Effect of saiko-ka-ryukotsu-borei-to on the stress-induced increase of serum corticosterone in mice.
The effect of Saiko-ka-ryukotsu-borei-to (SRBT) on the stress-induced enhancement of serum corticosterone in various stress models was investigated in mice. The serum corticosterone was elevated significantly by immobilized stress, forced-swim stress, electric-shock stress, psychological stress and conditioned-fear stress, respectively. The concentration in the last two models was decreased in a dose-dependent manner by pre-administration of SRBT (10, 60, 100, 600 and 1000 mg/kg, p.o.). Therefore, this action seems to be effective in stress involving emotional factors but ineffective in physical stress models. These results indicate that the anti-stress effect of SRBT is dependent strongly on the degree of psychological change compared with physical change in mice.
Sasaki
K
K
Tohoku College of Pharmacy, Sendai, Japan.
Suzuki
K
K
Yoshizaki
F
F
Ando
T
T
D000818:Animals; D003213:Conditioning, Psychological; D003345:Corticosterone / Q000097:blood*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000032:analysis / Q000494:pharmacology*; D004597:Electroshock; D005239:Fear / Q000502:physiology; D007103:Immobilization; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D013312:Stress, Physiological / Q000097:blood*; D013315:Stress, Psychological / Q000097:blood; D013550:Swimming
D004365:Drugs, Chinese Herbal; C095444:saiko-ka-ryukotsu-borei-to; D003345:Corticosterone