title: Central retinal vein thrombosis associated with resistance to activated protein C.
abstract: OBJECTIVE
  Activated protein C resistance was recently described as a major cause of venous thrombosis. We observed a central retinal vein thrombosis in a woman with activated protein C resistance.
  
  
  CONCLUSIONS
  DNA analysis showed the patient to be heterozygous for the factor V gene mutation, which is related to activated protein C resistance. Patients with retinal vein thrombosis should be examined for activated protein C resistance.
authors.affiliation: Service de Médecine Interne, Hôpital Cochin, Paris, France.
authors.forename: R
authors.initials: R
authors.lastname: Dhôte
authors.forename: C
authors.initials: C
authors.lastname: Bachmeyer
authors.forename: M H
authors.initials: MH
authors.lastname: Horellou
authors.forename: P
authors.initials: P
authors.lastname: Toulon
authors.forename: B
authors.initials: B
authors.lastname: Christoforov
mesh_terms: D004252:DNA Mutational Analysis; D005165:Factor V / Q000235:genetics*; D005260:Female; D020022:Genetic Predisposition to Disease; D006493:Heparin / Q000627:therapeutic use; D006801:Humans; D008875:Middle Aged; D017354:Point Mutation; D011486:Protein C / Q000235:genetics / Q000502:physiology*; D011655:Pulmonary Embolism / Q000235:genetics; D012170:Retinal Vein Occlusion / Q000235:genetics* / Q000628:therapy; D013924:Thrombophlebitis / Q000235:genetics
chemical_list: D011486:Protein C; D005165:Factor V; D006493:Heparin