Effects of fluoride-supplemented sucrose on experimental dental caries and dental plaque pH.
Sucrose, 5% and 10% (w/v), supplemented with between 0 and 5 ppm fluoride (F), was tested for its influence in vitro on plaque-induced experimental in vitro enamel caries and plaque pH. Plaque growth on bovine enamel was initiated from saliva inocula and sustained in a multiple plaque growth system for up to 31 days by means of a basal medium with periodic applications of sucrose or sucrose supplemented with F. Change in enamel mineralization was assessed, before and after plaque growth, by microhardness testing and microradiography; pH was monitored with microelectrodes. It was found that enamel demineralization was inversely related to the F concentration in the range 2 to 5 ppm, for both 5% and 10% sucrose. Plaque pH responses were unaffected by the F supplements.
Cutress
T W
TW
Dental Research Unit, Health Research Council, New Zealand.
Sissons
C H
CH
Pearce
E I
EI
Wong
L
L
Anderssén
K
K
Angmar-Mansson
B
B
D000704:Analysis of Variance; D000818:Animals; D002327:Cariostatic Agents / Q000008:administration & dosage*; D002417:Cattle; D003731:Dental Caries / Q000517:prevention & control; D003743:Dental Enamel / Q000187:drug effects / Q000378:metabolism*; D003773:Dental Plaque / Q000378:metabolism*; D005459:Fluorides / Q000008:administration & dosage*; D005527:Food, Fortified; D006244:Hardness; D006801:Humans; D006863:Hydrogen-Ion Concentration; D013395:Sucrose / Q000009:adverse effects*; D017001:Tooth Demineralization / Q000139:chemically induced / Q000517:prevention & control*; D014089:Tooth Remineralization
D002327:Cariostatic Agents; D013395:Sucrose; D005459:Fluorides