title: Nucleotide metabolism: mode of action of thiopurines in leukemia.
authors.affiliation: Department of Pediatrics, University Hospital Nijmegen, The Netherlands.
authors.forename: R A
authors.initials: RA
authors.lastname: De Abreu
mesh_terms: D000818:Animals; D000964:Antimetabolites, Antineoplastic / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D002470:Cell Survival / Q000187:drug effects; D004273:DNA, Neoplasm / Q000378:metabolism; D006801:Humans; D007938:Leukemia / Q000188:drug therapy* / Q000378:metabolism; D015122:Mercaptopurine / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D009711:Nucleotides / Q000378:metabolism*; D011687:Purines / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use*; D012334:RNA, Neoplasm / Q000378:metabolism; D013438:Sulfhydryl Compounds / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use
chemical_list: D000964:Antimetabolites, Antineoplastic; D004273:DNA, Neoplasm; D009711:Nucleotides; D011687:Purines; D012334:RNA, Neoplasm; D013438:Sulfhydryl Compounds; D015122:Mercaptopurine