title: Spiral ganglion cell survival in labyrinthitis ossificans: computerized image analysis.
abstract: Obstruction of the cochlear scale by ossification and fibrosis, which can now be imaged by computed tomography, has been proposed as a predictor of ganglion cell survival. Subjects for this histopathologic temporal bone study were 12 profoundly deaf patients with labyrinthitis ossificans. Controls without ossification were 16 normal-hearing patients and 16 profoundly deaf patients. All temporal bones were graphically reconstructed. Computerized image analysis obtained the percentage of scalar obstruction in 12 temporal bones with labyrinthitis ossificans. Statistical analyses could demonstrate no relationship between spiral ganglion cell survival and obstruction. There was much interindividual variability in ganglion cell count among the 44 temporal bones. Ganglion cell survival was significantly less in the two deafness groups than in the normal group, but did not differ significantly between the two deafness groups. Therefore, cochlear labryinthitis ossificans is not a preditor of ganglion cell survival and should not be a contraindication to cochlear implantation.
authors.affiliation: Section of Otolaryngology-Head and Neck Surgery, University of Chicago, Illinois, USA.
authors.forename: R
authors.initials: R
authors.lastname: Hinojosa
authors.forename: M I
authors.initials: MI
authors.lastname: Redleaf
authors.forename: J D
authors.initials: JD
authors.lastname: Green
authors.forename: R R
authors.initials: RR
authors.lastname: Blough
mesh_terms: D000293:Adolescent; D000328:Adult; D000368:Aged; D002452:Cell Count; D002470:Cell Survival; D002648:Child; D003638:Deafness / Q000209:etiology; D006801:Humans; D007762:Labyrinthitis / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000150:complications / Q000000981:diagnostic imaging / Q000473:pathology*; D013136:Spiral Ganglion / Q000473:pathology*; D013701:Temporal Bone / Q000000981:diagnostic imaging / Q000473:pathology; D014057:Tomography, X-Ray Computed