Olfactory receptor-like genes are located in the human major histocompatibility complex.
The murine major histocompatibility complex (MHC) includes sequences that are responsible for haplotype-specific odor types that, in turn, influence mating preference. We report that there are several olfactory receptor genes or pseudogenes in the Class I region of the human MHC. At least one of these genes is intact, appears to encode an mRNA, and is quite homologous to a previously reported murine olfactory receptor.
Fan
W
W
Boyer Center for Molecular Medicine, Yale University School of Medicine, New Haven, Connecticut 06510, USA.
Liu
Y C
YC
Parimoo
S
S
Weissman
S M
SM
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D018244:Chromosomes, Artificial, Yeast; D018076:DNA, Complementary / Q000235:genetics; D005796:Genes; D006801:Humans; D008285:Major Histocompatibility Complex; D008565:Membrane Proteins; D051379:Mice; D008969:Molecular Sequence Data; D005810:Multigene Family; D011544:Pseudogenes; D012333:RNA, Messenger / Q000096:biosynthesis / Q000235:genetics; D011956:Receptors, Cell Surface / Q000235:genetics*; D018035:Receptors, Odorant / Q000235:genetics*; D011993:Recombinant Fusion Proteins / Q000235:genetics; D016415:Sequence Alignment; D017386:Sequence Homology, Amino Acid; D012726:Sexual Behavior, Animal / Q000502:physiology; D013045:Species Specificity
D018076:DNA, Complementary; D008565:Membrane Proteins; C095526:OR2H2 protein, human; D012333:RNA, Messenger; D011956:Receptors, Cell Surface; D018035:Receptors, Odorant; D011993:Recombinant Fusion Proteins