Deletion 9p22-pter and loss of Y as primary chromosome abnormalities in a squamous cell carcinoma of the vocal cord.
Loss of distal 9p is a common genetic alteration in squamous cell carcinoma of the head and neck. A vocal cord lesion incorporating a carcinoma-in-situ and a focus of invasive carcinoma revealed loss of the Y chromosome and a 9p22 rearrangement with loss of 9p22-pter. Loss of 9p22-pter appears to be a primary autosomal abnormality in this squamous cell carcinoma.
Worsham
M J
MJ
Cytogenetics Laboratory, University of Michigan Cancer Center, Ann Arbor.
Benninger
M J
MJ
Zarbo
R J
RJ
Carey
T E
TE
Van Dyke
D L
DL
D002294:Carcinoma, Squamous Cell / Q000235:genetics*; D002872:Chromosome Deletion; D002899:Chromosomes, Human, Pair 9; D006801:Humans; D007621:Karyotyping; D007822:Laryngeal Neoplasms / Q000235:genetics*; D008297:Male; D008875:Middle Aged; D014998:Y Chromosome