title: Experimental infection of Danish Landrace/Yorkshire crossbred pigs with Schistosoma japonicum from the People's Republic of China.
abstract: This study was undertaken to assess the suitability of Danish Landrace/Yorkshire (L/Y) crossbred pigs as experimental hosts of a Chinese mainland strain of Schistosoma japonicum. Pigs were exposed to 200, 500 or 1000 cercariae and parasite burdens were determined by perfusion after either 8 or 11 weeks. All pigs became infected with onset of faecal egg excretion 6 to 7 weeks following exposure to cercariae. The pattern of faecal egg excretion differed markedly among the individual animals. Gross hepatic pathological lesions of varying degrees were noted in all of the pigs. Schistosome worm recoveries ranged from 1.5-23.4% of the cercarial exposure dose. Most schistosome eggs recovered from the tissues, expressed as eggs/g tissue, were found in the rectum (91%), caecum (3.1%) and liver (5.1%). The results show that Danish L/Y pigs may serve as appropriate experimental final hosts of the Chinese mainland strain of S. japonicum.
authors.affiliation: Danish Centre for Experimental Parasitology, Royal Veterinary and Agricultural University, Frederiksberg.
authors.forename: A L
authors.initials: AL
authors.lastname: Willingham
authors.forename: M V
authors.initials: MV
authors.lastname: Johansen
authors.forename: B J
authors.initials: BJ
authors.lastname: Vennervald
authors.forename: N O
authors.initials: NO
authors.lastname: Christensen
authors.forename: P
authors.initials: P
authors.lastname: Nansen
mesh_terms: D000818:Animals; D002681:China; D003718:Denmark; D005243:Feces / Q000469:parasitology; D005260:Female; D008099:Liver / Q000469:parasitology / Q000473:pathology; D008297:Male; D010270:Parasite Egg Count / Q000662:veterinary; D012549:Schistosoma japonicum / Q000302:isolation & purification / Q000502:physiology*; D012554:Schistosomiasis japonica / Q000469:parasitology / Q000662:veterinary*; D013047:Specific Pathogen-Free Organisms; D013552:Swine; D013553:Swine Diseases / Q000469:parasitology*