Sjögren's syndrome and virus.
Though there have been claims for a key-role for a thus far unknown virus in the pathogenesis of Sjögren's syndrome (SS), conflicting results are to be discussed in this review. One candidate is Epstein-Barr virus which has been found within epithelial cells of labial salivary glands (LSG), using in situ hybridization and polymerase chain reaction. Hepatitis virus C has also been suspected, but an issue has to be made on serological false-positive results. In the light of the detection of the tax gene of human T lymphotropic virus type 1 in LSG, retroviruses have also been incriminated.
Mariette
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Service d'Immuno-Hématologie, Hôpital Saint-Louis, Paris.
D016174:Hepacivirus / Q000302:isolation & purification; D006566:Herpesviridae Infections / Q000150:complications; D004854:Herpesvirus 4, Human; D006801:Humans; D012190:Retroviridae; D012192:Retroviridae Infections / Q000150:complications; D012859:Sjogren's Syndrome / Q000821:virology*; D014412:Tumor Virus Infections / Q000150:complications