title: A new mutant rat with hyperbilirubinuria (hyb).
abstract: We have discovered mutant rats with hyperbilirubinuria at the laboratories of Eisai Co., Ltd., Gifu, Japan, and established a new inbred mutant strain, which was designated Eisai Hyperbilirubinuria Rat (EHBR/Eis). They show jaundice immediately after birth, and direct or conjugated hyperbilirubinemia throughout their life. The phenotypes are controlled by a single autosomal recessive gene, hyb with full penetrance. Affected homozygous males seem to have full reproductive capacity. On the other hand, the litter size of hyb/hyb females is significantly reduced at second parturition compared with that at first one. In order to maintain the strain efficiently and to produce both affected (hyb/hyb) and normal control (hyb/+) offspring at the same time, we have mainly been mating hyb/hyb males with hyb/+ females in establishing the inbred strain. We also report here the allele distribution of the EHBR/Eis strain.
authors.affiliation: Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Yamazaki
authors.forename: T
authors.initials: T
authors.lastname: Mikami
authors.forename: S
authors.initials: S
authors.lastname: Hosokawa
authors.forename: O
authors.initials: O
authors.lastname: Tagaya
authors.forename: Y
authors.initials: Y
authors.lastname: Nozaki
authors.forename: A
authors.initials: A
authors.lastname: Kawaguchi
authors.forename: H
authors.initials: H
authors.lastname: Funami
authors.forename: H
authors.initials: H
authors.lastname: Katoh
authors.forename: N
authors.initials: N
authors.lastname: Yamamoto
authors.forename: T
authors.initials: T
authors.lastname: Wakabayashi
mesh_terms: D000818:Animals; D001663:Bilirubin / Q000652:urine*; D005260:Female; D006933:Hyperbilirubinemia, Hereditary / Q000652:urine*; D008098:Litter Size; D008297:Male; D010641:Phenotype; D051381:Rats; D011922:Rats, Mutant Strains / Q000652:urine*
chemical_list: D001663:Bilirubin