title: Anorectic activity of NG-nitro-L-arginine, an inhibitor of brain nitric oxide synthase, in obese Zucker rats.
abstract: We investigated the effects of NG-nitro-L-arginine (L-NO Arg) administration (12.5, 25 and 50 mg/kg i.p.) on food consumption and body weight of male obese Zucker rats (fa/fa) and in their lean age-matched controls (FA/?; FA/FA), both groups aged 14 weeks. Acute or repeated administration of L-NO Arg reduced food intake and body weight in both obese and lean rats. However the lean rats showed tolerance to the L-NO Arg effects after 5 days of treatment. L-NO Arg anorexia was suppressed by pretreatment with metergoline. These results suggest that L-NO Arg may represent a new anorectic drug.
authors.affiliation: Institute of Pharmacology, School of Medicine, University of Messina, Italy.
authors.forename: F
authors.initials: F
authors.lastname: Squadrito
authors.forename: G
authors.initials: G
authors.lastname: Calapai
authors.forename: D
authors.initials: D
authors.lastname: Cucinotta
authors.forename: D
authors.initials: D
authors.lastname: Altavilla
authors.forename: B
authors.initials: B
authors.lastname: Zingarelli
authors.forename: M
authors.initials: M
authors.lastname: Ioculano
authors.forename: G
authors.initials: G
authors.lastname: Urna
authors.forename: A
authors.initials: A
authors.lastname: Sardella
authors.forename: G M
authors.initials: GM
authors.lastname: Campo
authors.forename: A P
authors.initials: AP
authors.lastname: Caputi
mesh_terms: D000594:Amino Acid Oxidoreductases / Q000037:antagonists & inhibitors*; D000818:Animals; D001067:Appetite Depressants / Q000494:pharmacology*; D001120:Arginine / Q000031:analogs & derivatives* / Q000494:pharmacology; D001835:Body Weight / Q000187:drug effects; D001921:Brain / Q000187:drug effects / Q000201:enzymology*; D004435:Eating / Q000187:drug effects; D008297:Male; D008711:Metergoline / Q000494:pharmacology; D019001:Nitric Oxide Synthase; D019335:Nitroarginine; D009765:Obesity / Q000201:enzymology*; D051381:Rats; D011924:Rats, Zucker; D016713:Ritanserin / Q000494:pharmacology; D012702:Serotonin Antagonists
chemical_list: D001067:Appetite Depressants; D012702:Serotonin Antagonists; D016713:Ritanserin; D008711:Metergoline; D019335:Nitroarginine; D001120:Arginine; D019001:Nitric Oxide Synthase; D000594:Amino Acid Oxidoreductases