Isolation and structure of two novel muscarinic receptor antagonists.
The structures of two novel muscarinic receptor antagonists, 1 and 2, were determined by their spectral data and high-resolution mass measurements of their degradation products. Both are aliphatic long-chain compounds and contain amide and keto functionalities. The major microbial metabolite [1] contains three terminal guanidino groups and the minor compound [2] has two terminal guanidino groups.
Hedge
V R
VR
Schering-Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA.
Silver
J E
JE
Patel
M G
MG
Gullo
V P
VP
Das
P R
PR
Puar
M S
MS
D000191:Actinomycetaceae / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D018727:Muscarinic Antagonists / Q000302:isolation & purification / Q000494:pharmacology*; D011813:Quinuclidinyl Benzilate; D011976:Receptors, Muscarinic / Q000187:drug effects*; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate