Retro-orbital late relapse in a child with leukaemia after allogeneic bone marrow transplantation.
Relapse after allogeneic bone marrow transplantation (BMT) usually occurs in the bone marrow and is often associated with a poor prognosis. Isolated extramedullary relapse following BMT is exceedingly rare. We observed an isolated relapse in the left retro-orbital region of a 13-year-old girl, 3 years after BMT performed for acute lymphoblastic leukaemia in third complete remission. Computerized tomography revealed a tumor at the inferomedial part of the orbit infiltrating the maxillary and ethmoid sinuses and nasal cavities and also involving the rectus muscles. Histology demonstrated a monomorphic leukaemia infiltrate. Complete disappearance of the retro-orbital mass was obtained with chemotherapy and local irradiation.
Colombini
A
A
Department of Paediatric Haematology, Milan University, Italy.
Barzaghi
A
A
Castagneto
M
M
Bovo
G
G
Rossi
M R
MR
Rovelli
A
A
Uderzo
C
C
D000293:Adolescent; D016026:Bone Marrow Transplantation; D005260:Female; D006801:Humans; D009918:Orbital Neoplasms / Q000188:drug therapy / Q000532:radiotherapy / Q000556:secondary*; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012008:Recurrence; D012074:Remission Induction