title: Effect of maternal rotavirus immunization on milk and serum antibody titers.
abstract: This prospective study evaluated human milk and serum antirotavirus antibody concentrations following maternal rotavirus immunization. Postpartum women (33) were randomized into 3 groups and received a single oral dose of rhesus rotavirus monovalent reassortant vaccine (10(4) pfu), tetravalent vaccine (10(4) pfu), or placebo. Milk (secretory [s] IgA) and serum (IgA and IgG) specimens were tested for antirotavirus isotype-specific antibody. Sera also were tested for G1- to G4-specific antibody. Prevaccine milk and serum isotype-specific antibody concentrations were not significantly different in the 3 groups. Postvaccine sIgA log titers were significantly greater in the 2 vaccine groups than the placebo group (P = .002). Mean log10 titers at 1 week were 2.1 (95% confidence interval [CI], 2.0-2.3) in the 2 vaccine groups and 1.7 (95% CI, 1.5-1.9) in the placebo group. Milk titers did not differ between vaccine groups. There was no difference in reactogenicity between groups. The significantly higher milk concentrations of antibody to rotavirus in postpartum women who received rotavirus immunization persisted for 4 months.
authors.affiliation: Center for Pediatric Research, Children's Hospital of the King's Daughters, Eastern Virginia Medical School, Norfolk, USA.
authors.forename: L K
authors.initials: LK
authors.lastname: Pickering
authors.forename: A L
authors.initials: AL
authors.lastname: Morrow
authors.forename: I
authors.initials: I
authors.lastname: Herrera
authors.forename: M
authors.initials: M
authors.lastname: O'Ryan
authors.forename: M K
authors.initials: MK
authors.lastname: Estes
authors.forename: S E
authors.initials: SE
authors.lastname: Guilliams
authors.forename: L
authors.initials: L
authors.lastname: Jackson
authors.forename: S
authors.initials: S
authors.lastname: Carter-Campbell
authors.forename: D O
authors.initials: DO
authors.lastname: Matson
mesh_terms: D000293:Adolescent; D000328:Adult; D000914:Antibodies, Viral / Q000032:analysis* / Q000097:blood; D001942:Breast Feeding; D005260:Female; D006801:Humans; D007114:Immunization; D007070:Immunoglobulin A / Q000032:analysis / Q000097:blood; D007071:Immunoglobulin A, Secretory / Q000032:analysis / Q000097:blood; D007074:Immunoglobulin G / Q000032:analysis / Q000097:blood; D008895:Milk, Human / Q000276:immunology*; D049590:Postpartum Period / Q000276:immunology; D011247:Pregnancy; D011251:Pregnancy Complications, Infectious / Q000276:immunology* / Q000517:prevention & control; D011446:Prospective Studies; D012401:Rotavirus / Q000276:immunology*; D012400:Rotavirus Infections / Q000276:immunology* / Q000517:prevention & control; D014765:Viral Vaccines
chemical_list: D000914:Antibodies, Viral; D007070:Immunoglobulin A; D007071:Immunoglobulin A, Secretory; D007074:Immunoglobulin G; D014765:Viral Vaccines