Tissue-specific expression of a Drosophila calcium-activated potassium channel.
The Drosophila slowpoke (slo) gene encodes a subunit of a CAK channel homologous to the vertebrate BK channel. We have examined slo expression throughout development. It is expressed in muscle cells, neurons of the CNS and PNS, mushroom bodies, a limited number of cells in embryonic and larval midgut and in epithelial-derived tracheal cells. The promoter has been cloned and shown to direct expression in the same pattern as the endogenous gene in both neural and epithelial-derived cells. During pupariation and embryogenesis, slo is expressed in muscles many hours prior to the appearance of functional channels.
Becker
M N
MN
Department of Zoology, University of Texas at Austin 78712-1064, USA.
Brenner
R
R
Atkinson
N S
NS
D000818:Animals; D001921:Brain / Q000378:metabolism; D002118:Calcium / Q000502:physiology*; D004064:Digestive System / Q000378:metabolism; D004330:Drosophila / Q000235:genetics / Q000254:growth & development / Q000378:metabolism*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D007814:Larva / Q000378:metabolism; D009132:Muscles / Q000378:metabolism; D015221:Potassium Channels / Q000235:genetics / Q000378:metabolism*; D011401:Promoter Regions, Genetic; D011679:Pupa / Q000378:metabolism; D014018:Tissue Distribution; D014132:Trachea / Q000166:cytology / Q000378:metabolism
D015221:Potassium Channels; D002118:Calcium