[Immuno histochemical study of endothelin-1 in breast cancer].
Endothelin-1 (ET-1) content was measured in tissue sections from 42 human breast cancer from grade 1 to grade III and from 8 normal breast tissue by immunohistochemistry and image analysis methods. The ET-1 was stained as brownish grains localized in the cytoplasm of tumor cells and normal breast epithelial cells. However, both the proportion of ET-1 positive cells and ET-1 cellular content were significantly higher in cancer cells than in normal breast epithelium. Moreover, the ET-1 content in the tumor cells was inversely correlated with the degree of tumor cell differentiation. It is suggested that ET-1 is synthesized by human breast cancer and its over expression may induce an abnormal proliferation of breast tissue and result in malignant growth.
Lu
J
J
Department of Pathology, 304th Hospital of PLA, Beijing.
Liang
Y
Y
Wang
X
X
D000328:Adult; D001943:Breast Neoplasms / Q000737:chemistry* / Q000473:pathology; D002471:Cell Transformation, Neoplastic; D016232:Endothelins / Q000378:metabolism*; D004848:Epithelium / Q000737:chemistry; D005260:Female; D006801:Humans; D007091:Image Processing, Computer-Assisted; D007150:Immunohistochemistry; D008875:Middle Aged
D016232:Endothelins