title: [The safety, reactogenicity and antigenic activity of a Pseudomonas aeruginosa anatoxin studied in volunteers].
abstract: The safety, reactogenicity and immunogenic activity of P. aeruginosa toxoid were studied in 46 volunteer donors. Systemic reactions to the injection of the preparation were absent in all vaccinees, in 2 subjects (4.3%) insignificant reactions at the site of injection in the form of hyperemia, sized 13-14 mm and disappearing within 48 hours, were registered. The preparation was found stimulate humoral immunity, which was manifested by an increase in the number of B-rosette-forming lymphocytes and the level of antitoxic IgG in the blood of the vaccinees. Besides, immune sera obtained from the blood of the volunteers were found to possess protective properties.
authors.forename: N A
authors.initials: NA
authors.lastname: Mikhaĭlova
authors.forename: O V
authors.initials: OV
authors.lastname: Kuniagina
authors.forename: T N
authors.initials: TN
authors.lastname: Kuznetsova
authors.forename: A F
authors.initials: AF
authors.lastname: Sadykova
authors.forename: N S
authors.initials: NS
authors.lastname: Brodinova
authors.forename: G N
authors.initials: GN
authors.lastname: Bodrova
mesh_terms: D000327:Adsorption; D000818:Animals; D000942:Antigens, Bacterial / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D004341:Drug Evaluation; D006801:Humans; D007114:Immunization / Q000379:methods; D007136:Immunoglobulins / Q000097:blood; D051379:Mice; D011550:Pseudomonas aeruginosa / Q000276:immunology*; D012449:Safety; D013601:T-Lymphocytes / Q000276:immunology; D014121:Toxoids / Q000009:adverse effects* / Q000276:immunology*
chemical_list: D000942:Antigens, Bacterial; D007136:Immunoglobulins; D014121:Toxoids
vernacular_title: Izuchenie bezopasnosti, reaktogennosti i antigennoĭ aktivnosti anatoksina Pseudomonas aeruginosa na dobrovol'tsakh.