Adenosine and ventricular automaticity.
Adenosine is considered a cardiodepressant agent due to its negative chronotropic and inotropic effects. However, the effect of adenosine on ventricular automaticity is less well established since both an increase and a decrease in ventricular automaticity have been reported. The experimental and clinical evidence dealing with the effects of adenosine on ventricular automaticity as well as the possible mechanisms involved, is presented in this review.
Hernández
J
J
Department of Pharmacology, Medical School, Murcia, Spain.
Ribeiro
J A
JA
D000241:Adenosine / Q000494:pharmacology*; D000818:Animals; D002395:Catecholamines / Q000502:physiology; D006801:Humans; D018047:Receptors, Purinergic P1 / Q000187:drug effects; D016276:Ventricular Function / Q000187:drug effects*
D002395:Catecholamines; D018047:Receptors, Purinergic P1; D000241:Adenosine