title: Effect of labetalol on cerebral blood flow, oxygen metabolism and autoregulation in healthy humans.
abstract: We have studied the effects of labetalol on cerebral blood flow (CBF) and cerebral oxygen metabolism (CMRO2) in eight healthy volunteers. CBF was measured by single photon emission computerized tomography before and during infusion of labetalol. CMRO2 was calculated as CBF x cerebral arteriovenous oxygen content difference (CaO2-CvO2). CBF autoregulation was tested during infusion of labetalol by changing arterial pressure and estimating relative changes in global CBF from changes in (CaO2-CvO2). CBF before and during infusion of labetalol was 67 and 65 ml/100 g min-1, respectively (P > 0.05). CMRO2 was 2.9 and 2.8 ml/100 g min-1, respectively (P > 0.05). CBF autoregulation was preserved in all subjects. The lower limit of CBF autoregulation was 88 mm Hg (94% of baseline mean arterial pressure). We conclude that labetalol did not influence global or regional CBF, or CMRO2, and CBF autoregulation was preserved.
authors.affiliation: Department of Anaesthesia, Rigshospitalet, Copenhagen, Denmark.
authors.forename: K S
authors.initials: KS
authors.lastname: Olsen
authors.forename: L B
authors.initials: LB
authors.lastname: Svendsen
authors.forename: F S
authors.initials: FS
authors.lastname: Larsen
authors.forename: O B
authors.initials: OB
authors.lastname: Paulson
mesh_terms: D000328:Adult; D000959:Antihypertensive Agents / Q000494:pharmacology*; D001794:Blood Pressure / Q000187:drug effects; D001921:Brain / Q000378:metabolism*; D002560:Cerebrovascular Circulation / Q000187:drug effects* / Q000502:physiology; D005260:Female; D006706:Homeostasis / Q000187:drug effects*; D006801:Humans; D007741:Labetalol / Q000494:pharmacology*; D008297:Male; D010101:Oxygen Consumption / Q000187:drug effects*; D015899:Tomography, Emission-Computed, Single-Photon
chemical_list: D000959:Antihypertensive Agents; D007741:Labetalol