[Lipoprotein (a) and other risk factors in Chilean children with type I diabetes mellitus].
OBJECTIVE
To study serum Lp(a) levels and other metabolic cardiovascular risk factors in children with type I diabetes mellitus (DM) in comparison with sex and age matched nondiabetic children. To determine the influence of diabetes control on serum lipoprotein (a) concentrations.


METHODS
Transversal observational study.


METHODS
diabetic group: 70 type I DM children without microalbuminuria and no macro-microvascular nor neurological complications, aged from 8 to 15 years; 30 boys, 40 girls. Mean duration of type I DM was 8 +/- 4 years. Non diabetic group: composed by 123 healthy children with no family history of DM, aged from 8 to 15 years, 53 boys, 70 girls.


METHODS
The lipids profile include: total cholesterol (TC) and triglyceride (TG), cholesterol high-density lipoproteins (C-HDL) cholesterol very-low-density lipoproteins (C-LDL) and cholesterol low-density lipoproteins (C-LDL). ApoAI, APOAII and ApoB, Lp(a) and fructosamine.


RESULTS
Fructosamine concentration in diabetic children was 340 +/- 108 uM/1 in 240 +/- 25 uM/l nondiabetic children. Lp(a) serum levels did not significantly differ among both groups 17 +/- 16 mg/dl in diabetics 19 +/- 18 mg/dl in controls. Multivariate analysis showed that in the diabetic children the worsening of metabolic control as reflected by fructosamine, was positively correlated with the increase in total Lp(a) serum concentration.


CONCLUSIONS
In children aged 8-15 years with uncomplicated IDDM lasting less than 15 years duration, Lp(a) serum levels are positively correlated with the poorest metabolic control.
Martínez
M T
MT
Unidad de Lípidos y Diabetes, Hospital Clínico San Carlos, Universidad Complutense, Madrid, España.
Pérez
F
F
Calvillán
M
M
Gutierrez-López
M D
MD
Serrano-Ríos
M
M
D000293:Adolescent; D002648:Child; D002677:Chile; D003327:Coronary Disease / Q000209:etiology; D003922:Diabetes Mellitus, Type 1 / Q000097:blood*; D005260:Female; D006801:Humans; D017270:Lipoprotein(a) / Q000097:blood*; D008297:Male; D012307:Risk Factors
D017270:Lipoprotein(a)
Lipoproteina (a) y otros factores de riesgo en niños chilenos con Diabetes Mellitus Tipo I.