[Production of tumor necrosis factor alpha and interleukin-6 by peripheral monocytes from patients with atypical mycobacteriosis--relationship to clinical activity].
The production of tumor necrosis factor alpha (TNF alpha) and of interleukin-6 (IL-6) by peripheral blood monocytes (PBMs) from patients infected with Mycobacterium avium intracellular complex (MAC) were assessed. Spontaneous release of both TNF alpha and IL-6 were greater during the active stage than during the inactive stage and in healthy controls. When the cells were stimulated with MAC-derived purified protein derivative B (PPD-B). TNF alpha production by PBMs in the active stage increased and IL-6 production by cells in both the active and inactive stages decreased. Moreover, the in vitro increase in TNF alpha production after stimulation in the active stage seemed to be related to the persistent MAC infection, which resulted in an exhaustion of nutrition. These results suggest that the ability of PBMs to produce TNF alpha and IL-6 in vitro is closely related to the clinical stage of MAC infection.
Tomoda
K
K
Second Department of Internal Medicine, Nara Medical University.
Yoneda
T
T
Tsukaguchi
K
K
Yoshikawa
M
M
Tokuyama
T
T
Fu
A
A
Fukuoka
K
K
Nakaya
M
M
Narita
N
N
Tasaka
H
H
D000368:Aged; D002478:Cells, Cultured; D006801:Humans; D015850:Interleukin-6 / Q000096:biosynthesis*; D008875:Middle Aged; D009000:Monocytes / Q000276:immunology / Q000378:metabolism*; D015270:Mycobacterium avium-intracellulare Infection / Q000276:immunology*; D014373:Tuberculin / Q000276:immunology; D014397:Tuberculosis, Pulmonary / Q000276:immunology*; D014409:Tumor Necrosis Factor-alpha / Q000096:biosynthesis*
D015850:Interleukin-6; D014373:Tuberculin; D014409:Tumor Necrosis Factor-alpha