title: Isoflurane and sevoflurane produce a dose-dependent reduction in the shivering threshold in rabbits.
abstract: All general anesthetics markedly impair thermoregulatory responses; nonetheless, sufficient hyperthermia or hypothermia will trigger most protective reflexes. Shivering, however, remains an exception among thermo-regulatory responses: it is common during postanesthetic recovery, but is rare at typical anesthetic concentrations. This observation suggests that general anesthesia impairs shivering far more than other thermoregulatory defenses. Accordingly, we tested the hypothesis that low concentrations of isoflurane and sevoflurane would virtually obliterate shivering. Japanese white rabbits were anesthetized with isoflurane or sevoflurane at end-tidal concentrations of 0.2, 0.3, and 0.4 minimum alveolar anesthetic concentration (MAC) (n = 6 in each group); the normal core temperature for these rabbits is approximately 39 degrees C. Core temperatures were subsequently reduced by a water-perfused thermode positioned in the colon. The core temperature triggering shivering identified the threshold for this response. Five of the six rabbits given 0.2 MAC isoflurane shivered at a mean core temperature of 36.3 +/- 0.3 degrees C (mean +/- SD), and one rabbit failed to shiver at a minimum core temperature of 35.0 degrees C. Four of the six rabbits given 0.3 MAC isoflurane shivered at a mean core temperature of 36.2 +/- 0.6 degrees C, and two of these rabbits failed to shiver at a minimum core temperature of 35.0 degrees C. However, no rabbit given 0.4 MAC isoflurane shivered, even at minimum core temperatures of 35.0 degrees C. All of the rabbits given 0.2 MAC sevoflurane shivered at a mean core temperature of 36.6 +/- 0.7 degrees C.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Anesthesia, Yamanashi Medical University, Japan.
authors.forename: K
authors.initials: K
authors.lastname: Hanagata
authors.forename: T
authors.initials: T
authors.lastname: Matsukawa
authors.forename: D I
authors.initials: DI
authors.lastname: Sessler
authors.forename: T
authors.initials: T
authors.lastname: Miyaji
authors.forename: T
authors.initials: T
authors.lastname: Funayama
authors.forename: M
authors.initials: M
authors.lastname: Koshimizu
authors.forename: S
authors.initials: S
authors.lastname: Kashimoto
authors.forename: T
authors.initials: T
authors.lastname: Kumazawa
mesh_terms: D000777:Anesthetics / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004987:Ethers / Q000494:pharmacology*; D007530:Isoflurane / Q000494:pharmacology*; D008297:Male; D008738:Methyl Ethers; D011817:Rabbits; D012684:Sensory Thresholds / Q000187:drug effects*; D000077149:Sevoflurane; D012768:Shivering / Q000187:drug effects*
chemical_list: D000777:Anesthetics; D004987:Ethers; D008738:Methyl Ethers; D000077149:Sevoflurane; D007530:Isoflurane