Serum antibody production by oral immunization with dextran B512.
Serum antibodies to dextran were detected when dextran B512 was orally administered to C3H/He mice. The amounts of serum antibodies were increased along with the dose of orally administered dextran B512. For serum antibody production, differences were observed among the strains of mice. C3H/He, C57BL/6 and CBA mice produced high levels of serum antibodies to dextran, while BALB/c and DBA/2 mice produced low levels of serum antibodies. The serum antibodies had groove-type combining sites, as determined by ELISA inhibitory assay.
Tanaka
M
M
Pharmaceutical Research Laboratories, Sapporo Breweries Ltd., Yaizu, Japan.
Takeda
Y
Y
Takeo
S
S
D000284:Administration, Oral; D000818:Animals; D000917:Antibody Formation; D001666:Binding Sites, Antibody; D003911:Dextrans / Q000276:immunology*; D005260:Female; D007114:Immunization; D051379:Mice; D008815:Mice, Inbred Strains; D008970:Molecular Weight; D013045:Species Specificity
D003911:Dextrans