[Growth hormone in adults. An elixir of youth?].
Studies have revealed a partial deficiency of growth hormone (GH) secretion in the elderly. Aging has a central effect on the GH secretion and probably a peripheral effect on insulin-like growth factor 1 (IGF-1) or somatomedin C through changes in body composition. Simultaneously therapeutic efficiency of recombinant GH was confirmed in adults with GH deficiency. These notions have led to some controlled trials of GH treatment in elderly. Further studies of GH replacement are needed, examining issues such as dosage, tolerance (still inadequate) and efficacy before the widespread use of GH or IGH-F 1 in the elderly is advocated.
Rainfray
M
M
Service de Gérontologie et de Médecine Interne (F. Piette) Hôpital Charles Foix, Ivry sur Seine, France.
Hamon-Vilcot
B
B
Cnockaert
X
X
Pellerin
J
J
Bouillanne
O
O
Durand
D
D
Piette
F
F
D000328:Adult; D000375:Aging; D005260:Female; D013006:Growth Hormone / Q000097:blood / Q000378:metabolism / Q000627:therapeutic use*; D006801:Humans; D007030:Hypothalamo-Hypophyseal System / Q000378:metabolism; D007334:Insulin-Like Growth Factor I / Q000172:deficiency / Q000627:therapeutic use*; D008297:Male
D007334:Insulin-Like Growth Factor I; D013006:Growth Hormone
L'hormone de croissance chez l'adulte. Un élixir de jouvence?