title: Cardiovascular risk factors and alcohol consumption in France and Northern Ireland.
abstract: The levels of different lipid, lipoprotein and haemostatic variables were assessed in 615 control subjects of the ECTIM Study, defined by five groups of alcohol consumption: non-drinkers, 0 < or = 15 g/day, 15 < . < or = 36 g/day, 36 < . < or = 66 g/day and > 66 g/day. After adjustment for age, body mass index, cigarette consumption and country, alcohol consumption was associated with an increase in HDL-cholesterol (0.47 +/- 0.02 to 0.59 +/- 0.01 g/l in non-drinkers and > 66 g/day consumers, mean +/- S.E.M., P < 0.0001), apolipoproteins A-I and A-II (1.37 +/- 0.03 to 1.60 +/- 0.03 g/l and 0.32 +/- 0.01 to 0.41 +/- 0.01 g/l, respectively, P < 0.0001), LpA-I, LpA-I:A-II (0.46 +/- 0.01 to 0.50 +/- 0.01 g/l and 0.75 +/- 0.02 to 0.91 +/- 0.02 g/l, respectively, P < 0.001) and PAi-1 activity (134 +/- 11 to 177 +/- 11 U/ml, P < 0.001). Conversely, no increases were found for total and LDL-cholesterol, triglycerides, apolipoproteins B and C-III, LpE:B, LpC-III:B, fibrinogen and factor VII. Hence, among the lipid and haemostatic variables studied, only HDL parameters and PAi-1 activity were increased by alcohol consumption.
authors.affiliation: MONICA-Toulouse, INSERM U326-ORSMIP, C.H.U. Purpan, France.
authors.forename: P
authors.initials: P
authors.lastname: Marques-Vidal
authors.forename: J P
authors.initials: JP
authors.lastname: Cambou
authors.forename: V
authors.initials: V
authors.lastname: Nicaud
authors.forename: G
authors.initials: G
authors.lastname: Luc
authors.forename: A
authors.initials: A
authors.lastname: Evans
authors.forename: D
authors.initials: D
authors.lastname: Arveiler
authors.forename: A
authors.initials: A
authors.lastname: Bingham
authors.forename: F
authors.initials: F
authors.lastname: Cambien
mesh_terms: D000328:Adult; D000428:Alcohol Drinking / Q000097:blood* / Q000503:physiopathology; D001053:Apolipoproteins / Q000097:blood; D001794:Blood Pressure; D002318:Cardiovascular Diseases / Q000097:blood / Q000503:physiopathology / Q000517:prevention & control*; D002784:Cholesterol / Q000097:blood; D005602:France / Q000453:epidemiology; D006487:Hemostasis / Q000502:physiology; D006801:Humans; D008055:Lipids / Q000097:blood; D008074:Lipoproteins / Q000097:blood; D008875:Middle Aged; D009660:Northern Ireland / Q000453:epidemiology; D012189:Retrospective Studies; D012307:Risk Factors
chemical_list: D001053:Apolipoproteins; D008055:Lipids; D008074:Lipoproteins; D002784:Cholesterol