Antimutagenic efficacy of higher doses of vitamin C.
Vitamin C, when administered concurrently with a pesticide (endosulfan, phosphamidon or mancozeb), could significantly decrease the frequency of pesticide-induced clastogenic and mitosis-disruptive changes in the bone marrow cells of young Swiss albino mice. Of the three doses (10, 20 or 40 mg/kg b.wt./day) of the vitamin, the one which is double the human therapeutic dose (20 mg/kg b.wt./day) was most effective as an antimutagen to be followed by 40 mg and 10 mg. None of these doses of vitamin C showed any genotoxicity of their own for the parameters studied here.
Khan
P K
PK
Department of Zoology, Bhagalpur University, India.
Sinha
S P
SP
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D001205:Ascorbic Acid / Q000008:administration & dosage*; D001854:Bone Marrow Cells; D002869:Chromosome Aberrations; D004726:Endosulfan / Q000037:antagonists & inhibitors; D008344:Maneb / Q000037:antagonists & inhibitors; D051379:Mice; D008815:Mice, Inbred Strains; D008938:Mitosis / Q000187:drug effects; D016296:Mutagenesis / Q000187:drug effects*; D010707:Phosphamidon / Q000037:antagonists & inhibitors; D015038:Zineb / Q000037:antagonists & inhibitors
D016587:Antimutagenic Agents; D008344:Maneb; D010707:Phosphamidon; D004726:Endosulfan; D001205:Ascorbic Acid; C013099:mancozeb; D015038:Zineb