The GABAA receptor channel mediated chloride ion translocation through the plasma membrane: new insights from 36Cl- ion flux measurements.
GABAA receptors in plasma membranes of neurons are integral oligomers which form chloride channels. The binding of GABA molecules at recognition sites for channel opening triggers a transient increase in transmembrane chloride ion flux. The multiplicity and drug specificity of GABAA receptor, kinetics of channel opening, and desensitization of GABAA receptor and its short- and long-term regulation have been investigated by the use of tracer amounts of the radioactive chloride isotope, 36Cl- ion. Results and new insights from 36Cl- ion flux measurements have been reviewed.
Kardos
J
J
Department of Pharmacodynamics, Central Research Institute for Chemistry, Hungarian Academy of Sciences, Budapest.
D000818:Animals; D002462:Cell Membrane / Q000378:metabolism; D002712:Chlorides / Q000378:metabolism*; D002713:Chlorine; D006801:Humans; D007473:Ion Channels / Q000502:physiology*; D009474:Neurons / Q000378:metabolism*; D011868:Radioisotopes; D011963:Receptors, GABA-A / Q000502:physiology*
D002712:Chlorides; D007473:Ion Channels; D011868:Radioisotopes; D011963:Receptors, GABA-A; D002713:Chlorine