Macrosomic infants of nondiabetic mothers and elevated C-peptide levels in cord blood.
C-peptide concentrations in the cord blood of 29 macrosomic neonates born of nondiabetic mothers were higher than in 23 control infants whose birth weight was appropriate for gestational age, and there was a significant direct correlation between birth weight and C-peptide concentration. Six of the macrosomic infants studied (20%) had hypoglycemia in the first 24 hours of life, compared with none of the infants born with appropriate weight. We conclude that chronic fetal hyperinsulinemia may be one of the causes of macrosomia and neonatal hypoglycemia in infants of nondiabetic mothers.
Akinbi
H T
HT
Pennsylvania Hospital, Department of Pediatrics, University of Pennsylvania School of Medicine, Philadelphia 19107, USA.
Gerdes
J S
JS
D001724:Birth Weight; D002096:C-Peptide / Q000097:blood*; D016640:Diabetes, Gestational; D005260:Female; D005312:Fetal Blood / Q000737:chemistry*; D005320:Fetal Macrosomia / Q000097:blood*; D005865:Gestational Age; D006801:Humans; D007003:Hypoglycemia / Q000097:blood; D007231:Infant, Newborn; D011247:Pregnancy; D011863:Radioimmunoassay
D002096:C-Peptide