Mucosubstance-rich myxoid stromal nodule of the prostate.
A stromal tumor nodule of the prostate, located in the suburethral region, was incidentally retrieved by transurethral resection in a 72-year-old man with prostatism. Tumor fragments were grossly gelatinous and friable. The nodule consisted of a myxoid population of bland spindle cells lying in a matrix rich in acidic mucosubstance, mostly resistant to hyaluronidase. Capillary and venular vascular grouping and interspersed mast cells were conspicuous features. Phenotypical characterization revealed a population of fibroblasticlike cells. The associated prostatic tissue showed nodular glandular hyperplasia only. Whether this prostatic nodule represents a neoplasm or an unusual variant of hyperplastic stromal nodule is unclear.
Bégin
L R
LR
Department of Pathology, McGill University, Montreal, Quebec.
D000368:Aged; D003937:Diagnosis, Differential; D006025:Glycosaminoglycans / Q000032:analysis; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008854:Microscopy, Electron; D011470:Prostatic Hyperplasia / Q000473:pathology; D011471:Prostatic Neoplasms / Q000737:chemistry / Q000473:pathology* / Q000648:ultrastructure
D006025:Glycosaminoglycans