Hepatic lipocytes: a major target for endothelin-1.
Lipocytes are the predominant target for ET-1 within the normal and fibrotic liver. ET-1-induced contraction of lipocytes becomes prominent in liver injury. In this setting, ET-1 may have an autocrine role in regulating sinusoidal flow, in association with eicosanoids and other endothelium derived factors such as nitric oxide (NO). In more advanced fibrosis, ET-1 may participate in contraction of collagen bands causing distortion of the lobular structure. A direct role of ET-1 in the activation of lipocytes is still hypothetical but could represent additional effects of ET-1 in various stages of liver fibrogenesis via paracrine and/or autocrine routes.
Housset
C N
CN
Liver Core center, University of California, San Francisco, USA.
Rockey
D C
DC
Friedman
S L
SL
Bissell
D M
DM
D017667:Adipocytes / Q000378:metabolism*; D000595:Amino Acid Sequence; D000818:Animals; D002118:Calcium / Q000378:metabolism; D016232:Endothelins / Q000502:physiology*; D006801:Humans; D008099:Liver / Q000737:chemistry / Q000166:cytology*; D008969:Molecular Sequence Data; D012333:RNA, Messenger / Q000032:analysis; D017466:Receptors, Endothelin / Q000032:analysis
D016232:Endothelins; D012333:RNA, Messenger; D017466:Receptors, Endothelin; D002118:Calcium