Participation of monocytes and macrophages in canine glomerular disease.
The presence of monocytes/macrophages (MPs) in renal glomeruli was investigated in 86 dogs with different types of glomerulopathies. The identification of MPs in tissue sections was based on cytological criteria and the immunohistochemical demonstration of lysozyme. The highest numbers of MPs in glomeruli were observed in focal and diffuse mesangial proliferative glomerulonephritis (MesPGN), diffuse endocapillary proliferative glomerulonephritis (DEPGN), and diffuse mesangiocapillary glomerulonephritis (DMCGN). In cases of minor glomerular abnormalities (MGA), focal and segmental hyalinosis and sclerosis (FGS), diffuse membranous glomerulonephritis (DMemGN), and diffuse sclerosing glomerulonephritis (DSGN) the presence of glomerular MPs was low. Particularly in MesPGN, the number of MPs was correlated with glomerular hypercellularity and, additionally in DMCGN, with the degree of proteinuria. The results of this study suggest that MPs may be involved in functional and morphological alterations in different types of canine glomerulopathies.
Vilafranca
M
M
Department of Animal Pathology, Faculty of Veterinary Medicine, Autonomous University of Barcelona, Spain.
Ferrer
L
L
Wohlsein
P
P
Trautwein
G
G
D000818:Animals; D002452:Cell Count / Q000662:veterinary; D004283:Dog Diseases / Q000473:pathology*; D004285:Dogs; D005260:Female; D007150:Immunohistochemistry; D007674:Kidney Diseases / Q000473:pathology / Q000662:veterinary*; D007678:Kidney Glomerulus / Q000473:pathology*; D008264:Macrophages / Q000473:pathology*; D008297:Male; D009000:Monocytes / Q000473:pathology*; D009113:Muramidase / Q000032:analysis
D009113:Muramidase