Changes in monkey plasma purines induced by repeated doses of CI-1000, a novel inhibitor of purine nucleoside phosphorylase.
Robertson
D G
DG
Department of Pathology and Experimental Toxicology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Co., Ann Arbor, MI, USA.
Urda
E R
ER
Bleavins
M R
MR
Lalwani
N D
ND
D000284:Administration, Oral; D000818:Animals; D004305:Dose-Response Relationship, Drug; D004334:Drug Administration Schedule; D006147:Guanine / Q000008:administration & dosage / Q000031:analogs & derivatives* / Q000494:pharmacology; D006151:Guanosine / Q000097:blood; D019271:Hypoxanthine; D007042:Hypoxanthines / Q000097:blood; D007288:Inosine / Q000097:blood; D007700:Kinetics; D008252:Macaca fascicularis; D011683:Purine-Nucleoside Phosphorylase / Q000037:antagonists & inhibitors*; D011687:Purines / Q000097:blood*; D013997:Time Factors
D007042:Hypoxanthines; D011687:Purines; D006151:Guanosine; C076778:9-deaza-9-(3-thienylmethyl)guanine; D019271:Hypoxanthine; D007288:Inosine; D006147:Guanine; D011683:Purine-Nucleoside Phosphorylase