Mature teratoma of the uterine cervix with pulmonary differentiation.
Teratomas of the uterus are very rare, and a uterine teratoma with pulmonary differentiation has not, to our knowledge, been described previously. In this article, we report such a case in a 33-year-old woman, who presented with heavy vaginal bleeding and a polypoid mass of the uterine cervix. The cervical lesion was composed entirely of mature lung tissue, including bronchial, bronchiolar, and alveolar structures. The presence of well-differentiated respiratory epithelial cells, ie, Clara cells and alveolar type II cells, is confirmed by immunohistochemistry. The patient had no history of dilatation and curettage; therefore, implantation of fetal tissue could be excluded from the differential diagnoses. Since this is a newly developed mass in an adult individual, we favor a neoplastic process over heterotopia and interpret the lesion as unilateral lung development in an extragonadal mature teratoma.
Khoor
A
A
Department of Pathology, Vanderbilt University Medical Center, Nashville, Tenn, USA.
Fleming
M V
MV
Purcell
C A
CA
Seidman
J D
JD
Ashton
A H
AH
Weaver
D L
DL
D000328:Adult; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008168:Lung; D013724:Teratoma / Q000473:pathology*; D002583:Uterine Cervical Neoplasms / Q000473:pathology*