title: The use of controlled-release morphine sulfate (MS Contin) in Queensland 1990-1993.
abstract: OBJECTIVE
  To investigate the use of controlled-release morphine sulfate (MS Contin, Pharmacia) in Queensland, 1990-1993.
  
  
  METHODS
  Records of 434 patients notified to the Drugs of Dependence Unit (DDU) for prolonged use of MS Contin (as at 16 August 1993) were analysed, the information was verified, and the patients' diagnoses were coded (ICD-9). Estimates of daily drug consumption were calculated from computerised prescription data.
  
  
  RESULTS
  Controlled-release morphine sulfate was being used for indications other than its licensed indication "chronic severe pain of cancer": 39.9% of the patients received the drug for non-malignant conditions. The dose escalation for patients with non-malignant conditions was significantly less than that of the patients with malignant conditions (P = 0.002).
  
  
  CONCLUSIONS
  Despite controversy about the use of controlled-release morphine sulfate for chronic pain of non-malignant origin, its use is widespread.
authors.affiliation: Environmental Health Branch, Queensland Health, Brisbane.
authors.forename: A H
authors.initials: AH
authors.lastname: Richards
mesh_terms: D000368:Aged; D002908:Chronic Disease; D003692:Delayed-Action Preparations; D004363:Drug Utilization; D006801:Humans; D008297:Male; D008875:Middle Aged; D009020:Morphine / Q000008:administration & dosage*; D009369:Neoplasms / Q000150:complications; D010146:Pain / Q000188:drug therapy* / Q000209:etiology; D011793:Queensland
chemical_list: D003692:Delayed-Action Preparations; D009020:Morphine