[Prescription of non-steroidal anti-inflammatory agents and risk of iatrogenic adverse effects: a survey of 1072 French general practitioners].
As a group, non-steroidal anti-inflammatory drugs (NSAIDs) rank first among commonly prescribed drugs for serious adverse reactions. We conducted a cross-sectional survey in which 1072 French general practitioners (GPs) were evaluated for their basic pharmacological knowledge and practice of NSAIDs prescription. Results suggest that GPs have insufficient pharmacological knowledge and provide inadequate management of adverse reaction risk. Well-established risk factors for serious adverse reactions, such as age, are not taken enough into account, and tolerance is not correctly monitored. Drugs allegedly protecting against peptic ulcers are frequently associated but, most of the time, without any relevant justification, such as the patient's risk level or drug's efficacy. Our findings demonstrate a need for greater information among GPs about prescription and tolerance monitoring of NSAIDs.
Coste
J
J
Département de Biostatistique et d'Informatique Médicale, Hôpital Cochin, Paris, France.
Hanotin
C
C
Leutenegger
E
E
D000328:Adult; D000894:Anti-Inflammatory Agents, Non-Steroidal / Q000009:adverse effects* / Q000627:therapeutic use; D011307:Drug Prescriptions / Q000706:statistics & numerical data*; D005602:France / Q000453:epidemiology; D006801:Humans; D007049:Iatrogenic Disease / Q000517:prevention & control; D010821:Physicians, Family / Q000706:statistics & numerical data; D012307:Risk Factors
D000894:Anti-Inflammatory Agents, Non-Steroidal
Prescription des anti-inflammatoires non stéroïdiens et pratiques à risque de iatrogènie: étude chez 1072 médecins généralistes français.