Organomercury (II) complexes with anti-carcinogenic agents. II. Anti-neoplastic activity.
Organomercury(II) complexes of the type, p-MeOC6H4HgL1 (I), p-NO2C6H4HgL2 (II), p-MeOC6H4HgL3 (III) and p-MeC6H4HgL4 (IV) (HL1-6-mercaptopurine, HL2-6-thioguanine, HL3-5-fluorouracil, L4-phenyldithiocarbazate) have been screened against the following cell panels: leukemia, non-small cell lung cancer, small cell lung cancer, brain cancer, melanoma, ovarian cancer and renal cancer. The variation in anti-neoplastic activity has been correlated with the structural parameters of the complexes.
Kaur
J
J
Department of Chemistry, University of Delhi, India.
Marwaha
S S
SS
Boyd
M R
MR
Sodhi
G S
GS
D000970:Antineoplastic Agents / Q000494:pharmacology*; D004354:Drug Screening Assays, Antitumor; D005472:Fluorouracil / Q000031:analogs & derivatives; D006801:Humans; D006834:Hydrazines; D015122:Mercaptopurine / Q000031:analogs & derivatives; D009941:Organomercury Compounds / Q000494:pharmacology*; D013866:Thioguanine / Q000031:analogs & derivatives; D014407:Tumor Cells, Cultured
D000970:Antineoplastic Agents; D006834:Hydrazines; D009941:Organomercury Compounds; D015122:Mercaptopurine; D013866:Thioguanine; D005472:Fluorouracil