title: The molecular design of human IL-6 receptor antagonists.
authors.affiliation: Istituto di Ricerche di Biologia Molecolare P. Angeletti (IRBM), Pomezia, Rome, Italy.
authors.forename: A
authors.initials: A
authors.lastname: Lahm
authors.forename: R
authors.initials: R
authors.lastname: Savino
authors.forename: A L
authors.initials: AL
authors.lastname: Salvati
authors.forename: A
authors.initials: A
authors.lastname: Cabibbo
authors.forename: L
authors.initials: L
authors.lastname: Ciapponi
authors.forename: A
authors.initials: A
authors.lastname: Demartis
authors.forename: C
authors.initials: C
authors.lastname: Toniatti
authors.forename: G
authors.initials: G
authors.lastname: Paonessa
authors.forename: S
authors.initials: S
authors.lastname: Altamura
authors.forename: G
authors.initials: G
authors.lastname: Ciliberto
mesh_terms: D000595:Amino Acid Sequence; D015703:Antigens, CD; D050822:Cytokine Receptor gp130; D006801:Humans; D015850:Interleukin-6 / Q000737:chemistry* / Q000378:metabolism; D008562:Membrane Glycoproteins / Q000737:chemistry* / Q000378:metabolism; D008958:Models, Molecular; D008969:Molecular Sequence Data; D016297:Mutagenesis, Site-Directed; D017434:Protein Structure, Tertiary; D018123:Receptors, Interleukin / Q000037:antagonists & inhibitors* / Q000737:chemistry / Q000378:metabolism; D019947:Receptors, Interleukin-6; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D013329:Structure-Activity Relationship
chemical_list: D015703:Antigens, CD; C494199:IL6ST protein, human; D015850:Interleukin-6; D008562:Membrane Glycoproteins; D018123:Receptors, Interleukin; D019947:Receptors, Interleukin-6; D050822:Cytokine Receptor gp130