[PTCA-induced myocardial ischemia for detection salvaged myocardium after thrombolytic therapy of acute myocardial infarct].
In 43 patients (ages 55.8 +/- 9.0 years) with myocardial infarction treated with thrombolytic therapy presenting with one-vessel coronary artery disease, the monitoring-ECGs during PTCA (17.0 +/- 12.7 days after infarct) were analyzed. Patients with ST-segment deviations > or = 0.1 mV (group A, n = 33) were compared with those < 0.1 mV (group B, n = 10). To answer the question, if these ischemic signs might be interpreted as salvaged myocardium, parameters of infarct size were evaluated. The maximal CK-activity in group A was 867 +/- 567 IU/l, in group B 1452 +/- 992 IU/l (p < 0.05), whereas the maximal GOT-activity was 113 +/- 69 IU/l and 174 +/- 102 UI/l (p < 0.05). The number of pathologic segments of the ventriculographies in the acute phase were 9 +/- 2 and 14 +/- 3 (p < 0.05), shortly after PTCA, 12 +/- 2 and 16 +/- 2 (p = 0.06), and after 6 months, 11 +/- 4 and 13 +/- 1 (N.S.). At the same time points EDV was analyzed in both groups and revealed the following: 103 +/- 20 ml, 98 +/- 21 ml, 104 +/- 23 ml and 103 +/- 25 ml (N.S.), 101 +/- 21 ml (N.S.), 116 +/- 46 ml (N.S.).(ABSTRACT TRUNCATED AT 250 WORDS)
Nixdorff
U
U
II. Medizinische Klinik und Poliklinik, Johannes-Gutenberg-Universitätsklinikum, Mainz.
Stein
R
R
Erbel
R
R
Rupprecht
H J
HJ
Spiecker
M
M
Meyer
J
J
D000328:Adult; D000368:Aged; D000787:Angina Pectoris / Q000188:drug therapy / Q000503:physiopathology; D015906:Angioplasty, Balloon, Coronary; D004562:Electrocardiography; D005080:Exercise Test / Q000187:drug effects; D005260:Female; D005343:Fibrinolytic Agents / Q000008:administration & dosage; D006329:Heart Conduction System / Q000187:drug effects / Q000503:physiopathology; D006801:Humans; D008297:Male; D008875:Middle Aged; D009200:Myocardial Contraction / Q000187:drug effects / Q000502:physiology; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000503:physiopathology; D017202:Myocardial Ischemia / Q000188:drug therapy* / Q000503:physiopathology; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis* / Q000503:physiopathology; D013318:Stroke Volume / Q000187:drug effects / Q000502:physiology; D015912:Thrombolytic Therapy; D014022:Tissue Survival / Q000187:drug effects / Q000502:physiology
D005343:Fibrinolytic Agents
PTCA-induzierte Myokardischämie zum Nachweis von gerettetem Myokard nach thrombolytischer Therapie des akuten Myokardinfarktes.