Toxicity of fumonisin B1 administered intraperitoneally to male Sprague-Dawley rats.
The toxicity of purified fumonisin B1 (FB1) administered ip was examined in male Sprague-Dawley rats. FB1 was injected at 7.5 or 10 mg/kg body weight/day for 4 consecutive days. This resulted in significant reductions in body weight, food consumption and faeces production. Polyuria without a compensatory increase in water consumption was observed in treated rats. Erythrocytosis, elevated haematocrits and haemoglobin levels were attributed to dehydration. Nephrotoxicity in treated rats was evident by clinical changes including elevated blood urea nitrogen and by subtle changes in kidney morphology. Histopathology and serum biochemistry also indicated that the liver was an important target organ in FB1-treated rats. A small increase in liver glutathione concentration was also evident in rats receiving 10 mg FB1/kg body weight. Effects on the immune system included reduced thymus weight, disseminated thymic necrosis and consistently elevated serum immunoglobulin M levels. Circulating phagocytic cell numbers were elevated in treated rats, probably owning to tissue damage associated with ip dosing. The liver and kidneys appear to be target organs of FB1 in Sprague-Dawley rats.
Bondy
G
G
Toxicology Research Division (2204D2), Health Protection Branch, Ottawa, Ontario, Canada.
Suzuki
C
C
Barker
M
M
Armstrong
C
C
Fernie
S
S
Hierlihy
L
L
Rowsell
P
P
Mueller
R
R
D000818:Animals; D001835:Body Weight / Q000187:drug effects; D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology; D002274:Carcinogens, Environmental / Q000008:administration & dosage / Q000633:toxicity*; D002149:Energy Intake / Q000187:drug effects; D005243:Feces; D037341:Fumonisins; D005978:Glutathione / Q000378:metabolism; D006400:Hematocrit; D007136:Immunoglobulins / Q000187:drug effects; D007274:Injections, Intraperitoneal; D007668:Kidney / Q000187:drug effects* / Q000473:pathology; D008099:Liver / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009183:Mycotoxins / Q000008:administration & dosage / Q000633:toxicity*; D009929:Organ Size / Q000187:drug effects; D051381:Rats; D017207:Rats, Sprague-Dawley
D002274:Carcinogens, Environmental; D037341:Fumonisins; D007136:Immunoglobulins; D009183:Mycotoxins; C056933:fumonisin B1; D005978:Glutathione