title: Decreased latencies for limbic seizures induced in rats by lithium-pilocarpine occur when daily average geomagnetic activity exceeds 20 nanoTesla.
abstract: A decrease in the latency for the overt display of limbic seizures following the systemic injection of lithium and pilocarpine is weakly associated with enhanced global geomagnetic activity (in nanoTesla; nT). To determine the optimal threshold in global geomagnetic activity that is required for this effect, the seizure onset times for over 300 rats were dichotomized according to successive 5 nT increments. The results suggested that the seizure process occurred about 12% more quickly when the average daily global geomagnetic activity exceeded 20-25 nT and is commensurate with the observations by other researchers.
authors.affiliation: Behavioural Neuroscience Laboratory, Laurentian University, Sudbury, Ontario, Canada.
authors.forename: Y R
authors.initials: YR
authors.lastname: Bureau
authors.forename: M A
authors.initials: MA
authors.lastname: Persinger
mesh_terms: D000818:Animals; D004056:Differential Threshold; D018534:Earth, Planet; D008032:Limbic System / Q000503:physiopathology*; D008094:Lithium; D008280:Magnetics; D008297:Male; D010862:Pilocarpine; D051381:Rats; D017208:Rats, Wistar; D011930:Reaction Time; D012640:Seizures / Q000139:chemically induced / Q000503:physiopathology*
chemical_list: D010862:Pilocarpine; D008094:Lithium