title: [The effect of hemodilution and autotransfusion on diagnostic levels of digoxin in serum of patients operated on with extracorporeal circulation].
abstract: In many patients operated on for valvular heart diseases indications are present to digitalis administration in the preoperative period. During extracorporeal circulation fluctuations occur of blood potassium concentration which increase the risk for toxic effect of digitalis. In the work, digoxin concentration was studied in the serum of patients operated on in extracorporeal circulation in whom administration of this drug was discontinued 48 hours before the operation. The first digoxin dose (0.5 mg) was given directly after withdrawal of extracorporeal circulation, and another 0.5 mg was given after 4 hours. Digoxin concentrations were determined by fluorescence-polarization-immunological method using TD* Abbott device. The digoxin concentration increased rapidly and reached its peak after 6 hours (1.9 ng/ml), decreasing after 12 hours to 0.9 ng/ml and persisted at this therapeutic level in further samples. The present studies demonstrated that digoxin administration directly after withdrawal of extracorporeal circulation and within 24 hours after the operation in commonly accepted doses provided therapeutic concentration of the drug and caused no increase of the risk for toxic reaction development.
authors.affiliation: Kliniki Kardio-Torakochirurgii, Poznaniu.
authors.forename: W
authors.initials: W
authors.lastname: Sarnowski
authors.forename: A
authors.initials: A
authors.lastname: Ponizyński
authors.forename: Z
authors.initials: Z
authors.lastname: Lowicki
authors.forename: W
authors.initials: W
authors.lastname: Dyszkiewicz
authors.forename: L
authors.initials: L
authors.lastname: Paluszkiewicz
mesh_terms: D000328:Adult; D001022:Aortic Valve Insufficiency / Q000601:surgery; D001804:Blood Transfusion, Autologous; D004077:Digoxin / Q000097:blood* / Q000627:therapeutic use; D005112:Extracorporeal Circulation / Q000379:methods*; D005260:Female; D006438:Hemodilution; D006801:Humans; D008297:Male; D008875:Middle Aged; D008944:Mitral Valve Insufficiency / Q000601:surgery
chemical_list: D004077:Digoxin
vernacular_title: Wpływ hemodylucji i autotransfuzji na stezenie digoksyny w surowicy chorych operowanych w krazeniu pozaustrojowym.