4-Aza-3-oxo-5 alpha-androst-1-ene-17 beta-N-aryl-carboxamides as dual inhibitors of human type 1 and type 2 steroid 5 alpha-reductases. Dramatic effect of N-aryl substituents on type 1 and type 2 5 alpha-reductase inhibitory potency.
Bakshi
R K
RK
Department of Medicinal Chemical Research, Molecular Systems, and Biochemistry, Merck Research Laboratories, Rahway, New Jersey 07065, USA.
Rasmusson
G H
GH
Patel
G F
GF
Mosley
R T
RT
Chang
B
B
Ellsworth
K
K
Harris
G S
GS
Tolman
R L
RL
D058891:5-alpha Reductase Inhibitors; D000736:Androstenes / Q000737:chemistry / Q000494:pharmacology*; D001378:Azasteroids / Q000737:chemistry / Q000494:pharmacology*; D006801:Humans; D008968:Molecular Conformation; D013816:Thermodynamics
D058891:5-alpha Reductase Inhibitors; D000736:Androstenes; D001378:Azasteroids