Morphine-induced suppression of thymocyte proliferation is mediated by inhibition of IL-2 synthesis.
Roy
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Department of Surgery, University of Minnesota, Minneapolis 55455, USA.
Loh
H H
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Barke
R A
RA
D000818:Animals; D015152:Blotting, Northern; D002455:Cell Division / Q000187:drug effects; D015870:Gene Expression / Q000187:drug effects; D017403:In Situ Hybridization; D007375:Interleukin-1 / Q000494:pharmacology; D007376:Interleukin-2 / Q000096:biosynthesis*; D008213:Lymphocyte Activation / Q000187:drug effects*; D051379:Mice; D008813:Mice, Inbred ICR; D009020:Morphine / Q000494:pharmacology*; D009270:Naloxone / Q000494:pharmacology; D010835:Phytohemagglutinins / Q000494:pharmacology; D012333:RNA, Messenger / Q000096:biosynthesis / Q000302:isolation & purification; D013601:T-Lymphocytes / Q000187:drug effects* / Q000378:metabolism*; D013936:Thymidine / Q000378:metabolism
D007375:Interleukin-1; D007376:Interleukin-2; D010835:Phytohemagglutinins; D012333:RNA, Messenger; D009270:Naloxone; D009020:Morphine; D013936:Thymidine