[The inhibitory effect of intraperitoneal hyperthermic and hypotonic chemotherapy on ascites cancer cells in mice].
To study the effect of inhibition of intraperitoneal hyperthermic hypotonic chemotherapy on the ascites cacer cells, LACA mice were given intraperitoneal injection of H22 cancer cells (2 x 10(7) tumor cell, each mouse). At 24 hours after the cancer injection, intraperitoneal simple hyperthermic (43 C) hypotonic fluid group (I), isotonic fluid group (II), cis-Diamminodichloroplatinum (DDP) group (IV) and hyperthermic hypotonic fluid perfusion combined with DDP group (V) were processed. The results showed that cancer cells in LACA mice peritoneal cavity were seriously damaged, the ascites growing was obviously inhibited, and the survival days of LACA mice were prolonged in all groups; however, the intraperitoneal hyperthermic hypotonic fluid perfusion with DDP group (V) presented greater effect compared with the other groups. This might be a new therapeutic procedure for the prevention and treatment of cancer ascites in the patients with digestive tract malignancies.
Chen
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Peng
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Tan
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D000818:Animals; D002286:Carcinoma, Ehrlich Tumor / Q000188:drug therapy* / Q000473:pathology; D002945:Cisplatin / Q000627:therapeutic use*; D005260:Female; D006358:Hot Temperature; D007038:Hypotonic Solutions; D007263:Infusions, Parenteral / Q000379:methods; D008297:Male; D051379:Mice; D009368:Neoplasm Transplantation
D007038:Hypotonic Solutions; D002945:Cisplatin