Microscopic findings of the nail-fold capillaries--dependence on menopausal status and hormone replacement therapy.
The aim of our controlled study was to evaluate peripheral microcirculation at the level of the nail-fold capillaries in relation to menopause status and postmenopausal hormone replacement therapy (HRT). A total of 105 postmenopausal women were randomly allocated to three different HRT groups of equal size. A fourth group of 35 similar healthy volunteers served as controls. HRT was either peroral or transdermal 17-beta-oestradiol with cyclic addition of dydrogesterone or 2.5 mg Tibolone (Org OD 14) in a daily peroral dose. Morphological parameters such as capillary diameters, loop width, papillary width and capillary density, measured by video-capillaroscopy at the nail-fold, were unaffected in early menopause and also under HRT. A significant decrease of capillary blood flow velocity (P < 0.001) could be demonstrated in postmenopausal (n = 41, v = 0.53 +/- 0.16 mm/s) as compared to premenopausal women (n = 37, v = 0.65 +/- 0.15 mm/s). HRT resulted in an increase of capillary blood flow velocity in the nail-fold after 6 and 12 months leading to an increase in capillary blood flow in the order of 20%-30% of the initial values, and was independent of the type of HRT.
Haenggi
W
W
Department of Obstetrics and Gynecology, University of Bern, Switzerland.
Linder
H R
HR
Birkhaeuser
M H
MH
Schneider
H
H
D000279:Administration, Cutaneous; D000284:Administration, Oral; D000328:Adult; D001783:Blood Flow Velocity / Q000187:drug effects; D002196:Capillaries / Q000187:drug effects / Q000502:physiology; D002979:Climacteric / Q000187:drug effects* / Q000502:physiology; D015914:Estrogen Replacement Therapy; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008833:Microcirculation / Q000187:drug effects / Q000502:physiology; D018715:Microscopy, Video; D008875:Middle Aged; D009262:Nails / Q000098:blood supply*; D012016:Reference Values