title: Reduction of adhesion reformation after laparoscopic endometriosis surgery: a randomized trial with an oxidized regenerated cellulose absorbable barrier.
abstract: OBJECTIVE
  To evaluate the effectiveness of an oxidized regenerated cellulose absorbable barrier (Interceed [TC7] Absorbable Adhesion Barrier) in the reduction of adhesion reformation after laparoscopic surgery for endometriosis.
  
  
  METHODS
  Thirty-two premenopausal nonpregnant women who had severe endometriosis and complete posterior cul-de-sac obliteration and were undergoing laparoscopic surgery were randomly assigned to either surgery alone or surgery and Interceed. None of the subjects received any other treatment for adhesion prevention. Second-look laparoscopy was performed 12-14 weeks after laparoscopic surgery by an investigator blinded to the treatment, and the incidence of adhesion-free subjects was assessed.
  
  
  RESULTS
  Twelve of 16 (75%) women treated with the oxidized regenerated cellulose barrier were free of adhesions, compared with two of 16 (12.5%) controls, a statistically significant difference (P < .05).
  
  
  CONCLUSIONS
  The oxidized regenerated cellulose absorbable barrier significantly reduces adhesion reformation after laparoscopic surgery for endometriosis.
authors.affiliation: Department of Obstetrics and Gynecology, University of Cagliari, Italy.
authors.forename: V
authors.initials: V
authors.lastname: Mais
authors.forename: S
authors.initials: S
authors.lastname: Ajossa
authors.forename: D
authors.initials: D
authors.lastname: Marongiu
authors.forename: R F
authors.initials: RF
authors.lastname: Peiretti
authors.forename: S
authors.initials: S
authors.lastname: Guerriero
authors.forename: G B
authors.initials: GB
authors.lastname: Melis
mesh_terms: D000328:Adult; D002483:Cellulose, Oxidized / Q000627:therapeutic use*; D004715:Endometriosis / Q000601:surgery*; D005260:Female; D005831:Genital Diseases, Female / Q000209:etiology / Q000517:prevention & control; D006801:Humans; D010535:Laparoscopy / Q000009:adverse effects*; D012008:Recurrence; D012086:Reoperation; D016037:Single-Blind Method; D000267:Tissue Adhesions / Q000209:etiology / Q000517:prevention & control
chemical_list: D002483:Cellulose, Oxidized; C060002:INTERCEED