title: Polyphenols from Eriosema tuberosum.
abstract: A dichloromethane extract of the roots of Eriosema tuberosum exhibited antifungal activity against Cladosporium cucumerinum and Candida albicans using TLC bioautography. Bioassay-directed fractionation led to the isolation of four new compounds, eriosemaones A-D, together with a known compound, flemichin-D, as the active constituents. Three inactive polyphenols were also isolated after methylation, together with one new chromone, eriosematin. Structures were determined by spectroscopic analysis and from chemical evidence.
authors.affiliation: Institut de Pharmacognosie et Phytochimie, Université de Lausanne, Switzerland.
authors.forename: W G
authors.initials: WG
authors.lastname: Ma
authors.forename: N
authors.initials: N
authors.lastname: Fuzzati
authors.forename: Q S
authors.initials: QS
authors.lastname: Li
authors.forename: C R
authors.initials: CR
authors.lastname: Yang
authors.forename: H
authors.initials: H
authors.lastname: Stoeckli-Evans
authors.forename: K
authors.initials: K
authors.lastname: Hostettmann
mesh_terms: D000935:Antifungal Agents / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002176:Candida albicans / Q000187:drug effects*; D002867:Chromones / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D002963:Cladosporium / Q000187:drug effects*; D008826:Microbial Sensitivity Tests; D010636:Phenols / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D010936:Plant Extracts / Q000494:pharmacology; D010946:Plants, Medicinal; D013329:Structure-Activity Relationship
chemical_list: D000935:Antifungal Agents; D002867:Chromones; D010636:Phenols; D010936:Plant Extracts