Aplysillin A, a thrombin receptor antagonist from the marine sponge Aplysina fistularis fulva.
Aplysillin A [1], an unusual disulfate ester of a 1,4-diphenyl-1,3-butadiene, was isolated from a deep water specimen of a sponge of the genus Aplysina. Its structure was determined through spectroscopic methods. The compound weakly inhibited binding to the thrombin receptor with an IC50 value of 20 microM.
Gulavita
N K
NK
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Fort Pierce, Florida 34946, USA.
Pomponi
S A
SA
Wright
A E
AE
Garay
M
M
Sills
M A
MA
D000818:Animals; D001792:Blood Platelets / Q000187:drug effects / Q000378:metabolism; D002462:Cell Membrane / Q000187:drug effects / Q000378:metabolism; D006801:Humans; D066298:In Vitro Techniques; D007457:Iodine Radioisotopes; D009682:Magnetic Resonance Spectroscopy; D008745:Methylation; D010636:Phenols / Q000302:isolation & purification* / Q000494:pharmacology; D011161:Porifera / Q000737:chemistry*; D018179:Receptors, Thrombin / Q000037:antagonists & inhibitors*; D013463:Sulfuric Acid Esters / Q000302:isolation & purification* / Q000494:pharmacology
D007457:Iodine Radioisotopes; D010636:Phenols; D018179:Receptors, Thrombin; D013463:Sulfuric Acid Esters; C095623:aplysillin A