Stratification of rodent carcinogenicity bioassay results to reflect relative human hazard.
Trans-species, multiple site (particularly common site between species), mutagenic rodent carcinogens are less affected by the influences of polymorphic genes than are chemicals inducing more limited carcinogenic effects. Trans-species carcinogens, therefore, should represent a first priority for attention for human health risk.
Tennant
R W
RW
Experimental Carcinogenesis and Mutagenesis Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709.
D000818:Animals; D001681:Biological Assay; D015197:Carcinogenicity Tests; D002273:Carcinogens / Q000145:classification* / Q000633:toxicity*; D006801:Humans; D006824:Hybridization, Genetic; D051379:Mice; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity; D009374:Neoplasms, Experimental / Q000139:chemically induced; D009928:Organ Specificity; D011110:Polymorphism, Genetic; D011237:Predictive Value of Tests; D051381:Rats; D012377:Rodentia; D013045:Species Specificity
D002273:Carcinogens; D009153:Mutagens