title: Continuous and massive intake of chitosan affects mineral and fat-soluble vitamin status in rats fed on a high-fat diet.
abstract: We investigated the effects of continuous and massive intake of chitosan with sodium ascorbate (AsN) on the mineral and the fat-soluble vitamin status in male Sprague-Dawley rats fed on a high-fat diet. The apparent fat digestibility in the chitosan-receiving group was significantly lower than that in the cellulose- or glucosamine-receiving group. Chitosan feeding for 2 weeks caused a decrease in mineral absorption and bone mineral content, and it was necessary to administer twice the amount of Ca in the AIN-76 formula, which was supplemented with AsN, to prevent such a decrease in the bone mineral content. Moreover, the ingestion of chitosan along with AsN led to a marked and rapid decrease in the serum vitamin E level, while such a loss in vitamin E was not observed for rats given glucosamine monomer instead of chitosan.
authors.affiliation: Applied Bioreseach Center, Kirin Brewery Co., Ltd., Gunma, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Deuchi
authors.forename: O
authors.initials: O
authors.lastname: Kanauchi
authors.forename: M
authors.initials: M
authors.lastname: Shizukuishi
authors.forename: E
authors.initials: E
authors.lastname: Kobayashi
mesh_terms: D000818:Animals; D001205:Ascorbic Acid / Q000378:metabolism; D015519:Bone Density / Q000187:drug effects; D002614:Chelating Agents / Q000494:pharmacology*; D002686:Chitin / Q000031:analogs & derivatives* / Q000494:pharmacology; D048271:Chitosan; D004032:Diet; D004041:Dietary Fats / Q000494:pharmacology*; D008297:Male; D008903:Minerals / Q000378:metabolism*; D009752:Nutritional Status / Q000187:drug effects*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013054:Spectrophotometry, Atomic; D014801:Vitamin A / Q000378:metabolism; D014810:Vitamin E / Q000378:metabolism; D014812:Vitamin K / Q000378:metabolism; D014815:Vitamins / Q000378:metabolism*; D015430:Weight Gain / Q000187:drug effects
chemical_list: D002614:Chelating Agents; D004041:Dietary Fats; D008903:Minerals; D014815:Vitamins; D014801:Vitamin A; D014812:Vitamin K; D002686:Chitin; D014810:Vitamin E; D048271:Chitosan; D001205:Ascorbic Acid