title: The porcine intestinal receptor for Escherichia coli K88ab, K88ac: regional localization on chromosome 13 and influence of IgG response to the K88 antigen.
abstract: The loci encoding the porcine intestinal receptors for Escherichia coli K88ab and K88ac (K88abR and K88acR) were firmly assigned to chromosome 13 by linkage analysis using a three-generation pedigree. The linear order of these loci and seven other markers on chromosome 13 was determined by multipoint analyses. The K88abR and K88acR loci were tightly linked (theta = 0.01, zeta = 41.06) with the K88abR locus localized 7.4 cM (sex average) proximal to the transferrin locus. The results, together with previous reports from two other groups, provide an unequivocal assignment of the K88 receptor loci to chromosome 13, and reject a previous assignment to chromosome 4. Pigs possessing the receptor had a slightly higher specific IgG response to the K88 antigen after an intramuscular immunization with an E. coli vaccine.
authors.affiliation: Department of Animal Breeding and Genetics, Swedish University of Agricultural Sciences, Uppsala.
authors.forename: I
authors.initials: I
authors.lastname: Edfors-Lilja
authors.forename: U
authors.initials: U
authors.lastname: Gustafsson
authors.forename: Y
authors.initials: Y
authors.lastname: Duval-Iflah
authors.forename: H
authors.initials: H
authors.lastname: Ellergren
authors.forename: M
authors.initials: M
authors.lastname: Johansson
authors.forename: R K
authors.initials: RK
authors.lastname: Juneja
authors.forename: L
authors.initials: L
authors.lastname: Marklund
authors.forename: L
authors.initials: L
authors.lastname: Andersson
mesh_terms: D000818:Animals; D000907:Antibodies, Bacterial / Q000096:biosynthesis; D000942:Antigens, Bacterial / Q000378:metabolism*; D000954:Antigens, Surface / Q000378:metabolism*; D001422:Bacterial Adhesion; D002874:Chromosome Mapping; D004926:Escherichia coli / Q000276:immunology*; D029968:Escherichia coli Proteins; D005260:Female; D036781:Fimbriae Proteins; D008040:Genetic Linkage; D007074:Immunoglobulin G / Q000096:biosynthesis; D007422:Intestines / Q000382:microbiology; D008297:Male; D011956:Receptors, Cell Surface / Q000235:genetics*; D013552:Swine / Q000235:genetics* / Q000276:immunology / Q000382:microbiology
chemical_list: D000907:Antibodies, Bacterial; D000942:Antigens, Bacterial; D000954:Antigens, Surface; D029968:Escherichia coli Proteins; D007074:Immunoglobulin G; C026888:K88 antigen, E coli; D011956:Receptors, Cell Surface; D036781:Fimbriae Proteins