[Effect of brain angiotensin II on LH release].
Renin-angiotensin system is present in brain and independent of the peripheral renin-angiotensin system. The effect of brain angiotensin II (A II) on LH release is: (1) Ovarian steroids affect the direction of the LH responses to brain exogenous A II. In the absence of estradiol and progesterone, A II inhibits pulsatile LH release, whereas after treatment with estrogen, A II does not modify LH level. In animals pretreated with both estradiol benzoate and progesterone, exogenous A II stimulated the release of LH; (2) Brain endogenous A II may be involved in the preovulatory release of LH on proestrus; (3) A II affects LH secretion via LH-RH and norepinephrine in the brain.
Wang
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State Key Laboratory of Reproductive Biology, Chinese Academy of Sciences, Beijing.
D000804:Angiotensin II / Q000494:pharmacology / Q000502:physiology*; D000818:Animals; D001921:Brain / Q000378:metabolism*; D007987:Gonadotropin-Releasing Hormone / Q000378:metabolism; D007986:Luteinizing Hormone / Q000378:metabolism*; D012084:Renin-Angiotensin System / Q000502:physiology
D000804:Angiotensin II; D007987:Gonadotropin-Releasing Hormone; D007986:Luteinizing Hormone