The effect of flubendazole on the course of Trichinella spiralis infection in mice: parasitological study.
This work planned to study the effect of flubendazole against different stages of Trichinella spiralis infection in mice. Three groups of experimental animals were examined: control group, group I treated three days post infection and group II treated four week post infection. In group I, flubendazole was shown to be a very potent agent in killing Trichinella spiralis adults and larvae, when given orally in a dose of 20 mg/kg for five consecutive days. This is evidenced by the significant reduction in number, length of the female and reproductive capacity as well as the absence of the muscle larvae. However, in group II, the effect of the drug although still significant yet diminished in all parameters as compared to the early treatment. These results evoke ideas for further design of other treatment and control of the disease.
el-Temsahi
M M
MM
Department of Parasitology Faculty of Medicine, Alexandria University, Egypt.
el-Mansoury
S T
ST
D000818:Animals; D000969:Antinematodal Agents / Q000627:therapeutic use*; D005260:Female; D007422:Intestines / Q000469:parasitology; D007814:Larva; D008463:Mebendazole / Q000031:analogs & derivatives* / Q000627:therapeutic use; D051379:Mice; D018482:Muscle, Skeletal / Q000469:parasitology; D012098:Reproduction; D013552:Swine; D013997:Time Factors; D017160:Trichinella spiralis / Q000302:isolation & purification / Q000502:physiology; D014235:Trichinellosis / Q000188:drug therapy*
D000969:Antinematodal Agents; D008463:Mebendazole; C018945:flubendazole