title: Comparison of ondansetron and droperidol in the prevention of nausea and vomiting after inpatient minor gynecologic surgery.
abstract: Ondansetron and droperidol are both effective in the prevention of postoperative nausea and vomiting (PONV). In this randomized, double-blind study, 80 inpatients scheduled for minor gynecologic surgery received either ondansetron 8 mg intravenously (i.v.) or droperidol 2.5 mg i.v. 5 min prior to induction of isoflurane-narcotic anesthesia. PONV was absent in 68% of the patients after ondansetron and in 88% after droperidol (P < 0.05). The respective times of complete arousal from anesthesia were 171 min and 229 min (P < 0.001). After ondansetron and droperidol, the incidence of severe drowsiness, restlessness, anxiety, or dizziness was 5% and 28%, respectively (P < 0.01). Thus after minor gynecologic surgery, droperidol 2.5 mg i.v. was superior to ondansetron 8 mg i.v. in the prevention of PONV. However, relative to ondansetron, droperidol entailed an average 1-h delay in recovery from anesthesia.
authors.affiliation: Department of Anesthesiology and Operative Intensive Care, University of Cologne, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Grond
authors.forename: J
authors.initials: J
authors.lastname: Lynch
authors.forename: C
authors.initials: C
authors.lastname: Diefenbach
authors.forename: K
authors.initials: K
authors.lastname: Altrock
authors.forename: K A
authors.initials: KA
authors.lastname: Lehmann
mesh_terms: D000328:Adult; D000758:Anesthesia / Q000009:adverse effects; D004311:Double-Blind Method; D004329:Droperidol / Q000627:therapeutic use*; D005260:Female; D005836:Genitalia, Female / Q000601:surgery*; D006801:Humans; D007530:Isoflurane; D008875:Middle Aged; D009325:Nausea / Q000209:etiology / Q000517:prevention & control*; D017294:Ondansetron / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control*; D011446:Prospective Studies; D014839:Vomiting / Q000209:etiology / Q000517:prevention & control*
chemical_list: D017294:Ondansetron; D007530:Isoflurane; D004329:Droperidol