Protein design: novel metal-binding sites.
In natural proteins, metal ions play a variety of roles, including nucleophilic catalysis, electron transfer and the stabilization of protein structure. The de novo design of metal-binding sites is therefore an attractive means by which to impart proteins with novel properties and activities.
Regan
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Yale University Department of Molecular Biophysics and Biochemistry, New Haven, CT 06520, USA.
D001665:Binding Sites; D003035:Cobalt / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D006639:Histidine / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D008958:Models, Molecular; D011487:Protein Conformation; D015202:Protein Engineering; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
D008670:Metals; D011506:Proteins; D003035:Cobalt; D006639:Histidine; D003300:Copper; D015032:Zinc