The role of histamine H1-receptors in the modulation of neurotransmitter receptors activity in human lung cancer.
An abnormality in autonomic neural control in lung cancer has not yet been investigated. In the present work the role of histamine H1-receptors in the modulation of neurotransmitter receptors activity in human lung parenchyma in cancer is reported. It appeared that the activation of histamine H1-receptors may lead to the reduction of beta-adrenoceptors and the enhancement of muscarinic cholinergic receptors in cancer lung parenchyma. The above findings suggest the possibility of the interaction between neural and inflammatory systems in human lung cancer.
Kondratenko
T Y
TY
Research Center of Molecular Diagnostic and Therapy, Moscow, Russia.
Zacharova
I V
IV
Kuzina
N V
NV
Katukov VYu
Severin
E S
ES
D000109:Acetylcholine / Q000378:metabolism; D000328:Adult; D004082:Dihydroalprenolol / Q000378:metabolism; D006801:Humans; D008175:Lung Neoplasms / Q000378:metabolism*; D008297:Male; D008875:Middle Aged; D011485:Protein Binding; D011738:Pyrilamine / Q000378:metabolism; D011813:Quinuclidinyl Benzilate / Q000378:metabolism; D011941:Receptors, Adrenergic / Q000378:metabolism*; D011969:Receptors, Histamine H1 / Q000378:metabolism*; D011976:Receptors, Muscarinic / Q000378:metabolism*
D011941:Receptors, Adrenergic; D011969:Receptors, Histamine H1; D011976:Receptors, Muscarinic; D004082:Dihydroalprenolol; D011813:Quinuclidinyl Benzilate; D011738:Pyrilamine; D000109:Acetylcholine