[A comparative analysis of the effect of nootropic preparations with different chemical structures on the failure of the escape reaction in rats].
The nootropic agents pyroglutamyl-D-alanine amide (TGS-20), mechlofenoxate, and mexidole versus piracetam were tested for their effects on the reversible impairments of cognitive brain functions, on the demolition of active avoidance responses in rats. TGS-20 (1 mg/kg/day) and mexidole (10 mg/kg/day) injected intraperitoneally 30 minutes prior to the experiment showed a normalizing effect in smaller doses than did piracetam (300 mg/kg/day). Mechlofenoxate (50 mg/kg/day) displayed a lower protective effect.
Inozemtsev
A N
AN
Pragina
P L
PL
Firova
F A
FA
Trofimov
S S
SS
Gudasheva
T A
TA
Tushmalova
N A
NA
Ostrovskaia
R U
RU
Voronina
T A
TA
D000818:Animals; D003214:Conditioning, Classical / Q000187:drug effects; D004305:Dose-Response Relationship, Drug; D004924:Escape Reaction / Q000187:drug effects*; D005108:Extinction, Psychological / Q000187:drug effects*; D008297:Male; D018697:Nootropic Agents / Q000494:pharmacology*; D051381:Rats; D018709:Statistics, Nonparametric; D013329:Structure-Activity Relationship
D018697:Nootropic Agents
Sravnitel'nyĭ analiz vliianiia nootropnykh preparatov razlichnoĭ khimicheskoĭ struktury na sboĭ reaktsii izbeganiia u krys.