[Preparation and characterization of amphiphilic membranes with lyotropic mesophases for simulation of skin permeation resistance].
New amphiphilic polymer networks based on methacrylates with amphiphilic side-chains were prepared by cross-linking. Undecanol was the lipophilic part and tetraoxyethylen the hydrophilic part of the side-chain. The cross-linking was performed by a similarly derived amphiphilic dimethacrylate connecting structure. To characterize the relevant membrane features, like solvatation, degree of cross-linking, phase behavior and glass transition temperature, predominantly the swelling properties in water as well as in certain organic solvents, but also polarisation microscopic examinations were used. It was intented to assess the dependence of these parameters from the degree of cross-linking. For this reason the different systems were ranked accordingly to their cross-linking. Their swelling degree was determined in the indifferent dioxane as swelling medium. In the binary phase diagram with water the systems show a prominent laminary phase in the area with water contents of about 20-80% up to a maximum temperature of 35 degrees C. The phase behavior was also confirmed by thermal analysis, and the results of swelling measurements in water. Despite the relatively small hydrophilic part of the molecule, the swelling of the tested new cross-linked systems is more intensive in water than in nonpolar organic solvents. The swelling characteristics and phase behavior show a certain comparability to the human skin.
Hermes
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Lehrstuhl für Pharmazeutische Technologie, Albert-Ludwigs-Universität, Freiburg.
Bauer
K H
KH
D003432:Cross-Linking Reagents; D007700:Kinetics; D008567:Membranes, Artificial; D008954:Models, Biological; D011109:Polymethacrylic Acids; D012869:Skin Absorption / Q000502:physiology*; D013696:Temperature
D003432:Cross-Linking Reagents; D008567:Membranes, Artificial; D011109:Polymethacrylic Acids; C030613:polymethacrylic acid
Herstellung und Charakterisierung amphiphiler Membranen mit lyotropen Mesophasen für die Simulation des Hautpermeationswiderstandes.