title: Treatment of Helicobacter pylori infection with a combination of itraconazole and omeprazole.
abstract: OBJECTIVE
  To determine the in vivo anti-microbial activity of a high-dose itraconazole and omeprazole regimen against Helicobacter pylori.
  
  
  METHODS
  In an open pilot study, 10 H. pylori positive dyspeptic patients were treated with itraconazole 200 mg b.d. and omeprazole 200 mg b.d. for 7 days. Follow-up upper gastrointestinal endoscopy was performed 4-5 weeks after completion of therapy. Eradication of H. pylori infection was determined by histopathological examination and culture of biopsies from the antrum and corpus.
  
  
  RESULTS
  Eradication was not observed in any patient.
  
  
  CONCLUSIONS
  This combination of itraconazole with omeprazole does not eradicate H. pylori infection.
authors.affiliation: Department of Gastroenterology and Hepatology, Academic Medical Centre, Amsterdam, The Netherlands.
authors.forename: I J
authors.initials: IJ
authors.lastname: Keller
authors.forename: R W
authors.initials: RW
authors.lastname: van der Hulst
authors.forename: G N
authors.initials: GN
authors.lastname: Tytgat
mesh_terms: D000328:Adult; D000368:Aged; D004359:Drug Therapy, Combination; D005260:Female; D016481:Helicobacter Infections / Q000188:drug therapy*; D016480:Helicobacter pylori; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D008297:Male; D008875:Middle Aged; D009853:Omeprazole / Q000008:administration & dosage*; D010865:Pilot Projects
chemical_list: D017964:Itraconazole; D009853:Omeprazole