title: The role of material surface chemistry in implant device calcification: a hypothesis.
abstract: We proposed that a similar mechanism for calcification exists for poly(ether)urethanes and glutaraldehyde stabilized tissue. The mechanism is based on the propensity of the polyether component of the materials to complex calcium and provide initiating sites for ultimate formation of calcific deposits. Data evaluating the role ether containing materials have on calcification demonstrate that the rate of mineralization of either tissue valves or polymer valves can be controlled by paying attention to the basic chemical mechanism of complexation occurring at the surface and within the bulk of the implant devices. The molecular models described above, point out that the driving force for complexation with either the polyethers of the polyurethane or the polyether of glutaraldehyde is very strong, therefore, controlling the driving force may lead to medical devices with longer term durability.
authors.affiliation: CarboMedics, Inc., Austin, Texas 78752, USA.
authors.forename: R J
authors.initials: RJ
authors.lastname: Thoma
authors.forename: R E
authors.initials: RE
authors.lastname: Phillips
mesh_terms: D000818:Animals; D001705:Bioprosthesis; D002114:Calcinosis; D055598:Chemical Phenomena; D002621:Chemistry; D006350:Heart Valve Prosthesis; D006801:Humans; D011140:Polyurethanes; D019736:Prostheses and Implants
chemical_list: D011140:Polyurethanes