Sudden sound-induced death in magnesium-deficient rats after repetitive episodes of seizures result from brain dysfunction.
To clarify the changes occurring in EEG and ECG from seizure induction to sudden death, 25 weanling male Sprague-Dawley rats were fed a severely Mg-deficient diet for 18 days. In nine of 25 Mg-deficient rats, both EEG and ECG were recorded from the beginning of seizures induction until sudden death. When flattening of EEG became after seizure occurrence, all nine Mg-deficient rats did not recover and death occurred within a few minutes. These results may support the idea that sudden death in Mg-deficient rats resulted from brain dysfunction after repetitive episodes of noise-induced seizures and not from simple apnoea due to tonic contraction of respiratory muscle.
Nakamura
M
M
Department of Clinical Nutrition, Graduate School of Health and Nutrition Sciences, Nakamura-Gakuen College, Fukuoka, Japan.
Abe
S
S
Goto
Y
Y
Chishaki
A
A
D000161:Acoustic Stimulation; D000818:Animals; D001835:Body Weight; D001927:Brain Diseases / Q000209:etiology*; D002118:Calcium / Q000097:blood; D003645:Death, Sudden / Q000209:etiology*; D004562:Electrocardiography; D004569:Electroencephalography; D008274:Magnesium / Q000097:blood; D008275:Magnesium Deficiency / Q000150:complications* / Q000503:physiopathology; D008297:Male; D011188:Potassium / Q000097:blood; D051381:Rats; D017207:Rats, Sprague-Dawley; D012640:Seizures / Q000209:etiology*; D012964:Sodium / Q000097:blood
D012964:Sodium; D008274:Magnesium; D011188:Potassium; D002118:Calcium