A new mechanism of toxicity of 2-chlorodeoxyadenosine (2CdA).
Fabianowska-Majewska
K
K
Department of General Chemistry, Medical University of Lódź, Poland.
Wasiak
T J
TJ
Warzocha
K
K
Marlewski
M
M
Fairbanks
L
L
Smoleński
R T
RT
Duley
J
J
Simmonds
A
A
D000225:Adenine / Q000097:blood; D000243:Adenosine Deaminase / Q000097:blood*; D058892:Adenosine Deaminase Inhibitors; D043383:Adenosylhomocysteinase; D017338:Cladribine / Q000633:toxicity*; D004912:Erythrocytes / Q000187:drug effects / Q000201:enzymology; D006801:Humans; D006867:Hydrolases / Q000378:metabolism*; D007700:Kinetics; D008099:Liver / Q000201:enzymology; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors / Q000378:metabolism*; D013379:Substrate Specificity
D058892:Adenosine Deaminase Inhibitors; D017338:Cladribine; D011683:Purine-Nucleoside Phosphorylase; C021784:5'-methylthioadenosine phosphorylase; D006867:Hydrolases; D043383:Adenosylhomocysteinase; D000243:Adenosine Deaminase; D000225:Adenine