A monoclonal antibody which blocks infection with feline immunodeficiency virus identifies a possible non-CD4 receptor.
Monoclonal antibody vpg15 detects a 24-kDa cell surface protein on feline cells permissive for infection with feline immunodeficiency virus (FIV). The antibody blocks infection of FIV-susceptible cells, and expression of the vpg15 marker is decreased in FIV-infected cells in vitro. These results suggest that the antibody may recognize an FIV receptor distinct from CD4.
Hosie
M J
MJ
Department of Veterinary Pathology, University of Glasgow Veterinary School, Bearsden, Scotland.
Willett
B J
BJ
Dunsford
T H
TH
Jarrett
O
O
Neil
J C
JC
D000818:Animals; D000911:Antibodies, Monoclonal / Q000276:immunology*; D015704:CD4 Antigens / Q000276:immunology*; D002478:Cells, Cultured; D000939:Epitopes / Q000276:immunology; D016089:Immunodeficiency Virus, Feline / Q000254:growth & development*; D016180:Lentivirus Infections / Q000276:immunology*; D011991:Receptors, Virus / Q000276:immunology*
D000911:Antibodies, Monoclonal; D015704:CD4 Antigens; D000939:Epitopes; D011991:Receptors, Virus