Histamine release from rat mast cells induced by the inhibition of adenosinetriphosphatase for Na and K channels.
6-Tridecylresorcylic acid (TRA) caused histamine release from rat peritoneal mast cells in a dose-dependent manner. The release of histamine by TRA was also time dependent. On the other hand, high K+ (150 mM) strongly inhibited TRA-induced histamine release from rat mast cells. These results suggest that histamine release from mast cells might be associated with K+ channel activity.
Takei
M
M
Faculty of Pharmaceutical Science, Tokushima Bunri University, Japan.
Endo
K
K
Umeyama
A
A
Shoji
N
N
D000205:Actomyosin / Q000378:metabolism; D000251:Adenosine Triphosphatases / Q000037:antagonists & inhibitors*; D000818:Animals; D006636:Histamine Release / Q000187:drug effects*; D062385:Hydroxybenzoates / Q000494:pharmacology; D066298:In Vitro Techniques; D007700:Kinetics; D008297:Male; D008407:Mast Cells / Q000187:drug effects / Q000378:metabolism*; D009132:Muscles / Q000201:enzymology / Q000378:metabolism; D009218:Myosins / Q000378:metabolism; D015221:Potassium Channels / Q000187:drug effects*; D051381:Rats; D017208:Rats, Wistar; D015222:Sodium Channels / Q000187:drug effects*; D000254:Sodium-Potassium-Exchanging ATPase / Q000037:antagonists & inhibitors
D062385:Hydroxybenzoates; D015221:Potassium Channels; D015222:Sodium Channels; C042674:6-tridecylresorcylic acid; D000205:Actomyosin; D000251:Adenosine Triphosphatases; D009218:Myosins; D000254:Sodium-Potassium-Exchanging ATPase