Comparison of plasma total plasmin activities in male and female hypertensive rats.
Plasma total plasmin activity in spontaneously hypertensive rats (SHR) was lower than in normal Wistar rats, and in male SHR, plasmin activity was higher than that in females. However, this sex-related difference in SHR was less than that observed in our previous study in normal Wistar rats. Furthermore, we and others have reported higher levels of coagulant functions in male than in female rats. These studies were taken to indicate that there is a greater necessity for higher fibrinolytic activity in males than in females. The results of the present study suggest that hypertension is a risk factor of thrombosis in view of the increased fibrinolytic activity, and in SHR there is also a sex-related difference in plasma total plasmin activity.
Kojima
T
T
Department of Pharmacology and Toxicology, Kanagawa Prefectural Public Health Laboratories, Japan.
Doi
K
K
Kishi
M
M
Horiguchi
Y
Y
D000595:Amino Acid Sequence; D000818:Animals; D005260:Female; D005341:Fibrinolysin / Q000032:analysis*; D005342:Fibrinolysis; D006973:Hypertension / Q000097:blood*; D008297:Male; D008969:Molecular Sequence Data; D051381:Rats; D011918:Rats, Inbred SHR; D017208:Rats, Wistar; D012737:Sex Factors
D005341:Fibrinolysin