New frontiers in myocardial protection: harnessing the heart's endogenous protective systems.
Researchers have continued to search for therapeutic agents to protect the heart during ischemia and reperfusion. Recent studies have suggested that harnessing the heart's endogenous systems for self-preservation may provide improved protection from ischemic injury. Two such phenomena, preconditioning and heat-shock protein synthesis, have been shown to uniformly reduce myocardial damage. This review highlights the newest research in myocardial protective strategies and suggests avenues of future investigation.
Engelman
D T
DT
Surgical Research Center, University of Connecticut School of Medicine, Farmington, USA.
D000222:Adaptation, Physiological; D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology* / Q000517:prevention & control*; D013312:Stress, Physiological / Q000503:physiopathology
D006360:Heat-Shock Proteins; D000255:Adenosine Triphosphate