[Influence of cytokines on neuroendocrine functions during immune response. Mechanisms involved and neuronal pathways].
The action of immune-system derived cytokines to stimulate release of corticotropin-releasing factor (CRF) from the hypothalamus and the consequent elaboration of ACTH and corticosteroids release has provided an especially useful model to investigate the nature of the inter-communication of neuroendocrine and immunological pathways. Substantial evidence also exists to support the production of cytokines within the mammalian central nervous system (CNS). These brain-derived cytokines may function to regulate specific challenges, such as immunological, trauma-induced, physical, and emotional stress, to the CNS as well as to receive input from immune signals in the systemic circulation. The mechanisms involved in the effects of cytokines, such as interleukin-1 (IL-1) alpha and beta, on selective neuroendocrine functions are presented in this review. Particularly, the neuronal circuitries used by IL-1 of peripheral and central origin to modulate neuroendocrine CRF motoneurons and the activity of the hypothalamic-pituitary-adrenal (HPA) are described. The influence of an immune activation on neuroendocrine functions and brain neuronal activation is also presented.
Rivest
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Laboratoire d'endocrinologie moléculaire, Centre de recherche du CHUL, Québec, Canada.
Lacroix
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D000818:Animals; D000917:Antibody Formation; D003346:Corticotropin-Releasing Hormone / Q000378:metabolism; D016207:Cytokines / Q000494:pharmacology*; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007111:Immunity, Cellular; D007375:Interleukin-1 / Q000494:pharmacology; D009474:Neurons / Q000378:metabolism* / Q000502:physiology; D009490:Neurosecretory Systems / Q000187:drug effects* / Q000378:metabolism* / Q000502:physiology; D010913:Pituitary-Adrenal System / Q000378:metabolism; D051381:Rats
D016207:Cytokines; D007375:Interleukin-1; D003346:Corticotropin-Releasing Hormone
Influence des cytokines sur les fonctions neuroendocriniennes durant la réponse immunitaire. Mécanismes impliqués et voies neuronales empruntées.