Patent ductus arteriosus. Clinical relevance of prostaglandins and prostaglandin inhibitors in PDA pathophysiology and treatment.
This article presents a comprehensive review of the patent ductus arteriosus which so often affects the premature neonate. Included are a discussion of the unique anatomy and physiology of the ductus, a review of the mechanisms involved in normal closure, and factors leading to persistent patency. Various therapeutic options also are discussed, including some new and innovative approaches.
Hammerman
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Department of Neonatology, Shaare Zedek Medical Center, Hebrew University, Jerusalem, Israel.
D004373:Ductus Arteriosus / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology; D004374:Ductus Arteriosus, Patent / Q000188:drug therapy* / Q000473:pathology / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007213:Indomethacin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D007231:Infant, Newborn; D007234:Infant, Premature; D007235:Infant, Premature, Diseases / Q000188:drug therapy* / Q000503:physiopathology*; D010100:Oxygen / Q000097:blood; D011247:Pregnancy; D011453:Prostaglandins / Q000502:physiology*
D011453:Prostaglandins; D010100:Oxygen; D007213:Indomethacin