Galanin activates an inwardly rectifying potassium conductance in mudpuppy atrial myocytes.
Galanin- and bethanechol-activated K+ currents have been studied in mudpuppy atrial myocytes. The galanin and bethanechol K+ currents were time-dependent and inwardly rectifying. In GTP gamma S, the galanin and bethanechol currents were reduced progressively as G-protein gated K+ channels became activated. GDP beta S inhibited agonist-induced outward currents. We conclude that galanin and bethanechol activate the same or a very similar inwardly rectifying K+ conductance and that activation of a G protein is required.
Parsons
R L
RL
Department of Anatomy and Neurobiology, University of Vermont College of Medicine, Burlington 05405.
Merriam
L A
LA
D000818:Animals; D016275:Atrial Function; D018723:Bethanechol; D001626:Bethanechol Compounds / Q000494:pharmacology*; D019004:Galanin; D016244:Guanosine 5'-O-(3-Thiotriphosphate) / Q000494:pharmacology*; D006153:Guanosine Diphosphate / Q000031:analogs & derivatives* / Q000494:pharmacology; D006325:Heart Atria / Q000166:cytology / Q000187:drug effects; D008564:Membrane Potentials / Q000187:drug effects / Q000502:physiology; D009337:Necturus; D010455:Peptides / Q000494:pharmacology*; D011188:Potassium / Q000378:metabolism*; D013873:Thionucleotides / Q000494:pharmacology*
D001626:Bethanechol Compounds; D010455:Peptides; D013873:Thionucleotides; D018723:Bethanechol; D006153:Guanosine Diphosphate; D016244:Guanosine 5'-O-(3-Thiotriphosphate); C023427:guanosine 5'-O-(2-thiodiphosphate); D019004:Galanin; D011188:Potassium