title: [Changes in cytomembrane and surface cells of the large intestine resulting from the action of sweetening agents].
abstract: Saccharin and cyclamates have been proved to cause organic damage. This work attempt to describe drug-induced changes brought about by drugs in 1/1000 saccharin and cyclamate-fed rats for 90 days. The ultrastructural findings show: microvilli hypertrophy; membranous mitochondrial increase in absorptive cells; and secretion changes in calciform cells. Such changes are cell-response phenomena to interference or mutagenic action on nuclear DNA or on cytoplasmatic metabolism.
authors.affiliation: Cátedra de Histología-Facultad de Medicina, Universidad Nacional de Tucumán.
authors.forename: G
authors.initials: G
authors.lastname: Torres de Mercau
authors.forename: N
authors.initials: N
authors.lastname: Riera de Martínez Villa
authors.forename: G A
authors.initials: GA
authors.lastname: Mercau
authors.forename: N
authors.initials: N
authors.lastname: Martínez Riera
authors.forename: N
authors.initials: N
authors.lastname: Soria de Santos
authors.forename: H
authors.initials: H
authors.lastname: Vitalone
mesh_terms: D000818:Animals; D002462:Cell Membrane / Q000187:drug effects / Q000648:ultrastructure; D003494:Cyclamates / Q000009:adverse effects* / Q000633:toxicity; D004032:Diet; D005260:Female; D007420:Intestine, Large / Q000187:drug effects* / Q000648:ultrastructure*; D008297:Male; D051379:Mice; D008809:Mice, Inbred C3H; D012439:Saccharin / Q000009:adverse effects* / Q000633:toxicity
chemical_list: D003494:Cyclamates; D012439:Saccharin
vernacular_title: Alteraciones en la citomembrana y células de superficie del intestino grueso por acción de los edulcorantes.