Nonspecific X-linked mental retardation with macrocephaly and obesity: a further family.
The phenotypic nonspecificity of many forms of X-linked mental retardation has hampered attempts to classify them into clinically homogeneous groups. One such condition, described by Clark and Baraitser [1987: Am J Med Genet 26:13-15], has been the subject of a single pedigree report to date. We now describe a further pedigree whose affected members share many manifestations with those reported by Clark and Baraitser, and we consider the possible distinction between this condition and Atkin-Flaitz syndrome.
Baraitser
M
M
Department of Paediatric Genetics, Hospital for Sick Children, London, United Kingdom.
Reardon
W
W
Vijeratnam
S
S
D001921:Brain / Q000002:abnormalities*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006580:Genetic Carrier Screening; D008040:Genetic Linkage; D006801:Humans; D008607:Intellectual Disability / Q000150:complications / Q000235:genetics*; D008297:Male; D009765:Obesity / Q000150:complications / Q000235:genetics*; D010375:Pedigree; D014960:X Chromosome