A controlled study on serum insulin-like growth factor-I and urinary excretion of growth hormone in fibromyalgia.
OBJECTIVE
It has been hypothesized that secretory deficiencies of growth hormone may play a pathophysiological role in fibromyalgia (FM). Our objective was thus to evaluate the secretion of growth hormone in FM.


METHODS
The 24-h urinary growth hormone excretion and serum levels of insulin-like growth factor-I (IGF-I) was measured in 17 middle aged women with FM and 19 healthy women. The degree of subjective sleep disturbance was also determined.


RESULTS
Sleep was significantly more disturbed in the patients than the controls. We found no significant differences in the urinary excretion of growth hormone and serum levels of IGF-I between patients with FM and healthy controls.


CONCLUSIONS
Major secretory deficiencies were not documented. However, the power of our study does not allow us to discard the role of minor secretory deficiencies of human growth hormone in FM.
Jacobsen
S
S
Department of Rheumatology, Hvidovre Hospital, University of Copenhagen, Denmark.
Main
K
K
Danneskiold-Samsøe
B
B
Skakkebaek
N E
NE
D000328:Adult; D002940:Circadian Rhythm; D005260:Female; D005356:Fibromyalgia / Q000097:blood* / Q000150:complications / Q000652:urine*; D013006:Growth Hormone / Q000652:urine*; D006801:Humans; D007334:Insulin-Like Growth Factor I / Q000378:metabolism*; D008875:Middle Aged; D012016:Reference Values; D012893:Sleep Wake Disorders / Q000209:etiology
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone