Therapy-related acute myeloid leukemia with t(8;16)(p11;p13) following anthracycline-based therapy for nonmetastatic osteosarcoma.
A case of therapy-related AML with t(8;16)(p11;p13) 14 months following the end of anthracycline-containing chemotherapy for a nonmetastatic osteosarcoma of the left tibia is presented. The patient was successfully treated with intensive remission-induction chemotherapy. Subsequently, he underwent an uncomplicated allogeneic bone marrow transplantation from his HLA-identical brother and is at present alive and disease-free 10 months after diagnosis of the secondary AML.
Demuynck
H
H
Department of Hematology, University Hospital Gasthuisberg, Leuven, Belgium.
Verhoef
G E
GE
Zachée
P
P
Vandenberghe
P
P
Van Orshoven
A
A
Paridaens
R
R
Samson
I
I
Boogaerts
M A
MA
D000208:Acute Disease; D000328:Adult; D000971:Antineoplastic Combined Chemotherapy Protocols / Q000009:adverse effects*; D001859:Bone Neoplasms / Q000188:drug therapy*; D002945:Cisplatin / Q000008:administration & dosage; D004317:Doxorubicin / Q000008:administration & dosage; D006801:Humans; D007621:Karyotyping; D007951:Leukemia, Myeloid / Q000139:chemically induced / Q000235:genetics*; D008297:Male; D012516:Osteosarcoma / Q000188:drug therapy*; D013977:Tibia; D014178:Translocation, Genetic
D004317:Doxorubicin; D002945:Cisplatin