[Development of biochemical and histopathological parameters in paracetamol overdose in experimental cholestasis].
The aim of the present paper is to determine the effect of Paracetamol (P) acute intoxication in cholestatic rats. Four groups of animals were considered: controls, controls intoxicated with P, rats intoxicated with P and cholestatic rats. Hepatic biochemical tests and liver histology were performed in every group. It is concluded that cholestatic rats intoxicated with P showed less Liver damage than in control groups.
Ouvińa
G
G
Cátedra de Fisiopatología, Facultad de Farmacia y Bioquímica Universidad de Buenos Aires, Argentina.
Perazzo
J C
JC
Di Carlo
M
M
Negri
G
G
Lago
N
N
Lemberg
A
A
Bengochea
L
L
D000082:Acetaminophen / Q000008:administration & dosage / Q000378:metabolism / Q000633:toxicity*; D000208:Acute Disease; D000818:Animals; D001651:Cholestasis, Extrahepatic / Q000139:chemically induced* / Q000201:enzymology; D062787:Drug Overdose; D014453:Glucuronosyltransferase / Q000378:metabolism; D008099:Liver / Q000187:drug effects / Q000201:enzymology / Q000473:pathology; D008297:Male; D051381:Rats; D017208:Rats, Wistar
D000082:Acetaminophen; D014453:Glucuronosyltransferase
Evolución de parámetros bioquímicos e histopatológicos en la sobredosis con paracetamol durante la colestasis experimental.