title: Nose drops induce vasomotion in the microcirculation of the sinus mucosa of the rabbit.
abstract: Periodic oscillations of blood in the microcirculation of the sinus mucosa in the rabbit were studied with laser-Doppler flowmetry after the application of nose drops (oxymetazoline, xylometazoline and phenylephrine) to the nasal mucosa. All of these drugs induced a dose-dependent decrease in the blood flow in the mucosa. Flowmotion was found in 9 of 21 experiments after an approximately 50% reduction in blood flow had been induced. The concentrations of the drugs which caused vasomotion corresponded to those normally administered as nose drops to man.
authors.affiliation: Department of Applied Mechanics, University of California, San Diego, La Jolla.
authors.forename: M
authors.initials: M
authors.lastname: Bende
authors.forename: K E
authors.initials: KE
authors.lastname: Arfors
authors.forename: M
authors.initials: M
authors.lastname: Intaglietta
mesh_terms: D000281:Administration, Intranasal; D000316:Adrenergic alpha-Agonists / Q000008:administration & dosage / Q000494:pharmacology*; D000818:Animals; D004305:Dose-Response Relationship, Drug; D007093:Imidazoles / Q000008:administration & dosage / Q000494:pharmacology; D017078:Laser-Doppler Flowmetry; D008297:Male; D008443:Maxillary Sinus / Q000098:blood supply* / Q000187:drug effects*; D008833:Microcirculation / Q000187:drug effects; D009092:Mucous Membrane / Q000098:blood supply / Q000187:drug effects; D014663:Nasal Decongestants / Q000008:administration & dosage / Q000494:pharmacology; D009297:Nasal Mucosa / Q000098:blood supply* / Q000187:drug effects*; D010109:Oxymetazoline / Q000008:administration & dosage / Q000494:pharmacology; D010656:Phenylephrine / Q000008:administration & dosage / Q000494:pharmacology; D011817:Rabbits
chemical_list: D000316:Adrenergic alpha-Agonists; D007093:Imidazoles; D014663:Nasal Decongestants; D010656:Phenylephrine; D010109:Oxymetazoline; C009695:xylometazoline