title: Serial changes in plasma levels of pancreatic elastase 1 after pancreatic surgeries.
abstract: The alterations of the plasma level of elastase 1 (Ela) were investigated in 15 patients undergoing total pancreatectomy (TP), 18 patients undergoing pancreatoduodenectomy (PD), 8 patients undergoing distal pancreatectomy (DP) and 10 patients undergoing gastrectomy for gastric cancer (GR). The Ela level decreased rapidly below the normal level after TP. The plasma half-life of Ela was 4.6 +/- 1.2 h (Mean +/- SEM). The Ela levels after PD were abnormally elevated until the 7th postoperative day. The Ela levels after DP and GR were elevated gradually until the 7th postoperative day. From 1 to 6 months after PD, DP and GR, the Ela levels were normal. An additional release of Ela from the remaining pancreas following direct surgical interventions to the pancreas resulted in the elevated of the plasma level of Ela in the early postoperative period. The plasma level of Ela was normalized within 2 weeks after pancreatic surgery.
authors.affiliation: First Department of Surgery, Osaka University, Medical School, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Iwase
authors.forename: M
authors.initials: M
authors.lastname: Miyata
authors.forename: Y
authors.initials: Y
authors.lastname: Tanaka
authors.forename: M
authors.initials: M
authors.lastname: Izukura
authors.forename: H
authors.initials: H
authors.lastname: Nakaba
authors.forename: H
authors.initials: H
authors.lastname: Matsuda
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D005743:Gastrectomy; D006207:Half-Life; D006801:Humans; D008297:Male; D008875:Middle Aged; D010179:Pancreas / Q000601:surgery*; D010180:Pancreatectomy; D010196:Pancreatic Elastase / Q000097:blood*; D016577:Pancreaticoduodenectomy; D011184:Postoperative Period; D013274:Stomach Neoplasms / Q000601:surgery
chemical_list: D010196:Pancreatic Elastase