Investigations on the adsorption of quercetin on a medicinal carbonic absorbent--controlled release and stability.
The process of adsorption/desorption of quercetin (which is therapeutically used in the Ukraine owing to its antioxidant and radical scavenging activities) on the surface of the medicinal carbonic adsorbent "Dnieper" was studied. Owing to a high adsorption capacity, the adsorbent could be used as a carrier for immobilised drugs. On the basis of desorption data, liberation of quercetin from the complex quercetin-adsorbent can be characterized as rapid initial with subsequent sustained release. On the surface of the adsorbent, quercetin does not loose its antioxidative activity. However, adsorption leads to instability of quercetin as well as of kaempferol and rutin caused mainly by oxidation during storage.
Dashevsky
A N
AN
Department of Drug Technology, Kiev Institute of Postgraduate Advance for Physicians, Ukraine.
Bucar
F
F
Kartnig
T
T
D000327:Adsorption; D000975:Antioxidants / Q000737:chemistry; D002626:Chemistry, Pharmaceutical; D003692:Delayed-Action Preparations; D004355:Drug Stability; D004777:Environment; D010316:Particle Size; D011794:Quercetin / Q000008:administration & dosage / Q000737:chemistry*; D013056:Spectrophotometry, Ultraviolet; D013816:Thermodynamics
D000975:Antioxidants; D003692:Delayed-Action Preparations; D011794:Quercetin