Methyl-p-hydroxyphenyllactate-esterase activity and type-II estrogen-binding sites in ovarian cancer: correlation with biological and clinico-pathological parameters.
We examined the levels of activity of methyl-p-hydroxyphenyllactate esterase (MeHPLA-ase) and cytosolic Type-II-estrogen-binding sites (Type-II EBS) in 61 and 71 cases, respectively, of primary ovarian cancer. MeHPLA-ase activity and Type-II EBS were seen to by asymmetrically distributed, in that levels were skewed towards the lower values. A statistically significant direct correlation was found between MeHPLA-ase activity and Type-II EBS. MeHPLA-ase activity and Type-II EBS were inversely correlated with ER and PR levels and showed a trend towards inverse correlation with the percentage of cells in S-phase of the cell cycle. MeHPLA-ase activity and Type-II EBS did not correlate with clinico-pathological parameters. The median MeHPLA-ase activity tended to be higher in responders than in unresponsive patients, but statistical significance was not reached. Higher Type-II-EBS levels were found in cases showing complete and partial response to chemotherapy than in cases which did not respond. A statistically significant relationship was found between high MeHPLA-ase activity and longer overall survival.
Ranelletti
F O
FO
Department of Histology, Catholic University, Rome, Italy.
Scambia
G
G
Benedetti Panici
P
P
Piantelli
M
M
Ferrandina
G
G
D'Agostino
G
G
De Vincenzo
R
R
Rinelli
A
A
Isola
G
G
Mancuso
S
S
D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D004261:DNA Replication; D004950:Esterases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000378:metabolism*; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D016019:Survival Analysis
D002352:Carrier Proteins; D007773:Lactates; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C010140:estrophilin; C055915:methyl 4-hydroxyphenyllactate; D004950:Esterases; D002265:Carboxylic Ester Hydrolases; C095492:methyl-p-hydroxyphenyllactate esterase