title: Effects of the antacids in didanosine tablets on dapsone pharmacokinetics.
abstract: OBJECTIVE
  To investigate 1) the effects of the magnesium-aluminum antacids in didanosine tablets on dapsone absorption in healthy volunteers and 2) the effects of the antacid formulation of active didanosine tablets on dapsone pharmacokinetics in patients seropositive for human immunodeficiency virus (HIV).
  
  
  METHODS
  Two separate, randomized, two-period, two-treatment, crossover studies with a 21-day washout period between treatments.
  
  
  METHODS
  Clinical investigation unit of a university hospital.
  
  
  METHODS
  Six healthy men and six HIV-positive men.
  
  
  METHODS
  Serial dapsone plasma concentrations were measured when dapsone, 100 mg, was administered alone and with either the third of four doses of didanosine placebo tablets (group 1) or the 27th of 28 doses of active didanosine tablets (group 2). In each study, pharmacokinetic variables were determined using noncompartmental methods and compared by analysis of variance.
  
  
  RESULTS
  When dapsone was administered alone, pharmacokinetic variables did not significantly differ from those with dapsone given in either combination (P > 0.10 for all comparisons).
  
  
  CONCLUSIONS
  Didanosine, antacids, and other excipients in the currently used didanosine chewable tablets did not significantly affect plasma concentrations of dapsone.
authors.affiliation: Clinical Investigation Unit, Ottawa General Hospital, Ontario, Canada.
authors.forename: J
authors.initials: J
authors.lastname: Sahai
authors.forename: G
authors.initials: G
authors.lastname: Garber
authors.forename: K
authors.initials: K
authors.lastname: Gallicano
authors.forename: L
authors.initials: L
authors.lastname: Oliveras
authors.forename: D W
authors.initials: DW
authors.lastname: Cameron
mesh_terms: D000042:Absorption; D000328:Adult; D000535:Aluminum / Q000737:chemistry; D000863:Antacids / Q000737:chemistry / Q000494:pharmacology*; D002626:Chemistry, Pharmaceutical; D018592:Cross-Over Studies; D003622:Dapsone / Q000097:blood / Q000493:pharmacokinetics*; D016049:Didanosine / Q000737:chemistry*; D004347:Drug Interactions; D006679:HIV Seropositivity / Q000097:blood / Q000188:drug therapy; D006801:Humans; D008274:Magnesium / Q000737:chemistry; D008297:Male; D013607:Tablets
chemical_list: D000863:Antacids; D013607:Tablets; D003622:Dapsone; D000535:Aluminum; D008274:Magnesium; D016049:Didanosine