title: Influence of the selection of angiographic projections on the results of coronary angiographic follow-up trials. International Nifedipine Trial on Antiatherosclerotic Therapy Investigators.
abstract: In recent years follow-up trials on coronary artery disease with angiographic end points analyzed quantitatively have gained increasing relevance and popularity. There is no consensus, however, on the method of calculation of progression or regression from multiple angiographic projections. Therefore the influence of the selection of angiographic projections on the outcomes of such trials was investigated with the data of the International Nifedipine Trial on Antiatherosclerotic Therapy. In 348 patients with coronary artery disease, repeated coronary angiograms were compared in multiple identical angiographic projections. Changes in angiographic parameters were averaged over the 1063 stenoses analyzed. Five methods of evaluation of multiple projections in the individual stenoses were applied, resulting in different extents of overall progression, or even regression of coronary artery disease (p < 0.01). It is concluded that in quantitative coronary angiographic follow-up trials changes should be averaged over all angiographic projections available for a stenosis to avoid overestimation of progression or regression.
authors.affiliation: Department of Cardiology, Hannover Medical School, Germany.
authors.forename: S
authors.initials: S
authors.lastname: Jost
authors.forename: J
authors.initials: J
authors.lastname: Deckers
authors.forename: P
authors.initials: P
authors.lastname: Nikutta
authors.forename: J H
authors.initials: JH
authors.lastname: Reiber
authors.forename: W
authors.initials: W
authors.lastname: Rafflenbeul
authors.forename: B
authors.initials: B
authors.lastname: Wiese
authors.forename: H
authors.initials: H
authors.lastname: Hecker
authors.forename: P
authors.initials: P
authors.lastname: Lichtlen
mesh_terms: D000704:Analysis of Variance; D017023:Coronary Angiography / Q000379:methods* / Q000706:statistics & numerical data; D003327:Coronary Disease / Q000000981:diagnostic imaging* / Q000188:drug therapy*; D018450:Disease Progression; D004311:Double-Blind Method; D005500:Follow-Up Studies; D006801:Humans; D007391:International Cooperation; D009543:Nifedipine / Q000627:therapeutic use*; D011446:Prospective Studies; D012008:Recurrence; D012074:Remission Induction
chemical_list: D009543:Nifedipine