title: [Treatment results of acute lymphoblastic leukemia in children from centers in Białostock and Szczecin].
abstract: The retrospective analysis was undertaken in order to assess treatment results of childhood ALL achieved in two "independent" units: in Białystok and Szczecin. It comprised 61 patients: 24 girls and 37 boys aged 10 - 197 months (median 64, mean 73 months), who between November 1987 and December 1992 were diagnosed as having ALL. 25 children, with risk factor greater than 0.8 were classified as intermediate risk patients. ALL 61 children were treated greater than 0.8 were classified as intermediate risk patients. ALL 61 children were treated according to BMF 86 protocol modification of the Polish Leukemia Study Group. The observation was closed in February 1993; the follow-up time was within the range of 10 - 72 months (median 32, mean 32 months). 7 patients (11.5%) did not enter remission, 4 children (6.6%) died in remission and 11 children (18.0%) relapsed. The probability of event-free survival (EFS) and disease-free survival (DFS) were 0.53 and 0.67 respectively. There was no statistical difference in p-EFS between standard and intermediate risk patients (SRG = 0.60 vs IRG = 0.53). It has been shown that p-EFS was not statistically influenced by age, sex, WBC, Hb level, paS-positive and acid-positive ALL. It has been suggested that protocol deviations were the main cause of the inferior (as compared to other domestic centers) treatment results.
authors.affiliation: I Kliniki Chorób Dzieci Katedry Chorób Dzieci PAM w Szczecinie.
authors.forename: J
authors.initials: J
authors.lastname: Peregud-Pogorzelski
authors.forename: T
authors.initials: T
authors.lastname: Urasiński
authors.forename: M
authors.initials: M
authors.lastname: Urban
authors.forename: I
authors.initials: I
authors.lastname: Krasowska
authors.forename: E
authors.initials: E
authors.lastname: Kamieńska
authors.forename: K
authors.initials: K
authors.lastname: Rosłan
authors.forename: A
authors.initials: A
authors.lastname: Brodkiewicz
mesh_terms: D000293:Adolescent; D002648:Child; D002675:Child, Preschool; D018572:Disease-Free Survival; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D007223:Infant; D008297:Male; D054198:Precursor Cell Lymphoblastic Leukemia-Lymphoma / Q000628:therapy*; D012189:Retrospective Studies; D012307:Risk Factors; D016896:Treatment Outcome
vernacular_title: Wyniki leczenia ostrej białaczki limfoblastycznej (OBL) u dzieci w ośrodkach białostockim i szczecińskim.