Urinary beta-glucuronidase in screening and followup of primary urinary tract malignancy.
OBJECTIVE
The usefulness of urinary beta-glucuronidase in screening and followup of urinary tract malignancy was tested.


METHODS
The activity and concentration of urinary beta-glucuronidase were determined in 80 healthy subjects, 113 urology patients with no cancer, and 60 with transitional cell and 23 with renal cell carcinoma. Patients with cancer were followed for 3 to 33 weeks.


RESULTS
The enzyme activity and concentration were significantly greater in the cancer group, including residual tumor or recurrence after therapy, than in the controls with excellent discrimination.


CONCLUSIONS
Urinary beta-glucuronidase was indeed useful in screening and followup of urinary tract malignancy.
Ho
K J
KJ
Department of Laboratory Medicine, National Taiwan University, College of Medicine, Taipei.
D000328:Adult; D000368:Aged; D002292:Carcinoma, Renal Cell / Q000175:diagnosis / Q000201:enzymology* / Q000652:urine; D002295:Carcinoma, Transitional Cell / Q000175:diagnosis / Q000201:enzymology* / Q000652:urine; D005500:Follow-Up Studies; D005966:Glucuronidase / Q000652:urine*; D006801:Humans; D007680:Kidney Neoplasms / Q000175:diagnosis / Q000201:enzymology* / Q000652:urine; D008875:Middle Aged; D011237:Predictive Value of Tests; D012372:ROC Curve; D012680:Sensitivity and Specificity
D005966:Glucuronidase