title: Effect of a recent injection of purified protein derivative on diagnostic tests for tuberculosis in cattle infected with Mycobacterium bovis.
abstract: The intradermal injection of avian and bovine purified protein derivative into 15 Mycobacterium bovis-infected cattle reduced the capacity of a second single intradermal comparative tuberculin test carried out seven days later to predict accurately the animals' infection status (P < 0.001). In vitro lymphyocyte blastogenesis was also reduced (P < 0.05) but the in vitro production of interferon-gamma was unaffected.
authors.affiliation: Faculty of Veterinary Medicine, University College Dublin, Ballsbridge, Ireland.
authors.forename: M L
authors.initials: ML
authors.lastname: Doherty
authors.forename: M L
authors.initials: ML
authors.lastname: Monaghan
authors.forename: H F
authors.initials: HF
authors.lastname: Bassett
authors.forename: P J
authors.initials: PJ
authors.lastname: Quinn
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology; D007271:Injections, Intradermal; D007371:Interferon-gamma / Q000032:analysis; D008213:Lymphocyte Activation; D008214:Lymphocytes / Q000276:immunology; D008297:Male; D009163:Mycobacterium bovis / Q000276:immunology; D014373:Tuberculin / Q000276:immunology*; D014374:Tuberculin Test / Q000662:veterinary*; D014380:Tuberculosis, Bovine / Q000175:diagnosis* / Q000276:immunology / Q000382:microbiology
chemical_list: D014373:Tuberculin; D007371:Interferon-gamma