title: Mood and anxiety fluctuation in Parkinson's disease associated with levodopa infusion: preliminary findings.
abstract: Pilot data on mood and anxiety changes in 15 Parkinson's disease patients with motor fluctuations are described based on ratings every 30 min for 5 h bracketing a 2-h constant-rate levodopa infusion. Robust mood and anxiety effects slightly preceded but temporally paralleled fluctuations in motor tapping scores. Research nurse ratings blind to patient ratings corroborated the changes. The magnitude of changes in mood and anxiety scores did not correlate with the magnitude of changes in tapping scores. The findings of this uncontrolled study suggest mood and anxiety fluctuations may be a common and potentially important component of levodopa-induced fluctuations.
authors.affiliation: Department of Psychiatry, Oregon Health Sciences University, Portland 97201, USA.
authors.forename: R A
authors.initials: RA
authors.lastname: Maricle
authors.forename: J G
authors.initials: JG
authors.lastname: Nutt
authors.forename: J H
authors.initials: JH
authors.lastname: Carter
mesh_terms: D000339:Affect / Q000187:drug effects*; D000368:Aged; D001007:Anxiety / Q000139:chemically induced* / Q000523:psychology; D001143:Arousal / Q000187:drug effects; D002230:Carbidopa / Q000008:administration & dosage / Q000009:adverse effects; D003863:Depression / Q000139:chemically induced / Q000523:psychology; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D005260:Female; D006801:Humans; D007262:Infusions, Intravenous; D007980:Levodopa / Q000008:administration & dosage / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009048:Motor Skills / Q000187:drug effects*; D009460:Neurologic Examination / Q000187:drug effects; D010300:Parkinson Disease / Q000188:drug therapy* / Q000523:psychology
chemical_list: D007980:Levodopa; D002230:Carbidopa