[Effect of somatostatin and GABA on long-term potentiation in hippocampal CA1 are in rats].
AIM. To study the effect of somatostatin (SS) and GABA on the long-term potentiation (LTP) of hippocampal CA1 area in rats.


METHODS
Active avoidance response (AAR) of shuttle-box was recorded and population spikes (PS) were taken as indices of LTP.


RESULTS
Increased percentages of PSA (PS amplitude, in AAR-acquired rats are more than 100%; After intrahippocampal injection (i.h.) of SS (1 g L-1), increased percentages of PSA exhibited above 120%. Increased percentages of PSA were significantly decreased (< 10%, n = 3) and even caused no PS (n = 8) by ih cysteamine (Cys, 20 g L-1, the depletor of SS); i.h. GABA (200 g L-1) indicated that the increased percentages of PSA are less than 30%, GABA weakened the effect of SS on LTP.


CONCLUSIONS
SS enhance hippocampal LTP but GABA decrease it; they may influence each other to regulate the hippocampal synaptic transmission in the process of learning and memory.
Ji
W Q
WQ
Department of Physiology, Third Military Medical University, Chongqing, China.
Zhang
C C
CC
Zhang
G H
GH
D000818:Animals; D001362:Avoidance Learning / Q000187:drug effects; D003538:Cystamine / Q000494:pharmacology; D005071:Evoked Potentials / Q000187:drug effects; D005260:Female; D006624:Hippocampus / Q000502:physiology*; D017774:Long-Term Potentiation / Q000187:drug effects*; D008568:Memory / Q000187:drug effects; D008845:Microinjections; D051381:Rats; D017208:Rats, Wistar; D013004:Somatostatin / Q000494:pharmacology*; D005680:gamma-Aminobutyric Acid / Q000494:pharmacology*
D013004:Somatostatin; D005680:gamma-Aminobutyric Acid; D003538:Cystamine