Acute low-intensity microwave exposure increases DNA single-strand breaks in rat brain cells.
Levels of DNA single-strand break were assayed in brain cells from rats acutely exposed to low-intensity 2450 MHz microwaves using an alkaline microgel electrophoresis method. Immediately after 2 h of exposure to pulsed (2 microseconds width, 500 pulses/s) microwaves, no significant effect was observed, whereas a dose rate-dependent [0.6 and 1.2 W/kg whole body specific absorption rate (SAR)] increase in DNA single-strand breaks was found in brain cells of rats at 4 h postexposure. Furthermore, in rats exposed for 2 h to continuous-wave 2450 MHz microwaves (SAR 1.2 W/kg), increases in brain cell DNA single-strand breaks were observed immediately as well as at 4 h postexposure.
Lai
H
H
Department of Pharmacology, University of Washington, Seattle 98195, USA.
Singh
N P
NP
D000704:Analysis of Variance; D000818:Animals; D001921:Brain / Q000528:radiation effects; D004247:DNA / Q000528:radiation effects*; D004249:DNA Damage; D004586:Electrophoresis; D006624:Hippocampus / Q000528:radiation effects; D008297:Male; D008872:Microwaves; D009474:Neurons / Q000502:physiology / Q000528:radiation effects*; D051381:Rats; D017207:Rats, Sprague-Dawley
D004247:DNA