title: Pregnancies after microsurgical correction of partial epididymal and vasal obstruction.
abstract: A group of 16 infertile patients suspected of having a partial epididymal obstruction on the basis of severe oligozoospermia, normal-sized testes and a normal serum follicle-stimulating hormone, underwent scrotal exploration. Evidence of partial obstruction of the epididymis was found in 13 cases and of the vas deferens in one case, and was supported by finding normal spermatogenesis on testicular biopsy. Vasoepididymostomy or vasovasostomy were performed, resulting in a significant improvement of semen analysis in 50% of cases and in six pregnancies in two patients. The diagnosis of partial epididymal obstruction should be considered when the above criteria are met. If pregnancies do not result when intracytoplasmic sperm injection (ICSI) is used with the ejaculated spermatozoa, a testicular biopsy followed by a microsurgical by-pass procedure should be considered whenever normal spermatogenesis is diagnosed. In all cases, the epididymal spermatozoa should be aspirated during the operation and either used immediately for insemination or stored frozen. The remarkable results of the new artificial reproduction technologies and in particular ICSI, question the indication for microsurgical correction in cases of partial epididymal obstruction.
authors.affiliation: Institute of Reproduction and Development, Monash University, Clayton, Victoria, Australia.
authors.forename: R
authors.initials: R
authors.lastname: Hauser
authors.forename: P D
authors.initials: PD
authors.lastname: Temple-Smith
authors.forename: G J
authors.initials: GJ
authors.lastname: Southwick
authors.forename: J
authors.initials: J
authors.lastname: McFarlane
authors.forename: D M
authors.initials: DM
authors.lastname: de Kretser
mesh_terms: D000328:Adult; D004822:Epididymis / Q000601:surgery*; D005260:Female; D006801:Humans; D007248:Infertility, Male / Q000209:etiology / Q000473:pathology / Q000601:surgery*; D008297:Male; D008866:Microsurgery / Q000379:methods; D008875:Middle Aged; D011247:Pregnancy; D011379:Prognosis; D012099:Reproductive Techniques; D012189:Retrospective Studies; D013076:Sperm Count; D013733:Testicular Diseases / Q000473:pathology / Q000601:surgery*; D014649:Vas Deferens / Q000601:surgery*