Correlation between serotonergic measures in cerebrospinal fluid and blood of subhuman primate.
The relationship between the concentration of serotonin (5-hydroxytryptamine; 5-HT), its precursor; tryptophan (Trp) and the main metabolite 5-hydroxyindoleacetic acid (5-HIAA) in cerebrospinal fluid (CSF) and blood of monkey have been studied. 5-HT, Trp and 5-HIAA underwent circadian changes in both CSF and blood. Significant correlations were found between 5-HT, 5-HIAA and Trp in CSF and blood. The significance of these findings and their relationship to the use of peripheral serotonergic system as a functional model of the central nervous system are discussed.
Yan
D
D
Department of Physiology, Hamamatsu University School of Medicine, Handa-cho, Japan.
Urano
T
T
Pietraszek
M H
MH
Shimoyama
I
I
Uemura
K
K
Kojima
Y
Y
Sakakibara
K
K
Serizawa
K
K
Takada
Y
Y
Takada
A
A
D000818:Animals; D002940:Circadian Rhythm; D005260:Female; D006897:Hydroxyindoleacetic Acid / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D008251:Macaca; D008297:Male; D012701:Serotonin / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid; D014364:Tryptophan / Q000032:analysis* / Q000097:blood / Q000134:cerebrospinal fluid
D012701:Serotonin; D006897:Hydroxyindoleacetic Acid; D014364:Tryptophan