Expression of multidrug resistance-associated protein (MRP) in thyroid cancers.
It was found that the mechanism of anti-cancer drug resistance in anaplastic carcinoma of the thyroid was not explicable only in terms of expression of mdr1 and its gene product, P-glycoprotein. The multidrug resistance-associated protein (MRP), another member of the mdr gene family, may be involved in anti-cancer drug resistance of this carcinoma. The MRP expression was examined immunohistochemically in 8 cell lines and 73 thyroid cancer tissues; its frequency in anaplastic carcinoma (52%) was significantly higher than that in other thyroid cancer types.
Sugawara
I
I
Department of Pathology, Saitama Medical Center, Saitama Medical School, Japan.
Masunaga
A
A
Itoyama
S
S
Sumizawa
T
T
Akiyama
S
S
Yamashita
T
T
D018528:ATP-Binding Cassette Transporters / Q000378:metabolism*; D000595:Amino Acid Sequence; D002277:Carcinoma / Q000378:metabolism*; D018432:Drug Resistance, Multiple; D006801:Humans; D007150:Immunohistochemistry; D008969:Molecular Sequence Data; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D010455:Peptides / Q000737:chemistry; D013964:Thyroid Neoplasms / Q000378:metabolism*
D018528:ATP-Binding Cassette Transporters; D027425:ATP-Binding Cassette, Sub-Family C Proteins; D010455:Peptides