title: [Reducing hypertension may worsen symptoms of acute apoplexy].
abstract: Patients with acute stroke often present with high blood pressure (BP) on hospital admission. Because hypertension is a risk factor for stroke, and because severe BP elevation may increase oedema and the risk of haemorrhage, acute antihypertensive therapy might seem reasonable. On the other hand, the increase in BP in the acute stage might be considered a beneficial pathophysiological response maintaining the perfusion pressure to the ischaemic area and, in particular, the surrounding penumbra. As illustrated in the case presented here, lowering the BP in the early stage may be associated with progression of neurological deficits, very likely due to a reduction of perfusion to the penumbra thus enlarging the infarct.
authors.affiliation: Klinisk fysiologisk/nuklearmedicinsk afdeling, Bispebjerg Hospital, København.
authors.forename: E
authors.initials: E
authors.lastname: Garde
authors.forename: H S
authors.initials: HS
authors.lastname: Jørgensen
authors.forename: T S
authors.initials: TS
authors.lastname: Olsen
authors.forename: N A
authors.initials: NA
authors.lastname: Lassen
mesh_terms: D000208:Acute Disease; D000368:Aged; D002561:Cerebrovascular Disorders / Q000000981:diagnostic imaging / Q000188:drug therapy* / Q000503:physiopathology; D004110:Diltiazem / Q000008:administration & dosage; D015736:Felodipine / Q000008:administration & dosage; D006801:Humans; D006973:Hypertension / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D011877:Radionuclide Imaging; D012307:Risk Factors
chemical_list: D004110:Diltiazem; D015736:Felodipine
vernacular_title: Blodtryksnedsaettelse kan forvaerre symptomerne ved akut apopleksi.