Inhibitory effect of xian-qing-long-tan extract on degranulation and histamine release from rat mast cells.
Xian-Qing-Long-Tang (XQLT), a Chinese medicine, is useful for treating allergic diseases. To demonstrate the anti-allergic effect of this drug we examined its effect on degranulation and histamine release from rat mast cells induced by antigen and compound 48/80. The effect on 48 h homologous passive cutaneous anaphylaxis (PCA) in rats was also studied. In the IgE antigen-antibody reaction using DNP-As, XQLT inhibited histamine release from rat mast cells, in vitro; it also inhibited 48 h rat homologous PCA reaction, in vivo. These results suggest that XQLT inhibits type 1 allergic reaction, and has effectiveness for allergic disease.
Matsumoto
T
T
Department of Otorhinolaryngology, Osaka Prefectural Hospital, Japan.
Ishida
M
M
Makino
M
M
Shibata
T
T
Ogino
S
S
Matsunaga
T
T
D000818:Animals; D000942:Antigens, Bacterial / Q000008:administration & dosage; D000947:Antigens, Helminth / Q000008:administration & dosage; D001200:Ascaris / Q000276:immunology; D001886:Bordetella pertussis / Q000276:immunology; D015550:Cell Degranulation / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000008:administration & dosage / Q000494:pharmacology*; D006636:Histamine Release / Q000187:drug effects*; D007114:Immunization; D008297:Male; D008407:Mast Cells / Q000187:drug effects* / Q000276:immunology; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats; D017208:Rats, Wistar; D003189:p-Methoxy-N-methylphenethylamine / Q000494:pharmacology
D000942:Antigens, Bacterial; D000947:Antigens, Helminth; D004365:Drugs, Chinese Herbal; D003189:p-Methoxy-N-methylphenethylamine