title: EEG delta, positron emission tomography, and memory deficit in Alzheimer's disease.
abstract: Quantitative scalp EEG from 32 channels and the cerebral glucose metabolic rate from the 32 underlying cortical positions as assessed by positron emission tomography (PET) with 18F-2-deoxyglucose (FDG) were obtained on 36 patients with mild to moderate senile dementia of the Alzheimer type and 17 age- and sex-matched normal control subjects. Subjects performed a verbal memory task during uptake of FDG. There were significant correlations between both delta amplitude and metabolic rate and memory performance during FDG uptake. Patients with Alzheimer's disease had significantly greater left temporal delta amplitude and lower glucose metabolic rates. Both EEG delta in microvolts and metabolic rate had similar diagnostic sensitivity, but PET had fewer false positives among normals. The left amygdala had the highest sensitivity and percent correct diagnosis of any brain area. Temporal lobe EEG delta activity showed higher correlations with hippocampal metabolic rate than metabolic rate directly under the electrode.
authors.affiliation: Fundação Hospitalar do Estado de Minas Gerais, Brazil.
authors.forename: D C
authors.initials: DC
authors.lastname: Valladares-Neto
authors.forename: M S
authors.initials: MS
authors.lastname: Buchsbaum
authors.forename: W J
authors.initials: WJ
authors.lastname: Evans
authors.forename: D
authors.initials: D
authors.lastname: Nguyen
authors.forename: P
authors.initials: P
authors.lastname: Nguyen
authors.forename: B V
authors.initials: BV
authors.lastname: Siegel
authors.forename: J
authors.initials: J
authors.lastname: Stanley
authors.forename: A
authors.initials: A
authors.lastname: Starr
authors.forename: S
authors.initials: S
authors.lastname: Guich
authors.forename: D
authors.initials: D
authors.lastname: Rice
mesh_terms: D000368:Aged; D000544:Alzheimer Disease / Q000503:physiopathology* / Q000523:psychology; D001931:Brain Mapping; D003700:Delta Rhythm; D003847:Deoxyglucose / Q000031:analogs & derivatives; D005260:Female; D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D005947:Glucose / Q000378:metabolism; D006801:Humans; D008297:Male; D008569:Memory Disorders / Q000503:physiopathology* / Q000523:psychology; D011569:Psychiatric Status Rating Scales; D013702:Temporal Lobe / Q000502:physiology; D014055:Tomography, Emission-Computed
chemical_list: D005462:Fluorine Radioisotopes; D019788:Fluorodeoxyglucose F18; D003847:Deoxyglucose; D005947:Glucose