Activities of extracts and naphthylisoquinoline alkaloids from Triphyophyllum peltatum, Ancistrocladus abbreviatus and Ancistrocladus barteri against Plasmodium berghei (Anka strain) in vitro.
Extracts from three tropical medicinal plant species belonging to the Dioncophyllaceae (Triphyophyllum peltatum) and the Ancistrocladaceae (Ancistrocladus abbreviatus and Ancistrocladus barteri), and pure naphthylisoquinoline alkaloids derived from these species have been examined for the first time for their activity against asexual blood forms of Plasmodium berghei (Anka strain) in vitro. These activities were considerable and comparable with those earlier found against erythrocytic forms of Plasmodium falciparum. The extracts and constituents of species belonging to the Dioncophyllaceae (dioncophylline B, dioncopeltine A and dioncophylline A) appear to be more promising than those from the Ancistrocladaceae.
François
G
G
Laboratorium voor Protozoölogie, Instituut voor Tropische Geneeskunde, Antwerpen, Belgium.
Bringmann
G
G
Dochez
C
C
Schneider
C
C
Timperman
G
G
Aké Assi
L
L
D000470:Alkaloids / Q000302:isolation & purification / Q000494:pharmacology*; D000818:Animals; D005260:Female; D007546:Isoquinolines / Q000302:isolation & purification / Q000494:pharmacology*; D051379:Mice; D010936:Plant Extracts / Q000494:pharmacology*; D010946:Plants, Medicinal; D010962:Plasmodium berghei / Q000187:drug effects* / Q000254:growth & development / Q000528:radiation effects; D010963:Plasmodium falciparum / Q000187:drug effects / Q000254:growth & development / Q000528:radiation effects; D012015:Reference Standards; D013329:Structure-Activity Relationship
D000470:Alkaloids; D007546:Isoquinolines; D010936:Plant Extracts