title: A new cytogenetic subgroup in uterine leiomyoma is characterized by a deletion of the long arm of chromosome 3.
abstract: Our cytogenetic findings in 175 uterine leiomyomas revealed 52 tumors with clonal chromosome abnormalities, eight of which did not belong to any well-delineated cytogenetic abnormal subgroup. However, an interstitial deletion of the long arm of chromosome 3 was found, as the sole chromosome abnormality, in three cases. We believe that this involvement of 3q is significant enough to consider it as a new cytogenetic subgroup of uterine leiomyoma.
authors.affiliation: Center for Human Genetics, University of Leuven, Belgium.
authors.forename: P
authors.initials: P
authors.lastname: Dal Cin
authors.forename: P
authors.initials: P
authors.lastname: Moerman
authors.forename: J
authors.initials: J
authors.lastname: Deprest
authors.forename: I
authors.initials: I
authors.lastname: Brosens
authors.forename: H
authors.initials: H
authors.lastname: Van den Berghe
mesh_terms: D000328:Adult; D002893:Chromosomes, Human, Pair 3; D005260:Female; D017353:Gene Deletion; D006801:Humans; D007621:Karyotyping; D007889:Leiomyoma / Q000235:genetics*; D008875:Middle Aged; D014594:Uterine Neoplasms / Q000235:genetics*