Sequence and expression of Sox-18 encoding a new HMG-box transcription factor.
The newly identified Sox gene family (Sry-like HMG-box gene) is characterized by a conserved DNA sequence encoding a domain of approx. 80 amino acids (aa) which is responsible for sequence-specific DNA binding. The first member isolated, the mammalian Y-linked testis-determining gene, Sry, is necessary and sufficient for male development. We report here the identification of two new members of this family, Sox-17 and 18. We have determined the full cDNA sequence of Sox-18 which encodes a protein of 378 aa. Sox-18 mRNA transcripts were restricted to heart, lung and skeletal muscle in the adult mouse.
Dunn
T L
TL
Centre for Molecular and Cellular Biology, University of Queensland, St. Lucia, Brisbane, Australia.
Mynett-Johnson
L
L
Wright
E M
EM
Hosking
B M
BM
Koopman
P A
PA
Muscat
G E
GE
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D003001:Cloning, Molecular; D016384:Consensus Sequence; D018076:DNA, Complementary / Q000235:genetics; D006609:High Mobility Group Proteins / Q000235:genetics*; D008297:Male; D051379:Mice; D008969:Molecular Sequence Data; D055760:SOXF Transcription Factors; D017386:Sequence Homology, Amino Acid; D012733:Sex Differentiation / Q000235:genetics; D014157:Transcription Factors / Q000235:genetics*
D018076:DNA, Complementary; D006609:High Mobility Group Proteins; D055760:SOXF Transcription Factors; C490653:Sox18 protein, mouse; D014157:Transcription Factors