[Methylprednisolone pulse therapy combined with plasmapheresis in the treatment of bronchial asthma patients].
16 patients with bronchial asthma received pulse methylprednisolone and underwent plasmapheresis versus 6 controls on pulse-therapy alone. In the study group the response was universal, remission lasted 6-8 months. Clinical stabilization in the controls was much shorter. The above combination reduced depressive effect of methylprednisolone on production of glucocorticosteroid receptors of peripheral blood lymphocytes and endogenic hydrocortisone, IgE and circulating immune complexes.
Tatarskiĭ
A R
AR
Cheglakova
T A
TA
Bobkov
E V
EV
D000328:Adult; D001249:Asthma / Q000503:physiopathology / Q000628:therapy*; D002908:Chronic Disease; D003131:Combined Modality Therapy; D005069:Evaluation Studies as Topic; D005260:Female; D006801:Humans; D008297:Male; D008775:Methylprednisolone / Q000008:administration & dosage*; D008875:Middle Aged; D010913:Pituitary-Adrenal System / Q000187:drug effects; D010956:Plasmapheresis / Q000295:instrumentation / Q000379:methods; D012074:Remission Induction; D012119:Respiration / Q000187:drug effects
D008775:Methylprednisolone
Pul's-terapiia metilprednizolonom v sochetanii s plazmaferezom v lechenii bol'nykh bronkhial'noĭ astmoĭ.