title: Clonal chromosome changes in non-neoplastic ureters.
abstract: Cytogenetic analysis was performed on 23 samples from non-neoplastic ureters. Clonal chromosome abnormalities were found in eight. They were: loss of Y chromosome, as a single abnormality (five cases) or associated with trisomy 10 and 20 (one case) or with trisomy 2 (one case); and duplication of Y chromosome (one case). Different numerical and structural sporadic abnormalities were found in nine cases. Immunohistochemical analysis and direct observation using the inverted microscope showed that the cells were mainly of the fibroblastic type. FISH analysis with chromosome 7 alpha-satellite probes failed to detect the presence of trisomy 7 in three epithelial cases tested.
authors.affiliation: Biologia Generale e Genetica Medica, Università di Pavia, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Casalone
authors.forename: E
authors.initials: E
authors.lastname: Minelli
authors.forename: R
authors.initials: R
authors.lastname: Righi
authors.forename: P
authors.initials: P
authors.lastname: Granata
authors.forename: E
authors.initials: E
authors.lastname: Meroni
authors.forename: V
authors.initials: V
authors.lastname: Caruso
authors.forename: D
authors.initials: D
authors.lastname: Mazzola
authors.forename: M
authors.initials: M
authors.lastname: Salvadore
authors.forename: E
authors.initials: E
authors.lastname: Pozzi
authors.forename: A V
authors.initials: AV
authors.lastname: Bono
mesh_terms: D000328:Adult; D000368:Aged; D002869:Chromosome Aberrations; D002897:Chromosomes, Human, Pair 7; D002999:Clone Cells; D005260:Female; D006801:Humans; D007124:Immunoenzyme Techniques; D017404:In Situ Hybridization, Fluorescence; D007621:Karyotyping; D008297:Male; D008875:Middle Aged; D014513:Ureter / Q000737:chemistry* / Q000473:pathology* / Q000648:ultrastructure; D014571:Urologic Neoplasms / Q000235:genetics* / Q000648:ultrastructure