Chorionic villus sampling followed by amniocentesis in the same pregnancy.
In our consecutive series of 2,574 chorionic villus sampling (CVS) patients, 146 women (5.7%) underwent a subsequent amniocentesis in the same pregnancy for the indications of absent or insufficient villi (3.3%), elevated maternal serum alpha-fetoprotein (0.93%), CVS mosaicism (0.89%), culture failure (0.23%), specimen contamination (0.15%), and CVS aneuploidy (0.12%). Patients presenting for a CVS should be informed of the possible need for a subsequent amniocentesis in the same pregnancy. There is a need for individual prenatal diagnosis programs to analyze their own data and provide genetic counseling information which pertains specifically to their institution.
Donnenfeld
A E
AE
Department of Obstetrics and Gynecology, Pennsylvania Hospital, Philadelphia 19107.
Librizzi
R J
RJ
Dunn
L K
LK
Craparo
F
F
Godmilow
L
L
Weiner
S
S
D000649:Amniocentesis / Q000009:adverse effects / Q000706:statistics & numerical data; D015193:Chorionic Villi Sampling / Q000009:adverse effects; D005260:Female; D005313:Fetal Death / Q000209:etiology; D005315:Fetal Diseases / Q000175:diagnosis / Q000235:genetics; D005817:Genetic Counseling; D030342:Genetic Diseases, Inborn / Q000175:diagnosis; D006801:Humans; D009030:Mosaicism; D011247:Pregnancy; D011248:Pregnancy Complications / Q000097:blood; D000509:alpha-Fetoproteins / Q000032:analysis
D000509:alpha-Fetoproteins