Novel pyrrolo- and thiazolo-imidazoles.
In this study, the synthesis and the stereochemical features of novel tricyclic derivatives containing an imidazole nucleus are described. The biological properties of the synthesized compounds as well as some aspects of the structure activity relationship are also discussed.
Chimirri
A
A
Dipartimento Farmaco-Chimico, Università di Messina.
Grasso
S
S
Monforte
A M
AM
Monforte
P
P
Zappalà
M
M
D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D055598:Chemical Phenomena; D002627:Chemistry, Physical; D006801:Humans; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D011758:Pyrroles / Q000138:chemical synthesis* / Q000494:pharmacology; D011963:Receptors, GABA-A / Q000187:drug effects*; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000998:Antiviral Agents; D007093:Imidazoles; D011758:Pyrroles; D011963:Receptors, GABA-A; D013844:Thiazoles