[Properties of Na+/HCO3-(Cl-)-stimulated ATPase in rabbit small intestinal mucosa].
It has been demonstrated that histamine induces in rabbit small intestine an ATPase activity which is stimulated by NaCl or NaHCO3. The Na+/HCO3- (C1-)-stimulated ATPase activity, unlike the Mg2+,HCO3(-)-ATPase activity, has a pH optimum at pH 6.2, is inhibited by ethacrynic acid (10(-4) M) and bivalent metal ions (but not 10(-2) M thiocyanate). The substrate specificity of Na+/HCO3- (C1-)-ATPase and its regulation by Ca2+ ions has been studied. The feasible role of the enzyme in secretion is discussed.
Shubin
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VS
Iurkiv
V A
VA
D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors / Q000378:metabolism*; D000818:Animals; D002118:Calcium / Q000378:metabolism; D004789:Enzyme Activation; D004976:Ethacrynic Acid / Q000494:pharmacology; D006863:Hydrogen-Ion Concentration; D007413:Intestinal Mucosa / Q000201:enzymology*; D007421:Intestine, Small / Q000201:enzymology*; D008297:Male; D011817:Rabbits; D017693:Sodium Bicarbonate / Q000494:pharmacology*; D012965:Sodium Chloride / Q000494:pharmacology*; D013379:Substrate Specificity
D012965:Sodium Chloride; D017693:Sodium Bicarbonate; D000251:Adenosine Triphosphatases; D004976:Ethacrynic Acid; D002118:Calcium
Svoĭstva Na+/HCO3-(Cl-)-stimuliruemoĭ ATPazy slizistoĭ obolochki tonkogo kishechnika krolikov.