title: Bioprosthetic valve replacement in the elderly.
abstract: One hundred and ten patients aged more than 65 years (mean, 73.4; range, 65-82) underwent successful bioprosthetic valve replacement (aortic, n = 71; mitral, n = 32; both, n = 7) from 1979 to 1985. The valve was pericardial in 39 cases and porcine in 78. The mean follow-up was 75 months (total, 688 patient-years; range, 2 months to 12 years). Actuarial patient survival was 79.4% at 5 years and 55.2% at 10 years. Thirty-seven patients died: 18 from valve-related causes and 19 from other causes. Eight patients have been reoperated on for valve-related complications (1.17% per patient-year): five primary deteriorations, two paravalvular leaks and one case of endocarditis. One surgical death occurred (12.5%). Twenty-five percent of the patients were receiving anticoagulants because of atrial fibrillation, and 5.4% developed severe bleeding (3.8% patient-year). Mid-term follow-up of these patients aged more than 65 years and undergoing bioprosthetic valve replacement surgery revealed a low rate of documented primary structural deterioration (0.9% per patient-year), a low mortality rate on reoperation (12.5%) and a high mortality rate due to non valve-related causes (51.4%).
authors.affiliation: Clinique Cardiologique, l'Hôpital Necker, Paris, France.
authors.forename: G
authors.initials: G
authors.lastname: Helft
authors.forename: X
authors.initials: X
authors.lastname: Tabone
authors.forename: J L
authors.initials: JL
authors.lastname: Georges
authors.forename: E
authors.initials: E
authors.lastname: Lomama
authors.forename: H
authors.initials: H
authors.lastname: Nematalla
authors.forename: J P
authors.initials: JP
authors.lastname: Metzger
authors.forename: A
authors.initials: A
authors.lastname: Heulin
authors.forename: A
authors.initials: A
authors.lastname: Vacheron
mesh_terms: D000368:Aged; D000369:Aged, 80 and over; D000925:Anticoagulants / Q000627:therapeutic use; D001021:Aortic Valve / Q000601:surgery*; D001705:Bioprosthesis; D002423:Cause of Death; D004452:Echocardiography; D005260:Female; D005500:Follow-Up Studies; D006349:Heart Valve Diseases / Q000401:mortality / Q000601:surgery*; D006350:Heart Valve Prosthesis; D006801:Humans; D008297:Male; D008943:Mitral Valve / Q000601:surgery*; D011183:Postoperative Complications / Q000188:drug therapy; D012189:Retrospective Studies; D015996:Survival Rate
chemical_list: D000925:Anticoagulants