Follow-up of 30 pregnancies after embryo cryopreservation.
OBJECTIVE
In an observational follow-up study, the pregnancy outcome of the first 30 women who conceived after transfer of cryopreserved embryos was evaluated.


METHODS
The main outcome measures were duration and complications of pregnancy, mode of delivery, complications during and after childbirth, birthweight, Apgar score, and congenital anomalies.


RESULTS
Twenty-six pregnancies ended in birth of one (n = 22) or more (n = 4) infants with a cesarean section rate of 23%. Of the singleton pregnancies 77% were uncomplicated, but there was a high incidence of breech presentation (14%). Infant birthweight tended to be above average with 45% of singletons weighing more than the 75th centile of weight for gestation. There were no major congenital deformations.


CONCLUSIONS
The results of our embryo cryopreservation program are encouraging, but sustained follow-up of such pregnancies and infants is needed.
Heijnsbroek
I
I
Department of Obstetrics, Gynecology and Reproductive Medicine, Leiden University Hospital, The Netherlands.
Helmerhorst
F M
FM
van den Berg-Helder
A F
AF
van der Zwan
K J
KJ
Naaktgeboren
N
N
Keirse
M J
MJ
D000328:Adult; D001034:Apgar Score; D001724:Birth Weight; D000013:Congenital Abnormalities / Q000453:epidemiology; D015925:Cryopreservation / Q000592:standards*; D004624:Embryo Transfer / Q000592:standards*; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D015994:Incidence; D007231:Infant, Newborn; D008297:Male; D009426:Netherlands / Q000453:epidemiology; D011247:Pregnancy; D011248:Pregnancy Complications / Q000453:epidemiology; D011256:Pregnancy Outcome / Q000453:epidemiology*