Mutagenicity testing of a rodenticide, zinctox (zinc phosphide) in a mouse in vivo system.
The genotoxic potential of zinctox (zinc phosphide) was evaluated in mice in vivo employing different bioassays: bone marrow chromosome aberration, micronucleus and sperm shape abnormality. A significant increase of chromosome aberrations was induced by three doses. Interestingly, the highest percentage was induced by the middle dose. In a route-responsive study the highest percentage of chromosome aberration was induced by the oral route. A dose-dependent increase in the incidence of micronuclei was noticed in the bone marrow cells. In the sperm shape abnormality test a high percentage of abnormal sperm was induced by all three dose levels. The results revealed the genotoxic potential of zinctox in the tested mouse in vivo system.
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P.G. Department of Zoology, Utkal University, Orissa, India.
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D000818:Animals; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002869:Chromosome Aberrations / Q000502:physiology*; D004305:Dose-Response Relationship, Drug; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects; D009152:Mutagenicity Tests; D010720:Phosphines / Q000494:pharmacology*; D012378:Rodenticides / Q000494:pharmacology*; D013077:Sperm Head / Q000187:drug effects; D017967:Zinc Compounds / Q000494:pharmacology*
D010720:Phosphines; D012378:Rodenticides; D017967:Zinc Compounds; C009701:zinc phosphide