title: Juvenile myoclonic epilepsy and human leukocyte antigens.
abstract: The idiopathic generalized epilepsies (IGE) occur with a high aggregation within families. Juvenile myoclonic epilepsy (JME) is recognized as a commonly occurring form of idiopathic generalized epilepsy. A possible association between JME and HLA antigens was investigated by serological typing of human leukocyte antigens (HLA) class I antigens and by DNA oligotyping of class II antigens. Twenty-four patients and 129 controls, all Caucasians of Scandinavian descent, were tested. Uncorrected there was a significant positive association (Relative risk (RR) = 8.07) to B17 and a significant negative association (RR = 0.13) to B8 as well as DRB1*3. The negative association to DQ alleles DQA1*0501 and DQB1*0201, which are in strong linkage disequilibrium with the alleles B8 and DRB1*3, was weaker and not significant, thus giving no clue as to a primary HLA-DQ association of JME.
authors.affiliation: Department of Immunology, Trondheim University Hospital, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Moen
authors.forename: E
authors.initials: E
authors.lastname: Brodtkorb
authors.forename: R P
authors.initials: RP
authors.lastname: Michler
authors.forename: A
authors.initials: A
authors.lastname: Holst
mesh_terms: D000293:Adolescent; D000328:Adult; D000483:Alleles; D002874:Chromosome Mapping; D004831:Epilepsies, Myoclonic / Q000235:genetics*; D005260:Female; D015395:Histocompatibility Antigens Class I / Q000235:genetics*; D000949:Histocompatibility Antigens Class II / Q000235:genetics*; D006801:Humans; D015810:Linkage Disequilibrium; D008297:Male; D008875:Middle Aged; D016133:Polymerase Chain Reaction
chemical_list: D015395:Histocompatibility Antigens Class I; D000949:Histocompatibility Antigens Class II