title: Heterocyclizations under Vilsmeier conditions: an old method with interesting possibilities in drug research.
abstract: The Vilsmeier reaction is well known and widely used in substituting activated hydrogen with a formyl group into a great variety of molecules. This reaction is also a powerful synthetic tool used to obtain many heterocycle compounds, which may be difficult to reach or at times inaccessible. The more relevant data published in chemical literature in the last ten years and my personal experience are reported in the following with the aim of showing the valuable synthetic potential of this reaction.
authors.affiliation: Istituto di Scienze Farmaceutiche, Università di Genova.
authors.forename: A
authors.initials: A
authors.lastname: Balbi
mesh_terms: D000276:Adjuvants, Immunologic / Q000138:chemical synthesis / Q000494:pharmacology; D003500:Cyclization; D015870:Gene Expression / Q000187:drug effects; D006571:Heterocyclic Compounds / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology
chemical_list: D000276:Adjuvants, Immunologic; D006571:Heterocyclic Compounds