Angelol-type coumarins from Angelica pubescence F. biserrata and their inhibitory effect on platelet aggregation.
An ethyl acetate-soluble root extract of Angelica pubescence f. biserrata afforded two new angelol-type coumarins, angelols K and L, in addition to angelols B, C, D and G. Some of the compounds were tested on human platelet aggregation and showed significant activity.
Liu
J H
JH
Department of Phytochemistry, Liaoning College of Traditional Chinese Medicine, Shenyang.
Xu
S X
SX
Yao
X S
XS
Kobayashi
H
H
D001241:Aspirin / Q000494:pharmacology; D003374:Coumarins / Q000737:chemistry* / Q000302:isolation & purification* / Q000494:pharmacology; D006801:Humans; D010936:Plant Extracts / Q000737:chemistry; D018517:Plant Roots; D010946:Plants, Medicinal; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013329:Structure-Activity Relationship
D003374:Coumarins; D010936:Plant Extracts; D010975:Platelet Aggregation Inhibitors; D001241:Aspirin