title: Effect of timing of food on absorption of cefpodoxime proxetil.
abstract: The effect of a high-fat meal and the timing of this meal on the absorption of a 400-mg oral dose of cefpodoxime proxetil was evaluated in 20 healthy, adult, male volunteers in a four-way crossover study. The area under the plasma concentration-time curve, peak plasma concentration, and urinary recovery were significantly greater (P = .0001) after administration of cefpodoxime proxetil tablets with and 2 hours after a meal relative to dosing under fasted conditions or 1 hour before a meal. The time to peak concentration did not differ significantly among treatments, which suggests that food did not affect the rate of drug absorption. These results indicate that absorption of cefpodoxime proxetil is enhanced when tablets are taken with food or shortly after a meal.
authors.affiliation: Upjohn Laboratories, Upjohn Company, Kalamazoo, Michigan 49001-0199, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Borin
authors.forename: M R
authors.initials: MR
authors.lastname: Driver
authors.forename: K K
authors.initials: KK
authors.lastname: Forbes
mesh_terms: D000328:Adult; D015296:Ceftizoxime / Q000031:analogs & derivatives* / Q000493:pharmacokinetics; D018592:Cross-Over Studies; D004036:Diet, Atherogenic; D005502:Food; D018565:Food-Drug Interactions; D006801:Humans; D007408:Intestinal Absorption; D008297:Male; D008875:Middle Aged; D011355:Prodrugs / Q000493:pharmacokinetics*; D013997:Time Factors; D000097627:Cefpodoxime Proxetil
chemical_list: D015296:Ceftizoxime; D011355:Prodrugs; D000097627:Cefpodoxime Proxetil