[Effects of dietary fat on permeability of the protective intestinal barrier to macromolecules in experimental anaphylaxis].
Wistar rats were sensitized with hen egg ovalbumin (OVA) intraperitoneally and were fed with diets that contained 12% fish oil (FO) or sunflower oil for 3 weeks with a purpose to study the influence of dietary fat source on the macromolecular permeability of small intestine in systemic anaphylaxis. 29 days later the systemic anaphylaxis was challenged by i.v. administration of OVA. This reaction was aggravated in animals fed with FO this being supported by morphofunctional changes pattern in small intestine. The deleterious effect on intestinal protective barrier efficiency against polyethyleneglycol 4000 macromolecules was noticed in rats fed with FO containing large amounts of n-3 PUFA. It's suggested that the prevention of deleterious effect of FO is possible by increase of dietary antioxidative factors consumption that might be taken into consideration during some kinds of dietary treatment.
Gmoshinskiĭ
I V
IV
Ermekpaeva
R A
RA
Lysikov
Iu A
IuA
Kulakova
S N
SN
Mazo
V K
VK
Morozov
I A
IA
D000707:Anaphylaxis / Q000378:metabolism* / Q000473:pathology; D000818:Animals; D000975:Antioxidants / Q000494:pharmacology; D004041:Dietary Fats / Q000494:pharmacology*; D005395:Fish Oils / Q000494:pharmacology; D007413:Intestinal Mucosa / Q000378:metabolism* / Q000473:pathology; D007422:Intestines / Q000187:drug effects / Q000473:pathology; D046911:Macromolecular Substances; D008297:Male; D010539:Permeability; D051381:Rats; D017208:Rats, Wistar
D000975:Antioxidants; D004041:Dietary Fats; D005395:Fish Oils; D046911:Macromolecular Substances
Vliianie zhirovogo komponenta ratsiona na pronitsaemost' dlia makromolekul zashchitnogo bar'era kishki pri éksperimental'noĭ anafilaksii.