Alternative splicing of the type-IVA cyclic AMP phosphodiesterase gene provides isoform variants with distinct N-terminal domains fused to a common, soluble catalytic unit: 'designer' changes in Vmax, stability and membrane association.
Houslay
M D
MD
Division of Biochemistry & Molecular Biology, University of Glasgow, Scotland, U.K.
Scotland
G
G
Pooley
L
L
Spence
S
S
Wilkinson
I
I
McCallum
F
F
Julien
P
P
Rena
N G
NG
Michie
A M
AM
Erdogan
S
S
D015105:3',5'-Cyclic-AMP Phosphodiesterases / Q000096:biosynthesis* / Q000378:metabolism; D017398:Alternative Splicing; D000595:Amino Acid Sequence; D000818:Animals; D002462:Cell Membrane / Q000201:enzymology; D006801:Humans; D007527:Isoenzymes / Q000096:biosynthesis* / Q000378:metabolism; D007700:Kinetics; D008969:Molecular Sequence Data; D017384:Sequence Deletion
D007527:Isoenzymes; D015105:3',5'-Cyclic-AMP Phosphodiesterases