[Study on shelf-life prediction of drugs under indoor natural light irradiation].
The photodegradation of drugs under natural light and various lamp light irradiation was studied and the shelf-life of drugs under indoor natural light irradiation was predicted with hydroxyprogesterone caproate injection as an example. The equivalent influences of different light sources on the photostability of the above drug were obtained. Therefore, the natural light photostability and the shelf-life of drugs under indoor natural light irradiation can be studied with lamp light exposure experiment. The photodegradation of hydroxyprogesterone caproate injection obeys zero order kinetics: C = C0-kEt, and its shelf-life under indoor natural light irradiation is about 1.9 years.
Zhan
X C
XC
School of Pharmacy, West China University of Medical Sciences, Chengdu.
Mi
G H
GH
Yin
G K
GK
Ma
B Z
BZ
Luo
G W
GW
D000077713:17 alpha-Hydroxyprogesterone Caproate; D004355:Drug Stability; D004356:Drug Storage; D006908:Hydroxyprogesterones / Q000737:chemistry*; D008027:Light
D006908:Hydroxyprogesterones; D000077713:17 alpha-Hydroxyprogesterone Caproate