Long term effects of ritodrine on blood pressure and heart rate of adolescents exposed during the prenatal stage.
OBJECTIVE
To determine the long term cardiovascular effects in adolescents exposed to ritodrine during prenatal stage.


METHODS
Twenty-seven ritodrine-exposed subjects and 19 controls, of both sexes, clinically healthy, and born at normal term, were evaluated for systolic blood pressure (SBP), diastolic blood pressure (DBP) and heart rate (HR) each during 48 hours, with a Colin Ambulatory monitor. Data analysis were performed by individual Cosinor method, and non-parametric Mann Whitney's test and Lamotte procedures.


RESULTS
Adolescents who were exposed to ritodrine showed losses in the HR rhythm and rising middle pulse values. Although SBP and DBP rhythm remains constant, the increase of maximum and minimum values for SBP as well as a rise of maximal rates of DBP suggest a possible hypertensive effect mediated by beta mimetic exposure.


CONCLUSIONS
This study suggests a hypertensive effect mediated by beta mimetic exposure.
Alvarez
M
M
Departamento de Obstetricia y Ginecología, Hospital Materno Infantil Teresa Herrera, Complejo Hospitalario Juan Canalejo, La Coruña, Spain.
Pita
S
S
Costas
E
E
Cupeiro
A
A
Chaves
O F
OF
García
M
M
Sola
A
A
Goyanes
V
V
D000293:Adolescent; D000375:Aging / Q000502:physiology*; D001794:Blood Pressure / Q000187:drug effects* / Q000502:physiology; D018660:Blood Pressure Monitoring, Ambulatory; D002319:Cardiovascular System / Q000187:drug effects; D002940:Circadian Rhythm / Q000502:physiology; D005260:Female; D006339:Heart Rate / Q000187:drug effects* / Q000502:physiology; D006801:Humans; D008297:Male; D008431:Maternal-Fetal Exchange / Q000502:physiology; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D012312:Ritodrine / Q000494:pharmacology*; D013997:Time Factors
D012312:Ritodrine