Targeting proteins to membranes using signal sequences for lipid modification.
Covalent attachment of lipids appears to be an important mechanism by which many proteins interact with membranes. As we learn more about how lipids and adjacent amino acids participate in addressing proteins to specific membranes within the cell, it should be possible to design more elegant and precise membrane targeting systems that can be used to guide proteins to functionally relevant destinations.
Solski
P A
PA
Department of Pharmacology, University of North Carolina at Chapel Hill 27599, USA.
Quilliam
L A
LA
Coats
S G
SG
Der
C J
CJ
Buss
J E
JE
D000595:Amino Acid Sequence; D000818:Animals; D001483:Base Sequence; D017931:DNA Primers; D019204:GTP-Binding Proteins / Q000378:metabolism; D005822:Genetic Vectors; D008322:Mammals; D008969:Molecular Sequence Data; D016254:Mutagenesis, Insertional; D019814:Myristic Acid; D009227:Myristic Acids / Q000378:metabolism*; D009838:Oligodeoxyribonucleotides; D019308:Palmitic Acid; D010169:Palmitic Acids / Q000378:metabolism*; D016133:Polymerase Chain Reaction / Q000379:methods; D017368:Protein Prenylation; D011499:Protein Processing, Post-Translational; D021382:Protein Sorting Signals / Q000378:metabolism; D011505:Protein-Tyrosine Kinases / Q000378:metabolism; D011506:Proteins / Q000378:metabolism*; D015183:Restriction Mapping; D018631:ras Proteins / Q000096:biosynthesis
D017931:DNA Primers; D009227:Myristic Acids; D009838:Oligodeoxyribonucleotides; D010169:Palmitic Acids; D021382:Protein Sorting Signals; D011506:Proteins; D019814:Myristic Acid; D019308:Palmitic Acid; D011505:Protein-Tyrosine Kinases; D019204:GTP-Binding Proteins; D018631:ras Proteins