Iron, intracellular calcium ion, lipid peroxidation and carcino-genesis.
The evaluation of the accumulated experimental results on the action of complexed iron on cells indicates that the provoked cell injury is rather the consequence of an inhibition of the cytosolic Ca2+ concentration regulatory system than an effect of iron-induced lipid peroxidation. The role of the consequent intracellular ionic environment change in the preneoplastic and neoplastic transformation of the cell is discussed.
Anghileri
L J
LJ
Biophysics Laboratory, Medicine Faculty, University of Nancy, France.
D000818:Animals; D002118:Calcium / Q000378:metabolism*; D002471:Cell Transformation, Neoplastic; D006706:Homeostasis; D006801:Humans; D007501:Iron / Q000494:pharmacology*; D015227:Lipid Peroxidation
D007501:Iron; D002118:Calcium