title: Protein design: novel metal-binding sites.
abstract: In natural proteins, metal ions play a variety of roles, including nucleophilic catalysis, electron transfer and the stabilization of protein structure. The de novo design of metal-binding sites is therefore an attractive means by which to impart proteins with novel properties and activities.
authors.affiliation: Yale University Department of Molecular Biophysics and Biochemistry, New Haven, CT 06520, USA.
authors.forename: L
authors.initials: L
authors.lastname: Regan
mesh_terms: D001665:Binding Sites; D003035:Cobalt / Q000378:metabolism; D003300:Copper / Q000378:metabolism; D006639:Histidine / Q000378:metabolism; D008670:Metals / Q000378:metabolism*; D008958:Models, Molecular; D011487:Protein Conformation; D015202:Protein Engineering; D017433:Protein Structure, Secondary; D011506:Proteins / Q000737:chemistry* / Q000378:metabolism; D015032:Zinc / Q000378:metabolism
chemical_list: D008670:Metals; D011506:Proteins; D003035:Cobalt; D006639:Histidine; D003300:Copper; D015032:Zinc