[Familial occurrence of cluster headache].
The familial occurrence of cluster headache was assessed in 421 probands with cluster headache, diagnosed according to the diagnostic criteria of the International Headache Society. The probands were from a neurological clinic and two departments of neurology. They received a mailed questionnaire regarding the presence of cluster headache among their relatives. All possibly affected relatives were interviewed by telephone. The questionnaire response rate was 88% (370/421). Seven probands belonged to three families. Familial occurrence of cluster headache was confirmed in 7% (25/366) of the families. Compared with the general population, first degree relatives of probands with cluster headache had a 14-fold increased risk of cluster headache, after standardization for sex and age. The second degree relatives had a twofold increased risk of cluster headache. The increased familial risk of cluster headache strongly suggests that cluster headache has a genetic cause.
Russell
M B
MB
Neurologisk afdeling, Amtssygehuset i Glostrup.
Andersson
P G
PG
Thomsen
L L
LL
D000328:Adult; D000368:Aged; D003027:Cluster Headache / Q000453:epidemiology / Q000235:genetics*; D003718:Denmark / Q000453:epidemiology; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D012307:Risk Factors; D011795:Surveys and Questionnaires
Familiaer forekomst af klyngehovedpine.