title: Significance of aminopyrine breath test as a parameter of hepatic functional reserve in 40% partial hepatectomy of rats with CCl4-induced liver injury.
abstract: Rats with CCl4-induced liver injury underwent partial (40%) hepatectomy. The [14C]aminopyrine breath test (ABT) values in rats with CCl4-induced liver injury were reduced by 34% compared with those in rats with normal liver. Preoperative ABT values clearly discriminated between survivors and those that died following 40% partial hepatectomy in rats CCl4-induced liver injury (P < 0.05). Hepatic protein synthesis was remarkably enhanced in CCl4-induced liver injury compared with normal liver (P < 0.001), and this was inversely correlated with ABT values (P < 0.001). These data show that the enhanced hepatic protein synthesis could induce a decrease of hepatic functional reserve. ABT seems to be a useful preoperative test for predicting surgical mortality following hepatectomy.
authors.affiliation: 1st Department of Surgery, School of Medicine, Chiba University, Japan.
authors.forename: M
authors.initials: M
authors.lastname: Miyazaki
authors.forename: T
authors.initials: T
authors.lastname: Sugasawa
authors.forename: H
authors.initials: H
authors.lastname: Itoh
authors.forename: T
authors.initials: T
authors.lastname: Kaiho
authors.forename: K
authors.initials: K
authors.lastname: Ando
authors.forename: S
authors.initials: S
authors.lastname: Anbiru
authors.forename: S
authors.initials: S
authors.lastname: Ohtawa
authors.forename: A
authors.initials: A
authors.lastname: Ogata
authors.forename: N
authors.initials: N
authors.lastname: Yasuda
authors.forename: S
authors.initials: S
authors.lastname: Hayashi
mesh_terms: D000410:Alanine Transaminase / Q000378:metabolism; D000632:Aminopyrine; D000818:Animals; D001219:Aspartate Aminotransferases / Q000378:metabolism; D001944:Breath Tests; D002251:Carbon Tetrachloride; D006498:Hepatectomy; D008099:Liver / Q000502:physiology*; D008106:Liver Cirrhosis, Experimental / Q000139:chemically induced / Q000175:diagnosis / Q000503:physiopathology* / Q000601:surgery; D008111:Liver Function Tests; D008297:Male; D014176:Protein Biosynthesis; D051381:Rats; D017208:Rats, Wistar
chemical_list: D000632:Aminopyrine; D002251:Carbon Tetrachloride; D001219:Aspartate Aminotransferases; D000410:Alanine Transaminase