Amphotericin B followed by itraconazole in the treatment of disseminated fungal infections in neutropenic patients.
The role of the new triazoles in the treatment of disseminated fungal infections in neutropenic patients is at present under scrutiny. Six neutropenic patients with disseminated fungal infections were treated with amphotericin B during neutropenia and itraconazole after bone marrow recovery. There were three pulmonary aspergillomas, one Aspergillus fumigatus sinusitis, one Fusarium-mycosis and one disseminated candidosis. Four patients were cured of the infection. This approach seems to be safe and effective in the treatment of disseminated fungal infections in neutropenic patients, with the advantages of low side-effects and the possibility of early discharge from hospital.
Nucci
M
M
Hematology Service, University Hospital, Federal University of Rio de Janeiro, Brazil.
Pulcheri
W
W
Bacha
P C
PC
Spector
N
N
Caiuby
M J
MJ
Costa
R O
RO
de Oliveira
H P
HP
D000328:Adult; D000666:Amphotericin B / Q000008:administration & dosage*; D002648:Child; D005260:Female; D006801:Humans; D017964:Itraconazole / Q000008:administration & dosage*; D007938:Leukemia / Q000150:complications; D008297:Male; D009181:Mycoses / Q000188:drug therapy* / Q000209:etiology; D009503:Neutropenia / Q000150:complications
D017964:Itraconazole; D000666:Amphotericin B