title: [A rare case of malignant otitis external in a non-diabetic patient].
abstract: One case of malignant external otitis in a non-diabetic patient is presented. Malignant external otitis is a rare but severe bacterial infection, caused by Pseudomonas aeruginosa, predominantly in elderly diabetic patients. The process starts in the external auditory canal and after crossing the cartilaginous-osseus junction invades the connective tissue, cartilage, bone, and nerves of the temporal bone and the surrounding parts of the base of the skull. The clinical syndrome is a severe, painful inflammation of the external auditory canal with edematous obstruction of the external canal and typical granulation tissue in the canal wall. Diagnostic criteria are pain, edema, exudate, granulations, microabscess, diabetes, old age, identification of Pseudomonas aeruginosa, and even cranial nerve involvement. Further important criteria are failure of local treatment and a positive Tc-99 scan demonstrating osteomyelitis of the temporal bone as a sign of connective tissue, cartilage, and bone invasion. In most cases there is also a positive radiograph or HR-CT of the base of the skull. Except for sequestrations, surgical treatment in malignant external otitis is impractical because of the deep penetration into the base of the skull and the lack of demarcation lines in this diffuse pathological process. Nowadays long term i.v. antibiotic therapy is preferred. In our case we applied Ceftazidim (Fortum) 2 g for 12 weeks twice a day. After this period the patient was completely cured. Our case demonstrates that malignant external otitis should be considered even in non-diabetic patients.
authors.affiliation: HNO-Univ.-Klinik Graz.
authors.forename: W
authors.initials: W
authors.lastname: Anderhuber
authors.forename: C
authors.initials: C
authors.lastname: Walch
authors.forename: W
authors.initials: W
authors.lastname: Köle
mesh_terms: D000368:Aged; D002442:Ceftazidime / Q000008:administration & dosage; D002511:Cephalosporins / Q000008:administration & dosage; D003952:Diagnostic Imaging; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006801:Humans; D008297:Male; D010019:Osteomyelitis / Q000175:diagnosis* / Q000188:drug therapy; D010032:Otitis Externa / Q000175:diagnosis* / Q000188:drug therapy; D011552:Pseudomonas Infections / Q000175:diagnosis* / Q000188:drug therapy; D011550:Pseudomonas aeruginosa / Q000187:drug effects
chemical_list: D002511:Cephalosporins; D002442:Ceftazidime
vernacular_title: Der seltene Fall einer Otitis externa maligna beim Nichtdiabetiker.