Mechanisms underlying invasion and metastasis.
Despite continuing advances in the molecular characterization of the events promoting metastasis, no significant impact has been made on therapy or survival rates for patients with advanced tumors. Over the past 12 months there has been a general consolidation of the emerging evidence indicating that tumor spread is regulated by mechanisms involving disturbances in normal homeostatic processes. This review discusses these developments and also highlights the active role of peritumoral stroma in modulating invasion and spread of cancer.
Dorudi
S
S
Imperial Cancer Research Fund Laboratories, London, UK.
Hart
I R
IR
D002448:Cell Adhesion / Q000502:physiology; D002450:Cell Communication / Q000502:physiology; D004730:Endothelium, Vascular / Q000166:cytology; D006801:Humans; D009361:Neoplasm Invasiveness / Q000503:physiopathology*; D009362:Neoplasm Metastasis / Q000503:physiopathology*; D009369:Neoplasms / Q000473:pathology; D009389:Neovascularization, Pathologic / Q000503:physiopathology; D017154:Stromal Cells / Q000502:physiology