Electrode configuration and spread of neural excitation: compartmental models of spiral ganglion cells.
A compartmental model of spiral ganglion cells in a potential field was used to predict spike discharges to electrical stimuli. The field was generated by monopolar, bipolar, or quadrupolar point source electrode geometries. The discharges of a population of afferent neurons were modeled to compare the relative spread of excitation. At the same stimulus intensity the spread of excitation was least for the quadrupolar and greatest for the radial bipolar, and this ordering held after equating for maximal spike discharge rates over the three geometries. Excitation spread from quadrupolar stimulation was highly dependent on stimulus intensity.
Clopton
B M
BM
Center for Bioengineering WD-12, University of Washington, Seattle, USA.
Spelman
F A
FA
D004558:Electric Stimulation; D004566:Electrodes; D005071:Evoked Potentials; D008954:Models, Biological; D013136:Spiral Ganglion / Q000502:physiology*