title: Localized prostate cancer. Relationship of tumor volume to clinical significance for treatment of prostate cancer.
abstract: BACKGROUND
  Using the Surveillance, Epidemiology, and End Results Program of the National Cancer Institute and American total mortality rates, the authors calculated the probability at birth of having a diagnosis of prostate cancer within a man's life to be 8.8% and then subtracted the incidence of microscopic Stage A cancers too small to ever be clinically significant. This gave a final probability of 8%.
  
  
  METHODS
  Prostates were examined after 139 consecutive unselected cystoprostatectomies from patients with bladder cancers in whom it was unknown whether they had prostate cancer. Prostate cancer was found in 55 patients (40%); the volume of the largest cancer in each specimen was determined using histologic morphometry. The authors identified the 8% of these 139 cytoprostatectomy specimens with the largest volume of prostate cancer.
  
  
  RESULTS
  The largest 11 of the 55 cancers represented 7.9% of the total 139 samples. These cancers ranged in volume from 0.5-6.1 ml, representing only 20% of all patients with prostate cancer.
  
  
  CONCLUSIONS
  If the strong evidence is accepted that cancer progression is proportional to cancer volume, it was concluded that prostate cancers larger than 0.5 ml appear to correspond to the 8% of men who will be diagnosed with a clinically significant carcinoma, as derived previously. Conversely, those 80% of prostate cancers smaller than 0.5 ml probably are not likely to reach a clinically significant size in view of the long doubling time of this cancer.
authors.affiliation: Department of Urology, Stanford University School of Medicine, CA 94305-5118.
authors.forename: T A
authors.initials: TA
authors.lastname: Stamey
authors.forename: F S
authors.initials: FS
authors.lastname: Freiha
authors.forename: J E
authors.initials: JE
authors.lastname: McNeal
authors.forename: E A
authors.initials: EA
authors.lastname: Redwine
authors.forename: A S
authors.initials: AS
authors.lastname: Whittemore
authors.forename: H P
authors.initials: HP
authors.lastname: Schmid
mesh_terms: D000328:Adult; D000367:Age Factors; D000368:Aged; D000369:Aged, 80 and over; D006801:Humans; D015994:Incidence; D008297:Male; D008875:Middle Aged; D009367:Neoplasm Staging; D011336:Probability; D017430:Prostate-Specific Antigen / Q000097:blood; D011471:Prostatic Neoplasms / Q000097:blood / Q000453:epidemiology / Q000473:pathology*; D014481:United States / Q000453:epidemiology
chemical_list: D017430:Prostate-Specific Antigen