Translational control of gene expression.
Translational regulation of mRNA is an important step in the control of gene expression. In a general way, the efficiency of the translational apparatus can be influenced either positively or negatively by changing the level or the activity of rate-limiting protein factors taking part in the process of translation. But translational control can also be very specific, affecting only a single mRNA or class of mRNA molecules. In most of these cases regulation takes place at the level of initiation of translation, which is often attributable to structural peculiarities of the mRNA in question, especially of the 5'-untranslated region or leader. This review summarizes the mechanisms which lie at the root of translational control. A better understanding of these mechanisms will eventually provide us with new drugs and antisense oligonucleotide technology, aimed at influencing the level of expression of single proteins. These developments are of interest to basic researchers and clinicians alike, because they may profoundly change the ways in which we treat, e.g. viral infections and malignancies in the future.
Jansen
M
M
Department of Pediatrics, Utrecht University, The Netherlands.
de Moor
C H
CH
Sussenbach
J S
JS
van den Brande
J L
JL
D000818:Animals; D005815:Genetic Code; D006801:Humans; D011061:Poly A / Q000235:genetics; D014176:Protein Biosynthesis; D021382:Protein Sorting Signals / Q000235:genetics; D012323:RNA Processing, Post-Transcriptional
D021382:Protein Sorting Signals; D011061:Poly A