Acrokeratosis paraneoplastica (Bazex syndrome) associated with primary cutaneous squamous cell carcinoma of the lower leg, vitiligo and alopecia areata.
We report a case of acrokeratosis paraneoplastica (AP; Bazex syndrome), characterized by typical palmoplantar hyperkeratosis and psoriasiform scaly erythema of the acral regions, associated with primary cutaneous squamous cell carcinoma (SCC) on the left lower leg. This 54-year-old Japanese man subsequently developed vitiligo, and alopecia areata of the scalp. Serial monitoring of squamous cell carcinoma antigen (SCC-Ag) demonstrated that the severity of the clinical manifestations of AP paralleled the serum concentrations of SCC-Ag. We suggest that an immune-mediated mechanism underlies the development of AP in this patient.
Hara
M
M
Department of Dermatology, Tohoku University School of Medicine, Sendai, Japan.
Hunayama
M
M
Aiba
S
S
Suetake
T
T
Watanabe
M
M
Tanaka
M
M
Tagami
H
H
D000506:Alopecia Areata / Q000209:etiology; D002294:Carcinoma, Squamous Cell / Q000150:complications*; D006801:Humans; D007866:Leg; D008297:Male; D008875:Middle Aged; D010257:Paraneoplastic Syndromes / Q000209:etiology* / Q000473:pathology; D012871:Skin Diseases / Q000209:etiology* / Q000473:pathology; D012878:Skin Neoplasms / Q000150:complications*; D014820:Vitiligo / Q000209:etiology