[Dopamine-D2 receptor scintigraphy with 123I-iodobenzofuran in malignant melanoma].
In recent publications dopamine-D2 receptor scintigraphy with benzamides was postulated for specific imaging of melanoma. In a prospective study the value of 123I-iodobenzofuran (IBF), a highly specific and affine dopamine-D2 receptor ligand was evaluated for the detection of melanoma metastases. With IBF-D2 receptor scintigraphy only 2 of 17 melanoma metastases could be detected. The interpretation of the abdomen was impaired by the hepatobiliary and renal excretion of the radionuclide. The ratio striatum/frontal cortex of 2.75 +/- 0.49 3 h p.i. demonstrated a high D2-receptor binding of the ligand. IBF-D2-receptor scintigraphy is not suitable as a method of staging melanoma.
Steinert
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Departement für Medizinische Radiologie, Universitätsspital Zürich, Schweiz.
Huch-Böni
R A
RA
Böni
R
R
Westera
G
G
Buck
A
A
D000328:Adult; D000368:Aged; D001572:Benzofurans / Q000378:metabolism; D001932:Brain Neoplasms / Q000000981:diagnostic imaging / Q000378:metabolism / Q000556:secondary*; D003342:Corpus Striatum / Q000000981:diagnostic imaging / Q000378:metabolism; D005260:Female; D005625:Frontal Lobe / Q000000981:diagnostic imaging / Q000378:metabolism; D006801:Humans; D007457:Iodine Radioisotopes; D008297:Male; D008545:Melanoma / Q000000981:diagnostic imaging* / Q000378:metabolism / Q000473:pathology / Q000556:secondary*; D008875:Middle Aged; D009362:Neoplasm Metastasis; D009367:Neoplasm Staging; D011446:Prospective Studies; D011877:Radionuclide Imaging; D017448:Receptors, Dopamine D2 / Q000032:analysis* / Q000378:metabolism; D012680:Sensitivity and Specificity
D001572:Benzofurans; D007457:Iodine Radioisotopes; D017448:Receptors, Dopamine D2
Dopamin-D2-Rezeptorszintigraphie mit 123I-Jodbenzofuran beim malignen Melanom.