Polyclonal Epstein-Barr virus-associated lymphoproliferative disorder following autografting for chronic myeloid leukemia.
Epstein-Barr-associated lymphoproliferative disorders have been described as complications of immunodeficiency states including allogeneic BMT. There is, however, only one report in the English language literature of such a disorder after autografting. We report a 56-year-old man undergoing autologous BMT for CML in whom a rapidly progressive lymphoproliferative disorder showing the histology of typical post-transplant lymphoproliferative disorder with latent EBV presence developed at approximately 30 days after BMT. Therapy with corticosteroids, acyclovir and alpha-interferon was instituted and led to prompt resolution of symptoms and signs. There was no evidence of lymphoproliferative disease at 7 months after BMT. It is concluded that EBV-associated lymphoproliferative disorders may be a complication, albeit a rare one, of intensive therapy with autologous stem cell support.
Shepherd
J D
JD
Leukemia/Bone Marrow Transplantation Program of British Columbia, B.C. Cancer Agency, Vancouver General Hospital, Canada.
Gascoyne
R D
RD
Barnett
M J
MJ
Coghlan
J D
JD
Phillips
G L
GL
D016026:Bone Marrow Transplantation; D004854:Herpesvirus 4, Human / Q000302:isolation & purification*; D006801:Humans; D015464:Leukemia, Myelogenous, Chronic, BCR-ABL Positive / Q000150:complications / Q000628:therapy*; D008232:Lymphoproliferative Disorders / Q000175:diagnosis / Q000821:virology*; D008297:Male; D008875:Middle Aged; D014182:Transplantation, Autologous