title: [Interleukin-2 activity in monocrotaline-treated rat lungs].
abstract: To study the relationship between cytokines and the development of monocrotaline-induced pulmonary hypertension, monocrotaline was given and interleukin-2 was measured. The amount of interleukin-2 produced by pulmonary cells obtained by bronchoalveolar lavage was high only on the 14th day after monocrotaline injection (p < 0.01). This suggests that many kinds of cells in the monocrotaline-treated rat lung were activated by cytokines, and that these interactions play an important role in the development of monocrotaline-induced pulmonary hypertension in rats.
authors.affiliation: Department of Chest Medicine, School of Medicine, Chiba University.
authors.forename: A
authors.initials: A
authors.lastname: Suzuki
authors.forename: I
authors.initials: I
authors.lastname: Kakusaka
authors.forename: K
authors.initials: K
authors.lastname: Kiyatake
authors.forename: K
authors.initials: K
authors.lastname: Nakano
authors.forename: N
authors.initials: N
authors.lastname: Kaneko
authors.forename: T
authors.initials: T
authors.lastname: Kuriyama
mesh_terms: D000818:Animals; D006976:Hypertension, Pulmonary / Q000209:etiology / Q000276:immunology*; D007376:Interleukin-2 / Q000378:metabolism*; D008168:Lung / Q000166:cytology / Q000378:metabolism*; D008297:Male; D016686:Monocrotaline; D051381:Rats; D017207:Rats, Sprague-Dawley
chemical_list: D007376:Interleukin-2; D016686:Monocrotaline