title: Intracellular pharmacology and biochemistry of methotrexate and 6-mercaptopurine in childhood acute lymphoblastic leukemia.
authors.affiliation: Center for Pediatric Oncology, University Hospital, Nijmegen, The Netherlands.
authors.forename: C W
authors.initials: CW
authors.lastname: Keuzenkamp-Jansen
authors.forename: J P
authors.initials: JP
authors.lastname: Bökkerink
authors.forename: J M
authors.initials: JM
authors.lastname: Trijbels
authors.forename: M A
authors.initials: MA
authors.lastname: vd Heijden
authors.forename: R A
authors.initials: RA
authors.lastname: De Abreu
mesh_terms: D000284:Administration, Oral; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000378:metabolism / Q000627:therapeutic use*; D002648:Child; D004912:Erythrocytes / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D007262:Infusions, Intravenous; D002955:Leucovorin / Q000008:administration & dosage; D007963:Leukocytes, Mononuclear / Q000187:drug effects / Q000378:metabolism; D015122:Mercaptopurine / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D008727:Methotrexate / Q000008:administration & dosage / Q000378:metabolism* / Q000494:pharmacology; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000097:blood* / Q000188:drug therapy*; D011687:Purines / Q000097:blood; D011743:Pyrimidines / Q000097:blood
chemical_list: D011687:Purines; D011743:Pyrimidines; D015122:Mercaptopurine; D002955:Leucovorin; D008727:Methotrexate