title: Response of steroid-resistant graft-versus-host disease to lymphoblast antibody CBL1.
abstract: Therapy of steroid-resistant graft-versus-host disease (GVHD) with antibodies to T cells or cytokines is of limited value because GVHD is mediated by a pleomorphic group of effective cells and cytokines. CBL-1, a murine monoclonal antibody, recognises an antigen on activated T cells, B cells, and natural killer cells. We administered CBL-1 to ten patients with grade III or IV steroid-resistant GVHD. Complete remissions occurred in five cases and partial remissions in four. The organ system(s) affected by GVHD was not a predictor of response. CBL-1 was well tolerated and did not exacerbate post-transplant immunodeficiency. Our findings support the use of CBL-1 in primary prophylaxis for GVHD.
authors.affiliation: Division of Bone Marrow Transplantation, St Jude Children's Research Hospital, Memphis, TN 38101, USA.
authors.forename: H E
authors.initials: HE
authors.lastname: Heslop
authors.forename: E
authors.initials: E
authors.lastname: Benaim
authors.forename: M K
authors.initials: MK
authors.lastname: Brenner
authors.forename: R A
authors.initials: RA
authors.lastname: Krance
authors.forename: L M
authors.initials: LM
authors.lastname: Stricklin
authors.forename: R J
authors.initials: RJ
authors.lastname: Rochester
authors.forename: R
authors.initials: R
authors.lastname: Billing
mesh_terms: D000293:Adolescent; D000328:Adult; D000911:Antibodies, Monoclonal / Q000627:therapeutic use*; D000943:Antigens, Differentiation / Q000276:immunology*; D001402:B-Lymphocytes / Q000276:immunology; D002648:Child; D002675:Child, Preschool; D004351:Drug Resistance; D005260:Female; D005544:Forecasting; D006017:Glycolipids / Q000276:immunology*; D006086:Graft vs Host Disease / Q000145:classification / Q000517:prevention & control / Q000628:therapy*; D006801:Humans; D016867:Immunocompromised Host; D007075:Immunoglobulin M / Q000627:therapeutic use*; D007223:Infant; D007694:Killer Cells, Natural / Q000276:immunology; D008213:Lymphocyte Activation / Q000276:immunology; D008297:Male; D008563:Membrane Lipids / Q000276:immunology*; D008775:Methylprednisolone / Q000627:therapeutic use*; D012074:Remission Induction; D013601:T-Lymphocytes / Q000276:immunology; D014181:Transplantation Immunology
chemical_list: D000911:Antibodies, Monoclonal; D000943:Antigens, Differentiation; D006017:Glycolipids; D007075:Immunoglobulin M; D008563:Membrane Lipids; D008775:Methylprednisolone