title: No influence of pantoprazole on the pharmacokinetics of phenytoin.
abstract: Twenty-three healthy, male volunteers completed this doubleblind, randomized, placebo controlled, 2-period crossover study to assess the influence of multiple doses of pantoprazole on single-dose phenytoin pharmacokinetics. During each treatment period, the volunteers received either one 40 mg pantoprazole tablet or placebo for 7 days. In addition, a single-dose of 300 mg (3 x 100 mg capsules) phenytoin sodium was administered on day 4 of each treatment period. A 14-day wash-out period was allowed between phenytoin administrations. The results indicate that pantoprazole neither affects the rate nor the extent of absorption, nor the elimination of phenytoin.
authors.affiliation: FARMOVS Institute for Clinical Pharmacology and Drug Development, University of the Orange Free State, Bloemfontein, Republic of South Africa.
authors.forename: M V
authors.initials: MV
authors.lastname: Middle
authors.forename: F O
authors.initials: FO
authors.lastname: Müller
authors.forename: R
authors.initials: R
authors.lastname: Schall
authors.forename: G
authors.initials: G
authors.lastname: Groenewoud
authors.forename: H K
authors.initials: HK
authors.lastname: Hundt
authors.forename: R
authors.initials: R
authors.lastname: Huber
authors.forename: H
authors.initials: H
authors.lastname: Bliesath
authors.forename: V W
authors.initials: VW
authors.lastname: Steinijans
mesh_terms: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D000042:Absorption / Q000187:drug effects; D000284:Administration, Oral; D000293:Adolescent; D000328:Adult; D001562:Benzimidazoles / Q000008:administration & dosage / Q000494:pharmacology*; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid; D018592:Cross-Over Studies; D004311:Double-Blind Method; D004347:Drug Interactions; D006801:Humans; D008297:Male; D009853:Omeprazole / Q000031:analogs & derivatives; D000077402:Pantoprazole; D010672:Phenytoin / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D054328:Proton Pump Inhibitors; D012015:Reference Standards; D013454:Sulfoxides / Q000008:administration & dosage / Q000494:pharmacology*; D044465:White People
chemical_list: D053799:2-Pyridinylmethylsulfinylbenzimidazoles; D001562:Benzimidazoles; D054328:Proton Pump Inhibitors; D013454:Sulfoxides; D010672:Phenytoin; D000077402:Pantoprazole; D009853:Omeprazole