A general method for selecting strains of Escherichia coli having altered spontaneous or induced mutabilities.
A simple method is described for selecting mutant strains of E. coli differing from their parent in the ability to spontaneously mutate via any mechanism. The method detects hypo- and hyper-mutators. It relies on the detection as papillae on thy colonies of second mutations either at the dra or drm locus.
Grigg
G W
GW
Peptide Technology Limited, c/o CSIRO Laboratory for Molecular Biology, North Ryde NSW, Australia.
D003470:Culture Media; D004926:Escherichia coli / Q000235:genetics*; D009154:Mutation; D013941:Thymine / Q000494:pharmacology
D003470:Culture Media; D013941:Thymine