Ifosfamide-induced neurotoxicity: associated symptoms and nursing implications.
OBJECTIVE
To review current understanding of the neurotoxicity associated with ifosfamide administration.


METHODS
Published studies of ifosfamide-induced neurotoxicity, published literature on other causes of neurotoxicity associated with cancer, and a case study.


RESULTS
Ifosfamide-induced neurotoxicity has not been well-described in the nursing literature. To correctly identify ifosfamide-induced neurotoxicity, nurses need to assess the patient's history and neurologic, affective, and cognitive status and implement appropriate nursing interventions.


CONCLUSIONS
Research aimed at accurate identification of ifosfamide-induced neurotoxicity and the most effective nursing interventions is needed.


CONCLUSIONS
Judicious nursing assessment will facilitate differentiation of ifosfamide-induced neurotoxicity from other neurotoxicities associated with cancer and its treatment.
Cain
J W
JW
AMGEN Inc., Pittsburgh, PA, USA.
Bender
C M
CM
D001927:Brain Diseases / Q000139:chemically induced* / Q000175:diagnosis / Q000451:nursing; D003072:Cognition Disorders / Q000139:chemically induced / Q000175:diagnosis / Q000451:nursing; D005260:Female; D006801:Humans; D007069:Ifosfamide / Q000009:adverse effects* / Q000494:pharmacology / Q000627:therapeutic use; D008875:Middle Aged; D009859:Oncology Nursing; D010051:Ovarian Neoplasms / Q000188:drug therapy
D007069:Ifosfamide