[Diversity of signal transduction pathways which induce apoptosis of thymocytes. Role of bcl-2, pim-1, c-myc and p53 genes in selection processes of thymocytes].
There are independent signaling pathways which transmit apoptotic signals in thymocytes. c-Myc and p53 proteins participate in the apoptosis induction, whereas Bcl-2 and Pim-1 proteins inhibit complex apoptotic machinery.
Matuszyk
J
J
Laboratorium Immunologii Komórkowej Instytutu Immunologii i Terapii Doświadczalnej PAN we Wrocławiu.
Strzadała
L
L
D000818:Animals; D017209:Apoptosis / Q000235:genetics*; D002478:Cells, Cultured; D005786:Gene Expression Regulation / Q000502:physiology; D016259:Genes, myc / Q000502:physiology; D016158:Genes, p53 / Q000502:physiology; D006801:Humans; D011518:Proto-Oncogene Proteins / Q000235:genetics*; D015398:Signal Transduction / Q000235:genetics*; D013950:Thymus Gland / Q000166:cytology / Q000276:immunology*
D011518:Proto-Oncogene Proteins
Róznorodność szlaków przekazywania sygnału do apoptozy tymocytów. Rola genów bcl-2, pim-1, c-myc i p53 w procesach selekcji tymocytów.