Limited efficacy of experimental anti-epileptic drugs in refractory temporal lobe epilepsy: implications for patient management and study recruitment.
Patients with refractory temporal lobe epilepsy (TLE) are commonly recruited for investigational anti-epileptic drug (XAED) studies. However, the long-term outcome of TLE after exposure to XAEDs is poorly documented. In this pilot study, we report the USC Epilepsy Center's experience of 19 patients with TLE enrolled in three XAED trials. The data reinforce that TLE is a drug-resistant epilepsy, and referral of good surgical candidates for surgery rather than XAED trials is more likely to result in remission.
DeGiorgio
C M
CM
Department of Neurology, USC University Hospital, USA.
Couldwell
W T
WT
Henderson
C
C
Rabinowicz
A L
AL
D000927:Anticonvulsants / Q000009:adverse effects / Q000627:therapeutic use*; D003131:Combined Modality Therapy; D004311:Double-Blind Method; D004351:Drug Resistance; D015507:Drugs, Investigational / Q000009:adverse effects / Q000627:therapeutic use*; D004569:Electroencephalography / Q000187:drug effects; D004833:Epilepsy, Temporal Lobe / Q000188:drug therapy* / Q000601:surgery; D006801:Humans; D010348:Patient Care Team; D011612:Psychosurgery; D016032:Randomized Controlled Trials as Topic; D013702:Temporal Lobe / Q000187:drug effects / Q000601:surgery; D016896:Treatment Outcome
D000927:Anticonvulsants; D015507:Drugs, Investigational