title: A PC-based graphical simulator for physiological pharmacokinetic models.
abstract: Since many intravenous anesthetic drugs alter blood flows, physiologically-based pharmacokinetic models describing drug disposition may be time-varying. Using the commercially available programming software MATLAB, a platform to simulate time-varying physiological pharmacokinetic models was developed. The platform is based upon a library of pharmacokinetic blocks which mimic physiological structure. The blocks can be linked together flexibly to form models for different drugs. Because of MATLAB's additional numerical capabilities (e.g. non-linear optimization), the platform provides a complete graphical microcomputer-based tool for physiologic pharmacokinetic modeling.
authors.affiliation: Stanford University, Department of Anesthesia, CA 94305-5117, USA.
authors.forename: D R
authors.initials: DR
authors.lastname: Wada
authors.forename: D R
authors.initials: DR
authors.lastname: Stanski
authors.forename: W F
authors.initials: WF
authors.lastname: Ebling
mesh_terms: D000777:Anesthetics / Q000493:pharmacokinetics; D000818:Animals; D003196:Computer Graphics; D003198:Computer Simulation; D006801:Humans; D008838:Microcomputers; D008954:Models, Biological; D010599:Pharmacokinetics; D010827:Physiology; D012984:Software; D014018:Tissue Distribution
chemical_list: D000777:Anesthetics