title: Zinc, copper and magnesium status in insulin-dependent diabetes.
abstract: In 20 patients with insulin-dependent diabetes mellitus the concentration of zinc in serum was 56.53 +/- 2.36 micrograms/dl (mean +/- SD). This was significantly lower (p < 0.01) than the levels measured in matched controls. In the same patients the concentrations of serum copper and magnesium were 123.46 +/- 6.59 micrograms/dl and 17.38 +/- 0.52 mg/l respectively. These copper values were higher and the magnesium levels were lower than in the control subjects (p < 0.01). These changes may be associated with the development of insulin resistance and it is proposed that patients will improve if trace elements are given as part of the therapy.
authors.affiliation: University of Cukurova Medical Faculty, Department of Biochemistry, Adana, Turkey.
authors.forename: T
authors.initials: T
authors.lastname: Isbir
authors.forename: L
authors.initials: L
authors.lastname: Tamer
authors.forename: A
authors.initials: A
authors.lastname: Taylor
authors.forename: M
authors.initials: M
authors.lastname: Isbir
mesh_terms: D000293:Adolescent; D000328:Adult; D016022:Case-Control Studies; D003300:Copper / Q000097:blood*; D003922:Diabetes Mellitus, Type 1 / Q000097:blood / Q000503:physiopathology*; D005260:Female; D006801:Humans; D007333:Insulin Resistance / Q000502:physiology; D008274:Magnesium / Q000097:blood*; D008297:Male; D015032:Zinc / Q000097:blood*
chemical_list: D003300:Copper; D008274:Magnesium; D015032:Zinc