Collagen gene expression in radiation interstitial pneumonitis.
By using type I and type III collagen cDNA probe and cDNA-mRNA in situ hybridization, we observed the changes of rat lung alpha 1(I) and alpha 1(III) collagen gene expression in radiation interstitial pneumonitis. The results showed that the expressed cell of type I and type III collagen were scattered within the fibroblasts in the thickened interalveolar walls. The type I and type III collagen mRNA content in irradiated animals were higher than those in the controls at 0.5, 1, 2, 3, 6, and 12 months.
Bai
Y H
YH
Department of Experimental Pathology, Institute of Radiation Medicine, Beijing, China.
Wang
D W
DW
Cui
C B
CB
Ci
Y P
YP
Cui
X M
XM
Xiong
C Q
CQ
Zhang
Z S
ZS
Liu
B C
BC
D000818:Animals; D003094:Collagen / Q000096:biosynthesis / Q000235:genetics*; D015870:Gene Expression; D017403:In Situ Hybridization; D008297:Male; D012333:RNA, Messenger / Q000235:genetics; D017564:Radiation Pneumonitis / Q000235:genetics*; D051381:Rats; D017208:Rats, Wistar
D012333:RNA, Messenger; D003094:Collagen