title: [Synthesis and properties of membrane-addressed antioxidants based on phosphorylated pyrocatechols].
abstract: Amphiphilic membrane-addressed antioxidants differing in their hydrophobic-hydrophilic balance, 3,5-di-tert-butyl-2-hydroxyphenyl phosphate, (3,5-di-tert-butyl-2-hydroxyphenyl)hexadecyl phosphate, and (3,5-di-tert-butyl-2-hydroxyphenyl)-5-cholesten-3 beta-yl phosphate, were synthesized starting from 3,5-di-tert-butyl-o-quinone. Even at 10(-8) M concentration, 3,5-di-tert-butyl-2-hydroxyphenyl phosphate and (3,5-di-tert-butyl-2-hydroxyphenyl)hexadecyl phosphate inhibit formation of malonic aldehyde during peroxidation of lipids from rat brain homogenate initiated with a Fe(2+)-ascorbate system. At 10(-4) M and higher concentrations of antioxidants in the brain homogenate, the formation of malonic aldehyde is inhibited more efficiently than with tocopherol at the same concentrations.
authors.forename: A A
authors.initials: AA
authors.lastname: Akhrem
authors.forename: V I
authors.initials: VI
authors.lastname: Dolgopalets
authors.forename: M A
authors.initials: MA
authors.lastname: Kisel'
authors.forename: N I
authors.initials: NI
authors.lastname: Mezen
authors.forename: V A
authors.initials: VA
authors.lastname: Timoshchuk
authors.forename: A S
authors.initials: AS
authors.lastname: Fedulov
authors.forename: O I
authors.initials: OI
authors.lastname: Shadyro
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000138:chemical synthesis* / Q000378:metabolism; D001921:Brain / Q000378:metabolism; D002396:Catechols / Q000737:chemistry* / Q000378:metabolism; D002462:Cell Membrane / Q000378:metabolism; D015227:Lipid Peroxidation; D009943:Organophosphorus Compounds / Q000138:chemical synthesis* / Q000378:metabolism; D010766:Phosphorylation; D051381:Rats
chemical_list: D000975:Antioxidants; D002396:Catechols; D009943:Organophosphorus Compounds; C034221:catechol
vernacular_title: Sintez i svoĭstva membranoadresovannykh antioksidantov na osnove fosforilirovannykh pirokatekhinov.