Gonadotropin-releasing hormone agonist (GnRH-A) in hirsutism.
Twenty-five women presenting moderate-severe PCOS-dependant hirsuitism were treated for 6 months with GnRH-A (Group A) or pill-combined and GnRH (Group B). Both therapeutic regimens significantly decreased androgen plasma levels. Hair diameter reduced in Group A by 22-34% and in Group B by 25-35%, while hirsuitism score respectively decreased by 22 and 24%. Clinical results, overlapping in the two groups, prove that GnRH-A are active in hirsuitism. Side effects, however, especially a decreased bone density (3.9%) in Group A make it necessary an association with oral contraceptive.
Falsetti
L
L
Department of Gynecological Endocrinology, University of Brescia, Italy.
Pasinetti
E
E
Ceruti
D
D
D000328:Adult; D000728:Androgens / Q000097:blood; D015519:Bone Density / Q000187:drug effects; D003277:Contraceptives, Oral, Combined / Q000008:administration & dosage; D017373:Cyproterone Acetate / Q000008:administration & dosage; D004997:Ethinyl Estradiol / Q000008:administration & dosage; D005260:Female; D005640:Follicle Stimulating Hormone / Q000097:blood; D006197:Hair / Q000254:growth & development; D006628:Hirsutism / Q000097:blood / Q000188:drug therapy* / Q000209:etiology; D006801:Humans; D016729:Leuprolide / Q000009:adverse effects / Q000494:pharmacology / Q000627:therapeutic use*; D007986:Luteinizing Hormone / Q000097:blood; D011085:Polycystic Ovary Syndrome / Q000150:complications; D011388:Prolactin / Q000097:blood; D012720:Severity of Illness Index; D012738:Sex Hormone-Binding Globulin / Q000032:analysis
D000728:Androgens; D003277:Contraceptives, Oral, Combined; D012738:Sex Hormone-Binding Globulin; D004997:Ethinyl Estradiol; D017373:Cyproterone Acetate; D011388:Prolactin; D007986:Luteinizing Hormone; D005640:Follicle Stimulating Hormone; D016729:Leuprolide