title: Biocompatibility of chemical-vapour-deposited diamond.
abstract: The biocompatibility of chemical-vapour-deposited (CVD) diamond surfaces has been assessed. Our results indicate that CVD diamond is as biocompatible as titanium (Ti) and 316 stainless steel (SS). First, the amount of adsorbed and 'denatured' fibrinogen on CVD diamond was very close to that of Ti and SS. Second, both in vitro and in vivo there appears to be less cellular adhesion and activation on the surface of CVD diamond surfaces compared to Ti and SS. This evident biocompatibility, coupled with the corrosion resistance and notable mechanical integrity of CVD diamond, suggests that diamond-coated surfaces may be highly desirable in a number of biomedical applications.
authors.affiliation: Biomedical Engineering Program, University of Minnesota, Minneapolis 55455, USA.
authors.forename: L
authors.initials: L
authors.lastname: Tang
authors.forename: C
authors.initials: C
authors.lastname: Tsai
authors.forename: W W
authors.initials: WW
authors.lastname: Gerberich
authors.forename: L
authors.initials: L
authors.lastname: Kruckeberg
authors.forename: D R
authors.initials: DR
authors.lastname: Kania
mesh_terms: D000042:Absorption; D001672:Biocompatible Materials; D002448:Cell Adhesion / Q000502:physiology; D003300:Copper / Q000737:chemistry / Q000378:metabolism; D018130:Diamond / Q000737:chemistry* / Q000378:metabolism; D005340:Fibrinogen / Q000378:metabolism*; D006801:Humans; D008855:Microscopy, Electron, Scanning; D009504:Neutrophils / Q000166:cytology / Q000502:physiology / Q000648:ultrastructure; D019736:Prostheses and Implants / Q000592:standards; D011489:Protein Denaturation; D013193:Stainless Steel / Q000737:chemistry; D014025:Titanium / Q000737:chemistry / Q000378:metabolism; D014835:Volatilization
chemical_list: D001672:Biocompatible Materials; D013193:Stainless Steel; D018130:Diamond; D003300:Copper; D005340:Fibrinogen; D014025:Titanium