title: [Progress in adrenoceptor research].
abstract: According to pharmacological characteristics and molecular cloning, adrenoceptor is divided into 3 types, and each type contains at least 3 subtypes. The molecular structure of adrenoceptor fits common model of G protein coupled receptors on membrane surface. The structure-function relationship has been basically elucidated by mutation techniques. The ligand binding characteristics are decided by the structures in transmembrane domains, while the G protein coupling sites are in the third intracellular loop. There are extensive crosstalks among the subtypes of adrenoceptor. According to the mechanisms, the crosstalks can be divided into 4 types.
authors.affiliation: Institute of Vascular Medicine, Third Hospital, Beijing Medical University.
authors.forename: Q D
authors.initials: QD
authors.lastname: Han
mesh_terms: D000818:Animals; D019204:GTP-Binding Proteins / Q000502:physiology; D006801:Humans; D011941:Receptors, Adrenergic / Q000737:chemistry / Q000145:classification / Q000502:physiology
chemical_list: D011941:Receptors, Adrenergic; D019204:GTP-Binding Proteins