[The efficacy of cyclosporin in the treatment of myositis].
Cyclosporin A (CyA) was used in 15 patients with corticosteroid-resistant myositis (11) and as a first-line drug (4). The criterion for improvement was recovery of strength. Additionally, changes in muscle enzyme values were evaluated. One patient left therapy because of gastric intolerance. Another patient, with severe pulmonary fibrosis, died 6 days after initiating therapy. In the other patients a favorable response was observed at approximately six weeks (range 3 weeks-3 months). Significant decreases in muscle enzyme values were observed. CyA was useful for treatment of corticosteroid-resistant patients. While it was efficient as a first line drug, the present report does not allow a comparative evaluation with corticosteroid therapy.
Sánchez Román
J
J
Unidad de Colagenosis (Servicio de Medicina Interna), Hospital Universitario Virgen del Rocío, Sevilla.
Castillo Palma
M J
MJ
Ocaña Medina
C
C
Wichmann
I
I
Chinchón Lara
I
I
Segura Ayestarán
D I
DI
D000328:Adult; D000368:Aged; D002648:Child; D002908:Chronic Disease; D016572:Cyclosporine / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009132:Muscles / Q000187:drug effects / Q000201:enzymology; D009220:Myositis / Q000145:classification / Q000188:drug therapy* / Q000201:enzymology; D012074:Remission Induction; D013997:Time Factors
D016572:Cyclosporine
Eficacia de la ciclosporina en el tratamiento de las miositis.