title: Multicentric lymphoma involving large granular lymphocytes in a cow.
abstract: This case report describes for the first time in the literature a bovine multicentric lymphoma involving large granular lymphocytes (LGL). Clinically, the cow had typical manifestations of multicentric lymphoma with nonspecific signs. Most lymphocytes in cytological specimens from blood and lymph nodes had an LGL-morphology. Histopathologically malignant LGLs were found in the liver, kidneys, and lungs. The azurophilic granules were clearly seen with May-Grünwald-Giemsa stain. The granules were slightly eosinophilic as shown with hematoxylin-eosin stain, and most stained intensively dark with phosphotungstic acid hematoxylin.
authors.affiliation: Department of Pathological Anatomy, College of Veterinary Medicine, Helsinki, Finland.
authors.forename: S
authors.initials: S
authors.lastname: Saari
authors.forename: A K
authors.initials: AK
authors.lastname: Järvinen
mesh_terms: D000818:Animals; D002417:Cattle; D002418:Cattle Diseases / Q000473:pathology*; D005260:Female; D007668:Kidney / Q000473:pathology; D008099:Liver / Q000473:pathology; D008168:Lung / Q000473:pathology; D008198:Lymph Nodes / Q000473:pathology; D008214:Lymphocytes / Q000473:pathology* / Q000648:ultrastructure; D008223:Lymphoma / Q000473:pathology / Q000662:veterinary*