title: Thrombus associated with mitral valve calcification. A possible mechanism for embolic stroke.
abstract: BACKGROUND
  Several studies have demonstrated an association between mitral annular calcification and stroke; however, the pathophysiological explanation remains speculative.
  
  
  METHODS
  We describe two patients with cerebral embolism in whom mitral valve calcification was demonstrated by transthoracic echocardiography. In both patients, transesophageal echocardiography identified a mass that appeared to be thrombus on the calcified portion of the mitral apparatus. There was no evidence of a hypercoagulable state or endocarditis in either case. Repeated transesophageal echocardiography after anticoagulation demonstrated resolution of the masses in both patients.
  
  
  CONCLUSIONS
  These cases support the hypothesis that thrombus formation may be a pathophysiological link between ischemic cerebral events and mitral annular calcification in some patients.
authors.affiliation: Department of Medicine, Rush Medical College, Chicago, Ill, USA.
authors.forename: J H
authors.initials: JH
authors.lastname: Stein
authors.forename: J S
authors.initials: JS
authors.lastname: Soble
mesh_terms: D000368:Aged; D002545:Brain Ischemia / Q000209:etiology; D002114:Calcinosis / Q000150:complications* / Q000000981:diagnostic imaging; D002544:Cerebral Infarction / Q000209:etiology; D002561:Cerebrovascular Disorders / Q000209:etiology*; D004452:Echocardiography; D017548:Echocardiography, Transesophageal; D005260:Female; D006349:Heart Valve Diseases / Q000150:complications / Q000000981:diagnostic imaging; D006801:Humans; D002542:Intracranial Embolism and Thrombosis / Q000209:etiology*; D008875:Middle Aged; D008943:Mitral Valve / Q000000981:diagnostic imaging / Q000473:pathology*; D013927:Thrombosis / Q000150:complications* / Q000000981:diagnostic imaging; D014859:Warfarin / Q000627:therapeutic use
chemical_list: D014859:Warfarin