Mutagenic activity of some platinum and palladium complexes.
The mutagenic properties of 16 platinum compounds were studied using Salmonella typhimurium TA98 and TA100. Eight of the compounds were considered direct mutagens, as their mutagenicity was not dependent on metabolic activation by liver extracts. Potent mutagenicity and high toxicity were exhibited by cis-Pt(NH3)2Br2, cis-Pt(NH3)2Cl2, Pt(C5H12N2)Cl2 and Pt(en)Cl2 for both bacterial strains. When distilled water was used as the carrier solvent, these compounds were strongly mutagenic and toxic, but much less so when dimethyl sulfoxide was the solvent.
Uno
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Y
Environmental Chemistry Division, National Institute for Environmental Studies, Ibaraki, Japan.
Morita
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M
D002713:Chlorine / Q000737:chemistry / Q000633:toxicity; D002945:Cisplatin / Q000633:toxicity*; D004121:Dimethyl Sulfoxide; D008110:Liver Extracts; D008862:Microsomes, Liver / Q000201:enzymology; D016296:Mutagenesis; D009152:Mutagenicity Tests; D009153:Mutagens / Q000633:toxicity*; D010984:Platinum / Q000633:toxicity*; D012486:Salmonella typhimurium / Q000187:drug effects / Q000235:genetics; D013329:Structure-Activity Relationship
D008110:Liver Extracts; D009153:Mutagens; D010984:Platinum; D002713:Chlorine; D002945:Cisplatin; D004121:Dimethyl Sulfoxide