Neuroprotection in vitro and in vivo by cell membrane-permeant Ca2+ chelators.
1. A method of attenuating excitotoxic and hypoxic/ischaemic neurodegeneration in vitro and in vivo using cell-permeant Ca(2+)-chelating agents is described. 2. The mechanism of neuroprotection may depend on both pre- and post-synaptic effects on intracellular Ca2+ dynamics. 3. This method is unique, because it targets Ca2+ ions, the presumed triggers of neurodegeneration, rather than a specific cellular receptor.
Tymianski
M
M
Playfair Neuroscience Unit, University of Toronto, Ontario, Canada.
D000818:Animals; D002545:Brain Ischemia / Q000503:physiopathology / Q000517:prevention & control; D002118:Calcium / Q000378:metabolism*; D002463:Cell Membrane Permeability / Q000187:drug effects; D002478:Cells, Cultured; D002614:Chelating Agents / Q000494:pharmacology* / Q000627:therapeutic use; D004533:Egtazic Acid / Q000031:analogs & derivatives / Q000494:pharmacology / Q000627:therapeutic use; D018698:Glutamic Acid / Q000633:toxicity; D007202:Indicators and Reagents / Q000494:pharmacology; D009474:Neurons / Q000166:cytology / Q000187:drug effects*; D009498:Neurotoxins / Q000633:toxicity; D051381:Rats; D009435:Synaptic Transmission / Q000187:drug effects*
D002614:Chelating Agents; D007202:Indicators and Reagents; D009498:Neurotoxins; D018698:Glutamic Acid; D004533:Egtazic Acid; C025603:1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid; D002118:Calcium