Altered expression of class I HLA antigen on peripheral mononuclear cells in patients with adult T-cell leukemia: inverse relationship with natural killer susceptibility.
Patients with adult T-cell leukemia showed altered expression of class I HLA antigen in their peripheral blood lymphocytes. Acute type adult T-cell leukemia showed increased levels of the antigen expression compared to those of control group and smoldering type (P < 0.001 and 0.01, respectively). Natural killer sensitivity of infected cell lines with different levels of class I HLA expression showed an inverse relationship with the antigen expression. Further, various cell lines including human T-cell leukemia virus type I-infected cell lines treated with acid buffer, which selectively eliminated the surface class I HLA molecules from cell membrane, became more sensitive to natural killer-mediated lysis. These data suggested that the enhanced expression of class I HLA on peripheral blood lymphocytes of patients with acute type adult T-cell leukemia may contribute to escaping from the immunosurveillance system of natural killer cells in vivo.
Uno
H
H
Second Department of Internal Medicine, Miyazaki Medical School, Japan.
Matsuoka
H
H
Suzuki
M
M
Tsuda
K
K
Tsubouchi
H
H
D000328:Adult; D002460:Cell Line; D002470:Cell Survival; D006680:HLA Antigens / Q000096:biosynthesis* / Q000276:immunology; D015395:Histocompatibility Antigens Class I / Q000096:biosynthesis / Q000276:immunology; D015368:Human T-lymphotropic virus 1 / Q000276:immunology; D006801:Humans; D007694:Killer Cells, Natural / Q000276:immunology*; D015458:Leukemia, T-Cell / Q000276:immunology* / Q000821:virology; D007963:Leukocytes, Mononuclear / Q000276:immunology*; D011233:Precipitin Tests
D006680:HLA Antigens; D015395:Histocompatibility Antigens Class I