Psychiatric comorbidity in adolescent inpatients with substance use disorders.
OBJECTIVE
To assess DSM-III-R Axis I and Axis II co-occurrence and comorbidity in adolescent inpatients with substance use disorders (SUD).


METHODS
A consecutive series of 138 adolescent inpatients were reliably assessed with structured diagnostic interviews for Axis I disorders and Axis II personality disorders. To determine significant co-occurrence of diagnoses, comparisons were between 69 patients with SUD and 69 patients without SUD.


RESULTS
Disruptive behavior disorders were diagnosed significantly more frequently in patients with SUD than in those without SUD. Conduct disorder was diagnosed more frequently and oppositional defiant disorder was diagnosed less frequently in the SUD patients than in the non-SUD patients. Anxiety disorders were diagnosed less frequently in the SUD group. Cluster B personality disorders and borderline personality disorder were diagnosed more frequently in the SUD group.


CONCLUSIONS
The findings replicate previous research showing high rates of co-occurrence of other psychiatric disorders in adolescent inpatients with SUD. The use of a relevant psychiatric comparison group allows for finer distinctions regarding significant comorbidity and the psychopathological implications thereof.
Grilo
C M
CM
Yale Psychiatric Institute, Yale University School of Medicine, New Haven, CT 06520-8038, USA.
Becker
D F
DF
Walker
M L
ML
Levy
K N
KN
Edell
W S
WS
McGlashan
T H
TH
D000293:Adolescent; D000298:Adolescent, Hospitalized; D016022:Case-Control Studies; D016009:Chi-Square Distribution; D016000:Cluster Analysis; D017831:Diagnosis, Dual (Psychiatry); D005260:Female; D006801:Humans; D008297:Male; D001523:Mental Disorders / Q000150:complications*; D019964:Mood Disorders / Q000150:complications*; D010554:Personality Disorders / Q000150:complications*; D000297:Psychology, Adolescent; D019966:Substance-Related Disorders / Q000523:psychology*