Conservation of the Down syndrome critical region in humans and great apes.
A quarter century ago, a chimpanzee with trisomy 22 was reported to have the clinical manifestation of Down syndrome. The features of Down syndrome in human have been associated with chromosome 21 band q22.3. The recent availability of chromosome and loci specific probes has prompted us to utilize the human cosmid probe (D21S65) for the trisomy 21 region in the chromosomes of the chimpanzee (Pan troglodytes), gorilla (Gorilla gorilla) and orangutan (Pongo pygmeus). Interestingly, the hybridization site for the Down syndrome region was found on the equivalent ape chromosome 22 in all three primates (the human equivalent of chromosome 21). Apparently, these results support the notion that the Down syndrome critical region of human chromosome 21 band q22.3 is conserved in great apes, which has displayed mongolism in a chimpanzee when present in triplicate conditions. Furthermore, other probes can be used as phylogenetic signals to enhance the understanding of human descent.
Luke
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Division of Genetics, Long Island College Hospital, SUNY Health Science Center, Brooklyn 11201, USA.
Gandhi
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Verma
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D000818:Animals; D018420:Ape Diseases / Q000235:genetics*; D005075:Biological Evolution; D002891:Chromosomes, Human, Pair 21; D003360:Cosmids; D004314:Down Syndrome / Q000235:genetics / Q000662:veterinary*; D006071:Gorilla gorilla / Q000235:genetics; D015186:Hominidae / Q000235:genetics*; D006801:Humans; D017404:In Situ Hybridization, Fluorescence; D015335:Molecular Probes; D002679:Pan troglodytes / Q000235:genetics; D011148:Pongo pygmaeus / Q000235:genetics; D013045:Species Specificity; D014314:Trisomy
D015335:Molecular Probes