[A preliminary study on the antenatal diagnosis and prevention of the fetus toxoplasmosis infection].
For those pregnant women with an abnormal pregnancy history, the polymerase chain reaction (PCR) technique was adopted to screening the serum toxoplasmosis DNA (TOX-DNA). Then tests were made for further evidence of TOX-DNA in the amnionic fluids TOX-DNA was examined in cases with blood TOX-DNA positive. Gamma glutamyl transpeptidase (GGT) and alpha-fetoprotein (AFP) in the amnionic fluids were measured for reference, a antenatal diagnosis of the fetal congenital toxoplasmosis infection could thus be made. In the present paper, 9 out of 92 blood specimen were TOX-DNA positive, of the 9 cases, 5 had TOX-DNA and 4 had no TOX-DNA in the amnionic fluid tests. The results of follow-up examination in the 9 cases were in conformity with the ante natal diagnosis. This is an important procedure for diagnosis and prevention of maternal-fetal vertical infection of Toxoplasmosis.
Li
S
S
People's Hospital of Panyu City, Guangdong.
Ding
Z
Z
Liang
Y
Y
D000818:Animals; D016054:DNA, Protozoan / Q000097:blood*; D005260:Female; D005315:Fetal Diseases / Q000175:diagnosis*; D006801:Humans; D018445:Infectious Disease Transmission, Vertical / Q000517:prevention & control*; D016133:Polymerase Chain Reaction; D011247:Pregnancy; D015597:Pregnancy Complications, Parasitic / Q000469:parasitology; D011296:Prenatal Diagnosis; D014122:Toxoplasma / Q000302:isolation & purification; D014123:Toxoplasmosis / Q000635:transmission*; D014125:Toxoplasmosis, Congenital / Q000175:diagnosis* / Q000196:embryology
D016054:DNA, Protozoan