title: [Characteristics of the pool of blood free amino acids of rats during extended hypokinesis].
abstract: 23 free amino acids (AA) were analyzed in blood plasma of rats during 70- and 140-day hypokinesia (HK). The total content of free AA after 70-day HK was found to level down by one third as a result of reduction of the majority of AA excluding glutamate, glutamine, and cystine, the concentrations of which exceeded controls by 21.8%, 4.6%, and 6.3%, respectively. The period of HK extended up to 140 days, the sum of free AA remained lowered; however, glutamate and cystine levels were higher than in control by 10.3% and 183.2%, respectively. The causes for changes of absolute (mM/l) and relative (% in the pool) concentrations of individual AA and their metabolic groups with account for specificity of neuroendocrine regulation and energy metabolism in the skeletal muscles, myocardium, liver, kidneys in dehydrated organism are discussed.
authors.forename: A I
authors.initials: AI
authors.lastname: Gritsuk
mesh_terms: D000596:Amino Acids / Q000097:blood* / Q000378:metabolism; D000818:Animals; D003553:Cystine / Q000097:blood; D003681:Dehydration / Q000378:metabolism; D018698:Glutamic Acid / Q000097:blood; D005973:Glutamine / Q000097:blood; D018476:Hypokinesia / Q000097:blood* / Q000378:metabolism; D007668:Kidney / Q000378:metabolism; D008099:Liver / Q000378:metabolism; D008297:Male; D009132:Muscles / Q000378:metabolism; D009206:Myocardium / Q000378:metabolism; D009490:Neurosecretory Systems / Q000378:metabolism; D051381:Rats; D013997:Time Factors
chemical_list: D000596:Amino Acids; D005973:Glutamine; D018698:Glutamic Acid; D003553:Cystine
vernacular_title: Kharakteristika pula svobodnykh aminokislot plazmy krovi krys pri dlitel'noĭ gipokinezii.