title: Provocation of porphyria cutanea tarda by KUVA-therapy of vitiligo.
abstract: Therapy with khellin and UVA irradiation (KUVA) is a therapeutic approach to vitiligo. Little is known about the photobiological properties of khellin and its long-term side-effects after prolonged administration. A 47-year-old woman suffering from acral vitiligo since the age of 3 is reported, who developed blisters on hands and fingers during KUVA-therapy. Laboratory findings were consistent with hereditary porphyria cutanea tarda. Electron microscopic examination of a blister revealed clefting below the basement membrane. It is proposed that khellin in some way provoked the porphyria cutanea tarda in this patient.
authors.affiliation: Department of Dermatology, Ludwig-Maximilians-University, Munich, Germany.
authors.forename: T
authors.initials: T
authors.lastname: Jansen
authors.forename: M
authors.initials: M
authors.lastname: Megahed
authors.forename: E
authors.initials: E
authors.lastname: Hölzle
authors.forename: G
authors.initials: G
authors.lastname: Plewig
mesh_terms: D001485:Basement Membrane / Q000187:drug effects / Q000473:pathology; D001768:Blister / Q000139:chemically induced / Q000473:pathology; D005260:Female; D006229:Hand Dermatoses / Q000188:drug therapy*; D006801:Humans; D007666:Khellin / Q000009:adverse effects*; D008875:Middle Aged; D010778:Photochemotherapy / Q000009:adverse effects*; D017119:Porphyria Cutanea Tarda / Q000139:chemically induced* / Q000235:genetics / Q000473:pathology; D014820:Vitiligo / Q000188:drug therapy*
chemical_list: D007666:Khellin