Monoallelic expression of IGF2 at the human fetal/maternal boundary.
IGF2 is expressed in both placental and decidual tissues, enabling an analysis of the parental imprinting over the fetomaternal boundary. Evidence is provided that IGF2 is monoallelically expressed in both placenta and pregnant, as well as nonpregnant, endometrium. These observations suggest that the maternally derived IGF2 allele is inactivated during germline transmission. Comparison of promoter usage in decidua and placental samples shows that the P3 promoter appears to regulated independently of the others. These observations are discussed with respect to current models of IGF2 imprinting and the hypothesized conflict of parental reproductive interests which bears on the phenomenon of parental imprinting.
Ekström
T J
TJ
Department of Clinical Neuroscience, Karolinska Hospital, Stockholm, Sweden.
Cui
H
H
Nyström
A
A
Rutanen
E M
EM
Ohlsson
R
R
D000483:Alleles; D003656:Decidua / Q000378:metabolism*; D005260:Female; D006801:Humans; D007335:Insulin-Like Growth Factor II / Q000096:biosynthesis* / Q000235:genetics; D008431:Maternal-Fetal Exchange; D010920:Placenta / Q000378:metabolism*; D011247:Pregnancy; D011401:Promoter Regions, Genetic
D007335:Insulin-Like Growth Factor II