[Myasthenia induced by tiopronin in the treatment of rheumatoid arthritis].
Myasthenia gravis (MG) is a well known side-effect of D-Penicillamine used in the treatment of rheumatoid polyarthritis. Tiopronin is another drug available in France, which can also induce MG. Drug-induced MG are characterized by frequent involvement of facial and oropharyngeal muscles. Moreover, the generalization is scarce and the outcome always quite good. No thymoma is present, anti-acetylcholine receptors antibodies are often highly positive. Furthermore, some HLA phenotypes are most frequently found among patients with drug-induced MG suggesting a genetic predisposition. This observation underlines the interest of careful management of patients treated by tiopronin.
Bonnet
M
M
Service de Neurologie, Centre Hospitalier Universitaire, Hôpital Purpan, Toulouse.
Angibaud
G
G
Cantagrel
A
A
Montastruc
J L
JL
Clanet
M
M
D000368:Aged; D000596:Amino Acids / Q000009:adverse effects / Q000627:therapeutic use; D001172:Arthritis, Rheumatoid / Q000188:drug therapy*; D005260:Female; D006801:Humans; D009157:Myasthenia Gravis / Q000139:chemically induced*; D008625:Tiopronin / Q000009:adverse effects* / Q000627:therapeutic use
D000596:Amino Acids; D008625:Tiopronin
Myasthénie induite par la tiopronine au cours du traitement de la polyarthrite rhumatoïde.