title: The C-terminal region of the alpha subunit of Escherichia coli RNA polymerase is required for transcriptional activation of the flagellar level II operons by the FlhD/FlhC complex.
abstract: A number of transcription activators have been found to activate transcription via protein-protein contact between RNA polymerase alpha subunits and transcription factors; they are classified as class I factors. In this report, we demonstrate that the FlhD/FlhC complex, a transcription activator of the Escherichia coli flagellar regulon, requires the C-terminal domain of the RNA polymerase alpha subunit for transcription activation. We conclude that FlhD/FlhC is a class I transcription factor.
authors.affiliation: Department of Microbiology and Immunology, University of Illinois at Chicago 60612-7344, USA.
authors.forename: X
authors.initials: X
authors.lastname: Liu
authors.forename: N
authors.initials: N
authors.lastname: Fujita
authors.forename: A
authors.initials: A
authors.lastname: Ishihama
authors.forename: P
authors.initials: P
authors.lastname: Matsumura
mesh_terms: D004268:DNA-Binding Proteins / Q000378:metabolism; D012321:DNA-Directed RNA Polymerases / Q000378:metabolism*; D004926:Escherichia coli / Q000201:enzymology / Q000235:genetics*; D029968:Escherichia coli Proteins; D005407:Flagella / Q000235:genetics*; D015964:Gene Expression Regulation, Bacterial; D009876:Operon / Q000235:genetics; D013329:Structure-Activity Relationship; D015534:Trans-Activators / Q000378:metabolism; D014157:Transcription Factors / Q000378:metabolism*; D014158:Transcription, Genetic
chemical_list: D004268:DNA-Binding Proteins; D029968:Escherichia coli Proteins; D015534:Trans-Activators; D014157:Transcription Factors; C090552:flhC protein, E coli; C090553:flhD protein, E coli; D012321:DNA-Directed RNA Polymerases