Prenatal lorazepam exposure: 4. Persistent alterations in pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake after prenatal lorazepam exposure.
Prenatal benzodiazepine exposure is associated with behavioral and neurochemical alterations in the early postnatal period. To determine the persistence of these effects, we evaluated pentylenetetrazole-induced seizure threshold and GABA-dependent chloride uptake in mice at 6 and 12 months of age after prenatal lorazepam exposure. Seizure threshhold was reduced after acute lorazepam pretreatment in mice exposed to lorazepam prenatally, compared to control groups, at 6 and 12 months of age. Maximal GABA-dependent chloride uptake was also reduced in exposed mice at 6 and 12 months of age. These data indicate that behavioral and neurochemical alterations persist well into maturity after prenatal lorazepam exposure.
Koff
J M
JM
Department of Pharmacology and Experimental Therapeutics, Tufts University School of Medicine, Boston, MA 02111, USA.
Miller
L G
LG
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects; D002712:Chlorides / Q000378:metabolism*; D002713:Chlorine; D005260:Female; D008140:Lorazepam / Q000494:pharmacology*; D051379:Mice; D009118:Muscimol / Q000494:pharmacology; D010433:Pentylenetetrazole; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D011868:Radioisotopes; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*; D005680:gamma-Aminobutyric Acid / Q000502:physiology*
D002712:Chlorides; D011868:Radioisotopes; D009118:Muscimol; D002713:Chlorine; D005680:gamma-Aminobutyric Acid; D008140:Lorazepam; D010433:Pentylenetetrazole