title: Seizure after flumazenil administration in a pediatric patient.
abstract: Flumazenil is a benzodiazepine receptor antagonist used to reverse sedation and respiratory depression induced by benzodiazepines. Seizures and cardiac arrhythmias have complicated its use in adult patients. Overdose patients who have coingested tricyclic antidepressants have a higher risk of these complications. Little information exists concerning adverse effects of flumazenil in children. We report the occurrence of a generalized tonic-clonic seizure in a pediatric patient following the administration of flumazenil.
authors.affiliation: Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee 37232-2591, USA.
authors.forename: A T
authors.initials: AT
authors.lastname: McDuffee
authors.forename: J D
authors.initials: JD
authors.lastname: Tobias
mesh_terms: D000293:Adolescent; D000929:Antidepressive Agents, Tricyclic / Q000506:poisoning*; D002648:Child; D002675:Child, Preschool; D062787:Drug Overdose / Q000188:drug therapy; D005260:Female; D005442:Flumazenil / Q000009:adverse effects* / Q000627:therapeutic use; D006801:Humans; D008297:Male; D012640:Seizures / Q000139:chemically induced*
chemical_list: D000929:Antidepressive Agents, Tricyclic; D005442:Flumazenil