title: Adult onset familial hemiplegic migraine.
abstract: Familial hemiplegic migraine and its associated signs and symptoms have previously been well described. The condition demonstrates autosomal dominant inheritance and has been recently assigned to a locus on chromosome 19. Previous reports of familial hemiplegic migraine have indicated that expression always occurs early in life. We describe a patient who presented with multiple episodes of reversible hemiplegia followed by headache at the age of 75. Seven other family members were found to have been affected in a similar manner. We believe this case represents a unique description of familial hemiplegic migraine presenting in later life.
authors.affiliation: Cooper Hospital, University Medical Center, UMDNJ, Robert Wood Johnson Medical School, Camden 08103, USA.
authors.forename: V
authors.initials: V
authors.lastname: Rajput
authors.forename: E D
authors.initials: ED
authors.lastname: Kramer
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006429:Hemiplegia / Q000209:etiology / Q000235:genetics*; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000150:complications / Q000235:genetics*; D010375:Pedigree