Regional localization of the human vitronectin receptor alpha subunit gene (VNRA) to chromosome 2q31-->q32.
The vitronectin receptor (av:beta 3; CD51/CD61), a member of the beta 3 integrin subfamily (cytoadhesins), functions as a receptor for a group of proteins that includes vitronectin, fibrinogen, thrombospondin, and von Willebrand factor. The human locus for the av gene (VNRA) was previously mapped to the long arm of chromosome 2 by DNA analysis of somatic cell hybrids. By using fluorescence in situ hybridization, coupled with GTG-banding, we have regionally mapped the human av gene to chromosome 2q31-->q32. An identical location was previously reported for the human gene coding for the integrin VLA-alpha 4 subunit (CD49D). These data, therefore, suggest the existence of a cluster of integrin genes at this chromosomal location.
Fernández-Ruiz
E
E
Servicio de Immunología, Hospital de la Princesa, Universidad Autónoma de Madrid, Spain.
Pardo-Manuel de Villena
F
F
Rodríguez de Córdoba
S
S
Sánchez-Madrid
F
F
D002871:Chromosome Banding; D002874:Chromosome Mapping; D002889:Chromosomes, Human, Pair 2; D004247:DNA; D005340:Fibrinogen / Q000378:metabolism; D006023:Glycoproteins / Q000378:metabolism; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D016023:Integrins / Q000235:genetics* / Q000378:metabolism; D010980:Platelet Membrane Glycoproteins / Q000378:metabolism; D016024:Receptors, Cytoadhesin / Q000235:genetics* / Q000378:metabolism; D019030:Receptors, Vitronectin; D019699:Thrombospondins; D019096:Vitronectin; D014841:von Willebrand Factor / Q000378:metabolism
D006023:Glycoproteins; D016023:Integrins; D010980:Platelet Membrane Glycoproteins; D016024:Receptors, Cytoadhesin; D019030:Receptors, Vitronectin; D019699:Thrombospondins; D019096:Vitronectin; D014841:von Willebrand Factor; D005340:Fibrinogen; D004247:DNA