Sertindole antagonizes morphine-, cocaine-, and methamphetamine-induced place preference in the rat.
The motivational effect of sertindole, a limbic selective antipsychotic drug, was investigated in rats using a non-biased conditioned place preference method which could reliably detect the reinforcing effects of morphine, cocaine and methamphetamine. Sertindole (0.01-1.0 mg/kg, s.c.), like haloperidol and fluphenazine, produced neither place preference nor place aversion. However, sertindole, at a dose of 1.0 mg/kg, s.c., completely abolished the place preferences induced by morphine (8.0 mg/kg, i.p.), cocaine (4.0 mg/kg, i.p.) and methamphetamine (2.0 mg/kg i.p.). These results strongly suggest that sertindole itself does not induce a rewarding effect and may have therapeutic value in the treatment of drug abuse.
Suzuki
T
T
Department of Pharmacology, School of Pharmacy, Hoshi University, Tokyo, Japan.
Misawa
M
M
D000818:Animals; D014150:Antipsychotic Agents / Q000494:pharmacology*; D003042:Cocaine / Q000037:antagonists & inhibitors*; D003216:Conditioning, Operant / Q000187:drug effects; D005476:Fluphenazine / Q000494:pharmacology; D006220:Haloperidol / Q000494:pharmacology; D007093:Imidazoles / Q000494:pharmacology*; D007211:Indoles / Q000494:pharmacology*; D008297:Male; D008694:Methamphetamine / Q000037:antagonists & inhibitors*; D009020:Morphine / Q000037:antagonists & inhibitors*; D009292:Narcotic Antagonists / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012201:Reward; D013037:Spatial Behavior / Q000187:drug effects*
D014150:Antipsychotic Agents; D007093:Imidazoles; D007211:Indoles; D009292:Narcotic Antagonists; D008694:Methamphetamine; D009020:Morphine; C066304:sertindole; D003042:Cocaine; D006220:Haloperidol; D005476:Fluphenazine