title: [Damage to condoms caused by vaginally administered drug].
abstract: A 28-year-old woman who was treated for vaginal candidiasis with Gyno-Daktarin vaginal capsules (miconazole nitrate) became pregnant because a condom used during intercourse had ruptured. Incubation in vitro with 400 and 1200 mg miconazole nitrate vaginal capsules (Gyno-Daktarin 3 and Gyno-Daktarin I), but not miconazole nitrate vaginal cream (20 mg/g), was shown to damage rubber condoms. Patients using vaginal medicines should be aware of a possible adverse effect on rubber condoms or contraceptive diaphragms and a subsequent increased risk of pregnancy or contagious diseases such as AIDS. Fatty excipients such as glycerin, paraffin, petrolatum or Witepsol may be involved.
authors.affiliation: Stichting Landelijke Registratie Evaluatie Bijwerkingen, Tilburg.
authors.forename: R H
authors.initials: RH
authors.lastname: Meyboom
authors.forename: J S
authors.initials: JS
authors.lastname: Havinga
authors.forename: C J
authors.initials: CJ
authors.lastname: Lastdrager
authors.forename: G H
authors.initials: GH
authors.lastname: de Koning
mesh_terms: D000282:Administration, Intravaginal; D000328:Adult; D000935:Antifungal Agents / Q000008:administration & dosage* / Q000009:adverse effects; D002181:Candidiasis, Vulvovaginal / Q000188:drug therapy; D003274:Contraceptive Devices, Female / Q000592:standards*; D005260:Female; D006801:Humans; D008825:Miconazole / Q000008:administration & dosage* / Q000009:adverse effects
chemical_list: D000935:Antifungal Agents; D008825:Miconazole
vernacular_title: Beschadiging van condooms door vaginaal toegediende geneesmiddelen.