title: [Monoamine oxidase activity in rat liver in vitamin B12 deficiency].
abstract: Changes in the activity of monoamine oxidase (MAO-B) in liver homogenates and mitochondria from normal and vitamin B12-deficient rats have been studied in various functional states of the mitochondria. Preincubation of liver preparation at 32 degrees C increased the MAO affinity for benzylamine in samples of normal (but not vitamin B12-deficient rats). Succinate added to the incubation medium decreased Km and increased Vmax in both normal and vitamin B12-deficient animals. A correlation was found between the decline of MAO-B activity under vitamin B12 deficiency, deceleration of succinate oxidation and reduction of the transmembrane potential.
authors.forename: N N
authors.initials: NN
authors.lastname: Gessler
authors.forename: N I
authors.initials: NI
authors.lastname: Fedotcheva
authors.forename: A G
authors.initials: AG
authors.lastname: Foĭgel'
authors.forename: N V
authors.initials: NV
authors.lastname: Alekseeva
authors.forename: M N
authors.initials: MN
authors.lastname: Kondrashova
authors.forename: V Ia
authors.initials: VIa
authors.lastname: Bykhovskiĭ
mesh_terms: D000818:Animals; D008099:Liver / Q000201:enzymology* / Q000503:physiopathology; D008297:Male; D008564:Membrane Potentials; D008995:Monoamine Oxidase / Q000378:metabolism*; D010084:Oxidation-Reduction; D051381:Rats; D017208:Rats, Wistar; D014805:Vitamin B 12 / Q000378:metabolism; D014806:Vitamin B 12 Deficiency / Q000201:enzymology* / Q000503:physiopathology
chemical_list: D008995:Monoamine Oxidase; D014805:Vitamin B 12
vernacular_title: Monoaminooksidaznaia aktivnost' v pecheni krys pri nedostatochnosti vitamina B12.