Public health assessment for dioxins exposure from soil.
Dioxins are among the most toxic anthropogenic chemicals in the environment. Their toxicity has been extensively studied in both humans and animals. Dioxin-contaminated soil may result in dioxins occurring in a food chain. This is especially important for the general population. It has been estimated that about 98% of exposure to dioxins is through the oral route. In the 1980s, a concentration level of 1 ppb 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in soil was specified as "a level of concern," based on cancer effects. However, recent studies indicate that end points other than cancer are also of concern. A health risk analysis scenario based on health effects of TCDD other than cancer is discussed and compared with the projected intake from 1 ppb TCDD in soil.
Pohl
H
H
Division of Toxicology, U.S. Department of Health and Human Services, Atlanta, Georgia 30333, USA.
DeRosa
C
C
Holler
J
J
D001682:Biological Availability; D002648:Child; D002675:Child, Preschool; D004147:Dioxins / Q000009:adverse effects*; D004781:Environmental Exposure / Q000331:legislation & jurisprudence; D005506:Food Contamination; D017408:Guidelines as Topic; D006801:Humans; D000072317:Polychlorinated Dibenzodioxins / Q000009:adverse effects; D011634:Public Health / Q000592:standards*; D018570:Risk Assessment; D012989:Soil Pollutants / Q000009:adverse effects*; D014481:United States; D014484:United States Environmental Protection Agency; D014486:United States Food and Drug Administration; D014944:World Health Organization
D004147:Dioxins; D000072317:Polychlorinated Dibenzodioxins; D012989:Soil Pollutants