title: [Protein subunit vaccines: example of vaccination against hepatitis B virus].
abstract: Hepatitis B vaccine has been used for over 10 years. It is efficient and safe. Protection of risk groups against hepatitis B virus infection is now achieved and vaccination of newborns and adolescents is a main public health problem. Bad responders are well characterized and immunomodulatory interventions (cytokines) must be tested in these patients. Response to hepatitis B vaccine is genetically determined and the possibility of vaccine induced escape mutants should lead to careful epidemiological studies of the spread of hepatitis B virus infection.
authors.affiliation: Service d'hépatologie Hôpital Beaujon, Clichy.
authors.forename: F
authors.initials: F
authors.lastname: Degos
mesh_terms: D017325:Hepatitis B Vaccines / Q000145:classification / Q000276:immunology; D006515:Hepatitis B virus / Q000235:genetics; D006801:Humans; D016867:Immunocompromised Host; D009154:Mutation; D014611:Vaccination / Q000379:methods
chemical_list: D017325:Hepatitis B Vaccines
vernacular_title: Vaccins sous-unités protéiques: exemple de la vaccination contre le virus de l'hépatite B.