[Role of thymopentin in the prevention of post-splenectomy infections].
The Authors evaluated the efficacy of thymopentin in the prevention of post-splenectomy infections. 14 splenectomized patients treated by thymopentin (50 mg s.c. every other day in the 4 weeks following splenectomy) were compared with 14 splenectomized control patients. Clinical evaluations and measurement of CD4 and CD8 lymphocyte subpopulations were made preoperatively and then after 3 and 6 months from splenectomy. Hyperthermia (37.5-38 degrees C) "sine materia", which disappeared spontaneously in 4-5 weeks, was observed in the post-operative phase in 4 control patients and in 1 patient treated by thymopentin. No statistical difference was demonstrated comparing pre- and post-operative percentages of CD4 and CD8 lymphocytes in the treated and control groups.
Vecchio
R
R
Dipartimento di Chirurgia, Università degli Studi di Catania.
Ferrara
M
M
Mosca
F
F
Messina
G
G
Ignoto
A
A
Di Martino
M
M
Latteri
F
F
D000293:Adolescent; D000328:Adult; D000368:Aged; D016516:CD4-CD8 Ratio; D006801:Humans; D017053:Infection Control; D008875:Middle Aged; D011183:Postoperative Complications / Q000517:prevention & control*; D013156:Splenectomy / Q000009:adverse effects*; D016305:Thymopentin / Q000008:administration & dosage / Q000627:therapeutic use*; D013997:Time Factors
D016305:Thymopentin
Il ruolo della timopentina nella prevenzione delle infezioni post-splenectomia.