Reversible alopecia after single-dose methotrexate treatment in a patient with ectopic pregnancy.
OBJECTIVE
To report a case of a women who received a single 50 mg/m2 dose of methotrexate (MTX) on two occasions for two separate ectopic pregnancies. After both treatments the patient experienced reversible alopecia.


METHODS
Case report.


METHODS
Single human patient in a university-run clinic.


METHODS
A patient with an ectopic pregnancy presenting for treatment on two separate occasions.


METHODS
A single dose of 50 mg/m2 MTX given to the patient on both occasions.


METHODS
Loss of scalp hair.


RESULTS
On two separate occasions the patient lost a significant portion (33% to 50%) of her scalp hair.


CONCLUSIONS
Even single-dose MTX as used for the treatment of ectopic pregnancy may induce alopecia in a susceptible patient.
Trout
S
S
University of Medicine and Dentistry of New Jersey (UMDNJ)-Robert Wood Johnson Medical School, New Brunswick 08901, USA.
Kemmann
E
E
D000328:Adult; D000505:Alopecia / Q000139:chemically induced*; D005260:Female; D006801:Humans; D008727:Methotrexate / Q000008:administration & dosage / Q000627:therapeutic use*; D011247:Pregnancy; D011271:Pregnancy, Ectopic / Q000188:drug therapy*
D008727:Methotrexate