[The value of CKMB and myoglobin determinations during reperfusion after regional myocardial ischemia in the anesthesized pig].
The efficacy of a revascularization treatment after acute coronary artery occlusion can be evaluated by different diagnoses. The ECG and the time-course of, for example, the CK isoenzyme MB are widely used as quick, objective, and almost noninvasive tools. In addition, the assessment of functional recovery of the postischemic myocardium or the evaluation of the magnitude of irreversibly injured myocardium is essential for therapeutic strategies. In the present study, myoglobin that is not yet routinely established, is compared with CKMB to answer the following questions: do measurements of serum-CKMB and serum-myoglobin reliably demonstrate 1) the success of a revascularization treatment? 2) the functional recovery of the postischemic myocardium? 3) the magnitude of irreversibly injured myocardium? To answer these questions, the left anterior descending coronary arteries of 17 anesthetized pigs were occluded for 60 min and reperfused for 180 min after successful "revascularization". The major findings of this study on anesthetized pigs are: 1) The time-course of both the CKMB activity and the myoglobin concentration exhibit the successful revascularization. 2) The CKMB maximum does not exhibit the recovery of the ventricular function, whereas the myoglobin maximum moderately correlated with the contractile state (dP/dtmax) at the end of reperfusion and significantly with the recovery of dP/dtmax during reperfusion. Recovery of the regional function (= mean thickening velocity) within the 180 min reperfusion is predicted neither by CKMB nor myoglobin analysis. 3) Both investigated markers correlate closely with the magnitude of the irreversibly injured myocardium.
Schipke
J D
JD
Institut für Experimentelle Chirurgie, Universität Düsseldorf.
Sunderdiek
U
U
Scheja
J
J
Bircks
W
W
Arnold
G
G
Kantartzis
M
M
D000818:Animals; D003402:Creatine Kinase / Q000097:blood*; D004562:Electrocardiography; D005260:Female; D006324:Heart Arrest, Induced; D006329:Heart Conduction System / Q000503:physiopathology; D006439:Hemodynamics / Q000502:physiology; D007527:Isoenzymes; D009203:Myocardial Infarction / Q000175:diagnosis* / Q000201:enzymology; D017202:Myocardial Ischemia / Q000175:diagnosis* / Q000201:enzymology; D015428:Myocardial Reperfusion Injury / Q000175:diagnosis* / Q000201:enzymology; D009204:Myocardial Revascularization; D009211:Myoglobin / Q000097:blood*; D013552:Swine; D013556:Swine, Miniature; D016277:Ventricular Function, Left / Q000502:physiology
D007527:Isoenzymes; D009211:Myoglobin; D003402:Creatine Kinase
De Wert von CKMB- und Myoglobin-Bestimmungen währen Reperfusion nach regionaler Myokardischämie am narkotisierten Schwein.