Mouse strain differences in induction of micronuclei by base analogues and nucleosides.
The frequency of induced micronucleated polychromatic erythrocytes (MNPCEs) was compared in BALB/c, C57BL/6, and DBA/2 mice after intraperitoneal (i.p.) injection of 5-bromodeoxyuridine (BUdR), 5-fluorodeoxyuridine (FUdR), cytosine arabinoside (Ara-C), 6-mercaptopurine (6-MP), 5-bromouracil (5-BU), thymidine (TdR), uridine (UdR), adenosine (AdR) and guanosine (GdR). The experimental procedure was a single i.p. injection followed by harvest at 30 h. The frequency of MNPCEs was significantly increased in all strains by treatment with BUdR, FUdR, Ara-C and 6-MP compared to vehicle control. TdR and UdR induced MNPCEs slightly in BALB/c mice but showed no effect on C57BL/6 and DBA/2 mice. 5-BU, AdR, and GdR did not increase the frequency of MNPCEs in any mouse strain used. These results suggest that BALB/c mice are more susceptible to induction of MNPCEs by clastogenic base analogues and nucleosides than are C57BL/6 or DBA/2 mice.
Sato
S
S
Toxicology Research Laboratories, Japan Tobacco Inc., Kanagawa.
Takizawa
H
H
Inui
N
N
D000225:Adenine / Q000633:toxicity; D000818:Animals; D001973:Bromodeoxyuridine / Q000633:toxicity; D001976:Bromouracil / Q000633:toxicity; D003561:Cytarabine / Q000633:toxicity; D004912:Erythrocytes / Q000187:drug effects; D005260:Female; D005467:Floxuridine / Q000633:toxicity; D006151:Guanosine / Q000633:toxicity; D015122:Mercaptopurine / Q000633:toxicity; D051379:Mice / Q000235:genetics*; D008807:Mice, Inbred BALB C / Q000235:genetics; D008810:Mice, Inbred C57BL / Q000235:genetics; D008811:Mice, Inbred DBA / Q000235:genetics; D015162:Micronucleus Tests; D008934:Mitogens / Q000633:toxicity*; D009705:Nucleosides / Q000633:toxicity*; D011687:Purines / Q000633:toxicity*; D011743:Pyrimidines / Q000633:toxicity*; D013045:Species Specificity; D013936:Thymidine / Q000633:toxicity; D014529:Uridine / Q000633:toxicity
D008934:Mitogens; D009705:Nucleosides; D011687:Purines; D011743:Pyrimidines; D005467:Floxuridine; D003561:Cytarabine; D006151:Guanosine; D001976:Bromouracil; D015122:Mercaptopurine; D001973:Bromodeoxyuridine; D000225:Adenine; D013936:Thymidine; D014529:Uridine