Detection of gamma-aminobutyric acid in a living rat brain using in vivo microdialysis-capillary electrophoresis/mass spectrometry.
Coupling of in vivo microdialysis with capillary electrophoresis/mass spectrometry (MD-CE/MS) was demonstrated. A microdialysis probe was inserted in the striatum of a rat brain and gamma-aminobutyric acid (GABA) in the brain was detected by CE/MS without any chemical treatment of the sample. MD-CE/MS is expected to be a useful technique for analyzing brain substances, because of the relatively small damage it causes to a living structure and the high selectivity of the analytical technique.
Takada
Y
Y
Central Research Laboratory, Hitachi Ltd, Tokyo, Japan.
Yoshida
M
M
Sakairi
M
M
Koizumi
H
H
D000818:Animals; D001923:Brain Chemistry; D004586:Electrophoresis; D013058:Mass Spectrometry; D017551:Microdialysis; D051381:Rats; D005680:gamma-Aminobutyric Acid / Q000032:analysis* / Q000378:metabolism
D005680:gamma-Aminobutyric Acid