[The study of relationship between c-erbB2 expression and cytoimmunology in ovarian carcinoma and its antisense regulation].
The relationship between c-erbB2 expression and cytoimmunology in ovarian carcinoma cell lines was studied; the synthesized and modified c-erbB2 antisense oligodeoxynucleotide was tested for its ability to reduce over-expression of c-erbB2. The results showed that over-expression of c-erbB2 in ovarian carcinoma could induce resistance to tumor necrosis factor (TNF) and lymphokine activated killer (LAK) cells but had no effect on H2O2; c-erbB2 antisense oligodeoxynucleotide could specifically reduce the over-expression of c-erbB2 and increase the sensitivity of ovarian cancer targets to lysis by TNF and LAK cells.
Jin
Z
Z
Obstet and Gynecol Hospital, Shanghai Medical University.
Zhang
X
X
Feng
Y
Y
D001483:Base Sequence; D005260:Female; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects; D018734:Genes, erbB-2; D006801:Humans; D015979:Killer Cells, Lymphokine-Activated / Q000276:immunology; D008969:Molecular Sequence Data; D016376:Oligonucleotides, Antisense / Q000494:pharmacology; D010051:Ovarian Neoplasms / Q000235:genetics* / Q000473:pathology; D014407:Tumor Cells, Cultured; D014409:Tumor Necrosis Factor-alpha / Q000494:pharmacology
D016376:Oligonucleotides, Antisense; D014409:Tumor Necrosis Factor-alpha