Management of hypoxic-ischaemic encephalopathy.
Despite many innovations in the management of hypoxic-ischaemic brain injury over the past 20 years, none has been proven to improve the outcome in patients. "Neuroresuscitation" with its emphasis on monitoring and control of intracranial pressure has not increased the number of neurologically intact survivors. New insights into the pathogenesis of hypoxic-ischaemic encephalopathy, particularly the role of calcium ions, excitatory amino acids and free-oxygen radicals, have led to potential treatment modalities which are now under experimental study but cannot as yet be recommended as standard therapy. At present, the cornerstone of management of hypoxic-ischaemic encephalopathy is still supportive care and careful maintenance of systemic homeostasis.
Lee
W L
WL
Department of Neurology, Tan Tock Seng Hospital, Singapore.
D001929:Brain Edema / Q000517:prevention & control; D002545:Brain Ischemia / Q000628:therapy*; D002118:Calcium / Q000502:physiology; D018846:Excitatory Amino Acids / Q000502:physiology; D005609:Free Radicals; D006801:Humans; D002534:Hypoxia, Brain / Q000628:therapy*
D018846:Excitatory Amino Acids; D005609:Free Radicals; D002118:Calcium