title: A custom distal femoral prosthesis for reconstruction of large defects following wide excision for sarcoma: results and prognostic factors.
abstract: Between 1979 and 1986, 37 patients with sarcoma of the distal femur underwent limb salvage using a custom prosthetic knee replacement. Thirteen (35%) had early complications. Fourteen (38%) had late complications, which consisted of 6 aseptic femoral loosenings, 1 aseptic tibial loosening, 2 tibial fractures, 2 contractures, 1 femoral fracture, 1 prosthetic fracture, and 1 septic loosening. By 1988, nine patients died. Thirteen prostheses failed in 12 patients, resulting in 9 revisions, 2 above-knee amputations, and 2 Van Nes rotationplasties. The 2- and 5-year prosthetic survival rates were 82% and 57%, respectively. Twenty-two of the 26 survivors (85%) had successful limb salvage. Preventable factors were implicated in the loosening of six femoral components and in one femoral fracture. The mean Hospital for Special Surgery Knee Score was 69 (range: 62 to 86).
authors.affiliation: Department of Orthopedic Surgery, Cleveland Clinic, OH 44195, USA.
authors.forename: G F
authors.initials: GF
authors.lastname: Muschler
authors.forename: K
authors.initials: K
authors.lastname: Ihara
authors.forename: J M
authors.initials: JM
authors.lastname: Lane
authors.forename: J H
authors.initials: JH
authors.lastname: Healey
authors.forename: M J
authors.initials: MJ
authors.lastname: Levine
authors.forename: J C
authors.initials: JC
authors.lastname: Otis
authors.forename: A H
authors.initials: AH
authors.lastname: Burstein
mesh_terms: D000293:Adolescent; D000328:Adult; D005260:Female; D005266:Femoral Neoplasms / Q000601:surgery*; D005269:Femur; D006801:Humans; D007720:Knee Prosthesis / Q000009:adverse effects / Q000295:instrumentation / Q000379:methods / Q000706:statistics & numerical data; D008297:Male; D008875:Middle Aged; D010147:Pain Measurement; D011183:Postoperative Complications; D011379:Prognosis; D011474:Prosthesis Design; D011475:Prosthesis Failure; D012086:Reoperation; D012307:Risk Factors; D012509:Sarcoma / Q000601:surgery*