Is glaucoma associated with an increased risk of cataract?
OBJECTIVE
The risk of developing cataract in patients with untreated glaucoma or with ocular hypertension was evaluated by comparing the values of lenticular autofluorescence and light transmission in 16 patients with primary open angle glaucoma and 22 patients with ocular hypertension with those of 24 healthy controls.


METHODS
Increase of lenticular autofluorescence and decrease of transmission values in comparison with controls were considered to be precursors of cataract. The values of both variables were determined by fluorophotometry. Each value was normalised for age by dividing it by the value for a healthy control of the same age.


RESULTS
The mean age normalised autofluorescence and transmission values of all patients did not differ significantly from those of the controls (difference < 5%; p = 0.6 and p = 0.2, respectively). Also the mean age normalised autofluorescence and transmission values between glaucoma and ocular hypertension patients did not differ significantly (p = 0.8 and p = 0.9, respectively).


CONCLUSIONS
The study indicates that untreated primary open angle glaucoma or untreated ocular hypertension do not seem to increase significantly the risk of developing cataract.
Kuppens
E V
EV
Department of Ophthalmology, Leiden University Hospital, The Netherlands.
van Best
J A
JA
Sterk
C C
CC
D000328:Adult; D000368:Aged; D002386:Cataract / Q000209:etiology*; D005453:Fluorescence; D015590:Fluorophotometry; D005902:Glaucoma, Open-Angle / Q000150:complications* / Q000503:physiopathology; D006801:Humans; D007908:Lens, Crystalline / Q000503:physiopathology; D008027:Light; D008875:Middle Aged; D009798:Ocular Hypertension / Q000150:complications* / Q000503:physiopathology; D012307:Risk Factors