[The expressions of proliferating cell nuclear antigen (PCNA) in primary gallbladder carcinoma and its significance].
Anti-PCNA monoclonal antibody and ABC staining were used to study the expressions of proliferating cell nuclear antigen/cyclin in patients with primary gallbladder carcinoma (31 cases), adenoma and tumor-like lesions of gallbladder (10 cases), and chronic cholecystitis (7 cases). The PCNA indices were 373.48 +/- 219.83, 94.9 +/- 93, and 56 +/- 28.63, respectively. This index was significantly higher in malignant lesions than in benign diseases (P < 0.01). There was a tendency that the higher the PCNA index, the lower differential degree of the gallbladder carcinoma (P < 0.01). But there were no significant correlations between the PCNA indices and the pathohistological types, the nevin classifications and the TNM classifications of the gallbladder carcinoma (P > 0.05).
Qing
D
D
Affiliated Hospital of Guiyang Medical College.
Xia
L
L
Zhang
X
X
D000230:Adenocarcinoma / Q000276:immunology* / Q000473:pathology; D000231:Adenocarcinoma, Papillary / Q000276:immunology / Q000473:pathology; D000236:Adenoma / Q000276:immunology / Q000473:pathology; D002764:Cholecystitis / Q000276:immunology; D005706:Gallbladder Neoplasms / Q000276:immunology* / Q000473:pathology; D006801:Humans; D007150:Immunohistochemistry; D018809:Proliferating Cell Nuclear Antigen / Q000032:analysis*
D018809:Proliferating Cell Nuclear Antigen