title: Tissue-specific expression of a Drosophila calcium-activated potassium channel.
abstract: The Drosophila slowpoke (slo) gene encodes a subunit of a CAK channel homologous to the vertebrate BK channel. We have examined slo expression throughout development. It is expressed in muscle cells, neurons of the CNS and PNS, mushroom bodies, a limited number of cells in embryonic and larval midgut and in epithelial-derived tracheal cells. The promoter has been cloned and shown to direct expression in the same pattern as the endogenous gene in both neural and epithelial-derived cells. During pupariation and embryogenesis, slo is expressed in muscles many hours prior to the appearance of functional channels.
authors.affiliation: Department of Zoology, University of Texas at Austin 78712-1064, USA.
authors.forename: M N
authors.initials: MN
authors.lastname: Becker
authors.forename: R
authors.initials: R
authors.lastname: Brenner
authors.forename: N S
authors.initials: NS
authors.lastname: Atkinson
mesh_terms: D000818:Animals; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000502:physiology*; D004064:Digestive System / Q000378:metabolism; D004330:Drosophila / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007814:Larva / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D015221:Potassium Channels / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D011679:Pupa / Q000378:metabolism; D014018:Tissue Distribution; D014132:Trachea / Q000166:cytology / Q000378:metabolism
chemical_list: D015221:Potassium Channels; D002118:Calcium