[Synthesis and properties of membrane-addressed antioxidants based on phosphorylated pyrocatechols].
Amphiphilic membrane-addressed antioxidants differing in their hydrophobic-hydrophilic balance, 3,5-di-tert-butyl-2-hydroxyphenyl phosphate, (3,5-di-tert-butyl-2-hydroxyphenyl)hexadecyl phosphate, and (3,5-di-tert-butyl-2-hydroxyphenyl)-5-cholesten-3 beta-yl phosphate, were synthesized starting from 3,5-di-tert-butyl-o-quinone. Even at 10(-8) M concentration, 3,5-di-tert-butyl-2-hydroxyphenyl phosphate and (3,5-di-tert-butyl-2-hydroxyphenyl)hexadecyl phosphate inhibit formation of malonic aldehyde during peroxidation of lipids from rat brain homogenate initiated with a Fe(2+)-ascorbate system. At 10(-4) M and higher concentrations of antioxidants in the brain homogenate, the formation of malonic aldehyde is inhibited more efficiently than with tocopherol at the same concentrations.
Akhrem
A A
AA
Dolgopalets
V I
VI
Kisel'
M A
MA
Mezen
N I
NI
Timoshchuk
V A
VA
Fedulov
A S
AS
Shadyro
O I
OI
D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002396:Catechols / Q000737:chemistry* / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D015227:Lipid Peroxidation; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000378:metabolism; D010766:Phosphorylation; D051381:Rats
D000975:Antioxidants; D002396:Catechols; D009943:Organophosphorus Compounds; C034221:catechol
Sintez i svoĭstva membranoadresovannykh antioksidantov na osnove fosforilirovannykh pirokatekhinov.