[Anemia in puerperium; parenteral iron substitution renders erythropoietin therapy dispensable].
In a double-blind, randomised study we treated 36 women in the puerperium with haemoglobin concentration below 9 g/dl with 400 mg Fe . 20 women received 20,000 IE erythropoietin (rHuEPO) i.v. in addition, 12 women received placebos. In both groups there were no differences in the haematological and iron parameters in the first 4 weeks after delivery. The results show that the additional therapy with rHuEPO in postpartum anaemia is not justified. The limiting factor in a quick correction of the postpartum anaemia is the insufficient presence of iron at the end of pregnancy. The therapy of choice for quick and safe correction of p.p. anaemia is the effective intravenous iron supplementation.
Lebrecht
A
A
Frauenklinik des Thurgauischen Kantonsspitals Frauenfeld.
Häberlin
F
F
Eberhard
J
J
D018798:Anemia, Iron-Deficiency / Q000097:blood / Q000188:drug therapy*; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D004906:Erythrocyte Count / Q000187:drug effects; D004921:Erythropoietin / Q000008:administration & dosage* / Q000009:adverse effects; D005260:Female; D005293:Ferritins / Q000378:metabolism; D006400:Hematocrit; D006452:Hemoglobinometry; D006801:Humans; D007262:Infusions, Intravenous; D007501:Iron / Q000008:administration & dosage*; D011446:Prospective Studies; D011644:Puerperal Disorders / Q000097:blood / Q000188:drug therapy*; D011994:Recombinant Proteins / Q000008:administration & dosage / Q000009:adverse effects
D011994:Recombinant Proteins; D004921:Erythropoietin; D005293:Ferritins; D007501:Iron
Anämie im Wochenbett; parenterale Eisensubstitution macht Erythropoetin-Therapie entbehrlich.