title: Hearing threshold shifts, white-cell count and smoking status in working men.
abstract: The association between cardiovascular risk factors and high-frequency hearing loss (HFHL) was examined using medical records from 699 employees with low workplace noise exposure. High-frequency hearing (averaged frequencies of 4000, 6000 and 8000 Hz) was significantly associated with white-blood-cell (WBC) count, smoking status, mean corpuscular volume and the globulin/albumin ratio, especially in men < or = 40 years old. The association with WBC count remained significant after controlling for smoking, cholesterol, blood pressure, and determinants of blood viscosity. An increase in WBC count of 10(3)/mm3 was associated with a 1.9 decibel (dB) decline in hearing (95% Cl: 0.9, 3.0). Controlling for WBC count reduced the association between high-frequency hearing loss and smoking. Ever-smokers (former and current) compared with never-smokers demonstrated a 6.8 dB decline in hearing (95% Cl: 2.4, 11.1). Associations between HFHL and cardiovascular risk factors are most apparent in younger adults with less cumulative noise exposure. HFHL may be a population marker for susceptibility to cardiovascular and cerebrovascular disease.
authors.affiliation: Occupational Health Program, University of Alberta, Edmonton, Canada.
authors.forename: L A
authors.initials: LA
authors.lastname: Cocchiarella
authors.forename: D S
authors.initials: DS
authors.lastname: Sharp
authors.forename: V W
authors.initials: VW
authors.lastname: Persky
mesh_terms: D000328:Adult; D001809:Blood Viscosity; D002318:Cardiovascular Diseases / Q000150:complications*; D006317:Hearing Loss, Noise-Induced / Q000097:blood / Q000150:complications*; D006400:Hematocrit; D006801:Humans; D007958:Leukocyte Count; D008297:Male; D008875:Middle Aged; D009784:Occupational Diseases / Q000097:blood / Q000150:complications*; D012307:Risk Factors; D012907:Smoking / Q000009:adverse effects