A bioactive tetraprenylphenol from Lactarius lignyotus.
2-Geranylgeranyl-1,4-dihydroxybenzene [1] and a mixture of fatty acid esters of this phenol were isolated from the fruiting bodies of Lactarius lignyotus. Compound 1 was highly active in the brine shrimp test and showed significant inhibitory activity on DNA, RNA, and protein synthesis in HeLa and HL-60 cell lines.
Vidari
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G
Dipartimento di Chimica Organica, Università di Pavia, Italy.
Vita-Finzi
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P
Zanocchi
A M
AM
Noy
G P
GP
D001487:Basidiomycota / Q000737:chemistry*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004224:Diterpenes; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007930:Leucine / Q000378:metabolism; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014529:Uridine / Q000378:metabolism
D004273:DNA, Neoplasm; D004224:Diterpenes; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D013729:Terpenes; C026300:geranylgeranylhydroquinone; D007930:Leucine; D013936:Thymidine; D014529:Uridine