title: A translating-bed technique for total-body irradiation.
abstract: Total-body irradiation (TBI) is a therapy modality that is being used with increasing frequency, in conjunction with chemotherapy, for patients undergoing bone-marrow transplantation. At the Ottawa Regional Cancer Centre a technique has been developed for the delivery of TBI to patients prior to bone-marrow transplantation. In this technique patients are treated on a mobile couch at approximately 195 cm SSD with a field size of 66.5 cm wide by 57 cm long. A computer-controlled stepping motor drives the patient couch at a user-selectable speed. The total dose delivered to the patient is a function of couch velocity, field size and patient separation. Treatment times are of the order of 10 min for each of the anterior and posterior fields for a 400 cGy fraction. It has been found that the conventional central axis tissue maximum ratio (TMR) and percentage depth dose (PDD) functions are not appropriate for describing dose delivered during dynamic treatment. To this end we have developed dynamic TMR and PDD functions. Extensive measurements have been performed in an anthropomorphic water phantom to determine the dose distributions in three dimensions and the efficacy of polymethyl methacrylate (PMMA) beam spoilers as a replacement for anterior and lateral bolus. It has been found that 2.4 cm PMMA spoilers do provide full skin dose and negate the requirement for lateral bolus. This TBI procedure is simple, rapid and appears to be well tolerated by the patients. 55 patients have been treated since the introduction of this technique in 1991.
authors.affiliation: Ottawa Regional Cancer Centre, Ontario, Canada.
authors.forename: L H
authors.initials: LH
authors.lastname: Gerig
authors.forename: J
authors.initials: J
authors.lastname: Szanto
authors.forename: T
authors.initials: T
authors.lastname: Bichay
authors.forename: P
authors.initials: P
authors.lastname: Genest
mesh_terms: D016026:Bone Marrow Transplantation / Q000276:immunology; D006801:Humans; D007165:Immunosuppression Therapy / Q000379:methods; D007166:Immunosuppressive Agents; D008433:Mathematics; D008961:Models, Structural; D011879:Radiotherapy Dosage; D011881:Radiotherapy, Computer-Assisted / Q000295:instrumentation / Q000379:methods*; D014916:Whole-Body Irradiation / Q000295:instrumentation / Q000379:methods*
chemical_list: D007166:Immunosuppressive Agents