title: An angiotensin-converting enzyme gene variant is associated with acute myocardial infarction in women but not in men.
abstract: We believe our data may speak to the issue of sexual dimorphism with respect to MI. Most studies have concentrated on men with this disease. In a recent study, Lindpaintner et al10 could find no relationship between the D/D genotype and AMI in subjects of the Physicians Health Study. However, this study consisted entirely of men. The D allele may provide an avenue to discern differences in the pathogenesis of MI in men and women.
authors.affiliation: Franz Volhard Clinic, Berlin, Germany.
authors.forename: H
authors.initials: H
authors.lastname: Schuster
authors.forename: T F
authors.initials: TF
authors.lastname: Wienker
authors.forename: U
authors.initials: U
authors.lastname: Stremmler
authors.forename: B
authors.initials: B
authors.lastname: Noll
authors.forename: A
authors.initials: A
authors.lastname: Steinmetz
authors.forename: F C
authors.initials: FC
authors.lastname: Luft
mesh_terms: D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D005260:Female; D005796:Genes; D014644:Genetic Variation; D005838:Genotype; D006801:Humans; D008297:Male; D008875:Middle Aged; D009203:Myocardial Infarction / Q000175:diagnosis / Q000235:genetics*; D007703:Peptidyl-Dipeptidase A / Q000235:genetics*; D011110:Polymorphism, Genetic; D012727:Sex Characteristics
chemical_list: D007703:Peptidyl-Dipeptidase A