[Effect of intravenous administration of dalargin on the course and outcome of the body's response to acute massive hemorrhage].
Acute experiments on 74 adult rabbits have revealed that slow fractional jet blood exfusion of 16 +/- 1 ml/kg for 4-5 min results in reversible hemorrhagic shock, but when the volume of blood loss increases up to 23 +/- 3 ml/kg, a fatal shock occurs. The same outcome occurs when one-stage continuous jet blood loss reaches the volume of 16 +/- 3 ml/kg. Preadministration of dalargin, 0.1 mg/kg prior to fatal hemorrhage promotes the survival of most animals and significantly prolongs their longevity. The therapeutical effect of dalargin in increasing the animals' life is shown only when it is used in early shock after fractional hemorrhage. In late shock, the agent fails to affect the further course and outcomes of posthemorrhagic responses after fractional or continuous blood loss.
Sherman
D M
DM
Trach
V M
VM
D000208:Acute Disease; D000818:Animals; D016308:Enkephalin, Leucine-2-Alanine / Q000031:analogs & derivatives* / Q000627:therapeutic use; D006470:Hemorrhage / Q000188:drug therapy*; D007275:Injections, Intravenous; D011817:Rabbits; D016896:Treatment Outcome
D016308:Enkephalin, Leucine-2-Alanine; C040996:enkephalin-Leu, Ala(2)-Arg(6)-
Vliianie vnutrivennogo vvedeniia dalargina na techenie i iskhod reaktsii organizma na ostruiu massivnuiu krovopoteriu.