title: Treatment of tuberculous meningitis in Turkey.
abstract: A prospective study was performed on 72 cases of tuberculous meningitis studying various treatments. 37 patients were treated with a combination of isoniazid, rifampicin, pyrazinamide and streptomycin for 2 months, followed by a combination of isoniazid and rifampicin for 6 months. 35 patients were treated with various combinations of antituberculous drugs for 12-16 months. Disappearance of symptoms took (mean) 17 days. Mean duration of therapy for the hospitalized patients was 36 +/- 4 days. Seven (9.7%) patients died, 5 in the short-course therapy group and 2 in the long-course therapy group. Sequelae persisted in 18 (31%) cases, 8 of which cases were in the short-course therapy group and 10 in the long-course therapy group. No relapse was observed in either of the groups.
authors.affiliation: Department of Infectious Diseases, Erciyes University, Kayseri, Turkey.
authors.forename: M
authors.initials: M
authors.lastname: Doğanay
authors.forename: S
authors.initials: S
authors.lastname: Calangu
authors.forename: H
authors.initials: H
authors.lastname: Turgut
authors.forename: M
authors.initials: M
authors.lastname: Bakir
authors.forename: B
authors.initials: B
authors.lastname: Aygen
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011379:Prognosis; D011446:Prospective Studies; D013997:Time Factors; D014390:Tuberculosis, Meningeal / Q000188:drug therapy* / Q000401:mortality; D014421:Turkey / Q000453:epidemiology
chemical_list: D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents