Inhibition of adriamycin-induced micronuclei by desferrioxamine in Swiss albino mice.
Swiss albino male mice, 6-8 weeks old, were treated i.p. with different doses of desferrioxamine dissolved in water for 7 days. Some of the mice in each group were injected i.p. with adriamycin (15 mg/kg) and killed after 30 or 24, 48 and 72 h. The femoral cells of mice in different groups were collected and studied. Desferrioxamine treatment failed to affect the incidence of micronuclei at doses of 125-250 mg/kg/day. Pretreatment with desferrioxamine was found to provide significant protection against adriamycin-induced micronuclei without interfering with its cytotoxic potential.
al-Shabanah
O A
OA
Department of Pharmacology, College of Pharmacy, King Saud University, Riyadh, Saudi Arabia.
D000818:Animals; D016587:Antimutagenic Agents / Q000494:pharmacology*; D004249:DNA Damage; D003676:Deferoxamine / Q000494:pharmacology*; D004317:Doxorubicin / Q000633:toxicity*; D004912:Erythrocytes / Q000187:drug effects; D008297:Male; D051379:Mice; D048629:Micronuclei, Chromosome-Defective / Q000187:drug effects; D015162:Micronucleus Tests
D016587:Antimutagenic Agents; D004317:Doxorubicin; D003676:Deferoxamine