Treatment of tuberculous meningitis in Turkey.
A prospective study was performed on 72 cases of tuberculous meningitis studying various treatments. 37 patients were treated with a combination of isoniazid, rifampicin, pyrazinamide and streptomycin for 2 months, followed by a combination of isoniazid and rifampicin for 6 months. 35 patients were treated with various combinations of antituberculous drugs for 12-16 months. Disappearance of symptoms took (mean) 17 days. Mean duration of therapy for the hospitalized patients was 36 +/- 4 days. Seven (9.7%) patients died, 5 in the short-course therapy group and 2 in the long-course therapy group. Sequelae persisted in 18 (31%) cases, 8 of which cases were in the short-course therapy group and 10 in the long-course therapy group. No relapse was observed in either of the groups.
Doğanay
M
M
Department of Infectious Diseases, Erciyes University, Kayseri, Turkey.
Calangu
S
S
Turgut
H
H
Bakir
M
M
Aygen
B
B
D000293:Adolescent; D000328:Adult; D000368:Aged; D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents / Q000627:therapeutic use*; D004359:Drug Therapy, Combination / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009169:Mycobacterium tuberculosis / Q000187:drug effects; D011379:Prognosis; D011446:Prospective Studies; D013997:Time Factors; D014390:Tuberculosis, Meningeal / Q000188:drug therapy* / Q000401:mortality; D014421:Turkey / Q000453:epidemiology
D000900:Anti-Bacterial Agents; D000995:Antitubercular Agents