title: Synthesis and antimicrobial evaluation of 4-phenyl-3-isoquinolinoyl-hydrazones.
abstract: 2-Methyl-1-oxo-1,2-dihydro-3-carbazoyl-4-phenylisoquinoline 2, 1-methoxy-7 and 1-chloro-3-carbazoyl-4-phenylisoquinoline 12 as well as a series of their 2-hydrazono-derivatives 3 a-i, 8 a-i and 14 a-i were synthesized and evaluated for their antibacterial and antifungal activities, in vitro. Compound 3 h was fairly active against Staphylococcus aureus, Staphylococcus epidermidis and streptococci group B.
authors.affiliation: Istituto di Chimica Farmaceutica e Tossicologica, Università di Catania, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Vittorio
authors.forename: G
authors.initials: G
authors.lastname: Ronsisvalle
authors.forename: A
authors.initials: A
authors.lastname: Marrazzo
authors.forename: G
authors.initials: G
authors.lastname: Blandino
mesh_terms: D000900:Anti-Bacterial Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D006090:Gram-Negative Bacteria / Q000187:drug effects; D006094:Gram-Positive Bacteria / Q000187:drug effects; D006835:Hydrazones / Q000138:chemical synthesis* / Q000494:pharmacology; D007546:Isoquinolines / Q000138:chemical synthesis* / Q000494:pharmacology; D015394:Molecular Structure
chemical_list: D000900:Anti-Bacterial Agents; D006835:Hydrazones; D007546:Isoquinolines