title: Grass pollen immunotherapy induces highly cross-reactive IgG antibodies to group V allergen from different grass species.
abstract: Sera from two groups of patients receiving grass pollen immunotherapy were tested on IgG reactivity with group V allergen from six different grass species. One group of patients was treated with a mixture of 10 grass species, and the other with a mixture of five. Only Lolium perenne, Dactylis glomerata, and Phleum pratense were present in both mixtures. Although Anthoxanthum odoratum and Secale cereale were absent from the mixture of five, IgG responses to Ant o V and Sec c V were comparable in both patient groups. This reactivity was inhibited for 92-99% with L. perenne extract, illustrating the cross-reactive nature of the IgG antibodies. The presence of A. odoratum and S. cereale in the mixture resulted in only minor amounts of species-specific anti-group V IgG. These results indicate that application of just one grass species in immunotherapy might be sufficient to induce an IgG response that covers other relevant Gramineae species as well.
authors.affiliation: Central Laboratory, The Netherlands Red Cross Blood Transfusion Service, University of Amsterdam.
authors.forename: R
authors.initials: R
authors.lastname: van Ree
authors.forename: P Z
authors.initials: PZ
authors.lastname: Brewczyński
authors.forename: K Y
authors.initials: KY
authors.lastname: Tan
authors.forename: H J
authors.initials: HJ
authors.lastname: Mulder-Willems
authors.forename: P
authors.initials: P
authors.lastname: Widjaja
authors.forename: S O
authors.initials: SO
authors.lastname: Stapel
authors.forename: R C
authors.initials: RC
authors.lastname: Aalberse
authors.forename: A M
authors.initials: AM
authors.lastname: Kroon
mesh_terms: D000485:Allergens / Q000276:immunology / Q000627:therapeutic use*; D000918:Antibody Specificity; D003429:Cross Reactions; D006801:Humans; D007074:Immunoglobulin G / Q000096:biosynthesis*; D007167:Immunotherapy; D008129:Lolium; D010936:Plant Extracts / Q000276:immunology / Q000627:therapeutic use*; D010940:Plant Proteins / Q000276:immunology / Q000627:therapeutic use; D006109:Poaceae; D011058:Pollen / Q000276:immunology*; D006255:Rhinitis, Allergic, Seasonal / Q000628:therapy*
chemical_list: D000485:Allergens; D007074:Immunoglobulin G; D010936:Plant Extracts; D010940:Plant Proteins