Radioprotective effect of vitamins C and E.
Albino rats were treated with aqueous vitamin C solution and vitamin E solution dissolved in olive oil at two concentrations, 100 and 300 mg/kg/day, for 6 months. Some of the animals were then subjected to whole-body irradiation. Chromosomal aberrations and mitotic activity in non-irradiated and irradiated groups were recorded. Both vitamins were found to be non-mutagenic. Vitamin C exerted a radioprotective effect but vitamin E was not radioprotective and it suppressed the radioprotection otherwise produced by olive oil.
el-Nahas
S M
SM
Cell Biology, National Research Centre, Dokki, Cairo, Egypt.
Mattar
F E
FE
Mohamed
A A
AA
D000818:Animals; D001205:Ascorbic Acid / Q000494:pharmacology*; D001853:Bone Marrow / Q000187:drug effects / Q000528:radiation effects; D002869:Chromosome Aberrations; D008297:Male; D009153:Mutagens / Q000633:toxicity; D011837:Radiation-Protective Agents / Q000494:pharmacology*; D051381:Rats; D014810:Vitamin E / Q000633:toxicity*; D014916:Whole-Body Irradiation
D009153:Mutagens; D011837:Radiation-Protective Agents; D014810:Vitamin E; D001205:Ascorbic Acid