title: Cytogenetic demonstration of gene amplification in a primary intracranial germ cell tumor.
abstract: We report the cytogenetic analysis of a primary pineal germinoma. The modal chromosome number was 81. Multiple numerical and structural chromosome abnormalities were noted along with a large homogeneously staining region (HSR). No isochromosome 12p was identified.
authors.affiliation: Department of Pathology (Neuropathology), Baylor College of Medicine, Houston, Texas 77030.
authors.forename: S
authors.initials: S
authors.lastname: Albrecht
authors.forename: D L
authors.initials: DL
authors.lastname: Armstrong
authors.forename: D H
authors.initials: DH
authors.lastname: Mahoney
authors.forename: W R
authors.initials: WR
authors.lastname: Cheek
authors.forename: L D
authors.initials: LD
authors.lastname: Cooley
mesh_terms: D000782:Aneuploidy; D001932:Brain Neoplasms / Q000235:genetics*; D002648:Child; D002869:Chromosome Aberrations; D004273:DNA, Neoplasm / Q000032:analysis*; D005784:Gene Amplification; D006801:Humans; D007621:Karyotyping; D008297:Male; D009364:Neoplasm Recurrence, Local; D009373:Neoplasms, Germ Cell and Embryonal / Q000235:genetics*; D010870:Pineal Gland; D011519:Proto-Oncogenes
chemical_list: D004273:DNA, Neoplasm