Anorectic activity of NG-nitro-L-arginine, an inhibitor of brain nitric oxide synthase, in obese Zucker rats.
We investigated the effects of NG-nitro-L-arginine (L-NO Arg) administration (12.5, 25 and 50 mg/kg i.p.) on food consumption and body weight of male obese Zucker rats (fa/fa) and in their lean age-matched controls (FA/?; FA/FA), both groups aged 14 weeks. Acute or repeated administration of L-NO Arg reduced food intake and body weight in both obese and lean rats. However the lean rats showed tolerance to the L-NO Arg effects after 5 days of treatment. L-NO Arg anorexia was suppressed by pretreatment with metergoline. These results suggest that L-NO Arg may represent a new anorectic drug.
Squadrito
F
F
Institute of Pharmacology, School of Medicine, University of Messina, Italy.
Calapai
G
G
Cucinotta
D
D
Altavilla
D
D
Zingarelli
B
B
Ioculano
M
M
Urna
G
G
Sardella
A
A
Campo
G M
GM
Caputi
A P
AP
D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D004435:Eating / Q000187:drug effects; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D019001:Nitric Oxide Synthase; D019335:Nitroarginine; D009765:Obesity / Q000201:enzymology*; D051381:Rats; D011924:Rats, Zucker; D016713:Ritanserin / Q000494:pharmacology; D012702:Serotonin Antagonists
D001067:Appetite Depressants; D012702:Serotonin Antagonists; D016713:Ritanserin; D008711:Metergoline; D019335:Nitroarginine; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases