Efficacy of a temperature-sensitive Sendai virus vaccine in hamsters.
A temperature-sensitive HVJ-pB strain of parainfluenza type 1 (Sendai) virus was obtained from a persistently virus-infected cell culture. Intranasal inoculation of Syrian hamsters with the HVJ-pB temperature-sensitive mutant resulted in an abortive infection but induced a specific antibody response against Sendai virus without appreciable lesions in the respiratory tract. Prior exposure to the temperature-sensitive mutant protected hamsters from subsequent challenge with virulent wild-type virus. The efficacy of protection became apparent at 5 days after vaccination and lasted for at least 720 days. For practical use of the HVJ-pB vaccine, a single intranasal administration to newborn babies aged over 15 days is recommended.
Tagaya
M
M
Department of Microbiology, Fukui Medical School, Japan.
Mori
I
I
Miyadai
T
T
Kimura
Y
Y
Ito
H
H
Nakakuki
K
K
D000281:Administration, Intranasal; D000818:Animals; D000831:Animals, Newborn; D000914:Antibodies, Viral / Q000096:biosynthesis*; D006224:Cricetinae; D005260:Female; D006801:Humans; D008168:Lung / Q000473:pathology / Q000821:virology; D008297:Male; D008647:Mesocricetus; D009154:Mutation; D010222:Parainfluenza Virus 1, Human / Q000235:genetics / Q000254:growth & development / Q000276:immunology*; D018184:Paramyxoviridae Infections / Q000517:prevention & control / Q000662:veterinary*; D012140:Respiratory Tract Diseases / Q000517:prevention & control / Q000662:veterinary; D012376:Rodent Diseases / Q000517:prevention & control*; D013696:Temperature; D014611:Vaccination / Q000662:veterinary; D014613:Vaccines, Attenuated / Q000276:immunology; D014765:Viral Vaccines / Q000008:administration & dosage / Q000276:immunology*; D014779:Virus Replication
D000914:Antibodies, Viral; D014613:Vaccines, Attenuated; D014765:Viral Vaccines