title: [Features of transport function and structure of serum albumin in cancer].
abstract: Levels of lipid ligands in serum albumin from cancer patients were assayed versus tumor localization. Abnormal non-specific increase in albumin-bound lipids as well as in peroxidation products was found. Gas-liquid chromatography of different polynonsaturated fatty acids pointed to the enhancement of their metabolism via the omega 3 pathway. The despiralization-type changes in secondary structure of albumin identified by procedures of spectral analysis and the decline in reserve functional activity of protein in tumor patients were matched by a rise in levels of serum albumin-transported ligands. It is suggested that such increase in the ligand-binding ability of albumin provides a major adaptive factor involved in oncopatology.
authors.forename: N V
authors.initials: NV
authors.lastname: Tolkacheva
authors.forename: S N
authors.initials: SN
authors.lastname: Borisenko
authors.forename: S N
authors.initials: SN
authors.lastname: Kulakova
authors.forename: M M
authors.initials: MM
authors.lastname: Levachev
authors.forename: I N
authors.initials: IN
authors.lastname: Onsovich
mesh_terms: D001692:Biological Transport; D016022:Case-Control Studies; D002851:Chromatography, High Pressure Liquid; D006801:Humans; D050356:Lipid Metabolism; D015227:Lipid Peroxidation / Q000502:physiology; D009369:Neoplasms / Q000097:blood*; D012709:Serum Albumin / Q000378:metabolism*
chemical_list: D012709:Serum Albumin
vernacular_title: Kharakteristika transportnoĭ funktsii i struktury syvorotochnogo al'bumina u onkologicheskikh bol'nykh.