Inhibiting intracellular signalling as a strategy for cancer chemoprevention.
The intracellular signalling pathways that mediate the effects of growth factors and oncogenes on cell growth and transformation offer potential targets for the development of chemopreventive agents that prevent the progression of premalignant cells to invasive cancer. Agents acting on signalling targets would be expected to be cytostatic rather than cytotoxic agents. A number of existing chemopreventive agents exhibit, among their properties, inhibition of intracellular signalling enzymes. It is possible that this activity accounts, at least in part, for their chemopreventive properties.
Powis
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Arizona Cancer Center, University of Arizona Health Sciences Center, Tucson 85724, USA.
Alberts
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D000818:Animals; D016588:Anticarcinogenic Agents / Q000494:pharmacology*; D002118:Calcium / Q000378:metabolism; D006801:Humans; D009369:Neoplasms / Q000517:prevention & control*; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D015398:Signal Transduction / Q000187:drug effects*; D010738:Type C Phospholipases / Q000037:antagonists & inhibitors
D016588:Anticarcinogenic Agents; D011493:Protein Kinase C; D010738:Type C Phospholipases; D002118:Calcium