title: Multiple familial cavernous malformations evaluated over three generations with MR.
abstract: MR imaging was used to determine the presence or absence of cavernous malformations in three generations of family members. The presenting child (proband) had sustained a symptomatic hemorrhage. Multiple malformations were identified in his father, in an older sibling, and in an asymptomatic grandfather. The father's brother had died from cavernous malformation-related intracerebral hemorrhage. Increasing numbers of malformations were found with increasing patient age, suggesting that MR-apparent lesions may grow in number as a result of repetitive small hemorrhages over time.
authors.affiliation: Department of Neurological Surgery, Presbyterian University Hospital, University of Pittsburgh, School of Medicine, PA, USA.
authors.forename: M
authors.initials: M
authors.lastname: Horowitz
authors.forename: D
authors.initials: D
authors.lastname: Kondziolka
mesh_terms: D000328:Adult; D000368:Aged; D001921:Brain / Q000473:pathology; D001932:Brain Neoplasms / Q000175:diagnosis / Q000235:genetics*; D002648:Child; D002675:Child, Preschool; D005260:Female; D006392:Hemangioma, Cavernous / Q000175:diagnosis / Q000235:genetics*; D006801:Humans; D008279:Magnetic Resonance Imaging; D008297:Male; D009378:Neoplasms, Multiple Primary / Q000175:diagnosis / Q000235:genetics*; D009386:Neoplastic Syndromes, Hereditary / Q000175:diagnosis / Q000235:genetics*; D010375:Pedigree; D012307:Risk Factors