title: Chemoprophylaxis of multidrug-resistant tuberculous infection in HIV-uninfected individuals using ciprofloxacin and pyrazinamide. A decision analysis.
abstract: OBJECTIVE
  To evaluate the use of ciprofloxacin and pyrazinamide for the prophylaxis of individuals infected with multiply drug-resistant strains of Mycobacterium tuberculosis.
  
  
  METHODS
  Decision analysis, using software (SMLTREE). Probabilities based on published studies, with sensitivity analysis for each probability.
  
  
  METHODS
  Health-care workers infected with multidrug-resistant strains of M tuberculosis.
  
  
  METHODS
  Prophylaxis with ciprofloxacin and pyrazinamide.
  
  
  RESULTS
  We calculated the utilities of taking or not taking prophylaxis with ciprofloxacin and pyrazinamide. The decision analysis favored the use of ciprofloxacin-pyrazinamide prophylaxis by a small margin.
  
  
  CONCLUSIONS
  Ciprofloxacin-pyrazinamide prophylaxis should be considered for health-care workers infected with multiply drug-resistant M tuberculosis.
authors.affiliation: Center for International Health, Case Western Reserve University School of Medicine, Cleveland, OH 44106, USA.
authors.forename: J P
authors.initials: JP
authors.lastname: Stevens
authors.forename: T M
authors.initials: TM
authors.lastname: Daniel
mesh_terms: D000328:Adult; D002939:Ciprofloxacin / Q000009:adverse effects / Q000627:therapeutic use*; D003661:Decision Support Techniques; D003663:Decision Trees; D018023:HIV Seronegativity; D006282:Health Personnel; D006801:Humans; D009784:Occupational Diseases / Q000382:microbiology / Q000517:prevention & control*; D011336:Probability; D011718:Pyrazinamide / Q000009:adverse effects / Q000627:therapeutic use*; D012680:Sensitivity and Specificity; D012984:Software; D018088:Tuberculosis, Multidrug-Resistant / Q000517:prevention & control*; D014397:Tuberculosis, Pulmonary / Q000517:prevention & control*
chemical_list: D011718:Pyrazinamide; D002939:Ciprofloxacin