title: Methyl-p-hydroxyphenyllactate-esterase activity and type-II estrogen-binding sites in ovarian cancer: correlation with biological and clinico-pathological parameters.
abstract: We examined the levels of activity of methyl-p-hydroxyphenyllactate esterase (MeHPLA-ase) and cytosolic Type-II-estrogen-binding sites (Type-II EBS) in 61 and 71 cases, respectively, of primary ovarian cancer. MeHPLA-ase activity and Type-II EBS were seen to by asymmetrically distributed, in that levels were skewed towards the lower values. A statistically significant direct correlation was found between MeHPLA-ase activity and Type-II EBS. MeHPLA-ase activity and Type-II EBS were inversely correlated with ER and PR levels and showed a trend towards inverse correlation with the percentage of cells in S-phase of the cell cycle. MeHPLA-ase activity and Type-II EBS did not correlate with clinico-pathological parameters. The median MeHPLA-ase activity tended to be higher in responders than in unresponsive patients, but statistical significance was not reached. Higher Type-II-EBS levels were found in cases showing complete and partial response to chemotherapy than in cases which did not respond. A statistically significant relationship was found between high MeHPLA-ase activity and longer overall survival.
authors.affiliation: Department of Histology, Catholic University, Rome, Italy.
authors.forename: F O
authors.initials: FO
authors.lastname: Ranelletti
authors.forename: G
authors.initials: G
authors.lastname: Scambia
authors.forename: P
authors.initials: P
authors.lastname: Benedetti Panici
authors.forename: M
authors.initials: M
authors.lastname: Piantelli
authors.forename: G
authors.initials: G
authors.lastname: Ferrandina
authors.forename: G
authors.initials: G
authors.lastname: D'Agostino
authors.forename: R
authors.initials: R
authors.lastname: De Vincenzo
authors.forename: A
authors.initials: A
authors.lastname: Rinelli
authors.forename: G
authors.initials: G
authors.lastname: Isola
authors.forename: S
authors.initials: S
authors.lastname: Mancuso
mesh_terms: D002265:Carboxylic Ester Hydrolases / Q000378:metabolism*; D002352:Carrier Proteins / Q000378:metabolism*; D004261:DNA Replication; D004950:Esterases / Q000378:metabolism*; D005260:Female; D006801:Humans; D007773:Lactates / Q000378:metabolism*; D008875:Middle Aged; D010051:Ovarian Neoplasms / Q000175:diagnosis / Q000201:enzymology / Q000378:metabolism*; D011379:Prognosis; D011960:Receptors, Estrogen / Q000378:metabolism; D011980:Receptors, Progesterone / Q000378:metabolism; D016019:Survival Analysis
chemical_list: D002352:Carrier Proteins; D007773:Lactates; D011960:Receptors, Estrogen; D011980:Receptors, Progesterone; C010140:estrophilin; C055915:methyl 4-hydroxyphenyllactate; D004950:Esterases; D002265:Carboxylic Ester Hydrolases; C095492:methyl-p-hydroxyphenyllactate esterase