Cytokines in Sjögren's syndrome.
This review discusses the respective role in Sjögren's syndrome of pro-inflammatory cytokines, such as interleukin (IL)-1 beta and tumour-necrosis factor-alpha, and anti-inflammatory cytokines, such as transforming growth factor-beta, interferon-alpha and IL-10. The former products are secreted by lymphocytes as well as epithelial cells. Th 1 cell cytokines predominate within the focal infiltrates. Increased levels of circulating IL2 receptors correlate to the progression of the ongoing disease.
Skopouli
F N
FN
Dept of Internal Medicine, Medical School, University of Ioannina, Greece.
Moutsopoulos
H M
HM
D016207:Cytokines / Q000276:immunology / Q000502:physiology*; D006801:Humans; D007249:Inflammation / Q000503:physiopathology; D012859:Sjogren's Syndrome / Q000276:immunology / Q000503:physiopathology*; D013601:T-Lymphocytes / Q000276:immunology / Q000502:physiology
D016207:Cytokines