[Humoral antibodies to structural proteins of murine mammary tumor virus as a potential immunologic marker of human breast cancer].
The presence of humoral antibodies specifically recognizing structural proteins of murine mammary tumor virus was studied in indirect immuno-enzymatic reaction, in 79 patients with suspected tumors of the breast. Diagnosis was verified after surgery by histological procedures. Said antibodies were detected in 13% of patients with benign tumors, lymphomas and mammary lymphosarcomas. However, in the breast cancer group including patients with T1-2N0M0 and T1N1M0, antibodies were identified in 85.7% of sera. It is suggested that patients with breast tumors who have antibodies to murine mammary tumor virus develop a specific nosological type of tumor which arises at reproductive age and is capable of high-rate growth and low-level metastatic spreading. Feasibility of application of said procedure for early detection of breast cancer is discussed.
Malivanova
T F
TF
Kriukova
I N
IN
Litvinov
S V
SV
Ermilova
V D
VD
Shirin
D F
DF
Blokhina
N G
NG
D000818:Animals; D000912:Antibodies, Neoplasm / Q000097:blood*; D000914:Antibodies, Viral / Q000097:blood*; D000957:Antigens, Viral, Tumor / Q000276:immunology*; D014408:Biomarkers, Tumor / Q000097:blood*; D001943:Breast Neoplasms / Q000276:immunology* / Q000473:pathology / Q000821:virology; D005260:Female; D006801:Humans; D015674:Mammary Neoplasms, Animal / Q000276:immunology* / Q000821:virology; D008324:Mammary Tumor Virus, Mouse / Q000276:immunology*; D051379:Mice; D009367:Neoplasm Staging
D000912:Antibodies, Neoplasm; D000914:Antibodies, Viral; D000957:Antigens, Viral, Tumor; D014408:Biomarkers, Tumor
Gumoral'nye antitela k strukturnym belkam virusa raka molochnykh zhelez mysheĭ (MMTV) kak vozmozhnyĭ immunologicheskiĭ marker raka molochnoĭ zhelezy cheloveka.