[Effect of tranilast ophthalmic solution on allergic conjunctivitis in guinea pigs].
The effect of the ophthalmic solution of tranilast, an anti-allergic agent, on allergic conjunctivitis was studied in passively sensitized guinea pigs. We determined the content of uranine dye and histamine in tears and histopathologically examined palpebral conjunctiva. After instillation of antigen into the conjunctival sac, inflammation of the palpebral conjunctiva, an increase in leaked dye and the release of histamine were found. In the histopathological study, tranilast (1.0%) suppressed the appearance of edema and infiltration of inflammatory cells. Tranilast suppressed the leakage of uranine in a dose-dependent manner. A 0.5% solution of diphenhydramine also showed the inhibitory effect on the leakage of uranine. The inhibitory effect of 0.5% tranilast on antigen-induced dye leakage and histamine release lasted for 6 hr. These results suggest that topically applied tranilast is effective for allergic conjunctivitis.
Itoh
F
F
Pharmacological Laboratories, Kissei Pharmaceutical Co., Ltd., Nagano, Japan.
Komatsu
Y
Y
Taya
F
F
Isaji
M
M
Kojima
M
M
Momose
Y
Y
Suzawa
H
H
Miyata
H
H
Shibazaki
T
T
D000818:Animals; D003228:Conjunctiva / Q000473:pathology; D003233:Conjunctivitis, Allergic / Q000188:drug therapy* / Q000473:pathology; D004205:Cromolyn Sodium / Q000494:pharmacology; D004155:Diphenhydramine / Q000494:pharmacology; D019793:Fluorescein; D005452:Fluoresceins / Q000032:analysis; D006168:Guinea Pigs; D006632:Histamine / Q000032:analysis; D006634:Histamine H1 Antagonists / Q000008:administration & dosage / Q000627:therapeutic use*; D008297:Male; D009883:Ophthalmic Solutions; D013666:Tears / Q000737:chemistry; D062367:ortho-Aminobenzoates / Q000008:administration & dosage / Q000627:therapeutic use*
D005452:Fluoresceins; D006634:Histamine H1 Antagonists; D009883:Ophthalmic Solutions; D062367:ortho-Aminobenzoates; D006632:Histamine; D004155:Diphenhydramine; C012293:tranilast; D004205:Cromolyn Sodium; D019793:Fluorescein