A new mutant rat with hyperbilirubinuria (hyb).
We have discovered mutant rats with hyperbilirubinuria at the laboratories of Eisai Co., Ltd., Gifu, Japan, and established a new inbred mutant strain, which was designated Eisai Hyperbilirubinuria Rat (EHBR/Eis). They show jaundice immediately after birth, and direct or conjugated hyperbilirubinemia throughout their life. The phenotypes are controlled by a single autosomal recessive gene, hyb with full penetrance. Affected homozygous males seem to have full reproductive capacity. On the other hand, the litter size of hyb/hyb females is significantly reduced at second parturition compared with that at first one. In order to maintain the strain efficiently and to produce both affected (hyb/hyb) and normal control (hyb/+) offspring at the same time, we have mainly been mating hyb/hyb males with hyb/+ females in establishing the inbred strain. We also report here the allele distribution of the EHBR/Eis strain.
Yamazaki
K
K
Tsukuba Research Laboratories, Eisai Co., Ltd., Ibaraki, Japan.
Mikami
T
T
Hosokawa
S
S
Tagaya
O
O
Nozaki
Y
Y
Kawaguchi
A
A
Funami
H
H
Katoh
H
H
Yamamoto
N
N
Wakabayashi
T
T
D000818:Animals; D001663:Bilirubin / Q000652:urine*; D005260:Female; D006933:Hyperbilirubinemia, Hereditary / Q000652:urine*; D008098:Litter Size; D008297:Male; D010641:Phenotype; D051381:Rats; D011922:Rats, Mutant Strains / Q000652:urine*
D001663:Bilirubin