[The effect of local corticosteroid therapy on ophthalmic tonus and ocular hydro- and hemodynamics in experimental inflammatory pathology].
The laboratory samples of 0.1% dexamethasone and 1% hydrocortisone eye drops which had been designed at the State Research Center of Drugs were investigated for their effects on intraocular pressure in the presence of photokeratitis caused by UV irradiation. Producing pronounced antiinflammatory effects, the daily triple instillations of corticosteroids for 9 days tended to gradually increase the ophthalmotone induced both by the imbalance of production and outflow of intraocular fluid and by ocular hemodynamic disorders associated with the enhanced blood filling of the choroidal vessels and with the higher intensity of pulse oscillations.
Chaĭka
L A
LA
Povolotskaia
V A
VA
D000818:Animals; D003907:Dexamethasone / Q000008:administration & dosage / Q000494:pharmacology*; D004353:Drug Evaluation, Preclinical; D005123:Eye / Q000187:drug effects* / Q000503:physiopathology; D006439:Hemodynamics / Q000187:drug effects; D006854:Hydrocortisone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D007429:Intraocular Pressure / Q000187:drug effects*; D007634:Keratitis / Q000188:drug therapy* / Q000209:etiology / Q000503:physiopathology; D009883:Ophthalmic Solutions; D011817:Rabbits; D013997:Time Factors; D014065:Tonometry, Ocular; D014466:Ultraviolet Rays / Q000009:adverse effects
D009883:Ophthalmic Solutions; C021650:hydrocortisone acetate; D003907:Dexamethasone; D006854:Hydrocortisone
Vliianie mestnoĭ terapii kortikosteroidami na oftal'motonus, gidro- i gemodinamiku glaza pri éksperimental'noĭ vospalitel'noĭ patologii.