title: [Role of thymopentin in the prevention of post-splenectomy infections].
abstract: The Authors evaluated the efficacy of thymopentin in the prevention of post-splenectomy infections. 14 splenectomized patients treated by thymopentin (50 mg s.c. every other day in the 4 weeks following splenectomy) were compared with 14 splenectomized control patients. Clinical evaluations and measurement of CD4 and CD8 lymphocyte subpopulations were made preoperatively and then after 3 and 6 months from splenectomy. Hyperthermia (37.5-38 degrees C) "sine materia", which disappeared spontaneously in 4-5 weeks, was observed in the post-operative phase in 4 control patients and in 1 patient treated by thymopentin. No statistical difference was demonstrated comparing pre- and post-operative percentages of CD4 and CD8 lymphocytes in the treated and control groups.
authors.affiliation: Dipartimento di Chirurgia, Università degli Studi di Catania.
authors.forename: R
authors.initials: R
authors.lastname: Vecchio
authors.forename: M
authors.initials: M
authors.lastname: Ferrara
authors.forename: F
authors.initials: F
authors.lastname: Mosca
authors.forename: G
authors.initials: G
authors.lastname: Messina
authors.forename: A
authors.initials: A
authors.lastname: Ignoto
authors.forename: M
authors.initials: M
authors.lastname: Di Martino
authors.forename: F
authors.initials: F
authors.lastname: Latteri
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D006801:Humans; D017053:Infection Control; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D013156:Splenectomy / Q000009:adverse effects*; D016305:Thymopentin / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
chemical_list: D016305:Thymopentin
vernacular_title: Il ruolo della timopentina nella prevenzione delle infezioni post-splenectomia.