title: Apolipoprotein E epsilon 4 allele frequency is not increased in progressive supranuclear palsy.
abstract: We examined apolipoprotein E (ApoE) immunoreactivity and allele frequency in 12 autopsied cases of progressive supranuclear palsy (PSP), a neurodegenerative disease characterized by diffuse neurofibrillary tangle (NFT) formation without beta-amyloid deposits. In spite of the ApoE immunoreactivity associated with NFTs, in PSP the ApoE allele frequency was comparable with that of age-matched normal controls. This suggests that in Alzheimer's disease the increased frequency of ApoE epsilon 4 does not influence neurofibrillary degeneration, but is probably linked to beta-amyloid deposition.
authors.affiliation: Institute of Neurology, University of Genoa, Italy.
authors.forename: M
authors.initials: M
authors.lastname: Tabaton
authors.forename: M
authors.initials: M
authors.lastname: Rolleri
authors.forename: P
authors.initials: P
authors.lastname: Masturzo
authors.forename: S
authors.initials: S
authors.lastname: Cammarata
authors.forename: G
authors.initials: G
authors.lastname: Angelini
authors.forename: L A
authors.initials: LA
authors.lastname: Hansen
authors.forename: T
authors.initials: T
authors.lastname: Saitoh
authors.forename: R B
authors.initials: RB
authors.lastname: Petersen
authors.forename: G
authors.initials: G
authors.lastname: Perry
authors.forename: P
authors.initials: P
authors.lastname: Richey
mesh_terms: D000483:Alleles; D016229:Amyloid beta-Peptides / Q000032:analysis; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D007150:Immunohistochemistry; D016874:Neurofibrillary Tangles / Q000473:pathology; D011149:Pons / Q000473:pathology; D013494:Supranuclear Palsy, Progressive / Q000235:genetics* / Q000473:pathology
chemical_list: D016229:Amyloid beta-Peptides; D053327:Apolipoprotein E4; D001057:Apolipoproteins E