title: Use of the saline infusion electrode catheter for improved energy delivery and increased lesion size in radiofrequency catheter ablation.
abstract: Although radiofrequency catheter ablation has undergone explosive growth as the treatment for a variety of arrhythmias, a limiting factor with the existing catheter delivery system has been the relatively small size of the lesions, which appears to be in part due to coagulum formation around the catheter tip, producing a rise in impedance and limiting energy delivery. In order to test the hypothesis that infusion of saline during radiofrequency current application can increase the lesion size and decrease the incidence of impedance rise, ten dogs were each given two radiofrequency ablation lesions to the left ventricular endocardium. One of these lesions was delivered with a standard 7 French quadripolar catheter with a 2-mm tip, and the second was done with a 7 French luminal electrode catheter (also with a 2-mm tip) for the infusion of normal saline during the delivery of radiofrequency energy. Energy was delivered for 60 seconds at either 10 or 20 watts at two distinct sites in the left ventricle for each animal. Four to 7 days following ablation, the animals were sacrificed for pathological examination. The lesions created with the saline infusion catheter were significantly bigger than those produced with a standard catheter (7.3 x 7.0 x 5.1 vs 5.2 x 4.9 x 3.5 mm, respectively, P < 0.001). At the lower energy level (10 W), none of the animals with the saline infusion catheter experienced an impedance rise versus 3 of 5 of the animals in whom the standard catheter was used.(ABSTRACT TRUNCATED AT 250 WORDS)
authors.affiliation: Department of Medicine, University of Massachusetts Medical Center, Worcester 01655, USA.
authors.forename: R S
authors.initials: RS
authors.lastname: Mittleman
authors.forename: S K
authors.initials: SK
authors.lastname: Huang
authors.forename: W T
authors.initials: WT
authors.lastname: de Guzman
authors.forename: H
authors.initials: H
authors.lastname: Cuénoud
authors.forename: A B
authors.initials: AB
authors.lastname: Wagshal
authors.forename: L A
authors.initials: LA
authors.lastname: Pires
mesh_terms: D000818:Animals; D006328:Cardiac Catheterization / Q000295:instrumentation*; D017115:Catheter Ablation / Q000295:instrumentation*; D004285:Dogs; D004562:Electrocardiography; D004566:Electrodes; D004867:Equipment Design; D005260:Female; D005440:Fluid Therapy / Q000295:instrumentation*; D006352:Heart Ventricles / Q000473:pathology; D008297:Male; D009336:Necrosis; D012965:Sodium Chloride / Q000008:administration & dosage*
chemical_list: D012965:Sodium Chloride