Adrenalectomy increases the glial fibrillary acidic immunoreactive-elements in the ventricular ependyma and adjacent neuropil of the rat third ventricle.
The reactions of bilateral adrenalectomy (14 days) on the rat glial fibrillary acidic-immunoreactive elements of the third ventricular ependyma and adjacent neuropil were analyzed using histological, immunohistochemical and morphometric methods. Bilateral adrenalectomy led to a drastic increase in the number of immunoreactive elements located in the neuropil adjacent to the third ventricle and the optic chiasm when compared to normal and sham-operated animals (p < 0.05). By contrast, the adrenalectomized animals receiving corticosterone showed the same characteristics and morphometric values as those found in normal and sham-operated animals. The results show that the participation of the adrenal gland in astroglial responses should be taken into account.
Sánchez
F
F
Department of Human Anatomy and Histology, Faculty of Medicine University of Salamanca, Spain.
Hernández
G
G
Rubio
M
M
Santos
M
M
Carretero
J
J
Riesco
J
J
Juanes
J
J
Vázquez
R
R
D000315:Adrenalectomy; D000818:Animals; D002552:Cerebral Ventricles / Q000166:cytology / Q000378:metabolism*; D004805:Ependyma / Q000166:cytology / Q000378:metabolism*; D005904:Glial Fibrillary Acidic Protein / Q000032:analysis / Q000096:biosynthesis*; D007150:Immunohistochemistry; D008297:Male; D009897:Optic Chiasm / Q000166:cytology / Q000378:metabolism*; D051381:Rats; D017207:Rats, Sprague-Dawley; D012016:Reference Values
D005904:Glial Fibrillary Acidic Protein