[The effect of plasmin-modified proteinase inhibitors on macroglobulin production by human blood mononuclear cells in culture].
A study was made of the influence of plasmin (PL) complexes with alpha 2-macroglobulin (MG) and alpha 2-antiplasmin on secretion of MG, pregnancy-associated alpha 2-glycoprotein (PAG), and pregnancy-associated plasma protein A (PAPP-A) by mononuclear cells (MC), obtained from human peripheral blood. It has been shown that incubation of the MG-PL complexes with MC resulted in the increase in concentrations of all these macroglobulins (MG, PAG, and PAPP-A) in supernatants of cultured MC. We revealed the same effects of AP-PL with regard to the secretion of PZP and PAPP-A. However, this complex was found to suppress MG production by cultured MC. The effects found were dose dependent and some of them differed greatly in men and women, resp.
Zhabin
S G
SG
Zorin
N A
NA
Musatov
M I
MI
D002478:Cells, Cultured; D004305:Dose-Response Relationship, Drug; D005260:Female; D005341:Fibrinolysin / Q000494:pharmacology*; D006801:Humans; D007124:Immunoenzyme Techniques; D007963:Leukocytes, Mononuclear / Q000187:drug effects* / Q000378:metabolism; D008259:Macroglobulins / Q000032:analysis / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D011480:Protease Inhibitors / Q000494:pharmacology*; D012727:Sex Characteristics; D018709:Statistics, Nonparametric
D008259:Macroglobulins; D011480:Protease Inhibitors; D005341:Fibrinolysin
Vliianie modifitsirovannykh plazminom ingibitorov proteinaz na produktsiiu makroglobulinov mononuklearnymi kletkami krovi cheloveka v kul'ture.