title: Tissue reactions around a hydroxyapatite-coated hip prosthesis. Case report of a retrieved specimen.
abstract: Bone reactions were studied around a titanium, hydroxyapatite (HA)-coated Osteonics (Allendale, NJ) bipolar hip prosthesis, which was revised for severe midthigh pain 4 years after implantation. Inspection of the retrieved prosthesis using a dissecting microscope revealed scarce remnants of a coating-like material on the surface of the prosthesis; however, histology of this layer and histology of the bony side of the bone--HA interface failed to reveal any remnants of an HA coating. The interface was covered predominantly by trabecular bone, which closely followed the contour of the prosthesis, and was partly woven nonmineralized bone. At locations where mineralized bone faced the prosthesis, many small dark titanium wear particles were found. Similar particles were found in macrophages in the intertrabecular medullary space. Polyethylene wear particles were specifically located in macrophages in a soft tissue interface at more distal levels along the stem of the prosthesis. Although the observations presented in this case cannot be generalized, it clearly shows that the HA coating layer had completely disappeared after 4 years. More detailed retrieval studies and longer clinical follow-up studies are needed before a final evaluation of the behavior of HA coatings and long-term fixation of HA-coated prostheses can be made.
authors.affiliation: Department of Orthopaedics, University Hospital Nijmegen, The Netherlands.
authors.forename: P
authors.initials: P
authors.lastname: Buma
authors.forename: J W
authors.initials: JW
authors.lastname: Gardeniers
mesh_terms: D000328:Adult; D005271:Femur Head Necrosis / Q000601:surgery; D005547:Foreign Bodies; D006622:Hip Prosthesis; D006801:Humans; D006882:Hydroxyapatites / Q000627:therapeutic use*; D008875:Middle Aged; D016348:Osseointegration; D011183:Postoperative Complications; D012086:Reoperation; D014025:Titanium
chemical_list: D006882:Hydroxyapatites; D014025:Titanium