[The role of transaminases and mitochondrial anion porters in the energetics of animals of different ages].
Aminohydroxyacetate, an inhibitor of aminotransferases, decreases the rate of oxygen consumption by 1-day-old young rats by 35% 10 min after intraperitoneal injection, whereas for 20-day-old rats, the inhibitory effect is 56%, and for adult mice, it is 83%. More prolonged exposure to aminohydroxyacetate leads to death of the animal. One-day-old rats die 90 min after the injection, 20-day-old rats die 30 min after the injection, and adult mice die 15 min after the injection. Butylmalonate (an inhibitor of mitochondrial dicarboxylate translocator) decreases the rate of energy metabolism to a lower extent, by 38% in adult mice and by 18% in 1-day-old rats. The animals generally remain alive after the exposure to this compound. 1,2,3-benzyltricarboxylate, an inhibitor of tricarboxylate transport, shows only a weak effect on energy metabolism of animals of any age. These results provide evidence that the role of the transaminase system in energy metabolism increases with age. Mechanisms underlying weak sensitivity of newborn animals to these inhibitors are discussed.
Akhmerov
R N
RN
Sultanov
Sh
Sh
Allamuratov
Sh I
ShI
D000375:Aging / Q000187:drug effects / Q000378:metabolism*; D000625:Aminooxyacetic Acid / Q000494:pharmacology; D000818:Animals; D017920:Antiporters / Q000187:drug effects / Q000378:metabolism*; D001555:Benzene Derivatives / Q000494:pharmacology; D002352:Carrier Proteins / Q000037:antagonists & inhibitors; D029382:Dicarboxylic Acid Transporters; D003998:Dicarboxylic Acids / Q000037:antagonists & inhibitors; D004734:Energy Metabolism / Q000187:drug effects / Q000502:physiology*; D008314:Malonates / Q000494:pharmacology; D051379:Mice; D008929:Mitochondria, Heart / Q000187:drug effects / Q000378:metabolism*; D010101:Oxygen Consumption / Q000187:drug effects / Q000502:physiology; D051381:Rats; D000637:Transaminases / Q000187:drug effects / Q000378:metabolism*; D014233:Tricarboxylic Acids / Q000494:pharmacology
D017920:Antiporters; D001555:Benzene Derivatives; D002352:Carrier Proteins; D029382:Dicarboxylic Acid Transporters; D003998:Dicarboxylic Acids; D008314:Malonates; D014233:Tricarboxylic Acids; C020723:citrate-binding transport protein; D000625:Aminooxyacetic Acid; C027734:n-butylmalonic acid; C004288:benzene 1,2,3-tricarboxylic acid; D000637:Transaminases
Rol' transaminaz i anionperenoschikov mitokhondriĭ v énergetike zhivotnykh raznogo vozrasta.