Anaphylactoid and anaphylactic reactions. Hazards of beta-blockers.
Studies have demonstrated greater hazards associated with anaphylaxis in patients receiving beta-blockers. Serious anaphylaxis is more frequent. Evidence suggests this occurs via modulation of adenylate cyclase, which can influence release of anaphylactogenic mediators. Treatment of anaphylaxis in patients exposed to beta-blockers is complicated because therapeutic administration of epinephrine (adrenaline) may be ineffective or promote undesired alpha-adrenergic and vagotonic effects. Risk reduction efforts should be considered for patients receiving beta-blockers who are prone to experience anaphylaxis.
Lang
D M
DM
Department of Medicine, Hahnemann University Hospital, Philadelphia, USA.
D000319:Adrenergic beta-Antagonists / Q000009:adverse effects* / Q000493:pharmacokinetics; D000707:Anaphylaxis / Q000139:chemically induced*; D006801:Humans
D000319:Adrenergic beta-Antagonists