title: Structure-activity relationships of norditerpenoid alkaloids occurring in toxic larkspur (Delphinium) species.
abstract: Fourteen norditerpenoid alkaloids present in larkspur (Delphinium) species associated with cattle poisoning on grazing land in the western United States have been toxicologically assessed in a mouse bioassay. Toxicity data for these alkaloids have established the tertiary nitrogen atom and anthranilic acid esterification as important structural features necessary to impart toxicity to lycoctonine-type norditerpenoid alkaloids. Variation in C-14 functionality of the toxic alkaloids is also a factor that influences toxicity in these compounds. The relationship of the structure-activity information of this study to previous in vitro neuromuscular studies is discussed.
authors.affiliation: Western Regional Research Center, United States Department of Agriculture, Albany, California 94710, USA.
authors.forename: G D
authors.initials: GD
authors.lastname: Manners
authors.forename: K E
authors.initials: KE
authors.lastname: Panter
authors.forename: S W
authors.initials: SW
authors.lastname: Pelletier
mesh_terms: D000470:Alkaloids / Q000737:chemistry* / Q000633:toxicity; D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000139:chemically induced; D018680:Cholinergic Antagonists; D004224:Diterpenes / Q000737:chemistry* / Q000633:toxicity; D007928:Lethal Dose 50; D008297:Male; D051379:Mice; D010939:Plant Poisoning / Q000662:veterinary; D010947:Plants, Toxic / Q000737:chemistry*; D013329:Structure-Activity Relationship; D014481:United States
chemical_list: D000470:Alkaloids; D018680:Cholinergic Antagonists; D004224:Diterpenes