Upregulated expression of peripheral serotonergic receptors in migraine and cluster headache by sumatriptan.
The double-label flow cytometric analysis of peripheral serotonergic pathways of migraine and cluster headache on a monocyte model has been used to evaluate the activity of drugs with a selective activity on central vascular 5-HT1D receptors, such as sumatriptan, ergotamine and ondansetron. The results indicated that sumatriptan and ergotamine progressively increase the peripheral expression of 5-HT (5-hydroxytryptamine, serotonin). The increase obtained in migraine after ergotamine is more evident than that obtained in cases of cluster headache. Ondansetron produced a moderate increase in serotonergic expression only in cluster headache. The events that occur at intracranic neural and vascular level may cause the described changes of 5-HT expression on the monocyte model as an indirect, reflective, peripheral registration of central serotonergic variations during headache attack as well as during the drug-sustained recovery phase.
Martelletti
P
P
Department of Clinical Medicine, Headache Centre, University La Sapienza, Rome, Italy.
Stirparo
G
G
Rinaldi
C
C
Giacovazzo
M
M
D000328:Adult; D000704:Analysis of Variance; D001667:Binding, Competitive; D003027:Cluster Headache / Q000188:drug therapy / Q000378:metabolism*; D004878:Ergotamine / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D005260:Female; D005434:Flow Cytometry; D006801:Humans; D008297:Male; D008881:Migraine Disorders / Q000188:drug therapy / Q000378:metabolism*; D009000:Monocytes / Q000166:cytology / Q000187:drug effects / Q000378:metabolism*; D017294:Ondansetron / Q000378:metabolism / Q000494:pharmacology / Q000627:therapeutic use; D011985:Receptors, Serotonin / Q000096:biosynthesis / Q000187:drug effects* / Q000378:metabolism; D018170:Sumatriptan / Q000378:metabolism / Q000494:pharmacology* / Q000627:therapeutic use; D015854:Up-Regulation
D011985:Receptors, Serotonin; D017294:Ondansetron; D018170:Sumatriptan; D004878:Ergotamine