V(D)J recombination and the cell cycle.
V(D)J recombination is a major source of antigen receptor diversity and represents the only known form of site-specific DNA rearrangement in vertebrates. V(D)J recombination is initiated by specific DNA cleavage at recombinational signal sequences and requires components of the general machinery used for double-strand (DS)-break repair. The involvement of DS cleavage and repair mechanisms suggests that V(D)J recombination might be coupled to the cell cycle, as introduction or persistence of DS breaks during DNA replication or mitosis could interfere with faithful transmission of genetic information to daughter cells. Here, Weei-Chin Lin and Stephen Desiderio review recent evidence indicating that this is indeed the case and consider some biological implications of this linkage.
Lin
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WC
Dept of Medicine, Duke University Medical Center, Durham, NC 27710, USA.
Desiderio
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S
D000818:Animals; D047390:Casein Kinase II; D002453:Cell Cycle; D004247:DNA / Q000235:genetics / Q000378:metabolism; D004254:DNA Nucleotidyltransferases / Q000502:physiology*; D004268:DNA-Binding Proteins; D018507:Gene Expression Regulation, Developmental; D015322:Gene Rearrangement, B-Lymphocyte; D015329:Gene Rearrangement, T-Lymphocyte; D018398:Homeodomain Proteins; D006801:Humans; D016131:Lymphocyte Subsets / Q000166:cytology / Q000276:immunology; D051379:Mice; D016513:Mice, SCID; D008938:Mitosis; D018448:Models, Immunological; D009687:Nuclear Proteins; D010766:Phosphorylation; D011499:Protein Processing, Post-Translational; D017346:Protein Serine-Threonine Kinases / Q000502:physiology; D011506:Proteins / Q000235:genetics / Q000502:physiology*; D016511:Severe Combined Immunodeficiency / Q000235:genetics / Q000276:immunology; D045567:VDJ Recombinases
D004268:DNA-Binding Proteins; D018398:Homeodomain Proteins; D009687:Nuclear Proteins; D011506:Proteins; C499311:RAG2 protein, human; C499308:Rag2 protein, mouse; C064655:V(D)J recombination activating protein 2; C064658:RAG-1 protein; D004247:DNA; D047390:Casein Kinase II; D017346:Protein Serine-Threonine Kinases; D004254:DNA Nucleotidyltransferases; D045567:VDJ Recombinases