title: Polyunsaturated fatty acids recruit brown adipose tissue: increased UCP content and NST capacity.
abstract: To examine the effect of polyunsaturated fatty acids (PUFA) on brown adipose tissue recruitment and on the capacity for nonshivering thermogenesis (NST), mice were fed a diet with a standard fat content (9%) and a normal PUFA content (1.6%) (controls) or a high-PUFA content (4.3%) for 2-3 wk. The resting metabolic rate was somewhat lower in the high-PUFA group, probably due to a lower physical activity whereas the capacity for NST (estimated as the metabolic response to a norepinephrine injection) was higher in the high-PUFA group. There was no significant effect on brown adipose tissue wet weight, protein content, or cytochrome-c oxidase content, but the amount of the uncoupling protein thermogenin (UCP), measured immunologically, was significantly increased in the high-PUFA mice (totally by 41%). It was concluded that short-term feeding of a high-PUFA diet may recruit brown adipose tissue thermogenic capacity; it was speculated that earlier-reported recruiting effects of high-fat diets may not be due solely to the high total fat content of the diet but perhaps also to a specific recruiting property of the high-PUFA diets generally used in this type of investigation.
authors.affiliation: Arrhenius Laboratories, Wenner-Gren Institute, Stockholm University, Sweden.
authors.forename: A
authors.initials: A
authors.lastname: Sadurskis
authors.forename: A
authors.initials: A
authors.lastname: Dicker
authors.forename: B
authors.initials: B
authors.lastname: Cannon
authors.forename: J
authors.initials: J
authors.lastname: Nedergaard
mesh_terms: D002001:Adipose Tissue, Brown / Q000187:drug effects* / Q000378:metabolism / Q000502:physiology*; D000818:Animals; D001833:Body Temperature Regulation; D001835:Body Weight; D002352:Carrier Proteins / Q000378:metabolism*; D004435:Eating; D005231:Fatty Acids, Unsaturated / Q000494:pharmacology*; D007473:Ion Channels; D008297:Male; D008565:Membrane Proteins / Q000378:metabolism*; D051379:Mice; D008815:Mice, Inbred Strains; D008928:Mitochondria / Q000378:metabolism; D024101:Mitochondrial Proteins; D009638:Norepinephrine / Q000494:pharmacology; D012146:Rest; D000071256:Uncoupling Protein 1
chemical_list: D002352:Carrier Proteins; D005231:Fatty Acids, Unsaturated; D007473:Ion Channels; D008565:Membrane Proteins; D024101:Mitochondrial Proteins; D000071256:Uncoupling Protein 1; D009638:Norepinephrine