Human T-cell leukaemia virus.
HTLV-I has a complex and finely regulated mechanism of replication, which can be used as a model to study both cellular and viral regulation pathways in T-cells. Understanding of the underlying mechanisms involved in the pleiotropic effects of HTLV-I in the host represents a real challenge. Immunological regulation likely plays a central role in HTLV-I induced neurological disease, uveitis, and perhaps arthritis, implicating the importance of host factors as well. Viral proteins, including tax and p12' might play a role in T-cell proliferation, but the event(s) that result in the late leukaemic phase are unknown. The lack of effective therapy against HTLV-I-induced leukaemia renders prevention of viral infection the best means to eliminate HTLV-I associated diseases. Elimination or reduction of breast feeding from seropositive mothers in Japan has already produced encouraging results. In developing countries, probably only a vaccine will prevent the spread of HTLV-I infection. The molecular epidemiology of HTLV and STLV will help understand not only the phylogeny of these viruses but also the migration of human populations in the past. Episodes of horizontal transmission in the past and probably the present, indicates that nonhuman primates are the natural reservoir of HTLVs. New related viruses will likely be discovered in monkeys (and humans) in the future.
Franchini
G
G
Animal Model and Vaccine Section, National Cancer Institute, Bethesda, MD 20892, USA.
Streicher
H
H
D000818:Animals; D006800:Deltaretrovirus Infections / Q000662:veterinary / Q000821:virology; D016679:Genome, Viral; D014943:Global Health; D015490:HTLV-I Infections / Q000453:epidemiology / Q000635:transmission / Q000821:virology; D015368:Human T-lymphotropic virus 1 / Q000145:classification / Q000235:genetics / Q000472:pathogenicity / Q000502:physiology; D006801:Humans; D015459:Leukemia-Lymphoma, Adult T-Cell / Q000473:pathology / Q000821:virology; D008992:Monkey Diseases / Q000821:virology; D010802:Phylogeny; D011323:Primates; D012367:RNA, Viral / Q000235:genetics; D015303:Simian T-lymphotropic virus 1 / Q000502:physiology; D014764:Viral Proteins / Q000235:genetics / Q000502:physiology
D012367:RNA, Viral; D014764:Viral Proteins