Primary non-clear-cell adenocarcinomas of the vagina in older DES-exposed women.
The association between in utero diethylstilbestrol (DES) exposure and the development of clear-cell adenocarcinoma of the vagina and cervix has been well described. However, non-clear-cell mucin-secreting adenocarcinoma in women with DES exposure has not been previously reported. We present two cases of non-clear-cell mucinous adenocarcinoma in women having a history of in utero DES exposure. These cancers were found in older women and were more advanced than the clear-cell adenocarcinoma associated with DES. Histologic features of these tumors were notable for atypical, irregular glands lined by endocervical, intestinal, and endometrioid epithelium. The development of non-clear-cell adenocarcinoma of the vagina in these patients may be associated with DES exposure in utero. Long-term surveillance of DES-exposed women may be warranted.
DeMars
L R
LR
Department of Obstetrics and Gynecology, University of North Carolina, Chapel Hill 27599-7570, USA.
Van Le
L
L
Huang
I
I
Fowler
W C
WC
D002288:Adenocarcinoma, Mucinous / Q000139:chemically induced* / Q000473:pathology; D000328:Adult; D004054:Diethylstilbestrol / Q000009:adverse effects*; D005260:Female; D006801:Humans; D011247:Pregnancy; D011297:Prenatal Exposure Delayed Effects; D014625:Vaginal Neoplasms / Q000139:chemically induced* / Q000473:pathology
D004054:Diethylstilbestrol