Substituted thiazolidinediones and thio-imidazolidinones: synthesis, structural study and pharmacological activity.
Synthesis and physico-chemical properties of six 3-(4-bromophenacyl)-5-arylidene-thiazolidine-2,4-diones and eight 3-(4-chlorobenzyl)-5-arylidene-4-thio-imidazolidine-2-ones are described. These products were synthesized by an aldolisation-crotonisation reaction from aromatic aldehydes and 3-substituted thiazolidine-2,4-diones or 4-thio-imidazolidine-2-ones. Hypoglycemic and peripheral antinociceptive activities were investigated for these compounds.
Albuquerque
J F
JF
Departamento de Antibiotics, Universidade Federal de Pernambuco, Recife, Brésil.
Albuquerque
A
A
Azevedo
C C
CC
Thomasson
F
F
Galdino
L S
LS
Chantegrel
J
J
Catanho
M T
MT
Pitta
I R
IR
Luu-Duc
C
C
D000478:Alkylation; D000700:Analgesics / Q000138:chemical synthesis* / Q000494:pharmacology; D000818:Animals; D001786:Blood Glucose / Q000378:metabolism; D007004:Hypoglycemic Agents / Q000138:chemical synthesis* / Q000494:pharmacology; D007093:Imidazoles / Q000138:chemical synthesis* / Q000494:pharmacology; D009682:Magnetic Resonance Spectroscopy; D051379:Mice; D010147:Pain Measurement / Q000187:drug effects; D013329:Structure-Activity Relationship; D013844:Thiazoles / Q000138:chemical synthesis* / Q000494:pharmacology
D000700:Analgesics; D001786:Blood Glucose; D007004:Hypoglycemic Agents; D007093:Imidazoles; D013844:Thiazoles