Effects of Visnea mocanera extracts on the bleeding time, gastrointestinal transit and diuresis in rodents.
The present study examined the effect of several extracts of Visnea mocanera L. on the bleeding time and gastrointestinal transit in mice using the Duke test and charcoal meal method, respectively; they were also investigated in order to examine their renal effects. Results showed that V. mocanera extracts significantly inhibited both the bleeding time and gastrointestinal transit in mice. No diuretic activity of these extracts were detected. In contrast, they significantly reduced the urine volume. The study provides experimental support to the therapeutic advocation of V. mocanera in ethnomedicine for the treatment of diarrhoea and the healing of wounds.
Hernández-Pérez
M
M
Departamento de Farmacología, Facultad de Farmacia, Universidad de La Laguna, Tenerife, Spain.
Sánchez-Mateo
C C
CC
Darias
V
V
Rabanal
R M
RM
D000818:Animals; D001760:Bleeding Time; D002606:Charcoal / Q000008:administration & dosage; D004231:Diuresis / Q000187:drug effects*; D004573:Electrolytes / Q000652:urine; D005772:Gastrointestinal Transit / Q000187:drug effects*; D008297:Male; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D051381:Rats; D017208:Rats, Wistar; D013030:Spain
D004573:Electrolytes; D010936:Plant Extracts; D002606:Charcoal