The metabolism of n-nonane in male Fischer 344 rats.
The urinary metabolites of n-nonane in male Fischer 344 rats, after administering the hydrocarbon by gavage, included gamma-valerolactone, delta-hexanolactone, 2,5-hexanedione, delta-heptanolactone, 1-heptanol, 2-nonanol, 3-nonanol, 4-nonanol, 4-nonanone and 5-methyl-2-(3-oxobutyl)furan. Metabolism strongly favored the formation of monoalcohols and lactones, which are the products of appropriately substituted hydroxy carboxylic acids. The metabolites were identified using gas chromatography (GC) and gas chromatography/mass spectrometry (GC/MS). High pressure liquid chromatography (HPLC) permitted the detection of the dicarboxylic acids malonic acid and glutaric acid in the n-nonane dosed rat urines.
Serve
M P
MP
Department of Chemistry, Wright State University, Dayton, OH 45435, USA.
Bombick
D D
DD
Baughman
T M
TM
Jarnot
B M
BM
Ketcha
M
M
Mattie
D R
DR
D000438:Alcohols / Q000652:urine; D000473:Alkanes / Q000378:metabolism* / Q000652:urine; D000818:Animals; D002851:Chromatography, High Pressure Liquid; D005663:Furans / Q000652:urine; D008401:Gas Chromatography-Mass Spectrometry; D006588:Hexanones / Q000652:urine; D007783:Lactones / Q000378:metabolism / Q000652:urine; D008297:Male; D051381:Rats; D011916:Rats, Inbred F344
D000438:Alcohols; D000473:Alkanes; D005663:Furans; D006588:Hexanones; D007783:Lactones; C011269:2,5-hexanedione; C017573:nonane