Food palatability and hunger modulated effects of CGS 9896 and CGS 8216 on food intake.
The effect of food palatability and duration of food deprivation on the modulation of food intake by two benzodiazepine receptor (BDZR) ligands, CGS 9896 and CGS 8216, were investigated. Three diets differing in palatability (high, medium, or standard) and three different periods of food deprivation (0, 16, or 24 h) were used in all combinations to compare the effect of these variations on the observed modulation of food consumption by both BDZR ligands. Increasing diet palatability and/or food deprivation increased the baseline food consumption and reduced the sensitivity of the test to the detection of the hyperphagic effect of CGS 9896 but increased the sensitivity to detect the anorexic effect of CGS 8216. Only for the intermediate conditions of food deprivation (16 h) and for a standard or medium palatable diet were both significant hyperphagic effect of CGS 9896 and anorexic effect of CGS 8216 detected. Neither increased palatability nor hunger enhanced the modulation of feeding, indicating that neither "taste preference" nor "hunger" is the key factor in the mechanism of BDZR ligand-induced feeding response.
Chen
S W
SW
Molecular Research Institute, Palo Alto, CA 94304, USA.
Davies
M F
MF
Loew
G H
GH
D000818:Animals; D004032:Diet; D004305:Dose-Response Relationship, Drug; D004435:Eating / Q000187:drug effects*; D005502:Food; D018756:GABA Antagonists / Q000494:pharmacology*; D006815:Hunger / Q000187:drug effects*; D008297:Male; D011720:Pyrazoles / Q000494:pharmacology*; D051381:Rats; D013649:Taste / Q000187:drug effects*
D018756:GABA Antagonists; D011720:Pyrazoles; C034704:2-(4-chlorophenyl)-2,5-dihydropyrazolo(4,3-c)quinoline-3(3H)-one; C033830:2-phenylpyrazolo(4,3-c)quinolin-3(5H)-one