Acetylcholinesterase inhibition by territrem B derivatives.
Five derivatives of territrem B [2], a potent acetylcholinesterase inhibitor isolated from a rice culture of Aspergillus terreus, were prepared from 2 as well as from its major metabolite, 4 beta-hydroxymethyl-4 beta-demethylterritrem B [4]. The inhibitory activities of these derivatives against electric eel acetylcholinesterase (E.C. 3.1.1.7) were tested and it was concluded that the enone and the pyrone groups present in 2 may play an important biological role.
Peng
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FC
Institute of Toxicology, College of Medicine, National Taiwan University, Taipei, Republic of China.
D000818:Animals; D001230:Aspergillus / Q000737:chemistry; D002800:Cholinesterase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology*; D002802:Cholinesterases / Q000378:metabolism; D004593:Electrophorus; D009682:Magnetic Resonance Spectroscopy; D011714:Pyrans / Q000302:isolation & purification* / Q000494:pharmacology*
D002800:Cholinesterase Inhibitors; D011714:Pyrans; C040405:territrem B; D002802:Cholinesterases