title: Linkage of a gene for dominant non-syndromic deafness to chromosome 19.
abstract: Inherited hearing impairment can occur either in the presence of other clinical features (syndromic hearing loss, SHL) or in isolation (non-syndromic hearing loss, NSHL). The latter is more common and is highly heterogeneous. To date, six NSHL loci have been mapped. We report the identification of a seventh locus (DFNA4) on chromosome 19q13 and suggest DM kinase as a possible candidate gene.
authors.affiliation: Department of Otolaryngology, University of Iowa, Iowa City 52242, USA.
authors.forename: A H
authors.initials: AH
authors.lastname: Chen
authors.forename: L
authors.initials: L
authors.lastname: Ni
authors.forename: K
authors.initials: K
authors.lastname: Fukushima
authors.forename: J
authors.initials: J
authors.lastname: Marietta
authors.forename: M
authors.initials: M
authors.lastname: O'Neill
authors.forename: P
authors.initials: P
authors.lastname: Coucke
authors.forename: P
authors.initials: P
authors.lastname: Willems
authors.forename: R J
authors.initials: RJ
authors.lastname: Smith
mesh_terms: D002874:Chromosome Mapping; D002888:Chromosomes, Human, Pair 19; D003638:Deafness / Q000235:genetics*; D005260:Female; D005799:Genes, Dominant; D008040:Genetic Linkage; D006801:Humans; D008297:Male; D065636:Myotonin-Protein Kinase; D010375:Pedigree; D017346:Protein Serine-Threonine Kinases / Q000235:genetics
chemical_list: C585517:DMPK protein, human; D065636:Myotonin-Protein Kinase; D017346:Protein Serine-Threonine Kinases