Treatment of Lesch-Nyhan syndrome with AICAR.
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Department of Pediatrics, University of California, San Diego, La Jolla 92093, USA.
Barshop
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Yu
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Nyhan
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WL
D000293:Adolescent; D000620:Aminoimidazole Carboxamide / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000493:pharmacokinetics / Q000627:therapeutic use; D006801:Humans; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000097:blood / Q000652:urine; D007262:Infusions, Intravenous; D007926:Lesch-Nyhan Syndrome / Q000150:complications / Q000188:drug therapy* / Q000378:metabolism; D007938:Leukemia / Q000150:complications / Q000378:metabolism; D008297:Male; D010117:Oxypurinol / Q000652:urine; D012265:Ribonucleotides / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000627:therapeutic use*; D014527:Uric Acid / Q000097:blood / Q000652:urine; D019820:Xanthine; D014970:Xanthines / Q000097:blood / Q000652:urine
D007042:Hypoxanthines; D012265:Ribonucleotides; D014970:Xanthines; D019820:Xanthine; D014527:Uric Acid; D019271:Hypoxanthine; D000620:Aminoimidazole Carboxamide; C031143:AICA ribonucleotide; D010117:Oxypurinol