Surface modification of albumin microspheres.
Submicron sized hydrophobic and hydrophilic albumin microspheres (MS) were prepared using a chemical crosslinking technique. Spermine was linked to the surface of the hydrophilic MS. The degree of hydrophobicity for these three types of MS was investigated using a novel technique of sedimentation volume. The surface tension of the hydrophobic MS was 31 mN m-1. The ST of the hydrophilic MS was 68 mN m-1, whereas the surface tension of spermine-linked MS corresponded to 62, 65.5, 69 and 71 mN m-1 indicating heterogeneous hydrophilic characteristics. Ligands can be successfully linked to MS using a water-soluble carbodiimide.
Shafi
Z B
ZB
Department of Pharmacy, University of Brighton, Moulescoomb, E. Sussex.
Martin
G P
GP
Olliff
C J
CJ
James
S L
SL
D000418:Albumins / Q000737:chemistry*; D002264:Carboxylic Acids / Q000737:chemistry; D007408:Intestinal Absorption; D008024:Ligands; D008863:Microspheres; D010316:Particle Size; D013096:Spermine / Q000737:chemistry; D013499:Surface Properties; D013500:Surface Tension
D000418:Albumins; D002264:Carboxylic Acids; D008024:Ligands; D013096:Spermine