title: Tests for sensitisation in occupational medicine practice--the soy bean example.
abstract: OBJECTIVE
  To determine the prevalence of sensitisation to soy bean measured by specific IgE and skin prick tests (SPTs) and to examine the association between evidence of sensitisation to soy bean allergens and symptoms of allergic disease.
  
  
  METHODS
  Cross-sectional study. Questionnaire survey. A venous blood sample was taken for specific IgE testing, and SPTs for common allergens and soy bean dust were performed.
  
  
  METHODS
  Soy bean mill.
  
  
  METHODS
  A volunteer sample of 22 workers exposed to soy bean dust; the first 20 non-exposed workers presenting to the National Centre for Occupational Health clinic formed the control group.
  
  
  METHODS
  Immunological tests for sensitisation and symptoms of respiratory and allergic disease.
  
  
  RESULTS
  Eight of the exposed workers had positive skin reactions to either full-fat or defatted soy bean. None of the controls was SPT-positive. Eight of the exposed workers had increased levels of soy-specific IgE of whom only 4 were SPT-positive and had an increased level of soy-specific IgE. One of the control workers had an increased level of soy-specific IgE. Workers with an increased specific IgE or SPT positive to soy bean did not have more symptoms than workers with negative tests. However, work-related breathlessness was significantly higher in the exposed group (P < 0.05).
  
  
  CONCLUSIONS
  The data suggest that the immunological tests for sensitisation were not useful in identifying workers with soy bean-related disease but that tests for sensitisation were linked to exposure.
authors.affiliation: Department of National Health and Population Development, University of the Witwatersrand, Johannesburg.
authors.forename: L
authors.initials: L
authors.lastname: Roodt
authors.forename: D
authors.initials: D
authors.lastname: Rees
mesh_terms: D001985:Bronchial Provocation Tests; D003430:Cross-Sectional Studies; D006801:Humans; D007073:Immunoglobulin E / Q000032:analysis; D009784:Occupational Diseases / Q000175:diagnosis*; D011852:Radioallergosorbent Test; D012130:Respiratory Hypersensitivity / Q000175:diagnosis*; D012882:Skin Tests / Q000379:methods; D013025:Glycine max / Q000009:adverse effects*; D011795:Surveys and Questionnaires
chemical_list: D007073:Immunoglobulin E