title: Contemporary management of atrial fibrillation.
abstract: The incidence of atrial fibrillation approximately doubled for every 10-year increment in age in the Framingham Heart Study cohort; thus physicians will be faced with an increasing patient population with atrial fibrillation. Hypertension is observed to be the most common associated risk factor in both sexes. The management of patients with atrial fibrillation is evolving as a result of a number of published studies. Calcium channel blockers and beta-blockers are emerging as the preferred choices for rate control rather than digoxin. Low-dose anticoagulation therapy has shown beneficial effects not only in primary prevention, but also for secondary prevention of thromboembolism. Thus, patients who cannot be successfully cardioverted should be anticoagulated if there are no contraindications (Table 3) and if they do not fall into the low-risk group--defined as patients under the age of 65 without risk factors (hypertension, diabetes, previous stroke). Patients not eligible for anticoagulation should be on aspirin therapy. Patients with lone atrial fibrillation are not at higher risk for thromboembolism than the general population; therefore, they can be managed without anticoagulation or antiplatelet therapy. Antiarrhythmic treatment should be approached cautiously; amiodarone in low doses is the most effective and safe treatment, but this remains controversial.
authors.affiliation: Department of Medicine, Norwalk Hospital, Connecticut.
authors.forename: Z A
authors.initials: ZA
authors.lastname: Ukani
authors.forename: M D
authors.initials: MD
authors.lastname: Ezekowitz
mesh_terms: D000889:Anti-Arrhythmia Agents / Q000627:therapeutic use; D001281:Atrial Fibrillation / Q000453:epidemiology / Q000209:etiology / Q000628:therapy*; D017115:Catheter Ablation; D004554:Electric Countershock; D004617:Embolism / Q000188:drug therapy / Q000209:etiology; D005260:Female; D006801:Humans; D008297:Male; D018579:Patient Selection; D012307:Risk Factors
chemical_list: D000889:Anti-Arrhythmia Agents