Cholinergic toxicity resulting from ocular instillation of echothiophate iodide eye drops.
A patient developed a severe cholinergic syndrome from the use of echothiophate iodide ophthalmic drops, presented with profound muscle weakness and was initially given the diagnosis of myasthenia gravis. Red blood cell and serum cholinesterase levels were severely depressed and symptoms resolved spontaneously following discontinuation of the eye drops.
Manoguerra
A
A
San Diego Regional Poison Center, UCSD Medical Center 92103-8925, USA.
Whitney
C
C
Clark
R F
RF
Anderson
B
B
Turchen
S
S
D000368:Aged; D002802:Cholinesterases / Q000097:blood; D004456:Echothiophate Iodide / Q000009:adverse effects* / Q000627:therapeutic use; D005260:Female; D005901:Glaucoma / Q000188:drug therapy; D006801:Humans; D009123:Muscle Hypotonia / Q000139:chemically induced*; D018482:Muscle, Skeletal / Q000187:drug effects; D009157:Myasthenia Gravis / Q000097:blood / Q000175:diagnosis; D009883:Ophthalmic Solutions / Q000009:adverse effects
D009883:Ophthalmic Solutions; D004456:Echothiophate Iodide; D002802:Cholinesterases