Multiple mechanisms of receptor-G protein signaling specificity.
The hormone-receptor-G protein complex transduces extracellular information into intracellular signals that ultimately regulate cellular functions in a highly specific manner. There are hundreds of receptor types that transduce signals through a relatively limited repertoire of heterotrimeric G proteins. Linear models of signaling specificity that require specific and highly selective coupling of hormone to receptor to G protein have proven inadequate to explain how highly particular signals are funneled through the G protein "bottleneck." Recent studies have uncovered a plethora of mechanisms that contribute to signaling specificity. This review focuses on the mechanisms that contribute to specificity in the interactions of receptors with G proteins.
Raymond
J R
JR
D017398:Alternative Splicing; D000818:Animals; D005246:Feedback; D019204:GTP-Binding Proteins / Q000502:physiology*; D006801:Humans; D011942:Receptors, Adrenergic, alpha / Q000502:physiology; D011956:Receptors, Cell Surface / Q000235:genetics / Q000502:physiology*; D017481:Receptors, Somatostatin / Q000502:physiology; D015398:Signal Transduction; D013347:Subcellular Fractions / Q000378:metabolism
D011942:Receptors, Adrenergic, alpha; D011956:Receptors, Cell Surface; D017481:Receptors, Somatostatin; D019204:GTP-Binding Proteins