title: [A case of toxoplasmic chorioretinitis and meningoencephalitis in an immunocompetent adult].
abstract: A 71-year-old man who presented with toxoplasmic chorioretinitis and meningoencephalitis is reported. He had been healthy and immunologically normal. Initially, he complained of blurring of vision without headache, nor fever. Neurological examinations revealed papilledema, nuchal rigidity, and disorientation. Fluorescent angiography of the ocular fundi disclosed hyperfluorescent leaks suggesting chrioretinitis. His EEG had dysrhythmic slow alpha wave with some theta slowing. CSF studies showed pleocytosis up to 80/mm3; the cells were predominantly lymphocytes. The titers of toxoplasma antibody in the serum and CSF were prominently increased. Toxoplasmosis was highly suspected and he was treated with predinsolone, acetylspiramycin, and pyrimethamine. After the treatment, ophthalmologic and neurological symptoms improved, and the laboratory findings including the titers of toxoplasma antibody in the serum and CSF were also improved. Recently, toxoplasmosis associated with neurological complications as an opportunistic infection is a serious problem in the immunocompromised hosts, especially in AIDS, but this infection is rare in immunologically normal adults. Our case and some other reports may suggest a chance of developing toxoplasmic meningoencephalitis even in healthy individuals. We have to think of the possibility of toxoplasmosis in the immunocompetent hosts when they are presenting with chorioretinitis and meningoencephalitis.
authors.affiliation: Department of Neurology, Kofu City Hospital.
authors.forename: M
authors.initials: M
authors.lastname: Waragai
authors.forename: Y
authors.initials: Y
authors.lastname: Takaya
authors.forename: M
authors.initials: M
authors.lastname: Hayashi
mesh_terms: D000368:Aged; D002825:Chorioretinitis / Q000209:etiology* / Q000276:immunology; D006801:Humans; D007121:Immunocompetence; D008297:Male; D008590:Meningoencephalitis / Q000209:etiology* / Q000276:immunology; D014123:Toxoplasmosis / Q000150:complications*