[Augmentin and Tiberal in elective colorectal surgery (comparison of serum and tissue levels and clinical results].
In a group of 340 patients subjected to colorectal surgery for antimicrobial prophylaxis amoxicillin clavulanate (Augmentin) or ornidazole (Tiberal) was used, in both instances as short-term monoprophylaxis. To test the effectiveness of prophylaxis, the clinical results were evaluated, expressed by the number of infectious complications, as well as serum and tissue levels of the two preparations used for prophylaxis. In serum and tissue they reached the MIC level of the tested microbial spectrum; an inadequate level was found in all probands in subcutaneous adipose tissue. The clinical result of 4.8% infectious complications when using ornidazole and 3.2% when using amoxicillin clavulante resp. is considered as evidence of the effectiveness and correct selection of preparations and also of sufficient short-term prophylaxis.
Hoch
J
J
Chirurgická klinika 2. LF UK.
Nyc
O
O
Jech
Z
Z
Lochmann
O
O
D000368:Aged; D000658:Amoxicillin / Q000493:pharmacokinetics / Q000627:therapeutic use; D019980:Amoxicillin-Potassium Clavulanate Combination; D002969:Clavulanic Acids / Q000493:pharmacokinetics / Q000627:therapeutic use; D003106:Colon / Q000601:surgery*; D004359:Drug Therapy, Combination / Q000493:pharmacokinetics / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009950:Ornidazole / Q000493:pharmacokinetics / Q000627:therapeutic use*; D011183:Postoperative Complications / Q000517:prevention & control; D011292:Premedication; D012007:Rectum / Q000601:surgery*
D002969:Clavulanic Acids; D009950:Ornidazole; D019980:Amoxicillin-Potassium Clavulanate Combination; D000658:Amoxicillin
Augmentin a Tiberal v elektivní kolorektální chirurgii (Srovnání sérových a tkánových hladin a klinických výsledků).