title: Reduction of free fatty acids may ameliorate risk factors associated with abdominal obesity.
abstract: Experimental data as well as logical considerations suggest that the increased cardiovascular risk associated with abdominal obesity is mediated primarily by increased levels and flux of free fatty acids. Practical strategies for decreasing free fatty acid levels and/or flux may include: a very-low-fat, low-glycemic-index diet; promotion of insulin sensitivity (via exercise training, chromium, soluble fiber or drugs); anti-lipolytic agents; and stimulation of hepatic lipid oxidation with hydroxycitrate, carnitine and possibly fish omega-3s. Fortunately, many of these measures should also promote a leaner physique. Thus, even when abdominal obesity cannot be corrected, it may prove feasible to mitigate its dangers.
authors.affiliation: Nutrition 21, San Diego, CA 92109, USA.
authors.forename: M F
authors.initials: MF
authors.lastname: McCarty
mesh_terms: D000005:Abdomen; D000818:Animals; D002318:Cardiovascular Diseases / Q000453:epidemiology / Q000517:prevention & control; D018752:Diet, Fat-Restricted; D005230:Fatty Acids, Nonesterified / Q000378:metabolism; D006801:Humans; D000960:Hypolipidemic Agents / Q000627:therapeutic use; D007333:Insulin Resistance; D008099:Liver / Q000378:metabolism; D009765:Obesity / Q000178:diet therapy* / Q000503:physiopathology*; D012307:Risk Factors
chemical_list: D005230:Fatty Acids, Nonesterified; D000960:Hypolipidemic Agents