title: Effect of neuroleptics on phospholipase A2 activity in the brain of rats.
abstract: The effect of neuroleptics on phospholipase A2 (PLA2) activity in rat brain plasma membranes was studied. Chlorpromazine (10 mg/kg), fluphenazine (5 mg/kg), thioridazine (5 mg/kg), trifluoperazine (5 mg/kg), haloperidol (2 mg/kg), and sulpiride (100 mg/kg) were administered to rats intraperitoneally as a single dose or long-term treatment (4 weeks). The PLA2 activity was determined 24, 48, and 72 h after the last injection of a drug. The enzyme activity was decreased after a single or 4-week administration of chlorpromazine, trifluoperazine, haloperidol, and sulpiride. Fluphenazine and thioridazine caused an increase of PLA2 activity in rat brain both after a single dose and long-term administration. For the first time it was shown that neuroleptics cannot only inhibit but also increase, PLA2 activity. Elucidation of this fact requires further studies.
authors.affiliation: Department of Pharmacology, Silesian Academy of Medicine, Katowice-Ligota, Poland.
authors.forename: H I
authors.initials: HI
authors.lastname: Trzeciak
authors.forename: W
authors.initials: W
authors.lastname: Kalaciński
authors.forename: A
authors.initials: A
authors.lastname: Małecki
authors.forename: D
authors.initials: D
authors.lastname: Kokot
mesh_terms: D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D001921:Brain / Q000187:drug effects* / Q000378:metabolism*; D010741:Phospholipases A / Q000378:metabolism*; D054467:Phospholipases A2; D051381:Rats
chemical_list: D014150:Antipsychotic Agents; D010741:Phospholipases A; D054467:Phospholipases A2