Intra-accumbens delta 1-opioid agonist, pC1-DPDPE, differentially affects patterns of locomotor activity.
The effects of bilateral microinjections of a new potent and highly selective delta-opioid receptor agonist pCl-DPDPE (0.00, 0.1, 1.0, or 2.5 micrograms/side) were tested in rats for 60 min in activity monitors. The durations of horizontal movement time, rearing time, and stereotypy time were measured during six consecutive 10-min time blocks. The pCl-DPDPE resulted in short-lived biphasic effects of attenuation followed by potentiation for the three measures. These data in part replicate the behavioral effects of other delta-opioid receptor agonists.
Meyer
M E
ME
Department of Psychology, University of Florida Gainesville 32611, USA.
McLaurin
B I
BI
Meyer
M E
ME
D000700:Analgesics / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D020881:Enkephalin, D-Penicillamine (2,5)-; D004745:Enkephalins / Q000008:administration & dosage / Q000494:pharmacology*; D007267:Injections; D008297:Male; D009043:Motor Activity / Q000187:drug effects*; D009714:Nucleus Accumbens / Q000033:anatomy & histology; D051381:Rats; D017465:Receptors, Opioid, delta / Q000819:agonists*; D013239:Stereotyped Behavior / Q000187:drug effects; D013997:Time Factors
D000700:Analgesics; D004745:Enkephalins; D017465:Receptors, Opioid, delta; D020881:Enkephalin, D-Penicillamine (2,5)-