Injection of anti-neuropeptide Y gamma-globulin into the hypothalamic paraventricular nucleus decreases food intake in rats.
The effect of immunoneutralization of hypothalamic neuropeptide Y (NPY) on food intake was examined to clarify the involvement of NPY in the control mechanism of feeding behavior. Injection of anti-NPY gamma-globulin into the bilateral hypothalamic paraventricular nuclei of 24-h food-deprived rats significantly inhibited food intake for 1 h after the injection compared with rats that received normal rabbit gamma-globulin. This result suggests that NPY in the paraventricular nucleus plays a role in stimulating feeding behavior.
Shibasaki
T
T
Department of Medicine, Tokyo Women's Medical College, Japan.
Oda
T
T
Imaki
T
T
Ling
N
N
Demura
H
H
D000818:Animals; D003864:Depression, Chemical; D004435:Eating / Q000187:drug effects*; D007267:Injections; D008297:Male; D009478:Neuropeptide Y / Q000276:immunology* / Q000502:physiology; D010286:Paraventricular Hypothalamic Nucleus / Q000033:anatomy & histology / Q000187:drug effects / Q000502:physiology*; D051381:Rats; D017208:Rats, Wistar; D005719:gamma-Globulins / Q000008:administration & dosage / Q000494:pharmacology*
D009478:Neuropeptide Y; D005719:gamma-Globulins