Identification of a new locus, mus115, in Drosophila melanogaster.
Previous screens for autosomal genes that are necessary for resistance to DNA cross-linking agents but not to monofunctional agents have produced 6 mutations; all of which fall within the third chromosomal gene mus308. In an effort to identify analogous sex-linked genes, a screen of mutagenized X-chromosomes has been conducted for mutations that confer hypersensitivity to nitrogen mustard. This search has identified a new locus, mus115, through the recovery of a mutant that is strongly hypersensitive to nitrogen mustard but marginally sensitive to methyl methanesulfonate.
Leonhardt
E A
EA
Department of Genetics, University of California, Davis 95616.
Boyd
J B
JB
D000818:Animals; D004331:Drosophila melanogaster / Q000235:genetics*; D005260:Female; D017344:Genes, Insect / Q000187:drug effects*; D005816:Genetic Complementation Test; D008040:Genetic Linkage; D008297:Male; D008741:Methyl Methanesulfonate / Q000633:toxicity; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009588:Nitrogen Mustard Compounds / Q000633:toxicity; D014960:X Chromosome
D009588:Nitrogen Mustard Compounds; D008741:Methyl Methanesulfonate