title: Leukotriene B4 as a marker of cerebral dysfunction.
abstract: It has been postulated that leukotriene B4 is involved in the pathogenesis of postischaemic cerebral oedema. We set out to determine if a relationship exists between jugular bulb leukotriene B4 and other indicators of cerebral ischaemia. No association could be demonstrated for either intracranial pressure, jugular bulb blood oxygen saturation or lactate oxygen index. Our results provide insufficient evidence to suggest that measurement of leukotriene B4 has any place in the management of head-injured patients.
authors.affiliation: Department of Anaesthesia and Intensive Care, Faculty of Medicine, Chinese University of Hong Kong, Prince of Wales Hospital, Shatin, New Territories.
authors.forename: A P
authors.initials: AP
authors.lastname: Kendall
authors.forename: E S
authors.initials: ES
authors.lastname: Lin
authors.forename: T E
authors.initials: TE
authors.lastname: Oh
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D015415:Biomarkers / Q000097:blood; D002545:Brain Ischemia / Q000097:blood*; D006259:Craniocerebral Trauma / Q000097:blood* / Q000503:physiopathology; D005260:Female; D006801:Humans; D007427:Intracranial Pressure / Q000502:physiology; D007601:Jugular Veins; D007773:Lactates / Q000097:blood; D019344:Lactic Acid; D007975:Leukotriene B4 / Q000097:blood*; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood
chemical_list: D015415:Biomarkers; D007773:Lactates; D007975:Leukotriene B4; D019344:Lactic Acid; D010100:Oxygen