B and T lymphocyte subsets in fetal and cord blood: age-related modulation of CD1c expression.
Peripheral blood lymphocytes from fetal, term and adult subjects were analyzed with a panel of B- and T-lymphoid differentiation markers. CD1c +ve and CD5 +ve B cell (IgM +ve) percentage in fetal, cord and adult blood decreased significantly. Fetal and cord blood contained less CD2+ and CD3+ T lymphocytes and a higher percentage of CD38 +ve cells than adult blood. The phenotypic changes occurring during perinatal age in humans relate to the changes in the functional activities of the B and T lymphoid subsets from fetal to postnatal age.
Plebani
A
A
1st Clinica Pediatrica G. e. D. DeMarchi, Università di Milano, Italy.
Proserpio
A R
AR
Guarneri
D
D
Buscaglia
M
M
Cattoretti
G
G
D000328:Adult; D000367:Age Factors; D015703:Antigens, CD / Q000032:analysis / Q000096:biosynthesis* / Q000097:blood; D018949:Antigens, CD1; D016175:B-Lymphocyte Subsets / Q000276:immunology*; D005312:Fetal Blood / Q000166:cytology* / Q000276:immunology; D005434:Flow Cytometry; D005865:Gestational Age; D006801:Humans; D016130:Immunophenotyping; D007231:Infant, Newborn; D007234:Infant, Premature / Q000097:blood; D016176:T-Lymphocyte Subsets / Q000276:immunology*
D015703:Antigens, CD; D018949:Antigens, CD1