title: Use of Sinemet in locked-in syndrome: a report of two cases.
abstract: Locked-in syndrome describes a neurological condition usually associated with infarction of the ventral pons. Such patients are diagnosed with quadriplegia, lower cranial nerve paralysis, and mutism. The patient is alert but communication is severely limited and usually is accomplished by blinking or using vertical eye movements. The rehabilitative management of locked-in syndrome has consisted of preventative and supportive measures. In this study we report two cases of locked-in syndrome which were treated successfully with Sinemet (DuPont Pharmaceuticals, Wilmington, DE). Even though the exact neuropharmacological mechanism is unclear, the dramatic improvement in these cases, as well as in one other published case report, dictates that use of Sinemet should be considered in the management of locked-in syndrome.
authors.affiliation: Department of Rehabilitation Medicine, University of Kansas Medical Center, Kansas City 66103, USA.
authors.forename: R R
authors.initials: RR
authors.lastname: Ockey
authors.forename: D
authors.initials: D
authors.lastname: Mowry
authors.forename: G
authors.initials: G
authors.lastname: Varghese
mesh_terms: D000328:Adult; D002230:Carbidopa / Q000627:therapeutic use*; D002648:Child; D018491:Dopamine Agonists / Q000627:therapeutic use*; D004338:Drug Combinations; D006801:Humans; D007980:Levodopa / Q000627:therapeutic use*; D008297:Male; D011782:Quadriplegia / Q000188:drug therapy* / Q000503:physiopathology
chemical_list: D018491:Dopamine Agonists; D004338:Drug Combinations; C009265:carbidopa, levodopa drug combination; D007980:Levodopa; D002230:Carbidopa