title: Urinary tract infections in cocaine-exposed infants.
abstract: Infants prenatally exposed to cocaine are reported to have an increased incidence of genitourinary tract abnormalities. Because children with genitourinary tract anomalies have a higher incidence of urinary tract infections, a prospective study was performed to investigate the incidence of urinary tract infections in cocaine-exposed infants. The urine culture results were positive in 14% of 110 cocaine-exposed infants studied. This is significantly higher than the 4% infection rate in our control group and higher than the previously reported incidence of 0.1% to 3% urinary tract infections in newborns. Although the incidence of abnormal results from renal ultrasonography was high (16%), abnormal results did not correlate with the development of a urinary tract infection. Other laboratory tests also did not predict urine culture abnormalities. Urine culture screening is recommended for all cocaine-exposed infants.
authors.affiliation: Department of Pediatrics, Columbus-Cabrini Medical Center, Chicago, IL, USA.
authors.forename: E K
authors.initials: EK
authors.lastname: Gottbrath-Flaherty
authors.forename: R
authors.initials: R
authors.lastname: Agrawal
authors.forename: V
authors.initials: V
authors.lastname: Thaker
authors.forename: D
authors.initials: D
authors.lastname: Patel
authors.forename: K
authors.initials: K
authors.lastname: Ghai
mesh_terms: D016022:Case-Control Studies; D003042:Cocaine / Q000009:adverse effects; D005260:Female; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D007668:Kidney / Q000000981:diagnostic imaging; D008297:Male; D011247:Pregnancy; D011248:Pregnancy Complications; D011297:Prenatal Exposure Delayed Effects; D011446:Prospective Studies; D019966:Substance-Related Disorders / Q000150:complications*; D014463:Ultrasonography; D014552:Urinary Tract Infections / Q000139:chemically induced* / Q000453:epidemiology / Q000652:urine
chemical_list: D003042:Cocaine