title: Hemostaseological management of urological operations in patients taking aspirin using the Thrombostat 4000.
abstract: A clinical study was started in order to examine the suitability of the Thrombostat (in vitro bleeding test) (IVBT) as a diagnostic tool to prevent perioperative bleeding due to aspirin (ASA) and/or platelet function disorders of other origins. This report is based on preliminary data. Eighty three patients who had ingested ASA in the last two weeks and/or with a history of bleeding and/or documented hemorrhagic disorders requiring distinct urological operations, were included in the study. In all patients the IVBT with CaCl2, in addition to common coagulation tests, were performed. Thirteen patients stopped ASA ingestion until IVBT became normal and did not show any increased bleeding tendency. The residual patients were classified by the various operations. The following operation groups were formed: Male genitals (n = 11), inguinal/suprapubic operations (n = 7), transurethral tumor resections of the bladder (TURB) (n = 17), transurethral prostate resection (TURP) (n = 12), tumor nephrectomy (n = 8), radical prostatectomy (n = 9). Thirty six patients with a history of ASA use, but normal IVBT, served as control group (C). Thirty one patients with a history of ASA ingestion had normal in vivo bleeding times (BT) and abnormal IVBT with CaCl2 (A). Seven patients had a bleeding history and/or documented hemorrhagic disorders (B). None of the patients (A) with abnormal IVBT but normal BT displayed clinically relevant bleeding. However, the blood loss was somewhat higher compared to the controls (C), especially in patients with TURB and radical prostatectomy (not significant).(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Urologic Clinic, Klinikum, Philips University Marburg, Germany.
authors.forename: B
authors.initials: B
authors.lastname: Ulshöfer
authors.forename: V
authors.initials: V
authors.lastname: Dorst
authors.forename: V
authors.initials: V
authors.lastname: Kretschmer
authors.forename: H
authors.initials: H
authors.lastname: Köhl
authors.forename: H
authors.initials: H
authors.lastname: Riedmiller
mesh_terms: D001241:Aspirin / Q000009:adverse effects; D001760:Bleeding Time; D001780:Blood Coagulation Tests / Q000379:methods; D016063:Blood Loss, Surgical / Q000517:prevention & control*; D006488:Hemostasis, Surgical / Q000379:methods*; D006801:Humans; D008297:Male; D011517:Prothrombin Time; D014570:Urologic Diseases / Q000601:surgery*
chemical_list: D001241:Aspirin