title: Effects of pentoxifylline on human sperm parameters in vitro.
abstract: OBJECTIVE
  Pentoxifylline was tested in three raising concentrations (0.7 mM/l, 1.5 mM/l, 3.6 mM/l) on human sperm cells in vitro.
  
  
  METHODS
  On 143 samples, we examined drug effect on motile sperm concentration, grade of their motility, acrosome reaction and membrane status.
  
  
  RESULTS
  Obtained results show improvement in motile sperm concentration, as well as in the grade of progression in the majority of samples.
  
  
  CONCLUSIONS
  Spermatozoa membranes as well as occurrence of the acrosomal reaction were not affected by pentoxifylline.
authors.affiliation: Institute for the Application of Nuclear Energy--INEP, Belgrade, Yugoslavia.
authors.forename: I
authors.initials: I
authors.lastname: Mladenovic
authors.forename: S
authors.initials: S
authors.lastname: Micic
authors.forename: R M
authors.initials: RM
authors.lastname: Pearson
authors.forename: O
authors.initials: O
authors.lastname: Genbacev
authors.forename: N
authors.initials: N
authors.lastname: Papic
mesh_terms: D000177:Acrosome / Q000187:drug effects; D002462:Cell Membrane / Q000187:drug effects; D006801:Humans; D008297:Male; D010431:Pentoxifylline / Q000494:pharmacology*; D013081:Sperm Motility / Q000187:drug effects*; D013094:Spermatozoa / Q000187:drug effects* / Q000502:physiology / Q000648:ultrastructure
chemical_list: D010431:Pentoxifylline