title: A comparison of orocaecal transit times assessed by the breath hydrogen test and the sulphasalazine/sulphapyridine method in healthy beagle dogs.
abstract: Orocaecal transit time (OCTT) was assessed in six healthy beagles by means of the breath hydrogen test (BH2T) and the sulphasalazine/sulphapyridine method (SLZ) after the administration of a test meal of canned food mixed with sulphasalazine. Orocaecal transit time was defined as the time taken from the oral administration of the test meal to the time when the first portion of the meal reached the colon. In five of the dogs the OCTTs assessed by the BH2T were shorter than those measured by the SLZ method by 30, 15, 45, 30 and 45 minutes. However, the median OCTT assessed by the BH2T (135 minutes, range 120 to 195 minutes) was not significantly different from that measured by the SLZ (180 minutes, range 150 to 210 minutes) and was highly correlated with it (r = 0.94, P = 0.016). The sixth dog maintained baseline hydrogen and plasma sulphapyridine readings throughout the monitoring period and the OCTT could not be measured.
authors.forename: K
authors.initials: K
authors.lastname: Papasouliotis
authors.forename: T J
authors.initials: TJ
authors.lastname: Gruffydd-Jones
authors.forename: A H
authors.initials: AH
authors.lastname: Sparkes
authors.forename: P J
authors.initials: PJ
authors.lastname: Cripps
mesh_terms: D000818:Animals; D001944:Breath Tests; D004285:Dogs / Q000502:physiology*; D005772:Gastrointestinal Transit / Q000502:physiology*; D006859:Hydrogen / Q000032:analysis*; D008297:Male; D013427:Sulfapyridine / Q000097:blood / Q000493:pharmacokinetics*; D012460:Sulfasalazine / Q000493:pharmacokinetics*; D013997:Time Factors
chemical_list: D012460:Sulfasalazine; D006859:Hydrogen; D013427:Sulfapyridine