Localization of proteinase expression in the developing rabbit brain.
In developing rabbit brain we studied expression of metalloproteinases (MMP) 1 and 3 by in situ hybridization and MMP2 and tissue and urokinase-type plasminogen activators (tPA and uPA) by immunohistochemistry. All are detected in developing cell populations. Mature olfactory bulb neurons express MMP1 and MMP3. uPA is expressed by glial cells during myelination and by mature cortical neurons. MMP2 is expressed by mature subpial and perivascular astrocytes.
Del Bigio
M R
MR
INSERM U134, Hôpital de la Salpêtrière, Paris, France.
Jacque
C M
CM
D000375:Aging / Q000378:metabolism*; D000818:Animals; D001921:Brain / Q000196:embryology* / Q000201:enzymology*; D010450:Endopeptidases / Q000378:metabolism*; D005333:Fetus / Q000378:metabolism*; D007150:Immunohistochemistry; D017403:In Situ Hybridization; D008666:Metalloendopeptidases / Q000378:metabolism; D011817:Rabbits; D014018:Tissue Distribution; D010959:Tissue Plasminogen Activator / Q000378:metabolism; D014568:Urokinase-Type Plasminogen Activator / Q000378:metabolism
D010450:Endopeptidases; D010959:Tissue Plasminogen Activator; D014568:Urokinase-Type Plasminogen Activator; D008666:Metalloendopeptidases