title: New frontiers in myocardial protection: harnessing the heart's endogenous protective systems.
abstract: Researchers have continued to search for therapeutic agents to protect the heart during ischemia and reperfusion. Recent studies have suggested that harnessing the heart's endogenous systems for self-preservation may provide improved protection from ischemic injury. Two such phenomena, preconditioning and heat-shock protein synthesis, have been shown to uniformly reduce myocardial damage. This review highlights the newest research in myocardial protective strategies and suggests avenues of future investigation.
authors.affiliation: Surgical Research Center, University of Connecticut School of Medicine, Farmington, USA.
authors.forename: D T
authors.initials: DT
authors.lastname: Engelman
mesh_terms: D000222:Adaptation, Physiological; D000255:Adenosine Triphosphate / Q000502:physiology*; D000818:Animals; D006360:Heat-Shock Proteins / Q000502:physiology*; D006801:Humans; D015428:Myocardial Reperfusion Injury / Q000503:physiopathology* / Q000517:prevention & control*; D013312:Stress, Physiological / Q000503:physiopathology
chemical_list: D006360:Heat-Shock Proteins; D000255:Adenosine Triphosphate