Comparison of efficacy of two oximes (HI-6 and obidoxime) in soman poisoning in rats.
The action of HI-6 (1-[[[(4-aminocarbonyl)pyridiniol]methoxy]methyl]-2-[ (hydroxyimino)methyl] pyridinium dichloride monohydrate) and obidoxime on soman-induced anticholinesterase and stressogenic effects was studied in rats. HI-6 significantly affected acetylcholinesterase inhibition in erythrocytes, brain and diaphragm and practically eliminated the stressogenic effects of soman, i.e. an increase in plasma corticosterone level and liver tyrosine amino-transferase activity, while obidoxime, on the other hand, had very little influence on soman-induced inhibition of acetylcholinesterase activity and the stressogenic effects of soman. These findings support a hypothesis that the effects of HI-6 are not solely due to reactivation of the enzyme. They also demonstrate its importance in the treatment of soman poisoning in rats.
Kassa
J
J
Purkynĕ Military Medical Academy, Hradec Králové, Czech Republic.
D000110:Acetylcholinesterase / Q000378:metabolism*; D000818:Animals; D000931:Antidotes / Q000627:therapeutic use*; D001921:Brain / Q000187:drug effects / Q000201:enzymology; D002801:Cholinesterase Reactivators / Q000627:therapeutic use*; D003348:Cortisone / Q000097:blood; D005260:Female; D008099:Liver / Q000187:drug effects / Q000201:enzymology; D009768:Obidoxime Chloride / Q000627:therapeutic use*; D010091:Oximes; D011041:Poisoning / Q000188:drug therapy; D011726:Pyridinium Compounds / Q000627:therapeutic use*; D051381:Rats; D017208:Rats, Wistar; D012999:Soman / Q000037:antagonists & inhibitors / Q000506:poisoning*; D014444:Tyrosine Transaminase / Q000378:metabolism
D000931:Antidotes; D002801:Cholinesterase Reactivators; D010091:Oximes; D011726:Pyridinium Compounds; D009768:Obidoxime Chloride; D012999:Soman; D014444:Tyrosine Transaminase; D000110:Acetylcholinesterase; C022870:asoxime chloride; D003348:Cortisone