Bone marrow histiocytic proliferation in association with colony-stimulating factor therapy.
A 6-year-old white male had a myelodysplastic syndrome (refractory anemia with excess blasts in transformation) and was treated with high dose chemotherapy. A combined esterase stain of the marrow blasts showed granulocytic differentiation. Subsequently, persistent pancytopenia with a severely hypocellular bone marrow developed, which was treated with a combination of granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor. Sixteen days after the initiation of therapy, histologic examination of the bone marrow revealed a marked proliferation of histiocytes. To the best of the authors' knowledge, this is the first report of histiocytic proliferation in the bone marrow after colony-stimulating factor therapy.
Wilson
P A
PA
Department of Pathology, University of North Carolina, Chapel Hill 27599.
Ayscue
L H
LH
Jones
G R
GR
Bentley
S A
SA
D001853:Bone Marrow / Q000187:drug effects / Q000473:pathology*; D002455:Cell Division / Q000187:drug effects; D002648:Child; D016179:Granulocyte Colony-Stimulating Factor / Q000009:adverse effects / Q000627:therapeutic use; D016178:Granulocyte-Macrophage Colony-Stimulating Factor / Q000009:adverse effects* / Q000627:therapeutic use; D006644:Histiocytes / Q000187:drug effects / Q000473:pathology*; D006801:Humans; D008297:Male; D009190:Myelodysplastic Syndromes / Q000628:therapy*; D016188:Receptors, Granulocyte Colony-Stimulating Factor
D016188:Receptors, Granulocyte Colony-Stimulating Factor; D016179:Granulocyte Colony-Stimulating Factor; D016178:Granulocyte-Macrophage Colony-Stimulating Factor