Insulin activates glycogen synthase by a novel PI 3-kinase/p70s6k dependent pathway in 3T3-L1 adipocytes.
Shepherd
P R
PR
Dept of Clinical Biochemistry, University of Cambridge, Addenbrookes Hospital.
Navé
B T
BT
Siddle
K
K
D016475:3T3 Cells; D017667:Adipocytes / Q000187:drug effects / Q000201:enzymology*; D000730:Androstadienes / Q000494:pharmacology; D000818:Animals; D001692:Biological Transport / Q000187:drug effects; D004789:Enzyme Activation; D005947:Glucose / Q000378:metabolism; D006006:Glycogen Synthase / Q000378:metabolism*; D007328:Insulin / Q000494:pharmacology*; D007329:Insulin Antagonists / Q000494:pharmacology; D007700:Kinetics; D051379:Mice; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor) / Q000378:metabolism*; D017346:Protein Serine-Threonine Kinases / Q000378:metabolism*; D019893:Ribosomal Protein S6 Kinases; D014532:Uridine Diphosphate Glucose / Q000378:metabolism; D000077191:Wortmannin
D000730:Androstadienes; D005947:Glucose; D006006:Glycogen Synthase; D007328:Insulin; D007329:Insulin Antagonists; D019869:Phosphatidylinositol 3-Kinases; D017853:Phosphotransferases (Alcohol Group Acceptor); D017346:Protein Serine-Threonine Kinases; D019893:Ribosomal Protein S6 Kinases; D014532:Uridine Diphosphate Glucose; D000077191:Wortmannin