Comparison of eltanolone and thiopental in anaesthesia for termination of pregnancy.
Eltanolone, a new steroid hypnotic, was compared to thiopental in short anaesthesia. Sixty unpremedicated, Asa 1-2 women were randomized to receive eltanolone 0.6 (group E1) or 0.8 mg.kg-1 (group E2) or thiopental 4 mg.kg-1 (group T) for induction of anaesthesia. One minute before induction glycopyrrolate 0.2 mg and alfentanil 15 micrograms.kg-1 i.v. were administered. If induction failed, additional boluses of the test drug were given. Anaesthesia was maintained with 67% nitrous oxide in oxygen, and additional bolus doses of the test drug were given in a standardized fashion, if needed. Recovery was assessed by a research nurse blinded to the agent used. Mean +/- s.d. induction doss were 0.7 +/- 0.1 mg.kg-1 (group E1), 0.8 +/- 0.1 mg.kg-1 (group E2) and 4.0 +/- 0.0 mg.kg-1 (group T). Induction time was prolonged in the group E1 compared to the other two groups (P < 0.05). Side effects were few in all groups, but involuntary muscle movements or hypertonus occurred in 23% of the patients in the eltanolone and in 3% in the thiopental groups (n.s). Early recovery (eye opening, orientation and sitting) was slower in both eltanolone groups compared to the thiopental group (P < 0.01). No differences between the groups were found in toleration of oral fluids, walking, voiding, postoperative analgesic requirements or postoperative nausea and vomiting.(ABSTRACT TRUNCATED AT 250 WORDS)
Eriksson
H
H
Departments I and II of Obstetrics and Gynecology, Helsinki University Central Hospital, Finland.
Haasio
J
J
Korttila
K
K
D000028:Abortion, Induced; D000293:Adolescent; D000328:Adult; D000762:Anesthesia Recovery Period; D000771:Anesthesia, Intravenous; D000773:Anesthesia, Obstetrical; D018686:Anesthetics, Intravenous / Q000008:administration & dosage* / Q000009:adverse effects; D005133:Eye Movements / Q000187:drug effects; D005260:Female; D006801:Humans; D008875:Middle Aged; D018482:Muscle, Skeletal / Q000187:drug effects; D009949:Orientation; D010351:Patient Discharge; D011187:Posture; D011247:Pregnancy; D011280:Pregnanolone / Q000008:administration & dosage* / Q000009:adverse effects; D011597:Psychomotor Performance / Q000187:drug effects; D013874:Thiopental / Q000008:administration & dosage* / Q000009:adverse effects
D018686:Anesthetics, Intravenous; D011280:Pregnanolone; D013874:Thiopental