[The effect of piyavit on hemostatic processes and fibrinolysis in patients with ischemic heart disease].
The oral use of the drug Piavit (derived from freeze-dried medicinal leeches) in 50 patients with coronary heart disease for 7 days in a daily dose of 600 mg (20 patients) and 1200 mg (30 patients) caused a moderate dose-independent increase in enzymatic, fibrinolysis, non-enzymatic fibrinolysis and antithrombin III activity. In half the patients who had low fibrinolytic levels, the agent stimulated mainly the release of plasminogen activator on administration days of 2 and 7. In other 15 patients the activity of plasminogen activator remained unchanged, but non-enzymatic fibrinolysis enhanced. Piavit prolonged the hypocoagulative effect of heparin and aspirin in the group of patients pretreated with these drugs. There were no clinical manifestations of the disease during 7 days.
Panchenko
V M
VM
Serebriakova
T N
TN
Podorol'skaia
L V
LV
Sorokoletov
S M
SM
Dzhanashiia
P Kh
PKh
D000368:Aged; D000818:Animals; D001685:Biological Factors / Q000008:administration & dosage / Q000494:pharmacology*; D002214:Capsules; D002908:Chronic Disease; D004341:Drug Evaluation; D004347:Drug Interactions; D005260:Female; D005342:Fibrinolysis / Q000187:drug effects*; D005343:Fibrinolytic Agents / Q000008:administration & dosage / Q000494:pharmacology*; D006487:Hemostasis / Q000187:drug effects*; D006801:Humans; D007865:Leeches; D008297:Male; D008875:Middle Aged; D017202:Myocardial Ischemia / Q000097:blood* / Q000188:drug therapy*; D012463:Saliva
D001685:Biological Factors; D002214:Capsules; D005343:Fibrinolytic Agents; C094838:piyavit
Vliianie piiavita na protsessy gemostaza, fibrinoliza u bol'nykh ishemicheskoĭ bolezn'iu serdtsa.