Capnocytophaga (Capnocytophaga ochracea group) bacteremia in hematological patients with profound granulocytopenia.
The clinical and microbiological features of 7 cases of bacteremia due to Capnocytophaga (Capnocytophaga ochracea group) are reported. They were diagnosed during 1991-93 at three hospital clinics. Five patients were < 10 years old and all had hematological disorders, 4 acute lymphoblastic leukemia and 1 each had aplastic anemia, non-Hodgkin lymphoma, and myelodysplastic syndrome. All were profoundly granulocytopenic with an absolute granulocyte count < 0.13 x 10(9)/l, and all but 1 had oral lesions as a possible portal of entry. A favourable response to antibiotic therapy was recorded in all patients but one who, being profoundly granulocytopenic, rapidly succumbed to Pseudomonas aeruginosa septicemia. None of the isolates were beta-lactamase producers. In addition to penicillin the isolates were susceptible to broad-spectrum cephalosporins and ciprofloxacin, but resistant to aminoglycosides.
Kristensen
B
B
Department of Clinical Microbiology, Aalborg Hospital, Denmark.
Schønheyder
H C
HC
Peterslund
N A
NA
Rosthøj
S
S
Clausen
N
N
Frederiksen
W
W
D000293:Adolescent; D000368:Aged; D000380:Agranulocytosis / Q000150:complications*; D000900:Anti-Bacterial Agents; D016470:Bacteremia / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D002206:Capnocytophaga / Q000302:isolation & purification; D002648:Child; D002675:Child, Preschool; D004359:Drug Therapy, Combination / Q000627:therapeutic use; D005260:Female; D016905:Gram-Negative Bacterial Infections / Q000150:complications* / Q000175:diagnosis / Q000188:drug therapy; D006098:Granulocytes / Q000276:immunology; D006402:Hematologic Diseases / Q000150:complications*; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D009059:Mouth Diseases / Q000150:complications; D009061:Mouth Mucosa / Q000382:microbiology; D011379:Prognosis
D000900:Anti-Bacterial Agents