title: [The radiotherapy of heterotopic ossifications in paraplegics. The preliminary results].
abstract: OBJECTIVE
  Mobilisation of patients with paraplegia is frequently associated with acute inflammatory processes of soft tissues and muscles in the neighbourhood of joints, where subsequently heterotopic bone formation develops. Rehabilitation is then seriously compromised. For this clinical situation, no local therapeutic options exist so far except extensive resection. To evaluate if radiotherapy early in the course of the disease prevents heterotopic bone formation or if--in case of already manifest ossification and consecutive resection--recurrence can be avoided.
  
  
  METHODS
  In 20 patients with paralysis, 25 regions were irradiated with (mostly) 10 Gy in single fractions of 2 to 2.5 Gy using 8 MV photons. In 15 patients radiotherapy was performed as a primary treatment in the status of myositis; 7 patients were treated after (subtotal) resection of already manifest ossifications (2 patients were treated twice, primarily and postoperatively).
  
  
  RESULTS
  In a minimum follow-up of 12 weeks, none of the 20 irradiated patients showed any progression of the developing or already manifest ossification; thus mobilisation and rehabilitation could be carried out as desired. No side effects occurred.
  
  
  CONCLUSIONS
  The preliminary results of the present study suggest that radiotherapy is an effective local treatment with minimal side effects for the prevention of heterotopic bone formation in patients with paraplegia. Treatment should be started early in the course of the disease. Further evaluation in a prospective study seems desirable.
authors.affiliation: Klinik für Strahlentherapie, Städtisches Klinikum Karlsruhe.
authors.forename: M L
authors.initials: ML
authors.lastname: Sautter-Bihl
authors.forename: E
authors.initials: E
authors.lastname: Liebermeister
authors.forename: H G
authors.initials: HG
authors.lastname: Heinze
authors.forename: A
authors.initials: A
authors.lastname: Nanassy
authors.forename: D
authors.initials: D
authors.lastname: Stoltze
mesh_terms: D000328:Adult; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009999:Ossification, Heterotopic / Q000209:etiology / Q000532:radiotherapy*; D010264:Paraplegia / Q000150:complications* / Q000534:rehabilitation; D011182:Postoperative Care; D011879:Radiotherapy Dosage; D012008:Recurrence; D016896:Treatment Outcome
vernacular_title: Strahlentherapie heterotoper Ossifikationen bei Querschnittsgelähmten. Präliminäre Ergebnisse.