Polyphenols from Eriosema tuberosum.
A dichloromethane extract of the roots of Eriosema tuberosum exhibited antifungal activity against Cladosporium cucumerinum and Candida albicans using TLC bioautography. Bioassay-directed fractionation led to the isolation of four new compounds, eriosemaones A-D, together with a known compound, flemichin-D, as the active constituents. Three inactive polyphenols were also isolated after methylation, together with one new chromone, eriosematin. Structures were determined by spectroscopic analysis and from chemical evidence.
Ma
W G
WG
Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Switzerland.
Fuzzati
N
N
Li
Q S
QS
Yang
C R
CR
Stoeckli-Evans
H
H
Hostettmann
K
K
D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002963:Cladosporium / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship
D000935:Antifungal Agents; D002867:Chromones; D010636:Phenols; D010936:Plant Extracts