title: Factitious pheochromocytoma: novel mimickry by Valsalva maneuver and clues to diagnosis.
abstract: Factitious pheochromocytoma usually occurs in patients surreptitiously ingesting adrenergic medications. We encountered a case of factitious pheochromocytoma where in the subject mimicked hemodynamic (profound hypertension) and biochemical (plasma catecholamine elevation) manifestations of the illness by consciously altering autonomic function with Valsalva maneuver. Clues to this presentation included visible performance of Valsalva maneuver, marked disparity between blood pressures recorded in the presence and absence of the subject's knowledge, normal urinary catecholamine and metabolite excretion, and normal plasma chromogranin A. We reproduced, in part, the hemodynamic and biochemical manifestations of this presentation with Valsalva maneuver in healthy subjects.
authors.affiliation: Department of Medicine, University of California, San Diego 92161, USA.
authors.forename: M T
authors.initials: MT
authors.lastname: Kailasam
authors.forename: R J
authors.initials: RJ
authors.lastname: Parmer
authors.forename: R A
authors.initials: RA
authors.lastname: Stone
authors.forename: S
authors.initials: S
authors.lastname: Shankel
authors.forename: B P
authors.initials: BP
authors.lastname: Kennedy
authors.forename: M G
authors.initials: MG
authors.lastname: Ziegler
authors.forename: D T
authors.initials: DT
authors.lastname: O'Connor
mesh_terms: D000310:Adrenal Gland Neoplasms / Q000175:diagnosis* / Q000503:physiopathology; D000328:Adult; D001794:Blood Pressure / Q000502:physiology; D002395:Catecholamines / Q000097:blood; D053379:Chromogranin A; D002864:Chromogranins / Q000097:blood; D003937:Diagnosis, Differential; D005162:Factitious Disorders / Q000175:diagnosis* / Q000503:physiopathology; D005260:Female; D006801:Humans; D008297:Male; D010673:Pheochromocytoma / Q000175:diagnosis* / Q000503:physiopathology; D019966:Substance-Related Disorders / Q000175:diagnosis; D014636:Valsalva Maneuver
chemical_list: D002395:Catecholamines; D053379:Chromogranin A; D002864:Chromogranins