Transmission of cervical human papillomavirus infection by sexual activity: differences between low and high oncogenic risk types.
Not all studies have proven that cervical human papillomavirus (HPV) infection is a sexually acquired condition. Determinants of HPV infection were analyzed in a survey of 718 asymptomatic women in northeastern Brazil. HPV DNA was detected and typed by polymerase chain reaction. HPV types were classified into low- and high-risk groups on the basis of their association with cervical carcinomas. Overall HPV prevalence (18.3%) was moderately associated with age at first intercourse (P = .111, trend) and number of lifetime sex partners (P = .005, trend). However, separate analyses by risk revealed different degrees of association with sexual activity. Except for a positive association with multiple partners among women < 40 years old (P = .034, trend), infection with low-risk types (9.7%) was not correlated with sexual behavior. On the other hand, infection with high-risk HPV types (11.6%) was strongly and independently associated with both multiple partners (P = .009, trend) and age at first intercourse (P = .007, trend) in all age groups.
Franco
E L
EL
Department of Epidemiology, Institut Armand-Frappier, Montreal, Canada.
Villa
L L
LL
Ruiz
A
A
Costa
M C
MC
D000328:Adult; D000367:Age Factors; D000368:Aged; D004279:DNA, Viral / Q000032:analysis*; D005260:Female; D006801:Humans; D007407:Interviews as Topic; D008297:Male; D008875:Middle Aged; D016017:Odds Ratio; D027383:Papillomaviridae / Q000302:isolation & purification; D030361:Papillomavirus Infections / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D012307:Risk Factors; D012725:Sexual Behavior; D012749:Sexually Transmitted Diseases / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D014412:Tumor Virus Infections / Q000453:epidemiology / Q000635:transmission* / Q000821:virology; D002577:Uterine Cervical Diseases / Q000821:virology*
D004279:DNA, Viral