Zinc, copper and magnesium status in insulin-dependent diabetes.
In 20 patients with insulin-dependent diabetes mellitus the concentration of zinc in serum was 56.53 +/- 2.36 micrograms/dl (mean +/- SD). This was significantly lower (p < 0.01) than the levels measured in matched controls. In the same patients the concentrations of serum copper and magnesium were 123.46 +/- 6.59 micrograms/dl and 17.38 +/- 0.52 mg/l respectively. These copper values were higher and the magnesium levels were lower than in the control subjects (p < 0.01). These changes may be associated with the development of insulin resistance and it is proposed that patients will improve if trace elements are given as part of the therapy.
Isbir
T
T
University of Cukurova Medical Faculty, Department of Biochemistry, Adana, Turkey.
Tamer
L
L
Taylor
A
A
Isbir
M
M
D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003300:Copper / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008274:Magnesium / Q000097:blood*; D008297:Male; D015032:Zinc / Q000097:blood*
D003300:Copper; D008274:Magnesium; D015032:Zinc