title: Delayed-type hypersensitivity to human gonadotropin: case report.
abstract: OBJECTIVE
  To investigate adverse reactions to hMG preparations in two women in IVF programs.
  
  
  METHODS
  Two case reports with skin tests for delayed hypersensitivity (DH) to hMG and a biopsy of one delayed reaction.
  
  
  METHODS
  Allergy and infertility clinics in university medical center.
  
  
  METHODS
  Two affected patents with a history of local reactions to the injected hMG, one of whom also had fever, and nine control subjects.
  
  
  METHODS
  Skin tests and biopsy.
  
  
  METHODS
  Delayed hypersensitivity skin response to hMG in affected patients indicated by timing and biopsy results. Negative skin test with the purified hFSH, which was also used in treatment with no adverse effects.
  
  
  CONCLUSIONS
  Use of the purified preparation avoids DH reaction.
authors.affiliation: McMaster University, Hamilton, Ontario, Canada.
authors.forename: A
authors.initials: A
authors.lastname: Redfearn
authors.forename: E G
authors.initials: EG
authors.lastname: Hughes
authors.forename: M
authors.initials: M
authors.lastname: O'Connor
authors.forename: J
authors.initials: J
authors.lastname: Dolovich
mesh_terms: D000328:Adult; D001706:Biopsy; D005260:Female; D005307:Fertilization in Vitro; D005640:Follicle Stimulating Hormone / Q000276:immunology / Q000302:isolation & purification / Q000627:therapeutic use; D006801:Humans; D006968:Hypersensitivity, Delayed / Q000175:diagnosis / Q000276:immunology*; D008596:Menotropins / Q000276:immunology* / Q000627:therapeutic use; D012867:Skin / Q000473:pathology; D012882:Skin Tests
chemical_list: D008596:Menotropins; D005640:Follicle Stimulating Hormone