Altered expression of the p50 subunit of the NF-kappa B transcription factor complex in non-small cell lung carcinoma.
Recent studies have implicated a role for the p50 subunit of the NF-kappa B transcription factor complex in tumorigenesis. Therefore, we investigated the expression of the p50 subunit of the NF-kappa B transcription factor complex in paired normal and non-small cell lung carcinoma (NSCLC) tissues. Here we show that nine of 11 (81.8%) fresh NSCLC tissues expressed from two- to 20-fold higher levels of the p50 subunit than normal lung tissue. Thirteen NSCLC cell lines also exhibited high levels of p50. Alterations in the normal NF-kappa B/rel pathway of regulation may play a role in the genesis of NSCLC.
Mukhopadhyay
T
T
Department of Thoracic and Cardiovascular Surgery, University of Texas M. D. Anderson Cancer Center, Houston 77030, USA.
Roth
J A
JA
Maxwell
S A
SA
D002289:Carcinoma, Non-Small-Cell Lung / Q000378:metabolism*; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D016328:NF-kappa B / Q000096:biosynthesis* / Q000235:genetics; D052002:NF-kappa B p50 Subunit; D012333:RNA, Messenger / Q000032:analysis; D014407:Tumor Cells, Cultured
D016328:NF-kappa B; D052002:NF-kappa B p50 Subunit; D012333:RNA, Messenger