Effects of mitomycin C on delayed adjustment in experimental strabismus surgery.
In adjustable strabismus surgery, a satisfactory final result would be achieved with delayed adjustment. However, the postoperative adhesions following strabismus surgery make delayed adjustment impossible. We evaluated the efficacy of mitomycin C in reducing the severity of postoperative adhesions following strabismus surgery and in delaying the time adjustment after surgery. Experimental rabbits underwent a hang-back recession procedure in the superior rectus muscle. A topical application of mitomycin C was made between the conjunctiva and the sclera for 5 minutes during the operation. We then studied the possible time of delayed adjustment and estimated the minimal forces required for the adjustment. The topical application of 0.1 mg/ml mitomycin C between the conjunctiva and sclera allowed for a 2-week delayed adjustment after surgery, and 0.2 mg/ml mitomycin C prevented the adhesions between these tissues and the muscle 5 weeks after surgery. These results suggest that topical mitomycin C may enhance the success rate of strabismus surgery with delayed adjustment and reduce postoperative adhesions.
Oh
S O
SO
Department of Opthalmology, College of Medicine, Chungbuk National University, Cheongju, Korea.
Chang
B L
BL
Lee
J
J
D000287:Administration, Topical; D000818:Animals; D017024:Chemotherapy, Adjuvant; D003228:Conjunctiva / Q000187:drug effects; D016685:Mitomycin / Q000008:administration & dosage / Q000494:pharmacology*; D009801:Oculomotor Muscles / Q000187:drug effects / Q000473:pathology / Q000601:surgery*; D009883:Ophthalmic Solutions; D011183:Postoperative Complications / Q000517:prevention & control; D011817:Rabbits; D012590:Sclera / Q000187:drug effects; D013285:Strabismus / Q000188:drug therapy / Q000473:pathology / Q000601:surgery*; D013536:Suture Techniques; D000267:Tissue Adhesions / Q000517:prevention & control
D009883:Ophthalmic Solutions; D016685:Mitomycin