The protective effect of moclobemide against hypoxia-induced lethality in mice is not due to a decrease in body temperature.
The protective effect of moclobemide, a reversible and highly selective inhibitor of monoamine oxidase-A, against hypoxia-induced lethality was investigated in the present experiment. Moclobemide showed an apparent protective potency against hypoxia and significantly prolonged the latencies for convulsions and death in a dose-dependent manner. Hypothermia is known to protect animals from hypoxia. Moclobemide also decreased body temperature in mice; however, the hypothermic effect was unrelated to the antihypoxic effect. These results suggest that the protective effect of moclobemide in hypoxia is not due to a decrease in body temperature.
Ulugol
A
A
Department of Pharmacology, Faculty of Medicine, Trakya University, Turkey.
Karadag
H C
HC
Dokmeci
D
D
al-Khatib
I
I
Dokmeci
I
I
D000818:Animals; D000927:Anticonvulsants / Q000627:therapeutic use*; D001549:Benzamides / Q000627:therapeutic use*; D001831:Body Temperature / Q000187:drug effects*; D004305:Dose-Response Relationship, Drug; D000860:Hypoxia / Q000188:drug therapy* / Q000503:physiopathology; D008297:Male; D051379:Mice; D020912:Moclobemide; D012640:Seizures / Q000503:physiopathology
D000927:Anticonvulsants; D001549:Benzamides; D020912:Moclobemide