Chemical mixtures exposure and children's health.
Studies to examine the health of the children with compromised immune and endocrine systems living in different air polluted regions by oil waste were undertaken. A dose-dependent effects of the anthropogenic pollution on the functional immunocompetent cells activity, mainly T-suppressors was observed as well as stimulation of immunoglobulins synthesis and reduction of phagocytic activity of neutrophils. Disconnection of immunoglobulins synthesis with production of high specifity antibodies, antiviral in particular, was registered. Correlation changes between indices of hormonal activity and humoral specific defence leading to an increase in the role of peripheral hormones with immune inhibitory effect were revealed. The informative value of studied indices as environmental pollution bioindicators was considered. They will stimulate further investigations in biomonitoring and its introduction into practice of ecological expertise of dwelling agglomerations.
Etkina
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Bashkir Medical Institute, Department of Children's Diseases, Ufa, Bashkortostan, Russia.
Etkina
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IA
D000393:Air Pollutants / Q000009:adverse effects*; D002319:Cardiovascular System / Q000187:drug effects / Q000473:pathology; D002493:Central Nervous System Diseases / Q000139:chemically induced; D002648:Child; D002669:Child Welfare; D002675:Child, Preschool; D015331:Cohort Studies; D004064:Digestive System / Q000187:drug effects / Q000473:pathology; D004305:Dose-Response Relationship, Drug; D004427:Ear Diseases / Q000139:chemically induced; D004702:Endocrine Glands / Q000187:drug effects / Q000473:pathology; D004781:Environmental Exposure; D005260:Female; D006256:Hazardous Waste / Q000009:adverse effects*; D006728:Hormones / Q000097:blood; D006801:Humans; D007107:Immune System / Q000187:drug effects / Q000473:pathology; D007136:Immunoglobulins / Q000097:blood; D008297:Male; D009821:Oils / Q000009:adverse effects*; D010038:Otorhinolaryngologic Diseases / Q000139:chemically induced; D011863:Radioimmunoassay; D013601:T-Lymphocytes / Q000187:drug effects
D000393:Air Pollutants; D006256:Hazardous Waste; D006728:Hormones; D007136:Immunoglobulins; D009821:Oils