title: Multiple endocrine neoplasia presenting as primary amenorrhea: a case report.
abstract: BACKGROUND
  Primary amenorrhea is rarely secondary to hyperprolactinemia. This case highlights the importance of obtaining a complete family history to identify patients who may have hyperprolactinemia secondary to multiple endocrine neoplasia type 1 syndrome.
  
  
  METHODS
  A 16-year-old female presented with primary amenorrhea and was noted to have hyperprolactinemia. Her family history revealed an extensive family tree consistent with multiple endocrine neoplasia type 1 syndrome. She was diagnosed subsequently with the syndrome, having both pituitary and parathyroid adenomas.
  
  
  CONCLUSIONS
  A detailed family history of patients with hyperprolactinemia secondary to a pituitary adenoma may prompt a serum calcium measurement, which may identify patients at risk for development of multiple endocrine neoplasia type 1 syndrome.
authors.affiliation: Department of Obstetrics and Gynecology, Maricopa Medical Center, Phoenix, Arizona, USA.
authors.forename: K
authors.initials: K
authors.lastname: Lythgoe
authors.forename: R
authors.initials: R
authors.lastname: Dotson
authors.forename: C M
authors.initials: CM
authors.lastname: Peterson
mesh_terms: D000293:Adolescent; D000568:Amenorrhea / Q000209:etiology*; D005260:Female; D006801:Humans; D018761:Multiple Endocrine Neoplasia Type 1 / Q000150:complications* / Q000235:genetics; D010375:Pedigree