[The effects of glucocorticoid on rabbit polymorphonuclears during inflammation].
The CD18 expression on rabbit polymorphonuclears (PMNs) and adhesion rate of rabbit PMNs to ICAM-1 coated magnetic beads were determined, and the correlationship was analysed between CD18 expression and adhesion rate. The results showed that glucocorticoid inhibited the rise of CD18 expression on rabbit PMNs caused by tumor necrosis factor (TNF) and that the inhibitory effect reversed when glucocorticoid receptor (GR) was blocked by RU 38486. There was a positive correlationship (r = 0.966) after PMNs were cultured with a range concentration of dexamethasone (Dex). The data indicate that GC inhibits the rise of CD18 expression on rabbit PMNs caused by TNF which is mediated by GR, and plays an important role in inhibition of PMNs adhesion.
Chen
J
J
Department of Pathophysiology, Second Military Medical University, Shanghai.
Gong
X
X
Zhong
J
J
D000818:Animals; D018821:CD18 Antigens / Q000378:metabolism; D002448:Cell Adhesion / Q000187:drug effects; D003907:Dexamethasone / Q000494:pharmacology*; D007249:Inflammation / Q000276:immunology*; D018799:Intercellular Adhesion Molecule-1; D008297:Male; D009504:Neutrophils / Q000276:immunology*; D011817:Rabbits
D018821:CD18 Antigens; D018799:Intercellular Adhesion Molecule-1; D003907:Dexamethasone