Joint scintigraphy for quantification of synovitis with 99mTc-labelled human immunoglobulin G compared to histological examination.
OBJECTIVE
This study addressed the following questions: How does 99mTc-IgG scintigraphy compare to physical examination in the detection of synovitis as determined histologically, and is 99mTc-IgG scintigraphy a sensitive detector of histologically documented synovitis activity in the absence of clinically detectable knee joint swelling?


METHODS
The results of measuring synovitis activity by physical examination and by scintigraphy with technetium-99m labelled polyclonal human immunoglobulin G (99mTc-IgG) were compared with the results of histological examination of synovial biopsies taken from the knee joints of patients with rheumatoid arthritis (n = 21), osteoarthritis (n = 9) and various other rheumatic diseases (n = 10).


RESULTS
The sensitivity of 99mTc-IgG scintigraphy in detecting synovitis activity, as determined histologically (85%), was higher than the sensitivity of joint swelling (65%). In the absence of clinically detectable knee joint swelling the sensitivity of 99mTc-IgG scintigraphy was 83%.


CONCLUSIONS
This study shows that 99mTc-IgG scintigraphy is a more sensitive method than physical examination in detecting histologically documented synovitis activity.
de Bois
M H
MH
Department of Rheumatology, University Hospital Leiden, The Netherlands.
Tak
P P
PP
Arndt
J W
JW
Kluin
P M
PM
Pauwels
E K
EK
Breedveld
F C
FC
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D004487:Edema / Q000000981:diagnostic imaging / Q000473:pathology; D005260:Female; D006801:Humans; D007074:Immunoglobulin G; D007719:Knee Joint / Q000000981:diagnostic imaging / Q000473:pathology; D008297:Male; D008875:Middle Aged; D015609:Organotechnetium Compounds; D011877:Radionuclide Imaging; D012680:Sensitivity and Specificity; D013585:Synovitis / Q000175:diagnosis / Q000000981:diagnostic imaging* / Q000473:pathology*
D007074:Immunoglobulin G; D015609:Organotechnetium Compounds; C079358:technetium TC 99m polyclonal IgG