The stimulatory effect of clonidine on locus coeruleus noradrenergic neurons through imidazoline receptors is modulated by excitatory amino acids.
Pineda
J
J
Department of Pharmacology, University of the Basque Country, Leioa, Bizkaia, Spain.
Ruiz-Ortega
J A
JA
Ugedo
L
L
García-Sevilla
J A
JA
D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D003000:Clonidine / Q000494:pharmacology*; D018846:Excitatory Amino Acids / Q000378:metabolism*; D010134:Fenclonine; D054755:Imidazoline Receptors; D008125:Locus Coeruleus / Q000166:cytology / Q000187:drug effects* / Q000378:metabolism; D008297:Male; D008781:Methyltyrosines; D009474:Neurons / Q000187:drug effects / Q000378:metabolism; D009638:Norepinephrine / Q000378:metabolism*; D011804:Quinolines / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D011955:Receptors, Drug / Q000378:metabolism*; D012110:Reserpine / Q000494:pharmacology; D019805:alpha-Methyltyrosine
D000317:Adrenergic alpha-Antagonists; D018846:Excitatory Amino Acids; D054755:Imidazoline Receptors; D008781:Methyltyrosines; D011804:Quinolines; D011955:Receptors, Drug; C000470:EEDQ; D019805:alpha-Methyltyrosine; D012110:Reserpine; D003000:Clonidine; D010134:Fenclonine; D009638:Norepinephrine