title: Tissue reaction of bioabsorbable ultra high strength poly (L-lactide) rod. A long-term study in rabbits.
abstract: Bioabsorbable ultra high strength poly (L-lactide) rods, which were developed for internal fixation of fractures, were fabricated using a drawing technique. These rods were implanted in the subcutaneous tissue and in the medullary cavity of rabbits to investigate tissue reactions to poly (L-lactide) and to study their degradation process. After 18 months, histiocytes were found, and their phagocytic activity continued for as long as 42 months, with maximum activity observed between 24 and 36 months after implantation. At 62 months after intramedullary implantation, the materials had been absorbed almost completely and were replaced by bone marrow cells, with only a small amount of residual tissue reaction. At 69 months after subcutaneous implantation, the materials had been absorbed completely without any scar formation. During degradation, no foreign body giant cells were found and osteolytic expansion caused by liquid degradable materials was not seen.
authors.affiliation: Department of Orthopaedic Surgery, Kyoto University, Japan.
authors.forename: Y
authors.initials: Y
authors.lastname: Matsusue
authors.forename: S
authors.initials: S
authors.lastname: Hanafusa
authors.forename: T
authors.initials: T
authors.lastname: Yamamuro
authors.forename: Y
authors.initials: Y
authors.lastname: Shikinami
authors.forename: Y
authors.initials: Y
authors.lastname: Ikada
mesh_terms: D000818:Animals; D001672:Biocompatible Materials / Q000627:therapeutic use*; D006644:Histiocytes / Q000473:pathology; D016268:Internal Fixators; D008297:Male; D010587:Phagocytosis; D011091:Polyesters / Q000627:therapeutic use*; D019736:Prostheses and Implants; D011817:Rabbits
chemical_list: D001672:Biocompatible Materials; D011091:Polyesters; C033616:poly(lactide)