Frequency of hyperprolactinaemia due to large molecular weight prolactin (150-170 kD PRL).
Of 605 hyperprolactinaemic sera (prolactin > 1000 mU l-1 determined with PRL DELFIA, Wallac) in the routine diagnostic (PRL was measured in 10,737 sera) 26% had an increased amount of PRL with molecular weight (MW) = 150-170 kD (150-170 kD PRL or bigbig PRL). In a series of serum samples from 660 healthy subjects, only one female with hyperprolactinaemia due to increased 150-170 kD PRL was found. The 150-170 kD PRL constituted less than 1% of the total PRL found in 11 patients with prolactinoma (macroprolactinoma, PRL 8800-500,000 mU l-1). When determined with five different commercially available immunometric assays, the PRL values in the sera with large amounts of 150-170 kD were increased in all sera in four of five assays, although they varied widely. The clinical implications of hyperprolactinaemia due to increased 150-170 kD PRL are still uncertain.
Bjøro
T
T
Hormone Laboratory, Aker University Hospital, Oslo, Norway.
Mørkrid
L
L
Wergeland
R
R
Turter
A
A
Kvistborg
A
A
Sand
T
T
Torjesen
P
P
D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood*; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D011388:Prolactin / Q000097:blood* / Q000737:chemistry; D011863:Radioimmunoassay
D011388:Prolactin