title: [Cholecystokinin in regulation of gastric secretion in healthy probands and duodenal ulcer patients].
abstract: Unlike the stimulation of gastric acid secretion, which clearly involves the release of gastrin, the mechanisms of inhibition of this secretory process are poorly defined although recent studies in animals with the use of highly selective cholecystokinin (CCK) antagonists indicate that CCK may play a crucial role in this inhibition. Duodenal ulcer patients (DU) differ from healthy controls by higher total acid secretory rates and diminished inhibition of acid secretion. Several possible pathomechanisms of the abnormal gastric secretory function in DU patients were previously proposed. The deficiency of CCK-induced gastric inhibition in DU patients together with the somatostatin hypothesis appear to be attractive, particularly so the suggestion that a deficiency of somatostatin activity exists in DU patients.
authors.affiliation: Medizinsche Klinik und Poliklinik B, Westfälischen Wilhelms-Universität Münster.
authors.forename: J W
authors.initials: JW
authors.lastname: Konturek
authors.forename: W
authors.initials: W
authors.lastname: Domschke
mesh_terms: D000818:Animals; D002766:Cholecystokinin / Q000502:physiology*; D004381:Duodenal Ulcer / Q000503:physiopathology*; D005744:Gastric Acid / Q000378:metabolism*; D005755:Gastrins / Q000097:blood; D005756:Gastritis / Q000503:physiopathology; D016481:Helicobacter Infections / Q000503:physiopathology; D006801:Humans; D012016:Reference Values; D013004:Somatostatin / Q000502:physiology
chemical_list: D005755:Gastrins; D013004:Somatostatin; D002766:Cholecystokinin
vernacular_title: Cholezystokinin (CCK) in der Regulation der Magensekretion bei Gesunden und Ulcus-duodeni-Patienten.