Tumor rejection after direct costimulation of CD8+ T cells by B7-transfected melanoma cells.
A variety of tumors are potentially immunogenic but do not stimulate an effective anti-tumor immune response in vivo. Tumors may be capable of delivering antigen-specific signals to T cells, but may not deliver the costimulatory signals necessary for full activation of T cells. Expression of the costimulatory ligand B7 on melanoma cells was found to induce the rejection of a murine melanoma in vivo. This rejection was mediated by CD8+ T cells; CD4+ T cells were not required. These results suggest that B7 expression renders tumor cells capable of effective antigen presentation, leading to their eradication in vivo.
Townsend
S E
SE
Department of Molecular and Cell Biology, University of California, Berkeley 94720.
Allison
J P
JP
D000818:Animals; D000938:Antigen-Presenting Cells / Q000276:immunology; D000954:Antigens, Surface / Q000235:genetics / Q000276:immunology*; D018122:B7-1 Antigen; D015496:CD4-Positive T-Lymphocytes / Q000276:immunology; D003429:Cross Reactions; D005260:Female; D005786:Gene Expression Regulation; D005822:Genetic Vectors; D008024:Ligands; D008213:Lymphocyte Activation; D008545:Melanoma / Q000276:immunology*; D051379:Mice; D008807:Mice, Inbred BALB C; D008809:Mice, Inbred C3H; D008819:Mice, Nude; D050378:T-Lymphocytes, Regulatory / Q000276:immunology*; D014162:Transfection; D014407:Tumor Cells, Cultured
D000954:Antigens, Surface; D018122:B7-1 Antigen; D008024:Ligands