title: Hypoxic-ischemic encephalopathy. Therapeutic approaches against microvascular injury, and role of neutrophils, PAF, and free radicals.
abstract: The asphyxiated newborn undergoes progressive brain damage even after resuscitation. This article reviews the microvascular events that contribute to evolving brain injury. The role of neutrophils, platelet-activating factor (PAF), and free radicals is stressed as pivotal mechanisms of injury and opportunities for therapeutic intervention.
authors.affiliation: Department of Pediatrics, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey, USA.
authors.forename: C
authors.initials: C
authors.lastname: Palmer
mesh_terms: D000818:Animals; D000975:Antioxidants / Q000627:therapeutic use; D001238:Asphyxia Neonatorum / Q000150:complications*; D001921:Brain / Q000098:blood supply* / Q000378:metabolism; D001925:Brain Damage, Chronic / Q000209:etiology / Q000517:prevention & control; D002545:Brain Ischemia / Q000209:etiology* / Q000628:therapy*; D002415:Cats; D002560:Cerebrovascular Circulation; D005609:Free Radicals; D006801:Humans; D002534:Hypoxia, Brain / Q000209:etiology* / Q000628:therapy*; D007231:Infant, Newborn; D008833:Microcirculation; D009504:Neutrophils / Q000502:physiology*; D010972:Platelet Activating Factor / Q000502:physiology*; D051381:Rats; D015427:Reperfusion Injury / Q000209:etiology / Q000517:prevention & control
chemical_list: D000975:Antioxidants; D005609:Free Radicals; D010972:Platelet Activating Factor