Columbin isolated from calumbae radix affects the sleeping time of anesthetized mice.
In a screening series of bioactive components in edible and medicinal plants, we found that Calumbae Radix (Colombo root, 1% powdered feed, for 5 d) and its component, columbin (20-40 mg/kg/d, for 5 d, orally), shortened the sleeping time induced by a urethane and alpha-chloralose mixture and prolonged the sleeping time induced by hexobarbital in mice.
Wada
K
K
Faculty of Pharmaceutical Sciences, Health Sciences University of Hokkaido, Japan.
Kurihara
T
T
Yagi
M
M
Kobayashi
R
R
Kaminaga
H
H
Toi
K
K
Haga
M
M
D000758:Anesthesia; D000818:Animals; D004224:Diterpenes / Q000302:isolation & purification / Q000494:pharmacology*; D004305:Dose-Response Relationship, Drug; D004365:Drugs, Chinese Herbal / Q000494:pharmacology*; D006591:Hexobarbital / Q000494:pharmacology; D007783:Lactones / Q000302:isolation & purification / Q000494:pharmacology*; D008297:Male; D051379:Mice; D008815:Mice, Inbred Strains; D010936:Plant Extracts / Q000494:pharmacology; D012890:Sleep / Q000187:drug effects*; D013997:Time Factors; D014520:Urethane / Q000494:pharmacology
D004224:Diterpenes; D004365:Drugs, Chinese Herbal; D007783:Lactones; D010936:Plant Extracts; D014520:Urethane; D006591:Hexobarbital; C062514:columbin