Cytogenetic effect of malathion in in vitro culture of human peripheral blood.
Chromosomal aberrations, sister-chromatid exchanges and mitotic indices were observed in human peripheral leukocytes, treated with four different concentrations of malathion (0.02, 0.2, 2 and 20 micrograms/ml), an organophosphate pesticide, added to the culture medium at 0, 24 and 48 h after culture initiation. These cultures showed a dose-dependent increase in the frequency of chromosomal aberration as well as sister-chromatid exchanges. There was a significant decrease in mitotic index at all concentrations.
Balaji
M
M
Department of Zoology, Bharathiar University, Coimbatore, India.
Sasikala
K
K
D000328:Adult; D002478:Cells, Cultured; D002869:Chromosome Aberrations; D004305:Dose-Response Relationship, Drug; D006801:Humans; D007962:Leukocytes / Q000187:drug effects*; D008294:Malathion / Q000008:administration & dosage / Q000633:toxicity*; D008297:Male; D008938:Mitosis / Q000187:drug effects; D008940:Mitotic Index; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D012854:Sister Chromatid Exchange
D009153:Mutagens; D008294:Malathion