Dipsogenic effects of excitatory amino acid agonists in pigeons.
Three excitatory amino acid agonists [N-methyl-D-aspartate (NMDA), kainate and alpha-amino-2,3-dihyro-5-methyl-3-oxo-4-isoxalzolepropanoic acid], each selective for separate glutamate binding sites, were evaluated for dipsogenic responses in pigeons. NMDA and kainate produced a reliable and rapid drinking response (up to 30% of body weight over 3 hr). alpha-amino-2,3-dihyro-5-methyl-3-oxo-4-isoxalzolepropanoic acid, up to doses which produced profound effects on motor behavior (18.0 mg/kg i.m.), did not produce a reliable drinking response. The dipsogenic effects of NMDA and its stereoisomer, N-methyl-L-aspartate, were antagonized by the competitive NMDA antagonist, cis-4-(phosphonomethyl)-2-piperidinecarboxylic acid. cis-4-(phosphonomethyl)-2-Piperidinecarboxylic acid failed to prevent drinking produced by kainate or water deprivation. These results suggest that NMDA-, kainate- and water deprivation-induced drinking are mediated via separate mechanisms and that NMDA induced drinking is mediated via NMDA receptors.
Baron
S P
SP
Department of Psychology, University of Michigan, Ann Arbor.
Woods
J H
JH
D000818:Animals; D010856:Columbidae; D004326:Drinking / Q000187:drug effects*; D007051:Ibotenic Acid / Q000031:analogs & derivatives* / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology*; D016202:N-Methylaspartate / Q000494:pharmacology*; D010875:Pipecolic Acids / Q000494:pharmacology; D016194:Receptors, N-Methyl-D-Aspartate / Q000187:drug effects; D013237:Stereoisomerism; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid
D010875:Pipecolic Acids; D016194:Receptors, N-Methyl-D-Aspartate; D007051:Ibotenic Acid; C053672:selfotel; D016202:N-Methylaspartate; D018350:alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid; D007608:Kainic Acid