Frontal lobe phosphorus metabolism and neuropsychological function in aging and in Alzheimer's disease.
31P Magnetic resonance spectroscopy of the frontal lobe was performed in 17 patients with Alzheimer's disease (AD), 8 elderly controls (EC), and 17 young controls (YC). The phosphocreatine/inorganic phosphate (PCr/Pi) ratio in AD (2.32 +/- 0.26 SD) was significantly lower than in EC (2.65 +/- 0.41). In AD patients, a correlation was observed between the PCr/Pi ratio and the dementia rating scale (r = -0.50, p = 0.04). A significant positive correlation between PCr/Pi ratio and age was observed in both AD (r = 0.67, p = 0.003) and YC (r = 0.63, p = 0.006) groups, however, suggesting caution in interpretation of this ratio in AD. We did not find differences between AD, EC, or YC in any other spectroscopic measure. A significant sex difference in the phosphomonoester/phosphodiester ratio (PME/PDE) ratio was observed in AD brain. Females had a lower PME/PDE ratio than males.
Smith
C D
CD
Magnetic Resonanance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington 40536, USA.
Pettigrew
L C
LC
Avison
M J
MJ
Kirsch
J E
JE
Tinkhtman
A J
AJ
Schmitt
F A
FA
Wermeling
D P
DP
Wekstein
D R
DR
Markesberry
W R
WR
D000328:Adult; D000368:Aged; D000375:Aging; D000544:Alzheimer Disease / Q000378:metabolism* / Q000503:physiopathology / Q000523:psychology*; D005260:Female; D005625:Frontal Lobe / Q000378:metabolism*; D006801:Humans; D008297:Male; D008875:Middle Aged; D009483:Neuropsychological Tests; D010725:Phosphocreatine / Q000378:metabolism; D010758:Phosphorus / Q000378:metabolism*
D010725:Phosphocreatine; D010758:Phosphorus