title: Effect of an ACTH(4-9) analogue on cisplatin neuropathy of longstanding duration: a phase II study.
abstract: The efficacy of Org 2766, an ACTH(4-9) analogue, on the recovery of cisplatin neuropathy of longstanding duration was investigated in a phase II study. Twenty-two patients were treated with Org 2766 during a period of 4 months and vibration perception threshold (VPT) and sum scores for neuropathic symptoms and signs were compared with pre-treatment values. No change in VPT could be detected. Although there was a small improvement of clinical measures for neuropathy, no clear evidence for repair could be obtained. These results indicate no beneficial effect of Org 2766 on recovery of a longstanding cisplatin neuropathy.
authors.affiliation: Department of Neuro-Oncology, Dr. Daniel den Hoed Cancer Center and University Hospital, Rotterdam, Netherlands.
authors.forename: P H
authors.initials: PH
authors.lastname: Hilkens
authors.forename: M E
authors.initials: ME
authors.lastname: van der Burg
authors.forename: J W
authors.initials: JW
authors.lastname: Moll
authors.forename: M J
authors.initials: MJ
authors.lastname: van den Bent
authors.forename: W L
authors.initials: WL
authors.lastname: van Putten
authors.forename: C J
authors.initials: CJ
authors.lastname: Vecht
mesh_terms: D000324:Adrenocorticotropic Hormone / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000627:therapeutic use; D000328:Adult; D000368:Aged; D000927:Anticonvulsants; D001927:Brain Diseases / Q000188:drug therapy* / Q000209:etiology* / Q000503:physiopathology; D002945:Cisplatin / Q000008:administration & dosage / Q000009:adverse effects* / Q000627:therapeutic use*; D005260:Female; D006801:Humans; D008297:Male; D008875:Middle Aged; D009039:Motion Perception; D009369:Neoplasms / Q000188:drug therapy*; D010446:Peptide Fragments / Q000008:administration & dosage / Q000627:therapeutic use*; D011446:Prospective Studies; D016896:Treatment Outcome; D014732:Vibration
chemical_list: D000927:Anticonvulsants; D010446:Peptide Fragments; C013765:Org 2766; D000324:Adrenocorticotropic Hormone; D002945:Cisplatin