Coumarins and anti-platelet aggregation constituents from Zanthoxylum schinifolium.
Six new coumarins, schinicoumarin, acetoxyaurapten, epoxycollinin, schininallylol, schinilenol and schinindiol, along with seven known coumarins, aurapten, collinin, epoxyaurapten, hydrangetin, umbelliferone, acetoxycollinin and aesculetin dimethyl ether, three known alkaloids, norchelerythrine, dictamnine and skimmianine, and two triterpenoids, beta-amyrin and friedelin, were isolated and characterized from the chloroform-soluble part of the bark of Zanthoxylum schinifolium. The structures of these compounds were elucidated by spectral analyses. Separation accompanied by bioassay-guided fractionation resulted in the isolation of seven compounds with strong inhibitory activity on platelet aggregation in vitro. These are schinicoumarin, acetoxyaurapten, schininallylol, aurapten, collinin, (-)-acetoxycollinin and dictamnine.
Chen
I S
IS
Graduate Institute of Pharmaceutical Sciences, Kaohsiung Medical College, Taiwan, R.O.C.
Lin
Y C
YC
Tsai
I L
IL
Teng
C M
CM
Ko
F N
FN
Ishikawa
T
T
Ishii
H
H
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000502:physiology*; D003374:Coumarins / Q000302:isolation & purification* / Q000494:pharmacology; D010944:Plants / Q000737:chemistry*; D010974:Platelet Aggregation / Q000187:drug effects*; D010975:Platelet Aggregation Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D011817:Rabbits; D013329:Structure-Activity Relationship
D003374:Coumarins; D010975:Platelet Aggregation Inhibitors