title: [Gallbladder cancer in the IX Region of Chile. Impact of the anatomopathological study of 474 cases].
abstract: We studied prospectively 474 cases (83% female with a female:male ratio of 5:1) of gallbladder carcinoma diagnosed in a period of 7 years. Twenty two percent of patients were younger than 50 years old. Ninety percent of tumors were adenocarcinomas. In 1987, 45% of cases were diagnosed in metastases compared to 1993, when only 10% of tumors were diagnosed in such histological material. Thirty four percent of tumors were not macroscopically identified; all these inapparent tumors were advanced in 1987, whereas 53% were incipient in 1993. Moreover, inapparent tumors had a significantly lower degree of gallbladder wall infiltration and higher degree of differentiation. Well differentiated tumors had a lesser degree of wall infiltration. It is concluded that the careful histopathological study of gallbladder cancer has allowed a thorough knowledge of the natural history and clinical presentation of gallbladder carcinoma.
authors.affiliation: Unidad de Anatomía Patológica y Citopatología, Facultad de Medicina, Universidad de la Frontera, Hospital Regional de Temuco, Chile.
authors.forename: I
authors.initials: I
authors.lastname: Roa
authors.forename: J C
authors.initials: JC
authors.lastname: Araya
authors.forename: I
authors.initials: I
authors.lastname: Wistuba
authors.forename: M
authors.initials: M
authors.lastname: Villaseca
authors.forename: X
authors.initials: X
authors.lastname: de Aretxabala
authors.forename: L
authors.initials: L
authors.lastname: Burgos
mesh_terms: D000230:Adenocarcinoma / Q000473:pathology* / Q000556:secondary; D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D002677:Chile; D005260:Female; D005706:Gallbladder Neoplasms / Q000473:pathology*; D006801:Humans; D007199:Indians, South American; D008297:Male; D008875:Middle Aged; D011446:Prospective Studies
vernacular_title: Cáncer de vesícula biliar en la IX región de Chile. Impacto del estudio anatomopatológico en 474 casos.