title: Lipid-mediated a-factor interactions with artificial membranes.
abstract: Our understanding of the cellular export of a-factor and its interaction with the receptor do not yet allow for a description of the phenomena on a molecular level. Synthesis of a-factor analogs and biophysical studies of the lipopeptides in the presence of artificial membranes provide insights which can be analyzed with respect to the biological potency of the molecules. It is through the study of the interaction of the lipopeptides with membranes at varying levels of complexity that we will be able to develop a molecular description of the biological processes.
authors.affiliation: Department of Biochemistry, McMaster University Health Sciences Center, Hamilton, Ontario, Canada.
authors.forename: R M
authors.initials: RM
authors.lastname: Epand
authors.forename: F
authors.initials: F
authors.lastname: Naider
authors.forename: J M
authors.initials: JM
authors.lastname: Becker
mesh_terms: D019883:Alkyl and Aryl Transferases; D000595:Amino Acid Sequence; D005204:Farnesol; D051231:Farnesyltranstransferase; D007202:Indicators and Reagents; D008051:Lipid Bilayers; D000072235:Mating Factor; D008969:Molecular Sequence Data; D010455:Peptides / Q000138:chemical synthesis / Q000737:chemistry* / Q000378:metabolism; D010675:Pheromones / Q000737:chemistry; D011106:Polyisoprenyl Phosphates / Q000378:metabolism; D017368:Protein Prenylation; D011995:Recombination, Genetic; D012441:Saccharomyces cerevisiae / Q000502:physiology*; D012717:Sesquiterpenes; D013045:Species Specificity; D014166:Transferases / Q000378:metabolism
chemical_list: D007202:Indicators and Reagents; D008051:Lipid Bilayers; D010455:Peptides; D010675:Pheromones; D011106:Polyisoprenyl Phosphates; D012717:Sesquiterpenes; D005204:Farnesol; D000072235:Mating Factor; C004808:farnesyl pyrophosphate; D014166:Transferases; D019883:Alkyl and Aryl Transferases; D051231:Farnesyltranstransferase