title: Experimental neurocytomas.
abstract: Four ethyl-nitrosourea (ENU)-induced oligodendroglioma-like tumors of the rat showing large rosettes on haematoxylin-eosin stain were studied by means of immunohistochemistry and electron microscopy, and their features compared with six human intraventricular neurocytomas. The similarities between the experimental and human tumors studied support the hypothesis that most of the so-called ENU-induced oligodendrogliomas in the rat are primitive neuroectodermal tumors with the tendency to differentiate toward a neuronal phenotype, and also suggest that the ENU-model of neurocarcinogenesis is useful for the induction of experimental neurocytomas.
authors.affiliation: Neurosurgical Department, Puerta de Hierro Clinic, Autonomous University, Madrid, Spain.
authors.forename: J
authors.initials: J
authors.lastname: Vaquero
authors.forename: S
authors.initials: S
authors.lastname: Coca
authors.forename: M
authors.initials: M
authors.lastname: Zurita
authors.forename: S
authors.initials: S
authors.lastname: Oya
authors.forename: A
authors.initials: A
authors.lastname: Arias
authors.forename: C
authors.initials: C
authors.lastname: Morales
authors.forename: J
authors.initials: J
authors.lastname: Buján
authors.forename: N
authors.initials: N
authors.lastname: García
mesh_terms: D000818:Animals; D001932:Brain Neoplasms / Q000139:chemically induced* / Q000473:pathology / Q000648:ultrastructure; D004801:Eosine Yellowish-(YS); D005038:Ethylnitrosourea; D005904:Glial Fibrillary Acidic Protein / Q000378:metabolism; D006416:Hematoxylin; D006801:Humans; D007150:Immunohistochemistry; D051379:Mice; D008854:Microscopy, Electron; D009447:Neuroblastoma / Q000139:chemically induced* / Q000473:pathology / Q000648:ultrastructure; D009837:Oligodendroglioma / Q000139:chemically induced / Q000473:pathology / Q000648:ultrastructure; D016612:Paraffin Embedding; D010641:Phenotype; D051381:Rats; D017208:Rats, Wistar; D016708:Synaptophysin / Q000096:biosynthesis; D014746:Vimentin / Q000378:metabolism
chemical_list: D005904:Glial Fibrillary Acidic Protein; D016708:Synaptophysin; D014746:Vimentin; D005038:Ethylnitrosourea; D004801:Eosine Yellowish-(YS); D006416:Hematoxylin