title: [Baclofen pharmacokinetics in rats].
abstract: The pharmacokinetics of baclofen was studied in the rat blood plasma and brain. The concentrations of the agent were found to be considerably lower in the brain than in the plasma. This is associated with the weakly pronounced lipophilicity of the agent in question and with the protective properties of the blood-brain barrier. Baclofen penetrates into the brain middle regions to a greater extent than into cerebral hemispheres.
authors.forename: E D
authors.initials: ED
authors.lastname: Popova
authors.forename: M N
authors.initials: MN
authors.lastname: Puzin
authors.forename: G B
authors.initials: GB
authors.lastname: Kolyvanov
authors.forename: A A
authors.initials: AA
authors.lastname: Litvin
mesh_terms: D000704:Analysis of Variance; D000818:Animals; D001418:Baclofen / Q000032:analysis / Q000493:pharmacokinetics*; D001812:Blood-Brain Barrier; D001921:Brain / Q000378:metabolism; D001923:Brain Chemistry; D001933:Brain Stem / Q000737:chemistry; D002540:Cerebral Cortex / Q000737:chemistry; D002851:Chromatography, High Pressure Liquid / Q000379:methods; D008297:Male; D051381:Rats; D013997:Time Factors
chemical_list: D001418:Baclofen
vernacular_title: Farmakokinetika baklofena u krys.