hyperlipemia more frequently associated to hyperuricemia is the increase of such lipoprotein, we decided to study the behaviour of plasmatic uric acid in patients receiving treatment with cyclosporine. The study was conducted in patients with bone marrow transplant undergoing immunosuppressive therapy, considering the effect of cyclosporine as the only drug or following a scheme of mixed immunosuppression associated to prednisone. We observed a reversible increase in the plasmatic levels of uric acid in patients treated with cyclosporine, which was positively correlated to an increase in VLDL triglycerides. Hence, the cyclosporine produced an increase of uric acid which was neither observed when associated to prednisone nor in the group of self-transplanted patients.
Prada Pardal
J L
JL
Unidad de Lípidos y Arteriosclerosis, Hospital Universitario Reina Sofía, Córdoba.
López Miranda
J
J
Torres Gómez
A
A
Gómez García
P
P
Blanco Cerrada
J
J
Trujillo Santos
J
J
Jansen Chaparro
S
S
López Segura
F
F
Pérez Jiménez
F
F
D016026:Bone Marrow Transplantation; D016572:Cyclosporine / Q000494:pharmacology*; D006801:Humans; D011241:Prednisone / Q000494:pharmacology; D014527:Uric Acid / Q000097:blood*
D014527:Uric Acid; D016572:Cyclosporine; D011241:Prednisone
Efecto de la ciclosporina sobre los niveles plasmáticos de ácido úrico en pacientes trasplantados de médula ósea.