[Detection of chromosome aberrations in peripheral T-cell lymphomas by fluorescence in situ hybridization].
Using fluorescence in situ hybridization (FISH) technique, we have detected trisomy 3(+3) and gain of an extra X chromosome (+X) in 32 (78%) and 14 (34%) of 41 patients with peripheral T-cell lymphomas, respectively. However, cells with trisomy 3 and +X were, on average, 4.5% and 8.2%, respectively. The study showed that trisomy 3 and +X were the specific chromosome aberrations of peripheral T-cell lymphoma; cells with +3 and +X constituted only a small part in a specimen: FISH was more sensitive than traditional cytogenetics in detection of chromosome aberrations.
Zhang
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Zhejiang Medical University, Hangzhou.
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002869:Chromosome Aberrations; D005260:Female; D006801:Humans; D007119:Immunoblastic Lymphadenopathy / Q000235:genetics; D017404:In Situ Hybridization, Fluorescence; D008228:Lymphoma, Non-Hodgkin / Q000235:genetics; D016411:Lymphoma, T-Cell, Peripheral / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014314:Trisomy; D014960:X Chromosome