title: Removal and efflux of copper from Cu-metallothionein as Cu/tetrathiomolybdate complex in LEC rats.
abstract: Tetrathiomolybdate (TTM) removes copper (Cu) accumulating in a form bound to metallothionein (MT) in the liver of LEC rats (Long-Evans rats with a cinnamon-like coat color). The first step in the removal of Cu from Cu-MT has been shown to form a complex between MT and TTM through (MT)-S-Cu-S-(TTM) bridges (referred to as MT/TTM complex). Additional TTM was demonstrated to remove Cu from MT/TTM complex as the second step to form Cu/TTM complex by liberating MT. The Cu/TTM complex binds specifically to albumin in serum and to high molecular weight proteins in the absence of albumin, and is assumed to be a form of Cu for efflux by the treatment with TTM.
authors.affiliation: Faculty of Pharmaceutical Sciences, Chiba University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Ogra
authors.forename: K T
authors.initials: KT
authors.lastname: Suzuki
mesh_terms: D000818:Animals; D002104:Cadmium / Q000378:metabolism; D003300:Copper / Q000378:metabolism*; D008668:Metallothionein / Q000378:metabolism*; D008982:Molybdenum / Q000378:metabolism*; D011485:Protein Binding; D051381:Rats; D017208:Rats, Wistar; D012709:Serum Albumin / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
chemical_list: D012709:Serum Albumin; D002104:Cadmium; D003300:Copper; D008982:Molybdenum; D008668:Metallothionein; C020809:tetrathiomolybdate; D015032:Zinc