title: Liquid/air partition coefficients of the trimethylbenzenes.
abstract: Liquid/air partition coefficients (lambda) of the three isomers of trimethylbenzene (1,2,3-,1,2,4-, and 1,3,5-TMB) were determined in vitro using automated head space gas chromatography. The liquids used were water (physiological saline), fresh human blood, and olive oil. The lambda water/air were 1.23 (95% confidence interval 1.11-1.35) for 1,3,5-TMB, 1.61 (1.47-1.75) for 1,2,4-TMB, and 2.73 (2.54-2.92) for 1,2,3-TMB. Corresponding lambda blood/air were 43.0 (40.8-45.2), 59.1 (56.9-61.3), and 66.5 (63.7-69.3). As expected, the TMBs have a high affinity for olive oil, the lambda oil/air being 9,880 (9,620-10,140), 10,200 (9,900-10,400), and 10,900 (10,500-11,300), respectively. It is notable that all partition coefficients increase in the order 1,3,5-TMB < 1,2,4-TMB < 1,2,3-TMB.
authors.affiliation: Department of Toxicology National Institute of Occupational Health Solna, Sweden.
authors.forename: J
authors.initials: J
authors.lastname: Järnberg
authors.forename: G
authors.initials: G
authors.lastname: Johanson
mesh_terms: D000388:Air / Q000032:analysis*; D001555:Benzene Derivatives / Q000032:analysis* / Q000493:pharmacokinetics; D001774:Blood Chemical Analysis; D006801:Humans; D000069463:Olive Oil; D010938:Plant Oils / Q000737:chemistry; D012995:Solubility; D014867:Water / Q000737:chemistry*
chemical_list: D001555:Benzene Derivatives; D000069463:Olive Oil; D010938:Plant Oils; D014867:Water; C010313:pseudocumene