title: Randomized trial of FK 506/prednisone vs FK 506/azathioprine/prednisone after renal transplantation: preliminary report.
abstract: FK 506 was used as a primary immunosuppressive agent in 125 cases of renal transplantation in a randomized trial comparing FK 506/prednisone with FK 506/azathioprine/prednisone. With a mean follow-up of 5.5 +/- 2.5 months, there has been a 6-month actuarial patient survival of 99% and graft survival of 88%. There is no difference thus far between the two-drug and three-drug groups, although there may be less rejection and diabetes in the three-drug group. These results suggest that FK 506 is a useful immunosuppressive agent in kidney transplantation.
authors.affiliation: Department of Surgery, University of Pittsburgh Health Science Center, Pennsylvania.
authors.forename: R
authors.initials: R
authors.lastname: Shapiro
authors.forename: M L
authors.initials: ML
authors.lastname: Jordan
authors.forename: V P
authors.initials: VP
authors.lastname: Scantlebury
authors.forename: J J
authors.initials: JJ
authors.lastname: Fung
authors.forename: C
authors.initials: C
authors.lastname: Jensen
authors.forename: C
authors.initials: C
authors.lastname: Vivas
authors.forename: J
authors.initials: J
authors.lastname: McCauley
authors.forename: W D
authors.initials: WD
authors.lastname: Irish
authors.forename: S
authors.initials: S
authors.lastname: Mitchell
authors.forename: A J
authors.initials: AJ
authors.lastname: Demetris
mesh_terms: D000206:Actuarial Analysis; D000328:Adult; D001379:Azathioprine / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D005500:Follow-Up Studies; D006084:Graft Rejection; D006085:Graft Survival; D006801:Humans; D007677:Kidney Function Tests; D016030:Kidney Transplantation / Q000276:immunology* / Q000473:pathology / Q000502:physiology; D011241:Prednisone / Q000627:therapeutic use*; D016019:Survival Analysis; D016559:Tacrolimus / Q000627:therapeutic use*
chemical_list: D001379:Azathioprine; D011241:Prednisone; D016559:Tacrolimus