Time course and inhibition of stavaroside K, veratramine and cevine-induced hemolysis by other pregnane glycosides and Veratrum alkaloids.
Stavaroside K, veratramine and cevine induce hemolysis, whereas 7 other pregnane stavarosides and 8 Veratrum alkaloids are not hemolytic. On the other hand, erythrocytes pretreated or incubated with low concentrations of stavarosides D-F or with the 8 other Veratrum alkaloids were resistant to hemolysis induced by authentic saponin, stavaroside K, cevine or veratramine. Veratridine, zygadenine and angeloylzygadenine (the known Na-Channel-Gate toxins) revealed the most potent reduction of hemolytic activity.
Badria
F A
FA
Pharmacognosy Department, Faculty of Pharmacy, Mansoura University, Egypt.
McChesney
J D
JD
Halim
A F
AF
Zaghloul
A M
AM
el Sayed
K A
KA
D002595:Cevanes / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D004912:Erythrocytes / Q000187:drug effects; D005960:Glucosides / Q000037:antagonists & inhibitors* / Q000494:pharmacology; D006461:Hemolysis / Q000187:drug effects*; D006801:Humans; D066298:In Vitro Techniques; D011278:Pregnanes / Q000494:pharmacology*; D012503:Saponins / Q000494:pharmacology; D014704:Veratrum Alkaloids / Q000037:antagonists & inhibitors* / Q000494:pharmacology*
D002595:Cevanes; D005960:Glucosides; D011278:Pregnanes; D012503:Saponins; D014704:Veratrum Alkaloids; C095295:stavaroside K; C095294:cevine; C009649:veratramine