Pancreatic insulin-secreting carcinoma in a dog: fructosamine for determining persistent hypoglycaemia.
A five-year-old intact male rottweiler was presented with a history of episodic weakness and mild-generalised seizures. A tentative diagnosis of an insulin-secreting tumour in the pancreas was made based on fasting hypoglycaemia with concomitant hyperinsulinaemia and a subnormal fructosamine value. The diagnosis was confirmed by exploratory coeliotomy, intravenous infusion of methylene blue, histopathology and immuno-histochemical analysis of suspected neoplastic tissue. Fructosamine assays are traditionally used for monitoring the metabolic status of diabetics where a single elevated measurement reflects persistent hyperglycaemia. This report suggests that a single low measurement of fructosamine may indicate persistent hypoglycaemia and may be helpful, in conjunction with an insulin measurement, in the diagnosis of insulin-secreting tumours.
Thoresen
S I
SI
Norwegian College of Veterinary Medicine, Department of Small Animal Clinical Sciences, Oslo.
Aleksandersen
M
M
Lønaas
L
L
Bredal
W P
WP
Grøndalen
J
J
Berthelsen
K
K
D000818:Animals; D001786:Blood Glucose / Q000032:analysis; D002277:Carcinoma / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery / Q000662:veterinary*; D004283:Dog Diseases / Q000175:diagnosis* / Q000503:physiopathology / Q000601:surgery; D004285:Dogs; D019270:Fructosamine; D006595:Hexosamines / Q000378:metabolism*; D007003:Hypoglycemia / Q000175:diagnosis / Q000662:veterinary*; D007328:Insulin / Q000378:metabolism*; D000078790:Insulin Secretion; D008297:Male; D010190:Pancreatic Neoplasms / Q000175:diagnosis / Q000378:metabolism / Q000503:physiopathology / Q000601:surgery / Q000662:veterinary*; D011182:Postoperative Care / Q000662:veterinary; D013997:Time Factors
D001786:Blood Glucose; D006595:Hexosamines; D007328:Insulin; D019270:Fructosamine