Superoxide dismutase activity of the captopril-iron complex.
With an assay that generates superoxide anion radicals without the intervention of metal ions we investigated the antioxidant properties of captopril, an angiotensin-converting enzyme inhibitor with a sulfhydryl group. Under these conditions, increasing concentrations of the drug were seen not to scavenge O.-2 directly. However, a combination of captopril and iron could bring about the breakdown of the superoxide anion; a result that may help to understand the free radical-scavenging properties of captopril.
Jay
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Department of Biochemistry, State University of New York (HSCB) 11203-2098, USA.
Cuella
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Jay
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D000975:Antioxidants / Q000378:metabolism; D002216:Captopril / Q000378:metabolism* / Q000494:pharmacology; D005290:Ferric Compounds / Q000378:metabolism*; D005562:Formazans / Q000378:metabolism; D016166:Free Radical Scavengers / Q000378:metabolism*; D005609:Free Radicals / Q000378:metabolism; D009580:Nitroblue Tetrazolium / Q000378:metabolism; D013482:Superoxide Dismutase / Q000378:metabolism*; D013481:Superoxides / Q000378:metabolism
D000975:Antioxidants; D005290:Ferric Compounds; D005562:Formazans; D016166:Free Radical Scavengers; D005609:Free Radicals; D013481:Superoxides; D009580:Nitroblue Tetrazolium; D002216:Captopril; D013482:Superoxide Dismutase