[The effect of retinoic acid on cell membrane and metastatic ability of mouse forestomach carcinoma cells].
We studied the effect of all-trans-retinoic acid (RA) on the expression of several surface lectin receptors and cell membrane fluidity of mouse forestomach carcinoma cell line (MFC) in vitro. The results showed that cells treated with RA manifested decreased expression of lectin receptors, increased membrane fludity and reduced spontanous metastasis. These rusults suggest that the effect of RA on tumor cell membrane may be one of the mechanisms involved in the alternation of cell metastatic phenotype.
Yu
X
X
Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Beijing.
Zhao
X
X
Gao
J
J
D000818:Animals; D008175:Lung Neoplasms / Q000556:secondary*; D008297:Male; D008560:Membrane Fluidity / Q000187:drug effects*; D051379:Mice; D008815:Mice, Inbred Strains; D009368:Neoplasm Transplantation; D009374:Neoplasms, Experimental / Q000473:pathology*; D011975:Receptors, Mitogen / Q000378:metabolism; D014212:Tretinoin / Q000494:pharmacology*; D014407:Tumor Cells, Cultured
D011975:Receptors, Mitogen; D014212:Tretinoin