title: Substituted thiazolidinediones and thio-imidazolidinones: synthesis, structural study and pharmacological activity.
abstract: Synthesis and physico-chemical properties of six 3-(4-bromophenacyl)-5-arylidene-thiazolidine-2,4-diones and eight 3-(4-chlorobenzyl)-5-arylidene-4-thio-imidazolidine-2-ones are described. These products were synthesized by an aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted thiazolidine-2,4-diones or 4-thio-imidazolidine-2-ones. Hypoglycemic and peripheral antinociceptive activities were investigated for these compounds.
authors.affiliation: Departamento de Antibiotics, Universidade Federal de Pernambuco, Recife, Brésil.
authors.forename: J F
authors.initials: JF
authors.lastname: Albuquerque
authors.forename: A
authors.initials: A
authors.lastname: Albuquerque
authors.forename: C C
authors.initials: CC
authors.lastname: Azevedo
authors.forename: F
authors.initials: F
authors.lastname: Thomasson
authors.forename: L S
authors.initials: LS
authors.lastname: Galdino
authors.forename: J
authors.initials: J
authors.lastname: Chantegrel
authors.forename: M T
authors.initials: MT
authors.lastname: Catanho
authors.forename: I R
authors.initials: IR
authors.lastname: Pitta
authors.forename: C
authors.initials: C
authors.lastname: Luu-Duc
mesh_terms: D000478:Alkylation; D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
chemical_list: D000700:Analgesics; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007093:Imidazoles; D013844:Thiazoles