title: [Prognosis of acute myocardial infarction after introduction of thrombolytic therapy].
abstract: The present study describes the use of intravenous thrombolytic therapy, the in-hospital and the long-term mortality in a cohort of 1881 consecutive patients with confirmed myocardial infarction. Thirty-two percent received thrombolytic therapy. Common reasons for not administering thrombolytic therapy were contraindications, diagnostic problems and late hospital admission. The total in-hospital mortality was 14% among patients treated with, and 27% among those treated without thrombolytic therapy (p < 0.001). The mortality among all patients after 48 months of follow-up was 50%. Advanced age, previous myocardial infarction and a higher Killip class on admission were independent predictors of an adverse outcome. In conclusion, in an unselected population with confirmed myocardial infarction the long-term prognosis continues to be dubious, despite the advances in coronary care including intravenous thrombolytic therapy.
authors.affiliation: Medicinsk afdeling B, Rigshospitalet, København.
authors.forename: R
authors.initials: R
authors.lastname: Steffensen
authors.forename: P
authors.initials: P
authors.lastname: Grande
authors.forename: P M
authors.initials: PM
authors.lastname: Clemmensen
authors.forename: E
authors.initials: E
authors.lastname: Sandøe
mesh_terms: D000328:Adult; D000368:Aged; D000075202:Contraindications; D005260:Female; D006801:Humans; D007275:Injections, Intravenous; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000188:drug therapy* / Q000401:mortality; D011379:Prognosis; D013300:Streptokinase / Q000008:administration & dosage*; D015912:Thrombolytic Therapy; D010959:Tissue Plasminogen Activator / Q000008:administration & dosage*
chemical_list: D013300:Streptokinase; D010959:Tissue Plasminogen Activator
vernacular_title: Prognosen ved akut myokardieinfarkt efter introduktion af trombolysebehandling.