Synthesis and antimicrobial evaluation of new quinazolinone derivatives.
A new hydrazide, 3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetic acid hydrazide 3 was synthesized by the reaction of 3-ethyl-4(3H)-quinazolinone-2-ylmercaptoacetic acid ethyl ester with hydrazine hydrate. Subsequent treatment of 3 with aromatic aldehydes and alkyl/arylisothiocyanates furnished the corresponding hydrazones 4a-f and the thiosemicarbazides 5a-e, respectively. Cyclocondensation of 5a-e in sulfuric acid yielded the thiadiazoles 6a-d. All the synthesized compounds were tested for in vitro antimicrobial action against some aerobic bacteria and C. albicans.
Gürsoy
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A
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Istanbul, Beyazit, Turkey.
Ilhan
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N
D042462:4-Quinolones; D000890:Anti-Infective Agents / Q000138:chemical synthesis* / Q000737:chemistry / Q000494:pharmacology; D000995:Antitubercular Agents / Q000138:chemical synthesis / Q000494:pharmacology; D001419:Bacteria / Q000187:drug effects; D002176:Candida albicans / Q000187:drug effects; D008826:Microbial Sensitivity Tests; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
D042462:4-Quinolones; D000890:Anti-Infective Agents; D000995:Antitubercular Agents