Deliberate overdose with the novel anticonvulsant tiagabine.
Tiagabine is a novel antiepileptic drug which acts by decreasing gamma aminobutyric acid uptake in astrocytes and neurones. Here the first case of deliberate overdose with this compound in a patient on concomitant phenytoin is reported. On admission to hospital his conscious level deteriorated to grade III coma. No changes in the electrocardiogram were noted. Recovery from the initial effects was rapid, and there were no sequelae. Plasma levels of tiagabine (3.1 micrograms/ml) 4 hours after ingestion were 30 times higher than at typical steady state during therapeutic dosing. The effects of poisoning with current first-line antiepileptic drugs are reviewed. The newer agents, particularly those with greater biochemical specificity, may be safer in overdose than the more established anticonvulsants.
Leach
J P
JP
University Department of Medicine and Therapeutics, Western Infirmary, Glasgow, Scotland, UK.
Stolarek
I
I
Brodie
M J
MJ
D000328:Adult; D000927:Anticonvulsants / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D004359:Drug Therapy, Combination; D017029:Epilepsy, Complex Partial / Q000097:blood / Q000188:drug therapy*; D006801:Humans; D008297:Male; D008657:Metabolic Clearance Rate / Q000502:physiology; D009557:Nipecotic Acids / Q000008:administration & dosage / Q000493:pharmacokinetics / Q000506:poisoning*; D010672:Phenytoin / Q000008:administration & dosage / Q000493:pharmacokinetics; D000078308:Tiagabine
D000927:Anticonvulsants; D009557:Nipecotic Acids; D010672:Phenytoin; D000078308:Tiagabine