title: Frequency of hyperprolactinaemia due to large molecular weight prolactin (150-170 kD PRL).
abstract: Of 605 hyperprolactinaemic sera (prolactin > 1000 mU l-1 determined with PRL DELFIA, Wallac) in the routine diagnostic (PRL was measured in 10,737 sera) 26% had an increased amount of PRL with molecular weight (MW) = 150-170 kD (150-170 kD PRL or bigbig PRL). In a series of serum samples from 660 healthy subjects, only one female with hyperprolactinaemia due to increased 150-170 kD PRL was found. The 150-170 kD PRL constituted less than 1% of the total PRL found in 11 patients with prolactinoma (macroprolactinoma, PRL 8800-500,000 mU l-1). When determined with five different commercially available immunometric assays, the PRL values in the sera with large amounts of 150-170 kD were increased in all sera in four of five assays, although they varied widely. The clinical implications of hyperprolactinaemia due to increased 150-170 kD PRL are still uncertain.
authors.affiliation: Hormone Laboratory, Aker University Hospital, Oslo, Norway.
authors.forename: T
authors.initials: T
authors.lastname: Bjøro
authors.forename: L
authors.initials: L
authors.lastname: Mørkrid
authors.forename: R
authors.initials: R
authors.lastname: Wergeland
authors.forename: A
authors.initials: A
authors.lastname: Turter
authors.forename: A
authors.initials: A
authors.lastname: Kvistborg
authors.forename: T
authors.initials: T
authors.lastname: Sand
authors.forename: P
authors.initials: P
authors.lastname: Torjesen
mesh_terms: D000328:Adult; D000368:Aged; D005260:Female; D006801:Humans; D006966:Hyperprolactinemia / Q000097:blood*; D007118:Immunoassay; D008297:Male; D008875:Middle Aged; D008970:Molecular Weight; D011388:Prolactin / Q000097:blood* / Q000737:chemistry; D011863:Radioimmunoassay
chemical_list: D011388:Prolactin