Influence of purines on endothelial high energy phosphates.
It was demonstrated that extracellularly available adenosine, which is reported to protect the endothelium during ischaemia and reperfusion [8], is predominantly uptaken and salvaged by HUVECs, thereby enriching the adenine phosphate pool. In this way adenosine could contribute to a regeneration of metabolically disturbed cells via increasing the intracellular ATP. In contrast, all other purines offered can hardly be used by HUVECs to increase the pool of energy rich phosphates.
Griesmacher
A
A
Dept. of Cardiothoracic Surgery, University Hospital Vienna, Austria.
De Abreu
R A
RA
Müller
M M
MM
D000244:Adenosine Diphosphate / Q000378:metabolism; D000255:Adenosine Triphosphate / Q000378:metabolism; D002250:Carbon Radioisotopes; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000187:drug effects / Q000378:metabolism*; D004734:Energy Metabolism / Q000187:drug effects*; D006153:Guanosine Diphosphate / Q000378:metabolism; D006160:Guanosine Triphosphate / Q000378:metabolism; D006801:Humans; D011687:Purines / Q000378:metabolism* / Q000494:pharmacology*; D011865:Radioisotope Dilution Technique; D012265:Ribonucleotides / Q000494:pharmacology*; D014471:Umbilical Veins
D002250:Carbon Radioisotopes; D011687:Purines; D012265:Ribonucleotides; D006153:Guanosine Diphosphate; D000244:Adenosine Diphosphate; D006160:Guanosine Triphosphate; D000255:Adenosine Triphosphate