The relationship between the adrenoceptor and nonadrenoceptor-mediated effects of imidazoline- and imidazole-containing compounds.
This article brings together work on imidazoline or imidazole-containing compounds concerned with the pharmacology of alpha-adrenoceptors, principally on smooth muscle, to illustrate how imidazolines have contributed to the subclassification of alpha-adrenoceptors and how, against this background, attempts have been made to use this knowledge to uncover "nonadrenoceptor"-mediated biological effects of previously uncharacterized compounds, notably imidazole-containing dipeptides and "clonidine displacing substance" (CDS). Recent data are included on (1) the pharmacology of UK-14304, (2) nonadrenoceptor actions of phentolamine, (3) the pharmacology of tissue extracts containing imidazole-containing dipeptides and CDS activity, and (4) ligand binding data at I1 and I2 sites.
McGrath
J C
JC
Institute of Physiology, University of Glasgow, Scotland.
Brown
C M
CM
Daly
C J
CJ
Kendall
D
D
MacKinnon
A
A
Miller
D J
DJ
Nagadeh
M
M
O'Dowd
A
A
O'Dowd
J J
JJ
Pinthong
D
D
D000818:Animals; D003000:Clonidine / Q000031:analogs & derivatives / Q000378:metabolism; D004151:Dipeptides / Q000378:metabolism; D006801:Humans; D007093:Imidazoles / Q000378:metabolism / Q000494:pharmacology*; D054755:Imidazoline Receptors; D009130:Muscle, Smooth / Q000187:drug effects; D018341:Receptors, Adrenergic, alpha-2 / Q000145:classification / Q000187:drug effects / Q000378:metabolism*; D011955:Receptors, Drug / Q000378:metabolism
D004151:Dipeptides; D007093:Imidazoles; D054755:Imidazoline Receptors; D018341:Receptors, Adrenergic, alpha-2; D011955:Receptors, Drug; C055140:clonidine-displacing substance; D003000:Clonidine