Effect of a total extract from Fraxinus ornus stem bark and esculin on zymosan- and carrageenan-induced paw oedema in mice.
This study investigates the total ethanol extract (TE) of the stem bark of Fraxinus ornus and its constituent esculin (EN). They inhibited classical pathway (CP) and alternative pathway (AP) of complement activation in mouse serum. After intraperitoneal administration the total extract displayed antiinflammatory activity in both zymosan- and carrageenan-induced paw oedema in mice. The results suggest that the traditional use of Fraxinus ornus stem bark extracts in the treatment of inflammatory disorders is at least partially due to its coumarin constituents.
Stefanova
Z
Z
Department of Immunology, Bulgarian Academy of Sciences, Sofia.
Neychev
H
H
Ivanovska
N
N
Kostova
I
I
D000818:Animals; D002031:Bulgaria; D002351:Carrageenan / Q000633:toxicity; D003167:Complement Activation / Q000187:drug effects; D015941:Complement Hemolytic Activity Assay; D003169:Complement Inactivator Proteins / Q000494:pharmacology; D004195:Disease Models, Animal; D004487:Edema / Q000139:chemically induced / Q000188:drug therapy*; D004929:Esculin / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D000431:Ethanol / Q000737:chemistry; D006614:Hindlimb; D007274:Injections, Intraperitoneal; D051379:Mice; D010936:Plant Extracts / Q000008:administration & dosage / Q000494:pharmacology / Q000627:therapeutic use*; D014197:Trees; D015054:Zymosan / Q000633:toxicity
D003169:Complement Inactivator Proteins; D010936:Plant Extracts; D004929:Esculin; D000431:Ethanol; D002351:Carrageenan; D015054:Zymosan