[Fibroblast growth factors (FGF-2) and delayed involution of the posterior limbs of the slow-worm embryo (Anguis fragilis, L.)].
Administration at doses of 1,800 ng to 6,200 ng of basic fibroblast growth factor (bFGF), around the posterior limb buds of young slow-worm (Anguis fragilis, L.) embryos developing in cultured eggs has, after 4 to 6 days, in several embryos (10 among 15, treated at stage of allantoic bud, from 3 to 9 mm long), delayed the involution of these posterior limbs: their anlagen are larger than the control ones and histological examination shows an increase, between 20% and 30%, of cell density in the mesodermal component of the limb bud. These results bring into light the possibility to control, to some degree, the regressive evolution of the limbs.
Raynaud
A
A
Laboratoire de zoologie, Université Paul-Sabatier, Toulouse, France.
Kan
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P
Bouche
G
G
Duprat
A M
AM
D000818:Animals; D016222:Fibroblast Growth Factor 2 / Q000494:pharmacology*; D006614:Hindlimb / Q000187:drug effects* / Q000196:embryology*; D066298:In Vitro Techniques; D008116:Lizards / Q000196:embryology*
D016222:Fibroblast Growth Factor 2
Facteur de croissance des fibroblastes (FGF-2) et retard d'involution des membres postérieurs de l'embryon d'orvet (Anguis fragilis, L.).