Acute myeloblastic leukemia (M2) with translocation (7;11) followed by marked eosinophilia and additional abnormalities of chromosome 5.
We present an 18-year-old woman who was diagnosed with acute myeloblastic leukemia (AML M2), and in whom chromosome analysis of bone marrow cells revealed t(7;11), an abnormality rarely found in leukemias with a differentiation potency. She relapsed 1 year after complete remission was achieved by chemotherapy. Bone marrow examination then revealed a t(7;11) abnormality in 48 of 50 metaphases examined, even when there were less than 7.5% leukemic blasts in the marrow, indicating that the morphologically normal cells were derived from leukemic blasts. The number of leukemia clones with the additional abnormalities in chromosome 5 increased, with concurrent development of eosinophilia, fever, asthma-like symptoms, erythema, itching, and hepatosplenomegaly. Elevation of interleukin 5 (IL-5) in serum and an enhanced expression of IL-5 mRNA were also detected. The increase in IL-5 may have been produced by an abnormality on chromosome 5.
Abe
A
A
First Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Tanimoto
M
M
Towatari
M
M
Matsuoka
A
A
Kitaori
K
K
Kato
H
H
Toyozumi
H
H
Takeo
T
T
Adachi
K
K
Emi
N
N
D000293:Adolescent; D001483:Base Sequence; D002869:Chromosome Aberrations / Q000097:blood / Q000235:genetics*; D025063:Chromosome Disorders; D002880:Chromosomes, Human, Pair 11; D002895:Chromosomes, Human, Pair 5; D002897:Chromosomes, Human, Pair 7; D016207:Cytokines / Q000097:blood; D004802:Eosinophilia / Q000097:blood / Q000235:genetics*; D005260:Female; D006801:Humans; D007621:Karyotyping; D015470:Leukemia, Myeloid, Acute / Q000235:genetics*; D008969:Molecular Sequence Data; D014178:Translocation, Genetic
D016207:Cytokines