The estimation of local brain temperature by in vivo 1H magnetic resonance spectroscopy.
Brain temperature may be important for investigating pathology and cerebroprotective effects of pharmaceuticals and hypothermia. Two methods for estimating temperature using 1H magnetic resonance spectroscopy are described: a partially water-suppressed binomial sequence and non-water-suppressed point-resolved spectroscopy. Relative to N-acetylaspartate (Naa), water chemical shift (delta H2O-Naa) in piglet brain depended linearly on temperature from 30 degrees to 40 degrees C: temperature was 286.9-94.0 delta H2O-Naa degrees C. Thalamic temperature in six normal infants was 38.1 degrees +/- 0.4 degree C indicating that local brain temperature could be estimated with adequate sensitivity for studying pathologic and therapeutic changes.
Cady
E B
EB
Department of Medical Physics and Bio-Engineering, University College London Hospitals NHS Trust, England.
D'Souza
P C
PC
Penrice
J
J
Lorek
A
A
D000818:Animals; D000831:Animals, Newborn; D001224:Aspartic Acid / Q000031:analogs & derivatives / Q000032:analysis; D001831:Body Temperature; D001921:Brain / Q000502:physiology*; D001923:Brain Chemistry; D006801:Humans; D006863:Hydrogen-Ion Concentration; D007231:Infant, Newborn; D009682:Magnetic Resonance Spectroscopy / Q000379:methods; D013552:Swine
D001224:Aspartic Acid; C000179:N-acetylaspartate