title: Role of ADF/TRX and its inhibitor on the release of major basic protein from human eosinophils.
abstract: Adult T cell leukemia-derived factor (ADF)/Thioredoxin (TRX), originally defined as an IL-2 receptor alpha-chain/p55 inducer, has many cytokine-like activities. We reported that the release of major basic protein (MBP) from mature eosinophils stimulated with cytochalasin B and C5a were augmented after preincubation with recombinant ADF/TRX. The addition of a TRX specific inhibitor, BE40644, suppressed the augmentation of MBP release from mature eosinophils. It is suggested that BE40644 is applicable in allergic diseases associated with eosinophils.
authors.affiliation: Department of Pediatrics and Medical Biology & Parasitology, Jichi Medical School, Tochigi, Japan.
authors.forename: H
authors.initials: H
authors.lastname: Koyanagi
authors.forename: N
authors.initials: N
authors.lastname: Wakasugi
authors.forename: K
authors.initials: K
authors.lastname: Yoshimatsu
authors.forename: Y
authors.initials: Y
authors.lastname: Takashima
authors.forename: J
authors.initials: J
authors.lastname: Yodoi
authors.forename: M
authors.initials: M
authors.lastname: Momoi
authors.forename: T
authors.initials: T
authors.lastname: Suda
authors.forename: T
authors.initials: T
authors.lastname: Kasahara
authors.forename: Y
authors.initials: Y
authors.lastname: Yamaguchi
mesh_terms: D016227:Benzoquinones / Q000494:pharmacology*; D001798:Blood Proteins / Q000378:metabolism*; D016207:Cytokines / Q000494:pharmacology*; D047091:Eosinophil Granule Proteins; D004804:Eosinophils / Q000187:drug effects* / Q000378:metabolism; D006801:Humans; D018836:Inflammation Mediators / Q000378:metabolism*; D015394:Molecular Structure; D009363:Neoplasm Proteins / Q000494:pharmacology*; D012260:Ribonucleases; D013879:Thioredoxins / Q000037:antagonists & inhibitors / Q000494:pharmacology*
chemical_list: C095251:BE 40644; D016227:Benzoquinones; D001798:Blood Proteins; D016207:Cytokines; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D009363:Neoplasm Proteins; C055533:adult T cell leukemia-derived factor; D013879:Thioredoxins; D012260:Ribonucleases