title: Slipped capital femoral epiphysis during treatment with recombinant human growth hormone for Turner syndrome.
abstract: Recombinant human growth hormone has recently been used to treat the short stature of Turner syndrome. However, this therapy may induce slipped capital femoral epiphysis, since the epiphyseal plate widens and becomes weak through either growth hormone or hypogonadism. This report shows that a slipped capital femoral epiphysis occurred during this treatment for an 11-year-old girl who was suffering from Turner syndrome. Thus, these patients who are being treated with growth hormone should be carefully observed.
authors.affiliation: Department of Orthopaedic Surgery, Nagoya University School of Medicine, Japan.
authors.forename: S
authors.initials: S
authors.lastname: Sakano
authors.forename: Y
authors.initials: Y
authors.lastname: Yoshihashi
authors.forename: T
authors.initials: T
authors.lastname: Miura
mesh_terms: D002648:Child; D004839:Epiphyses, Slipped / Q000139:chemically induced / Q000150:complications / Q000209:etiology*; D005260:Female; D005270:Femur Head; D013006:Growth Hormone / Q000009:adverse effects / Q000627:therapeutic use*; D006801:Humans; D011994:Recombinant Proteins / Q000009:adverse effects / Q000627:therapeutic use; D014424:Turner Syndrome / Q000150:complications / Q000188:drug therapy*
chemical_list: D011994:Recombinant Proteins; D013006:Growth Hormone