[Pathological and immunohistochemical studies on primary nasal mucosal malignant melanoma].
The pathological and immunohistochemical features of primary nasal mucosal malignant melanoma (PNMMM) were reported in 40 cases. The results showed that approximate 70% of PNMMM was polypoid. The principal features were the mixed existance of different cellular patterns and morphologies. Immunohistochemically, PNMMM reactivity to S-100 protein and vimentin was 90% and 77.5%, respectively, along with no reactivity to Keratin. We believe that PNMMM may arise from preexistant melocytes in nasal mucosa. Histological pleomorphism and immunohistochemical reactivity to S-100 protein and vimentin were of importance for diagnosis of PNMMM, especially for the amelanotic type.
Xu
J
J
First Affiliated Hospital, Wenzhou Medical College.
Chen
L
L
Wang
P
P
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D005260:Female; D006801:Humans; D007150:Immunohistochemistry; D008297:Male; D008545:Melanoma / Q000737:chemistry / Q000473:pathology*; D008875:Middle Aged; D009297:Nasal Mucosa / Q000737:chemistry / Q000473:pathology*; D009669:Nose Neoplasms / Q000737:chemistry / Q000473:pathology*; D012189:Retrospective Studies; D009418:S100 Proteins / Q000378:metabolism; D014746:Vimentin / Q000378:metabolism
D009418:S100 Proteins; D014746:Vimentin