Impact of MHC class I gene on resistance to murine AIDS.
Development of murine AIDS in mice following infection with LP-BM5 murine leukaemia virus (MuLV) is highly strain dependent, with strain differences determined by genes within and outside H-2. Among H-2 genes, the Dd gene is the most closely associated with resistance to LP-BM5 MuLV infection. However, the Dd-mediated resistance is highly influenced by outside H-2 genes, i.e. A lineage strains are more resistant than mice strains of B6/B10 lineage. In this study, the mice having BALB background were analysed and, similarly to A lineage mice, only Dd gene products were found to be required to provide resistance to LP-BM5 MuLV infection. Furthermore, BALB/c Kh mice bearing both Dd and Ld genes clearly showed obviously higher resistance than BALB/c-H-2dm2 mice solely having the Dd gene. In addition, in the long-term observation of the effect of the Dd gene on B6/B10 background mice, D8 mice having the Dd gene as a transgene and expressing a high level Dd gene product showed higher resistance than naturally recombinant B10.A(18R) mice. These results suggest that the MAIDS resistance associated with the D end loci is dependent on the level of expression of an MHC class I gene.
Makino
M
M
Laboratory of Immunopathology, National Institute of Allergy and Infectious Disease, National Institute of Health, Bethesda, MD, USA.
Murphy
D B
DB
Melvold
R W
RW
Hartley
J W
JW
Morse
H C
HC
D000818:Animals; D005805:Genes, MHC Class I; D007113:Immunity, Innate; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D016183:Murine Acquired Immunodeficiency Syndrome / Q000235:genetics / Q000276:immunology*