[Modulation of the course of experimental tuberculosis in mice by in vivo administration of monoclonal antibodies to interleukin-2, gamma-interferon and interleukin-4].
The impact of the in vivo administration of monoclonal antibodies against cytokines on the development of a pathological process in mice infected with Mycobacterium tuberculosis H37Rv-infected mice. The susceptibility to fatal experimental tuberculosis, the level of DTH to mycobacterial antigens, the production of specific antimycobacterial IgG and IgM, T-cell proliferative responses to M. tuberculosis H37Rv antigens. Anti-gamma-interferon and anti-IL-2 treatment was found to provide virtually no effects on the course of experimental tuberculosis, the intravenous administration of anti-IL-4-monoclonal antibodies on days 2, 4, and 6 after inoculation with a lethal dose of M. tuberculosis significantly increases the median survival time (MST). This increase in MST is accompanied by a more prominent DTH response and lymphocytic proliferative reaction on the one hand, and by lower concentrations of specific IgG on the other. The therapeutical prospects of anti-IL-4 treatment in tuberculosis are discussed.
Eremeev
V V
VV
Avdienko
V G
VG
Bocharova
I V
IV
Liashenko
S M
SM
Moroz
A M
AM
D000818:Animals; D000907:Antibodies, Bacterial / Q000032:analysis; D000911:Antibodies, Monoclonal / Q000008:administration & dosage*; D000942:Antigens, Bacterial / Q000032:analysis; D005260:Female; D007074:Immunoglobulin G / Q000032:analysis; D007075:Immunoglobulin M / Q000032:analysis; D007371:Interferon-gamma / Q000276:immunology*; D007376:Interleukin-2 / Q000276:immunology*; D015847:Interleukin-4 / Q000276:immunology*; D051379:Mice; D008808:Mice, Inbred CBA; D009169:Mycobacterium tuberculosis / Q000276:immunology; D013997:Time Factors; D014376:Tuberculosis / Q000276:immunology* / Q000401:mortality
D000907:Antibodies, Bacterial; D000911:Antibodies, Monoclonal; D000942:Antigens, Bacterial; D007074:Immunoglobulin G; D007075:Immunoglobulin M; D007376:Interleukin-2; D015847:Interleukin-4; D007371:Interferon-gamma
Modulatsiia techeniia éksperimental'nogo tuberkuleza u mysheĭ vvedeniem in vivo monoklonal'nykh antitel k interleĭkinu-2, gamma-interferonu i interleĭkinu-4.