Evidence of different complementation groups amongst human genetic disorders characterized by radiosensitivity.
The genetic diversity of a clinically heterogeneous group of ionizing radiation-sensitive human mutants has been examined. In this group, the relationship between ataxia telangiectasia (A-T), Alzheimer's disease (AD) and Down's syndrome (DS) was studied, on the basis of their cellular radiosensitivity. Cell-fusion analysis was used to determine the presence of different complementation groups. In a series of 4A-T, 5AD and 4DS cell lines, 8 complementation groups were documented. These findings suggest that this group of primary neuronal degenerative disorders might have some overlap in their genetic defects.
Chen
P
P
Queensland Cancer Fund Research Unit, Bancroft Centre, Brisbane, Australia.
Kidson
C
C
Lavin
M
M
D000544:Alzheimer Disease / Q000235:genetics*; D001260:Ataxia Telangiectasia / Q000235:genetics*; D002459:Cell Fusion; D002460:Cell Line; D004314:Down Syndrome / Q000235:genetics*; D005816:Genetic Complementation Test; D006801:Humans; D010641:Phenotype; D011836:Radiation Tolerance