[A morphofunctional evaluation of the immunomodulating action of nitrosomethylurea].
The thymuses and spleens from healthy and tumor-bearing (leukemia P 388 and Lewis' carcinoma) were morphometrically studied after a single administration of the antitumor agent nitrosomethylurea in doses of 96 and 4 mg/kg. When used both in the high and low doses, nitrosomethylurea had an immunomodulating effect, causing the activation of cell-mediated immunity in healthy and tumor-bearing (in early malignancy) animals when given in the small dose.
Potapov
Iu N
IuN
Khaleev
D V
DV
Krutova
T V
TV
D000276:Adjuvants, Immunologic / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D018827:Carcinoma, Lewis Lung / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D004305:Dose-Response Relationship, Drug; D004354:Drug Screening Assays, Antitumor; D005260:Female; D007111:Immunity, Cellular / Q000187:drug effects; D007941:Leukemia P388 / Q000188:drug therapy / Q000276:immunology / Q000503:physiopathology; D008297:Male; D008770:Methylnitrosourea / Q000008:administration & dosage / Q000494:pharmacology*; D051379:Mice; D008810:Mice, Inbred C57BL; D008811:Mice, Inbred DBA; D009368:Neoplasm Transplantation; D013154:Spleen / Q000187:drug effects / Q000276:immunology / Q000503:physiopathology; D013950:Thymus Gland / Q000187:drug effects / Q000276:immunology / Q000503:physiopathology; D013997:Time Factors
D000276:Adjuvants, Immunologic; D008770:Methylnitrosourea
Morfofunktsional'naia otsenka immunomoduliruiushchego deĭstviia nitrozometilmocheviny.