Trends in mortality from primary liver cancer in England and Wales 1975-92: influence of oral contraceptives.
Numerous case-control studies have suggested a link between the oral contraceptive pill and liver cancer. The secular trends in liver cancer mortality rates for England and Wales from 1975 to 1992 were examined to determine whether an effect of the pill was apparent. Liver cancer mortality has remained constant in women in the age groups that have had major exposure to the pill.
Mant
J W
JW
Department of Public Health and Primary Care, University of Oxford, Radcliffe Infirmary, UK.
Vessey
M P
MP
D000328:Adult; D000367:Age Factors; D000368:Aged; D006528:Carcinoma, Hepatocellular / Q000401:mortality*; D016022:Case-Control Studies; D003276:Contraceptives, Oral / Q000009:adverse effects; D004739:England / Q000453:epidemiology; D005260:Female; D006801:Humans; D008113:Liver Neoplasms / Q000139:chemically induced / Q000453:epidemiology / Q000401:mortality*; D008297:Male; D008875:Middle Aged; D009026:Mortality / Q000639:trends; D014852:Wales / Q000453:epidemiology
D003276:Contraceptives, Oral