title: Effects of spasmolytic and/or non-steroidal antiinflammatory drugs on muscle hyperalgesia of ureteral origin in rats.
abstract: Rats with artificial calculosis of one ureter develop hyperalgesia in the ipsilateral oblique musculature as evidenced by decreased vocalization threshold to electrical muscle stimulation lasting over a week. The aim of the study was to evaluate the effect on this hyperalgesia of spasmolytic anticholinergic and/or non-steroidal antiinflammatory drugs, common therapies for colic pain in humans. Rats implanted with a unilateral ureteral stone were treated for 10 days with: (1) saline; (2) hyoscine-N-butylbromide (15 mg/kg/day i.p.); (3) ketoprofen (15 mg/kg/day); or (4) hyoscine-N-butylbromide + ketoprofen (15 + 15 mg/kg/day). Oblique muscle vocalization thresholds were measured daily for 3 days before and 10 days after operation. Ipsilateral thresholds decreased significantly after stone implantation on: (1) seven days (max. 32%) for saline; (2) one day (max. 20%) for hyoscine-N-butylbromide; (3) one day (max. 18%) for ketoprofen, but did not change significantly for hyoscine-N-butylbromide + ketoprofen. These results indicate a protective effect against muscle hyperalgesia of ureteral origin by spasmolytic and antiinflammatory drugs, maximal when the two treatments are combined.
authors.affiliation: Pathophysiology of Pain Laboratory, Institute of Medical Pathophysiology, G. D'Annunzio University of Chieti, Italy.
authors.forename: M A
authors.initials: MA
authors.lastname: Giamberardino
authors.forename: R
authors.initials: R
authors.lastname: Valente
authors.forename: P
authors.initials: P
authors.lastname: De Bigontina
authors.forename: S
authors.initials: S
authors.lastname: Iezzi
authors.forename: L
authors.initials: L
authors.lastname: Vecchiet
mesh_terms: D000818:Animals; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000627:therapeutic use*; D002086:Butylscopolammonium Bromide / Q000627:therapeutic use; D004558:Electric Stimulation; D005260:Female; D006930:Hyperalgesia / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D007660:Ketoprofen / Q000627:therapeutic use; D009135:Muscular Diseases / Q000188:drug therapy* / Q000209:etiology* / Q000473:pathology; D010147:Pain Measurement / Q000187:drug effects; D017288:Pain Threshold / Q000187:drug effects; D010276:Parasympatholytics / Q000627:therapeutic use*; D051381:Rats; D017207:Rats, Sprague-Dawley; D014515:Ureteral Diseases / Q000150:complications* / Q000473:pathology
chemical_list: D000894:Anti-Inflammatory Agents, Non-Steroidal; D010276:Parasympatholytics; D002086:Butylscopolammonium Bromide; D007660:Ketoprofen