[Immunohistochemical study of epidermal growth factor in liver of mice infected with schistosoma japonicum].
In this immunohistochemical study we examined the expression and localization of the epidermal growth factor in liver of mice infected with schistosoma japonicum during regulatory phase of immunology and early phase of hepatic fibrosis. EGF immunostaining is localized along sinusoids and within cytoplasm of centrilobular area and around ova granuloma at 6,8 weeks of infection. Proliferation of Ito cells and collagen deposition in Disse space were found by electron microscope. The data led us to conclude that the ova depositing in liver could excite the release of EGF and cytokines, then promote proliferation of Ito cells and overgrowth of extracellular matrix (ECM) under the endothelium, resulting in hepatic fibrosis.
Yang
Z
Z
Tongji Hospital, Tongji Medical University, Wuhan.
Wang
G
G
Cai
H
H
D000818:Animals; D004815:Epidermal Growth Factor / Q000378:metabolism*; D005109:Extracellular Matrix / Q000378:metabolism; D007150:Immunohistochemistry; D008099:Liver / Q000378:metabolism*; D008106:Liver Cirrhosis, Experimental / Q000378:metabolism; D008297:Male; D051379:Mice; D012554:Schistosomiasis japonica / Q000378:metabolism*
D004815:Epidermal Growth Factor