The functional staging of Duchenne muscular dystrophy using in vivo 31P MR spectroscopy.
We applied 31P magnetic resonance spectroscopy (MRS) for the diagnosis of Duchenne muscular dystrophy (DMD), and evaluated its suitability for early-state DMD diagnosis. The spectral patterns showed typical differences between normal and diseased calf muscle. The signal intensity from each spectrum became weaker with advancing disease stage. We could detect abnormality even at the before imaging modalities.
Ikehira
H
H
Division of Clinical Research, National Institute of Radiological Sciences, Chiba, Japan.
Nishikawa
S
S
Matsumura
K
K
Hasegawa
T
T
Arimizu
N
N
Tateno
Y
Y
D000255:Adenosine Triphosphate / Q000378:metabolism; D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D006801:Humans; D009682:Magnetic Resonance Spectroscopy; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000378:metabolism; D009136:Muscular Dystrophies / Q000175:diagnosis* / Q000378:metabolism; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus
D010725:Phosphocreatine; D010758:Phosphorus; D000255:Adenosine Triphosphate