Gene structure at the human UGT1 locus creates diversity in isozyme structure, substrate specificity, and regulation.
Owens
I S
IS
Section on Genetic Disorders of Drug Metabolism, National Institute of Child Health and Human Development, Bethesda, Maryland 20892-1830, USA.
Ritter
J K
JK
D000595:Amino Acid Sequence; D000818:Animals; D001663:Bilirubin / Q000378:metabolism; D005091:Exons; D015971:Gene Expression Regulation, Enzymologic; D014644:Genetic Variation; D014453:Glucuronosyltransferase / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D007527:Isoenzymes / Q000737:chemistry / Q000235:genetics* / Q000378:metabolism; D008969:Molecular Sequence Data; D010636:Phenols / Q000378:metabolism; D051381:Rats; D017386:Sequence Homology, Amino Acid; D013379:Substrate Specificity
D007527:Isoenzymes; D010636:Phenols; D014453:Glucuronosyltransferase; D001663:Bilirubin