Metabolic effects of carbocalcitonin and salmon calcitonin, after endonasal administration in man.
This study evaluates the biological effects caused in healthy males by administration by the endonasal route of 50 IU and 100 IU of salmon calcitonin and 40 IU of carbocalcitonin or (Asu 1.7 eCT), an aminosuberic analogue of eel calcitonin. The comparison among calcitonins administered shows an absorption of carbocalcitonin greater than 50%, still measurable at 240th minute, while the absorptions of salmon calcitonin are shorter. The efficacy of absorption of carbocalcitonin is demonstrated by the magnitude of the biological effects such as decrease of total serum and increase of cAMP.
Cecchettin
M
M
Clinical Pathological Laboratory, Istituto Ortopedico G Pini, Milan, Italy.
Segre
G
G
D000281:Administration, Intranasal; D000328:Adult; D000818:Animals; D002116:Calcitonin / Q000008:administration & dosage* / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000494:pharmacology*; D002118:Calcium / Q000097:blood; D000242:Cyclic AMP / Q000097:blood; D006801:Humans; D008297:Male; D012474:Salmon / Q000378:metabolism*
D002116:Calcitonin; D000242:Cyclic AMP; D002118:Calcium; C012755:elcatonin