Lipid microspheres for drug delivery from the pharmaceutical viewpoint.
Lipid microsphere (LM) preparations of corticosteroid, nonsteroid, anti-inflammatory drugs and prostaglandins all showed more potent activity than free drugs. The LM, with a diameter of 0.2 microns, were drug carriers prepared from soybean oil and lecithin, with the drug being incorporated within the LM. This study suggests that the LM is a very promising carrier in a drug delivery system. Future trends in this field are outlined, followed by a discussion of physicochemical properties in the evaluation of novel emulsion delivery systems.
Yamaguchi
T
T
Department of Pharmaceutics, Taisho Pharmaceutical Co., Ltd., Saitama, Japan.
Mizushima
Y
Y
D000327:Adsorption; D000527:Alprostadil / Q000008:administration & dosage* / Q000737:chemistry / Q000494:pharmacology; D001682:Biological Availability; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology; D016503:Drug Delivery Systems; D004655:Emulsions; D005480:Flurbiprofen / Q000008:administration & dosage / Q000494:pharmacology; D006801:Humans; D008055:Lipids / Q000737:chemistry*; D008863:Microspheres; D010316:Particle Size; D010713:Phosphatidylcholines / Q000737:chemistry / Q000378:metabolism; D013024:Soybean Oil / Q000737:chemistry / Q000378:metabolism
D004655:Emulsions; D008055:Lipids; D010713:Phosphatidylcholines; D005480:Flurbiprofen; D003907:Dexamethasone; D013024:Soybean Oil; D000527:Alprostadil