[Protein subunit vaccines: example of vaccination against hepatitis B virus].
Hepatitis B vaccine has been used for over 10 years. It is efficient and safe. Protection of risk groups against hepatitis B virus infection is now achieved and vaccination of newborns and adolescents is a main public health problem. Bad responders are well characterized and immunomodulatory interventions (cytokines) must be tested in these patients. Response to hepatitis B vaccine is genetically determined and the possibility of vaccine induced escape mutants should lead to careful epidemiological studies of the spread of hepatitis B virus infection.
Degos
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Service d'hépatologie Hôpital Beaujon, Clichy.
D017325:Hepatitis B Vaccines / Q000145:classification / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D016867:Immunocompromised Host; D009154:Mutation; D014611:Vaccination / Q000379:methods
D017325:Hepatitis B Vaccines
Vaccins sous-unités protéiques: exemple de la vaccination contre le virus de l'hépatite B.