title: A bioactive tetraprenylphenol from Lactarius lignyotus.
abstract: 2-Geranylgeranyl-1,4-dihydroxybenzene [1] and a mixture of fatty acid esters of this phenol were isolated from the fruiting bodies of Lactarius lignyotus. Compound 1 was highly active in the brine shrimp test and showed significant inhibitory activity on DNA, RNA, and protein synthesis in HeLa and HL-60 cell lines.
authors.affiliation: Dipartimento di Chimica Organica, Università di Pavia, Italy.
authors.forename: G
authors.initials: G
authors.lastname: Vidari
authors.forename: P
authors.initials: P
authors.lastname: Vita-Finzi
authors.forename: A M
authors.initials: AM
authors.lastname: Zanocchi
authors.forename: G P
authors.initials: GP
authors.lastname: Noy
mesh_terms: D001487:Basidiomycota / Q000737:chemistry*; D004273:DNA, Neoplasm / Q000096:biosynthesis; D004224:Diterpenes; D004354:Drug Screening Assays, Antitumor; D006367:HeLa Cells; D006801:Humans; D007930:Leucine / Q000378:metabolism; D009363:Neoplasm Proteins / Q000096:biosynthesis; D012334:RNA, Neoplasm / Q000096:biosynthesis; D013729:Terpenes / Q000737:chemistry / Q000302:isolation & purification* / Q000494:pharmacology; D013936:Thymidine / Q000378:metabolism; D014407:Tumor Cells, Cultured; D014529:Uridine / Q000378:metabolism
chemical_list: D004273:DNA, Neoplasm; D004224:Diterpenes; D009363:Neoplasm Proteins; D012334:RNA, Neoplasm; D013729:Terpenes; C026300:geranylgeranylhydroquinone; D007930:Leucine; D013936:Thymidine; D014529:Uridine