title: Association between renal tubular cell dysfunction and increased urinary zinc excretion in cancer patients.
abstract: Although an increase in renal zinc excretion in cancer patients is well documented, the mechanisms involved are still disputed. As recent studies have raised the question of the role of renal tubular cell dysfunction in the elevation of urinary zinc output, we have examined urinary zinc excretion and the excretion of N-acetyl-beta-D-glucosaminidase (NAG), an indicator of tubular cell dysfunction, in 30 patients with cancer, 28 healthy controls and 20 patients with benign non-inflammatory disorders. As expected, urinary zinc excretion was significantly higher in the cancer patients compared with controls and patients with benign disorders (2.64 +/- 3.05 vs. 0.86 +/- 0.36 and 0.89 +/- 0.29 mmol mol creatinine-1, p < 0.001). NAG activity was also elevated (18.9 +/- 20.1 vs. 4.32 +/- 3.33 and 9.99 +/- 9.72 mukat mol creatinine-1, p < 0.001 and p < 0.05, respectively). A significant correlation between urine zinc and NAG was observed in all three groups (rho = 0.73, p < 0.001, rho = 0.55, p < 0.01 and rho = 0.45, p < 0.05, respectively). In conclusion, our data provide additional support for the role of renal tubular cell dysfunction in hyperzincuria in cancer. Urinary zinc measurement may represent an alternative approach to detecting renal tubular dysfunction in human pathology.
authors.affiliation: Second Department of Internal Medicine, Charles University Medical School, Hradec Králové, Czech Republic.
authors.forename: B
authors.initials: B
authors.lastname: Melichar
authors.forename: P
authors.initials: P
authors.lastname: Jandík
authors.forename: F
authors.initials: F
authors.lastname: Malír
authors.forename: J
authors.initials: J
authors.lastname: Vávrová
authors.forename: J
authors.initials: J
authors.lastname: Bures
authors.forename: J
authors.initials: J
authors.lastname: Mergancová
authors.forename: Z
authors.initials: Z
authors.lastname: Voboril
mesh_terms: D000118:Acetylglucosaminidase / Q000378:metabolism; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007684:Kidney Tubules / Q000201:enzymology / Q000473:pathology / Q000503:physiopathology*; D008297:Male; D008875:Middle Aged; D009369:Neoplasms / Q000473:pathology / Q000652:urine*; D011237:Predictive Value of Tests; D015032:Zinc / Q000652:urine*
chemical_list: D000118:Acetylglucosaminidase; D015032:Zinc