title: Single- and multiple-dose-response relationships of beta-carotene in cystic fibrosis.
abstract: Concentrations of carotenoids are low in patients with cystic fibrosis (CF) and are associated with essential fatty acid deficiency and increased markers of inflammation. We conducted single- and multiple-dose studies of beta-carotene supplementation in patients with CF. Dose-proportional increases in beta-carotene concentrations were found, although clearance was independent of dose. Large doses of beta-carotene were necessary to achieve normal plasma levels.
authors.affiliation: Department of Pediatrics, Michigan State University, Kalamazoo Center for Medical Studies 49008, USA.
authors.forename: D N
authors.initials: DN
authors.lastname: Homnick
authors.forename: C R
authors.initials: CR
authors.lastname: Spillers
authors.forename: S R
authors.initials: SR
authors.lastname: Cox
authors.forename: J H
authors.initials: JH
authors.lastname: Cox
authors.forename: L A
authors.initials: LA
authors.lastname: Yelton
authors.forename: M J
authors.initials: MJ
authors.lastname: DeLoof
authors.forename: L K
authors.initials: LK
authors.lastname: Oliver
authors.forename: T V
authors.initials: TV
authors.lastname: Ringer
mesh_terms: D000276:Adjuvants, Immunologic / Q000008:administration & dosage* / Q000493:pharmacokinetics; D000284:Administration, Oral; D000328:Adult; D002338:Carotenoids / Q000008:administration & dosage* / Q000493:pharmacokinetics; D002648:Child; D003550:Cystic Fibrosis / Q000097:blood / Q000188:drug therapy*; D004305:Dose-Response Relationship, Drug; D005260:Female; D006801:Humans; D008297:Male; D012044:Regression Analysis; D013997:Time Factors; D019207:beta Carotene
chemical_list: D000276:Adjuvants, Immunologic; D019207:beta Carotene; D002338:Carotenoids