title: [Regulatory effect of ventral tegmental area on sleep-wakefulness in rats].
abstract: Experiments were performed on 31 male SD rats. The results were as follows: (1) The time of waking was increased during the second and third hours after microinjection of 3.3 and 6.6 nmol bromocriptine into bilateral VTA (P < 0.01), but the 1.33 nmol group was without significant effect. (2) The time of waking was decreased during the second and third hours after microinjection of 2 and 4 nmol SCH23390 into VTA (P < 0.01 and P < 0.05 respectively), while 3.4 nmol sulpiride group was without effect. (3) One week after administration of kainic acid (0.3 microgram), the rats presented less time of waking in the day (P < 0.05), while sleep-wakefulness cycle at night showed no change. The results suggest that bromocriptine could increase wakefulness by activating VTA DA neurons via D1 receptor and that the DA neurons might exert a tonic effect for maintaining the wakefulness at the daytime.
authors.affiliation: Department of Physiology, Shanghai Second Medical University.
authors.forename: W H
authors.initials: WH
authors.lastname: Zhang
authors.forename: Z X
authors.initials: ZX
authors.lastname: Qian
authors.forename: H H
authors.initials: HH
authors.lastname: Wang
authors.forename: K
authors.initials: K
authors.lastname: Cai
authors.forename: Y L
authors.initials: YL
authors.lastname: Lin
mesh_terms: D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D001971:Bromocriptine / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000187:drug effects; D017557:Ventral Tegmental Area / Q000502:physiology*; D014851:Wakefulness / Q000187:drug effects
chemical_list: D001552:Benzazepines; D001971:Bromocriptine; D007608:Kainic Acid