Effect of compression temperature on the consolidation mechanism of chlorpropamide polymorphs.
The effect of environmental temperature on the compression mechanism of chlorpropamide (CPM) polymorph, forms A and C, was investigated with an eccentric type tabletting machine with two load cells and a noncontact displacement transducer. The temperature of the die was controlled at 0 and 45 degrees C by a thermocontroller. Sample powders (200 mg), which were also controlled at 0 and 45 degrees C by a thermocontroller, were compressed at almost 230 MPa. The tabletting dynamic processes of CPM forms A and C at 0 and 45 degrees C were evaluated by Cooper and modified Heckel analyses. The results suggest that particle brittleness or plasticity was affected by compression at different temperatures. The higher tablet hardness of form A at 45 degrees C was thought to be caused by the increased plasticity of primary particles, whereas that of form C at 45 degrees C was ascribed to the decreased size of the secondary particles.
Otsuka
M
M
Department of Pharmaceutical Technology, Kobe Pharmaceutical University, Japan.
Matsumoto
T
T
Higuchi
S
S
Otsuka
K
K
Kaneniwa
N
N
D002626:Chemistry, Pharmaceutical; D002747:Chlorpropamide / Q000737:chemistry*; D007259:Infrared Rays; D008433:Mathematics; D010316:Particle Size; D011208:Powders; D011312:Pressure; D013696:Temperature; D014965:X-Rays
D011208:Powders; D002747:Chlorpropamide