Effects of the 6 beta-7 beta-epoxide of 12-O-tetradecanoyl-phorbol-13-acetate on radiation transformation in vitro.
Experiments were performed to compare the abilities of 12-O-tetradecanoyl-phorbol-12-acetate (TPA), croton oil and TPA-6 beta-7 beta-epoxide to enhance radiation transformation in vitro. Both croton oil and TPA-6 beta-7 beta-epoxide were more powerful than TPA in the ability to promote radiation transformation in vitro.
Kennedy
A R
AR
Department of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia 19104, USA.
D000818:Animals; D002471:Cell Transformation, Neoplastic / Q000187:drug effects* / Q000528:radiation effects; D002478:Cells, Cultured; D003436:Croton Oil / Q000494:pharmacology; D004852:Epoxy Compounds; D066298:In Vitro Techniques; D051379:Mice; D013755:Tetradecanoylphorbol Acetate / Q000031:analogs & derivatives*
D004852:Epoxy Compounds; D003436:Croton Oil; D013755:Tetradecanoylphorbol Acetate