[Preoperative management of uterine leiomyomatosis using pituitary gonadotropin-releasing hormone analogues].
Uterine leiomyomatosis shows a frequency from 25 to 30% in reproductive age women. Traditional treatment is hysterectomy or myomectomy independently from fertility wishes of the woman. Its growth has been associated to estrogenic activity. Because of this, several substances have been used to diminish tumour size, pre-operatively. The use of analogues of liberating hormone of hypophysiary gonadotropins (GnRH), given to favor surgical technique, to diminish trans-operative bleeding and to avoid blood transfusions. Clinical efficiency of the use of nafarelin acetate in women with uterine leyomiomatosis, pre-operatively during three months, was studied in this paper. The study was prospective, comparative, blind and with longitudinal measurements. Twenty eight women were included. Group I (n = 13) and Group II (n = 15) control without treatment. Observation units included FSH, LH, E2, BHC, HCT, USG basal, 30, 60, 90 days. Results showed a diminution of more than 80% of the initial uterine volume, and of 30% of the myomas independently measured. Side effects, tolerance and efficacy of the used compound, are mentioned.
Bustos López
H H
HH
Instituto Nacional de Perinatología, México, D.F.
Miranda Rodríguez
J A
JA
Kably Ambe
A
A
Serviere Zaragoza
C
C
Espinoza de los Monteros
A
A
Alvarado Durán
A
A
D000328:Adult; D000367:Age Factors; D004311:Double-Blind Method; D005260:Female; D007987:Gonadotropin-Releasing Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives*; D006801:Humans; D007258:Informed Consent; D007889:Leiomyoma / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*; D008137:Longitudinal Studies; D017274:Nafarelin / Q000008:administration & dosage*; D011300:Preoperative Care; D011446:Prospective Studies; D014463:Ultrasonography; D014594:Uterine Neoplasms / Q000000981:diagnostic imaging / Q000188:drug therapy / Q000601:surgery*
D017274:Nafarelin; D007987:Gonadotropin-Releasing Hormone
Tratamiento médico preoperatorio de leiomiomatosis uterina con análogos de hormona liberadora de gonadotropinas hipofisarias.