Caseating cutaneous granulomas in a child with common variable immunodeficiency.
Cutaneous, noninfectious, granulomatous lesions have been reported occasionally in different types of immunodeficiencies, including common variable immunodeficiency (CVD). We present a child with CVID and cutaneous granulomas with a strikingly prominent caseating necrosis. We think that such granulomatous lesions constitute a distinctive manifestation of immunodeficiency, and may reflect a altered immune response. Corticosteroids have been of benefit to our patient, as well as in similar cases.
Torrelo
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Department of Pediatric Dermatology, Hospital del Niño Jesús, Madrid, Spain.
Mediero
I G
IG
Zambrano
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D002648:Child; D017074:Common Variable Immunodeficiency / Q000150:complications* / Q000473:pathology; D005148:Facial Dermatoses / Q000150:complications / Q000473:pathology; D006099:Granuloma / Q000150:complications* / Q000473:pathology; D006644:Histiocytes / Q000473:pathology; D006801:Humans; D007868:Leg Dermatoses / Q000150:complications / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology; D008297:Male; D009336:Necrosis; D011241:Prednisone / Q000627:therapeutic use; D012871:Skin Diseases / Q000150:complications* / Q000473:pathology
D011241:Prednisone