Evaluation of a new preservation solution: Celsior in the isolated rat lung. Paris-Sud University Lung Transplatation Group.
BACKGROUND
We compared Celsior solution, a new and original extracellular preservation solution, with blood-based Wallwork's solution.


METHODS
In two groups of isolated rat lungs submitted to 4 hours of cold ischemia, pulmonary arterial and venous resistances, coefficient of filtration, and wet-to-dry lung weight ratio were determined at baseline and after 90 minutes of reperfusion.


RESULTS
After ischemia-reperfusion, percentage of increases above the respective baseline coefficient of filtration values were 93% +/- 7% in the Wallwork group and 7% +/- 3% in the Celsior group (p < 0.001 versus Wallwork's solution).


CONCLUSIONS
These results show that Celsior consistently prevented the ischemia-reperfusion-induced increase in pulmonary microvascular permeability as compared with Wallwork's solution.
Reignier
J
J
Laboratoire de Chirurgie Expérimentale, Centre chirurgical Marie Lannelongue, Plessis-Robinson, France.
Mazmanian
M
M
Chapelier
A
A
Alberici
G
G
Ménasché
P
P
Weiss
M
M
Hervé
P
P
D000418:Albumins / Q000494:pharmacology; D000818:Animals; D002199:Capillary Permeability / Q000187:drug effects; D002712:Chlorides / Q000494:pharmacology; D004187:Disaccharides / Q000494:pharmacology; D004573:Electrolytes / Q000494:pharmacology; D005971:Glutamates / Q000494:pharmacology; D005978:Glutathione / Q000494:pharmacology; D006639:Histidine / Q000494:pharmacology; D008168:Lung / Q000098:blood supply*; D008297:Male; D008353:Mannitol / Q000494:pharmacology; D009926:Organ Preservation; D011422:Propionates / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D015427:Reperfusion Injury / Q000517:prevention & control*; D012996:Solutions
D000418:Albumins; C088453:Celsior; D002712:Chlorides; D004187:Disaccharides; D004573:Electrolytes; D005971:Glutamates; D011422:Propionates; D012996:Solutions; C089639:Wallwork solution; D008353:Mannitol; D006639:Histidine; D005978:Glutathione