[The role of macrophage suppressor activity in the mechanism of metastasis after tumor resection].
The rates of spontaneous metastasis to the lung (SML) and lymph nodes, cytotoxic and antimetastatic activity (AA) of macrophages in the course of and after resection of transplantable mammary adenocarcinoma MMTI as well as cloned tumor MMTv4 were studied in C3Hf mice. Murine macrophages showed AA in adoptive test in the course of MMTv4 growth and specific cytotoxic activity in tests in vitro. Macrophages from bearers of MMTv4 revealed non-specific cytotoxicity only. After tumor resection, a sharp increase in SML and metastasizing into lymph nodes was matched by a lack of AA and cytotoxic activity on the part of macrophages in mice operated on. In tumor cell recipients, they were found to stimulate metastasis formation. Only 60% of operated mice survived and macrophages obtained from them did not reveal any metastasis-stimulating activity. This activity was further curbed due to injections of indomethacin--an inhibitor of prostaglandin E2 synthesis--or as a result of indomethacin pretreatment of macrophages in vitro. The above data implicate suppressor activity in the explosion of metastatic formation observed after tumor resection. The role of macrophage suppressors and that of of prostaglandin E2 in postsurgical stimulation of metastasis spreading are discussed.
Iunker
V M
VM
Smirnova
N P
NP
Ustinov
A S
AS
D000230:Adenocarcinoma / Q000503:physiopathology* / Q000556:secondary / Q000601:surgery; D000818:Animals; D015232:Dinoprostone / Q000502:physiology; D007213:Indomethacin / Q000494:pharmacology; D008175:Lung Neoplasms / Q000503:physiopathology* / Q000556:secondary; D008264:Macrophages / Q000187:drug effects / Q000502:physiology*; D008297:Male; D008325:Mammary Neoplasms, Experimental / Q000503:physiopathology* / Q000601:surgery; D051379:Mice; D008809:Mice, Inbred C3H
D015232:Dinoprostone; D007213:Indomethacin
Rol' makrofagov s supressornoĭ aktivnost'iu v mekhanizme stimuliatsii metastazirovaniia posle rezektsii opukholi.