Creutzfeldt-Jakob disease after liver transplantation.
We report a 57-year-old woman who died from Creutzfeldt-Jakob disease 2 years after a liver transplantation. The liver donor had no history of neurological disease. In one albumin donor, possible Creutzfeldt-Jakob disease developed 3 years later. The patient initially had cerebellar symptoms. Neuropathology included "Kuru-type" plaques and prion protein (PrP) deposits involving the cerebellum predominantly. The patient was homozygote valine at codon 129 of the PrP gene while the liver was homozygote methionine. This observation raises the possibility of transmission of Creutzfeldt-Jakob disease by the graft itself or the associated albumin transfusions and, on a wider extent, by nonneural tissue.
Créange
A
A
Departement de Neurosciences, Centre Hospitalier Universitaire Henri Mondor, Créteil, France.
Gray
F
F
Cesaro
P
P
Adle-Biassette
H
H
Duvoux
C
C
Cherqui
D
D
Bell
J
J
Parchi
P
P
Gambetti
P
P
Degos
J D
JD
D007562:Creutzfeldt-Jakob Syndrome / Q000209:etiology* / Q000473:pathology; D019286:Endopeptidase K; D005260:Female; D006801:Humans; D007049:Iatrogenic Disease; D016031:Liver Transplantation; D008875:Middle Aged; D011183:Postoperative Complications; D011328:Prions / Q000235:genetics; D012697:Serine Endopeptidases
D011328:Prions; D012697:Serine Endopeptidases; D019286:Endopeptidase K