title: 4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency.
authors.affiliation: Department of Medicinal Chemical Research, Molecular Systems, and Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
authors.forename: R K
authors.initials: RK
authors.lastname: Bakshi
authors.forename: G H
authors.initials: GH
authors.lastname: Rasmusson
authors.forename: G F
authors.initials: GF
authors.lastname: Patel
authors.forename: R T
authors.initials: RT
authors.lastname: Mosley
authors.forename: B
authors.initials: B
authors.lastname: Chang
authors.forename: K
authors.initials: K
authors.lastname: Ellsworth
authors.forename: G S
authors.initials: GS
authors.lastname: Harris
authors.forename: R L
authors.initials: RL
authors.lastname: Tolman
mesh_terms: D058891:5-alpha Reductase Inhibitors; D000736:Androstenes / Q000737:chemistry / Q000494:pharmacology*; D001378:Azasteroids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D013816:Thermodynamics
chemical_list: D058891:5-alpha Reductase Inhibitors; D000736:Androstenes; D001378:Azasteroids