[Regulatory effect of ventral tegmental area on sleep-wakefulness in rats].
Experiments were performed on 31 male SD rats. The results were as follows: (1) The time of waking was increased during the second and third hours after microinjection of 3.3 and 6.6 nmol bromocriptine into bilateral VTA (P < 0.01), but the 1.33 nmol group was without significant effect. (2) The time of waking was decreased during the second and third hours after microinjection of 2 and 4 nmol SCH23390 into VTA (P < 0.01 and P < 0.05 respectively), while 3.4 nmol sulpiride group was without effect. (3) One week after administration of kainic acid (0.3 microgram), the rats presented less time of waking in the day (P < 0.05), while sleep-wakefulness cycle at night showed no change. The results suggest that bromocriptine could increase wakefulness by activating VTA DA neurons via D1 receptor and that the DA neurons might exert a tonic effect for maintaining the wakefulness at the daytime.
Zhang
W H
WH
Department of Physiology, Shanghai Second Medical University.
Qian
Z X
ZX
Wang
H H
HH
Cai
K
K
Lin
Y L
YL
D000818:Animals; D001552:Benzazepines / Q000494:pharmacology; D001971:Bromocriptine / Q000494:pharmacology; D007608:Kainic Acid / Q000494:pharmacology; D008297:Male; D008845:Microinjections; D051381:Rats; D017207:Rats, Sprague-Dawley; D012890:Sleep / Q000187:drug effects; D017557:Ventral Tegmental Area / Q000502:physiology*; D014851:Wakefulness / Q000187:drug effects
D001552:Benzazepines; D001971:Bromocriptine; D007608:Kainic Acid