Leucocytosis as a marker of organ damage induced by chronic strenuous physical exercise.
The effects of strenuous physical exercise on the serial changes in the haematological, biochemical and hormonal markers were investigated. A group of 14 soldiers, aged 24-36 years, took part in a military training course for about 13 weeks. After severe exercise stress, an increase (90%) in the number of peripheral blood leucocytes was observed. The degree of leucocytosis showed a close correlation with the values of some serum parameters, such as concentrations of aspartate aminotransferase (AST; r = 0.747), lactate dehydrogenase (LD; r = 0.748), blood urea nitrogen (r = 0.756), creatine kinase (CK; r = 0.637), manganese-superoxide dismutase (Mn-SOD; r = 0.508), alanine aminotransferase (ALT; r = 0.542) and uric acid (r = 0.538), and concentrations of urinary parameters, such as vanilmandelic acid (r = 0.429) and free cortisol (r = 0.437). The subjects showing prominent leucocytosis over 9500 cells.microliters-1 exhibited a lower concentration of serum cholinesterase than those who showed milder leucocytosis. The serum Mn-SOD concentration was closely correlated with the serial changes in serum concentrations of AST, ALT, LD and CK, indicating exercise-induced muscle and liver damage. The change in peripheral leucocyte number was assumed to be diagnostically informative and may be a prognostic marker, reflecting organ damage and restoration after strenuous physical exercise.
Kayashima
S
S
Third Department of Internal Medicine, National Defense Medical College, Saitama, Japan.
Ohno
H
H
Fujioka
T
T
Taniguchi
N
N
Nagata
N
N
D000328:Adult; D015415:Biomarkers; D001823:Body Composition / Q000502:physiology; D001835:Body Weight / Q000502:physiology; D016207:Cytokines / Q000097:blood; D015444:Exercise / Q000502:physiology*; D006728:Hormones / Q000652:urine; D006801:Humans; D007958:Leukocyte Count; D007964:Leukocytosis / Q000097:blood / Q000209:etiology*; D008099:Liver / Q000293:injuries; D008297:Male; D018482:Muscle, Skeletal / Q000293:injuries; D011379:Prognosis; D013482:Superoxide Dismutase / Q000097:blood
D015415:Biomarkers; D016207:Cytokines; D006728:Hormones; D013482:Superoxide Dismutase