title: [A case of liver metastasis of gastric cancer with portal vein tumor thrombosis responding to chemotherapy with 5-FU and epirubicin].
abstract: A 67-year-old male patient having liver metastasis from gastric cancer with portal vein tumor thrombosis was treated by chemotherapy with 5-FU and EPI. A dose of 500 mg/body/day of 5-FU was continuously administered via the central venous catheter. Anorexia and hepatic dysfunction were reduced. In addition, 20 mg/body/week of low-dose EPI was added to the chemotherapy. This treatment produced marked regression of portal vein tumor thrombosis on CT. The side effect observed was slight nausea, but no bone marrow suppression was found. Thus, chemotherapy with 5-FU and EPI appears to be a useful and safe treatment for liver metastasis with portal vein tumor thrombosis.
authors.affiliation: Dept. of Surgery, Tamanagayama Hospital Nippon Medical School.
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshida
authors.forename: I
authors.initials: I
authors.lastname: Egami
authors.forename: M
authors.initials: M
authors.lastname: Onda
mesh_terms: D000230:Adenocarcinoma / Q000188:drug therapy* / Q000556:secondary* / Q000628:therapy; D000368:Aged; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000627:therapeutic use*; D015251:Epirubicin / Q000008:administration & dosage; D005472:Fluorouracil / Q000008:administration & dosage; D006801:Humans; D008113:Liver Neoplasms / Q000188:drug therapy* / Q000556:secondary* / Q000628:therapy; D008297:Male; D010289:Parenteral Nutrition, Total; D011169:Portal Vein; D013274:Stomach Neoplasms / Q000473:pathology*; D013927:Thrombosis / Q000188:drug therapy* / Q000628:therapy
chemical_list: D015251:Epirubicin; D005472:Fluorouracil