title: [Antigenicity study of T-3761].
abstract: Antigenicity studies of T-3761, a new quinolone derivative, were conducted and the following results were obtained. 1. By active systemic anaphylaxis test in guinea pigs, neither immunogenicity nor allergenicity of T-3761 was noted. 2. By homologous 4-hour passive cutaneous anaphylaxis (PCA) test using the serum obtained from these guinea pigs, neither immunogenicity nor allergenicity of T-3761 was noted. 3. The potential of IgE antibody production in mice was examined by heterologous 24-hour PCA test in rats. But neither the potential of IgE antibody production nor allergenicity of T-3761 was noted. 4. By passive hemagglutination assay, we analysed the antibody titer in rats and dogs serum obtained from three-month toxicity repeated dose studies (oral and intravenously administration). But the hemagglutination response was negative and specific antibodies were not detected.
authors.affiliation: Research Laboratories, Toyama Chemical Co., Ltd., Japan.
authors.forename: T
authors.initials: T
authors.lastname: Shibata
authors.forename: N
authors.initials: N
authors.lastname: Iwai
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
authors.forename: Y
authors.initials: Y
authors.lastname: Kawamura
authors.forename: T
authors.initials: T
authors.lastname: Kodama
mesh_terms: D000707:Anaphylaxis; D000818:Animals; D000890:Anti-Infective Agents / Q000008:administration & dosage / Q000276:immunology*; D004285:Dogs; D024841:Fluoroquinolones; D006168:Guinea Pigs; D006386:Hemagglutination Tests; D007073:Immunoglobulin E / Q000032:analysis / Q000096:biosynthesis; D008297:Male; D051379:Mice; D008807:Mice, Inbred BALB C; D010078:Oxazines / Q000008:administration & dosage / Q000276:immunology*; D010323:Passive Cutaneous Anaphylaxis; D051381:Rats
chemical_list: D000890:Anti-Infective Agents; D024841:Fluoroquinolones; D010078:Oxazines; D007073:Immunoglobulin E; C078052:pazufloxacin