title: Neisseria meningitidis with decreased susceptibility to penicillin in Saskatchewan, Canada.
abstract: Moderately penicillin-resistant Neisseria meningitidis is rare in North America. We report an outbreak of meningococcal disease in Saskatoon, Saskatchewan, Canada, with serogroup C N. meningitidis. The MICs of penicillin ranged from 0.12 to 0.25 micrograms/ml, and all isolates showing decreased susceptibility had identical genomic fingerprints when they were compared by pulsed-field gel electrophoresis. Our data indicate that N. meningitidis that is moderately resistant to penicillin is prevalent in Saskatchewan, Canada.
authors.affiliation: Department of Clinical Microbiology, St. Paul's Hospital, Saskatoon, Ottawa, Canada.
authors.forename: J M
authors.initials: JM
authors.lastname: Blondeau
authors.forename: F E
authors.initials: FE
authors.lastname: Ashton
authors.forename: M
authors.initials: M
authors.lastname: Isaacson
authors.forename: Y
authors.initials: Y
authors.lastname: Yaschuck
authors.forename: C
authors.initials: C
authors.lastname: Anderson
authors.forename: G
authors.initials: G
authors.lastname: Ducasse
mesh_terms: D000293:Adolescent; D000328:Adult; D002648:Child; D002675:Child, Preschool; D016172:DNA Fingerprinting; D004269:DNA, Bacterial / Q000235:genetics / Q000302:isolation & purification; D004196:Disease Outbreaks; D016521:Electrophoresis, Gel, Pulsed-Field; D005260:Female; D006801:Humans; D007223:Infant; D008297:Male; D008585:Meningitis, Meningococcal / Q000188:drug therapy* / Q000453:epidemiology / Q000382:microbiology; D009345:Neisseria meningitidis / Q000145:classification / Q000187:drug effects* / Q000235:genetics; D010403:Penicillin Resistance; D012525:Saskatchewan / Q000453:epidemiology; D012703:Serotyping
chemical_list: D004269:DNA, Bacterial