Microsatellite instability in human prostate cancer.
Microsatellite instability (MSI) was examined at 36 loci, and found in 9 (43%) of the 21 prostatic cancers. A loss of heterozygosity had occurred in five cases (24%). MSI did not correlate with clinical stage, but might play a role in the development of a subset of prostate cancers.
Watanabe
M
M
Department of Pathology, Mie University School of Medicine, Japan.
Imai
H
H
Shiraishi
T
T
Shimazaki
J
J
Kotake
T
T
Yatani
R
R
D000328:Adult; D000368:Aged; D000369:Aged, 80 and over; D000483:Alleles; D004273:DNA, Neoplasm / Q000235:genetics*; D004276:DNA, Satellite / Q000235:genetics*; D004355:Drug Stability; D017353:Gene Deletion; D006579:Heterozygote; D006801:Humans; D008297:Male; D008875:Middle Aged; D011471:Prostatic Neoplasms / Q000235:genetics*
D004273:DNA, Neoplasm; D004276:DNA, Satellite