Chemoprevention of spontaneous tumorigenesis in p53-knockout mice.
Spontaneous tumorigenesis was evaluated in male p53-knockout (p53-/-) mice treated with dehydroepiandrosterone (DHEA), quercetin, d-limonene, or all-trans retinoic acid to determine whether tumor development in these mice can be modulated by cancer-chemopreventive agents. DHEA-treated mice experienced a delay in tumorigenesis (particularly lymphomas) and subsequent mortality (P < 0.01) relative to untreated control mice. Quercetin, d-limonene, and all-trans retinoic acid each had no effect on spontaneous tumor development in p53-/- mice. These data demonstrate that tumor development in p53-/- mice can be delayed by DHEA and suggest that p53-/- mice provide a useful model for evaluating strategies to offset the increased risk of tumorigenesis resulting from loss of p53 tumor suppressor function.
Hursting
S D
SD
Laboratory of Nutritional and Molecular Regulation, National Cancer Institute-Frederick Cancer Research and Development Center, Maryland 21702-1201, USA.
Perkins
S N
SN
Haines
D C
DC
Ward
J M
JM
Phang
J M
JM
D000818:Animals; D016588:Anticarcinogenic Agents / Q000627:therapeutic use*; D053138:Cyclohexenes; D003687:Dehydroepiandrosterone / Q000627:therapeutic use*; D017353:Gene Deletion; D016158:Genes, p53 / Q000502:physiology*; D000077222:Limonene; D008297:Male; D051379:Mice; D008810:Mice, Inbred C57BL; D009369:Neoplasms / Q000235:genetics / Q000517:prevention & control*; D011794:Quercetin / Q000627:therapeutic use; D013729:Terpenes / Q000627:therapeutic use; D014212:Tretinoin / Q000627:therapeutic use
D016588:Anticarcinogenic Agents; D053138:Cyclohexenes; D013729:Terpenes; D003687:Dehydroepiandrosterone; D014212:Tretinoin; D011794:Quercetin; D000077222:Limonene