[Onco-gene c-fos expression in light-damaged human embryo retinal pigment epithelium and protective effect of taurine and gamma-interferon].
We used well-cultured human embryo retinal pigment epithelial (RPE) cells to establish a light-damaged RPE cell model. There was no onco-gene c-fos expression in RPE cells cultured under normal condition. Immediately after 30 minutes of light exposure, onco-gene c-fos expression occurred in the RPE cells. The expression reached the highest level 1.5 hours after light exposure and disappeared 4 hours later. Taurine and gamma-interferon in different concentrations could restrain onco-gene c-fos expression in light damaged RPE cells. The restraint effects were of concentration dependence.
Liang
Y
Y
Department of Ophthalmology, Third Hospital of Beijing Medical University.
Zhang
H
H
Cao
J
J
D002478:Cells, Cultured; D015870:Gene Expression / Q000187:drug effects; D016762:Genes, fos; D006801:Humans; D007371:Interferon-gamma / Q000494:pharmacology*; D008027:Light; D010857:Pigment Epithelium of Eye / Q000166:cytology* / Q000196:embryology; D013654:Taurine / Q000494:pharmacology*
D013654:Taurine; D007371:Interferon-gamma