Ocular surface abnormalities in aniridia.
OBJECTIVE
The purpose of this study was to examine ocular surface abnormalities in aniridia.


METHODS
We prospectively studied the ocular surface in nine consecutive patients (18 eyes) with virtually total aniridia. Of the 18 eyes, two eyes (two patients) were excluded from the study because severe surgical damage was likely to be the main cause of their corneal abnormalities. Six volunteers whose eye examinations yielded normal results served as control subjects. Detailed slit-lamp biomicroscopic examinations were performed to assess corneal findings and confirm the presence or absence of the palisades of Vogt. Goblet cell density on the peripheral corneal epithelium and inferior conjunctival epithelium was calculated via impression cytology and was statistically compared between aniridic eyes and control eyes.


RESULTS
All 16 aniridic eyes had superficial corneal opacification and vascularization of either the peripheral or entire cornea. Palisades of Vogt were completely absent all around the limbal area. Goblet cell density on the peripheral cornea and inferior conjunctiva showed a statistically significant increase in the aniridic eyes (226 +/- 169 cells/mm2 and 406 +/- 203 cells/mm2), as compared with the control eyes (O cells/mm2 and 181 +/- 89 cells/mm2) (P = .0005 and P = .0102).


CONCLUSIONS
These findings suggest that, in the aniridic eye, conjunctival epithelium invades the cornea because of corneal epithelial stem cell deficiency.
Nishida
K
K
Department of Ophthalmology, Kyoto Prefectural University of Medicine, Japan.
Kinoshita
S
S
Ohashi
Y
Y
Kuwayama
Y
Y
Yamamoto
S
S
D000293:Adolescent; D000328:Adult; D000368:Aged; D015783:Aniridia / Q000150:complications*; D002452:Cell Count; D003228:Conjunctiva / Q000473:pathology; D003315:Cornea / Q000473:pathology*; D016510:Corneal Neovascularization / Q000150:complications* / Q000473:pathology; D003318:Corneal Opacity / Q000150:complications* / Q000473:pathology; D004848:Epithelium / Q000473:pathology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies; D013234:Stem Cells / Q000473:pathology