Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians.
As part of a community-based study of Alzheimer's Disease (AD) in a Nigerian population aged 65 years and over, we have determined apolipoprotein E (APOE) genotypes on 56 subjects (39 controls and 17 subjects with dementia, including 12 with AD). The epsilon 4 allele of APOE was not associated with AD or dementia in this community-based sample. The epsilon 4 allele frequency was 17.6% in demented patients and 16.7% in AD patients compared with 20.5% in the control subjects. These findings are in marked contrast to the strong association between the epsilon 4 allele and AD in our previously reported study with African Americans.
Osuntokun
B O
BO
Department of Medicine, University of Ibadan, Nigeria.
Sahota
A
A
Ogunniyi
A O
AO
Gureje
O
O
Baiyewu
O
O
Adeyinka
A
A
Oluwole
S O
SO
Komolafe
O
O
Hall
K S
KS
Unverzagt
F W
FW
D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D000544:Alzheimer Disease / Q000235:genetics*; D053327:Apolipoprotein E4; D001057:Apolipoproteins E / Q000235:genetics*; D003625:Data Collection; D005260:Female; D005787:Gene Frequency; D005838:Genotype; D006801:Humans; D008297:Male; D009549:Nigeria
D053327:Apolipoprotein E4; D001057:Apolipoproteins E