Altered serotonin transporter sites in Alzheimer's disease raphe and hippocampus.
This study measured serotonin transporter (5-HTT) sites in the dorsal raphe nucleus (DRN) and hippocampus in Alzheimer's disease (AD). 5-HTT sites were significantly decreased in the DRN in AD, with significant reductions occurring in the lateral wings of the DRN complex. A significant reduction in 5-HTT sites were also observed in the CA2 subfield of the hippocampus and in the entorhinal cortex in AD. The results indicate that the integrity of 5-HT neurons in the DRN may be compromised in AD, and that region specific alterations in 5-HTT sites may occur in the hippocampal complex in AD.
Tejani-Butt
S M
SM
University of Pennsylvania, Department of Psychiatry, Philadelphia 19104, USA.
Yang
J
J
Pawlyk
A C
AC
D000368:Aged; D000544:Alzheimer Disease / Q000378:metabolism*; D001345:Autoradiography; D001665:Binding Sites; D002352:Carrier Proteins / Q000378:metabolism*; D006624:Hippocampus / Q000378:metabolism*; D006801:Humans; D008562:Membrane Glycoproteins / Q000378:metabolism*; D026901:Membrane Transport Proteins; D008875:Middle Aged; D009419:Nerve Tissue Proteins; D011903:Raphe Nuclei / Q000378:metabolism*; D050486:Serotonin Plasma Membrane Transport Proteins
D002352:Carrier Proteins; D008562:Membrane Glycoproteins; D026901:Membrane Transport Proteins; D009419:Nerve Tissue Proteins; C493230:SLC6A4 protein, human; D050486:Serotonin Plasma Membrane Transport Proteins