title: Structure and developmental regulation of Golli-mbp, a 105-kilobase gene that encompasses the myelin basic protein gene and is expressed in cells in the oligodendrocyte lineage in the brain.
abstract: We have identified a novel transcription unit of 105 kilobases (called the Golli-mbp gene) that encompasses the mouse myelin basic protein (MBP) gene. Three unique exons within this gene are alternatively spliced into MBP exons and introns to produce a family of MBP gene-related mRNAs that are under individual developmental regulation. These mRNAs are temporally expressed within cells of the oligodendrocyte lineage at progressive stages of differentiation. Thus, the MBP gene is a part of a more complex gene structure, the products of which may play a role in oligodendrocyte differentiation prior to myelination. One Golli-mbp mRNA that encodes a protein antigenically related to MBP is also expressed in the spleen and other non-neural tissues.
authors.affiliation: Mental Retardation Research Center, UCLA School of Medicine 90024.
authors.forename: A T
authors.initials: AT
authors.lastname: Campagnoni
authors.forename: T M
authors.initials: TM
authors.lastname: Pribyl
authors.forename: C W
authors.initials: CW
authors.lastname: Campagnoni
authors.forename: K
authors.initials: K
authors.lastname: Kampf
authors.forename: S
authors.initials: S
authors.lastname: Amur-Umarjee
authors.forename: C F
authors.initials: CF
authors.lastname: Landry
authors.forename: V W
authors.initials: VW
authors.lastname: Handley
authors.forename: S L
authors.initials: SL
authors.lastname: Newman
authors.forename: B
authors.initials: B
authors.lastname: Garbay
authors.forename: K
authors.initials: K
authors.lastname: Kitamura
mesh_terms: D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D001921:Brain / Q000166:cytology / Q000196:embryology / Q000378:metabolism*; D002478:Cells, Cultured; D004247:DNA; D005786:Gene Expression Regulation; D051379:Mice; D008807:Mice, Inbred BALB C; D008969:Molecular Sequence Data; D004676:Myelin Basic Protein / Q000235:genetics*; D009836:Oligodendroglia / Q000378:metabolism*; D012333:RNA, Messenger / Q000378:metabolism
chemical_list: D004676:Myelin Basic Protein; D012333:RNA, Messenger; D004247:DNA