title: Synthesis of 3'-O-(2-aminoethyl)-2'-deoxyuridines.
abstract: Methyl 2-deoxy-3-O-[2-(formylamino)ethyl]-5-O-trityl-D-erythro- pentofuranoside (4) was obtained in a 3-O alkylation reaction by treatment with 2-chloroethylamine in DMF. Compound 4 afforded alpha nucleosides as the main products when condensed with uracils under the Vorbrüggen conditions. The nucleosides were deblocked by treatment with 80% acetic acid and subsequently with sodium methoxide in methanol.
authors.affiliation: Department of Chemistry, Odense University, Denmark.
authors.forename: A A
authors.initials: AA
authors.lastname: Abdel Aleem
authors.forename: E
authors.initials: E
authors.lastname: Larsen
authors.forename: E B
authors.initials: EB
authors.lastname: Pedersen
authors.forename: C
authors.initials: C
authors.lastname: Nielsen
mesh_terms: D000818:Animals; D000998:Antiviral Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D002470:Cell Survival / Q000187:drug effects; D002478:Cells, Cultured; D002522:Chlorocebus aethiops; D003857:Deoxyuridine / Q000031:analogs & derivatives* / Q000138:chemical synthesis* / Q000494:pharmacology; D015497:HIV-1 / Q000187:drug effects; D000882:Haplorhini; D014709:Vero Cells / Q000187:drug effects
chemical_list: D000998:Antiviral Agents; D003857:Deoxyuridine