title: Adenovirus infections in human immunodeficiency virus-positive patients: clinical features and molecular epidemiology.
abstract: Prospective surveillance of 63 human immunodeficiency virus (HIV)-positive patients and 9 HIV-negative partners over 5-27 months yielded 51 adenoviruses from 18 HIV-positive patients. These were serotyped and compared by restriction enzyme analysis (REA) together with 24 isolates from 19 other HIV-positive patients. The actuarial risk of infection at 1 year in HIV-positive patients was 28% (17% with entry CD4 cell count of > 200/mm3 and 38% with CD4 cell count of < or = 200/mm3, P = .03). The most frequent site of infection was gastrointestinal (17/18 patients) with mainly subgenus D adenoviruses, while urinary infection was caused by subgenus B or D. Prolonged fecal excretion (2-27 months) was associated with CD4 cell counts < 150/mm3. Identical strains were seen in 2 HIV-positive partners and 2 unrelated patients. Gastrointestinal infection was temporally associated with diarrhea in only 7 (41%) of 17 cases. The remainder (59%) were asymptomatic or minimally symptomatic, and diarrhea was often caused by other opportunistic pathogens.
authors.affiliation: Department of Infectious Diseases, Monsall Unit, North Manchester General Hospital, United Kingdom.
authors.forename: S H
authors.initials: SH
authors.lastname: Khoo
authors.forename: A S
authors.initials: AS
authors.lastname: Bailey
authors.forename: J C
authors.initials: JC
authors.lastname: de Jong
authors.forename: B K
authors.initials: BK
authors.lastname: Mandal
mesh_terms: D000386:AIDS-Related Complex / Q000503:physiopathology; D017088:AIDS-Related Opportunistic Infections / Q000453:epidemiology*; D000163:Acquired Immunodeficiency Syndrome / Q000503:physiopathology*; D000206:Actuarial Analysis; D000258:Adenovirus Infections, Human / Q000453:epidemiology*; D000260:Adenoviruses, Human / Q000145:classification / Q000235:genetics / Q000302:isolation & purification*; D000328:Adult; D016022:Case-Control Studies; D005260:Female; D018023:HIV Seronegativity; D006679:HIV Seropositivity / Q000150:complications*; D006801:Humans; D008137:Longitudinal Studies; D008297:Male; D000091402:Prohibitins; D015183:Restriction Mapping; D012307:Risk Factors; D012703:Serotyping