title: Effect of deferoxamine-hydroxyethyl pentafraction starch on free, autogenous full-thickness skin grafts in dogs.
abstract: Free, autogenous, full-thickness skin grafting was performed on 10 dogs; 5 dogs were given an iron chelator, deferoxamine-10% hydroxyethyl pentafraction starch (DEF-HES; 50 mg/kg of body weight, IV), and 5 dogs were given 10% hydroxyethyl pentafraction starch (HES) in 0.9% saline solution (5 ml/kg, IV). The percentage of viable graft on day 10 was higher, but not significantly so, in DEF-HES-treated dogs (mean +/- SD, 72.6 +/- 24.8%; median 76.5%) than in HES-treated dogs (mean +/- SD, 46.7 +/- 34.3%; median, 48.8%). A trend for a positive correlation between the percentage of viable graft (on day 10) and the percentage of original graft area (on day 28) was observed in HES- and DEF-HES-treated dogs; this trend was significant in HES-treated dogs (P = 0.012). Both groups had significant positive correlation between percentage of viable graft on day 10 and percentage of haired skin on day 28 (HES, P = 0.000002; DEF-HES, P = 0.0148). A unique finding in DEF-HES treated dogs was the consistent observation of foamy macrophages in the dermis adjacent to the grafts, in deep subcutaneous tissue below the grafts, and in normal dermis.
authors.affiliation: Department of Veterinary Clinical Sciences, Louisiana State University, Baton Rouge 70803.
authors.forename: G
authors.initials: G
authors.lastname: Hosgood
authors.forename: D D
authors.initials: DD
authors.lastname: Lewis
authors.forename: E C
authors.initials: EC
authors.lastname: Hodgin
authors.forename: D F
authors.initials: DF
authors.lastname: Church
authors.forename: M K
authors.initials: MK
authors.lastname: Lopez
mesh_terms: D000818:Animals; D003676:Deferoxamine / Q000494:pharmacology*; D004285:Dogs / Q000601:surgery*; D006085:Graft Survival / Q000187:drug effects*; D006895:Hydroxyethyl Starch Derivatives / Q000494:pharmacology*; D016038:Skin Transplantation / Q000473:pathology / Q000662:veterinary*
chemical_list: D006895:Hydroxyethyl Starch Derivatives; C068460:hydroxyethyl starch-deferoxamine conjugate; D003676:Deferoxamine