Effects of neuromedins and related peptides on the body temperature of rats.
Neuromedin B (NMB) and neuromedin C (NMC) are peptides found in the mammalian central nervous system, and their concentrations are particularly high in the hypothalamus. The amino acid sequences of these peptides are similar to that of bombesin, which is known to induce marked hypothermia not only in amphibians but also in mammals. The effect of neuromedins and related peptides on the body temperature regulation was examined in the rat under a thermoneutral environment. The findings indicated that NMC caused moderate hypothermia following intracerebroventricular administration, while the effect of NMB was meager, suggesting that these two neuropeptides possess different physiological functions in the brain.
Itoh
S
S
Department of Physiology, Kyoto Prefectural University of Medicine, Japan.
Takashima
A
A
Itoh
T
T
Morimoto
T
T
D000595:Amino Acid Sequence; D000818:Animals; D001831:Body Temperature / Q000187:drug effects*; D001839:Bombesin / Q000494:pharmacology*; D001921:Brain / Q000502:physiology; D007276:Injections, Intraventricular; D008297:Male; D008969:Molecular Sequence Data; D015287:Neurokinin B / Q000031:analogs & derivatives* / Q000494:pharmacology; D009842:Oligopeptides / Q000494:pharmacology; D010446:Peptide Fragments / Q000235:genetics / Q000494:pharmacology*; D011761:Pyrrolidonecarboxylic Acid / Q000031:analogs & derivatives; D051381:Rats; D017208:Rats, Wistar
D009842:Oligopeptides; D010446:Peptide Fragments; C003291:ranatensin; C010212:litorin; C040794:neuromedin C; D015287:Neurokinin B; C038393:neuromedin B; D001839:Bombesin; D011761:Pyrrolidonecarboxylic Acid