title: Proteases and collagenases of Porphyromonas gingivalis.
abstract: Proteases expressed by Porphyromonas gingivalis have been considered as potential virulence factors for these periodontopathic micro-organisms. The introduction of molecular genetic approaches to study these enzymes has clearly demonstrated that these organisms are capable of expressing multiple distinct proteases. Several of these enzymes are apparently expressed as active proteolytic products following processing of larger precursor proteins. In addition, more recent data have suggested a close relationship between some of these enzymes and two other potential virulence factors of these organisms: hemagglutinins and collagenases.
authors.affiliation: Department of Oral Biology, State University of New York, Buffalo 14214, USA.
authors.forename: H K
authors.initials: HK
authors.lastname: Kuramitsu
authors.forename: M
authors.initials: M
authors.lastname: Yoneda
authors.forename: T
authors.initials: T
authors.lastname: Madden
mesh_terms: D001426:Bacterial Proteins / Q000235:genetics / Q000378:metabolism*; D017364:Collagenases / Q000235:genetics / Q000378:metabolism*; D003546:Cysteine Endopeptidases / Q000235:genetics / Q000378:metabolism; D010450:Endopeptidases / Q000235:genetics / Q000378:metabolism*; D015870:Gene Expression; D005798:Genes, Bacterial; D006388:Hemagglutinins / Q000235:genetics / Q000378:metabolism; D016966:Porphyromonas gingivalis / Q000201:enzymology* / Q000235:genetics / Q000472:pathogenicity; D014774:Virulence
chemical_list: D001426:Bacterial Proteins; D006388:Hemagglutinins; D010450:Endopeptidases; D003546:Cysteine Endopeptidases; D017364:Collagenases