The nuclear receptor steroidogenic factor 1 is essential for the formation of the ventromedial hypothalamic nucleus.
The nuclear receptor steroidogenic factor 1 (SF-1) regulates the biosynthesis of the two essential mediators of male sexual differentiation, androgens and Müllerian-inhibiting substance, and is required for adrenal and gonadal development and gonadotropin expression. SF-1 is also expressed in the embryonic ventral diencephalon, subsequently localizing to the ventromedial hypothalamic nucleus, a region important for reproductive behavior. Mice lacking SF-1 secondary to targeted disruption of the Ftz-F1 gene had normal numbers and location of GnRH neurons but exhibited grossly impaired ventromedial hypothalamic nucleus structure. Despite their apparently normal GnRH neurons, treatment of Ftz-F1-disrupted mice with GnRH restored pituitary gonadotropin expression. These studies define SF-1's essential role within a discrete hypothalamic nucleus previously linked to reproduction.
Ikeda
Y
Y
Department of Medicine, Duke University Medical Center, Durham, North Carolina 27710, USA.
Luo
X
X
Abbud
R
R
Nilson
J H
JH
Parker
K L
KL
D000818:Animals; D002465:Cell Movement; D004268:DNA-Binding Proteins / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D005260:Female; D051717:Fushi Tarazu Transcription Factors; D018507:Gene Expression Regulation, Developmental; D007987:Gonadotropin-Releasing Hormone / Q000096:biosynthesis / Q000235:genetics / Q000627:therapeutic use; D006065:Gonadotropins, Pituitary / Q000096:biosynthesis / Q000235:genetics; D018398:Homeodomain Proteins; D007030:Hypothalamo-Hypophyseal System / Q000503:physiopathology*; D008297:Male; D051379:Mice; D018345:Mice, Knockout; D009474:Neurons / Q000378:metabolism / Q000648:ultrastructure; D018160:Receptors, Cytoplasmic and Nuclear; D011966:Receptors, LHRH / Q000096:biosynthesis / Q000235:genetics; D012733:Sex Differentiation / Q000235:genetics; D054339:Steroidogenic Factor 1; D014157:Transcription Factors / Q000172:deficiency / Q000235:genetics / Q000378:metabolism / Q000502:physiology*; D014697:Ventromedial Hypothalamic Nucleus / Q000196:embryology* / Q000254:growth & development / Q000378:metabolism / Q000473:pathology
D004268:DNA-Binding Proteins; D051717:Fushi Tarazu Transcription Factors; D006065:Gonadotropins, Pituitary; D018398:Homeodomain Proteins; D018160:Receptors, Cytoplasmic and Nuclear; D011966:Receptors, LHRH; D054339:Steroidogenic Factor 1; D014157:Transcription Factors; C515058:steroidogenic factor 1, mouse; D007987:Gonadotropin-Releasing Hormone