title: A constant cathodic potential device for faradic stimulation of osteogenesis.
abstract: The purpose of this study was to design, develop, and test a device that continuously maintains a constant potential at a cathode with respect to a reference electrode by automatically varying the potential between the cathode and an anode. The ability of the device to maintain a constant cathodic potential with respect to a silver/silver chloride reference electrode is demonstrated in acute testing with a variety of electrodes as well as in chronic testing conducted until battery failure. This constant cathodic potential device permits delivery of current at an optimal cathodic potential for faradic stimulation of osteogenesis which involves a net transfer of charge through biological tissue between, typically, an implanted cathode, the negative electrode where osteogenesis occurs, and either an implanted or a topical anode, the positive electrode required only to complete the electrical circuit. Unlike present devices that maintain a constant direct current between a cathode and an anode but permit potential between said electrodes to vary, this device presents the possible detrimental effects of an undesired electrochemical reaction due to an excessive cathodic potential.
authors.affiliation: Department of Bioengineering, Clemson University, SC 29634, USA.
authors.forename: C E
authors.initials: CE
authors.lastname: Campbell
authors.forename: D V
authors.initials: DV
authors.lastname: Higginbotham
authors.forename: T J
authors.initials: TJ
authors.lastname: Baranowski
mesh_terms: D000818:Animals; D004558:Electric Stimulation / Q000295:instrumentation* / Q000379:methods*; D004566:Electrodes; D004867:Equipment Design; D010012:Osteogenesis; D011199:Potentiometry / Q000295:instrumentation / Q000379:methods; D012038:Regeneration; D013997:Time Factors