(5aR,11bS)-4,5,5a,6,7,11b-hexahydro-2-propyl-3-thia-5-azacyclopent-1- ena[c]-phenanthrene-9,10-diol (A-86929): a potent and selective dopamine D1 agonist that maintains behavioral efficacy following repeated administration and characterization of its diacetyl prodrug (ABT-431).
Michaelides
M R
MR
Abbott Laboratories, Abbott Park, Illinois 60064-3500, USA.
Hong
Y
Y
DiDomenico
S
S
Asin
K E
KE
Britton
D R
DR
Lin
C W
CW
Williams
M
M
Shiosaki
K
K
D000107:Acetylation; D000818:Animals; D001522:Behavior, Animal / Q000187:drug effects; D004334:Drug Administration Schedule; D006801:Humans; D011355:Prodrugs / Q000737:chemistry / Q000494:pharmacology*; D011498:Protein Precursors / Q000378:metabolism; D011725:Pyridines / Q000737:chemistry / Q000494:pharmacology*; D015363:Quinolones; D051381:Rats; D017447:Receptors, Dopamine D1 / Q000819:agonists* / Q000378:metabolism; D017448:Receptors, Dopamine D2 / Q000378:metabolism; D013329:Structure-Activity Relationship; D013764:Tetrahydronaphthalenes / Q000737:chemistry / Q000494:pharmacology*; D013876:Thiophenes
D011355:Prodrugs; D011498:Protein Precursors; D011725:Pyridines; D015363:Quinolones; D017447:Receptors, Dopamine D1; D017448:Receptors, Dopamine D2; D013764:Tetrahydronaphthalenes; D013876:Thiophenes; C095428:adrogolide hydrochloride; C095427:A 86929