Azolophenanthridines as antineoplastic agents.
Pyrrolo-, pyrazolo- and triazolo-phenanthridines were synthetized by using a Pschorrtype cyclization reaction or an intramolecular cyclization of arylnitrenium ions. By using these synthetic methods several azolo-phenanthridines, variously functionalized either in the azolo ring and in the phenanthridine moiety, were prepared. The title compounds, tested against murine leukemia cell lines, sensible and multidrug resistant, showed moderate activity with IC50 in the range 5-50 microM.
Aiello
E
E
Istituto Farmacochimico, Università degli Studi, Palermo, Italy.
Dattolo
G
G
Cirrincione
G
G
Almerico
A M
AM
Diana
P
P
Grimaudo
S
S
Mingoia
F
F
Barraja
P
P
D000818:Animals; D000970:Antineoplastic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006801:Humans; D010617:Phenanthridines / Q000138:chemical synthesis* / Q000494:pharmacology
D000970:Antineoplastic Agents; D010617:Phenanthridines