title: Indices from flow-volume curves in relation to cephalometric, ENT- and sleep-O2 saturation variables in snorers with and without obstructive sleep-apnoea.
abstract: In a group of 37 heavy snorers with obstructive sleep apnoea (OSA, Group 1) and a group of 23 heavy snorers without OSA (Group 2) cephalometric indices, ENT indices related to upper airway collapsibility, and nocturnal O2 desaturation indices were related to variables from maximal expiratory and inspiratory flow-volume (MEFV and MIFV) curves. The cephalometric indices used were the length and diameter of the soft palate (spl and spd), the shortest distance between the mandibular plane and the hyoid bone (mph) and the posterior airway space (pas). Collapsibility of the upper airways was observed at the level of the tongue base and soft palate by fibroscopy during a Müller manoeuvre (mtb and msp) and ranked on a five point scale. Sleep indices measured were the mean number of oxygen desaturations of more than 3% per hour preceded by an apnoea or hypopnoea of more than 10 s (desaturation index), maximal sleep oxygen desaturation, baseline arterial oxygen saturation (Sa,O2) and, in the OSA group, percentage of sleep time with Sa,O2 < 90%. The variables obtained from the flow-volume curves were the forced vital capacity (FVC), forced expiratory and inspiratory volume in 1 s (FEV1 and FIV1), peak expiratory and peak inspiratory flows (PEF and PIF), and maximal flow after expiring 50% of the FVC (MEF50). The mean of the flow-volume variables, influenced by upper airway aperture (PEF, FIV1) was significantly greater than predicted.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Dept of Pulmonary Diseases, University Hospital Dijkzigt, Erasmus University, Rotterdam, The Netherlands.
authors.forename: J M
authors.initials: JM
authors.lastname: Bogaard
authors.forename: F G
authors.initials: FG
authors.lastname: van der Meché
authors.forename: R M
authors.initials: RM
authors.lastname: Poublon
authors.forename: A Z
authors.initials: AZ
authors.lastname: Ginai
authors.forename: P I
authors.initials: PI
authors.lastname: Schmitz
authors.forename: A
authors.initials: A
authors.lastname: Bubberman
authors.forename: A M
authors.initials: AM
authors.lastname: Slappendel
authors.forename: H
authors.initials: H
authors.lastname: Boot
mesh_terms: D000403:Airway Resistance / Q000502:physiology; D016022:Case-Control Studies; D002508:Cephalometry; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D010100:Oxygen / Q000097:blood; D017286:Polysomnography; D012123:Pulmonary Ventilation / Q000502:physiology*; D012891:Sleep Apnea Syndromes / Q000175:diagnosis / Q000503:physiopathology*; D012913:Snoring / Q000175:diagnosis / Q000503:physiopathology*
chemical_list: D010100:Oxygen