Pulmonary response to cadmium and nickel coated fly ash.
Pulmonary reaction to fly ash coated with cadmium (Cd) or nickel (Ni) and to native fly ash was studied in rats after intratracheal inoculation of dust suspensions. The histopathological alterations and changes in biochemical and cellular constituents of the bronchoalveolar lavage were correlated with the metal content in lungs and kidneys. More Ni was adsorbed than Cd on fly ash particulates. Metal-coated fly ash was more toxic than uncoated fly ash. Cd-coated fly ash produced significantly more histopathological and biochemical changes than Ni-coated fly ash. A high concentration of Cd was detected in the kidneys of rats exposed to Cd-coated fly ash.
Bajpai
R
R
Industrial Toxicology Research Centre, Lucknow, India.
Waseem
M
M
Kaw
J L
JL
D000327:Adsorption; D000818:Animals; D001992:Bronchoalveolar Lavage Fluid / Q000166:cytology; D002104:Cadmium / Q000493:pharmacokinetics / Q000633:toxicity*; D002244:Carbon / Q000009:adverse effects* / Q000493:pharmacokinetics; D003031:Coal / Q000009:adverse effects*; D060729:Coal Ash; D007220:Industrial Waste / Q000009:adverse effects*; D007668:Kidney / Q000187:drug effects / Q000378:metabolism; D008168:Lung / Q000187:drug effects* / Q000378:metabolism / Q000473:pathology; D008297:Male; D009532:Nickel / Q000493:pharmacokinetics / Q000633:toxicity*; D052638:Particulate Matter; D051381:Rats; D017208:Rats, Wistar
D003031:Coal; D060729:Coal Ash; D007220:Industrial Waste; D052638:Particulate Matter; D002104:Cadmium; D002244:Carbon; D009532:Nickel