title: Eukaryotic DNA replication.
abstract: Recent discoveries suggest that the initiation of eukaryotic DNA replication involves at least two steps--one occurring near the completion of mitosis and the other at the onset of S phase--that bring about the ordered assembly of initiator proteins at the origin. The identification and characterization of components involved in promoting or antagonizing each of these steps has provided a preliminary understanding of how replication initiation is regulated so precisely during the cell cycle.
authors.affiliation: Department of Biochemistry, University of California, San Francisco 94143-0448, USA.
authors.forename: T A
authors.initials: TA
authors.lastname: Wang
authors.forename: J J
authors.initials: JJ
authors.lastname: Li
mesh_terms: D000818:Animals; D001483:Base Sequence; D004261:DNA Replication; D004271:DNA, Fungal / Q000235:genetics; D005057:Eukaryotic Cells; D005800:Genes, Fungal; D005819:Genetic Markers; D006801:Humans; D008954:Models, Biological; D008969:Molecular Sequence Data; D012441:Saccharomyces cerevisiae / Q000235:genetics / Q000378:metabolism
chemical_list: D004271:DNA, Fungal; D005819:Genetic Markers