Regulation of nuclear transcription factors by stress signals.
1. A diverse array of stressful stimuli induces changes in gene expression via post-translational modification of transcription factors. 2. Study of activator protein (AP-1) transcription factor regulation has revealed a novel family of protein-serine kinases. Molecular cloning and expression of these proteins have demonstrated their specific activation by stress stimuli such as UV irradiation, heat, ischaemia/reperfusion and metabolic toxins. 3. Dissection of the regulation of the stress-activated protein kinases has revealed a similar but distinct mechanism to mitogen-activated protein kinases suggesting that cellular responses to stress may partially overlap with normal growth responses and have common nuclear targets.
Woodgett
J R
JR
Ontario Cancer Institute, Toronto, Canada.
Avruch
J
J
Kyriakis
J M
JM
D003001:Cloning, Molecular; D015971:Gene Expression Regulation, Enzymologic / Q000187:drug effects / Q000235:genetics*; D006358:Hot Temperature; D010766:Phosphorylation; D014176:Protein Biosynthesis / Q000235:genetics; D011499:Protein Processing, Post-Translational / Q000235:genetics; D017346:Protein Serine-Threonine Kinases / Q000235:genetics / Q000378:metabolism*; D015427:Reperfusion Injury; D015398:Signal Transduction / Q000235:genetics; D014118:Toxins, Biological / Q000633:toxicity; D018808:Transcription Factor AP-1 / Q000235:genetics*; D014158:Transcription, Genetic / Q000235:genetics; D014466:Ultraviolet Rays
D014118:Toxins, Biological; D018808:Transcription Factor AP-1; D017346:Protein Serine-Threonine Kinases