title: Resting metabolic rate in homozygous sickle cell disease.
abstract: The resting metabolic rate in 20 patients with homozygous sickle cell (SS) disease was 19% higher than in 20 age- and sex-matched control subjects with a normal hemoglobin genotype (AA). The difference was not accounted for by differences in lean body mass. It is postulated that this increased energy expenditure reflects the energy expenditure of erythropoietic hyperplasia and leads to a marginal nutritional state that may contribute to the abnormal growth in SS disease.
authors.affiliation: Medical Research Council Laboratories, University of the West Indies, Kingston, Jamaica.
authors.forename: A
authors.initials: A
authors.lastname: Singhal
authors.forename: P
authors.initials: P
authors.lastname: Davies
authors.forename: A
authors.initials: A
authors.lastname: Sahota
authors.forename: P W
authors.initials: PW
authors.lastname: Thomas
authors.forename: G R
authors.initials: GR
authors.lastname: Serjeant
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000378:metabolism*; D000886:Anthropometry; D001481:Basal Metabolism; D015992:Body Mass Index; D015331:Cohort Studies; D005260:Female; D005319:Fetal Hemoglobin / Q000032:analysis; D006454:Hemoglobins / Q000032:analysis; D006720:Homozygote; D006801:Humans; D008297:Male; D011627:Puberty; D012044:Regression Analysis; D015203:Reproducibility of Results
chemical_list: D006454:Hemoglobins; D005319:Fetal Hemoglobin