Influx of nonactivated T lymphocytes into the cerebrospinal fluid during relapse of multiple sclerosis.
T lymphocytes were analyzed in the cerebrospinal fluid of 17 patients with multiple sclerosis during and 2 months after an exacerbation. The percentage of activated (HLA-DR+) T lymphocytes was decreased in the cerebrospinal fluid during the relapse but returned thereafter to the level comparable to that in patients with noninflammatory neurological diseases, whereas no fluctuation in the total number of these cells was found. This suggests an influx of nonactivated T lymphocytes into the cerebrospinal fluid at the beginning of the relapse.
Oksaranta
O
O
Turku Immunology Centre, University of Turku, Finland.
Tarvonen
S
S
Ilonen
J
J
Poikonen
K
K
Reunanen
M
M
Panelius
M
M
Salonen
R
R
D000328:Adult; D017252:CD3 Complex / Q000276:immunology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009103:Multiple Sclerosis / Q000134:cerebrospinal fluid* / Q000276:immunology / Q000503:physiopathology; D012008:Recurrence; D013601:T-Lymphocytes / Q000276:immunology*
D017252:CD3 Complex