Subcutaneous microvascular (capillary) calcification. Another basis for livedo-like skin changes?
A morbidly obese woman with acute renal failure, high serum phosphorus and slightly depressed serum calcium levels, developed areas of induration in the subcutis with associated livedo reticularis. Later, the subcutis became necrotic and the skin ulcerated. The arterioles, and notably widened occluded capillaries, were found to contain calcium and phosphorus as determined by energy dispersive spectrometry. X-ray diffraction of the subcutis in an early stage of this lesion showed that the mineral was most likely a poorly crystalline hydroxyapatite.
Chapman
D M
DM
Department of Anatomy and Neurobiology, Dalhousie University, Halifax, Nova Scotia, Canada.
Boskey
A L
AL
Tesch
M
M
Janigan
D T
DT
D000328:Adult; D002114:Calcinosis / Q000473:pathology*; D002118:Calcium / Q000032:analysis; D002196:Capillaries / Q000473:pathology / Q000648:ultrastructure; D005260:Female; D006801:Humans; D010758:Phosphorus / Q000032:analysis; D012867:Skin / Q000098:blood supply* / Q000737:chemistry; D014652:Vascular Diseases / Q000473:pathology*
D010758:Phosphorus; D002118:Calcium