title: [Pathological and immunohistochemical studies on primary nasal mucosal malignant melanoma].
abstract: The pathological and immunohistochemical features of primary nasal mucosal malignant melanoma (PNMMM) were reported in 40 cases. The results showed that approximate 70% of PNMMM was polypoid. The principal features were the mixed existance of different cellular patterns and morphologies. Immunohistochemically, PNMMM reactivity to S-100 protein and vimentin was 90% and 77.5%, respectively, along with no reactivity to Keratin. We believe that PNMMM may arise from preexistant melocytes in nasal mucosa. Histological pleomorphism and immunohistochemical reactivity to S-100 protein and vimentin were of importance for diagnosis of PNMMM, especially for the amelanotic type.
authors.affiliation: First Affiliated Hospital, Wenzhou Medical College.
authors.forename: J
authors.initials: J
authors.lastname: Xu
authors.forename: L
authors.initials: L
authors.lastname: Chen
authors.forename: P
authors.initials: P
authors.lastname: Wang
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged; D009297:Nasal Mucosa / Q000737:chemistry / Q000473:pathology*; D009669:Nose Neoplasms / Q000737:chemistry / Q000473:pathology*; D012189:Retrospective Studies; D009418:S100 Proteins / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
chemical_list: D009418:S100 Proteins; D014746:Vimentin