title: Cloning and sequencing of a cDNA encoding the canine HSP27 protein.
abstract: The nucleotide (nt) sequence encoding a 27-kDa heat-shock protein (HSP27) was determined from cDNAs cloned from a canine smooth muscle library. The primary structure deduced from the nt sequence reveals a 209-amino-acid protein having 86-89% identity with human, mouse, rat and hamster small HSP. Similar to human HSP27, the canine protein contains three Ser residues that are potential MAPKAP kinase II substrates.
authors.affiliation: Department of Pharmacology, University of Nevada School of Medicine, Reno, USA.
authors.forename: J K
authors.initials: JK
authors.lastname: Larsen
authors.forename: W T
authors.initials: WT
authors.lastname: Gerthoffer
authors.forename: E
authors.initials: E
authors.lastname: Hickey
authors.forename: L A
authors.initials: LA
authors.lastname: Weber
mesh_terms: D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D006224:Cricetinae; D018076:DNA, Complementary / Q000235:genetics*; D004285:Dogs; D006360:Heat-Shock Proteins / Q000737:chemistry / Q000235:genetics*; D006801:Humans; D047908:Intracellular Signaling Peptides and Proteins; D051379:Mice; D008969:Molecular Sequence Data; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism; D051381:Rats; D017386:Sequence Homology, Amino Acid; D012694:Serine / Q000737:chemistry; D013045:Species Specificity; D013379:Substrate Specificity; D000099190:MAP-Kinase-Activated Kinase 2
chemical_list: D018076:DNA, Complementary; D006360:Heat-Shock Proteins; D047908:Intracellular Signaling Peptides and Proteins; D017346:Protein Serine-Threonine Kinases; D012694:Serine; D000099190:MAP-Kinase-Activated Kinase 2