Characterization, scaling, and partial representation of neural junctions and coordinated firing patterns by dynamic similarity.
This paper presents a dynamic-similarity-based system for mathematically characterizing the functional connectivity and information flow of neural junctions. This approach allows for quantitative comparison of operations of neural junctions across systems, and an interpretation of their connectivity parameters in terms of the flow of multiunit firing patterns. The paper further uses this characterization to show how to rationally construct reduced operational models of neural junctions. Both uniformly proportional scaling and partial fragmentary representations are developed. The uniformly scaled models are better adapted to overall capacities and broader theoretical conceptualizations; the partial representations are better adapted to direct comparison with microelectrode experimentation. The characterization of information flow is based on coordinated multiunit patterns such as synfire chains or sequential configurations. The system can be applied to component parts of large composite networks including junctions with topographical patchiness and other irregularities. The characterization should be of use to anatomists, physiologists, modelers, and theorists. The theory predicts that the necessity for cooperative confluence of synaptic potentials in sending and receiving sequential configurations across topographically constrained projection fields requires the existence of functional 'pattern modules' within the topographical synaptology of the junction.
MacGregor
R J
RJ
Department of Aerospace Engineering Sciences, University of Colorado, Boulder 80309-0429, USA.
Ascarrunz
F G
FG
Kisley
M A
MA
D000818:Animals; D001698:Biomedical Engineering; D001921:Brain / Q000502:physiology; D003491:Cybernetics; D004594:Electrophysiology; D006801:Humans; D008433:Mathematics; D008959:Models, Neurological; D009424:Nervous System Physiological Phenomena; D009474:Neurons / Q000502:physiology*; D013569:Synapses / Q000502:physiology