Translational regulation: versatile mechanisms for metabolic and developmental control.
It has become clear that many vital metabolic circuits and early developmental programs are regulated translationally. Until recently, the mechanisms underlying most of these observations were poorly understood. The past year has witnessed several important advances in the understanding of how the translational apparatus is controlled by different regulatory mechanisms.
Hentze
M W
MW
Gene Expression Programme, European Molecular Biology Laboratory, Heidelberg, Germany.
D000818:Animals; D003593:Cytoplasm / Q000378:metabolism; D015852:Eukaryotic Initiation Factor-2 / Q000235:genetics / Q000378:metabolism; D039561:Eukaryotic Initiation Factor-4E; D018507:Gene Expression Regulation, Developmental; D006801:Humans; D016366:Open Reading Frames; D010448:Peptide Initiation Factors / Q000235:genetics / Q000378:metabolism; D014176:Protein Biosynthesis; D012315:RNA Caps / Q000235:genetics / Q000378:metabolism; D012333:RNA, Messenger / Q000235:genetics / Q000378:metabolism; D016601:RNA-Binding Proteins / Q000378:metabolism
D015852:Eukaryotic Initiation Factor-2; D039561:Eukaryotic Initiation Factor-4E; D010448:Peptide Initiation Factors; D012315:RNA Caps; D012333:RNA, Messenger; D016601:RNA-Binding Proteins