title: Cerebral blood flow and metabolism in hypertensive patients with cerebral infarction.
abstract: The authors investigated, by positron emission tomography, the effect of long-standing hypertension on cerebral blood flow (CBF) and oxygen metabolism in patients with chronic atherothrombotic brain infarction. In the nonbrain infarct (non-BI) group (n = 13, mean age: sixty-two years), the regional CBF (rCBF) was decreased significantly with a rise in the mean arterial blood pressure (MABP) in the cerebral cortexes (r = -0.575) and the deep gray matter (r = -0.451), whereas the regional cerebral metabolic rate for oxygen (rCMRO2) remained unchanged. In the brain infarct (BI) group (n = 22, mean age: fifty-eight years), however, the rCBF as well as the rCMRO2 were reduced even in the normotensive patients and thus did not correlate with the MABP. These results suggest that long-standing hypertension per se causes a reduction in the rCBF but not in the oxygen metabolism with a compensatory increase in the oxygen extraction fraction. On the other hand, patients with brain infarction, even normotensives, show a diffuse decrease in cerebral circulation and metabolism, which is probably due to the more severe sclerotic changes that take place in the cerebral vessels.
authors.affiliation: Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Nakane
authors.forename: S
authors.initials: S
authors.lastname: Ibayashi
authors.forename: K
authors.initials: K
authors.lastname: Fujii
authors.forename: K
authors.initials: K
authors.lastname: Irie
authors.forename: S
authors.initials: S
authors.lastname: Sadoshima
authors.forename: M
authors.initials: M
authors.lastname: Fujishima
mesh_terms: D001794:Blood Pressure; D001921:Brain / Q000000981:diagnostic imaging / Q000378:metabolism*; D002544:Cerebral Infarction / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology*; D002560:Cerebrovascular Circulation; D016009:Chi-Square Distribution; D002908:Chronic Disease; D005260:Female; D006801:Humans; D006973:Hypertension / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D002537:Intracranial Arteriosclerosis / Q000000981:diagnostic imaging / Q000378:metabolism / Q000503:physiopathology; D016014:Linear Models; D008297:Male; D008875:Middle Aged; D010101:Oxygen Consumption; D010104:Oxygen Radioisotopes; D014055:Tomography, Emission-Computed / Q000379:methods / Q000706:statistics & numerical data
chemical_list: D010104:Oxygen Radioisotopes