title: The estimation of local brain temperature by in vivo 1H magnetic resonance spectroscopy.
abstract: Brain temperature may be important for investigating pathology and cerebroprotective effects of pharmaceuticals and hypothermia. Two methods for estimating temperature using 1H magnetic resonance spectroscopy are described: a partially water-suppressed binomial sequence and non-water-suppressed point-resolved spectroscopy. Relative to N-acetylaspartate (Naa), water chemical shift (delta H2O-Naa) in piglet brain depended linearly on temperature from 30 degrees to 40 degrees C: temperature was 286.9-94.0 delta H2O-Naa degrees C. Thalamic temperature in six normal infants was 38.1 degrees +/- 0.4 degree C indicating that local brain temperature could be estimated with adequate sensitivity for studying pathologic and therapeutic changes.
authors.affiliation: Department of Medical Physics and Bio-Engineering, University College London Hospitals NHS Trust, England.
authors.forename: E B
authors.initials: EB
authors.lastname: Cady
authors.forename: P C
authors.initials: PC
authors.lastname: D'Souza
authors.forename: J
authors.initials: J
authors.lastname: Penrice
authors.forename: A
authors.initials: A
authors.lastname: Lorek
mesh_terms: D000818:Animals; D000831:Animals, Newborn; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001831:Body Temperature; D001921:Brain / Q000502:physiology*; D001923:Brain Chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013552:Swine
chemical_list: D001224:Aspartic Acid; C000179:N-acetylaspartate