Inhibition of CTP synthetase induces differentiation of HL-60 cells and down-regulation of the c-myc oncogene.
Van Kuilenburg
A B
AB
University of Amsterdam, Department of Pediatrics, The Netherlands.
Van den Berg
A A
AA
Meinsma
J R
JR
Slingerland
R J
RJ
Van Gennip
A H
AH
D015092:3-Deazauridine / Q000494:pharmacology*; D015152:Blotting, Northern; D019731:Carbon-Nitrogen Ligases; D002454:Cell Differentiation / Q000187:drug effects*; D002460:Cell Line; D004121:Dimethyl Sulfoxide / Q000494:pharmacology*; D015972:Gene Expression Regulation, Neoplastic / Q000187:drug effects*; D016259:Genes, myc / Q000187:drug effects*; D006801:Humans; D015473:Leukemia, Promyelocytic, Acute; D008025:Ligases / Q000037:antagonists & inhibitors*; D014407:Tumor Cells, Cultured
D015092:3-Deazauridine; D008025:Ligases; D019731:Carbon-Nitrogen Ligases; C019951:CTP synthetase; D004121:Dimethyl Sulfoxide