title: Endothelial cells' responses to hypoxia and reperfusion.
abstract: Our results suggest that longer periods of hypoxia lead to a deficiency of high energy phosphates. Reoxygenation leads to the formation of ROS, irrespectively of the duration of hypoxia. It might be concluded that a diminished level of intracellular high energy phosphates upon hypoxia followed by oxidative stress plays a key role in the reperfusion associated cellular dysfunctions.
authors.affiliation: Dept. of Cardiothoracic Surgery, University Hospital Vienna, Austria.
authors.forename: A
authors.initials: A
authors.lastname: Griesmacher
authors.forename: A
authors.initials: A
authors.lastname: Windischbauer
authors.forename: M M
authors.initials: MM
authors.lastname: Müller
mesh_terms: D000255:Adenosine Triphosphate / Q000378:metabolism; D015687:Cell Hypoxia; D002478:Cells, Cultured; D004730:Endothelium, Vascular / Q000378:metabolism* / Q000502:physiology; D005978:Glutathione / Q000031:analogs & derivatives / Q000378:metabolism*; D019803:Glutathione Disulfide; D006801:Humans; D015227:Lipid Peroxidation; D010725:Phosphocreatine / Q000378:metabolism*; D015424:Reperfusion; D014471:Umbilical Veins
chemical_list: D010725:Phosphocreatine; D000255:Adenosine Triphosphate; D005978:Glutathione; D019803:Glutathione Disulfide