title: The alpha 1d-adrenoceptor subtype is involved in the noradrenaline-induced contractions of rat aorta.
abstract: The pA2 value of several alpha 1-adrenoceptor antagonists on noradrenaline-induced contractions of rat aorta, and their affinity for the cloned alpha 1a-, alpha 1b- and alpha 1d-adrenoceptor subtypes were evaluated. Selective or moderately selective alpha 1d-, partially selective alpha 1b-, selective alpha 1a- and non subtype-selective alpha 1-adrenoceptors antagonists were included in the study. The potency of these compounds on rat aorta was well correlated with the affinity observed for the alpha 1d-adrenoceptor subtype. A poor correlation was found for the alpha 1b- and alpha 1a-subtypes. These results suggest that the alpha 1d-subtype plays a determining role in rat aorta contractions induced by noradrenaline.
authors.affiliation: Research & Development Department, RECORDATI S.p.A., Milano, Italy.
authors.forename: R
authors.initials: R
authors.lastname: Testa
authors.forename: C
authors.initials: C
authors.lastname: Destefani
authors.forename: L
authors.initials: L
authors.lastname: Guarneri
authors.forename: E
authors.initials: E
authors.lastname: Poggesi
authors.forename: I
authors.initials: I
authors.lastname: Simonazzi
authors.forename: C
authors.initials: C
authors.lastname: Taddei
authors.forename: A
authors.initials: A
authors.lastname: Leonardi
mesh_terms: D000317:Adrenergic alpha-Antagonists / Q000494:pharmacology; D000818:Animals; D001011:Aorta / Q000502:physiology*; D008024:Ligands; D008297:Male; D009119:Muscle Contraction / Q000187:drug effects / Q000502:physiology*; D009131:Muscle, Smooth, Vascular / Q000187:drug effects / Q000502:physiology*; D009638:Norepinephrine / Q000494:pharmacology; D051381:Rats; D017207:Rats, Sprague-Dawley; D018340:Receptors, Adrenergic, alpha-1 / Q000145:classification / Q000502:physiology*
chemical_list: D000317:Adrenergic alpha-Antagonists; D008024:Ligands; D018340:Receptors, Adrenergic, alpha-1; D009638:Norepinephrine