Bis(sulfato)-cyclosiphonodictyol A, a new disulfated sesquiterpene-hydroquinone from a deep water collection of the Marine sponge Siphonodictyon coralliphagum.
A new compound, bis(sulfato)-cyclosiphonodictyol A [1], which inhibits the binding of [3H]-LTB4 to intact human neutrophils with an IC50 value of 44 microM, was isolated from the sponge Siphonodictyon coralliphagum. The sponge was collected using the Johnson-Sea-Link manned submersible at a depth of 195 feet in the Bahamas. The compound was isolated via reversed-phase chromatography and its structure determined spectroscopically. To the best of our knowledge, 1 is the first marine-derived compound with two aromatic sulfate ester functionalities, and is also the first in the siphonodictyal series to contain an oxepane functionality.
Killday
K B
KB
Division of Biomedical Marine Research, Harbor Branch Oceanographic Institution, Inc., Ft. Pierce, Florida 34946, USA.
Wright
A E
AE
Jackson
R H
RH
Sills
M A
MA
D000818:Animals; D006801:Humans; D066298:In Vitro Techniques; D016859:Lipoxygenase Inhibitors / Q000302:isolation & purification* / Q000494:pharmacology; D009504:Neutrophils / Q000187:drug effects / Q000201:enzymology / Q000378:metabolism; D011161:Porifera / Q000737:chemistry*; D018102:Receptors, Leukotriene B4 / Q000037:antagonists & inhibitors; D012717:Sesquiterpenes / Q000302:isolation & purification* / Q000494:pharmacology
D016859:Lipoxygenase Inhibitors; D018102:Receptors, Leukotriene B4; D012717:Sesquiterpenes; C095624:bis(sulfato)-cyclosiphonodictyol A