title: Chronic intrahepatic cholestasis in sickle cell disease requiring exchange transfusion.
abstract: A 15 year old boy with sickle cell disease developed intrahepatic cholestasis. A course of exchange transfusion successfully corrected the extreme hyperbilirubinaemia over one year. Upon stopping the exchange transfusion programme the hyperbilirubinaemia relapsed but transfusion was effective when reinstituted.
authors.affiliation: Department of Haematology, Royal Postgraduate Medical School, London.
authors.forename: A
authors.initials: A
authors.lastname: O'Callaghan
authors.forename: S G
authors.initials: SG
authors.lastname: O'Brien
authors.forename: M
authors.initials: M
authors.lastname: Ninkovic
authors.forename: G P
authors.initials: GP
authors.lastname: Butcher
authors.forename: C S
authors.initials: CS
authors.lastname: Foster
authors.forename: J R
authors.initials: JR
authors.lastname: Walters
authors.forename: I A
authors.initials: IA
authors.lastname: Roberts
mesh_terms: D000293:Adolescent; D000755:Anemia, Sickle Cell / Q000150:complications*; D002780:Cholestasis, Intrahepatic / Q000628:therapy*; D002908:Chronic Disease; D005078:Exchange Transfusion, Whole Blood; D006801:Humans; D006932:Hyperbilirubinemia / Q000628:therapy; D008297:Male; D012008:Recurrence