Recurring oral giant cell lesion in a child with X-linked hypophosphatemic rickets: clinical manifestation of occult parathyroidism?
A 9-year-old boy with X-linked hypophosphatemic rickets had a recurring oral giant cell lesion. These lesions are relatively uncommon in children and represent a potentially aggressive disorder that is microscopically indistinguishable from the brown tumors of hyperparathyroidism. Subclinical hyperparathyroidism is not uncommon in X-linked hypophosphatemic rickets and may account for the giant cell lesion in this patient.
Stratakis
C A
CA
Division of Genetics, Georgetown University Children's Medical Center, Washington, D.C., USA.
Mitsiades
N S
NS
Sun
D
D
Chrousos
G P
GP
O'Connell
A
A
D001706:Biopsy; D002648:Child; D003937:Diagnosis, Differential; D005881:Gingiva / Q000473:pathology; D006101:Granuloma, Giant Cell / Q000175:diagnosis* / Q000209:etiology / Q000473:pathology; D006801:Humans; D006961:Hyperparathyroidism / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D007015:Hypophosphatemia, Familial / Q000150:complications / Q000175:diagnosis* / Q000473:pathology; D008297:Male; D012008:Recurrence