The genetic toxicology of paracetamol and aspirin: a review.
Paracetamol and aspirin are the two most widely used analgesics available for human use without prescription in several parts of the world. Paracetamol has an antipyretic activity, and aspirin has both antipyretic and anti-inflammatory activities. Characterization of the mutagenicity and clastogenicity of these drugs is essential for their overall safety assessment. In the present review, an attempt is made to evaluate the genotoxic effects of these two widely used analgesics based on available literature.
Giri
A K
AK
Division of Toxicology, Central Drug Research Institute, Lucknow, India.
D000082:Acetaminophen / Q000633:toxicity*; D000818:Animals; D001241:Aspirin / Q000633:toxicity*; D002478:Cells, Cultured; D004926:Escherichia coli / Q000235:genetics; D006801:Humans; D009153:Mutagens / Q000633:toxicity*; D009154:Mutation; D012486:Salmonella typhimurium / Q000235:genetics
D009153:Mutagens; D000082:Acetaminophen; D001241:Aspirin