title: Myopathy in acquired partial lipodystrophy.
abstract: We describe two women with acquired partial lipodystrophy, one with significant myopathic symptoms and signs. Muscle biopsy of deltoid and quadriceps was performed in each case. The light microscopy findings were of type 1 and type 2 fibre hypertrophy, with an increase in intracytoplasmic fat in both cases. Electron microscopy showed normal fibres, with accumulations of electron-lucent fat droplets between the myofibrils. The cause of the lipodystrophies is uncertain, but myopathy may be a feature, and muscle biopsy studies may help in further defining the syndrome.
authors.affiliation: Academic Unit of Neuroscience, Charing Cross and Westminster Medical School, London, UK.
authors.forename: R W
authors.initials: RW
authors.lastname: Orrell
authors.forename: R C
authors.initials: RC
authors.lastname: Peatfield
authors.forename: C E
authors.initials: CE
authors.lastname: Collins
authors.forename: D F
authors.initials: DF
authors.lastname: Woodrow
authors.forename: J
authors.initials: J
authors.lastname: Moss
authors.forename: M
authors.initials: M
authors.lastname: Press
authors.forename: R J
authors.initials: RJ
authors.lastname: Lane
mesh_terms: D000273:Adipose Tissue; D000293:Adolescent; D000328:Adult; D048909:Diabetes Complications; D005260:Female; D006801:Humans; D006949:Hyperlipidemias / Q000150:complications; D007866:Leg / Q000503:physiopathology*; D008060:Lipodystrophy / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology; D018482:Muscle, Skeletal / Q000503:physiopathology*; D009135:Muscular Diseases / Q000150:complications / Q000175:diagnosis* / Q000503:physiopathology