[Combination of the deportalization of pancreatic blood flow and transplantation of pancreatic islets in patients with insulin dependent diabetes mellitus].
In 137 patients with insulin dependent diabetes mellitus (74 men and 63 women) aged from 16 to 60 years 193 operations were done, including 148 xenografts of cryopreserved cells of pancreatic islets and 45 deportalizations of pancreatic blood flow using the distal venous splenorenal anastomosis formation. Pronounced antidiabetic effect of both operations was observed, justified by metabolic compensation of diabetes mellitus, lowering of given insulin dose, stabilization of chronic diabetic microangiopathy and polyneuropathy course. Complex approach to the surgical treatment of diabetes mellitus comprises the performance of repeated or multiple transplantations of pancreatic islets cells as well as (what is more expedient) its gradual application in combination with the pancreatic blood flow deportalization. Stationary and regional banks of cryopreserved cells of pancreatic islets were founded.
Nikonenko
A S
AS
Kovalev
A A
AA
Zavgorodniĭ
S N
SN
Volkova
N A
NA
D000293:Adolescent; D000328:Adult; D000818:Animals; D015925:Cryopreservation; D003921:Diabetes Mellitus, Experimental / Q000601:surgery; D003922:Diabetes Mellitus, Type 1 / Q000601:surgery*; D005260:Female; D005333:Fetus; D006801:Humans; D007515:Islets of Langerhans; D016381:Islets of Langerhans Transplantation; D008297:Male; D008875:Middle Aged; D009926:Organ Preservation; D051381:Rats; D017208:Rats, Wistar; D013164:Splenorenal Shunt, Surgical; D013311:Streptozocin; D014183:Transplantation, Heterologous
D013311:Streptozocin
Sochetannoe primenenie deportalizatsii krovotoka podzheludochnoĭ zhelezy i transplantatsii kriokonservirovannykh kletok pankreaticheskikh ostrovkov u bol'nykh s insulinzavisimym sakharnym diabetom.