Smoldering gamma delta T-cell granular lymphocytic leukemia associated with pure red cell aplasia.
We present a case of granular lymphocytic leukemia (GLL) associated with pure red cell aplasia (PRCA). Twenty-seven percent of the peripheral blood mononuclear cells (PBMC) were positive for TCR delta 1, but not for delta TCS1 (V delta 2), and a rearrangement of the TCR chain (J delta 1) gene was detected. The PBMC and serum from the patient slightly suppressed CFU-E but not BFU-E colony formation in vitro. These findings suggest that monoclonal proliferation of TCR gamma delta-positive granular lymphocytes (GL) can be associated with PRCA even in a patient having a small proportion of leukemia GL, which we propose to designate as 'smoldering GLL'.
Mori
S
S
Second Department of Internal Medicine, Kumamoto University School of Medicine, Japan.
Suzushima
H
H
Nishikawa
K
K
Miyake
H
H
Yonemura
Y
Y
Tsuji
N
N
Kawaguchi
T
T
Asou
N
N
Kawakita
M
M
Takatsuki
K
K
D003114:Colony-Forming Units Assay; D004906:Erythrocyte Count; D015672:Erythroid Precursor Cells; D005455:Fluorescent Antibody Technique; D015329:Gene Rearrangement, T-Lymphocyte; D006801:Humans; D007945:Leukemia, Lymphoid / Q000150:complications* / Q000276:immunology; D015458:Leukemia, T-Cell / Q000150:complications*; D007963:Leukocytes, Mononuclear / Q000276:immunology; D008297:Male; D008875:Middle Aged; D016692:Receptors, Antigen, T-Cell, gamma-delta / Q000032:analysis* / Q000235:genetics; D012010:Red-Cell Aplasia, Pure / Q000150:complications*
D016692:Receptors, Antigen, T-Cell, gamma-delta