[A case of remission of recurrent carcinosarcoma of the uterus with massive ascites by carboplatin].
A case of remission of recurrent carcinosarcoma of the uterus with massive ascites by chemotherapy using carboplatin (CBDCA) is reported. A 75-year-old female was diagnosed with cancer of the uterine body. She underwent abdominal total hysterectomy with bilateral salpingo-oophorectomy, which revealed carcinosarcoma of the uterus penetrating the myometrium and reaching the serosa of the uterus. Eight weeks after, she developed abdominal distension, obstruction of bilateral ureters and bleeding tumor measuring 5 cm in diameter at the vaginal cuff ending. Acute retention of bloody ascites of more than 2500 ml was demonstrated. Abdominal centesis, aspiration of ascites and intraperitoneal administration of 600 mg of CBDCA were performed. Two weeks after single use of CBDCA, the ascites completely disappeared and there was recovery from anuria. The remission has lasted more than 4 months, which has suggested the efficacy of CBDCA for uterine carcinosarcoma.
Takada
S
S
Dept. of Obstetrics and Gynecology, Teikyo University Hospital.
Tamura
A
A
Hiraoka
K
K
Ogino
M
M
Mori
H
H
Imamura
T
T
D000368:Aged; D001202:Ascitic Fluid / Q000188:drug therapy*; D016190:Carboplatin / Q000627:therapeutic use*; D002296:Carcinosarcoma / Q000150:complications / Q000188:drug therapy*; D005260:Female; D006801:Humans; D012074:Remission Induction; D014517:Ureteral Obstruction / Q000209:etiology; D014594:Uterine Neoplasms / Q000150:complications / Q000188:drug therapy*
D016190:Carboplatin