title: Bone marrow purging with dibutyl phthalate--experimental basis and a preliminary clinical application.
abstract: It has been found recently that di-n-butyl phthalate (DBP) possesses a new pharmacological activity in the selective elimination of tumor cells from marrow. In combination with long-term liquid culture of marrow cells in vitro, DBP purged autologous bone marrow transplantation has first been applied to a case of acute myeloid leukemia at the first complete remission with successful reconstitution of hematopoiesis.
authors.affiliation: Department of Experimental Hematology, Beijing Institute of Radiation Medicine, People's Republic of China.
authors.forename: C
authors.initials: C
authors.lastname: Wu
authors.forename: K
authors.initials: K
authors.lastname: Yang
authors.forename: X
authors.initials: X
authors.lastname: Pei
authors.forename: A
authors.initials: A
authors.lastname: Tang
authors.forename: F
authors.initials: F
authors.lastname: Wang
authors.forename: L
authors.initials: L
authors.lastname: Wang
mesh_terms: D000328:Adult; D001854:Bone Marrow Cells; D016465:Bone Marrow Purging / Q000379:methods*; D016026:Bone Marrow Transplantation / Q000379:methods; D003993:Dibutyl Phthalate / Q000494:pharmacology*; D006410:Hematopoiesis / Q000187:drug effects*; D006801:Humans; D015470:Leukemia, Myeloid, Acute / Q000628:therapy; D014182:Transplantation, Autologous
chemical_list: D003993:Dibutyl Phthalate