Stimulus properties of some analogues of 4-methylaminorex.
The stimulus properties of aminorex and analogues of 4-methylaminorex, namely (4S,5S)-4-methylaminorex, N-methyl-(4S,5S)-4-methylaminorex, and the regioisomeric (R)- and (S)-2-amino-4-phenyl-2-oxazoline (rexamino) were compared in rats trained to distinguish (S)-amphetamine (1 mg/kg) from saline. The first three compounds, aminorex, (4S,5S)-4-methylaminorex, and N-methyl-(4S,5S)-4-methylaminorex shared discriminative stimulus effects with amphetamine, although the stimulus properties for racemic aminorex were less than those of the other two compounds. The two regioisomers, (R)- and (S)-rexamino, produced only partial generalisation to the amphetamine.
Russell
B R
BR
School of Pharmacy, University of Otago, Dunedin, New Zealand.
Beresford
R A
RA
Schmierer
D M
DM
McNaughton
N
N
Clark
C R
CR
D000661:Amphetamine / Q000494:pharmacology; D000818:Animals; D000697:Central Nervous System Stimulants / Q000494:pharmacology*; D003216:Conditioning, Operant / Q000187:drug effects; D004193:Discrimination Learning / Q000187:drug effects; D004192:Discrimination, Psychological / Q000187:drug effects*; D005260:Female; D005795:Generalization, Stimulus / Q000187:drug effects; D013287:Illicit Drugs / Q000494:pharmacology*; D010080:Oxazoles / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012055:Reinforcement Schedule; D013237:Stereoisomerism
D000697:Central Nervous System Stimulants; D013287:Illicit Drugs; D010080:Oxazoles; C000081:4-methylaminorex; D000661:Amphetamine