title: [The human genome--chromosome 14].
abstract: In addition to the tandem-like genes of rDNA of ribosomal RNA a special configuration and uncommon implementation is found in loci of receptor chains of T lymphocytes (TCRA, TCRD) and heavy immunoglobulin chain (IGH). In the mature lymphocyte there is, as compared with the germinal genome, its equipment in the above two areas is reduced. Regulators of transcription of these genes may be as a result of chromosomal exchanges which are obviously facilitated by a high local and regional recombination activity, involved in malignant processes. The fourteenth chromosome is the carrier of two genes of heavy myosin chains which by their pathogenic mutations are responsible for hereditary cardiomyopathies. The 14th chromosome is probably also the site of genes controlling the arrangement of internal organs--this is indicated by findings of comparative genetics where the responsible locus is in the close vicinity of locus IGH.
authors.forename: R
authors.initials: R
authors.lastname: Brdicka
mesh_terms: D002874:Chromosome Mapping; D002883:Chromosomes, Human, Pair 14; D005826:Genetics, Medical; D006801:Humans
vernacular_title: Lidský genom--chromozom c. 14.