title: Antifungal agents. 10. Synthesis and antifungal activities of aryl-(1H-imidazol-1-yl)-(isoquinolin-1-yl) methane derivatives.
abstract: Various aryl-(1H-imidazol-1-yl)-(isoquinolin-1-yl)methane derivatives have been synthesized and tested as antifungal agents. The new imidazoles have been obtained by the action of 1,1'-sulfinyldiimidazole on aryl-(isoquinolin-1-yl)carbinols, which have been prepared by standard procedures starting from isoquinoline. Among 44 test derivatives only a few have exhibited some antifungal activity, the most active compound (4e) being twofold less potent than miconazole, ketoconazole and bifonazole, used as standard drugs.
authors.affiliation: Dipartimento di Studi Farmaceutici, Università di Roma La Sapienza, Roma, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Silvestri
authors.forename: E
authors.initials: E
authors.lastname: Pagnozzi
authors.forename: F
authors.initials: F
authors.lastname: Troccoli
authors.forename: G
authors.initials: G
authors.lastname: Stefancich
authors.forename: S
authors.initials: S
authors.lastname: Massa
authors.forename: G
authors.initials: G
authors.lastname: Apuzzo
authors.forename: M E
authors.initials: ME
authors.lastname: Perazzi
authors.forename: M
authors.initials: M
authors.lastname: Artico
authors.forename: G
authors.initials: G
authors.lastname: Simonetti
mesh_terms: D000935:Antifungal Agents / Q000138:chemical synthesis / Q000494:pharmacology*; D002175:Candida / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D007093:Imidazoles / Q000138:chemical synthesis / Q000494:pharmacology*; D007546:Isoquinolines / Q000138:chemical synthesis / Q000494:pharmacology*; D009682:Magnetic Resonance Spectroscopy; D008826:Microbial Sensitivity Tests; D015394:Molecular Structure
chemical_list: D000935:Antifungal Agents; D007093:Imidazoles; D007546:Isoquinolines