title: Inhibitory effect of xian-qing-long-tan extract on degranulation and histamine release from rat mast cells.
abstract: Xian-Qing-Long-Tang (XQLT), a Chinese medicine, is useful for treating allergic diseases. To demonstrate the anti-allergic effect of this drug we examined its effect on degranulation and histamine release from rat mast cells induced by antigen and compound 48/80. The effect on 48 h homologous passive cutaneous anaphylaxis (PCA) in rats was also studied. In the IgE antigen-antibody reaction using DNP-As, XQLT inhibited histamine release from rat mast cells, in vitro; it also inhibited 48 h rat homologous PCA reaction, in vivo. These results suggest that XQLT inhibits type 1 allergic reaction, and has effectiveness for allergic disease.
authors.affiliation: Department of Otorhinolaryngology, Osaka Prefectural Hospital, Japan.
authors.forename: T
authors.initials: T
authors.lastname: Matsumoto
authors.forename: M
authors.initials: M
authors.lastname: Ishida
authors.forename: M
authors.initials: M
authors.lastname: Makino
authors.forename: T
authors.initials: T
authors.lastname: Shibata
authors.forename: S
authors.initials: S
authors.lastname: Ogino
authors.forename: T
authors.initials: T
authors.lastname: Matsunaga
mesh_terms: D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D000947:Antigens, Helminth / Q000008:administration & dosage; D001200:Ascaris / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology; D015550:Cell Degranulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D007114:Immunization; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
chemical_list: D000942:Antigens, Bacterial; D000947:Antigens, Helminth; D004365:Drugs, Chinese Herbal; D003189:p-Methoxy-N-methylphenethylamine