title: Efficacy of the acaricide: acardust for the prevention of asthma and rhinitis due to dust mite allergy, in children.
abstract: A double blind, randomized, comparative study versus placebo, was done during 6 months in 32 children, aged 4-12 years, who suffer from either allergic asthma or rhinitis or both, slept in a bedroom rich in dust mite, have well documented allergy solely to house dust mite (H.D.M.), and a condition severe enough to require continuous medication. After thorough cleaning, their bedrooms were sprayed on day 0 and day 90 with the total content of a canister containing either Acardust or Placebo. Rooms were cleaned regularly throughout the study period. Each child completed an individual daily score card (scales from 0-3) for asthma, and rhinitis symptoms, medication taken, and any additional symptoms. Peak flow was recorded twice weekly. All the children were examined every month (at the clinic) when also PFF, FEVI, doctor's and patient's opinion of clinical symptoms were recorded according to the same scale (0-3) and dust samples from child's bedroom were examined for H.D.M. antigen content. At day 0, 90 and 180, total IgE and dust mite specific IgE determination was done. At the end of the study, patient's and doctor's opinion about the spray's efficacy were recorded on a scale from 0-3. The results were in favor of Acardust for asthma, according to patient's opinion (p = 0.001), doctor's opinion (p = 0.04) and individual score cards (p = 0.03), and for nasal secretion (p = 0.01), sneezing and lacrimation (p = 0.02); concurrent medication dropped significantly (p = 0.01) in the Acardust group. No side-effects were reported. We consider Acardust a safe and valuable preventive treatment in H.D.M. allergy.
authors.affiliation: Kaplan Hospital, Tel Aviv, Israel.
authors.forename: C
authors.initials: C
authors.lastname: Geller-Bernstein
authors.forename: J M
authors.initials: JM
authors.lastname: Pibourdin
authors.forename: A
authors.initials: A
authors.lastname: Dornelas
authors.forename: J
authors.initials: J
authors.lastname: Fondarai
mesh_terms: D000487:Allethrins; D000818:Animals; D001249:Asthma / Q000517:prevention & control*; D002648:Child; D002675:Child, Preschool; D004311:Double-Blind Method; D004338:Drug Combinations; D005260:Female; D006801:Humans; D007306:Insecticides; D008297:Male; D008925:Mites; D010882:Piperonyl Butoxide; D012220:Rhinitis / Q000517:prevention & control*
chemical_list: D000487:Allethrins; D004338:Drug Combinations; D007306:Insecticides; C095596:esdepallethin - piperonyl butoxide; D010882:Piperonyl Butoxide