[Evaluation of copro-allergen specific IgE and eosinophilic cationic protein levels in children with food allergy].
The authors studied copro-allergen specific IgE, eosinophil cationic protein, alpha-1 antitrypsin, IgA and IgG levels in 20 food allergic patients and in 20 controls. It was found that the copro-allergen specific IgE and eosinophil cationic protein levels were significantly higher in food allergic group than in the control group. Carrying out an oral challenge in real food allergic group the copro-allergen specific IgE and eosinophil cationic protein levels were measured before and after the provocation. The results proved that the stopping of allergenic exposure the local immunreactions will finish. Proving this fact it can be said that 24 hours later in the faeces samples the IgE levels decreased and in some case disappeared. The change of eosinophil cationic protein levels during and after the oral challenge proves the important role of eosinophils in late phase reaction. Finally it can be stated that authors introduced a new non invasive methods which is very suitable and reliable to study local immunoreaction in the gastrointestinal tract.
Kósa
L
L
Svábhegyi Gyermekgyógyintézet, Budapest.
Kereki
E
E
Farkas
M
M
D000293:Adolescent; D000485:Allergens / Q000276:immunology*; D001798:Blood Proteins / Q000276:immunology*; D002648:Child; D002675:Child, Preschool; D004064:Digestive System / Q000276:immunology; D047091:Eosinophil Granule Proteins; D005243:Feces / Q000737:chemistry*; D005260:Female; D005512:Food Hypersensitivity / Q000276:immunology*; D006801:Humans; D007073:Immunoglobulin E / Q000276:immunology*; D007159:Immunologic Tests; D007223:Infant; D018836:Inflammation Mediators / Q000276:immunology*; D008297:Male; D012260:Ribonucleases
D000485:Allergens; D001798:Blood Proteins; D047091:Eosinophil Granule Proteins; D018836:Inflammation Mediators; D007073:Immunoglobulin E; D012260:Ribonucleases
Specifikus copro-IgE és eosinophil kationos protein szintek értékelése tápanyagallergiás gyermekekben.