[Prevention of diarrheal diseases and oral vaccination].
Vaccination against diarrhoeal diseases has been set up as a primary goal for developing countries. Recent progress in understanding the molecular and cellular bases of these infections and the function of the mucosal immune system opens the way to new strategies of vaccination. Mucosal surfaces, particularly the intestine, appear as suitable targets for a new generation of vaccines among which live attenuated vectors are promising. However, we are still a long way from mastering all the relevant parameters of such approaches.
Sansonetti
P J
PJ
Unité de pathogénie microbienne moléculaire INSERM U 389, Institut Pasteur, Paris.
D000284:Administration, Oral; D003967:Diarrhea / Q000276:immunology / Q000628:therapy*; D006801:Humans; D014613:Vaccines, Attenuated / Q000008:administration & dosage* / Q000627:therapeutic use
D014613:Vaccines, Attenuated
Prévention des maladies diarrhéiques et vaccination orale.