Bullous pemphigoid successfully controlled by tetracycline and nicotinamide.
In 1986, Berk and Lorincz reported the efficacy of tetracycline and nicotinamide in the treatment of bullous pemphigoid (BP). In the present study of seven patients with BP, we found that a regimen of 2 g tetracycline combined with 2 g nicotinamide daily was effective in clearing the skin lesions. Total remission was achieved within 6-8 weeks, after which the dose was gradually tapered. The mean duration of therapy was 7 months. No effect on the titre of antibasement membrane antibodies was observed. The mode of action of this therapy is unknown.
Kolbach
D N
DN
Department of Dermatology, Academisch Ziekenhuis, Groningen, Velsen, The Netherlands.
Remme
J J
JJ
Bos
W H
WH
Jonkman
M F
MF
De Jong
M C
MC
Pas
H H
HH
van der Meer
J B
JB
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000900:Anti-Bacterial Agents / Q000627:therapeutic use*; D004338:Drug Combinations; D005260:Female; D005500:Follow-Up Studies; D006801:Humans; D008297:Male; D008875:Middle Aged; D009536:Niacinamide / Q000627:therapeutic use*; D010391:Pemphigoid, Bullous / Q000188:drug therapy*; D013752:Tetracycline / Q000627:therapeutic use*; D016896:Treatment Outcome
D000900:Anti-Bacterial Agents; D004338:Drug Combinations; D009536:Niacinamide; D013752:Tetracycline