Absorption behavior of sulpiride described using Weibull functions.
Deconvolution absorption profiles of oral sulpiride formulations were calculated from plasma concentration-time data obtained in an open, 3-period study with a crossover of the 2 oral formulations in 12 healthy volunteers following single intravenous (100 mg) and oral (2 x 50 mg capsules, 200 mg tablets) application of sulpiride. A model based on 2 Weibull-functions, and applied using NONMEM, described the complex absorption profiles more satisfactorily than a first order absorption model or a model based on a single Weibull-function.
Rietbrock
S
S
Department of Clinical Pharmacology, University Hospital Frankfurt, Germany.
Merz
P G
PG
Fuhr
U
U
Harder
S
S
Marschner
J P
JP
Loew
D
D
Biehl
J
J
D000042:Absorption; D000284:Administration, Oral; D000328:Adult; D001682:Biological Availability; D002214:Capsules; D002851:Chromatography, High Pressure Liquid; D003198:Computer Simulation; D018592:Cross-Over Studies; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008956:Models, Chemical; D012015:Reference Standards; D013469:Sulpiride / Q000008:administration & dosage / Q000097:blood / Q000493:pharmacokinetics*; D013607:Tablets
D002214:Capsules; D013607:Tablets; D013469:Sulpiride