Do silicone breast implants cause autoimmune rheumatic diseases?
Current estimates are that up to a million women in the U.S. have breast implants with the predominant type being the silicone gel implant. Concerns have been raised regarding the safety of silicone gel breast implants with focus upon whether escaped gel might cause inflammatory and immune responses that subsequently lead to autoimmune rheumatic diseases such as progressive systemic sclerosis (scleroderma), systemic lupus erythematosus (SLE), Sjögren's syndrome or rheumatoid arthritis. A spectrum of illnesses ranging from local symptoms to systemic disease is seen in some patients with silicone breast implants, however, it remains to be determined whether such illnesses in these patients are coincidentally associated or are secondary to the implants. Our understanding of the relationship between the presence of autoimmune rheumatic diseases and silicone breast implants is limited. The available data indicate that silicone elicits a minimal immunological response as compared to conventional antigens. The histological, immunological and epidemiological experimental data derived from patients with silicone implants, as well as those from animal studies, are reviewed. These data do not convincingly demonstrate that there is a cause and effect relationship between silicone breast implants and autoimmune diseases. Further investigations are needed to clarify the interaction of silicone with the cellular and humoral immune systems, as well as with host and environmental factors.
Smith
H R
HR
Department of Medicine, Meridia Huron Hospital, Case Western Reserve University, Cleveland, OH 44112, USA.
D000974:Antibodies, Antinuclear / Q000276:immunology; D001172:Arthritis, Rheumatoid / Q000139:chemically induced; D001327:Autoimmune Diseases / Q000139:chemically induced* / Q000473:pathology; D018427:Breast Implants / Q000009:adverse effects* / Q000592:standards / Q000639:trends; D005260:Female; D006801:Humans; D008180:Lupus Erythematosus, Systemic / Q000139:chemically induced; D012216:Rheumatic Diseases / Q000139:chemically induced* / Q000473:pathology; D012595:Scleroderma, Systemic / Q000139:chemically induced; D012828:Silicones / Q000009:adverse effects*; D012859:Sjogren's Syndrome / Q000139:chemically induced
D000974:Antibodies, Antinuclear; D012828:Silicones