Phosphorylation of nuclear proteins in a chronic, uncontrollable stress model.
The changes in the phosphorylation of nuclear proteins isolated from cell nuclei of hypothalamus, cerebral cortex, and hippocampus of rats subjected for varying times to a chronic uncontrollable stress model were investigated. A brief duration (24 h) induced a substantial increase of the phosphorylation of nuclear proteins isolated from hypothalamus (270%), from the cerebral cortex (ca. 230%), and from the hippocampus (ca. 160%). More extended durations (96 and 168 h) were accompanied by a statistically significant decrease in the degree of phosphorylation of proteins.
Velichkova
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AA
Brain Research Institute, Bulgarian Academy of Sciences.
D000818:Animals; D001923:Brain Chemistry / Q000187:drug effects / Q000502:physiology; D002540:Cerebral Cortex / Q000378:metabolism; D002908:Chronic Disease; D006624:Hippocampus / Q000378:metabolism; D007031:Hypothalamus / Q000378:metabolism; D009687:Nuclear Proteins / Q000378:metabolism*; D010766:Phosphorylation; D011794:Quercetin / Q000494:pharmacology; D051381:Rats; D017208:Rats, Wistar; D013315:Stress, Psychological / Q000378:metabolism*
D009687:Nuclear Proteins; D011794:Quercetin