HLA antigens in Omani patients with vitiligo.
Fifty native Omanis with vitiligo were studied to compare the incidence of HLA ABC and DR antigens with a control population. HLA Bw6 was found in 82% of patients compared with 49% controls (Pc = 0.0009 RR = 4.56) and HLA DR7 occurred in 40% of patients and 9% in controls (Pc = 0.00075 RR = 6.17). HLA DR7 was significantly increased in those patients with acrofacial, compared to focal disease (57% vs. 24% P = 0.038). Sixty-six per cent of the patients in this study had parents who were consanguineous and a positive family history was only found in this group with an incidence of 32%. HLA Bw4 segregated 100% with patients with a positive family history compared with 48% in consanguineous patients without a positive family history (Pc = 0.011 RR = 23). Vitiligo appears to be associated with different HLA antigens in different ethnic groups.
Venkataram
M N
MN
Department of Dermatology, Al Nadha Hospital, Muscat, Sultanate of Oman.
White
A G
AG
Leeny
W A
WA
al Suwaid
A R
AR
Daar
A S
AS
D005260:Female; D006680:HLA Antigens / Q000097:blood*; D006650:Histocompatibility Testing; D006801:Humans; D008297:Male; D009850:Oman; D014820:Vitiligo / Q000208:ethnology / Q000276:immunology*
D006680:HLA Antigens