Molluscan ligand-gated ion-channel receptors.
In this chapter we introduce the reader to the structures of the different types of ligand-gated ion-channel receptor, and the numerous receptor subtypes that have recently been revealed to exist, in both invertebrate and vertebrate species, by the application of molecular biological methods. We then review some of the data in support of the existence, in molluscs, of such receptor/channel complexes for gamma-aminobutyric acid, glutamate and acetylcholine. Finally, recent results from our laboratory on the cloning and expression of complementary DNAs, from the pond-snail Lymnaea stagnalis, that encode GABA(A) and glutamate receptor subunits will be described.
Darlison
M G
MG
Institut für Zellbiochemie, Universitäts-Krankenhaus Eppendorf, Hamburg, Germany.
Hutton
M L
ML
Harvey
R J
RJ
D000595:Amino Acid Sequence; D000818:Animals; D004247:DNA / Q000235:genetics; D007473:Ion Channels / Q000235:genetics / Q000502:physiology*; D008969:Molecular Sequence Data; D008974:Mollusca / Q000502:physiology*; D009474:Neurons / Q000502:physiology*; D017433:Protein Structure, Secondary; D011950:Receptors, Cholinergic / Q000235:genetics / Q000502:physiology*; D011963:Receptors, GABA-A / Q000235:genetics / Q000502:physiology*; D017470:Receptors, Glutamate / Q000235:genetics / Q000502:physiology*
D007473:Ion Channels; D011950:Receptors, Cholinergic; D011963:Receptors, GABA-A; D017470:Receptors, Glutamate; D004247:DNA