title: Adult respiratory distress syndrome following closure of a chronic ventricular septal defect: possible relationship to the use of intracardiac gelatin-resorcin-formaldehyde glue.
abstract: Gelatin-resorcin-formaldehyde glue is now widely used in cardiac surgery, particularly in Europe. A case is reported where its use may have contributed to the pulmonary dysfunction seen postoperatively after elective closure of a postinfarct ventricular septal defect. It is believed that this is a result of a relatively high exposure of the pulmonary circulation to the glue, in particular to formalin. Although not proven, the authors advise caution when using the glue within the cardiac chambers.
authors.affiliation: Department of Cardiothoracic Surgery, St Thomas' Hospital, London, UK.
authors.forename: U H
authors.initials: UH
authors.lastname: Trivedi
authors.forename: J J
authors.initials: JJ
authors.lastname: Black
authors.forename: C
authors.initials: C
authors.lastname: Aps
authors.forename: C P
authors.initials: CP
authors.lastname: Young
mesh_terms: D000368:Aged; D001705:Bioprosthesis; D001807:Blood Vessel Prosthesis; D004338:Drug Combinations; D017809:Fatal Outcome; D005557:Formaldehyde / Q000008:administration & dosage / Q000009:adverse effects*; D005780:Gelatin / Q000008:administration & dosage / Q000009:adverse effects*; D006322:Heart Aneurysm / Q000473:pathology / Q000601:surgery; D006345:Heart Septal Defects, Ventricular / Q000473:pathology / Q000601:surgery*; D006352:Heart Ventricles / Q000473:pathology; D006801:Humans; D008297:Male; D009203:Myocardial Infarction / Q000473:pathology / Q000601:surgery; D011183:Postoperative Complications / Q000139:chemically induced* / Q000473:pathology; D012118:Resorcinols / Q000008:administration & dosage / Q000009:adverse effects*; D012128:Respiratory Distress Syndrome / Q000139:chemically induced* / Q000473:pathology; D014014:Tissue Adhesives / Q000009:adverse effects*
chemical_list: D004338:Drug Combinations; D012118:Resorcinols; D014014:Tissue Adhesives; C027813:gelatin-resorcinol-formaldehyde tissue adhesive; D005557:Formaldehyde; D005780:Gelatin