title: Administration of omeprazole to rats for one year produces reciprocal effects on antral gastrin and somatostatin cells and no effect on endocrine cells in the colon.
abstract: Inhibition of acid secretion with high doses of antisecretagogues, such as omeprazole, is known to raise the plasma gastrin levels. In the present study, we examined the effect of long-term (1-year) treatment of female rats with high doses of omeprazole on the density of antral gastrin and somatostatin cells. A possible effect on the endocrine cell density (chromogranin A as marker) and mucosal thickness of the colon was also examined. The plasma gastrin level in the omeprazole-treated rats was increased 15-fold compared with the level in the controls. The gastrin cell density, on the other hand, showed only a 2-fold increase. The somatostatin cell density in the omeprazole-treated rats was half that in the controls, indicating an inverse relationship between antral gastrin and somatostatin. In the colonic mucosa, neither the mucosal thickness nor the number of chromogranin-A-containing endocrine cells were affected by the omeprazole-induced hypergastrinemia. The results indicate that long-term acid inhibition results in a sustained hypergastrinemia, a modest and stable antral gastrin cell hyperplasia, antral somatostatin cell hypoplasia and lack of trophic effects in the colon.
authors.affiliation: Department of Medical Cell Research, University of Lund, Sweden.
authors.forename: F
authors.initials: F
authors.lastname: Sundler
authors.forename: K
authors.initials: K
authors.lastname: Andersson
authors.forename: H
authors.initials: H
authors.lastname: Mattsson
mesh_terms: D000818:Animals; D002452:Cell Count / Q000187:drug effects; D003106:Colon / Q000166:cytology / Q000187:drug effects*; D005260:Female; D005753:Gastric Mucosa / Q000166:cytology / Q000187:drug effects*; D005755:Gastrins / Q000378:metabolism*; D007413:Intestinal Mucosa / Q000166:cytology / Q000187:drug effects*; D009853:Omeprazole / Q000494:pharmacology*; D051381:Rats; D017207:Rats, Sprague-Dawley; D013004:Somatostatin / Q000378:metabolism*; D013997:Time Factors
chemical_list: D005755:Gastrins; D013004:Somatostatin; D009853:Omeprazole