title: Cholinergic toxicity resulting from ocular instillation of echothiophate iodide eye drops.
abstract: A patient developed a severe cholinergic syndrome from the use of echothiophate iodide ophthalmic drops, presented with profound muscle weakness and was initially given the diagnosis of myasthenia gravis. Red blood cell and serum cholinesterase levels were severely depressed and symptoms resolved spontaneously following discontinuation of the eye drops.
authors.affiliation: San Diego Regional Poison Center, UCSD Medical Center 92103-8925, USA.
authors.forename: A
authors.initials: A
authors.lastname: Manoguerra
authors.forename: C
authors.initials: C
authors.lastname: Whitney
authors.forename: R F
authors.initials: RF
authors.lastname: Clark
authors.forename: B
authors.initials: B
authors.lastname: Anderson
authors.forename: S
authors.initials: S
authors.lastname: Turchen
mesh_terms: D000368:Aged; D002802:Cholinesterases / Q000097:blood; D004456:Echothiophate Iodide / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D009123:Muscle Hypotonia / Q000139:chemically induced*; D018482:Muscle, Skeletal / Q000187:drug effects; D009157:Myasthenia Gravis / Q000097:blood / Q000175:diagnosis; D009883:Ophthalmic Solutions / Q000009:adverse effects
chemical_list: D009883:Ophthalmic Solutions; D004456:Echothiophate Iodide; D002802:Cholinesterases