Simultaneous treatment with IGF-I and GH additively increases anabolism in parenterally fed rats.
We compared the effects of recombinant human insulin-like growth factor I [rhIGF-I, 800 micrograms/day, coinfused with total parenteral nutrition (TPN)], growth hormone (rhGH, 800 micrograms/day, subcutaneous injection twice daily), and simultaneous treatment with rhIGF-I and rhGH (800 + 800 micrograms/day) in rats subjected to surgical stress and maintained with TPN. Weight gain induced by IGF-I plus GH was double that shown by IGF-I or GH alone. Although weight gain was similar with IGF-I or GH, IGF-I selectively increased heart, kidney, thymus, spleen, and small intestine mass, whereas GH selectively increased gastrocnemius muscle mass. IGF-I and/or GH increased carcass protein and water while decreasing fat. Serum total and free IGF-I levels were highest with IGF-I plus GH. Serum rat GH levels were reduced with IGF-I and/or GH. IGF-I given with GH reversed the GH-induced increase in serum insulin. In summary, IGF-I and GH show tissue-specific anabolic effects, and simultaneous treatment with IGF-I plus GH additively increases anabolism during TPN.
Lo
H C
HC
Department of Nutritional Sciences, University of Wisconsin-Madison 53706, USA.
Hinton
P S
PS
Peterson
C A
CA
Ney
D M
DM
D000824:Animal Nutritional Physiological Phenomena; D000818:Animals; D001823:Body Composition / Q000187:drug effects; D001835:Body Weight / Q000187:drug effects; D004338:Drug Combinations; D013006:Growth Hormone / Q000008:administration & dosage*; D006728:Hormones / Q000097:blood; D007334:Insulin-Like Growth Factor I / Q000008:administration & dosage*; D008297:Male; D008660:Metabolism / Q000187:drug effects*; D009584:Nitrogen / Q000378:metabolism; D009929:Organ Size / Q000187:drug effects; D009994:Osmolar Concentration; D010289:Parenteral Nutrition, Total; D051381:Rats
D004338:Drug Combinations; D006728:Hormones; D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone; D009584:Nitrogen