Clinical features and pharmacologic treatment of Paget's disease.
Paget's disease of the bone is characterized by a focal increase in the rate of bone turnover, which goes through phases of activity and quiescence. Most patients are asymptomatic. The two cardinal features are pain and deformities, and many complications may arise. Diphosphonates and calcitonin are the main therapeutic modalities.
Hamdy
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Division of Geriatric Medicine, James H. Quillen College of Medicine, East Tennessee State University, Johnson City, USA.
D002318:Cardiovascular Diseases / Q000209:etiology; D006801:Humans; D009422:Nervous System Diseases / Q000209:etiology; D010001:Osteitis Deformans / Q000150:complications / Q000175:diagnosis / Q000188:drug therapy / Q000473:pathology; D012516:Osteosarcoma / Q000209:etiology