Effect of 2-amino-4-phosphonobutyrate on ERG OFF-response after glycinergic and GABAergic blockade.
Superfusion with 200 microM 2-amino-4-phosphonobutyrate (APB) of dark and chromatically adapted frog eyecups caused marked potentiation of the ERG OFF-response (d-wave). Blockade of the glycinergic synapses by strychnine did not change this effect at all. Blockade of the GABAergic synapses by picrotoxin slightly diminished the effect of APB in chromatically-adapted eyes with isolated cones' activity, and did not change it in dark-adapted eyes. The results indicate that the action of APB on ERG OFF-response does not depend significantly on GABAergic and glycinergic neurotransmission in frog retina.
Popova
E
E
Department of Physiology, Medical Faculty, Sofia, Bulgaria.
Kupenova
P
P
Vitanova
L
L
Mitova
L
L
D000221:Adaptation, Ocular / Q000187:drug effects; D000613:Aminobutyrates / Q000494:pharmacology*; D000818:Animals; D003116:Color; D003623:Dark Adaptation / Q000187:drug effects; D005998:Glycine / Q000378:metabolism; D066298:In Vitro Techniques; D010852:Picrotoxin / Q000494:pharmacology; D011895:Rana ridibunda; D012160:Retina / Q000187:drug effects*; D013331:Strychnine / Q000494:pharmacology; D013569:Synapses / Q000187:drug effects; D009435:Synaptic Transmission / Q000187:drug effects; D013997:Time Factors; D005680:gamma-Aminobutyric Acid / Q000378:metabolism
D000613:Aminobutyrates; D005998:Glycine; D010852:Picrotoxin; D013331:Strychnine; D005680:gamma-Aminobutyric Acid; C012729:2-amino-4-phosphonobutyric acid