title: [Genetic aspects of BCG vaccination in experimental tuberculosis].
abstract: The paper discusses the genetic control of and the mechanisms of protective antituberculous immunity following BCG vaccination in inbred mice. The following genetic systems H-2 (B10.M)(H-2f) and B10.SM (H-2v) congenics were not protected with a high dose of BCG vaccine); Xid (X-linked immunodeficiency) CBA/N mice were not protected with regularly protective doses of BCG vaccine; Tbc-1 (I/St mice (Tbc-1s) were hypersensitive to tuberculosis. In two genetic systems (H-2 and xid), a distinct genetic control of susceptibility to primary tuberculosis and efficacy of BCG vaccination was demonstrated.
authors.forename: B V
authors.initials: BV
authors.lastname: Nikonenko
authors.forename: A S
authors.initials: AS
authors.lastname: Apt
authors.forename: M V
authors.initials: MV
authors.lastname: Mezhlumova
authors.forename: L E
authors.initials: LE
authors.lastname: Pospelov
authors.forename: A M
authors.initials: AM
authors.lastname: Moroz
mesh_terms: D000818:Animals; D001500:BCG Vaccine / Q000008:administration & dosage; D004198:Disease Susceptibility; D051379:Mice; D008806:Mice, Inbred AKR; D008809:Mice, Inbred C3H; D008808:Mice, Inbred CBA; D008815:Mice, Inbred Strains; D014376:Tuberculosis / Q000235:genetics* / Q000276:immunology / Q000517:prevention & control; D014611:Vaccination
chemical_list: D001500:BCG Vaccine
vernacular_title: Geneticheskie aspekty vaktsinatsii BCG pri éksperimental'nom tuberkuleze.