The effect of silicone-gel on the immune response.
Silicone materials have been used in medical applications for at least 30 years. Despite this long history of use the question whether silicones can mediate an immunological reaction that may be detrimental to the host remains unanswered. Most studies on the biocompatability of silicones conclude that silicones are chemically stable compounds, which however are often capable of eliciting a benign chronic inflammatory response. Recently, our laboratory has conducted a series of animal experiments aimed at determining the immunological adjuvancy potential of silicone-gel taken from commercial breast implants. Our previous studies have indicated that silicone-gel is a potent humoral (antibody) adjuvant. Our present studies have found that silicone-gel is capable of eliciting auto-antibodies to rat thyroglobulin and bovine collagen II. However this immune response did not produce any histological evidence of thyroiditis or arthritis. Theories to explain why silicone-gel behaves as an adjuvant are discussed along with discussion of the hypothesis on the desirability of replacing silicone-gel with a more hydrophilic material in bioimplants.
Naim
J O
JO
Department of Surgery, Rochester General Hospital, NY 14621, USA.
Lanzafame
R J
RJ
van Oss
C J
CJ
D000276:Adjuvants, Immunologic; D000818:Animals; D001323:Autoantibodies / Q000096:biosynthesis* / Q000187:drug effects / Q000276:immunology; D001672:Biocompatible Materials / Q000592:standards; D018427:Breast Implants / Q000009:adverse effects; D003094:Collagen / Q000276:immunology; D004195:Disease Models, Animal; D004797:Enzyme-Linked Immunosorbent Assay; D005620:Freund's Adjuvant / Q000008:administration & dosage / Q000009:adverse effects; D006968:Hypersensitivity, Delayed / Q000139:chemically induced*; D007111:Immunity, Cellular / Q000187:drug effects; D008297:Male; D051381:Rats; D017207:Rats, Sprague-Dawley; D012710:Serum Albumin, Bovine / Q000276:immunology; D012827:Silicone Oils / Q000008:administration & dosage / Q000009:adverse effects; D012828:Silicones / Q000009:adverse effects*; D012882:Skin Tests; D013954:Thyroglobulin / Q000276:immunology; D013967:Thyroiditis, Autoimmune / Q000139:chemically induced*
D000276:Adjuvants, Immunologic; D001323:Autoantibodies; D001672:Biocompatible Materials; D012827:Silicone Oils; D012828:Silicones; D012710:Serum Albumin, Bovine; D003094:Collagen; D005620:Freund's Adjuvant; D013954:Thyroglobulin