title: Clinical efficacy of diclofenac sodium on postsurgical inflammation after intraocular lens implantation.
abstract: We investigated the anti-inflammatory effects of 0.1% diclofenac sodium on anterior inflammation after cataract surgery. Fibrin precipitation after surgery in patients without systemic or ocular disease was markedly less when diclofenac sodium ophthalmic solution was used in combination with topical corticosteroids. There was also a reduction in fibrin precipitation in other patients, especially in those with diabetes mellitus, primary angle-closure glaucoma, and exfoliation syndrome. In conclusion, diclofenac sodium was shown to be clinically useful as a topical preparation to suppress inflammation after cataract surgery.
authors.affiliation: Department of Ophthalmology, Oita Medical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Matsuo
authors.forename: H
authors.initials: H
authors.lastname: Hojou
authors.forename: M
authors.initials: M
authors.lastname: Honbou
authors.forename: N
authors.initials: N
authors.lastname: Miyata
mesh_terms: D000287:Administration, Topical; D000368:Aged; D000369:Aged, 80 and over; D000869:Anterior Eye Segment / Q000187:drug effects; D001623:Betamethasone / Q000627:therapeutic use; D002387:Cataract Extraction / Q000009:adverse effects*; D004008:Diclofenac / Q000008:administration & dosage / Q000627:therapeutic use*; D004359:Drug Therapy, Combination; D009877:Endophthalmitis / Q000209:etiology / Q000517:prevention & control*; D005260:Female; D005337:Fibrin / Q000378:metabolism; D005342:Fibrinolysis / Q000187:drug effects; D006801:Humans; D007910:Lenses, Intraocular / Q000009:adverse effects*; D008297:Male; D008875:Middle Aged; D009883:Ophthalmic Solutions; D011183:Postoperative Complications / Q000209:etiology / Q000517:prevention & control*; D012189:Retrospective Studies
chemical_list: D009883:Ophthalmic Solutions; D004008:Diclofenac; D005337:Fibrin; D001623:Betamethasone