title: A secondary air kerma strength standard for Yb-169 interstitial brachytherapy sources.
abstract: Ytterbium-169 (169Yb) is a promising new intermediate low-energy isotope for interstitial implantation. To date, no air kerma strength (SK) standard for this source exists that can serve as a sound foundation for comparing various dose measurements and theoretical calculations. We have solved this problem by adapting the free air measurement technique of Goetsch et al, originally developed for 192Ir. Using a 100 cm3 spherical ion chamber with NIST traceable external beam calibrations in a free air geometry, we have measured the air kerma strength of six different source batches (two type 6 batches, three type 8 batches, and one experimental high-intensity source). Room scatter corrections, derived from an empirical fit to the data (following Goetsch et al) and/or directly by Monte Carlo simulation, yielded identical results with a reproducibility of 1%. The ratio [SK/Avendor] of measured SK to the vendor's contained activity assay averaged 1.554 cGy cm2 mCi-1 h-1 (0.0420 microGy m2 MBq-1 h-1), in conflict with the expected value of 1.34 (0.0362), derived from Monte Carlo calculations. The measured [SK/Avendor] for the type 8 seeds varies by as much as 10% whereas the SK/dose calibrator reading ratio varies by no more than 0.3%, suggesting that the reproducibility of Avendor is relatively poor. These discrepancies may help explain the variation (as large as 28%) in published dose rate constants for 169Yb.
authors.affiliation: Radiation Oncology Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA.
authors.forename: R K
authors.initials: RK
authors.lastname: Das
authors.forename: V
authors.initials: V
authors.lastname: Mishra
authors.forename: H
authors.initials: H
authors.lastname: Perera
authors.forename: A S
authors.initials: AS
authors.lastname: Meigooni
authors.forename: J F
authors.initials: JF
authors.lastname: Williamson
mesh_terms: D000388:Air; D055592:Biophysical Phenomena; D001703:Biophysics; D001918:Brachytherapy / Q000592:standards*; D006801:Humans; D009010:Monte Carlo Method; D011868:Radioisotopes / Q000008:administration & dosage / Q000592:standards*; D011874:Radiometry / Q000295:instrumentation; D012015:Reference Standards; D012542:Scattering, Radiation; D015018:Ytterbium / Q000008:administration & dosage* / Q000592:standards*
chemical_list: D011868:Radioisotopes; D015018:Ytterbium