Screening for in vitro anti-tumor promoting activities of edible plants from Thailand.
A total of 112 species of edible plants (122 samples) from Thailand were randomly collected, and their methanol extracts were screened for in vitro anti-tumor promoting activity using the inhibition test of Epstein-Barr virus (EBV) activation in Raji cells induced by 12-O-hexadecanoylphorbol-13-acetate (HPA, 40 ng/ml). It was found that 60% of these extracts inhibited EBV activation by 30% or more at a concentration of 200 mg/ml. Significantly, the ratio is markedly higher than that (26%) previously observed in common edible plants in Japan. Thus, physiological potentiality of edible Thai plants has been implied in terms of cancer chemoprevention.
Murakami
A
A
Department of Food Science and Technology, Faculty of Agriculture, Kyoto University, Japan.
Jiwajinda
S
S
Koshimizu
K
K
Ohigashi
H
H
D016588:Anticarcinogenic Agents / Q000737:chemistry*; D004854:Herpesvirus 4, Human; D006801:Humans; D066298:In Vitro Techniques; D009152:Mutagenicity Tests; D010945:Plants, Edible / Q000737:chemistry*; D010946:Plants, Medicinal / Q000737:chemistry*; D013785:Thailand; D014779:Virus Replication / Q000187:drug effects
D016588:Anticarcinogenic Agents