[Immunophenotyping and clinical manifestations of NHL in Jilin Province and Akita county].
This was a comparative study of NHL in Jilin Province, China (JPC) and Akita county, Japan (ACJ). A total with 219 cases of their clinical features analyzed. The results indicated that in both areas, B-NHL predominated with a B to T cell ratio of 5.1 : 1 (JPC) and 2.4 : 1 (ACJ) respectively. Histologically B-NHL of defuse large-cell type was most commonly seen, the frequency of which was higher in JPC (61.5%) than in ACJ (37.2%). However, immunoblastic B-NHL was of common occurence in ACJ (26 out of 91 cases). In contrast, immunoblastic lympaoma of T cell lineage was very common in both areas, accounting for a half of all T-NHL. Most of the patients were treated with CHOP or COPP protocol, but the responses differred between the two phenotypes of NHL. Patients with B-NHL responded favorably to chemotherapy, with complete response (CR) in 54 of 70 treated cases (77.0%) in ACJ and 47 of 82 treated cases (57.3%) in JPC. The 3-year disease-free survial rate was 44% and 37%, respectively. The response to treatment in T-NHL patients was inferior with a CR rate of 59% in JPC cases. Only 2 in each series of patients kept the remission over 1 year.
Zhang
X
X
Department of Hematology, Third Hospital of Bethune Medical University, ChangChun.
Miura
R
R
Nakahachi
A
A
D000293:Adolescent; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002681:China; D018572:Disease-Free Survival; D005260:Female; D006801:Humans; D016130:Immunophenotyping; D007564:Japan; D016393:Lymphoma, B-Cell / Q000145:classification / Q000473:pathology*; D016403:Lymphoma, Large B-Cell, Diffuse / Q000145:classification / Q000473:pathology; D016400:Lymphoma, Large-Cell, Immunoblastic / Q000145:classification / Q000473:pathology; D016399:Lymphoma, T-Cell / Q000145:classification / Q000473:pathology*; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D012737:Sex Factors