title: Human H-Y: a male-specific histocompatibility antigen derived from the SMCY protein.
abstract: H-Y is a transplantation antigen that can lead to rejection of male organ and bone marrow grafts by female recipients, even if the donor and recipient match at the major histocompatibility locus of humans, the HLA (human leukocyte antigen) locus. However, the origin and function of H-Y antigens has eluded researchers for 40 years. One human H-Y antigen presented by HLA-B7 was identified as an 11-residue peptide derived from SMCY, an evolutionarily conserved protein encoded on the Y chromosome. The protein from the homologous gene on the X chromosome, SMCX, differs by two amino acid residues in the same region. The identification of H-Y may aid in transplantation prognosis, prenatal diagnosis, and fertilization strategies.
authors.affiliation: Department of Microbiology, University of Virginia, Charlottesville 22908, USA.
authors.forename: W
authors.initials: W
authors.lastname: Wang
authors.forename: L R
authors.initials: LR
authors.lastname: Meadows
authors.forename: J M
authors.initials: JM
authors.lastname: den Haan
authors.forename: N E
authors.initials: NE
authors.lastname: Sherman
authors.forename: Y
authors.initials: Y
authors.lastname: Chen
authors.forename: E
authors.initials: E
authors.lastname: Blokland
authors.forename: J
authors.initials: J
authors.lastname: Shabanowitz
authors.forename: A I
authors.initials: AI
authors.lastname: Agulnik
authors.forename: R C
authors.initials: RC
authors.lastname: Hendrickson
authors.forename: C E
authors.initials: CE
authors.lastname: Bishop
mesh_terms: D000595:Amino Acid Sequence; D001402:B-Lymphocytes; D002460:Cell Line; D002851:Chromatography, High Pressure Liquid; D006182:H-Y Antigen / Q000737:chemistry* / Q000235:genetics / Q000276:immunology; D015793:HLA-B7 Antigen / Q000276:immunology; D056466:Histone Demethylases; D011495:Histone-Lysine N-Methyltransferase; D006801:Humans; D008297:Male; D013058:Mass Spectrometry / Q000379:methods; D015778:Minor Histocompatibility Antigens; D008969:Molecular Sequence Data; D008970:Molecular Weight; D010089:Oxidoreductases, N-Demethylating; D011506:Proteins / Q000737:chemistry* / Q000235:genetics / Q000276:immunology; D013602:T-Lymphocytes, Cytotoxic / Q000276:immunology; D014960:X Chromosome; D014998:Y Chromosome
chemical_list: D006182:H-Y Antigen; D015793:HLA-B7 Antigen; D015778:Minor Histocompatibility Antigens; D011506:Proteins; D056466:Histone Demethylases; C086877:KDM5C protein, human; C095561:KDM5D protein, human; D010089:Oxidoreductases, N-Demethylating; D011495:Histone-Lysine N-Methyltransferase