title: Effect of novel aromatic derivative of GABA on lipid peroxidation in chronically morphinized rats.
abstract: Effect of novel aromatic GABA derivative (AFA) on lipid peroxidation (LP) was studied in the male rats of the Wistar strain. The morphine-received animals had the higher level of LP in blood plasma, decreased level of total antioxidant activity, the increased rate of LP in the ascorbate-induced system in liver homogenate. In the case of AFA administration with morphine, all the above mentioned effects were almost withdrawn.
authors.affiliation: M.V. Lomonosov Institute of Fine Chemical Technology, Moscow 117571, Russia.
authors.forename: E
authors.initials: E
authors.lastname: Lurie
authors.forename: A
authors.initials: A
authors.lastname: Soloviova
authors.forename: T
authors.initials: T
authors.lastname: Alyabieva
authors.forename: A
authors.initials: A
authors.lastname: Kaplun
authors.forename: L
authors.initials: L
authors.lastname: Panchenko
authors.forename: V
authors.initials: V
authors.lastname: Shvets
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology; D010636:Phenols / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
chemical_list: D000975:Antioxidants; D010636:Phenols; D005680:gamma-Aminobutyric Acid; D009020:Morphine; D001205:Ascorbic Acid