[Chronic bullous dermatosis in childhood. Association with salmonella enteritis].
We report on a 2-year-old girl with chronic bullous disease of childhood (CBDC). Concomitantly with a feverish gastrointestinal infection caused by Salmonella enteritidis, the child presented with lesions resembling impetigo contagiosa on the legs and face. Following antibiotic treatment with cephalosporins p.o. and flucloxacillin i.v. she developed typical symptoms of CBDC, i.e. tense blisters on erythematous skin in the perineal area, on the flexor aspects of the thighs and upper arms and on the face. Direct immunofluorescence revealed a linear IgA deposition along the basement membrane zone, confirming the diagnosis of CBDC. These lesions cleared rapidly after treatment with dapsone p.o. This case prompted us to consider new aspects of the pathogenesis, clinical entity and treatment of this rare bullous disease of childhood.
Simon
J C
JC
Universitäts-Hautklinik, Freiburg.
Dietrich
A
A
Kapp
A
A
Schöpf
E
E
D000900:Anti-Bacterial Agents / Q000627:therapeutic use; D001485:Basement Membrane / Q000276:immunology / Q000473:pathology; D002675:Child, Preschool; D015932:Complement C3c / Q000032:analysis; D003622:Dapsone / Q000627:therapeutic use; D003937:Diagnosis, Differential; D005260:Female; D005455:Fluorescent Antibody Technique; D005759:Gastroenteritis / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D006801:Humans; D007105:Immune Complex Diseases / Q000188:drug therapy / Q000276:immunology / Q000473:pathology; D007070:Immunoglobulin A / Q000032:analysis; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D012480:Salmonella Infections / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*; D012477:Salmonella enteritidis / Q000276:immunology; D012867:Skin / Q000276:immunology / Q000473:pathology; D012872:Skin Diseases, Vesiculobullous / Q000188:drug therapy / Q000276:immunology / Q000473:pathology*
D000900:Anti-Bacterial Agents; D007070:Immunoglobulin A; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D015932:Complement C3c; D003622:Dapsone
Chronisch bullöse Dermatose des Kindesalters. Assoziation mit einer Salmonellen-Enteritis.