Platelet-activating factor. Role in fetal lung development and relationship to normal and premature labor.
In this overview on the role of PAF in reproductive biology, we have emphasized its relationship to fetal lung maturation and the initiation and maintenance of parturition. In addition, we have discussed the role of this autacoid in certain complications of premature delivery. It should be pointed out, however, that it is our view that other mediators and cytokines also play a role in these processes. In the past, many investigators have suggested a central role for one of these mediators that serves as the "trigger" of these biologic events. It is our view that these systems are regulated by a number of effectors, among which PAF may play an important role.
Toyoshima
K
K
Department of Obstetrics-Gynecology, Keio University, Tokyo, Japan.
Narahara
H
H
Furukawa
M
M
Frenkel
R A
RA
Johnston
J M
JM
D016207:Cytokines / Q000502:physiology; D005314:Embryonic and Fetal Development; D005260:Female; D005325:Fetal Organ Maturity; D006801:Humans; D018836:Inflammation Mediators / Q000494:pharmacology; D007743:Labor, Obstetric / Q000502:physiology*; D008168:Lung / Q000196:embryology*; D007752:Obstetric Labor, Premature / Q000503:physiopathology*; D010972:Platelet Activating Factor / Q000502:physiology*; D011247:Pregnancy
D016207:Cytokines; D018836:Inflammation Mediators; D010972:Platelet Activating Factor