Erythropoietin, erythropoesis and iron status in children after major surgical stress.
The aim of our study was to evaluate bone marrow stimulation and bone marrow response to post-operative anaemia in children after open heart surgery. In 16 children (age 5.7 +/- 0.9 years, weight 20.1 +/- 3.2 kg) serum erythropoietin, haematocrit, reticulocyte count, ferritin, transferrin saturation and C-reactive protein were assessed perioperatively after cardiopulmonary bypass for surgical repair of atrial septal defect. Erythropoietin increased seven fold from 14 +/- 6.2 (7-30) to 80 +/- 49 (20-171) mU/ml (P < 0.05) and the reticulocyte count a 1.7-fold from 11.1 +/- 3.1 (6-19) to 18.4 +/- 5.9 (10-31) / 1000 (P < 0.05). Transferrin saturation was inversely correlated to C-reactive protein.


CONCLUSIONS
These findings suggest adequate bone marrow stimulation but an inadequate bone marrow response during the immediate perioperative period, caused by inhibition of erythropoesis by acute postoperative inflammation in children after open heart surgery.
Aufricht
C
C
Universitäts-Kinderklinik Wien, Austria.
Ties
M
M
Salzer-Muhar
U
U
Wimmer
M
M
Herkner
K
K
Haschke
F
F
D000210:Acute-Phase Reaction / Q000209:etiology / Q000276:immunology; D000704:Analysis of Variance; D000740:Anemia / Q000209:etiology / Q000276:immunology* / Q000628:therapy; D001853:Bone Marrow / Q000276:immunology* / Q000378:metabolism; D002315:Cardiopulmonary Bypass / Q000009:adverse effects*; D002648:Child; D002675:Child, Preschool; D004920:Erythropoiesis / Q000276:immunology; D004921:Erythropoietin / Q000097:blood / Q000627:therapeutic use; D005260:Female; D006344:Heart Septal Defects, Atrial / Q000601:surgery; D006400:Hematocrit; D006439:Hemodynamics; D006801:Humans; D007501:Iron / Q000097:blood; D008297:Male; D011183:Postoperative Complications / Q000097:blood; D012044:Regression Analysis; D017701:Reticulocyte Count
D004921:Erythropoietin; D007501:Iron