Effect of novel aromatic derivative of GABA on lipid peroxidation in chronically morphinized rats.
Effect of novel aromatic GABA derivative (AFA) on lipid peroxidation (LP) was studied in the male rats of the Wistar strain. The morphine-received animals had the higher level of LP in blood plasma, decreased level of total antioxidant activity, the increased rate of LP in the ascorbate-induced system in liver homogenate. In the case of AFA administration with morphine, all the above mentioned effects were almost withdrawn.
Lurie
E
E
M.V. Lomonosov Institute of Fine Chemical Technology, Moscow 117571, Russia.
Soloviova
A
A
Alyabieva
T
T
Kaplun
A
A
Panchenko
L
L
Shvets
V
V
D000818:Animals; D000975:Antioxidants / Q000378:metabolism; D001205:Ascorbic Acid / Q000097:blood / Q000494:pharmacology; D015227:Lipid Peroxidation / Q000187:drug effects*; D008099:Liver / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D009020:Morphine / Q000008:administration & dosage / Q000494:pharmacology; D010636:Phenols / Q000378:metabolism / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D005680:gamma-Aminobutyric Acid / Q000031:analogs & derivatives* / Q000494:pharmacology*
D000975:Antioxidants; D010636:Phenols; D005680:gamma-Aminobutyric Acid; D009020:Morphine; D001205:Ascorbic Acid