title: Isolation and structure of two novel muscarinic receptor antagonists.
abstract: The structures of two novel muscarinic receptor antagonists, 1 and 2, were determined by their spectral data and high-resolution mass measurements of their degradation products. Both are aliphatic long-chain compounds and contain amide and keto functionalities. The major microbial metabolite [1] contains three terminal guanidino groups and the minor compound [2] has two terminal guanidino groups.
authors.affiliation: Schering-Plough Research Institute, Kenilworth, New Jersey 07033-0539, USA.
authors.forename: V R
authors.initials: VR
authors.lastname: Hedge
authors.forename: J E
authors.initials: JE
authors.lastname: Silver
authors.forename: M G
authors.initials: MG
authors.lastname: Patel
authors.forename: V P
authors.initials: VP
authors.lastname: Gullo
authors.forename: P R
authors.initials: PR
authors.lastname: Das
authors.forename: M S
authors.initials: MS
authors.lastname: Puar
mesh_terms: D000191:Actinomycetaceae / Q000737:chemistry*; D002851:Chromatography, High Pressure Liquid; D006868:Hydrolysis; D009682:Magnetic Resonance Spectroscopy; D018727:Muscarinic Antagonists / Q000302:isolation & purification / Q000494:pharmacology*; D011813:Quinuclidinyl Benzilate; D011976:Receptors, Muscarinic / Q000187:drug effects*; D012988:Soil Microbiology; D013055:Spectrophotometry, Infrared; D013056:Spectrophotometry, Ultraviolet
chemical_list: D018727:Muscarinic Antagonists; D011976:Receptors, Muscarinic; D011813:Quinuclidinyl Benzilate