title: Villous adenoma of the duodenum in a patient with familial adenomatosis coli.
abstract: A case of familial adenomatosis coli with villous adenoma of the third portion of the duodenum, which falls in the category of a Gardner's syndrome, is described. The patient, who had complained of an abdominal mass which had been diagnosed as a desmoid tumor after surgical resection, had numerous adenomatous polyps throughout the colon confirmed by colonoscopy with biopsy. Endoscopic examination of the upper gastrointestinal tract revealed fundic gland polyposis in the stomach and numerous small adenomas in the duodenum. In addition, there was a pedunculated polyp in the third portion of his duodenum, measuring 30 mm in diameter, the surface of which had a cauliflowerlike appearance. The polyp was removed with the electrocautery snare and was histologically diagnosed as villous adenoma. Our case report supports the concept that villous adenoma, which possesses a high malignant potential, may occur in the upper gastrointestinal tract in patients with familial adenomatosis coli, and careful examination of the upper gastrointestinal tract including the distal duodenum seems to be necessary in the follow-up patients with this disease.
authors.affiliation: Department of Internal Medicine II, Faculty of Medicine, Kyushu University, Fukuoka, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Doi
authors.forename: M
authors.initials: M
authors.lastname: Iida
authors.forename: N
authors.initials: N
authors.lastname: Kohrogi
authors.forename: T
authors.initials: T
authors.lastname: Yao
authors.forename: M
authors.initials: M
authors.lastname: Fujishima
mesh_terms: D018253:Adenoma, Villous / Q000473:pathology; D000328:Adult; D004379:Duodenal Neoplasms / Q000473:pathology; D005736:Gardner Syndrome / Q000175:diagnosis / Q000473:pathology* / Q000601:surgery; D006801:Humans; D008297:Male