Hypoxic-ischemic encephalopathy. Therapeutic approaches against microvascular injury, and role of neutrophils, PAF, and free radicals.
The asphyxiated newborn undergoes progressive brain damage even after resuscitation. This article reviews the microvascular events that contribute to evolving brain injury. The role of neutrophils, platelet-activating factor (PAF), and free radicals is stressed as pivotal mechanisms of injury and opportunities for therapeutic intervention.
Palmer
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Department of Pediatrics, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, USA.
D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001238:Asphyxia Neonatorum / Q000150:complications*; D001921:Brain / Q000098:blood supply* / Q000378:metabolism; D001925:Brain Damage, Chronic / Q000209:etiology / Q000517:prevention & control; D002545:Brain Ischemia / Q000209:etiology* / Q000628:therapy*; D002415:Cats; D002560:Cerebrovascular Circulation; D005609:Free Radicals; D006801:Humans; D002534:Hypoxia, Brain / Q000209:etiology* / Q000628:therapy*; D007231:Infant, Newborn; D008833:Microcirculation; D009504:Neutrophils / Q000502:physiology*; D010972:Platelet Activating Factor / Q000502:physiology*; D051381:Rats; D015427:Reperfusion Injury / Q000209:etiology / Q000517:prevention & control
D000975:Antioxidants; D005609:Free Radicals; D010972:Platelet Activating Factor