[Platelet activating factor and pulmonary tuberculosis].
The content of platelet-activating factor (PAF) in plasma, blood, native neutrophils, in the same neutrophils after their incubation with a killed BGC culture and in the incubation medium was measured in 74 patients with various types of active pulmonary tuberculosis. Twelve healthy volunteers formed a control group. PAF was measured by the rabbit platelet aggregation technique. Higher plasma PAF levels were found in half the patients. The highest plasma PAF concentration was observed in the newly revealed patients, in cases with forming cavities in the lung tissue, in those discharged a lot of sputum Mycobacterium tuberculosis, and in those with lymphopenia. PAF content in the native neutrophils of patients was 10 times as high as that in healthy persons. Incubation with the killed BCG culture had no influence on PAF content in the control neutrophils, but greatly increased individual differences in patients. The concentration of PAF in the incubation media of stimulated neutrophils from tuberculosis patients was 3 times higher than in the controls.
Kaminskaia
G O
GO
Aladysheva
Zh I
ZhI
D000293:Adolescent; D000328:Adult; D000818:Animals; D002478:Cells, Cultured; D003470:Culture Media; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009163:Mycobacterium bovis; D009504:Neutrophils / Q000737:chemistry; D010972:Platelet Activating Factor / Q000032:analysis*; D011817:Rabbits; D014397:Tuberculosis, Pulmonary / Q000097:blood*
D003470:Culture Media; D010972:Platelet Activating Factor
Faktor aktivatsii trombotsitov i tuberkulez legkikh.