Electrophysiologic effects following acute intracochlear direct current stimulation of the guinea pig cochlea.
Auditory brain stem responses to both acoustic (auditory brain stem response [ABR]) and electrical (electrically evoked auditory brain stem response [EABR]) stimuli, as well as the frequency-specific compound action potential (CAP), were recorded before and periodically following continuous intracochlear DC stimulation (2, 7, and 12 microA) for 2 hours in normal-hearing guinea pigs, by means of a banded intracochlear electrode array. Click-evoked ABR, frequency-specific CAP, and the EABR input-output function remained generally unchanged following stimulation at 2 microA DC. However, following stimulation at 7 and 12 microA, a significant decrement of the amplitude of the click-evoked ABR, frequency-specific CAP, and electrophonic component of the EABR was observed, while there was an increase in the amplitude of the EABR, associated with direct electrical stimulation of the auditory nerve.
Tykocinski
M
M
Department of Otolaryngology, University of Melbourne.
Shepherd
R K
RK
Clark
G M
GM
D000161:Acoustic Stimulation; D000818:Animals; D003051:Cochlea / Q000502:physiology*; D004558:Electric Stimulation; D005072:Evoked Potentials, Auditory; D016057:Evoked Potentials, Auditory, Brain Stem; D006168:Guinea Pigs