Oleylamine and stearylamine increase phosphatidylserine synthesis in T cells by synergy with calcium ions.
Oleylamine and stearylamine, two cationic amphiphilic drugs, strongly increase phosphatidylserine synthesis in human T cells. The two compounds had little effect on either phosphatidylcholine or phosphatidylethanolamine synthesis. A decrease in the formation of phosphatidylethanolamine through decarboxylation of phosphatidylserine was observed, but this effect is only marginally involved in increased phosphatidylserine synthesis. The high incorporation of [3H]-serine into phosphatidylserine is a protein kinase C independent process and is due to a synergy of either oleyamine or stearylamine with calcium ions.
Aussel
C
C
INSERM U343, Hôpital de l'Archet, Nice, France.
Pelassy
C
C
Bernard
A
A
D000588:Amines / Q000494:pharmacology*; D002118:Calcium / Q000494:pharmacology*; D000252:Calcium-Transporting ATPases / Q000037:antagonists & inhibitors; D004357:Drug Synergism; D004533:Egtazic Acid / Q000494:pharmacology; D004791:Enzyme Inhibitors / Q000494:pharmacology; D004983:Ethanolamines / Q000378:metabolism; D005233:Fatty Alcohols / Q000494:pharmacology; D006801:Humans; D007700:Kinetics; D010718:Phosphatidylserines / Q000096:biosynthesis* / Q000378:metabolism; D010743:Phospholipids / Q000096:biosynthesis / Q000378:metabolism; D011493:Protein Kinase C / Q000037:antagonists & inhibitors; D012694:Serine / Q000378:metabolism; D013601:T-Lymphocytes / Q000378:metabolism*; D013729:Terpenes / Q000494:pharmacology; D019284:Thapsigargin; D013997:Time Factors; D014407:Tumor Cells, Cultured
D000588:Amines; D004791:Enzyme Inhibitors; D004983:Ethanolamines; D005233:Fatty Alcohols; D010718:Phosphatidylserines; D010743:Phospholipids; D013729:Terpenes; D012694:Serine; D004533:Egtazic Acid; D019284:Thapsigargin; D011493:Protein Kinase C; D000252:Calcium-Transporting ATPases; C009317:stearylamine; D002118:Calcium; C008703:oleylamine