Cromakalim suppresses hypertonic saline-induced renal vasoconstriction in anaesthetized dogs.
1. Intrarenal arterial infusion of hypertonic saline (HS) transiently increased and then gradually reduced renal blood flow (RBF) in anaesthetized dogs. Glomerular filtration rate (GFR) but not filtration fraction decreased at the end of the infusion. 2. In the presence of a potassium channel opener cromakalim (0.3 microgram/kg per min), HS infusion failed to reduce RBF; the initial increase in RBF was maintained throughout the infusion. Since cromakalim also prevented the decrease in GFR, HS infusion lowered filtration fraction. 3. The results suggest that cromakalim inhibits both pre-and postglomerular vasoconstriction induced by HS infusion.
Ogasawara
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Department of Pharmacology, Tohoku University, Sendai, Japan.
Hirano
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Hisa
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Satoh
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S
D000818:Animals; D001578:Benzopyrans / Q000494:pharmacology*; D019806:Cromakalim; D004195:Disease Models, Animal; D004231:Diuresis / Q000187:drug effects; D004285:Dogs; D005260:Female; D005919:Glomerular Filtration Rate / Q000187:drug effects; D006400:Hematocrit; D008297:Male; D015221:Potassium Channels / Q000187:drug effects; D011758:Pyrroles / Q000494:pharmacology*; D012079:Renal Circulation / Q000187:drug effects; D012462:Saline Solution, Hypertonic / Q000633:toxicity; D012964:Sodium / Q000652:urine; D014661:Vasoconstriction / Q000187:drug effects*; D014665:Vasodilator Agents / Q000494:pharmacology*
D001578:Benzopyrans; D015221:Potassium Channels; D011758:Pyrroles; D012462:Saline Solution, Hypertonic; D014665:Vasodilator Agents; D019806:Cromakalim; D012964:Sodium