title: Oral bioavailability and pharmacokinetics of baquiloprim in dwarf goats.
abstract: The pharmacokinetics of baquiloprim at a dose of 8 mg kg-1 bodyweight were determined after its intravenous and intra-ruminal administration to seven healthy female dwarf goats. After intravenous injection, the plasma elimination curve showed a rapid distribution phase (mean [SD] t1/2 alpha 0.89 [0.4] hours). The mean volume of distribution at steady-state (Vdss) was 14.1 (2.7) litres kg-1 bodyweight. The mean elimination half-life (t1/2 beta) was 14.0 (2.3) hours. After intra-ruminal administration its maximum concentration in plasma (Cmax) was 0.09 (0.01 microgram ml-1 and this maximum was not reached until approximately 35 hours after administration. The systemic oral bioavailability, calculated up to 48 hours after dosing, was 33.7 (7.1) per cent. Owing to a prolonged absorption phase, the data from only four of the goats fitted reasonably to a compartmental model.
authors.affiliation: Department of Veterinary Basic Sciences, Utrecht University, The Netherlands.
authors.forename: J
authors.initials: J
authors.lastname: Lewicki
authors.forename: R F
authors.initials: RF
authors.lastname: Maas
authors.forename: R F
authors.initials: RF
authors.lastname: Witkamp
authors.forename: A S
authors.initials: AS
authors.lastname: Van-Miert
mesh_terms: D000284:Administration, Oral; D000818:Animals; D001682:Biological Availability; D002851:Chromatography, High Pressure Liquid / Q000662:veterinary; D005260:Female; D006041:Goats / Q000378:metabolism*; D007275:Injections, Intravenous; D011743:Pyrimidines / Q000008:administration & dosage / Q000493:pharmacokinetics*
chemical_list: D011743:Pyrimidines; C072761:baquiloprim