Topical delivery of growth hormone releasing peptide using liposomal systems: an in vitro study using hairless mouse skin.
The results of this study clearly demonstrates the utility of novel non-ionic liposomal systems in facilitating transfer of GHRP-6 into and across deeper strata of skin following topical application. These findings indicate that it may be possible to deliver therapeutic doses of a wide variety of peptides to local skin tissue via topical application. The results also suggest the possibility of controlled enhancement of skin penetration or metered polypeptide deposition through appropriate choice of liposomal lipid components. The pronounced enhancement of GHRP-6 and mannitol transport from emulsions containing the nonionic lipids suggests a promising delivery system for hydrophilic drugs in general.
Fleisher
D
D
College of Pharmacy, University of Michigan, Ann Arbor 48109, USA.
Niemiec
S M
SM
Oh
C K
CK
Hu
Z
Z
Ramachandran
C
C
Weiner
N
N
D000279:Administration, Cutaneous; D000595:Amino Acid Sequence; D000818:Animals; D004337:Drug Carriers; D066298:In Vitro Techniques; D008081:Liposomes; D051379:Mice; D008812:Mice, Hairless; D008969:Molecular Sequence Data; D009842:Oligopeptides / Q000008:administration & dosage*; D012867:Skin / Q000378:metabolism*; D012869:Skin Absorption
D004337:Drug Carriers; D008081:Liposomes; D009842:Oligopeptides; C041048:growth hormone releasing hexapeptide