title: [Exacerbation of Hailey-Hailey disease by infection with herpes simplex virus. Detection with polymerase chain reaction].
abstract: A 49-year-old man suffered from Hailey-Hailey disease for several years. The patient presented with an acute exacerbation of the disease, which did not respond to oral treatment with high doses of glucocorticosteroids. A skin biopsy was taken and the histological examination indicated a viral infection. Herpes simplex virus was confirmed by electron microscopy (negative staining) and polymerase chain reaction (PCR). The PCR presents a sensitive and effective molecular-biological method for the diagnosis of viral infections.
authors.affiliation: Dermatologische Klinik und Poliklinik, Ludwig-Maximilians-Universität, München.
authors.forename: H
authors.initials: H
authors.lastname: Schirren
authors.forename: C G
authors.initials: CG
authors.lastname: Schirren
authors.forename: E M
authors.initials: EM
authors.lastname: Schlüpen
authors.forename: M
authors.initials: M
authors.lastname: Volkenandt
authors.forename: P
authors.initials: P
authors.lastname: Kind
mesh_terms: D001706:Biopsy; D004279:DNA, Viral / Q000302:isolation & purification; D006558:Herpes Genitalis / Q000175:diagnosis* / Q000473:pathology; D006561:Herpes Simplex / Q000175:diagnosis* / Q000473:pathology; D006801:Humans; D008297:Male; D008854:Microscopy, Electron; D008875:Middle Aged; D016506:Pemphigus, Benign Familial / Q000175:diagnosis* / Q000473:pathology; D010409:Penile Diseases / Q000175:diagnosis* / Q000473:pathology; D016133:Polymerase Chain Reaction; D012867:Skin / Q000473:pathology
chemical_list: D004279:DNA, Viral
vernacular_title: Exazerbation eines Morbus Hailey-Hailey durch Infektion mit Herpes-simplex-Virus. Nachweis mittels Polymerasekettenreaktion.